LOCUS 006_Delta6_1_auf_Barbe 3897434 bp DNA circular CON 12-JAN-2021 DEFINITION Bacillus subtilis subsp. subtilis str. 168 complete genome. ACCESSION NC_000964 DBLINK BioProject: PRJNA76 BioSample: SAMEA3138188 KEYWORDS RefSeq; complete genome. SOURCE Bacillus subtilis subsp. subtilis str. 168 ORGANISM Bacillus subtilis subsp. subtilis str. 168 Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. REFERENCE 1 AUTHORS Borriss,R., Danchin,A., Harwood,C.R., Medigue,C., Rocha,E.P.C., Sekowska,A. and Vallenet,D. TITLE Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement JOURNAL Microb Biotechnol 11 (1), 3-17 (2018) PUBMED 29280348 REFERENCE 2 (bases 1 to 4215606) AUTHORS Belda,E., Sekowska,A., Le, Fevre,F., Morgat,A., Mornico,D., Ouzounis,C., Vallenet,D., Medigue,C. and Danchin,A. TITLE An updated metabolic view of the Bacillus subtilis 168 genome JOURNAL Microbiology (Reading, Engl.) 159 (Pt 4), 757-770 (2013) PUBMED 23429746 REFERENCE 3 (bases 1 to 4215606) AUTHORS Barbe,V., Cruveiller,S., Kunst,F., Lenoble,P., Meurice,G., Sekowska,A., Vallenet,D., Wang,T., Moszer,I., Medigue,C. and Danchin,A. TITLE From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later JOURNAL Microbiology (Reading, Engl.) 155 (Pt 6), 1758-1775 (2009) PUBMED 19383706 REFERENCE 4 (bases 1 to 4215606) AUTHORS Kunst,F., Ogasawara,N., Moszer,I., Albertini,A.M., Alloni,G., Azevedo,V., Bertero,M.G., Bessieres,P., Bolotin,A., Borchert,S., Borriss,R., Boursier,L., Brans,A., Braun,M., Brignell,S.C., Bron,S., Brouillet,S., Bruschi,C.V., Caldwell,B., Capuano,V., Carter,N.M., Choi,S.K., Cordani,J.J., Connerton,I.F., Cummings,N.J., Daniel,R.A., Denziot,F., Devine,K.M., Dusterhoft,A., Ehrlich,S.D., Emmerson,P.T., Entian,K.D., Errington,J., Fabret,C., Ferrari,E., Foulger,D., Fritz,C., Fujita,M., Fujita,Y., Fuma,S., Galizzi,A., Galleron,N., Ghim,S.Y., Glaser,P., Goffeau,A., Golightly,E.J., Grandi,G., Guiseppi,G., Guy,B.J., Haga,K., Haiech,J., Harwood,C.R., Henaut,A., Hilbert,H., Holsappel,S., Hosono,S., Hullo,M.F., Itaya,M., Jones,L., Joris,B., Karamata,D., Kasahara,Y., Klaerr-Blanchard,M., Klein,C., Kobayashi,Y., Koetter,P., Koningstein,G., Krogh,S., Kumano,M., Kurita,K., Lapidus,A., Lardinois,S., Lauber,J., Lazarevic,V., Lee,S.M., Levine,A., Liu,H., Masuda,S., Mauel,C., Medigue,C., Medina,N., Mellado,R.P., Mizuno,M., Moestl,D., Nakai,S., Noback,M., Noone,D., O'Reilly,M., Ogawa,K., Ogiwara,A., Oudega,B., Park,S.H., Parro,V., Pohl,T.M., Portelle,D., Porwollik,S., Prescott,A.M., Presecan,E., Pujic,P., Purnelle,B., Rapoport,G., Rey,M., Reynolds,S., Rieger,M., Rivolta,C., Rocha,E., Roche,B., Rose,M., Sadaie,Y., Sato,T., Scanlan,E., Schleich,S., Schroeter,R., Scoffone,F., Sekiguchi,J., Sekowska,A., Seror,S.J., Serror,P., Shin,B.S., Soldo,B., Sorokin,A., Tacconi,E., Takagi,T., Takahashi,H., Takemaru,K., Takeuchi,M., Tamakoshi,A., Tanaka,T., Terpstra,P., Togoni,A., Tosato,V., Uchiyama,S., Vandebol,M., Vannier,F., Vassarotti,A., Viari,A., Wambutt,R., Wedler,H., Weitzenegger,T., Winters,P., Wipat,A., Yamamoto,H., Yamane,K., Yasumoto,K., Yata,K., Yoshida,K., Yoshikawa,H.F., Zumstein,E., Yoshikawa,H. and Danchin,A. TITLE The complete genome sequence of the gram-positive bacterium Bacillus subtilis JOURNAL Nature 390 (6657), 249-256 (1997) PUBMED 9384377 REFERENCE 5 (bases 1 to 4215606) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (17-SEP-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 6 (bases 1 to 4215606) AUTHORS Genoscope and -,C.E.A. CONSRTM AMAbiotics and Genoscope TITLE Direct Submission JOURNAL Submitted (24-JAN-2013) A. Danchin, AMAbiotics, Bldg G1, 2, rue Gaston Cremieux, 91000 EVRY antoine.danchin@normalesup.org Bldg G1 Genoscope / CEA (Commissariat a l'energie atomique et aux energies alternatives): BP 191 91006 EVRY cedex - FRANCE (E-mail: seqref@genoscope.cns.fr - Web: www.genoscope.cns.fr) REFERENCE 7 (bases 1 to 4215606) AUTHORS Genoscope and -,C.E.A. CONSRTM Institut Pasteur and Genoscope TITLE Direct Submission JOURNAL Submitted (29-JAN-2009) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr) REFERENCE 8 (bases 1 to 4215606) AUTHORS Kunst,F., Ogasawara,N., Yoshikawa,H. and Danchin,A. TITLE Direct Submission JOURNAL Submitted (18-NOV-1997) I. Moszer, A. Danchin, Genetique des Genomes Bacteriens, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, FRANCE. E-mail: moszer@pasteur.fr, antoine.danchin@normalesup.org Phone: +33 (0)1 45 68 84 41, Fax: +33 (0)1 45 68 89 48 COMMENT ##gff-version-START## gff-version :: 3 ##gff-version-END## FEATURES Location/Qualifiers S_feature 1..148 /Source="Nicolas_S_feature" /locus_tag="new_1_148" /HighExp="T0.30H, C30, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, S2, T-1.10H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1" S_feature complement(24..297) /Source="Nicolas_S_feature" /locus_tag="new_24_297_c" /HighExp="S8, C30, Etha, S3, S7, S4, Cold, BT, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.178448" /TUshortSig="SigK, SigEF" /TUshortPSig="0.621, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S2" promotor_-35 120..124 /Source="Nicolas_upshift_promotors" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" /label="promotor_-35" promotor_-10 140..159 /Source="Nicolas_upshift_promotors" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" /label="promotor_-10" S_feature 150..409 /Source="Nicolas_S_feature" /locus_tag="new_150_409" /HighExp="Heat, G180, LPhT, G150, dia15, Oxctl, S1, G135, LBGstat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S3" upshifts 150 /Source="Nicolas_upshifts" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" promotor_-10 complement(285..304) /Source="Nicolas_upshift_promotors" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(297) /Source="Nicolas_upshifts" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" S_feature complement(299..1067) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" promotor_-35 complement(318..326) /Source="Nicolas_upshift_promotors" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" /label="promotor_-35" CDS 410..1750 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" gene 410..1750 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" promotor_-10 complement(1040..1058) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1066) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" promotor_-35 complement(1074..1079) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1751..1938 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1939..3075 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" gene 1939..3075 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" downshifts 3059 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" promotor_-35 3140..3144 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3161..3180 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3169 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" CDS 3206..3421 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" gene 3206..3421 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" CDS 3437..4549 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" gene 3437..4549 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" misc_feature 3635..3654 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3653 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" CDS 4567..4812 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" gene 4567..4812 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" CDS 4867..6783 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" gene 4867..6783 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" promotor_-10 complement(6412..6430) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6414) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(6446..6451) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6784..6993 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6994..9459 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" gene 6994..9459 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" promotor_-35 9373..9376 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9374 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 9393..9410 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9440 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" promotor_-35 9504..9510 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9524..9543 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9529..9614 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9529 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" promotor_-35 9600..9607 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9616 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 9622..9641 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9810..11364 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 9810..11364 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" tRNA 11464..11540 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11464..11540 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" tRNA 11552..11627 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11552..11627 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" rRNA 11709..14636 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11709..14636 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" rRNA 14692..14810 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 14692..14810 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" S_feature 14811..15868 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14847..15794) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" gene complement(14847..15794) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" promotor_-35 15847..15854 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15869..15888 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15870 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" upshifts complement(15875) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" promotor_-10 complement(15884..15895) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15909..15915) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15915..17381 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" gene 15915..17381 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" downshifts complement(15919) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(15945..16045) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15985) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(17238..17833) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 17369 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" promotor_-35 17427..17431 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17447..17466 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17453..17533 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17453 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" CDS 17534..18865 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" gene 17534..18865 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" promotor_-10 complement(17822..17840) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17833) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" promotor_-35 complement(17855..17861) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18747 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" S_feature 18866..18974 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18944..18947 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18962..18981 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18976..19061 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18976 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" CDS 19062..19946 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" gene 19062..19946 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" S_feature complement(19194..19923) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19911..19929) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19923) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" promotor_-35 complement(19945..19950) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19968..20558 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" gene 19968..20558 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" misc_RNA 20611..20823 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene 20611..20823 /gene="tboS" /locus_tag="BSU_misc_RNA_1" downshifts 20788 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" CDS 20880..22157 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" gene 20880..22157 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" downshifts 22135 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" promotor_-35 22246..22253 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 22268..22287 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 22268 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" tRNA 22292..22384 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 22292..22384 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" downshifts 22407 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" S_feature 22452..22529 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22496..23149) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " gene complement(22496..23149) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" promotor_-35 22515..22521 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22520) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" S_feature 22531..23167 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22531 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 22535..22546 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(23146..23769) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" gene complement(23146..23769) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" promotor_-10 complement(23810..23829) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23828) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" promotor_-35 complement(23845..23849) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23868..25151) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" gene complement(23868..25151) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" downshifts complement(23905) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(25182..25200) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25203) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" promotor_-35 complement(25216..25221) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(25221..25766) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" gene complement(25221..25766) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" promotor_-35 25632..25636 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25651..25670 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25655..25851 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25657 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" promotor_-10 complement(25791..25809) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25810) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" promotor_-35 complement(25824..25830) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25852..26337 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" gene 25852..26337 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" promotor_-35 26341..26347 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 26379..26732 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" gene 26379..26732 /gene="scr" /locus_tag="BSU_misc_RNA_2" S_feature 26383..26532 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 26383 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" S_feature 26636..26731 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26688 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" promotor_-35 26752..26755 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26770..26789 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26779 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" CDS 26814..28505 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" gene 26814..28505 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" promotor_-35 28346..28353 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 28368..28387 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 28383 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" CDS 28529..28852 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" gene 28529..28852 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" CDS 28867..29463 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" gene 28867..29463 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" CDS 29481..29705 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" gene 29481..29705 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" promotor_-35 29708..29713 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29725 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" promotor_-10 29729..29747 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29772..30035 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" gene 29772..30035 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" promotor_-35 30048..30055 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 30069..30088 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 30076..30278 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 30076 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" rRNA 30279..31832 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 30279..31832 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" tRNA 31932..32008 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 31932..32008 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" tRNA 32020..32095 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 32020..32095 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" rRNA 32177..35103 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 32177..35103 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" S_feature 35104..35236 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 35237..35355 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 35237..35355 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" S_feature 35356..35458 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35419..35427 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35441..35460 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35460 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" CDS 35531..35725 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" gene 35531..35725 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" downshifts 35709 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" promotor_-35 35770..35779 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35791..35806 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35797 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" CDS 35845..36459 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" gene 35845..36459 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" CDS 36478..37638 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" gene 36478..37638 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" S_feature 37639..37719 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37720..39162 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" gene 37720..39162 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" promotor_-35 39082..39088 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 39103..39121 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 39112 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" CDS 39159..39797 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" gene 39159..39797 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" promotor_-35 39792..39799 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39812..39831 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39823 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" CDS 39871..40200 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" gene 39871..40200 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" CDS 40213..40653 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" gene 40213..40653 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" CDS 40665..41654 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" gene 40665..41654 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" CDS 41657..42484 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " gene 41657..42484 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" CDS 42499..42858 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" gene 42499..42858 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" CDS 42917..43660 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" gene 42917..43660 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" CDS 43647..43946 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" gene 43647..43946 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" CDS 43921..44799 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" gene 43921..44799 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" downshifts 44772 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" CDS complement(44848..45138) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" gene complement(44848..45138) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" downshifts complement(44850) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" downshifts 45169 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" promotor_-10 complement(45205..45224) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45222) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" S_feature complement(45224..45399) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(45238..45245) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(45395..45414) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(45399) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" promotor_-35 complement(45428..45435) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45499..45503 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45518..45537 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45524..45632 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45524 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" CDS 45633..47627 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" gene 45633..47627 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" promotor_-10 complement(46381..46400) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(46389) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(46416..46420) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47611 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" S_feature complement(47673..50019) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47706..48473 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" gene 47706..48473 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" S_feature 48474..48554 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48531..48536 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48552..48570 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48556 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-35 48581..48584 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48599..48618 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48616 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" CDS 48629..49942 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" gene 48629..49942 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" promotor_-35 48649..48656 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48667 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-10 48671..48690 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49903 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" promotor_-35 49965..49969 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49985..50004 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49987..50086 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49987 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-10 complement(50011..50026) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(50027) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" promotor_-35 complement(50038..50047) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 50083..50099 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 50087..50647 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" gene 50087..50647 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" upshifts 50097 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" CDS 50640..51518 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" gene 50640..51518 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" downshifts 51483 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" promotor_-35 51533..51542 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51556..51575 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51558..51679 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51558 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" CDS 51680..52552 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" gene 51680..52552 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" downshifts 52539 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" S_feature 52649..52719 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52710..52717 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52721 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" promotor_-10 52731..52750 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52740..52754) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52747) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(52763..52767) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52763..53023 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" gene 52763..53023 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" downshifts 52935 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" downshifts 53022 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" promotor_-35 53088..53094 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 53108..53119 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 53111..53182 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 53111 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" CDS 53183..53368 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" gene 53183..53368 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" downshifts 53353 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" S_feature complement(53363..55717) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53446..53450 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53466..53485 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53469 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" CDS 53516..54385 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" gene 53516..54385 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" CDS 54441..55298 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" gene 54441..55298 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" CDS 55295..55672 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" gene 55295..55672 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" downshifts 55662 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" promotor_-10 complement(55706..55724) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55707..55815 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55718) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" promotor_-35 complement(55740..55745) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55795..55803 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55814..55832 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55817 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" CDS 55866..56159 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" gene 55866..56159 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" downshifts 56148 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" S_feature 56193..56304 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 56286..56290 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 56306..56325 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 56306 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" CDS 56352..57722 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" gene 56352..57722 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" downshifts complement(57697) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" CDS 57745..58698 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" gene 57745..58698 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" promotor_-35 58711..58717 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58730 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" promotor_-10 58732..58750 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58783..59397 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" gene 58783..59397 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" downshifts 59381 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" CDS 59504..60070 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" gene 59504..60070 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" misc_feature 59683..59686 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59689 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" CDS 60130..60360 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" gene 60130..60360 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" S_feature 60361..60429 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60430..63963 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" gene 60430..63963 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" promotor_-35 63981..63987 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 64001..64098 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 64001..64012 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 64001 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" CDS 64099..64635 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" gene 64099..64635 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" downshifts 64639 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" misc_feature 64735..64754 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64746 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" CDS 64817..66415 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" gene 64817..66415 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" promotor_-35 66286..66293 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 66308..66327 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 66322 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" CDS 66405..67874 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" gene 66405..67874 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" promotor_-35 67046..67053 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 67067..67085 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 67081 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" promotor_no_box complement(67469..67569) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67509) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 67877..68137 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" gene 67877..68137 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" promotor_-35 68142..68147 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68163..68181 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68181 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" downshifts complement(68213) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" CDS 68216..68518 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" gene 68216..68518 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" CDS 68515..69150 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" gene 68515..69150 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" promotor_-35 69020..69029 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69042..69057 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69044 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" promotor_-35 69076..69084 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69095..69113 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69105 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" CDS 69168..69545 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" gene 69168..69545 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" CDS 69626..70012 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" gene 69626..70012 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" downshifts 70006 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" promotor_-35 70120..70127 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 70141..70160 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 70156 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" tRNA 70181..70257 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 70181..70257 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" tRNA 70267..70338 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 70267..70338 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" downshifts 70337 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" S_feature 70382..70493 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70489..70508 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70495 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" CDS 70538..73021 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" gene 70538..73021 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" downshifts 70579 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" S_feature complement(71190..71799) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(71216) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" promotor_-10 complement(71772..71790) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71798) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" promotor_-35 complement(71806..71811) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 72003..72009 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72024..72042 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72031 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" promotor_-35 73041..73044 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 73062..73079 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 73065 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" CDS 73106..73843 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" gene 73106..73843 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" CDS 73809..74825 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" gene 73809..74825 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" promotor_-35 74357..74363 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 74379..74397 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 74385 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" promotor_-35 74855..74862 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74876..74895 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74886 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 74929..76347 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" gene 74929..76347 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" promotor_-35 75724..75731 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75746..75765 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75749 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" downshifts complement(76342) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" CDS 76344..76886 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" gene 76344..76886 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" upshifts complement(76749) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(76751..76755) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76773..76776) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76887..76983 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76984..78897 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" gene 76984..78897 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" downshifts 78895 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" misc_feature complement(78934..78938) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78940..79025 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78942) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 79002..79009 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 79023..79042 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 79027..79091 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 79027 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 79092..79868 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" gene 79092..79868 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" CDS 79880..80755 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" gene 79880..80755 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" CDS 80802..81695 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" gene 80802..81695 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" promotor_-35 81425..81430 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81447..81465 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81448 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 81694..81701 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81716..81735 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81723 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 81771..82697 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" gene 81771..82697 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" downshifts 82690 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" promotor_-35 82744..82752 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82766..82774 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82768 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 82796..82799 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82814..82833 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82824 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" CDS 82864..84276 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" gene 82864..84276 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" promotor_-35 83666..83668 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83686..83704 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83692 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 84033..84040 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 84053..84072 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 84066 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" CDS 84290..84874 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" gene 84290..84874 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" CDS 84874..85755 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" gene 84874..85755 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" CDS 85737..86594 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" gene 85737..86594 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" CDS 86587..86949 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" gene 86587..86949 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" CDS 86946..87449 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" gene 86946..87449 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" CDS 87401..87610 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" gene 87401..87610 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" CDS 87634..88635 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " gene 87634..88635 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" S_feature complement(88050..89566) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88636..88726 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88727..90226 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" gene 88727..90226 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" promotor_-10 complement(89550..89568) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89566) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" promotor_-35 complement(89584..89589) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 90207 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" promotor_-35 90302..90309 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 90318..90535 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 90318 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" promotor_-10 90323..90342 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(90368) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" rRNA 90536..92089 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 90536..92089 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" rRNA 92254..95181 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 92254..95181 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" rRNA 95237..95354 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95237..95354 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" tRNA 95375..95450 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95375..95450 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" tRNA 95455..95530 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95455..95530 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" tRNA 95567..95642 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95567..95642 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" tRNA 95649..95731 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95649..95731 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" tRNA 95772..95846 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95772..95846 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" tRNA 95861..95946 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95861..95946 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" tRNA 95956..96032 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" gene 95956..96032 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" tRNA 96060..96136 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96060..96136 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" tRNA 96146..96221 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96146..96221 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" rRNA 96392..97945 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96392..97945 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" rRNA 98110..101037 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 98110..101037 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" rRNA 101093..101211 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 101093..101211 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" S_feature 101212..101289 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 101259..101262 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 101278..101297 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 101291 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-35 101325..101331 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 101345..101364 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 101356 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" promotor_-35 101371..101378 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 101392..101411 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 101404 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 101449..101913 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" gene 101449..101913 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" misc_feature complement(101560..101564) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101566) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 101927..102484 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" gene 101927..102484 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" CDS 102484..103575 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" gene 102484..103575 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" CDS 103572..106004 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" gene 103572..106004 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" downshifts 105999 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" CDS 106096..107472 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" gene 106096..107472 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" promotor_-35 106551..106560 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106573..106588 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106576 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 107476..108558 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" gene 107476..108558 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" S_feature 108559..108673 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108674..109774 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" gene 108674..109774 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" downshifts complement(109596) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" CDS 109789..110487 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" gene 109789..110487 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" CDS 110480..110956 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" gene 110480..110956 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" promotor_-35 110960..110967 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110981..111000 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110994 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 111047..112498 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" gene 111047..112498 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" promotor_-35 111976..111985 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111999..112018 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111999 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" S_feature 112499..112799 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112800..113453 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " gene 112800..113453 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" CDS 113450..114850 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" gene 113450..114850 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" CDS 114854..115285 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" gene 114854..115285 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" CDS 115269..116018 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" gene 115269..116018 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" CDS 116025..116537 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" gene 116025..116537 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" promotor_-35 116536..116543 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116558..116577 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116560 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 116600..117256 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" gene 116600..117256 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" downshifts complement(117054) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" S_feature 117257..117348 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 117349..117498 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" gene 117349..117498 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" CDS 117532..117711 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" gene 117532..117711 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" S_feature 117712..117889 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117883) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" CDS 117890..118423 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" gene 117890..118423 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" upshifts complement(117978) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(117981..117985) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(118000..118005) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118434..118441 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118452..118590 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118452 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 118455..118474 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118591..119016 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" gene 118591..119016 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" S_feature 119017..119110 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 119111..119809 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" gene 119111..119809 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" downshifts complement(119783) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" misc_RNA 119855..119995 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" gene 119855..119995 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" upshifts complement(119871) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(119874..119878) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119927 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" CDS 120061..120561 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" gene 120061..120561 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" CDS 120607..120978 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" gene 120607..120978 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" downshifts 120894 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" downshifts 120967 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" CDS 121068..121673 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" gene 121068..121673 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" promotor_-35 121668..121672 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121686..121918 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121686 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 121688..121707 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121919..125500 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" gene 121919..125500 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" promotor_-10 complement(123504..123523) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123507) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(123537..123546) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(124375..124379) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(124380) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(124394..124400) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125562..129161 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" gene 125562..129161 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" downshifts complement(128626) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" upshifts complement(128780) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(128798..128799) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(129110) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" S_feature 129162..129283 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 129265..129272 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 129285 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 129286..129305 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(129303..129307) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(129306) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 129340..129588 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" gene 129340..129588 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" S_feature 129589..129701 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129702..130118 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" gene 129702..130118 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" CDS 130160..130630 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" gene 130160..130630 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" CDS 130684..132762 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" gene 130684..132762 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" S_feature 132763..132881 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132882..134072 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" gene 132882..134072 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" downshifts 134067 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" misc_feature complement(134098..134101) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(134102) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 134128..134147 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 134136 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 134171..135127 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" gene 134171..135127 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" promotor_-35 135134..135141 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 135155..135174 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 135170..135363 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 135170 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" CDS 135364..135672 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" gene 135364..135672 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" CDS 135712..136341 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" gene 135712..136341 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" CDS 136369..136992 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" gene 136369..136992 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" CDS 136992..137279 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" gene 136992..137279 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" CDS 137311..138144 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" gene 137311..138144 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" downshifts complement(137447) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" CDS 138202..138480 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" gene 138202..138480 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" CDS 138497..138838 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" gene 138497..138838 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" CDS 138842..139498 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" gene 138842..139498 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" downshifts complement(138855) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(138936..138940) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138943) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(138957..138959) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139500..139934 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" gene 139500..139934 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" CDS 139924..140124 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" gene 139924..140124 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" CDS 140147..140410 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" gene 140147..140410 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" CDS 140451..140819 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" gene 140451..140819 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" CDS 140857..141168 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" gene 140857..141168 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" CDS 141195..141734 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" gene 141195..141734 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" CDS 141757..141942 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" gene 141757..141942 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" CDS 141974..142372 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" gene 141974..142372 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" downshifts complement(142375) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" CDS 142402..142941 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" gene 142402..142941 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" CDS 142974..143336 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" gene 142974..143336 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" CDS 143361..143861 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" gene 143361..143861 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" CDS 143875..144054 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" gene 143875..144054 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" CDS 144085..144525 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" gene 144085..144525 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" CDS 144527..145822 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" gene 144527..145822 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" CDS 145877..146530 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " gene 145877..146530 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" CDS 146527..147273 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" gene 146527..147273 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" CDS 147312..147536 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" gene 147312..147536 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" CDS 147585..147803 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" gene 147585..147803 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" CDS 147837..147950 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" gene 147837..147950 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" CDS 147973..148338 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" gene 147973..148338 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" CDS 148359..148754 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" gene 148359..148754 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" S_feature 148755..148930 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148931..149875 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" gene 148931..149875 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" CDS 149953..150315 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" gene 149953..150315 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" downshifts 150317 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" S_feature 150362..150442 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150443..151288 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" gene 150443..151288 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" CDS 151303..152133 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" gene 151303..152133 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" CDS 152130..152927 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" gene 152130..152927 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" CDS 152937..153680 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" gene 152937..153680 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" S_feature complement(153039..153507) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 153172..153177 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153192..153209 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153211 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" promotor_-10 complement(153507..153526) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153529) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" promotor_-35 complement(153539..153548) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153700..153706 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153721..153740 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153725 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" misc_RNA 153737..153793 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" gene 153737..153793 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" CDS 153842..154279 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" gene 153842..154279 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" CDS 154300..154692 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" gene 154300..154692 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" downshifts 154667 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" promotor_-35 154809..154816 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154830..154849 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154838..155119 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154838 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" misc_feature 155118..155137 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 155121 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" CDS 155156..155923 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" gene 155156..155923 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" downshifts 155914 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" promotor_-35 156053..156059 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156074..156085 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156081 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" CDS 156109..156552 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" gene 156109..156552 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" promotor_-35 156552..156557 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156573..156591 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156574 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" CDS 156612..157325 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" gene 156612..157325 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" upshifts 157370 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" misc_feature 157373..157392 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157421..158479 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" gene 157421..158479 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" S_feature complement(158050..158514) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158465 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" S_feature 158510..159181 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158515..159072) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" gene complement(158515..159072) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" promotor_-10 complement(159104..159115) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(159116) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" promotor_-35 complement(159129..159135) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(159149..159778) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 159182..159778 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" gene 159182..159778 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" S_feature 159779..160673 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159779..160543) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" gene complement(159779..160543) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" promotor_-10 complement(160574..160592) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160594) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" promotor_-35 complement(160608..160613) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160651..160658 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160673..160692 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160675..160892 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160675 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" rRNA 160893..162445 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 160893..162445 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" rRNA 162610..165535 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 162610..165535 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" rRNA 165591..165707 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165591..165707 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" tRNA 165754..165825 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165754..165825 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" tRNA 165830..165902 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165830..165902 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" tRNA 165959..166033 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165959..166033 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" tRNA 166064..166140 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166064..166140 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" tRNA 166168..166244 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166168..166244 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" tRNA 166253..166328 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166253..166328 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" rRNA 166500..168053 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166500..168053 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" rRNA 168218..171141 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 168218..171141 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" rRNA 171197..171314 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 171197..171314 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" rRNA 171498..173049 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 171498..173049 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" rRNA 173214..176141 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 173214..176141 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" rRNA 176197..176315 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 176197..176315 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" S_feature 176316..176924 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176892..176896 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176912..176931 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176926..177082 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176926 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" CDS 177083..178519 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" gene 177083..178519 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" downshifts 178508 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" promotor_-35 178562..178567 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178580..178599 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178598 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" CDS 178665..179585 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" gene 178665..179585 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" downshifts 179566 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" CDS complement(179595..180347) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" gene complement(179595..180347) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" downshifts complement(179619) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" CDS complement(180344..181354) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" gene complement(180344..181354) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" CDS complement(181347..182351) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" gene complement(181347..182351) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" CDS complement(182370..183323) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" gene complement(182370..183323) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" promotor_-35 182683..182689 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182704..182722 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182713 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(183354..183373) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(183361) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" CDS complement(183414..185003) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" gene complement(183414..185003) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" promotor_-10 complement(185044..185063) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(185056) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" promotor_-35 complement(185078..185085) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(185165) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" CDS complement(185194..186438) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" gene complement(185194..186438) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" downshifts complement(185215) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" CDS complement(186452..188380) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" gene complement(186452..188380) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" CDS complement(188408..189733) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" gene complement(188408..189733) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" CDS complement(189790..191157) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" gene complement(189790..191157) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" CDS complement(191183..192034) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" gene complement(191183..192034) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" CDS complement(192051..192965) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" gene complement(192051..192965) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" promotor_-10 complement(192996..193014) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193009) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" promotor_-35 complement(193030..193037) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(193075..193557) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" gene complement(193075..193557) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" CDS complement(193570..194025) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" gene complement(193570..194025) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" promotor_-10 complement(194051..194070) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(194072) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" promotor_-35 complement(194085..194086) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 194145..194152 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 194167..194186 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 194178 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" tRNA 194205..194279 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194205..194279 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" tRNA 194283..194358 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194283..194358 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" tRNA 194363..194435 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194363..194435 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" tRNA 194458..194542 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194458..194542 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" tRNA 194547..194621 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194547..194621 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" downshifts 194624 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" S_feature 194669..194786 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194787..194796 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194788 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" promotor_-10 194808..194823 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194849..195412 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" gene 194849..195412 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" CDS 195426..196052 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" gene 195426..196052 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" downshifts complement(195844) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(196002..196102) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 196032 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" upshifts complement(196042) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 196101..196108 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 196123..196142 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 196132..196212 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 196132 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" CDS 196213..197034 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" gene 196213..197034 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" CDS 197027..198478 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" gene 197027..198478 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" CDS 198497..199843 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" gene 198497..199843 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" downshifts 199838 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" promotor_-35 199862..199870 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199878 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" promotor_-10 199884..199903 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199930..199935 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199951..199970 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199957 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" misc_feature 200001..200017 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 200014 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" misc_RNA 200017..200187 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" gene 200017..200187 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" S_feature 200188..200276 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 200277..202079 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" gene 200277..202079 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" S_feature complement(201802..>202082) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 202065 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" SCAR join(202082,202128) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 202083..202127 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <202128..202246 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 202247..203224 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" gene 202247..203224 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" CDS 203226..203897 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" gene 203226..203897 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" promotor_-35 203791..203797 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203811..203830 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203829 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" CDS 203918..204880 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" gene 203918..204880 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" promotor_-35 204892..204894 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204910..204929 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204913 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" CDS 204939..205202 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" gene 204939..205202 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" downshifts 205143 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" CDS complement(205187..205957) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" gene complement(205187..205957) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" CDS complement(206043..206900) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" gene complement(206043..206900) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" downshifts complement(206065) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(206114..206133) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(206147..206156) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(206149) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(206913..206932) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206938) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" promotor_-35 complement(206947..206954) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206968..206975 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206989..207007 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206991 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" CDS 207032..208216 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" gene 207032..208216 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" downshifts 208202 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" promotor_-35 208370..208376 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 208390..208409 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208404..208533 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208404 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" CDS 208534..209922 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" gene 208534..209922 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" downshifts 209930 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" promotor_-35 209968..209974 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209988..209999 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209989 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" CDS 210034..210282 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" gene 210034..210282 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" CDS 210299..210490 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" gene 210299..210490 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" downshifts 210472 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" CDS complement(210517..211320) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" gene complement(210517..211320) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" promotor_-10 complement(211342..211360) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(211350) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" promotor_-35 complement(211371..211379) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211434..211440 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211455..211473 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211461 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" CDS 211493..212746 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" gene 211493..212746 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" misc_feature 211805..211812 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211815 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 212739 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" CDS complement(212787..213047) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" gene complement(212787..213047) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" downshifts complement(212806) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" promotor_-10 complement(213077..213095) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(213086) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" promotor_-35 complement(213109..213115) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 213239..213246 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 213256 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" promotor_-10 213262..213281 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 213316..214935 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" gene 213316..214935 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" downshifts 214918 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" CDS complement(214982..215863) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" gene complement(214982..215863) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" downshifts complement(214993) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" upshifts complement(215906) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" promotor_-10 complement(215915..215931) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215940..215946) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215962..217296) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" gene complement(215962..217296) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" promotor_-35 216944..216953 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216966..217592 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216966..216985 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216966 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" S_feature complement(217297..217369) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(217329..217429) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(217369) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" S_feature complement(217371..217457) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217447..217466) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217461) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" promotor_-35 complement(217479..217486) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217593..217841 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" gene 217593..217841 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" promotor_-35 217865..217872 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217872 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" promotor_-10 217888..217907 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217933..218850 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" gene 217933..218850 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" CDS 218847..220097 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" gene 218847..220097 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" downshifts 220087 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" CDS complement(220132..220416) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" gene complement(220132..220416) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo downshifts complement(220185) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" CDS complement(220322..220444) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" gene complement(220322..220444) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo S_feature complement(220417..220537) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220522..220540) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220537) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" S_feature complement(220539..220611) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220557..220562) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220612..221523) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" gene complement(220612..221523) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" S_feature complement(221524..221611) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221612..223810) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" gene complement(221612..223810) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" misc_feature complement(223845..223863) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223857) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" CDS complement(223885..224805) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" gene complement(223885..224805) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" CDS complement(224802..225629) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " gene complement(224802..225629) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" misc_feature complement(225656..225675) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225663) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" promotor_-35 225803..225806 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225821..225840 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225826 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" CDS 225860..227014 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" gene 225860..227014 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" downshifts 226995 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" promotor_-35 227075..227080 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 227089 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" promotor_-10 227095..227113 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 227129..227136 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 227151..227170 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 227151 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" CDS 227158..228099 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" gene 227158..228099 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" CDS 228062..228460 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" gene 228062..228460 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" promotor_-10 complement(228154..228168) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(228164) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(228184..228189) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228447 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" promotor_-35 228516..228523 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228538..228557 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228551..228625 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228551 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" CDS 228626..229516 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" gene 228626..229516 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" promotor_-35 228860..228867 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228876 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" promotor_-10 228881..228899 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229517..229711 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229712..230245 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" gene 229712..230245 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" CDS 230236..230724 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" gene 230236..230724 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" CDS 230717..231508 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" gene 230717..231508 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" downshifts 231483 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" CDS 231563..231841 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" gene 231563..231841 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" promotor_-35 231884..231893 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231902 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" promotor_-10 231906..231921 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231947..233287 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" gene 231947..233287 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" downshifts 233287 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" upshifts 233353 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" misc_feature 233356..233375 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 233395..234282 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" gene 233395..234282 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" S_feature 234283..234426 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 234398..234405 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234419..234438 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234428 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" CDS 234482..235450 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" gene 234482..235450 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" promotor_-10 complement(235304..235322) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(235321) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(235338..235343) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235447 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" downshifts complement(235486) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" CDS complement(235486..236730) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" gene complement(235486..236730) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" promotor_-10 complement(236764..236782) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236773) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" promotor_-35 complement(236793..236801) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236801..236819) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236817) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" promotor_-35 complement(236835..236840) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236875..238770) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" gene complement(236875..238770) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" downshifts complement(236891) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" misc_feature 238636..238655 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238653 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(238791..239540) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" gene complement(238791..239540) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" S_feature 239513..239694 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239541..239611) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239600..239619) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239615) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" promotor_-35 complement(239635..239642) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239681..239688 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239696 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" promotor_-10 239701..239720 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239759..240466 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" gene 239759..240466 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" promotor_-35 240432..240433 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240449..240463 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240459 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" CDS 240500..240775 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" gene 240500..240775 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" promotor_-10 complement(240558..240576) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240564) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(240591..240597) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240767 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" promotor_-35 240818..240822 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240838..240857 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240844 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" S_feature 240855..240983 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240984..242054 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" gene 240984..242054 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" downshifts 242043 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" CDS complement(242091..243503) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" gene complement(242091..243503) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" downshifts complement(242108) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" S_feature complement(243504..243615) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243588..243607) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243615) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" promotor_-35 complement(243622..243629) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243624..244571) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" gene complement(243624..244571) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" promotor_-10 complement(244609..244628) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244626) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" promotor_-35 complement(244643..244650) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244700..246136) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" gene complement(244700..246136) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" downshifts complement(244715) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" CDS complement(246159..247142) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" gene complement(246159..247142) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" promotor_-10 complement(247236..247253) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 247241..247260 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(247243) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 247247 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(247269..247276) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247444..248676 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" gene 247444..248676 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" CDS 248687..249631 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" gene 248687..249631 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" downshifts 249608 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" promotor_-35 249728..249735 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249740..249857 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249740 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" promotor_-10 249749..249768 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249858..250784 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" gene 249858..250784 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" CDS 250814..252280 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" gene 250814..252280 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" CDS 252364..253731 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" gene 252364..253731 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" CDS 253768..255135 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" gene 253768..255135 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" promotor_-35 255149..255156 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 255171..255188 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 255174 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" CDS 255205..255906 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" gene 255205..255906 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" downshifts 255856 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" downshifts 255900 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" CDS 255997..257529 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" gene 255997..257529 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" promotor_-35 257541..257544 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257559..257578 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257571..257805 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257571 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" CDS 257806..258726 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" gene 257806..258726 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" promotor_-35 258728..258735 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258750..258769 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258760 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" misc_RNA 258783..259030 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" gene 258783..259030 /gene="tboW" /locus_tag="BSU_misc_RNA_6" downshifts 258999 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" CDS 259128..259289 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" gene 259128..259289 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" promotor_no_box 259206..259306 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 259266 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 259310..260248 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" gene 259310..260248 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" downshifts 259354 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" misc_feature 260271..260290 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 260276..260344 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 260276 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" CDS 260345..261025 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" gene 260345..261025 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" CDS 261027..261962 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" gene 261027..261962 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" CDS 262054..262977 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" gene 262054..262977 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" S_feature complement(262524..263708) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262996..263682 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" gene 262996..263682 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" CDS complement(263643..263777) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" gene complement(263643..263777) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" downshifts 263677 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" CDS complement(263737..264123) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" gene complement(263737..264123) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" downshifts complement(263753) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(264149..264167) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264168) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" promotor_-35 complement(264181..264187) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(264201..265199) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(264244) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" promotor_-35 264380..264385 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 264399 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" promotor_-10 264401..264419 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264413) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" promotor_-10 complement(264415..264429) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264435) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" promotor_-35 complement(264437..264441) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264437..264865 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" gene 264437..264865 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" downshifts 264844 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" promotor_-35 264910..264916 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264929..264948 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264931 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" CDS 264971..265702 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" gene 264971..265702 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" promotor_-10 complement(265173..265192) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265199) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" promotor_-35 complement(265206..265213) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265620 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" CDS 265784..265960 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" gene 265784..265960 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" promotor_-35 265912..265918 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265925..265942 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265936 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" CDS 265979..267730 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" gene 265979..267730 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" promotor_-10 complement(266033..266048) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(266039) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(266061..266070) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267743..267955 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" gene 267743..267955 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" S_feature 267956..268015 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 268016..268744 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" gene 268016..268744 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" downshifts complement(268024) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" CDS complement(268741..269388) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" gene complement(268741..269388) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" promotor_-10 complement(269403..269422) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269416..269422 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269417) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" promotor_-10 269437..269456 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269437..269441) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 269439 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" CDS 269467..270579 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" gene 269467..270579 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" upshifts complement(269813) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(269816..269835) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269851..269855) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270573 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" CDS complement(270621..272060) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" gene complement(270621..272060) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" downshifts complement(270628) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" CDS complement(272100..272666) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" gene complement(272100..272666) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" promotor_-10 complement(272704..272723) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272718) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" promotor_-35 complement(272738..272745) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272820..272826 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272842..272859 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272848 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" CDS 272883..274010 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" gene 272883..274010 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" downshifts 273983 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" promotor_-35 274107..274113 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 274127..274146 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 274127 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" CDS 274173..274811 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" gene 274173..274811 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" downshifts 274797 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" S_feature 274842..275432 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274849..275232) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" gene complement(274849..275232) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" downshifts complement(274873) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(275262..275281) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(275269) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" promotor_-35 complement(275295..275302) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275404..275407 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275423..275442 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275434 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" CDS 275467..276543 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" gene 275467..276543 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" downshifts 276537 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" CDS complement(276583..277539) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" gene complement(276583..277539) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" downshifts complement(276611) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" CDS complement(277552..278253) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" gene complement(277552..278253) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" promotor_-10 complement(278277..278296) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(278283) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" promotor_-35 complement(278312..278315) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 278333..278336 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 278352..278371 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 278362 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" CDS 278397..279137 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" gene 278397..279137 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" CDS 279138..280298 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" gene 279138..280298 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" promotor_-35 280349..280357 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 280369..280387 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 280369 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" CDS 280434..281366 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" gene 280434..281366 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" CDS complement(281406..282470) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" gene complement(281406..282470) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" downshifts complement(281407) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" S_feature complement(282471..282661) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282493..282624) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " gene complement(282493..282624) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" promotor_-10 complement(282646..282665) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282666) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" promotor_-35 complement(282680..282687) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282798..284216 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" gene 282798..284216 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" promotor_-10 complement(284259..284277) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(284267) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(284291..284298) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 284323..284402 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 284323 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" promotor_-35 284325..284331 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 284346..284363 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284403..285764 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" gene 284403..285764 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" S_feature 285765..286345 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285772..286275) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" gene complement(285772..286275) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" S_feature complement(286276..286357) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 286347 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" promotor_-10 complement(286349..286368) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 286350..286369 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(286358) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" promotor_-35 complement(286381) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 286398..287519 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" gene 286398..287519 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" downshifts 287513 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" promotor_-35 287560..287566 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287581..287599 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287584 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" CDS 287626..288402 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" gene 287626..288402 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" downshifts complement(287633) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" CDS 288427..290112 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" gene 288427..290112 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" promotor_no_box 289367..289467 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289427 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 289493 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" downshifts 290109 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" promotor_-35 290203..290210 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290226..290245 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290232 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" CDS 290300..291259 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" gene 290300..291259 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" promotor_-35 290855..290861 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290875..290894 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290879 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" downshifts 291231 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" CDS 291315..292010 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" gene 291315..292010 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" CDS 291968..292810 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" gene 291968..292810 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" downshifts 292797 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" CDS complement(292848..293843) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" gene complement(292848..293843) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" promotor_-35 293799..293806 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293821..293840 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293827..294029 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293827 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" promotor_-10 complement(293875..293894) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293883) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" promotor_-35 complement(293909..293916) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 294013..294022 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 294031..294126 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 294031 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" promotor_-10 294035..294050 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 294127..294726 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" gene 294127..294726 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" CDS 294748..295329 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" gene 294748..295329 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" CDS 295364..295942 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" gene 295364..295942 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" CDS 295993..296766 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" gene 295993..296766 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" downshifts 296753 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" CDS 296851..298464 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" gene 296851..298464 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" CDS 298480..299571 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" gene 298480..299571 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" downshifts 299545 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" promotor_-35 299625..299632 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299647..299666 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299655 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" CDS 299693..300895 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" gene 299693..300895 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" downshifts 300875 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" CDS complement(301148..302320) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" gene complement(301148..302320) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" downshifts complement(301163) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" CDS complement(302389..302691) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" gene complement(302389..302691) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" downshifts complement(302417) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" promotor_-10 complement(302674..302693) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302693) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" promotor_-35 complement(302707..302713) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302940..302959 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302940 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" CDS 302981..304237 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" gene 302981..304237 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" downshifts complement(302989) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" CDS 304239..305087 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" gene 304239..305087 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" CDS 305087..305968 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" gene 305087..305968 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" downshifts 305949 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" downshifts complement(305981) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" CDS complement(306006..307157) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" gene complement(306006..307157) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" downshifts complement(306025) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" S_feature complement(307158..307245) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 307213..307220 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(307232..307251) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 307235..307254 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(307245) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" upshifts 307248 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" promotor_-35 complement(307264..307270) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 307307..308740 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" gene 307307..308740 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" promotor_-35 308045..308053 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308065..308083 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308084 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 308722 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" promotor_-35 308783..308790 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308805..308824 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308814 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" CDS 308856..309437 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" gene 308856..309437 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" upshifts 309250 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" misc_feature 309254..309258 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309413..309420 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309435..309454 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309448..309585 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309448 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" CDS 309586..311565 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" gene 309586..311565 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" downshifts 311579 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" promotor_-35 311645..311652 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311662 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" promotor_-10 311666..311685 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311742..312707 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" gene 311742..312707 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" CDS 312739..314364 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" gene 312739..314364 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" downshifts 312745 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" downshifts 314351 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" CDS complement(314409..315947) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" gene complement(314409..315947) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" downshifts complement(314427) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(315001..315101) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(315041) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 315961..315965 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315981..316000 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315995 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" promotor_-10 complement(316027..316046) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(316030) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" CDS 316060..316524 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" gene 316060..316524 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" promotor_-35 complement(316061..316067) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316534..316539 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316555..316573 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316565 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" CDS 316598..317227 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" gene 316598..317227 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" promotor_-35 317238..317247 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 317261..317280 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 317269 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" CDS 317297..318058 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" gene 317297..318058 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" S_feature complement(317697..318059) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 318055 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" CDS complement(318060..319400) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" gene complement(318060..319400) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" promotor_-10 complement(319427..319438) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319437) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" promotor_-35 complement(319453..319459) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319479..319485 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319493 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" promotor_-10 319500..319511 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319530..320126 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" gene 319530..320126 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" promotor_-35 320134..320141 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 320155..320255 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 320155..320174 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 320155 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" downshifts complement(320251) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" CDS 320256..321074 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" gene 320256..321074 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" downshifts 321056 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" CDS complement(321124..321717) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" gene complement(321124..321717) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" downshifts complement(321131) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" promotor_-10 complement(321732..321751) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321747) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(321766..321769) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321775..321923) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321825..321832 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321845..321864 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321847..321955 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321849 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" promotor_-10 complement(321917..321935) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321923..321930 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321933) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" promotor_-10 321945..321964 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321951..321956) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321957 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" CDS 321993..322553 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" gene 321993..322553 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" downshifts 322530 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" CDS complement(322581..323342) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" gene complement(322581..323342) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" downshifts complement(322605) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(323374..323393) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 323375..323382 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(323380) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" promotor_-10 323397..323416 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323408..323413) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323409 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" CDS 323460..324434 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" gene 323460..324434 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" S_feature 324435..324505 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324506..325462 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" gene 324506..325462 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" promotor_-35 324921..324927 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324942..324953 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324949 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" S_feature 325463..325541 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325516..325521 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325538..325556 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325543 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" CDS 325546..326328 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" gene 325546..326328 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" downshifts 326293 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" S_feature 326338..326465 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326442..326446 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326461..326480 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326467 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" CDS 326519..327430 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" gene 326519..327430 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" CDS 327447..328994 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" gene 327447..328994 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" promotor_-35 328418..328424 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328438..328457 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328446 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" promotor_-35 328529..328535 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328548..328567 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328557 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" misc_feature 328993..328997 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328995..329117 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328997 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" CDS 329118..330539 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" gene 329118..330539 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" S_feature complement(329638..331493) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330519 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" S_feature 330564..330660 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330631..330638 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330653..330672 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330662 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" CDS 330692..331927 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" gene 330692..331927 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" promotor_-10 complement(331486..331504) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331503) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" promotor_-35 complement(331518..331525) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331911) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" CDS complement(331964..332821) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" gene complement(331964..332821) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" downshifts complement(331977) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" CDS complement(332826..333710) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" gene complement(332826..333710) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" upshifts complement(333762) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" promotor_-10 complement(333767..333780) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333795..333803) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333810..334664) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" gene complement(333810..334664) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" promotor_-10 complement(334683..334702) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334703) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" promotor_-35 complement(334717..334720) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334754..334773 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334754..334772) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334761..334825 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334762 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" upshifts complement(334771) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(334788..334793) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334826..335836 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" gene 334826..335836 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" S_feature 335837..338284 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335868..337319) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" gene complement(335868..337319) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" downshifts complement(335872) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" CDS complement(337380..337700) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" gene complement(337380..337700) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" promotor_-35 337551..337556 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337570..337574 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337577 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(337609) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" promotor_-10 complement(337611..337630) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337644..337651) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337732..340149) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" gene complement(337732..340149) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" promotor_-10 complement(340174..340193) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(340188) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" promotor_-35 complement(340205..340211) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(340271..342403) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" gene complement(340271..342403) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" CDS complement(342410..344725) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" gene complement(342410..344725) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" promotor_no_box complement(344744..344844) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344784) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" promotor_-35 344827..344834 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344848..344867 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344860 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" CDS 344905..346110 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" gene 344905..346110 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" downshifts 346095 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" promotor_-35 346154..346160 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 346175..346194 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 346183 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" CDS 346227..347141 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" gene 346227..347141 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" CDS 347138..347722 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" gene 347138..347722 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" promotor_-35 347733..347740 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347754..347773 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347764 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" CDS 347818..348003 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" gene 347818..348003 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" CDS 348031..349224 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" gene 348031..349224 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" downshifts 349216 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" S_feature 349261..350930 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(349273..349953) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" gene complement(349273..349953) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" downshifts complement(349279) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" CDS complement(349963..350826) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" gene complement(349963..350826) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" promotor_-10 complement(350848..350867) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350860) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" S_feature complement(350862..353696) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350882..350889) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350899..350905 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350920..350938 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350932..351154 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350932 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" CDS 350988..351185 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" gene 350988..351185 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" promotor_-35 351123..351128 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351144..351162 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351156 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" CDS 351204..351659 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" gene 351204..351659 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" downshifts 351634 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" promotor_-35 351682..351688 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351695 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" promotor_-10 351702..351713 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351741..352073 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" gene 351741..352073 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" downshifts 352054 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" promotor_-35 352159..352166 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 352182..352201 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 352186 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" CDS 352227..353660 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" gene 352227..353660 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" downshifts 353638 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" CDS complement(353697..354095) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" gene complement(353697..354095) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" promotor_no_box complement(354092..354192) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(354122..354571) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" gene complement(354122..354571) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" upshifts complement(354132) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" promotor_-10 complement(354586..354605) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354594) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" S_feature complement(354596..354738) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354619..354626) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354739..356460) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" gene complement(354739..356460) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" promotor_-35 354751..354758 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354769..357912 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354769 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" promotor_-10 354773..354792 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354774..354874) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354814) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" promotor_-10 complement(356484..356502) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356499) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" promotor_-35 complement(356516..356523) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356571..357128) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" gene complement(356571..357128) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" downshifts complement(356574) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" CDS complement(357134..357766) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" gene complement(357134..357766) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" promotor_-10 complement(357792..357811) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357807) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" promotor_-35 complement(357826..357829) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357890..357893 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357908..357927 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357914 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" CDS 358000..358362 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" gene 358000..358362 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" downshifts 358346 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" promotor_-35 358609..358612 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358627..358646 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358635..358935 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358635 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" CDS 358936..369699 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" gene 358936..369699 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" CDS 369712..380463 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" gene 369712..380463 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" CDS 372848..372988 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" gene 372848..372988 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" CDS 380500..384327 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" gene 380500..384327 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" CDS 384356..385084 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" gene 384356..385084 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" downshifts 385066 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" promotor_-35 385122..385129 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 385132 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" promotor_-10 385141..385160 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 385185..386411 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" gene 385185..386411 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" downshifts 386405 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" CDS complement(386426..386983) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" gene complement(386426..386983) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" promotor_no_box complement(386441..386541) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386463) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" upshifts complement(386481) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(387012..387031) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(387014) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" CDS complement(387037..387975) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" gene complement(387037..387975) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" promotor_-10 complement(388014..388032) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(388021) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(388048..388053) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 388099..389433 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" gene 388099..389433 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" CDS complement(389428..389595) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" gene complement(389428..389595) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo CDS complement(389606..390103) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" gene complement(389606..390103) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo misc_feature complement(390130..390149) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(390142) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" CDS complement(390208..390855) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" gene complement(390208..390855) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" promotor_-10 complement(390884..390903) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390887) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" promotor_-35 complement(390919..390923) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(391024..391175) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(391176..391919) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" gene complement(391176..391919) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" downshifts complement(391232) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" CDS complement(391933..392637) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" gene complement(391933..392637) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" CDS complement(392624..393430) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" gene complement(392624..393430) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" promotor_-10 complement(393479..393498) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393491) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" promotor_-35 complement(393512..393519) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393546..394418) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" gene complement(393546..394418) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" promotor_-10 complement(394156..394174) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394163) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" promotor_-35 complement(394189..394195) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394472..394479 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394487..394506) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394493..394512 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394493) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" upshifts 394501 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" CDS 394508..395122 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" gene 394508..395122 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" promotor_-35 complement(394520..394527) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 395125..396546 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" gene 395125..396546 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" CDS 396563..396790 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" gene 396563..396790 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" CDS 396787..397251 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" gene 396787..397251 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" downshifts 397232 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" misc_feature 397258..397259 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 397259 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 397318..398163 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" gene 397318..398163 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" CDS complement(398203..399681) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" gene complement(398203..399681) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" downshifts complement(398211) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" promotor_-35 399708..399710 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399709..399728) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399719 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 399727..399745 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399729) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" S_feature complement(399731..400235) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399743..399750) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399899..399908 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399921..399940 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399922 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" CDS 399961..401715 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" gene 399961..401715 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" promotor_-10 complement(400232..400250) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(400245) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" promotor_-35 complement(400266..400271) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401706 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" CDS complement(401731..401952) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" gene complement(401731..401952) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" promotor_-10 complement(401971..401982) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401973) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" promotor_-35 complement(401997..402003) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 402018..402024 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402038..402049 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402051 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" CDS 402078..403712 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" gene 402078..403712 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" CDS 403702..404925 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" gene 403702..404925 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" CDS 404950..406071 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" gene 404950..406071 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" downshifts 406055 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" CDS complement(406176..406856) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" gene complement(406176..406856) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" CDS complement(406872..408332) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" gene complement(406872..408332) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" misc_feature 408502..408521 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408505 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" CDS 408545..409228 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" gene 408545..409228 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" CDS 409215..410636 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" gene 409215..410636 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" downshifts 410612 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" S_feature 410657..410761 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410751..410770 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410763 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" downshifts complement(410795) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" CDS 410799..411947 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" gene 410799..411947 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" promotor_-35 411647..411652 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411665 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" promotor_-10 411669..411687 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411809..411817 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411829..411847 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411841 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" CDS 411931..412053 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" gene 411931..412053 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" downshifts 412040 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" downshifts complement(412108) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" CDS complement(412153..412242) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" gene complement(412153..412242) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" downshifts complement(412313) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" CDS complement(412324..412437) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" gene complement(412324..412437) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" promotor_-10 complement(412458..412477) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412469) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" promotor_-35 complement(412490..412499) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412591..413955) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" gene complement(412591..413955) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" downshifts complement(412599) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" downshifts complement(412643) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(413991..414010) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(414007) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" promotor_-35 complement(414025..414032) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 414146..414150 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414166..414185 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 414178 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" promotor_-35 414209..414216 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414230..414249 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 414239..414339 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 414239 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" CDS 414340..415290 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" gene 414340..415290 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" CDS 415283..416230 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" gene 415283..416230 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" CDS 416224..416982 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" gene 416224..416982 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" CDS 417004..417957 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" gene 417004..417957 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" downshifts 417940 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" CDS complement(418004..419422) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" gene complement(418004..419422) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" downshifts complement(418025) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" CDS complement(419442..420320) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" gene complement(419442..420320) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" S_feature complement(420321..420387) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(420386..420405) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(420395) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" promotor_-35 complement(420420..420426) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420484..421233) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" gene complement(420484..421233) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" downshifts complement(420497) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" CDS complement(421250..421537) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" gene complement(421250..421537) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" promotor_-35 421503..421510 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421524..421543 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421543 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(421581..421600) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421597) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" promotor_-35 complement(421614..421621) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421642..421649 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421654 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" promotor_-10 421660..421679 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421677..421991 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" gene 421677..421991 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" downshifts 421983 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" CDS complement(421993..423432) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" gene complement(421993..423432) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" promotor_-10 complement(422317..422328) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(422323) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(422342..422348) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423475..423494) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423476..423483 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423482) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 423497..423516 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423501 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" promotor_-35 complement(423505..423512) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423539..424849 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" gene 423539..424849 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" promotor_-35 424727..424733 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424747..424765 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424755 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" promotor_-35 424851..424858 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424873..424892 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424882 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" CDS 424918..426306 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" gene 424918..426306 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" downshifts 426314 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" promotor_-35 426364..426370 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 426384..426395 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 426385 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" CDS 426429..427292 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" gene 426429..427292 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" CDS 427312..428097 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" gene 427312..428097 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" misc_feature 427417..427436 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427417 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 427505 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" downshifts 428099 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" CDS complement(428142..428756) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" gene complement(428142..428756) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" downshifts complement(428153) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" CDS complement(428769..430394) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" gene complement(428769..430394) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" CDS complement(430429..431001) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" gene complement(430429..431001) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" promotor_-10 complement(431023..431042) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(431038) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" promotor_-35 complement(431056..431063) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 431123..431142 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 431135 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" CDS 431166..431519 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" gene 431166..431519 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" downshifts 431490 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" promotor_-35 431583..431590 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431604..431623 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431609 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" S_feature 431619..431691 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431692..433128 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" gene 431692..433128 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" CDS 433153..433584 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" gene 433153..433584 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" CDS 433586..434707 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" gene 433586..434707 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" downshifts 434690 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" promotor_-35 434736..434739 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434755..434774 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434757 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" CDS 434798..435862 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" gene 434798..435862 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" promotor_-35 435032..435040 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435054..435073 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435064 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 435856 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" promotor_-35 435929..435936 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435949..435968 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435962 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" CDS 435997..436560 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" gene 435997..436560 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" S_feature 436561..437285 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436620..437228) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" gene complement(436620..437228) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" misc_feature complement(437246..437265) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 437262..437268 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(437269) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" promotor_-10 437281..437300 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437287 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" CDS 437314..437706 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" gene 437314..437706 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" downshifts 437683 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" CDS complement(437739..437903) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" gene complement(437739..437903) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" downshifts complement(437759) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(437913..437931) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437935) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" promotor_-35 complement(437946..437952) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437965..437972 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437986..438005 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437989 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" CDS 438036..438785 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" gene 438036..438785 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" downshifts 438762 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" downshifts complement(438838) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" promotor_-35 438868..438874 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438888..438907 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438894..438990 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438894 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" CDS 438991..439764 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" gene 438991..439764 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" CDS 439779..440993 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" gene 439779..440993 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" CDS 441017..441790 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" gene 441017..441790 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" CDS 441835..442557 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" gene 441835..442557 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" CDS 442560..443567 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" gene 442560..443567 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" downshifts 443053 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" promotor_no_box 443147..443247 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 443207 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" CDS 443583..444335 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" gene 443583..444335 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" promotor_-35 444333..444342 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444356..444375 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444366 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" CDS 444399..445040 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" gene 444399..445040 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" downshifts 445026 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" S_feature complement(445038..445463) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(445083) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" promotor_-35 445116..445122 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445136..445155 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445137 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" CDS 445213..445458 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" gene 445213..445458 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" S_feature 445459..445869 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445464..445751) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" gene complement(445464..445751) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" misc_feature complement(445772..445791) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445788) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" promotor_-35 445845..445849 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445866..445885 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445871 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" CDS 445902..447908 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" gene 445902..447908 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" S_feature 447909..448009 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 448010..448912 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" gene 448010..448912 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" downshifts 448892 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" promotor_-35 448985..448992 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 449006..449025 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 449010..449097 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 449010 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" CDS 449098..451182 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" gene 449098..451182 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" downshifts 451169 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" promotor_-35 451211..451217 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 451231..451249 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 451243 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" S_feature 451254..451335 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 451297..451304 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 451318..451337 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 451337 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" CDS 451394..452905 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" gene 451394..452905 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" downshifts 452889 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" CDS complement(452925..453470) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" gene complement(452925..453470) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" downshifts complement(452958) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(453537..453555) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453551) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" promotor_-35 complement(453570..453576) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453612..453618 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453630 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" promotor_-10 453633..453651 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453677..454537 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" gene 453677..454537 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" CDS 454553..455056 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" gene 454553..455056 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" downshifts 455037 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" promotor_-35 455085..455092 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455106..455125 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455108 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" CDS 455142..455693 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" gene 455142..455693 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" promotor_-35 455708..455714 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455729..455747 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455742 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" CDS 455771..456193 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" gene 455771..456193 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" promotor_-35 456198..456206 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456217..456236 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 456236..456602 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 456236 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" promotor_no_box complement(456262..456362) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(456297..456565) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" gene complement(456297..456565) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" upshifts complement(456302) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 456559 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" promotor_-35 456639..456648 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456661..456676 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456666 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" CDS 456699..457508 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" gene 456699..457508 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" downshifts 457489 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" CDS complement(457552..457842) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" gene complement(457552..457842) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" downshifts complement(457556) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" misc_feature complement(457870..457889) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457870..457888 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457876 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(457886) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" promotor_-35 457964..457971 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457985..458004 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457989 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" CDS 458027..458461 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" gene 458027..458461 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" promotor_-35 458458..458461 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458470 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" promotor_-10 458478..458497 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458526..460709 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" gene 458526..460709 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" downshifts 460692 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" promotor_-35 460758..460764 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460779..460797 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460780..460911 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460780 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" CDS 460912..462000 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" gene 460912..462000 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" CDS 461981..462832 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" gene 461981..462832 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" CDS 462843..464552 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" gene 462843..464552 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" CDS 464545..465807 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" gene 464545..465807 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" CDS 465813..467924 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" gene 465813..467924 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" downshifts 467908 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" promotor_-35 468021..468028 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468043..468062 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 468050 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" misc_RNA 468060..468203 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" gene 468060..468203 /gene="swaO" /locus_tag="BSU_misc_RNA_7" downshifts 468201 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" S_feature 468246..468399 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 468400..470223 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" gene 468400..470223 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" downshifts 470215 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" CDS 470282..470731 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" gene 470282..470731 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" promotor_-35 470744..470750 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470765..470783 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470766 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" CDS 470798..472522 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" gene 470798..472522 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" S_feature complement(471634..472493) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472495..472606) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472506 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" CDS complement(472514..472717) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" gene complement(472514..472717) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" downshifts complement(472538) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" promotor_no_box complement(472566..472666) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472575..472580 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472597..472615 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472606) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" S_feature 472607..472822 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472607 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" S_feature complement(472673..472744) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472716) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" CDS complement(472745..473011) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" gene complement(472745..473011) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" promotor_-10 complement(473027..473046) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(473045) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" promotor_-35 complement(473058..473065) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(473115..474392) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" gene complement(473115..474392) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" downshifts complement(473134) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(474454..474473) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474466) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" S_feature complement(474468..474545) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474486..474493) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474529..474548) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474545) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" promotor_-35 complement(474562..474571) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474622..474879) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" gene complement(474622..474879) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" downshifts complement(474630) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" downshifts complement(474696) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" CDS complement(474957..475409) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" gene complement(474957..475409) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" promotor_-10 complement(475428..475446) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475445) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" promotor_-35 complement(475460..475466) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475478 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" misc_feature 475486..475505 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475527..476345 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" gene 475527..476345 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" downshifts 476336 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" promotor_-35 476413..476419 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476433..476451 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476441 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" CDS 476474..476845 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" gene 476474..476845 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" downshifts complement(476478) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" downshifts 476862 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" upshifts complement(476896) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(476899..476902) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476924..476931 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476943..476962 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476950 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" CDS 476977..477318 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" gene 476977..477318 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" CDS 477312..477671 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" gene 477312..477671 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" S_feature complement(477374..477667) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477612 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" downshifts 477656 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" CDS complement(477708..478529) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" gene complement(477708..478529) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" downshifts complement(477712) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" promotor_-10 complement(478551..478569) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478572) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" promotor_-35 complement(478583..478589) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478614..479666) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" gene complement(478614..479666) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" promotor_-35 478926..478933 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478948..479735 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478948..478967 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478949 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" promotor_-10 complement(479679..479698) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479684) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" promotor_-35 complement(479712..479719) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479736..481343 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" gene 479736..481343 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" CDS 481333..482013 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" gene 481333..482013 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" S_feature 482014..482088 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 482055..482062 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482077..482094 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 482090 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" CDS 482134..483399 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" gene 482134..483399 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" downshifts 483392 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" downshifts complement(483446) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" misc_feature 483483..483500 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483485 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" CDS 483547..484599 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" gene 483547..484599 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" S_feature 484600..484843 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484800 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" CDS 484876..485802 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" gene 484876..485802 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" CDS 485822..486562 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" gene 485822..486562 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" misc_feature 486621..486640 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486626 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" CDS 486657..486992 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" gene 486657..486992 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" downshifts 486967 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" S_feature 487012..487081 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 487047..487054 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 487068..487087 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 487082 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" CDS 487120..488265 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" gene 487120..488265 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" downshifts 488247 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" CDS complement(488290..488469) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" gene complement(488290..488469) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" downshifts complement(488308) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" CDS complement(488423..488587) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" gene complement(488423..488587) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" S_feature complement(488470..488638) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488630..488649) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488640) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" promotor_-35 complement(488664..488671) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488779..488784 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488800..488818 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488804 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" CDS 488834..489706 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" gene 488834..489706 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" promotor_-35 489070..489079 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489092..489107 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 489095 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" S_feature complement(489651..489720) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489694) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" S_feature 489707..490056 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489721..490041) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" gene complement(489721..490041) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" promotor_-35 490037..490041 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 490050..490064 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 490058..490215 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 490058 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" promotor_-10 complement(490062..490081) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(490077) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" promotor_-35 complement(490095..490102) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 490216..491280 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" gene 490216..491280 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" downshifts 491268 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" CDS 491352..492725 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" gene 491352..492725 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" promotor_-35 492756..492762 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492776..492787 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492786 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" misc_feature 492829..492848 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492830..493004 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492830 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" promotor_-35 492972..492979 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492994..493013 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 493006..493073 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 493006 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" CDS 493125..494609 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" gene 493125..494609 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" downshifts 494602 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" S_feature 494722..494781 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494722..494731 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494724 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" promotor_-10 494743..494758 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494782..495261 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " gene 494782..495261 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" CDS 495251..496732 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" gene 495251..496732 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" downshifts 496702 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" S_feature 496747..497074 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496756) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" CDS complement(496984..497583) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" gene complement(496984..497583) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" promotor_-35 497044..497049 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 497062..497081 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 497076..497677 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 497076 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" misc_feature complement(497607..497626) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497618) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" CDS 497678..498043 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" gene 497678..498043 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" promotor_-35 498046..498051 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 498067..498208 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 498067..498085 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 498067 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" CDS 498209..499225 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" gene 498209..499225 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" downshifts 499210 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" promotor_-35 499270..499277 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 499291..499310 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 499298 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 499340..500509 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" gene 499340..500509 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" promotor_-35 500438..500443 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500458..500476 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500464 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" promotor_-35 500539..500542 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500558..500577 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500559 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 500625..500906 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" gene 500625..500906 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" CDS 500911..501261 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" gene 500911..501261 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" S_feature complement(501051..501527) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(501094) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" downshifts 501241 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" promotor_-35 501295..501302 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 501316..501335 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 501324 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 501376..502200 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" gene 501376..502200 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" promotor_-10 complement(501510..501528) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501527) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" S_feature complement(501529..502128) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501542..501549) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(502117..502135) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502128) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" S_feature complement(502130..502718) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(502149..502155) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502205..502570 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" gene 502205..502570 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" CDS 502574..502975 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" gene 502574..502975 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" promotor_-10 complement(502716..502735) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502733) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" promotor_-35 complement(502749..502758) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502987..503994 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" gene 502987..503994 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" promotor_-35 503988..503994 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 504009..504027 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 504015 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 504056..504385 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" gene 504056..504385 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" CDS 504382..504864 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" gene 504382..504864 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" CDS 504830..505618 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" gene 504830..505618 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" CDS 505618..506217 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" gene 505618..506217 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" downshifts 506203 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" promotor_-35 506261..506267 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506282..506301 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 506294 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 506328..506444 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" gene 506328..506444 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" CDS 506460..506753 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" gene 506460..506753 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" promotor_-35 506721..506729 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506741..506760 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506750..507190 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" gene 506750..507190 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" upshifts 506756 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" S_feature complement(506989..510044) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 507174..507617 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" gene 507174..507617 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" downshifts 507592 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" promotor_-35 507648..507649 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507665..507684 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507665 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" CDS 507711..509870 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" gene 507711..509870 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" misc_feature 509858..509877 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509880..510096 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509880 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" CDS complement(509880..509993) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" gene complement(509880..509993) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" promotor_-10 complement(510033..510052) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(510050) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" promotor_-35 complement(510067..510075) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 510097..510549 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" gene 510097..510549 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" promotor_-35 510555..510561 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510576..510595 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510584..510671 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510584 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" downshifts complement(510616) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" tRNA 510672..510746 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510672..510746 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" tRNA 510751..510841 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510751..510841 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" tRNA 510871..510942 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510871..510942 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" tRNA 510954..511028 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510954..511028 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" tRNA 511055..511130 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 511055..511130 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" tRNA 511142..511223 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 511142..511223 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" downshifts 511288 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" tRNA 511304..511390 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 511304..511390 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" downshifts 511377 /Source="Nicolas_upshifts" /id="D229" /incds=0 /nref=82 /ntot=235 /MaxReadThrough="4.38481" /MaxDrop="5.23398" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=89 /isTUend="FALSE" S_feature 511422..512320 /Source="Nicolas_S_feature" /locus_tag="new_529454_530352" /HighExp="Cold, G180, G135, Paraq, Oxctl, C30, G150, H2O2, Fru, Lbexp" /AntisenseName="ydcL" /AntisenseCor="-0.23338643759911901" /AntisenseRegPval="-4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S169" downshifts complement(511445) /Source="Nicolas_upshifts" /id="D230" /incds=0 /nref=96 /ntot=231 /MaxReadThrough="2.93365" /MaxDrop="6.05127" /score="8.78044068" /energy="-9.2" /TU="U381" /idTUdmin="U381" /TUdmin="-125" /isTUend="FALSE" CDS complement(511473..512579) /gene="ydcL" /locus_tag="BSU_04800" /old_locus_tag="BSU04800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22505685; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: integrase" /protein_id="NP_388361.1" /db_xref="EnsemblGenomes-Gn:BSU04800" /db_xref="EnsemblGenomes-Tr:CAB12287" /db_xref="GOA:P96629" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG12099" /db_xref="UniProtKB/Swiss-Prot:P96629" /translation="MSVKKLENGQYQVDVSFGFDPITGERIRTRPVASTRKEALELEA KLRREFQEERARKSRSVSFPTLISIYLASCEIDSKPNYYQNQKYIINKHISDYFLKSD IQKITHREITDFRKHLMETGLSNKSVNNIMTSLSKIFDTAVHEEILKRNPCDNVKRLP LTRKKMKFWRPEEFKKFISLIPQDQLLFKTFYTVAFLTGLRCGEMLALQWKDIDKILL EIDVHKSCTWLDGQFVVTTPKTKNSIRRVSINKKLLKLLERWKEAQEELFNELGIRHS HDTYIFQYKDTPSRKDIFSRKIKYFCKDSDLTPIRLHDFRHSHVALLIHQGEDYITIK ERLGHGSVKTTIDVYGHLYPNKQKEMADKLDDLL*" gene complement(511473..512579) /gene="ydcL" /locus_tag="BSU_04800" /old_locus_tag="BSU04800" CDS complement(512592..513101) /gene="immA" /locus_tag="BSU_04810" /old_locus_tag="BSU04810" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:18761623, 21036995, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18761623, 21036995, 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: site-specific protease cleaving ImmR" /protein_id="NP_388362.1" /db_xref="EnsemblGenomes-Gn:BSU04810" /db_xref="EnsemblGenomes-Tr:CAB12288" /db_xref="GOA:P96630" /db_xref="InterPro:IPR010359" /db_xref="SubtiList:BG12100" /db_xref="UniProtKB/Swiss-Prot:P96630" /translation="MITIYTSKGIKHKVQSVIKTHGTNNVYEICDIQKIYILKNDLGQ ANGLLQHDKATDQYLIHINENLQHQQFVIAHELGHYFLHKRLNTFKVVNCSKVLKDKL EHQASLFASELILTDKMLNEALPYIQGFSKEQIAAYFNVPSFVTDYKLSQIGSFSNRI YSHEISAFG*" gene complement(512592..513101) /gene="immA" /locus_tag="BSU_04810" /old_locus_tag="BSU04810" downshifts complement(512904) /Source="Nicolas_upshifts" /id="D231" /incds=1 /nref=12 /ntot=39 /MaxReadThrough="6.14325" /MaxDrop="3.22989" /score="17.0287275" /energy="-11.8" /TU="U381" /idTUdmin="U384" /TUdmin=1518 /isTUend="FALSE" CDS complement(513098..513481) /gene="immR" /locus_tag="BSU_04820" /old_locus_tag="BSU04820" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8083175, 17511812, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8083175, 17511812, 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: transcriptional regulator(Xre family)" /protein_id="NP_388363.1" /db_xref="EnsemblGenomes-Gn:BSU04820" /db_xref="EnsemblGenomes-Tr:CAB12289" /db_xref="GOA:P96631" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG12101" /db_xref="UniProtKB/Swiss-Prot:P96631" /translation="MSLGKRLKEARQKAGYTQKEAAEKLNIGNNNLSNYERDYRDPDT DTLLKLSNLYNVSTDYLLGKDEVSKKNETDLLNKTINEAIQELKDEDTLLFMNDGEFD EETARLVKKALKNGIKFIDELKKKE*" gene complement(513098..513481) /gene="immR" /locus_tag="BSU_04820" /old_locus_tag="BSU04820" promotor_-10 complement(513510..513529) /Source="Nicolas_upshift_promotors" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(513522) /Source="Nicolas_upshifts" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" promotor_-35 complement(513544..513551) /Source="Nicolas_upshift_promotors" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 513681..513688 /Source="Nicolas_upshift_promotors" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /label="promotor_-35" promotor_-10 513703..513722 /Source="Nicolas_upshift_promotors" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /label="promotor_-10" upshifts 513708 /Source="Nicolas_upshifts" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" CDS 513755..513949 /gene="xis" /locus_tag="BSU_04830" /old_locus_tag="BSU04830" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3269394, 17511812, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3269394, 17511812, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: excisionase" /protein_id="NP_388364.1" /db_xref="EnsemblGenomes-Gn:BSU04830" /db_xref="EnsemblGenomes-Tr:CAB12290" /db_xref="GOA:O31490" /db_xref="SubtiList:BG12670" /db_xref="UniProtKB/Swiss-Prot:O31490" /translation="MKGEFLTARDIQKILGVKQAKSYDIIRTLNAQMKEEGYMVIQGK VSRAKFEECYCYKGPKSQTG*" gene 513755..513949 /gene="xis" /locus_tag="BSU_04830" /old_locus_tag="BSU04830" CDS 513946..514206 /gene="ydzL" /locus_tag="BSU_04839" /old_locus_tag="BSU04839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685, 26013486; Product type h:extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="YP_003097681.1" /db_xref="EnsemblGenomes-Gn:BSU04839" /db_xref="EnsemblGenomes-Tr:CAX52552" /db_xref="UniProtKB/Swiss-Prot:C0H3V5" /translation="MIFINIDITNSFMKEAVPLARQMEGDWIARMKIALNSVIINHYL NLPLTIENVNELLRKGVSYRRICKHYGIGRKDIEKLRQSSVV*" gene 513946..514206 /gene="ydzL" /locus_tag="BSU_04839" /old_locus_tag="BSU04839" CDS 514260..514520 /gene="ydcO" /locus_tag="BSU_04840" /old_locus_tag="BSU04840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685, 26013486; Product type h:extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388365.1" /db_xref="EnsemblGenomes-Gn:BSU04840" /db_xref="EnsemblGenomes-Tr:CAB12291" /db_xref="SubtiList:BG12102" /db_xref="UniProtKB/Swiss-Prot:P96632" /translation="MKIRVNATIITDVEALKADKDLNHFKDYATCETFVVDADNHLKA NEEISELLKGWDWWCIWSTRPLSKKDNQVFTLYNDDLYNLCR*" gene 514260..514520 /gene="ydcO" /locus_tag="BSU_04840" /old_locus_tag="BSU04840" S_feature complement(514380..514620) /Source="Nicolas_S_feature" /locus_tag="new_532412_532652_c" /HighExp="T5.0H, T4.0H, T3.0H, Lbstat, T3.30H, T2.0H, Cold, Gly, S2, T2.30H" /AntisenseName="ydcO" /AntisenseCor="0.131178357364787" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S170" promotor_-35 514546..514553 /Source="Nicolas_upshift_promotors" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(514551..514610) /gene="sncO" /locus_tag="BSU_misc_RNA_65" /product="ICEBs1 mobile element: conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796, 22505685; Product type n: RNA" gene complement(514551..514610) /gene="sncO" /locus_tag="BSU_misc_RNA_65" promotor_-10 514568..514587 /Source="Nicolas_upshift_promotors" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 514572..514889 /Source="Nicolas_S_feature" /locus_tag="new_532604_532921" /HighExp="T0.30H, T0.0H, T1.0H, T1.30H, T-0.40H, T2.0H, HiOs, T2.30H, MG 120, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S171" upshifts 514572 /Source="Nicolas_upshifts" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" promotor_-10 complement(514605..514624) /Source="Nicolas_upshift_promotors" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(514620) /Source="Nicolas_upshifts" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" promotor_-35 complement(514638..514645) /Source="Nicolas_upshift_promotors" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" /label="promotor_-35" CDS 514726..514854 /locus_tag="BSU_04849" /old_locus_tag="BSU04849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 22505685" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: hypothetical protein" /protein_id="YP_009513947.1" /translation="MMAIISLLGCHEGVKPLATDKRQDGYRTGANQKHKIEINVLL*" gene 514726..514854 /locus_tag="BSU_04849" /old_locus_tag="BSU04849" CDS 514890..515270 /gene="helP" /locus_tag="BSU_04850" /old_locus_tag="BSU04850" /experiment="publication(s) with functional evidences, PMID:22505685, 23326247, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 23326247, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: helicase processivity factor" /protein_id="NP_388366.1" /db_xref="EnsemblGenomes-Gn:BSU04850" /db_xref="EnsemblGenomes-Tr:CAB12292" /db_xref="InterPro:IPR010365" /db_xref="SubtiList:BG12103" /db_xref="UniProtKB/Swiss-Prot:P96633" /translation="MNLNFIVPDINMTFGDMKFMGLNRERYVYDRENNKRTDVLESRI YNIASAVQGGQIEVTIPEYAGAKEIPPFADIELKNPKISAMATSQRDSTYANVMWKLE ADDIVVKGGSSVKPAAATGGNEKK*" gene 514890..515270 /gene="helP" /locus_tag="BSU_04850" /old_locus_tag="BSU04850" CDS 515306..516748 /gene="conQ" /locus_tag="BSU_04860" /old_locus_tag="BSU04860" /experiment="publication(s) with functional evidences, PMID:17511812, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17511812, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: coupling conjugation protein VirD4" /protein_id="NP_388367.1" /db_xref="EnsemblGenomes-Gn:BSU04860" /db_xref="EnsemblGenomes-Tr:CAB12293" /db_xref="GOA:P96634" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12104" /db_xref="UniProtKB/Swiss-Prot:P96634" /translation="MSDFLNKRFWKYRGKRIRPYMRNNVKLAGAIIFVPVFLLSMFLF WREQLIHFDLSQVIKNFEWNVPLIIKSVLCSVLIAVGSIVASYFLLFDSYKKILHRQK IAKMIFSNKFYEKENVKVRKIFSNETDSKEKITYFPRMYYQVKNNHIYIRIAMDMSRF QNRFLDLGKDLENGLFCDLVDKQMEEGFVCFKLLYDVKKNRISIDDAVAENGVLPLMK HISWQFDKLPHMLIAGGTGGGKTYFMLTIIKACVGLGADVRILDPKNADLADLEEVLP KKVYSQKNGILMCLRKSVDGMMERMDEMKQMSNYKTGENYAYLGLKPVFIFFDEYVAF MDLLDMKERNEALSYMKQLVMLGRQAGYFLVLGAQRPDAKYLADGIRDQFSFRVSLGL MSDTGYGMMFGDVEKAYVNKKETGRGYANVGTGSVLEFYSPIVPKGYDFMSSIKNALV GVEGAQATAVASGSVSDQTASGEGVSEANG*" gene 515306..516748 /gene="conQ" /locus_tag="BSU_04860" /old_locus_tag="BSU04860" CDS 516741..517799 /gene="nicK" /locus_tag="BSU_04870" /old_locus_tag="BSU04870" /experiment="publication(s) with functional evidences, PMID:17511812, 17693500, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17511812, 17693500, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: DNA relaxase" /protein_id="NP_388368.1" /db_xref="EnsemblGenomes-Gn:BSU04870" /db_xref="EnsemblGenomes-Tr:CAB12294" /db_xref="GOA:P96635" /db_xref="InterPro:IPR003491" /db_xref="SubtiList:BG12105" /db_xref="UniProtKB/Swiss-Prot:P96635" /translation="MDELKQPPHANRGVVIVKEKNEAVESPLVSMVDYIRVSFKTHDV DRIIEEVLHLSKDFMTEKQSGFYGYVGTYELDYIKVFYSAPDDNRGVLIEMSGQGCRQ FESFLECRKKTWYDFFQDCMQQGGSFTRFDLAIDDKKTYFSIPELLKKAQKGECISRF RKSDFNGSFDLSDGITGGTTIYFGSKKSEAYLCFYEKNYEQAEKYNIPLEELGDWNRY ELRLKNERAQVAIDALLKTKDLTLIAMQIINNYVRFVDADENITREHWKTSLFWSDFI GDVGRLPLYVKPQKDFYQKSRNWLRNSCAPTMKMVLEADEHLGKTDLSDMIAEAELAD KHKKMLDVYMADVADMVV*" gene 516741..517799 /gene="nicK" /locus_tag="BSU_04870" /old_locus_tag="BSU04870" downshifts 516744 /Source="Nicolas_upshifts" /id="D232" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="5.48512" /MaxDrop="3.25403" /score="-9.5933493" /energy="-23.1" /TU="U382,U383" /idTUdmin="U382" /TUdmin="-176" /isTUend="FALSE" S_feature 517800..518063 /Source="Nicolas_S_feature" /locus_tag="new_535832_536095" /HighExp="T0.30H, T1.0H, T1.30H, T0.0H, T2.0H, T2.30H, T-0.40H, T3.0H, T3.30H, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigA" /TUlongPSig=1 /label="S172" CDS 518064..518333 /gene="ydcS" /locus_tag="BSU_04880" /old_locus_tag="BSU04880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388369.1" /db_xref="EnsemblGenomes-Gn:BSU04880" /db_xref="EnsemblGenomes-Tr:CAB12295" /db_xref="SubtiList:BG12106" /db_xref="UniProtKB/Swiss-Prot:P96636" /translation="MHNVNLLNQAGLENALESVGCLDIVEDLIEKMQEYVLYHTETAE RFAIDIFTVVNNYTKKVHAIFNVLENEDGETNVKNVEFEVMHFTE*" gene 518064..518333 /gene="ydcS" /locus_tag="BSU_04880" /old_locus_tag="BSU04880" promotor_-10 complement(518124..518143) /Source="Nicolas_upshift_promotors" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(518140) /Source="Nicolas_upshifts" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(518158..518165) /Source="Nicolas_upshift_promotors" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 518372..518638 /gene="ydcT" /locus_tag="BSU_04890" /old_locus_tag="BSU04890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388370.1" /db_xref="EnsemblGenomes-Gn:BSU04890" /db_xref="EnsemblGenomes-Tr:CAB12296" /db_xref="SubtiList:BG12107" /db_xref="UniProtKB/Swiss-Prot:P96637" /translation="MFNINLLNQARLESDLDSLGCLDIAEELIEKMMEDVFYSDVAQR IIVQTLAVINNANAKLQATFNILEDEDMETDERSVEFEGISYYE*" gene 518372..518638 /gene="ydcT" /locus_tag="BSU_04890" /old_locus_tag="BSU04890" CDS 518655..518963 /gene="yddA" /locus_tag="BSU_04900" /old_locus_tag="BSU04900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388371.1" /db_xref="EnsemblGenomes-Gn:BSU04900" /db_xref="EnsemblGenomes-Tr:CAB12297" /db_xref="SubtiList:BG12108" /db_xref="UniProtKB/Swiss-Prot:P96638" /translation="MSAVDKRFKSLGFNVGIPSLVFVRSLSRDCMLVVEGERVKGFAE YRYTFYKTRYLPDGRMTSLKVYMENQSIKRVLHRVASFLSFLERTKQIEQKECEKVAQ *" gene 518655..518963 /gene="yddA" /locus_tag="BSU_04900" /old_locus_tag="BSU04900" CDS 518953..520017 /gene="conB" /locus_tag="BSU_04910" /old_locus_tag="BSU04910" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery VirB8" /protein_id="NP_388372.1" /db_xref="EnsemblGenomes-Gn:BSU04910" /db_xref="EnsemblGenomes-Tr:CAB12298" /db_xref="GOA:O31491" /db_xref="InterPro:IPR024735" /db_xref="InterPro:IPR035628" /db_xref="SubtiList:BG12109" /db_xref="UniProtKB/Swiss-Prot:O31491" /translation="MLNKEIGSDKKEESFFRSAFQKLKRIERPEKDKQKVPRDRSKLI AVTLWSCVGSLLFICLLAVLLSINTRSQLNDMKDETNKPTNDDKQKISVTAAENFLSG FINEYMNVKNDQESIEKRMQSLESYMVKQEDNHFEDEERFNVDGLKGDRELKGYSLYN VKEGDKNSLFQYKVTYENLYPVEKEVEKEVKDGKKKKKVKEKVKTNEKYEKQMLLNIP VTNKGDSFAVSAVPYFTQIYDLKGDIAFKGKEETRDEYAGEKKESIESFLQNFFEKYA SEKKEEMVYMMKKPEALEGNLLFGEVQSVKIFETKKGFEVFCAVRFKEKENDIPVNEK FSLEITENSGQFYVNKLKHQ*" gene 518953..520017 /gene="conB" /locus_tag="BSU_04910" /old_locus_tag="BSU04910" misc_feature 519491..519498 /Source="Nicolas_upshift_promotors" /id="U386" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.454545454545455" /xcortree=1489 /SigmaFactorBS="tgaaagaaggtgataaaaacagcctttttcaatataaggtca catatgaaaatctatACCCTGTAgaaaaggaagttgaaaaagaagttaaagacggaaa g" /listShort="yddC, yddD, yddE, yddF, yddG, yddH, yddI" /listLong="yddJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 519494 /Source="Nicolas_upshifts" /id="U386" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.454545454545455" /xcortree=1489 /SigmaFactorBS="tgaaagaaggtgataaaaacagcctttttcaatataaggtca catatgaaaatctatACCCTGTAgaaaaggaagttgaaaaagaagttaaagacggaaa g" /listShort="yddC, yddD, yddE, yddF, yddG, yddH, yddI" /listLong="yddJ" downshifts 519582 /Source="Nicolas_upshifts" /id="D233" /incds=1 /nref=1 /ntot=15 /MaxReadThrough="6.32422" /MaxDrop="3.45679" /score="-2.67923628" /energy="-7.8" /TU="U383,U386" /idTUdmin="U382" /TUdmin=2662 /isTUend="FALSE" CDS 520029..520277 /gene="conC" /locus_tag="BSU_04920" /old_locus_tag="BSU04920" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery" /protein_id="NP_388373.1" /db_xref="EnsemblGenomes-Gn:BSU04920" /db_xref="EnsemblGenomes-Tr:CAB12299" /db_xref="GOA:P96640" /db_xref="SubtiList:BG12110" /db_xref="UniProtKB/Swiss-Prot:P96640" /translation="MDFMNFFILGADLPTLGGVKGWASDVVIQFITIVVMFIAAKNLM KLKMGGIIFVCCIGSAVTWVIKHWSEFSGWINALMEKL*" gene 520029..520277 /gene="conC" /locus_tag="BSU_04920" /old_locus_tag="BSU04920" CDS 520290..520814 /gene="conD" /locus_tag="BSU_04930" /old_locus_tag="BSU04930" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery" /protein_id="NP_388374.1" /db_xref="EnsemblGenomes-Gn:BSU04930" /db_xref="EnsemblGenomes-Tr:CAB12300" /db_xref="GOA:P96641" /db_xref="InterPro:IPR025608" /db_xref="SubtiList:BG12111" /db_xref="UniProtKB/Swiss-Prot:P96641" /translation="MGRLVFNYRKAMREPKKIQQLTENYSLPFAVELIPAINYFIFVG LCFGFWYGVRMIFPHAFDNSYVIVIFGIPFFLTMLVTKIKPEGKNIYIYFFDFAKYYF FIKLPQKKYCNDRKIDLSNEKQIEFRKLVKVVDYSNETKNAYEGNTQEFAVNKNGRRV GVLPNKKQFDSYAK*" gene 520290..520814 /gene="conD" /locus_tag="BSU_04930" /old_locus_tag="BSU04930" CDS 520702..523197 /gene="conE" /locus_tag="BSU_04940" /old_locus_tag="BSU04940" /experiment="publication(s) with functional evidences, PMID:19734305, 19943900, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19734305, 19943900, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: VirB4-like ATPase" /protein_id="NP_388375.3" /db_xref="EnsemblGenomes-Gn:BSU04940" /db_xref="EnsemblGenomes-Tr:CAB12301" /db_xref="GOA:P96642" /db_xref="InterPro:IPR016628" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12112" /db_xref="UniProtKB/Swiss-Prot:P96642" /translation="MRLKTPMKAIHKNLLLTRTGDVWAYYRIKSNSIPMQNKEKVESY KKKWQHLFEEITSYEDFHLMMYPSEYELEKRFKDLETDIAADAMDVARYYNEETVRLL EQRLGRLTKYDFILGVKLKSSLVNISVELKDNILSFFNTATDTVVKMLGWEQNVSTSF FEKYEEVEETLANIMASVRGERLSETEMTYINRYHFVRGLKHQTNEESEIKDVRSITN TIIDPTDPSVLHLHSDQDEGYSAFVVIDEFLHNMSESDLFYEAQSLPFPVEVQMKIQT ESKSITKPALNLKRQQLKEEQKEQQSTGDRSDVSTVTSATMIRHLQDEIKKEDVHVMN WLSVIVVHGKTKKECVGKATIVKRHLKGAGITCRLPVADQLNLFYKMLPGEKLDITDK NWIQKTTQDGVAESLFAVNSDIGSKIGFFLGWVDRFQEHTDLESAIMSSRDFVLFHPF LANQQLKGSKTRSPHCLITGDTGNGKSYLAKLIFNYISMLNIKSLYIDPKKEMRKWIQ RVLNDEYIRENFPLYIAHLEKYNYITLDHENTHNWGALDPISFLPPMKAKELVQVIFE QVYDFKGKDDINTAFLRATSEVIDAKQKGEQVGSLDIIRKMQSHPEEAVQKAGDYLNE VVSDSILKLCIHDGSNPALSLEKRITILEVENMDLPDHAERLENYTISQLKSSAVMFA LGKFCELFGMNQDEQTVEFIDEAWIFTTSQQGKKVERQMRRIGRSYNNAEYFISQSTK DALKEEDSGNFGVAFAFDEPNEREEVLKWMNMEVTKDNKKMMESMFQGQCLFKDYYGR TSKISIECLFEEWQGALKTVEKKAVAYAEEKYL*" gene 520702..523197 /gene="conE" /locus_tag="BSU_04940" /old_locus_tag="BSU04940" CDS 523216..523542 /gene="yddF" /locus_tag="BSU_04950" /old_locus_tag="BSU04950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19943900, 22505685, 26013486; Producttype h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388376.1" /db_xref="EnsemblGenomes-Gn:BSU04950" /db_xref="EnsemblGenomes-Tr:CAB12302" /db_xref="InterPro:IPR015055" /db_xref="SubtiList:BG12113" /db_xref="UniProtKB/Swiss-Prot:P96643" /translation="MEIAFLNSLVVTSPGFYKAEKITLDEVKQWLKHYDGRYKSFIGH KSTAQFLQKLLGIRIEQNRKTFRHMKYQKAICFSLYERYPENVLLTQRDLEKARYQFY LLTRLD*" gene 523216..523542 /gene="yddF" /locus_tag="BSU_04950" /old_locus_tag="BSU04950" CDS 523546..525993 /gene="conG" /locus_tag="BSU_04960" /old_locus_tag="BSU04960" /experiment="publication(s) with functional evidences, PMID:19943900, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19943900, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: VirB6 subunit of the conjugation machinery" /protein_id="NP_388377.1" /db_xref="EnsemblGenomes-Gn:BSU04960" /db_xref="EnsemblGenomes-Tr:CAB12303" /db_xref="GOA:P96644" /db_xref="InterPro:IPR000515" /db_xref="SubtiList:BG12114" /db_xref="UniProtKB/Swiss-Prot:P96644" /translation="MVVMKKKRILIVSAIVLLFLTVASAVTVFSADGDTTTQPKVEKA GGVELKVKRFPISRYQANNEASDDLIKGAFVGLTNVTFSFAGNIVRVVDTGMDILYNL QPIDEFANSITNVSKTVYKTLKKNFGEALFIFTCAYVVYLFCVRGSVKEAMRRSILFI CVMVIGGLWMSNAGYYMKVLNALSVEAQGKLLTAGNGLVGIVQDEGNFADSSAIEKGK EMEGTVAVMRNLYFDIALMKPFLIVNFDETSEKKINEEDTDKGGLNRIDKLLSYKLSE DGEKDKKDYIKETEIDDYKNESMTSGNVFNQLGESFIAVVASIVIGIPFLALAFFNFL LQVVALVIVFFVPFAFILAYVPQLAYSGFVTLGRLGSVYLLKAMLGVIVLFVYVTCFI VDKLIPPNGFGMYLLNVAVLASILWIGFHKRDAIIKFVTAGKVVSVDNNMMENMRQNI VQPAWEQAKKIGGVWGNGGGVFTDFTKHFGGRKDGSNADGVTGAPSGGGNSPSGTAMG YDNTHAISRTPQKETANGIANHNSRSLKRNPQTLSKEQEKQKQKEAFANAKENKQQSH LARLRKDGINSPMLKDALNEGNEDLSKRAPILQDKKDESARTDQKEYVEQLLKQPNNQ QQTDDASLQHEEESTSNRAPVLQENEKDTERTDQKAYIYDEQNQNLETDQQQDFEVQK DDSVSNSEPVAQEKTAEIKRSDQKVMMNQPEPQLGFESPQSTKVENQPIANNERKIRP SEPAKVHSDGIRVDEKQAVAPAENKTVSREKQPSSQTIKRTEQSVNSFDQVSLNEIAR RSSSKVEDRLRRDERTR*" gene 523546..525993 /gene="conG" /locus_tag="BSU_04960" /old_locus_tag="BSU04960" CDS 525990..526979 /gene="cwlT" /locus_tag="BSU_04970" /old_locus_tag="BSU04970" /experiment="publication(s) with functional evidences, PMID:18305117, 22505685, 24532767, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18305117, 22505685, 24532767, 26013486; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: two-domain autolysin withN-acetylmuramidase and DL-endopeptidase activity VirB1" /protein_id="NP_388378.1" /db_xref="EnsemblGenomes-Gn:BSU04970" /db_xref="EnsemblGenomes-Tr:CAB12304" /db_xref="GOA:P96645" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG12115" /db_xref="UniProtKB/Swiss-Prot:P96645" /translation="MISKKVVLPLVFSAPFIFFFVLCIVVVMTISRENQVGDDFIGGG DGEYETVGIAPEVERFRAVFEKYARQEGVFDQVNIIMALTMQESGGRSLDIMQSSESI GLPPNSITDPERSIEVGIKHFKKVFKQAGGDVRLTLQAYNFGSGFIDYVKKNGGKYTK KLALDFSRLQAFKMGWKSYGDPSYVDHVMRYVKGSDKNVKPVKGSMDFYETVMKEALK YEGQPYAWGGSNPETGFDCSGLVQWSFAKAGITLPRTAQEQHGATKKISEKEATAGDL VFFGGTYEGKAITHVGIYVGNGRMFNSNDSGIQYSDLKSGYWRDHLVSFGRIK*" gene 525990..526979 /gene="cwlT" /locus_tag="BSU_04970" /old_locus_tag="BSU04970" CDS 526994..527500 /gene="yddI" /locus_tag="BSU_04980" /old_locus_tag="BSU04980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388379.1" /db_xref="EnsemblGenomes-Gn:BSU04980" /db_xref="EnsemblGenomes-Tr:CAB12305" /db_xref="GOA:P96646" /db_xref="SubtiList:BG12116" /db_xref="UniProtKB/Swiss-Prot:P96646" /translation="MKTHIAWASACLLLVMLTGFFTIGQQTYKIEKLKDKNEVLSEKI KELNHIESTSSASENKAFFEAFFNYSDIDIRYETVKKHTTGKGFDYAFPSRSDQKHTV SVQSELLSLESYSKPLDESHELFLNIVEVATTANSVTTNQVLIVQTTMKKEKDGWLVD NVQVKGNG*" gene 526994..527500 /gene="yddI" /locus_tag="BSU_04980" /old_locus_tag="BSU04980" promotor_-35 527503..527509 /Source="Nicolas_upshift_promotors" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 527523..527542 /Source="Nicolas_upshift_promotors" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 527532 /Source="Nicolas_upshifts" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" CDS 527563..527943 /gene="yddJ" /locus_tag="BSU_04990" /old_locus_tag="BSU04990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: putative lipoprotein of unknown function" /protein_id="NP_388380.1" /db_xref="EnsemblGenomes-Gn:BSU04990" /db_xref="EnsemblGenomes-Tr:CAB12306" /db_xref="InterPro:IPR028075" /db_xref="SubtiList:BG12117" /db_xref="UniProtKB/Swiss-Prot:P96647" /translation="MKNLFIFLSLMMMFVLTACGGSKYDDAIDDVISQYKEHKGNDTE INIKRENAIVRVYEGGKYIQFAFYMPDNSSRELTTFKYYEKFGDKYEKMTDMPGNGEN DRLGLSKKTPDYEEVKGEETELEE*" gene 527563..527943 /gene="yddJ" /locus_tag="BSU_04990" /old_locus_tag="BSU04990" downshifts 527920 /Source="Nicolas_upshifts" /id="D234" /incds=0 /nref=167 /ntot=245 /MaxReadThrough="2.07932" /MaxDrop="5.51482" /score="8.08816145" /energy="-14.7" /TU="NA" /idTUdmin="U383" /TUdmin=0 /isTUend="TRUE" downshifts complement(527996) /Source="Nicolas_upshifts" /id="D235" /incds=0 /nref=51 /ntot=228 /MaxReadThrough="3.21157" /MaxDrop="4.80215" /score="-2.66780619" /energy="-18.7" /TU="U388" /idTUdmin="U388" /TUdmin="-110" /isTUend="FALSE" S_feature complement(528019..528133) /Source="Nicolas_S_feature" /locus_tag="new_546051_546165_c" /HighExp="LPhT, Lbtran, Mt0, HiTm, Lbexp, M40t45, M0t45, HPh, dia0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S173" downshifts complement(528062) /Source="Nicolas_upshifts" /id="D236" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="5.69722" /MaxDrop="4.64006" /score="-2.66780619" /energy="-18.7" /TU="U388" /idTUdmin="U388" /TUdmin="-176" /isTUend="FALSE" CDS complement(528134..528934) /gene="yddK" /locus_tag="BSU_05000" /old_locus_tag="BSU05000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388381.1" /db_xref="EnsemblGenomes-Gn:BSU05000" /db_xref="EnsemblGenomes-Tr:CAB12307" /db_xref="GOA:P96648" /db_xref="InterPro:IPR000157" /db_xref="InterPro:IPR035897" /db_xref="SubtiList:BG12118" /db_xref="UniProtKB/Swiss-Prot:P96648" /translation="MDTLKKLKFEANGIIGVLLDYSREPVLTNIIDQFRTSLESNDIE LIRYSLEQLKTWYARNRNEIYKNEFVFNEFEHHETENKIKKFLDELPVVDETEKSSIT HFSSDQNRELEKKIFISHSSKDKIVCNAFVELLEDIGVSSEDIIYTSSPYHGIPGDED IFEYLKKHLFKGAYVFYMLSDNYYDSVYCLNEMGATWVNSNNCSTFILPGFKGEIKGV IDKNKKAFSLEEPIDLFNLKEKILRMYDLTLEDKKWERIKAKFNTKLK*" gene complement(528134..528934) /gene="yddK" /locus_tag="BSU_05000" /old_locus_tag="BSU05000" promotor_-10 complement(528979..528998) /Source="Nicolas_upshift_promotors" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(528997) /Source="Nicolas_upshifts" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" promotor_-35 complement(529014..529017) /Source="Nicolas_upshift_promotors" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" /label="promotor_-35" CDS 529274..530449 /gene="rapI" /locus_tag="BSU_05010" /old_locus_tag="BSU05010" /EC_number="3.1.-.-" /experiment="publication(s) with functional evidences, PMID:16105942, 22505685, 23526881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16105942, 22505685, 23526881; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: response regulator aspartate phosphatase" /protein_id="NP_388382.1" /db_xref="EnsemblGenomes-Gn:BSU05010" /db_xref="EnsemblGenomes-Tr:CAB12308" /db_xref="GOA:P96649" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4I1A" /db_xref="SubtiList:BG12119" /db_xref="UniProtKB/Swiss-Prot:P96649" /translation="MRGVFLDKDKIPYDLVTKKLNEWYTSIKNDQVEQAEIIKTEVEK ELLNMEENQDALLYYQLLEFRHEIMLSYMKSKEIEDLNNAYETIKEIEKQGQLTGMLE YYFYFFKGMYEFRRKELISAISAYRIAESKLSEVEDEIEKAEFFFKVSYVYYYMKQTY FSMNYANRALKIFREYEEYAVQTVRCQFIVAGNLIDSLEYERALEQFLKSLEISKESN IEHLIAMSHMNIGICYDELKEYKKASQHLILALEIFEKSKHSFLTKTLFTLTYVEAKQ QNYNVALIYFRKGRFIADKSDDKEYSAKFKILEGLFFSDGETQLIKNAFSYLASRKMF ADVENFSIEVADYFHEQGNLMLSNEYYRMSIEARRKIKKGEIIDENQPDSIGSSDFK* " gene 529274..530449 /gene="rapI" /locus_tag="BSU_05010" /old_locus_tag="BSU05010" promotor_-35 530129..530136 /Source="Nicolas_upshift_promotors" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 530150..530168 /Source="Nicolas_upshift_promotors" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 530160 /Source="Nicolas_upshifts" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" promotor_-35 530357..530363 /Source="Nicolas_upshift_promotors" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530362 /Source="Nicolas_upshifts" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" promotor_-10 530378..530389 /Source="Nicolas_upshift_promotors" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 530406..530525 /gene="phrI" /locus_tag="BSU_05020" /old_locus_tag="BSU05020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200, 21908671, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 21908671, 22505685; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: secreted regulator of theactivity of phosphatase RapI" /protein_id="NP_388383.1" /db_xref="EnsemblGenomes-Gn:BSU05020" /db_xref="EnsemblGenomes-Tr:CAB12309" /db_xref="SubtiList:BG12645" /db_xref="UniProtKB/Swiss-Prot:O31492" /translation="MKISRILLAAVILSSVFSITYLQSDHNTEIKVAADRVGA*" gene 530406..530525 /gene="phrI" /locus_tag="BSU_05020" /old_locus_tag="BSU05020" downshifts 530523 /Source="Nicolas_upshifts" /id="D237" /incds=0 /nref=46 /ntot=227 /MaxReadThrough="4.14733" /MaxDrop="5.8523" /score="15.7846721" /energy="-10.4" /TU="U389" /idTUdmin="U390" /TUdmin="-15" /isTUend="TRUE" CDS 530678..531619 /gene="yddM" /locus_tag="BSU_05030" /old_locus_tag="BSU05030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: putative helicase" /protein_id="NP_388384.1" /db_xref="EnsemblGenomes-Gn:BSU05030" /db_xref="EnsemblGenomes-Tr:CAB12310" /db_xref="GOA:P96650" /db_xref="SubtiList:BG12120" /db_xref="UniProtKB/Swiss-Prot:P96650" /translation="MGENMFKKEKVTEYIWTILIPTIITFIISWVGSYYNGTSTVSIG QPTKVSGQYITPINISPYHDIKELRITFPQKLDVKQISSNEPINVKSDKNNIGVESNS TFEIAKIVENNSVQLLITTQKKLNDKEIRIDKNGNNISVNYESQIVNPAKKQLINLII TSSIYFIMLNILALIMNKRWDKYYAKMKNEIKEFEDNAKDLDKKSKKKSEELSELRKT LNQAFEETDRIKYHEKKKQILLLAKLNDYKKELTFWRNTIRKVLYELPDGDKKADKLI GTVTSSLKTYGTVEKNEHDYESLKVAAALLNDSDKRS*" gene 530678..531619 /gene="yddM" /locus_tag="BSU_05030" /old_locus_tag="BSU05030" S_feature 531620..531878 /Source="Nicolas_S_feature" /locus_tag="new_549652_549910" /HighExp="HPh, S1, Gly, LoTm, LPh, MG 120, GM-0.1, aero, S2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80510899999999996" /TUshortSig="SigD" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S174" S_feature complement(531891..532207) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S175" downshifts 531920 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" downshifts complement(531952) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" CDS complement(532208..533227) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" gene complement(532208..533227) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" promotor_-10 complement(532903..532922) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532916) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" promotor_-35 complement(532937..532944) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 533016..533020 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 533037..533056 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 533041 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" S_feature 533042..533486 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 533487..533897 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" gene 533487..533897 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" S_feature 533898..533967 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 533924 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" CDS complement(534020..534469) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" gene complement(534020..534469) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" CDS 534584..535126 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" gene 534584..535126 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" promotor_-35 535599..535603 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535620..535639 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 535629 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" CDS 535679..536443 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" gene 535679..536443 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" CDS 536637..537947 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" gene 536637..537947 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" S_feature 537970..538529 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 538530..538706 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" gene 538530..538706 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" CDS 538731..539417 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" gene 538731..539417 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" promotor_-35 539759..539763 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 539778..539797 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 539786 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" CDS 539841..540026 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" gene 539841..540026 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" downshifts 540025 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" CDS 540376..540969 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" gene 540376..540969 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" promotor_-35 541082..541089 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 541103..541122 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 541114..541231 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 541114 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" downshifts complement(541149) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" CDS 541232..541432 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" gene 541232..541432 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" S_feature complement(541330..542118) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 541335 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" downshifts 541436 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" misc_RNA complement(541500..541578) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene complement(541500..541578) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" CDS complement(542119..542580) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" gene complement(542119..542580) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" S_feature 542589..543134 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(542632) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" promotor_-10 complement(542639..542658) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(542674..542681) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 543101 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" CDS complement(543148..543384) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" gene complement(543148..543384) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" CDS complement(543482..544357) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" gene complement(543482..544357) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" CDS 544470..545429 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" gene 544470..545429 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" upshifts complement(544491) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" misc_feature complement(544495..544514) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(545582..546454) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" gene complement(545582..546454) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" promotor_-10 complement(546547..546552) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(546554..546555) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546559) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 546628..546634 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 546642 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" promotor_-10 546648..546667 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 546681..548069 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" gene 546681..548069 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" downshifts 548045 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" CDS 548179..549471 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" gene 548179..549471 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" promotor_-35 549480..549486 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 549501..549520 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 549508 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" S_feature 549519..549629 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 549630..550076 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" gene 549630..550076 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" downshifts 550105 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" promotor_-35 550156..550163 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 550178..550197 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 550179 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" CDS 550313..550906 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" gene 550313..550906 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" downshifts 550949 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" downshifts complement(551025) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" promotor_-35 551038..551045 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 551059 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 551060..551079 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(551258..551917) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" gene complement(551258..551917) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" promotor_-10 complement(551966..551985) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(551973) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" promotor_-35 complement(551997..552002) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(552339..553202) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" gene complement(552339..553202) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" promotor_-35 553245..553251 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 553266..553285 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(553267..553286) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 553281 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(553291) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(553301..553308) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 553357..554748 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" gene 553357..554748 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" promotor_-35 554876..554883 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 554894..554913 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 554908 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" CDS 554942..555367 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" gene 554942..555367 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" S_feature 555368..556622 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(555420..555992) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" gene complement(555420..555992) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" downshifts complement(555425) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" S_feature complement(555993..556073) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(556074..556403) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" gene complement(556074..556403) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" misc_feature complement(556420..556439) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(556437) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" misc_feature 556611..556630 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 556624 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" CDS 556658..557530 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" gene 556658..557530 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" downshifts 557417 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" downshifts 557615 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" CDS complement(557680..558066) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" gene complement(557680..558066) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" downshifts complement(557692) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" S_feature complement(558067..558131) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 558119..558126 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(558120..558139) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(558133) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" promotor_-10 558140..558159 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 558143 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" promotor_-35 complement(558154..558161) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 558177..558770 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" gene 558177..558770 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" CDS complement(558914..560101) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" gene complement(558914..560101) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" promotor_-35 560237..560241 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 560255 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" promotor_-10 560256..560275 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 560305..560901 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" gene 560305..560901 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" CDS 561015..561200 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" gene 561015..561200 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" downshifts 561179 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" promotor_-35 561312..561315 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 561322..561508 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 561322 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" promotor_-10 561330..561349 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 561509..561844 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" gene 561509..561844 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" CDS 561857..563164 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" gene 561857..563164 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" CDS 563196..563300 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" gene 563196..563300 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo CDS 563309..563422 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" gene 563309..563422 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo promotor_-35 563608..563616 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 563627..563645 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 563644 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 563662..564447 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" gene 563662..564447 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" downshifts 563709 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" downshifts 564457 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" CDS complement(564504..565424) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" gene complement(564504..565424) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" CDS 565557..567005 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" gene 565557..567005 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" CDS complement(567123..567746) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" gene complement(567123..567746) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" promotor_-10 complement(567770..567789) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 567778..567785 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(567789) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" promotor_-10 567800..567819 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567802 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" promotor_-35 complement(567804..567810) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 567836..568516 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" gene 567836..568516 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" downshifts 568549 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" CDS complement(568596..569039) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" gene complement(568596..569039) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" downshifts complement(568601) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(569062..569081) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569086) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" promotor_-35 complement(569095..569102) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(569125..569304) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" gene complement(569125..569304) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" CDS complement(569301..569444) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" gene complement(569301..569444) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" promotor_-35 569395..569397 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569413..569432 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569429 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 569712..570935 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" gene 569712..570935 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" CDS 570928..571569 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" gene 570928..571569 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" downshifts 571563 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" promotor_-10 complement(571596..571615) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(571617) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(571629..571636) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 571677..571682 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 571685..573859 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" gene 571685..573859 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" upshifts 571695 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" promotor_-10 571697..571715 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(572761..572779) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(572761) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(573863..574270) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 573880..573884 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 573894 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 573897..573916 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(573908) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" CDS complement(574271..575173) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" gene complement(574271..575173) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" S_feature complement(575174..575269) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(575249..575268) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(575269) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" promotor_-35 complement(575282..575289) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(575375..576064) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" gene complement(575375..576064) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" CDS complement(576154..576966) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" gene complement(576154..576966) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" promotor_-10 complement(576995..577014) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(577008) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" promotor_-35 complement(577030..577037) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(577077..577970) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" gene complement(577077..577970) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" downshifts complement(577097) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" S_feature complement(577971..578063) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(578044..578063) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(578061) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" promotor_-35 complement(578079..578086) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 578252..578259 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 578274..578293 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 578280 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" CDS 578446..579066 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" gene 578446..579066 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" promotor_-35 578790..578796 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 578801 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" promotor_-10 578810..578828 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 579082..580020 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" gene 579082..580020 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" promotor_-35 580008..580011 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 580026..580045 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 580033..580121 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 580033 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" CDS 580122..580511 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" gene 580122..580511 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" downshifts 580502 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" misc_feature 580625..580644 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 580627..580696 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 580627 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" CDS 580697..581035 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" gene 580697..581035 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" downshifts 581023 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" CDS complement(581075..581311) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" gene complement(581075..581311) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" downshifts complement(581099) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" promotor_-35 581123..581129 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 581144..581155 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 581155 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(581312..581473) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(581477..581842) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(581517) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" CDS complement(581843..582073) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" gene complement(581843..582073) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" downshifts 582057 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" promotor_-10 complement(582094..582113) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582111) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" S_feature complement(582113..582196) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(582127..582136) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(582197..582874) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" gene complement(582197..582874) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" promotor_-10 complement(582845..582856) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582859) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" promotor_-35 complement(582871..582877) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(582875..583708) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 582890..582895 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582910..582921 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 582915 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" CDS 582987..583694 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" gene 582987..583694 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" CDS complement(583709..584140) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" gene complement(583709..584140) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" CDS complement(584153..584395) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" gene complement(584153..584395) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" CDS complement(584409..584681) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" gene complement(584409..584681) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" promotor_-10 complement(584703..584722) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(584707) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" promotor_-35 complement(584736..584745) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 584900..584907 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584923..584942 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584931 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" CDS 584980..585567 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" gene 584980..585567 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" CDS 585564..585908 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" gene 585564..585908 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" S_feature 585909..586070 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 586071..586544 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" gene 586071..586544 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" S_feature 586545..587237 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(586687) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" CDS complement(586704..588347) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" gene complement(586704..588347) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" S_feature complement(588382..588579) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 588396..588398 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 588415..588433 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 588419 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(588425) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" downshifts 588545 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(588571..588590) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(588583) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" promotor_-35 complement(588603..588610) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(588666) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" CDS complement(588667..590043) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" gene complement(588667..590043) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" misc_feature complement(590093..590112) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(590108) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" CDS complement(590214..590732) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" gene complement(590214..590732) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" downshifts complement(590228) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(590758..590777) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(590777) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" promotor_-35 complement(590793..590796) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 590814..590821 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 590836..590855 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 590854 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" CDS 590901..591359 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388445.1" /db_xref="EnsemblGenomes-Gn:BSU05640" /db_xref="EnsemblGenomes-Tr:CAB12371" /db_xref="GOA:P96705" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12174" /db_xref="UniProtKB/Swiss-Prot:P96705" /translation="MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLL KILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITP SGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE*" gene 590901..591359 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" CDS 591356..594013 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388446.1" /db_xref="EnsemblGenomes-Gn:BSU05650" /db_xref="EnsemblGenomes-Tr:CAB12372" /db_xref="GOA:P96706" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12175" /db_xref="UniProtKB/Swiss-Prot:P96706" /translation="MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPAD AVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPL SAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQ DFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVY NVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTL FISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPS KKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYK SIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTI TQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNG GSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQAN QQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTG IFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEV DGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYM IASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEE VHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGL VILPLFIPAIIATFGEGNWWPFGRKKGKE*" gene 591356..594013 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" downshifts 594134 /Source="Nicolas_upshifts" /id="D272" /incds=0 /nref=3 /ntot=27 /MaxReadThrough="0.245049999999999" /MaxDrop="4.45167" /score="13.780898" /energy="-13.9" /TU="NA" /idTUdmin="U439" /TUdmin=22 /isTUend="TRUE" CDS complement(594159..594788) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26415543; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase of unidentified specificity (reduces 5-(aziridin-1-yl)-2,4-dinitrobenzamide prodrug)" /protein_id="NP_388447.1" /db_xref="EnsemblGenomes-Gn:BSU05660" /db_xref="EnsemblGenomes-Tr:CAB12385" /db_xref="GOA:P96707" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12176" /db_xref="UniProtKB/Swiss-Prot:P96707" /translation="MIKTNDFMEIMKGRRSIRNYDPAVKISKEEMTEILEEATTAPSS VNAQPWRFLVIDSPEGKEKLAPLASFNQTQVTTSSAVIAVFADMNNADYLEEIYSKAV ELGYMPQEVKDRQIAALTAHFEKLPAQVNRETILIDGGLVSMQLMLTARAHGYDTNPI GGYDKENIAETFGLDKERYVPVMLLSIGKAADEGYASYRLPIDTIAEWK*" gene complement(594159..594788) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" downshifts complement(594163) /Source="Nicolas_upshifts" /id="D273" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="2.66406" /MaxDrop="6.06581" /score="21.7451043" /energy="-16.6" /TU="NA" /idTUdmin="U440" /TUdmin=3 /isTUend="TRUE" CDS complement(594804..595298) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388448.1" /db_xref="EnsemblGenomes-Gn:BSU05670" /db_xref="EnsemblGenomes-Tr:CAB12386" /db_xref="GOA:P96708" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12177" /db_xref="UniProtKB/Swiss-Prot:P96708" /translation="MTCQSLIYQLIVLTGKKGWVLASFCSEEAEILYQLQGVNKVIGV KFEACTGISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRR KPEDNRITLVRLTDQGRERIESSKKEKERFMKEMLANVSAEERRLLIDVLARMRNNIN NIEA*" gene complement(594804..595298) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" promotor_-10 complement(595290..595309) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(595305) /Source="Nicolas_upshifts" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" promotor_-35 complement(595325..595330) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 595496..595498 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 595514..595533 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 595520..595608 /Source="Nicolas_S_feature" /locus_tag="new_613552_613640" /HighExp="H2O2, G180, G135, Diami, Paraq, Oxctl, G150, LBGexp, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S199" upshifts 595520 /Source="Nicolas_upshifts" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" CDS 595609..596817 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388449.1" /db_xref="EnsemblGenomes-Gn:BSU05680" /db_xref="EnsemblGenomes-Tr:CAB12387" /db_xref="GOA:P96709" /db_xref="InterPro:IPR004812" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12178" /db_xref="UniProtKB/Swiss-Prot:P96709" /translation="MLHNPTGKERLALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSA SASLVQLSLTACLVGLTIGQLIVGPVSDAQGRRKPLLICIFLFALSSLFCALSPNITT LVAARFLQGFTASAGLVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL LLPFATWHTIFHVLMIIGFLLVLLIALRLKETLPLEKRIPSSIGTSVKTMGSLLKDRS FMGYALTVGFIHGGSFAYVSGTPFVYQDIYGVSPQVFSILFGINGLAIISGSFIIGRF GGIIHEKSLLRIAVITAMIATAVLLTMTMIHGPLATLVISIFIYMITIGMVLTSTFTL AMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINETTAVPMGAIMFVTAVIGSLAFFG LTKERVGQNS*" gene 595609..596817 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" downshifts 596796 /Source="Nicolas_upshifts" /id="D274" /incds=0 /nref=23 /ntot=112 /MaxReadThrough="0.507390000000001" /MaxDrop="3.27202" /score="25.806679" /energy="-7.5" /TU="NA" /idTUdmin="U441" /TUdmin=0 /isTUend="TRUE" CDS complement(596853..597590) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388450.2" /db_xref="EnsemblGenomes-Gn:BSU05690" /db_xref="EnsemblGenomes-Tr:CAB12388" /db_xref="GOA:O05493" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG12179" /db_xref="UniProtKB/Swiss-Prot:O05493" /translation="MLIILVMFLLGIILGFIGAGGAGFVIALLTLLFHIPIHTALGTS LAGMAFTSLSGAYSHYREGNIQMKIGLIVGGFAAVGSFFGAKLTSFIPADLLHYLTAG MLFLSAILILIRLFILKEKAQVNQSTLSTYTRAVILGIAAGVLSGTFGIGSAPFIQIG LMIMLNLSIRHSVGTTMLVIIPLAVGGGIGYITEGFVDYVLLVKVLVGTMCGAYVGAK FTNLMPKVVLKSAIFLTPAIAGLLLLF*" gene complement(596853..597590) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" S_feature complement(597591..597729) /Source="Nicolas_S_feature" /locus_tag="new_615623_615761_c" /HighExp="T0.30H, T1.30H, T1.0H, T-0.40H, T2.0H, T0.0H, LBGstat, T2.30H, T-1.10H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.108111" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S200" promotor_-10 complement(597717..597736) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(597729) /Source="Nicolas_upshifts" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" promotor_-35 complement(597750..597757) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 597761..597768 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597782..597801 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 597786 /Source="Nicolas_upshifts" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" CDS 597839..598513 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388451.1" /db_xref="EnsemblGenomes-Gn:BSU05700" /db_xref="EnsemblGenomes-Tr:CAB12389" /db_xref="GOA:O05494" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12180" /db_xref="UniProtKB/Swiss-Prot:O05494" /translation="MDDFKLDKPTPYYLQFYNQLKKMIFNGTFKPGERINETQLAKSF GVSRSPIREAMRLLEKDGLLKADDRNGFSITSLTAKDVDEIYKIRIPLEQLAVELVID EADEEELTILEKQLEETEKAIHNGTEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVN DLIHFCRILNYTGDHRAETILREHRRIFEEVKKKNKEAAKQHVLAHFNHDCEHLKHVL EEGKEN*" gene 597839..598513 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" promotor_-35 598572..598577 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598593..598611 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598599 /Source="Nicolas_upshifts" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" CDS 598640..599902 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11011148, 12177332; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore cortex lytic enzyme" /protein_id="NP_388452.2" /db_xref="EnsemblGenomes-Gn:BSU05710" /db_xref="EnsemblGenomes-Tr:CAB12390" /db_xref="GOA:O05495" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:3CZ8" /db_xref="SubtiList:BG12181" /db_xref="UniProtKB/Swiss-Prot:O05495" /translation="MFIHIVGPGDSLFSIGRRYGASVDQIRGVNGLDETNIVPGQALL IPLYVYTVQPRDTLTAIAAKAFVPLERLRAANPGISPNALQAGAKITIPSISNYIAGT LSFYVLRNPDLDRELINDYAPYSSSISIFEYHIAPNGDIANQLNDAAAIETTWQRRVT PLATITNLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFEQVSAAD RDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMAYD WHHAGSEPGPVAPITEIRRTIEFTIAQVPSRKIIIGVPLYGYDWIIPYQPGTVASAIS NQNAIERAMRYQAPIQYSAEYQSPFFRYSDQQGRTHEVWFEDVRSMSRKMQIVREYRL QAIGAWQLTLGFTPGPWLLRKFFTIRKV*" gene 598640..599902 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" downshifts 599876 /Source="Nicolas_upshifts" /id="D275" /incds=0 /nref=33 /ntot=81 /MaxReadThrough="2.3134" /MaxDrop="5.20337" /score="15.7593331" /energy="-7.1" /TU="NA" /idTUdmin="U444" /TUdmin=0 /isTUend="TRUE" promotor_-35 599974..599981 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599995..600014 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 599999 /Source="Nicolas_upshifts" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" CDS 600063..601250 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388453.2" /db_xref="EnsemblGenomes-Gn:BSU05720" /db_xref="EnsemblGenomes-Tr:CAB12391" /db_xref="GOA:O05496" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG12182" /db_xref="UniProtKB/Swiss-Prot:O05496" /translation="MKTVLILNFPAEGHVNPTLGITKAFSDKGYDVHYISTEKYKKRL EAAGATVHLHRDLLRTTPIHVGSPNGILDFVKIHIKTSLDILQIVKDLSKSIQFDFVY YDKFGAGELVRDYLDIPGVSSSASFLFGEEHLKILPLHPESGAPLELDQECEDLLAKM KETYGVAPKNLVQFMNNKGELNVVYTSRYFQPESDRFGDECLFIGPSFPKRAEKTDFP IEQLKDEKVIYISMGTVLDHTEDFFNLCIDAFSGFNGKVVIAAGEKADLTKLKQAPEN FIIAPYVPQLEVLEQSDVFITHGGMNSVNEGIHFSVPLVVMPHDKDQPMVAQRLSELH AGYVISKDEVNAQILKQAVDEVLRNDQYTAGIKKINQSFKECMDMEEVMERIDELIRQ KNK*" gene 600063..601250 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" downshifts 601262 /Source="Nicolas_upshifts" /id="D276" /incds=0 /nref=17 /ntot=224 /MaxReadThrough="1.77672" /MaxDrop="5.25325" /score="-6.36206618" /energy="-12.6" /TU="NA" /idTUdmin="U445" /TUdmin=1 /isTUend="TRUE" CDS complement(601289..601999) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913081, 11557812; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative phosphate-starvation lipoprotein" /protein_id="NP_388454.1" /db_xref="EnsemblGenomes-Gn:BSU05730" /db_xref="EnsemblGenomes-Tr:CAB12392" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12183" /db_xref="UniProtKB/Swiss-Prot:O05497" /translation="MRRILSILVFAIMLAGCSSNASTEKQHAGGEKTVKAEPQSTSSQ KDSTDDYQPNSQVTDDRTLHKVGQTFSDDKGKAVLKDIKQVNKTYKIGDVELTVKEMK LIHLRPDYSMIDYFHELTHDEEFDFVKVFVDIKNTSTKKVNVAPIALMKTNTGETFDW NKDIYLEELNGELEGGAEKSGNLGFIVNASSGHAHDKAADAEKKTKEIKWIEITTSDV FDHNHKKISDAQKIKIKF*" gene complement(601289..601999) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" downshifts complement(601315) /Source="Nicolas_upshifts" /id="D277" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="4.05808" /MaxDrop="4.7318" /score="13.7192471" /energy="-12.6" /TU="NA" /idTUdmin="U446" /TUdmin=0 /isTUend="TRUE" CDS complement(602065..603453) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9335276, 10913081, 16030210, 16491025, 26382712, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9335276, 10913081, 16030210, 16491025, 26382712, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase III (promiscuous, heptaprenylglyceryl phosphate is a substrate)" /protein_id="NP_388455.2" /db_xref="EnsemblGenomes-Gn:BSU05740" /db_xref="EnsemblGenomes-Tr:CAB12393" /db_xref="GOA:P19405" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10697" /db_xref="UniProtKB/Swiss-Prot:P19405" /translation="MKKFPKKLLPIAVLSSIAFSSLASGSVPEASAQEKKKGNQDEIK NVIVLIGDGMGVSYTSAYRYLKDNKKTKVVEPTAFDQYLVGQQTTYPDDPEQNVTDSA AAATAMSAGIKTYNNAIAVDNDGSEAKTVLEAAKEKGKATGLVATSEITHATPASFGS HDHSRKNMNSIADDYFDEMVNGKHKIDVLLGGGKSNFDRKDRNLIKEFKKAGYSYVDD RKDMLKNKDSQVLGLFADGGLPKKIDRTKDIPSLKDMTNTAIKKLNKDKDGFFLMVEG SQIDWAGHDNDIVGAMSEMEDFEQAYKAAIDFAKKDKHTLVVATADHSTGGYSIGADG IYNWFSEPIKAAKRTPDFMAEKIADGADVEKTLKTYIDQKKLALTKAEIQSVEEAAKS KEVLDIDNAIENIFNKRSHTGWTTGGHTGEDVPVYAYGPSSETFAGQIDNTEIAKNVF KALQYNIKINDK*" gene complement(602065..603453) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" promotor_-10 complement(603510..603527) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(603511) /Source="Nicolas_upshifts" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" S_feature complement(603513..603581) /Source="Nicolas_S_feature" /locus_tag="new_621545_621613_c" /HighExp="S6, S4, S5, S3, S7, LoTm, S8, T5.0H, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S201" promotor_-35 complement(603534..603541) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(603571..603589) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(603589) /Source="Nicolas_upshifts" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" promotor_-35 complement(603605..603610) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 603658..603665 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 603679..603698 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 603681..603814 /Source="Nicolas_S_feature" /locus_tag="new_621713_621846" /HighExp="Diami, dia15, H2O2, Paraq, Oxctl, HPh, G180, G135, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S202" upshifts 603681 /Source="Nicolas_upshifts" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" CDS 603815..604186 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:20087498, 21744456, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20087498, 21744456, 25826316; Product type f: factor" /codon_start=1 /transl_table=11 /product="frataxin; iron/sulfur chaperone" /protein_id="NP_388456.1" /db_xref="EnsemblGenomes-Gn:BSU05750" /db_xref="EnsemblGenomes-Tr:CAB12394" /db_xref="GOA:Q797E6" /db_xref="InterPro:IPR014922" /db_xref="PDB:2OC6" /db_xref="SubtiList:BG12184" /db_xref="UniProtKB/Swiss-Prot:Q797E6" /translation="MDVFSEYLAGIADPFHRERTEEVLTWIKNKYPNLHTEIKWNQPM FTDHGTFIIGFSVSKKHLAVAPEKVTIAHVEDDIVKAGYDYTEQLIRIPWNGPVDYTL LEKMIEFNILDKADCSTFWRK*" gene 603815..604186 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" downshifts 604165 /Source="Nicolas_upshifts" /id="D278" /incds=0 /nref=9 /ntot=150 /MaxReadThrough="2.88587" /MaxDrop="3.59127" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U448" /TUdmin=0 /isTUend="TRUE" downshifts complement(604260) /Source="Nicolas_upshifts" /id="D279" /incds=0 /nref=9 /ntot=187 /MaxReadThrough="1.63268" /MaxDrop="2.98181" /score="0.51805655" /energy="-13" /TU="NA" /idTUdmin="U450" /TUdmin=2 /isTUend="TRUE" CDS complement(604261..604758) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388457.1" /db_xref="EnsemblGenomes-Gn:BSU05760" /db_xref="EnsemblGenomes-Tr:CAB12395" /db_xref="GOA:O05500" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG12185" /db_xref="UniProtKB/Swiss-Prot:O05500" /translation="MSSHYKYPLIFTAFLLIAFCLIFFSYHLIHHVRLEYPNWQGESK DQNWEAVFTKNEDAPNEYSGKLYWIGDTIEIDNTYLESLIVKKDDEVLLSSDTEIPMH DYAGGTFSDGSAKEKSVSFLERLDEHELEGHDITIEVKWKQGNHYSASQLTLNEKTLF DEKQQ*" gene complement(604261..604758) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" CDS complement(604776..605258) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388458.1" /db_xref="EnsemblGenomes-Gn:BSU05770" /db_xref="EnsemblGenomes-Tr:CAB12396" /db_xref="GOA:O05501" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12186" /db_xref="UniProtKB/Swiss-Prot:O05501" /translation="MMIIIPNNEIAKHMLTDFFAKHWGTPEMAISSGIFRCDELDGFA AVNESGEIIGCITYTIDGKDCEIISLDSMIENKGIGTALLQQVEEKAKHAHCQRIKLI TTNDNVNAIAFYQKRGYQFAAVFPNAVEKARRLKPEIPEVAENGILIRDEILFSKVID *" gene complement(604776..605258) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" promotor_-35 604931..604938 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 604952..604971 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 604956 /Source="Nicolas_upshifts" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(605287..605306) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(605297) /Source="Nicolas_upshifts" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" promotor_-35 complement(605321..605324) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 605341..606318 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_388459.1" /db_xref="EnsemblGenomes-Gn:BSU05780" /db_xref="EnsemblGenomes-Tr:CAB12397" /db_xref="GOA:O05502" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG12187" /db_xref="UniProtKB/Swiss-Prot:O05502" /translation="MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRK WNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENI FQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGH INLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARA LKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQ KKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ*" gene 605341..606318 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" downshifts 606298 /Source="Nicolas_upshifts" /id="D280" /incds=0 /nref=2 /ntot=92 /MaxReadThrough="2.31799" /MaxDrop="3.19063" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U451" /TUdmin="-770" /isTUend="FALSE" promotor_-35 606345..606351 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 606366..606384 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 606374 /Source="Nicolas_upshifts" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" promotor_-35 606410..606417 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 606430 /Source="Nicolas_upshifts" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" promotor_-10 606431..606450 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 606460..607077 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388460.1" /db_xref="EnsemblGenomes-Gn:BSU05790" /db_xref="EnsemblGenomes-Tr:CAB12398" /db_xref="InterPro:IPR011438" /db_xref="PDB:2KY9" /db_xref="PDB:4FIB" /db_xref="PDB:4MDW" /db_xref="SubtiList:BG12188" /db_xref="UniProtKB/Swiss-Prot:O05503" /translation="MSAGKSYRKKMKQRRMNMKISKYALGILMLSLVFVLSACGNNNS TKESTHDNHSDSSTHEEMDHSGSADVPEGLQESKNPKYKVGSQVIINTSHMKGMKGAE ATVTGAYDTTAYVVSYTPTNGGQRVDHHKWVIQEEIKDAGDKTLQPGDQVILEASHMK GMKGATAEIDSAEKTTVYMVDYTSTTSGEKVKNHKWVTEDELSAK*" gene 606460..607077 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" downshifts 607064 /Source="Nicolas_upshifts" /id="D281" /incds=0 /nref=62 /ntot=212 /MaxReadThrough="1.07295" /MaxDrop="7.27889" /score="30.3859931" /energy="-11.4" /TU="U452" /idTUdmin="U451" /TUdmin="-4" /isTUend="TRUE" CDS complement(607093..608259) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12923093, 15849754, 16850406, 17935948, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15849754, 16850406, 17935948, 25573585; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine efflux transporter" /protein_id="NP_388461.2" /db_xref="EnsemblGenomes-Gn:BSU05800" /db_xref="EnsemblGenomes-Tr:CAB12399" /db_xref="GOA:Q797E3" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12189" /db_xref="UniProtKB/Swiss-Prot:Q797E3" /translation="MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLI SVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAA MSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILF LGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTL YAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFA IIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQ VGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL*" gene complement(607093..608259) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" downshifts complement(607122) /Source="Nicolas_upshifts" /id="D282" /incds=0 /nref=40 /ntot=58 /MaxReadThrough="2.22188" /MaxDrop="4.89202" /score="36.362851" /energy="-12.4" /TU="NA" /idTUdmin="U453" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(608314..608414) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /product="adenine riboswitch" /experiment="publication(s) with functional evidences, PMID:14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585; Product type n: RNA" gene complement(608314..608414) /gene="aswA" /locus_tag="BSU_misc_RNA_8" downshifts complement(608355) /Source="Nicolas_upshifts" /id="D283" /incds=0 /nref=38 /ntot=127 /MaxReadThrough="5.85661" /MaxDrop="6.06248" /score="33.0784595" /energy="-19.4" /TU="U453" /idTUdmin="U453" /TUdmin="-1233" /isTUend="FALSE" promotor_-10 complement(608424..608443) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(608438) /Source="Nicolas_upshifts" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" promotor_-35 complement(608459..608463) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 608522..608529 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 608543..608562 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 608550 /Source="Nicolas_upshifts" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" CDS 608590..608901 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18177310; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIB" /protein_id="NP_388462.1" /db_xref="EnsemblGenomes-Gn:BSU05810" /db_xref="EnsemblGenomes-Tr:CAB12400" /db_xref="GOA:O05505" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG12190" /db_xref="UniProtKB/Swiss-Prot:O05505" /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKE DMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVN Q*" gene 608590..608901 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" CDS 608901..609233 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIA" /protein_id="NP_388463.2" /db_xref="EnsemblGenomes-Gn:BSU05820" /db_xref="EnsemblGenomes-Tr:CAB12401" /db_xref="GOA:O05506" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG12191" /db_xref="UniProtKB/Swiss-Prot:O05506" /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEA DALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEML DLFKTKNI*" gene 608901..609233 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" CDS 609252..610580 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18177310; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIC" /protein_id="NP_388464.1" /db_xref="EnsemblGenomes-Gn:BSU05830" /db_xref="EnsemblGenomes-Tr:CAB12402" /db_xref="GOA:O05507" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG12192" /db_xref="UniProtKB/Swiss-Prot:O05507" /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVV LTNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGG AIALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKN LTIKMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLV GLGSGIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHI ISKPFMEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGL PIVMNPIIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIM GGVMQLINLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM*" gene 609252..610580 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" CDS 610598..611995 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18177310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannoside-phospho-beta-d-glucosidase" /protein_id="NP_388465.1" /db_xref="EnsemblGenomes-Gn:BSU05840" /db_xref="EnsemblGenomes-Tr:CAB12403" /db_xref="GOA:O05508" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="SubtiList:BG12193" /db_xref="UniProtKB/Swiss-Prot:O05508" /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEK EPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAA DFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGG RVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQD GKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGF MPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRK MNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRI EFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVK KSGKWFKEVAEHSGF*" gene 610598..611995 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" S_feature 611996..612082 /Source="Nicolas_S_feature" /locus_tag="new_630028_630114" /HighExp="G150, T0.30H, T1.0H, M40t90, T1.30H, Mt0, M0t90, Lbexp, dia0, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S203" promotor_-35 612060..612067 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 612081..612100 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 612084 /Source="Nicolas_upshifts" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" CDS 612138..612851 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18177310; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388466.1" /db_xref="EnsemblGenomes-Gn:BSU05850" /db_xref="EnsemblGenomes-Tr:CAB12404" /db_xref="GOA:O05509" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12194" /db_xref="UniProtKB/Swiss-Prot:O05509" /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMK RALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQF EVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDS IYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEY SFSRHRHDKFVVTSVNIRR*" gene 612138..612851 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" CDS 612880..613779 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /EC_number="2.7.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15018644, 18177310, 21185308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15018644, 18177310, 21185308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ROK fructokinase; glucomannan utilization protein E" /protein_id="NP_388467.1" /db_xref="EnsemblGenomes-Gn:BSU05860" /db_xref="EnsemblGenomes-Tr:CAB12405" /db_xref="GOA:O05510" /db_xref="InterPro:IPR000600" /db_xref="PDB:1XC3" /db_xref="PDB:3LM9" /db_xref="PDB:3OHR" /db_xref="SubtiList:BG12195" /db_xref="UniProtKB/Swiss-Prot:O05510" /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQY FSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFST DVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHP DDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYIL ILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAG IIGTLVLAHQALQAEAASGEVRS*" gene 612880..613779 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" CDS 613776..614723 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10704478, 18177310, 3017192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphohexomutase; cupin family" /protein_id="NP_388468.1" /db_xref="EnsemblGenomes-Gn:BSU05870" /db_xref="EnsemblGenomes-Tr:CAB12406" /db_xref="GOA:O05511" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG12196" /db_xref="UniProtKB/Swiss-Prot:O05511" /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHA HGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDY AKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKP GDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVIT IPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSG RIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP*" gene 613776..614723 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" CDS 614742..615830 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /EC_number="3.2.1.78" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2694961, 7727534, 18177310, 28101462, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2694961, 7727534, 18177310, 28101462, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported mannan endo-1,4-beta-mannosidase" /protein_id="NP_388469.2" /db_xref="EnsemblGenomes-Gn:BSU05880" /db_xref="EnsemblGenomes-Tr:CAB12407" /db_xref="GOA:O05512" /db_xref="InterPro:IPR000805" /db_xref="InterPro:IPR016714" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR022790" /db_xref="PDB:2WHK" /db_xref="PDB:3CBW" /db_xref="SubtiList:BG12197" /db_xref="UniProtKB/Swiss-Prot:O05512" /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVM NWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETA NIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTV EGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYK QLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSIN GYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNK GASALYHDSWTLNKGEIWNGDSLTPIVE*" gene 614742..615830 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" downshifts 615824 /Source="Nicolas_upshifts" /id="D284" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="1.56881" /MaxDrop="2.87204" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U454" /TUdmin=0 /isTUend="TRUE" CDS complement(615891..616619) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTFRETLAFLIVRDNAHQNAFAKALETLGVEWAKL LPVPNYDINKYPECRKYVELGYHNTHFNFRLDETRISEIYQGKSPSRNGGELQVIDPP AGFPVPVLPEIPNEHSPGLGDMNA*" gene complement(615891..616619) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /pseudo downshifts complement(615941) /Source="Nicolas_upshifts" /id="D285" /incds=0 /nref=13 /ntot=37 /MaxReadThrough="1.1517" /MaxDrop="5.0503" /score="0.317473754" /energy="-17.6" /TU="NA" /idTUdmin="U456" /TUdmin=3 /isTUend="TRUE" CDS complement(616550..616744) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" gene complement(616550..616744) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo promotor_-10 complement(616777..616788) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616785) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" promotor_-35 complement(616802..616808) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 616863..616870 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616884..616903 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 616886..616986 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 616888 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" downshifts complement(616934) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" upshifts 616946 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" promotor_-35 616954..616961 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616975..616994 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 616990..617077 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 616990 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" tRNA 617078..617154 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 617078..617154 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" tRNA 617168..617241 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 617168..617241 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" rRNA 617401..618955 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 617401..618955 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" rRNA 619123..622050 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 619123..622050 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" rRNA 622106..622222 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 622106..622222 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" tRNA 622236..622312 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 622236..622312 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" tRNA 622373..622449 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 622373..622449 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" downshifts 622446 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" promotor_-35 622550..622554 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 622570..622589 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 622574 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" CDS 622630..623607 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" gene 622630..623607 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" CDS 623622..624098 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" gene 623622..624098 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" CDS 624079..624768 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" gene 624079..624768 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" CDS 624778..625233 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" gene 624778..625233 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" CDS 625226..626266 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" gene 625226..626266 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" downshifts 626230 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" CDS complement(626496..628424) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" gene complement(626496..628424) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" downshifts complement(626513) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" misc_feature 628176..628195 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 628186 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" S_feature 628188..628377 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 628342..628349 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 628363..628382 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 628379..628549 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 628379 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" promotor_-10 complement(628444..628463) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(628456) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" promotor_-35 complement(628477..628484) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 628550..629062 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" gene 628550..629062 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" CDS 629059..629706 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" gene 629059..629706 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" promotor_no_box 629536..629636 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 629596 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" CDS 629728..629901 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" gene 629728..629901 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" CDS 629908..630672 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" gene 629908..630672 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" downshifts 630652 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" CDS complement(630710..630901) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" gene complement(630710..630901) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" downshifts complement(630727) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" CDS complement(630898..631632) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" gene complement(630898..631632) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" promotor_-35 631290..631295 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631310..631328 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 631312 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 631631..631632 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 631642..631656 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 631664 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" promotor_-10 complement(631669..631688) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 631686..631794 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(631689) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" promotor_-35 complement(631702..631707) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 631768..631774 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631788..631807 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 631796..631870 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 631796 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" CDS 631871..632155 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" gene 631871..632155 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" CDS 632202..633836 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" gene 632202..633836 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" S_feature 633837..633929 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 633886 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" CDS complement(633924..634052) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" gene complement(633924..634052) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo S_feature 633931..>635157 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(634055..634213) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" gene complement(634055..634213) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo CDS complement(634258..634386) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" gene complement(634258..634386) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo CDS complement(634479..634688) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" gene complement(634479..634688) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo CDS complement(634681..634986) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " gene complement(634681..634986) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo SCAR join(635157,635164) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 635158..635163 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(635262..637751) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" gene complement(635262..637751) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" downshifts complement(635284) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(637765..637784) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(637791) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" promotor_-35 complement(637798..637805) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 637854..637855 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 637870..637952 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 637870 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" promotor_-10 637871..637890 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 637953..639014 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" gene 637953..639014 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" CDS 639088..640479 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" gene 639088..640479 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" promotor_-35 640506..640513 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 640527..640546 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 640532 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" CDS 640574..641536 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" gene 640574..641536 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" downshifts 641521 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" promotor_-35 641661..641670 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 641677 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" promotor_-10 641683..641698 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 641732..642415 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" gene 641732..642415 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" S_feature 642416..642480 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 642481..643506 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" gene 642481..643506 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" CDS 643506..644270 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" gene 643506..644270 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" CDS 644301..645272 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" gene 644301..645272 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" downshifts 645262 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" downshifts 645306 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" CDS complement(645319..646344) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" gene complement(645319..646344) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" promotor_-10 complement(646376..646395) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(646394) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" promotor_-35 complement(646409..646415) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 646604..646611 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 646624 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" S_feature 646626..646928 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 646626..646645 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 646929..648350 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" gene 646929..648350 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" downshifts 648342 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" downshifts complement(648398) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" CDS complement(648398..649438) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" gene complement(648398..649438) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" promotor_-35 648978..648987 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 649001..649020 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 649002..649537 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 649002 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" S_feature complement(649439..649733) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 649538..649557 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 649539..649836 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 649539 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" misc_feature complement(649728..649742) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(649733) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" promotor_-35 649816 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 649835..649854 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 649838 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" CDS 649877..650248 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" gene 649877..650248 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" downshifts 650234 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" CDS 650314..651360 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" gene 650314..651360 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" downshifts 651334 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" CDS complement(651394..651552) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" gene complement(651394..651552) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" downshifts complement(651410) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" S_feature complement(651609..651741) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(651652) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" CDS complement(651742..651951) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" gene complement(651742..651951) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" promotor_-10 complement(651984..652003) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(651995) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" promotor_-35 complement(652020) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(652034..652849) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" gene complement(652034..652849) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" promotor_-35 652676..652685 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 652698..652717 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 652698 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(652862..653851) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" gene complement(652862..653851) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" promotor_-10 complement(653716..653734) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(653724) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" promotor_-35 complement(653750..653755) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(653873..653888) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(653894) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" promotor_-35 complement(653900..653909) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(653949..655490) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" gene complement(653949..655490) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" downshifts complement(653962) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(655521..655540) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(655535) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" promotor_-35 complement(655554..655563) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(655642..657051) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" gene complement(655642..657051) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" downshifts complement(655656) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" CDS complement(657089..657376) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" gene complement(657089..657376) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" misc_feature complement(657092..657111) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(657106) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" promotor_-35 657382..657389 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 657405..657424 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 657406 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" CDS 657449..658321 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" gene 657449..658321 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" downshifts 658286 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" downshifts complement(658561) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" misc_feature 658615..658634 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 658625 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" CDS 658671..659633 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" gene 658671..659633 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" CDS 659633..660829 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" gene 659633..660829 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" CDS 660851..663064 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" gene 660851..663064 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" promotor_-35 663059..663066 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 663081..663100 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 663097..663226 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 663097 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" CDS 663227..664768 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" gene 663227..664768 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" downshifts 664754 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" promotor_-35 664875..664879 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 664895..664914 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 664905 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" misc_RNA 664912..665014 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" gene 664912..665014 /gene="gswC" /locus_tag="BSU_misc_RNA_9" downshifts 665040 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" CDS 665149..666471 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" gene 665149..666471 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" downshifts 666449 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" downshifts 666492 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" promotor_-35 666521..666530 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 666541..666681 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 666541 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" promotor_-10 666543..666558 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 666682..667485 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" gene 666682..667485 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" downshifts 667470 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" promotor_-35 667553..667560 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 667574..667593 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 667580..667643 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 667580 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" CDS 667644..667811 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" gene 667644..667811 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" downshifts 667818 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" promotor_-35 667862..667868 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 667883..667901 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 667886..667972 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 667886 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" promotor_-35 667951..667958 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 667972..667991 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 667974 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" CDS 668025..668579 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" gene 668025..668579 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" CDS 668579..668776 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" gene 668579..668776 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" downshifts 668766 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" promotor_-35 668822..668829 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 668844..668863 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 668846 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" misc_RNA 668856..668958 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" gene 668856..668958 /gene="gswD" /locus_tag="BSU_misc_RNA_10" S_feature 668959..669098 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 669099..669587 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" gene 669099..669587 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" CDS 669580..670722 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" gene 669580..670722 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" CDS 670719..672014 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" gene 670719..672014 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" promotor_-10 complement(671024..671043) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(671045) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(671058..671065) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 672088..672813 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" gene 672088..672813 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" CDS 672806..673060 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" gene 672806..673060 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" CDS 673057..673740 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" gene 673057..673740 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" CDS 673724..675952 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" gene 673724..675952 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" downshifts complement(673972) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" CDS 675928..677358 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" gene 675928..677358 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" S_feature 677359..677459 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 677460..678500 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" gene 677460..678500 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" CDS 678497..679084 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" gene 678497..679084 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" misc_feature 678507..678521 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 678516 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" promotor_-10 complement(678783..678801) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(678790) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(678817..678822) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 679081..680619 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" gene 679081..680619 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" CDS 680635..681903 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" gene 680635..681903 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" downshifts 681888 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" CDS complement(681943..682362) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" gene complement(681943..682362) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" misc_feature complement(682432..682451) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(682441) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" CDS 682506..683780 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" gene 682506..683780 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" downshifts 683729 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" CDS complement(683795..684022) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" gene complement(683795..684022) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" downshifts complement(683806) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" S_feature complement(684023..684443) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 684090..684095 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 684106 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" promotor_-10 684109..684128 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 684151..685893 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" gene 684151..685893 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" promotor_-10 complement(684428..684439) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(684443) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" promotor_-35 complement(684453..684459) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 684474 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" promotor_-35 685867..685873 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 685885 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" promotor_-10 685886..685905 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 685920..686915 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" gene 685920..686915 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" CDS 686918..687232 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" gene 686918..687232 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" downshifts 687095 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" downshifts 687237 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" CDS complement(687267..688844) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" gene complement(687267..688844) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" downshifts complement(687281) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(688858..688877) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(688877) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" promotor_-35 complement(688892..688898) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 689041..689044 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 689058 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" promotor_-10 689061..689080 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 689109..689795 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" gene 689109..689795 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" CDS 689857..692076 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " gene 689857..692076 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" CDS 692100..694106 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" gene 692100..694106 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" CDS 694122..695312 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" gene 694122..695312 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" misc_feature complement(694317..694321) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(694321) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 695349..695368 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 695357..695473 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 695357 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" downshifts complement(695421) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" CDS 695474..696484 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" gene 695474..696484 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" promotor_no_box complement(695491..695591) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(695531) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 696467 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" S_feature 696511..697315 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(696522..697220) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" gene complement(696522..697220) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" downshifts complement(696543) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(697240..697258) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(697261) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" promotor_-35 complement(697274..697279) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(697327..698805) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" gene complement(697327..698805) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" downshifts complement(697341) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" upshifts complement(698193) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" misc_feature complement(698196..698209) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(698806..698936) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(698927..698945) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(698936) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" promotor_-35 complement(698960..698966) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 699067..699070 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 699085..699218 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 699085 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" promotor_-10 699087..699106 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 699219..699509 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" gene 699219..699509 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" CDS 699525..700982 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" gene 699525..700982 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" CDS 700996..702426 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" gene 700996..702426 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" downshifts 702407 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" CDS complement(702441..703310) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" gene complement(702441..703310) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" downshifts complement(702483) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" promotor_-35 703100..703105 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 703121..703139 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 703133 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" S_feature complement(703311..703385) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 703363..703370 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(703379..703398) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 703385 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" promotor_-10 703386..703405 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(703392) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" promotor_-35 complement(703413..703420) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 703442..706600 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" gene 703442..706600 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" downshifts 706587 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" promotor_-35 706839..706842 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706857..706876 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706865 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" CDS 706923..707834 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" gene 706923..707834 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" S_feature 707835..708089 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 708090..709469 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" gene 708090..709469 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" S_feature 709470..710062 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(709482..710384) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" gene complement(709482..710384) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" downshifts 710019 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" S_feature 710064..710364 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 710365..710700 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" gene 710365..710700 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" S_feature 710701..710774 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 710775..713414 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" gene 710775..713414 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" CDS 713426..715225 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" gene 713426..715225 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" promotor_-10 complement(713666..713681) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(713681) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(713693..713702) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 715226..715337 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 715338..716486 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" gene 715338..716486 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" S_feature 716487..717676 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(716748..717053) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " gene complement(716748..717053) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" CDS complement(717120..717326) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" gene complement(717120..717326) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" CDS complement(717566..718021) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" gene complement(717566..718021) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" downshifts complement(717579) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" CDS complement(718041..720050) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" gene complement(718041..720050) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" promotor_-10 complement(718408..718427) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(718415) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" promotor_-35 complement(718440..718445) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(720077..720096) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(720087) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" CDS 720262..721284 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" gene 720262..721284 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" promotor_-35 721384..721391 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 721405..721424 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 721406 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" CDS 721446..722576 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" gene 721446..722576 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" CDS 722566..722739 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" gene 722566..722739 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" downshifts 722694 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" S_feature 722740..722844 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 722811..722818 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 722833..722852 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 722846 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" CDS 722899..723618 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" gene 722899..723618 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" downshifts complement(722901) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" promotor_-35 723476..723483 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 723497..723516 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 723507 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" downshifts 723600 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" promotor_-35 723687..723696 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 723710..723729 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 723713 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" promotor_-10 complement(723717..723735) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(723737) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(723751..723756) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 723752..724189 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" gene 723752..724189 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" downshifts complement(723759) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" downshifts 724189 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" promotor_-35 724249..724256 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 724272..724291 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 724277 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" CDS 724304..724888 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" gene 724304..724888 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" downshifts 724869 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" CDS 724967..725410 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" gene 724967..725410 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" CDS 725407..726267 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" gene 725407..726267 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" promotor_-35 726329..726334 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 726350..726368 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 726350 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" promotor_-10 complement(726372..726386) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(726377) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(726394..726398) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 726394..726642 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" gene 726394..726642 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" CDS 726626..726889 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" gene 726626..726889 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" CDS 726904..727473 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" gene 726904..727473 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" S_feature 727474..727552 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 727525..727530 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 727545..727564 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 727554 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" CDS 727598..728140 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" gene 727598..728140 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" downshifts 728107 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" CDS 728163..728465 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" gene 728163..728465 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" promotor_-35 728508..728516 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 728527..728545 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 728533 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" CDS 728580..729209 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" gene 728580..729209 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" CDS 729206..730939 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" gene 729206..730939 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" CDS 730939..732045 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" gene 730939..732045 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" downshifts 731999 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" promotor_-35 732084..732087 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 732102..732121 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 732109 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 732149..733432 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" gene 732149..733432 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" CDS 733429..734358 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" gene 733429..734358 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" CDS 734362..735252 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" gene 734362..735252 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" CDS 735268..736302 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" gene 735268..736302 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" CDS 736325..738610 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" gene 736325..738610 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" CDS 738624..739322 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" gene 738624..739322 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" CDS 739315..739977 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" gene 739315..739977 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" CDS 739974..740600 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" gene 739974..740600 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" CDS 740721..742583 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" gene 740721..742583 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" promotor_no_box 740761..740861 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 740821 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(741359) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(741360..741379) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(741392..741401) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 742629..744467 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" gene 742629..744467 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" CDS 744625..745278 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " gene 744625..745278 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" CDS 745286..747277 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" gene 745286..747277 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" CDS 747321..749894 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" gene 747321..749894 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" promotor_-10 complement(748643..748661) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(748656) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(748677..748682) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 750016..751524 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" gene 750016..751524 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" CDS 751579..752535 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" gene 751579..752535 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" downshifts complement(751853) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" promotor_no_box complement(751879..751979) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(751919) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 752549..753436 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" gene 752549..753436 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" promotor_-35 753183..753188 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753204..753222 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753207 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" CDS 753445..754785 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" gene 753445..754785 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" S_feature complement(753879..755570) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 754786..754867 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 754868..755563 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" gene 754868..755563 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" downshifts 755561 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" CDS complement(755600..755926) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" gene complement(755600..755926) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" downshifts complement(755615) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" downshifts 755913 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" promotor_-10 complement(755949..755968) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(755967) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" promotor_-35 complement(755983..755990) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(756030..756392) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" gene complement(756030..756392) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" promotor_-10 complement(756415..756434) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(756429) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" promotor_-35 complement(756447..756453) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(756463..757023) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(756495) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(757006..757025) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(757023) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" promotor_-35 complement(757039..757048) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 757111..757118 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 757127 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" promotor_-10 757131..757150 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 757176..757757 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" gene 757176..757757 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo CDS 757751..758047 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" gene 757751..758047 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo downshifts 758039 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" promotor_-35 758118..758125 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 758139..758158 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 758147 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" CDS 758202..758369 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" gene 758202..758369 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" promotor_-35 758411..758418 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 758434..758453 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 758435 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" CDS 758479..759123 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" gene 758479..759123 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" downshifts 759059 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" downshifts 759103 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" CDS 759123..760115 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" gene 759123..760115 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" downshifts 760049 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" downshifts 760093 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" CDS complement(760139..760642) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" gene complement(760139..760642) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" promotor_-10 complement(760667..760686) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(760675) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" promotor_-35 complement(760700..760707) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 760805..761914 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" gene 760805..761914 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" downshifts 761897 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" CDS complement(761949..763019) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" gene complement(761949..763019) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" downshifts complement(761973) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(763050..763069) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(763076) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" promotor_-35 complement(763084..763091) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 763099..763105 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 763120..763138 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 763129 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" CDS 763169..766354 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" gene 763169..766354 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" downshifts 766341 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" promotor_-35 766404..766409 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 766425..766443 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 766446 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" promotor_-35 766474..766477 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 766494..766513 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 766495..766800 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 766495 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" CDS 766801..768720 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" gene 766801..768720 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" downshifts 768719 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" promotor_-35 768808..768817 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 768827..768955 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 768827 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" promotor_-10 768831..768850 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(768881) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" CDS 768956..769720 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" gene 768956..769720 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" CDS 769727..770695 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" gene 769727..770695 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" CDS 770719..771630 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" gene 770719..771630 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" promotor_-35 771508..771517 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 771530..771549 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 771533 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" CDS 771659..772837 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" gene 771659..772837 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" promotor_-35 772378..772384 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 772399..772418 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 772413 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 772838..773773 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" gene 772838..773773 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" downshifts 773645 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" downshifts 773755 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" downshifts complement(773796) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" CDS complement(773804..775033) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" gene complement(773804..775033) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" promotor_-10 complement(775062..775081) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(775080) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" promotor_-35 complement(775097..775104) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(775144..775851) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" gene complement(775144..775851) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" downshifts complement(775173) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" misc_feature complement(775874..775893) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(775897) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" CDS complement(775943..777328) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" gene complement(775943..777328) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" downshifts complement(775965) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(777377..777396) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(777394) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" promotor_-35 complement(777411..777418) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 777496..777503 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 777511 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" promotor_-10 777517..777535 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 777578..779035 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" gene 777578..779035 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" promotor_-10 complement(778371..778390) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(778385) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(778403..778412) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 779049..779909 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" gene 779049..779909 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" downshifts 779893 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" promotor_-35 779977..779984 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 779998..780017 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 780003 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" CDS 780044..781933 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" gene 780044..781933 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" downshifts 781917 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" misc_feature 781997..782016 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 782005 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" CDS 782056..782502 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" gene 782056..782502 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" downshifts complement(782058) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(782142..782145) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(782147) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(782163..782164) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 782489 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" promotor_-35 782565..782572 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 782586..782605 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 782598 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" CDS 782627..783049 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" gene 782627..783049 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" downshifts 782885 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" CDS 783115..784305 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" gene 783115..784305 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" downshifts complement(784369) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" CDS 784596..784751 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" gene 784596..784751 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" CDS complement(784871..786427) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" gene complement(784871..786427) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" downshifts complement(784895) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" promotor_-35 786257..786263 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786278..786289 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786295 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" promotor_-10 complement(786477..786496) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786481) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" promotor_-35 complement(786512..786516) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 786537..786540 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786556..786575 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786559 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" CDS 786600..787730 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" gene 786600..787730 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" downshifts 787713 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" CDS 787798..788244 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" gene 787798..788244 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" CDS complement(788297..789316) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" gene complement(788297..789316) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" downshifts complement(788307) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(789337..789356) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(789341) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" S_feature complement(789343..789797) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(789369..789376) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 789435..789442 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 789456..789475 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 789463..790560 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 789463 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" CDS complement(789798..791018) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" gene complement(789798..791018) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" promotor_-10 complement(791055..791074) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(791062) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" promotor_-35 complement(791090..791097) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 791116..791123 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 791135..791310 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 791135 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" promotor_-10 791138..791157 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 791267 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" CDS 791354..792817 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" gene 791354..792817 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" S_feature complement(791719..793389) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 792818..793311 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 793299..793304 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 793313..796578 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 793313 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" promotor_-10 793320..793338 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(793390..794190) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" gene complement(793390..794190) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" CDS complement(794203..795204) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " gene complement(794203..795204) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" promotor_-10 complement(794790..794809) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(794802) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" promotor_-35 complement(794824..794831) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(795201..796202) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " gene complement(795201..796202) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" misc_feature complement(796272..796291) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(796274..797221) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" gene complement(796274..797221) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" downshifts complement(796293) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" upshifts complement(796293) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" promotor_-35 796548..796553 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796569..796587 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 796580..797205 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 796580 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" misc_feature 797201..797220 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 797207..797738 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 797207 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" promotor_-10 complement(797263..797282) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(797270) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" promotor_-35 complement(797296..797303) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(797330..797698) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" gene complement(797330..797698) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" S_feature complement(797699..797811) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(797800..797819) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(797811) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" promotor_-35 complement(797831..797838) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 797879..797885 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 797899..797917 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 797899 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" CDS 797942..798289 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" gene 797942..798289 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" downshifts complement(797943) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" downshifts 798285 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" S_feature 798330..798410 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 798411..798430 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 798412 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" CDS 798480..799742 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" gene 798480..799742 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" downshifts 799737 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" promotor_-35 799795..799798 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799813..799832 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799821 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" CDS 799869..801305 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" gene 799869..801305 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" downshifts 801297 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" misc_feature 801396..801415 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 801407 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" CDS 801432..803060 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" gene 801432..803060 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" CDS 803032..803712 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" gene 803032..803712 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" CDS 803715..804674 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" gene 803715..804674 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" downshifts 804643 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" promotor_-35 804766..804773 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 804786..804805 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 804797..804869 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 804797 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" CDS 804870..806171 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" gene 804870..806171 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" promotor_-35 806168..806174 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 806188..806199 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 806189 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" CDS 806227..807021 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" gene 806227..807021 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" downshifts 806997 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" promotor_-35 807076..807079 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 807094..807113 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 807107 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" CDS 807140..808231 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" gene 807140..808231 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" CDS complement(808222..808497) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" gene complement(808222..808497) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" S_feature 808232..808563 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(808511..808530) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(808525) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" promotor_-35 complement(808545..808552) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 808564..809229 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" gene 808564..809229 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" CDS complement(809270..809407) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" gene complement(809270..809407) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" downshifts complement(809284) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" S_feature complement(809408..809538) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(809524..809542) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 809534..809539 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(809538) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" S_feature 809549..810613 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 809550 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" promotor_-10 809555..809573 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(809558..809563) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(809564..809719) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" gene complement(809564..809719) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" S_feature complement(809720..809825) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(809826..810140) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" gene complement(809826..810140) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" S_feature complement(810141..810221) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(810222..810971) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" gene complement(810222..810971) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" promotor_-10 complement(811000..811019) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811013) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" S_feature complement(811015..812151) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(811031..811039) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 811082..811083 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811103..811122 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811106 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" CDS 811143..812501 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" gene 811143..812501 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" promotor_-10 complement(812137..812156) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(812151) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" promotor_-35 complement(812170..812179) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 812387 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" downshifts 812497 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" CDS complement(812534..814483) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" gene complement(812534..814483) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" downshifts complement(812551) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" promotor_-35 813593..813599 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 813615..813633 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 813619..814583 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 813619 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" S_feature complement(814484..814558) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(814535..814554) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814558) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" S_feature complement(814560..815082) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(814570..814574) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 814584..814721 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" gene 814584..814721 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" upshifts 814699 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" misc_feature 814700..814719 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 814740..815132 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" gene 814740..815132 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" promotor_-10 complement(815080..815098) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(815095) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" promotor_-35 complement(815114..815119) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 815201..815207 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 815222..815240 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 815222 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" CDS 815257..816672 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" gene 815257..816672 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" downshifts complement(815258) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" promotor_no_box complement(815284..815384) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(815324) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(816669..817745) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" gene complement(816669..817745) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" S_feature 816673..820039 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(817769..817969) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" gene complement(817769..817969) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" CDS complement(817985..819139) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" gene complement(817985..819139) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" CDS complement(819120..820661) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" gene complement(819120..820661) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" promotor_-10 complement(820711..820722) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(820714) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" promotor_-35 complement(820736..820742) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 820771..820778 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 820793..820812 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 820800 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" downshifts complement(820846) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" CDS 820854..822266 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" gene 820854..822266 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" promotor_no_box complement(820872..820972) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(820912) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 822337..824022 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" gene 822337..824022 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" promotor_-10 complement(822643..822658) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(822650) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(822671..822680) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 823995..823999 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824015..824034 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824018 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" CDS 824043..824759 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" gene 824043..824759 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" downshifts 824752 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" promotor_-35 824834..824837 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824853..824872 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824862 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" CDS 824899..825564 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" gene 824899..825564 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" downshifts 825545 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" CDS complement(825601..829989) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" gene complement(825601..829989) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" downshifts complement(825620) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(830022..830041) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(830039) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" promotor_-35 complement(830056..830059) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 830166..830172 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 830186..830204 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 830189 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" CDS 830232..830750 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" gene 830232..830750 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" downshifts 830736 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" downshifts complement(830780) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" S_feature 830781..832431 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(830790..831980) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" gene complement(830790..831980) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" S_feature complement(831981..832072) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(832073..832288) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" gene complement(832073..832288) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" downshifts complement(832132) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" promotor_-10 complement(832320..832339) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(832334) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" promotor_-35 complement(832354..832355) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 832401..832408 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832423..832442 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 832433 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" CDS 832491..832961 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" gene 832491..832961 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" CDS 832979..833299 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" gene 832979..833299 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" CDS 833323..834150 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " gene 833323..834150 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" promotor_-35 834129..834135 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 834150..834161 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 834168..834324 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 834168 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" downshifts complement(834200) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" downshifts 834299 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" CDS complement(834349..835524) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " gene complement(834349..835524) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" downshifts complement(834354) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" promotor_-35 834961..834967 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 834983..835001 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 834987..835640 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 834987 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" promotor_-10 complement(835549..835568) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(835564) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" promotor_-35 complement(835582..835589) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 835630..835635 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 835642 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" promotor_-10 835650..835668 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 835692..836747 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" gene 835692..836747 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" promotor_-35 836761..836767 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 836782..836793 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 836786 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" CDS 836818..837612 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" gene 836818..837612 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" downshifts 837600 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" CDS complement(837651..838493) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" gene complement(837651..838493) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" downshifts complement(837653) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" CDS complement(838494..839615) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" gene complement(838494..839615) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" promotor_-10 complement(839656..839675) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(839674) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" promotor_-35 complement(839691..839695) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 839703..839710 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 839724..839743 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 839734 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" CDS 839760..839945 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" gene 839760..839945 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" downshifts 839924 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" promotor_-35 839988..839994 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 840000 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" promotor_-10 840009..840020 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 840046..840837 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" gene 840046..840837 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" downshifts 840835 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" CDS complement(840875..841735) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" gene complement(840875..841735) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" downshifts complement(840889) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(841755..841774) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(841769) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" promotor_-35 complement(841790..841793) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(841834..842793) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" gene complement(841834..842793) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" downshifts complement(841857) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(842804..842823) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(842807) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" promotor_-35 complement(842839..842842) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 842854..842858 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 842872..842891 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 842881 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" CDS 842912..843775 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" gene 842912..843775 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" S_feature 843776..843888 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 843889..845289 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" gene 843889..845289 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" downshifts 845301 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" promotor_-35 845595..845602 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 845618..845637 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 845624 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" S_feature 845631..845914 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 845915..846181 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" gene 845915..846181 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" promotor_-10 complement(846129..846148) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(846147) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(846163..846166) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 846182..846663 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 846634..846637 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846654..846673 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 846665..846912 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 846665 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" CDS 846913..847890 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" gene 846913..847890 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" S_feature 847891..847983 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 847940 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" promotor_-35 848024..848030 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 848042..848061 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 848051 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" CDS 848086..848538 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" gene 848086..848538 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" CDS 848568..849257 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" gene 848568..849257 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" downshifts 849262 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" misc_feature 849434..849452 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 849441 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" CDS 849489..850490 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " gene 849489..850490 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" CDS 850494..851522 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" gene 850494..851522 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" CDS 851536..852732 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" gene 851536..852732 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" downshifts complement(851537) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" CDS 852753..854129 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" gene 852753..854129 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" downshifts 854123 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" promotor_-35 854176..854183 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854196..854215 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 854204 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" CDS 854245..856062 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" gene 854245..856062 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" promotor_-35 856063..856069 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 856081 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" promotor_-10 856084..856095 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 856116..856295 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" gene 856116..856295 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" downshifts 856279 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" CDS complement(856331..856660) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" gene complement(856331..856660) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" downshifts complement(856345) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" CDS complement(856710..857168) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" gene complement(856710..857168) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" S_feature complement(857169..857261) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(857262..857819) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" gene complement(857262..857819) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" promotor_-35 857685..857690 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 857698 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" promotor_-10 857705..857723 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 857709..858296 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(857851..858618) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" gene complement(857851..858618) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" CDS complement(858630..859853) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" gene complement(858630..859853) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" CDS complement(859859..860173) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" gene complement(859859..860173) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" promotor_-10 complement(860221..860240) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(860234) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" promotor_-35 complement(860255..860258) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 860465..860484 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 860468 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" CDS 860509..861858 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " gene 860509..861858 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" misc_feature 861887..861906 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 861889 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" CDS 861923..862687 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" gene 861923..862687 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" promotor_-10 complement(862067..862081) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(862097..862103) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(862097) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 862702..864285 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" gene 862702..864285 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" downshifts 864265 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" promotor_-35 864314..864321 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 864336..864355 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 864344 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" CDS 864391..866112 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" gene 864391..866112 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" CDS 866106..867920 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" gene 866106..867920 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" downshifts 867895 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" promotor_-35 868002..868009 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868023..868042 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868027 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" CDS 868075..868479 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" gene 868075..868479 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" CDS 868497..869354 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" gene 868497..869354 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" downshifts 869341 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" CDS 869448..870392 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" gene 869448..870392 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" downshifts complement(870259) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" promotor_no_box complement(870307..870407) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(870347) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 870567..872015 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" gene 870567..872015 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" CDS 872042..872983 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" gene 872042..872983 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" CDS 872993..874174 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" gene 872993..874174 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" downshifts 874164 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" promotor_-35 874234..874240 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 874255..874274 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 874273 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" CDS 874298..875500 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" gene 874298..875500 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" CDS 875497..876159 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" gene 875497..876159 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" downshifts 876167 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" CDS 876303..877238 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" gene 876303..877238 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" CDS 877251..878441 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" gene 877251..878441 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" CDS 878455..879612 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" gene 878455..879612 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" promotor_-35 878566..878571 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 878586..878604 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 878587 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(879610..879684) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(879653) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" CDS complement(879685..880233) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" gene complement(879685..880233) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" S_feature complement(880234..880313) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(880302..880321) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(880313) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" promotor_-35 complement(880335..880340) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 880436..880439 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 880455..880474 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 880462 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" CDS 880506..881138 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" gene 880506..881138 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" downshifts 881117 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" promotor_-35 881253..881258 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 881272..881291 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 881282 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" CDS 881327..882415 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" gene 881327..882415 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" S_feature complement(881817..882205) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(882205) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" promotor_-10 complement(882207..882226) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(882239..882247) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(882451..883068) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" gene complement(882451..883068) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" downshifts complement(882469) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" CDS complement(883034..884287) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" gene complement(883034..884287) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" promotor_-10 complement(883095..883114) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(883107) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" promotor_-35 complement(883128..883135) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(884321..884340) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(884339) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(884355..884362) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 884366..884385 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 884371 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" CDS 884411..884947 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" gene 884411..884947 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" CDS complement(884944..886500) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" gene complement(884944..886500) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" promotor_-10 complement(886522..886540) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886539) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(886556..886559) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(886611..887093) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" gene complement(886611..887093) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" downshifts complement(886627) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(887118..887137) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(887134) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" promotor_-35 complement(887152..887158) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 887179..887186 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887200..887219 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887208 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" CDS 887265..889835 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" gene 887265..889835 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" downshifts 889806 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" CDS complement(889853..890830) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" gene complement(889853..890830) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" downshifts complement(889864) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" promotor_-35 890845..890852 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(890857..890876) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 890867..890886 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 890869..890960 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 890869 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" upshifts complement(890874) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" promotor_-35 complement(890891..890898) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 890961..891962 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " gene 890961..891962 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" CDS 891959..892990 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" gene 891959..892990 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" downshifts 892971 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" promotor_-35 893041..893043 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 893059..893078 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893062 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" CDS 893105..893986 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" gene 893105..893986 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" promotor_-35 893997..894004 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894020..894039 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894029 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" CDS 894074..894658 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" gene 894074..894658 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" downshifts 894645 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" CDS complement(894697..894888) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" gene complement(894697..894888) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" downshifts complement(894715) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" upshifts complement(894920) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" promotor_-10 complement(894923..894934) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(894949..894955) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(894955..895065) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" gene complement(894955..895065) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" promotor_-10 complement(895094..895105) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(895096) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" promotor_-35 complement(895120..895126) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(895120..896031) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" gene complement(895120..896031) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" promotor_-35 895917..895920 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 895937..895956 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 895947..896119 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 895947 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" promotor_-10 complement(896053..896071) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(896067) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" promotor_-35 complement(896085..896091) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 896120..896914 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" gene 896120..896914 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" CDS 896916..897230 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" gene 896916..897230 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" S_feature complement(897138..897406) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 897220 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" promotor_-35 897304..897309 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 897325..897344 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 897330 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" CDS 897373..898566 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" gene 897373..898566 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" S_feature 898567..898801 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(898599..898751) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" gene complement(898599..898751) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" downshifts complement(898616) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" promotor_-35 898780..898787 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 898801..898820 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 898803..898875 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 898803 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" promotor_-10 complement(898810..898821) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(898820) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" promotor_-35 complement(898836..898842) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 898876..899145 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" gene 898876..899145 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" downshifts 899134 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" promotor_-35 899223..899229 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 899244 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" promotor_-10 899245..899263 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 899290..899808 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" gene 899290..899808 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" S_feature 899809..899876 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 899844..899853 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 899865..899880 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 899878 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" CDS 899893..900225 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" gene 899893..900225 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" CDS 900212..901072 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" gene 900212..901072 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" downshifts 901070 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" promotor_-35 901130..901136 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901150..901161 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 901158..901222 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 901158 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" promotor_-10 complement(901180..901199) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(901189) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 901205..901211 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(901213..901214) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 901224..901304 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 901224 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" promotor_-10 901226..901244 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 901305..902294 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" gene 901305..902294 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" upshifts complement(901454) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(901459..901463) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(901480..901484) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 902295..902365 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 902366..904951 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" gene 902366..904951 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" downshifts 904920 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" CDS complement(904944..905927) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" gene complement(904944..905927) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" downshifts complement(904978) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" promotor_-35 905401..905410 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 905423..905442 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 905427 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(905928..906075) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 906032..906036 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 906052..906071 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 906059 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" S_feature 906065..906142 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(906073..906092) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(906075) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" promotor_-35 complement(906107..906114) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 906143..907252 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" gene 906143..907252 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" promotor_-35 907089..907093 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 907109..907128 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 907121 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" S_feature 907253..907565 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(907260..907484) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" gene complement(907260..907484) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" promotor_-10 complement(907514..907525) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(907516) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" promotor_-35 complement(907539..907545) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 907566..908318 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" gene 907566..908318 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" promotor_-35 908335..908341 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908356..908367 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908357 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" promotor_-10 complement(908364..908378) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908385) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(908387..908391) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 908387..908641 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" gene 908387..908641 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" downshifts 908639 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" downshifts complement(908664) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" CDS 908730..909074 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" gene 908730..909074 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" promotor_-35 908737..908745 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908756..908774 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908758 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" downshifts 909057 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" promotor_-35 909113..909120 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 909134..909153 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 909143..909217 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 909143 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" CDS 909218..909748 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" gene 909218..909748 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" downshifts 909739 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" CDS 909836..911578 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" gene 909836..911578 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" downshifts 911565 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" CDS complement(911655..912716) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" gene complement(911655..912716) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" downshifts complement(911666) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" S_feature complement(912717..912807) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(912805..912824) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(912814) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" promotor_-35 complement(912839..912846) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(912936..914225) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" gene complement(912936..914225) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" downshifts complement(912939) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(914253..914272) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(914272) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" S_feature complement(914274..914985) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(914284..914289) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 914318..914325 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 914339..914358 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 914339 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" CDS 914378..914851 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" gene 914378..914851 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" promotor_-35 914888..914895 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 914910..914929 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 914916 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" CDS 914974..915411 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" gene 914974..915411 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" downshifts 915393 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" CDS complement(915446..915799) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" gene complement(915446..915799) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" downshifts 915459 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" downshifts complement(915469) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" promotor_-35 915795..915799 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 915807..915821 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(915811..915830) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 915811..915902 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 915811 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" upshifts complement(915821) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" promotor_-35 915879..915882 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 915897..915916 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 915904..916006 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 915904 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" CDS 916007..916891 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" gene 916007..916891 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" promotor_-35 916874..916881 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916895..916914 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 916910..917182 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 916910 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" downshifts complement(916943) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" rRNA 917183..918737 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 917183..918737 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" rRNA 918905..921832 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 918905..921832 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" S_feature 921833..921918 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 921894..921901 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 921915..921934 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 921920 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" rRNA 921944..922059 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 921944..922059 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" tRNA 922069..922143 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922069..922143 /gene="asnTA" /locus_tag="BSU_tRNA_29" tRNA 922149..922240 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922149..922240 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" downshifts 922236 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" tRNA 922275..922346 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922275..922346 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" tRNA 922356..922431 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922356..922431 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" tRNA 922441..922517 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922441..922517 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" tRNA 922529..922605 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922529..922605 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" tRNA 922618..922693 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922618..922693 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" tRNA 922699..922771 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922699..922771 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" tRNA 922794..922878 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922794..922878 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" tRNA 922884..922957 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922884..922957 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" tRNA 922982..923057 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 922982..923057 /gene="trnD-His" /locus_tag="BSU_tRNA_39" tRNA 923067..923138 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 923067..923138 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" tRNA 923188..923262 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 923188..923262 /gene="glyTB" /locus_tag="BSU_tRNA_41" tRNA 923268..923338 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 923268..923338 /gene="cysTA" /locus_tag="BSU_tRNA_42" tRNA 923346..923434 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 923346..923434 /gene="leuTA" /locus_tag="BSU_tRNA_43" S_feature 923435..923511 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 923468 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" S_feature 923513..923681 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 923638..923645 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 923644 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" promotor_-10 923659..923678 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 923683 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" tRNA 923700..923781 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 923700..923781 /gene="leuTB" /locus_tag="BSU_tRNA_44" promotor_-10 complement(923717..923734) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(923720) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(923755..923760) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(923790) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" CDS complement(923860..924636) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" gene complement(923860..924636) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" downshifts complement(923874) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(924663..924678) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(924685) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" promotor_-35 complement(924691..924700) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 924720..924726 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 924741..924752 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 924744 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" CDS 924778..924981 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" gene 924778..924981 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" downshifts 924964 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" downshifts complement(925040) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" CDS complement(925066..925338) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" gene complement(925066..925338) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" promotor_-10 complement(925297..925315) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(925304) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" promotor_-35 925319..925326 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(925332..925337) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925339..925358 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 925347 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" CDS 925380..926072 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" gene 925380..926072 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" promotor_-35 926101..926105 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(926104..926123) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(926116) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 926119..926138 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(926138..926145) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 926142..926249 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 926142..926249 /gene="tswD" /locus_tag="BSU_misc_RNA_11" upshifts 926149 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" downshifts 926280 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" CDS 926382..928154 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" gene 926382..928154 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" downshifts 928130 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" S_feature 928175..929100 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(928192..929547) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" gene complement(928192..929547) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" promotor_-10 complement(929575..929594) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(929592) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" promotor_-35 complement(929608..929617) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 929665..929671 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 929686..929705 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 929714 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" CDS 929798..929995 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" gene 929798..929995 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" CDS complement(930022..931473) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" gene complement(930022..931473) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" downshifts complement(930032) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" promotor_-35 931450..931456 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 931471..931490 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 931474 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" promotor_-10 complement(931491..931510) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 931496..931825 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(931510) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" promotor_-35 complement(931524..931531) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(931569..931587) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(931594) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" downshifts 931782 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" CDS 931881..932648 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" gene 931881..932648 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" CDS 932666..933664 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" gene 932666..933664 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" CDS 933661..934491 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" gene 933661..934491 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" CDS 934514..935644 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" gene 934514..935644 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" misc_feature 935671..935690 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 935677 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" CDS 935748..936284 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" gene 935748..936284 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" S_feature 936285..936355 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 936325..936332 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936346..936365 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936357 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" CDS 936396..936665 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" gene 936396..936665 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" promotor_-35 936468..936472 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936495..936511 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936511 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 936652 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" CDS complement(936683..937156) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" gene complement(936683..937156) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" downshifts complement(936719) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" CDS complement(937158..937358) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" gene complement(937158..937358) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" promotor_-10 complement(937387..937406) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937401) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" promotor_-35 complement(937419..937426) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 937482..937487 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 937501..937520 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 937501 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" tRNA 937552..937625 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 937552..937625 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" S_feature 937626..937808 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(937716..938339) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" gene complement(937716..938339) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" downshifts complement(937731) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" downshifts 937765 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" S_feature 937810..938421 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(938363..938382) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938384) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" promotor_-35 complement(938396..938403) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 938422..939582 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" gene 938422..939582 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" downshifts 939591 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" misc_feature 939608..939620 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 939613 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" CDS 939649..940584 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" gene 939649..940584 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" downshifts complement(939667) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" promotor_-35 940568..940571 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 940586 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" promotor_-10 940587..940606 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 940622..941104 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" gene 940622..941104 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" downshifts 941087 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" CDS 941154..941870 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" gene 941154..941870 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" promotor_-35 941174..941181 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 941196..941215 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 941197 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" CDS 941861..942574 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" gene 941861..942574 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" CDS 942586..943293 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" gene 942586..943293 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" downshifts 943177 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" downshifts 943221 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" downshifts 943287 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" S_feature complement(943320..943495) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(943363) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" promotor_-10 complement(943487..943506) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(943495) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" promotor_-35 complement(943521..943528) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 943560..943565 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 943581..943599 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943581 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" CDS 943643..945538 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" gene 943643..945538 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" promotor_no_box 944085..944185 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 944145 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 944211 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" downshifts 945531 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" promotor_-35 945595..945600 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 945616..945634 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 945619..945717 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 945619 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" CDS 945718..946896 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" gene 945718..946896 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" promotor_-35 945916..945919 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 945934..945953 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 945938 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(946179) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" downshifts 946875 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" promotor_-35 946983..946990 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947005..947024 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947005 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" CDS 947056..947520 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" gene 947056..947520 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" promotor_-35 947345..947351 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947366..947384 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947379 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" promotor_-35 947529..947535 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947549..947560 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947555 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" CDS 947556..948221 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" gene 947556..948221 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" CDS 948262..949860 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" gene 948262..949860 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" CDS 949883..950413 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" gene 949883..950413 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" CDS 950426..950800 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" gene 950426..950800 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" downshifts 950789 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" CDS 950800..950955 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" gene 950800..950955 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" promotor_-35 950890..950896 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 950911..950930 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 950921 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" CDS 950960..951721 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" gene 950960..951721 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" promotor_-10 complement(951273..951291) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951287) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(951307..951312) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 951724..952089 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" gene 951724..952089 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" CDS 952091..952789 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" gene 952091..952789 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" CDS 952806..953723 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" gene 952806..953723 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" CDS 953716..954657 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" gene 953716..954657 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" downshifts 954639 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" CDS complement(954749..954952) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" gene complement(954749..954952) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" downshifts complement(954763) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" S_feature complement(954953..955080) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 955040..955051 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 955057 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(955069..955088) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(955080) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" S_feature complement(955082..956220) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(955102..955107) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 955247..955254 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955269..955287 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955276 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" S_feature 955277..955387 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 955388..956218 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" gene 955388..956218 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" downshifts 956177 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" CDS complement(956221..957300) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" gene complement(956221..957300) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" promotor_-10 complement(957310..957329) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(957331) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" promotor_-35 complement(957345..957349) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 957407..957414 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 957428..957447 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 957434 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" CDS 957473..958864 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" gene 957473..958864 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" S_feature complement(958500..958903) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 958843 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" CDS complement(958904..959359) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" gene complement(958904..959359) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" promotor_-10 complement(959374..959392) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(959402) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" promotor_-35 complement(959407..959413) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 959451..959457 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 959471..959482 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 959475 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" CDS 959509..960078 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" gene 959509..960078 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" promotor_-35 959705..959711 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 959722 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 959725..959736 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 960053 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" promotor_-35 960121..960130 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 960144..960163 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 960154 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" CDS 960199..961167 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" gene 960199..961167 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" downshifts 961043 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" CDS complement(961099..961752) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " gene complement(961099..961752) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" downshifts complement(961116) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" promotor_-10 complement(961783..961794) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(961785) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" promotor_-35 complement(961809..961815) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 961824..961832 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 961835..965488 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" gene 961835..965488 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" promotor_-10 961843..961861 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 961858 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" CDS 965485..966081 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" gene 965485..966081 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" downshifts 966060 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" CDS complement(966111..967019) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" gene complement(966111..967019) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" promotor_-35 967075..967083 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(967076..967087) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(967082) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" S_feature complement(967084..967570) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 967094 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" promotor_-10 967097..967116 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(967101..967107) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 967130..967525 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" gene 967130..967525 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" misc_feature complement(967556..967575) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(967570) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" promotor_-35 967610..967616 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 967625 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" promotor_-10 967630..967641 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(967640..967654) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(967654) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(967662..967666) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 967662..968084 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" gene 967662..968084 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" promotor_no_box complement(967988..968088) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(968028) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 968062 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" downshifts complement(968094) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" promotor_-35 968134..968141 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968155..968174 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 968163 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" CDS 968211..968873 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" gene 968211..968873 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" CDS 968889..970430 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" gene 968889..970430 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" downshifts 970413 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" CDS 970514..970705 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" gene 970514..970705 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo promotor_-35 970736..970743 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 970758..970777 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 970769..970850 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 970769 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" CDS 970851..972203 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" gene 970851..972203 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" CDS 972231..972809 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" gene 972231..972809 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" promotor_-35 972804..972811 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 972826..972845 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 972837 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" downshifts 972852 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" S_feature 972897..972987 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 972988..973812 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" gene 972988..973812 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" CDS 973831..975321 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" gene 973831..975321 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" promotor_-35 974632..974638 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 974653..974672 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 974663 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" S_feature 975322..975410 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 975367 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" promotor_no_box 975373..975473 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 975433 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" CDS 975462..977129 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" gene 975462..977129 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" promotor_-35 976891..976896 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 976911..976929 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 976920 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" promotor_-35 976974..976980 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 976995 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" promotor_-10 976996..977014 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 977097 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" S_feature 977142..977215 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 977197..977204 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 977217 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" promotor_-10 977218..977237 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 977261..979006 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" gene 977261..979006 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" downshifts 978995 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" S_feature 979040..979109 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 979111..979130 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 979111 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" CDS 979155..980294 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" gene 979155..980294 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" CDS 980291..980935 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" gene 980291..980935 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" CDS 980932..981456 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" gene 980932..981456 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" downshifts 981421 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" CDS complement(981471..981713) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" gene complement(981471..981713) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" downshifts complement(981492) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" promotor_-10 complement(981749..981760) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(981760) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" promotor_-35 complement(981774..981781) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 981848..981854 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 981868..981879 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 981878 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" CDS 981914..982237 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" gene 981914..982237 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" S_feature 982238..984104 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(982279..983745) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" gene complement(982279..983745) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" downshifts complement(982291) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" downshifts complement(982378) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(983785..983803) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983797) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" promotor_-35 complement(983817..983824) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(983898..984338) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" gene complement(983898..984338) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" downshifts complement(983928) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" promotor_-35 984326..984332 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 984346..984357 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 984348..984458 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 984348 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" promotor_-10 complement(984360..984379) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(984376) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" promotor_-35 complement(984391..984397) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 984417 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" CDS complement(984445..986103) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" gene complement(984445..986103) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" downshifts complement(984450) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" promotor_-10 complement(985994..986012) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(986014) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" promotor_-35 complement(986026..986032) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 986075..986080 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986096..986114 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986109 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" CDS 986134..987540 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" gene 986134..987540 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" downshifts 987520 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" CDS complement(987570..988955) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" gene complement(987570..988955) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" downshifts complement(987596) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" upshifts complement(988982) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" S_feature complement(988984..990515) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(988992..989003) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 989111..989118 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 989131..989150 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 989137..989424 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 989137 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" promotor_-35 989387..989390 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 989405..989424 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 989426 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" CDS 989485..990489 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" gene 989485..990489 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" downshifts 990351 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" downshifts 990481 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" upshifts complement(990515) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" promotor_-10 complement(990522..990537) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 990527 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" promotor_-35 complement(990549..990558) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(990560..991435) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" gene complement(990560..991435) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" promotor_-35 991488..991489 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(991501..991520) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 991506..991525 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(991507) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" upshifts 991516 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" promotor_-35 complement(991535..991540) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 991544..992644 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" gene 991544..992644 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" promotor_-35 992655..992661 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 992676..992694 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 992681 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" CDS 992718..993587 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" gene 992718..993587 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" downshifts 993595 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" promotor_-35 993672..993675 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 993687 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" promotor_-10 993690..993709 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 993735..993754 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 993740..993836 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 993740 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" CDS 993837..995234 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" gene 993837..995234 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" downshifts 995214 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" promotor_-35 995295..995299 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 995315..995334 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 995322 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" CDS 995352..996707 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" gene 995352..996707 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" downshifts 996688 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" CDS complement(996742..998151) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" gene complement(996742..998151) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" promotor_-35 998200..998203 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 998218..998237 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 998220 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" promotor_-10 complement(998222..998241) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(998234) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" promotor_-35 complement(998257..998261) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 998261..998689 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" gene 998261..998689 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" downshifts 998668 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" CDS complement(998720..999010) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" gene complement(998720..999010) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" downshifts complement(998744) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" CDS complement(998998..1000074) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" gene complement(998998..1000074) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" CDS complement(1000064..1000555) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" gene complement(1000064..1000555) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" S_feature complement(1000556..1000658) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(1000647..1000666) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000658) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" promotor_-35 complement(1000680..1000683) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1000696..1000702 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1000713 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" promotor_-10 1000717..1000735 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1000746) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" CDS 1000752..1001747 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" gene 1000752..1001747 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" downshifts 1001726 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" promotor_-35 1001809..1001812 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1001827..1001846 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1001832 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" CDS 1001882..1002481 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" gene 1001882..1002481 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" downshifts 1002496 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" S_feature 1002541..1004495 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(1002550..1003884) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" gene complement(1002550..1003884) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" downshifts complement(1002569) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" CDS complement(1003945..1004376) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" gene complement(1003945..1004376) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" promotor_-10 complement(1004388..1004407) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1004398) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" promotor_-35 complement(1004422..1004428) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(1004424..1004524) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 1004459..1004466 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(1004464) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1004480..1004499 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 1004497 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" CDS 1004533..1005714 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" gene 1004533..1005714 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" downshifts 1005699 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" S_feature 1005744..1005882 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 1005878..1005897 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1005884..1006040 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 1005884 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" CDS 1006041..1007426 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" gene 1006041..1007426 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" downshifts 1007316 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" downshifts 1007402 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" CDS complement(1007440..1007796) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" gene complement(1007440..1007796) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" CDS complement(1007793..1008188) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" gene complement(1007793..1008188) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" CDS complement(1008175..1008906) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" gene complement(1008175..1008906) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" misc_feature complement(1008931..1008950) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1008952) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" promotor_-35 1008999..1009007 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1009016 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" promotor_-10 1009021..1009036 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1009030..1009103 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 1009090..1009091 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1009105 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" promotor_-10 1009107..1009126 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1009140..1009247 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" gene 1009140..1009247 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" S_feature 1009248..1009301 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 1009272 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" misc_feature 1009352..1009371 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1009358 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" CDS 1009396..1010511 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" gene 1009396..1010511 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" downshifts 1010491 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" misc_feature 1010548..1010567 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1010548 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" CDS 1010581..1011324 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" gene 1010581..1011324 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" downshifts 1011296 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" CDS complement(1011348..1012196) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" gene complement(1011348..1012196) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" downshifts complement(1011372) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" promotor_-35 1012192..1012197 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1012197..1012296) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 1012213..1012231 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1012215 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" S_feature 1012220..1012415 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(1012285..1012304) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1012299) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" promotor_-35 complement(1012319..1012322) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1012414..1012433 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1012417..1012480 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 1012417 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" CDS 1012481..1013329 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" gene 1012481..1013329 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" downshifts 1013320 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" CDS complement(1013372..1014733) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" gene complement(1013372..1014733) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" downshifts complement(1013396) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" S_feature complement(1014734..1014804) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(1014777..1014796) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1014804) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" CDS complement(1014860..1015360) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" gene complement(1014860..1015360) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" downshifts complement(1014892) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" promotor_-10 complement(1015382..1015400) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1015402) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" promotor_-35 complement(1015415..1015421) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1015439..1015446 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1015454..1015523 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 1015455 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" promotor_-10 1015461..1015480 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1015524..1015685 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" gene 1015524..1015685 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" downshifts 1015615 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" S_feature 1015686..1015804 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 1015805..1017562 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" gene 1015805..1017562 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" CDS 1017559..1019580 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" gene 1017559..1019580 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" downshifts 1019568 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" CDS complement(1019629..1020249) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" gene complement(1019629..1020249) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" downshifts complement(1019644) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" promotor_no_box 1020234..1020334 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1020263..1020282) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020278) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" CDS complement(1020288..1020413) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" gene complement(1020288..1020413) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" upshifts 1020294 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1020297..1020300) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1020427..1020446) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020436) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" promotor_-35 complement(1020460..1020469) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1020492 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" CDS complement(1020518..1020721) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" gene complement(1020518..1020721) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" downshifts complement(1020523) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" S_feature complement(1020722..1020832) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 1020762..1020862 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1020822 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1020838) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" promotor_-10 complement(1020842..1020853) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1020868..1020874) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1020930..1021148) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" gene complement(1020930..1021148) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" downshifts complement(1020964) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" promotor_-10 complement(1021189..1021208) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021206) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" promotor_-35 complement(1021222..1021229) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1021298..1022659) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" gene complement(1021298..1022659) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" downshifts complement(1021316) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" downshifts complement(1021360) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" CDS complement(1022649..1023740) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" gene complement(1022649..1023740) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" promotor_-10 complement(1023064..1023078) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023076) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1023092..1023100) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1023741..1023846) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(1023830..1023848) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023850) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" promotor_-35 complement(1023864..1023869) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1023912..1023919 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023934..1023953 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023945 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" CDS 1024007..1025140 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" gene 1024007..1025140 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" S_feature 1025141..1025232 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 1025233..1025586 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" gene 1025233..1025586 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" downshifts 1025574 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" CDS complement(1025630..1026703) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" gene complement(1025630..1026703) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" downshifts complement(1025737) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" promotor_-10 complement(1026725..1026744) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026737) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" promotor_-35 complement(1026758..1026765) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1026840..1026847 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1026860 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" promotor_-10 1026862..1026881 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1026871..1027024 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 1026981 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" S_feature 1027026..1027109 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 1027066 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" promotor_-35 1027122..1027127 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1027143..1027161 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1027152 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" CDS 1027189..1028055 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" gene 1027189..1028055 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" downshifts 1028037 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" promotor_-35 1028100..1028103 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1028118..1028137 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1028126 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" CDS 1028167..1029672 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" gene 1028167..1029672 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" downshifts 1029642 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" CDS complement(1029690..1030907) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" gene complement(1029690..1030907) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" downshifts complement(1029696) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" CDS complement(1030914..1031411) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" gene complement(1030914..1031411) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" CDS complement(1031475..1031813) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" gene complement(1031475..1031813) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" promotor_-10 complement(1031825..1031844) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1031849) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" promotor_-35 complement(1031858..1031865) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1031885..1031892 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031907..1031926 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031917 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" CDS 1031978..1032745 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" gene 1031978..1032745 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" downshifts 1032746 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" CDS complement(1032766..1032951) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" gene complement(1032766..1032951) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" promotor_-10 complement(1032987..1033005) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032998) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" promotor_-35 complement(1033016..1033024) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1033025..1033028 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1033043..1033062 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033053 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" CDS 1033078..1033974 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" gene 1033078..1033974 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" CDS 1033967..1035226 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" gene 1033967..1035226 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" downshifts 1035210 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" promotor_-35 1035274..1035281 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1035293..1035312 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1035298 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" CDS 1035333..1036559 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" gene 1035333..1036559 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" downshifts complement(1036034) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" CDS 1036564..1039455 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" gene 1036564..1039455 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" promotor_-35 1037845..1037850 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1037866..1037884 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1037872 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" promotor_-35 1039463..1039468 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1039483..1039502 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1039498 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" CDS 1039529..1040473 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" gene 1039529..1040473 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" downshifts 1040451 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" promotor_-35 1040532..1040537 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1040553..1040571 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1040556 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" CDS 1040598..1040810 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" gene 1040598..1040810 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" downshifts 1040803 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" downshifts complement(1040841) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" CDS complement(1040851..1041729) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" gene complement(1040851..1041729) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" downshifts complement(1041039) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" promotor_-10 complement(1041767..1041786) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1041791) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" promotor_-35 complement(1041800..1041807) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1041827..1041836 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1041848 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" promotor_-10 1041849..1041868 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1041885..1041899) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1041886) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1041889..1041975 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" gene 1041889..1041975 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" promotor_-35 complement(1041908..1041912) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1041976..1042227 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 1042100..1042186 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" gene 1042100..1042186 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" downshifts 1042184 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" S_feature complement(1042196..1042458) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 1042229..1042712 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(1042239) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1042451..1042470) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1042458) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" S_feature complement(1042460..1042528) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(1042484..1042489) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1042529..1043047) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" gene complement(1042529..1043047) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" promotor_-35 1042834..1042842 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1042854..1042872 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1042867 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1043078..1043097) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043096) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" promotor_-35 complement(1043113..1043119) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1043196..1043199 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043214..1043233 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043219 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" CDS 1043255..1043596 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" gene 1043255..1043596 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" S_feature complement(1043450..1043592) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(1043493) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" CDS complement(1043593..1044204) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" gene complement(1043593..1044204) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" S_feature 1043597..1044362 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(1043669) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" promotor_-35 1044200..1044204 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1044212..1044225 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1044224 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1044229..1044248) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(1044252) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" promotor_-35 complement(1044263..1044266) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 1044319 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" CDS complement(1044382..1044738) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" gene complement(1044382..1044738) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" downshifts complement(1044386) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" promotor_-35 1044815..1044820 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1044821..1044840) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1044835) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" promotor_-10 1044836..1044854 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1044836 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" S_feature complement(1044837..1045100) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 1044868..1045059 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" gene 1044868..1045059 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" S_feature 1045060..1046495 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(1045133..1045651) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" gene complement(1045133..1045651) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" downshifts complement(1045145) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" S_feature complement(1045652..1045739) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(1045731..1045750) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045739) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" promotor_-35 complement(1045764..1045771) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1045776..1046855) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" gene complement(1045776..1046855) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" misc_feature complement(1046894..1046913) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1046905) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" S_feature complement(1046907..1046988) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1047002..1047439) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" gene complement(1047002..1047439) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" downshifts complement(1047033) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" promotor_-10 complement(1047472..1047491) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047486) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" downshifts 1047489 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" promotor_-35 complement(1047505..1047512) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1047511..1047807) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1047554) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" promotor_-10 complement(1047805..1047816) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047811) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" promotor_-35 complement(1047831..1047837) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1047867..1047874 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1047888..1047907 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1047897 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" CDS 1047927..1048670 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" gene 1047927..1048670 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" CDS 1048663..1049889 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" gene 1048663..1049889 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" promotor_-10 complement(1049222..1049240) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1049237) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1049256..1049261) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1049909..1050619 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" gene 1049909..1050619 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" downshifts 1050583 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" CDS complement(1050637..1051827) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" gene complement(1050637..1051827) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" downshifts complement(1050647) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" downshifts complement(1050712) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" promotor_-10 complement(1051851..1051870) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1051872) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" promotor_-35 complement(1051884..1051889) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1051900..1053291) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" gene complement(1051900..1053291) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" promotor_-10 complement(1053302..1053321) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053307) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" promotor_-35 complement(1053334..1053343) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1053357..1053671) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" gene complement(1053357..1053671) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" CDS complement(1053716..1054216) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" gene complement(1053716..1054216) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" downshifts complement(1053743) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" promotor_-10 complement(1054229..1054248) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1054231..1054235 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1054250) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" promotor_-10 1054251..1054270 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1054252 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" promotor_-35 complement(1054265..1054266) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1054283..1054289 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1054304..1054315 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1054309 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" CDS 1054338..1056482 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" gene 1054338..1056482 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" promotor_-10 complement(1054382..1054393) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1054385) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1054407..1054413) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1056519..1056525 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1056539..1056558 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1056549 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" CDS 1056604..1057665 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" gene 1056604..1057665 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" CDS 1057737..1058669 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" gene 1057737..1058669 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" CDS 1058684..1060096 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" gene 1058684..1060096 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" downshifts 1058687 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" downshifts 1060073 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" promotor_-35 1060157..1060164 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1060178..1060197 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1060183 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" CDS 1060242..1060817 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" gene 1060242..1060817 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" promotor_-35 1060561..1060564 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1060579 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" promotor_-10 1060581..1060600 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1060818..1060887 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1060888..1063215 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" gene 1060888..1063215 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" downshifts 1063197 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" CDS complement(1063257..1064234) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" gene complement(1063257..1064234) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" downshifts complement(1063270) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" promotor_-10 complement(1064248..1064267) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1064266) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" promotor_-35 complement(1064281..1064287) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1064293..1064301 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1064312..1064330 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1064319 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" CDS 1064361..1065137 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" gene 1064361..1065137 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" S_feature complement(1064853..1065474) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1065138..1065509 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1065452..1065471) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065473) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" promotor_-35 complement(1065485..1065494) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1065487..1065494 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1065509..1065528 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1065511 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" CDS 1065550..1066590 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" gene 1065550..1066590 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" CDS 1066603..1067010 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" gene 1066603..1067010 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" downshifts 1066981 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" CDS complement(1067047..1068336) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" gene complement(1067047..1068336) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" downshifts complement(1067077) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" S_feature complement(1068337..1068437) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1068436..1068455) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1068437) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" S_feature complement(1068439..1068575) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1068470..1068476) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1068607..1068747) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" gene complement(1068607..1068747) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" downshifts complement(1068620) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" promotor_-10 complement(1068766..1068785) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1068785) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" promotor_-35 complement(1068798..1068805) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1068829..1068835 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068849..1068868 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068852 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" CDS 1068899..1069633 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" gene 1068899..1069633 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" CDS 1069646..1070641 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" gene 1069646..1070641 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" CDS 1070706..1071350 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" gene 1070706..1071350 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" downshifts 1071338 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" promotor_-35 1071378..1071381 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1071396..1071415 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1071403 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" CDS 1071467..1073008 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" gene 1071467..1073008 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" downshifts 1072988 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" CDS complement(1073047..1073442) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" gene complement(1073047..1073442) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" downshifts complement(1073064) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1073462..1073473) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1073466) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" promotor_-35 complement(1073488..1073494) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1073527..1073530 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1073538 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" promotor_-10 1073545..1073564 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1073591..1074871 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" gene 1073591..1074871 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" promotor_-10 complement(1074018..1074037) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1074032) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1074053..1074058) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1074858 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" downshifts complement(1074908) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" CDS complement(1074910..1076055) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" gene complement(1074910..1076055) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" S_feature complement(1076056..1076122) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1076111..1076130) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1076128) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" promotor_-35 complement(1076146..1076150) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1076435..1076442 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1076457..1076476 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1076459 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" CDS 1076490..1076939 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" gene 1076490..1076939 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" promotor_-35 1076955..1076962 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1076977..1076996 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1076984 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" CDS 1077011..1078003 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" gene 1077011..1078003 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" downshifts 1078004 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" S_feature 1078049..1078159 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1078137..1078144 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1078160..1078179 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1078161 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" CDS 1078220..1079191 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" gene 1078220..1079191 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" downshifts 1079170 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" CDS complement(1079223..1079804) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" gene complement(1079223..1079804) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" downshifts complement(1079246) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1079828..1079847) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1079840) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" promotor_-35 complement(1079863..1079866) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1079875..1080969) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" gene complement(1079875..1080969) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" CDS complement(1080966..1082405) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" gene complement(1080966..1082405) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" CDS complement(1082412..1082972) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" gene complement(1082412..1082972) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" misc_feature complement(1082422..1082441) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1082436) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" promotor_-10 complement(1082997..1083016) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1083011) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" promotor_-35 complement(1083031..1083038) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1083107..1084405) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" gene complement(1083107..1084405) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" downshifts complement(1083118) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1084459..1084477) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1084462) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" promotor_-35 complement(1084491..1084497) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1084544..1086073) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" gene complement(1084544..1086073) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" promotor_-10 complement(1086100..1086118) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1086110) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" promotor_-35 1086129..1086134 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1086133..1086138) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1086146 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" promotor_-10 1086150..1086168 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1086185..1087042 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" gene 1086185..1087042 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" downshifts 1087024 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" CDS complement(1087070..1087303) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" gene complement(1087070..1087303) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" downshifts complement(1087103) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" promotor_-10 complement(1087320..1087339) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1087323..1087324 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1087323 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" promotor_-10 1087327..1087342 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1087342) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" S_feature complement(1087344..1088199) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1087354..1087361) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1087526..1087533 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1087545..1087564 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1087551 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" CDS 1087596..1088174 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" gene 1087596..1088174 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" S_feature 1088175..1088320 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1088221..1089120) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" gene complement(1088221..1089120) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" downshifts complement(1088244) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" promotor_-35 1088307..1088310 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1088322 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1088328..1088332 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1088366 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" S_feature 1088411..1089277 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1089147..1089165) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1089164) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" promotor_-35 complement(1089180..1089186) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1089254..1089261 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1089276..1089295 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1089279 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" CDS 1089337..1089606 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" gene 1089337..1089606 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" downshifts 1089598 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" downshifts complement(1089646) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" CDS complement(1089649..1091118) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" gene complement(1089649..1091118) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" CDS complement(1091115..1091315) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" gene complement(1091115..1091315) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" S_feature complement(1091316..1091434) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1091417..1091436) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1091434) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" promotor_-35 complement(1091449..1091456) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1091522) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" CDS complement(1091523..1091885) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" gene complement(1091523..1091885) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" promotor_-35 1091723..1091728 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1091744..1091762 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1091745 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" S_feature 1091754..1091993 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1091915..1091934) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1091933) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" promotor_-35 complement(1091949..1091956) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1091975..1091982 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1091995 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" promotor_-10 1091996..1092015 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1092037..1092660 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" gene 1092037..1092660 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" CDS 1092662..1093168 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" gene 1092662..1093168 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" downshifts 1093161 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" promotor_-35 1093219..1093226 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1093240..1093259 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1093249..1093348 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1093249 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" CDS 1093349..1094848 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" gene 1093349..1094848 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" promotor_-35 1094856..1094863 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1094875 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" promotor_-10 1094877..1094896 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1094925..1095452 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" gene 1094925..1095452 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" downshifts 1095414 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" S_feature complement(1095466..1095609) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1095504) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" CDS complement(1095610..1096815) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" gene complement(1095610..1096815) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" promotor_-35 1096305..1096310 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1096327..1096345 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1096330..1096856 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1096331 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" downshifts 1096814 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" CDS complement(1096887..1097939) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" gene complement(1096887..1097939) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" CDS complement(1097953..1098801) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" gene complement(1097953..1098801) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" CDS complement(1098773..1100098) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" gene complement(1098773..1100098) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" promotor_-35 1098942..1098947 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1098963..1098981 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1098969..1099757 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1098969 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" promotor_-35 1099733..1099740 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1099755..1099774 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1099759..1100201 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1099759 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" promotor_-10 complement(1100133..1100152) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1100145) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" promotor_-35 complement(1100166..1100173) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1100202..1101191 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" gene 1100202..1101191 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" S_feature 1101192..1101569 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1101246..1101404) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1101289) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" CDS complement(1101405..1102559) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" gene complement(1101405..1102559) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" S_feature complement(1102560..1102631) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1102614..1102633) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102630) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" promotor_-35 complement(1102647..1102652) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1102666..1103871) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" gene complement(1102666..1103871) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" misc_feature 1103892..1103911 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1103897 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1103985..1105712 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" gene 1103985..1105712 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" promotor_-35 1105298..1105305 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1105320..1105339 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1105327 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1105742..1106068) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" gene complement(1105742..1106068) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" CDS complement(1106186..1106623) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" gene complement(1106186..1106623) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" downshifts complement(1106195) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" promotor_-10 complement(1106654..1106673) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1106674) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" promotor_-35 complement(1106686..1106695) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1106743..1106750 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1106764..1106783 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1106776 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" CDS 1106807..1110307 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" gene 1106807..1110307 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" CDS 1110294..1113992 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" gene 1110294..1113992 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" S_feature 1113993..1114063 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1114064..1115239 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " gene 1114064..1115239 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" CDS 1115236..1118628 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" gene 1115236..1118628 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" promotor_-35 1117883..1117889 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1117904..1117915 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1117911 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" S_feature complement(1117980..1118953) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1118642..1118944 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" gene 1118642..1118944 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" downshifts 1118924 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" CDS complement(1118981..1119199) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" gene complement(1118981..1119199) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" downshifts complement(1118998) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" CDS complement(1119231..1119632) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" gene complement(1119231..1119632) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" CDS complement(1119632..1119808) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" gene complement(1119632..1119808) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" CDS complement(1119805..1120422) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" gene complement(1119805..1120422) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" CDS complement(1120445..1120678) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" gene complement(1120445..1120678) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" CDS complement(1120693..1120914) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" gene complement(1120693..1120914) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" S_feature complement(1120915..1121001) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1120929..1120935 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1120949..1120968 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1120951..1121606 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1120951 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" promotor_-10 complement(1120988..1121007) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1121001) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" S_feature complement(1121003..1121132) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1121020..1121029) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1121134..1121336) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1121177) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" CDS complement(1121337..1121507) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" gene complement(1121337..1121507) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" misc_feature complement(1121551..1121570) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1121554) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" S_feature complement(1121556..1121652) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1121563 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" S_feature 1121608..1121772 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1121653..1122576) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" gene complement(1121653..1122576) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" promotor_-10 complement(1122598..1122617) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1122609) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" promotor_-35 complement(1122631..1122640) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1122660..1122668 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1122680..1122698 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1122685 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" CDS 1122731..1123636 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" gene 1122731..1123636 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" S_feature 1123637..1123717 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1123687..1123690 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1123707..1123726 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1123719 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" CDS 1123752..1124108 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" gene 1123752..1124108 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" downshifts 1124005 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" downshifts 1124096 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" upshifts 1124229 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" misc_feature 1124232..1124251 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1124276..1126960 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" gene 1124276..1126960 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" downshifts complement(1124444) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" downshifts 1126952 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" CDS complement(1126991..1127578) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" gene complement(1126991..1127578) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" promotor_-10 complement(1127593..1127612) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1127612) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" promotor_-35 complement(1127628..1127630) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1127633..1127639 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1127651 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" promotor_-10 1127654..1127672 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1127657..1127723 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1127724..1129568 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" gene 1127724..1129568 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" S_feature 1129569..1129636 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1129593 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" CDS complement(1129698..1130177) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " gene complement(1129698..1130177) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" upshifts complement(1130197) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" promotor_-10 complement(1130201..1130219) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1130230..1130238) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1130369..1130373 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1130386 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" promotor_-10 1130388..1130407 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1130409..1131233 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" gene 1130409..1131233 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" promotor_-35 1130621..1130627 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1130642..1130660 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1130649 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1131243..1132693 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1131263..1132630) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" gene complement(1131263..1132630) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" promotor_-35 1132662..1132669 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1132683..1132702 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1132695 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" CDS 1132754..1133617 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" gene 1132754..1133617 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" CDS 1133635..1134648 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" gene 1133635..1134648 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" downshifts 1134631 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" promotor_-35 1134700..1134707 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1134722..1134741 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1134741..1134856 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1134741 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" CDS 1134857..1135885 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" gene 1134857..1135885 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" downshifts 1135907 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" CDS complement(1135936..1136445) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" gene complement(1135936..1136445) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" downshifts complement(1135955) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" promotor_-10 complement(1136458..1136476) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1136474) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" promotor_-35 complement(1136488..1136496) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1136495..1137157) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" gene complement(1136495..1137157) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" promotor_-35 1137176..1137182 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1137196..1137215 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1137205 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" CDS 1137224..1138678 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" gene 1137224..1138678 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" S_feature complement(1138533..1138685) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1138568) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" CDS complement(1138686..1139324) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" gene complement(1138686..1139324) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" S_feature complement(1139325..1139459) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1139373..1139378 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1139394..1139412 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1139395 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" S_feature 1139405..1139529 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1139445..1139464) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1139459) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" promotor_-35 complement(1139479..1139486) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1139530..1140336 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" gene 1139530..1140336 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" downshifts 1140329 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" CDS complement(1140364..1140963) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" gene complement(1140364..1140963) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" downshifts complement(1140383) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" CDS complement(1140960..1142129) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" gene complement(1140960..1142129) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" S_feature complement(1142130..1142241) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1142242..1142952) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" gene complement(1142242..1142952) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" promotor_-10 complement(1142996..1143015) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1143018) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" promotor_-35 complement(1143028..1143037) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1143067..1143076 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1143090..1143109 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1143101 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" CDS 1143137..1143823 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" gene 1143137..1143823 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" CDS 1143820..1144578 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" gene 1143820..1144578 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" downshifts 1144575 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" CDS complement(1144623..1145252) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" gene complement(1144623..1145252) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" promotor_-10 complement(1145286..1145304) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1145303) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" promotor_-35 complement(1145319..1145324) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1145348..1146463) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" gene complement(1145348..1146463) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" downshifts complement(1145377) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" CDS complement(1146472..1147740) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" gene complement(1146472..1147740) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" promotor_-10 complement(1147766..1147777) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1147775) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" promotor_-35 complement(1147791..1147797) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1147852..1148700) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" gene complement(1147852..1148700) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" downshifts complement(1147863) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" CDS complement(1148705..1149154) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" gene complement(1148705..1149154) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" promotor_-10 complement(1149175..1149194) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1149189) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" promotor_-35 complement(1149210..1149211) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1149244..1151082) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" gene complement(1149244..1151082) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" downshifts complement(1149271) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" downshifts complement(1151164) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" misc_RNA complement(1151172..1151289) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(1151172..1151289) /gene="mswK" /locus_tag="BSU_misc_RNA_12" promotor_-10 complement(1151341..1151360) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1151355) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" promotor_-35 complement(1151375..1151382) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1151396..1151887) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" gene complement(1151396..1151887) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" promotor_-35 1151905..1151908 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1151911..1151930) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1151923..1151942 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1151924 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" upshifts complement(1151929) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" promotor_-35 complement(1151945..1151952) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1151986..1152882 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" gene 1151986..1152882 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" downshifts 1152869 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" CDS complement(1152935..1153519) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" gene complement(1152935..1153519) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" downshifts complement(1152945) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" CDS complement(1153516..1154445) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" gene complement(1153516..1154445) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" misc_feature complement(1153601) /Source="Nicolas_upshift_promotors" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1153603) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" CDS complement(1154430..1154966) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" gene complement(1154430..1154966) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" promotor_-10 complement(1155002..1155021) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155016) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" promotor_-35 complement(1155036..1155039) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1155107..1155114 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1155129..1155148 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1155132 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" CDS 1155144..1155491 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" gene 1155144..1155491 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" CDS 1155488..1156075 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" gene 1155488..1156075 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" CDS 1156095..1156388 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" gene 1156095..1156388 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" downshifts 1156368 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" downshifts 1156412 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" CDS 1156524..1158140 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" gene 1156524..1158140 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" downshifts 1158128 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" CDS complement(1158187..1159038) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" gene complement(1158187..1159038) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" downshifts complement(1158204) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" promotor_-35 1158585..1158592 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1158607..1158626 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1158612..1159137 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1158614 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" promotor_-10 complement(1159079..1159098) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1159102) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" promotor_-35 1159116..1159121 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1159118) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1159136..1159154 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1159139 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" CDS 1159176..1160018 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" gene 1159176..1160018 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" promotor_-35 1159671..1159679 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1159690..1159708 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1159690 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" S_feature 1160019..1160132 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1160133..1160492 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" gene 1160133..1160492 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" downshifts 1160481 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" CDS complement(1160523..1160720) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" gene complement(1160523..1160720) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" downshifts complement(1160536) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" S_feature complement(1160721..1160917) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1160917) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" promotor_-10 complement(1160919..1160930) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1160945..1160951) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1160977..1161789) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" gene complement(1160977..1161789) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" promotor_-10 complement(1161827..1161846) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1161847..1161854 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1161847) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" promotor_-35 complement(1161860..1161867) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1161866..1161885 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1161868 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" CDS 1161910..1162677 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" gene 1161910..1162677 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" promotor_-35 1162686..1162692 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1162706 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" promotor_-10 1162707..1162726 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1162741..1163049 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" gene 1162741..1163049 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" downshifts 1163034 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" S_feature 1163079..1163344 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1163345..1164775 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" gene 1163345..1164775 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" CDS 1164820..1165314 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" gene 1164820..1165314 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" downshifts 1165278 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" promotor_-35 1165452..1165459 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1165458 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" promotor_-10 1165473..1165492 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1165521..1166558 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" gene 1165521..1166558 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" CDS 1166578..1167798 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" gene 1166578..1167798 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" CDS 1167813..1168589 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" gene 1167813..1168589 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" CDS 1168586..1169743 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" gene 1168586..1169743 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" CDS 1169814..1170875 /gene="carA" /locus_tag="BSU_11230" /old_locus_tag="BSU11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGIVLSNGPGDPKAIQ PYLGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMT SQNHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEW IFDDYLKNVIPARREIAHA*" gene 1169814..1170875 /gene="carA" /locus_tag="BSU_11230" /old_locus_tag="BSU11230" misc_feature complement(1170709..1170728) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1170719) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1170868..1173960 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" gene 1170868..1173960 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" CDS 1173948..1174907 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" gene 1173948..1174907 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" downshifts 1174870 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" S_feature complement(1174910..1175184) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1174935..1174941 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1174943) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" promotor_-10 1174956..1174967 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174977 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" CDS 1174993..1175172 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" gene 1174993..1175172 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" downshifts 1175182 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" CDS complement(1175218..1175403) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" gene complement(1175218..1175403) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" downshifts complement(1175229) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" promotor_-10 complement(1175432..1175451) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1175449) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" promotor_-35 complement(1175462..1175469) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1175504..1175510 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1175522..1175541 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1175527 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1175584..1175593 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1175593 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" promotor_-10 1175606..1175625 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1175652..1176386 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" gene 1175652..1176386 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" S_feature complement(1176145..1176747) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1176367..1176372 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1176385 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" upshifts 1176385 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" promotor_-10 1176388..1176406 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1176468..1177025 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" gene 1176468..1177025 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" promotor_-10 complement(1176727..1176746) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1176747) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" promotor_-35 complement(1176761..1176765) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1177032..1177039 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1177054..1177073 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1177066 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" CDS 1177116..1178069 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" gene 1177116..1178069 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" promotor_-35 1177733..1177737 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1177753..1177772 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1177766 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" CDS 1178084..1178275 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" gene 1178084..1178275 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" downshifts 1178254 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" S_feature 1178299..1178639 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1178305..1178544) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" gene complement(1178305..1178544) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" downshifts complement(1178321) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" promotor_-10 complement(1178557..1178576) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1178578) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" promotor_-35 complement(1178590..1178599) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1178605..1178612 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178627..1178646 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1178641 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" CDS 1178709..1179647 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" gene 1178709..1179647 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" promotor_-35 1178786..1178795 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1178804 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" promotor_-10 1178807..1178822 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1179670..1180911 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" gene 1179670..1180911 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" promotor_-10 complement(1179884..1179902) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1179892) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1179918..1179923) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1180762 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" downshifts 1180895 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" promotor_-35 1180936..1180945 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1180958..1180977 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1180960 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" promotor_-35 1180972..1180980 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1180987..1181772 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" gene 1180987..1181772 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" promotor_-10 1180992..1181010 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1181004 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1181773..1181857 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1181789..1181807) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1181806) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1181822..1181827) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1181825..1181832 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1181847..1181866 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1181859..1181963 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1181859 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" CDS 1181964..1182950 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" gene 1181964..1182950 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" CDS 1182947..1183936 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" gene 1182947..1183936 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" misc_feature 1183942..1183948 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1183947..1184023 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1183947 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" CDS 1184024..1184515 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" gene 1184024..1184515 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo CDS 1184488..1185654 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" gene 1184488..1185654 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo downshifts 1185645 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" CDS 1185730..1186680 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" gene 1185730..1186680 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" CDS 1186697..1187608 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" gene 1186697..1187608 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" downshifts 1187622 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" S_feature 1187667..1187774 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1187747..1187752 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1187768..1187786 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1187776 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" CDS 1187813..1188565 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" gene 1187813..1188565 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" downshifts 1188545 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" CDS complement(1188600..1189592) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" gene complement(1188600..1189592) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" downshifts complement(1188621) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" misc_RNA complement(1189651..1189865) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" gene complement(1189651..1189865) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" downshifts complement(1189699) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" misc_feature complement(1189884..1189903) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1189897) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" promotor_-35 1190152..1190159 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1190173..1190335 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1190174..1190193 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1190174 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" CDS 1190336..1191973 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" gene 1190336..1191973 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" downshifts 1191867 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" S_feature 1191974..1192080 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1192081..1193016 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" gene 1192081..1193016 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" promotor_-10 complement(1192124..1192143) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1192141) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1192159..1192165) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1193020..1193937 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" gene 1193020..1193937 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" CDS 1193942..1195018 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" gene 1193942..1195018 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" CDS 1195020..1195937 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" gene 1195020..1195937 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" downshifts 1195907 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" promotor_-35 1195987..1195990 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1196003 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1196005..1196024 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1196044..1197261 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" gene 1196044..1197261 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" promotor_-35 1197314..1197323 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1197336..1197351 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1197345..1197424 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1197345 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" CDS 1197425..1198003 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" gene 1197425..1198003 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" S_feature 1198004..1198118 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1198055..1198074) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198059) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1198088..1198095) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1198121..1198134 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1198121 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" CDS 1198184..1198579 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" gene 1198184..1198579 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" promotor_no_box complement(1198415..1198515) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1198455) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1198577 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" S_feature 1198622..1199411 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1198622..1199278) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" gene complement(1198622..1199278) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" promotor_-10 complement(1199308..1199326) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1199323) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" promotor_-35 complement(1199341..1199346) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1199384..1199391 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199405..1199424 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1199413..1199554 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1199413 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" CDS 1199448..1199588 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" gene 1199448..1199588 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" CDS 1199555..1200211 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" gene 1199555..1200211 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" downshifts 1200201 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" CDS complement(1200206..1200328) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" gene complement(1200206..1200328) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" S_feature 1200246..1200335 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1200314..1200322 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200333..1200351 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1200337..1200401 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1200337 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" CDS 1200402..1201523 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" gene 1200402..1201523 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" promotor_-35 1201177..1201183 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1201195 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" promotor_-10 1201198..1201216 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1201409..1201417 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1201429..1201447 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1201436 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" promotor_-35 1201517..1201523 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201538..1201549 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201547 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" CDS 1201570..1203582 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" gene 1201570..1203582 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" promotor_-35 1201645..1201652 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1201667..1201686 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1201679 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" downshifts 1203529 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" S_feature 1203583..1203884 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1203620..1203787) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" gene complement(1203620..1203787) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" downshifts complement(1203633) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" promotor_-10 complement(1203807..1203825) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1203823) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" promotor_-35 complement(1203841..1203846) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1203877..1203884 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1203886..1204011 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1203886 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" misc_RNA 1203892..1204030 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" gene 1203892..1204030 /gene="roxS" /locus_tag="BSU_misc_RNA_67" promotor_-10 1203899..1203918 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1203968 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" CDS complement(1204101..1205000) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" gene complement(1204101..1205000) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" downshifts complement(1204132) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1204336..1204341 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1204348 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" promotor_-10 1204357..1204375 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1204364..1206265 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1204997..1205395) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" gene complement(1204997..1205395) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" S_feature complement(1205396..1205575) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1205567..1205586) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1205575) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" promotor_-35 complement(1205598..1205605) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1205650..1206195) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" gene complement(1205650..1206195) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" downshifts complement(1205674) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" S_feature complement(1206196..1206398) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1206399..1206971) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" gene complement(1206399..1206971) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" promotor_-10 complement(1206544..1206562) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1206553) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" promotor_-35 complement(1206575..1206582) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1207000..1207019) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1207017) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" promotor_-35 1207033..1207036 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1207034..1207041) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1207049 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" promotor_-10 1207052..1207071 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1207096..1207464 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" gene 1207096..1207464 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" CDS 1207493..1208128 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" gene 1207493..1208128 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" CDS 1208147..1208947 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" gene 1208147..1208947 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" CDS 1209010..1209861 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" gene 1209010..1209861 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" downshifts 1209820 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" CDS complement(1209874..1210608) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" gene complement(1209874..1210608) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" downshifts complement(1209896) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" promotor_-35 1210730..1210734 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1210751..1210770 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1210765 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" S_feature 1210766..1210842 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1210843..1212687 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" gene 1210843..1212687 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" misc_feature complement(1211170..1211189) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1211194) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1212689..1212696 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1212710..1212729 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1212716 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" misc_RNA 1212749..1212857 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 1212749..1212857 /gene="tswA" /locus_tag="BSU_misc_RNA_14" downshifts 1212852 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" CDS 1212936..1213646 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" gene 1212936..1213646 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" CDS 1213621..1214238 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" gene 1213621..1214238 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" CDS 1214222..1215331 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" gene 1214222..1215331 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" CDS 1215331..1215531 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" gene 1215331..1215531 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" CDS 1215528..1216298 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" gene 1215528..1216298 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" CDS 1216295..1217305 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" gene 1216295..1217305 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" CDS 1217324..1218139 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" gene 1217324..1218139 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" downshifts 1218113 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1218186..1218192 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1218205..1218224 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1218215 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" CDS 1218275..1219051 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" gene 1218275..1219051 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" downshifts 1219040 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" promotor_-35 1219099..1219104 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1219120..1219138 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1219124 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" promotor_-10 complement(1219136..1219150) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1219136) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1219152..1219835 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" gene 1219152..1219835 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" promotor_-35 complement(1219158..1219162) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1219830 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" downshifts 1219918 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" CDS complement(1219929..1220375) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" gene complement(1219929..1220375) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" downshifts complement(1219950) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" S_feature complement(1220376..1220502) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1220503..1220991) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" gene complement(1220503..1220991) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" promotor_-35 1220671..1220677 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1220692..1220711 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1220710 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1220987..1220991 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1221000..1221014 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1221018 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1221028..1221047) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1221045) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" promotor_-35 complement(1221061..1221070) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1221077..1221095) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1221094) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" promotor_-35 complement(1221111..1221116) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1221128 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" CDS complement(1221143..1221661) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" gene complement(1221143..1221661) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" downshifts complement(1221167) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" downshifts 1221172 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" S_feature complement(1221662..1221759) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1221760..1222077) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" gene complement(1221760..1222077) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" CDS complement(1222118..1222504) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" gene complement(1222118..1222504) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" promotor_-35 1222500..1222504 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1222512..1222526 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1222514 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1222524..1222543) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1222546) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" S_feature complement(1222548..1223052) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 complement(1222562) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1222601..1222606 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1222622..1222640 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1222624 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" CDS 1222664..1223020 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" gene 1222664..1223020 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" promotor_-35 1223030..1223039 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1223037..1223056) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1223045..1223278) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" gene complement(1223045..1223278) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo upshifts complement(1223052) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" S_feature 1223053..1223239 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1223053..1223070 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1223053 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" promotor_-35 complement(1223070..1223079) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1223096) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" downshifts 1223196 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" upshifts complement(1223250) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1223251..1223260 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1223258..1223265) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1223274..1223293 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1223284 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" CDS 1223302..1223508 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" gene 1223302..1223508 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" CDS 1223345..1223560 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" gene 1223345..1223560 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" promotor_-35 1223532..1223541 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1223554..1223573 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1223559 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" promotor_-10 complement(1223566..1223580) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1223580) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1223590..1223594) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1223590..1223739 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" gene 1223590..1223739 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" downshifts 1223680 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" S_feature 1223740..1223871 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1223872..1224126 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" gene 1223872..1224126 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" downshifts 1224111 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" downshifts complement(1224130) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" S_feature 1224156..1225256 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1224200..1226479) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" gene complement(1224200..1226479) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" downshifts complement(1224218) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" S_feature complement(1226354..1226528) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1226407..1226415 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1226426..1226444 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1226430..1226565 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1226430 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" promotor_-10 complement(1226516..1226535) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1226527) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" promotor_-35 1226543..1226549 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1226551..1226555) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1226564..1226582 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1226567 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" CDS 1226596..1226850 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" gene 1226596..1226850 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" downshifts 1226826 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" downshifts complement(1226916) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" CDS complement(1226923..1227345) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" gene complement(1226923..1227345) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" CDS complement(1227349..1227864) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" gene complement(1227349..1227864) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" CDS complement(1227901..1228623) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" gene complement(1227901..1228623) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" misc_feature complement(1228662..1228681) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1228683) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" promotor_-35 1228732..1228739 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1228754..1228773 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1228758 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" misc_RNA 1228791..1228911 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 1228791..1228911 /gene="mswA" /locus_tag="BSU_misc_RNA_15" downshifts 1228916 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" CDS 1228979..1230100 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" gene 1228979..1230100 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" CDS 1230093..1231265 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" gene 1230093..1231265 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" downshifts 1231248 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" misc_feature 1231282..1231300 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1231292 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" S_feature 1231293..1232822 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1231298..1231843) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" gene complement(1231298..1231843) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" downshifts complement(1231319) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" CDS complement(1231913..1233103) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" gene complement(1231913..1233103) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" promotor_-10 complement(1233129..1233148) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1233133) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" promotor_-35 complement(1233163..1233170) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1233197..1233204 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1233208 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" promotor_-10 1233218..1233237 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1233276..1233348 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 1233276..1233348 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" promotor_-10 complement(1233290..1233307) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1233304) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1233328..1233334) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1233338 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" S_feature complement(1233363..1234098) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1233383..1235031 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1233392) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" S_feature complement(1234100..1234188) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1234143) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" CDS complement(1234189..1235418) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" gene complement(1234189..1235418) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" downshifts complement(1234311) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" downshifts 1234988 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" S_feature complement(1235419..1235504) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1235459..1235466 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235481..1235500 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1235490..1235509) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235494 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" upshifts complement(1235508) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" promotor_-35 complement(1235522..1235528) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1235544..1235864 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" gene 1235544..1235864 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" downshifts 1235874 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" S_feature 1235919..1236016 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1236017..1236148 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " gene 1236017..1236148 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" CDS 1236164..1236337 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" gene 1236164..1236337 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" CDS 1236374..1236835 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" gene 1236374..1236835 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" promotor_-35 1236806..1236813 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1236828..1236847 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1236836..1237076 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1236836 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" promotor_-35 1237049..1237056 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1237070..1237088 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1237078 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" CDS 1237101..1237604 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" gene 1237101..1237604 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" CDS 1237616..1237900 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" gene 1237616..1237900 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" downshifts 1237870 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" upshifts complement(1237902) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1237913..1237916) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1238061..1238588 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" gene 1238061..1238588 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" promotor_-35 1238735..1238740 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1238753..1238772 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1238756 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" CDS 1238762..1239079 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" gene 1238762..1239079 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" S_feature 1239080..1239315 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1239316..1240071 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" gene 1239316..1240071 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" S_feature 1240072..1240159 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1240116 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" S_feature complement(1240159..1240219) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1240190) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" CDS complement(1240220..1240567) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" gene complement(1240220..1240567) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" promotor_-10 complement(1240599..1240617) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240612) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" S_feature complement(1240614..1241070) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1240628..1240636) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1241030..1241048 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1241042 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" promotor_-10 complement(1241048..1241067) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1241070) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" promotor_-35 complement(1241081..1241088) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1241118..1243064 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" gene 1241118..1243064 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" downshifts 1243040 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" promotor_-35 1243140..1243143 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1243159..1243178 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1243170 /Source="Nicolas_upshifts" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" upshifts complement(1243182) /Source="Nicolas_upshifts" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1243191..1243205) /Source="Nicolas_upshift_promotors" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1243212..1245164 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" /EC_number="2.7.1.191" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10627040, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627040, 10960106, 23551403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannose-specificenzyme IIBCA component" /protein_id="NP_389083.2" /db_xref="EnsemblGenomes-Gn:BSU12010" /db_xref="EnsemblGenomes-Tr:CAB13058" /db_xref="GOA:O31645" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R48" /db_xref="SubtiList:BG13176" /db_xref="UniProtKB/Swiss-Prot:O31645" /translation="MKLLAITSCPNGIAHTYMAAENLQKAADRLGVSIKVETQGGIGV ENKLTEEEIREADAIIIAADRSVNKDRFIGKKLLSVGVQDGIRKPEELIQKALNGDIP VYRSATKSESGNHQEKKQNPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGL VIPDDSFWKTIEQIGSASFSFMIPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYDS ASGAGFLGGIIAGFLAGYAALWIKKLKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIG APVAQIFASLTVWLAGMKGSSSILLALILGAMISFDMGGPVNKVAFLFGSAMIGEGNY EIMGPIAVAICIPPIGLGIATFLGKRKFEASQREMGKAAFTMGLFGITEGAIPFAAQD PLRVIPSIMAGSMTGSVIAMIGNVGDRVAHGGPIVAVLGAVDHVLMFFIAVIAGSLVT ALFVNVLKKDITASPVLSETAPTSAPSEAAAANEIKQPIQSQKAEMSEFKKLTDIISP ELIEPNLSGETSDDIIDELIQKLSRRGALLSESGFKQAILNREQQGTTAIGMNIAIPH GKSEAVREPSVAFGIKRSGVDWNSLDGSEAKLIFMIAVPKESGGNQHLKILQMLSRKL MDDNYRERLLSVQTTEEAYKLLEEIE*" gene 1243212..1245164 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" CDS 1245179..1246126 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 7934877, 20862359, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 7934877, 20862359, 23551403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6 phosphate isomerase; cupin family" /protein_id="NP_389084.1" /db_xref="EnsemblGenomes-Gn:BSU12020" /db_xref="EnsemblGenomes-Tr:CAB13059" /db_xref="GOA:O31646" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13177" /db_xref="UniProtKB/Swiss-Prot:O31646" /translation="MTTEPLFFKPVFKERIWGGTALADFGYTIPSQRTGECWAFAAHQ NGQSVVQNGMYKGFTLSELWEHHRHLFGQLEGDRFPLLTKILDADQDLSVQVHPNDEY ANIHENGELGKTECWYIIDCQKDAEIIYGHNATTKEELTTMIERGEWDELLRRVKVKP GDFFYVPSGTVHAIGKGILALETQQNSDTTYRLYDYDRKDAEGKLRELHLKKSIEVIE VPSIPERHTVHHEQIEDLLTTTLIECAYFSVGKWNLSGSASLKQQKPFLLISVIEGEG RMISGEYVYPFKKGDHMLLPYGLGEFKLEGYAECIVSHL*" gene 1245179..1246126 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" S_feature 1246127..1246225 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1246200..1246206 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1246221..1246240 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1246227..1246295 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1246227 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" CDS 1246296..1246778 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" gene 1246296..1246778 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" downshifts 1246758 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" CDS complement(1246824..1247330) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" gene complement(1246824..1247330) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" downshifts complement(1246848) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" misc_feature complement(1247355..1247374) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1247361) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" S_feature complement(1247363..1247548) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1247549..1247944) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" gene complement(1247549..1247944) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" promotor_-10 complement(1247967..1247985) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1247980) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" S_feature complement(1247982..1248682) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1248000..1248005) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1248088..1248095 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248109..1248128 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248120 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" CDS 1248173..1248652 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " gene 1248173..1248652 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" downshifts 1248651 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" CDS complement(1248692..1248886) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" gene complement(1248692..1248886) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" downshifts complement(1248727) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" promotor_-10 complement(1248900..1248915) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1248916) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" promotor_-35 complement(1248927..1248936) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1249052..1249381) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" gene complement(1249052..1249381) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" promotor_-10 complement(1249418..1249437) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1249431) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" S_feature complement(1249433..1250000) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1249452..1249457) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1249485..1249489 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1249505..1249524 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1249509..1250010 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1249509 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" CDS complement(1250001..1250990) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" gene complement(1250001..1250990) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" promotor_-10 complement(1250991..1251010) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1250994) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" promotor_-35 complement(1251024..1251029) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1251113..1251361) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" gene complement(1251113..1251361) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" downshifts complement(1251123) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" promotor_-35 1251357..1251361 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1251370..1251384 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1251379 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1251386..1251405) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1251395) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" promotor_-35 complement(1251419..1251428) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1251476..1251483 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1251490..1251509) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1251497..1251516 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1251499) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" upshifts 1251510 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" S_feature 1251511..1251614 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1251523..1251530) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1251615..1253018 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" gene 1251615..1253018 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" downshifts 1253007 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" CDS complement(1253058..1253531) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" gene complement(1253058..1253531) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" downshifts complement(1253062) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1253553..1253571) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253571) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" promotor_-35 complement(1253586..1253591) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1253656..1253823) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" gene complement(1253656..1253823) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" downshifts complement(1253659) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" promotor_-10 complement(1253835..1253853) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253844) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" promotor_-35 complement(1253866..1253873) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1253950..1254849 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" gene 1253950..1254849 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" CDS complement(1254858..1255256) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" gene complement(1254858..1255256) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" downshifts complement(1254888) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" promotor_-10 complement(1255285..1255304) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1255304) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" promotor_-35 complement(1255319..1255326) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1255357..1255932) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" gene complement(1255357..1255932) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" downshifts complement(1255372) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" promotor_-10 complement(1255951..1255969) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1255966) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" promotor_-35 complement(1255983..1255989) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1256007..1256013 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1256028..1256046 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1256029 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" CDS 1256078..1259035 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" gene 1256078..1259035 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" CDS 1259028..1259588 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" gene 1259028..1259588 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" downshifts 1259581 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" S_feature 1259626..1259744 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1259722..1259725 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1259741..1259760 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1259746 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" CDS 1259785..1260426 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" gene 1259785..1260426 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" downshifts complement(1259794) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" downshifts 1260399 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" CDS 1260505..1261131 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" gene 1260505..1261131 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" downshifts 1261133 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" downshifts complement(1261136) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" CDS complement(1261162..1261440) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" gene complement(1261162..1261440) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" downshifts complement(1261180) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1261469..1261480) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1261482..1261488) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1261488) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" S_feature complement(1261490..1261906) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1261658 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" misc_feature 1261659..1261678 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1261676..1261830 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1261831..1263021 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" gene 1261831..1263021 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" promotor_-10 complement(1261904..1261923) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261906) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" promotor_-35 complement(1261937..1261946) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1263044..1264222 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" gene 1263044..1264222 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" CDS complement(1264263..1264451) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" gene complement(1264263..1264451) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" downshifts complement(1264279) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(1264477..1264496) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1264480) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" promotor_-35 complement(1264510..1264516) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1264538..1264545 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1264560..1264579 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1264571 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" promotor_-10 complement(1264586..1264605) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1264590) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1264620..1264627) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1264625..1265437 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" gene 1264625..1265437 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" downshifts 1265416 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" CDS complement(1265483..1266235) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" gene complement(1265483..1266235) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" downshifts complement(1265492) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" CDS complement(1266235..1266987) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" gene complement(1266235..1266987) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" CDS complement(1267107..1268081) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" gene complement(1267107..1268081) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" downshifts complement(1267142) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1268102..1268121) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1268128) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" S_feature complement(1268130..1270636) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1268136..1268143) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1268164..1268170 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268185..1268203 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1268188 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" CDS 1268213..1268710 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" gene 1268213..1268710 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" S_feature 1268711..1268824 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1268804..1268808 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268824..1268843 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1268826..1269098 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1268826 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" CDS 1269099..1269521 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" gene 1269099..1269521 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" CDS 1269561..1270739 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" gene 1269561..1270739 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" promotor_no_box 1270570..1270670 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1270628..1270646) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1270630 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1270636) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" promotor_-35 complement(1270658..1270666) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1270738 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" promotor_-35 1270847..1270854 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1270869..1270888 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1270894 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" CDS 1270937..1272358 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" gene 1270937..1272358 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" CDS 1272426..1273805 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" gene 1272426..1273805 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" promotor_-10 complement(1272945..1272964) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1272950) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1272978..1272985) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1273830 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" misc_feature 1273840..1273847 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1273842..1273909 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1273910..1274923 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" gene 1273910..1274923 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" CDS 1274929..1275948 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" gene 1274929..1275948 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" CDS 1275973..1277052 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" gene 1275973..1277052 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" CDS 1277049..1277885 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" gene 1277049..1277885 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" CDS 1277933..1279201 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" gene 1277933..1279201 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" promotor_-35 1279145..1279148 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279164..1279168 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1279166 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" misc_feature 1279234..1279253 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1279234 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" CDS 1279289..1280290 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " gene 1279289..1280290 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" promotor_no_box complement(1279972..1280072) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1280012) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1280266 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" CDS 1280367..1281809 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" gene 1280367..1281809 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" CDS 1281806..1283299 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" gene 1281806..1283299 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" CDS complement(1283338..1284102) /gene="yjnA" /locus_tag="BSU_12400" /old_locus_tag="BSU12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGSIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" gene complement(1283338..1284102) /gene="yjnA" /locus_tag="BSU_12400" /old_locus_tag="BSU12400" downshifts complement(1283357) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" SCAR join(1284129,1284136) /created_by="User" /modified_by="User" /label="TF8A" N_region 1284130..1284135 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1284138..1284458 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1284138..1284458 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1284467 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" S_feature complement(1284476..1284679) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1284495..1284632) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" gene complement(1284495..1284632) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" downshifts complement(1284519) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" CDS complement(1284718..1284888) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" gene complement(1284718..1284888) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" downshifts complement(1284724) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" CDS complement(1284888..1285634) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" gene complement(1284888..1285634) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" promotor_-10 complement(1285469..1285488) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1285486) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" promotor_-35 complement(1285504..1285511) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1285660..1285678) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1285673) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" promotor_-35 complement(1285694..1285699) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1285744..1286745) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " gene complement(1285744..1286745) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" downshifts complement(1285773) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" CDS complement(1286758..1287375) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" gene complement(1286758..1287375) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" promotor_-10 complement(1287411..1287430) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287413) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" S_feature complement(1287415..1287512) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1287446..1287450) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1287492..1287511) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287512) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" promotor_-35 complement(1287526..1287533) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1287557..1287576) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1287569) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" CDS complement(1287651..1288967) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" gene complement(1287651..1288967) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" downshifts complement(1287666) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1289014..1289033) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1289030) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" promotor_-35 complement(1289048..1289051) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1289250..1289257 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289272..1289291 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1289284..1289355 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1289284 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" CDS 1289356..1290306 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" gene 1289356..1290306 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" downshifts 1290294 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" CDS 1290407..1290553 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" gene 1290407..1290553 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" CDS 1290561..1292711 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" gene 1290561..1292711 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" promotor_no_box 1291450..1291550 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1291510 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1291598 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" CDS 1292723..1293694 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" gene 1292723..1293694 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" S_feature complement(1293051..1293692) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1293737) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" S_feature complement(1293762..1294128) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1293805) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" promotor_-10 complement(1294108..1294123) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294128) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" promotor_-35 complement(1294135..1294144) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1294212..1295561) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " gene complement(1294212..1295561) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" downshifts complement(1294226) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" promotor_-35 1295601..1295608 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1295613..1295632) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1295621 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" promotor_-10 1295623..1295642 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1295631) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" S_feature complement(1295633..1295715) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1295643..1295650) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1295672..1295678 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1295693..1295712 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1295696 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" promotor_-10 complement(1295698..1295717) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1295715) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" CDS 1295730..1296548 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" gene 1295730..1296548 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" promotor_-35 complement(1295733..1295736) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1296526 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" promotor_-35 1296605..1296612 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1296627..1296646 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1296631 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" CDS 1296677..1297501 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" gene 1296677..1297501 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" CDS 1297518..1298444 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" gene 1297518..1298444 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" CDS 1298450..1299412 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" gene 1298450..1299412 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" promotor_-35 1299144..1299149 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1299165..1299183 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1299166 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" CDS 1299417..1300424 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" gene 1299417..1300424 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" CDS 1300427..1302076 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" gene 1300427..1302076 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" downshifts 1302070 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" CDS 1302164..1303123 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" gene 1302164..1303123 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" CDS 1303120..1304220 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" gene 1303120..1304220 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" CDS 1304217..1305107 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" gene 1304217..1305107 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" CDS 1305120..1306109 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" gene 1305120..1306109 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" S_feature complement(1305403..1306130) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1306099 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" S_feature 1306144..1307312 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1306152..1307201) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" gene complement(1306152..1307201) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" downshifts complement(1306175) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1307228..1307247) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1307239) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" promotor_-35 complement(1307262..1307269) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1307291..1308151) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" gene complement(1307291..1308151) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" promotor_-10 complement(1308176..1308194) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1308193) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" promotor_-35 complement(1308210..1308216) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1308225..1308232 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308246..1308265 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308253 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" CDS 1308311..1308829 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" gene 1308311..1308829 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" downshifts 1308820 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" promotor_-35 1308894..1308900 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1308912..1309018 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1308912 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" promotor_-10 1308914..1308925 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1308993..1308996 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1309012..1309031 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1309020 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" CDS 1309068..1310267 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" gene 1309068..1310267 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" downshifts 1310256 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" S_feature 1310301..1310672 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1310344..1310568) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" gene complement(1310344..1310568) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" promotor_-35 1310648..1310654 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310668..1310679 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1310674 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" CDS 1310713..1311444 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" gene 1310713..1311444 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" downshifts 1311422 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" promotor_-35 1311483..1311491 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311502..1311520 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1311510 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" CDS 1311536..1312063 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" gene 1311536..1312063 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" CDS 1312053..1312571 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" gene 1312053..1312571 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" promotor_-35 1312565..1312572 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1312586..1312605 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1312589 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" misc_RNA 1312604..1312715 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" gene 1312604..1312715 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" downshifts 1312678 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" CDS 1312793..1313131 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" gene 1312793..1313131 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" CDS 1313131..1313448 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" gene 1313131..1313448 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" promotor_-35 1313448..1313451 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1313467..1313486 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1313479 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" CDS 1313519..1314421 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" gene 1313519..1314421 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" downshifts 1314412 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" promotor_-35 1314468..1314474 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1314480 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" promotor_-10 1314488..1314507 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1314509..1314719 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" gene 1314509..1314719 /gene="pswB" /locus_tag="BSU_misc_RNA_17" downshifts 1314677 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" CDS 1314772..1315869 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" gene 1314772..1315869 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" promotor_-35 1314959..1314961 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1314963..1314967 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1314963 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" CDS 1315881..1317128 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" gene 1315881..1317128 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" downshifts 1317119 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" promotor_-35 1317190..1317197 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1317212..1317231 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1317221 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" CDS 1317254..1317679 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" gene 1317254..1317679 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" downshifts 1317668 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" CDS complement(1317710..1318153) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" gene complement(1317710..1318153) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" downshifts complement(1317744) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(1318180..1318199) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1318186) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" promotor_-35 complement(1318214..1318217) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1318235..1318241 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1318255..1318273 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1318261 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" CDS 1318296..1318706 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" gene 1318296..1318706 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" downshifts 1318684 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" CDS 1318733..1318903 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" gene 1318733..1318903 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" S_feature 1318904..1319581 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1318953..1319423) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" gene complement(1318953..1319423) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" downshifts complement(1318977) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1319445..1319464) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319461) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" S_feature complement(1319463..1319570) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1319480..1319483) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1319539 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" CDS complement(1319596..1321884) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" gene complement(1319596..1321884) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" downshifts complement(1319615) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" S_feature complement(1321885..1321947) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1321907..1322007) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1321947) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" misc_RNA complement(1322012..1322167) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" gene complement(1322012..1322167) /gene="mswB" /locus_tag="BSU_misc_RNA_18" downshifts complement(1322013) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(1322200..1322219) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322212) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" S_feature complement(1322214..1322299) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1322235..1322242) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1322300..1323259) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" gene complement(1322300..1323259) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" S_feature complement(1323260..1323311) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1323304..1323323) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323316) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" promotor_-35 complement(1323337..1323343) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1323428..1323431 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1323444 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" promotor_-10 1323447..1323466 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1323482..1324315 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" gene 1323482..1324315 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" downshifts 1324291 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" CDS complement(1324346..1325110) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" gene complement(1324346..1325110) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" downshifts complement(1324367) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" CDS complement(1325085..1326728) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" gene complement(1325085..1326728) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" CDS complement(1326715..1327314) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" gene complement(1326715..1327314) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" CDS complement(1327316..1327918) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" gene complement(1327316..1327918) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" downshifts complement(1327996) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" misc_RNA complement(1328015..1328127) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene complement(1328015..1328127) /gene="tswB" /locus_tag="BSU_misc_RNA_19" promotor_-35 1328128..1328131 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1328142..1328161) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1328147..1328166 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328158 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1328163) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" promotor_-35 complement(1328176..1328183) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1328229..1328915 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" gene 1328229..1328915 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" CDS 1328919..1330283 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" gene 1328919..1330283 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" CDS 1330280..1330960 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" gene 1330280..1330960 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" promotor_-35 1330989..1330994 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1331010..1331028 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1331013 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" CDS 1331052..1331564 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" gene 1331052..1331564 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" downshifts 1331550 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" promotor_-35 1331595..1331601 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1331615..1331626 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1331616 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" CDS 1331647..1331784 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" gene 1331647..1331784 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" downshifts 1331757 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" promotor_-35 1331843..1331850 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1331864..1331883 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1331866..1332185 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1331866 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" misc_RNA 1331898..1332051 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" gene 1331898..1332051 /gene="swmG" /locus_tag="BSU_misc_RNA_68" promotor_-35 1332163..1332172 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1332185..1332204 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1332187..1332288 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1332187 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" CDS 1332289..1333644 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" gene 1332289..1333644 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" downshifts 1333635 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" CDS complement(1333687..1334019) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" gene complement(1333687..1334019) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" promotor_-10 complement(1334035..1334054) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1334045) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" S_feature complement(1334047..1334435) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1334070..1334075) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1334107..1334207 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1334167 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" CDS 1334214..1334369 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" gene 1334214..1334369 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" promotor_-35 1334378..1334385 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1334392..1334409 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1334409 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" promotor_-10 complement(1334420..1334439) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1334435) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" promotor_-35 complement(1334453..1334459) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1334457..1334639 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" gene 1334457..1334639 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" downshifts 1334607 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" promotor_-35 1334664..1334672 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1334683..1334701 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1334689..1334771 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1334689 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" CDS 1334772..1335236 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" gene 1334772..1335236 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" downshifts 1335221 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" CDS complement(1335251..1336372) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" gene complement(1335251..1336372) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" promotor_-35 1335660..1335668 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1335682..1335701 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1335685..1336463 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1335685 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" promotor_-10 complement(1336401..1336412) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1336421) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1336427..1336433) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1336464..1337015 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" gene 1336464..1337015 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" downshifts 1336983 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" CDS complement(1337043..1337855) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" gene complement(1337043..1337855) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" promotor_-10 complement(1337815..1337834) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337829) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1337848..1337853) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1337956..1337962 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1337973..1338047 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1337973 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" promotor_-10 1337976..1337987 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1338048..1339742 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" gene 1338048..1339742 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" CDS 1339755..1340768 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" gene 1339755..1340768 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" downshifts 1340753 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" CDS complement(1340794..1342629) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" gene complement(1340794..1342629) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" downshifts complement(1340843) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" CDS complement(1342633..1343568) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" gene complement(1342633..1343568) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" promotor_-10 complement(1343539..1343550) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1343549) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" promotor_-35 complement(1343565..1343571) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1343605..1346007) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" gene complement(1343605..1346007) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" downshifts complement(1343637) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" S_feature complement(1345855..1346057) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1346046..1346064) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1346057) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" promotor_-35 complement(1346078..1346085) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1346124..1346131 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1346145..1346164 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1346157 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" CDS 1346188..1346853 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" gene 1346188..1346853 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" promotor_-10 complement(1346722..1346741) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1346739) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1346755..1346764) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1346848..1346855 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1346870..1346889 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1346883 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" misc_RNA 1346909..1347042 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" gene 1346909..1347042 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" CDS 1346930..1347904 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" gene 1346930..1347904 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" downshifts 1346993 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" downshifts 1347892 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" promotor_-35 1348014..1348022 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1348036..1348044 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1348046 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" S_feature 1348049..1348135 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1348108..1348115 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1348129..1348148 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1348137 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" CDS 1348168..1348923 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" gene 1348168..1348923 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" CDS 1348920..1350065 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" gene 1348920..1350065 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" S_feature 1350066..1351225 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1350076..1350270) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" gene complement(1350076..1350270) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" downshifts complement(1350083) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1350313..1350324) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1350323) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" promotor_-35 complement(1350339..1350345) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1350401..1351102) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" gene complement(1350401..1351102) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" downshifts complement(1350435) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" S_feature complement(1351103..1351183) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1351175..1351194) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1351183) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" promotor_-35 1351199..1351206 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1351208..1351215) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1351220..1351239 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1351227 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" CDS 1351273..1352169 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" gene 1351273..1352169 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" downshifts 1352163 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" promotor_-35 1352274..1352278 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1352294..1352313 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1352298 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" CDS 1352343..1353692 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " gene 1352343..1353692 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" downshifts 1353680 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1353741..1353747 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1353761..1353772 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1353769..1353836 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1353769 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" CDS 1353837..1353992 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" gene 1353837..1353992 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" CDS 1353995..1354171 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" gene 1353995..1354171 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" promotor_no_box 1354061..1354161 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1354121 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1354167 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" CDS complement(1354214..1355236) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" gene complement(1354214..1355236) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" downshifts complement(1354237) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" promotor_-10 complement(1355281..1355300) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1355297) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" promotor_-35 complement(1355312..1355318) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1355425..1355433 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1355441 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" promotor_-10 1355444..1355462 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1355489..1357705 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" gene 1355489..1357705 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" S_feature complement(1357480..1358420) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1357558..1357565 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1357580..1357599 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1357582 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" CDS 1357702..1358199 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" gene 1357702..1358199 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" S_feature 1358200..1358439 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1358289..1358414 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" gene 1358289..1358414 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" downshifts 1358407 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" CDS complement(1358448..1359509) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" gene complement(1358448..1359509) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" downshifts complement(1358465) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" CDS complement(1359517..1360710) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" gene complement(1359517..1360710) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" downshifts 1359577 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" downshifts complement(1360797) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" misc_RNA complement(1360803..1360959) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" gene complement(1360803..1360959) /gene="mswC" /locus_tag="BSU_misc_RNA_20" promotor_-10 complement(1360994..1361013) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360995) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" promotor_-35 complement(1361029..1361036) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1361039..1361042 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1361043..1361822) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" gene complement(1361043..1361822) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" promotor_-10 1361058..1361077 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361067 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1361515..1361522 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1361535..1361554 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1361550 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" S_feature 1361557..1361874 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1361844..1361851 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1361852..1361871) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1361866..1361885 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1361866) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" upshifts 1361876 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" promotor_-35 complement(1361887..1361894) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1361917..1363113 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" gene 1361917..1363113 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" promotor_-35 1363095..1363102 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363117..1363136 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363136 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" misc_RNA 1363152..1363252 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" gene 1363152..1363252 /gene="mswD" /locus_tag="BSU_misc_RNA_21" downshifts 1363251 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" CDS 1363337..1364554 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" gene 1363337..1364554 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" CDS 1364551..1365258 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" gene 1364551..1365258 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" CDS 1365216..1365845 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" gene 1365216..1365845 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" CDS 1365860..1366396 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" gene 1365860..1366396 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" S_feature complement(1366243..1366436) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1366396 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" CDS complement(1366437..1366757) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" gene complement(1366437..1366757) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" downshifts complement(1366495) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" S_feature complement(1366758..1366847) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1366783..1366789 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1366804..1366822 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1366814 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" S_feature 1366815..1366899 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1366829..1366848) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1366846) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" promotor_-35 complement(1366863..1366866) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1366873..1366880 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1366895..1366914 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1366901..1366959 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1366901 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" downshifts complement(1366957) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" CDS 1366960..1367217 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" gene 1366960..1367217 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" downshifts 1367211 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" CDS 1367303..1367734 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" gene 1367303..1367734 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" CDS complement(1367762..1369282) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" gene complement(1367762..1369282) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" downshifts complement(1367774) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" promotor_-35 1368483..1368489 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1368503..1368514 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1368509 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1369290..1369309) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1369311) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" promotor_-35 1369409..1369416 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369431..1369450 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369433 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" CDS 1369475..1369912 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" gene 1369475..1369912 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" downshifts 1369895 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" CDS complement(1369952..1370737) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" gene complement(1369952..1370737) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" downshifts complement(1369971) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" downshifts complement(1370433) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" CDS complement(1370709..1371521) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" gene complement(1370709..1371521) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" promotor_-10 complement(1371552..1371570) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1371568) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" promotor_-35 complement(1371584..1371591) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1371659..1371881) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1371691) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" CDS complement(1371904..1374003) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" gene complement(1371904..1374003) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" downshifts complement(1371926) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" S_feature complement(1374004..1374254) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1374214..1374314) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1374254) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" promotor_-35 1374290..1374295 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1374305 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" promotor_-10 1374311..1374329 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1374368..1375411 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" gene 1374368..1375411 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" S_feature 1375412..1375503 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1375480..1375484 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1375501..1375520 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1375505 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" misc_RNA 1375550..1375594 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" gene 1375550..1375594 /gene="qswA" /locus_tag="BSU_misc_RNA_22" downshifts 1375571 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" S_feature 1375616..1375723 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1375724..1376383 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" gene 1375724..1376383 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" CDS 1376376..1376825 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" gene 1376376..1376825 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" CDS 1376818..1377549 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" gene 1376818..1377549 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" CDS 1377567..1378064 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" gene 1377567..1378064 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" S_feature 1378065..1378341 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1378299 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" downshifts complement(1378309) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" S_feature complement(1378378..1378622) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1378419) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" CDS complement(1378623..1378979) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" gene complement(1378623..1378979) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" misc_feature complement(1379010..1379029) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1379027) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" promotor_-35 1379045 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1379064..1379082 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1379069 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" CDS 1379148..1379894 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" gene 1379148..1379894 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" downshifts 1379949 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" promotor_-35 1380297..1380305 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380319..1380338 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380323 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" CDS 1380375..1381574 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" gene 1380375..1381574 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" promotor_-35 1380457..1380463 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380478..1380496 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380484 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" promotor_-35 1381543..1381545 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1381565..1381583 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1381577 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" CDS 1381590..1381817 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" gene 1381590..1381817 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" misc_feature complement(1381667..1381686) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1381675) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1381818..1381913 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1381914..1382612 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" gene 1381914..1382612 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo S_feature complement(1382565..1383391) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1382593..1382844 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" gene 1382593..1382844 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo misc_feature 1383094..1383109 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1383117..1383328 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1383117 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" downshifts 1383293 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1383380..1383399) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1383402) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" promotor_-35 complement(1383415..1383422) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1383467..1383474 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1383489..1383508 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1383491 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" CDS 1383527..1383817 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" gene 1383527..1383817 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" S_feature complement(1383854..1383937) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1383897) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" CDS complement(1383938..1384123) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" gene complement(1383938..1384123) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" promotor_-10 complement(1384156..1384175) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1384167) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" S_feature complement(1384169..1384513) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1384189..1384196) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1384222..1384227 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1384243..1384262 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1384250 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" CDS 1384289..1384483 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" gene 1384289..1384483 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" downshifts 1384459 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" promotor_-10 complement(1384504..1384522) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1384520) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" promotor_-35 complement(1384539..1384544) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1384782..1385408 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" gene 1384782..1385408 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" downshifts 1385339 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" promotor_-35 1385465..1385470 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1385477 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" promotor_-10 1385486..1385504 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1385526..1386863 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" gene 1385526..1386863 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" CDS 1386914..1387411 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" gene 1386914..1387411 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" promotor_-35 1387260..1387266 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1387275 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1387281..1387299 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1387385 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" promotor_-35 1387506..1387512 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1387523..1387542 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1387535 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" S_feature 1387539..1387646 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1387647..1389560 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" gene 1387647..1389560 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" promotor_-10 complement(1387796..1387815) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387813) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1387828..1387837) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1387964..1387983) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387989) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1387997..1388003) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1389541 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" downshifts complement(1389617) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1389828..1389847) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389837) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1389861..1389868) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1389912..1389931 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1389922 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" CDS 1389967..1391058 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" gene 1389967..1391058 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" downshifts 1390707 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" downshifts 1391037 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" S_feature complement(1391071..1391289) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1391082..1391339 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1391276..1391295) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1391289) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" promotor_-35 complement(1391311..1391318) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1391340..1392305 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" gene 1391340..1392305 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" promotor_-35 1392323..1392330 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1392345..1392364 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1392357 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" CDS 1392368..1393234 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" gene 1392368..1393234 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" promotor_-35 1393089..1393093 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393110..1393129 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393118 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" downshifts 1393236 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" misc_RNA 1393281..1393432 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" S_feature 1393281..1393432 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1393281..1393432 /gene="gswA" /locus_tag="BSU_misc_RNA_88" promotor_-35 1393410..1393416 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393430..1393441 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393434 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" CDS 1393463..1395562 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" gene 1393463..1395562 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" promotor_-35 1395580..1395584 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395600..1395619 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1395611 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" CDS 1395660..1395926 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" gene 1395660..1395926 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" CDS 1395926..1397638 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" gene 1395926..1397638 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" downshifts 1397625 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" promotor_-35 1397678..1397684 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1397699..1397710 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1397702 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" CDS 1397729..1397968 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" gene 1397729..1397968 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" S_feature complement(1397749..1399088) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1398046..1399074 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" gene 1398046..1399074 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" downshifts 1399044 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" CDS complement(1399089..1399769) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" gene complement(1399089..1399769) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" promotor_-10 complement(1399779..1399798) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1399802) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" promotor_-35 complement(1399813..1399820) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1399854..1399861 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1399875..1399893 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1399881 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" CDS 1399904..1401871 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" gene 1399904..1401871 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" misc_feature complement(1400344..1400359) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1400356) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1401842 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1401915..1401917 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1401933..1401952 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1401943 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" downshifts complement(1401985) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" CDS 1402009..1402875 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" gene 1402009..1402875 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" downshifts 1402855 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" CDS complement(1402914..1403687) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" gene complement(1402914..1403687) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" downshifts complement(1402931) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1403719..1403738) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1403729) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" misc_feature 1403962..1403981 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1403975 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" S_feature 1403977..1404080 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1404024..1406138 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" gene 1404024..1406138 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" promotor_-10 complement(1405317..1405335) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1405329) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1405351..1405356) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1406119 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" promotor_-35 1406211..1406219 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1406231..1406249 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1406243 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" CDS 1406302..1408122 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" gene 1406302..1408122 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" CDS complement(1408133..1409314) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" gene complement(1408133..1409314) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" downshifts complement(1408167) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1409342..1409361) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1409358) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" promotor_-10 complement(1409390..1409408) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409402) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" S_feature complement(1409404..1409472) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1409423..1409428) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1409466..1409485) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1409472) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" CDS complement(1409516..1409677) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" gene complement(1409516..1409677) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" promotor_-10 complement(1409700..1409719) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409713) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" promotor_-35 complement(1409733..1409740) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1409814..1409821 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1409833 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" promotor_-10 1409834..1409852 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1409881..1410792 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" gene 1409881..1410792 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" downshifts complement(1409886) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" promotor_-35 1410335..1410343 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1410357..1410374 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1410360 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1410777 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" CDS complement(1410836..1411300) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" gene complement(1410836..1411300) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" downshifts complement(1410854) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1411330..1411349) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1411340) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" promotor_-35 complement(1411364..1411371) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1411426..1412718) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" gene complement(1411426..1412718) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" downshifts complement(1411448) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1412742..1412761) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1412746) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" promotor_-35 complement(1412777..1412781) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1412794..1413288) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" gene complement(1412794..1413288) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" promotor_-10 complement(1413304..1413323) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1413320) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" promotor_-35 complement(1413337..1413346) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1413345..1414205) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" gene complement(1413345..1414205) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" misc_feature complement(1414226..1414245) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1414239) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" promotor_-35 1414276..1414283 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1414299..1414318 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1414312 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" CDS 1414348..1415112 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" gene 1414348..1415112 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" S_feature 1415113..1415261 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1415242..1415260 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1415263..1415412 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1415263 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" downshifts complement(1415310) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" CDS 1415413..1417143 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" gene 1415413..1417143 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" CDS 1417209..1417727 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" gene 1417209..1417727 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" downshifts 1417725 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" promotor_-35 1417770..1417775 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417788..1417807 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1417791 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" CDS 1417823..1418371 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" gene 1417823..1418371 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" S_feature 1418372..1418523 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1418524..1419747 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" gene 1418524..1419747 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" promotor_-10 complement(1419710..1419728) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1419720) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1419726 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" promotor_-35 complement(1419743..1419748) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1419796..1419803 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1419815..1419916 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1419815 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" promotor_-10 1419818..1419837 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1419833..1419916 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" gene 1419833..1419916 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" downshifts 1419873 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" promotor_-35 1419927..1419932 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1419947..1420231 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1419947 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" promotor_-10 1419949..1419967 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1420208..1420214 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1420228..1420239 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1420233..1420320 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1420233 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" misc_feature 1420309..1420328 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1420322 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" CDS 1420393..1420632 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" gene 1420393..1420632 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" S_feature 1420633..1420741 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1420742..1421260 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" gene 1420742..1421260 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" promotor_-35 1421297..1421304 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1421318..1421337 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1421332 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" CDS 1421394..1421591 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" gene 1421394..1421591 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" downshifts 1421587 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" S_feature 1421632..1421728 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1421729..1422172 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" gene 1421729..1422172 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" S_feature 1422173..1422280 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1422248..1422253 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1422268..1422287 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1422282 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" CDS 1422321..1423202 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" gene 1422321..1423202 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" downshifts 1423181 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" promotor_-35 1423237..1423244 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1423259..1423278 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1423264 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" CDS 1423314..1423790 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" gene 1423314..1423790 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" CDS 1423780..1424673 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" gene 1423780..1424673 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" CDS 1424689..1425144 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" gene 1424689..1425144 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" promotor_-10 complement(1424960..1424979) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1424973) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1424993..1425001) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1425138 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" promotor_-35 1425183..1425190 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1425204..1425223 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1425205 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" CDS 1425249..1425959 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" gene 1425249..1425959 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" downshifts complement(1425258) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1425368..1425372) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1425368) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1425390) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1426029..1427153 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" gene 1426029..1427153 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" promotor_-35 1427165..1427171 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1427185..1427196 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1427187 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" promotor_-10 complement(1427191..1427205) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1427215..1427219) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1427215..1427460 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" gene 1427215..1427460 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" upshifts complement(1427216) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1427448 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" S_feature 1427493..1428443 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1427497..1428300) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" gene complement(1427497..1428300) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" downshifts complement(1427509) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(1428351..1428370) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428360) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" promotor_-35 complement(1428384..1428391) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1428416..1428423 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1428438..1428457 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1428445..1428536 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1428445 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" CDS 1428537..1429079 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" gene 1428537..1429079 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" CDS 1429151..1429597 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" gene 1429151..1429597 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" downshifts 1429605 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" promotor_-35 1429990..1429997 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1430010 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" promotor_-10 1430012..1430031 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1430063..1430638 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" gene 1430063..1430638 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" downshifts 1430616 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" CDS complement(1430679..1431644) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" gene complement(1430679..1431644) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" downshifts complement(1430692) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" promotor_-35 1430988..1430989 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1431007..1431026 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1431013..1431737 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1431013 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" promotor_-10 complement(1431665..1431683) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1431686) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" promotor_-35 complement(1431698..1431703) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1431724..1431730 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1431740 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" promotor_-10 1431744..1431763 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1431781..1432380 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" gene 1431781..1432380 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" CDS 1432431..1433450 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" gene 1432431..1433450 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" CDS 1433468..1434760 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" gene 1433468..1434760 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" CDS 1434721..1435242 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" gene 1434721..1435242 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" CDS 1435242..1435715 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" gene 1435242..1435715 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" CDS 1435708..1435941 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" gene 1435708..1435941 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" downshifts 1435920 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" promotor_-35 1435986..1435991 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1436008..1436026 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1436016 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" S_feature 1436028..1436114 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1436104..1436107 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1436116 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1436122..1436141 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1436165..1437922 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" gene 1436165..1437922 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" CDS 1437934..1439748 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" gene 1437934..1439748 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" promotor_-10 complement(1438371..1438390) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1438381) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1438405..1438412) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1439799..1439808 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439820..1439835 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439824 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" CDS 1439858..1440553 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" gene 1439858..1440553 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" CDS 1440558..1441691 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" gene 1440558..1441691 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" CDS 1441692..1442384 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" gene 1441692..1442384 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" CDS 1442381..1443574 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" gene 1442381..1443574 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" downshifts 1443552 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" promotor_-35 1443623..1443629 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1443643..1443654 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1443651 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" promotor_-35 1443696..1443703 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1443718..1443737 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1443723..1443814 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1443723 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" promotor_-35 1443778..1443785 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1443799..1443818 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1443816 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" CDS 1443854..1444609 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" gene 1443854..1444609 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" upshifts complement(1444002) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1444004..1444006) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1444024) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1444606..1445517 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" gene 1444606..1445517 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" CDS 1445532..1447439 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" gene 1445532..1447439 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" downshifts 1447424 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" promotor_-35 1447508..1447515 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1447526..1447545 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1447529 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" CDS 1447584..1448165 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" gene 1447584..1448165 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" downshifts 1448150 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" downshifts 1448194 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" CDS complement(1448199..1448468) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" gene complement(1448199..1448468) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" downshifts complement(1448204) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" S_feature complement(1448469..1448534) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1448515..1448534) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1448534) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" promotor_-35 1448587..1448594 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1448605..1448624 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1448609 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" CDS 1448649..1450271 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" gene 1448649..1450271 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" downshifts 1450259 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" CDS 1450328..1451239 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" gene 1450328..1451239 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" downshifts 1451244 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" CDS complement(1451273..1452505) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" gene complement(1451273..1452505) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" downshifts complement(1451284) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1452523..1452542) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1452547) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" promotor_-35 complement(1452557..1452562) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1452615..1452749) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" gene complement(1452615..1452749) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" downshifts complement(1452626) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1452771..1452789) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1452782) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" S_feature complement(1452784..1452849) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1452805..1452810) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1452850..1453857) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" gene complement(1452850..1453857) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" upshifts complement(1453903) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" promotor_-10 complement(1453904..1453912) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1453926..1453934) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1454044..1454053 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1454065 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" promotor_-10 1454066..1454081 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1454068..1454140 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1454141..1454419 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" gene 1454141..1454419 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" downshifts 1454417 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" S_feature complement(1454451..1456080) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1454462..1454566 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1454474) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" promotor_-35 1454548..1454555 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1454567..1454586 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1454568 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" CDS 1454609..1455895 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" gene 1454609..1455895 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" CDS 1455911..1456744 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" gene 1455911..1456744 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" promotor_-10 complement(1456077..1456095) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1456092) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" promotor_-35 complement(1456111..1456116) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1456807..1457472 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" gene 1456807..1457472 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" downshifts 1457456 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" promotor_-35 1457563..1457569 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1457584..1457603) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1457584..1457603 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1457596 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" upshifts complement(1457598) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1457627..1459360 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" gene 1457627..1459360 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" S_feature complement(1458755..1459359) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1459349 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" CDS complement(1459394..1461061) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" gene complement(1459394..1461061) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" downshifts complement(1459404) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" CDS complement(1461067..1461276) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" gene complement(1461067..1461276) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" promotor_-10 complement(1461313..1461332) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461335) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" S_feature complement(1461337..1461514) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1461347..1461350) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1461515) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" promotor_-10 complement(1461517..1461528) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1461542..1461548) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1461587..1461594 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1461608..1461627 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1461624 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" CDS 1461662..1462435 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" gene 1461662..1462435 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" downshifts 1462406 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" CDS complement(1462471..1463025) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" gene complement(1462471..1463025) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" downshifts complement(1462482) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1463047..1463066) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1463057) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" promotor_-35 complement(1463081..1463088) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1463110 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" downshifts complement(1463134) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" CDS complement(1463135..1463293) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" gene complement(1463135..1463293) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" CDS complement(1463200..1463343) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" gene complement(1463200..1463343) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" promotor_-35 1463289..1463293 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1463294..1463362) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1463303..1463317 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1463330 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1463346..1463365) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1463375) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" promotor_-35 complement(1463378..1463387) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1463449..1463456 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1463470..1463489 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1463474 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" CDS 1463507..1464178 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" gene 1463507..1464178 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" promotor_-35 1463846..1463855 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1463868..1463886 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1463880 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1464125 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" promotor_-35 1464353..1464358 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1464375..1464394 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1464376..1464601 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1464376 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" misc_feature complement(1464380..1464399) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1464396) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1464500..1464508) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1464506) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1464522..1464530) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1464602..1465717 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" gene 1464602..1465717 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" CDS 1465721..1466698 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" gene 1465721..1466698 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" S_feature 1466699..1466812 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1466733..1466752) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1466750) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1466767..1466770) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1466813..1468141 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" gene 1466813..1468141 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" promotor_-35 1466957..1466964 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1466979..1466998 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1466982 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" CDS 1468146..1469558 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" gene 1468146..1469558 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" downshifts 1469555 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" CDS complement(1469603..1469977) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" gene complement(1469603..1469977) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" downshifts complement(1469651) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" misc_feature complement(1470008..1470027) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1470018) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" promotor_-35 1470181..1470186 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1470202..1470220 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1470212 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" S_feature 1470216..1470325 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1470248) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" promotor_-35 1470309..1470316 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1470327 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" promotor_-10 1470331..1470350 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1470346..1470556 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" gene 1470346..1470556 /gene="srrA" /locus_tag="BSU_misc_RNA_70" CDS 1470396..1470515 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" gene 1470396..1470515 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" downshifts complement(1470402) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" downshifts 1470502 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" S_feature 1470547..1472150 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1470555..1472027) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" gene complement(1470555..1472027) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" downshifts complement(1470573) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" S_feature complement(1472028..1472123) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1472106..1472125) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1472123) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" promotor_-35 1472130..1472133 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1472140..1472147) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1472148..1472167 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1472152 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" CDS 1472212..1472478 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" gene 1472212..1472478 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" downshifts 1472460 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" CDS complement(1472511..1473149) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" gene complement(1472511..1473149) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" downshifts complement(1472536) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(1473170..1473189) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1473194) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" promotor_-35 complement(1473204..1473208) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1473219..1473225 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1473240..1473258 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1473241 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" promotor_-35 1473279..1473288 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1473301..1473320 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1473305..1473388 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1473305 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" CDS 1473389..1473577 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" gene 1473389..1473577 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" downshifts complement(1473394) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" downshifts 1473570 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" upshifts complement(1473592) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1473600..1473603) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1473647..1473650 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1473667..1473686 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1473670 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" CDS 1473717..1474514 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" gene 1473717..1474514 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" CDS 1474540..1474968 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" gene 1474540..1474968 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" downshifts 1474925 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" S_feature 1474969..1475922 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1475044) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" CDS complement(1475046..1475960) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" gene complement(1475046..1475960) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" promotor_-10 complement(1476026..1476045) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1476034) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" promotor_-35 complement(1476060..1476067) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1476312..1477877) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" gene complement(1476312..1477877) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" promotor_-10 complement(1477912..1477931) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1477923) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" promotor_-35 complement(1477945..1477952) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1478162..1480102 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" gene 1478162..1480102 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" CDS 1480092..1480361 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" gene 1480092..1480361 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" promotor_-35 1480327..1480331 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1480345..1480364 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1480358 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" CDS 1480361..1480882 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" gene 1480361..1480882 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" CDS 1480879..1481172 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" gene 1480879..1481172 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" CDS complement(1481212..1481823) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" gene complement(1481212..1481823) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" downshifts complement(1481226) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1481855..1481874) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1481864) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" promotor_-35 complement(1481889..1481892) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1482079) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" CDS complement(1482096..1482284) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" gene complement(1482096..1482284) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" downshifts complement(1482150) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1482306..1482325) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1482323) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" promotor_-35 complement(1482338..1482345) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1482351..1482370 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1482358 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" CDS 1482397..1484235 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" gene 1482397..1484235 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" CDS 1484292..1484609 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" gene 1484292..1484609 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" downshifts 1484583 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" downshifts complement(1484658) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" CDS complement(1484665..1484874) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" gene complement(1484665..1484874) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" misc_feature complement(1484888..1484907) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1484903) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" CDS complement(1484957..1485586) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" gene complement(1484957..1485586) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" downshifts complement(1484988) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1485488..1485506) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1485494) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1485518..1485526) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1485621..1485632) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1485626) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" promotor_-35 1485638..1485643 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1485647..1485653) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1485659..1485677 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1485659 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" S_feature 1485660..1485740 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1485741..1487069 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" gene 1485741..1487069 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" S_feature complement(1486925..1487072) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1486968) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" S_feature 1487070..1487660 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1487073..1487558) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" gene complement(1487073..1487558) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" promotor_-10 complement(1487570..1487589) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1487598) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" promotor_-35 complement(1487604..1487611) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1487661..1488590 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" gene 1487661..1488590 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" misc_feature 1488175..1488194 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1488184 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" promotor_-35 1488614..1488617 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1488632..1488651 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1488640 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" CDS 1488688..1488969 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" gene 1488688..1488969 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" downshifts 1488958 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" promotor_-35 1489032..1489035 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1489048..1489174 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1489048 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" promotor_-10 1489053..1489059 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1489175..1490386 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" gene 1489175..1490386 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" promotor_-35 1490396..1490400 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1490415..1490434 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1490434 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" CDS 1490461..1493907 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" gene 1490461..1493907 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" promotor_-10 complement(1493473..1493491) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1493493) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1493507..1493512) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1493887 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" downshifts 1493932 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" downshifts complement(1493964) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" downshifts 1493976 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" CDS complement(1494310..1495230) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" gene complement(1494310..1495230) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" downshifts complement(1494316) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(1495270..1495289) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1495285) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" promotor_-35 complement(1495303..1495310) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1495365..1495372 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1495386..1495405 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1495387..1495492 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1495387 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" S_feature 1495494..1495584 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1495494 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" promotor_-35 1495500..1495503 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1495518..1495534 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1495585..1496502 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" gene 1495585..1496502 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" downshifts 1496531 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" upshifts 1496550 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" misc_feature 1496551..1496556 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1496610..1496615 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1496630..1496648 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1496638..1496741 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1496638 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" CDS 1496742..1497812 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" gene 1496742..1497812 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" CDS 1497845..1499713 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" gene 1497845..1499713 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" CDS 1499713..1500336 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" gene 1499713..1500336 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" CDS 1500339..1500671 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" gene 1500339..1500671 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" CDS 1500698..1501591 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" gene 1500698..1501591 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" downshifts 1501566 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" CDS complement(1501623..1501985) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" gene complement(1501623..1501985) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" downshifts complement(1501642) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" promotor_-35 1501978..1501982 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1501991..1502004 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1502009..1502028) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1502013..1502124 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1502013 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" upshifts complement(1502021) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" promotor_-35 complement(1502043..1502050) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1502125..1502571 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" gene 1502125..1502571 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" promotor_-35 1502157..1502164 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1502176..1502195 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1502181 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" promotor_-35 1502580..1502587 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1502601..1502620 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1502612 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" CDS 1502655..1503695 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" gene 1502655..1503695 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" promotor_-10 complement(1503618..1503636) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1503623) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1503652..1503657) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1503675 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" promotor_-35 1503859..1503868 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1503882..1503901 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1503896 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" CDS 1503927..1504325 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" gene 1503927..1504325 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" downshifts complement(1503931) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" CDS 1504341..1504580 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" gene 1504341..1504580 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" downshifts 1504559 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" promotor_-35 1504647..1504654 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1504665..1504684 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1504670 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" CDS 1504696..1505145 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" gene 1504696..1505145 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" downshifts 1505131 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" CDS 1505200..1505472 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" gene 1505200..1505472 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" S_feature complement(1505277..1505500) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1505475..1505595 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" gene 1505475..1505595 /gene="csfG" /locus_tag="BSU_misc_RNA_23" S_feature complement(1505502..1505625) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1505545) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" S_feature 1505596..1505701 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1505626..1505638) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1505633) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" promotor_-35 complement(1505653..1505659) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1505682..1505686 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1505702..1505721 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1505703..1505794 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1505703 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" CDS 1505795..1506349 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" gene 1505795..1506349 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" CDS 1506354..1506839 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" gene 1506354..1506839 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" downshifts 1506806 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" CDS complement(1506850..1508076) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" gene complement(1506850..1508076) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" S_feature 1506851..1508125 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1508077..1508178) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1508100..1508107 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1508119..1508138 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1508127..1508256 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1508127 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" promotor_-10 complement(1508173..1508191) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1508188) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" promotor_-35 complement(1508208..1508213) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1508257..1509039 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" gene 1508257..1509039 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" promotor_-35 1508819..1508825 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1508839..1508850 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1508850 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" CDS 1509041..1510066 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" gene 1509041..1510066 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" downshifts 1509950 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" CDS complement(1510083..1511330) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" gene complement(1510083..1511330) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" downshifts complement(1510110) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" promotor_-35 1511247..1511253 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1511267..1511278 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1511271 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" CDS complement(1511327..1511512) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" gene complement(1511327..1511512) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" promotor_-35 1511345..1511349 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1511365..1511384 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1511374..1511509 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1511374 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" promotor_-10 complement(1511403..1511422) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1511413) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" promotor_-35 complement(1511436..1511443) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1511480..1511487 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1511501..1511520 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1511511 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" CDS 1511540..1512058 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" gene 1511540..1512058 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" CDS 1512080..1512259 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" gene 1512080..1512259 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" downshifts 1512239 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" upshifts complement(1512282) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1512286..1512289) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1512340..1512345 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1512361..1512379 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1512362 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" CDS 1512405..1512986 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" gene 1512405..1512986 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" downshifts 1512987 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" CDS complement(1513043..1513525) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" gene complement(1513043..1513525) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" downshifts complement(1513062) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" downshifts 1513515 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" promotor_-10 complement(1513548..1513567) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1513567) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" promotor_-35 complement(1513581..1513588) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1513625..1513631 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1513643..1513662 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1513645 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" CDS 1513685..1514581 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" gene 1513685..1514581 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" CDS 1514652..1516271 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" gene 1514652..1516271 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" downshifts 1516243 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" promotor_-35 1516305..1516308 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1516323..1516396 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1516323..1516342 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1516323 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" downshifts complement(1516380) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" CDS 1516397..1516828 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" gene 1516397..1516828 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" CDS 1516898..1517833 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" gene 1516898..1517833 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" S_feature complement(1517500..1518952) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1517873..1518226 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" gene 1517873..1518226 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" CDS 1518223..1520373 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" gene 1518223..1520373 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" promotor_-10 complement(1518933..1518951) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1518952) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" promotor_-35 complement(1518966..1518972) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1520356 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1520428..1520433 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1520449..1520467 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1520449 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" CDS 1520490..1522430 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" gene 1520490..1522430 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" promotor_-35 1522226..1522232 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1522247..1522255 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1522253 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" downshifts 1522403 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" S_feature 1522448..1522515 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1522485..1522489 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1522505..1522524 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1522517..1522605 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1522517 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" CDS 1522606..1524090 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" gene 1522606..1524090 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" S_feature 1524091..1524201 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1524202..1525176 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" gene 1524202..1525176 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" CDS 1525177..1526532 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" gene 1525177..1526532 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" promotor_-35 1526356..1526361 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1526377..1526395 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1526387 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" CDS 1526593..1527693 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" gene 1526593..1527693 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" S_feature 1527694..1527815 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1527816..1528907 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" gene 1527816..1528907 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" promotor_-35 1528296..1528305 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1528318..1528333 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1528323 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" promotor_no_box 1528329..1528429 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1528389 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" CDS 1528939..1529850 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" gene 1528939..1529850 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" downshifts 1529868 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" CDS 1529980..1530771 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" gene 1529980..1530771 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" CDS 1530768..1531463 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" gene 1530768..1531463 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" CDS 1531486..1532193 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" gene 1531486..1532193 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" CDS 1532211..1532576 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" gene 1532211..1532576 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" promotor_-35 1532428..1532431 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1532447..1532466 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1532463 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" S_feature 1532577..1532749 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1532750..1534072 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" gene 1532750..1534072 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" upshifts complement(1532957) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1532961..1532965) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1532980..1532984) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1534108..1535256 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" gene 1534108..1535256 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" downshifts 1535230 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" S_feature 1535455..1535558 /Source="Nicolas_S_feature" /locus_tag="new_1599179_1599282" /HighExp="T5.0H, BC, T4.0H, T3.30H, T3.0H, S2, BT, M9-stat, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.953" /TUlongSig="SigA, SigWXY, SigA, Sig-" /TUlongPSig="0.989, 1, 1, 0.436" /label="S561" upshifts 1535455 /Source="Nicolas_upshifts" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" misc_feature 1535457..1535476 /Source="Nicolas_upshift_promotors" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1535559..1539860 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillopeptidase F" /protein_id="NP_389413.1" /db_xref="EnsemblGenomes-Gn:BSU15300" /db_xref="EnsemblGenomes-Tr:CAB13403" /db_xref="GOA:P16397" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR008757" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR012103" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR033857" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10233" /db_xref="UniProtKB/Swiss-Prot:P16397" /translation="MRKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQ SAESIQNKISSSLKKSFKKKEKTTFLIKFKDLANPEKAAKAAVKKAKSKKLSAAKTEY QKRSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKV VQFPEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDG TGTVVASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGT HVTGTMVGSEPDGTNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGNP HPEMAPDVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANP ANYPESFATGATDINKKLADFSLQGPSPYDEIKPEISAPGVNIRSSVPGQTYEDGWDG TSMAGPHVSAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNA FDAVSAVTDGLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTS VKLSYKLDQGEWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSD VYDVTVKPSITAGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLT GNYANSANMNLVMPPIKAPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGV YNGKTSSWTDEEIDLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKK NKLGVEKPSGKQKKKPVNPKKAKPSANTAVKHQNKAIQPQVLPLKAQVSVVETGKSTY SDQSTGQYTLKHKAGDYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGT VINKTTGEPVTGASVYVVEDAAVEPAMTNDKGEYMLEAYEGAYTIKVAAPGYYSDEFS VELKGDVTKETALKPFVGYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGML TGGLFRFWDTEFPDPGGTEFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLS SKGIMVDKDFYLVYIQSKPDPYSPGLAMDETGQNSGRNWQYIDGKWQPGDKADGNYMI RALVDYEAAVPEITSPTDKSYTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGT FHAGIILNKGENELTATASTDNGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETL TVKGAVSDDNLKDVKVNGKKATVADGSYSARILLENGRNEIKVIATDLAGNKTTKKTV IDVNFDKPVISGLIPGEDKNLKAGESVKIAFSSAEDLDATFTIRMPLTNARASVQNAT ELPLREISPGRYEGYWTATSSIKAKGAKVEVIVRDDYGNETRKTANGKLNMNTEN*" gene 1535559..1539860 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" downshifts 1539857 /Source="Nicolas_upshifts" /id="D865" /incds=0 /nref=73 /ntot=169 /MaxReadThrough="0.90839" /MaxDrop="8.78054" /score="38.0577497" /energy="-11.4" /TU="NA" /idTUdmin="U1273" /TUdmin=1 /isTUend="TRUE" S_feature complement(1539868..1541010) /Source="Nicolas_S_feature" /locus_tag="new_1603592_1604734_c" /HighExp="S8, S6, S7, S5, LoTm, S4, B36, T5.0H, BT, B60" /AntisenseName="spoIIGA" /AntisenseCor="0.71080549463714104" /AntisenseRegPval="-42" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.579" /TUlongSig="NA" /TUlongPSig="NA" /label="S562" downshifts complement(1539910) /Source="Nicolas_upshifts" /id="D866" /incds=0 /nref=5 /ntot=22 /MaxReadThrough="2.36451" /MaxDrop="3.61596" /score="22.1321546" /energy="-9.6" /TU="NA" /idTUdmin="U1275" /TUdmin=0 /isTUend="TRUE" S_feature 1539988..1540054 /Source="Nicolas_S_feature" /locus_tag="new_1603712_1603778" /HighExp="M9-stat, T5.0H, S4, LoTm, T3.30H, T3.0H, B60, S3, S5, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S563" upshifts 1539990 /Source="Nicolas_upshifts" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" misc_feature 1539991..1540010 /Source="Nicolas_upshift_promotors" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature complement(1540008..1540020) /Source="Nicolas_upshift_promotors" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1540020) /Source="Nicolas_upshifts" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1540055..1540984 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease processing pro-sigma-E" /protein_id="NP_389414.1" /db_xref="EnsemblGenomes-Gn:BSU15310" /db_xref="EnsemblGenomes-Tr:CAB13405" /db_xref="GOA:P13801" /db_xref="InterPro:IPR005081" /db_xref="SubtiList:BG10234" /db_xref="UniProtKB/Swiss-Prot:P13801" /translation="MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGS SIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGI IGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQ YEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIR NTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKC LIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS*" gene 1540055..1540984 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" promotor_-10 complement(1540999..1541018) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1541012) /Source="Nicolas_upshifts" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" promotor_-35 complement(1541033..1541036) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1541047..1541766 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1581961, 7708009, 8464402, 15187183, 20802044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1581961, 7708009, 8464402, 15187183, 20802044; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-29 factor (sigma-E)" /protein_id="NP_389415.2" /db_xref="EnsemblGenomes-Gn:BSU15320" /db_xref="EnsemblGenomes-Tr:CAB13406" /db_xref="GOA:P06222" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014200" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG10235" /db_xref="UniProtKB/Swiss-Prot:P06222" /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEE QVLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTF NPEKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTD DDIITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQS YISRLEKRIIKRLRKEFNKMV*" gene 1541047..1541766 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" S_feature 1541767..1541856 /Source="Nicolas_S_feature" /locus_tag="new_1605491_1605580" /HighExp="T5.0H, S3, M9-stat, T4.0H, S4, LoTm, S2, B60, B36, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S564" promotor_-35 1541840..1541846 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1541858 /Source="Nicolas_upshifts" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" promotor_-10 1541860..1541871 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1541906..1542688 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15187183, 15256570, 16166546, 16497325, 17015665, 21935351" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187183, 15256570, 16166546, 16497325, 17015665, 21935351; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-G)" /protein_id="NP_389416.1" /db_xref="EnsemblGenomes-Gn:BSU15330" /db_xref="EnsemblGenomes-Tr:CAB13407" /db_xref="GOA:P19940" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014212" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10236" /db_xref="UniProtKB/Swiss-Prot:P19940" /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLV NGNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGE IRRYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFA LDAIQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMI LRKRFFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ*" gene 1541906..1542688 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" S_feature 1542689..1542777 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1542742..1542749 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1542762..1542781 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1542779 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" CDS 1542836..1543630 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" gene 1542836..1543630 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" promotor_-35 1543548..1543551 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1543566..1543585 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1543574 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" misc_RNA 1543643..1543744 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 1543643..1543744 /gene="tswE" /locus_tag="BSU_misc_RNA_24" downshifts 1543731 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" CDS 1543832..1545112 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" gene 1543832..1545112 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" misc_feature complement(1545053..1545069) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1545058) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1545133..1545138 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1545154..1545172 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1545158 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" CDS 1545195..1545440 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" gene 1545195..1545440 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" promotor_-35 1545356..1545364 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1545375..1545393 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1545383 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" S_feature 1545441..1545551 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1545543..1545562 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1545553 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" CDS 1545603..1546439 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" gene 1545603..1546439 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" CDS 1546446..1547138 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" gene 1546446..1547138 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" CDS 1547135..1547590 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" gene 1547135..1547590 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" CDS 1547597..1547869 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" gene 1547597..1547869 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" downshifts 1547858 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" CDS 1547930..1548703 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" gene 1547930..1548703 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" promotor_-35 1548419..1548426 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1548440..1548458 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1548463 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" S_feature 1548704..1548796 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1548797..1549291 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" gene 1548797..1549291 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" promotor_-35 1549304..1549311 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1549325..1549344 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1549332 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" misc_RNA 1549354..1549580 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" gene 1549354..1549580 /gene="iswA" /locus_tag="BSU_misc_RNA_25" downshifts 1549547 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" CDS 1549633..1552398 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" gene 1549633..1552398 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" downshifts 1552389 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" downshifts complement(1552444) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" promotor_-35 1552479..1552485 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1552500..1552511 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1552500 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" CDS 1552543..1552917 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" gene 1552543..1552917 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" promotor_-35 1552949..1552953 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1552968 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" promotor_-10 1552969..1552988 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1553020..1553484 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" gene 1553020..1553484 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" CDS 1553486..1554397 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" gene 1553486..1554397 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" promotor_-35 1554392..1554399 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1554414..1554433 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1554428 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" misc_RNA 1554437..1554553 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1554437..1554553 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" CDS 1554580..1555125 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" gene 1554580..1555125 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" downshifts complement(1554774) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" downshifts 1555116 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" misc_RNA 1555129..1555246 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1555129..1555246 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" CDS 1555299..1556606 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" gene 1555299..1556606 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" misc_RNA 1556607..1556721 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1556607..1556721 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" CDS 1556752..1557666 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" gene 1556752..1557666 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" CDS 1557650..1558936 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" gene 1557650..1558936 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" CDS 1558933..1560027 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" gene 1558933..1560027 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" CDS 1560012..1563227 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" gene 1560012..1563227 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" CDS 1563224..1563994 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" gene 1563224..1563994 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" CDS 1563994..1564929 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" gene 1563994..1564929 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" CDS 1564898..1565617 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" gene 1564898..1565617 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" CDS 1565596..1566246 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" gene 1565596..1566246 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" downshifts 1566248 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" S_feature 1566293..1566365 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1566345..1566352 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1566366..1566385 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1566367 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" misc_RNA 1566391..1566496 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" gene 1566391..1566496 /gene="mswE" /locus_tag="BSU_misc_RNA_29" S_feature 1566497..1566657 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1566658..1567359 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" gene 1566658..1567359 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" CDS 1567371..1568435 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" gene 1567371..1568435 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" CDS 1568484..1569632 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" gene 1568484..1569632 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" upshifts complement(1568573) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1568585..1568589) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1568607..1568608) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1569645..1570238 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" gene 1569645..1570238 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" S_feature 1570239..1570336 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1570337..1571110 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" gene 1570337..1571110 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" promotor_-35 1571015..1571022 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1571037..1571056 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1571038 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" CDS 1571113..1571898 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" gene 1571113..1571898 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" CDS 1571879..1572367 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" gene 1571879..1572367 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" downshifts 1572347 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" downshifts complement(1572394) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" CDS complement(1572407..1574125) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" gene complement(1572407..1574125) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" promotor_-10 complement(1574147..1574166) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1574161..1574166 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1574161) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" promotor_-35 complement(1574179..1574184) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1574182..1574200 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1574186 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" CDS 1574241..1576913 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" gene 1574241..1576913 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" promotor_-10 complement(1575646..1575665) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1575657) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1575680..1575687) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1576919..1576938 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1576922..1576995 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1576922 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1576996..1577871 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" gene 1576996..1577871 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" CDS 1577948..1578217 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" gene 1577948..1578217 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" misc_feature complement(1578028..1578032) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1578033) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1578225..1578839 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" gene 1578225..1578839 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" CDS 1578843..1579046 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" gene 1578843..1579046 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" downshifts 1579035 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" CDS 1579127..1580347 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" gene 1579127..1580347 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" S_feature complement(1580186..1580761) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1580344..1582761 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" gene 1580344..1582761 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" promotor_-10 complement(1580757..1580775) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1580761) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" promotor_-35 complement(1580789..1580795) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1582612..1582616 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1582632..1582651 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1582643 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1582788..1583270 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" gene 1582788..1583270 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" CDS 1583275..1584228 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" gene 1583275..1584228 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" CDS 1584215..1585558 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" gene 1584215..1585558 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" CDS 1585562..1586653 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" gene 1585562..1586653 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" CDS 1586660..1587424 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" gene 1586660..1587424 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" downshifts 1586713 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" CDS 1587418..1589364 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" gene 1587418..1589364 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" promotor_-35 1589273..1589279 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1589293..1589311 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1589309 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1589379..1590275 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" gene 1589379..1590275 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" CDS 1590280..1590933 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " gene 1590280..1590933 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" promotor_-35 1590931..1590940 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1590954..1590973 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1590959 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" CDS 1591006..1591650 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" gene 1591006..1591650 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" promotor_-35 1591411..1591417 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1591428 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" promotor_-10 1591432..1591450 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1591541..1591546 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1591562..1591580 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1591575 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" S_feature 1591651..1591721 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1591722..1591802 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" gene 1591722..1591802 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" downshifts 1591817 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" S_feature 1591862..1592234 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1591875..1592063) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" gene complement(1591875..1592063) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" downshifts complement(1591891) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" downshifts complement(1591937) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" S_feature complement(1592064..1592156) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1592138..1592157) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1592156) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" promotor_-35 complement(1592173..1592176) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1592207..1592214 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1592229..1592247 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1592236 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" promotor_-35 1592275..1592278 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1592293..1592312 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1592301 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" CDS 1592340..1592702 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" gene 1592340..1592702 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" downshifts complement(1592553) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" CDS 1592718..1594379 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" gene 1592718..1594379 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" S_feature 1594380..1594469 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1594442..1594449 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1594463..1594482 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1594471 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" CDS 1594518..1595180 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" gene 1594518..1595180 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" CDS 1595206..1596108 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" gene 1595206..1596108 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" CDS 1596086..1598134 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" gene 1596086..1598134 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" promotor_-35 1598170..1598177 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1598192..1598211 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1598198 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1598243..1598809 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" gene 1598243..1598809 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" CDS 1598823..1599824 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " gene 1598823..1599824 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" CDS 1599843..1600796 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" gene 1599843..1600796 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" CDS 1600789..1601529 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" gene 1600789..1601529 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" promotor_-35 1601560..1601564 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1601580..1601599 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1601585 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1601613..1601846 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" gene 1601613..1601846 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" downshifts 1601827 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" promotor_no_box 1601855..1601955 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1601915..1601985 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1601915 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1601986..1602735 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" gene 1601986..1602735 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" downshifts 1602707 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" promotor_-35 1602777..1602783 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1602795..1602814 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1602817 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" CDS 1602836..1606396 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" gene 1602836..1606396 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" S_feature complement(1606330..1607400) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1606416..1607405 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" gene 1606416..1607405 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" downshifts 1607392 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" CDS complement(1607442..1607927) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" gene complement(1607442..1607927) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" downshifts complement(1607445) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" promotor_-10 complement(1607949..1607967) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1607965) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" promotor_-35 complement(1607981..1607988) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1608030..1608036 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1608051..1608070 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1608053 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1608104..1608436 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" gene 1608104..1608436 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" downshifts complement(1608107) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" CDS 1608450..1609790 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" gene 1608450..1609790 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" S_feature 1609791..1609895 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1609896..1610168 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" gene 1609896..1610168 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" CDS 1610168..1610413 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" gene 1610168..1610413 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" downshifts 1610385 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" S_feature 1610430..1610534 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1610535..1610921 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" gene 1610535..1610921 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" CDS 1610926..1611450 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" gene 1610926..1611450 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" CDS 1611447..1612178 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" gene 1611447..1612178 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" promotor_-35 1612184..1612191 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1612205..1612224 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1612209 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" misc_RNA 1612257..1612298 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" gene 1612257..1612298 /locus_tag="BSU_misc_RNA_30" CDS 1612318..1612665 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" gene 1612318..1612665 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" downshifts 1612667 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" promotor_-35 1612720..1612726 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1612739..1612807 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1612739 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" promotor_-10 1612740..1612759 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1612808..1613656 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" gene 1612808..1613656 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" promotor_-35 1613677..1613684 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1613697..1613715 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1613707 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1613727..1614494 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" gene 1613727..1614494 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" CDS 1614526..1616256 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" gene 1614526..1616256 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" upshifts complement(1615763) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1615764..1615783) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1615798..1615805) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1616253..1616534 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" gene 1616253..1616534 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" downshifts 1616366 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" S_feature 1616535..1616654 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1616626..1616633 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1616647..1616666 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1616656 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1616707..1617864 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" gene 1616707..1617864 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" promotor_no_box complement(1616779..1616879) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1616819) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1617893..1618795 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" gene 1617893..1618795 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" downshifts 1618785 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" CDS 1618856..1619749 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" gene 1618856..1619749 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" promotor_-35 1619755..1619762 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1619777..1619796 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1619784..1619936 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1619784 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1619937..1622012 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" gene 1619937..1622012 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" downshifts 1621982 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" promotor_-35 1622044..1622049 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1622056 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" promotor_-10 1622065..1622083 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1622088..1623395 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" gene 1622088..1623395 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" promotor_-35 1623401..1623405 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1623422..1623441 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1623432 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1623463..1624377 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" gene 1623463..1624377 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" promotor_-35 1623502..1623506 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1623519 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" promotor_-10 1623522..1623541 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1624390..1624935 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" gene 1624390..1624935 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" CDS 1624952..1626355 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" gene 1624952..1626355 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" CDS 1626395..1627174 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" gene 1626395..1627174 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" downshifts 1627149 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" downshifts 1627193 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" promotor_-35 1627294..1627301 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1627314..1627332 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1627325..1627478 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1627325 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" promotor_-35 1627453..1627460 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1627475..1627494 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1627480 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1627554..1627943 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" gene 1627554..1627943 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" CDS 1627943..1628395 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" gene 1627943..1628395 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" CDS 1628406..1628726 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" gene 1628406..1628726 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" downshifts complement(1628721) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" CDS 1628772..1630382 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" gene 1628772..1630382 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" CDS 1630395..1631411 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" gene 1630395..1631411 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" S_feature 1631412..1631529 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1631475..1631575) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1631515) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1631530..1632156 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" gene 1631530..1632156 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" CDS 1632153..1633469 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" gene 1632153..1633469 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" CDS 1633472..1633915 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" gene 1633472..1633915 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" CDS 1633927..1634541 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" gene 1633927..1634541 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" CDS 1634554..1636017 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" gene 1634554..1636017 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" CDS 1636014..1636436 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" gene 1636014..1636436 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" CDS 1636458..1637252 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" gene 1636458..1637252 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" CDS 1637292..1637507 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" gene 1637292..1637507 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" CDS 1637504..1637926 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" gene 1637504..1637926 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" CDS 1637960..1638958 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" gene 1637960..1638958 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" CDS 1638948..1640084 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" gene 1638948..1640084 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" CDS 1640110..1640472 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" gene 1640110..1640472 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" CDS 1640487..1641146 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" gene 1640487..1641146 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" CDS 1641139..1641804 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" gene 1641139..1641804 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" CDS 1641819..1642088 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" gene 1641819..1642088 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" CDS 1642096..1642875 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" gene 1642096..1642875 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" CDS 1642875..1643957 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" gene 1642875..1643957 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" CDS 1643990..1646023 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" gene 1643990..1646023 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" CDS 1646023..1647123 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" gene 1646023..1647123 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" promotor_-10 complement(1647000..1647019) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1647007) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1647033..1647042) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1647114..1648010 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" gene 1647114..1648010 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" CDS 1648012..1649085 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" gene 1648012..1649085 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" CDS 1649091..1651109 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" gene 1649091..1651109 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" CDS 1651131..1651601 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" gene 1651131..1651601 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" CDS 1651620..1652249 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" gene 1651620..1652249 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" CDS 1652246..1652746 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" gene 1652246..1652746 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" CDS 1652769..1653533 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" gene 1652769..1653533 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" promotor_-35 1653543..1653549 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1653562..1654065 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" gene 1653562..1654065 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" promotor_-10 1653564..1653575 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1653578 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" promotor_-35 1654061..1654067 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1654082..1654101 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1654084..1654208 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1654084 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1654209..1654949 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" gene 1654209..1654949 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" downshifts 1654931 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" S_feature 1654976..1655050 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1655051..1655932 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" gene 1655051..1655932 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" S_feature 1655933..1656077 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1656078..1656800 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" gene 1656078..1656800 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" CDS 1656802..1657359 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" gene 1656802..1657359 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" downshifts complement(1657306) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" promotor_-35 1657348..1657351 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1657366..1657385 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1657384..1657489 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1657384 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1657490..1658272 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" gene 1657490..1658272 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" CDS 1658276..1659085 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" gene 1658276..1659085 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" promotor_-35 1659066..1659073 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1659088..1659107 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1659089 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1659147..1660298 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" gene 1659147..1660298 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" CDS 1660305..1661573 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" gene 1660305..1661573 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" CDS 1661606..1663300 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" gene 1661606..1663300 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" S_feature 1663301..1663408 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1663409..1667722 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" gene 1663409..1667722 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" S_feature 1667723..1667787 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1667733..1667950 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene 1667733..1667950 /gene="surG" /locus_tag="BSU_misc_RNA_71" promotor_-35 1667759..1667765 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1667780..1667791 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1667789..1667856 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1667789 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" promotor_-35 1667839..1667845 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1667858..1668051 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1667858 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" promotor_-10 1667859..1667878 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1668052..1668522 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" gene 1668052..1668522 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" downshifts complement(1668373) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" CDS 1668557..1669672 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" gene 1668557..1669672 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" promotor_no_box complement(1668619..1668719) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1668659) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1669686..1669961 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" gene 1669686..1669961 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" CDS 1669963..1670265 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" gene 1669963..1670265 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" CDS 1670285..1672435 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" gene 1670285..1672435 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" promotor_-35 1672330..1672336 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1672345 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" promotor_-10 1672351..1672369 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1672432..1672710 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" gene 1672432..1672710 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo CDS 1672727..1673080 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" gene 1672727..1673080 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" downshifts 1673071 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" CDS 1673162..1674091 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" gene 1673162..1674091 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" promotor_-35 1673876..1673883 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1673897..1673916 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1673906 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" CDS 1674110..1675060 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" gene 1674110..1675060 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" promotor_-35 1675093..1675099 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1675100..1675216 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1675100 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" promotor_-10 1675114..1675133 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1675217..1675486 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" gene 1675217..1675486 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" downshifts 1675469 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" S_feature 1675514..1675599 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1675580..1675583 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1675599..1675618 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1675601 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" CDS 1675659..1677776 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" gene 1675659..1677776 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" downshifts 1677559 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" downshifts 1677760 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" S_feature 1677805..1677893 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1677894..1678853 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" gene 1677894..1678853 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" promotor_-10 complement(1677962..1677970) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1677965) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1677984..1677991) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1678457..1678462 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1678478..1678496 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1678483 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" CDS 1678893..1680122 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" gene 1678893..1680122 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" downshifts 1680111 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" promotor_-35 1680151..1680156 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1680166 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" promotor_-10 1680172..1680190 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1680200..1680457 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" gene 1680200..1680457 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" S_feature 1680458..1680512 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1680485 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" promotor_-35 1680554..1680563 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1680573..1680642 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1680573 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" promotor_-10 1680577..1680596 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1680643..1681536 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" gene 1680643..1681536 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" CDS 1681539..1682141 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" gene 1681539..1682141 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" misc_feature 1682195..1682214 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1682195..1682266 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1682195 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" CDS 1682267..1683307 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" gene 1682267..1683307 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" S_feature 1683308..1683398 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1683399..1684613 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" gene 1683399..1684613 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" CDS 1684644..1685516 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" gene 1684644..1685516 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" S_feature complement(1684987..1686171) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1685523 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" promotor_-35 1685616..1685619 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1685633 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" promotor_-10 1685635..1685654 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1685694..1687361 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" gene 1685694..1687361 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" promotor_-10 complement(1686158..1686176) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1686175) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" promotor_-35 complement(1686192..1686197) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1687349 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" promotor_-35 1687416..1687422 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1687436..1687447 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1687437 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" CDS 1687477..1688214 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" gene 1687477..1688214 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" CDS 1688211..1688423 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" gene 1688211..1688423 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" misc_feature 1688451..1688470 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1688465 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" CDS 1688554..1690917 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" gene 1688554..1690917 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" S_feature 1690918..1691018 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1690979..1690986 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1691001..1691020 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1691019 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" CDS 1691061..1691786 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" gene 1691061..1691786 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" downshifts 1691773 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" promotor_-35 1691842..1691848 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1691861 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" promotor_-10 1691863..1691874 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1691925..1693133 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" gene 1691925..1693133 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" downshifts 1693091 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" promotor_-35 1693202..1693209 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1693222..1693241 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1693244 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" promotor_-35 1693256..1693259 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1693275..1693287 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1693289 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" CDS 1693313..1694593 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" gene 1693313..1694593 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" CDS 1694590..1695876 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" gene 1694590..1695876 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" downshifts 1695726 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" S_feature 1695877..1695930 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1695931..1696659 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" gene 1695931..1696659 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" promotor_-35 1696675..1696681 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1696693 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" promotor_-10 1696695..1696706 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1696706) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1696717..1696731) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1696740..1696744) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1696740..1696997 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" gene 1696740..1696997 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" downshifts 1696982 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" downshifts complement(1697014) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" promotor_-35 1697055..1697058 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1697073..1697092 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1697073 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" CDS 1697127..1697642 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" gene 1697127..1697642 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo CDS 1697578..1697916 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" gene 1697578..1697916 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo CDS 1697983..1698849 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" gene 1697983..1698849 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" promotor_no_box 1698046..1698146 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1698106 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" downshifts 1698809 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" CDS 1698899..1699480 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" gene 1698899..1699480 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" CDS 1699498..1700748 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" gene 1699498..1700748 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" S_feature 1700749..1700875 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1700855..1700862 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1700877..1700896 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1700877 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" CDS 1700921..1701967 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" gene 1700921..1701967 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" downshifts 1701979 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" S_feature 1702024..1702089 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1702061..1702070 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1702083..1702098 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1702091 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" CDS 1702135..1703310 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " gene 1702135..1703310 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" S_feature 1703311..1703410 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1703384..1703391 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1703405..1703424 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1703412..1703585 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1703412 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" CDS 1703586..1705148 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" gene 1703586..1705148 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" downshifts 1705125 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" CDS 1705217..1706011 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" gene 1705217..1706011 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" promotor_-35 1705766..1705771 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1705787..1705805 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1705807 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" promotor_-35 1706055..1706060 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1706071..1706210 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1706071 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" promotor_-10 1706076..1706094 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1706103) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1706114..1706127) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1706136..1706140) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1706147) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" CDS 1706211..1706471 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" gene 1706211..1706471 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" downshifts 1706423 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" downshifts complement(1706455) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" downshifts 1706467 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" S_feature 1706512..1706686 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1706670..1706677 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1706688 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" promotor_-10 1706692..1706711 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1706737..1707780 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" gene 1706737..1707780 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" CDS 1707793..1708971 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" gene 1707793..1708971 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" downshifts 1708953 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" promotor_-35 1709051..1709054 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1709063 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" promotor_-10 1709069..1709088 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1709119..1710648 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" gene 1709119..1710648 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" CDS 1710650..1711081 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" gene 1710650..1711081 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" downshifts 1711064 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1711212..1711217 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1711233..1711251 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1711241..1711342 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1711241 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" CDS 1711343..1711888 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" gene 1711343..1711888 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" downshifts 1711882 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" downshifts complement(1711889) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" promotor_-35 1711946..1711949 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1711964..1711983 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1711968 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" CDS 1712021..1714597 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" gene 1712021..1714597 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" CDS 1714613..1716496 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" gene 1714613..1716496 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" S_feature complement(1716399..1716893) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1716411 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" downshifts complement(1716421) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" promotor_-35 1716643..1716650 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1716665..1716684 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1716675..1716808 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1716675 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" misc_RNA complement(1716680..1716830) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" gene complement(1716680..1716830) /gene="surX" /locus_tag="BSU_misc_RNA_89" downshifts 1716765 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" CDS complement(1716894..1717349) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" gene complement(1716894..1717349) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" S_feature complement(1717350..1717441) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1717429..1717448) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717441) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" promotor_-35 complement(1717465..1717468) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1717504..1718061) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" gene complement(1717504..1718061) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" promotor_-35 1718145..1718152 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1718165..1718184 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1718167..1718185) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1718170 /Source="Nicolas_upshifts" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" upshifts complement(1718181) /Source="Nicolas_upshifts" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1718182..1718319 /created_by="AR/SM" /note="N-terminus of previously known orfA is fused to a chromosomal 3`sequence resulting in an artificial C-terminal extension of the truncated protein A, transcription and translation is driven from known promoters and SD of orfA " /NCBI_locus_tag="A8O17_RS20435" /locus_tag="Delta6_BSU_17080-art" /modified_by="User" /transl_table=11 /pseudo /translation="MPKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLE A*" /label="Delta6_BSU_17080-art" gene 1718182..1718319 /created_by="AR/SM" /note="N-terminus of previously known orfA is fused to a chromosomal 3`sequence resulting in an artificial C-terminal extension of the truncated protein A, transcription and translation is driven from known promoters and SD of orfA " /NCBI_locus_tag="A8O17_RS20435" /locus_tag="Delta6_BSU_17080-art" /modified_by="User" /label="Delta6_BSU_17080-art" promotor_-35 complement(1718200..1718205) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1718297,1719360) /created_by="User" /modified_by="User" /label="Delta5" N_region 1718298..1719359 /note="insertion of sequence with unknown origin - insert contains an independent promoter SD and chloramphenicol resistance gene" /created_by="User" /label="Delta5" promotor_-35 1718516..1718521 /created_by="User" /label="Delta5_SigA_-35" promotor_-10 1718539..1718544 /created_by="User" /label="Delta5_SigA_-10" upshifts complement(1718578) /Source="Nicolas_upshifts" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1718608..1719327 /gene="catA" /NCBI_locus_tag="A8O17_RS08865" /old_locus_tag="A8O17_08865" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_032488880.1" /note="frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="type A chloramphenicol O-acetyltransferase" /locus_tag="Delta6_NEW_001" /modified_by="User" /translation="MNFNKIDLDNWKRKEIFNHYLNQQTTFSITTEIDISVLYRNIKQ EGYKFYPAFIFLVTRVINSNTAFRTGYNSDGELGYWDKLEPLYTIFDGVSKTFSGIWT PVKNDFKEFYDLYLSDVEKYNGSGKLFPKTPIPENAFSLSIIPWTSFTGFNLNINNNS NYLLPIITAGKFINKGNSIYLPLSLQVHHSVCDGYHAGLFMNSIQELSDRPNDWLL*Y EIMPTVLFTVGFLMSLTCPVS*" /label="Delta6_NEW_001" gene 1718608..1719327 /gene="catA" /locus_tag="Delta6_NEW_001" /old_locus_tag="A8O17_08865" /pseudo /NCBI_locus_tag="A8O17_RS08865" /modified_by="User" /label="Delta6_NEW_001" CDS 1719360..1719842 /note="pseudogene - residual C-terminal sequence due to internal deletion scar" /created_by="AR/SM" /NCBI_locus_tag="A8O17_08870" /locus_tag="Delta6_pseudo_BSU_17220" /modified_by="User" /transl_table=11 /pseudo /translation="EFLSELIDLAKERGLNKPDKQIRAQAQQMMKTQRAYDLESYTVK PLPDPETVKCYYFRNKSRSFFGDLDTYFTLSNEKEPFDQAAYWEEWERQIPHFHLVDV DSSNHFMILTEPKASTALLEFCEKLYSNRGVVNANFLKAFRKKHEAREEKETDELVKR *" /label="Delta6_pseudo_BSU_17220" gene 1719360..1719842 /note="pseudogene - residual C-terminal sequence due to internal deletion scar " /created_by="AR/SM" /NCBI_locus_tag="A8O17_08870" /locus_tag="Delta6_pseudo_BSU_17220" /modified_by="User" /label="Delta6_pseudo_BSU_17220" downshifts 1719831 /Source="Nicolas_upshifts" /id="D927" /incds=0 /nref=65 /ntot=216 /MaxReadThrough="0.92789" /MaxDrop="5.77685" /score="4.87908333" /energy="-14.6" /TU="NA" /idTUdmin="U1370" /TUdmin=1 /isTUend="TRUE" CDS complement(1719887..1721104) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 17482575, 16707694, 17234808, 17886826, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 of bacillaene metabolism" /protein_id="NP_389605.2" /db_xref="EnsemblGenomes-Gn:BSU17230" /db_xref="EnsemblGenomes-Tr:CAB13607" /db_xref="GOA:O31785" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4YZR" /db_xref="SubtiList:BG12655" /db_xref="UniProtKB/Swiss-Prot:O31785" /translation="MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPA WLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRL RSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVH AEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIAT AVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILN INRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVF LRGLESLPVSLSK*" gene complement(1719887..1721104) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" downshifts complement(1719906) /Source="Nicolas_upshifts" /id="D928" /incds=0 /nref=123 /ntot=225 /MaxReadThrough="0.911470000000001" /MaxDrop="4.23567" /score="16.9796453" /energy="-16.8" /TU="NA" /idTUdmin="U1373" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(1721119..1721219) /Source="Nicolas_upshift_promotors" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1721159) /Source="Nicolas_upshifts" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" promotor_-10 complement(1721191..1721210) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1721203) /Source="Nicolas_upshifts" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" S_feature complement(1721205..1721285) /Source="Nicolas_S_feature" /locus_tag="new_1859884_1859964_c" /HighExp="Salt, Etha, T-3.40H, T-0.40H, T-1.40H, LoTm, T-2.40H, S1, SMM, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.122" /TUlongSig="NA" /TUlongPSig="NA" /label="S618" promotor_-35 complement(1721225..1721232) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1721329) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" CDS complement(1721335..1721691) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" gene complement(1721335..1721691) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" misc_feature complement(1721751..1721764) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1721756) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" CDS complement(1721770..1722594) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" gene complement(1721770..1722594) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" promotor_-10 complement(1722616..1722635) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1722632) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" promotor_-35 complement(1722647..1722653) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1722705..1724033) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" gene complement(1722705..1724033) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" downshifts complement(1722712) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" promotor_-10 complement(1724056..1724075) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1724075) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" promotor_-35 complement(1724089..1724097) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1724190..1724197 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1724205..1724224) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1724213..1724232 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1724216) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" upshifts 1724219 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" promotor_-35 complement(1724237..1724244) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1724258..1724335 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" gene 1724258..1724335 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo downshifts complement(1724260) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" CDS 1724313..1724489 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" gene 1724313..1724489 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo downshifts 1724470 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" S_feature 1724515..1724703 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1724698..1724717 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1724705 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" CDS 1724769..1725476 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" gene 1724769..1725476 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" promotor_-35 1725487..1725493 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1725507..1725526 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1725511 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" CDS 1725546..1725998 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" gene 1725546..1725998 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" downshifts 1725986 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" CDS complement(1726012..1726365) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" gene complement(1726012..1726365) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" downshifts complement(1726053) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" CDS complement(1726379..1726696) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" gene complement(1726379..1726696) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" promotor_-10 complement(1726740..1726759) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1726748) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" promotor_-35 complement(1726774..1726781) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1726833..1727108) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" gene complement(1726833..1727108) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" downshifts complement(1726834) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" promotor_-35 1727104..1727109 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1727125..1727143 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1727135..1727154) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1727145 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" upshifts complement(1727148) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" promotor_-35 complement(1727167..1727176) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1727197..1727610 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" gene 1727197..1727610 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" upshifts 1727661 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" misc_feature 1727667..1727686 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1727710..1728654 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" gene 1727710..1728654 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" promotor_-35 1728634..1728642 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1728653..1728671 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1728655 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" CDS 1728694..1728915 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" gene 1728694..1728915 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" downshifts complement(1728705) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" promotor_-10 complement(1728767..1728771) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728771) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1728786..1728791) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1728915 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" CDS 1729111..1729383 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" gene 1729111..1729383 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" promotor_-35 1729399..1729406 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1729420..1729439 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1729422 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" CDS 1729465..1729695 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" gene 1729465..1729695 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" S_feature 1729696..1729772 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1729729 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" S_feature 1729774..1729881 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1729854..1729861 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1729875..1729894 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1729883 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" CDS 1729938..1730330 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" gene 1729938..1730330 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" CDS 1730290..1732392 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" gene 1730290..1732392 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" CDS 1732410..1733399 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" gene 1732410..1733399 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" downshifts 1733359 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" S_feature complement(1733413..1734072) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1733428) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" CDS 1733449..1734069 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" gene 1733449..1734069 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" downshifts 1734050 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" promotor_-35 1734085..1734089 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1734107..1734474 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1734107 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" promotor_-10 1734111..1734128 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1734117) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" CDS complement(1734133..1734900) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" gene complement(1734133..1734900) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" promotor_-10 complement(1734909..1734928) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734932) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" promotor_-35 complement(1734941..1734950) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1735054..1735059 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1735075..1735093 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1735075 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1735357..1735362 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1735379..1735397 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1735383..1735523 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1735383 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" CDS 1735524..1736492 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" gene 1735524..1736492 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" downshifts 1736461 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" promotor_-35 1736556..1736564 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1736571 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" promotor_-10 1736575..1736594 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1736625..1737887 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" gene 1736625..1737887 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" CDS 1737905..1739170 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" gene 1737905..1739170 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" promotor_-35 1739218..1739225 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1739240..1739259 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1739252 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" CDS 1739280..1739687 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" gene 1739280..1739687 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" downshifts complement(1739286) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" misc_feature 1739668..1739686 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1739693 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" downshifts complement(1739746) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" CDS 1739746..1741080 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" gene 1739746..1741080 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" downshifts 1741057 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" S_feature 1741102..1741362 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" promotor_-35 1741337..1741344 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1741359..1741378 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1741364 /Source="Nicolas_upshifts" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" CDS 1741408..1741698 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective, phage region" /protein_id="NP_389629.1" /db_xref="EnsemblGenomes-Gn:BSU17470" /db_xref="EnsemblGenomes-Tr:CAB13631" /db_xref="GOA:P31844" /db_xref="SubtiList:BG11074" /db_xref="UniProtKB/Swiss-Prot:P31844" /translation="MKKLTIFSGGLGAVFSVLAQLFAVIDDSYTLGNLWFLGALAGII TMLASIQTNNKPVFSILLIASSVIGLLGTGLVYIIPTLFNIIIIYKFSKVSQ*" gene 1741408..1741698 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" S_feature 1741699..1741943 /Source="Nicolas_S_feature" /locus_tag="new_1880378_1880622" /HighExp="Cold, M9-stat, BC, B60, LPhT, T0.30H, LBGstat, LoTm, S4, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49198399999999998" /TUshortSig="SigA, SigL, SigA" /TUshortPSig="0.997, 0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S626" CDS 1741944..1742288 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389630.1" /db_xref="EnsemblGenomes-Gn:BSU17480" /db_xref="EnsemblGenomes-Tr:CAB13632" /db_xref="SubtiList:BG13469" /db_xref="UniProtKB/Swiss-Prot:O31799" /translation="MWKALSQLLKKQKNQSPSDEDYIQIPELEVKVLGMLHSINIDLV NVIAQAEKSKEFIGQIEGIWHSIANQFYSLAQGFENEDINKLSADLDHAAATWEAVAN KAKEFVTNSYQG*" gene 1741944..1742288 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" downshifts 1742266 /Source="Nicolas_upshifts" /id="D947" /incds=0 /nref=31 /ntot=125 /MaxReadThrough="3.06401" /MaxDrop="4.27622" /score="-0.54122646" /energy="-8.3" /TU="U1394,U1396" /idTUdmin="U1394" /TUdmin="-440" /isTUend="FALSE" CDS 1742419..1742670 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389631.1" /db_xref="EnsemblGenomes-Gn:BSU17490" /db_xref="EnsemblGenomes-Tr:CAB13633" /db_xref="SubtiList:BG13470" /db_xref="UniProtKB/Swiss-Prot:O31800" /translation="MLGINVEKSNENLIINWQLSKIEIPIKEINDVFLDPNYGGEEKS AVRIGFPYGSTDRVVIKTARNTYILFTTNPALIMSKIVS*" gene 1742419..1742670 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" promotor_-35 1742696..1742703 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1742714..1742733 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1742727..1742856 /Source="Nicolas_S_feature" /locus_tag="new_1881406_1881535" /HighExp="LoTm, Etha, LPhT, B60, M9-stat, T3.0H, T3.30H, Salt, T4.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.968584" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.997, 1, 1" /label="S627" upshifts 1742727 /Source="Nicolas_upshifts" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" CDS 1742857..1743291 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" /function="17.2: Prophage functions" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389632.2" /db_xref="EnsemblGenomes-Gn:BSU17500" /db_xref="EnsemblGenomes-Tr:CAB13634" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG12254" /db_xref="UniProtKB/Swiss-Prot:P94480" /translation="MEDATFHFKDPASPQEISDIEQKLGVTFPNDYKEFLLQHNGMEM FDGIEILSLEGIIEYNEVQDFPEGYVLIGYHFDGRYVIDTNKSKNGLGYMLYLDSIDD IEDAINLDSNFEIWFDMLVSLNGTKYWEVNPNLQEYYKLVSE*" gene 1742857..1743291 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" CDS 1743361..1744152 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389633.1" /db_xref="EnsemblGenomes-Gn:BSU17510" /db_xref="EnsemblGenomes-Tr:CAB13635" /db_xref="SubtiList:BG12255" /db_xref="UniProtKB/Swiss-Prot:P94481" /translation="MTIYEQIKDALKNKINELVSPQEVKKTLQEKYGTNPDSIILSDY CYNRYNKGISFNKHLFEYMNRSSYKYLGENSLYTGLIFRKSKGEDKEVIVGEWVNGVK SLREASVTNNQINDQAEIISKEQLVNLYNEYNQILRYEMNVLNCKPTELRHLIGRIGE FICAIQTNGTLARQTNQHGFDVVSDGRRISVKTTAQSSGFISINKNTFYDFDDFFVVQ YVNDDFKVIFFGSKEEVQKISRIYGSQYEVEISLLKKLNKEYQLN*" gene 1743361..1744152 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" promotor_-10 complement(1743469..1743488) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1743477) /Source="Nicolas_upshifts" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1743504..1743506) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1744148 /Source="Nicolas_upshifts" /id="D948" /incds=0 /nref=10 /ntot=182 /MaxReadThrough="4.47202" /MaxDrop="6.29359" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-836" /isTUend="FALSE" downshifts 1744214 /Source="Nicolas_upshifts" /id="D949" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="3.36892" /MaxDrop="4.40772" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-770" /isTUend="FALSE" promotor_-35 1744425..1744433 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1744445..1744463 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1744456 /Source="Nicolas_upshifts" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" CDS 1744487..1744999 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase; putative phage region" /protein_id="NP_389634.1" /db_xref="EnsemblGenomes-Gn:BSU17520" /db_xref="EnsemblGenomes-Tr:CAB13636" /db_xref="GOA:P94482" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12256" /db_xref="UniProtKB/Swiss-Prot:P94482" /translation="MHITTKRLLIREFEFKDWQAVYEYTSDSNVMKYIPEGVFTEEDA KAFVNKNKGDNAEKFPVILRDEDCLIGHIVFYKYFGEHTYEIGWVFNPNYQNKGYASE AAQAILEYGFKEMNLHRIIATCQPENIPSYRVMKKIGMRREGFFKKCIPKGNEWWDEY YYAILEEEWN*" gene 1744487..1744999 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" promotor_-35 1745446..1745452 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1745446 /Source="Nicolas_upshifts" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" promotor_-35 1745448..1745452 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1745466..1745485 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1745466..1745485 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1745490..1745558 /Source="Nicolas_S_feature" /locus_tag="new_1884169_1884237" /HighExp="T1.30H, M9-stat, Lbtran, M0t90, T0.30H, T1.0H, T2.30H, Lbstat, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S628" upshifts 1745490 /Source="Nicolas_upshifts" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" CDS 1745559..1746200 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389635.1" /db_xref="EnsemblGenomes-Gn:BSU17530" /db_xref="EnsemblGenomes-Tr:CAB13637" /db_xref="InterPro:IPR024976" /db_xref="SubtiList:BG12257" /db_xref="UniProtKB/Swiss-Prot:P94483" /translation="MNLIGYIEERFQNLELIPSIYNQWGTGIHFCLGENIYQLKANEE LNLKMFRIVYEQTSIIFNELFEQNDDIFLVTNMYKHKKKEKCIRKLKVYQPFLKCKNH LNQIMVKTYPYPFEINKAEEYEMQQFSLLCKPRDLRVTELLKAASNEDFPQKPKFGGY SIDYPDVFFVNITKDIIFFIYDDRGCEVIAHDFKRIRPLYEKYHDWVEEYKCM*" gene 1745559..1746200 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" S_feature 1746201..1746288 /Source="Nicolas_S_feature" /locus_tag="new_1884880_1884967" /HighExp="M0t90, Lbtran, Lbstat, T1.30H, S2, T1.0H, T0.30H, MG 150, M9-stat, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S629" CDS 1746289..1746642 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389636.1" /db_xref="EnsemblGenomes-Gn:BSU17540" /db_xref="EnsemblGenomes-Tr:CAB13638" /db_xref="SubtiList:BG12258" /db_xref="UniProtKB/Swiss-Prot:P94484" /translation="MVLCDDERSAFLLVLDERLVDFDSQGGNHISVYLVTHFELSDQS YKDVLSFNDDLLGMEHNCSYAMDILSVKEELDFDFPFNMLAIKSYVQELIKMLGIDIT LPEMKERDFDKLSQN*" gene 1746289..1746642 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" CDS 1746686..1746961 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389637.1" /db_xref="EnsemblGenomes-Gn:BSU17550" /db_xref="EnsemblGenomes-Tr:CAB13639" /db_xref="GOA:P94485" /db_xref="SubtiList:BG12259" /db_xref="UniProtKB/Swiss-Prot:P94485" /translation="MNVKKAAAVFSITIPIISAILIINFFTGFMSIPWQGMPVFFPLL LSPIGIILAFVSIKTNKRCAVYGIVLNAIMFPFPFFWFIGGALLFGV*" gene 1746686..1746961 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" downshifts complement(1747062) /Source="Nicolas_upshifts" /id="D950" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="1.74772" /MaxDrop="3.30031" /score="-7.48025946" /energy="-14.4" /TU="NA" /idTUdmin="U1402" /TUdmin=308 /isTUend="FALSE" CDS 1747074..1747238 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="YP_003097730.1" /db_xref="EnsemblGenomes-Gn:BSU17559" /db_xref="EnsemblGenomes-Tr:CAX52623" /db_xref="GOA:C0H415" /db_xref="UniProtKB/Swiss-Prot:C0H415" /translation="MDRKKDEIQRKYREQMREKKEREKEDGSSHTFEIVVVLAIIILM FFFNSVFKAF*" gene 1747074..1747238 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" S_feature 1747239..1747377 /Source="Nicolas_S_feature" /locus_tag="new_1885918_1886056" /HighExp="M0t90, Lbstat, S1, Lbtran, S2, M40t90, T1.30H, Glu, T1.0H, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S630" CDS 1747378..1747848 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389638.3" /db_xref="EnsemblGenomes-Gn:BSU17560" /db_xref="EnsemblGenomes-Tr:CAB13640" /db_xref="SubtiList:BG12261" /db_xref="UniProtKB/Swiss-Prot:P94487" /translation="MKLYNEFINIAKTFNKELDIIPLLYGSLGLEKVTGLDFSPEDID LLIPLIFLEEKWEKLKKVMELHGYKMVDLHEHEFKKTNTKIGISYIEDLKPFADVDYN NLEIFEDGGAKYHLLTIDDYLKIYKKSLLDGYRRRKKNHKDQSKINILNKLIRN*" gene 1747378..1747848 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" S_feature 1747849..1748672 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1748012..1748030) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1748030) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1748046..1748051) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1748673..1750064 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" gene 1748673..1750064 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" CDS 1750095..1751696 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" gene 1750095..1751696 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" S_feature complement(1750211..1750516) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1750511..1750530) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750516) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" promotor_-35 complement(1750544..1750552) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1751694 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" CDS complement(1751833..1752987) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" gene complement(1751833..1752987) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" downshifts complement(1751836) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" S_feature complement(1752886..1753064) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1753032..1753038 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1753047..1753066) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1753048..1753064 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1753058 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1753064) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" promotor_-35 complement(1753081..1753084) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1753091..1753098 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1753113..1753132 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1753124..1753228 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1753125 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" CDS 1753229..1754566 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" gene 1753229..1754566 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" S_feature 1754567..1754641 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1754598 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" CDS 1754717..1756216 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" gene 1754717..1756216 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" S_feature 1756217..1756532 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1756490 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" CDS complement(1756699..1757334) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" gene complement(1756699..1757334) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" promotor_-10 complement(1757371..1757390) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1757380) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" promotor_-35 complement(1757405..1757412) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1757522..1757529 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1757544..1757563 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1757546..1757744 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1757546 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" CDS 1757745..1759160 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" gene 1757745..1759160 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" downshifts 1759150 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" downshifts complement(1759253) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" CDS complement(1759262..1760446) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" gene complement(1759262..1760446) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" S_feature complement(1760447..1760526) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1760519..1760537) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1760530) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" promotor_-35 complement(1760553..1760558) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1760838..1760845 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1760860..1760879 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1760868 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" CDS 1760910..1761371 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" gene 1760910..1761371 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" CDS 1761401..1761835 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" gene 1761401..1761835 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" S_feature complement(1761584..1761889) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1761682 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" S_feature 1761836..1762932 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1761891..1762176) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1761934) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(1762171..1762190) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1762176) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" promotor_-35 complement(1762202..1762207) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1762438) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" CDS complement(1762438..1762698) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" gene complement(1762438..1762698) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" promotor_-10 complement(1762719..1762738) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1762729) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" promotor_-35 complement(1762751..1762760) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1762933..1763058 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" gene 1762933..1763058 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo S_feature 1763059..1763175 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1763102..1763266 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" gene 1763102..1763266 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" promotor_-35 1763150..1763159 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1763173..1763192 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1763177..1763487 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1763177 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" promotor_-35 1763468..1763475 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1763489..1763508 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1763489 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" CDS 1763540..1764379 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" gene 1763540..1764379 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" promotor_-10 complement(1763562..1763581) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1763583) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1763596..1763599) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1764339 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" downshifts complement(1764485) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" S_feature complement(1764486..1764792) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1764502..1764789) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" gene complement(1764502..1764789) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" downshifts complement(1764529) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" promotor_-35 1764616..1764624 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1764638..1764657 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1764640 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" S_feature 1764651..1764811 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1764783 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" CDS complement(1764832..1765554) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" gene complement(1764832..1765554) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" downshifts complement(1764837) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1765579..1765598) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1765587) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" S_feature complement(1765589..1765713) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1765714..1766070) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" gene complement(1765714..1766070) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" promotor_-10 complement(1766094..1766113) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1766111) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" promotor_-35 complement(1766129..1766133) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1766310) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" CDS complement(1766316..1766516) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" gene complement(1766316..1766516) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" downshifts 1766499 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" promotor_-10 complement(1766538..1766557) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1766550) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" promotor_-35 complement(1766570..1766579) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1766691..1766879) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" gene complement(1766691..1766879) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" downshifts complement(1766707) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" misc_feature complement(1766848..1766855) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1766861) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" promotor_-10 complement(1766908..1766927) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1766926) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" promotor_-35 complement(1766942..1766949) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1766958..1767095 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" gene 1766958..1767095 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" promotor_-35 1766989..1766994 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1767009..1767027 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1767027..1767129 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1767027 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" CDS 1767130..1767528 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" gene 1767130..1767528 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" S_feature 1767529..1768333 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1767593..1768027) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" gene complement(1767593..1768027) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" downshifts complement(1767609) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1768057..1768076) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1768073) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" promotor_-35 complement(1768090..1768097) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1768334..1768522 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" gene 1768334..1768522 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" S_feature 1768523..1768608 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1768567 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" promotor_-35 1768637..1768643 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1768655..1768814 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1768655 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" promotor_-10 1768657..1768668 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1768815..1770377 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" gene 1768815..1770377 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" promotor_-10 complement(1769118..1769137) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769127) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1769152..1769159) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1770407..1771498 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" gene 1770407..1771498 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" CDS 1771488..1772702 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" gene 1771488..1772702 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" promotor_-35 1772780..1772787 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1772802..1772821 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1772813 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" CDS 1772849..1773655 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" gene 1772849..1773655 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" S_feature complement(1773463..1774561) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1773660..1774277 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" gene 1773660..1774277 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" CDS 1774274..1775914 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" gene 1774274..1775914 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" promotor_-10 complement(1774548..1774567) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774561) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" promotor_-35 complement(1774581..1774589) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1775554..1776320) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1775951..1776316 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" gene 1775951..1776316 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" downshifts 1776293 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" misc_RNA complement(1776313..1776593) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene complement(1776313..1776593) /gene="surA" /locus_tag="BSU_misc_RNA_72" S_feature complement(1776322..1776453) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1776365) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" promotor_-35 1776413..1776422 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1776435..1776444) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1776436..1776455 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1776441 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" S_feature 1776443..1776541 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1776453) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" S_feature complement(1776455..1776585) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1776542..1777300 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" gene 1776542..1777300 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" promotor_-35 1776568 /Source="Nicolas_upshift_promotors" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1776570 /Source="Nicolas_upshift_promotors" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1776575 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" promotor_-10 complement(1776591..1776610) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1776592) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" promotor_-35 complement(1776625..1776632) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1777115..1777326) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1777279 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" S_feature 1777324..1777943 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1777327..1777866) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" gene complement(1777327..1777866) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" promotor_-10 complement(1777867..1777881) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1777873) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" promotor_-35 complement(1777895..1777901) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1777921..1777930 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1777943..1777958 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1777945 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" CDS 1777984..1778418 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" gene 1777984..1778418 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" CDS 1778276..1778623 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" gene 1778276..1778623 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" S_feature 1778419..1778751 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1778710..1778719 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1778731..1778746 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1778753..1778931 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1778753 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" misc_RNA 1778822..1778901 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene 1778822..1778901 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" downshifts 1778888 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" CDS complement(1778960..1779577) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" gene complement(1778960..1779577) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" downshifts complement(1778961) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(1779601..1779620) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1779622) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" promotor_-35 complement(1779634..1779641) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1779657..1779664 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1779676 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" promotor_-10 1779678..1779697 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1779727..1780044 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" gene 1779727..1780044 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" promotor_-10 complement(1779744..1779762) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1779747) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1779776..1779783) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1780063..1780716 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " gene 1780063..1780716 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" promotor_-35 1780719..1780726 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1780740..1780759 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1780753 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" CDS 1780780..1781013 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" gene 1780780..1781013 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" S_feature 1781014..1781149 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1781117..1781124 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1781138..1781157 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1781151 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" CDS 1781182..1783185 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" gene 1781182..1783185 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" misc_feature complement(1781386..1781405) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1781403) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1783175 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" S_feature complement(1783187..1783845) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1783285 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" misc_feature 1783286..1783305 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1783338..1783784 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" gene 1783338..1783784 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" misc_feature 1783808..1783827 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1783816 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" promotor_-10 complement(1783827..1783844) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1783845) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" promotor_-35 complement(1783863..1783867) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1783870..1784088 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" gene 1783870..1784088 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" downshifts 1784100 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" S_feature 1784145..1784444 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1784162..1784335) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" gene complement(1784162..1784335) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" downshifts complement(1784175) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1784373..1784392) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1784380) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" promotor_-35 complement(1784406..1784413) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1784415..1784423 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1784435..1784454) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1784435..1784453 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1784446..1784554 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1784446 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" upshifts complement(1784447) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" promotor_-35 complement(1784469..1784476) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1784555..1785262 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" gene 1784555..1785262 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" promotor_-35 1785282..1785289 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1785301..1785320 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1785309 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" CDS 1785351..1785713 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" gene 1785351..1785713 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" promotor_-35 1785731..1785734 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1785749..1785768 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1785760 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" CDS 1785792..1786283 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" gene 1785792..1786283 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" downshifts 1786279 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" CDS complement(1786314..1786742) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" gene complement(1786314..1786742) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" downshifts complement(1786331) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1786760..1786779) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1786772) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" S_feature complement(1786774..1786859) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1786793..1786800) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1786830..1786839 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1786849..1786958 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1786849 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" promotor_-10 1786852..1786871 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1786854..1786873) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1786859) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" S_feature complement(1786861..1786944) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1786888..1786891) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1786915 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" CDS complement(1786976..1787368) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" gene complement(1786976..1787368) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" downshifts complement(1786989) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" promotor_-35 1787211..1787216 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1787232..1787250 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1787236 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" promotor_-35 1787346..1787350 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1787360..1787374 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1787375..1787394) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1787377 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1787390) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" promotor_-35 complement(1787408..1787417) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1787449..1787595) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" gene complement(1787449..1787595) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" downshifts complement(1787470) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" CDS complement(1787627..1787773) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" gene complement(1787627..1787773) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" S_feature 1787773..1787906 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1787773 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 1787784..1787786 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1787789..1787800) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1787803) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" promotor_-35 complement(1787815..1787821) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1787896..1787903 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1787908..1788000 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1787908 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" promotor_-10 1787918..1787937 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1787959) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" CDS 1788001..1790730 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" gene 1788001..1790730 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" misc_feature complement(1788021..1788025) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1788025) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1790731..1790801 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1790802..1791314 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" gene 1790802..1791314 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" downshifts 1791271 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" promotor_-35 1791340..1791346 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1791359 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" promotor_-10 1791361..1791372 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1791395..1791520 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" gene 1791395..1791520 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" downshifts complement(1791413) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" promotor_-35 1791534..1791540 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1791555..1791566 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1791557 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" CDS 1791585..1791731 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" gene 1791585..1791731 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" CDS 1791768..1792019 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" gene 1791768..1792019 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" downshifts 1791997 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" promotor_-35 1792040..1792045 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1792059..1792078 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1792063..1792154 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1792063 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" CDS 1792155..1792520 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" gene 1792155..1792520 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" CDS 1792536..1792835 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" gene 1792536..1792835 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" downshifts 1792811 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" CDS complement(1792866..1793153) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" gene complement(1792866..1793153) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" downshifts complement(1792887) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" downshifts complement(1792953) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" promotor_-10 complement(1793183..1793202) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1793195) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" promotor_-35 complement(1793218..1793225) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1793241..1793822) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" gene complement(1793241..1793822) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" S_feature 1793823..1793953 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1793848..1793867) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1793865) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" promotor_-35 1793938..1793941 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1793955 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" promotor_-10 1793957..1793976 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1793992..1794399 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" gene 1793992..1794399 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" downshifts 1794395 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" promotor_-35 1794461..1794464 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1794479..1794498 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1794483..1794797 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1794483 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" CDS 1794798..1796765 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" gene 1794798..1796765 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" CDS 1796769..1799189 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" gene 1796769..1799189 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" downshifts 1799169 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" S_feature complement(1799197..1799386) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1799236..1799412) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" gene complement(1799236..1799412) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo downshifts complement(1799240) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" CDS complement(1799387..1799797) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" gene complement(1799387..1799797) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo promotor_-10 complement(1799770..1799789) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1799773) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1799804..1799811) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1799838..1799857) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1799839) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1799872..1799879) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1799886..1799905) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1799897) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1799919..1799928) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1800145..1800150 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1800163..1800182 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1800168 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" S_feature 1800181..1800245 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1800246..1801643 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" gene 1800246..1801643 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" downshifts 1801632 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" downshifts 1801677 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" S_feature complement(1801733..1802479) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1801856..1801863 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1801875 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" promotor_-10 1801876..1801895 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1801946..1803445 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" gene 1801946..1803445 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" promotor_-10 complement(1802478..1802497) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1802501) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" promotor_-35 complement(1802511..1802520) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1803393 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" CDS 1803513..1803776 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" gene 1803513..1803776 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" downshifts complement(1804035) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" CDS complement(1804035..1805303) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" gene complement(1804035..1805303) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" S_feature complement(1805304..1805433) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1805434..1806975) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" gene complement(1805434..1806975) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" S_feature complement(1806976..1807297) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1807287..1807306) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1807298) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" promotor_-35 complement(1807321..1807324) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1807524..1807531 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1807544..1807563 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1807551 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1807570..1808016 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" gene 1807570..1808016 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" CDS 1808023..1808916 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" gene 1808023..1808916 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" misc_feature 1808533..1808552 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1808541 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" CDS 1808989..1809585 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" gene 1808989..1809585 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" downshifts 1809575 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" CDS complement(1809634..1810833) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" gene complement(1809634..1810833) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" S_feature complement(1810834..1810905) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1810893..1810904) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1810905) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" promotor_-35 complement(1810919..1810925) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1811003..1812538) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" gene complement(1811003..1812538) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" downshifts complement(1811015) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" CDS complement(1812549..1813331) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" gene complement(1812549..1813331) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" CDS complement(1813352..1814251) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" gene complement(1813352..1814251) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" CDS complement(1814266..1814487) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" gene complement(1814266..1814487) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" CDS complement(1814502..1815836) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" gene complement(1814502..1815836) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" CDS complement(1815846..1817495) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" gene complement(1815846..1817495) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" promotor_no_box 1815895..1815995 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1815955 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1817539..1818681) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" gene complement(1817539..1818681) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" promotor_-10 complement(1818700..1818718) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1818717) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" promotor_-35 complement(1818734..1818739) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1818772..1819077) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " gene complement(1818772..1819077) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" CDS complement(1819067..1819240) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" gene complement(1819067..1819240) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" CDS complement(1819348..1820880) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" gene complement(1819348..1820880) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" downshifts complement(1819359) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(1820915..1820934) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820915) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" promotor_-35 complement(1820947..1820956) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1821016..1821408) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" gene complement(1821016..1821408) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" downshifts complement(1821047) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1821436..1821447) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1821443) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" promotor_-35 complement(1821461..1821467) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1821519..1825358) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /EC_number="2.3.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 12486459, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 12486459, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase E" /protein_id="NP_389712.1" /db_xref="EnsemblGenomes-Gn:BSU18300" /db_xref="EnsemblGenomes-Tr:CAB13713" /db_xref="GOA:O31827" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11962" /db_xref="UniProtKB/Swiss-Prot:O31827" /translation="MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQS LFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDI SHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSA PSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQ YNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEML EAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVS EQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADF SFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELD KRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVS FMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYT SGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGA SLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEA LSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYIL DTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWL PDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYV GDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQN IILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPI DFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLAL LLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERK GLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEG HIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADII LDILEKITSNQVILHKR*" gene complement(1821519..1825358) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" downshifts complement(1821531) /Source="Nicolas_upshifts" /id="D1001" /incds=0 /nref=51 /ntot=190 /MaxReadThrough="0.85603" /MaxDrop="4.50208" /score="20.3407616" /energy="-16.7" /TU="NA" /idTUdmin="U1479" /TUdmin="-484" /isTUend="FALSE" CDS complement(1825366..1836177) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase D involved in synthesis of plipastatin" /protein_id="NP_389713.2" /db_xref="EnsemblGenomes-Gn:BSU18310" /db_xref="EnsemblGenomes-Tr:CAB13714" /db_xref="GOA:P94459" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11961" /db_xref="UniProtKB/Swiss-Prot:P94459" /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGK VNPQFFQNSINALVERHDIFRTIFISQNVSSPQQVVLRERNVIVLEEDITHLNEAEQS QFIEQWKEKDRDRGFHLQKDVLMRIALIQTGESQYSCIWTFHHIMMDGWCLSIVLKEF LHIYASYVNASPITLEPVQPYGKYIKWLMEQDKEQAVSYWDHYLSGHEQQTVLPKQKK TKGKSRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGS VISGRPAEIEGIEHMVGLFINTMPVRVQGAKTPFLQLIKDMQKDRLAAEAYSYHPLYE IQSRSAVKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLM VAPGEEIHIKMNYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIDITTDTEKRQ LIGEITDQTPVYETIHAMFEKQAEKTPDAHAVIDQACSLTYRELNKAANRLARHLRMK GVVRQEPVAIMMERSAAFITGVLGILKAGGAIVPVDPHYPADRIRYILHDCGCSHVVS QAHLPSSLEDNYIITHPEDIESKVDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEH RNMANLLKFEYTHSGIDFEADVLQFATPSFDVCYQEIFSALLKGGTLHIVPEAIKRDV PQLFAFINKHQTNIVFLPTAFIKMIFSERELANSFPDGVKHLIAAGEQLMISDLFQDV LRKRGIHLHNHYGPSETHVVSTYTIHPGDPIPELPPIGKPIGCTDLYILNHQKQLQPC GVPGELYISGASVARGYVNHDKLTSDKFSSDPFKPDVIMYRTGDLARRLEDGNIEYIG RADNQVKIRGYRIEPQEIEVTLMNHPDISEAAILIWQDQNGEHELCAYYCSVQKLNTI DLRSYMASELPEYMIPAKWIWVDSIPLTPNGKVDRAALPEPDASISGNPYTAPRNLLE AKLSQLFEDVLKNGHIGIQDNFFDNGGHSLKATVLMSRIAKEFHVQVSLKDIFAHPTV EGLALIIREAEQNLYAAIEPAEKRDTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEG ALDVAKLSAVCKELISRHEPLRTSFVSGADDEPVQRIHTEVPFTLSKETTIEGFVRPF DLSQAPLFRAGLIEVSNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQ YKDYAVWQQKFKKGDSYQKQETYWQQQFSGDLPILELPTDKRRPAERQFIGGKVTFQL DKEITARIKRLAHKNRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVL GMFVNTLALRTRPAGNKTFEEFLKEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNP LFDTTLVLQNMEQQKLKMNDVQLQWNDLEHPISKFDISLYVTEHDSELFCQFEYSTAL FEKETIQRWASLFTTLVEHTAASPETELDNIPILTKEEERDFIESCHLFEETGYSMNQ TLHYALEQQAEKTPDQAAVIFEDGVMTYKELNEQANRIAWELIGRGVKPETTVAIIGK RSPEMLLGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTNILLLQSAGLHVPEFTGE IVYLNQTNSGLAHRLSNPNVDVLPQSLAYVIYTSGSTGMPKGVEIEHRSAVNFLNSLQ SRYQLKHSDMIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKAIEEQK ITAMHFVPSMLHAFLEHIKYRSVPIKTNRLKRVFSGGEQLGTHLVSRFYELLPNVSIT NSYGPTEATVEAAFFDCPPHEKLERIPIGKPVHHVRLYLLNQNQRMLPVGCIGELYIA GAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIR GYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGY MVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKN GPVGIHDNFFDRGGHSLKATALVSRITKEFDVQVPLKDVFAHPTVEGLATVIREGTDS PYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFQ ELIKRHESLRTSFEQDEGGDPVQRIHDEVPFTLQTTVLGARTEQEAAAAFIKPFDLSQ APLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIQEFGELYNNRKLPALRIQYKDY AVWQEGFKTGDAYKMQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEV ASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFV NTLALRTRPEGGKPFVQYLQEVRETALEAFEHQNYPFEELVDKLELTRDMSRNPVFDA MLVVQNNDYEPLHLHDLQMKPAQVSHLVSKFDLTLQASEGDGNIHFLFEYSTALFEKT TIERWASHLTNVLSIIGKNPKVTLNHIDILTQEERHQLLNEFNTGQANQYGVQTISQL FEQQAARTPKASALVSGDKTLTYQELDEWSNGIARALRSRGVKPDTPVGIMMHRSFSM IASILGVWKAGGCYVPIDPEYPKERKRYILSDSGTKLLMTINEADLGVLADFEGEILT IESVEEDDKSPLPQMSSAHHLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFN ETDTILQLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMII VPVLYRALLDVVQPEDVKTLRVVTLAGEAADRELIARSLAICPHTELANEYGPTENSV ATTVMRHMEKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLP ELTERAFTQNPFKPEARMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESV IRCIKGVKDAAVVAHVTASGQTELSAYVVTKPGLSTNAVRSELQNKLPVFMHPAFIEK LDSLPLSPNGKLDRGALPKPVYNHEGERPFLPPSSKMEQILADIWKEVLGAEKIGTAD SFFELGGDSIKALQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEG DVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFT QNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRPYEPLIKRHVLDIQQKMDL KNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPK TSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISF TLNDKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLKG IDVSRTIGWFTAIYPLLIKLNADLPDSEESMVHVLKTTKDTLRRVPDKGFGYGVIKYL TPPGKKDINFTGAPEISFNYLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQS LDISAIAAEGKLTVNMTYDNARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISD FDDQELTEDALQEIADMLSFH*" gene complement(1825366..1836177) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" promotor_-35 1828386..1828389 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1828406..1828425 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1828407 /Source="Nicolas_upshifts" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1836202..1843869) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase C involved in synthesis of plipastatin" /protein_id="NP_389714.1" /db_xref="EnsemblGenomes-Gn:BSU18320" /db_xref="EnsemblGenomes-Tr:CAB13715" /db_xref="GOA:P39847" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10972" /db_xref="UniProtKB/Swiss-Prot:P39847" /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQ LDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKE HCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDF LHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTD QIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGS VISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYD IQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVI PGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIV SQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAA RGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLL TQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAV EHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEK DSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAA RFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHL AVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGN VEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQR NEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVT EMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPT VEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLEL EGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEE EAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYN NRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRS FAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAG RPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKL ELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRG LLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHEL NRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGV GPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSE KTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQR SVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQ LKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPE VSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGEL CVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQV KVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLL ARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIW QEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIR KSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKK LAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ QSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTI QLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKR DSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGRE HILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKY LTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMS AMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQ SLTAEDLDSISSLVEEL*" gene complement(1836202..1843869) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" CDS complement(1843886..1851568) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase B involved in synthesis of plipastatin" /protein_id="NP_389715.1" /db_xref="EnsemblGenomes-Gn:BSU18330" /db_xref="EnsemblGenomes-Tr:CAB13716" /db_xref="GOA:P39846" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10971" /db_xref="UniProtKB/Swiss-Prot:P39846" /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGN LCVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQE QQTLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILK EFFSMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRI KRRTADGNYKADQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDA VFGSVISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGY YPLYEIQNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNY DFNIVIVPGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPP EEQQVIQLFNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIA HALIEKGVGSGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQ AAQLLIEEDLISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKG VLVDHHGIANTLQWRREEYSMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDD EAKDVLALKRKIARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLE LNQIICPSAELANEYGPTENSVATTILRHLNKKERITIGHPIRNTKVFVLHGNQMQPI GAAGELCISGAGLARGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIG RFDDQVKIRGYRIELREIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLP DLYQHLAGTLPSYMIPASIINISQMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEA DLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVE SMAVKLMSLKEHAFTQIEPADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRG NLNRQRLRSVLTELVNRHEALRTVFVLDRDEPVQIIYPEMAFDLKELEMESEQMLESA IETFIKPFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGK ELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFR GGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRP HADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDT NREVNRNPLFDAMLVLQSSEDFRFEVPGLSISSVTPKHDISKFDLTLHAEEHLSGIRC RFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYA AYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDI VGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNKP ADYTGHILYIDECENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL LKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLL LKKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTD LINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGEL YIGGEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQV KVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRT YLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMA EIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETTVREMFEHQTLGELSA RVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVL KSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARNTIEEAA SRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSTAYKQAVS GESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDAASNTF KDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGH GRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIKQTKDMLHRIPHKG AGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVSDIKPGNEISPNWERPY ALDISGAVSSGCLNMHIIYNRFQFEEKTIQTFSRHFKQTLENIIEHCTGKENQEWSAS DFTDEDLTLDELSEIMGAVNKL*" gene complement(1843886..1851568) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" downshifts complement(1847557) /Source="Nicolas_upshifts" /id="D1002" /incds=1 /nref=2 /ntot=18 /MaxReadThrough="4.83331" /MaxDrop="4.93461" /score="20.5621533" /energy="-10.2" /TU="U1481,U1483" /idTUdmin="U1481" /TUdmin="-5742" /isTUend="FALSE" upshifts complement(1847601) /Source="Nicolas_upshifts" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" promotor_-10 complement(1847603..1847607) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1847625..1847628) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1847904..1847908 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1847921 /Source="Nicolas_upshifts" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1847924..1847943 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1851593..1859278) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 14762003, 16707694, 26284661, 26268540" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 14762003, 16707694, 26284661, 26268540; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase A involved in synthesis of plipastatin" /protein_id="NP_389716.2" /db_xref="EnsemblGenomes-Gn:BSU18340" /db_xref="EnsemblGenomes-Tr:CAB13717" /db_xref="GOA:P39845" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10970" /db_xref="UniProtKB/Swiss-Prot:P39845" /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELDT LEGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQD QASIPFKLFNSPLFQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKK KDPLPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQS TSASRDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGN RGSKAEKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNEL RNEQKDLHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQ LNFDYQNTLFSLEDIKRIQSHLLTILENALKHPHSFIRELDMTNTREKQKLLYEFNKT EAVSPKAFTLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNE SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCS APNFSGETLEVDMTSLASEKAENHEFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAV SFLTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIV QAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVL PQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSG VAGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGR TDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQ LERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQ LWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLAT VIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNP ERMERAFKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAF IKPFDLSQAPLFRAQIVKISDERHLLLVDMHHIISDGVSVNILIREFGELYNNRNLPA LRIQYKDYAVWREGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKV SFTLDQEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDL EPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDM SRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEF STEVFLKATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFA QKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAV LAKRSIDAIVGVLAVMKAGGVYIPIDAHYPKARIEYILRDSGADILLLQRELKHLISN SPESEMSHIFLDDEGSFEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNFTH AALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEIY KIIKSQRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG QSMRIINSYGVTEATIDSSFYETSMGGECTGDNVPIGSPLPNVHMYVLSQTDQIQPIG VAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGR MDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNAL RAALTKELPAYMIPAYLIPLVNMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDLQKTM AYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELC GHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHL ALRKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDE KLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAA YQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKTYWQTILDAHTAFLPKDIE NVPDKLQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQI VISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRR VPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEVETFQLSYYQPRYEIAGERER EYELDINALITDGRLHVKAVYTQVFSKHSIECFMDRFHRHLIETIEHCSQKKAREKTL SDFSNKELTLSALSSIEDLVKDL*" gene complement(1851593..1859278) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" S_feature complement(1859279..1859387) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1859372..1859391) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859387) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" promotor_-35 complement(1859405..1859412) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1859661..1861136) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" gene complement(1859661..1861136) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" downshifts complement(1859673) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" CDS complement(1861170..1862147) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" gene complement(1861170..1862147) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" promotor_-10 complement(1862176..1862194) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1862188) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" promotor_-35 complement(1862206..1862214) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1862281..1863672) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" gene complement(1862281..1863672) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" downshifts complement(1862295) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" downshifts 1862441 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" promotor_-35 1863462..1863468 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1863482..1863500 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1863493..1863826 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1863493 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" S_feature complement(1863673..1863777) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1863737..1863837) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1863777) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" promotor_-35 1863799..1863804 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1863820..1863838 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1863828 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" promotor_-35 1863886..1863893 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1863906..1863925 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1863909 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" CDS 1863958..1864503 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" gene 1863958..1864503 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" downshifts 1864487 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" tRNA complement(1864597..1864669) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(1864597..1864669) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" downshifts complement(1864695) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" CDS complement(1864722..1865267) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" gene complement(1864722..1865267) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" promotor_-10 complement(1865307..1865326) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1865321) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" promotor_-35 complement(1865340..1865347) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1865583..1865813) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" gene complement(1865583..1865813) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" downshifts complement(1865597) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1865839..1865858) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1865851) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" promotor_-35 complement(1865870..1865876) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1865905..1865924) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1865915) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1865928..1865935 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1865949..1865968 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1865953 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" CDS 1865998..1867761 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" gene 1865998..1867761 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" downshifts 1867742 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" CDS complement(1867862..1868719) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" gene complement(1867862..1868719) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" promotor_-10 complement(1868765..1868784) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1868785) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" promotor_-35 complement(1868798..1868805) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1868847..1869836 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" gene 1868847..1869836 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" S_feature complement(1868903..1869861) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1869893..1871374) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" gene complement(1869893..1871374) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" downshifts complement(1869906) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" CDS complement(1871391..1875953) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" gene complement(1871391..1875953) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" promotor_no_box 1874414..1874514 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1874474 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(1875954..1876025) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1876005..1876024) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1876022..1876029 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1876025) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" promotor_-35 complement(1876039..1876046) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1876041 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" promotor_-10 1876044..1876063 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1876100..1877002 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" gene 1876100..1877002 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" downshifts 1876982 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" CDS complement(1877054..1878169) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" gene complement(1877054..1878169) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" CDS complement(1878166..1879059) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" gene complement(1878166..1879059) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" promotor_-10 complement(1879064..1879083) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1879072 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" upshifts complement(1879082) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" promotor_-35 complement(1879097..1879103) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1879112..1879130) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1879130) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" promotor_-35 complement(1879146..1879151) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1879207..1879575) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" gene complement(1879207..1879575) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" promotor_-10 complement(1879610..1879628) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1879633) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" S_feature complement(1879635..1879754) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1879640..1879648) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1879746..1879765) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1879754) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" S_feature complement(1879756..1879852) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1879780..1879787) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1879875..1880591) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" gene complement(1879875..1880591) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" downshifts complement(1879897) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" promotor_-10 complement(1880629..1880648) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1880638) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" promotor_-35 complement(1880664..1880667) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1880692..1880698 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1880712..1880730 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1880717 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" CDS 1880742..1881047 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " gene 1880742..1881047 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" downshifts 1881031 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" CDS 1881118..1881888 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" gene 1881118..1881888 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" promotor_-35 1881870..1881877 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1881889 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" promotor_-10 1881892..1881911 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1881932..1882465 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" gene 1881932..1882465 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" S_feature 1882466..1882551 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1882508 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" CDS complement(1882544..1883788) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" gene complement(1882544..1883788) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" S_feature 1882553..1883292 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1882558) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" S_feature complement(1883789..1883881) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1883882..1885345) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" gene complement(1883882..1885345) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" CDS complement(1885363..1886397) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" gene complement(1885363..1886397) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" S_feature complement(1886409..1886480) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1886452) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" misc_RNA complement(1886481..1886572) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(1886481..1886572) /gene="mswF" /locus_tag="BSU_misc_RNA_31" promotor_-10 complement(1886600..1886619) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1886612) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" promotor_-35 complement(1886634..1886641) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1886654..1886661 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1886675..1886694 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1886679 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" CDS 1886721..1888763 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" gene 1886721..1888763 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" promotor_-35 1888771..1888780 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1888793..1888808 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1888796 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" CDS 1888830..1889123 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" gene 1888830..1889123 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" downshifts 1889103 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" S_feature complement(1889148..1889495) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1889179) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" CDS complement(1889496..1889900) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" gene complement(1889496..1889900) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" S_feature complement(1889901..1889996) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1889986..1890001) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1889986..1890105) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" gene complement(1889986..1890105) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" upshifts complement(1889996) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" promotor_-35 complement(1890014..1890023) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1890101..1890107 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1890121..1890132 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1890132..1890340 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1890132 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" CDS 1890175..1890297 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" gene 1890175..1890297 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" CDS 1890341..1890634 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" gene 1890341..1890634 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" S_feature 1890635..1890728 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1890685 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" CDS complement(1890750..1892435) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" gene complement(1890750..1892435) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" downshifts complement(1890762) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" S_feature complement(1892436..1892523) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1892515..1892533) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1892523) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" promotor_-35 complement(1892547..1892554) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1892692..1892701 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1892711 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" promotor_-10 1892714..1892733 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1892760..1894211 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" gene 1892760..1894211 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" downshifts 1894187 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" CDS complement(1894248..1894946) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" gene complement(1894248..1894946) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" downshifts complement(1894263) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" promotor_-10 complement(1894981..1895000) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1895000) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" S_feature complement(1895002..1895215) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1895014..1895021) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1895216..1895893) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" gene complement(1895216..1895893) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" S_feature complement(1895894..1898383) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1896066..1897103 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" gene 1896066..1897103 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" promotor_-35 1897300..1897306 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1897321..1897332 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1897333 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" CDS 1897360..1898043 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" gene 1897360..1898043 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" CDS complement(1898384..1898689) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " gene complement(1898384..1898689) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" S_feature complement(1898690..1898791) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1898770..1898789) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1898791) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" promotor_-35 complement(1898804..1898811) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1898819..1898921) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1898861) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" CDS complement(1898922..1900100) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" gene complement(1898922..1900100) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" promotor_-10 complement(1900126..1900145) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1900145) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" promotor_-35 complement(1900159..1900168) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1900223..1900711) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" gene complement(1900223..1900711) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" downshifts complement(1900248) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" CDS complement(1900736..1900891) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" gene complement(1900736..1900891) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" CDS complement(1900931..1901686) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" gene complement(1900931..1901686) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" promotor_-35 1901939..1901944 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1901960..1901978 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1901975 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" CDS 1901994..1902350 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" gene 1901994..1902350 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" CDS complement(1902309..1902548) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" gene complement(1902309..1902548) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" S_feature 1902351..1902787 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1902549..1902650) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1902651..1903148) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" gene complement(1902651..1903148) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" S_feature complement(1903149..1903248) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1903249..1904160) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" gene complement(1903249..1904160) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" promotor_-10 complement(1904182..1904193) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1904184) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" promotor_-35 complement(1904208..1904214) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1904444..1904451 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1904460 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" promotor_-10 1904466..1904485 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1904507..1904989 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" gene 1904507..1904989 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" CDS 1904999..1905253 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" gene 1904999..1905253 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" S_feature 1905254..1905358 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1905359..1906153 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" gene 1905359..1906153 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" S_feature 1906154..1907164 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1906277..1907149) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" gene complement(1906277..1907149) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" CDS 1907250..1908128 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" gene 1907250..1908128 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" S_feature complement(1908241..1908300) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1908276) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" CDS complement(1908301..1908732) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" gene complement(1908301..1908732) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" promotor_-10 complement(1908752..1908771) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1908760) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" S_feature complement(1908762..1908995) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1908785..1908791) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1908996..1909014) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1908996..1909628) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" gene complement(1908996..1909628) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" upshifts complement(1909002) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" promotor_-35 complement(1909030..1909035) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1909766..1909773 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1909788..1909807 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1909792 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" CDS 1909854..1910774 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" gene 1909854..1910774 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" promotor_-10 complement(1910285..1910304) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1910300) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1910319..1910326) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1910775..1911432 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1911271..1911633) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" gene complement(1911271..1911633) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" CDS complement(1911694..1911906) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" gene complement(1911694..1911906) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo promotor_-35 1911945..1911952 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1911967..1911986 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1911970 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" CDS 1912010..1912273 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" gene 1912010..1912273 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" downshifts 1912251 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" CDS complement(1912650..1915250) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" gene complement(1912650..1915250) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" S_feature complement(1915251..1915360) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1915276..1915283 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1915298..1915317 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1915306..1915933 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1915306 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" promotor_-10 complement(1915350..1915369) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915360) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" promotor_-35 complement(1915384..1915390) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1915406..1915865) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1915448) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" downshifts complement(1915910) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" CDS complement(1915920..1916561) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" gene complement(1915920..1916561) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" S_feature complement(1916562..1916679) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1916656..1916675) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1916679) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" promotor_-35 complement(1916689..1916691) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1917189..1917428) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097736.1" /db_xref="EnsemblGenomes-Gn:BSU18849" /db_xref="EnsemblGenomes-Tr:CAX52631" /db_xref="GOA:C0H423" /db_xref="InterPro:IPR007829" /db_xref="UniProtKB/Swiss-Prot:C0H423" /translation="MVSKKNKIVAALLAFFFGGLGIHKFYLGRVGQGILYILFCWTGI PSIIAFIEFIIFLCGSEEGFDQKYNFYYFQQQSKA*" gene complement(1917189..1917428) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" downshifts complement(1917209) /Source="Nicolas_upshifts" /id="D1030" /incds=0 /nref=31 /ntot=127 /MaxReadThrough="3.22282" /MaxDrop="3.97488" /score="-1.08247697" /energy="-4.5" /TU="U1526" /idTUdmin="U1526" /TUdmin="-529" /isTUend="FALSE" misc_feature complement(1917468..1917487) /Source="Nicolas_upshift_promotors" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1917475) /Source="Nicolas_upshifts" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" promotor_-35 1917534..1917541 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1917556..1917575 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1917563 /Source="Nicolas_upshifts" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" CDS 1917599..1917937 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10376821" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="transcriptional regulator (phage-related, Xre family); putative defective prophage 6" /protein_id="NP_389766.1" /db_xref="EnsemblGenomes-Gn:BSU18850" /db_xref="EnsemblGenomes-Tr:CAB13777" /db_xref="GOA:O34647" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG13497" /db_xref="UniProtKB/Swiss-Prot:O34647" /translation="MYCQRLRQLRKAHKLTMEQLAEKIGIAKSSYGGYEAESKKPPLD KLVILARLYDVSVDYILGLTDDPDPKVERKNLKEFLEKPDIHWDGYKLTPEILDPIRK ILKLVTANNN*" gene 1917599..1917937 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" S_feature 1917938..1918534 /Source="Nicolas_S_feature" /locus_tag="new_2056617_2057213" /HighExp="M0t90, Lbstat, Lbtran, MG 150, M40t90, MG 15, SMM, GM 25, Fru, GM-0.1" /AntisenseName="yozH" /AntisenseCor="0.41013265801279702" /AntisenseRegPval="-11.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S711" CDS complement(1917971..1918327) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="NP_389767.2" /db_xref="EnsemblGenomes-Gn:BSU18860" /db_xref="EnsemblGenomes-Tr:CAB13778" /db_xref="SubtiList:BG13755" /db_xref="UniProtKB/Swiss-Prot:O31837" /translation="MNDLLFAAGNLHIGLGHDYLKCIALLINVKRFFSLTESYGNISD KLAVVAMKGVQFDQFEEAYKAYKETVAINQNSLVDFLSALITLIKAGEKLQKAGESLA IIMNKLLEMSPENSMK*" gene complement(1917971..1918327) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" CDS 1918535..1918900 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative defective prophage 6" /protein_id="NP_389768.1" /db_xref="EnsemblGenomes-Gn:BSU18870" /db_xref="EnsemblGenomes-Tr:CAB13779" /db_xref="SubtiList:BG13756" /db_xref="UniProtKB/Swiss-Prot:O31838" /translation="MPKLYTCLICGYKGLIQNPLNNDGEYQKTFDICPCCDFEYGYSE DHDVSLGFIVTPDYLIDAAIQLYRKQWIENGMKTANPEDIPEELRNGDCLKFEVLLKQ LNSLNLDTENFEIKGFNGY*" gene 1918535..1918900 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" S_feature complement(1918909..1920035) /Source="Nicolas_S_feature" /locus_tag="new_2057588_2058714_c" /HighExp="BC, Sw, HiOs, C90, Lbstat, M0t90, UNK1, M9-stat, HiTm, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig="0.994" /label="S712" downshifts complement(1918952) /Source="Nicolas_upshifts" /id="D1031" /incds=0 /nref=3 /ntot=99 /MaxReadThrough="3.80479" /MaxDrop="4.2268" /score="22.3776508" /energy="-7.6" /TU="U1528" /idTUdmin="U1528" /TUdmin="-513" /isTUend="FALSE" CDS 1919122..1919781 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative SOS response associated phage protein; putative defective prophage 6" /protein_id="NP_389769.1" /db_xref="EnsemblGenomes-Gn:BSU18880" /db_xref="EnsemblGenomes-Tr:CAB13780" /db_xref="GOA:O34915" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13498" /db_xref="UniProtKB/Swiss-Prot:O34915" /translation="MCGKFTLFSEFDDIIEQFNIDQFLPEGEYHPSYNVAPSQNILTI INDGSNNRLGKLRWGLIPPCAKDEKIGYKMINARAETLAEKPSFRKPLGSKRCIIPAD SFYEWKRLDPKTKIPMRIKLKSSNLFAFAGLYEKWNTLEGNLLYTCTIITIKPSELME DIHDRMPVILTDENKKEWLNPKNTDPDYLQSLLLPYDADDMEAYQVSSLVNSPELIES H*" gene 1919122..1919781 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" downshifts 1919859 /Source="Nicolas_upshifts" /id="D1032" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="1.22982" /MaxDrop="2.96245" /score="5.95470205" /energy="-19.6" /TU="NA" /idTUdmin="U1527" /TUdmin=990 /isTUend="FALSE" CDS complement(1920036..1920959) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389770.1" /db_xref="EnsemblGenomes-Gn:BSU18890" /db_xref="EnsemblGenomes-Tr:CAB13781" /db_xref="SubtiList:BG13499" /db_xref="UniProtKB/Swiss-Prot:O34780" /translation="MLVYIGNGHYCYSNSTAMFLSSIGENVSPQLVEILTGVGLGAMI EYEKNLYFSMRDPDDGINYALNILGFTAEEHQQASDLDDPFPLLKQQIKQNPVILGPL DMGELTYHPNHKNLNGSDHYVLGYQMDNENIYVQDPAGFPFVPLSLDQFKKAWMAERI PYRKGINKYWSTAKKVVTLDNNEIYERAIDYFKRTYRKFEKVDIGLIGREAICFYADQ LLNAPITADTIRHTTFFLFQLSARRANDYAMYFKDRHSHLSVLKTEQAKVFGICHSMS VNKDWKGISEKLMKLADLEDNFRLELLKVGY*" gene complement(1920036..1920959) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" promotor_-10 complement(1920815..1920834) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1920818) /Source="Nicolas_upshifts" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" promotor_-35 complement(1920846..1920853) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1920970..1920989) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-10" upshifts complement(1920991) /Source="Nicolas_upshifts" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" promotor_-35 complement(1921004..1921011) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-35" CDS complement(1921012..1921185) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="YP_003097737.1" /db_xref="EnsemblGenomes-Gn:BSU18898" /db_xref="EnsemblGenomes-Tr:CAX52632" /db_xref="UniProtKB/Swiss-Prot:C0H424" /translation="MTEIKANSTVMIHVLADETLSSIKREYVEVDRKTEIGEKIIIVD KNDPDDEYENGAI*" gene complement(1921012..1921185) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" CDS 1921330..1921554 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097738.1" /db_xref="EnsemblGenomes-Gn:BSU18899" /db_xref="EnsemblGenomes-Tr:CAX52633" /db_xref="UniProtKB/Swiss-Prot:C0H425" /translation="MNFLLDLFTNWTFDKVLDYTLAAVIWSVFKSRSKQNKYPGYFEK IRRYRNLHPLLRSLSMRVLLSITIHPYMFS*" gene 1921330..1921554 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" CDS complement(1921558..1922013) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389771.1" /db_xref="EnsemblGenomes-Gn:BSU18900" /db_xref="EnsemblGenomes-Tr:CAB13782" /db_xref="SubtiList:BG13757" /db_xref="UniProtKB/Swiss-Prot:O31839" /translation="MADRYVLIEVNEDGEGRLKDEAVTWIDFRLSIVDFNASEGLNQL MEQISKDVKDELVLVLFNYRVKSSYDSWSGATEYEDFFDVEFFKVIKKNYKKFYQGLV TVELDVGINGFDNIESMPTDSNQNYYRNLIAEWEEFYNEDFIPLSLNKR*" gene complement(1921558..1922013) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" promotor_-35 1922073..1922080 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1922095..1922114 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1922099 /Source="Nicolas_upshifts" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" CDS 1922138..1922398 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="YP_003097739.1" /db_xref="EnsemblGenomes-Gn:BSU18908" /db_xref="EnsemblGenomes-Tr:CAX52634" /db_xref="UniProtKB/Swiss-Prot:C0H426" /translation="MNLRKILLSSALSLGMLVSAAPVLATSSSSEVIVKSDEYDYDTI YQLSPLPNFKPSIEYNGYTYTLTRYYFDYSIQFYTAIYTKVV*" gene 1922138..1922398 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" downshifts 1922345 /Source="Nicolas_upshifts" /id="D1033" /incds=0 /nref=1 /ntot=221 /MaxReadThrough="4.57606" /MaxDrop="3.58254" /score="4.613667" /energy="-8.7" /TU="U1530" /idTUdmin="U1530" /TUdmin="-638" /isTUend="FALSE" promotor_-35 1922813..1922816 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1922830..1922849 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1922847 /Source="Nicolas_upshifts" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1922959 /Source="Nicolas_upshifts" /id="D1034" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="3.18248" /MaxDrop="3.66335" /score="32.4789235" /energy="-13.7" /TU="U1530,U1531" /idTUdmin="U1530" /TUdmin="-24" /isTUend="FALSE" CDS 1923176..1923316 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage holin (fragment)" /db_xref="PSEUDO:CAX52635.1" /translation="MTVFGDDLTEKFNALLTFLTALGIIVDPTTQGISDSEQAMDYDS PR*" gene 1923176..1923316 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /pseudo downshifts 1923313 /Source="Nicolas_upshifts" /id="D1035" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.30104" /MaxDrop="4.04304" /score="32.4789235" /energy="-13.7" /TU="NA" /idTUdmin="U1531" /TUdmin=242 /isTUend="FALSE" promotor_-35 1923398..1923405 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1923417..1923436 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1923418 /Source="Nicolas_upshifts" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" CDS 1923471..1924586 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:16816200, 25225273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 25225273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_389772.1" /db_xref="EnsemblGenomes-Gn:BSU18910" /db_xref="EnsemblGenomes-Tr:CAB13783" /db_xref="GOA:O34930" /db_xref="InterPro:IPR011990" /db_xref="SubtiList:BG12664" /db_xref="UniProtKB/Swiss-Prot:O34930" /translation="MSKIASEVVATTLNDWYIAIKKQKVDESIKYYSEIKKLFDEMEE DQEVLAYYSLLEERHKMLLHSSRGEPLQKHTYFTEDNQNFITKTNDKLEYNFYLFEAM YEAYNKNYDRAINLYGLAEKKLAEIPDEIEAAEFYSKVSYLYTLVKQSIVAQHYIKNA ISIYKRHPDYKCKLATSTMIAAANYADMKRFEEAEQYYLEAIDIAKETKDEFLKAQLF HNLSIVYSDWNKPDKCIESLEKAIGNESWLHSIYYINSLFMMIKELFKIDEKMKAINF YNKAQERLILMENKVYEAKISILYNLYCGELKNNFNNCISNIEFLKQQNELESVDELS YIAAKRFESIGAFEEATSFFNAKIWAEQKMNQVEGIL*" gene 1923471..1924586 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" promotor_-35 1924310..1924318 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1924327 /Source="Nicolas_upshifts" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" promotor_-10 1924330..1924348 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1924583..1924705 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11587781, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11587781, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapK" /protein_id="NP_389773.1" /db_xref="EnsemblGenomes-Gn:BSU18920" /db_xref="EnsemblGenomes-Tr:CAB13784" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG12646" /db_xref="UniProtKB/Swiss-Prot:O31840" /translation="MKKLVLCVSILAVILSGVALTQLSTDSPSNIQVAERPVGG*" gene 1924583..1924705 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" downshifts 1924699 /Source="Nicolas_upshifts" /id="D1036" /incds=0 /nref=232 /ntot=252 /MaxReadThrough="2.33184" /MaxDrop="6.45227" /score="9.89565332" /energy="-10.4" /TU="NA" /idTUdmin="U1532" /TUdmin=0 /isTUend="TRUE" CDS complement(1924831..1925484) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative DNA phage repair protein; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18930" /db_xref="EnsemblGenomes-Tr:CAB13785" /db_xref="GOA:C0SPA8" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="PSEUDO:CAB13785.2" /db_xref="SubtiList:BG13500" /db_xref="UniProtKB/Swiss-Prot:C0SPA8" /translation="MAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIA RWRYEDVPNRLWKVRPLSKMWGIGGRMERNLNRMGISTVGQLAKFPLELLEKKFGIMG NQLYYHAHGIDLSEIGAPLMQGQISFGKSQILFRDYTKREEIKAVLLEICEEVARRAR TYNKVGRTISLGIGYSKDELGGGFHRSKTIDFPTNITMDIYKCCLMFFNKFYSGKKQ* " gene complement(1924831..1925484) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /pseudo downshifts complement(1925105) /Source="Nicolas_upshifts" /id="D1037" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="1.36944" /MaxDrop="2.50062" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin=1628 /isTUend="FALSE" CDS complement(1925521..1925868) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /function="16.9: Replicate" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12137951; Product type h: extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage DNA repair protein fragment; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18940" /db_xref="EnsemblGenomes-Tr:CAB13786" /db_xref="GOA:O31841" /db_xref="InterPro:IPR001126" /db_xref="PSEUDO:CAB13786.1" /db_xref="SubtiList:BG13758" /db_xref="UniProtKB/Swiss-Prot:O31841" /translation="MTDYSQFPRENILCVDMKSFYASVSAVAMGLNPLTCYLAVVGNT DRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIYIVNPQMKLFIRVSTEITKLFYR FVPEKCVHTYSID*" gene complement(1925521..1925868) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /pseudo CDS complement(1925861..1926154) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /function="16.6: Maintain" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein of phage origin; putative defective prophage 6" /protein_id="NP_389776.1" /db_xref="EnsemblGenomes-Gn:BSU18950" /db_xref="EnsemblGenomes-Tr:CAB13787" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG13759" /db_xref="UniProtKB/Swiss-Prot:O31842" /translation="MMLEQLIQLKQDLIDGSKVEKPSLDDKQIDEMDILVSEALEFNK ELKFKLFNKGFVENVTGRVHYINFEQQKLHVKDQNDNTVYINMNNIIRVIYND*" gene complement(1925861..1926154) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" upshifts 1926305 /Source="Nicolas_upshifts" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" misc_feature 1926306..1926325 /Source="Nicolas_upshift_promotors" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1926363..1926698 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative bacteriophage protein; putative defective prophage 6" /protein_id="NP_389777.1" /db_xref="EnsemblGenomes-Gn:BSU18960" /db_xref="EnsemblGenomes-Tr:CAB13788" /db_xref="SubtiList:BG13760" /db_xref="UniProtKB/Swiss-Prot:O31843" /translation="MKKRLIGFLVLVPALIMWGITLIESNKKTPVEVLESAWDEFGLF SFEIGITDPAITIGMDQTKSEAKLREYLKDNLSREAKEKYKIYIFKDDTDKLEKEHQE YLKENNLNK*" gene 1926363..1926698 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" promotor_no_box complement(1926737..1926837) /Source="Nicolas_upshift_promotors" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(1926744) /Source="Nicolas_upshifts" /id="D1038" /incds=0 /nref=148 /ntot=238 /MaxReadThrough="2.4012" /MaxDrop="4.9328" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin="-11" /isTUend="TRUE" CDS complement(1926745..1930350) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15128444; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage repair NTPase with transmembrane helices; putative defective prophage 6" /protein_id="NP_389778.1" /db_xref="EnsemblGenomes-Gn:BSU18970" /db_xref="EnsemblGenomes-Tr:CAB13789" /db_xref="GOA:O34784" /db_xref="InterPro:IPR011646" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13501" /db_xref="UniProtKB/Swiss-Prot:O34784" /translation="MGEIKKKFVQWLEKLLIRLKEPNVKEESLFEDLSPSNDVDTDGK YSKALSWGLENKKVKNIALTGPYGSGKSSILNTFQKQYSREYSFLNISLATFNTDTDD MENKLEKSILQQMIYRVHDRTIPFSRFKRIKHIRTKSIIINLIFFFAFIIVGIYLFKP DALKGIYAETLVSRSLGTEDQQQIRLTILLALFFIVYPLLAYKRIYHFVRANLKLNKV TIANTTLEKNTGEENSSIFDKYLDEILYFFEASKYNVVIFEDLDRFNNIGIFERLREL NELINNSEQIDRRVVFIYAIKDDIFGDADTEKLTRDRTKFFDFIIPVIPIINASNSGD ILKKKIKHSPYSDLINTHFLEDVTIYIDDMRVLKNIFNEFVIYQQKLSAIDLDPNKML AMIIYKNIYPVDFSKLQYNKGLVYEIFQKKQLIIEEQIKLINAKIQQLERKLANIEVE SLKSIAELNFIYLSELEISNLNSNYDINIDGEVFRGNTSNKDRFFEKLKNADTIYCYL RNRNGPATIKEIATVFGRKPNYFEREDAIKAIEKNEIQKFKKELLELEREKQEIRAQS LQVLITKMNSKDVFSDKLYEKKLLVYLLRHGYIDEMYNHYITYFYPESLSLSDIKFVF SIKNHESLPYSFELDNIGKIMSKLVGAEFKQIEVLNFHLLNYIMDHSEYRNYYDSIIE RLANGSKESVTFIDGFKERAINKAAFIQSISSKWDDFWSFIELRSNYTQQKKEEYLSD ILTYADIADIIRMNKESVMSFTLSKYLNLLSLVSDEEKIKELLLKLQVKFKSLDHLLN SETIYDFVVQRNLYEINIKTLSVILNDAPNITYAAVKNSDQQAVINYVNDNIDIFVEK VLLTEEIEEPEESFLELLNREDLDKRVKHAMIMKKTFAISDIGELIKELWPIVIRENK MVACWSNVITSYVEYNKKMPDFLIAFLNNPVNRKELSKNNIEAFDDKFDEAILEDISE EIINSRDITDETFEVLIASIQSWIYFPLGNVSEKRAKLLIDNDLLSLTPENFKELKLN FDTLHIQLALRNPDEFIDKQGDFSLDANDIKQLIDSNELSQFNKEIFVQHLNSNCLTD GNNDILKDTIYFINEHNLKITNELLTFLLESPTTLDTRLSLLAGQIKHIDNESITEFL TKIGEPYSEIAEKGRRIKISNNRTNKALVTALESKNYISSFKEDRERLRVNTKKK*" gene complement(1926745..1930350) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" upshifts complement(1926777) /Source="Nicolas_upshifts" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(1930351..1930495) /Source="Nicolas_S_feature" /locus_tag="new_2069030_2069174_c" /HighExp="LBGstat, Lbstat, M0t90, T3.0H, T1.30H, T3.30H, MG 150, T2.30H, T4.0H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.936" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S713" misc_feature complement(1930488..1930507) /Source="Nicolas_upshift_promotors" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1930495) /Source="Nicolas_upshifts" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" S_feature complement(1930497..1930582) /Source="Nicolas_S_feature" /locus_tag="new_2069176_2069261_c" /HighExp="LBGstat, C30, Lbstat, M0t90, GM 120, GM 25, GM 150, nit, GM 90, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S714" CDS complement(1930583..1930882) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative fragment of phage protein; putative defective prophage 6" /db_xref="PSEUDO:CAX52636.1" /translation="MATEGYGGNNSAPSRSIGFSEFCETLEKNEVVKPENKKSSLDLN NSLDYWKSRFNPGGNLSALDSQVLDIIKKAYNLGMVNKDNMLLRNEAINAYKNSI*" gene complement(1930583..1930882) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /pseudo S_feature complement(1930883..1931020) /Source="Nicolas_S_feature" /locus_tag="new_2069562_2069699_c" /HighExp="LBGstat, C30, MG 150, GM 150, M0t90, Lbstat, GM 25, GM 90, GM 120, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S715" promotor_-10 complement(1930998..1931016) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931020) /Source="Nicolas_upshifts" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" promotor_-35 complement(1931030..1931036) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(1931053..1931436) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /product="small regulatory antitoxin RNA, toxin-antitoxin type I system (BsrE/AsrE)" /experiment="publication(s) with functional evidences, PMID:18948176, 23059907, 24576839, 26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23059907, 24576839, 26565032, 26940229; Product type n: RNA" gene complement(1931053..1931436) /gene="asrE" /locus_tag="BSU_misc_RNA_74" S_feature complement(1931067..1931303) /Source="Nicolas_S_feature" /locus_tag="new_2069746_2069982_c" /HighExp="Salt, Etha, S4, LoTm, dia5, Diami, S5, MG 120, S3, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S716" promotor_-35 1931100..1931102 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1931110) /Source="Nicolas_upshifts" /id="D1039" /incds=0 /nref=39 /ntot=216 /MaxReadThrough="3.37292" /MaxDrop="5.0558" /score="17.2005818" /energy="-10" /TU="U1541" /idTUdmin="U1539" /TUdmin=1 /isTUend="TRUE" promotor_-10 1931118..1931137 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1931123 /Source="Nicolas_upshifts" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" S_feature 1931145..1931298 /Source="Nicolas_S_feature" /locus_tag="new_2069824_2069977" /HighExp="T1.30H, B60, T2.0H, M9-stat, BT, T0.30H, B36, T1.0H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87861900000000004" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S717" CDS 1931204..1931296 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /experiment="publication(s) with functional evidences, PMID:26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26565032, 26940229; Product type f: factor" /codon_start=1 /transl_table=11 /product="type I toxin (BsrE/AsrE)" /protein_id="YP_009513965.1" /translation="MSTFQALMLMLAIGSFIIALLTYIEKIDLP*" gene 1931204..1931296 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" downshifts 1931255 /Source="Nicolas_upshifts" /id="D1040" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="6.71009" /MaxDrop="3.13767" /score="33.1812693" /energy="-14.4" /TU="U1538" /idTUdmin="U1538" /TUdmin="-66" /isTUend="FALSE" S_feature complement(1931305..1931439) /Source="Nicolas_S_feature" /locus_tag="new_2069984_2070118_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, S4, M9-stat, T-1.10H, S7, B60, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S718" downshifts 1931321 /Source="Nicolas_upshifts" /id="D1041" /incds=0 /nref=135 /ntot=196 /MaxReadThrough="2.41468" /MaxDrop="5.72925" /score="33.1812693" /energy="-14.4" /TU="NA" /idTUdmin="U1538" /TUdmin=0 /isTUend="TRUE" downshifts complement(1931348) /Source="Nicolas_upshifts" /id="D1042" /incds=0 /nref=13 /ntot=114 /MaxReadThrough="6.34283" /MaxDrop="4.1536" /score="3.24083135" /energy="-14.3" /TU="U1539,U1541" /idTUdmin="U1539" /TUdmin="-237" /isTUend="FALSE" upshifts complement(1931439) /Source="Nicolas_upshifts" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" S_feature complement(1931441..1931564) /Source="Nicolas_S_feature" /locus_tag="new_2070120_2070243_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, T-1.10H, T1.0H, T-1.40H, Etha, SMMPr, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S719" misc_feature complement(1931448..1931449) /Source="Nicolas_upshift_promotors" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(1931565..1932407) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11866510" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function; putative defective prophage 6" /protein_id="NP_389779.1" /db_xref="EnsemblGenomes-Gn:BSU18980" /db_xref="EnsemblGenomes-Tr:CAB13790" /db_xref="GOA:O34774" /db_xref="SubtiList:BG13502" /db_xref="UniProtKB/Swiss-Prot:O34774" /translation="MELLDIWNWIQQNGILTAVITGIVALLFNQRQKSIERFYSQSGE TLEKILEPMYYSLKEIKNEEDENHKMVLIEKFFEEYSGKKGKLSKLRNILLIDQILNT EDCFREYILNKNSENRKKLFYKMRMLDQAVNKEYRSIFVTLNKNYNWYKVLFRTNYIL SAVFVFVRWFKETLAFFVGASAFAFIPLLYDKYLGEQVLGNWLEVNKLIFGLSCSALY IFWIIHYFLLKDTMQRKDEISLFQEWFDKTKLGKWTNKNVWGKIGNWNVERRARRVRN DEDV*" gene complement(1931565..1932407) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" promotor_-35 1931902..1931905 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1931915 /Source="Nicolas_upshifts" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1931921..1931925 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1932433..1932448) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-10" upshifts complement(1932434) /Source="Nicolas_upshifts" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" S_feature complement(1932436..1932518) /Source="Nicolas_S_feature" /locus_tag="new_2071115_2071197_c" /HighExp="MG 150, T-3.40H, Cold, SMM, Lbstat, SMMPr, ferm, T-2.40H, Fru, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S720" promotor_-35 complement(1932460..1932469) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-35" S_feature complement(1932520..1932606) /Source="Nicolas_S_feature" /locus_tag="new_2071199_2071285_c" /HighExp="Lbstat, M0t90, HiOs, HiTm, M40t90, dia15, S2, S1, T-0.40H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S721" downshifts complement(1932563) /Source="Nicolas_upshifts" /id="D1043" /incds=0 /nref=5 /ntot=191 /MaxReadThrough="4.07519" /MaxDrop="4.09712" /score="-3.79237769" /energy="-8.4" /TU="U1542" /idTUdmin="U1542" /TUdmin="-110" /isTUend="FALSE" CDS complement(1932607..1933065) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /function="17.2: Prophage functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin inhibiting Rnase RttL" /protein_id="NP_389780.1" /db_xref="EnsemblGenomes-Gn:BSU18990" /db_xref="EnsemblGenomes-Tr:CAB13791" /db_xref="InterPro:IPR018958" /db_xref="PDB:2PRV" /db_xref="SubtiList:BG13503" /db_xref="UniProtKB/Swiss-Prot:O34596" /translation="MIYSKVENFINENKQNAIFTEGASHENIGRIEENLQCDLPNSYK WFLEKYGAGGLFGVLVLGYNFDHASVVNRTNEYKEHYGLTDGLVVIEDVDYFAYCLDT NKMKDGECPVVEWDRVIGYQDTVADSFIEFFYNKIQEAKDDWDEDEDWDD*" gene complement(1932607..1933065) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" CDS complement(1933075..1934877) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phage toxin ribonuclease; putative defective prophage 6" /protein_id="NP_389781.1" /db_xref="EnsemblGenomes-Gn:BSU19000" /db_xref="EnsemblGenomes-Tr:CAB13792" /db_xref="GOA:O34330" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR026834" /db_xref="SubtiList:BG13504" /db_xref="UniProtKB/Swiss-Prot:O34330" /translation="MKVFEADSLLFEADKRTKEYKELRSQMVKLKKAFKEVANLDDSE FSGKGADNIKAFYHGHVGVTDQWIDLIDMKIAFLSSMSATLEDAKMSDAYIEESFLEH ELANAYAKSKSIMSEQKKAMKDILNNINDILPLEIFSTEDFKDKLSSADDKREKTIDK LNKLDEDLKTEYAETEPNEQFIQQDFKKLQESTGKGKNATPIHYNAKAYRESDIHKKK GDIEKHSEAYLSVKKEEAKEREIKELKKKLNDGVSDPDEYLEIAKKVGYENLEPTQVQ LAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGIWDFITDPGETLSALGNAA MHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAVAVVGTKGAGAINKAD AAGKVINKASQAGKKIKDVKIPDLLPYNPKYKLALADNVPYNVVDSQNLKNELLTNAK KIPDGTRKPFTGQKKSPPWLNKEKYDAYEIEGKVKAKGKVKDVSRRVYTMKDIDINQK TEFGVTNLQLMKNGNAPYAKDGTQINLHHLIQEEPGPMLEIPNSLHTKYSDVIHQLKS DGESFRNDKVLKAQYESFRKRYWKWRAKQFENEN*" gene complement(1933075..1934877) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" promotor_-10 complement(1934901..1934920) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-10" upshifts complement(1934917) /Source="Nicolas_upshifts" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" promotor_-35 complement(1934932..1934939) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-35" CDS complement(1934979..1935536) /gene="yobM" /locus_tag="BSU_19010" /old_locus_tag="BSU19010" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="NP_389782.3" /db_xref="EnsemblGenomes-Gn:BSU19010" /db_xref="EnsemblGenomes-Tr:CAB13793" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG13505" /db_xref="UniProtKB/Swiss-Prot:O34377" /translation="MTNFVHKTVNGLKSLLDEKGAIKLFCSEGDIMEFLVTFSQDKAT LNDIQSFEAKHQLTLPQDYQKFMTLHNGAKIFEILSDGENIGGGLQLFSLEEIEEELK YEDLFEDINGIPIGYLLEECHLMIDKDKVNQGDPNYLYIFESGLEYNPLNLNFEKFLD RYILANGEPFWDWRYYTAENYYRTR*" gene complement(1934979..1935536) /gene="yobM" /locus_tag="BSU_19010" /old_locus_tag="BSU19010" S_feature complement(1935543..1935938) /Source="Nicolas_S_feature" /locus_tag="new_2074222_2074617_c" /HighExp="M0t90, LoTm, M40t90, Lbstat, LBGstat, M9-stat, T0.30H, T2.30H, T1.0H, T2.0H" /AntisenseName="yobN" /AntisenseCor="-6.3634699133798794E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S722" promotor_-35 1935601..1935606 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-35" promotor_-10 1935622..1935640 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-10" upshifts 1935631 /Source="Nicolas_upshifts" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" S_feature 1935633..1935759 /Source="Nicolas_S_feature" /locus_tag="new_2074312_2074438" /HighExp="S3, S4, S5, S6, M9-stat, S8, S7, T5.0H, T4.0H, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S723" CDS 1935664..1937100 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /EC_number="1.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amine oxidase (flavoprotein)" /protein_id="NP_389783.2" /db_xref="EnsemblGenomes-Gn:BSU19020" /db_xref="EnsemblGenomes-Tr:CAB13794" /db_xref="GOA:O34363" /db_xref="InterPro:IPR001613" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13506" /db_xref="UniProtKB/Swiss-Prot:O34363" /translation="MNSLMNDDMVKIIRNGLSASQHPKHILVIGAGLSGLVSASLLKN AGHRVTILEASGRAGGRVCTLRSPFSDDLYFNAGPMRIPNNHSLTLEYIKKFKLPTNV FINRTPMDIIYANGIKTRLQVFERAPGILRYPVAPNEQGKTSEELMLSLLQPILNFIN QNPARNWRIVEEQYKNHSLSSFLNTYFSYGAIDMIGVLLDMEAYMGMSLVEVLRESIF FSSPAHFYEITGGMDLLPHAFLPQLKTNILYHQKMMKMSQGENRVTIHCQHQQTAEFT SFTADLAIVTIPFSTLRFVKVEPYHSFSYYKRRAIRELNYISATKIGIEFKSRFWEKA GQHGGKSITDLPIRFSYYPSRNIGANGHAVILASYTWADEALIWDSLSEGERIQYTLL NLSEIYGDIVWSEFVSGTSFSWSQYPYSAGGFTAFEPGQELELYPYIPVPEGRVHFAG EHASLTHAWMQGAIESGIRVAYEVNRLP*" gene 1935664..1937100 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" promotor_-10 complement(1935924..1935943) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1935938) /Source="Nicolas_upshifts" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" promotor_-35 complement(1935957..1935963) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1937101..1937432 /Source="Nicolas_S_feature" /locus_tag="new_2075780_2076111" /HighExp="S3, S8, S4, S5, S7, M9-stat, S6, T5.0H, C30, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S724" promotor_-35 1937414..1937422 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1937433..1937451 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1937434..1937526 /Source="Nicolas_S_feature" /locus_tag="new_2076113_2076205" /HighExp="M9-stat, T1.30H, T2.0H, S2, T2.30H, Lbstat, BC, T0.30H, T3.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S725" upshifts 1937434 /Source="Nicolas_upshifts" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" CDS 1937527..1939947 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11562162, 19450535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage-related pre-neck appendage protein; defective prophage 6" /protein_id="NP_389784.1" /db_xref="EnsemblGenomes-Gn:BSU19030" /db_xref="EnsemblGenomes-Tr:CAB13795" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR021865" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG13507" /db_xref="UniProtKB/Swiss-Prot:O34433" /translation="MVHFKNCPDPSLNANSQSHPEFSSELEHIKTRMQNFIKHSVTDQ NIEVTDARVTAEGEVTSLLKERLDKEYYRLLSKITREVNVADFGAVPDGRDNTEAFRK AIGNGRVKVHVPAGEYLVQGIKLPSWTTIVGQGKGITVIKLHEDTPAHEWVITNDDYQ NGNRNIFVQGMSLDWNPSRQCGVRNPGGQFSSCLTFAKVEYGWIKDVEAINAGLHGID ITSPTYDHLPDTDWTKDGSRYIWIDNCVTYGSGDDGITTHYSEYIFISNCHSGNPRGT EFAEGVSNSNGIEIDDGSRHVWLLNNFTSGNIRGVEVKAHELWPASQNVHIIGHISYR DVRAFDLRHIGHHQITDPESTTAYDVTLIDCSAVEPVFNSLYDAVTPRALVISAYKNV NVSGFTAIGDPDYDYKENPVVALQYRSQNITINGIKIRGFKKAGVDINLSGGSNKTDY IKISNFDIYKSAPKGISIGGGLYNVNILNGTMITDNGTVAIQSPNNQATILGVQSEGY SVAASIKGQTYQQVPINLKGGIQLATTSGFAVNQTSAVIAGTGDITARGERNAVISSS GGSSTEGSRALIASSNNAHIRGNQASRTILSSENIILEEPYTVAGGHQSIKWLLDSVR GNGTFAGAISSSLGGYGEYFESSTGQLIHTGTIVTLRGEKIVPANVGDYMLGVISETS AFISGASSFVWQGRYLTNEFGGFIYETVTDEESGELIRVPKQNPDYDTALEANYHSRA ARDEWHVVGLVGQHYVRIDETVNQGDYLTAHNGIGTKATEGSWKVMKITSAYTSEKGY GIALTVIK*" gene 1937527..1939947 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" S_feature complement(1939869..1940504) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" S_feature 1939948..1940405 /Source="Nicolas_S_feature" /locus_tag="new_2078627_2079084" /HighExp="M9-stat, Lbstat, BC, T1.30H, S2, T0.30H, T2.0H, T3.0H, T2.30H, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S727" promotor_-35 1940380..1940387 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1940399..1940418 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1940407..1940517 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" upshifts 1940407 /Source="Nicolas_upshifts" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" misc_RNA 1940417..1940524 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" gene 1940417..1940524 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" downshifts 1940502 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" CDS complement(1940535..1940867) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" gene complement(1940535..1940867) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" downshifts complement(1940549) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" CDS complement(1940932..1941657) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" gene complement(1940932..1941657) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" CDS complement(1941672..1942415) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" gene complement(1941672..1942415) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" promotor_-10 complement(1942443..1942462) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1942462) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" promotor_-35 complement(1942476..1942482) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1942493..1943068) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" gene complement(1942493..1943068) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" CDS complement(1943074..1943775) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" gene complement(1943074..1943775) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" promotor_-10 complement(1943805..1943824) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1943805) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" promotor_-10 complement(1943809..1943824) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1943839..1943846) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1943839..1943846) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1943849) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" CDS complement(1943852..1944334) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" gene complement(1943852..1944334) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" misc_feature complement(1944373..1944390) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1944377) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" CDS complement(1944388..1945329) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" gene complement(1944388..1945329) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" downshifts complement(1944421) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(1945359..1945378) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1945367) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" promotor_-35 complement(1945392..1945396) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1945400..1945409 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1945422..1945441 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1945430 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" S_feature 1945445..1945509 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1945481..1945486 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1945502..1945520 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1945511 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" CDS 1945535..1946080 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" gene 1945535..1946080 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" downshifts 1946039 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" CDS complement(1946107..1946430) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" gene complement(1946107..1946430) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" downshifts complement(1946114) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" promotor_-10 complement(1946451..1946470) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1946462) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" promotor_-35 complement(1946483..1946490) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1946551..1946557 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1946568 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" promotor_-10 1946572..1946591 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1946624..1947301 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" gene 1946624..1947301 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" downshifts 1947293 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" CDS complement(1947391..1947927) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" gene complement(1947391..1947927) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" downshifts complement(1947414) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1947954..1947973) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1947974) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" promotor_-35 complement(1947987..1947994) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1948064..1948846) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" gene complement(1948064..1948846) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" downshifts complement(1948073) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" promotor_-10 complement(1948868..1948886) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948887) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" promotor_-35 complement(1948900..1948906) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1948943..1948950 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1948965..1948984 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1948969 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" CDS 1949017..1949514 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" gene 1949017..1949514 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" promotor_-35 1949521..1949524 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1949540..1949559 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1949542 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" CDS 1949578..1950555 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" gene 1949578..1950555 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" downshifts 1950527 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" promotor_-35 1950652..1950659 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1950674..1950693 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1950681 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" CDS 1950717..1951775 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" gene 1950717..1951775 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" S_feature 1951776..1951845 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1951829..1951835 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1951847..1951866 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1951847 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" CDS 1951895..1953007 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" gene 1951895..1953007 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" CDS 1953026..1953625 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" gene 1953026..1953625 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" downshifts 1953563 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" downshifts 1953607 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" S_feature complement(1953647..1954145) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1953683) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" promotor_-35 1954117..1954126 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1954129..1954147) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1954138..1954332 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1954138 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" promotor_-10 1954139..1954158 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1954145) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" promotor_-35 complement(1954164..1954169) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1954220..1955083) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" gene complement(1954220..1955083) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" downshifts complement(1954233) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" downshifts 1954289 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" downshifts complement(1954321) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" S_feature 1954334..1955101 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1955079..1955083 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1955092..1955106 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1955103 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1955122..1955141) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1955135) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" S_feature complement(1955137..1955330) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1955153..1955159) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1955331..1957106) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" gene complement(1955331..1957106) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" S_feature complement(1957107..1957237) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1957230..1957432) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" gene complement(1957230..1957432) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" downshifts complement(1957282) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" promotor_-10 complement(1957430..1957449) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1957448) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" S_feature complement(1957450..1957642) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1957462..1957469) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1957671..1958297) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" gene complement(1957671..1958297) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" downshifts complement(1957687) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" promotor_-10 complement(1958331..1958350) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1958344) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" promotor_-35 complement(1958364..1958371) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1958447..1958938) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" gene complement(1958447..1958938) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" downshifts complement(1958456) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1958950..1958968) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1958962) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" promotor_-35 complement(1958982..1958988) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1959013..1959345) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" gene complement(1959013..1959345) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" S_feature complement(1959346..1959636) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1959361..1959366 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1959381..1959399 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1959383 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" CDS 1959423..1959650 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" gene 1959423..1959650 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" CDS complement(1959637..1960113) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" gene complement(1959637..1960113) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" S_feature 1959651..1960158 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1960114..1960216) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1960131..1960136 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1960151..1960169 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1960160 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" CDS 1960180..1960443 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" gene 1960180..1960443 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" promotor_-10 complement(1960196..1960215) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960216) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" S_feature complement(1960218..1960743) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1960229..1960233) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1960448..1960681 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" gene 1960448..1960681 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" downshifts 1960668 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" CDS complement(1960767..1961111) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" gene complement(1960767..1961111) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" downshifts complement(1960788) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" S_feature complement(1961112..1961184) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1961180..1961199) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961184) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" S_feature complement(1961186..1961289) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1961213..1961218) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1961276..1961291) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961289) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" promotor_-35 complement(1961304..1961313) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1961432) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" CDS complement(1961468..1961671) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" gene complement(1961468..1961671) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" promotor_-10 complement(1961692..1961711) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961710) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" S_feature complement(1961712..1961778) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1961727..1961734) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1961744..1961751 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1961763 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" misc_feature complement(1961765..1961777) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1961765..1961784 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1961768..1961900 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1961789) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" CDS 1961901..1963388 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" gene 1961901..1963388 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" promotor_-10 complement(1962344..1962361) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1962350) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1962374..1962382) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1963374 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" promotor_-35 1963436..1963441 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1963457..1963475 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1963462 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" CDS 1963489..1965387 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" gene 1963489..1965387 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" promotor_-10 complement(1964432..1964451) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1964440) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1964465..1964474) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1965377..1966222 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" gene 1965377..1966222 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" S_feature 1966223..1967729 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1966255..1967592) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" gene complement(1966255..1967592) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" downshifts complement(1966266) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" promotor_-10 complement(1967620..1967639) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1967635) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" S_feature complement(1967637..1968795) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1967654..1967661) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1967713..1967716 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1967731..1967750 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1967731 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" CDS 1967811..1968776 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" gene 1967811..1968776 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" downshifts 1968764 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" CDS complement(1968826..1970079) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" gene complement(1968826..1970079) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" downshifts complement(1968840) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" CDS complement(1970095..1972929) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" gene complement(1970095..1972929) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" promotor_-10 complement(1973024..1973043) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1973039) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" S_feature complement(1973041..1973157) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1973058..1973065) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1973158..1975074) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" gene complement(1973158..1975074) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" CDS complement(1975085..1975999) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" gene complement(1975085..1975999) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" promotor_-10 complement(1976003..1976022) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1976018) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" promotor_-35 complement(1976039..1976043) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1976063..1976653) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" gene complement(1976063..1976653) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" CDS complement(1976746..1977990) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" gene complement(1976746..1977990) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" downshifts complement(1976748) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" promotor_-10 complement(1978053..1978071) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1978066) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" S_feature complement(1978068..1978288) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1978084..1978091) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1978274..1978292) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1978288) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" promotor_-35 complement(1978304..1978312) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1978372..1979589) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" gene complement(1978372..1979589) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" downshifts complement(1978398) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1979622..1979641) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1979630) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" promotor_-35 complement(1979655..1979662) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1979825..1980448) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" gene complement(1979825..1980448) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" S_feature complement(1980449..1980599) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1980475..1980481 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1980487 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" promotor_-10 1980495..1980506 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1980513..1980521 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1980529..1980629 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1980533..1980551 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1980544 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1980582..1980600) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1980589..1980674 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1980589 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" upshifts complement(1980599) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" promotor_-35 complement(1980616..1980622) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1980650..1980657 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1980670..1980689 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1980676 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" CDS 1980714..1982072 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" gene 1980714..1982072 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" promotor_-10 complement(1981056..1981067) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1981061) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1981081..1981087) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1982088..1982936 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" gene 1982088..1982936 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" promotor_-10 complement(1982352..1982371) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1982359) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1982385..1982393) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1982899 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" downshifts complement(1982931) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" CDS complement(1982962..1983627) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" gene complement(1982962..1983627) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" downshifts complement(1982976) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" CDS complement(1983646..1983996) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" gene complement(1983646..1983996) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" CDS complement(1983993..1984271) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" gene complement(1983993..1984271) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" promotor_-10 complement(1984298..1984317) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1984314) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" promotor_-35 complement(1984332..1984338) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1984347..1985243) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" gene complement(1984347..1985243) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" promotor_-35 1985085..1985094 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1985105 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" promotor_-10 1985108..1985127 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1985123..1985341 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1985267..1985286) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1985287) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" promotor_-35 complement(1985298..1985305) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1985342..1985815 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" gene 1985342..1985815 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" downshifts 1985812 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" CDS complement(1985850..1986086) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" gene complement(1985850..1986086) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" downshifts complement(1985858) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(1986109..1986128) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1986124) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" promotor_-35 complement(1986142..1986151) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1986171..1987505) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" gene complement(1986171..1987505) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" S_feature complement(1987506..1987641) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1987638..1987657) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1987648) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" promotor_-35 complement(1987672..1987679) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1987737..1987744 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1987759..1987778 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1987762 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" S_feature 1987763..1987869 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1987870..1988259 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" gene 1987870..1988259 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" downshifts 1988269 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" CDS complement(1988666..1989004) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" gene complement(1988666..1989004) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" promotor_-35 1989027..1989034 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1989048..1989067 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1989057 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" S_feature 1989061..1989133 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1989092..1989111) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1989095) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" promotor_-35 complement(1989123..1989129) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1989134..1989742 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" gene 1989134..1989742 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" downshifts 1989732 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" CDS complement(1989785..1990387) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" gene complement(1989785..1990387) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" CDS complement(1990403..1991314) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" gene complement(1990403..1991314) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" promotor_-10 complement(1991343..1991362) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1991359) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" promotor_-35 complement(1991378..1991383) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1991435..1991438 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1991453..1991472 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1991455 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" CDS 1991498..1991698 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" gene 1991498..1991698 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" CDS 1991698..1993188 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" gene 1991698..1993188 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" promotor_-10 complement(1992433..1992444) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1992437) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1992458..1992464) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1993176 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" CDS complement(1993223..1994623) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" gene complement(1993223..1994623) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" downshifts complement(1993247) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" promotor_-35 1994394..1994403 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1994415..1994430 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1994429 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1994643..1994662) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1994663) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" promotor_-35 complement(1994676..1994683) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1994722..1994731 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1994737 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" promotor_-10 1994744..1994763 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1994776..1995477 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" gene 1994776..1995477 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" promotor_-35 1995502..1995510 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1995524..1995543 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1995529 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" CDS 1995565..1995816 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" gene 1995565..1995816 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" downshifts 1995837 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" CDS complement(1995887..1996708) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" gene complement(1995887..1996708) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" downshifts complement(1995913) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" S_feature complement(1996709..1996790) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1996791..1997492) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" gene complement(1996791..1997492) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" S_feature complement(1997493..1997582) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1997567..1997586) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1997582) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" promotor_-35 complement(1997602..1997606) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1997640..1997646 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1997661..1997672 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1997678 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" CDS 1997694..1997819 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" gene 1997694..1997819 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" downshifts 1997817 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" CDS complement(1997859..1998173) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" gene complement(1997859..1998173) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" downshifts complement(1997871) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1998194..1998212) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1998201) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" promotor_-35 complement(1998223..1998231) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1998234..1998845) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" gene complement(1998234..1998845) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" CDS complement(1998923..1999099) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" gene complement(1998923..1999099) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" downshifts complement(1998927) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" upshifts complement(1998938) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" promotor_-10 complement(1998942..1998961) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1998977..1998980) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1999113..1999131) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1999134) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" S_feature complement(1999136..1999357) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1999147..1999152) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1999157..1999162 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1999177..1999195 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1999179 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" CDS 1999218..1999361 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" gene 1999218..1999361 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" CDS complement(1999358..2000038) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" gene complement(1999358..2000038) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" S_feature 1999362..2000373 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(2000065..2000084) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2000071) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" promotor_-35 complement(2000098..2000107) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2000189..2000413) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" gene complement(2000189..2000413) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" downshifts complement(2000203) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2000454..2000473) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2000466) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" CDS complement(2000500..2000778) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" gene complement(2000500..2000778) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" CDS complement(2000775..2002190) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" gene complement(2000775..2002190) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" promotor_-35 2001446..2001449 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2001465..2001484 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2001470 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2002219..2003046) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " gene complement(2002219..2003046) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" CDS complement(2003024..2004334) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" gene complement(2003024..2004334) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" CDS complement(2004343..2004996) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " gene complement(2004343..2004996) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" CDS complement(2004981..2005670) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" gene complement(2004981..2005670) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" CDS complement(2005677..2007011) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" gene complement(2005677..2007011) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" CDS complement(2006992..2007147) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" gene complement(2006992..2007147) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" promotor_-10 complement(2007030..2007048) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2007046) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" promotor_-35 complement(2007064..2007069) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2007141..2007374) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" gene complement(2007141..2007374) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" downshifts complement(2007148) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" promotor_-35 2007250..2007254 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2007263..2007277 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2007278 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2007279..2007298) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2007288) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2007313..2007322) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2007334..2008113) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" gene complement(2007334..2008113) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" CDS complement(2008142..2009422) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" gene complement(2008142..2009422) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" promotor_-10 complement(2008790..2008808) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2008806) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2008822..2008829) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2009390..2009408) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2009400) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2009424..2009429) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2009487..2009792) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " gene complement(2009487..2009792) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" downshifts complement(2009620) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" promotor_-10 complement(2009816..2009835) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(2009831) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" promotor_-35 complement(2009849..2009858) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 2009928..2009937 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2009951..2009970 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2009951 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" upshifts complement(2009972) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2009974..2009988) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2009997..2010001) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2009997..2010398 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" gene 2009997..2010398 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" CDS 2010405..2011358 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" gene 2010405..2011358 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" downshifts 2011348 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" CDS complement(2011429..2012577) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" gene complement(2011429..2012577) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" downshifts complement(2011446) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" promotor_-35 2012590..2012594 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2012603..2012622) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2012610..2012629 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2012612) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 2012620 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2012881..2012889 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2012903..2012922 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2012906 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" CDS 2012947..2013972 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 2012947..2013972 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 2013350 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" SCAR 2013366..2013367 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 2013964 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" CDS complement(2014016..2014447) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" gene complement(2014016..2014447) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" downshifts complement(2014021) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" CDS complement(2014448..2014981) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" gene complement(2014448..2014981) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" promotor_-35 2014985..2014991 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2015002..2015112 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 2015002 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" promotor_-10 2015004..2015023 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2015009..2015028) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2015029) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" promotor_-35 complement(2015044..2015045) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2015113..2015538 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" gene 2015113..2015538 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" downshifts 2015526 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" S_feature 2015571..2016802 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(2015588..2016925) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" gene complement(2015588..2016925) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" CDS complement(2016997..2017191) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" gene complement(2016997..2017191) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" downshifts complement(2017010) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" CDS complement(2017204..2017767) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" gene complement(2017204..2017767) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" CDS complement(2017777..2018544) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" gene complement(2017777..2018544) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" promotor_-10 complement(2018568..2018587) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018585) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" promotor_-35 complement(2018598..2018605) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018622..2019203) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" gene complement(2018622..2019203) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" S_feature complement(2019204..2019319) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(2019351..2019602) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" gene complement(2019351..2019602) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" downshifts complement(2019364) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2019625..2019644) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2019639) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" CDS complement(2019688..2020956) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" gene complement(2019688..2020956) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" promotor_-10 complement(2020990..2021009) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021009) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" promotor_-35 complement(2021021..2021028) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2021163..2021182 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2021166 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" CDS 2021205..2022200 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" gene 2021205..2022200 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" CDS 2022221..2022862 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" gene 2022221..2022862 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" S_feature 2022863..2023964 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(2022901..2023521) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" gene complement(2022901..2023521) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" downshifts complement(2022927) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" CDS complement(2023522..2024028) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" gene complement(2023522..2024028) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" CDS complement(2024025..2024819) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" gene complement(2024025..2024819) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" CDS complement(2024903..2025436) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" gene complement(2024903..2025436) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" downshifts complement(2024908) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" promotor_-35 2025366..2025371 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2025382..2026328 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 2025384 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" promotor_-10 2025388..2025406 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2025454..2026065) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" gene complement(2025454..2026065) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" promotor_-10 complement(2026097..2026116) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2026116) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" promotor_-35 complement(2026129..2026134) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2026285 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" CDS complement(2026325..2027098) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" gene complement(2026325..2027098) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" downshifts complement(2026360) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" CDS complement(2027140..2027574) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" gene complement(2027140..2027574) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" downshifts complement(2027152) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" promotor_-10 complement(2027603..2027622) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(2027614) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" S_feature complement(2027616..2027680) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(2027636..2027643) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(2027659) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" CDS complement(2027681..2029357) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" gene complement(2027681..2029357) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" S_feature complement(2029358..2029548) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(2029537..2029556) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2029548) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" promotor_-35 complement(2029571..2029574) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2029646..2030779) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" gene complement(2029646..2030779) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" downshifts complement(2029662) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" misc_feature complement(2030801..2030820) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2030804) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" CDS complement(2030839..2031456) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" gene complement(2030839..2031456) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" CDS complement(2031472..2031954) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" gene complement(2031472..2031954) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" S_feature complement(2031955..2032102) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(2032093..2032111) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(2032103) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" promotor_-35 complement(2032122..2032130) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 2032156..2032165 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2032178..2032193 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 2032180..2032266 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 2032180 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" promotor_-35 2032229..2032236 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2032251..2032270 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 2032268 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" CDS 2032297..2033202 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" gene 2032297..2033202 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" misc_feature 2033237..2033256 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2033251 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" S_feature 2033252..2033432 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 2033433..2034581 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" gene 2033433..2034581 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" S_feature complement(2033602..2034631) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 2034577 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2034613..2034632) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2034631) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" promotor_-35 complement(2034647..2034655) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2034662..2034808 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" gene 2034662..2034808 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" promotor_-35 2034701..2034708 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2034722..2034741 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2034733..2034823 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 2034733 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" CDS 2034824..2035024 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" gene 2034824..2035024 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" downshifts 2035039 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" CDS complement(2035076..2035258) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" gene complement(2035076..2035258) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" S_feature 2035084..2035389 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(2035093) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2035319..2035337) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2035351..2035357) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2035355) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" promotor_-35 2035365..2035371 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2035386..2035397 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2035391 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" CDS 2035414..2035683 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" gene 2035414..2035683 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" downshifts 2035538 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" downshifts 2035666 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" CDS complement(2035711..2035893) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" gene complement(2035711..2035893) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" downshifts complement(2035731) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" CDS complement(2035886..2036566) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" gene complement(2035886..2036566) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" S_feature complement(2036567..2036704) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 2036583..2036588 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2036601..2036620 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2036606 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" CDS 2036649..2037338 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" gene 2036649..2037338 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" promotor_-10 complement(2036699) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2036702..2036718) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2036705) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" S_feature complement(2036706..2037095) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(2037076..2037095) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2037093) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" promotor_-35 complement(2037107..2037115) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2037338..2037736 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" gene 2037338..2037736 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" promotor_-35 2037729..2037735 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2037750..2037761 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2037761 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" CDS 2037778..2037906 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" gene 2037778..2037906 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" S_feature 2037907..2038887 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(2037914..2038804) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" gene complement(2037914..2038804) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" downshifts complement(2037951) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" promotor_-10 complement(2038826..2038845) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2038833) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" promotor_-35 complement(2038857..2038863) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2038861 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" CDS complement(2038905..2039051) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" gene complement(2038905..2039051) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" downshifts complement(2038921) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" upshifts complement(2039075) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" promotor_-10 complement(2039076..2039087) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2039102..2039108) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2039126..2039383) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" gene complement(2039126..2039383) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" promotor_-10 complement(2039403..2039422) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2039418) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" promotor_-35 complement(2039434..2039441) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2039448..2043029) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" gene complement(2039448..2043029) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" S_feature complement(2043030..2043101) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(2043091..2043110) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2043101) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" S_feature complement(2043146..2043343) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(2043189) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" CDS complement(2043205..2043294) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" gene complement(2043205..2043294) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" promotor_-10 complement(2043322..2043341) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2043343) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" promotor_-35 complement(2043356..2043363) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2043365..2043871) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" gene complement(2043365..2043871) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" CDS complement(2043875..2044972) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" gene complement(2043875..2044972) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" promotor_-10 complement(2044990..2045001) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2044993) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" promotor_-35 complement(2045016..2045022) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2045046..2046362) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" gene complement(2045046..2046362) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" downshifts complement(2045059) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" CDS complement(2046359..2046943) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" gene complement(2046359..2046943) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" misc_RNA complement(2047032..2047132) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" gene complement(2047032..2047132) /gene="gswA" /locus_tag="BSU_misc_RNA_34" downshifts complement(2047039) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" S_feature complement(2047133..2047273) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(2047274..2048779) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" gene complement(2047274..2048779) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" promotor_no_box complement(2048715..2048815) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2048755) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" downshifts 2048767 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" promotor_-10 complement(2048805..2048824) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048821) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" promotor_-35 complement(2048838..2048845) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2048891..2049883) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" gene complement(2048891..2049883) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" downshifts complement(2048909) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" CDS complement(2049928..2050518) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" gene complement(2049928..2050518) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" CDS complement(2050520..2051494) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" gene complement(2050520..2051494) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" CDS complement(2051532..2052551) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" gene complement(2051532..2052551) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" promotor_-10 complement(2052599..2052618) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2052609) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" promotor_-35 complement(2052630..2052637) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2052672..2052679 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2052693..2052772 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 2052693 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" promotor_-10 2052694..2052713 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2052773..2053600 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " gene 2052773..2053600 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" CDS 2053602..2054366 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" gene 2053602..2054366 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" downshifts 2054355 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" downshifts complement(2054397) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" CDS complement(2054407..2056332) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" gene complement(2054407..2056332) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" promotor_-10 complement(2056363..2056382) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2056367) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" S_feature complement(2056369..2056433) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(2056397..2056401) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2056434..2056625) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" gene complement(2056434..2056625) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" promotor_-10 complement(2056644..2056662) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2056653) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" S_feature complement(2056655..2056960) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(2056678..2056683) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2056692..2056698 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2056713..2056724 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2056722 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" CDS 2056789..2056941 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" gene 2056789..2056941 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" downshifts 2056951 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" CDS complement(2056994..2058151) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" gene complement(2056994..2058151) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" downshifts complement(2057005) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2058239..2058639) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2058239..2058639) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" downshifts complement(2058249) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" promotor_-10 complement(2058636..2058655) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2058654) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" promotor_-35 complement(2058670..2058676) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2058698..2058994) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" gene complement(2058698..2058994) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" promotor_-10 complement(2059019..2059038) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2059029) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" promotor_-35 complement(2059052..2059059) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2059072..2059701) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" gene complement(2059072..2059701) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" downshifts complement(2059667) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" CDS complement(2059703..2059930) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" gene complement(2059703..2059930) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" promotor_-10 complement(2059958..2059977) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(2059973) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" S_feature complement(2059975..2060129) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(2059991..2059999) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(2060014..2060142) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" gene complement(2060014..2060142) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" upshifts complement(2060129) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" S_feature complement(2060131..2060242) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(2060132..2060151) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(2060167..2060171) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2060243..2061484) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" gene complement(2060243..2061484) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" promotor_-10 complement(2061198..2061216) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(2061207) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" promotor_-35 complement(2061231..2061238) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(2061500..2063749) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" gene complement(2061500..2063749) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" promotor_-10 complement(2063765..2063784) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2063781) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" promotor_-35 complement(2063798..2063804) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2063852..2064358) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" gene complement(2063852..2064358) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" downshifts complement(2063875) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" promotor_-10 complement(2064402..2064421) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2064419) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" promotor_-35 complement(2064435..2064442) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 2064440..2064449 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2064463..2064482 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2064475 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" CDS 2064496..2064915 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" gene 2064496..2064915 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" S_feature 2064916..2065066 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(2064936..2065313) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" gene complement(2064936..2065313) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" downshifts complement(2064969) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" S_feature 2065311..2065456 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(2065343..2065361) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2065362) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" promotor_-35 complement(2065375..2065384) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2065457..2065476 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2065458 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" CDS 2065501..2065689 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" gene 2065501..2065689 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" downshifts 2065705 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" CDS complement(2065728..2066099) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" gene complement(2065728..2066099) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" downshifts complement(2065761) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2066111..2066130) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066124) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" promotor_-35 complement(2066143..2066148) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2066145..2066390) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" gene complement(2066145..2066390) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" promotor_-10 complement(2066416..2066434) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066421) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" promotor_-35 complement(2066446..2066454) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2066540..2066546 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2066561..2066572 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2066568 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" CDS 2066589..2066693 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" gene 2066589..2066693 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" downshifts 2066675 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" CDS complement(2066718..2067680) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" gene complement(2066718..2067680) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" promotor_-35 2066848..2066857 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2066869..2066884 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2066869 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" S_feature 2066873..2067208 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 2067179..2067183 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2067199..2067218 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2067210..2067720 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 2067210 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" S_feature complement(2067681..2068137) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 2067721..2068341 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" gene 2067721..2068341 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" promotor_-10 complement(2068126..2068137) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2068137) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" promotor_-35 complement(2068152..2068158) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2068363..2071107 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" gene 2068363..2071107 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" downshifts complement(2070777) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" downshifts 2071093 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" CDS complement(2071183..2071677) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" gene complement(2071183..2071677) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" downshifts complement(2071196) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" CDS complement(2071674..2072333) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" gene complement(2071674..2072333) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" CDS complement(2072352..2073050) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" gene complement(2072352..2073050) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" S_feature complement(2073051..2073142) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(2073143..2074435) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" gene complement(2073143..2074435) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" S_feature complement(2074436..2074497) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(2074497..2074516) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2074497) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2074531..2074538) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2074579..2075760) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" gene complement(2074579..2075760) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" downshifts complement(2074583) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" CDS complement(2075783..2076268) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" gene complement(2075783..2076268) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" promotor_-10 complement(2076216..2076235) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2076233) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2076248..2076255) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2076277..2076447) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" gene complement(2076277..2076447) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" S_feature complement(2076448..2076519) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 2076481..2076487 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2076502..2076521) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2076502..2076513 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2076509..2076583 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 2076509 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2076519) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" S_feature complement(2076521..2076589) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(2076537..2076543) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2076553 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" CDS complement(2076590..2079385) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" gene complement(2076590..2079385) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" promotor_-35 2077058..2077062 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2077059 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2077064..2077068 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2077715..2077730) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2077729) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" promotor_-35 complement(2077743..2077752) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(2079386..2079510) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(2079511..2079894) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" gene complement(2079511..2079894) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" CDS complement(2079896..2080756) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" gene complement(2079896..2080756) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" CDS complement(2080758..2081591) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" gene complement(2080758..2081591) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" S_feature complement(2081592..2081799) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(2081794..2081813) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2081799) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2081830..2081834) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2081837..2082814) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" gene complement(2081837..2082814) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" CDS complement(2082799..2083992) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" gene complement(2082799..2083992) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" CDS complement(2083997..2085130) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" gene complement(2083997..2085130) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" CDS complement(2085127..2085837) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" gene complement(2085127..2085837) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" CDS complement(2085830..2086243) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" gene complement(2085830..2086243) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" CDS complement(2086259..2087062) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" gene complement(2086259..2087062) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" CDS complement(2087074..2087409) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" gene complement(2087074..2087409) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" promotor_-10 complement(2087429..2087448) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2087439) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" promotor_-35 complement(2087462..2087469) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 2087478..2087485 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2087494..2087513) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2087499..2087518 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2087505 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" upshifts complement(2087513) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" CDS 2087549..2088421 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" gene 2087549..2088421 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" CDS complement(2088463..2089257) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" gene complement(2088463..2089257) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" downshifts complement(2088488) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" S_feature complement(2089258..2089325) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(2089326..2089883) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" gene complement(2089326..2089883) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" S_feature complement(2089884..2089963) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(2090008) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" CDS complement(2090030..2090797) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" gene complement(2090030..2090797) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" CDS complement(2090832..2091506) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" gene complement(2090832..2091506) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" CDS complement(2091508..2092011) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" gene complement(2091508..2092011) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" downshifts 2092020 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" promotor_-10 complement(2092075..2092094) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092075) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" promotor_-35 complement(2092109..2092116) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2092154..2092600) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" gene complement(2092154..2092600) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" downshifts 2092603 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" CDS complement(2092655..2093194) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" gene complement(2092655..2093194) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" downshifts complement(2092668) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2093227..2093245) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2093238) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" promotor_-35 complement(2093257..2093265) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(2093266..2094537) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" gene complement(2093266..2094537) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" S_feature complement(2094538..2094605) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(2094602..2094621) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2094605) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" promotor_-35 complement(2094635..2094642) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2094672..2094691) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2094678) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" S_feature complement(2094680..2094824) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(2094702..2094709) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(2094806..2094824) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2094824) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" promotor_-35 complement(2094840..2094845) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2094873..2096159) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" gene complement(2094873..2096159) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" downshifts complement(2094896) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" CDS complement(2096170..2097285) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" gene complement(2096170..2097285) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" CDS complement(2097334..2098416) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" gene complement(2097334..2098416) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" CDS complement(2098427..2099230) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" gene complement(2098427..2099230) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" promotor_-10 complement(2098915..2098934) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2098932) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" promotor_-35 complement(2098946..2098953) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2099223..2100425) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" gene complement(2099223..2100425) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" CDS complement(2100406..2101053) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" gene complement(2100406..2101053) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" downshifts complement(2100500) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" misc_feature complement(2100676..2100679) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2100676) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" downshifts complement(2100896) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" CDS complement(2101058..2101807) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /EC_number="4.1.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /db_xref="GOA:P03964" /db_xref="InterPro:IPR001468" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013798" /db_xref="PSEUDO:CAB14182.3" /db_xref="SubtiList:BG11038" /db_xref="UniProtKB/Swiss-Prot:P03964" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIA EVKKASPSKGLIKEDFVPVQIAKDYEAAKADAISVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDAS TLEQILKVFTPDILGVNNRNLKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTF VNEHGARAVLIGESLMRQTSQRKAIHALFRE*" gene complement(2101058..2101807) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /pseudo misc_feature complement(2101091..2101093) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2101094) /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" CDS complement(2101800..2102816) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" gene complement(2101800..2102816) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" CDS complement(2102788..2104335) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" gene complement(2102788..2104335) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" S_feature complement(2104414..2104545) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(2104457) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2104536..2104555) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(2104545) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" CDS complement(2104551..2104934) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" gene complement(2104551..2104934) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" promotor_-35 complement(2104570..2104577) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(2104931..2106019) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" gene complement(2104931..2106019) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" promotor_-10 complement(2105060..2105075) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2105073) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" promotor_-35 complement(2105088..2105096) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2106019..2107191) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" gene complement(2106019..2107191) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" promotor_-10 complement(2107226..2107245) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2107243) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2107258..2107265) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2107266..2108036) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" gene complement(2107266..2108036) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" promotor_-10 complement(2108062..2108081) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2108079) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2108093..2108099) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(2108111..2108272) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(2108154) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" CDS complement(2108273..2108722) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" gene complement(2108273..2108722) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" promotor_-10 complement(2108765..2108784) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2108772) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" promotor_-35 complement(2108797..2108804) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2108838..2109884) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" gene complement(2108838..2109884) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" CDS complement(2109826..2110527) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" gene complement(2109826..2110527) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" CDS complement(2110534..2111289) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" gene complement(2110534..2111289) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" S_feature complement(2111290..2111375) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(2111364..2111383) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2111375) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2111394..2111401) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2111453..2111680) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" gene complement(2111453..2111680) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" downshifts complement(2111474) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" CDS complement(2111702..2112274) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" gene complement(2111702..2112274) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" promotor_-10 complement(2112303..2112322) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2112313) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" S_feature complement(2112315..2112398) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(2112335..2112341) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(2112443) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" CDS complement(2112462..2112740) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" gene complement(2112462..2112740) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" S_feature complement(2112741..2112966) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(2112948..2112967) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2112966) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2112984..2112989) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2113114..2114592) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" gene complement(2113114..2114592) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" downshifts complement(2113127) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" S_feature complement(2114593..2114754) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(2114741..2114759) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(2114766) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" CDS complement(2114773..2115507) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" gene complement(2114773..2115507) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" promotor_-35 complement(2114774..2114779) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(2114799) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" CDS complement(2115529..2115732) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" gene complement(2115529..2115732) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" promotor_-10 complement(2115768..2115787) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2115789) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" promotor_-35 complement(2115801..2115808) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2115854..2116053) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(2115897) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(2116028..2116047) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2116053) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" promotor_-35 complement(2116061..2116070) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2116070..2117107) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" gene complement(2116070..2117107) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" CDS complement(2117125..2118435) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" gene complement(2117125..2118435) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" S_feature complement(2118436..2118560) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(2118546..2118565) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2118560) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" promotor_-35 complement(2118580..2118583) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2118589..2118783) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" gene complement(2118589..2118783) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" CDS complement(2118780..2119673) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" gene complement(2118780..2119673) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" CDS complement(2119670..2120269) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" gene complement(2119670..2120269) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" promotor_-35 2120142..2120148 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2120157..2120340 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 2120159 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" promotor_-10 2120162..2120173 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2120280..2120298) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2120299) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" promotor_-35 complement(2120314..2120319) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2120347..2120478 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " gene 2120347..2120478 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" downshifts 2120466 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" CDS complement(2120521..2121570) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" gene complement(2120521..2121570) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" downshifts complement(2120541) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" downshifts complement(2121445) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" CDS complement(2121583..2122731) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" gene complement(2121583..2122731) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" misc_feature 2121912..2121915 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2121939 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2122005 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" downshifts 2122709 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" S_feature complement(2122732..2122871) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(2122870..2122889) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2122871) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" S_feature complement(2122873..2122963) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(2122904..2122911) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2122964..2123638) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" gene complement(2122964..2123638) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" S_feature complement(2123639..2123716) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(2123717..2123893) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" gene complement(2123717..2123893) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" promotor_-10 complement(2123905..2123923) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2123922) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" promotor_-35 complement(2123938..2123944) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2123938..2124591) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " gene complement(2123938..2124591) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" promotor_-10 complement(2124621..2124640) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2124634) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" promotor_-35 complement(2124656..2124660) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2124684..2126036) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" gene complement(2124684..2126036) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" downshifts complement(2124699) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" CDS complement(2126071..2126988) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" gene complement(2126071..2126988) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" downshifts complement(2126459) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" misc_feature complement(2126610..2126617) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2126613) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" promotor_-10 complement(2127026..2127037) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2127035) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" promotor_-35 complement(2127051..2127057) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2127127..2127783) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" gene complement(2127127..2127783) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" downshifts complement(2127141) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2127808..2127827) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2127823) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" CDS complement(2127903..2128877) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" gene complement(2127903..2128877) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" downshifts complement(2127911) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" promotor_-35 2128731..2128736 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2128752..2128770 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2128762..2128955 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2128762 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" downshifts 2128913 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" CDS complement(2128986..2130269) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" gene complement(2128986..2130269) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" downshifts complement(2128989) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" promotor_-35 2129027..2129033 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2129045..2129049 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2129045 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2130312..2130331) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130333) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" promotor_-35 complement(2130346..2130353) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2130425..2131009) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" gene complement(2130425..2131009) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" downshifts complement(2130427) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" S_feature complement(2131010..2131091) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2131084..2131103) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2131091) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" promotor_-35 complement(2131117..2131124) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2131168..2131947) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" gene complement(2131168..2131947) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" promotor_-10 complement(2131973..2131988) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2131984) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" promotor_-35 complement(2132000..2132009) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2132033..2132476) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" gene complement(2132033..2132476) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" downshifts complement(2132050) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" CDS complement(2132539..2133261) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" gene complement(2132539..2133261) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" downshifts complement(2132820) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" CDS complement(2133212..2133781) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" gene complement(2133212..2133781) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" promotor_-10 complement(2133530..2133548) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2133546) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" promotor_-35 complement(2133563..2133569) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2133800..2134546 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2133841..2135331) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" gene complement(2133841..2135331) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" CDS complement(2135324..2136382) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" gene complement(2135324..2136382) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" promotor_-35 2135672..2135681 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2135692..2136482 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2135692 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" promotor_-10 2135694..2135713 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2136423..2136442) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2136446) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" promotor_-35 complement(2136454..2136461) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2136460..2136466 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2136480..2136499 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2136484..2136553 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2136484 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" promotor_-35 2136533..2136540 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2136555..2136647 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2136555..2136574 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2136555 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" CDS 2136648..2136896 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" gene 2136648..2136896 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" downshifts 2136880 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" CDS complement(2136936..2137508) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" gene complement(2136936..2137508) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" downshifts complement(2136956) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2137500..2137807) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" gene complement(2137500..2137807) /gene="fswB" /locus_tag="BSU_misc_RNA_78" S_feature complement(2137509..2137613) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2137806..2137825) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2137822) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" promotor_-35 complement(2137839..2137845) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2137934..2137941 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2137952 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" promotor_-10 2137956..2137975 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2138005..2139582 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" gene 2138005..2139582 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" downshifts 2139564 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" CDS complement(2139625..2140392) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" gene complement(2139625..2140392) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" downshifts complement(2139640) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" S_feature 2139894..2140506 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2140419..2140438) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2140432) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" promotor_-35 complement(2140453..2140456) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2140466 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" CDS complement(2140504..2141610) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" gene complement(2140504..2141610) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" downshifts complement(2140521) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" CDS complement(2141546..2142130) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" gene complement(2141546..2142130) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" promotor_-35 2141924..2141929 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2141940 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2141944..2141948 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2142081..2142086 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2142098 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" promotor_-10 2142102..2142120 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2142138 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2142179..2142198) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2142183..2142290 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2142187) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" promotor_-35 complement(2142211..2142218) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2142246 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" S_feature complement(2142275..2142333) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2142306) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" CDS complement(2142334..2144103) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" gene complement(2142334..2144103) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" downshifts complement(2142390) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" CDS complement(2144100..2144822) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" gene complement(2144100..2144822) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" S_feature complement(2144823..2144902) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2144903..2146078) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " gene complement(2144903..2146078) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" CDS complement(2146098..2147726) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" gene complement(2146098..2147726) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" CDS complement(2147723..2148262) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" gene complement(2147723..2148262) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" S_feature complement(2148263..2148356) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2148357..2149091) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" gene complement(2148357..2149091) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" promotor_-10 complement(2149100..2149119) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149123) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2149134..2149138) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2149183..2149719) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" gene complement(2149183..2149719) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" promotor_-10 complement(2149188..2149207) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149192) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2149222..2149229) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2149724..2150314) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" gene complement(2149724..2150314) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" CDS complement(2150302..2151450) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" gene complement(2150302..2151450) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" promotor_-10 complement(2151472..2151490) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2151479) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2151505..2151510) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2151573..2152112) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" gene complement(2151573..2152112) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" downshifts complement(2151586) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2152121..2152138) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2152136) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" promotor_-35 complement(2152153..2152158) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2152167..2152760) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" gene complement(2152167..2152760) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" CDS complement(2152750..2153505) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" gene complement(2152750..2153505) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" promotor_-35 2153349..2153358 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2153371..2153390 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2153380 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2153551..2153570) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153566) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" promotor_-35 complement(2153584..2153591) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2153731..2153738 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2153749..2153768 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2153754 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" CDS 2153786..2154310 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" gene 2153786..2154310 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" CDS complement(2154324..2154698) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" gene complement(2154324..2154698) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" downshifts complement(2154340) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2154760..2154779) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2154772) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" promotor_-35 complement(2154791..2154798) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2154811..2155275) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" gene complement(2154811..2155275) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" promotor_-35 2155146..2155150 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2155164..2155168 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2155167 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2155308..2156504) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" gene complement(2155308..2156504) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" CDS complement(2156519..2157166) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" gene complement(2156519..2157166) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" CDS complement(2157177..2158262) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" gene complement(2157177..2158262) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" S_feature complement(2158263..2158391) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2158392..2158536) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" gene complement(2158392..2158536) /gene="fswA" /locus_tag="BSU_misc_RNA_36" promotor_-10 complement(2158553..2158572) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158563) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" promotor_-35 complement(2158587..2158594) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2158656..2159000) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" gene complement(2158656..2159000) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" downshifts complement(2158671) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2159032..2159050) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159045) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" promotor_-35 2159059..2159064 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2159065..2159071) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2159079..2160001 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2159079 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" promotor_-10 2159080..2159098 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2159086..2159101) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159089) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" S_feature complement(2159091..2159157) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2159114..2159123) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2159152..2159160) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159157) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" promotor_-35 complement(2159174..2159182) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2159235..2159789) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" gene complement(2159235..2159789) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" downshifts complement(2159245) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(2159815..2159834) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159833) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" S_feature complement(2159835..2160234) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2159846..2159852) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2160056..2160292 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" gene 2160056..2160292 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" CDS complement(2160235..2160441) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" gene complement(2160235..2160441) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" misc_feature complement(2160474..2160493) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2160496) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" CDS complement(2160550..2160804) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" gene complement(2160550..2160804) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo promotor_-35 2160684..2160693 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2160695..2161084) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" gene complement(2160695..2161084) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo S_feature 2160707..2161778 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2160707..2160726 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2160707 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" CDS complement(2161062..2161265) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" gene complement(2161062..2161265) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" CDS 2161674..2161790 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" gene 2161674..2161790 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo downshifts 2161741 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" promotor_-35 2161867..2161876 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2161889..2161908 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2161889 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" CDS 2161931..2162143 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" gene 2161931..2162143 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" downshifts 2162137 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" downshifts complement(2162279) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" CDS complement(2162279..2162710) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" gene complement(2162279..2162710) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" S_feature complement(2162711..2162797) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2162780..2162799) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2162797) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" promotor_-35 complement(2162813..2162818) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2162847..2162856 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2162866..2162963 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2162866 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" promotor_-10 2162869..2162884 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2162964..2163836 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" gene 2162964..2163836 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" downshifts 2163743 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" downshifts 2163809 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" CDS complement(2163866..2165185) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" gene complement(2163866..2165185) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" downshifts complement(2163886) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" S_feature complement(2165186..2165250) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2165246..2165265) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2165250) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" promotor_-35 complement(2165280..2165287) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2165291..2166772) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" gene complement(2165291..2166772) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" misc_feature complement(2165997..2166016) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2166001) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2166723..2167334) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" gene complement(2166723..2167334) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" CDS complement(2167342..2167692) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" gene complement(2167342..2167692) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" CDS complement(2167694..2168710) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" gene complement(2167694..2168710) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" promotor_-35 2168190..2168197 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2168211..2168230 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2168233 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2168723..2169175) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" gene complement(2168723..2169175) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" CDS complement(2169188..2169613) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" gene complement(2169188..2169613) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" CDS complement(2169603..2170223) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" gene complement(2169603..2170223) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" promotor_-10 complement(2170254..2170265) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170264) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" promotor_-35 complement(2170279..2170285) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2170348..2171115) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" gene complement(2170348..2171115) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" downshifts complement(2170378) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" CDS complement(2171127..2171567) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" gene complement(2171127..2171567) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" CDS complement(2171564..2171917) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" gene complement(2171564..2171917) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" promotor_-10 complement(2171942..2171960) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2171953) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" S_feature complement(2171955..2172012) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2171972..2171980) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2172013..2173182) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" gene complement(2172013..2173182) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" promotor_-10 complement(2173211..2173222) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2173226) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" promotor_-35 complement(2173236..2173242) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2173328) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" CDS complement(2173337..2174152) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" gene complement(2173337..2174152) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" CDS complement(2174165..2175349) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" gene complement(2174165..2175349) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" promotor_-10 complement(2175398..2175417) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2175416) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" S_feature complement(2175418..2175509) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2175433..2175440) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2175510..2176400) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" gene complement(2175510..2176400) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" CDS complement(2176408..2176635) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" gene complement(2176408..2176635) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" promotor_-10 complement(2176538..2176557) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2176549) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-35 complement(2176571..2176578) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2176628) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-10 complement(2176637..2176655) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2176665..2176683) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2176671..2176677) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2176678) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-35 complement(2176700..2176705) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2176760) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" CDS complement(2176760..2177209) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" gene complement(2176760..2177209) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" promotor_-10 complement(2177233..2177252) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2177243) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" S_feature complement(2177245..2177321) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2177268..2177272) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2177322..2177966) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" gene complement(2177322..2177966) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" promotor_-10 complement(2177997..2178015) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2178014) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" promotor_-35 complement(2178030..2178035) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2178067..2178282) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" gene complement(2178067..2178282) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" downshifts complement(2178147) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" CDS complement(2178382..2179701) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" gene complement(2178382..2179701) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" downshifts complement(2178389) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" CDS complement(2179719..2181125) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" gene complement(2179719..2181125) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" promotor_-10 complement(2181173..2181192) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2181182) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" S_feature complement(2181184..2181265) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2181207..2181214) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2181266..2182693) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" gene complement(2181266..2182693) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" CDS complement(2182738..2183727) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" gene complement(2182738..2183727) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" S_feature complement(2183728..2183807) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2183789..2183808) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2183807) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" S_feature complement(2183809..2184129) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2183823..2183830) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2183848..2183855 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2183868..2183887 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2183870 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" CDS 2183909..2184259 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" gene 2183909..2184259 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" S_feature complement(2184131..2184267) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2184174) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" CDS complement(2184268..2185431) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" gene complement(2184268..2185431) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" CDS complement(2185428..2185985) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" gene complement(2185428..2185985) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" promotor_no_box complement(2185915..2186015) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2185955) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" promotor_-35 2185999..2186004 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2186020..2186038 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2186022..2186036) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2186026 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" S_feature 2186033..2186207 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2186038..2186041) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2186041) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" CDS 2186060..2186182 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" gene 2186060..2186182 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" promotor_-35 2186183..2186190 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2186204..2186223 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2186209 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" CDS 2186245..2187165 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" gene 2186245..2187165 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" downshifts 2187154 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" CDS complement(2187197..2187421) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" gene complement(2187197..2187421) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" downshifts complement(2187254) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2187444..2187463) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2187451) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" promotor_-35 complement(2187478..2187485) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2187500..2187507 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2187522..2187541 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2187529 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" CDS 2187583..2188500 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" gene 2187583..2188500 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" downshifts 2188475 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" CDS complement(2188540..2188779) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" gene complement(2188540..2188779) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" downshifts complement(2188551) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" CDS complement(2188792..2189115) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" gene complement(2188792..2189115) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" promotor_-10 complement(2188858..2188877) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2188859) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" promotor_-35 complement(2188891..2188898) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2189112..2190143) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" gene complement(2189112..2190143) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" promotor_-10 complement(2189139..2189158) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2189146) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" promotor_-35 complement(2189169..2189176) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2190136..2190480) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" gene complement(2190136..2190480) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" CDS complement(2190490..2190960) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" gene complement(2190490..2190960) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" S_feature complement(2190961..2191037) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2190961 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" promotor_-10 complement(2191012..2191031) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2191037) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" S_feature complement(2191039..2191145) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2191046..2191053) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2191146..2191484) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" gene complement(2191146..2191484) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" CDS complement(2191481..2192719) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" gene complement(2191481..2192719) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" misc_feature 2191643..2191644 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2191654 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2191709 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2192744..2192762) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2192753) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" promotor_-35 complement(2192779..2192784) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2192824..2192827 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2192842..2192861 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2192851 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" CDS 2192885..2193091 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" gene 2192885..2193091 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" promotor_-35 2193574..2193577 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2193592..2193611 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2193608 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" CDS 2193640..2194872 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" gene 2193640..2194872 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" CDS 2194719..2195081 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" gene 2194719..2195081 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" S_feature complement(2194898..2195077) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2194931) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" CDS complement(2195078..2195464) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" gene complement(2195078..2195464) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" CDS complement(2195468..2196427) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" gene complement(2195468..2196427) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" S_feature complement(2196428..2196498) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2196499..2197845) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" gene complement(2196499..2197845) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" S_feature complement(2197846..2197920) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2197921..2198700) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" gene complement(2197921..2198700) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" CDS complement(2198706..2199665) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" gene complement(2198706..2199665) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" promotor_-10 complement(2199687..2199706) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2199706) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" promotor_-35 complement(2199721..2199728) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2199762..2199769 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2199783..2200069 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2199783 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" promotor_-10 2199785..2199804 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2199799..2200044 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" gene 2199799..2200044 /gene="pswI" /locus_tag="BSU_misc_RNA_91" CDS 2200070..2200906 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" gene 2200070..2200906 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" downshifts 2200904 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" CDS complement(2200947..2202590) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" gene complement(2200947..2202590) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" downshifts complement(2200959) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" promotor_-35 2202608..2202614 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2202621 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2202628..2202639 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2202646..2202665) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2202651) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" promotor_-35 2202697..2202704 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2202718..2202737 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2202720 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" CDS 2202762..2203778 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" gene 2202762..2203778 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" downshifts 2203765 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" promotor_-35 2203827..2203836 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2203849..2203864 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2203853 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" CDS 2203888..2204649 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" gene 2203888..2204649 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" downshifts 2204557 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" downshifts 2204645 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" S_feature complement(2204677..2204877) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2204693..2204818) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" gene complement(2204693..2204818) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo downshifts complement(2204720) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" CDS complement(2204811..2204843) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" gene complement(2204811..2204843) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo promotor_-10 complement(2204871..2204890) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2204877) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" promotor_-35 complement(2204903..2204910) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2204925..2205848) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" gene complement(2204925..2205848) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" promotor_-10 complement(2205874..2205893) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2205887) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" promotor_-35 complement(2205907..2205912) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2205986..2205993 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2206007..2206026 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2206009..2206074 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2206009 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" CDS 2206075..2207544 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" gene 2206075..2207544 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" downshifts 2207527 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" downshifts 2207595 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" CDS complement(2207669..2209078) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" gene complement(2207669..2209078) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" downshifts complement(2207686) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" downshifts complement(2207759) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" misc_feature complement(2209142..2209160) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2209144) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" CDS complement(2209188..2210432) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" gene complement(2209188..2210432) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" S_feature complement(2210433..2210707) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2210453..2210460 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2210474..2210493 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2210474 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" CDS 2210505..2210792 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" gene 2210505..2210792 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" promotor_-10 complement(2210689..2210708) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2210709) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" promotor_-35 complement(2210724..2210727) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2210823..2211650 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " gene 2210823..2211650 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" downshifts 2211467 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" downshifts 2211643 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" S_feature complement(2211655..2212575) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2211698) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2211768..2211774 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2211788..2211806 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2211797 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" CDS 2211830..2212558 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" gene 2211830..2212558 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" CDS complement(2212599..2213714) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" gene complement(2212599..2213714) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" downshifts complement(2212620) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" CDS complement(2213732..2215255) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " gene complement(2213732..2215255) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" promotor_-10 complement(2214838..2214857) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214860) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" promotor_-35 complement(2214872..2214876) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2215248..2215670) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" gene complement(2215248..2215670) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" promotor_-35 2215699..2215706 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2215720..2215739 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2215734..2215887 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2215734 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" downshifts 2215844 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" CDS complement(2215872..2216402) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" gene complement(2215872..2216402) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" S_feature 2215889..2216524 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2216419..2216430) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2216426) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" promotor_-35 complement(2216445..2216451) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2216454..2217422) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" gene complement(2216454..2217422) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" downshifts complement(2216470) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" CDS complement(2217493..2218215) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" gene complement(2217493..2218215) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" downshifts complement(2217504) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" CDS complement(2218208..2218867) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" gene complement(2218208..2218867) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" S_feature complement(2218868..2218947) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2218948..2219715) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" gene complement(2218948..2219715) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" promotor_-10 complement(2219765..2219784) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2219780) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" promotor_-35 complement(2219799..2219806) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2219983..2220420) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" gene complement(2219983..2220420) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" downshifts complement(2219992) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" promotor_-10 complement(2220444..2220463) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2220465) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" promotor_-35 complement(2220478..2220485) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2220518..2220524 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2220537 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" promotor_-10 2220539..2220557 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2220581..2221474 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" gene 2220581..2221474 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" promotor_-35 2221507..2221514 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2221530..2221549 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2221538 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" CDS 2221575..2222744 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" gene 2221575..2222744 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" downshifts 2222727 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" CDS 2222817..2223653 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" gene 2222817..2223653 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" downshifts 2223651 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" downshifts complement(2223715) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" CDS complement(2223715..2224989) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" gene complement(2223715..2224989) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" CDS complement(2225012..2225995) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" gene complement(2225012..2225995) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" CDS complement(2226009..2227001) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" gene complement(2226009..2227001) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" CDS complement(2227023..2228447) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" gene complement(2227023..2228447) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" CDS complement(2228468..2229559) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" gene complement(2228468..2229559) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" CDS complement(2229578..2230672) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" gene complement(2229578..2230672) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" CDS complement(2230684..2231583) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" gene complement(2230684..2231583) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" misc_feature complement(2231619..2231638) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2231624) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" S_feature complement(2231626..2231707) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2231708..2233786) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" gene complement(2231708..2233786) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" promotor_-10 complement(2233846..2233865) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2233863) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" promotor_-35 2233873..2233880 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2233882..2233885) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2233894..2233913 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2233901 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" CDS 2233939..2234175 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" gene 2233939..2234175 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" downshifts 2234166 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" CDS complement(2234217..2235122) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" gene complement(2234217..2235122) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" downshifts complement(2234220) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" CDS complement(2235140..2236558) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" gene complement(2235140..2236558) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" misc_feature complement(2235435..2235454) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2235452) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2236573..2237691) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" gene complement(2236573..2237691) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" CDS complement(2237725..2238864) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" gene complement(2237725..2238864) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" CDS complement(2238892..2239755) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" gene complement(2238892..2239755) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" CDS complement(2239780..2240961) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" gene complement(2239780..2240961) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" downshifts complement(2240541) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" misc_feature complement(2240648..2240654) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2240651) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_no_box complement(2240875..2240975) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2240915) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2241008..2241026) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2241026) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" promotor_-35 complement(2241042..2241047) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2241088..2241819) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" gene complement(2241088..2241819) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" downshifts complement(2241095) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2241842..2241861) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2241853) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" promotor_-35 complement(2241876..2241879) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2241898..2242518) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" gene complement(2241898..2242518) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" CDS complement(2242533..2242826) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" gene complement(2242533..2242826) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" promotor_-10 complement(2242846..2242865) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2242852) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" promotor_-35 complement(2242880..2242887) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2243082..2243089 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2243103..2243122 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2243120..2243325 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2243120 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" CDS 2243134..2243286 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" gene 2243134..2243286 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" promotor_-35 2243294..2243301 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2243316..2243335 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2243327 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" CDS 2243359..2244477 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" gene 2243359..2244477 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" downshifts 2244462 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" S_feature complement(2244504..2244674) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2244547) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2244658..2244673) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2244674) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" S_feature complement(2244676..2244804) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2244685..2244694) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2244803..2244822) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2244826) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" promotor_-35 complement(2244836..2244844) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2244936) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" CDS complement(2244942..2245745) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" gene complement(2244942..2245745) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" promotor_-10 complement(2245788..2245806) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245794) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" S_feature complement(2245796..2245948) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2245817..2245825) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2245944..2245963) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245956) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" promotor_-35 complement(2245975..2245982) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2246021..2247301) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" gene complement(2246021..2247301) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" downshifts complement(2246036) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2247362..2247373) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2247376) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" promotor_-35 complement(2247388..2247394) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2247476..2249206) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" gene complement(2247476..2249206) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" downshifts complement(2247491) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" CDS complement(2249243..2249692) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" gene complement(2249243..2249692) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" S_feature complement(2249693..2249778) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2249790..2250635) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" gene complement(2249790..2250635) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" downshifts complement(2249823) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" CDS complement(2250632..2252533) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" gene complement(2250632..2252533) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" promotor_-35 2251741..2251747 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2251762..2251773 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2251770 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2252534..2252662) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2252657..2252676) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2252662) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" promotor_-35 complement(2252691..2252697) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2252708..2253598) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" gene complement(2252708..2253598) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" CDS complement(2253588..2253842) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" gene complement(2253588..2253842) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" CDS complement(2253839..2255185) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" gene complement(2253839..2255185) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" S_feature complement(2255186..2255322) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2255323..2256174) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" gene complement(2255323..2256174) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" CDS complement(2256186..2256581) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" gene complement(2256186..2256581) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" misc_feature complement(2256624..2256643) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2256643) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" S_feature complement(2256645..2256807) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2256845..2257252) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" gene complement(2256845..2257252) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" downshifts complement(2256852) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" CDS complement(2257273..2258625) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" gene complement(2257273..2258625) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" promotor_-10 complement(2258154..2258173) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2258161) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" promotor_-35 complement(2258188..2258194) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2258637..2259116) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " gene complement(2258637..2259116) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" promotor_-10 complement(2259175..2259194) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2259186) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" promotor_-35 complement(2259208..2259215) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2259272..2259928) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" gene complement(2259272..2259928) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" downshifts complement(2259279) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" CDS complement(2259929..2260618) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" gene complement(2259929..2260618) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" CDS complement(2260611..2261231) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" gene complement(2260611..2261231) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" promotor_-10 complement(2260937..2260955) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2260955) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" promotor_-35 complement(2260971..2260976) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2261245..2262444) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" gene complement(2261245..2262444) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" CDS complement(2262463..2262864) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" gene complement(2262463..2262864) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" CDS complement(2262871..2263077) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" gene complement(2262871..2263077) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" CDS complement(2263100..2263615) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" gene complement(2263100..2263615) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" CDS complement(2263609..2264532) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" gene complement(2263609..2264532) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" S_feature complement(2264533..2264607) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2264608..2264889) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" gene complement(2264608..2264889) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" promotor_-10 complement(2264909..2264927) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2264932) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" promotor_-35 complement(2264943..2264948) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2265034..2265591) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" gene complement(2265034..2265591) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" downshifts complement(2265046) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" CDS complement(2265616..2266677) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" gene complement(2265616..2266677) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" CDS complement(2266674..2267120) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" gene complement(2266674..2267120) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" promotor_-10 complement(2267169..2267188) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267185) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" promotor_-35 complement(2267201..2267208) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2267207..2267743) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" gene complement(2267207..2267743) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" promotor_-10 complement(2267756..2267767) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2267765) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" promotor_-35 complement(2267781..2267787) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2267813..2267819 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2267832 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" promotor_-10 2267834..2267852 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2267889..2267892 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2267907..2267926 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2267918 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" CDS 2267970..2268926 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" gene 2267970..2268926 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" CDS 2268966..2269361 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" gene 2268966..2269361 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" promotor_no_box 2269244..2269344 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2269304 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2269347 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" CDS complement(2269358..2270233) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" gene complement(2269358..2270233) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" promotor_-10 complement(2270260..2270278) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2270277) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" promotor_-35 complement(2270294..2270299) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2270359..2270787) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" gene complement(2270359..2270787) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" downshifts complement(2270386) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" promotor_-10 complement(2270822..2270841) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2270830) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" promotor_-35 complement(2270857..2270861) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2270887..2271723) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" gene complement(2270887..2271723) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" promotor_-10 complement(2271747..2271766) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2271758) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" S_feature complement(2271760..2272304) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2271780..2271787) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2271804..2271809 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2271823..2271842 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2271823 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" S_feature 2271834..2271913 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2271914..2272294 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" gene 2271914..2272294 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" downshifts 2272230 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" downshifts 2272274 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" CDS complement(2272329..2273795) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" gene complement(2272329..2273795) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" downshifts complement(2272349) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" CDS complement(2273788..2275134) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" gene complement(2273788..2275134) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" CDS complement(2275164..2276252) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" gene complement(2275164..2276252) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" misc_RNA complement(2276326..2276525) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" gene complement(2276326..2276525) /gene="swgA" /locus_tag="BSU_misc_RNA_37" downshifts complement(2276376) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" S_feature complement(2276526..2276596) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2276529..2276534 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2276550..2276568 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2276554 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" S_feature 2276564..2276693 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2276582..2276601) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2276596) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" promotor_-35 complement(2276615..2276622) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2276694..2278367 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" gene 2276694..2278367 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" CDS 2278388..2279182 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" gene 2278388..2279182 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" misc_feature 2278718..2278719 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2278724 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" promotor_-35 2279206..2279209 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2279225..2279244 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2279226..2279364 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2279226 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" CDS 2279365..2279538 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" gene 2279365..2279538 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" promotor_-35 2279523..2279527 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2279540..2279559 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2279540 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" CDS 2279572..2279907 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" gene 2279572..2279907 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" downshifts 2279884 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" downshifts 2279974 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" CDS complement(2280000..2280785) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" gene complement(2280000..2280785) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" downshifts complement(2280006) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2280838..2280855) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2280842) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" CDS complement(2280849..2281421) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" gene complement(2280849..2281421) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" CDS complement(2281405..2282166) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" gene complement(2281405..2282166) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" promotor_-10 complement(2282226..2282245) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2282244) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" promotor_-35 complement(2282259..2282266) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2282388..2282394 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2282395 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" promotor_-10 2282408..2282419 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2282438..2282764 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" gene 2282438..2282764 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" S_feature complement(2282581..2282805) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2282624) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" downshifts 2282746 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" CDS complement(2282806..2282985) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" gene complement(2282806..2282985) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" promotor_-10 complement(2283004..2283022) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2283019) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" promotor_-35 complement(2283037..2283043) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2283056..2283430) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" gene complement(2283056..2283430) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" CDS complement(2283431..2283814) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" gene complement(2283431..2283814) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" CDS complement(2283840..2284187) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" gene complement(2283840..2284187) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" CDS complement(2284171..2284602) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" gene complement(2284171..2284602) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" CDS complement(2284592..2284888) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" gene complement(2284592..2284888) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" CDS complement(2284902..2285873) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" gene complement(2284902..2285873) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" CDS complement(2285926..2286996) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" gene complement(2285926..2286996) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" promotor_-10 complement(2287014..2287033) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2287030) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" promotor_-35 complement(2287047..2287054) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2287179..2287407) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2287220) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" CDS complement(2287408..2288361) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" gene complement(2287408..2288361) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" promotor_-10 complement(2288385..2288404) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288406) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" promotor_-35 complement(2288418..2288424) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2288444..2288450 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2288465..2288483 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2288483 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" CDS 2288504..2289832 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" gene 2288504..2289832 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" S_feature 2289833..2290807 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2289885..2290721) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" gene complement(2289885..2290721) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" S_feature complement(2290722..2290906) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2290808..2290878 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" gene 2290808..2290878 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" CDS complement(2290945..2291325) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" gene complement(2290945..2291325) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" downshifts complement(2290951) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" promotor_-10 complement(2291354..2291372) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2291373) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" promotor_-35 complement(2291387..2291393) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2291412..2291417 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2291433..2291451 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2291442 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" promotor_-35 2291492..2291499 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2291514 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" promotor_-10 2291515..2291534 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2291557..2291802 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" gene 2291557..2291802 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" downshifts 2291699 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" downshifts 2291788 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" S_feature 2291833..2292588 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2291842..2292477) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" gene complement(2291842..2292477) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" downshifts complement(2291867) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2292499..2292518) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2292516) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" promotor_-35 complement(2292532..2292539) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2292556..2292563 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2292578..2292597 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2292590 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" upshifts complement(2292610) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2292612..2292626) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2292634..2292638) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2292634..2292807 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" gene 2292634..2292807 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" downshifts 2292795 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" CDS complement(2292839..2293153) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" gene complement(2292839..2293153) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" S_feature 2292840..2293907 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2292853) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" CDS complement(2293156..2294217) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" gene complement(2293156..2294217) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" CDS complement(2294279..2295409) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" gene complement(2294279..2295409) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" promotor_-10 complement(2295417..2295435) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2295449) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2295451..2295456) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2295492..2297408) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" gene complement(2295492..2297408) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" downshifts complement(2295519) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" promotor_-35 2296524..2296530 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2296543..2297572 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2296543 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" promotor_-10 2296546..2296564 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2297409..2297475) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2297469..2297488) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297475) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2297503..2297510) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2297525..2298490) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" gene complement(2297525..2298490) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" CDS complement(2298501..2298716) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" gene complement(2298501..2298716) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" S_feature complement(2298717..2298825) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2298826..2300349) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " gene complement(2298826..2300349) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" promotor_-10 complement(2300367..2300386) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2300380) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2300401..2300408) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2300439..2300612) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" gene complement(2300439..2300612) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" downshifts complement(2300466) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2300628..2300639) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2300640) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" promotor_-35 complement(2300653..2300659) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2300679..2301242) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" gene complement(2300679..2301242) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" S_feature complement(2301243..2301326) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2301327..2301476) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" gene complement(2301327..2301476) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" downshifts complement(2301373) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" promotor_-10 complement(2301513..2301532) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301523) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" promotor_-35 complement(2301548..2301551) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2301560..2302639) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" gene complement(2301560..2302639) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" CDS complement(2302636..2303106) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" gene complement(2302636..2303106) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" promotor_-35 2303051..2303059 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2303073..2303081 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2303074..2303247 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2303075 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" promotor_-10 complement(2303142..2303161) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2303154) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" promotor_-35 complement(2303173..2303180) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2303219..2303223 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2303239..2303258 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2303249 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" CDS 2303286..2303639 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" gene 2303286..2303639 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" CDS 2303636..2304100 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" gene 2303636..2304100 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" downshifts 2304086 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" CDS complement(2304129..2304911) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" gene complement(2304129..2304911) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" downshifts complement(2304140) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" CDS complement(2304922..2305731) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" gene complement(2304922..2305731) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" CDS complement(2305752..2306636) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" gene complement(2305752..2306636) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" CDS complement(2306636..2307565) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" gene complement(2306636..2307565) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" CDS complement(2307634..2308536) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" gene complement(2307634..2308536) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" upshifts complement(2308591) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" promotor_-10 complement(2308599..2308615) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2308626..2308628) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2308690..2310840) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" gene complement(2308690..2310840) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" downshifts complement(2308700) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(2309434..2309452) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2309442) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2309468..2309474) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2310129..2310148) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2310146) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2310162..2310171) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2310890..2310909) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2310895) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" promotor_-35 complement(2310925..2310929) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2310954..2312246) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" gene complement(2310954..2312246) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" promotor_-10 complement(2312269..2312280) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2312280) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" promotor_-35 complement(2312294..2312300) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2312353..2312961) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" gene complement(2312353..2312961) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" downshifts complement(2312368) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2313013..2313032) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2313024) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" S_feature complement(2313026..2313094) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2313047..2313054) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2313085..2313103) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2313094) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" promotor_-35 complement(2313118..2313124) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2313140..2313622) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" gene complement(2313140..2313622) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" S_feature complement(2313623..2313915) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2313665..2313671 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2313686..2313705 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2313699 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" CDS 2313732..2314499 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" gene 2313732..2314499 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" promotor_-10 complement(2313913..2313931) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2313915) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" S_feature complement(2313917..2314853) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2313945..2313951) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2314500..2314930 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2314887 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" downshifts complement(2314898) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" CDS complement(2314915..2315343) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" gene complement(2314915..2315343) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" promotor_-35 2315339..2315343 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2315353..2315367 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2315362 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" promotor_-10 complement(2315366..2315385) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2315389) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" promotor_-35 complement(2315400..2315407) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2315558..2315563 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2315579..2315597 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2315591 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" CDS 2315620..2315919 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" gene 2315620..2315919 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" promotor_-35 2315932..2315939 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2315954..2315973 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2315965..2316041 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2315965 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" CDS 2316042..2317175 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" gene 2316042..2317175 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" downshifts 2317156 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" CDS complement(2317201..2317590) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" gene complement(2317201..2317590) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" downshifts complement(2317227) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(2317621..2317632) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2317625) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" promotor_-35 complement(2317646..2317652) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2317665..2317672 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2317683..2317702 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2317684 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" CDS 2317723..2318304 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" gene 2317723..2318304 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" downshifts 2318302 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" S_feature 2318347..2318955 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2318347..2318784) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" gene complement(2318347..2318784) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" downshifts complement(2318351) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" S_feature complement(2318785..2318879) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2318875..2318894) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2318879) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" promotor_-35 complement(2318909..2318916) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2318922..2319803) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" gene complement(2318922..2319803) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" promotor_-35 2319799..2319804 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2319820..2319838 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2319836 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" misc_feature complement(2319841..2319860) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2319847) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" S_feature complement(2319849..2320176) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2319865..2319874 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2319881 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" promotor_-10 2319887..2319906 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2319919..2320173 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" gene 2319919..2320173 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" downshifts 2320160 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" CDS complement(2320200..2321093) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" gene complement(2320200..2321093) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" S_feature 2320205..2321006 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2320221) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" CDS complement(2321103..2322419) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" gene complement(2321103..2322419) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" promotor_-10 complement(2322455..2322474) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2322466) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" promotor_-35 complement(2322490..2322494) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2322523..2322532 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2322544 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" promotor_-10 2322546..2322565 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2322588..2323331 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" gene 2322588..2323331 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" downshifts 2323313 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" promotor_-35 2323335..2323342 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2323356..2323375 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2323358..2323453 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2323358 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" CDS 2323454..2324398 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" gene 2323454..2324398 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" downshifts 2324369 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" CDS complement(2324421..2325542) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" gene complement(2324421..2325542) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" downshifts complement(2324446) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" CDS complement(2325535..2326185) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" gene complement(2325535..2326185) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" S_feature complement(2326186..2326294) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2326282..2326301) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326294) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2326296..2326409) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2326317..2326321) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2326442..2326804) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" gene complement(2326442..2326804) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" downshifts complement(2326454) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" promotor_-35 2326800..2326804 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2326812..2326826 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2326833 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2326841..2326860) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326843) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2326845..2326966) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2326872..2326879) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2326946 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2326955..2326974) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2326963..2326982 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326966) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2326968..2327107) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2326969..2327073 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2326969 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" promotor_-35 complement(2326988..2326994) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2327037..2327044 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2327058..2327077 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2327075..2329224 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2327075 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" CDS complement(2327133..2328248) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" gene complement(2327133..2328248) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" downshifts complement(2327152) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" S_feature complement(2328249..2328446) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2328447..2330258) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" gene complement(2328447..2330258) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" promotor_-35 2329853..2329859 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2329869 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" promotor_-10 2329871..2329890 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2329898..2330194 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" gene 2329898..2330194 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" CDS complement(2330292..2330786) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" gene complement(2330292..2330786) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" promotor_-10 complement(2330759..2330777) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2330770) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" S_feature complement(2330787..2330900) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2330789..2330797) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2330795..2330800 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2330816..2330834 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2330831 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2330885..2330903) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2330900) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" S_feature complement(2330902..2330979) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2330919..2330924) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2330945..2330964) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2330979) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" promotor_-35 complement(2330980..2330983) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2331040..2331852) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" gene complement(2331040..2331852) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" CDS complement(2331878..2332516) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" gene complement(2331878..2332516) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" S_feature complement(2332517..2332648) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2332642..2332661) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2332649..2334688) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" gene complement(2332649..2334688) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" upshifts complement(2332651) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" promotor_-35 complement(2332676..2332683) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2332695) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" downshifts complement(2332761) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" CDS complement(2334681..2335568) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" gene complement(2334681..2335568) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" misc_RNA complement(2335651..2335825) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" gene complement(2335651..2335825) /gene="tboG" /locus_tag="BSU_misc_RNA_39" downshifts complement(2335685) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" promotor_-35 2335800..2335805 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2335821..2335839 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2335829..2335848) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2335831..2337243 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2335831 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" upshifts complement(2335841) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" promotor_-35 complement(2335863..2335870) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2335865..2336632) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" gene complement(2335865..2336632) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" CDS complement(2336669..2336812) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" gene complement(2336669..2336812) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" S_feature complement(2336813..2336959) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2336960..2337865) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" gene complement(2336960..2337865) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" CDS complement(2337846..2338256) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" gene complement(2337846..2338256) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" promotor_-10 complement(2338294..2338313) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2338305) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" S_feature complement(2338307..2338374) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2338328..2338331) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2338375..2338746) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" gene complement(2338375..2338746) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" CDS complement(2338727..2339200) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" gene complement(2338727..2339200) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" CDS complement(2339201..2341336) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" gene complement(2339201..2341336) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" promotor_-35 2341180..2341185 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2341200 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2341201..2341219 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2341415..2342374) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" gene complement(2341415..2342374) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" downshifts complement(2341430) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" CDS complement(2342371..2343567) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" gene complement(2342371..2343567) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" promotor_-10 complement(2342438..2342457) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2342443) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" promotor_-35 complement(2342471..2342478) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2342518..2342536) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2342530) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" promotor_-35 complement(2342551..2342557) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2342745) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" promotor_-10 complement(2342759..2342770) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2342785..2342791) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2343586..2343867) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" gene complement(2343586..2343867) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" CDS complement(2343924..2344343) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" gene complement(2343924..2344343) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" downshifts complement(2343938) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" CDS complement(2344368..2345363) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" gene complement(2344368..2345363) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" CDS complement(2345385..2346698) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" gene complement(2345385..2346698) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" promotor_-10 complement(2346734..2346749) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2346751) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" promotor_-35 complement(2346762..2346771) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2346829..2347275) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" gene complement(2346829..2347275) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" downshifts complement(2346842) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" downshifts complement(2347040) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" CDS complement(2347290..2347463) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" gene complement(2347290..2347463) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" misc_feature 2347399..2347403 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2347404 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2347524..2347543) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2347539) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" promotor_-35 complement(2347557..2347564) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2347582..2347587 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2347602 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" promotor_-10 2347603..2347621 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2347636..2348559 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" gene 2347636..2348559 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" CDS complement(2348596..2349951) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" gene complement(2348596..2349951) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" downshifts complement(2348602) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" CDS complement(2349951..2350721) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" gene complement(2349951..2350721) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" CDS complement(2350744..2351679) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" gene complement(2350744..2351679) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" CDS complement(2351704..2352831) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" gene complement(2351704..2352831) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" misc_feature 2352748..2352751 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2352759 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2352832..2353009) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2352871..2352961 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene 2352871..2352961 /gene="surC" /locus_tag="BSU_misc_RNA_79" CDS complement(2353031..2354866) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" gene complement(2353031..2354866) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" downshifts complement(2353054) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" CDS complement(2354890..2355453) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" gene complement(2354890..2355453) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" S_feature complement(2355454..2355524) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2355525..2356556) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" gene complement(2355525..2356556) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" promotor_-10 complement(2356597..2356616) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2356610) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" promotor_-35 complement(2356631..2356638) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2356637..2357776) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" gene complement(2356637..2357776) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" promotor_-10 complement(2357649..2357660) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2357653) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" promotor_-35 complement(2357674..2357680) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2357829..2359667) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" gene complement(2357829..2359667) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" downshifts complement(2357851) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" promotor_-10 complement(2359702..2359721) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2359719) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" promotor_-35 complement(2359737..2359741) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2359801..2360139) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" gene complement(2359801..2360139) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" downshifts complement(2359807) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" CDS complement(2360156..2361361) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" gene complement(2360156..2361361) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" promotor_-10 complement(2361381..2361399) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2361393) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" promotor_-35 complement(2361415..2361420) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2361424..2362530) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" gene complement(2361424..2362530) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" promotor_-10 complement(2362558..2362569) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2362565) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" promotor_-35 complement(2362584..2362590) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2362629..2362632 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2362645 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" promotor_-10 2362648..2362667 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2362659..2362733 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2362734..2363000 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" gene 2362734..2363000 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" downshifts 2362989 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" CDS complement(2363015..2364058) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" gene complement(2363015..2364058) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" downshifts complement(2363060) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" promotor_-10 complement(2364087..2364106) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2364098..2364247) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" gene complement(2364098..2364247) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" upshifts complement(2364099) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" promotor_-35 complement(2364120..2364124) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2364122..2364461) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2364165) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" promotor_-35 2364234..2364240 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2364254..2364273 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2364255 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" CDS 2364288..2364422 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" gene 2364288..2364422 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" downshifts 2364416 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" CDS complement(2364462..2366792) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" gene complement(2364462..2366792) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" promotor_-10 complement(2364479..2364498) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2364495) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" promotor_-35 complement(2364512..2364521) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2366796..2367365) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" gene complement(2366796..2367365) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" promotor_-10 complement(2367392..2367411) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2367402) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" promotor_-35 complement(2367426..2367433) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2367432..2368049) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" gene complement(2367432..2368049) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" promotor_-35 2368070..2368075 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2368087 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" promotor_-10 2368091..2368109 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2368110..2368124) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2368112) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" S_feature complement(2368114..2368961) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2368133..2368137) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2368133..2368954 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" gene 2368133..2368954 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" promotor_-10 complement(2368949..2368968) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2368955..2369035 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2368962) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" promotor_-35 complement(2368982..2368989) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2368995 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" CDS complement(2369020..2369763) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" gene complement(2369020..2369763) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" downshifts complement(2369050) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" CDS complement(2369760..2370116) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" gene complement(2369760..2370116) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" CDS complement(2370134..2370694) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" gene complement(2370134..2370694) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" CDS complement(2370684..2371253) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" gene complement(2370684..2371253) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" CDS complement(2371265..2371555) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" gene complement(2371265..2371555) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" CDS complement(2371549..2372391) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" gene complement(2371549..2372391) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" downshifts 2372383 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" CDS complement(2372409..2373509) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" gene complement(2372409..2373509) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" CDS complement(2373513..2374031) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" gene complement(2373513..2374031) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" promotor_-10 complement(2373941..2373958) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2373955) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" promotor_-35 complement(2373974..2373977) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2374032..2374593) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2374065) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" promotor_-35 2374256..2374263 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2374274..2374374 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2374274..2374293 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2374274 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" misc_RNA complement(2374324..2374582) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene complement(2374324..2374582) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" CDS 2374375..2374533 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" gene 2374375..2374533 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" S_feature 2374534..2374780 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2374581..2374600) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2374592) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" promotor_-35 complement(2374616..2374620) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2374644..2374791) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2374681) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" downshifts 2374737 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" S_feature 2374782..2375835 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2374786..2374805) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2374791) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" promotor_-35 complement(2374818..2374827) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2374839..2375570) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" gene complement(2374839..2375570) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" promotor_-10 complement(2375589..2375608) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375605) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" S_feature complement(2375607..2375715) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2375622..2375628) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2375716..2375734) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375737) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" promotor_-35 complement(2375749..2375754) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2375822..2376574) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" gene complement(2375822..2376574) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" downshifts complement(2375825) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" promotor_-35 2375953..2375959 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2375973..2375991 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2375980 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2376584..2376603) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376603) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" promotor_-35 complement(2376617..2376625) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2376669..2376676 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2376691..2376710 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2376695..2376760 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2376695 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" CDS 2376761..2377387 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" gene 2376761..2377387 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" downshifts 2377355 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" CDS complement(2377406..2378299) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" gene complement(2377406..2378299) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" downshifts complement(2377431) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" promotor_-35 2378482..2378488 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2378500..2378519 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2378500 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" CDS 2378551..2379273 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" gene 2378551..2379273 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" CDS complement(2379306..2379716) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" gene complement(2379306..2379716) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" downshifts complement(2379331) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" promotor_-10 complement(2379736..2379754) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2379738) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" promotor_-35 complement(2379770..2379775) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2379839..2379847 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2379860 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" promotor_-10 2379861..2379880 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2379912..2380382 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" gene 2379912..2380382 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo downshifts 2380102 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" downshifts 2380234 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" CDS complement(2380290..2381792) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" gene complement(2380290..2381792) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" downshifts complement(2380306) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" promotor_-10 complement(2381899..2381917) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2381917) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" S_feature complement(2381919..2382220) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2381934..2381939) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2382241..2382660) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" gene complement(2382241..2382660) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" downshifts complement(2382265) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" CDS complement(2382672..>2382800) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2382672..>2382800) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2382796,2382803) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2382797..2382802 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2382798..2383184 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2382798..2383184 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2383151..2383169) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2383166..2383582 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" gene 2383166..2383582 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo misc_feature 2383171..2383185 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2383179) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 2383190 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" downshifts 2383566 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" CDS 2383582..2383698 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" gene 2383582..2383698 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" S_feature 2383611..2384945 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2383729) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" CDS complement(2383807..2383971) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" gene complement(2383807..2383971) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" promotor_-10 complement(2383901..2383920) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383927) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" promotor_-35 complement(2383935..2383942) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2384105) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" CDS complement(2384516..2384932) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" gene complement(2384516..2384932) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" CDS complement(2384978..2386276) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" gene complement(2384978..2386276) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" CDS complement(2386263..2386958) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" gene complement(2386263..2386958) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" misc_feature complement(2387024..2387041) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2387033) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" promotor_-35 2387119..2387125 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2387132..2387150 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2387147 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2387226..2388443 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" gene 2387226..2388443 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" promotor_-35 2387685..2387692 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2387707..2387726 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2387723 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2388362..2388610 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" gene 2388362..2388610 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" S_feature complement(2388539..2389586) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2388955..2389512 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" gene 2388955..2389512 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" S_feature 2389513..2389635 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2389588..2390002) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2389631) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" CDS complement(2390003..2390527) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" gene complement(2390003..2390527) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" promotor_-35 2390375..2390382 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2390393..2390412 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2390407 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2390528..2390615) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2390610..2390629) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2390615) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" S_feature complement(2390617..2390770) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2390644..2390651) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2390771..2391247) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390525.2" /db_xref="EnsemblGenomes-Gn:BSU26480" /db_xref="EnsemblGenomes-Tr:CAB14589" /db_xref="GOA:P54438" /db_xref="InterPro:IPR025671" /db_xref="SubtiList:BG11777" /db_xref="UniProtKB/Swiss-Prot:P54438" /translation="MVYFVAFFCFAITLHNIEEAIWLPEWSQQSSKFQKPVTSNEFHF AVIVITMLAYLSAFGFLYMPESDIAKWIFIGFLGSMVINAIFPHLIATVVMKKYAPGL LTGLLLNIPVNSLVIYQMFLKNLIVWKELIISTLVVGIILLALIPLLFKVGDKVSP*" gene complement(2390771..2391247) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" promotor_-10 complement(2391283..2391302) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391297) /Source="Nicolas_upshifts" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" S_feature complement(2391299..2391829) /Source="Nicolas_S_feature" /locus_tag="new_2709471_2710001_c" /HighExp="Diami, dia15, S8, G180, Etha, G135, S6, S0, G150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S990" promotor_-35 complement(2391316..2391323) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2391830..2392615) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_390526.1" /db_xref="EnsemblGenomes-Gn:BSU26490" /db_xref="EnsemblGenomes-Tr:CAB14590" /db_xref="GOA:P54437" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG11776" /db_xref="UniProtKB/Swiss-Prot:P54437" /translation="MDIAFITTLFIIGFIGAFISGMIGIGGAVINYPMLLYIPSLVGV MSLTAHEVSGIGAIQVFFATLGGVWAYRKSGLINKTLIIYMGSSILLGSVLGSYFSHY ISEKGINFIYGILAIIAVILMFIPKKGQKGQEHSEDKEVIFNKWLASSLAFIIGGVSG ILGAGGAFILVPIMLSILNIPVRVTVASSLAITFLSSIGATVGKVITGQVLFVPALVL MITSLIASPIGASVGQKVNTKFLQWVLAQLIGATAIKIWLELL*" gene complement(2391830..2392615) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" CDS complement(2392676..2392903) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9555915; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur-carrier protein" /protein_id="NP_390527.1" /db_xref="EnsemblGenomes-Gn:BSU26500" /db_xref="EnsemblGenomes-Tr:CAB14591" /db_xref="GOA:P54436" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR036868" /db_xref="SubtiList:BG11775" /db_xref="UniProtKB/Swiss-Prot:P54436" /translation="MKSDKVLDAKGLACPMPIVRTKKAMNELESGQILEVHATDKGAK NDLTAWSKSGGHDLLEQTDEGDILKFWIQKG*" gene complement(2392676..2392903) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" downshifts complement(2392700) /Source="Nicolas_upshifts" /id="D1361" /incds=0 /nref=4 /ntot=22 /MaxReadThrough="5.31659" /MaxDrop="3.95633" /score="-3.35079978" /energy="-23.7" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=3085 /isTUend="FALSE" CDS complement(2392937..2394070) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase / hydrolase" /protein_id="NP_390528.2" /db_xref="EnsemblGenomes-Gn:BSU26510" /db_xref="EnsemblGenomes-Tr:CAB14592" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036866" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11774" /db_xref="UniProtKB/Swiss-Prot:P54435" /translation="MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDF DHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGM KAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFA KGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDII IGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLR KTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHL VTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR*" gene complement(2392937..2394070) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" misc_feature complement(2393772..2393787) /Source="Nicolas_upshift_promotors" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2393783) /Source="Nicolas_upshifts" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2394071..2394404) /Source="Nicolas_S_feature" /locus_tag="new_2712243_2712576_c" /HighExp="Diami, dia15, Sw, BC, S0, G180, dia5, G135, M9-stat, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99950300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S991" CDS complement(2394405..2394962) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhodanese-related sulfur transferase" /protein_id="NP_390530.1" /db_xref="EnsemblGenomes-Gn:BSU26530" /db_xref="EnsemblGenomes-Tr:CAB14594" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036868" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11772" /db_xref="UniProtKB/Swiss-Prot:P54433" /translation="MMKATIVLDAKGLACPMPIVKTKKRMKDLKAGEVLEIHATDKGS TADLEAWAKSTGHEYLGTEAEGEILRHFLRKGGEHSSENASSIPEISLEAFKQKVDSD ESLNILDVREIEEYEKAHIPGVVHIPLGEVEKRANELNENDEIYIICHSGRRSEMAAR TMKKQGFKKVINVVPGMRDWTGKTE*" gene complement(2394405..2394962) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" S_feature complement(2394963..2395147) /Source="Nicolas_S_feature" /locus_tag="new_2713135_2713319_c" /HighExp="Diami, dia15, Sw, BC, S8, dia5, G180, S7, S0, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12629799999999999" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S992" CDS complement(2395148..2395630) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein involved in sulfur metabolism (DsrE-like)" /protein_id="NP_390531.1" /db_xref="EnsemblGenomes-Gn:BSU26540" /db_xref="EnsemblGenomes-Tr:CAB14595" /db_xref="InterPro:IPR027396" /db_xref="InterPro:IPR032836" /db_xref="SubtiList:BG11771" /db_xref="UniProtKB/Swiss-Prot:P54432" /translation="MTEQTKRTTIVLFSGDYDKAMAAYIIANGAAAYDHEVTIFHTFW GFNALRKEELIPVKKGFLEKMFGKMMPRGADKMGLSKMNFAGMGPKMIKNVMKKHNVL TLPQLIEMAQEQGVKLVACTMTMDLLGLQEKELLDDIDYAGVAAYLADAEEGSVNLFI *" gene complement(2395148..2395630) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" S_feature complement(2395631..2395739) /Source="Nicolas_S_feature" /locus_tag="new_2713803_2713911_c" /HighExp="Diami, dia15, Sw, BC, dia5, S8, G180, S6, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S993" CDS complement(2395777..2395968) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21339296; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative metal-sensitive transcriptional regulator involved in sulfur metabolism" /protein_id="NP_390532.1" /db_xref="EnsemblGenomes-Gn:BSU26550" /db_xref="EnsemblGenomes-Tr:CAB14596" /db_xref="GOA:P54431" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG11770" /db_xref="UniProtKB/Swiss-Prot:P54431" /translation="MMEQGKDCREVVTQLAASRNAIDRAMGLIVSTNLEHCVRESLEK GEDTQNLVKEAVDLLVKSR*" gene complement(2395777..2395968) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" downshifts complement(2395784) /Source="Nicolas_upshifts" /id="D1362" /incds=0 /nref=153 /ntot=252 /MaxReadThrough="8.17686" /MaxDrop="5.42995" /score="-6.39526496" /energy="-7.9" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=1 /isTUend="TRUE" S_feature complement(2395969..2396058) /Source="Nicolas_S_feature" /locus_tag="new_2714141_2714230_c" /HighExp="Diami, dia15, S6, S7, S8, Etha, dia5, S5, BC, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="1, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S994" CDS complement(2396059..2396376) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="PSEUDO:CAX52666.1" /translation="MIIIATYRRYYPITGISCIHKDKLEAMDITILDIRHYNDVANFS DNIILNIPYAYLKRFYLEIPRDKIHIIARDRVELNLGVRFLKRKGIHVNSYELATCKC KNK*" gene complement(2396059..2396376) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /pseudo promotor_-10 complement(2396165..2396184) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2396181) /Source="Nicolas_upshifts" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" promotor_-35 complement(2396197..2396203) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2396418..2396633) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52667.1" /translation="MINKADLKLNRLIALFEFLLAELALSNVSIFSIRGYRNESISSK KVTFTLDYIPMGVYYCFVNKQRVNKVV*" gene complement(2396418..2396633) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /pseudo promotor_-10 complement(2396446..2396465) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2396460) /Source="Nicolas_upshifts" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" promotor_-35 complement(2396480..2396487) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2396634..2396760) /Source="Nicolas_S_feature" /locus_tag="new_2714806_2714932_c" /HighExp="S6, S7, S8, S5, BT, B36, G/S, BC, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.114547" /TUshortSig="SigK, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S995" CDS complement(2396761..2397321) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_390533.1" /db_xref="EnsemblGenomes-Gn:BSU26560" /db_xref="EnsemblGenomes-Tr:CAB14597" /db_xref="GOA:P54430" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG11769" /db_xref="UniProtKB/Swiss-Prot:P54430" /translation="MYYNPFSPQCYYYVTVPMYNDGRSVYWTIPNEMEKVHRGADLRS SYEDRNLLLKDYGPKPFVVNINRATKQNNTFRTALWTGKHFQVTLMSLGIGEDIGLEI HPNVDQFLRIEQGRGIVKMGKSKDHLNFQRNVYDDSAIVVPAGTWHNVINTGNTPLKL YSIYAPPNHPFGTVHETKADAVAAED*" gene complement(2396761..2397321) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" CDS complement(2397338..2397514) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513984.1" /translation="MLTKASEIQHLENDYKVGDKLFIHESNGDRTFIFVFNMSFLDLA HSLNKCIGYYHKNL*" gene complement(2397338..2397514) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" promotor_-10 complement(2397348..2397367) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397359) /Source="Nicolas_upshifts" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" S_feature complement(2397361..2397546) /Source="Nicolas_S_feature" /locus_tag="new_2715533_2715718_c" /HighExp="BC, Sw, S3, dia15, Etha, S4, S5, H2O2, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49093999999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S996" promotor_-35 complement(2397380..2397389) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2397547..2397693) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390534.1" /db_xref="EnsemblGenomes-Gn:BSU26570" /db_xref="EnsemblGenomes-Tr:CAB14598" /db_xref="SubtiList:BG11768" /db_xref="UniProtKB/Swiss-Prot:P54429" /translation="MLLKNWPSRRIQRDKSKRAGIGGTNNRIPYTLLLCYVNVQKPFR IVDL*" gene complement(2397547..2397693) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" CDS complement(2397863..2398684) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7608059, 9083003, 10200972, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7608059, 9083003, 10200972, 21954605; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (polyamine metabolism)" /protein_id="NP_390535.1" /db_xref="EnsemblGenomes-Gn:BSU26580" /db_xref="EnsemblGenomes-Tr:CAB14599" /db_xref="GOA:P39842" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="SubtiList:BG10904" /db_xref="UniProtKB/Swiss-Prot:P39842" /translation="MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGY RYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELK QLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHE VQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYE IGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV*" gene complement(2397863..2398684) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" promotor_-35 2398692..2398699 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2398694..2398713) /Source="Nicolas_upshift_promotors" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2398711) /Source="Nicolas_upshifts" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2398713..2400717) /Source="Nicolas_S_feature" /locus_tag="new_2716885_2718889_c" /HighExp="BC, Sw, Salt, Mal, T4.0H, M9-stat, T3.30H, G180, G135, MG 5" /AntisenseName="blt" /AntisenseCor="0.56943492854420497" /AntisenseRegPval="-23.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S997" promotor_-10 2398715..2398734 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2398723 /Source="Nicolas_upshifts" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" CDS 2398801..2400003 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /function="16.1: Circulate" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (promiscuous, acetylated polyamines efflux)" /protein_id="NP_390536.1" /db_xref="EnsemblGenomes-Gn:BSU26590" /db_xref="EnsemblGenomes-Tr:CAB14600" /db_xref="GOA:P39843" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR004734" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10905" /db_xref="UniProtKB/Swiss-Prot:P39843" /translation="MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSG STMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFY FSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF GIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYF IAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLV NKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMA GNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEK KNDAAALN*" gene 2398801..2400003 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" CDS 2400172..2400630 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /EC_number="2.3.1.57" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermine/spermidine acetyltransferase" /protein_id="NP_390537.1" /db_xref="EnsemblGenomes-Gn:BSU26600" /db_xref="EnsemblGenomes-Tr:CAB14601" /db_xref="GOA:P39909" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027455" /db_xref="SubtiList:BG10906" /db_xref="UniProtKB/Swiss-Prot:P39909" /translation="MSINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHY YKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRVWLDRFFIDERYQGKGLGKKMLKALI QHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL*" gene 2400172..2400630 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" downshifts complement(2400762) /Source="Nicolas_upshifts" /id="D1363" /incds=0 /nref=77 /ntot=211 /MaxReadThrough="5.09534" /MaxDrop="4.8114" /score="-0.00168005652" /energy="-10.7" /TU="U2049" /idTUdmin="U2051" /TUdmin=3845 /isTUend="FALSE" CDS complement(2400787..2402091) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative membrane associated protein" /protein_id="NP_390538.1" /db_xref="EnsemblGenomes-Gn:BSU26610" /db_xref="EnsemblGenomes-Tr:CAB14602" /db_xref="GOA:P54428" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11767" /db_xref="UniProtKB/Swiss-Prot:P54428" /translation="MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKG AISAKKVITHLDEYLSACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVL ILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKE IMIPRREIVAISSEDSYETIVKIIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDT DQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVDEYGGTSGLVTAED ILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGG WFMTQQIDAAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE*" gene complement(2400787..2402091) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" S_feature complement(2402092..2402171) /Source="Nicolas_S_feature" /locus_tag="new_2720264_2720343_c" /HighExp="BC, Sw, MG 15, Mal, Salt, MG 25, MG-0.2, MG 45, MG 5, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S998" promotor_-10 complement(2402157..2402176) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2402171) /Source="Nicolas_upshifts" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" promotor_-35 complement(2402191..2402198) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2402354..2402497) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097765.1" /db_xref="EnsemblGenomes-Gn:BSU26619" /db_xref="EnsemblGenomes-Tr:CAX52668" /db_xref="InterPro:IPR025417" /db_xref="UniProtKB/Swiss-Prot:C0H458" /translation="MFEGLLFFISAGIVCELAAINRNGRKNIKQQAELIQILKENLYK DIK*" gene complement(2402354..2402497) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" CDS complement(2402515..2403480) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390539.1" /db_xref="EnsemblGenomes-Gn:BSU26620" /db_xref="EnsemblGenomes-Tr:CAB14603" /db_xref="GOA:O07086" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12289" /db_xref="UniProtKB/Swiss-Prot:O07086" /translation="MKKGQLFIGALTCLVASMSWGAMFPVADHALEFVDPFYFSFIRY GVVTIMLVILLLVREGKKSFHLEGKAKWIILFGVMAFTIYNVLIFLGQRLMGKSGIMT ASIAEALMPMLSIVILWGYKHVKPKKYTMISILIAFLGASMVITKGNISFFFSLGDHL FSILFIFIGVLGWVVYTMGGQIFREWSTLRYSTLTCLFGTAITGIMTAILTAQGYVSV PSIKVIAAIKYDFLFMITLPGIIALLSWNYGIKILSSINGILFINFVPITTLLIMVIK GYNITAFDIVGTLFVIIGLILNNIYQRKEDYKQVLQKEKTNLTIT*" gene complement(2402515..2403480) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" promotor_-35 2403518..2403521 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2403536..2403555 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2403563 /Source="Nicolas_upshifts" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" CDS 2403606..2404472 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 22666466, 25437189; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390540.1" /db_xref="EnsemblGenomes-Gn:BSU26630" /db_xref="EnsemblGenomes-Tr:CAB14604" /db_xref="GOA:P71025" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12288" /db_xref="UniProtKB/Swiss-Prot:P71025" /translation="MELRDLQIFKCVAHHKSITGAAKELNYVQSNVTARIKQLENELK TPLFNRHKKGVSLSPEGRKMIEYVNKILKDVEELEQVFLDTEIPSGILKIGTVETVRI LPTIIASYYKKYPNVDLSLQAGLTEELIKKVMNHELDGAFISGPLKHSILEQYDVYTE KLTLVTSNKTFNIEDFSTTPILVFNQGCGYRSRLEQWLKDEGVLPNRMMEFNILETIL NSVALGLGITVVPESAVMHLAVQGKVYCHPLPEKDSCISTIFIRHKDAYLTNSMRSLL KTIVEHKNMSMA*" gene 2403606..2404472 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" S_feature 2404473..2404573 /Source="Nicolas_S_feature" /locus_tag="new_2722645_2722745" /HighExp="HiTm, dia15, LBGstat, LPhT, T0.30H, Diami, Paraq, dia5, H2O2, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.905" /TUlongSig="NA" /TUlongPSig="NA" /label="S999" downshifts 2404531 /Source="Nicolas_upshifts" /id="D1364" /incds=0 /nref=6 /ntot=135 /MaxReadThrough="2.57006" /MaxDrop="3.43983" /score="-6.36950065" /energy="-7" /TU="NA" /idTUdmin="U2050" /TUdmin=0 /isTUend="TRUE" CDS complement(2404595..2405632) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099864, 12100555, 12527699; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_390541.1" /db_xref="EnsemblGenomes-Gn:BSU26640" /db_xref="EnsemblGenomes-Tr:CAB14605" /db_xref="GOA:O07085" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000960" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11980" /db_xref="UniProtKB/Swiss-Prot:O07085" /translation="MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRY DSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLK IKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAY GNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHAS HTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNII WATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGND AEYIVKQMNGE*" gene complement(2404595..2405632) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" downshifts complement(2404607) /Source="Nicolas_upshifts" /id="D1365" /incds=0 /nref=30 /ntot=134 /MaxReadThrough="2.50972" /MaxDrop="5.83595" /score="2.19797168" /energy="-12.5" /TU="NA" /idTUdmin="U2051" /TUdmin=0 /isTUend="TRUE" S_feature complement(2405633..2405719) /Source="Nicolas_S_feature" /locus_tag="new_2723805_2723891_c" /HighExp="LBGtran, dia5, Gly, Diami, LBGstat, M0t45, LBGexp, Lbtran, dia0, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.907, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1000" CDS complement(2405720..2406655) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium/proton-divalent cation antiporter" /protein_id="NP_390542.1" /db_xref="EnsemblGenomes-Gn:BSU26650" /db_xref="EnsemblGenomes-Tr:CAB14606" /db_xref="GOA:O07084" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11931" /db_xref="UniProtKB/Swiss-Prot:O07084" /translation="MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDA GHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEA IERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSD IIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHK GITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH*" gene complement(2405720..2406655) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" promotor_-10 complement(2406690..2406709) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2406697) /Source="Nicolas_upshifts" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" S_feature complement(2406699..2406782) /Source="Nicolas_S_feature" /locus_tag="new_2724871_2724954_c" /HighExp="dia5, Gly, LBGtran, Diami, LBGstat, LBGexp, LoTm, dia0, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1001" promotor_-35 complement(2406724..2406731) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2406763..2406782) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2406782) /Source="Nicolas_upshifts" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" promotor_-35 complement(2406796..2406803) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2406917) /Source="Nicolas_upshifts" /id="D1366" /incds=0 /nref=1 /ntot=41 /MaxReadThrough="3.75163" /MaxDrop="3.57795" /score="38.5313506" /energy="-18.1" /TU="NA" /idTUdmin="U2051" /TUdmin="-2310" /isTUend="FALSE" CDS complement(2406942..2407331) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_390543.1" /db_xref="EnsemblGenomes-Gn:BSU26660" /db_xref="EnsemblGenomes-Tr:CAB14607" /db_xref="GOA:P94502" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG12287" /db_xref="UniProtKB/Swiss-Prot:P94502" /translation="MPLLRFDLIEGRDQSSLKKLLDVAHNVVVEAFDVPQQDRYQIVH EHPENHMIIEDTGLGFNRTKNLVVLSVTSKSRPEEKKQKFYRLLAERLESECGIASTD LIVSIVENDNADWSFGLGEAQFLTGKL*" gene complement(2406942..2407331) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" promotor_-35 2407579..2407586 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2407602..2407621 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2407611 /Source="Nicolas_upshifts" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" CDS 2407665..2408555 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390544.2" /db_xref="EnsemblGenomes-Gn:BSU26670" /db_xref="EnsemblGenomes-Tr:CAB14608" /db_xref="GOA:P94501" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11942" /db_xref="UniProtKB/Swiss-Prot:P94501" /translation="MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQ TKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAA VWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGI LEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPA LSAFLTHMRDHFQIKRPDQS*" gene 2407665..2408555 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" promotor_-35 2408243..2408248 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2408264..2408282 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2408271 /Source="Nicolas_upshifts" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2408713..2409030) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390545.3" /db_xref="EnsemblGenomes-Gn:BSU26680" /db_xref="EnsemblGenomes-Tr:CAB14609" /db_xref="SubtiList:BG12286" /db_xref="UniProtKB/Swiss-Prot:P94500" /translation="MRLYTEYIPNKNKLINQQQYHSDLQDLLHQWILQLLQLDVLPLS NRKYQSSRCHPKSVGEYLIVVRAIDALGNSQPLTSRRNQVSRAMTFVQNSLNEENLHP NID*" gene complement(2408713..2409030) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" CDS complement(2408988..2410310) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8544834, 9287000, 9531631, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8544834, 9287000, 9531631, 15849754, 16850406, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="low-affinity branched-chain amino acid transporter" /protein_id="NP_390546.1" /db_xref="EnsemblGenomes-Gn:BSU26690" /db_xref="EnsemblGenomes-Tr:CAB14610" /db_xref="GOA:P94499" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG11918" /db_xref="UniProtKB/Swiss-Prot:P94499" /translation="MSKKVSASYIIIIGLMLFALFFGAGNLIFPPMLGQLAGKNVWVA NAGFLVTGVGLPLLAITAFVFSGKQNLQSLASRVHPVFGIVFTTILYLAIGPFFAIPR SGNVSFEIGVKPFLSNDASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLT FIGLLVAVALIRPIGTIQAPSKGYTSQAFFKGFQEGYLTLDALVAFVFGIIIVNALKE QGASTKKQLIVVCAKAAAIAAVLLAVMYTALSYMGASSVEELGILENGAEVLAKVSSY YFGSYGSILLGLMITVACLTTSVGLITACSSFFHELFPNISYKKIAVVLSVFSTLVAN IGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISLFDGLK AAGIKIEVVNRIFTQILPMYNIGLGWLIPAIAGGICGYILSIFRTKTS*" gene complement(2408988..2410310) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" CDS complement(2410475..2410807) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390547.1" /db_xref="EnsemblGenomes-Gn:BSU26700" /db_xref="EnsemblGenomes-Tr:CAB14611" /db_xref="GOA:O07923" /db_xref="InterPro:IPR008407" /db_xref="SubtiList:BG11916" /db_xref="UniProtKB/Swiss-Prot:O07923" /translation="MTMTMTQQMITIAMVVLGTMLTRFLPFMIFPSGKPTPKYVQYLG KVLPSAVIGLLVIYCLKDVSLLSGSHGIPELVGAAAVVLLHLWKKNMLLSIAGGTVVY MVLVQLVF*" gene complement(2410475..2410807) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" CDS complement(2410804..2411568) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 15849754, 16850406, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390548.1" /db_xref="EnsemblGenomes-Gn:BSU26710" /db_xref="EnsemblGenomes-Tr:CAB14612" /db_xref="GOA:O07942" /db_xref="InterPro:IPR004471" /db_xref="InterPro:IPR011606" /db_xref="SubtiList:BG11915" /db_xref="UniProtKB/Swiss-Prot:O07942" /translation="MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFL FLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNA RHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNH LYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVA SLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV*" gene complement(2410804..2411568) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" CDS complement(2411581..2412054) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 9287000, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 9287000, 26473603; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the azlBCD operon" /protein_id="NP_390549.1" /db_xref="EnsemblGenomes-Gn:BSU26720" /db_xref="EnsemblGenomes-Tr:CAB14613" /db_xref="GOA:O07920" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11914" /db_xref="UniProtKB/Swiss-Prot:O07920" /translation="MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKN LVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTL TGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM*" gene complement(2411581..2412054) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" CDS complement(2412388..2412663) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative ribonuclease inhibitor" /protein_id="NP_390550.1" /db_xref="EnsemblGenomes-Gn:BSU26730" /db_xref="EnsemblGenomes-Tr:CAB14614" /db_xref="GOA:O07938" /db_xref="InterPro:IPR000468" /db_xref="InterPro:IPR035905" /db_xref="SubtiList:BG12285" /db_xref="UniProtKB/Swiss-Prot:O07938" /translation="MRKIIIDGRDFENIEVLHDDLKDKLDFPDYYGRNLDALWDCLTG WVDLPLTLVLKNFEFSNTFLGSYADDVLEVIQEAQEELKDEFKIIIE*" gene complement(2412388..2412663) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" misc_feature complement(2412675..2412694) /Source="Nicolas_upshift_promotors" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2412681) /Source="Nicolas_upshifts" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2412749..2412934) /Source="Nicolas_S_feature" /locus_tag="new_2730921_2731106_c" /HighExp="BT, S4, S8, S3, S5, S7, S6, LoTm, B36, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S1002" CDS complement(2412935..2414167) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9778370, 12354229, 28898812" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9778370, 12354229, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450" /protein_id="NP_390551.1" /db_xref="EnsemblGenomes-Gn:BSU26740" /db_xref="EnsemblGenomes-Tr:CAB14615" /db_xref="GOA:O08469" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG11929" /db_xref="UniProtKB/Swiss-Prot:O08469" /translation="MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM KWKGNFLMRALEELPISF*" gene complement(2412935..2414167) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" CDS complement(2414217..2414375) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; C-terminal part of YrdD" /db_xref="PSEUDO:CAX52669.1" /translation="MEVLGVSPFYQGKSLGSKMINDCLISFISKCGDGILALIMNTDL NGSFYKSS*" gene complement(2414217..2414375) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /pseudo CDS complement(2414372..2414575) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; internal part of YrdD" /db_xref="SubtiList:BG12284" /translation="MHKVLTRAYFKKHFFFVGIQNGEMVVAALLKHRDKPDIKLDRLY SSRGDNINQNGAKKFSKSLKEPA*" gene complement(2414372..2414575) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /pseudo promotor_-10 complement(2414536..2414554) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2414553) /Source="Nicolas_upshifts" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" CDS complement(2414560..2414709) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; N-terminal part of YrdD" /db_xref="SubtiList:BG14036" /translation="MFLYRQARADEVSKVAKLFHQSFNQYPFMDLLVKREKKIIHLFL KCIKY*" gene complement(2414560..2414709) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /pseudo promotor_-35 complement(2414569..2414574) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2414793) /Source="Nicolas_upshifts" /id="D1367" /incds=0 /nref=140 /ntot=216 /MaxReadThrough="2.2276" /MaxDrop="4.5127" /score="5.01317133" /energy="-16.7" /TU="NA" /idTUdmin="U2057" /TUdmin=0 /isTUend="TRUE" CDS complement(2414808..2415371) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390553.1" /db_xref="EnsemblGenomes-Gn:BSU26760" /db_xref="EnsemblGenomes-Tr:CAB14617" /db_xref="GOA:O07081" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12283" /db_xref="UniProtKB/Swiss-Prot:O07081" /translation="MEEKKALIIVDVQKAFDDKKWGERNNVKAEENISKILELWREKG WTVIYIQHTSDKPHSLFHPKNEGFAIKEIVKPMDEEVIITKTVNSSFIGTNLEEFLKL NEITTVVITGLTTPHCVSTTTRMSGNLGFDTYLISDATAAFGMRDQNDTYYDAATIHN ISLATLHDEFATILTTDQLINDFIKTH*" gene complement(2414808..2415371) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" downshifts 2415289 /Source="Nicolas_upshifts" /id="D1368" /incds=1 /nref=44 /ntot=194 /MaxReadThrough="1.72227" /MaxDrop="3.37915" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin="-4488" /isTUend="FALSE" promotor_-10 complement(2415401..2415420) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2415409) /Source="Nicolas_upshifts" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" promotor_-35 complement(2415435..2415442) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2415600..2415971) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390554.1" /db_xref="EnsemblGenomes-Gn:BSU26770" /db_xref="EnsemblGenomes-Tr:CAB14618" /db_xref="GOA:O07080" /db_xref="InterPro:IPR021214" /db_xref="SubtiList:BG12282" /db_xref="UniProtKB/Swiss-Prot:O07080" /translation="MEKLNQTNLLLRFTLEIAALISLGVYAWISFNGYFKYVLTLVLP IAVMIVWSVFAVPHDPSRSGQTVIAVNGVTRLVIELLIFAMAVAALYFSYLKPVSIVF LCLIILHYIISAERIKWLLNQ*" gene complement(2415600..2415971) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" S_feature complement(2415972..2416201) /Source="Nicolas_S_feature" /locus_tag="new_2734144_2734373_c" /HighExp="BMM, GM 120, GM 90, SMM, MG 150, GM 60, MG 120, M9-tran, Glu, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48162700000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1003" promotor_-10 complement(2416183..2416202) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-10" upshifts complement(2416199) /Source="Nicolas_upshifts" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" promotor_-35 complement(2416216..2416223) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-35" downshifts complement(2416767) /Source="Nicolas_upshifts" /id="D1369" /incds=0 /nref=174 /ntot=248 /MaxReadThrough="2.42722" /MaxDrop="5.81863" /score="7.90390368" /energy="-10.3" /TU="NA" /idTUdmin="U2059" /TUdmin=6 /isTUend="TRUE" CDS complement(2416781..2417284) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390555.1" /db_xref="EnsemblGenomes-Gn:BSU26780" /db_xref="EnsemblGenomes-Tr:CAB14619" /db_xref="GOA:O07079" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12281" /db_xref="UniProtKB/Swiss-Prot:O07079" /translation="MFQTLDHFLKSWEFEADATQKLLNSLTDESLKQEITSQNWTLGR IAWHTVAAIGIITSNTDLTFQAPAEDYPVPTSAQFIADSYHQASNAFVQALKTQWTDH TLQERINFIGQQMPNGSLLMFLIQHQNHHRGQMTVLMRQAGLTVPGIYGPAKEEWAKF GLEAPKM*" gene complement(2416781..2417284) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" S_feature complement(2417285..2417509) /Source="Nicolas_S_feature" /locus_tag="new_2735457_2735681_c" /HighExp="Etha, Lbstat, M0t90, M40t90, LoTm, M9-stat, Gly, S2, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1004" CDS complement(2417510..2418364) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /EC_number="2.7.7.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8293959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8293959; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aminoglycoside 6-adenylyltransferase" /protein_id="NP_390556.1" /db_xref="EnsemblGenomes-Gn:BSU26790" /db_xref="EnsemblGenomes-Tr:CAB14620" /db_xref="GOA:P17585" /db_xref="InterPro:IPR007530" /db_xref="PDB:2PBE" /db_xref="SubtiList:BG11037" /db_xref="UniProtKB/Swiss-Prot:P17585" /translation="MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYD ISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDL TLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFW MVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRY LSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYT EGIYCSVK*" gene complement(2417510..2418364) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" S_feature complement(2418365..2418467) /Source="Nicolas_S_feature" /locus_tag="new_2736537_2736639_c" /HighExp="M9-stat, T3.0H, T0.30H, T1.30H, T2.30H, Lbtran, T3.30H, T1.0H, M0t90, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1005" promotor_-10 complement(2418448..2418467) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2418465) /Source="Nicolas_upshifts" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" promotor_-35 complement(2418482..2418485) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2418636..2418643 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2418657..2418676 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2418672 /Source="Nicolas_upshifts" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" S_feature 2418677..2418742 /Source="Nicolas_S_feature" /locus_tag="new_2736849_2736914" /HighExp="LoTm, BC, S1, S2, C90, T4.0H, HiOs, T5.0H, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.894" /TUlongSig="NA" /TUlongPSig="NA" /label="S1006" CDS 2418743..2419786 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /EC_number="1.13.12.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9501443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative anionic nitroalkane monoxygenase" /protein_id="NP_390557.1" /db_xref="EnsemblGenomes-Gn:BSU26800" /db_xref="EnsemblGenomes-Tr:CAB14621" /db_xref="GOA:O05413" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12305" /db_xref="UniProtKB/Swiss-Prot:O05413" /translation="MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASG YLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTS VQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLM EERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHR GVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIV NKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVK QLLNQLCQEDIKI*" gene 2418743..2419786 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" downshifts 2419784 /Source="Nicolas_upshifts" /id="D1370" /incds=0 /nref=22 /ntot=198 /MaxReadThrough="1.3622" /MaxDrop="5.04821" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin=7 /isTUend="TRUE" promotor_-35 2420071..2420078 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-35" upshifts 2420085 /Source="Nicolas_upshifts" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" promotor_-10 2420092..2420111 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-10" CDS 2420136..2420933 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /EC_number="5.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12829290, 15212785, 15347750, 17720142, 25777674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12829290, 15212785, 15347750, 17720142, 25777674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390558.1" /db_xref="EnsemblGenomes-Gn:BSU26810" /db_xref="EnsemblGenomes-Tr:CAB14622" /db_xref="GOA:O05412" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="SubtiList:BG12306" /db_xref="UniProtKB/Swiss-Prot:O05412" /translation="MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSK GKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINK CTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKII KYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLA DRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH*" gene 2420136..2420933 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" promotor_-35 2421239..2421243 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2421257..2421276 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2421267 /Source="Nicolas_upshifts" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" promotor_-10 complement(2421291..2421305) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2421305) /Source="Nicolas_upshifts" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2421314..2421318) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2421314..2422021 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390559.1" /db_xref="EnsemblGenomes-Gn:BSU26820" /db_xref="EnsemblGenomes-Tr:CAB14623" /db_xref="InterPro:IPR029143" /db_xref="SubtiList:BG12307" /db_xref="UniProtKB/Swiss-Prot:O05411" /translation="MMKKGLLAGALTATVLFGTCAVDVPGIISPKTAEAASQLTDGIG GRAYLNSNGAILVTKIQLPSSTQVSNGTAYIYSGFSGGTESDIGFQYSDKYNVWKPYM KVGSKGQDQVQYLEGGSQFTNTKGFRPGSTVQLTIYKNLNGNTRATYWGTNNAGYNGR LISEISKTNVGSISKWKALATVATTGSRQSIKSNFSTSFTNITIDNKAITPVIDTQDF AKVTVSGNSVSLSVVKN*" gene 2421314..2422021 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" downshifts 2422021 /Source="Nicolas_upshifts" /id="D1371" /incds=0 /nref=4 /ntot=168 /MaxReadThrough="5.98921" /MaxDrop="2.677" /score="15.7112026" /energy="-8.2" /TU="U2062" /idTUdmin="U2064" /TUdmin="-660" /isTUend="FALSE" S_feature 2422066..2422239 /Source="Nicolas_S_feature" /locus_tag="new_2740238_2740411" /HighExp="Lbstat, M0t90, M40t90, BT, S0, ferm, S2, M9-stat, Lbtran, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig=1 /label="S1007" promotor_-35 2422221..2422222 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2422238..2422257 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2422241..2422569 /Source="Nicolas_S_feature" /locus_tag="new_2740413_2740741" /HighExp="Lbstat, M0t90, BT, M40t90, S2, S0, ferm, T2.0H, M9-stat, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99711000000000005" /TUshortSig="SigA, SigA" /TUshortPSig="0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1008" upshifts 2422241 /Source="Nicolas_upshifts" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" CDS 2422345..2422506 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90581.1" /translation="MYFHKRGMASYSSIASGRLANDWPRTTHHFETDSFQNHKYDPIT NKDQLAVQP*" gene 2422345..2422506 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /pseudo promotor_-35 2422535..2422544 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2422557..2422576 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2422571..2422722 /Source="Nicolas_S_feature" /locus_tag="new_2740743_2740894" /HighExp="BT, S8, B36, S7, Lbstat, G/S, Pyr, M0t90, B60, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94474599999999997" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1009" upshifts 2422571 /Source="Nicolas_upshifts" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" CDS 2422597..2422674 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /experiment="publication(s) with functional evidences, PMID:20709900" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="expressed polypeptide of unknown function" /protein_id="YP_009513985.1" /db_xref="EnsemblGenomes-Gn:BSU26826" /db_xref="EnsemblGenomes-Tr:CCQ48602" /db_xref="GOA:L8E9J8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8E9J8" /translation="MRSFPLIVVLFILLIIVGTSFFGGY*" gene 2422597..2422674 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" downshifts 2422679 /Source="Nicolas_upshifts" /id="D1372" /incds=0 /nref=23 /ntot=198 /MaxReadThrough="3.86249" /MaxDrop="4.0885" /score="28.4802594" /energy="-18.1" /TU="U2062,U2065" /idTUdmin="U2064" /TUdmin="-2" /isTUend="TRUE" S_feature 2422724..2422921 /Source="Nicolas_S_feature" /locus_tag="new_2740896_2741093" /HighExp="BT, B36, S8, Lbstat, G/S, Pyr, Diami, S7, dia15, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1010" S_feature complement(2422913..2423184) /Source="Nicolas_S_feature" /locus_tag="new_2741085_2741356_c" /HighExp="Heat, BMM, Etha, S2, S3, S4, B36, S5, B60, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40965600000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1011" downshifts complement(2422955) /Source="Nicolas_upshifts" /id="D1373" /incds=0 /nref=37 /ntot=78 /MaxReadThrough="2.30607" /MaxDrop="6.9537" /score="19.9821634" /energy="-15.5" /TU="NA" /idTUdmin="U2066" /TUdmin=0 /isTUend="TRUE" CDS complement(2422961..2423122) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513986.1" /translation="MGKKLIETIQYPPYYCDVAYLESSHMKSRRNLFQNKKSLDVWQW ITLEIYWLI*" gene complement(2422961..2423122) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" CDS complement(2423185..2423940) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /function="16.14: Store" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 24128931; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein buffering protein for Zn2+ transport" /protein_id="NP_390560.1" /db_xref="EnsemblGenomes-Gn:BSU26830" /db_xref="EnsemblGenomes-Tr:CAB14624" /db_xref="GOA:O05410" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015304" /db_xref="SubtiList:BG12308" /db_xref="UniProtKB/Swiss-Prot:O05410" /translation="MNILFSKRLGILTIGSLLVLAGCQTSGSSAGESNQTTSSSAVEE DSSKTQEQTSDSHTHEHSHDHSHAHDEETEKIYEGYFKNSQVKDRLLSDWEGDWQSVY PYLQDGTLDEVFSYKSEHEGGKTAEEYKEYYKKGYQTDVDRIVIQKDTVTFFKNGKEY SGKYTYDGYEILTYDAGNRGVRYIFKLAKKAEGLPQYIQFSDHSIYPTKASHYHLYWG DDREALLDEVKNWPTYYPSKMDGHDIAHEMMAH*" gene complement(2423185..2423940) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" promotor_-10 complement(2423971..2423990) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2423987) /Source="Nicolas_upshifts" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" promotor_-35 complement(2424006..2424011) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2424072..2424602) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" gene complement(2424072..2424602) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" promotor_-10 complement(2424648..2424667) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2424671) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2424681..2424688) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2424737..2425717 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" gene 2424737..2425717 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" CDS complement(2425991..2427307) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" gene complement(2425991..2427307) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" S_feature complement(2427308..2427421) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2427422..2428291) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" gene complement(2427422..2428291) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" promotor_-10 complement(2428314..2428333) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2428331) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" promotor_-35 complement(2428348..2428353) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2428398..2428399) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2428406) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" promotor_-35 complement(2428436..2428437) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2428436..2429539 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" gene 2428436..2429539 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" misc_feature 2429429..2429448 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2429435 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(2429786) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" CDS complement(2429812..2430645) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" gene complement(2429812..2430645) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" misc_feature complement(2430675..2430694) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2430684) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" promotor_-35 2430850..2430854 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2430865..2431087 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2430865 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" promotor_-10 2430869..2430888 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2431088..2431351 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" gene 2431088..2431351 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" downshifts 2431339 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" CDS 2431488..2432303 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" gene 2431488..2432303 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" S_feature complement(2432638..2432710) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2432681) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" CDS complement(2432711..2433067) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" gene complement(2432711..2433067) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" CDS complement(2433120..2433479) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" gene complement(2433120..2433479) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" misc_feature complement(2433572..2433591) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2433582) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" CDS complement(2433751..2433852) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" gene complement(2433751..2433852) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" S_feature complement(2433892..2433994) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2433934) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" CDS complement(2433995..2434381) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" gene complement(2433995..2434381) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" misc_feature complement(2434423..2434439) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2434439) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" promotor_-35 2434572..2434578 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2434593..2434604 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2434593 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" CDS 2434630..2434875 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" gene 2434630..2434875 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" CDS 2434893..2435261 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" gene 2434893..2435261 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" CDS 2435280..2436416 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" gene 2435280..2436416 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" CDS 2436435..2436632 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" gene 2436435..2436632 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" CDS 2436648..2436947 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" gene 2436648..2436947 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" downshifts 2436938 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" CDS complement(2437210..2437632) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" gene complement(2437210..2437632) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" promotor_-35 2437630..2437633 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2437649..2437668 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2437664..2437814 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2437664 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" promotor_-10 complement(2437667..2437686) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2437674) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" promotor_-35 complement(2437700..2437707) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2437783..2437802) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2437791) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" CDS 2437815..2438009 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" gene 2437815..2438009 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" promotor_-35 complement(2437817..2437824) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2438027..2438034 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2438050..2438069 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2438054 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" S_feature 2438055..2438139 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2438140..2439189 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" gene 2438140..2439189 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" promotor_-35 2439257..2439264 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2439279..2439298 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2439292 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" CDS 2439320..2439829 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" gene 2439320..2439829 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" downshifts 2439798 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" S_feature 2439843..2440948 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2439871..2441904) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" gene complement(2439871..2441904) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" downshifts complement(2439896) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" CDS complement(2441813..2441980) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" gene complement(2441813..2441980) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" S_feature complement(2441905..2442060) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2442061..2442888) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " gene complement(2442061..2442888) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" CDS complement(2442909..2443718) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" gene complement(2442909..2443718) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" CDS complement(2443735..2444223) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" gene complement(2443735..2444223) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" CDS complement(2444223..2444663) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" gene complement(2444223..2444663) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" downshifts 2444660 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" misc_feature complement(2444700..2444718) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2444704) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" CDS complement(2444853..2447660) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" gene complement(2444853..2447660) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" misc_feature complement(2447876..2447895) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2447882) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" CDS 2448207..2448347 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" gene 2448207..2448347 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" misc_feature 2448328..2448347 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2448338 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" CDS 2448386..2449774 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" gene 2448386..2449774 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" downshifts 2449763 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" S_feature complement(2449796..2449869) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2449838) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" CDS complement(2449870..2450502) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" gene complement(2449870..2450502) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" downshifts complement(2449926) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(2450556..2450575) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450567) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" promotor_-35 2450581..2450587 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2450590..2450597) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2450601..2450620 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2450606 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" CDS 2450655..2451482 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " gene 2450655..2451482 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" downshifts 2451478 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" promotor_-35 2451595..2451604 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2451617..2451632 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2451622 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" CDS 2451678..2452178 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" gene 2451678..2452178 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" CDS 2452178..2453035 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" gene 2452178..2453035 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" promotor_-10 complement(2453053..2453064) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2453072) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2453079..2453085) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2453146..2455050 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" gene 2453146..2455050 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" promotor_-35 2455131..2455137 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2455153..2455171 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2455159 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" CDS 2455184..2455474 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" gene 2455184..2455474 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" S_feature 2455475..2455590 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2455572..2455579 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2455592..2455717 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2455592 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" promotor_-10 2455593..2455611 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2455611..2455711 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" gene 2455611..2455711 /gene="surF" /locus_tag="BSU_misc_RNA_82" downshifts 2455674 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" CDS complement(2455718..2458882) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" gene complement(2455718..2458882) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" downshifts complement(2455734) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" promotor_-35 2456868..2456877 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2456891..2456910 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2456912 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2458898..2459482) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" gene complement(2458898..2459482) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" CDS complement(2459705..2460247) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" gene complement(2459705..2460247) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" S_feature complement(2460248..2460333) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2460331..2460346) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2460333) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" promotor_-35 complement(2460359..2460368) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2460402..2460618) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2460436..2460594) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" gene complement(2460436..2460594) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" downshifts complement(2460445) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" promotor_-10 complement(2460616..2460635) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2460618) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" S_feature complement(2460620..2460750) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2460649..2460658) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2460751..2460900) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" gene complement(2460751..2460900) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" downshifts 2460894 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" S_feature complement(2460901..2460991) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2460993..2461212) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2461036) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" downshifts 2461158 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" promotor_-10 complement(2461191..2461210) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461212) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" S_feature complement(2461214..2461289) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2461225..2461232) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2461290..2462090) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" gene complement(2461290..2462090) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" S_feature complement(2462159..2462312) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2462202) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" promotor_-10 complement(2462303..2462322) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2462312) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" promotor_-35 complement(2462337..2462343) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2462353..2462721) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" gene complement(2462353..2462721) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" S_feature complement(2462722..2462818) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2462804..2462823) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2462808..2462811 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2462824) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" promotor_-10 2462827..2462846 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2462829 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" S_feature 2462830..2463036 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2462839..2462843) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2463037..2465979 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" gene 2463037..2465979 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" CDS 2465998..2466480 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" gene 2465998..2466480 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" downshifts 2466460 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" CDS complement(2466516..2466746) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" gene complement(2466516..2466746) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" downshifts complement(2466536) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" S_feature complement(2466747..2466828) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2466829..2467968) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" gene complement(2466829..2467968) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" CDS complement(2467970..2468893) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" gene complement(2467970..2468893) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" downshifts complement(2468886) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" S_feature complement(2468894..2468957) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2468958..2469653) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" gene complement(2468958..2469653) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" promotor_-10 complement(2469393..2469412) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2469411) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-35 complement(2469425..2469434) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2469674..2470315) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" gene complement(2469674..2470315) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" promotor_-10 complement(2469882..2469901) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2469901) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-35 complement(2469918..2469921) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2470367..2470376 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2470373..2470392) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2470379) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-10 2470389..2470408 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2470398..2470462 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2470398 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" promotor_-35 complement(2470408..2470411) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2470443..2470450 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2470464 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" promotor_-10 2470466..2470483 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2470508..2470711 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" gene 2470508..2470711 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" downshifts 2470718 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" CDS complement(2470748..2471449) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" gene complement(2470748..2471449) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" downshifts complement(2470760) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" CDS complement(2471514..2473268) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" gene complement(2471514..2473268) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" misc_feature complement(2471542..2471561) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2471552) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-10 complement(2472583..2472598) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472586) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-35 complement(2472611..2472620) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2472814..2472832) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472828) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-35 2472847..2472854 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2472847..2472852) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2472869..2472888 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2472874 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2473322..2473795) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" gene complement(2473322..2473795) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" downshifts complement(2473329) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" S_feature complement(2473796..2473928) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2473910..2473929) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2473928) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" S_feature complement(2473930..2474038) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2473943..2473950) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2474031..2474050) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474038) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" CDS complement(2474046..2474681) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" gene complement(2474046..2474681) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" promotor_-35 complement(2474066..2474070) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2474176..2474181 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2474197..2474215 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2474204 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2474688..2475956) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" gene complement(2474688..2475956) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" CDS complement(2475975..2476904) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" gene complement(2475975..2476904) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" CDS complement(2476910..2477563) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " gene complement(2476910..2477563) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" S_feature complement(2477564..2477668) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2477650..2477669) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2477668) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" promotor_-35 complement(2477685..2477689) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2477715..2478797) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" gene complement(2477715..2478797) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" downshifts complement(2477749) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" promotor_-10 complement(2478813..2478832) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2478833) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" promotor_-35 complement(2478847..2478850) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2478923) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" CDS complement(2478928..2479209) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" gene complement(2478928..2479209) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" downshifts complement(2478988) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" CDS complement(2479227..2479643) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" gene complement(2479227..2479643) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" promotor_-10 complement(2479475..2479493) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479494) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2479509..2479514) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2479651..2479917) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" gene complement(2479651..2479917) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" promotor_-35 2479805..2479813 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2479828..2479847 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2479836..2481025 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2479836 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" S_feature complement(2479918..2479978) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2479972..2479991) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479978) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" CDS complement(2480002..2482638) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" gene complement(2480002..2482638) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" promotor_-35 complement(2480005..2480012) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2482404..2482422) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482420) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2482436..2482443) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2482639..2482717) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2482718..2482925) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2482718..2482925) /gene="tboA" /locus_tag="BSU_misc_RNA_40" promotor_-10 complement(2482933..2482952) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482948) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2482967..2482974) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2482969..2484030) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" gene complement(2482969..2484030) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" promotor_-35 2483939..2483944 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2483950..2484185 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2483951 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" promotor_-10 2483960..2483978 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2484047..2484058) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2484048) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" promotor_-35 complement(2484072..2484078) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2484186..2484914 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" gene 2484186..2484914 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" downshifts complement(2484642) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" CDS 2484936..2485757 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" gene 2484936..2485757 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" CDS 2485818..2486468 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" gene 2485818..2486468 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" CDS 2486485..2487141 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" gene 2486485..2487141 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" downshifts 2487140 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" CDS complement(2487176..2487307) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " gene complement(2487176..2487307) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" downshifts complement(2487194) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" CDS complement(2487329..2487520) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" gene complement(2487329..2487520) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" CDS complement(2487532..2488056) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" gene complement(2487532..2488056) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" upshifts complement(2487643) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" promotor_-10 complement(2487647..2487658) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2487673..2487679) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2488027..2488038) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488033) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" promotor_-35 complement(2488053..2488059) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2488114..2490510) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" gene complement(2488114..2490510) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" downshifts complement(2488140) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" promotor_-35 2488360..2488366 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2488374 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" promotor_-10 2488381..2488392 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2488394..2488743 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2488495) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" CDS complement(2490535..2491155) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" gene complement(2490535..2491155) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" CDS complement(2491241..2492356) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" gene complement(2491241..2492356) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" downshifts complement(2491242) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" CDS complement(2492387..2493526) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" gene complement(2492387..2493526) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" promotor_-10 complement(2493093..2493112) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2493105) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" promotor_-35 complement(2493126..2493133) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2493545..2493961) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" gene complement(2493545..2493961) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" S_feature complement(2493962..2494059) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2494044..2494063) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2494059) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" promotor_-35 complement(2494079..2494082) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2494107..2494114 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2494128..2494147 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2494136 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" CDS 2494164..2495429 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" gene 2494164..2495429 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" downshifts 2495428 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" CDS complement(2495471..2496235) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" gene complement(2495471..2496235) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" downshifts complement(2495489) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2496319..2496519) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" gene complement(2496319..2496519) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" downshifts complement(2496337) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" upshifts 2496506 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2496507..2496516 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2496517..2496536) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2496528) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" promotor_-35 complement(2496549..2496556) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2496571..2498349) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" gene complement(2496571..2498349) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" CDS complement(2498363..2499637) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" gene complement(2498363..2499637) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" misc_RNA complement(2499727..2499959) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" gene complement(2499727..2499959) /gene="tboH" /locus_tag="BSU_misc_RNA_42" downshifts complement(2499757) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" promotor_-35 2499969..2499972 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2499983..2500002) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2499987..2500006 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2499989..2500273 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2499989 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" upshifts complement(2500002) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" promotor_-35 complement(2500017..2500024) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2500019..2500189) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" gene complement(2500019..2500189) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" promotor_-10 complement(2500220..2500231) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2500237) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" promotor_-35 complement(2500246..2500252) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2500249..2500256 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2500270..2500288 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2500275 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" CDS 2500322..2501878 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" gene 2500322..2501878 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" downshifts 2501857 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" CDS complement(2501905..2502303) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" gene complement(2501905..2502303) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" downshifts complement(2501913) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" CDS complement(2502357..2504561) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" gene complement(2502357..2504561) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" promotor_-10 complement(2504590..2504609) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2504597) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" S_feature complement(2504599..2504689) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2504624..2504631) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2504653 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" CDS complement(2504729..2505241) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" gene complement(2504729..2505241) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" downshifts complement(2504734) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" CDS complement(2505247..2507607) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" gene complement(2505247..2507607) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" promotor_-10 complement(2505711..2505730) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2505719) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" promotor_-35 complement(2505744..2505753) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2507621..2507640) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507632) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" promotor_-35 complement(2507655..2507661) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2507674..2507997) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" gene complement(2507674..2507997) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" promotor_-10 complement(2508018..2508036) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2508029) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" promotor_-35 complement(2508051..2508057) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2508073..2508570) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" gene complement(2508073..2508570) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" S_feature complement(2508571..2508646) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2508640..2508659) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2508646) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" promotor_-35 complement(2508673..2508680) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2508728..2510941) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" gene complement(2508728..2510941) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" downshifts complement(2508733) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" promotor_-35 2510500..2510505 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2510519..2510538 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2510527 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2510980..2511276) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" gene complement(2510980..2511276) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" downshifts 2511187 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" S_feature complement(2511277..2511355) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2511317..2511322 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2511339..2511357 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2511341..2511360) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2511341 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" upshifts complement(2511355) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" S_feature complement(2511357..2512275) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2511375..2511378) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2511392..2512948 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" gene 2511392..2512948 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" promotor_-10 complement(2512261..2512279) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2512275) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" promotor_-35 complement(2512291..2512299) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2512949..2513713 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2512952..2513608) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" gene complement(2512952..2513608) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" promotor_-10 complement(2513627..2513638) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2513639) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" promotor_-35 complement(2513652..2513658) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2513691..2513696 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2513712..2513730 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2513715 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" CDS 2513743..2514195 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" gene 2513743..2514195 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" downshifts 2514179 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" downshifts complement(2514234) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" CDS complement(2514252..2514518) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" gene complement(2514252..2514518) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" CDS complement(2514555..2515700) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" gene complement(2514555..2515700) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" upshifts complement(2514607) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" misc_feature complement(2514610) /Source="Nicolas_upshift_promotors" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2514651) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" promotor_-10 complement(2514653..2514672) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2514687..2514692) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2515727..2516755) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" gene complement(2515727..2516755) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" CDS complement(2516785..2516985) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" gene complement(2516785..2516985) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" CDS complement(2516978..2517982) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" gene complement(2516978..2517982) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" CDS complement(2517993..2518598) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" gene complement(2517993..2518598) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" promotor_-10 complement(2518617..2518636) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2518633) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" S_feature complement(2518635..2518736) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2518647..2518653) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2518737..2519249) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" gene complement(2518737..2519249) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" promotor_-10 complement(2519278..2519289) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2519293) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" CDS complement(2519297..2520604) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" gene complement(2519297..2520604) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" promotor_-35 complement(2519304..2519310) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2520558) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" promotor_-10 complement(2520628..2520646) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2520643) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" promotor_-35 complement(2520661..2520667) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2520675..2521700) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" gene complement(2520675..2521700) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" promotor_-10 complement(2521737..2521756) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2521757) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" promotor_-35 complement(2521771..2521778) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2521826..2521833 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2521847..2521866 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2521855 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" promotor_-35 2521887..2521892 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2521901 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" promotor_-10 2521908..2521926 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2521938..2522585 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" gene 2521938..2522585 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" S_feature complement(2522260..2522593) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2522564 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" S_feature complement(2522595..2522792) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2522631..2522753) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" gene complement(2522631..2522753) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" downshifts complement(2522638) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" upshifts complement(2522801) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" promotor_-10 complement(2522802..2522819) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2522826..2522833) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2522838..2523128 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" gene 2522838..2523128 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" misc_feature 2522849..2522868 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2522849..2522996 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2522849 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" CDS 2523135..2523275 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" gene 2523135..2523275 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" downshifts 2523264 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2523324..2523330 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2523338..2523438 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2523345..2523363 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2523346 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" upshifts 2523398 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" CDS 2523439..2524893 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" gene 2523439..2524893 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" downshifts 2524894 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" CDS complement(2524934..2525656) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" gene complement(2524934..2525656) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" S_feature 2524939..2525360 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2524950) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" promotor_-10 complement(2525679..2525698) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2525696) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" promotor_-35 complement(2525712..2525719) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2525759..2526355) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" gene complement(2525759..2526355) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" downshifts complement(2525774) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" promotor_-10 complement(2526398..2526409) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2526400) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" S_feature complement(2526402..2526466) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2526424..2526430) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2526503..2527666) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" gene complement(2526503..2527666) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" downshifts complement(2526511) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" S_feature complement(2527667..2527742) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2527718..2527736) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2527742) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2527752..2527757) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2527783..2528889) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" gene complement(2527783..2528889) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" promotor_-10 complement(2528465..2528483) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2528490) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2528499..2528504) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2528801 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2528802..2528805 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2528876..2529745) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" gene complement(2528876..2529745) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" downshifts 2528970 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" CDS complement(2529699..2531294) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" gene complement(2529699..2531294) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" promotor_-10 complement(2531322..2531341) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2531322..2531329 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2531343 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" promotor_-10 2531345..2531364 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2531346) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2531356..2531363) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2531397..2532584 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" gene 2531397..2532584 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" promotor_-10 complement(2531398..2531417) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2531416) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2531432..2531441) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2532299..2532304 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2532313 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" promotor_-10 2532315..2532334 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2532544..2533086 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" gene 2532544..2533086 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" downshifts 2533069 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" CDS complement(2533111..2533968) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" gene complement(2533111..2533968) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" S_feature 2533114..2533823 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2533131) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" CDS complement(2533985..2534428) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" gene complement(2533985..2534428) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" CDS complement(2534489..2535775) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" gene complement(2534489..2535775) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" CDS complement(2535809..2536387) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" gene complement(2535809..2536387) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" S_feature complement(2536388..2536453) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2536438..2536457) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2536453) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" S_feature complement(2536455..2536672) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2536465..2536587 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" gene 2536465..2536587 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" promotor_-35 complement(2536471..2536478) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2536708..2536992) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" gene complement(2536708..2536992) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" downshifts complement(2536717) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" CDS complement(2537005..2537343) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" gene complement(2537005..2537343) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" CDS complement(2537346..2537654) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" gene complement(2537346..2537654) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" misc_RNA complement(2537668..2537743) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" gene complement(2537668..2537743) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" promotor_-10 complement(2537755..2537774) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537775) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" promotor_-35 complement(2537788..2537795) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2537801..2538667) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" gene complement(2537801..2538667) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" CDS complement(2538660..2539454) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" gene complement(2538660..2539454) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" downshifts 2539457 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" promotor_no_box 2539463..2539563 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2539478..2539496) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2539489) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" promotor_-35 complement(2539512..2539517) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2539523 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2539566 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" downshifts complement(2539601) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" CDS complement(2539604..2540410) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" gene complement(2539604..2540410) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" CDS complement(2540412..2541092) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" gene complement(2540412..2541092) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" CDS complement(2541145..2541663) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" gene complement(2541145..2541663) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" CDS complement(2541660..2542532) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" gene complement(2541660..2542532) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" CDS complement(2542563..2543576) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" gene complement(2542563..2543576) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" upshifts complement(2543617) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" misc_feature complement(2543629..2543647) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2543668..2544363) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" gene complement(2543668..2544363) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" CDS complement(2544400..2544969) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" gene complement(2544400..2544969) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" promotor_-10 complement(2544821..2544836) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2544830) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" promotor_-35 complement(2544849..2544858) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2545008..2545027) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2545024) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" promotor_-35 complement(2545041..2545047) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2545120) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" CDS complement(2545122..2546120) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" gene complement(2545122..2546120) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" promotor_-10 complement(2546167..2546186) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2546175) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" promotor_-35 complement(2546198..2546205) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2546243) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" CDS complement(2546254..2547000) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" gene complement(2546254..2547000) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" promotor_-10 complement(2547028..2547047) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2547035) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" promotor_-35 complement(2547062..2547069) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2547140..2548432) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" gene complement(2547140..2548432) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" downshifts complement(2547145) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" S_feature complement(2548433..2548491) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2548492..2551134) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" gene complement(2548492..2551134) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" S_feature complement(2551135..2551193) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2551194..2551416) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2551194..2551416) /gene="tboV" /locus_tag="BSU_misc_RNA_44" downshifts complement(2551237) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" promotor_-10 complement(2551445..2551464) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2551457) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" S_feature complement(2551459..2551567) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2551479..2551484) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2551521..2551530 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2551543..2551562 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2551544 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" promotor_-10 complement(2551560..2551574) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2551567) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" promotor_-35 complement(2551582..2551586) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2551582..2551773 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" gene 2551582..2551773 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" CDS complement(2551792..2552817) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" gene complement(2551792..2552817) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" downshifts complement(2551822) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" CDS complement(2552850..2554577) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" gene complement(2552850..2554577) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" promotor_-35 2554179..2554182 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2554198..2554217 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2554204 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2554573..2554577 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2554586..2554600 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2554600 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2554615..2554633) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2554631) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" promotor_-35 complement(2554649..2554654) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2554708..2556000) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" gene complement(2554708..2556000) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" downshifts complement(2554725) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" CDS complement(2556030..2557004) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" gene complement(2556030..2557004) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" CDS complement(2557001..2557789) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" gene complement(2557001..2557789) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" CDS complement(2557779..2558723) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" gene complement(2557779..2558723) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" CDS complement(2558756..2559586) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" gene complement(2558756..2559586) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" CDS complement(2559594..2560961) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" gene complement(2559594..2560961) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" misc_feature complement(2561025..2561044) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2561031) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" S_feature complement(2561033..2561122) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2561082..2561101 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2561090 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2561119..2561138) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2561122) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" S_feature complement(2561124..2561540) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2561149..2561157) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2561191..2561688 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" gene 2561191..2561688 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" promotor_-10 complement(2561524..2561542) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2561540) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" S_feature complement(2561542..2561672) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2561558..2561564) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2561652..2561663) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2561672) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" promotor_-35 complement(2561678..2561684) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2561710..2562297) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" gene complement(2561710..2562297) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" downshifts complement(2561738) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" CDS complement(2562294..2564618) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" gene complement(2562294..2564618) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" S_feature complement(2564619..2564730) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2564715..2564734) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2564730) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" promotor_-35 complement(2564748..2564755) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2564799..2566457) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" gene complement(2564799..2566457) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" downshifts complement(2564818) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2566501..2566519) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2566512) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" promotor_-35 complement(2566535..2566540) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2566609..2567871) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" gene complement(2566609..2567871) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" downshifts complement(2566619) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" S_feature complement(2567872..2567961) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2567949..2567968) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2567961) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" S_feature complement(2567963..2568094) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2567980..2567987) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2568139) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" CDS complement(2568143..2569417) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" gene complement(2568143..2569417) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" S_feature complement(2569418..2569607) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2569594..2569613) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2569607) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" promotor_-35 complement(2569628..2569632) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2569645..2570649) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" gene complement(2569645..2570649) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" promotor_-10 complement(2570674..2570693) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2570692) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" promotor_-35 complement(2570705..2570712) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2570768..2571367) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" gene complement(2570768..2571367) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" downshifts complement(2570789) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" CDS complement(2571380..2572798) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" gene complement(2571380..2572798) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" promotor_-35 2572687..2572691 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2572706..2572710 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2572706 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2572848..2573945) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" gene complement(2572848..2573945) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" CDS complement(2573966..2575522) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" gene complement(2573966..2575522) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" promotor_-35 2574362..2574365 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2574378..2576819 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2574378 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" promotor_-10 2574380..2574399 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2575509..2576537) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" gene complement(2575509..2576537) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" CDS complement(2576561..2577079) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" gene complement(2576561..2577079) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" promotor_-35 2576800..2576803 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2576819..2576823 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2576821 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2577076..2578800) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" gene complement(2577076..2578800) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" S_feature complement(2578801..2578921) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2578922..2579168) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2578922..2579168) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" downshifts complement(2578965) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" S_feature complement(2579169..2579295) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2579277..2579296) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2579295) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" S_feature complement(2579297..2579427) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2579311..2579318) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2579422..2579441) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2579431) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" promotor_-35 complement(2579455..2579458) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2579553..2579562 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2579576..2579595 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2579578 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" CDS 2579616..2579951 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" gene 2579616..2579951 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" downshifts 2579945 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" promotor_-35 2580032..2580039 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2580053..2580072 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2580055..2580119 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2580055 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" CDS 2580120..2580575 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" gene 2580120..2580575 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" promotor_-35 2580683..2580689 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2580703..2580721 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2580710 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" CDS 2580759..2581580 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" gene 2580759..2581580 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" downshifts 2581573 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" downshifts 2581637 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" tRNA complement(2581644..2581717) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2581644..2581717) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" downshifts complement(2581678) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" promotor_-10 complement(2581754..2581773) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2581757) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" promotor_-35 complement(2581787..2581794) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2581848..2582357) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" gene complement(2581848..2582357) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" downshifts complement(2581865) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" CDS complement(2582373..2582969) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" gene complement(2582373..2582969) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" CDS complement(2582982..2583719) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" gene complement(2582982..2583719) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" promotor_-10 complement(2583801..2583820) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2583817) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" CDS complement(2583830..2584930) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" gene complement(2583830..2584930) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" promotor_-35 complement(2583835..2583840) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2583847) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" promotor_-10 complement(2584953..2584971) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2584969) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" promotor_-35 complement(2584986..2584991) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2585045..2585863) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" gene complement(2585045..2585863) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" downshifts complement(2585057) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" CDS complement(2585871..2586311) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" gene complement(2585871..2586311) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" promotor_-10 complement(2586354..2586373) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2586363) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" S_feature complement(2586365..2586507) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2586389..2586393) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2586552) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" CDS complement(2586555..2586779) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" gene complement(2586555..2586779) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" upshifts 2586828 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2586830..2586848 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2586837..2586856) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2586857) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" promotor_-35 complement(2586870..2586879) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2586895..2587338) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" gene complement(2586895..2587338) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" CDS complement(2587399..2588160) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" gene complement(2587399..2588160) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" downshifts complement(2587407) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" CDS complement(2588163..2589923) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" gene complement(2588163..2589923) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" CDS complement(2589957..2590565) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" gene complement(2589957..2590565) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" promotor_-35 2590335..2590342 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2590355..2590374 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2590357 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2590566..2590661) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2590651..2590670) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2590661) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" S_feature complement(2590663..2591284) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2590685..2590692) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2590800..2590804 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2590814..2590914 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2590821..2590840 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2590830 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" CDS 2590858..2591304 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" gene 2590858..2591304 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" upshifts 2590874 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" downshifts 2591292 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" downshifts complement(2591330) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" CDS complement(2591348..2592574) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" CDS complement(2591348..2591839) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" gene complement(2591348..2592574) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" gene complement(2591348..2591839) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" downshifts complement(2592688) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" misc_RNA complement(2592700..2592879) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" gene complement(2592700..2592879) /gene="kswC" /locus_tag="BSU_misc_RNA_46" downshifts complement(2592732) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2592904..2592923) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2592911) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" promotor_-35 complement(2592936..2592943) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2592944..2594716) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" gene complement(2592944..2594716) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" promotor_-10 complement(2594743..2594762) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2594757) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" promotor_-35 complement(2594776..2594783) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2594846) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" CDS complement(2594852..2595166) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" gene complement(2594852..2595166) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" promotor_-10 complement(2595192..2595211) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2595206) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" S_feature complement(2595208..2595417) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2595227..2595229) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2595311..2595421) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" gene complement(2595311..2595421) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo promotor_-10 complement(2595407..2595425) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2595417) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" promotor_-35 complement(2595440..2595446) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2595489..2596976) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" gene complement(2595489..2596976) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" S_feature complement(2596977..2597089) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2597070..2597089) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2597089) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" promotor_-35 complement(2597104..2597111) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2597193..2598170) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" gene complement(2597193..2598170) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" downshifts complement(2597201) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" CDS complement(2598206..2598979) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" gene complement(2598206..2598979) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" CDS complement(2598994..2599770) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" gene complement(2598994..2599770) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" downshifts 2599059 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" CDS complement(2599785..2600369) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" gene complement(2599785..2600369) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" promotor_-10 complement(2600411..2600430) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2600411) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" promotor_-35 complement(2600443..2600450) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2600474..2602156) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" gene complement(2600474..2602156) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" misc_feature complement(2602185..2602204) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2602193) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" downshifts complement(2602281) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" CDS complement(2602345..2602749) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" gene complement(2602345..2602749) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" downshifts complement(2602347) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" CDS complement(2602764..2605121) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" gene complement(2602764..2605121) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" CDS complement(2605142..2606854) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" gene complement(2605142..2606854) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" S_feature complement(2606855..2606927) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2606928..2607461) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" gene complement(2606928..2607461) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" CDS complement(2607468..2607725) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" gene complement(2607468..2607725) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" promotor_-10 complement(2607752..2607771) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2607768) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" promotor_-35 complement(2607783..2607790) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2607808..2607827 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2607815 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" CDS 2607859..2608800 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" gene 2607859..2608800 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" promotor_-10 complement(2608532..2608551) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2608547) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2608565..2608572) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2608783 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" downshifts complement(2608815) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" CDS complement(2608836..2611250) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" gene complement(2608836..2611250) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" downshifts complement(2608859) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" CDS complement(2611266..2612300) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" gene complement(2611266..2612300) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" S_feature complement(2612301..2612621) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2612382..2612588 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" gene 2612382..2612588 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" S_feature 2612611..2612875 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2612611 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" promotor_-10 complement(2612616..2612635) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2612618..2612632 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2612621) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" promotor_-35 complement(2612650..2612653) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2612655..2613401) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" gene complement(2612655..2613401) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" promotor_-10 complement(2613428..2613447) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2613434..2613440 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2613441) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" promotor_-10 2613454..2613465 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2613461..2613467) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2613468 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" CDS 2613520..2613735 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" gene 2613520..2613735 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" S_feature complement(2613717..2615129) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2613746..2613753 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2613769..2613788 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2613777 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" CDS 2613804..2614910 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" gene 2613804..2614910 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" promotor_-35 2614946..2614949 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2614965..2614984 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2614969 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" CDS 2615013..2616425 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" gene 2615013..2616425 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" promotor_-10 complement(2615115..2615134) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2615129) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" promotor_-35 complement(2615147..2615156) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2616422..2617756 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" gene 2616422..2617756 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" downshifts 2617754 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" downshifts complement(2617793) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" CDS complement(2617795..2618037) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" gene complement(2617795..2618037) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" S_feature complement(2618038..2618209) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2618097..2618267) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" gene complement(2618097..2618267) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" CDS complement(2618210..2620006) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" gene complement(2618210..2620006) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" promotor_-10 complement(2618312..2618330) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2618330) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" promotor_-35 complement(2618342..2618350) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2620003 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" promotor_-10 complement(2620031..2620050) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2620041) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" promotor_-35 complement(2620065..2620071) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2620101..2620157) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2620125) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" CDS complement(2620158..2621660) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" gene complement(2620158..2621660) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" downshifts complement(2621531) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" promotor_no_box complement(2621635..2621735) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2621675) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" CDS complement(2621679..2622524) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" gene complement(2621679..2622524) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" CDS complement(2622525..2623466) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" gene complement(2622525..2623466) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" CDS complement(2623502..2624803) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" gene complement(2623502..2624803) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" CDS complement(2624834..2626018) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" gene complement(2624834..2626018) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" CDS complement(2626015..2626833) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" gene complement(2626015..2626833) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" CDS complement(2626811..2627500) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" gene complement(2626811..2627500) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" CDS complement(2627517..2629199) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" gene complement(2627517..2629199) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" CDS complement(2629213..2630703) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" gene complement(2629213..2630703) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" promotor_-10 complement(2630796..2630815) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2630803) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" S_feature complement(2630805..2630880) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2630830..2630837) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2630881..2631852) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" gene complement(2630881..2631852) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" S_feature complement(2631853..2631981) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2631966..2631985) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2631981) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" promotor_-35 complement(2632000..2632003) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2632049..2633134) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" gene complement(2632049..2633134) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" downshifts complement(2632063) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(2633160..2633179) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2633183) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" promotor_-35 complement(2633194..2633201) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2633252..2633261 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2633267 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" promotor_-10 2633273..2633288 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2633318..2633710 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" gene 2633318..2633710 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" downshifts 2633681 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" S_feature 2633726..2634032 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2633726..2633995) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" gene complement(2633726..2633995) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" downshifts complement(2633742) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" downshifts complement(2633911) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" downshifts 2633989 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" CDS complement(2634052..2634411) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" gene complement(2634052..2634411) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" downshifts complement(2634065) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" CDS complement(2634443..2634643) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" gene complement(2634443..2634643) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" CDS complement(2634656..2635177) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" gene complement(2634656..2635177) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" misc_RNA complement(2635239..2635378) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" gene complement(2635239..2635378) /locus_tag="BSU_misc_RNA_47" promotor_-10 complement(2635375..2635394) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2635385) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" S_feature complement(2635387..2635451) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2635408..2635415) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2635433..2635452) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2635451) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" promotor_-35 complement(2635468..2635472) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2635570..2635577 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2635591..2635609 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2635591 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" CDS 2635623..2636288 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" gene 2635623..2636288 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" downshifts 2636266 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" CDS complement(2636320..2637015) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" gene complement(2636320..2637015) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" downshifts complement(2636342) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" downshifts complement(2636386) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" CDS complement(2637037..2637477) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" gene complement(2637037..2637477) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" promotor_-10 complement(2637499..2637518) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2637518) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" promotor_-35 complement(2637534..2637537) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2637611..2638336) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" gene complement(2637611..2638336) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" downshifts complement(2637640) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" CDS complement(2638314..2640095) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" gene complement(2638314..2640095) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" promotor_-35 2640179..2640182 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2640191..2640210) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2640196) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2640197..2640216 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2640204 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" CDS 2640262..2641044 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" gene 2640262..2641044 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" downshifts 2641028 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" downshifts complement(2641078) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" CDS complement(2641085..2643016) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" gene complement(2641085..2643016) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" misc_RNA complement(2643060..2643307) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2643060..2643307) /gene="tboT" /locus_tag="BSU_misc_RNA_48" promotor_-10 complement(2643063..2643072) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643063) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" promotor_-35 complement(2643091) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2643118) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" promotor_-10 complement(2643318..2643337) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643331) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" S_feature complement(2643333..2643413) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2643353..2643357) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2643414..2644259) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" gene complement(2643414..2644259) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" promotor_-10 complement(2644279..2644297) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2644285) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2644313..2644318) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2644338..2644979) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" gene complement(2644338..2644979) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" CDS complement(2645013..2645948) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" gene complement(2645013..2645948) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" CDS complement(2645976..2647394) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" gene complement(2645976..2647394) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" promotor_-10 complement(2647423..2647442) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647431) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2647457..2647460) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2647509..2647967) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" gene complement(2647509..2647967) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" downshifts complement(2647528) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" S_feature complement(2647968..2648115) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2648106..2648125) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2648115) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" S_feature complement(2648117..2648195) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2648140..2648143) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2648240) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" CDS complement(2648241..2648621) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" gene complement(2648241..2648621) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" S_feature complement(2648622..2648776) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2648756..2648775) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2648763 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2648764..2648783 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2648776) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2648790..2648796) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2648854..2648865) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2648860..2649882) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" gene complement(2648860..2649882) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" upshifts complement(2648861) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" promotor_-35 complement(2648880..2648886) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2649926..2649945) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2649957) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" promotor_-35 complement(2649958..2649965) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2650088..2650468) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" gene complement(2650088..2650468) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" downshifts complement(2650112) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" S_feature complement(2650469..2650599) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2650524..2650528 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2650544..2650563 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2650545..2650651 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2650545 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" promotor_-10 complement(2650589..2650608) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650599) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" promotor_-35 complement(2650623..2650630) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2650652..2651842 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" gene 2650652..2651842 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" promotor_-10 complement(2651474..2651492) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2651490) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2651508..2651513) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2651866..2652708 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" gene 2651866..2652708 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" promotor_-35 2652481..2652486 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2652502..2652520 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2652503 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2652701 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" downshifts complement(2652741) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" CDS complement(2652750..2653343) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" gene complement(2652750..2653343) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" CDS complement(2653359..2653991) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" gene complement(2653359..2653991) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" S_feature complement(2653992..2654156) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2654157..2654987) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" gene complement(2654157..2654987) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" CDS complement(2655010..2657652) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" gene complement(2655010..2657652) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" promotor_-10 complement(2657707..2657726) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2657716) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" promotor_-35 complement(2657740..2657747) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2657776..2657895) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2657819) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" CDS complement(2657896..2659635) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" gene complement(2657896..2659635) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" CDS complement(2659628..2660350) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" gene complement(2659628..2660350) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" promotor_-10 complement(2660418..2660437) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2660428) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" S_feature complement(2660430..2660530) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2660451..2660457) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2660562..2661500) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" gene complement(2660562..2661500) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" downshifts complement(2660575) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" CDS complement(2661544..2662815) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" gene complement(2661544..2662815) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" misc_feature complement(2662600..2662619) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2662612) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" S_feature complement(2662816..2662898) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2662898) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" S_feature complement(2662900..2662978) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2662900..2662919) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2662935..2662939) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2662979..2664097) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" gene complement(2662979..2664097) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" downshifts 2663592 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" misc_feature 2663939..2663942 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2663947 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2664076 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" S_feature complement(2664098..2664304) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2664272..2664284 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2664283 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2664290..2664309) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2664304) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" promotor_-35 complement(2664324..2664328) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2664424) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" CDS complement(2664431..2664895) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" gene complement(2664431..2664895) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" promotor_-10 complement(2664908..2664927) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2664922) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" S_feature complement(2664924..2666109) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2664924..2664929 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2664940..2664948) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2664944..2664962 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2664950 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" CDS 2664992..2666107 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" gene 2664992..2666107 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" downshifts 2666078 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" CDS complement(2666140..2666523) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" gene complement(2666140..2666523) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" downshifts complement(2666154) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" S_feature complement(2666524..2666615) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2666616..2668373) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" gene complement(2666616..2668373) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" CDS complement(2668416..2669375) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" gene complement(2668416..2669375) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" S_feature complement(2669376..2669477) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2669466..2669485) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2669477) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" promotor_-35 complement(2669501..2669505) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2669559..2670536) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" gene complement(2669559..2670536) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" downshifts complement(2669586) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" CDS complement(2670521..2671393) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" gene complement(2670521..2671393) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" promotor_-35 2671355..2671360 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2671376..2671394 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2671380..2672554 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2671380 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" S_feature complement(2671394..2671477) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2671466..2671485) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2671477) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" S_feature complement(2671479..2671631) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2671501..2671505) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2671633..2671727) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2671676) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" CDS complement(2671728..2672960) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" gene complement(2671728..2672960) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" S_feature complement(2672961..2673077) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2673065..2673084) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2673077) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" CDS complement(2673097..2676444) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" gene complement(2673097..2676444) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" promotor_-35 complement(2673098..2673105) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2674109..2674118 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2674130..2674145 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2674130 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2674318..2674337) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2674337) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" promotor_-35 complement(2674351..2674358) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2676475..2676494) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2676493) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" promotor_-35 complement(2676508..2676515) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2676533..2676538 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2676550 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" promotor_-10 2676554..2676572 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2676584..2676925 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" gene 2676584..2676925 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" CDS 2676922..2677425 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" gene 2676922..2677425 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" promotor_-35 2677458..2677461 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2677476..2677495 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2677476 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" CDS 2677527..2677718 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" gene 2677527..2677718 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" downshifts complement(2677528) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" downshifts 2677694 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" CDS complement(2677736..2678677) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" gene complement(2677736..2678677) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" S_feature 2677739..2678110 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2677771) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2678079..2678088 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2678102..2678121 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2678112..2678506 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2678112 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" promotor_-35 2678468..2678474 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2678490..2678509 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2678508..2678807 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2678508 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" promotor_-10 complement(2678696..2678715) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2678712) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" S_feature complement(2678714..2679128) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2678730..2678733) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2678808..2679110 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" gene 2678808..2679110 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" S_feature 2679111..2680906 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2679129..2680448) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" gene complement(2679129..2680448) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" promotor_-10 complement(2680474..2680493) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2680495) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" promotor_-35 complement(2680508..2680513) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2680624..2681526) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" gene complement(2680624..2681526) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" CDS complement(2681545..2682795) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" gene complement(2681545..2682795) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" CDS complement(2682813..2683505) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" gene complement(2682813..2683505) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" CDS complement(2683552..2684880) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" gene complement(2683552..2684880) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" CDS complement(2684877..2685158) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" gene complement(2684877..2685158) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" CDS complement(2685173..2686177) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" gene complement(2685173..2686177) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" CDS complement(2686174..2686953) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" gene complement(2686174..2686953) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" CDS complement(2686950..2687657) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" gene complement(2686950..2687657) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" CDS complement(2687687..2688406) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" gene complement(2687687..2688406) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" promotor_-35 2688232..2688239 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2688254..2688273 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2688254 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2688428..2689240) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" gene complement(2688428..2689240) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" CDS complement(2689254..2690063) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" gene complement(2689254..2690063) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" CDS complement(2690077..2690613) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" gene complement(2690077..2690613) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" promotor_-35 2690650..2690657 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2690668..2690687) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2690671..2690690 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2690674..2690765 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2690674 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" upshifts complement(2690684) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" promotor_-35 complement(2690701..2690708) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2690766..2691692 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" gene 2690766..2691692 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" S_feature complement(2691168..2691697) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2691742) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" CDS complement(2691743..2692426) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" gene complement(2691743..2692426) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" S_feature complement(2692427..2692488) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2692489..2693256) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" gene complement(2692489..2693256) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" promotor_-10 complement(2693301..2693320) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2693323) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" promotor_-35 complement(2693336..2693338) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2693383..2693619) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" gene complement(2693383..2693619) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" downshifts 2693468 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" downshifts complement(2693488) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" CDS complement(2693579..2694964) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" gene complement(2693579..2694964) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" CDS complement(2694961..2696172) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" gene complement(2694961..2696172) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" S_feature complement(2696173..2696250) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2696243..2696262) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2696249) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" promotor_-35 complement(2696277..2696284) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2696342..2696854) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" gene complement(2696342..2696854) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" downshifts complement(2696360) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2696880..2696899) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2696888) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" promotor_-35 complement(2696913..2696920) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2696939..2698126) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" gene complement(2696939..2698126) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" downshifts complement(2696954) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" S_feature complement(2698127..2698231) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2698216..2698235) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2698231) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" S_feature complement(2698233..2698362) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2698251..2698255) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2698299..2698502) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" gene complement(2698299..2698502) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" promotor_-10 complement(2698360..2698371) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2698362) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" promotor_-35 complement(2698386..2698392) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2698474..2699463) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" gene complement(2698474..2699463) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" downshifts complement(2698492) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" CDS complement(2699524..2700027) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" gene complement(2699524..2700027) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" downshifts complement(2699530) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" promotor_no_box 2699744..2699844 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2699804 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2700023 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2700050..2700069) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2700066) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" promotor_-35 complement(2700083..2700090) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2700137..2700592) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" gene complement(2700137..2700592) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" downshifts complement(2700165) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" CDS complement(2700606..2701286) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" gene complement(2700606..2701286) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" upshifts complement(2700698) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" promotor_-10 complement(2700705..2700716) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2700731..2700737) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2701024) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(2701299..2701317) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2701313) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" promotor_-35 complement(2701332..2701337) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2701361..2701855) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" gene complement(2701361..2701855) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" downshifts complement(2701376) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" CDS complement(2701868..2702875) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" gene complement(2701868..2702875) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" promotor_-10 complement(2702899..2702914) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2702916) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" S_feature complement(2702918..2702997) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2702926..2702935) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2702975..2702994 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2702985 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" promotor_-10 complement(2702990..2703009) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2702994..2703060 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2702997) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" promotor_-35 complement(2703025..2703029) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2703061..2703864 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" gene 2703061..2703864 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" downshifts 2703794 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" downshifts 2703852 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" CDS complement(2703896..2705485) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" gene complement(2703896..2705485) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" downshifts complement(2703905) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" CDS complement(2705505..2707094) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" gene complement(2705505..2707094) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" promotor_-10 complement(2707140..2707157) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2707145) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" promotor_-35 complement(2707173..2707179) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2707272) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" CDS complement(2707273..2707482) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" gene complement(2707273..2707482) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" promotor_-35 2707478..2707482 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2707482 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2707491..2707505 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2707503..2707514) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2707514) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" promotor_-35 complement(2707529..2707535) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2707576..2708781) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" gene complement(2707576..2708781) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" CDS complement(2708785..2709930) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" gene complement(2708785..2709930) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" S_feature complement(2709931..2711074) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2710017..2710024 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2710035..2710124 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2710035 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" promotor_-10 2710037..2710056 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2710125..2711462 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" gene 2710125..2711462 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" promotor_-10 complement(2711060..2711079) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2711074) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" promotor_-35 complement(2711094..2711101) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2711438 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" CDS complement(2711557..2713245) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" gene complement(2711557..2713245) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" downshifts complement(2711558) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" S_feature complement(2713246..2713351) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2713328..2713336 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2713339..2713358) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2713347..2713366 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2713351) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" upshifts 2713351 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" S_feature 2713352..2713441 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2713353..2713912) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2713374..2713376) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2713442..2714248 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" gene 2713442..2714248 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" promotor_-10 complement(2713916..2713935) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2713929) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" promotor_-35 complement(2713947..2713954) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2714198..2714244) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2714220) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" CDS complement(2714245..2714868) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" gene complement(2714245..2714868) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" S_feature 2714249..2714591 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2714569..2714576 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2714591..2714610 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2714593..2714736 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2714593 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" promotor_-35 2714708..2714712 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2714728..2714747 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2714738..2714868 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2714738 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" S_feature 2714870..2714994 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2714870 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" promotor_-10 complement(2714884..2714902) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2714886..2714905 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2714902) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" promotor_-35 complement(2714913..2714921) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2714995..2715486 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" gene 2714995..2715486 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" downshifts 2715465 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" CDS complement(2715524..2717263) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" gene complement(2715524..2717263) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" downshifts complement(2715542) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" promotor_-35 2716737..2716744 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2716758..2716776 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2716761 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" S_feature 2716763..2717358 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2717293..2717312) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2717301) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" S_feature complement(2717303..2718136) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2717339..2717346 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2717360..2717557 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2717360..2717379 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2717360 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" misc_RNA 2717417..2717549 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" gene 2717417..2717549 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" CDS 2717558..2718160 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" gene 2717558..2718160 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" downshifts 2718083 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" S_feature complement(2718138..2718357) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2718146 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" downshifts complement(2718181) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" downshifts 2718193 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" S_feature 2718238..2718411 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2718353..2718371) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718365) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" downshifts 2718369 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(2718386..2718392) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2718431..2719699) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" gene complement(2718431..2719699) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" downshifts complement(2718457) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" misc_RNA complement(2719723..2719996) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" gene complement(2719723..2719996) /gene="tboY" /locus_tag="BSU_misc_RNA_83" S_feature complement(2719744..2719887) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2719787) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" promotor_-10 complement(2719994..2720013) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2720006) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" promotor_-35 complement(2720026..2720033) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2720041..2721759) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" gene complement(2720041..2721759) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" promotor_-35 2721773..2721780 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2721787..2721806) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2721795..2721814 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2721801 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2721810) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" promotor_-35 complement(2721820..2721826) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2721843..2721850 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2721864..2721883 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2721867 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" CDS 2721920..2722552 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" gene 2721920..2722552 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" promotor_-35 2722125..2722133 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2722147..2722166 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2722153 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" CDS 2722579..2723223 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" gene 2722579..2723223 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" CDS 2723220..2724383 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" gene 2723220..2724383 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" downshifts 2724374 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" CDS complement(2724394..2725122) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" gene complement(2724394..2725122) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" downshifts complement(2724430) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" CDS complement(2725112..2725930) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" gene complement(2725112..2725930) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" CDS complement(2725993..2726997) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" gene complement(2725993..2726997) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" downshifts complement(2726010) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" misc_feature complement(2727032..2727051) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2727047) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" S_feature complement(2727049..2727157) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2727157..2727176) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727157) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" S_feature complement(2727159..2727224) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2727190..2727196) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2727270) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" CDS complement(2727273..2728349) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" gene complement(2727273..2728349) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" promotor_-10 complement(2728390..2728409) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2728410) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" S_feature complement(2728412..2728512) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2728424..2728431) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2728446 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" promotor_-10 complement(2728500..2728519) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2728512) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" promotor_-35 complement(2728533..2728539) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2728585..2728911) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" gene complement(2728585..2728911) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" downshifts complement(2728594) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" CDS complement(2728935..2729390) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" gene complement(2728935..2729390) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" CDS complement(2729421..2729843) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" gene complement(2729421..2729843) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" promotor_-10 complement(2729864..2729882) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2729877) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" promotor_-35 complement(2729896..2729902) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2729916..2729934) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2729925) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" promotor_-35 complement(2729945..2729953) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2730005..2731303) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" gene complement(2730005..2731303) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" downshifts complement(2730014) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(2731328..2731347) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2731329) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" S_feature complement(2731331..2731527) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2731360..2731369) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2731510..2731529) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2731527) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" promotor_-35 complement(2731541..2731547) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2731553..2734411) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" gene complement(2731553..2734411) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" promotor_-10 complement(2734445..2734464) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2734455) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" promotor_-35 complement(2734480..2734484) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2734554) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" CDS complement(2734571..2735176) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" gene complement(2734571..2735176) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" CDS complement(2735192..2736001) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" gene complement(2735192..2736001) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" CDS complement(2736016..2736339) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" gene complement(2736016..2736339) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" S_feature complement(2736340..2736478) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2736378..2736494) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" gene complement(2736378..2736494) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" promotor_-10 complement(2736465..2736484) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2736478) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" promotor_-35 2736486..2736493 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2736500) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-35" promotor_-10 2736508..2736527 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2736513 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" CDS 2736574..2737020 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" gene 2736574..2737020 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" S_feature 2737021..2737749 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2737075..2738148) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" gene complement(2737075..2738148) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" downshifts complement(2737094) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2738170..2738189) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2738174) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" promotor_-35 complement(2738203..2738210) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2738245..2738248 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2738263..2738282 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2738268 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" CDS 2738307..2738624 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" gene 2738307..2738624 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" downshifts 2738624 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" CDS complement(2738677..2740377) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" gene complement(2738677..2740377) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" downshifts complement(2738696) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" promotor_-10 complement(2740409..2740427) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740416) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" promotor_-35 complement(2740442..2740448) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2740459..2741229) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" gene complement(2740459..2741229) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" S_feature complement(2741230..2741318) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2741316..2741335) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2741318) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" promotor_-35 complement(2741351..2741355) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2741375..2742016) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" gene complement(2741375..2742016) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" downshifts complement(2741385) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" downshifts complement(2741450) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(2742042..2742061) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2742051) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" S_feature complement(2742053..2742501) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2742077..2742081) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2742160..2742166 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2742181..2742192 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2742188 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" CDS 2742223..2742501 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" gene 2742223..2742501 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" S_feature 2742502..2742672 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2742502..2743116) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" gene complement(2742502..2743116) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" downshifts 2742650 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" S_feature complement(2743117..2743452) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2743444..2743463) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2743452) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" promotor_-35 complement(2743478..2743485) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2743479..2745635) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" gene complement(2743479..2745635) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" CDS complement(2745661..2746590) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" gene complement(2745661..2746590) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" CDS complement(2746639..2747553) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" gene complement(2746639..2747553) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" promotor_-10 complement(2747316..2747334) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2747324) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" promotor_-35 complement(2747348..2747354) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2747579..2748130) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" gene complement(2747579..2748130) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" misc_feature 2747993..2748012 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2747996 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2748153..2748172) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2748165) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" promotor_-35 complement(2748188..2748191) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2748213..2748220 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2748231..2748250 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2748234..2748245) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2748238 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" upshifts complement(2748248) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" promotor_-35 complement(2748259..2748265) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2748279..2749214 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" gene 2748279..2749214 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" downshifts 2749190 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" CDS complement(2749248..2750639) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" gene complement(2749248..2750639) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" downshifts complement(2749260) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" S_feature complement(2750640..2751080) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2750666..2750671 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2750685..2750704 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2750698 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" CDS 2750736..2752034 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" gene 2750736..2752034 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" promotor_-10 complement(2751057..2751076) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2751080) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" promotor_-35 complement(2751091..2751097) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2752021 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" CDS complement(2752074..2753231) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" gene complement(2752074..2753231) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" downshifts complement(2752099) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" promotor_-35 2752347..2752352 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752367..2752385 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2752375 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2753228..2753938) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" gene complement(2753228..2753938) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" promotor_-10 complement(2753952..2753967) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2753969) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" promotor_-35 complement(2753979..2753988) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2753995..2753996 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2754008..2754113 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2754008 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" promotor_-10 2754016..2754026 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2754079..2754085 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2754100..2754119 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2754115..2754228 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2754115 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" CDS 2754229..2754450 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" gene 2754229..2754450 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" downshifts 2754433 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" downshifts 2754502 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" CDS complement(2754571..2755290) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" gene complement(2754571..2755290) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" downshifts complement(2754585) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" downshifts complement(2755356) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" CDS complement(2755359..2756993) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" gene complement(2755359..2756993) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" misc_feature complement(2757025..2757044) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2757041) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" promotor_-35 2757111..2757115 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2757131..2757150 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2757149 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" CDS 2757195..2758457 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" gene 2757195..2758457 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" S_feature 2758458..2758556 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2758530..2758536 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2758552..2758570 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2758558..2758645 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2758558 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" CDS 2758646..2760184 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" gene 2758646..2760184 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" downshifts 2760164 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" CDS complement(2760221..2760403) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" gene complement(2760221..2760403) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" downshifts complement(2760240) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2760418..2760436) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2760438) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" promotor_-35 complement(2760452..2760457) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2760471..2761139) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" gene complement(2760471..2761139) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" CDS complement(2761161..2762447) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" gene complement(2761161..2762447) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" CDS complement(2762459..2762962) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" gene complement(2762459..2762962) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" CDS complement(2762959..2764080) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" gene complement(2762959..2764080) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" CDS complement(2764088..2765053) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" gene complement(2764088..2765053) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" upshifts complement(2765079) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" promotor_-10 complement(2765080..2765099) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2765114..2765121) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2765209..2765216 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2765229 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" promotor_-10 2765232..2765251 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2765269..2767587 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" gene 2765269..2767587 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" downshifts 2767577 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" CDS complement(2767628..2769124) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" gene complement(2767628..2769124) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" downshifts complement(2767630) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" CDS complement(2769149..2770009) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" gene complement(2769149..2770009) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" promotor_-10 complement(2770085..2770104) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2770094) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" promotor_-35 complement(2770120..2770127) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2770216..2770977) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" gene complement(2770216..2770977) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" downshifts complement(2770245) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" S_feature complement(2770978..2771053) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2771054..2772241) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" gene complement(2771054..2772241) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" CDS complement(2772310..2773317) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" gene complement(2772310..2773317) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" CDS complement(2773320..2774015) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" gene complement(2773320..2774015) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" CDS complement(2774012..2775181) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" gene complement(2774012..2775181) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" promotor_-35 2774048..2774055 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2774070..2774089 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2774088 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2775171..2776517) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" gene complement(2775171..2776517) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" promotor_-35 2775587..2775591 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2775606 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2775607..2775625 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2776507..2777283) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" gene complement(2776507..2777283) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" S_feature complement(2777284..2777376) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2777362..2777381) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2777376) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" promotor_-35 complement(2777396..2777403) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2777493..2778392) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" gene complement(2777493..2778392) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" promotor_-10 complement(2778415..2778433) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2778432) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2778444..2778452) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2778522..2778529 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2778545..2778564 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2778551 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" CDS 2778610..2779644 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" gene 2778610..2779644 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" promotor_-35 2779593..2779600 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2779615..2779623 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2779632 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" CDS 2779678..2780958 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" gene 2779678..2780958 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" CDS 2780951..2781862 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" gene 2780951..2781862 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" CDS 2781859..2782689 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" gene 2781859..2782689 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" promotor_-35 2782662..2782666 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2782682..2782701 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2782690 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2782709..2784007 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" gene 2782709..2784007 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" downshifts 2783988 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" CDS complement(2784029..2784340) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" gene complement(2784029..2784340) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" downshifts complement(2784040) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(2784364..2784383) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2784372) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" promotor_-35 complement(2784398..2784405) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2784406 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" CDS complement(2784457..2786871) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" gene complement(2784457..2786871) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" downshifts complement(2784461) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" S_feature complement(2786872..2786967) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2786981..2787195) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" gene complement(2786981..2787195) /gene="tboL" /locus_tag="BSU_misc_RNA_49" downshifts complement(2787012) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2787207..2787226) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2787228) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" promotor_-35 2787232..2787237 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2787241..2787246) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2787253..2787271 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2787266..2787706 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2787266 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" CDS complement(2787298..2787633) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" gene complement(2787298..2787633) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" S_feature complement(2787628..2787892) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2787877..2787896) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2787892) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" promotor_-35 complement(2787911..2787918) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2787931..2787938 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2787952..2787971 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2787968 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" S_feature 2787970..2788037 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2788038..2788823 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" gene 2788038..2788823 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" S_feature 2788824..2788880 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2789060..2790253) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" gene complement(2789060..2790253) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" downshifts complement(2789080) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" S_feature complement(2790254..2790352) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2790333..2790352) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2790352) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" promotor_-35 complement(2790366..2790373) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2790390..2790393 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2790408..2790427 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2790412 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" CDS 2790442..2791188 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" gene 2790442..2791188 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" downshifts 2791083 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" downshifts 2791182 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" CDS complement(2791225..2793165) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" gene complement(2791225..2793165) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" downshifts complement(2791236) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" CDS complement(2793155..2793916) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" gene complement(2793155..2793916) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" misc_feature complement(2793940..2793958) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2793959) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" CDS complement(2794018..2795022) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" gene complement(2794018..2795022) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" downshifts complement(2794057) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" CDS complement(2795015..2795710) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" gene complement(2795015..2795710) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" promotor_-10 complement(2795734..2795752) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2795746) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" promotor_-35 complement(2795768..2795771) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2795807..2797117) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" gene complement(2795807..2797117) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" downshifts complement(2795829) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" CDS complement(2797107..2797802) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" gene complement(2797107..2797802) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" CDS complement(2797817..2798794) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" gene complement(2797817..2798794) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" CDS complement(2798824..2799810) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" gene complement(2798824..2799810) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" promotor_-35 2799680..2799689 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2799696 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2799702..2799717 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2799804..2800682) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" gene complement(2799804..2800682) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" CDS complement(2800675..2801067) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" gene complement(2800675..2801067) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" S_feature complement(2801068..2801312) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2801101..2801238) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" gene complement(2801101..2801238) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" downshifts 2801236 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" promotor_-10 complement(2801307..2801326) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801312) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" promotor_-35 complement(2801340..2801347) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2801393..2801665) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" gene complement(2801393..2801665) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" downshifts complement(2801400) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2801705..2801716) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2801709..2801717 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2801709) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" upshifts 2801720 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" promotor_-10 2801731..2801749 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2801731..2801737) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2801760..2801765 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2801779..2801798 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2801786 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" CDS 2801827..2802795 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" gene 2801827..2802795 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" CDS 2802792..2803376 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" gene 2802792..2803376 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" downshifts 2803340 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" CDS complement(2803366..2804469) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /translation="MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQ ATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDF RMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLL ELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVA YSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMM DRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASG KTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC*" gene complement(2803366..2804469) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" downshifts complement(2803407) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" CDS complement(2804490..2805269) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /EC_number="3.1.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11796336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11796336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospholipase component of bacilysocin synthesisor export" /protein_id="NP_390929.1" /db_xref="EnsemblGenomes-Gn:BSU30510" /db_xref="EnsemblGenomes-Tr:CAB15029" /db_xref="GOA:O34705" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13900" /db_xref="UniProtKB/Swiss-Prot:O34705" /translation="MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGD LPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQR NPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEA DQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWF NGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI*" gene complement(2804490..2805269) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" promotor_-35 2804912..2804919 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2804934..2804953 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2804951 /Source="Nicolas_upshifts" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" S_feature complement(2805270..2805849) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" CDS 2805318..2805833 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22868757; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of the carbonic anhydrase family" /protein_id="NP_390930.1" /db_xref="EnsemblGenomes-Gn:BSU30520" /db_xref="EnsemblGenomes-Tr:CAB15030" /db_xref="GOA:O34696" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG13896" /db_xref="UniProtKB/Swiss-Prot:O34696" /translation="MIYPYKEHKPDIHPTAFIADNATITGDVVIGEQSSIWFSVVIRG DVAPTRIGNRVNIQDLSCLHQSPNKTLLIEDDATIGHQVTLHSAVIRKNALIGMGSII LDGAEIGEGAFIGAGSLVPPGKIIPPGHLAFGRPAKVIRPLTEEDRKDMQRIRSEYVE KGQYYKFLQQT*" gene 2805318..2805833 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" promotor_-10 complement(2805840..2805859) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2805849) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" S_feature complement(2805851..2805985) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2805871..2805878) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2805960..2805979) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2805985) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" CDS complement(2806078..2807469) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" gene complement(2806078..2807469) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" downshifts complement(2806086) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" S_feature complement(2807470..2807604) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2807605..2809503) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" gene complement(2807605..2809503) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" promotor_-35 2808661..2808667 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2808682..2808693 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2808694 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2809504..2809627) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2809653..2810855) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" gene complement(2809653..2810855) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" downshifts complement(2809672) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" promotor_-10 complement(2810898..2810909) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810904) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" S_feature complement(2810906..2811022) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2810923..2810929) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2811023..2811161) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(2811023..2811161) /gene="mswG" /locus_tag="BSU_misc_RNA_50" downshifts 2811121 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" promotor_-10 complement(2811170..2811189) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2811185) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" promotor_-35 complement(2811206..2811210) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2811282..2811289 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2811301 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" promotor_-10 2811303..2811322 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2811358..2812941 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" gene 2811358..2812941 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" downshifts 2812930 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" CDS complement(2812980..2813222) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" gene complement(2812980..2813222) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" downshifts complement(2812994) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" CDS complement(2813274..2814047) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" gene complement(2813274..2814047) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" S_feature complement(2814048..2814138) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2814114..2814123 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2814127..2814146) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2814135 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" promotor_-10 2814136..2814155 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2814140) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" promotor_-35 complement(2814161..2814168) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2814198..2815202 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" gene 2814198..2815202 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" CDS 2815215..2815997 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" gene 2815215..2815997 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" S_feature complement(2815219..2816767) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2815972..2816784 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" gene 2815972..2816784 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" downshifts 2816769 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" CDS complement(2816811..2817287) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" gene complement(2816811..2817287) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" downshifts complement(2816812) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" misc_feature complement(2817317..2817336) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2817330) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" S_feature complement(2817332..2817466) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2817466) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" promotor_-10 complement(2817468..2817479) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2817494..2817500) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2817496..2817900) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" gene complement(2817496..2817900) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" promotor_-10 complement(2817928..2817947) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2817945) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" S_feature complement(2817947..2818033) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2817960..2817969) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2818066..2818503) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" gene complement(2818066..2818503) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" downshifts complement(2818078) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2818520..2818538) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2818538) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" S_feature complement(2818540..2818765) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2818553..2818559) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2818595..2818614 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2818596..2818772 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" gene 2818596..2818772 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" upshifts 2818597 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" CDS complement(2818766..2819203) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" gene complement(2818766..2819203) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" downshifts 2818792 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2819222..2819241) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2819243) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" promotor_-35 complement(2819252..2819260) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2819323..2819796) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" gene complement(2819323..2819796) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" downshifts complement(2819332) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" downshifts complement(2819419) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" S_feature complement(2819797..2820148) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2819868..2819875 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2819888..2819907 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2819893 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2819925..2820152 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" gene 2819925..2820152 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" CDS complement(2820149..2820712) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" gene complement(2820149..2820712) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" misc_feature complement(2820737..2820756) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2820752) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" CDS complement(2820806..2821054) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" gene complement(2820806..2821054) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" downshifts complement(2820827) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" promotor_-10 complement(2821082..2821101) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2821115..2821122) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2821119) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" promotor_-35 2821181..2821187 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2821201..2821212 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2821213 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" CDS 2821259..2822590 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" gene 2821259..2822590 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" CDS 2822634..2823674 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" gene 2822634..2823674 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" promotor_-35 2823668..2823674 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2823689..2823700 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2823699 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" CDS 2823728..2823886 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" gene 2823728..2823886 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" downshifts 2823875 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" CDS complement(2823905..2824792) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" gene complement(2823905..2824792) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" downshifts complement(2823928) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" CDS complement(2824782..2826089) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" gene complement(2824782..2826089) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" CDS complement(2826095..2826847) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" gene complement(2826095..2826847) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" CDS complement(2826866..2827786) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" gene complement(2826866..2827786) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" promotor_-10 complement(2827822..2827833) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2827823) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2827825..2827916) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2827847..2827853) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2827901 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2827902..2827921) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2827904..2827916 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2827916) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" S_feature complement(2827918..2827999) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2827936..2827943) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2827999) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" promotor_-10 complement(2828008..2828027) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2828041..2828048) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2828066..2829181) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" gene complement(2828066..2829181) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" downshifts complement(2828109) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" CDS complement(2829178..2830638) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" gene complement(2829178..2830638) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" promotor_-10 complement(2830081..2830099) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2830085) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" promotor_-35 complement(2830114..2830120) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2830727) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" CDS complement(2830729..2831544) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" gene complement(2830729..2831544) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" CDS complement(2831579..2832403) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" gene complement(2831579..2832403) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" promotor_-10 complement(2831661..2831680) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2831661) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" promotor_-35 complement(2831696..2831699) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2831827) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" promotor_-10 complement(2831837..2831848) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2831863..2831869) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2832391..2834133) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" gene complement(2832391..2834133) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" CDS complement(2834130..2835545) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" gene complement(2834130..2835545) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" S_feature complement(2835546..2835658) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2835638..2835657) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2835658) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" S_feature complement(2835660..2835810) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2835673..2835676) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2835771..2835777 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2835791..2835810) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2835791..2835802 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2835799 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" upshifts complement(2835810) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" promotor_-35 complement(2835824..2835833) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2835835..2836554 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" gene 2835835..2836554 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" S_feature complement(2835905..2836562) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2836543 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" CDS complement(2836563..2837381) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" gene complement(2836563..2837381) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" promotor_-10 complement(2837402..2837421) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837416) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" promotor_-35 complement(2837436..2837444) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2837482..2837490 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2837503..2837522 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2837504 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" CDS 2837553..2838839 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" gene 2837553..2838839 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" CDS 2838836..2839786 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" gene 2838836..2839786 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" CDS 2839789..2841012 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" gene 2839789..2841012 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" downshifts complement(2840936) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" S_feature 2841013..2841580 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2841086..2841517) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" gene complement(2841086..2841517) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" downshifts complement(2841112) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" CDS complement(2841519..2842574) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" gene complement(2841519..2842574) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" CDS complement(2842589..2843722) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" gene complement(2842589..2843722) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" promotor_-10 complement(2843755..2843774) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843774) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" promotor_-35 complement(2843787..2843796) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2843860..2843869 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2843883..2843902 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2843885 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" CDS 2843912..2844985 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" gene 2843912..2844985 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" promotor_-35 2844209..2844215 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2844226 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" promotor_-10 2844229..2844240 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2844974 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" promotor_-35 2845012..2845018 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2845033 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" promotor_-10 2845034..2845052 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2845065..2845532 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" gene 2845065..2845532 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" downshifts 2845504 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" CDS complement(2845563..2847959) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" gene complement(2845563..2847959) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" downshifts complement(2845578) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" CDS complement(2847946..2849400) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" gene complement(2847946..2849400) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" CDS complement(2849397..2850428) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" gene complement(2849397..2850428) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" CDS complement(2850452..2851594) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" gene complement(2850452..2851594) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" CDS complement(2851591..2853474) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" gene complement(2851591..2853474) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" S_feature 2852300..2853719 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2853506..2853521) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2853519) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" promotor_-35 complement(2853536..2853541) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2853586) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" tRNA complement(2853707..2853778) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2853707..2853778) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" tRNA complement(2853804..2853894) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2853804..2853894) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" tRNA complement(2853898..2853972) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2853898..2853972) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" tRNA complement(2853983..2854059) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2853983..2854059) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" tRNA complement(2854075..2854148) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854075..2854148) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" tRNA complement(2854159..2854234) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854159..2854234) /gene="trnB-His" /locus_tag="BSU_tRNA_67" tRNA complement(2854252..2854327) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854252..2854327) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" tRNA complement(2854340..2854416) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854340..2854416) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" tRNA complement(2854428..2854504) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854428..2854504) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" tRNA complement(2854522..2854614) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854522..2854614) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" tRNA complement(2854621..2854697) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854621..2854697) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" tRNA complement(2854700..2854776) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854700..2854776) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" tRNA complement(2854796..2854868) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854796..2854868) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" tRNA complement(2854874..2854950) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854874..2854950) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" tRNA complement(2854966..2855042) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2854966..2855042) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" tRNA complement(2855052..2855137) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2855052..2855137) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" tRNA complement(2855152..2855226) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2855152..2855226) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" tRNA complement(2855232..2855318) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2855232..2855318) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" tRNA complement(2855329..2855404) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2855329..2855404) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" tRNA complement(2855442..2855517) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2855442..2855517) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" tRNA complement(2855550..2855625) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2855550..2855625) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" rRNA complement(2855646..2855763) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2855646..2855763) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" rRNA complement(2855819..2858746) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2855819..2858746) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" rRNA complement(2858914..2860468) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2858914..2860468) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" S_feature complement(2860469..2860760) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2860596..2860604 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2860602 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2860712 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2860733..2860752) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2860760) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" S_feature complement(2860762..2861728) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2860766..2860773) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2860885..2860888 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2860900 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" promotor_-10 2860903..2860922 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2860933..2861034 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 2860933..2861034 /gene="tswC" /locus_tag="BSU_misc_RNA_51" downshifts 2861033 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" CDS 2861134..2861712 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" gene 2861134..2861712 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" downshifts 2861702 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" CDS complement(2861754..2862275) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" gene complement(2861754..2862275) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" downshifts complement(2861772) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" downshifts complement(2861844) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" CDS complement(2862293..2863822) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" gene complement(2862293..2863822) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" CDS complement(2863843..2864367) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" gene complement(2863843..2864367) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" promotor_-10 complement(2864411..2864426) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2864417) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" S_feature complement(2864419..2864506) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2864438..2864447) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2864491..2864509) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2864501 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" misc_feature 2864505..2864524 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2864506) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" promotor_-35 complement(2864524..2864529) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2864535..2865023 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" gene 2864535..2865023 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" downshifts 2865000 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" CDS complement(2865029..2865607) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" gene complement(2865029..2865607) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" S_feature 2865045..2865436 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2865056) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2865641..2865660) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2865650) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" promotor_-35 complement(2865674..2865681) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2865695..2866903) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" gene complement(2865695..2866903) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" downshifts complement(2865716) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" promotor_-10 complement(2866672..2866691) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2866684) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2866706..2866713) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2866920..2868392) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" gene complement(2866920..2868392) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" promotor_-10 complement(2868443..2868462) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2868444) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" promotor_-35 complement(2868477..2868484) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2868504..2868510 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2868524..2868543 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2868539 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" CDS 2868591..2869133 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" gene 2868591..2869133 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" downshifts 2869116 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" promotor_-35 2869210..2869217 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2869230..2869330 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2869230 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" promotor_-10 2869232..2869251 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2869331..2869876 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" gene 2869331..2869876 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" downshifts 2869863 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2869968..2869975 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2869989..2870008 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2869996 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" misc_RNA 2870001..2870169 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" gene 2870001..2870169 /gene="swdA" /locus_tag="BSU_misc_RNA_52" downshifts 2870150 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" CDS 2870242..2870910 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" gene 2870242..2870910 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" CDS 2870917..2872254 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" gene 2870917..2872254 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" downshifts 2872240 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" CDS complement(2872290..2872553) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" gene complement(2872290..2872553) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" downshifts complement(2872308) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" promotor_-10 complement(2872593..2872612) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872595) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" promotor_-35 complement(2872625..2872632) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2872662..2873510) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" gene complement(2872662..2873510) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" promotor_-10 complement(2873555..2873574) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2873565) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" promotor_-35 complement(2873589..2873596) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2873671..2875206) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" gene complement(2873671..2875206) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" downshifts complement(2873680) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" promotor_no_box 2874864..2874964 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2874924 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2874990 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" S_feature complement(2875207..2875374) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2875363..2875382) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2875374) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" S_feature complement(2875376..2876253) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2875397..2875404) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2875616..2875625 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2875639..2875658 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2875639 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" CDS 2875691..2876176 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" gene 2875691..2876176 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" S_feature 2876177..2876463 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2876283..2876355) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" gene complement(2876283..2876355) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" downshifts complement(2876298) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" downshifts complement(2876342) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" promotor_-10 complement(2876366..2876385) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2876386) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" promotor_-35 complement(2876400..2876403) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2876420 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" CDS complement(2876463..2877293) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" gene complement(2876463..2877293) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" downshifts complement(2876474) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" S_feature complement(2877294..2877385) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2877386..2878552) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" gene complement(2877386..2878552) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" promotor_-35 2878548..2878552 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2878560..2878574 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2878576..2878595) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2878576 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2878595) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" promotor_-35 complement(2878609..2878616) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2878674..2878681 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2878687 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" promotor_-10 2878692..2878711 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2878734..2879720 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" gene 2878734..2879720 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" downshifts 2879691 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" CDS complement(2879761..2881035) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" gene complement(2879761..2881035) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" downshifts complement(2879774) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" CDS complement(2881061..2881375) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" gene complement(2881061..2881375) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" CDS complement(2881393..2882850) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" gene complement(2881393..2882850) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" CDS complement(2882855..2883631) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" gene complement(2882855..2883631) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" misc_feature complement(2883665..2883684) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2883681) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" CDS complement(2883688..2885757) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" gene complement(2883688..2885757) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" promotor_-10 complement(2885790..2885809) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2885802) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" promotor_-35 complement(2885823..2885829) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2885895..2887883) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" gene complement(2885895..2887883) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" downshifts complement(2885914) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2887887..2887894 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2887904..2887922) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2887910..2887929 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2887917) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" upshifts 2887926 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2887936..2887943) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2887992 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" CDS complement(2887997..2889982) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" gene complement(2887997..2889982) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" downshifts complement(2888002) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2890003..2890021) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2890018) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" S_feature complement(2890020..2890107) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2890035..2890042) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2890108..2892096) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" gene complement(2890108..2892096) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" promotor_-10 complement(2892121..2892139) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2892136) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" promotor_-35 complement(2892153..2892160) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2892273..2894261) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" gene complement(2892273..2894261) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" downshifts complement(2892292) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" promotor_-10 complement(2894282..2894300) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2894303) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" promotor_-35 complement(2894313..2894320) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2894363..2894372 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2894386..2894405 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2894389 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" CDS 2894419..2895156 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" gene 2894419..2895156 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" promotor_-10 complement(2894444..2894463) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2894452) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" promotor_-35 complement(2894479..2894483) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2895157..2897977 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2895170..2895424) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" gene complement(2895170..2895424) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" downshifts complement(2895196) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" S_feature complement(2895425..2895681) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2895682..2896080) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" gene complement(2895682..2896080) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" CDS complement(2896040..2896174) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" gene complement(2896040..2896174) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" promotor_-10 complement(2896123..2896142) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2896130) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" promotor_-35 complement(2896157..2896163) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2896200..2897864) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" gene complement(2896200..2897864) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" downshifts complement(2896216) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(2897172..2897191) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2897177) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2897205..2897212) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2897889..2897907) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2897906) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" promotor_-35 complement(2897923..2897928) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2897991..2899280) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" gene complement(2897991..2899280) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" downshifts complement(2898000) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" promotor_-35 2898809..2898815 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2898829..2898847 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2898835 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" S_feature 2898839..2899491 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2899324..2900001) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" gene complement(2899324..2900001) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" downshifts complement(2899334) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" S_feature 2899676..2900352 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2900036..2900055) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2900043..2900306) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" gene complement(2900043..2900306) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" upshifts complement(2900057) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" promotor_-35 complement(2900069..2900076) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2900318..2900336) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2900332) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" promotor_-35 complement(2900352..2900357) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2900353..2900685 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" gene 2900353..2900685 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" promotor_-35 2900370..2900376 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2900391..2900408 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2900402 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" CDS 2900682..2901668 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" gene 2900682..2901668 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" downshifts complement(2901643) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" CDS complement(2901665..2902069) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" gene complement(2901665..2902069) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" S_feature complement(2902070..2902128) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2902129..2902500) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" gene complement(2902129..2902500) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" CDS complement(2902559..2903911) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" gene complement(2902559..2903911) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" downshifts complement(2902570) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" promotor_-10 complement(2902726..2902744) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2902743) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" promotor_-35 complement(2902760..2902765) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2903884) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" misc_feature complement(2903887..2903898) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2903943..2903962) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2903949) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" S_feature complement(2903951..2904022) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2903977..2903980) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2904023..2905195) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" gene complement(2904023..2905195) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" S_feature 2904358..2905279 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2905228..2905247) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2905241) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" promotor_-35 complement(2905264..2905267) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2905299..2906462) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" gene complement(2905299..2906462) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" downshifts complement(2905314) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2906477..2906496) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2906495) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" S_feature complement(2906497..2906652) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2906511..2906518) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2906548..2906554 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2906569..2906587 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2906579 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" S_feature 2906580..2906638 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2906625..2906631 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2906627..2906638) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2906640 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" promotor_-10 2906645..2906656 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2906652..2906658) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2906652) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" S_feature complement(2906654..2906965) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2906692..2906928 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" gene 2906692..2906928 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" downshifts 2906888 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" downshifts 2906954 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" CDS complement(2907006..2907398) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" gene complement(2907006..2907398) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" downshifts complement(2907010) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(2907440..2907459) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2907447) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" S_feature complement(2907449..2907599) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2907475..2907479) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2907502..2907508 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2907515..2908499 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2907515 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" promotor_-10 2907523..2907541 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2907600..2908760) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" gene complement(2907600..2908760) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" promotor_-35 2908652..2908658 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2908670 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2908672..2908676 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2908761..2909261) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" gene complement(2908761..2909261) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" promotor_-10 complement(2909291..2909310) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2909297..2909303 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2909312) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" promotor_-10 2909318..2909329 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2909318 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" promotor_-35 complement(2909321..2909328) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2909330..2909408 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2909409..2910230 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" gene 2909409..2910230 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" downshifts 2910210 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" downshifts complement(2910257) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" CDS complement(2910259..2910519) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" gene complement(2910259..2910519) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" promotor_-35 2910509..2910512 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2910527..2910546 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2910539 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" S_feature 2910540..2910605 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2910545..2910564) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2910550) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" promotor_-35 complement(2910576..2910582) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2910606..2911769 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" gene 2910606..2911769 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" promotor_-35 2911832..2911838 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2911850..2911869 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2911860 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" CDS 2911895..2913181 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" gene 2911895..2913181 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" S_feature complement(2912897..2913639) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2913176..2913183 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2913197..2913216 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2913198 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" CDS 2913227..2913613 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" gene 2913227..2913613 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" downshifts 2913595 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" CDS complement(2913640..2914257) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" gene complement(2913640..2914257) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" promotor_-10 complement(2914292..2914310) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2914309) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" S_feature complement(2914311..2916399) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2914325..2914330) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2914373..2914376 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2914391..2914410 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2914402 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" CDS 2914468..2915646 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" gene 2914468..2915646 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" promotor_-35 2915684..2915690 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2915702..2915721 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2915707 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" CDS 2915739..2917613 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" gene 2915739..2917613 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" promotor_-10 complement(2916379..2916398) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2916399) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" promotor_-35 complement(2916412..2916421) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2917634..2918047 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" gene 2917634..2918047 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" downshifts 2918039 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" CDS complement(2918250..2918807) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" gene complement(2918250..2918807) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" misc_feature 2918271..2918290 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2918281 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" downshifts complement(2918291) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" S_feature 2918303..2918984 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2918833..2918852) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2918841) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" promotor_-35 complement(2918868..2918872) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2918985..2920586 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" gene 2918985..2920586 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" CDS 2920579..2921286 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" gene 2920579..2921286 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" downshifts 2921271 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" promotor_-35 2921450..2921457 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2921468..2921757 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2921468 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" promotor_-10 2921472..2921491 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2921758..2922837 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" gene 2921758..2922837 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" CDS 2922913..2924445 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" gene 2922913..2924445 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" CDS 2924438..2925484 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" gene 2924438..2925484 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" CDS 2925485..2926444 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" gene 2925485..2926444 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" S_feature 2926445..2926566 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2926539..2926542 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2926557..2926576 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2926568 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" CDS 2926598..2927944 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" gene 2926598..2927944 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" downshifts 2927927 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" CDS complement(2927980..2928195) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" gene complement(2927980..2928195) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" promotor_-35 2928135..2928141 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2928155..2928166 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2928159 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2928206..2928224) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2928213) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" promotor_-35 2928238..2928245 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2928240..2928245) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2928260..2928355 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2928260..2928279 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2928260 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" promotor_-35 2928318..2928322 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2928338..2928357 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2928357..2928506 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2928357 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" CDS 2928426..2930831 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" gene 2928426..2930831 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" CDS 2930824..2931255 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" gene 2930824..2931255 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" CDS 2931255..2931596 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" gene 2931255..2931596 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" promotor_no_box 2931487..2931587 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2931547 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" CDS 2931589..2933070 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" gene 2931589..2933070 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" S_feature complement(2932322..2934190) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2933076..2933552 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" gene 2933076..2933552 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" CDS 2933552..2933836 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" gene 2933552..2933836 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" CDS 2933820..2934194 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" gene 2933820..2934194 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" downshifts 2934165 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" CDS complement(2934233..2934613) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" gene complement(2934233..2934613) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" downshifts complement(2934235) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" CDS complement(2934632..2935276) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" gene complement(2934632..2935276) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" S_feature complement(2935277..2935356) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2935357..2937666) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" gene complement(2935357..2937666) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" promotor_-35 2936351..2936358 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2936372..2936391 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2936387 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 2937260..2938232 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2937260 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" misc_feature 2937272..2937288 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2937681..2937848) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" gene complement(2937681..2937848) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" CDS complement(2937836..2938735) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKELIKECLLSYTKGDTRCKT*" gene complement(2937836..2938735) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" S_feature complement(2938736..2938849) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2938843..2938862) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2938849) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" promotor_-35 complement(2938876..2938882) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2938920..2939060) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" gene complement(2938920..2939060) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" downshifts complement(2938949) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" S_feature complement(2939061..2939147) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2939131..2939150) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2939147) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" promotor_-35 complement(2939164..2939170) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2939247..2939265) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2939257) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2939280..2939286) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2939282..2939407 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" gene 2939282..2939407 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" S_feature complement(2939435..2939864) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2939460..2939465 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2939477) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" promotor_-10 2939480..2939498 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2939482 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" CDS 2939521..2939889 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" gene 2939521..2939889 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" CDS complement(2939865..2941094) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" gene complement(2939865..2941094) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" S_feature 2939890..2941203 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2941129..2941148) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2941148) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" downshifts 2941161 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(2941163..2941170) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2941231..2942703) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" gene complement(2941231..2942703) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" downshifts complement(2941241) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" misc_feature 2942584..2942588 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2942591 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2942701 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" CDS complement(2942719..2943270) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" gene complement(2942719..2943270) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" promotor_-10 complement(2943292..2943311) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2943305) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" promotor_-35 complement(2943324..2943331) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2943367..2943765) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" gene complement(2943367..2943765) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" S_feature complement(2943766..2943836) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2943837..2944085) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" gene complement(2943837..2944085) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" promotor_-10 complement(2944108..2944127) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944119) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" promotor_-35 complement(2944143..2944146) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2944158..2944379) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" gene complement(2944158..2944379) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" downshifts complement(2944185) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" downshifts 2944373 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" promotor_-10 complement(2944397..2944416) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944403) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" promotor_-35 complement(2944429..2944438) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2944439..2945548) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" gene complement(2944439..2945548) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" promotor_-35 2945200..2945207 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2945222..2945241 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2945231..2945625 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2945231 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" promotor_-10 complement(2945596..2945615) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2945612) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" S_feature complement(2945614..2946054) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2945617..2945619 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2945627 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2945629..2945634) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2945635..2945654 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2945663..2946052 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" gene 2945663..2946052 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" CDS complement(2946093..2946329) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" gene complement(2946093..2946329) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" downshifts complement(2946099) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2946349..2946368) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2946363) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" S_feature complement(2946365..2946505) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2946382..2946391) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2946506..2947036) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" gene complement(2946506..2947036) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" promotor_-10 complement(2947056..2947075) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2947067) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" S_feature complement(2947069..2947155) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2947087..2947095) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2947150..2947169) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2947157) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" promotor_-35 complement(2947183..2947192) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2947234..2947965) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" gene complement(2947234..2947965) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" downshifts complement(2947264) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" promotor_-10 complement(2947980..2947999) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2947991) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" promotor_-35 complement(2948014..2948021) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2948028..2948483) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" gene complement(2948028..2948483) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" promotor_-35 2948436..2948442 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2948457..2948475 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2948465..2950832 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2948465 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" CDS complement(2948515..2951745) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" gene complement(2948515..2951745) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" CDS complement(2951742..2956229) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" gene complement(2951742..2956229) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" promotor_-35 2955504..2955510 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2955525..2955543 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2955531..2956493 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2955531 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" CDS complement(2956290..2957645) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" gene complement(2956290..2957645) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" downshifts complement(2956311) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" CDS complement(2957660..2957899) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" gene complement(2957660..2957899) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" CDS complement(2957969..2958262) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" gene complement(2957969..2958262) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" downshifts complement(2957979) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" downshifts 2958256 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" S_feature complement(2958263..2958341) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2958304..2958311 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2958321..2958340) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2958322 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" promotor_-10 2958326..2958343 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2958341) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" promotor_-35 complement(2958355..2958362) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2958400..2958405 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2958420..2958439 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2958432..2958538 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2958432 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" promotor_-35 2958607..2958613 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2958627..2958646 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2958630 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2958735..2958738 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2958747 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" promotor_-10 complement(2958750..2958769) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2958754..2958773 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2958772) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2958783..2960051 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" gene 2958783..2960051 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" promotor_-35 complement(2958784..2958791) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2960111..2960130 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2960116 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" CDS 2960153..2961289 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" gene 2960153..2961289 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" downshifts 2961289 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" promotor_-35 2961338..2961346 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2961356 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" promotor_-10 2961358..2961376 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2961401..2962078 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" gene 2961401..2962078 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" downshifts 2962062 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" CDS complement(2962122..2962331) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" gene complement(2962122..2962331) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" downshifts complement(2962134) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" CDS complement(2962347..2969483) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" gene complement(2962347..2969483) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" CDS complement(2969503..2970441) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" gene complement(2969503..2970441) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" CDS complement(2970469..2972088) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" gene complement(2970469..2972088) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" CDS complement(2972117..2973313) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" gene complement(2972117..2973313) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" promotor_-35 2973161..2973168 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2973183..2973202 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2973190 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2973339..2974124) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" gene complement(2973339..2974124) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" S_feature complement(2974125..2974234) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2974229..2974248) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974234) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" S_feature complement(2974236..2974317) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2974262..2974269) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2974318..2975187) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" gene complement(2974318..2975187) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" S_feature complement(2975188..2975268) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2975252..2975271) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2975268) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" promotor_-35 complement(2975285..2975292) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2975401..2975997) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" gene complement(2975401..2975997) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" S_feature complement(2975998..2976082) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2976033..2976040 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2976050 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" promotor_-10 2976055..2976074 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2976076..2976090) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2976082) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" promotor_-35 complement(2976098..2976102) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2976098..2976700 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" gene 2976098..2976700 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" downshifts 2976686 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" CDS complement(2976770..2978098) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" gene complement(2976770..2978098) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" downshifts complement(2976786) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(2978152..2978171) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2978155) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" promotor_-35 complement(2978186..2978193) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2978245..2979747) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" gene complement(2978245..2979747) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" downshifts complement(2978260) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" misc_feature 2979312..2979326 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2979328 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2979748..2979822) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2979770..2979777 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2979788..2979807 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2979790..2979904 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2979790 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" misc_feature complement(2979817..2979836) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2979827) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" CDS 2979905..2980381 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" gene 2979905..2980381 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" downshifts 2980330 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" CDS complement(2980412..2981068) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" gene complement(2980412..2981068) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" downshifts complement(2980440) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2980716..2980725 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2980739..2980758 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2980756 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" S_feature 2980758..2981204 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2981082) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" promotor_-10 complement(2981084..2981095) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2981110..2981116) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2981161 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" CDS complement(2981172..2981492) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" gene complement(2981172..2981492) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" downshifts complement(2981186) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" S_feature 2981206..2981416 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2981358..2981458 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2981418..2981527 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2981418 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" downshifts 2981484 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2981511..2981530) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2981516) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" S_feature 2981529..2982080 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2981545..2981552) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2981546..2981689) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" gene complement(2981546..2981689) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" promotor_-10 complement(2981713..2981732) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2981734) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" promotor_-35 complement(2981748..2981751) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2981862..2983082) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" gene complement(2981862..2983082) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" downshifts complement(2981890) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" S_feature complement(2983083..2983210) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2983210) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" S_feature complement(2983212..2983276) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2983212..2983230) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2983246..2983251) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2983267..2983286) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2983275) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" promotor_-35 complement(2983301..2983308) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2983350..2983357 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2983369..2983388 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2983369 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" CDS 2983414..2984412 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" gene 2983414..2984412 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" promotor_-10 complement(2983437..2983455) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2983452) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2983472..2983477) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2984388 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" CDS complement(2984451..2984591) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" gene complement(2984451..2984591) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" downshifts complement(2984463) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" S_feature complement(2984592..2984721) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2984702..2984721) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2984721) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" S_feature complement(2984723..2984970) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2984735..2984741) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2984778..2984785 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2984799..2984818 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2984807 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" CDS 2984870..2985850 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" gene 2984870..2985850 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" upshifts complement(2984971) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" promotor_-10 complement(2984975..2984986) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2985000..2985006) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2985818 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" downshifts complement(2985923) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" CDS complement(2985924..2986547) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" gene complement(2985924..2986547) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" CDS complement(2986571..2987089) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" gene complement(2986571..2987089) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" misc_feature complement(2987136..2987155) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2987148) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2987150..2987258) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2987245..2987262) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2987256) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" promotor_-35 complement(2987277..2987284) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2987412) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" CDS complement(2987427..2987789) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" gene complement(2987427..2987789) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" promotor_-10 complement(2987820..2987839) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2987830) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" promotor_-35 complement(2987853..2987860) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2987868..2988722) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" gene complement(2987868..2988722) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" promotor_-10 complement(2988438..2988457) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2988446) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" promotor_-35 complement(2988470..2988479) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2988744..2988763) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2988758) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" promotor_-35 complement(2988778..2988781) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2988845..2990059) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" gene complement(2988845..2990059) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" promotor_-35 2989394..2989400 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2989415..2989433 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2989422 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" S_feature 2989426..2990195 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2990096..2990115) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2990101) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" promotor_-35 complement(2990130..2990137) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2990152 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" CDS complement(2990196..2990432) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" gene complement(2990196..2990432) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" S_feature 2990197..2990613 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2990214) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" promotor_-10 complement(2990397..2990398) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2990402..2990406) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2990404) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" promotor_-10 complement(2990447..2990466) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2990448) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" promotor_-35 complement(2990480..2990487) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2990590..2990595 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2990609..2990628 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2990615 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" CDS 2990695..2991762 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" gene 2990695..2991762 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" downshifts 2991746 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" CDS complement(2991788..2992114) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" gene complement(2991788..2992114) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" downshifts complement(2991811) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2992146..2992165) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2992163) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" promotor_-35 complement(2992178..2992185) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2992198..2992202 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2992214..2992549 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" gene 2992214..2992549 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" promotor_-10 2992215..2992234 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2992220 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" downshifts complement(2992339) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" downshifts 2992527 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" CDS complement(2992591..2994564) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" gene complement(2992591..2994564) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" downshifts complement(2992603) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2994579..2994597) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2994602) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" promotor_-35 complement(2994609..2994617) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2994672..2995601) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" gene complement(2994672..2995601) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" downshifts complement(2994685) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" CDS complement(2995598..2996656) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" gene complement(2995598..2996656) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" CDS complement(2996656..2997957) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" gene complement(2996656..2997957) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" promotor_-35 2997842..2997851 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2997866..2997885 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2997873 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2997958..2998039) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2998024..2998043) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998039) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" S_feature complement(2998041..2998157) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2998058..2998065) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2998158..2999177) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" gene complement(2998158..2999177) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" promotor_-35 2998985..2998990 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2999006..2999024 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2999010 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2999200..2999218) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2999207) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" promotor_-35 2999216..2999221 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2999234..2999239) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2999237..2999301 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2999237..2999255 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2999237 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" promotor_-35 2999274..2999283 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2999296..2999315 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2999303 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" CDS 2999330..2999830 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" gene 2999330..2999830 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" CDS complement(2999857..3000627) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" gene complement(2999857..3000627) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" downshifts complement(2999885) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" CDS complement(3000656..3001090) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" gene complement(3000656..3001090) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" CDS complement(3001114..3001389) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" gene complement(3001114..3001389) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" promotor_-10 complement(3001409..3001428) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3001434) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" S_feature complement(3001436..3002128) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(3001442..3001449) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3001452..3001458 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3001473..3001484 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3001481 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" CDS 3001504..3002136 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" gene 3001504..3002136 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" downshifts 3002097 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" CDS complement(3002152..3003048) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" gene complement(3002152..3003048) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" downshifts complement(3002173) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" S_feature complement(3003049..3003183) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(3003170..3003189) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(3003183) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" promotor_-35 complement(3003205..3003209) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 3003223..3003229 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3003243..3003254 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003255 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" CDS 3003283..3004263 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" gene 3003283..3004263 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" upshifts complement(3003361) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3003375..3003394) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3003411..3003414) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3004255 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" CDS complement(3004291..3005055) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" gene complement(3004291..3005055) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" downshifts complement(3004307) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3005069..3005087) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3005077) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" promotor_-35 complement(3005103..3005108) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3005128..3005433) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " gene complement(3005128..3005433) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" downshifts complement(3005136) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" promotor_-10 complement(3005447..3005466) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3005470) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" promotor_-35 complement(3005480..3005488) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3005498..3006886) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" gene complement(3005498..3006886) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" CDS complement(3006906..3007727) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" gene complement(3006906..3007727) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" CDS complement(3007745..3008593) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" gene complement(3007745..3008593) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" promotor_-35 3008112..3008117 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3008133..3008151 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3008147 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3008604..3008623) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3008619) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" CDS complement(3008631..3008978) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" gene complement(3008631..3008978) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" promotor_-10 complement(3008991..3009010) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3009010) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" promotor_-35 complement(3009024..3009030) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3009075..3010415) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" gene complement(3009075..3010415) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" downshifts complement(3009103) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" downshifts complement(3010159) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" promotor_-35 3010472..3010478 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3010492..3010511 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3010494..3010512) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3010500 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" S_feature 3010501..3010589 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(3010511) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3010528..3010533) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3010590..3012185 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" gene 3010590..3012185 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" CDS 3012330..3013679 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " gene 3012330..3013679 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" CDS 3013685..3014977 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" gene 3013685..3014977 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" CDS 3014990..3016474 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" gene 3014990..3016474 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" CDS 3016474..3016818 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" gene 3016474..3016818 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" promotor_-35 3016540..3016543 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3016561..3016580 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3016573 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3016793 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" S_feature complement(3016834..3017221) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 3017181..3017190 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3017203..3017222 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3017206 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" ncRNA complement(3017242..3017373) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" CDS 3017242..3017373 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " gene 3017242..3017373 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" gene complement(3017242..3017373) /gene="auzJ" /locus_tag="BSU_ncRNA_2" S_feature 3017374..3017442 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 3017409 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" CDS complement(3017579..3018100) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" gene complement(3017579..3018100) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" CDS complement(3018091..3020328) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" gene complement(3018091..3020328) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" CDS complement(3020329..3021162) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" gene complement(3020329..3021162) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" CDS complement(3021159..3021776) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" gene complement(3021159..3021776) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" downshifts complement(3021268) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" CDS complement(3021773..3022765) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" gene complement(3021773..3022765) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" S_feature complement(3022766..3022852) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(3022830..3022849) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3022852) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" promotor_-35 complement(3022863..3022868) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3022994..3024244) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" gene complement(3022994..3024244) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" CDS complement(3024261..3025499) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" gene complement(3024261..3025499) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" CDS 3025722..3025859 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" gene 3025722..3025859 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" promotor_-35 3025881..3025884 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3025899..3025918 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3025900 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" CDS 3025941..3026807 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" gene 3025941..3026807 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" downshifts 3026810 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" CDS complement(3026841..3027944) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" gene complement(3026841..3027944) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" downshifts complement(3026856) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" S_feature complement(3027945..3028878) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 3027982..3027989 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3028003..3028022 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3028013 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" promotor_-35 3028064..3028070 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3028081 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" promotor_-10 3028085..3028104 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3028126..3028854 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" gene 3028126..3028854 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" CDS complement(3028879..3029733) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" gene complement(3028879..3029733) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" misc_feature complement(3029066..3029085) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3029078) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" promotor_no_box complement(3029236..3029336) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3029276) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" CDS complement(3029747..3030649) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" gene complement(3029747..3030649) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" CDS complement(3030653..3031531) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" gene complement(3030653..3031531) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" CDS complement(3031589..3032857) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" gene complement(3031589..3032857) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" promotor_no_box 3032748..3032848 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3032808 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(3032928) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" CDS complement(3032938..3033924) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" gene complement(3032938..3033924) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" upshifts 3033871 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3033874..3033878 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3033967..3033986) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3033980) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" promotor_-35 complement(3034001..3034008) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3034138) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" CDS complement(3034140..3034514) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" gene complement(3034140..3034514) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" upshifts complement(3034578) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" promotor_-10 complement(3034585..3034596) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3034610..3034616) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3034617..3035735) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" gene complement(3034617..3035735) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" promotor_-10 complement(3035760..3035779) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3035766) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" S_feature complement(3035768..3036378) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(3035793..3035799) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3035832..3035841 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3035855..3035874 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3035859 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" promotor_-10 complement(3035872..3035887) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3035876) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" promotor_-35 complement(3035894..3035898) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3035894..3036040 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" gene 3035894..3036040 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" CDS 3036040..3036315 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" gene 3036040..3036315 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" upshifts complement(3036184) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3036200..3036214) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3036223..3036227) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3036295 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" CDS complement(3036379..3036762) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" gene complement(3036379..3036762) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" S_feature complement(3036763..3036872) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(3036873..3037151) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" gene complement(3036873..3037151) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" promotor_-10 complement(3037149..3037168) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3037173) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" promotor_-35 complement(3037183..3037190) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3037314..3037420) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(3037357) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" CDS complement(3037421..3038818) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" gene complement(3037421..3038818) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" downshifts 3038616 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" CDS complement(3038839..3039282) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" gene complement(3038839..3039282) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" CDS complement(3039272..3040492) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" gene complement(3039272..3040492) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" CDS complement(3040492..3041805) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" gene complement(3040492..3041805) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" CDS complement(3041823..3042608) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" gene complement(3041823..3042608) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" promotor_-10 complement(3042652..3042671) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3042653) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" promotor_-35 complement(3042685..3042692) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(3042709..3042728) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3042718) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" S_feature complement(3042720..3042801) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(3042744..3042748) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(3042765..3043012) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" gene complement(3042765..3043012) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" CDS complement(3042802..3042939) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" gene complement(3042802..3042939) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" S_feature complement(3042940..3043024) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(3043008..3043027) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043024) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" S_feature complement(3043026..3043132) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(3043043..3043046) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3043133..3043510) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" gene complement(3043133..3043510) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" promotor_-10 complement(3043527..3043538) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(3043533) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" promotor_-35 complement(3043552..3043558) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(3043595..3044419) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" gene complement(3043595..3044419) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" downshifts complement(3043603) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" downshifts complement(3043752) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" promotor_-35 3043779..3043784 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3043800..3043818 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3043802 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3044433..3045101) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" gene complement(3044433..3045101) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" CDS complement(3045094..3046119) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" gene complement(3045094..3046119) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" S_feature complement(3046120..3046224) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(3046225..3046331) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(3046225..3046331) /gene="mswH" /locus_tag="BSU_misc_RNA_53" downshifts 3046294 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" promotor_-10 complement(3046358..3046377) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3046370) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" S_feature complement(3046372..3046445) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(3046393..3046400) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3046446..3046790) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" gene complement(3046446..3046790) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" S_feature complement(3046791..3046896) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(3046897..3047217) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" gene complement(3046897..3047217) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" CDS complement(3047219..3047659) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" gene complement(3047219..3047659) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" CDS complement(3047659..3047895) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" gene complement(3047659..3047895) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" downshifts complement(3047671) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" upshifts complement(3047910) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" promotor_-10 complement(3047915..3047926) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3047941..3047947) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3047951..3048334) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" gene complement(3047951..3048334) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" promotor_-10 complement(3048361..3048380) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(3048372) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" promotor_-35 complement(3048393..3048400) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(3048401..3048757) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" gene complement(3048401..3048757) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" promotor_-10 complement(3048780..3048799) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(3048790) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" promotor_-35 complement(3048813..3048818) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(3048868..3050652) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" gene complement(3048868..3050652) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" downshifts complement(3048878) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" CDS complement(3050667..3051842) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " gene complement(3050667..3051842) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" CDS complement(3051853..3054222) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" gene complement(3051853..3054222) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" promotor_-35 3053641..3053646 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3053661..3053679 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3053664 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3054290..3054309) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(3054293) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" S_feature complement(3054301..3054567) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(3054323..3054330) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 3054348..3054354 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3054369..3054380 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3054391 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" CDS 3054397..3054543 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" gene 3054397..3054543 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" S_feature 3054544..3055570 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(3054568..3055476) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" gene complement(3054568..3055476) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" S_feature complement(3055477..3055999) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 3055571..3055816 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" gene 3055571..3055816 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" CDS 3055829..3056161 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" gene 3055829..3056161 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" promotor_-10 complement(3055982..3056001) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3055999) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" promotor_-35 complement(3056015..3056024) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3056150 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" promotor_-35 3056222..3056229 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3056243..3056262 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3056254 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" CDS 3056320..3056787 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" gene 3056320..3056787 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" CDS 3056784..3058409 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" gene 3056784..3058409 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" downshifts 3058394 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" CDS complement(3058445..3058828) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" gene complement(3058445..3058828) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" CDS complement(3058847..3059236) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" gene complement(3058847..3059236) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" CDS complement(3059258..3059587) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" gene complement(3059258..3059587) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" promotor_-10 complement(3059622..3059641) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3059629..3059636 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3059636) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3059651..3059670 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3059655..3059662) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3059661 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" CDS 3059721..3060608 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" gene 3059721..3060608 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" CDS complement(3060628..3060915) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" gene complement(3060628..3060915) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" downshifts complement(3060640) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" CDS complement(3060940..3061767) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " gene complement(3060940..3061767) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" downshifts complement(3060956) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" S_feature complement(3061768..3061905) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(3061890..3061909) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3061905) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" promotor_-35 complement(3061925..3061928) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3061985..3062422) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" gene complement(3061985..3062422) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" promotor_-10 complement(3062446..3062464) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(3062452) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" promotor_-35 complement(3062480..3062485) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(3062532..3064040) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" gene complement(3062532..3064040) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo downshifts complement(3062553) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" CDS complement(3064031..3064327) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" gene complement(3064031..3064327) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo promotor_-10 complement(3064350..3064369) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3064366) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" promotor_-35 complement(3064384..3064387) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3064404..3064409 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3064421..3064440 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3064421 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" CDS 3064461..3065303 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" gene 3064461..3065303 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" promotor_-35 3064833..3064839 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 3064854..3064865 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 3064862 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" promotor_-35 3065330..3065337 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3065346 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" promotor_-10 3065349..3065368 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3065393..3065854 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" gene 3065393..3065854 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" downshifts 3065830 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" CDS complement(3065898..3067274) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" gene complement(3065898..3067274) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" downshifts complement(3065906) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" S_feature complement(3067275..3067446) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(3067427..3067446) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3067446) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" promotor_-35 complement(3067457..3067464) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3067507..3067526) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 3067517..3067536 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3067519 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" upshifts complement(3067525) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" S_feature complement(3067527..3068590) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(3067541..3067548) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 3067552..3068229 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" gene 3067552..3068229 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" CDS 3068226..3069581 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" gene 3068226..3069581 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" S_feature complement(3068680..3069608) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 3069549 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" CDS complement(3069609..3069773) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" gene complement(3069609..3069773) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" promotor_-35 3069797..3069804 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3069818..3069837 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3069822..3069841) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3069828..3069940 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 3069828 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" upshifts complement(3069835) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3069837..3070115) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(3069855..3069862) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3069941..3070816 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" gene 3069941..3070816 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" promotor_-10 complement(3070105..3070124) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3070115) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3070117..3070658) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(3070138..3070145) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3070650..3070668) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3070658) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3070660..3070789) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(3070681..3070688) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3070791 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" downshifts complement(3070834) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" CDS complement(3070852..3072240) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" gene complement(3070852..3072240) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" upshifts complement(3072264) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" promotor_-10 complement(3072269..3072287) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3072298..3072306) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3072307..3072492) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" gene complement(3072307..3072492) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" downshifts 3072496 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" promotor_-10 complement(3072536..3072555) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3072545..3072551 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3072550) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" promotor_-10 3072565..3072576 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3072568 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" promotor_-35 complement(3072571..3072574) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3072610..3074058 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" gene 3072610..3074058 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" S_feature complement(3073606..3076249) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 3074027..3075124 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" gene 3074027..3075124 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" CDS 3075121..3076242 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" gene 3075121..3076242 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" CDS complement(3076250..3076885) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" gene complement(3076250..3076885) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" CDS complement(3076863..3077945) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" gene complement(3076863..3077945) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" CDS complement(3077942..3078667) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" gene complement(3077942..3078667) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" CDS complement(3078701..3079573) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" gene complement(3078701..3079573) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" promotor_-10 complement(3079592..3079611) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079612) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" promotor_-35 complement(3079626..3079629) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3079674..3080351) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" gene complement(3079674..3080351) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" downshifts complement(3079690) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" CDS complement(3080378..3080758) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" gene complement(3080378..3080758) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" promotor_-10 complement(3080781..3080800) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3080801) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" promotor_-35 complement(3080815..3080818) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3080920..3082188) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" gene complement(3080920..3082188) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" downshifts complement(3080933) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3082222..3082241) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3082233) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" promotor_-35 complement(3082256..3082263) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3082359) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" CDS complement(3082365..3082946) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" gene complement(3082365..3082946) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" CDS complement(3082969..3084297) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" gene complement(3082969..3084297) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" CDS complement(3084297..3085358) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" gene complement(3084297..3085358) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" CDS complement(3085321..3086265) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" gene complement(3085321..3086265) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" S_feature complement(3086266..3086535) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(3086374..3086504) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" gene complement(3086374..3086504) /gene="srbL" /locus_tag="BSU_misc_RNA_85" promotor_-10 complement(3086512..3086531) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3086535) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" S_feature complement(3086537..3087464) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(3086547..3086554) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3086597..3086604 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3086619..3086638 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3086623 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" CDS 3086663..3087454 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" gene 3086663..3087454 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" downshifts 3087325 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" downshifts 3087435 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" CDS complement(3087492..3088370) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" gene complement(3087492..3088370) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" downshifts complement(3087509) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(3088394..3088412) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3088413) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" promotor_-35 complement(3088426..3088432) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3088442..3090184) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" gene complement(3088442..3090184) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" CDS complement(3090181..3090894) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" gene complement(3090181..3090894) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" misc_feature complement(3090925..3090944) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3090943) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" CDS complement(3091047..3091286) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" gene complement(3091047..3091286) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" downshifts complement(3091054) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(3091282..3091300) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3091290..3091820) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" gene complement(3091290..3091820) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" upshifts complement(3091291) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" promotor_-35 complement(3091315..3091321) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3091823..3091842) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3091830) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" CDS 3091835..3092173 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" gene 3091835..3092173 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" promotor_-35 complement(3091857..3091864) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3091873..3091892) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3091885) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" promotor_-35 complement(3091907..3091913) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 3091919..3092019 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 3091979 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" promotor_no_box 3092147..3092247 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3092207..3092293 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 3092207 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" CDS 3092294..3093451 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" gene 3092294..3093451 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" downshifts 3093437 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" CDS 3093512..3093922 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" gene 3093512..3093922 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" downshifts 3093921 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" CDS complement(3093956..3095185) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" gene complement(3093956..3095185) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" downshifts complement(3093973) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" CDS complement(3095178..3095867) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" gene complement(3095178..3095867) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" CDS complement(3095851..3097044) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" gene complement(3095851..3097044) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" promotor_-10 complement(3097088..3097107) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3097101) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" promotor_-35 complement(3097122..3097129) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3097215..3098024) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" gene complement(3097215..3098024) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" downshifts complement(3097232) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3097371..3097380 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3097393..3097412 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3097397 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3098040..3099050) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" gene complement(3098040..3099050) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" CDS complement(3099050..3100204) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" gene complement(3099050..3100204) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" promotor_-10 complement(3100137..3100156) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3100154) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" promotor_-35 complement(3100168..3100175) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3100216..3100223 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3100238..3100257 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3100247 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" CDS 3100302..3101249 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" gene 3100302..3101249 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" downshifts 3101225 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" downshifts 3101269 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" downshifts 3101423 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" CDS complement(3101484..3102893) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" gene complement(3101484..3102893) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" downshifts complement(3101499) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" promotor_-35 3102311..3102315 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3102333..3102349 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3102340 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" S_feature 3102347..3103314 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(3102995) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" misc_RNA complement(3102997..3103176) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" gene complement(3102997..3103176) /gene="kswB" /locus_tag="BSU_misc_RNA_54" promotor_-10 complement(3103206..3103223) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3103217) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" promotor_-35 complement(3103238..3103245) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3103271 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" CDS complement(3103293..3103433) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" gene complement(3103293..3103433) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" downshifts complement(3103303) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" upshifts complement(3103461) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" S_feature complement(3103463..3104051) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(3103466..3103477) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(3103491..3103497) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 3103523..3103530 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3103544 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" promotor_-10 3103546..3103565 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3103600..3104082 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" gene 3103600..3104082 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" promotor_-35 3104096..3104103 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3104117..3104136 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3104129 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" CDS 3104182..3106035 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" gene 3104182..3106035 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" downshifts 3106021 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" CDS complement(3106063..3106989) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" gene complement(3106063..3106989) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" downshifts complement(3106075) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3107001..3107020) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3107022) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" promotor_-35 complement(3107036..3107039) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3107058..3107077 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3107067 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" CDS 3107100..3107882 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" gene 3107100..3107882 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" CDS 3107854..3108546 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" gene 3107854..3108546 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" downshifts 3108538 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" CDS complement(3108577..3109407) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" gene complement(3108577..3109407) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" downshifts complement(3108583) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" promotor_-35 3109270..3109274 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3109290..3109294 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3109299 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3109409 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" promotor_-10 complement(3109437..3109456) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109455) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" promotor_-35 complement(3109471..3109478) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3109563..3109569 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3109583 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" promotor_-10 3109584..3109602 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3109630..3110115 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" gene 3109630..3110115 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" downshifts 3110114 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" CDS complement(3110159..3112171) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" gene complement(3110159..3112171) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" downshifts complement(3110167) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" misc_feature complement(3111837..3111841) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3111839) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3112172..3112323) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(3112300..3112318) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3112323) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" CDS complement(3112426..3114141) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" gene complement(3112426..3114141) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" downshifts complement(3112433) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" CDS complement(3114167..3115984) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" gene complement(3114167..3115984) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" promotor_-10 complement(3116026..3116045) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3116035..3116042 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3116045) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" upshifts 3116048 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3116055..3116074 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3116058..3116065) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3116155..3118479) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" gene complement(3116155..3118479) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" downshifts complement(3116173) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" promotor_-35 3118499..3118506 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3118521..3118540 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(3118522..3118537) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3118525 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3118527) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" promotor_-10 complement(3118572..3118591) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3118581) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" promotor_-35 complement(3118607..3118613) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3118617..3118636) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3118637) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" promotor_-35 complement(3118650..3118658) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3118664) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" CDS complement(3118677..3119285) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" gene complement(3118677..3119285) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" promotor_-10 complement(3119324..3119343) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3119341) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" promotor_-35 complement(3119359..3119363) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3119472..3119888) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" gene complement(3119472..3119888) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" downshifts complement(3119482) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" CDS complement(3119893..3120561) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" gene complement(3119893..3120561) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" promotor_-10 complement(3120613..3120632) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3120628) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" downshifts complement(3120639) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3120646..3120651) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3120681..3122789) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" gene complement(3120681..3122789) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" S_feature complement(3122781..3122882) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(3122876..3122895) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122882) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" promotor_-35 complement(3122911..3122918) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3122949..3125357) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" gene complement(3122949..3125357) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" downshifts complement(3122971) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" downshifts complement(3123037) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3125358..3125440) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(3125441..3125650) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" gene complement(3125441..3125650) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" promotor_-10 complement(3125674..3125693) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(3125695) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" promotor_-35 complement(3125706..3125712) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(3125724..3126029) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " gene complement(3125724..3126029) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" misc_feature 3125993..3126012 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3126004 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3126043..3126062) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(3126069) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" promotor_-35 complement(3126076..3126082) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 3126121..3126127 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3126142..3126160 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3126150 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" CDS 3126157..3127233 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" gene 3126157..3127233 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" downshifts 3127220 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" CDS complement(3127270..3127905) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" gene complement(3127270..3127905) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" downshifts complement(3127283) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" S_feature complement(3127906..3128003) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(3127983..3128002) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3128003) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" promotor_-35 complement(3128016..3128022) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3128065..3129960) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" gene complement(3128065..3129960) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" promotor_-10 complement(3130011..3130022) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130011) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3130037..3130043) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3130110) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" CDS complement(3130123..3130524) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" gene complement(3130123..3130524) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" CDS complement(3130521..3130880) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" gene complement(3130521..3130880) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" CDS complement(3130877..3131449) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" gene complement(3130877..3131449) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" promotor_-10 complement(3131487..3131506) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3131492) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" promotor_-35 complement(3131520..3131527) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3131560..3132354) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" gene complement(3131560..3132354) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" promotor_-10 complement(3132375..3132393) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132387) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" promotor_-35 complement(3132408..3132414) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3132420..3132439) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132431) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" S_feature complement(3132433..3132498) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(3132453..3132460) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(3132540..3132899) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" gene complement(3132540..3132899) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" downshifts complement(3132543) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3132883..3132891) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132893) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" promotor_-35 complement(3132906..3132911) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3132951..3132970) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132959) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" S_feature complement(3132961..3133025) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(3132983..3132987) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3133025) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" promotor_-10 complement(3133026..3133045) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(3133060..3133067) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(3133076..3133546) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" gene complement(3133076..3133546) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" promotor_no_box 3133373..3133473 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3133433 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3133543 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" promotor_-10 complement(3133591..3133610) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3133597) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" S_feature complement(3133599..3133690) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(3133626..3133629) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(3133691..3136030) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" gene complement(3133691..3136030) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" promotor_-35 3134791..3134794 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3134810..3134813 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3134819 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3136049..3136789) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" gene complement(3136049..3136789) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" promotor_-10 complement(3136445..3136463) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(3136457) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" promotor_-35 complement(3136478..3136484) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(3136817..3136835) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3136831) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" downshifts complement(3136919) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" CDS complement(3136921..3137151) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" gene complement(3136921..3137151) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" promotor_-10 complement(3137181..3137200) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3137202) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" promotor_-35 complement(3137215..3137218) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 3137240..3137246 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137260..3137271 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137261 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" CDS 3137300..3138070 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" gene 3137300..3138070 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" promotor_-35 3137322..3137330 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137341..3137359 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137371 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3138110..3138343) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" gene complement(3138110..3138343) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" promotor_-35 3138434..3138441 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 3138449 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" promotor_-10 3138453..3138472 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 3138495..3138902 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" gene 3138495..3138902 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" CDS 3138932..3139351 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" gene 3138932..3139351 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" promotor_-35 3139389..3139396 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3139410..3139429 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3139417 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" CDS 3139443..3139769 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" gene 3139443..3139769 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" S_feature 3139770..3139854 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 3139825..3139832 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3139845..3139863 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3139856 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" CDS 3139894..3141594 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" gene 3139894..3141594 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" S_feature complement(3140610..3141603) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 3141572 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" CDS complement(3141634..3142314) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" gene complement(3141634..3142314) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" downshifts complement(3141648) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" promotor_-35 3142008..3142014 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3142029..3142047 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3142034..3144785 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 3142034 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" CDS complement(3142331..3143251) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" gene complement(3142331..3143251) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" CDS complement(3143263..3143916) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " gene complement(3143263..3143916) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" CDS complement(3143933..3145078) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" gene complement(3143933..3145078) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" S_feature complement(3145079..3145146) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(3145146) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" promotor_-10 complement(3145147..3145166) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3145177..3145181 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3145181..3145184) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3145197..3145215 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3145202 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" promotor_-35 3145297..3145301 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3145317..3145336 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3145320 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" CDS 3145362..3145895 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" gene 3145362..3145895 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" S_feature complement(3145562..3146081) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 3145884 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" promotor_-35 3146018..3146025 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3146038..3146116 /Source="Nicolas_S_feature" /locus_tag="new_3464210_3464288" /HighExp="T-1.10H, T2.30H, T4.0H, T5.0H, T-2.40H, T2.0H, T-0.40H, M9-stat, T-5.40H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1293" upshifts 3146038 /Source="Nicolas_upshifts" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" promotor_-10 3146040..3146059 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3146066..3146080) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3146081) /Source="Nicolas_upshifts" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" promotor_-35 complement(3146090) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3146117..3146593 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391255.1" /db_xref="EnsemblGenomes-Gn:BSU33750" /db_xref="EnsemblGenomes-Tr:CAB15380" /db_xref="GOA:O34889" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG14074" /db_xref="UniProtKB/Swiss-Prot:O34889" /translation="MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPT EENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCT NLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV*" gene 3146117..3146593 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" promotor_-10 complement(3146142..3146161) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3146152) /Source="Nicolas_upshifts" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" promotor_-35 complement(3146173..3146180) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3146590..3147561 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16469701, 16850406, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16469701, 16850406, 17069462, 23687264; Product type t : transporter" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391256.1" /db_xref="EnsemblGenomes-Gn:BSU33760" /db_xref="EnsemblGenomes-Tr:CAB15381" /db_xref="GOA:O34616" /db_xref="InterPro:IPR007782" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG14075" /db_xref="UniProtKB/Swiss-Prot:O34616" /translation="MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDIL FSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWY ICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYI MTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNF IVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALI IYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS*" gene 3146590..3147561 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" promotor_no_box 3147398..3147498 /Source="Nicolas_upshift_promotors" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3147458 /Source="Nicolas_upshifts" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" promotor_-10 complement(3147470..3147487) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3147491) /Source="Nicolas_upshifts" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" S_feature complement(3147493..3147895) /Source="Nicolas_S_feature" /locus_tag="new_3465665_3466067_c" /HighExp="Gly, Lbstat, BT, S8, T1.30H, C30, M9-stat, C90, Sw, HiTm" /AntisenseName="spbC" /AntisenseCor="-0.16053929530879699" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1294" promotor_-35 complement(3147504..3147506) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3147522) /Source="Nicolas_upshifts" /id="D1751" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="3.26001" /MaxDrop="4.09728" /score="-7.06061287" /energy="-10.3" /TU="NA" /idTUdmin="U2665" /TUdmin=286 /isTUend="FALSE" CDS 3147604..3148215 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="precursor of killing factor SdpC" /protein_id="NP_391257.1" /db_xref="EnsemblGenomes-Gn:BSU33770" /db_xref="EnsemblGenomes-Tr:CAB15382" /db_xref="GOA:O34344" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG14076" /db_xref="UniProtKB/Swiss-Prot:O34344" /translation="MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYF RGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSID SKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNA VALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ*" gene 3147604..3148215 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" S_feature complement(3147897..3147983) /Source="Nicolas_S_feature" /locus_tag="new_3466069_3466155_c" /HighExp="T1.30H, Gly, T2.0H, BT, S8, C30, Lbstat, C90, T1.0H, M9-stat" /AntisenseName="spbC" /AntisenseCor="-5.4790207146846799E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1295" downshifts complement(3147940) /Source="Nicolas_upshifts" /id="D1752" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="4.62458" /MaxDrop="2.00358" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-132" /isTUend="FALSE" S_feature complement(3147985..3148170) /Source="Nicolas_S_feature" /locus_tag="new_3466157_3466342_c" /HighExp="T1.30H, T2.0H, M9-stat, T1.0H, B60, T2.30H, T5.0H, B36, T3.30H, T0.30H" /AntisenseName="spbC" /AntisenseCor="-4.2394313806342503E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1296" downshifts complement(3148028) /Source="Nicolas_upshifts" /id="D1753" /incds=1 /nref=1 /ntot=14 /MaxReadThrough="4.27088" /MaxDrop="2.27366" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-220" /isTUend="FALSE" downshifts 3148195 /Source="Nicolas_upshifts" /id="D1754" /incds=0 /nref=207 /ntot=252 /MaxReadThrough="4.65014" /MaxDrop="7.52715" /score="19.8036228" /energy="-20" /TU="U2660,U2663" /idTUdmin="U2660" /TUdmin="-1099" /isTUend="FALSE" downshifts complement(3148215) /Source="Nicolas_upshifts" /id="D1755" /incds=0 /nref=14 /ntot=94 /MaxReadThrough="6.14809" /MaxDrop="5.58575" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2667" /TUdmin=33 /isTUend="FALSE" S_feature 3148240..3149378 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" CDS complement(3148262..3148885) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 15849754, 16850406, 20563570, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 15849754, 16850406, 20563570, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="integral membrane immunity regulator of autophagy" /protein_id="NP_391258.1" /db_xref="EnsemblGenomes-Gn:BSU33780" /db_xref="EnsemblGenomes-Tr:CAB15383" /db_xref="GOA:O32241" /db_xref="InterPro:IPR012867" /db_xref="InterPro:IPR025962" /db_xref="InterPro:IPR026272" /db_xref="SubtiList:BG14077" /db_xref="UniProtKB/Swiss-Prot:O32241" /translation="MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSK PLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGY EVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLV VCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR*" gene complement(3148262..3148885) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" downshifts complement(3148270) /Source="Nicolas_upshifts" /id="D1756" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="6.43517" /MaxDrop="3.3455" /score="8.72167152" /energy="-11.6" /TU="U2665,U2667" /idTUdmin="U2667" /TUdmin="-22" /isTUend="TRUE" CDS complement(3148882..3149154) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 17069462, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of SdpC synthesis operon (ArsR family)" /protein_id="NP_391259.1" /db_xref="EnsemblGenomes-Gn:BSU33790" /db_xref="EnsemblGenomes-Tr:CAB15384" /db_xref="GOA:O32242" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14078" /db_xref="UniProtKB/Swiss-Prot:O32242" /translation="MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHH LNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL*" gene complement(3148882..3149154) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" promotor_-10 complement(3149210..3149229) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3149219) /Source="Nicolas_upshifts" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" S_feature complement(3149221..3149369) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" promotor_-35 complement(3149241..3149247) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3149374..3150063) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" gene complement(3149374..3150063) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" downshifts complement(3149414) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" promotor_-35 3150006..3150014 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3150028..3150047 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3150042 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3150081..3150992) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" gene complement(3150081..3150992) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" CDS complement(3151012..3151665) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " gene complement(3151012..3151665) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" CDS complement(3151688..3152830) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" gene complement(3151688..3152830) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" promotor_-10 complement(3152874..3152893) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(3152889) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" promotor_-35 complement(3152908..3152911) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 3153027..3153034 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3153047..3153066 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3153058 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" CDS 3153094..3153651 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" gene 3153094..3153651 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" S_feature 3153652..3154416 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(3153669..3154304) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" gene complement(3153669..3154304) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" downshifts complement(3153682) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3154345..3154363) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3154351) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" promotor_-35 complement(3154379..3154385) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3154390..3154397 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3154409..3154428 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3154418 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" CDS 3154454..3155068 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" gene 3154454..3155068 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" downshifts 3155054 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" promotor_-35 3155122..3155125 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3155140..3155159 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3155148 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" CDS 3155200..3155898 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" gene 3155200..3155898 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" downshifts 3155871 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" CDS complement(3155934..3157751) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" gene complement(3155934..3157751) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" downshifts complement(3155953) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" downshifts complement(3156124) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" misc_feature complement(3157793..3157812) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 3157797..3157816 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3157802 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" upshifts complement(3157806) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" CDS 3157871..3158338 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" gene 3157871..3158338 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" downshifts 3158335 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" CDS complement(3158383..3159675) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" gene complement(3158383..3159675) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" downshifts complement(3158393) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" CDS complement(3159705..3161240) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" gene complement(3159705..3161240) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" CDS complement(3161233..3161994) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" gene complement(3161233..3161994) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" CDS complement(3162025..3163209) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" gene complement(3162025..3163209) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" S_feature complement(3163210..3163450) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(3163450) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" S_feature complement(3163452..3163525) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(3163464..3163483) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3163499..3163503) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3163526..3164533) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" gene complement(3163526..3164533) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" promotor_-35 3164452..3164455 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3164472..3164474 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3164474 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3164580..3165602) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" gene complement(3164580..3165602) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" upshifts complement(3164596) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" promotor_-10 complement(3164604) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3164624..3164625) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3165603..3165714) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 3165640 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" promotor_-10 complement(3165695..3165714) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3165714) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" S_feature complement(3165716..3165826) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(3165728..3165735) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3165809..3165828) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(3165824) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" promotor_-35 complement(3165841..3165850) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(3165900..3167294) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" gene complement(3165900..3167294) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" downshifts complement(3165914) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3167393..3167412) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3167407) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" promotor_-35 complement(3167427..3167434) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3167434..3167441 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3167455..3167474 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3167461 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" CDS 3167498..3168586 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" gene 3167498..3168586 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" downshifts 3168566 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" CDS complement(3168635..3169645) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" gene complement(3168635..3169645) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" downshifts complement(3168642) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" S_feature complement(3169646..3169723) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3169713..3169732) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3169723) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" promotor_-35 complement(3169746..3169753) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3169802..3170680) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" gene complement(3169802..3170680) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" promotor_-35 3170338..3170344 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3170359..3170370 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3170370 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3170714..3170721 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3170727..3170746) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3170732) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" promotor_-10 3170735..3170754 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3170737 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" promotor_-35 complement(3170760..3170764) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3170780..3171697 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" gene 3170780..3171697 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" downshifts 3171686 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" CDS complement(3171738..3173081) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" gene complement(3171738..3173081) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" misc_RNA complement(3173150..3173385) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" gene complement(3173150..3173385) /gene="tboX" /locus_tag="BSU_misc_RNA_56" downshifts complement(3173284) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3173386..3173482) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3173483..3174517) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" gene complement(3173483..3174517) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" promotor_-10 complement(3174539..3174557) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3174545) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" promotor_-35 complement(3174570..3174577) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3174625..3175347) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" gene complement(3174625..3175347) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" downshifts complement(3174641) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" CDS complement(3175347..3176786) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" gene complement(3175347..3176786) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" promotor_-35 3176334..3176337 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3176354 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3176355..3176359 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3176508 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" upshifts 3176662 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3176663..3176664 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3176813..3177529) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" gene complement(3176813..3177529) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" promotor_-35 3177433..3177440 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3177454..3177456 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3177454 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3177527 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" S_feature complement(3177530..3177596) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3177593..3177612) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3177596) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" promotor_-35 complement(3177627..3177634) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3177704..3178306) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" gene complement(3177704..3178306) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" CDS complement(3178323..3179438) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" gene complement(3178323..3179438) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" CDS complement(3179442..3180179) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" gene complement(3179442..3180179) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" promotor_-10 complement(3179468..3179487) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3179482) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" promotor_-35 complement(3179499..3179506) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3180180..3181085) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" gene complement(3180180..3181085) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" promotor_-10 complement(3181105..3181123) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3181116) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3181139..3181142) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3181294..3181301 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3181312..3181331 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3181319 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" CDS 3181369..3182178 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" gene 3181369..3182178 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" CDS 3182214..3183425 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" gene 3182214..3183425 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" downshifts 3183412 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" CDS complement(3183479..3184768) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" gene complement(3183479..3184768) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" CDS complement(3184848..3186911) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" gene complement(3184848..3186911) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" CDS complement(3186930..3187781) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" gene complement(3186930..3187781) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" CDS complement(3187785..3189041) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" gene complement(3187785..3189041) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" CDS complement(3189081..3190346) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" gene complement(3189081..3190346) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" promotor_-10 complement(3190378..3190397) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3190400) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" promotor_-35 complement(3190412..3190419) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3190487..3191479) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" gene complement(3190487..3191479) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" downshifts complement(3190521) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" S_feature complement(3191609..3191658) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3191632) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" CDS complement(3191659..3192318) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" gene complement(3191659..3192318) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" S_feature complement(3192319..3192424) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3192416..3192435) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3192425) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" promotor_-35 complement(3192450..3192453) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3192477..3192484 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3192499..3192518 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3192499 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" S_feature 3192502..3192607 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3192508..3192525) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3192512) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3192533..3192539) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3192608..3194299 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" gene 3192608..3194299 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" downshifts 3194284 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" CDS complement(3194326..3195636) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" gene complement(3194326..3195636) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" S_feature 3194329..3195399 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3194338) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" misc_feature 3195456..3195475 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3195456..3195714 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3195456 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" promotor_-10 complement(3195650..3195669) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3195665) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" promotor_-35 complement(3195684..3195687) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3195715..3195933 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" gene 3195715..3195933 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" downshifts 3195912 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" CDS complement(3195943..3196911) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" gene complement(3195943..3196911) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" CDS complement(3196890..3198056) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" gene complement(3196890..3198056) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" CDS complement(3198061..3198711) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" gene complement(3198061..3198711) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" CDS complement(3198708..3199316) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" gene complement(3198708..3199316) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" CDS complement(3199313..3200830) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" gene complement(3199313..3200830) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" CDS complement(3200827..3201861) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" gene complement(3200827..3201861) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" CDS complement(3201858..3202934) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" gene complement(3201858..3202934) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" CDS complement(3202939..3203973) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" gene complement(3202939..3203973) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" CDS complement(3203998..3205101) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" gene complement(3203998..3205101) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" CDS complement(3205098..3206252) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" gene complement(3205098..3206252) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" CDS complement(3206245..3207081) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" gene complement(3206245..3207081) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" CDS complement(3207078..3208223) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" gene complement(3207078..3208223) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" CDS complement(3208235..3210031) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" gene complement(3208235..3210031) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" S_feature complement(3210032..3210091) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3210065..3210083) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3210091) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" promotor_-35 complement(3210097..3210103) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3210290..3210973) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" gene complement(3210290..3210973) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" CDS complement(3210979..3211683) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" gene complement(3210979..3211683) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" promotor_-35 3211648 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3211665 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" promotor_-10 3211668..3211686 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3211684..3211741) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3211737..3211756) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3211742) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" promotor_-35 complement(3211770..3211777) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3211859..3211864 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3211879..3211898 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3211885 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" CDS 3211929..3212387 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" gene 3211929..3212387 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" promotor_-35 3212409..3212412 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3212418 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" promotor_-10 3212429..3212447 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3212463..3213932 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" gene 3212463..3213932 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" downshifts 3213909 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" CDS 3213935..3214126 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" gene 3213935..3214126 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" downshifts 3214105 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" CDS complement(3214153..3214638) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" gene complement(3214153..3214638) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" CDS complement(3214661..3214972) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" gene complement(3214661..3214972) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo CDS complement(3215024..3215116) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" gene complement(3215024..3215116) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo promotor_-10 complement(3215156..3215175) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3215173) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" promotor_-35 complement(3215189..3215196) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3215247..3215930) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" gene complement(3215247..3215930) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" downshifts complement(3215265) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" CDS complement(3215946..3217301) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" gene complement(3215946..3217301) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" promotor_-10 complement(3217313..3217328) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3217329) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" promotor_-35 complement(3217340..3217349) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3217603..3217610 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3217624..3217643 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3217627 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" S_feature 3217649..3217839 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3217840..3219261 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" gene 3217840..3219261 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" downshifts 3219255 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" CDS 3219335..3220885 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" gene 3219335..3220885 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" promotor_-35 3220929..3220935 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3220949..3220960 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3220949 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" CDS 3220993..3222555 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" gene 3220993..3222555 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" downshifts 3222533 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" CDS 3222545..3223234 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" gene 3222545..3223234 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" promotor_-35 3222584..3222591 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3222605..3222624 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3222614 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" downshifts 3223215 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" downshifts complement(3223313) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" CDS 3223316..3223651 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" gene 3223316..3223651 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" CDS 3223651..3223971 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" gene 3223651..3223971 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" S_feature 3223972..3224162 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3224007..3224519) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" gene complement(3224007..3224519) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" downshifts 3224139 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3224555..3224566) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3224561) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" promotor_-35 complement(3224581..3224587) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3224634..3224770) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3224677) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" CDS complement(3224771..3226114) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" gene complement(3224771..3226114) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" promotor_-10 complement(3226143..3226162) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3226151) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" promotor_-35 complement(3226175..3226184) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3226176..3226181 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3226197..3226215 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3226200 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3226409..3226418 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3226427 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" promotor_-10 3226432..3226451 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3226470..3227432 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" gene 3226470..3227432 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" S_feature 3227433..3227686 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3227713) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" tRNA complement(3227717..3227792) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3227717..3227792) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" promotor_-10 complement(3227819..3227838) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3227840) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" promotor_-35 complement(3227854..3227857) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3227923..3227929 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3227939..3228014 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3227939 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" promotor_-10 3227944..3227963 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3227991..3227998 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3228012..3228031 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3228016 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" CDS 3228062..3228655 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" gene 3228062..3228655 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" downshifts 3228644 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" S_feature 3228689..3229087 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3228701..3229381) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" gene complement(3228701..3229381) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" downshifts complement(3228725) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" CDS complement(3229378..3231063) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" gene complement(3229378..3231063) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" CDS complement(3231056..3233329) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" gene complement(3231056..3233329) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" CDS complement(3233307..3234191) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" gene complement(3233307..3234191) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" CDS complement(3234197..3235033) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" gene complement(3234197..3235033) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" CDS complement(3235034..3236341) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" gene complement(3235034..3236341) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" promotor_-35 3235399..3235408 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3235421..3235440 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3235425 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3236381..3237634) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" gene complement(3236381..3237634) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" S_feature complement(3237635..3237729) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3237730..3239499) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" gene complement(3237730..3239499) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" promotor_-35 3239420..3239425 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3239441..3239459 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3239451 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3239537..3239556) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3239550) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" promotor_-35 complement(3239569..3239576) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3239612..3240562) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" gene complement(3239612..3240562) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" promotor_-10 complement(3240577..3240595) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3240590) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3240607..3240615) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3240696) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" CDS complement(3240768..3241343) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" gene complement(3240768..3241343) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" downshifts complement(3240780) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" promotor_-10 complement(3241386..3241405) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3241392..3241399 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3241402) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" upshifts 3241409 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" promotor_-10 3241412..3241431 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3241420..3241427) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3241460..3241780 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" gene 3241460..3241780 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" downshifts 3241761 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" downshifts complement(3241807) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" CDS complement(3241807..3243399) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" gene complement(3241807..3243399) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" CDS complement(3243418..3244011) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" gene complement(3243418..3244011) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" promotor_-10 complement(3244053..3244072) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3244066) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" promotor_-35 complement(3244087..3244091) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3244137..3244142 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3244158..3244176 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3244159 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" promotor_-35 3244332..3244339 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3244353..3244372 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3244357 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" CDS 3244394..3245371 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" gene 3244394..3245371 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" downshifts 3245343 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" CDS complement(3245409..3247349) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" gene complement(3245409..3247349) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" downshifts complement(3245433) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" CDS complement(3247324..3248103) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" gene complement(3247324..3248103) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" S_feature complement(3248104..3248185) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3248186..3249256) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" gene complement(3248186..3249256) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" CDS complement(3249250..3249963) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" gene complement(3249250..3249963) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" promotor_-10 complement(3250009..3250028) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3250021) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" S_feature complement(3250023..3250284) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3250041..3250044) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3250044..3250051 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3250062..3250081 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3250067 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" CDS 3250110..3250319 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" gene 3250110..3250319 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" downshifts 3250297 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" downshifts complement(3250329) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" CDS complement(3250355..3251119) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" gene complement(3250355..3251119) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" downshifts complement(3250377) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" CDS complement(3251120..3251377) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" gene complement(3251120..3251377) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" CDS complement(3251401..3252351) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" gene complement(3251401..3252351) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" CDS complement(3252374..3253327) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" gene complement(3252374..3253327) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" CDS complement(3253329..3254216) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" gene complement(3253329..3254216) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" CDS complement(3254241..3254717) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" gene complement(3254241..3254717) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" promotor_-10 complement(3254737..3254756) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3254751) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" promotor_-35 complement(3254772..3254776) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3254795..3254814) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3254808) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" promotor_-35 complement(3254829..3254832) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3254884..3255034) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3254927) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" CDS complement(3255035..3255985) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" gene complement(3255035..3255985) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" S_feature complement(3255986..3256073) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3256062..3256081) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3256073) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" S_feature complement(3256075..3256166) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3256096..3256099) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3256114..3256120 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3256134..3256152 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3256148 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" S_feature 3256149..3259535 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3256191..3257612) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" gene complement(3256191..3257612) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" downshifts complement(3256211) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" downshifts complement(3256335) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" misc_feature 3257239..3257243 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3257249 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3257528..3257532 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3257535 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3257613..3257810) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3257733 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" promotor_-10 complement(3257798..3257817) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3257810) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" promotor_-35 complement(3257829..3257836) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3257993..3259447) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" gene complement(3257993..3259447) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" downshifts complement(3258013) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" S_feature complement(3259448..3259572) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3259493 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" CDS complement(3259573..3261342) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" gene complement(3259573..3261342) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" S_feature complement(3261343..3261417) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3261406..3261425) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3261417) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" CDS complement(3261507..3261866) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" gene complement(3261507..3261866) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" downshifts complement(3261527) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" CDS complement(3261881..3263791) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" gene complement(3261881..3263791) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" CDS complement(3263793..3264518) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" gene complement(3263793..3264518) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" S_feature complement(3264519..3264607) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3264607..3264626) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3264607) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" S_feature complement(3264609..3264738) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3264642..3264645) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3264764..3265393) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" gene complement(3264764..3265393) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" downshifts complement(3264783) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" CDS complement(3265390..3266148) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" gene complement(3265390..3266148) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" CDS complement(3266145..3266882) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" gene complement(3266145..3266882) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" CDS complement(3266879..3267517) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" gene complement(3266879..3267517) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" promotor_no_box 3267375..3267475 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3267435 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3267518..3268102) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" gene complement(3267518..3268102) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" CDS complement(3268099..3269382) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" gene complement(3268099..3269382) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" CDS complement(3269379..3270020) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" gene complement(3269379..3270020) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" CDS complement(3270013..3271188) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " gene complement(3270013..3271188) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" S_feature complement(3271189..3271266) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3271232..3271238 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3271250..3271269 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3271250..3271269) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3271263 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3271266) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" promotor_-35 complement(3271282..3271289) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3271398..3271417 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3271405 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" CDS 3271439..3272191 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" gene 3271439..3272191 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" S_feature 3272192..3272430 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3272213..3272224) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272219) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3272239..3272245) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3272431..3273096 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" gene 3272431..3273096 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" downshifts 3273067 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" CDS complement(3273116..3273634) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" gene complement(3273116..3273634) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" downshifts complement(3273150) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" CDS complement(3273638..3274288) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" gene complement(3273638..3274288) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" CDS complement(3274285..3275223) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" gene complement(3274285..3275223) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" CDS complement(3275247..3276056) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" gene complement(3275247..3276056) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" CDS complement(3276070..3277002) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" gene complement(3276070..3277002) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" promotor_-10 complement(3277044..3277063) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3277050) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" promotor_-35 complement(3277079..3277084) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3277119..3277126 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3277138 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" promotor_-10 3277141..3277158 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3277184..3278374 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" gene 3277184..3278374 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" promotor_-35 3278172..3278178 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3278193 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" promotor_-10 3278194..3278212 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3278371..3279099 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" gene 3278371..3279099 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" CDS 3279117..3279848 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" gene 3279117..3279848 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" CDS complement(3279868..3283737) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" gene complement(3279868..3283737) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" downshifts complement(3279990) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(3283757..3283768) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283764) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" promotor_-35 complement(3283783..3283789) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3283827..3283833 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3283847..3283866 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3283852 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" CDS 3283902..3284375 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" gene 3283902..3284375 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" S_feature 3284376..3284483 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3284416..3285633) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" gene complement(3284416..3285633) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" downshifts complement(3284429) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" promotor_-35 3284455..3284460 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3284475..3284486 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3284485..3284770 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3284485 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" downshifts 3284727 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" CDS complement(3285649..3286395) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" gene complement(3285649..3286395) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" S_feature complement(3286396..3286582) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3286568..3286587) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3286582) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" promotor_-35 complement(3286601..3286608) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3286716..3286723 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3286738..3286757 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3286750 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" S_feature 3286751..3286820 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3286821..3287330 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" gene 3286821..3287330 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" S_feature complement(3287226..3288564) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3287267) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" CDS 3287351..3288562 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" gene 3287351..3288562 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" downshifts 3288560 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" CDS complement(3288590..3288949) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" gene complement(3288590..3288949) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" S_feature 3288605..3289321 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3288609) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" CDS complement(3288951..3289148) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" gene complement(3288951..3289148) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" CDS complement(3289153..3290250) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" gene complement(3289153..3290250) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" CDS complement(3290275..3290601) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" gene complement(3290275..3290601) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" promotor_-10 complement(3290654..3290669) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3290669) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" S_feature complement(3290671..3291161) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3290681..3290690) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3290749..3290752 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3290767..3290786 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3290777 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" CDS 3290819..3291049 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" gene 3290819..3291049 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" promotor_-10 complement(3291152..3291171) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3291162) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" promotor_-35 complement(3291187..3291191) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3291248..3291730) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" gene complement(3291248..3291730) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo downshifts 3291256 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" downshifts complement(3291271) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" upshifts complement(3291403) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3291411..3291414) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3291491..3291495) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3291491) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3291511..3291514) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3291731..3291864) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3291892..3294765) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" gene complement(3291892..3294765) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" downshifts complement(3291909) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" CDS complement(3294773..3296758) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" gene complement(3294773..3296758) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" promotor_-10 complement(3296792..3296811) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3296804) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" S_feature complement(3296806..3296891) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3296823..3296830) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3296936) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" CDS complement(3296944..3297174) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" gene complement(3296944..3297174) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" promotor_-10 complement(3297201..3297220) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3297211) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" S_feature complement(3297213..3297277) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3297234..3297241) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3297254..3297272) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3297275) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" promotor_-35 complement(3297287..3297293) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3297343) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" promotor_no_box complement(3297369..3297469) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3297409) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3297491..3297498 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3297512..3297531 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3297529 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3297621..3300116 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" gene 3297621..3300116 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" misc_feature 3300131..3300135 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3300149 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" CDS 3300192..3300761 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" gene 3300192..3300761 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" CDS 3300792..3302126 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" gene 3300792..3302126 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" downshifts 3302107 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" CDS complement(3302174..3303367) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" gene complement(3302174..3303367) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" downshifts complement(3302183) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" downshifts complement(3302248) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" S_feature complement(3303368..3303445) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3303371) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" CDS complement(3303446..3303784) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" gene complement(3303446..3303784) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo CDS complement(3303759..3303875) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" gene complement(3303759..3303875) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo S_feature complement(3303876..3303965) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3303947..3303965) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3303965) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" S_feature complement(3303967..3304047) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3303979..3303984) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3304033..3304051) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3304047) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" promotor_-35 complement(3304065..3304072) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3304184..3305626) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" gene complement(3304184..3305626) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" downshifts complement(3304273) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" promotor_-10 complement(3305672..3305683) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3305683) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" promotor_-35 complement(3305698..3305704) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3305766..3306656) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" gene complement(3305766..3306656) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" downshifts complement(3305783) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" CDS complement(3306649..3307335) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" gene complement(3306649..3307335) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" S_feature complement(3307336..3307468) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3307458..3307477) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3307468) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" promotor_-35 complement(3307492..3307495) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3307569..3307907) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" gene complement(3307569..3307907) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" downshifts complement(3307570) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(3307934..3307953) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3307947) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" CDS complement(3307956..3308840) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" gene complement(3307956..3308840) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" promotor_-35 complement(3307967..3307974) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3308828..3308847) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3308849) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" promotor_-35 complement(3308862..3308869) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3309997..3310068), complement(3308967..3309995)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" gene complement(3308967..3310068) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" downshifts complement(3308983) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" S_feature complement(3310069..3310137) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3310138..3312663) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" gene complement(3310138..3312663) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" S_feature complement(3312664..3312744) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3312734..3312753) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3312744) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" CDS complement(3312831..3313400) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" gene complement(3312831..3313400) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" downshifts complement(3312839) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" promotor_-35 3313367..3313373 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3313386..3313405 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3313393 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3313427..3313445) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3313435) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" S_feature complement(3313437..3313557) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3313457..3313465) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3313541..3313559) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3313557) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" promotor_-35 complement(3313575..3313580) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3313591..3313968) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" gene complement(3313591..3313968) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" CDS complement(3313978..3314319) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" gene complement(3313978..3314319) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" CDS complement(3314316..3314717) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" gene complement(3314316..3314717) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" CDS complement(3314739..3316235) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" gene complement(3314739..3316235) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" CDS complement(3316253..3316582) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" gene complement(3316253..3316582) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" downshifts 3316579 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" promotor_-10 complement(3316604..3316622) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3316619) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" S_feature complement(3316621..3316725) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3316636..3316643) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3316714..3316733) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3316725) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" CDS complement(3316815..3317729) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" gene complement(3316815..3317729) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" downshifts complement(3316835) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" S_feature complement(3317730..3317838) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3317796..3317797 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3317806..3317820 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3317815 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3317817..3317835) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3317838) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" promotor_-35 complement(3317848..3317855) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3317874..3318098) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" gene complement(3317874..3318098) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" downshifts complement(3317913) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" CDS complement(3318092..3318523) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" gene complement(3318092..3318523) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" CDS complement(3318544..3319119) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" gene complement(3318544..3319119) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" CDS complement(3319166..3320062) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" gene complement(3319166..3320062) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" downshifts complement(3319189) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" misc_feature 3319478..3319481 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3319487 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3320073..3321596) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " gene complement(3320073..3321596) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" CDS complement(3321615..3322097) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" gene complement(3321615..3322097) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" CDS complement(3322113..3322379) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" gene complement(3322113..3322379) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" S_feature complement(3322380..3322459) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3322460..3322879) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" gene complement(3322460..3322879) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" promotor_-10 complement(3322918..3322936) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3322929) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3322950..3322957) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3322953..3323675) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" gene complement(3322953..3323675) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" CDS complement(3323639..3323935) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" gene complement(3323639..3323935) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" promotor_-10 complement(3323961..3323980) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3323974) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3323991..3323998) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3323995..3325386) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" gene complement(3323995..3325386) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" promotor_-10 complement(3325400..3325419) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3325415) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3325433..3325440) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3325492..3326337) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" gene complement(3325492..3326337) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" downshifts complement(3325503) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" promotor_-35 3325754..3325761 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3325775..3325794 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3325785..3327517 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3325785 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" promotor_-10 complement(3326364..3326383) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3326383) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" promotor_-35 complement(3326398..3326401) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3326435..3327124) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" gene complement(3326435..3327124) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" downshifts complement(3326449) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" S_feature complement(3327125..3327206) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3327207..3328364) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" gene complement(3327207..3328364) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" S_feature complement(3328365..3328492) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3328412..3328415 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3328430..3328449 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3328441..3328527 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3328441 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" promotor_-10 complement(3328486..3328505) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3328492) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" promotor_-35 3328509..3328517 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3328516..3328523) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3328529 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" promotor_-10 3328531..3328539 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3328581..3329234 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " gene 3328581..3329234 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" S_feature complement(3328937..3329529) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3329234..3330409 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " gene 3329234..3330409 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" promotor_-10 complement(3329525..3329543) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3329534) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" promotor_-35 complement(3329557..3329563) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3330381 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" CDS complement(3330482..3331558) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" gene complement(3330482..3331558) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" downshifts complement(3330498) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3330544..3330553 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3330567..3330586 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3330575..3331808 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3330575 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" S_feature complement(3331559..3331641) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3331629..3331648) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3331641) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" promotor_-35 complement(3331660..3331666) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3331703..3332896) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" gene complement(3331703..3332896) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" downshifts complement(3331733) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" CDS complement(3332925..3333683) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" gene complement(3332925..3333683) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" CDS complement(3333707..3334387) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" gene complement(3333707..3334387) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" CDS complement(3334416..3335882) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" gene complement(3334416..3335882) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" S_feature complement(3335883..3335966) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3335967..3337352) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" gene complement(3335967..3337352) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" CDS complement(3337414..3338583) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" gene complement(3337414..3338583) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" CDS complement(3338580..3340031) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" gene complement(3338580..3340031) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" CDS complement(3340087..3340236) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" gene complement(3340087..3340236) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo CDS complement(3340181..3340720) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" gene complement(3340181..3340720) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo misc_feature complement(3340776..3340793) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3340780) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" CDS complement(3340947..3342437) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" gene complement(3340947..3342437) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" downshifts complement(3340969) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" CDS complement(3342476..3344593) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" gene complement(3342476..3344593) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" CDS complement(3344617..3344925) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" gene complement(3344617..3344925) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" downshifts 3344831 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" promotor_-35 3344921..3344925 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3344934..3344948 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3344935..3344953) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3344941 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3344967..3344974) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3344970) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" promotor_-35 3344991..3344999 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3345013..3345026 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3345031 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" CDS 3345109..3346029 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" gene 3345109..3346029 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" downshifts 3346019 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" CDS complement(3346069..3347211) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" gene complement(3346069..3347211) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" downshifts complement(3346093) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(3347250..3347269) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3347264) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" promotor_-35 complement(3347284..3347287) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3347340..3347344 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3347360..3347379 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3347361..3347456 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3347362 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" CDS 3347457..3348335 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" gene 3347457..3348335 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" S_feature 3348336..3349427 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3348405..3348760) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3348669..3348887 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" gene 3348669..3348887 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" CDS complement(3348761..3348844) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" gene complement(3348761..3348844) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo S_feature complement(3348845..3349036) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3349037..3351739) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" gene complement(3349037..3351739) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" S_feature complement(3351740..3351862) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3351761..3351767 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3351782..3351800 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3351787..3354619 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3351787 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" CDS complement(3351863..3353203) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" gene complement(3351863..3353203) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo CDS complement(3353244..3353450) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" gene complement(3353244..3353450) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo S_feature complement(3353451..3354324) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3354318..3354337) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3354324) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" S_feature complement(3354326..3354565) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3354350..3354356) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3354547..3354565) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3354565) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" promotor_-35 complement(3354579..3354586) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3354588..3354595 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3354607..3354626 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3354621..3354751 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3354621 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" promotor_no_box 3354693..3354793 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3354753 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" CDS 3354757..3355353 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" gene 3354757..3355353 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo downshifts 3354951 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" CDS complement(3355392..3356975) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" gene complement(3355392..3356975) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" downshifts 3355435 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" CDS complement(3356995..3357822) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " gene complement(3356995..3357822) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" S_feature complement(3357823..3357887) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3357883..3357902) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3357887) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" S_feature complement(3357889..3357986) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3357918..3357921) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3357987..3360227) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" gene complement(3357987..3360227) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" CDS complement(3360227..3362248) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" gene complement(3360227..3362248) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" promotor_-35 3360990..3360999 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3361012..3361027 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3361023 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3362249..3362408) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3362409..3362798) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" gene complement(3362409..3362798) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" S_feature complement(3362799..3362933) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3362917..3362936) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3362933) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" promotor_-35 complement(3362947..3362954) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3363088..3363094 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3363105..3363197 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3363105 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" promotor_-10 3363106..3363125 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3363198..3363968 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" gene 3363198..3363968 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" S_feature complement(3363325..3363673) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3363677..3363688) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3363681) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" promotor_-35 complement(3363703..3363709) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3363993 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" CDS 3364001..3365146 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" gene 3364001..3365146 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" downshifts 3365134 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" promotor_-35 3365188..3365195 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3365210..3365229 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3365220 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" CDS 3365266..3366594 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" gene 3365266..3366594 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" downshifts 3366589 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" downshifts complement(3366650) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" CDS complement(3366654..3369296) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" gene complement(3366654..3369296) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" promotor_-10 complement(3367899..3367918) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367901) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3367931..3367940) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3369331..3369349) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369336) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" promotor_-35 complement(3369363..3369370) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3369425..3370375) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" gene complement(3369425..3370375) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" downshifts complement(3369437) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3370400..3370418) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3370405) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" S_feature complement(3370407..3370543) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3370433..3370439) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3370517..3370536) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3370545) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" promotor_-35 3370573..3370579 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3370593..3370604 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3370593 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" CDS 3370640..3372091 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" gene 3370640..3372091 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" CDS 3372097..3373203 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" gene 3372097..3373203 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" CDS 3373200..3374324 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" gene 3373200..3374324 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" S_feature complement(3373427..3374321) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3374314 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" CDS complement(3374361..3375734) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" gene complement(3374361..3375734) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" downshifts complement(3374366) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" S_feature complement(3375735..3375798) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3375786..3375804) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3375799) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" promotor_-35 complement(3375819..3375825) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3375885..3375894 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3375906..3375921 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3375908..3376028 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3375908 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" promotor_-35 3376003..3376010 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3376024..3376043 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3376030 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" CDS 3376067..3377035 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" gene 3376067..3377035 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" downshifts 3377020 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" promotor_-35 3377079..3377086 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3377101..3377120 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3377108..3377190 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3377108 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" CDS 3377191..3378051 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" gene 3377191..3378051 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" downshifts 3378032 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" CDS complement(3378085..3379326) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" gene complement(3378085..3379326) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" downshifts complement(3378104) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" promotor_-10 complement(3379348..3379366) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3379370) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" promotor_-35 complement(3379379..3379386) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3379467..3379634) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" gene complement(3379467..3379634) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" downshifts complement(3379494) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" CDS complement(3379649..3380791) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" gene complement(3379649..3380791) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" CDS complement(3380810..3381259) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" gene complement(3380810..3381259) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" promotor_-35 3380953..3380959 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3380967 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" promotor_-10 3380973..3380991 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3380980..3383189 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3381274..3382455) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" gene complement(3381274..3382455) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" promotor_-35 3383169..3383176 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3383191 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" promotor_-10 3383192..3383211 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3383212) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3383217..3383231) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3383239..3383243) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3383239..3384219 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" gene 3383239..3384219 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" promotor_-35 3384068..3384075 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3384089..3384108 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3384104 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" CDS 3384221..3385102 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" gene 3384221..3385102 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" CDS 3385099..3385494 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" gene 3385099..3385494 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" CDS 3385510..3386991 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" gene 3385510..3386991 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" CDS 3386993..3387961 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" gene 3386993..3387961 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" CDS 3387973..3388890 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" gene 3387973..3388890 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" promotor_-35 3388899..3388905 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3388920..3388938 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3388922 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" CDS 3388972..3389508 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" gene 3388972..3389508 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" downshifts 3389491 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" S_feature 3389536..3389646 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3389615..3389621 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3389636..3389647 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3389648 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" CDS 3389664..3389960 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" gene 3389664..3389960 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" S_feature 3389961..3390613 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3390000..3390527) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" gene complement(3390000..3390527) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" downshifts complement(3390010) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3390547..3390566) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3390560) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" downshifts 3390571 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" promotor_-35 complement(3390580..3390587) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3390626) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" CDS complement(3390627..3391394) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" gene complement(3390627..3391394) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" CDS complement(3391456..3393168) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" gene complement(3391456..3393168) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" promotor_-35 3392067..3392076 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3392090..3392109 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3392090 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3393222..3393241) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393227) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" promotor_-35 3393247..3393254 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3393256..3393260) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3393268..3393287 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3393278 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" CDS 3393326..3394234 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" gene 3393326..3394234 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" promotor_-35 3394302..3394310 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3394312..3394444 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3394312 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" promotor_-10 3394324..3394343 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3394445..3395773 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" gene 3394445..3395773 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" downshifts 3395764 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" CDS complement(3395830..3396507) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" gene complement(3395830..3396507) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" downshifts complement(3395840) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" CDS complement(3396567..3397709) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" gene complement(3396567..3397709) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" promotor_-10 complement(3397746..3397765) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3397754) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" S_feature complement(3397756..3397836) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3397779..3397787) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3397837..3398925) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" gene complement(3397837..3398925) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" S_feature complement(3398926..3399039) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3398981..3398990 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3399003..3399022 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3399016 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" upshifts complement(3399039) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" promotor_-10 complement(3399043..3399057) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3399066..3399070) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3399066..3399653 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" gene 3399066..3399653 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" CDS 3399154..3399633 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " gene 3399154..3399633 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" S_feature complement(3399537..3399734) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3399570 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" downshifts complement(3399580) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" downshifts 3399639 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" downshifts 3399718 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(3399733..3399752) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399739) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" promotor_-35 3399761..3399768 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3399765..3399774) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3399783..3399802 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3399789 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" CDS 3399827..3400444 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" gene 3399827..3400444 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" S_feature 3400445..3400545 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3400502 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" promotor_-35 3400571..3400580 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3400592..3400607 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3400593 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" CDS 3400622..3400957 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" gene 3400622..3400957 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" promotor_-10 complement(3400913..3400931) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3400922) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3400946..3400951) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3400956 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" CDS complement(3400962..3402539) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" gene complement(3400962..3402539) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" S_feature 3401001..3402712 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3402690..3402697 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3402708..3402727 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3402714 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" CDS 3402753..3403229 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" gene 3402753..3403229 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" CDS 3403243..3403836 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" gene 3403243..3403836 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" CDS 3403833..3404369 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" gene 3403833..3404369 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" downshifts 3404350 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" CDS complement(3404396..3404617) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" gene complement(3404396..3404617) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" upshifts 3404564 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3404571..3404572 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3404614..3405159) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" gene complement(3404614..3405159) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" promotor_-35 3405176..3405183 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3405198..3405217 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3405202 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" CDS 3405282..3406163 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" gene 3405282..3406163 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" CDS complement(3406248..3406964) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" gene complement(3406248..3406964) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" downshifts complement(3406268) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" CDS complement(3406974..3407438) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" gene complement(3406974..3407438) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" CDS complement(3407428..3409236) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" gene complement(3407428..3409236) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" CDS complement(3409255..3409515) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" gene complement(3409255..3409515) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" CDS complement(3409525..3409947) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" gene complement(3409525..3409947) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" S_feature complement(3409948..3410030) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3410022..3410041) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3410030) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" promotor_-35 complement(3410054..3410061) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3410164..3410289) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" gene complement(3410164..3410289) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" S_feature complement(3410207..3410338) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3410250) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" CDS complement(3410339..3411124) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" gene complement(3410339..3411124) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" S_feature complement(3411125..3411240) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3411233..3411252) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3411240) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" promotor_-35 complement(3411266..3411273) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3411316..3412638) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" gene complement(3411316..3412638) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" downshifts complement(3411328) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" upshifts complement(3412672) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" S_feature complement(3412674..3412799) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3412674..3412692) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3412708..3412713) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3412779..3412798) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3412799) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" CDS complement(3412833..3413597) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" gene complement(3412833..3413597) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" downshifts complement(3413616) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" CDS complement(3413650..3414363) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" gene complement(3413650..3414363) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" downshifts complement(3413667) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" CDS complement(3414353..3415099) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" gene complement(3414353..3415099) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" promotor_-10 complement(3415131..3415150) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3415143) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" promotor_-35 complement(3415167..3415170) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3415333..3415476) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" gene complement(3415333..3415476) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" downshifts complement(3415354) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" S_feature complement(3415477..3415562) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3415552..3415563) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3415562) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" S_feature complement(3415564..3415794) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3415601..3415605 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3415621..3415640 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3415630 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" CDS 3415680..3417290 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" gene 3415680..3417290 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" promotor_-10 complement(3415782..3415800) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3415794) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" S_feature complement(3415796..3415970) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3415814..3415821) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3415957..3415976) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3415970) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" promotor_-35 complement(3415990..3415998) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3417277..3420045 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" gene 3417277..3420045 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" downshifts complement(3420094) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" CDS complement(3420171..3421028) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" gene complement(3420171..3421028) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" CDS complement(3421034..3421810) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" gene complement(3421034..3421810) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" promotor_-10 complement(3421836..3421855) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3421858) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" S_feature complement(3421860..3421932) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3421870..3421877) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3421934..3422033) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3421977) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" CDS complement(3422034..3422375) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" gene complement(3422034..3422375) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" promotor_-10 complement(3422397..3422416) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3422416) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" promotor_-35 complement(3422430..3422437) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3422452..3422835) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" gene complement(3422452..3422835) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" promotor_-10 complement(3422857..3422876) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3422864..3422883 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3422868 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3422877) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" promotor_-35 complement(3422891..3422898) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3422958..3422977 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3422961 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" downshifts complement(3423010) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" CDS 3423010..3423420 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" gene 3423010..3423420 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" S_feature 3423421..3423504 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3423462 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" CDS complement(3423560..3423868) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" gene complement(3423560..3423868) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" downshifts complement(3423561) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" CDS 3424212..3425048 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" gene 3424212..3425048 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" promotor_-35 3424428..3424435 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3424450..3424469 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3424453 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3425047 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" CDS complement(3425095..3425487) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" gene complement(3425095..3425487) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" downshifts complement(3425101) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" CDS complement(3425560..3425985) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" gene complement(3425560..3425985) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" promotor_-10 complement(3426046..3426065) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3426062) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" S_feature complement(3426064..3426148) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3426080..3426087) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3426127 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" misc_feature 3426130..3426149 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3426140..3426159) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3426148) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" S_feature complement(3426150..3427234) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3426173..3426178) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3426177..3427241 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" gene 3426177..3427241 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" S_feature 3427242..3428126 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3427264..3428073) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" gene complement(3427264..3428073) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" downshifts complement(3427279) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" CDS complement(3428107..3428919) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" gene complement(3428107..3428919) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" S_feature complement(3428920..3428999) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3428950..3428957 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3428971..3428990 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3428980 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3428993..3429011) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3428999) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" promotor_-35 complement(3429025..3429032) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3429082..3430083) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " gene complement(3429082..3430083) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" downshifts complement(3429088) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" misc_feature complement(3430138..3430157) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3430162) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" S_feature complement(3430164..3430248) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3430249..3430530) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" gene complement(3430249..3430530) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" CDS complement(3430545..3430655) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" gene complement(3430545..3430655) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" promotor_-10 complement(3430686..3430704) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3430708) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" promotor_-35 complement(3430720..3430725) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3430801..3430807 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3430821..3430840 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3430837 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" CDS 3430880..3431293 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" gene 3430880..3431293 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" CDS 3431315..3432505 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" gene 3431315..3432505 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" CDS complement(3432596..3434002) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" gene complement(3432596..3434002) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" downshifts complement(3432893) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" promotor_-10 complement(3434035..3434054) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434053) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" promotor_-35 complement(3434069..3434072) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3434108..3435580) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" gene complement(3434108..3435580) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" CDS complement(3435761..3437119) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" gene complement(3435761..3437119) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" downshifts complement(3435775) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" CDS complement(3437119..3437688) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" gene complement(3437119..3437688) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" promotor_-10 complement(3437707..3437718) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3437725) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" promotor_-35 complement(3437732..3437738) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3437795..3437962) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" gene complement(3437795..3437962) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo CDS complement(3437872..3438336) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" gene complement(3437872..3438336) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" promotor_-10 complement(3438366..3438385) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3438371) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" promotor_-35 complement(3438399..3438406) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3438537..3438540 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3438555..3438574 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3438559 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" CDS 3438618..3439832 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" gene 3438618..3439832 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" promotor_-10 complement(3439448..3439466) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3439449) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3439480..3439487) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3439698..3439704 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3439718..3439737 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3439720 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" CDS 3439844..3440194 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" gene 3439844..3440194 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" downshifts 3440187 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" promotor_-35 3440246..3440254 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3440268..3440276 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3440275 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" promotor_-35 3440317..3440326 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3440339..3440354 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3440343 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" CDS 3440375..3440956 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" gene 3440375..3440956 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" promotor_-10 complement(3440473..3440492) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3440483) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3440506..3440514) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3440937 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" CDS complement(3440997..3441419) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" gene complement(3440997..3441419) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" downshifts complement(3441016) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" promotor_-10 complement(3441454..3441469) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3441473) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" promotor_-35 complement(3441482..3441491) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3441530..3442381) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" gene complement(3441530..3442381) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" downshifts complement(3441539) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" downshifts complement(3441781) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" promotor_-35 3442018..3442020 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3442037..3442056 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3442038..3442384 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3442038 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" misc_feature 3442376..3442379 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3442386..3442521 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3442386 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" upshifts complement(3442415) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" misc_feature complement(3442421..3442430) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3442522..3443013 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" gene 3442522..3443013 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" promotor_-35 3442751..3442756 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3442772..3442790 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3442783 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" S_feature complement(3442874..3443782) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3443010..3443528 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" gene 3443010..3443528 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" downshifts 3443333 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" downshifts 3443531 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" CDS 3443687..3443818 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " gene 3443687..3443818 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" CDS complement(3443815..3444249) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" gene complement(3443815..3444249) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" downshifts complement(3443827) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3444298..3444317) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3444305) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" S_feature complement(3444307..3444604) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3444332..3444339) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3444378..3444382 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3444399..3444418 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3444411..3444491 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3444412 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" CDS 3444492..3445940 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" gene 3444492..3445940 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" upshifts complement(3444604) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" promotor_-10 complement(3444605..3444623) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3444606..3444949) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3444639..3444645) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3444927..3444945) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3444949) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" promotor_-35 complement(3444961..3444966) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3445929 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" CDS complement(3445961..3446734) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" gene complement(3445961..3446734) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" downshifts complement(3445983) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" promotor_-35 3446809..3446812 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3446828..3446847 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3446832 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" CDS 3446879..3447262 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" gene 3446879..3447262 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" downshifts 3447249 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" CDS complement(3447297..3447938) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" gene complement(3447297..3447938) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" downshifts complement(3447347) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" CDS complement(3448006..3448407) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" gene complement(3448006..3448407) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" promotor_-10 complement(3448456..3448475) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3448466) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" S_feature complement(3448468..3448541) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3448490..3448495) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3448542..3450251) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" gene complement(3448542..3450251) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" CDS complement(3450248..3450622) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" gene complement(3450248..3450622) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" CDS complement(3450619..3450936) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" gene complement(3450619..3450936) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" S_feature complement(3450937..3451021) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3451021) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" misc_feature complement(3451023..3451036) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3451023..3451116) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3451117..3451281) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" gene complement(3451117..3451281) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" promotor_-10 complement(3451204..3451222) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3451216) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" promotor_-35 complement(3451234..3451242) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3451282..3451453) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3451454..3451636) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" gene complement(3451454..3451636) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo S_feature complement(3451637..3451783) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3451771..3451790) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3451783) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" S_feature complement(3451785..3451898) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3451805..3451812) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" upshifts 3451912 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3451915..3451919 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3451932..3452120) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" gene complement(3451932..3452120) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" downshifts complement(3451943) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" downshifts 3452110 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3452146..3452164) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3452157) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" promotor_-35 complement(3452178..3452184) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3452193..3452693) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" gene complement(3452193..3452693) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" promotor_-10 complement(3452729..3452748) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3452736) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" promotor_-35 complement(3452762..3452768) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3452828..3453961) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" gene complement(3452828..3453961) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" downshifts complement(3452846) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" misc_feature complement(3453988..3454007) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3453995) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" promotor_-10 complement(3454058..3454076) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454074) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" promotor_-35 complement(3454090..3454097) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3454153..3455178) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" gene complement(3454153..3455178) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" downshifts complement(3454166) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" CDS complement(3455194..3455982) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" gene complement(3455194..3455982) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" promotor_-10 complement(3456008..3456027) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456014) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" S_feature complement(3456016..3456227) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3456041..3456048) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3456228..3456389) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" gene complement(3456228..3456389) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" promotor_-10 complement(3456402..3456420) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3456422) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" promotor_-35 complement(3456434..3456440) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3456483..3457157) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" gene complement(3456483..3457157) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" downshifts complement(3456498) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" CDS complement(3457210..3457350) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" gene complement(3457210..3457350) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" CDS complement(3457481..3458164) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" gene complement(3457481..3458164) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" promotor_-35 3458541..3458545 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3458550..3459581) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" gene complement(3458550..3459581) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" promotor_-10 3458560..3458579 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3458566) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" upshifts 3458578 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3459609..3459627) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3459622) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" S_feature complement(3459624..3459741) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3459643..3459648) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3459683..3459688 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3459700..3462360 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3459700 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" promotor_-10 3459704..3459722 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3459777..3461087) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" gene complement(3459777..3461087) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" downshifts complement(3459786) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" promotor_-10 complement(3461111..3461130) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3461118) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" CDS complement(3461121..3461861) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" gene complement(3461121..3461861) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" promotor_-35 complement(3461144..3461153) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3461492) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" promotor_-10 complement(3461494..3461502) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3461516..3461524) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3461616..3461631) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3461624) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" promotor_-35 complement(3461644..3461653) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3461862..3461989) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3461990..3462220) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" gene complement(3461990..3462220) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" S_feature complement(3462221..3462483) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3462356..3462375 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3462362 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" CDS 3462390..3462863 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" gene 3462390..3462863 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" promotor_-10 complement(3462467..3462486) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3462483) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" S_feature complement(3462485..3462868) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3462501..3462504) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3462897..3463295) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" gene complement(3462897..3463295) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" downshifts complement(3462913) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" promotor_-10 complement(3463287..3463305) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3463296) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" promotor_-35 complement(3463319..3463325) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3463319..3464740) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" gene complement(3463319..3464740) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" CDS complement(3464766..3465629) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" gene complement(3464766..3465629) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" S_feature complement(3465630..3465705) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3465706..3467214) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" gene complement(3465706..3467214) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" CDS complement(3467231..3467776) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" gene complement(3467231..3467776) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" CDS complement(3467773..3468285) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" gene complement(3467773..3468285) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" S_feature complement(3468286..3468447) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3468448..3468660) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" gene complement(3468448..3468660) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" CDS complement(3468706..3469440) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" gene complement(3468706..3469440) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" promotor_no_box 3469254..3469354 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3469314 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3469448..3469831) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" gene complement(3469448..3469831) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" misc_feature complement(3469520..3469538) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3469522) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" S_feature complement(3469832..3470102) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3470064..3470073 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3470073 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3470078..3470097) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3470087..3470106 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3470102) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" S_feature complement(3470104..3470225) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3470110..3470117) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3470254..3470883) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" gene complement(3470254..3470883) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" downshifts complement(3470270) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" promotor_-10 complement(3470927..3470946) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3470950) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" promotor_-35 complement(3470961..3470968) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3471018..3472265) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" gene complement(3471018..3472265) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" downshifts complement(3471041) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3472307..3472326) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3472324) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" S_feature complement(3472326..3472410) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3472341..3472346) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3472455) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" CDS complement(3472472..3473014) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" gene complement(3472472..3473014) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" CDS complement(3473027..3473476) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" gene complement(3473027..3473476) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" S_feature complement(3473477..3473576) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3473568..3473587) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3473576) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" promotor_-35 complement(3473601..3473608) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3473633..3474085) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" gene complement(3473633..3474085) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" promotor_-10 complement(3474102..3474121) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3474120) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" promotor_-35 complement(3474136..3474139) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3474161..3474718) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" gene complement(3474161..3474718) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" promotor_-10 complement(3474745..3474763) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3474758) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" promotor_-35 complement(3474779..3474784) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3474797..3475837) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" gene complement(3474797..3475837) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" downshifts complement(3474802) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" S_feature complement(3475838..3475902) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3475892..3475911) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3475902) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" S_feature complement(3475904..3475993) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3475927..3475931) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3475994..3476437) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" gene complement(3475994..3476437) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" CDS complement(3476504..3477178) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" gene complement(3476504..3477178) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" promotor_-10 complement(3476940..3476958) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3476947) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" promotor_-35 complement(3476973..3476979) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3477210..3477227) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3477211) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" promotor_-35 complement(3477243..3477248) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3477284 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" misc_feature 3477288..3477307 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3477319..3477681 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" gene 3477319..3477681 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" downshifts complement(3477694) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" CDS complement(3477698..3477985) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" gene complement(3477698..3477985) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" S_feature complement(3477986..3478044) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3478042..3478061) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3478045..3478911) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" gene complement(3478045..3478911) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" upshifts complement(3478058) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" promotor_-35 complement(3478074..3478083) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3478913..3479983) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" gene complement(3478913..3479983) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" downshifts complement(3478916) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" downshifts 3479984 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" promotor_-10 complement(3480011..3480030) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3480035) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" S_feature complement(3480037..3480148) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3480044..3480050) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3480080..3480099 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3480094 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" CDS 3480109..3480495 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" gene 3480109..3480495 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" promotor_-10 complement(3480130..3480148) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3480148) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" promotor_-35 complement(3480162..3480169) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3480563..3480571 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3480582..3480600 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3480583 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" CDS 3480617..3481171 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" gene 3480617..3481171 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" misc_feature 3481101..3481105 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3481106 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3481150 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" CDS complement(3481205..3482164) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" gene complement(3481205..3482164) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" downshifts complement(3481227) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3482202..3482220) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3482216) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3482235..3482241) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3482246..3483994) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" gene complement(3482246..3483994) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" promotor_-10 complement(3482720..3482738) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3482728) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3482753..3482759) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3483995..3484085) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3484069..3484088) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484085) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3484102..3484109) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3484228) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" CDS complement(3484233..3484820) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" gene complement(3484233..3484820) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" CDS complement(3484909..3485109) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" gene complement(3484909..3485109) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" downshifts complement(3484922) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" S_feature complement(3485110..3485187) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3485183..3485202) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3485187) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" promotor_-35 complement(3485216..3485223) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3485228..3486511) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" gene complement(3485228..3486511) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" S_feature complement(3486512..3486814) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3486542..3486703) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" gene complement(3486542..3486703) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" promotor_-10 complement(3486794..3486813) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3486814) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" promotor_-35 complement(3486829..3486833) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3486918..3487883) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" gene complement(3486918..3487883) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" downshifts complement(3486924) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" promotor_-35 3487500..3487509 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3487522..3487541 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3487530 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3487914..3489203) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" gene complement(3487914..3489203) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" S_feature complement(3489204..3489563) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3489582..3490220) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" gene complement(3489582..3490220) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" downshifts complement(3489608) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" S_feature complement(3490221..3490339) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3490340..3491197) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" gene complement(3490340..3491197) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" S_feature complement(3491198..3491324) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3491306..3491325) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3491324) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" promotor_-35 complement(3491339..3491346) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3491378..3491752) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" gene complement(3491378..3491752) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" promotor_-10 complement(3491792..3491810) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3491806) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" S_feature complement(3491808..3492447) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3491809..3491812 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3491821..3491829) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3491828..3491847 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3491841 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" promotor_-35 3491855..3491860 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3491876..3491895 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3491886 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" CDS 3491918..3492439 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" gene 3491918..3492439 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" promotor_-35 3492382..3492385 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3492400..3492419 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3492414 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3492437..3492456) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3492447) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" downshifts 3492458 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3492471..3492478) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3492521..3494128) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" gene complement(3492521..3494128) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" downshifts complement(3492534) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" S_feature complement(3494129..3494316) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3494304..3494323) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3494316) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" promotor_-35 complement(3494338..3494345) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3494370..3494891) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" gene complement(3494370..3494891) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" downshifts complement(3494426) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" S_feature complement(3494892..3494994) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3494975..3494994) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3494994) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" S_feature complement(3494996..3495073) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3495010..3495013) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3495074..3496213) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" gene complement(3495074..3496213) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" CDS complement(3496210..3498327) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" gene complement(3496210..3498327) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" S_feature complement(3498328..3498386) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3498387..3498406) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3498400) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" promotor_-35 complement(3498420..3498427) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3498426..3498432 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3498446..3498457 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3498451 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" CDS 3498482..3499678 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" gene 3498482..3499678 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" S_feature complement(3498674..3499552) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3499542..3499560) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3499553) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" promotor_-35 complement(3499576..3499581) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3499691..3500653 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" gene 3499691..3500653 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" promotor_-35 3500667..3500673 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3500688..3500706 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3500688 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" CDS 3500734..3501006 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" gene 3500734..3501006 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" downshifts complement(3500740) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" downshifts 3500996 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" S_feature 3501041..3501447 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3501048..3501572) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" gene complement(3501048..3501572) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" downshifts complement(3501070) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" CDS complement(3501582..3503309) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" gene complement(3501582..3503309) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" promotor_-10 complement(3503343..3503362) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3503357) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" promotor_-35 complement(3503376..3503382) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3503398..3504900) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" gene complement(3503398..3504900) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" promotor_-10 complement(3504924..3504942) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3504942) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" promotor_-35 complement(3504957..3504963) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3504987..3505359) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3505030) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" CDS complement(3505386..3506057) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" gene complement(3505386..3506057) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" downshifts complement(3505404) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" CDS complement(3506054..3506608) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" gene complement(3506054..3506608) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" CDS complement(3506634..3508097) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" gene complement(3506634..3508097) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" CDS complement(3508087..3511773) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" gene complement(3508087..3511773) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" misc_feature complement(3511804..3511823) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3511828) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" S_feature complement(3511830..3511959) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3511969..3512445) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" gene complement(3511969..3512445) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" downshifts complement(3512004) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" promotor_-10 complement(3512468..3512487) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3512480) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" promotor_-35 complement(3512502..3512505) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3512552 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" misc_feature 3512555..3512574 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3512589..3513308 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" gene 3512589..3513308 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" downshifts 3513292 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" CDS complement(3513340..3514056) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" gene complement(3513340..3514056) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" downshifts complement(3513342) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" downshifts complement(3513412) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" misc_feature complement(3514082..3514101) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3514094) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" CDS complement(3514155..3515342) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" gene complement(3514155..3515342) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" misc_feature complement(3515372..3515391) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3515390) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" CDS complement(3515478..3517148) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" gene complement(3515478..3517148) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" downshifts complement(3515480) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" CDS complement(3517145..3517573) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" gene complement(3517145..3517573) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" misc_feature 3517641..3517655 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3517641..3517660) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3517648 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3517657) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" promotor_-35 complement(3517677..3517680) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3517712..3517731) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3517724) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" promotor_-35 3517804..3517811 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3517819 /Source="Nicolas_upshifts" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" promotor_-10 3517824..3517843 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3517868 /Source="Nicolas_upshifts" /id="D1933" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="8.77621" /MaxDrop="1.77243" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4576 /isTUend="FALSE" CDS 3517886..3518017 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12696888, 15743949, 16095584, 17213266, 27914001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12696888, 15743949, 16095584, 17213266, 27914001; Product type f: factor" /codon_start=1 /transl_table=11 /product="subtilosin A" /protein_id="NP_391616.1" /db_xref="EnsemblGenomes-Gn:BSU37350" /db_xref="EnsemblGenomes-Tr:CAB15763" /db_xref="GOA:O07623" /db_xref="InterPro:IPR021539" /db_xref="PDB:1PXQ" /db_xref="SubtiList:BG12671" /db_xref="UniProtKB/Swiss-Prot:O07623" /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG* " gene 3517886..3518017 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" CDS 3517974..3518126 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin-like product" /protein_id="YP_054594.1" /db_xref="EnsemblGenomes-Gn:BSU37360" /db_xref="EnsemblGenomes-Tr:CAE01468" /db_xref="SubtiList:BG14182" /db_xref="UniProtKB/Swiss-Prot:Q7WY57" /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIH TQPFFI*" gene 3517974..3518126 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" downshifts 3518006 /Source="Nicolas_upshifts" /id="D1934" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="8.85351" /MaxDrop="5.1396" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4714 /isTUend="FALSE" promotor_-35 3518121..3518127 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3518142..3518161 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3518145 /Source="Nicolas_upshifts" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" CDS 3518151..3519497 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /EC_number="1.21.98.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066831, 15743949, 22366720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066831, 15743949, 22366720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subtilosin A thioether formation enzyme" /protein_id="NP_391617.1" /db_xref="EnsemblGenomes-Gn:BSU37370" /db_xref="EnsemblGenomes-Tr:CAB15764" /db_xref="GOA:P71011" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR008792" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017200" /db_xref="InterPro:IPR023885" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG12471" /db_xref="UniProtKB/Swiss-Prot:P71011" /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDL NKTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRA SRHTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADML FDNGVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQK IIVGISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHD MAQKVRDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHRKFMEYEQHVIDEFKDLIPII PYERKRAANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLW QAQAPRFSEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI*" gene 3518151..3519497 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" CDS 3519510..3519671 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809709, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809709, 15743949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane component involved in subtilosin production" /protein_id="NP_391618.1" /db_xref="EnsemblGenomes-Gn:BSU37380" /db_xref="EnsemblGenomes-Tr:CAB15765" /db_xref="GOA:P71010" /db_xref="SubtiList:BG12470" /db_xref="UniProtKB/Swiss-Prot:P71010" /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFG MRARKADSR*" gene 3519510..3519671 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" CDS 3519668..3520387 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /function="16.5: Explore" /function="16.6: Maintain" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter involved in subtilosin production" /protein_id="NP_391619.1" /db_xref="EnsemblGenomes-Gn:BSU37390" /db_xref="EnsemblGenomes-Tr:CAB15766" /db_xref="GOA:P71009" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12469" /db_xref="UniProtKB/Swiss-Prot:P71009" /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKT TLINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDY VSFVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLF ILDEPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQK VIPIGEETDLRREFFEVIGHE*" gene 3519668..3520387 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" CDS 3520380..3521690 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949, 15849754, 16850406, 18034824; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral membrane protein involved in subtilosinproduction and immunity" /protein_id="NP_391620.1" /db_xref="EnsemblGenomes-Gn:BSU37400" /db_xref="EnsemblGenomes-Tr:CAB15767" /db_xref="GOA:P71008" /db_xref="SubtiList:BG12468" /db_xref="UniProtKB/Swiss-Prot:P71008" /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQ AGIDESVLRKTYIILALLLMNTYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVV LFVDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVK KKNLMFLLHAAIFACVCISAALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHS FMRRSEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISA LLLICSPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFI SGRSISVLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPL FLAILAGTAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS*" gene 3520380..3521690 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" CDS 3521680..3522840 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /function="16.8: Protect" /function="16.5: Explore" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase involved in subtilosin A production" /protein_id="NP_391621.1" /db_xref="EnsemblGenomes-Gn:BSU37410" /db_xref="EnsemblGenomes-Tr:CAB15768" /db_xref="GOA:P71007" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG12467" /db_xref="UniProtKB/Swiss-Prot:P71007" /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYL KEQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSF PSSLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKA IHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFET ETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHV ITRYDVMNNLLLVSICTDQLHEKDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQF DSPEGLLAYMGVLRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG*" gene 3521680..3522840 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" CDS 3522845..3524125 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949, 25817994; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase involved in subtilosin production" /protein_id="NP_391622.1" /db_xref="EnsemblGenomes-Gn:BSU37420" /db_xref="EnsemblGenomes-Tr:CAB15769" /db_xref="GOA:P71006" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG12466" /db_xref="UniProtKB/Swiss-Prot:P71006" /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDF GSRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNF MFTSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLIS MLSPSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPH LQLEKRPDYHAERKIIPACPPVLSQKMMLGDEERMEDTWTGLQIGALPGQNDLLSIKL YWDIAARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYID VASYYVTQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHI IQDMDAQVFLSLIDAMASSNKAIIHVSQKEAIRQ*" gene 3522845..3524125 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" CDS 3524122..3524823 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein involved in subtilosin production and immunity" /protein_id="NP_391623.1" /db_xref="EnsemblGenomes-Gn:BSU37430" /db_xref="EnsemblGenomes-Tr:CAB15770" /db_xref="GOA:P71005" /db_xref="SubtiList:BG12465" /db_xref="UniProtKB/Swiss-Prot:P71005" /translation="MKQSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVR LGLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAED VKSLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILY LLFCMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSF IYKRFSYHSTASLDL*" gene 3524122..3524823 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" downshifts complement(3524390) /Source="Nicolas_upshifts" /id="D1935" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="0.362109999999999" /MaxDrop="3.55474" /score="6.50386958" /energy="-12" /TU="NA" /idTUdmin="U2945" /TUdmin=0 /isTUend="TRUE" S_feature complement(3524479..3524828) /Source="Nicolas_S_feature" /locus_tag="new_3842651_3843000_c" /HighExp="BT, B36, B60, Pyr, G/S, Mal, S3, G135, M/G, Sw" /AntisenseName="albG" /AntisenseCor="2.0087959212361201E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1449" downshifts complement(3524522) /Source="Nicolas_upshifts" /id="D1936" /incds=1 /nref=6 /ntot=18 /MaxReadThrough="3.01883" /MaxDrop="4.2137" /score="6.50386958" /energy="-12" /TU="U2945" /idTUdmin="U2945" /TUdmin="-132" /isTUend="FALSE" S_feature 3524824..3527306 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3524829..3526205) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" gene complement(3524829..3526205) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" CDS complement(3526244..3527599) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" gene complement(3526244..3527599) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" promotor_-10 complement(3527635..3527654) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3527653) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" promotor_-35 complement(3527667..3527676) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3527779..3527798 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3527780 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" downshifts complement(3527825) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" CDS 3527829..3528974 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" gene 3527829..3528974 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" promotor_-35 3528833..3528837 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3528854..3528873 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3528861 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" downshifts complement(3528944) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" CDS 3528958..3529077 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" gene 3528958..3529077 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" downshifts 3529062 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" S_feature 3529107..3529175 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3529176..3529649 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" gene 3529176..3529649 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" downshifts 3529638 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" CDS complement(3529681..3530553) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" gene complement(3529681..3530553) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" downshifts complement(3529692) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" downshifts complement(3529758) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" CDS complement(3530614..3531444) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" gene complement(3530614..3531444) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" S_feature complement(3531445..3531540) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3531528..3531547) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3531539) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" promotor_-35 complement(3531560..3531567) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3531585..3531590 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3531606..3531624 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3531608 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" CDS 3531646..3533721 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" gene 3531646..3533721 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" downshifts complement(3533774) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" S_feature complement(3533898..3534013) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3533941) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" CDS complement(3534014..3534532) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" gene complement(3534014..3534532) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" CDS complement(3534546..3535205) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" gene complement(3534546..3535205) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" promotor_-35 3535228..3535231 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3535241..3535260) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3535246..3535265 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3535249 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" upshifts complement(3535259) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" S_feature complement(3535261..3535544) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3535275..3535282) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3535314..3535502 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" gene 3535314..3535502 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" downshifts 3535491 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" CDS complement(3535545..3535964) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" gene complement(3535545..3535964) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" promotor_-10 complement(3536014..3536033) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3536025) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" promotor_-35 complement(3536048..3536055) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3536084..3538000) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" gene complement(3536084..3538000) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" promotor_-10 complement(3537278..3537296) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3537283) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3537313..3537317) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3538031) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" misc_RNA complement(3538054..3538275) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" gene complement(3538054..3538275) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" misc_RNA complement(3538307..3538528) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" gene complement(3538307..3538528) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" S_feature complement(3538560..3538822) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3538571 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" downshifts complement(3538603) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" CDS complement(3538610..3538765) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" gene complement(3538610..3538765) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" promotor_-35 3538772..3538775 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3538784..3538797 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3538791 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3538799..3538818) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3538822) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" promotor_-35 complement(3538832..3538838) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3538845..3540245) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" gene complement(3538845..3540245) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" CDS complement(3540245..3540715) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" gene complement(3540245..3540715) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" downshifts complement(3540671) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" CDS complement(3540827..3541327) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" gene complement(3540827..3541327) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" downshifts complement(3540830) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" CDS complement(3541363..3542664) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" gene complement(3541363..3542664) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" promotor_-10 complement(3542688..3542707) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3542702) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" S_feature complement(3542704..3542825) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3542723..3542725) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3542826..3543050) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" gene complement(3542826..3543050) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" S_feature complement(3543051..3543135) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3543124..3543143) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3543134) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" promotor_-35 complement(3543158..3543161) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3543201..3543207 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3543222..3543233 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3543223 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" CDS 3543265..3544041 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" gene 3543265..3544041 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" downshifts 3544027 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" promotor_-35 3544129..3544136 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3544151..3544170 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3544155..3548381 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3544155 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" CDS complement(3544185..3545075) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" gene complement(3544185..3545075) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" promotor_no_box complement(3545075..3545175) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3545115) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" CDS complement(3545243..3546088) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" gene complement(3545243..3546088) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" downshifts complement(3545406) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" CDS complement(3546137..3547036) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" gene complement(3546137..3547036) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" promotor_-10 complement(3547079..3547098) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3547082) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" promotor_-35 complement(3547112..3547119) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3547183) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" CDS complement(3547183..3548154) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" gene complement(3547183..3548154) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" promotor_-10 complement(3548189..3548208) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3548214) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" promotor_-35 complement(3548224..3548228) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3548302..3548313) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3548305) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" promotor_-35 complement(3548327..3548333) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3548376..3548395 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3548383 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" CDS 3548424..3549188 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" gene 3548424..3549188 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" downshifts 3549175 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" promotor_-35 3549251..3549257 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3549271..3549290 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3549280 /Source="Nicolas_upshifts" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" CDS 3549321..3550100 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /EC_number="1.3.1.-" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 20052993, 23519407, 25644640" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 20052993, 23519407, 25644640; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis" /protein_id="NP_391648.1" /db_xref="EnsemblGenomes-Gn:BSU37680" /db_xref="EnsemblGenomes-Tr:CAB15795" /db_xref="GOA:P39644" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3U49" /db_xref="PDB:3U4C" /db_xref="PDB:3U4D" /db_xref="SubtiList:BG10632" /db_xref="UniProtKB/Swiss-Prot:P39644" /translation="MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVK EDILAKHPEASVIVLAGDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCN IEDMTATFTQKTVAYIDAIKRASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAA LINASKNISIQLAPHNITVNCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGI PMKRVGSAEETAALAAFLASEEASYITGQQISADGGSMKSI*" gene 3549321..3550100 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" downshifts 3550077 /Source="Nicolas_upshifts" /id="D1955" /incds=0 /nref=84 /ntot=226 /MaxReadThrough="3.12719" /MaxDrop="4.87473" /score="3.07615905" /energy="-11.9" /TU="U2965" /idTUdmin="U2964" /TUdmin=0 /isTUend="TRUE" CDS complement(3550115..3551314) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /function="16.4: Excrete" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanine aminotransferase forming tetrahydrotyrosine in bacilysin synthesis" /protein_id="NP_391649.1" /db_xref="EnsemblGenomes-Gn:BSU37690" /db_xref="EnsemblGenomes-Tr:CAB15796" /db_xref="GOA:P39643" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10631" /db_xref="UniProtKB/Swiss-Prot:P39643" /translation="MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDL PTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGG GKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKI DPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKP ASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGL QQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTF ETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG SLQETSR*" gene complement(3550115..3551314) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" CDS complement(3551315..3552499) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux protein for bacilysin excretion, self-protection against bacilysin" /protein_id="NP_391650.1" /db_xref="EnsemblGenomes-Gn:BSU37700" /db_xref="EnsemblGenomes-Tr:CAB15797" /db_xref="GOA:P39642" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR022324" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10630" /db_xref="UniProtKB/Swiss-Prot:P39642" /translation="MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSG VIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALL FITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVEL AVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTM ITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLT YFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFS VAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKG VF*" gene complement(3551315..3552499) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" CDS complement(3552496..3553914) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /EC_number="6.3.2.49" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine-anticapsin ligase" /protein_id="NP_391651.1" /db_xref="EnsemblGenomes-Gn:BSU37710" /db_xref="EnsemblGenomes-Tr:CAB15798" /db_xref="GOA:P39641" /db_xref="InterPro:IPR011761" /db_xref="PDB:3VMM" /db_xref="PDB:3WNZ" /db_xref="PDB:3WO0" /db_xref="PDB:3WO1" /db_xref="SubtiList:BG10629" /db_xref="UniProtKB/Swiss-Prot:P39641" /translation="MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASH AALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGAD AITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTT LEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVT FEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSH ITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNM IPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPE TAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQD VAESIRQIQQHAKLTAKYVLPV*" gene complement(3552496..3553914) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" CDS complement(3553933..3554694) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /EC_number="1.1.1.385" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroanticapsin 7-dehydrogenase" /protein_id="NP_391652.2" /db_xref="EnsemblGenomes-Gn:BSU37720" /db_xref="EnsemblGenomes-Tr:CAB15799" /db_xref="GOA:P39640" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="PDB:5ITV" /db_xref="PDB:5ITW" /db_xref="SubtiList:BG10628" /db_xref="UniProtKB/Swiss-Prot:P39640" /translation="MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEA MVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELS DWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVL QLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRL GKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ*" gene complement(3553933..3554694) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" CDS complement(3554697..3555404) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /EC_number="5.3.3.19" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-((4R)-4-hydroxycyclohexa-1, 5-dien-1-yl)-2-oxopropanoate isomerase" /protein_id="NP_391653.1" /db_xref="EnsemblGenomes-Gn:BSU37730" /db_xref="EnsemblGenomes-Tr:CAB15800" /db_xref="GOA:P39639" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:3H7J" /db_xref="PDB:3H7Y" /db_xref="PDB:3H9A" /db_xref="SubtiList:BG10627" /db_xref="UniProtKB/Swiss-Prot:P39639" /translation="MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPH TNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVI AIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMP FHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIF FPPRYNRAKAKKMKADE*" gene complement(3554697..3555404) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" misc_feature complement(3555300..3555301) /Source="Nicolas_upshift_promotors" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3555301) /Source="Nicolas_upshifts" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" CDS complement(3555394..3556008) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /EC_number="4.1.1.100" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate decarboxylase" /protein_id="NP_391654.1" /db_xref="EnsemblGenomes-Gn:BSU37740" /db_xref="EnsemblGenomes-Tr:CAB15801" /db_xref="GOA:P39638" /db_xref="SubtiList:BG10626" /db_xref="UniProtKB/Swiss-Prot:P39638" /translation="MIILDNSIQTKKRTDSLSKLITVNTLGPEGTSSEYAAKHFISNF TLLQGLNSKLSLHDTFESCIERTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCD TPMYGLAVRPDFEFRDDMLDTSVIVSHPSPINLIKYFTRKDVRFKLVNSTSQAARKVK EGLYDIALTNELARQKYGLTFVKTFKSIPMSWSLFGKGDVDDEN*" gene complement(3555394..3556008) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" promotor_-35 3555566..3555572 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3555588..3555606 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3555599..3556210 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" upshifts 3555599 /Source="Nicolas_upshifts" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" promotor_-10 complement(3556031..3556050) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3556047) /Source="Nicolas_upshifts" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" promotor_-35 complement(3556065..3556072) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3556159) /Source="Nicolas_upshifts" /id="D1956" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="2.28302" /MaxDrop="5.44594" /score="19.4538123" /energy="-5.1" /TU="NA" /idTUdmin="U2969" /TUdmin=902 /isTUend="FALSE" CDS complement(3556160..3557398) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" gene complement(3556160..3557398) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" promotor_-10 complement(3557440..3557459) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3557452) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" promotor_-35 complement(3557471..3557478) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3557608..3559020) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" gene complement(3557608..3559020) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" downshifts complement(3557615) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" CDS complement(3559020..3560720) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" gene complement(3559020..3560720) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" misc_feature complement(3559689..3559705) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3559701) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" CDS complement(3560794..3562341) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" gene complement(3560794..3562341) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" downshifts complement(3560801) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" upshifts complement(3562385) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" S_feature complement(3562387..3562567) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3562388..3562406) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3562568..3563842) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" gene complement(3562568..3563842) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" S_feature complement(3563843..3563925) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3563925) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" misc_feature complement(3563938..3563956) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3564018) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" CDS complement(3564019..3564483) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" gene complement(3564019..3564483) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" S_feature complement(3564484..3564594) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3564576..3564595) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3564594) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" promotor_-35 complement(3564610..3564617) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3564805) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" CDS complement(3564807..3565262) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" gene complement(3564807..3565262) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" misc_feature 3564897..3564916 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3564905 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3565255..3566106) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" gene complement(3565255..3566106) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" CDS complement(3566120..3567067) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" gene complement(3566120..3567067) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" CDS complement(3567067..3567807) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" gene complement(3567067..3567807) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" promotor_-35 3567825..3567830 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3567831 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3567832..3568851) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" gene complement(3567832..3568851) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" promotor_-10 3567845..3567863 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3568715..3568724 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3568737..3568752 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3568748 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3568854..3569576) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" gene complement(3568854..3569576) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" CDS complement(3569569..3570690) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" gene complement(3569569..3570690) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" CDS complement(3570690..3571559) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" gene complement(3570690..3571559) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" CDS complement(3571560..3572729) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" gene complement(3571560..3572729) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" CDS complement(3572750..3574174) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" gene complement(3572750..3574174) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" CDS complement(3574179..3574949) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" gene complement(3574179..3574949) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" promotor_-10 complement(3574984..3575003) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3574998) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" promotor_-35 complement(3575017..3575026) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3575117..3575122 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3575138..3575156 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3575140..3575268 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3575140 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" CDS 3575269..3575814 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" gene 3575269..3575814 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" downshifts 3575800 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" CDS complement(3575858..3576229) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" gene complement(3575858..3576229) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" downshifts complement(3575876) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" CDS complement(3576291..3577613) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" gene complement(3576291..3577613) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" CDS complement(3577633..3577950) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" gene complement(3577633..3577950) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" promotor_-10 complement(3577979..3577998) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3577990) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" promotor_-35 complement(3578012..3578018) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3578053..3578060 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3578076..3578095 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3578079 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" CDS 3578118..3579488 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" gene 3578118..3579488 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" CDS complement(3579513..3580190) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" gene complement(3579513..3580190) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" downshifts complement(3579527) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3580017..3580036) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3580033) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3580052..3580057) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3580204..3581010) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" gene complement(3580204..3581010) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" promotor_-10 complement(3580503..3580521) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3580517) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" promotor_-35 complement(3580536..3580542) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3581039..3581058) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3581045) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" promotor_-35 complement(3581074..3581081) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3581100..3581633) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" gene complement(3581100..3581633) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" CDS complement(3581681..3582316) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" gene complement(3581681..3582316) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" CDS complement(3582309..3582647) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" gene complement(3582309..3582647) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" promotor_-10 complement(3582669..3582688) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3582680) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" promotor_-35 complement(3582703..3582710) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3582731..3582734 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3582749..3582768 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3582749 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" CDS 3582791..3583606 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" gene 3582791..3583606 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" downshifts 3583585 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" downshifts complement(3583661) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" CDS complement(3583696..3583944) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" gene complement(3583696..3583944) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" downshifts complement(3583716) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" upshifts complement(3583962) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" S_feature complement(3583964..3584037) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3583972..3583978) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3584038..3585477) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" gene complement(3584038..3585477) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" CDS complement(3585474..3586859) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" gene complement(3585474..3586859) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" misc_feature complement(3586878..3586887) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3586892) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" S_feature complement(3586894..3586958) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3586937..3586954) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3586958) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" promotor_-35 complement(3586970..3586977) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3587000..3587019) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3587018) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" promotor_-35 complement(3587033..3587040) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3587099..3587102 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3587109 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" promotor_-10 3587117..3587136 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3587161..3587931 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" gene 3587161..3587931 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" S_feature 3587932..3588999 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3587970..3588800) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" gene complement(3587970..3588800) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" downshifts complement(3587971) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3588826..3588845) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3588832) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" CDS complement(3588840..3589142) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" gene complement(3588840..3589142) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" promotor_-35 complement(3588860..3588867) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3589143..3589281) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3589266..3589285) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3589281) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" promotor_-35 3589596..3589604 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3589615..3589633 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3589616 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" CDS 3589672..3592092 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" gene 3589672..3592092 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" upshifts 3589830 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3589839..3589858 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3592080 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" CDS complement(3592130..3593131) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " gene complement(3592130..3593131) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" S_feature complement(3593132..3593293) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3593305..3594054) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" gene complement(3593305..3594054) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" downshifts complement(3593338) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" promotor_-10 complement(3594072..3594091) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3594089) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" promotor_-35 complement(3594106..3594109) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3594160..3595341) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" gene complement(3594160..3595341) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" downshifts complement(3594174) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3595342..3595473) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3595467..3595482) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3595473) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" promotor_-35 complement(3595494..3595503) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3595708..3595715 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3595726..3595836 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3595726..3595745 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3595726 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" CDS 3595837..3596100 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" gene 3595837..3596100 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" downshifts 3595990 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" downshifts 3596106 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" CDS complement(3596143..3596517) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" gene complement(3596143..3596517) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" downshifts complement(3596154) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" CDS complement(3596519..3597133) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" gene complement(3596519..3597133) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" CDS complement(3597147..3599096) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" gene complement(3597147..3599096) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" misc_feature 3598360..3598379 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3598366 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_no_box 3598790..3598890 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3598850 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3598960 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" CDS complement(3599124..3600089) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" gene complement(3599124..3600089) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" S_feature complement(3600090..3600158) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3600145..3600164) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3600158) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" S_feature complement(3600160..3600345) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3600177..3600181) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3600276..3600281 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3600297..3600315 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3600302 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3600336..3600355) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3600345) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" S_feature complement(3600347..3600456) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3600370..3600374) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3600412 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(3600441..3600460) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3600456) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" promotor_-35 complement(3600476..3600480) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3600534..3600552) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3600539..3600545 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3600551) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" promotor_-10 3600560..3600578 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3600563 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" promotor_-35 complement(3600568..3600573) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3600605..3600850 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" gene 3600605..3600850 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" downshifts 3600832 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" CDS complement(3600921..3602462) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" gene complement(3600921..3602462) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" downshifts complement(3600950) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" CDS complement(3602466..3603638) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" gene complement(3602466..3603638) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" promotor_-10 complement(3603656..3603674) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3603678) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" promotor_-35 complement(3603689..3603695) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3603719..3604102) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" gene complement(3603719..3604102) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" CDS complement(3604120..3604791) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" gene complement(3604120..3604791) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" promotor_-10 complement(3604813..3604832) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3604822) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" promotor_-35 complement(3604848..3604851) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3604932..3604935 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3604950..3604969 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3604959..3605146 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3604959 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" CDS 3605147..3605305 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" gene 3605147..3605305 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" S_feature 3605306..3605690 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3605671..3605676 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3605692..3605710 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3605692 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" CDS 3605748..3606056 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" gene 3605748..3606056 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" downshifts complement(3605834) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3605838..3605938) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3605878) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3606053..3607594 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" gene 3606053..3607594 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" downshifts 3607585 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" CDS complement(3607625..3608227) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" gene complement(3607625..3608227) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" downshifts complement(3607639) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" S_feature complement(3608228..3608509) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3608510..3609760) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" gene complement(3608510..3609760) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" downshifts complement(3608606) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" CDS complement(3609779..3610936) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" gene complement(3609779..3610936) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" misc_feature complement(3609852..3609871) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3609879) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" CDS complement(3610933..3612378) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" gene complement(3610933..3612378) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" promotor_-10 complement(3612412..3612431) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3612422) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" promotor_-35 complement(3612445..3612452) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3612535..3613203) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" gene complement(3612535..3613203) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" downshifts complement(3612544) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" CDS complement(3613200..3614018) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" gene complement(3613200..3614018) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" CDS complement(3614026..3614931) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" gene complement(3614026..3614931) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" misc_feature complement(3614666..3614685) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3614677) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" promotor_-10 complement(3614972..3614991) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3614982..3614989 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3614993) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" upshifts 3615001 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" promotor_-10 3615003..3615022 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3615007..3615014) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3615037..3615423 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" gene 3615037..3615423 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" CDS 3615405..3616082 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" gene 3615405..3616082 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" downshifts 3616054 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" promotor_-35 3616126..3616133 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3616144 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" promotor_-10 3616147..3616166 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3616186..3617385 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" gene 3616186..3617385 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" CDS 3617419..3617616 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" gene 3617419..3617616 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" downshifts 3617595 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" CDS complement(3617652..3618842) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" gene complement(3617652..3618842) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" downshifts complement(3617667) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" downshifts complement(3617751) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" misc_feature complement(3618866..3618885) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3618882) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" promotor_-35 3618902..3618909 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3618918 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" promotor_-10 3618923..3618942 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3618963..3619343 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" gene 3618963..3619343 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" downshifts 3619241 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" downshifts 3619312 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" CDS complement(3619381..3620058) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" gene complement(3619381..3620058) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" downshifts complement(3619388) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3620067..3620086) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3620092) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" promotor_-35 complement(3620098..3620104) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3620135..3621469) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" gene complement(3620135..3621469) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" misc_feature complement(3621517..3621535) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3621540) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" promotor_-35 3621634..3621641 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3621646 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" promotor_-10 3621655..3621673 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3621697..3623634 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" gene 3621697..3623634 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" promotor_-10 complement(3622841..3622860) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3622842) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3622874..3622882) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3623624 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" promotor_-35 3623737..3623744 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3623759..3623778 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3623778 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3623990..3623997 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3624010..3624029 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3624010 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" CDS 3624062..3625441 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" gene 3624062..3625441 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" S_feature complement(3625150..3626353) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3625495..3626337 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" gene 3625495..3626337 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" CDS complement(3626388..3627248) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" gene complement(3626388..3627248) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" downshifts complement(3626398) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" downshifts 3627232 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" promotor_-10 complement(3627270..3627288) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3627288) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" promotor_-35 complement(3627303..3627309) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3627358..3628071) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" gene complement(3627358..3628071) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" promotor_-35 3627473..3627474 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3627494..3627511 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3627496 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3628099..3628110) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3628100) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3628125..3628131) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3628146..3628152 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3628167..3628186 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3628177 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" CDS 3628222..3628737 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" gene 3628222..3628737 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" misc_RNA 3628738..3628944 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" gene 3628738..3628944 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" downshifts 3628904 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" CDS 3628986..3630227 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" gene 3628986..3630227 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" promotor_-35 3630318..3630326 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3630337..3630355 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3630348 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" CDS 3630383..3631750 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" gene 3630383..3631750 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" downshifts 3631727 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" CDS complement(3631780..3632412) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" gene complement(3631780..3632412) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" downshifts complement(3631798) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3632448..3632463) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3632456) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" promotor_-35 complement(3632476..3632484) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3632554..3633489) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" gene complement(3632554..3633489) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" downshifts complement(3632566) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" promotor_-35 3633233..3633242 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3633256..3633275 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3633260 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3633490..3633577) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3633560..3633579) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3633577) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" promotor_-35 complement(3633595..3633599) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3633622..3633634) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3633622) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" promotor_-35 complement(3633649..3633655) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3633652..3633786) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" gene complement(3633652..3633786) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" promotor_-35 3633733..3633740 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3633754..3633773 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3633763 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" S_feature 3633766..3633870 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3633865..3633874 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3633872 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" promotor_-10 3633886..3633901 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3633908) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3633910..3633924) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3633936..3634085 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" gene 3633936..3634085 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" CDS 3634103..3635614 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" gene 3634103..3635614 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" CDS 3635611..3636798 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" gene 3635611..3636798 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" CDS 3636815..3637051 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" gene 3636815..3637051 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" CDS 3637051..3638229 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" gene 3637051..3638229 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" S_feature 3638230..3638319 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3638320..3639078 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" gene 3638320..3639078 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" downshifts 3639046 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" S_feature complement(3639080..3640307) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3639126..3639133 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3639147..3639166 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3639160 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" CDS 3639219..3640310 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" gene 3639219..3640310 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" downshifts 3640212 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" downshifts 3640300 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" CDS complement(3640344..3641672) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" gene complement(3640344..3641672) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" downshifts complement(3640352) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" CDS complement(3641669..3642001) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" gene complement(3641669..3642001) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" CDS complement(3642020..3643378) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" gene complement(3642020..3643378) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" CDS complement(3643394..3643702) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" gene complement(3643394..3643702) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" promotor_-10 complement(3643747..3643766) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3643763) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" promotor_-35 complement(3643780..3643786) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3643831) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" CDS complement(3643831..3645756) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" gene complement(3643831..3645756) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" promotor_-35 3644494..3644503 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3644517..3644536 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3644525 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3645829..3645846) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3645853) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" promotor_-35 complement(3645861..3645868) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3645919..3646077) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" gene complement(3645919..3646077) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" downshifts complement(3645946) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" CDS complement(3646106..3646696) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" gene complement(3646106..3646696) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" promotor_-10 complement(3646724..3646742) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3646735) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" promotor_-35 complement(3646756..3646762) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3646765..3646771 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3646787..3646805 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3646790 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" CDS 3646825..3648468 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" gene 3646825..3648468 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" S_feature complement(3646962..3648511) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3648463 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" S_feature complement(3648513..3648604) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3648515..3648521 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3648529 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3648536..3648555 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3648556) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" CDS 3648573..3649775 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" gene 3648573..3649775 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" S_feature complement(3648606..3649771) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3648649) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" CDS complement(3649772..3650548) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" gene complement(3649772..3650548) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" CDS complement(3650545..3651432) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" gene complement(3650545..3651432) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" CDS complement(3651439..3651627) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" gene complement(3651439..3651627) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" CDS complement(3651624..3651830) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" gene complement(3651624..3651830) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" CDS complement(3651827..3652147) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" gene complement(3651827..3652147) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" promotor_-35 3651960..3651969 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3651982..3652001 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3651984 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3652140..3652676) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" gene complement(3652140..3652676) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" upshifts complement(3652704) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" promotor_-10 complement(3652705..3652720) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3652732..3652741) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3652807..3652814 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3652828..3652847 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3652837 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" CDS 3652888..3654261 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" gene 3652888..3654261 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" S_feature complement(3653168..3653710) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3653698..3653717) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3653710) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3653732..3653739) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3654096 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" CDS complement(3654276..3655106) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" gene complement(3654276..3655106) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" downshifts complement(3654282) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" promotor_-10 complement(3655125..3655143) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3655140) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" promotor_-35 complement(3655158..3655164) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3655184) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3655186..3655205) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3655192..3656919) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" gene complement(3655192..3656919) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" downshifts complement(3655291) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" CDS complement(3656916..3658619) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" gene complement(3656916..3658619) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" CDS complement(3658619..3659635) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" gene complement(3658619..3659635) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" promotor_-10 complement(3659509..3659527) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3659518) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" promotor_-35 complement(3659543..3659548) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3659619..3661025) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" gene complement(3659619..3661025) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" S_feature complement(3661026..3661234) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3661217..3661236) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3661234) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" S_feature complement(3661236..3661344) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3661250..3661255) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3661341..3661360) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3661356) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" promotor_-35 complement(3661374..3661381) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3661502..3661509 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3661519 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" promotor_-10 3661524..3661542 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3661581..3662933 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" gene 3661581..3662933 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" S_feature complement(3662532..3665014) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3662918 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" misc_feature 3663009..3663028 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3663015 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" CDS 3663055..3664743 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" gene 3663055..3664743 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" promotor_-35 3664741..3664750 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3664762..3664777 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3664766 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" CDS 3664801..3665001 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" gene 3664801..3665001 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" S_feature 3665002..3665946 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3665015..3665854) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" gene complement(3665015..3665854) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" promotor_-10 complement(3665880..3665898) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3665898) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" promotor_-35 complement(3665911..3665918) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3665913 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" CDS complement(3665961..3667058) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" gene complement(3665961..3667058) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" downshifts complement(3665962) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(3667091..3667110) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3667108) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" S_feature complement(3667110..3667178) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3667123..3667130) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3667179..3668072) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" gene complement(3667179..3668072) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" promotor_-10 complement(3668099..3668118) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3668118) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" promotor_-35 complement(3668132..3668139) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3668146..3668151 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3668167..3668185 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3668176 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3668193..3668199 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3668214..3668232 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3668220 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" CDS 3668256..3669713 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" gene 3668256..3669713 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" promotor_-10 complement(3669139..3669157) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3669154) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3669172..3669177) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3669694 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" downshifts 3669738 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" CDS complement(3669755..3670591) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" gene complement(3669755..3670591) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" downshifts complement(3669773) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" misc_RNA complement(3670668..3670770) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" gene complement(3670668..3670770) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" downshifts complement(3670694) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3670796..3670815) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3670807) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" S_feature complement(3670809..3671550) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3670829..3670835) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3670887..3670894 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3670907..3670925 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3670916 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" S_feature 3670926..3671011 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3670987..3670994 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3671008..3671027 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3671013 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" CDS 3671159..3671701 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" gene 3671159..3671701 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" promotor_-10 complement(3671526..3671545) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3671550) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" promotor_-35 complement(3671559..3671568) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3671691 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" S_feature 3671736..3672058 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3671776..3672795) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" gene complement(3671776..3672795) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" downshifts complement(3671794) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3672821..3672840) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3672835) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" promotor_-35 complement(3672855..3672858) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3672910..3673416) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" gene complement(3672910..3673416) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" promotor_-10 complement(3673422..3673441) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3673444) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" promotor_-35 3673446..3673449 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3673455..3673461) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3673464..3673483 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3673467 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" CDS 3673546..3674421 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" gene 3673546..3674421 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" S_feature complement(3673796..3673884) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3673818) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3673844..3673944) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3673884) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" CDS 3674499..3674972 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" gene 3674499..3674972 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" CDS 3674990..3676210 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" gene 3674990..3676210 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" CDS 3676197..3676853 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" gene 3676197..3676853 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" promotor_-35 3676851..3676856 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3676870..3676889 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3676873 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" CDS 3676903..3678135 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" gene 3676903..3678135 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" downshifts complement(3676920) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" downshifts 3678120 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" promotor_-35 3678181..3678190 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3678203..3678218 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3678205..3678427 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3678205 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" downshifts 3678384 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" promotor_-35 3678438..3678444 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3678457..3678557 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3678457 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" promotor_-10 3678459..3678477 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3678536..3678543 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3678557..3678575 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3678559..3678656 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3678559 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" CDS 3678657..3678920 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" gene 3678657..3678920 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" promotor_-35 3678684..3678687 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3678702..3678721 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3678714 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" downshifts 3678868 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" downshifts 3678912 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" promotor_-35 3678987..3678996 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3679002 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" promotor_-10 3679008..3679023 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3679049..3679537 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" gene 3679049..3679537 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" promotor_-35 3679542..3679549 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3679563..3679582 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3679573 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" misc_RNA 3679603..3679709 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 3679603..3679709 /gene="mswI" /locus_tag="BSU_misc_RNA_61" downshifts 3679704 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" CDS 3679792..3680925 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" gene 3679792..3680925 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" S_feature complement(3680065..3680308) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3680303..3680322) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3680312) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" promotor_-35 complement(3680337..3680344) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3680931..3680938 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3680953..3680972 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3680959 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" misc_RNA 3680994..3681100 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 3680994..3681100 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" downshifts 3681047 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" S_feature 3681101..3681177 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3681178..3682314 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" gene 3681178..3682314 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" downshifts 3682301 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" CDS complement(3682367..3683140) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" gene complement(3682367..3683140) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" downshifts complement(3682377) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" CDS complement(3683157..3683807) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" gene complement(3683157..3683807) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" CDS complement(3683804..3684520) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" gene complement(3683804..3684520) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" CDS complement(3684544..3685962) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" gene complement(3684544..3685962) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" promotor_-10 complement(3685130..3685148) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3685149) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" promotor_-35 complement(3685164..3685169) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3685963..3686047) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3686031..3686049) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3686047) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" promotor_-35 complement(3686065..3686070) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3686116..3686964) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" gene complement(3686116..3686964) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" downshifts complement(3686126) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" S_feature complement(3686965..3687150) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3687139..3687158) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3687150) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" S_feature complement(3687152..3687877) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3687174..3687178) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3687312..3687319 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3687332..3687351 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3687341 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" misc_RNA 3687351..3687453 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" gene 3687351..3687453 /gene="gswB" /locus_tag="BSU_misc_RNA_63" S_feature 3687454..3687557 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3687529..3687535 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3687549..3687560 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3687559 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" CDS 3687580..3688773 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" gene 3687580..3688773 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" promotor_-10 complement(3687864..3687882) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3687880) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" promotor_-35 complement(3687895..3687902) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3688549 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" downshifts 3688769 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" CDS complement(3688815..3689243) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" gene complement(3688815..3689243) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo CDS complement(3689244..3689486) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" gene complement(3689244..3689486) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo S_feature complement(3689487..3689550) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3689539..3689554) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3689550) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" promotor_-35 complement(3689566..3689575) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3689583 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" CDS complement(3689631..3689921) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" gene complement(3689631..3689921) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" downshifts complement(3689637) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3689946..3689965) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3689963) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" CDS complement(3689971..3692031) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" gene complement(3689971..3692031) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" promotor_-35 complement(3689979..3689986) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3692060..3692078) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3692064) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" promotor_-35 complement(3692093..3692099) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3692124..3692129 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3692143 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" promotor_-10 3692145..3692163 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3692157..3692231 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3692232..3693512 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" gene 3692232..3693512 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" S_feature 3693513..3693652 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3693609 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" CDS complement(3693670..3694398) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" gene complement(3693670..3694398) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" downshifts complement(3693687) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3694429..3694448) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3694440) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" promotor_-35 complement(3694462..3694469) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3694586..3694693) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3694629) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" CDS complement(3694694..3695527) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" gene complement(3694694..3695527) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" promotor_-10 complement(3695558..3695577) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3695577) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" promotor_-35 complement(3695591..3695598) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3695623..3696303) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" gene complement(3695623..3696303) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" promotor_-10 complement(3696350..3696369) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3696359) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" promotor_-35 complement(3696383..3696390) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3696451..3696454 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3696469..3696488 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3696469 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" CDS 3696510..3697796 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" gene 3696510..3697796 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" promotor_-10 complement(3697241..3697259) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3697249) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3697273..3697280) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3697767 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" CDS complement(3697815..3699254) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" gene complement(3697815..3699254) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" downshifts complement(3697838) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" misc_feature complement(3699278..3699297) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3699295) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" CDS complement(3699336..3700484) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" gene complement(3699336..3700484) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" promotor_-10 complement(3700511..3700527) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3700527) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" S_feature complement(3700529..3700613) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3700542..3700547) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3700614..3700802) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" gene complement(3700614..3700802) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo CDS complement(3700833..3700964) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " gene complement(3700833..3700964) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" CDS complement(3700976..3701437) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" gene complement(3700976..3701437) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" CDS complement(3701453..3701749) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" gene complement(3701453..3701749) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" CDS complement(3701777..3702265) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" gene complement(3701777..3702265) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" CDS complement(3702283..3702735) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" gene complement(3702283..3702735) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" S_feature complement(3702736..3702804) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3702805..3703134) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" gene complement(3702805..3703134) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" S_feature complement(3703135..3703256) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3703257..3703673) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" gene complement(3703257..3703673) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" CDS complement(3703724..3704092) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" gene complement(3703724..3704092) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" CDS complement(3704086..3704556) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" gene complement(3704086..3704556) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" S_feature complement(3704557..3704881) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3704882..3705310) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" gene complement(3704882..3705310) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" CDS complement(3705372..3712376) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" gene complement(3705372..3712376) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" misc_feature 3712383..3712397 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3712397 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3712407..3712426) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3712422) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" promotor_-35 complement(3712441..3712448) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3712538..3713473) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" gene complement(3712538..3713473) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" downshifts complement(3712759) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" S_feature complement(3713474..3713594) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3713625..3714071) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" gene complement(3713625..3714071) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" downshifts complement(3713639) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3714108..3714127) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3714115) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" promotor_-35 complement(3714141..3714148) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3714174..3715583) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" gene complement(3714174..3715583) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" CDS complement(3715606..3717435) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" gene complement(3715606..3717435) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" promotor_no_box complement(3717427..3717527) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3717467) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" S_feature complement(3717469..3717661) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3717642..3717661) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3717661) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" S_feature complement(3717663..3717796) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3717674..3717681) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3717818..3718126) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" gene complement(3717818..3718126) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" downshifts complement(3717841) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" CDS complement(3718172..3718615) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" gene complement(3718172..3718615) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" CDS complement(3718612..3720321) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" gene complement(3718612..3720321) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" misc_feature complement(3719483..3719502) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3719491) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" CDS complement(3720341..3720610) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" gene complement(3720341..3720610) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" CDS complement(3720622..3720987) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" gene complement(3720622..3720987) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" S_feature complement(3720988..3721053) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3721040..3721059) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3721053) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" promotor_-35 complement(3721074..3721077) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3721294..3722703) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" gene complement(3721294..3722703) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" downshifts complement(3721317) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" S_feature complement(3722704..3722813) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3722837..3723001) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" gene complement(3722837..3723001) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" promotor_-10 complement(3722886..3722904) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3722901) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3722915..3722923) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3723193..3723212) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3723209) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3723225..3723232) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3723241..3723248 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3723263..3723282 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3723266 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" CDS 3723320..3723766 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" gene 3723320..3723766 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" downshifts 3723771 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" CDS 3723879..3725405 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" gene 3723879..3725405 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" CDS 3725402..3727060 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" gene 3725402..3727060 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" CDS 3727073..3728338 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" gene 3727073..3728338 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" CDS 3728331..3729290 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" gene 3728331..3729290 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" S_feature 3729291..3729365 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3729366..3730793 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" gene 3729366..3730793 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" downshifts 3730789 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" CDS complement(3730837..3732138) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" gene complement(3730837..3732138) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" downshifts complement(3730854) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" CDS complement(3732168..3733349) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" gene complement(3732168..3733349) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" S_feature complement(3733350..3733429) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3733430..3734101) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" gene complement(3733430..3734101) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" promotor_-35 3734050..3734053 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3734068 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3734069..3734088 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3734129..3734148) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3734144) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" promotor_-35 complement(3734162..3734169) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3734207..3735148) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" gene complement(3734207..3735148) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" promotor_-10 complement(3735193..3735212) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3735199) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" S_feature complement(3735201..3735281) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3735228..3735231) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3735282..3736109) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " gene complement(3735282..3736109) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" downshifts complement(3736081) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(3736134..3736152) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3736147) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" promotor_-35 complement(3736166..3736172) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3736182..3737294) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" gene complement(3736182..3737294) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" CDS complement(3737364..3738701) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" gene complement(3737364..3738701) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" CDS complement(3738698..3739840) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" gene complement(3738698..3739840) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" CDS complement(3739857..3740606) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" gene complement(3739857..3740606) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" CDS complement(3740619..3741293) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" gene complement(3740619..3741293) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" CDS complement(3741316..3742110) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" gene complement(3741316..3742110) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" promotor_-35 3741682..3741691 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3741703 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3741704..3741719 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3742135..3742632) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" gene complement(3742135..3742632) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" CDS complement(3742646..3743971) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" gene complement(3742646..3743971) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" promotor_-10 complement(3744048..3744067) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3744052) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" promotor_-35 complement(3744081..3744088) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3744157..3744384) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" gene complement(3744157..3744384) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" CDS complement(3744371..3745357) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" gene complement(3744371..3745357) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" downshifts complement(3744375) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" promotor_-35 3744508..3744517 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3744531..3744550 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3744541..3745174 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3744541 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" promotor_-10 complement(3745412..3745431) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3745423) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" promotor_-35 complement(3745446..3745453) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3745512..3746324) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" gene complement(3745512..3746324) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" promotor_-10 complement(3746354..3746373) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3746364..3746921) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" gene complement(3746364..3746921) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" upshifts complement(3746377) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" promotor_-35 complement(3746388..3746395) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3746902..3747336) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" gene complement(3746902..3747336) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" promotor_-35 3747361..3747370 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3747380 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" promotor_-10 3747383..3747402 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3747396) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" S_feature complement(3747397..3747808) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3747402..3747416) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3747425..3747429) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3747425..3747790 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" gene 3747425..3747790 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" downshifts 3747804 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" promotor_-10 complement(3747808..3747812) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3747808) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" S_feature complement(3747810..3747896) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-35 complement(3747833) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3747889..3747908) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3747896) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" promotor_-35 complement(3747922..3747929) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3747969..3747975 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3747989..3748000 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3747996 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" CDS 3748038..3748391 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" gene 3748038..3748391 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" downshifts 3748386 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" CDS complement(3748435..3748833) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" gene complement(3748435..3748833) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" downshifts complement(3748443) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(3748848..3748867) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3748864) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" promotor_-35 complement(3748882..3748885) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3748921..3748928 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3748937..3748955) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3748943..3748962 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3748952 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" upshifts complement(3748952) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3748971..3748976) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3749011..3749976 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" gene 3749011..3749976 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" upshifts 3749404 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3749411..3749429 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3749883 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" downshifts 3749954 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" S_feature 3749999..3750795 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3750017..3750364) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" gene complement(3750017..3750364) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" downshifts complement(3750030) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" CDS complement(3750378..3752246) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" gene complement(3750378..3752246) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" CDS complement(3752221..3752994) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" gene complement(3752221..3752994) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" CDS complement(3753138..3754115) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" gene complement(3753138..3754115) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" CDS complement(3754112..3754801) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" gene complement(3754112..3754801) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" promotor_-10 complement(3754828..3754847) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3754846) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" promotor_-35 complement(3754862..3754868) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3754909..3755781) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" gene complement(3754909..3755781) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" downshifts complement(3754913) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" CDS complement(3755802..3756638) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" gene complement(3755802..3756638) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" S_feature complement(3756639..3756723) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3756724..3757593) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" gene complement(3756724..3757593) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" CDS complement(3757613..3758647) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" gene complement(3757613..3758647) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" CDS complement(3758670..3759986) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" gene complement(3758670..3759986) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" CDS complement(3760001..3760894) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" gene complement(3760001..3760894) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" CDS complement(3760911..3762824) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" gene complement(3760911..3762824) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" CDS complement(3762857..3763834) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" gene complement(3762857..3763834) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" CDS complement(3763858..3764673) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" gene complement(3763858..3764673) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" S_feature complement(3764674..3764747) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3764748..3766211) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" gene complement(3764748..3766211) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" S_feature complement(3766212..3766416) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3766215..3766222 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3766238..3766257 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3766245 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" S_feature 3766252..3766558 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3766398..3766417) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3766416) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" S_feature complement(3766418..3766570) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3766432..3766439) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3766518..3766525 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3766540..3766559 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3766560 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" promotor_-10 complement(3766571..3766590) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3766587) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" promotor_-35 complement(3766606..3766613) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3766627..3767382 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" gene 3766627..3767382 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" promotor_-35 3767361..3767367 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3767382..3767401 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3767396 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" CDS 3767436..3768368 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" gene 3767436..3768368 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" downshifts 3768370 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" promotor_-35 3768447..3768454 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3768468..3768487 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3768474..3768629 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3768474 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" CDS 3768630..3769280 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" gene 3768630..3769280 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" CDS 3769284..3769592 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" gene 3769284..3769592 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" downshifts 3769594 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" promotor_-35 3769736..3769742 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3769758..3769776 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3769768 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" CDS 3769830..3771215 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" gene 3769830..3771215 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" downshifts 3771201 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" S_feature 3771246..3771796 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3771257..3773137) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" gene complement(3771257..3773137) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" downshifts complement(3771263) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" S_feature complement(3773138..3773235) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3773226..3773245) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3773235) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" promotor_-35 complement(3773260..3773267) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3773305..3773556) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" gene complement(3773305..3773556) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" downshifts complement(3773323) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" misc_feature complement(3773578..3773597) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3773587) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" promotor_-35 3773620..3773626 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3773640..3773658 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3773641 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" CDS 3773673..3774494 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" gene 3773673..3774494 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" downshifts 3774478 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" CDS complement(3774523..3775665) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" gene complement(3774523..3775665) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" downshifts complement(3774533) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" S_feature complement(3775666..3775765) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3775753..3775772) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3775764) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" promotor_-35 complement(3775786..3775793) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3775808..3777145 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" gene 3775808..3777145 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" S_feature complement(3776550..3777150) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3777184..3777663) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " gene complement(3777184..3777663) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" downshifts complement(3777195) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" CDS complement(3777743..3778735) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" gene complement(3777743..3778735) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" downshifts complement(3777767) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" downshifts 3778725 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" promotor_-10 complement(3778758..3778777) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3778776) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" promotor_-35 complement(3778792..3778799) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3778798..3778805 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3778819..3779243 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3778819 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" promotor_-10 3778820..3778839 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3778825..3779237 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene 3778825..3779237 /gene="srlX" /locus_tag="BSU_misc_RNA_86" upshifts complement(3778845) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3778855..3778869) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3778877..3778881) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3779209 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" CDS 3779244..3779978 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" gene 3779244..3779978 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" CDS 3779978..3780247 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" gene 3779978..3780247 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" CDS 3780251..3780733 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" gene 3780251..3780733 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" CDS 3780754..3782997 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" gene 3780754..3782997 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" CDS 3782994..3784193 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" gene 3782994..3784193 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" promotor_-10 complement(3783949..3783967) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3783971) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3783982..3783988) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3784184 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" downshifts complement(3784257) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" CDS complement(3784257..3785489) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" gene complement(3784257..3785489) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" promotor_-10 complement(3785521..3785540) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3785533) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" promotor_-35 complement(3785554..3785559) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3785590..3786015) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" gene complement(3785590..3786015) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" promotor_-10 complement(3786043..3786062) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3786057) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" promotor_-35 complement(3786075..3786081) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3786207..3786214 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3786224 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" promotor_-10 3786229..3786248 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3786272..3786727 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" gene 3786272..3786727 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" downshifts 3786665 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" S_feature 3786728..3787341 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3786757..3787965) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" gene complement(3786757..3787965) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" downshifts complement(3786784) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" S_feature complement(3787966..3788072) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3788073..3789086) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" gene complement(3788073..3789086) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" S_feature complement(3789087..3789160) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3789145..3789164) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3789160) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" promotor_-35 complement(3789177..3789184) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3789180..3789755) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" gene complement(3789180..3789755) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" downshifts complement(3789204) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3789784..3789803) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3789798) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" promotor_-35 complement(3789818..3789825) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3789826..3789832 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3789847..3789865 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3789854 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" CDS 3789886..3790956 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" gene 3789886..3790956 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" downshifts 3790954 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" CDS complement(3791013..3791444) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" gene complement(3791013..3791444) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" promotor_-35 3791474..3791481 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3791495..3791514 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3791504..3791670 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3791504 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" promotor_-10 complement(3791556..3791575) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3791576) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" promotor_-35 complement(3791590..3791597) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3791671..3792075 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" gene 3791671..3792075 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" S_feature complement(3791692..3792744) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3792045..3792737 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" gene 3792045..3792737 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" CDS complement(3792777..3793808) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" gene complement(3792777..3793808) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" downshifts complement(3792789) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" promotor_-35 3793775..3793778 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3793791 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3793795..3793814 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3793845..3793863) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3793863) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" promotor_-35 complement(3793878..3793884) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3793901..3795049) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" gene complement(3793901..3795049) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" promotor_-10 complement(3795088..3795107) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3795099) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" promotor_-35 complement(3795118..3795125) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3795171..3795178 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3795192..3795211 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3795199 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" CDS 3795245..3795976 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" gene 3795245..3795976 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" CDS 3795969..3797510 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" gene 3795969..3797510 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" CDS 3797539..3798885 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" gene 3797539..3798885 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" promotor_-35 3798338..3798342 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3798358..3798377 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3798367 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" CDS 3798908..3800314 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" gene 3798908..3800314 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" downshifts 3800303 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" misc_feature 3800411..3800430 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3800413..3800704 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3800413 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" promotor_-35 3800677..3800684 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3800699..3800718 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3800706 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" promotor_-35 3800728..3800735 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3800750..3800769 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3800753) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3800756..3800770) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3800765 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" promotor_-35 complement(3800778..3800782) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3800778..3801341 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" gene 3800778..3801341 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" CDS 3801355..3802884 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" gene 3801355..3802884 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" downshifts complement(3802711) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" downshifts 3802877 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" S_feature complement(3802910..3802993) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3802953) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" CDS complement(3802994..3804433) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" gene complement(3802994..3804433) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" CDS complement(3804447..3804677) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" gene complement(3804447..3804677) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" S_feature complement(3804678..3804889) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3804886..3804905) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3804891) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" promotor_-35 complement(3804920..3804927) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3804953..3804960 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3804971..3804990 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3804986 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" CDS 3805021..3805731 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" gene 3805021..3805731 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" CDS 3805759..3805917 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" gene 3805759..3805917 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" downshifts 3805994 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" CDS complement(3806048..3806770) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" gene complement(3806048..3806770) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" downshifts complement(3806060) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" promotor_-35 3806671..3806674 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3806690..3806694 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3806705 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3806791..3807420) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" gene complement(3806791..3807420) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" S_feature complement(3807421..3807569) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3807570..3808328) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" gene complement(3807570..3808328) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" promotor_-10 complement(3808018..3808037) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3808034) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" promotor_-35 complement(3808050..3808057) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3808309..3809268) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" gene complement(3808309..3809268) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" downshifts 3809257 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" misc_feature 3809304..3809307 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3809312 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3809326..3809475) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" gene complement(3809326..3809475) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" downshifts complement(3809333) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" misc_feature 3809384..3809401 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3809389 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3809470 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(3809496..3809515) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3809517) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" promotor_-35 complement(3809530..3809537) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3809810..3809817 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3809832..3809851 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3809836 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" CDS 3809947..3811872 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" gene 3809947..3811872 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" S_feature 3811873..3813237 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3812085..3812405) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3812406..3814166) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" gene complement(3812406..3814166) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" downshifts complement(3812449) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" misc_feature 3813234..3813235 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3813239 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3814166..3814564) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" gene complement(3814166..3814564) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" CDS complement(3814557..3816002) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" gene complement(3814557..3816002) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" promotor_-35 3815252..3815259 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3815271..3815290 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3815281..3816330 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3815281 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" S_feature complement(3816003..3816263) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3816264..3816743) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " gene complement(3816264..3816743) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" S_feature complement(3816744..3816823) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3816824..3816994) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" gene complement(3816824..3816994) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" promotor_-10 complement(3817035..3817054) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3817051) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" promotor_-35 complement(3817068..3817073) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3817117..3817124 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3817137..3817156 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3817154 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" CDS 3817179..3817592 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" gene 3817179..3817592 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" downshifts 3817572 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" CDS complement(3817626..3818852) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" gene complement(3817626..3818852) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" downshifts complement(3817641) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" promotor_-10 complement(3818875..3818893) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3818880) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" promotor_-35 complement(3818905..3818913) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3818915..3819085) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" gene complement(3818915..3819085) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" promotor_-10 complement(3819104..3819122) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3819122) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" promotor_-35 complement(3819136..3819142) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3819190..3819438) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" gene complement(3819190..3819438) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" CDS complement(3819454..3820617) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" gene complement(3819454..3820617) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" promotor_-10 complement(3819488..3819506) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3819496) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" promotor_-35 complement(3819518..3819526) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3820628..3821365) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" gene complement(3820628..3821365) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" promotor_-10 complement(3821407..3821425) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3821413) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" promotor_-35 complement(3821439..3821447) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3821507..3821977) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" gene complement(3821507..3821977) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" downshifts complement(3821520) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" S_feature complement(3821978..3822048) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3822009..3822015 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3822029..3822048 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3822030..3822049) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3822030 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" upshifts complement(3822048) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" S_feature complement(3822050..3822325) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3822064..3822071) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3822088..3823185 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" gene 3822088..3823185 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" promotor_-10 complement(3822316..3822334) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3822325) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" promotor_-35 complement(3822349..3822354) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3822909..3822917 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3822929..3822947 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3822942 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" CDS 3823186..3823302 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" gene 3823186..3823302 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" downshifts 3823291 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" CDS complement(3823539..3824429) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" gene complement(3823539..3824429) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" downshifts complement(3823545) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" downshifts complement(3823607) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" CDS complement(3824503..3825906) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" gene complement(3824503..3825906) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" S_feature complement(3825907..3826128) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3826129..3827334) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" gene complement(3826129..3827334) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" misc_feature complement(3827391..3827409) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3827394) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" promotor_-35 3827504..3827509 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3827524..3827543 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3827539 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" CDS 3827575..3828960 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" gene 3827575..3828960 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" CDS complement(3828942..3829130) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" gene complement(3828942..3829130) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo CDS complement(3829247..3829375) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" gene complement(3829247..3829375) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" downshifts 3829299 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" CDS complement(3829395..3830597) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" gene complement(3829395..3830597) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" downshifts complement(3829419) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3830629..3830640) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3830629) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" promotor_-35 complement(3830655..3830661) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3830679..3831473) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" gene complement(3830679..3831473) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" CDS complement(3831495..3832337) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" gene complement(3831495..3832337) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" CDS complement(3832324..3833691) /gene="walH" /locus_tag="BSU_40390" /old_locus_tag="BSU40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYNNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" gene complement(3832324..3833691) /gene="walH" /locus_tag="BSU_40390" /old_locus_tag="BSU40390" CDS complement(3833681..3835516) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" gene complement(3833681..3835516) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" CDS complement(3835524..3836231) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" gene complement(3835524..3836231) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" S_feature complement(3836232..3836328) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3836316..3836335) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3836328) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" S_feature complement(3836330..3836522) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3836351..3836354) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3836522) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" misc_feature complement(3836532..3836551) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3836614) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" tRNA complement(3836615..3836687) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3836615..3836687) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" tRNA complement(3836723..3836799) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3836723..3836799) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" S_feature complement(3836800..3836880) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3836881..3836952) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3836881..3836952) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" tRNA complement(3836962..3837037) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3836962..3837037) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" misc_feature 3837009..3837025 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3837022 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3837038..3837134) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3837118..3837137) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3837134) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" promotor_-35 complement(3837151..3837158) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3837168..3837268) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3837208) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" CDS complement(3837261..3838553) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" gene complement(3837261..3838553) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" downshifts complement(3837272) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(3838593..3838612) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3838613) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" promotor_-35 complement(3838627..3838634) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3838759..3839178) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" gene complement(3838759..3839178) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" promotor_-10 complement(3839176..3839187) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3839187) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" promotor_-35 complement(3839202..3839208) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3839299..3840663) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" gene complement(3839299..3840663) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" downshifts complement(3839319) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" downshifts complement(3839363) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3840694..3840713) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3840708) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" promotor_-35 complement(3840728..3840730) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3840775..3840781 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3840796..3840814 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3840798 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" CDS 3840833..3841033 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" gene 3840833..3841033 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" downshifts 3841003 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" S_feature 3841048..3841369 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3841081..3841284) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" gene complement(3841081..3841284) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" S_feature complement(3841285..3841585) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3841350..3841353 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3841368..3841387 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3841371 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" CDS 3841405..3841545 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" gene 3841405..3841545 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" S_feature 3841546..3841617 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3841593) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" promotor_-10 complement(3841596..3841610) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3841618..3841622) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3841618..3842826 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" gene 3841618..3842826 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" downshifts 3842807 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" CDS 3842931..3844988 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" gene 3842931..3844988 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" downshifts 3844853 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" CDS complement(3845025..3845474) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" gene complement(3845025..3845474) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" downshifts complement(3845039) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" CDS complement(3845471..3847450) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" gene complement(3845471..3847450) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" misc_feature complement(3845952..3845971) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3845955) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" promotor_-35 3846368..3846375 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3846389..3846407 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3846393..3847059 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3846393 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" CDS complement(3847487..3848416) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" gene complement(3847487..3848416) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" S_feature complement(3848417..3848553) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3848535..3848554) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3848553) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" promotor_-35 complement(3848569..3848574) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3848643..3848792) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" gene complement(3848643..3848792) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" downshifts complement(3848669) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3848831..3848850) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3848848) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" promotor_-35 complement(3848864..3848870) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3848871..3848880 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3848893..3848912 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3848899 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" upshifts complement(3848911) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3848913..3849426) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3848915..3848929) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3848938..3848942) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3848938..3849420 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" gene 3848938..3849420 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" downshifts 3849407 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" CDS complement(3849450..3849827) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" gene complement(3849450..3849827) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" S_feature 3849452..3849981 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3849471) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" promotor_-10 complement(3849882..3849901) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3849894) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" promotor_-35 complement(3849915..3849922) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3849963..3849967 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3849981..3850000 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3849983 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" promotor_-10 complement(3850008..3850022) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3850011) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3850032..3850961 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" gene 3850032..3850961 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" promotor_-35 complement(3850036) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3850947 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" downshifts complement(3850990) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" CDS complement(3850994..3851440) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" gene complement(3850994..3851440) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" S_feature complement(3851441..3851771) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3851630..3851747) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" gene complement(3851630..3851747) /gene="mswM" /locus_tag="BSU_misc_RNA_94" promotor_-10 complement(3851762..3851781) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3851770) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" promotor_-35 complement(3851795..3851802) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3851808..3851814 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3851827 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" promotor_-10 3851829..3851847 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3851843..3851849 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3851864..3851875 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3851871 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" CDS 3851873..3853180 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" gene 3851873..3853180 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" downshifts complement(3852981) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" downshifts 3853169 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" CDS complement(3853224..3853463) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" gene complement(3853224..3853463) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo downshifts complement(3853245) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3853249..3853349) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3853289) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3853453..3853617) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" gene complement(3853453..3853617) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo CDS complement(3853629..3853814) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" gene complement(3853629..3853814) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" downshifts 3853895 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" CDS complement(3854087..3854233) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" gene complement(3854087..3854233) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo CDS complement(3854215..3854364) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" gene complement(3854215..3854364) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo misc_feature complement(3854680..3854696) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3854697) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3854716..3854723 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3854738..3854941 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3854738..3854757 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3854738 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" misc_feature complement(3854759..3854773) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3854763) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" CDS 3854942..3855379 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" gene 3854942..3855379 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" S_feature 3855380..3855456 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3855413 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" CDS 3855493..3856248 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" gene 3855493..3856248 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" S_feature complement(3856088..3858678) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3856238..3856948 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" gene 3856238..3856948 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" downshifts 3856447 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" CDS 3856945..3857700 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" gene 3856945..3857700 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" CDS 3857697..3858353 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKIKKTTVLDNISYTFEKGTIYGLFGSNGSGKTMLL RALSGLIVPTEGSITIKGEQLHKDISFPKSVGLIIENMQLLPQYDAFTNLKILSKIKK IASDNDILDSISRVGLENFNSVKVSKFSLGMKQRLNIAQAIFEKPDILLLDEPTNAID EKGVAFVHDILLQEKKRGATIIITSHHKEDIISLCDIALEMNHGRLETSEKVIYKKDS *" gene 3857697..3858353 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" S_feature 3858354..3858668 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3858625 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" downshifts 3858669 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" downshifts complement(3858723) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" CDS complement(3858728..3859516) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" gene complement(3858728..3859516) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" promotor_-10 complement(3859540..3859558) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3859559) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" promotor_-35 complement(3859574..3859579) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3859584..3859973) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" gene complement(3859584..3859973) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" promotor_-35 3860042..3860045 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3860060..3860079 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3860073 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" CDS 3860119..3860958 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" gene 3860119..3860958 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" downshifts 3860935 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" CDS complement(3860991..3862205) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" gene complement(3860991..3862205) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" downshifts complement(3861009) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" S_feature complement(3862206..3862309) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3862302..3862321) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3862310..3862317 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3862312) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" promotor_-10 3862331..3862350 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3862335..3862342) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3862343 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" CDS 3862392..3863270 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" gene 3862392..3863270 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" CDS 3863284..3863727 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" gene 3863284..3863727 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" CDS 3863810..3864289 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " gene 3863810..3864289 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" downshifts 3864279 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" CDS complement(3864464..3865126) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" gene complement(3864464..3865126) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" CDS complement(3865273..3865725) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" gene complement(3865273..3865725) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" promotor_-35 3865749..3865756 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3865771..3865790 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3865773 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" S_feature 3865775..3865844 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3865778..3865797) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3865780) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" promotor_-35 complement(3865810..3865817) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3865845..3866291 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" gene 3865845..3866291 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" CDS 3866288..3866893 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" gene 3866288..3866893 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" CDS complement(3866988..3867509) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" gene complement(3866988..3867509) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" S_feature complement(3867510..3868337) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3867558..3867565 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3867579 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3867580..3867599 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3867645..3867919 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3867645 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" promotor_-35 3867648..3867653 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3867666..3867685 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3867920..3868276 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" gene 3867920..3868276 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" S_feature 3868277..3868435 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3868319..3868338) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3868337) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" promotor_-35 complement(3868353..3868360) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3868436..3869002 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" gene 3868436..3869002 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" CDS complement(3869509..3870885) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" gene complement(3869509..3870885) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" CDS complement(3870919..3870981) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" gene complement(3870919..3870981) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" promotor_-10 complement(3871002..3871021) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3871021) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" promotor_-35 complement(3871034..3871041) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3871169..3871175 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3871191..3871210 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3871197 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" CDS 3871234..3871473 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" gene 3871234..3871473 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" downshifts 3871482 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" promotor_-35 3871566..3871573 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3871589..3871608 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3871605 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" CDS 3871624..3872040 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" gene 3871624..3872040 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" CDS 3872037..3872954 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" gene 3872037..3872954 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" misc_feature 3872981..3873000 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3872991 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" promotor_-10 complement(3872995..3873014) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3873001) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3873026..3875095 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" gene 3873026..3875095 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" promotor_-35 complement(3873028..3873035) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3875059 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" CDS complement(3875092..3875991) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" gene complement(3875092..3875991) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" downshifts complement(3875135) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3876020..3876039) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3876036) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" S_feature complement(3876038..3877269) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3876054..3876061) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3876132..3876139 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3876153..3876172 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3876159 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" CDS 3876217..3877572 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" gene 3876217..3877572 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" promotor_-10 complement(3877255..3877274) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3877279) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" promotor_-35 complement(3877288..3877297) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3877606..3878160) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" gene complement(3877606..3878160) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" CDS complement(3878178..3878558) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" gene complement(3878178..3878558) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" CDS complement(3878614..3879549) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" gene complement(3878614..3879549) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" promotor_-35 3879539..3879548 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3879562..3879581 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3879569 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3879593..3879612) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3879607) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" CDS complement(3879608..3880366) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" gene complement(3879608..3880366) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" promotor_-35 complement(3879625..3879632) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3879899..3880402 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3880361 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" CDS complement(3880431..3880670) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" gene complement(3880431..3880670) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" downshifts complement(3880437) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" downshifts complement(3880505) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" CDS complement(3880714..3881232) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" gene complement(3880714..3881232) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" CDS complement(3881273..3881560) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" gene complement(3881273..3881560) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" S_feature complement(3881561..3881627) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3881626..3881645) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3881627) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" promotor_-35 complement(3881659..3881664) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3881671..3882771) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" gene complement(3881671..3882771) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" promotor_-10 complement(3882819..3882838) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3882834) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" promotor_-35 complement(3882853..3882860) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3882898..3884901) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" gene complement(3882898..3884901) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" CDS complement(3884952..3885158) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" gene complement(3884952..3885158) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" promotor_-10 complement(3885120..3885139) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3885145) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3885154..3885160) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3885184..3885203) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3885195) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" promotor_-35 complement(3885220..3885224) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3885252..3886268) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" gene complement(3885252..3886268) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" promotor_-10 complement(3886301..3886319) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3886313) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" promotor_-35 complement(3886335..3886340) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3886444) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" promotor_-35 3886628..3886633 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3886646..3886727 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3886646 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" promotor_-10 3886649..3886667 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3886728..3887345 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" gene 3886728..3887345 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" promotor_-35 3887316..3887324 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3887335 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" promotor_-10 3887338..3887356 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3887357 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3887384..3888232) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" gene complement(3887384..3888232) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" downshifts complement(3887404) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" CDS complement(3888225..3888986) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" gene complement(3888225..3888986) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" misc_feature complement(3889020..3889039) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3889038) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" upshifts complement(3889130) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" promotor_-10 complement(3889133..3889141) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3889155..3889163) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3889167..3889175 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3889183 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" promotor_-10 3889187..3889205 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3889234..3889674 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" gene 3889234..3889674 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" downshifts 3889623 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" CDS complement(3889725..3890576) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" gene complement(3889725..3890576) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" downshifts complement(3889744) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" S_feature complement(3890577..3890697) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3890698..3891417) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" gene complement(3890698..3891417) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" CDS complement(3891431..3893317) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" gene complement(3891431..3893317) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" CDS complement(3893338..3894717) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" gene complement(3893338..3894717) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" S_feature complement(3894718..3894848) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3894840..3894859) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3894848) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" promotor_-35 complement(3894875..3894879) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3894903..3894922) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3894913) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" promotor_-35 complement(3894936..3894943) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3895003..3895009 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3895014..3897299 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3895014 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" promotor_-10 3895024..3895043 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3895028..3895654) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" gene complement(3895028..3895654) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" downshifts complement(3895045) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" CDS complement(3895651..3896436) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" gene complement(3895651..3896436) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" promotor_-10 complement(3896481..3896500) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3896493) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" S_feature complement(3896495..3896580) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3896512..3896518) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3896581..3896931) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" gene complement(3896581..3896931) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" S_feature complement(3896932..3897082) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3897083..3897217) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" gene complement(3897083..3897217) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" promotor_no_box 3897241..3897341 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3897253..3897272) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3897263) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" S_feature complement(3897265..3897333) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3897288..3897295) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3897301..>3897434 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3897301 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" promotor_-10 complement(3897319..3897338) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3897333) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" promotor_-35 complement(3897354..3897358) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" ORIGIN 1 atctttttcg gcttttttta gtatccacag aggttatcga caacattttc acattaccaa 61 cccctgtgga caaggttttt tcaacaggtt gtccgctttg tggataagat tgtgacaacc 121 attgcaagct ctcgtttatt ttggtattat atttgtgttt taactcttga ttactaatcc 181 tacctttcct ctttatccac aaagtgtgga taagttgtgg attgatttca cacagcttgt 241 gtagaaggtt gtccacaagt tgtgaaattt gtcgaaaagc tatttatcta ctatattata 301 tgttttcaac atttaatgtg tacgaatggt aagcgccatt tgctcttttt ttgtgttcta 361 taacagagaa agacgccatt ttctaagaaa aggagggacg tgccggaaga tggaaaatat 421 attagacctg tggaaccaag cccttgctca aatcgaaaaa aagttgagca aaccgagttt 481 tgagacttgg atgaagtcaa ccaaagccca ctcactgcaa ggcgatacat taacaatcac 541 ggctcccaat gaatttgcca gagactggct ggagtccaga tacttgcatc tgattgcaga 601 tactatatat gaattaaccg gggaagaatt gagcattaag tttgtcattc ctcaaaatca 661 agatgttgag gactttatgc cgaaaccgca agtcaaaaaa gcggtcaaag aagatacatc 721 tgattttcct caaaatatgc tcaatccaaa atatactttt gatacttttg tcatcggatc 781 tggaaaccga tttgcacatg ctgcttccct cgcagtagcg gaagcgcccg cgaaagctta 841 caacccttta tttatctatg ggggcgtcgg cttagggaaa acacacttaa tgcatgcgat 901 cggccattat gtaatagatc ataatccttc tgccaaagtg gtttatctgt cttctgagaa 961 atttacaaac gaattcatca actctatccg agataataaa gccgtcgact tccgcaatcg 1021 ctatcgaaat gttgatgtgc ttttgataga tgatattcaa tttttagcgg ggaaagaaca 1081 aacccaggaa gaatttttcc atacatttaa cacattacac gaagaaagca aacaaatcgt 1141 catttcaagt gaccggccgc caaaggaaat tccgacactt gaagacagat tgcgctcacg 1201 ttttgaatgg ggacttatta cagatatcac accgcctgat ctagaaacga gaattgcaat 1261 tttaagaaaa aaggccaaag cagagggcct cgatattccg aacgaggtta tgctttacat 1321 cgcgaatcaa atcgacagca atattcggga actcgaagga gcattaatca gagttgtcgc 1381 ttattcatct ttaattaata aagatattaa tgctgatctg gccgctgagg cgttgaaaga 1441 tattattcct tcctcaaaac cgaaagtcat tacgataaaa gaaattcaga gggtagtagg 1501 ccagcaattt aatattaaac tcgaggattt caaagcaaaa aaacggacaa agtcagtagc 1561 ttttccgcgt caaatcgcca tgtacttatc aagggaaatg actgattcct ctcttcctaa 1621 aatcggtgaa gagtttggag gacgtgatca tacgaccgtt attcatgcgc atgaaaaaat 1681 ttcaaaactg ctggcagatg atgaacagct tcagcagcat gtaaaagaaa ttaaagaaca 1741 gcttaaatag caggaccggg gatcaatcgg ggaaagtgtg aataactttt cggaagtcat 1801 acacagtctg tccacatgtg gataggctgt gtttcctgtc tttttcacaa cttatccaca 1861 aatccacagg ccctactatt acttctacta ttttttataa atatatatat taatacatta 1921 tccgttagga ggataaaaat gaaattcacg attcaaaaag atcgtcttgt tgaaagtgtc 1981 caagatgtat taaaagcagt ttcatccaga accacgattc ccattctgac tggtattaaa 2041 attgttgcat cagatgatgg agtatccttt acagggagtg actcagatat ttctattgaa 2101 tccttcattc caaaagaaga aggagataaa gaaatcgtca ctattgaaca gcccggaagc 2161 atcgttttac aggctcgctt ttttagtgaa attgtaaaaa aattgccgat ggcaactgta 2221 gaaattgaag tccaaaatca gtatttgacg attatccgtt ctggtaaagc tgaatttaat 2281 ctaaacggac tggatgctga tgaatatccg cacttgccgc agattgaaga gcatcatgcg 2341 attcagatcc caactgattt gttaaaaaat ctaatcagac aaacagtatt tgcagtgtcc 2401 acctcagaaa cacgccctat cttgacaggt gtaaactgga aagtggagca aagtgaatta 2461 ttatgcactg caacggatag ccaccgtctt gcattaagaa aggcgaaact tgatattcca 2521 gaagacagat cttataacgt cgtgattccg ggaaaaagtt taactgaact cagcaagatt 2581 ttagatgaca accaggaact tgtagatatc gtcatcacag aaacccaagt tctgtttaaa 2641 gcgaaaaacg tcttgttctt ctcacggctt ctggacggga attatccaga cacaaccagc 2701 ctgattccgc aagacagcaa aacagaaatc attgtgaaca caaaagaatt ccttcaggcc 2761 attgatcgtg catctctttt agctagagag ggacgcaaca acgttgtaaa actgtccgca 2821 aaaccggctg aatccattga aatttcttcc aattcgccag aaatcggtaa agttgtggaa 2881 gcaattgttg cggatcaaat tgaaggtgag gaattaaata tctcttttag tccaaaatat 2941 atgctggatg cactaaaggt gcttgaagga gcagaaatac gcgtaagctt tacaggcgca 3001 atgagacctt tcttaattcg cacgccgaat gatgaaacga ttgtacagct tatccttcct 3061 gtcagaacct attaatccga tacactgctg ccgacccgtc ggcagctttt ctattcggta 3121 tctgctccga caagttttcc ctttccctaa ttcgtttttt tttagtacaa ttagatatta 3181 gtgatatttg aaagaggtcg atataatggc aaatccgatt tcaattgata cagagatgat 3241 tacactcgga caattcttaa aattagccga tgtgattcag tctggcggta tggcgaagtg 3301 gtttttaagc gagcatgaag tgcttgtgaa cgatgagccg gacaaccgcc ggggcagaaa 3361 gctgtatgtt ggagatgtgg tagagattga aggatttggt tcatttcaag tcgtcaatta 3421 aagcgggtga cactgattgt atatccagaa cttagaactg acatcttacc gcaactacga 3481 ccatgctgaa cttcaatttg aaaataaagt aaatgtgatc atcggagaaa acgcccaggg 3541 gaagacaaac ctcatggagg cgatctatgt cttgtccatg gcgaaatcgc accggacatc 3601 aaatgacaaa gaacttatac ggtgggacaa agactatgct aaaatagagg gaagagtgat 3661 gaagcaaaac ggggcgatcc cgatgcagct cgtcatctcc aaaaagggta aaaagggcaa 3721 ggtcaatcat attgaacagc aaaagctcag ccagtatgtc ggggccctca acaccattat 3781 gttcgcgccg gaagatttaa atcttgtaaa gggaagccct caagtgagaa ggcggtttct 3841 tgacatggaa atcggacagg tttctcccgt ctaccttcat gatctttctc tttaccagaa 3901 aatcctttcc cagcggaatc attttttgaa acagctgcaa acaagaaaac aaactgaccg 3961 gacgatgctc gatgttctga ccgatcagct tgtagaagtt gcagcaaaag tcgtcgtaaa 4021 acgcctgcag tttacagcac agctcgagaa atgggcgcag cccatccatg caggcatctc 4081 aagagggctt gaagaactga ccctgaaata ccatacagct cttgatgtat cagatcccct 4141 agatttgtcg aaaataggag atagctatca agaagcgttt tctaaattaa gagaaaaaga 4201 aattgagcgt ggtgtgacgc tgtcagggcc tcatcgcgat gatgttcttt tctatgtgaa 4261 cggacgcgat gtgcagacgt atggttctca aggacagcag cgaacgacgg cgttgtccct 4321 taagctggcg gagattgacc tgatccatga agaaatcgga gaatatccca ttttactatt 4381 ggatgatgta ctgagtgaac tggatgatta tcgccagtca cacttgcttc atacgatcca 4441 aggccgtgta caaacgtttg tcacaacgac aagcgttgat ggcattgatc acgaaacctt 4501 acgtcaagca ggaatgttcc gtgtgcaaaa tggtgcgtta gtgaagtgaa gaaatgaggt 4561 gagcaattgt atattcattt aggtgatgac tttgtggttt caacacgaga tattgtcggc 4621 atttttgact ttaaagccaa catgtcgcct attgttgaag aatttctgaa aaaacagaaa 4681 cacaaggtgg tgccttccgt aaacggcacg cccaaatcta tcgtagtcac ggttcagaat 4741 atatattact ctcccttatc ttccagcaca ttaaaaaaac gtgcgcaatt tatgtttgaa 4801 atagattctt agaaattttt tatcacgaat atatcgttta gaaaagtgta ggtgaatgac 4861 gtggctatgg aacagcagca aaacagttat gatgaaaatc agatacaggt actagaagga 4921 ttggaagctg ttcgtaaaag accggggatg tatatcggtt cgacaaacag caaaggcctt 4981 caccacttgg tatgggaaat tgtcgacaat agtattgacg aagccctcgc cggttattgt 5041 acggatatca atatccaaat cgaaaaagac aacagtatca cggttgtaga taatggccgc 5101 ggtattccag tcggtattca tgaaaaaatg ggccgtcctg cggtagaagt cattatgacg 5161 gtgcttcatg ccggaggaaa atttgacgga agcggctata aagtatccgg aggattacac 5221 ggtgtaggtg cgtcggtcgt aaacgcacta tcaacagagc ttgatgtgac ggttcaccgt 5281 gacggtaaaa ttcaccgcca aacctataaa cgcggagttc cggttacaga ccttgaaatc 5341 attggcgaaa cggatcatac aggaacgacg acacattttg tcccggaccc tgaaattttc 5401 tcagaaacaa ccgagtatga ttacgatctg cttgccaacc gcgtgcgtga attagccttt 5461 ttaacaaagg gcgtaaacat cacgattgaa gataaacgtg aaggacaaga gcgcaaaaat 5521 gaataccatt acgaaggcgg aattaaaagt tatgtagagt atttaaaccg ctctaaagag 5581 gttgtccatg aagagccgat ttacattgaa ggcgaaaagg acggcattac ggttgaagtg 5641 gctttgcaat acaatgacag ctacacaagc aacatttact cgtttacaaa caacattaac 5701 acgtacgaag gcggtaccca tgaagctggc ttcaaaacgg gcctgactcg tgttatcaac 5761 gattacgcca gaaaaaaagg gcttattaaa gaaaatgatc caaacctaag cggagatgac 5821 gtaagggaag ggctgacagc gattatttca atcaaacacc ctgatccgca gtttgagggc 5881 caaacaaaaa caaagctggg caactcagaa gcacggacga tcaccgatac gttattttct 5941 acggcgatgg aaacatttat gctggaaaat ccagatgcag ccaaaaaaat tgtcgataaa 6001 ggtttaatgg cggcaagagc aagaatggct gcgaaaaaag cgcgtgaact aacacgccgt 6061 aagagtgctt tggaaatttc aaacctgccc ggtaagttag cggactgctc ttcaaaagat 6121 ccgagcatct ccgagttata tatcgtagag ggtgactctg ccggaggatc tgctaaacaa 6181 ggacgcgaca gacatttcca agccattttg ccgcttagag gtaaaatcct aaacgttgaa 6241 aaggccagac tggataaaat cctttctaac aacgaagttc gctctatgat cacagcgctc 6301 ggcacaggta tcggagaaga cttcaacctt gagaaagccc gttaccacaa agttgtcatt 6361 atgacagatg ccgatgttga cggcgcgcac atcagaacac tgctgttaac gttcttttac 6421 agatatatgc gccaaattat cgaaaatggc tacgtgtaca ttgcgcagcc gccgctctac 6481 aaggttcaac aggggaaacg cgttgaatat gcatacaatg acaaggagct tgaagagctg 6541 ttaaaaactc ttcctcaaac gcctaagcct ggactgcagc gttacaaagg tcttggtgaa 6601 atgaatgcca cccagctatg ggagacaacc atggatccta gctccagaac acttcttcag 6661 gtaactcttg aagatgcaat ggatgcggat gagacttttg aaatgcttat gggcgacaag 6721 gtagaaccgc gccgaaactt catagaagcg aatgcgagat acgttaaaaa tcttgacatc 6781 taatcataaa aagccttatt tccaataaga aataaggctt ttttctgaac aagatcagat 6841 gcagcgatgc ctgcaatacc tatatattct agcaatttaa tgtgtataat cataagttta 6901 ttgatataat ggagaatagt gaaatcgtat tgaaggtcat aatggacaat ctactcccac 6961 atatttcatg tgatacttca gggaggtttt ttaatgagtg aacaaaacac accacaagtt 7021 cgtgaaataa atatcagtca ggaaatgcgt acgtccttct tggattatgc aatgagcgtt 7081 atcgtgtccc gtgctcttcc ggatgttcgt gacggtttaa aaccggttca tagacggatt 7141 ttgtatgcaa tgaatgattt aggcatgaca agtgacaagc cttataaaaa atccgcgcgt 7201 atcgttggag aagttatcgg gaaataccac ccgcacggtg attcagcggt atatgaatcc 7261 atggtcagaa tggctcagga tttcaactac cgttatatgc tcgttgacgg tcacggaaac 7321 ttcggttctg ttgacggaga ctcagcggcg gccatgcgtt atacagaagc acgaatgtct 7381 aaaatctcaa tggagattct tcgcgacatc acaaaagaca caatcgatta ccaggataac 7441 tatgacgggt cagaaagaga acctgtcgtt atgccttcaa ggttcccgaa tctgctcgtg 7501 aacggtgctg ccggcattgc ggtaggtatg gcaacaaaca ttcctccgca ccagctggga 7561 gaaatcattg acggtgtact tgctgttagt gagaatccgg acattacaat tccagagctt 7621 atggaagtca ttccagggcc tgatttcccg accgcgggtc aaatcttggg acgcagcggt 7681 atccggaaag catacgaatc aggccgaggc tctatcacga tccgggcaaa agctgagatc 7741 gaacaaacat cttcgggtaa agaaagaatt atcgttacag agttacctta ccaagtaaat 7801 aaggcgaaat taattgagaa aattgctgat ctcgtaaggg acaaaaagat agagggtatc 7861 acagatctgc gtgatgagtc agatcgtaca ggtatgagaa ttgtcattga aatcagacgc 7921 gatgccaatg cgaatgttat cttaaacaat ctgtacaaac aaactgctct acaaacatct 7981 tttggcatca acctgcttgc gcttgttgat ggccagccga aagttttaac tcttaagcaa 8041 tgcctggagc attaccttga ccatcaaaaa gttgtcatta gacgccgtac tgcttatgaa 8101 ttgcgtaaag cagaagcgag agctcatatc ttggaaggat tgagagttgc actggatcat 8161 ctcgatgcag ttatctccct tatccgtaat tctcaaacgg ctgaaattgc gagaacaggt 8221 ttaattgaac aattctcact gacagagaag caagcacaag cgatccttga catgaggctc 8281 cagcgtttaa cgggactgga acgtgaaaag atcgaagaag aataccagtc tcttgttaaa 8341 ttaattgcag agctaaaaga catcttggca aatgaatata aagtgcttga gatcattcgt 8401 gaagaactca cggaaatcaa agagcgtttt aacgatgaaa gacgtactga gatcgtcact 8461 tctggactgg agacaattga agatgaagat ctcatcgaga gagaaaatat cgtagttact 8521 ctgacgcaca acggatacgt caaacgtctt cctgcatcaa cttaccgcag tcaaaaacgg 8581 ggcggaaaag gtgtacaagg tatgggaaca aacgaagatg atttcgttga acatttgatc 8641 tctacgtcaa ctcatgacac gattctcttc ttctcgaaca aggggaaagt gtatcgtgca 8701 aaagggtatg aaatccctga atacggcaga acggcaaaag gaatcccgat tattaacctg 8761 ctggaggtag aaaagggtga gtggatcaac gcgattattc cagtcacgga attcaatgcg 8821 gagctttacc tcttcttcac tacaaagcat ggggtttcaa aacgaacatc gctatctcaa 8881 ttcgctaata tccgcaacaa tggtctaatt gctctgagtc ttcgtgaaga tgatgaactg 8941 atgggtgtac gtctgactga cggcacaaaa caaatcatca ttggaacgaa aaacggttta 9001 ctgattcgtt tccctgaaac agatgtccga gagatgggaa gaactgcggc gggcgtaaaa 9061 ggcatcaccc tgacggatga cgacgttgtt gtcggcatgg agattttaga ggaagaatca 9121 cacgtcctta tcgtaactga aaaagggtac ggaaaacgaa ctcctgctga agagtacaga 9181 acccaaagcc ggggcggaaa aggactcaaa acagcgaaaa tcaccgagaa caacggccaa 9241 ctagtagcag tgaaagctac taaaggtgaa gaggatctaa tgattattac agctagcggc 9301 gtactcatca gaatggacat caatgatatc tccatcaccg gacgtgtcac tcaaggtgtg 9361 cgtctcatca gaatggcaga agaagagcat gttgctacag tagctttagt tgagaaaaac 9421 gaagaagatg agaatgaaga agaacaagaa gaagtgtgaa aaaaagcgca gctgaaatag 9481 ctgcgctttt ttgtgtcata accctttaca gtcataaaaa ttatggtata atcatttctg 9541 ttgtcttttt aaagacacaa gcatgaccat tatgactagt aaaaactttt tcaaaaaagt 9601 attgacctag ttaactaaaa atgttactat taagtagtcg ctttgagaga agcacacaaa 9661 gttctttgaa aactaaacaa gacaaaacgt acctgttaat tcatttttat aaatcgcaca 9721 gcgatgtgcg tagtcagtca aactagggcc tgcacgacgc aggtcacaca ggtgtcgccg 9781 caggatgcgg tgaacttaac ctgtgatcca tttatcggag agtttgatcc tggctcagga 9841 cgaacgctgg cggcgtgcct aatacatgca agtcgagcgg acagatggga gcttgctccc 9901 tgatgttagc ggcggacggg tgagtaacac gtgggtaacc tgcctgtaag actgggataa 9961 ctccgggaaa ccggggctaa taccggatgg ttgtttgaac cgcatggttc aaacataaaa 10021 ggtggcttcg gctaccactt acagatggac ccgcggcgca ttagctagtt ggtgaggtaa 10081 cggctcacca aggcgacgat gcgtagccga cctgagaggg tgatcggcca cactgggact 10141 gagacacggc ccagactcct acgggaggca gcagtaggga atcttccgca atggacgaaa 10201 gtctgacgga gcaacgccgc gtgagtgatg aaggttttcg gatcgtaaag ctctgttgtt 10261 agggaagaac aagtgccgtt cgaatagggc ggtaccttga cggtacctaa ccagaaagcc 10321 acggctaact acgtgccagc agccgcggta atacgtaggt ggcaagcgtt gtccggaatt 10381 attgggcgta aagggctcgc aggcggtttc ttaagtctga tgtgaaagcc cccggctcaa 10441 ccggggaggg tcattggaaa ctggggaact tgagtgcaga agaggagagt ggaattccac 10501 gtgtagcggt gaaatgcgta gagatgtgga ggaacaccag tggcgaaggc gactctctgg 10561 tctgtaactg acgctgagga gcgaaagcgt ggggagcgaa caggattaga taccctggta 10621 gtccacgccg taaacgatga gtgctaagtg ttagggggtt tccgcccctt agtgctgcag 10681 ctaacgcatt aagcactccg cctggggagt acggtcgcaa gactgaaact caaaggaatt 10741 gacgggggcc cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg cgaagaacct 10801 taccaggtct tgacatcctc tgacaatcct agagatagga cgtccccttc gggggcagag 10861 tgacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca 10921 acgagcgcaa cccttgatct tagttgccag cattcagttg ggcactctaa ggtgactgcc 10981 ggtgacaaac cggaggaagg tggggatgac gtcaaatcat catgcccctt atgacctggg 11041 ctacacacgt gctacaatgg acagaacaaa gggcagcgaa accgcgaggt taagccaatc 11101 ccacaaatct gttctcagtt cggatcgcag tctgcaactc gactgcgtga agctggaatc 11161 gctagtaatc gcggatcagc atgccgcggt gaatacgttc ccgggccttg tacacaccgc 11221 ccgtcacacc acgagagttt gtaacacccg aagtcggtga ggtaaccttt taggagccag 11281 ccgccgaagg tgggacagat gattggggtg aagtcgtaac aaggtagccg tatcggaagg 11341 tgcggctgga tcacctcctt tctaaggata ttttacggaa tataagacct tgggtcttat 11401 aaacagaacg ttccctgtct tgtttagttt tgaaggaact ttgttccttg aataagttaa 11461 gatgggcctg tagctcagct ggttagagcg cacgcctgat aagcgtgagg tcggtggttc 11521 gagtccactc aggcccacca tcttatataa cggggcctta gctcagctgg gagagcgcct 11581 gctttgcacg caggaggtca gcggttcgat cccgctaggc tccaccaacg tgttctttga 11641 aaactagata acagtagaca tcacattcaa ttagtaacac aagatatcac atagtgattc 11701 tttttaacgg ttaagttaga aagggcgcac ggtggatgcc ttggcactag gagccgatga 11761 aggacgggac gaacaccgat atgcttcggg gagctgtaag caagctttga tccggagatt 11821 tccgaatggg gaaacccacc actcgtaatg gagtggtatc catatctgaa ttcataggat 11881 atgagaaggc agacccgggg aactgaaaca tctaagtacc cggaggaaga gaaagcaaat 11941 gcgattccct gagtagcggc gagcgaaacg ggatcagccc aaaccaagag gcttgcctct 12001 tggggttgta ggacactctg tacggagtta caaaggaacg aggtagatga agaggtctgg 12061 aaaggcccgc cataggaggt aacagccctg tagtcaaaac ttcgttctct cctgagtgga 12121 tcctgagtac ggcggaacac gtgaaattcc gtcggaatcc gggaggacca tctcccaagg 12181 ctaaatactc cctagtgacc gatagtgaac cagtaccgtg agggaaaggt gaaaagcacc 12241 ccggaagggg agtgaaagag atcctgaaac cgtgtgccta caagtagtca gagcccgtta 12301 acgggtgatg gcgtgccttt tgtagaatga accggcgagt tacgatctcg tgcaaggtta 12361 agcagaagat gcggagccgc agcgaaagcg agtctgaata gggcgcatga gtacgtggtc 12421 gtagacccga aaccaggtga tctacccatg tccagggtga agttcaggta acactgaatg 12481 gaggcccgaa cccacgcacg ttgaaaagtg cggggatgag gtgtgggtag gggtgaaatg 12541 ccaatcgaac ctggagatag ctggttctct ccgaaatagc tttagggcta gcctcaaggt 12601 aagagtcttg gaggtagagc actgattgga ctaggggccc ctaccgggtt accgaattca 12661 gtcaaactcc gaatgccaat gacttatcct tgggagtcag actgcgagtg ataagatccg 12721 tagtcgaaag ggaaacagcc cagaccgcca gctaaggtcc caaagtatac gttaagtgga 12781 aaaggatgtg gagttgctta gacaaccagg atgttggctt agaagcagcc accatttaaa 12841 gagtgcgtaa tagctcactg gtcgagtgac tctgcgccga aaatgtaccg gggctaaacg 12901 tatcaccgaa gctgcggact gttcttcgaa cagtggtagg agagcgttct aagggctgtg 12961 aagccagacc ggaaggactg gtggagcgct tagaagtgag aatgccggta tgagtagcga 13021 aagaggggtg agaatcccct ccaccgaatg cctaaggttt cctgaggaag gctcgtccgc 13081 tcagggttag tcgggaccta agccgaggcc gaaaggcgta ggcgatggac aacaggttga 13141 tattcctgta ccacctcctc accatttgag caatgggggg acgcaggagg atagggtaag 13201 cgcggtattg gatatccgcg tccaagcagt taggctggga aataggcaaa tccgtttccc 13261 ataaggctga gctgtgatgg cgagcgaaat atagtagcga agttcctgat tccacactgc 13321 caagaaaagc ctctagcgag gtgagaggtg cccgtaccgc aaaccgacac aggtaggcga 13381 ggagagaatc ctaaggtgat cgagagaact ctcgttaagg aactcggcaa aatgaccccg 13441 taacttcggg agaaggggtg ctctgttagg gtgcaagccc gagagagccg cagtgaatag 13501 gcccaggcga ctgtttagca aaaacacagg tctctgcgaa gccgtaaggc gaagtatagg 13561 ggctgacgcc tgcccggtgc tggaaggtta agaggagcgc ttagcgtaag cgaaggtgcg 13621 aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct 13681 tgtcgggtaa gttccgaccc gcacgaaagg cgcaacgatc tgggcactgt ctcaacgaga 13741 gactcggtga aattatagta cctgtgaaga tgcaggttac ccgcgacagg acggaaagac 13801 cccgtggagc tttactgcag cctgatattg aatgttggta cagcttgtac aggataggta 13861 ggagccttgg aaaccggagc gccagcttcg gtggaggcat cggtgggata ctaccctggc 13921 tgtattgacc ttctaacccg ccgcccttat cgggcgggga gacagtgtca ggtgggcagt 13981 ttgactgggg cggtcgcctc ctaaaaggta acggaggcgc ccaaaggttc cctcagaatg 14041 gttggaaatc attcgcagag tgtaaaggca caagggagct tgactgcgag acctacaagt 14101 cgagcaggga cgaaagtcgg gcttagtgat ccggtggttc cgcatggaag ggccatcgct 14161 caacggataa aagctacccc ggggataaca ggcttatctc ccccaagagt ccacatcgac 14221 ggggaggttt ggcacctcga tgtcggctca tcgcatcctg gggctgtagt cggtcccaag 14281 ggttgggctg ttcgcccatt aaagcggtac gcgagctggg ttcagaacgt cgtgagacag 14341 ttcggtccct atccgtcgcg ggcgcaggaa atttgagagg agctgtcctt agtacgagag 14401 gaccgggatg gacgcaccgc tggtgtacca gttgttctgc caagggcatc gctgggtagc 14461 tatgtgcgga cgggataagt gctgaaagca tctaagcatg aagcccccct caagatgaga 14521 tttcccattc cgcaaggaag taagatccct gaaagatgat caggttgata ggtctgaggt 14581 ggaagtgtgg cgacacatgg agctgacaga tactaatcga tcgaggactt aaccatattt 14641 ttgaatgatg tcacacctgt tatctagttt tgagagaaca ctctcaattt gtttggtggc 14701 gatagcgaag aggtcacacc cgttcccata ccgaacacgg aagttaagct cttcagcgcc 14761 gatggtagtc gggggtttcc ccctgtgaga gtaggacgcc gccaagcaag cttaaaccca 14821 gctcaatgag ctgggttttt tgtttgttaa aaatgaagaa gaaactgtga agcgtattta 14881 gggaatttct tttctgatac taataaaaac tgctgaatta acacgtagtc atcacttata 14941 tgctgtgtta ataactcata ccaccattct gtttcatacc ttgcaatcat cccaacgttg 15001 tacaaaatca aataatgaat tgtcatttcg ggaagcctca gaaattgctc cctttgagaa 15061 gggatataat attggttctt ttccatgtca aacaataagc tggtcgatgt ccatggctcc 15121 ttgtcttgtg gtgaaatttc gaacagcagc ccgtgttcat ttttttttgt aaaagaccat 15181 tgataatgat gggacatgta ttcagcaaac cttgaatcag acattttgta attgattact 15241 acttcctccg gtacaaaaat ttcgttctta tccttctcaa cttttgtcat aaatcgttct 15301 ttctgctgaa agtagaaaat atcgctaagt tctggaatgg ccattaataa ttttttcatg 15361 gtataccgtt catctactat atccgattgt ccgaataaat gtttcataaa atgtacgcat 15421 aggccattcc gttgtatttt cacttcatcg tcgctaaaac aataattttg tttctttcgt 15481 tttcttgttg ttacgccatg tgccagtact gatgtatggc ttggataatg aggatcacgt 15541 gtaattaagc atgctttgat aagctgtgcc attccataaa ataaaagaat cggtttgatt 15601 tctaagggag aatatgcggc ttgtttataa aacgattcgg catgctttaa gaaataaata 15661 aaccgttcac tgtttttaaa agagtttttt ttcgcatcgt taataccgtt taagatataa 15721 accttttcta gaaatttctg ggttgattca acggagtaaa atagcgctaa gtctttccac 15781 tcatgatatg tcatgtatat ttcttaatcc tttccgttat ctaaatattt caactctttc 15841 ccgcttcctt gacatgctct tggctagttg ataatctaca tataatattt tgccgaaaag 15901 agggggattt actaatgtgg gaaagtaaat tttcaaaaga aggcttaacg ttcgacgatg 15961 tgctgcttgt accagcaaag tctgaggtac ttccgcgtga tgtggattta tctgtagaac 16021 ttacaaaaac gttaaagcta aatattcctg tcatcagcgc aggtatggac actgtaacag 16081 aatcagcaat ggcaattgca atggcaagac agggcggctt gggcatcatt cacaaaaata 16141 tgtccattga acagcaggct gaacaagttg ataaagtaaa gcgttctgag cgcggcgtta 16201 tcacaaatcc cttcttttta actcctgatc accaagtatt tgatgcggag catttgatgg 16261 ggaaatacag aatttccggt gttccgattg taaataacga agaagaccag aagcttgttg 16321 gaattattac aaaccgtgac cttcgtttta tttctgacta ctcaatgaaa atcagcgacg 16381 tcatgacgaa agaagagcta gttactgcat ctgtaggaac tactctggat gaagctgaaa 16441 agattttgca gaaacataaa attgaaaagc ttcctctcgt agatgaccag aataaattaa 16501 aaggtcttat cacaattaaa gacattgaaa aagtcattga gttcccgaac tcatctaaag 16561 acattcacgg ccgcctgatc gttggcgcgg cagttggtgt aactggcgat acaatgactc 16621 gcgtcaaaaa gcttgttgaa gccaatgttg atgtgattgt tatcgataca gctcacggac 16681 actctcaagg cgttttaaac acagtcacaa aaatccgtga aacgtatccc gaattaaaca 16741 ttattgctgg aaacgtggca acagctgaag cgacaagagc gcttatcgaa gctggagcag 16801 acgttgtcaa agttggaata gggcctggtt caatttgtac tacacgtgtt gtagccggcg 16861 tgggtgttcc gcaaattaca gcaatttatg attgtgcgac tgaagcaaga aaacacggca 16921 aaacaatcat cgccgacggt gggattaaat tctctggcga tatcactaaa gcattggcag 16981 ccggcggaca tgctgttatg ctcggaagct tgcttgcagg cacatcagaa agccctggtg 17041 aaactgaaat ctaccaaggc agaagattta aggtataccg cggcatggga tcagttgctg 17101 caatggaaaa aggaagtaaa gaccgttact tccaagaaga aaacaaaaaa tttgttcctg 17161 aaggaattga aggacgcaca ccttacaaag ggccagttga agaaaccgtt tatcagctag 17221 tcggaggcct tcgttctggt atggggtatt gcgggtccaa agatctgcgt gcgctaagag 17281 aagaagctca gttcattcgc atgactggcg caggacttcg cgaaagccat ccgcatgacg 17341 tacagattac aaaagaatca cctaactata caatttcata ataaattgtt acaaattaaa 17401 aacatttgac agggtctctg actctgtcta ttttttttat actgattatg ataaaattta 17461 tactgttgtg cattgaaaat gtccttaacg gcttaattat agatgaagaa aatgaaatac 17521 ggaggtcgta cgattgaaca tcaagaaatg taaacagcta ctgatgtcat tggttgtgtt 17581 aactctagct gtcacgtgtc tggctccaat gtcaaaagcg aaagcagcca gcgatccaat 17641 tgatatcaat gcatctgctg ctattatgat cgaagcttct tcaggtaaaa ttctttacag 17701 taaaaatgca gataagagac tgccaattgc gagtatgaca aaaatgatga cagagtatct 17761 gttattggaa gcaattgatc aaggtaaagt gaaatgggac caaacctata cgcctgatga 17821 ctatgtgtat gaaatttccc aagataacag cttatcaaac gttcctcttc ggaaagacgg 17881 gaaatacaca gtaaaagaat tatatcaagc tacagcaatt tattctgcaa atgctgctgc 17941 tattgcgatt gcagaaatcg ttgccggttc tgaaactaag tttgttgaaa aaatgaatgc 18001 aaaagcaaaa gaactaggct taacagatta caaatttgtt aacgcaacag gtcttgaaaa 18061 caaagatctt cacgggcatc agcctgaggg gacaagcgta aatgaagaaa gtgaagtttc 18121 tgcaaaggat atggcggttc ttgcggatca cttgattact gactaccctg agatactgga 18181 gacttccagt atcgccaaaa cgaaattcag agaaggcacc gatgatgaaa tggacatgcc 18241 gaactggaat tttatgctga aggggcttgt cagcgagtat aaaaaagcga ctgtagacgg 18301 actgaaaaca ggttctactg actctgcggg ttcatgcttt acaggaacag ctgaacgcaa 18361 cggtatgcgt gtcatcactg ttgttttaaa cgcaaagggc aaccttcata caggccgttt 18421 cgatgaaacg aaaaaaatgt ttgattatgc tttcgacaat ttctccatga aagaaattta 18481 tgctgaaggc gatcaagtaa aaggccataa aacaatttca gttgataagg gtaaagagaa 18541 agaagtaggc attgtgacaa acaaggcgtt ctctcttcct gtcaaaaatg gtgaagaaaa 18601 gaattacaaa gcgaaggtca cactgaataa agacaactta actgctcctg tgaaaaaagg 18661 aaccaaggtt gggaagctga ctgcggaata cacaggtgat gaaaaggatt acggattcct 18721 taacagcgat ctggctggcg tagaccttgt tacaaaagaa aatgtagaaa aagcaaactg 18781 gtttgttttg acaatgcgca gtatcggcgg attttttgcc ggaatttggg gaagcattgt 18841 tgatacggta accggctggt tttaatcaat tgaaagagct ctgatggatg ttagggctct 18901 ttcgcgtaat atactgaaaa aacccaattt ttaataaaaa atgattttca aagcgctaaa 18961 aaccgaataa aatagtatat atgcatatga attattggat ttctaggata caataaggat 19021 tagaaatcat ataactatac cttgattagg gggaccaaga aatggctcaa acaggtactg 19081 aacgtgtaaa acgcggaatg gcagaaatgc aaaaaggcgg cgtcatcatg gacgtcatca 19141 atgcggaaca agcgaaaatc gctgaagaag ctggagctgt cgctgtaatg gcgctagaac 19201 gtgtgccagc agatattcgc gcggctggag gagttgcccg tatggctgac cctacaatcg 19261 tggaagaagt aatgaatgca gtatctatcc cggtaatggc aaaagcgcgt atcggacata 19321 ttgttgaagc gcgtgtgctt gaagctatgg gtgttgacta tattgatgaa agtgaagttc 19381 tgacgccggc tgacgaagaa tttcatttaa ataaaaatga atacacagtt ccttttgtct 19441 gtggctgccg tgatcttggt gaagcaacac gccgtattgc ggaaggtgct tctatgcttc 19501 gcacaaaagg tgagcctgga acaggtaata ttgttgaggc tgttcgccat atgcgtaaag 19561 ttaacgctca agtgcgcaaa gtagttgcga tgagtgagga tgagctaatg acagaagcga 19621 aaaacctagg tgctccttac gagcttcttc ttcaaattaa aaaagacggc aagcttcctg 19681 tcgttaactt tgccgctggc ggcgtagcaa ctccagctga tgctgctctc atgatgcagc 19741 ttggtgctga cggagtattt gttggttctg gtatttttaa atcagacaac cctgctaaat 19801 ttgcgaaagc aattgtggaa gcaacaactc actttactga ttacaaatta atcgctgagt 19861 tgtcaaaaga gcttggtact gcaatgaaag ggattgaaat ctcaaactta cttccagaac 19921 agcgtatgca agaacgcggc tggtaagaac ataggagcgc tgctgacatg ttaacaatag 19981 gtgtactagg acttcaagga gcagttagag agcacatcca tgcgattgaa gcatgcggcg 20041 cggctggtct tgtcgtaaaa cgtccggagc agctgaacga agttgacggg ttgattttgc 20101 cgggcggtga gagcacgacg atgcgccgtt tgatcgatac gtatcaattc atggagccgc 20161 ttcgtgaatt cgctgctcag ggcaaaccga tgtttggaac atgtgccgga ttaattatat 20221 tagcaaaaga aattgccggt tcagataatc ctcatttagg tcttctgaat gtggttgtag 20281 aacgtaattc atttggccgg caggttgaca gctttgaagc tgatttaaca attaaaggct 20341 tggacgagcc ttttactggg gtattcatcc gtgctccgca tattttagaa gctggtgaaa 20401 atgttgaagt tctatcggag cataatggtc gtattgtagc cgcgaaacag gggcaattcc 20461 ttggctgctc attccatccg gagctgacag aagatcaccg agtgacgcag ctgtttgttg 20521 aaatggttga ggaatataag caaaaggcac ttgtataaaa cagttgaaag ctgtggaaac 20581 ttatagtaca ttataagcac aaataaagat cgaaaagcgt tgataggaac tagtagggag 20641 cctctctttc taagagagcc gatggttggt gcgaatcggt gaaagatgct gtctgaatcc 20701 atccttgagc gaaatgctga agcgagtagg catttacggg ataaccgtta tgtttgaaag 20761 tggaaaacga gtctttgatt tgttttcaat cagggtggca acgcgagagc tctcgtccct 20821 ttatggggat gagggctctt tttattttcg ataaatcaat aaaaaaagga gtgtttcgca 20881 tgcttgatac gaaaatgctg agagcaaatt ttcaagaaat taaagcaaag cttgtacaca 20941 aaggcgaaga cttaactgat tttgataagt ttgaggcgct ggatgataga cgaagagagc 21001 ttatcggcaa ggttgaagag ttaaaaggaa aacgaaatga agtttctcag caggttgctg 21061 tgctgaagcg tgagaaaaaa gacgcggatc acattattaa agaaatgcgt gaagtcggcg 21121 aggaaattaa aaagctcgat gaagaattac ggacagtgga agctgagctt gatacaatcc 21181 tgctctcaat cccgaatatt ccgcatgagt ctgtacctgt cggtgaaaca gaagacgaca 21241 acgtagaagt gcgtaaatgg ggtgaaaagc cttcatttgc ttatgagccg aagccgcact 21301 gggatattgc ggatgagctg ggtattctgg attttgaacg tgctgccaaa gtaacaggaa 21361 gccgtttcgt gttctataaa ggcttaggtg ctcgtctgga gcgtgcgctt tataacttta 21421 tgcttgatct gcatgtggat gagtataact acactgaagt gatcccgcca tatatggtaa 21481 accgcgcaag catgacggga acggggcagc ttcctaaatt tgaagaggat gcatttaaaa 21541 tcagagaaga agattatttc ttaattccaa cggcggaagt gccgattaca aacatgcatc 21601 gcgatgaaat cctttcaggt gacagcctgc cgatcaacta tgcggcattc agtgcttgct 21661 tccgttctga agctggttca gcaggacgtg acacacgcgg attaattcgt cagcaccaat 21721 ttaataaagt tgagcttgta aagtttgtga agcctgaaga ttcttatgaa gaattagaga 21781 aacttacaaa ccaagcagaa cgggttcttc agctgcttga gcttccatac cgtgtcatga 21841 gcatgtgtac gggtgactta ggctttacgg ctgcgaaaaa atacgatatc gaagtttgga 21901 ttccaagcca agacacatat cgagaaatct cttcttgcag caacttcgaa gcgttccagg 21961 cgagacgtgc gaatattcgt ttcagacgtg aagcgaaagg caagcctgag catgtacaca 22021 cactgaacgg ctcaggactg gcggttggaa gaacagttgc tgctatctta gaaaattatc 22081 agcaggaaga cggaagcgtt gtgattccga aagtgcttcg tccttatatg gggaatagag 22141 aagtaatgaa accgtaaatt atggaaaggc gtgcctgaca aggtgcgcct ttttgcttat 22201 gtaaacacgg cattttcata aaaacaaaaa aagtttttaa aaatgcttga ccacacgaga 22261 acatacgtga tatagttagt cttgtcgata cggaggaata cccaagtccg gctgaaggga 22321 tcggtcttga aaaccgacag gggtgtcaaa gcccgcgggg gttcgaatcc ctcttcctcc 22381 gccatattga ttttaattct aatgaaacac aagcatatat tggagattgt tttgtccgtt 22441 gcattcggtg cggcggattt tttattttaa agaaaaagtg aatctcgact gagattcact 22501 ttttttgatt atcatgaata actgaagcaa tttgatctac aatattttca atcgagtttt 22561 cgtcgttcag aagatcataa tcttcaatgc gaagttttaa aacagggcag gcattaaaac 22621 cgcttatcca gttctcgtag cgtgtatgca tttcttccca ataagaccgg cttgtctgaa 22681 gctccatctc acggccgcgt tgttcaatcc ggtttaaaat gttctccaga tctccttcta 22741 aatagatcaa cacatctgga tgtgggaaat acggtgtcat taccattgct tcgaaaaggc 22801 ttgtgtaagt cttataatca acctttgaca ttgtcccttt atcagcatgc atttttgcga 22861 aaattcctgt atcttcataa atcgaacgat cctgtacaaa acctccgccg gcttcaaaaa 22921 ttgttttctg ttctttgaag cgttcagcta agaagtaaat ttgaaggtga aagctccaac 22981 gttcaaaatc atgatagaac ttttccaaat atggattatg atcgacttcc tccaacgatg 23041 ttttaaatcc aagccgttta gctaaagttt ttgttaaagt cgattttccg acacctactg 23101 ttcctgctac tgtaataatt gaattcttag ggatatgatg ttccttcata cgataagctc 23161 ctttacatgg gcggcaatgc gttcaaagtc gctcttattc aaaacgaaat cctttgaatc 23221 accatctacg gttaacactg taagttcagg gtctgcttcc tgcagctgct tgatggcgac 23281 ttcataatct gaaatcagct gctccaaata gctagtttca atttttttct caaaggggcg 23341 cccgcgtttt tcaatgcggt gtagcaatgt aggcagactg gcctttatgt aaatgatgaa 23401 attcggcttt ggcagatcat ccgttagcag gtgatatatc tttttgtatt tttccagctg 23461 atgtggagac aaggttcgtt ccgcaaaaat cacattttta taaatatgat aatcagctat 23521 tacaggctgt ccctttttta aaaagtgatc actggtgtct tcaagctgtt tgtatctgtg 23581 acaaagaaaa aacatctcga gctggaagct ccattccttt atattgtcat aaaacttatc 23641 aaggtacggg ttatcctcta caatctcatt gatcataggg aatccgaatt tttgtgagag 23701 catcgttgcg agagttgttt ttcctgcccc gataggacct tctattgcaa taaaaggggc 23761 tgtattcatc ggaatcctcc ttatatctga aaaacgtgcg tcagttaccg accttcatat 23821 tgtatcacaa cccttgggtg cccccatgaa aaaaagacgt ttccaaatta tcgaaacgtc 23881 tttttgacaa cattaaattg atcagacagc agcagccagt tttgtggaaa ggaaagaccc 23941 agcttccaat agctgatgcc tcttaaattc agctctttaa tcagattgaa ttttgcttga 24001 atcgagcggg catcctcgaa ccatacctcg tgccttctgt tttctgcatc agtatagcgg 24061 aagaaaggag cttgagcggt ttggtcatac tgaatggaag cattgttctg atcagctatg 24121 acaatggctt gctgagggct tactgctctt gctggagttc cccctgctgt atatggcagc 24181 gtccagtcat atccatataa attctggccc atgacaattt tgttcgcagg catttcagtc 24241 aaagcatatt ctatgacatc acggacaggt ccaattggag aaaccgcttg aggcggtccg 24301 ccgctatagc cccattcata tgtcatgaga acaacaaagt cgacaatttc gccatgtgcc 24361 ctgtaatcat gagcttcata ccacctgccc tgctgtgttg cacttgtttt aggagcaaga 24421 gccgtagaaa tttctaagcc ctctcgatgg aaaagatccc ttgcttcgcg gaggaattga 24481 ttataggcct ctctatcctg gggccgcaaa tattcaaagt cgaaatgaat gtcacggaag 24541 ccatatcttc tggcattctc gactatttca tttagaagcc gtctttttac agtttcgtcg 24601 ttcaaaagga tccggccaag ttcatcgctg aatgcctggt tttctaggtt cgttataatc 24661 atcatcaatg ttgtattttg actttctgta atgctcctta aattcgttaa aggcggtgcg 24721 actaaggttc cgttccgctg tgcctggaag ctgaatgcgc caaggtaagt taagtagggc 24781 gacgcttctc tggccgcctg ctggagattt tcgctgactt gatttcctcg gggctccaaa 24841 taagcatttg attcgatgtc tcgtttagga gctggaggga tgtataaacg gaaaccaatc 24901 tgaagcacgg tatttaactg gatgcggtta acccttgcga gctcggctgc tgttgtattg 24961 aactgccggg cgatggatgt cagggtatca cctcgcttca catcatagaa ctggccagct 25021 attggaatga caatggtttg tccgacaaca aggctgtcgg gattcggtat ttcattcgtt 25081 tcagtgatgt catttgtggt tgttctgtat tgtgaagcga tagcagaaag agtgtcgcct 25141 tgttttacca cataaatttg aatgaaaaac gcctcctttc atatcgctat caatgtatga 25201 aagaaaagcg ctgatcatgt ttatttttct ataatttgtt cttccgtcgt aatttctgcg 25261 aaaagaacat tctccatcat ggttaaggcg aattcgttat cttcgtcact gtttgacgcg 25321 atacagtcct taggaatcgt gatgctgtat tccctcatat aagcgtcatt agcggtaaac 25381 agcacgcata tattgccggc tatacctgtt atgataatat gtctcacctg caactcagta 25441 agaagggtgt gaagtgctgt ttcgtagaaa gcggaatgtt tcggtttgat taaaaaataa 25501 tcagcatcta ccggagctat ctttgtgatg atatccttgc ttctttcatt tgtgcattct 25561 tgctgtatgt ttttaatgtc agcttgccaa agtccataat gatcattgat gtaaataatc 25621 ggccattcat tttgtctcgc gtgctccttt aatgataaaa tatgaggaac gattttttct 25681 gtttttttag cgagggtttc ccccatatcg aattcaaaat tattgatcat gtctacaatg 25741 agaagggctt tatctgcttt ggacaatcga cagtctcctt tccgtttcag ttatagttaa 25801 tatgtagcct ttttaggcaa tgaaaaaact ttgaaaagag agcttatcct tatgacacaa 25861 gatgaacttt atatgaaaga agcaattaaa gaagcgaaaa aggctgaaga gaaaggtgaa 25921 gtgccaatag gtgcggtgct tgtcattaat ggtgaaatta tagcgcgtgc gcataattta 25981 agagagactg aacagcgatc tattgcccat gcagaaatgc ttgtaattga tgaagcgtgt 26041 aaggcactcg gaacatggcg gctggaaggt gcgactcttt atgtgacgct tgagccttgt 26101 ccaatgtgtg ctggtgcagt cgtactttct cgagtggaaa aagtggtttt tggcgcattt 26161 gatccgaaag gcggctgttc aggcacgcta atgaaccttc ttcaggagga acgctttaat 26221 catcaggctg aagtggtgag cggtgtgctt gaggaagaat gcggcggaat gctcagtgcg 26281 tttttcagag aactaagaaa aaagaagaaa gccgccagga aaaacttgtc tgaatagtac 26341 ggttgcaatt tttaggggaa acagatatac ttaagtgtgc atcgtaatag atgcaacata 26401 aaatttgata tttattttgc cgtgctaagc ggggaggtag cggtgccctg tacctgcaat 26461 ccgctctagc agggccgaat cccttctcga ggttcgttta ctttaaggcc tgccttaagt 26521 aagtggtgtt gacgtttggg tcctgcgcaa tgggaattca tgaaccatgt caggtccgga 26581 aggaagcagc attaagtgaa acctctcatg tgccgcaggg ttgcctgggc cgagctaact 26641 gcttaagtaa cgcttagggt agcgaatcga cagaaggtgc acggtaaatc aatcatcaaa 26701 ttttcagact cacctaatat taggtgagtt ttttgttatg taaaaagagc ttttggaatc 26761 gaaacaaggt tcatgtataa tgggaatgat gaataacgga ggagggcaaa cccgtgagtt 26821 accaagcttt atatcgagta ttcaggcctc agcgctttga agatgtggtc ggacaagaac 26881 acattacaaa aacgctgcaa aatgcccttt tgcaaaaaaa gttttctcac gcctatctgt 26941 tttccgggcc tagaggaacc ggaaaaacca gtgcagccaa aatatttgct aaggctgtca 27001 actgtgaaca tgctcctgtt gatgagccat gcaacgaatg tgcggcctgt aaagggataa 27061 caaacgggtc aatatccgat gtcatagaaa ttgacgccgc ttctaataac ggtgttgatg 27121 agattcgtga cattcgcgat aaagtgaagt ttgccccatc ggccgtcaca tataaggtat 27181 atatcataga tgaggtgcat atgctttcta tcggcgcttt taatgcatta ctaaaaacat 27241 tagaagagcc gcctgagcat tgtattttca tattagcaac aactgaaccg cacaaaattc 27301 ctttaaccat tatctctaga tgtcagcgtt ttgactttaa acgaattacc tcccaagcga 27361 ttgtaggccg catgaataaa attgttgatg ctgaacagct gcaagtggag gaaggatcgc 27421 tggaaatcat cgcgagtgct gcagacggag ggatgaggga tgccctgagc cttcttgatc 27481 aggccatatc attcagcggc gatatcctga aagtcgaaga tgcgctttta attacgggtg 27541 ctgtttctca attatatatc gggaagcttg caaaatccct gcatgataaa aacgtttctg 27601 acgcactgga aacattaaat gaattgcttc agcaaggaaa agatccagct aagctgatag 27661 aagatatgat tttctatttc agggacatgc tgctgtacaa aacagcccct ggcttagagg 27721 gagtgcttga gaaagtaaaa gtcgatgaaa cgttccggga actaagtgaa caaattccgg 27781 ctcaggccct atatgaaatg attgatattc tgaacaagag ccatcaggaa atgaaatgga 27841 caaatcatcc gcgtatcttt ttcgaagtgg ccgttgtgaa gatttgccaa acctcacatc 27901 aatctgctgc tgatctcccg gaagtggata tgctgatgaa aaaaatccag cagctcgaac 27961 aggaagtaga gcggctcaaa acaacgggca taaaagcagc tgcggaaagc ccgaaaaaag 28021 aagcgccgcg tgtgccaaag ggcgggaaat ccaattacaa agcgccagta ggcagaattc 28081 atgagatttt gaaggaagcc acaagaccgg atcttgatct gctcagaaac agttggggca 28141 agcttcttgc tcatctcaaa cagcaaaaca aagtatcaca tgccgctttg ctgaatgaca 28201 gtgaacctgt ggctgccgga tcggcggcat ttgttctgaa attcaaatat gaaattcatt 28261 gtaaaatggt cgctgaggat aacaacggag tccggactaa tcttgagcag attttagaat 28321 cgatgctcgg aaaaagaatg gatttgattg gcgttccaga agcacaatgg ggtaaaataa 28381 gagaagaatt tttagaagat catcagcagg aaaatgaagg atcaaatgaa ccggctgaag 28441 aagacccgct tattgccgaa gcgaaaaagc ttgttggagc ggatttaatt gaaataaaag 28501 actaacaaaa tgaaagagag tgaatgctat gcgtggcgga atgggtaata tgcaaaaaat 28561 gatgaaacaa atgcaaaaaa tgcaaaagga catggcgaag gctcaagaag agcttgcaga 28621 aaaggttgtt gaaggaactg caggcggcgg tatggtaaca gtaaaagcaa acggccaaaa 28681 agaaatcctg gatgttatca tcaaagaaga agtcgttgat cctgaagata ttgatatgct 28741 tcaagattta gtgcttgctg caacgaatga agctttgaaa aaagttgacg aaatcacaaa 28801 cgaaacaatg ggtcaattta caaagggaat gaacatgcca ggtttattct agggggataa 28861 aagaacatgc aatatcctga accaatatca aagctgattg acagctttat gaaattgcca 28921 gggatcggac cgaaaacagc ggttcgtctg gctttttttg ttctaggtat gaaagaagat 28981 gtagtattag attttgcgaa agcattagta aatgcgaaac gcaacctgac atattgttca 29041 gtttgcgggc atattacaga tcaggaccct tgctatatat gtgaagatac gcgcagggat 29101 aagtctgtta tctgtgttgt gcaagaccct aaagacgtta tcgctatgga gaaaatgaag 29161 gaatacaacg gacagtatca cgttcttcac ggcgctattt ctccaatgga cggcatcgga 29221 ccggaggata ttaaaatacc agaattgtta aaacgattac aggatgatca agtgacagaa 29281 gtgatcctcg cgacaaaccc taatatagaa ggggaagcaa cagcgatgta tatatcaagg 29341 ctcctcaagc cgtctggtat taagctctcc cgtattgccc acggactgcc cgtcggcggt 29401 gatttggaat atgctgatga ggtcactctt tctaaagcac ttgaaggaag acgtgaattg 29461 taaggaggaa aaagcgatcc atgggttttc ttcgcaagaa aacattaaga agagagtttg 29521 atgaaaaact aaccgagcag ctttttaagc aaaaggaaga gtggaacagg caaaaaaagc 29581 tggttgaaaa aagcttagaa ccgtctgctg aagtgttata cgaactgaaa gtagctgaag 29641 cgaagtattt tttttactta agggaagcga agcagcgaaa tttaaaaatc agccggtgga 29701 agtaagtggt ctaaactcct ggatcttctc ataagcttgt actagaacaa gcgaaggaga 29761 tgagaagatt catggagcct atttttatta ttgggattat tttaggactg gttattcttc 29821 tttttttatc aggttcagca gcgaagcctt taaagtggat tggcatcaca gctgttaaat 29881 ttgtggcagg tgctttgctg ctggtttgtg taaatatgtt tggcggcagt cttggcattc 29941 atgtgccgat taatctggtt acaacagcta tcagcggaat tttaggaata cccggaatag 30001 ctgcgttagt cgtcattaag caatttatca tttaattgat attatgtatt gacttagaca 30061 actgaaggtg ttattctaat atacgtcgct gatgacgaac agcttttttg aaaagaaaat 30121 gctaaaaagt tgttgacagt agcggcggta aatgttatga taataaagtc gcttaaacga 30181 gcggtaaaca aagttctttg aaaactaaac aagacaaaac gtacctgtta attcattttt 30241 ataaatcgca cagcaatgtg cgtagtcagt caaactactt tatcggagag tttgatcctg 30301 gctcaggacg aacgctggcg gcgtgcctaa tacatgcaag tcgagcggac agatgggagc 30361 ttgctccctg atgttagcgg cggacgggtg agtaacacgt gggtaacctg cctgtaagac 30421 tgggataact ccgggaaacc ggggctaata ccggatggtt gtttgaaccg catggttcaa 30481 acataaaagg tggcttcggc taccacttac agatggaccc gcggcgcatt agctagttgg 30541 tgaggtaacg gctcaccaag gcgacgatgc gtagccgacc tgagagggtg atcggccaca 30601 ctgggactga gacacggccc agactcctac gggaggcagc agtagggaat cttccgcaat 30661 ggacgaaagt ctgacggagc aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct 30721 ctgttgttag ggaagaacaa gtaccgttcg aatagggcgg taccttgacg gtacctaacc 30781 agaaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt 30841 ccggaattat tgggcgtaaa gggctcgcag gcggtttctt aagtctgatg tgaaagcccc 30901 cggctcaacc ggggagggtc attggaaact ggggaacttg agtgcagaag aggagagtgg 30961 aattccacgt gtagcggtga aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga 31021 ctctctggtc tgtaactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata 31081 ccctggtagt ccacgccgta aacgatgagt gctaagtgtt agggggtttc cgccccttag 31141 tgctgcagct aacgcattaa gcactccgcc tggggagtac ggtcgcaaga ctgaaactca 31201 aaggaattga cgggggcccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg 31261 aagaacctta ccaggtcttg acatcctctg acaatcctag agataggacg tccccttcgg 31321 gggcagagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 31381 gtcccgcaac gagcgcaacc cttgatctta gttgccagca ttcagttggg cactctaagg 31441 tgactgccgg tgacaaaccg gaggaaggtg gggatgacgt caaatcatca tgccccttat 31501 gacctgggct acacacgtgc tacaatggac agaacaaagg gcagcgaaac cgcgaggtta 31561 agccaatccc acaaatctgt tctcagttcg gatcgcagtc tgcaactcga ctgcgtgaag 31621 ctggaatcgc tagtaatcgc ggatcagcat gccgcggtga atacgttccc gggccttgta 31681 cacaccgccc gtcacaccac gagagtttgt aacacccgaa gtcggtgagg taacctttta 31741 ggagccagcc gccgaaggtg ggacagatga ttggggtgaa gtcgtaacaa ggtagccgta 31801 tcggaaggtg cggctggatc acctcctttc taaggatatt ttacggaata taagaccttg 31861 ggtcttataa acagaacgtt ccctgtcttg tttagttttg aaggaacttt gttccttgaa 31921 taagttaaga tgggcctgta gctcagctgg ttagagcgca cgcctgataa gcgtgaggtc 31981 ggtggttcga gtccactcag gcccaccatc ttatataacg gggccttagc tcagctggga 32041 gagcgcctgc tttgcacgca ggaggtcagc ggttcgatcc cgctaggctc caccaacgtg 32101 ttctttgaaa actagataac agtagacatc acattcaatt agtaacacaa gatatcacat 32161 agtgattctt tttaacggtt aagttagaaa gggcgcacgg tggatgcctt ggcactagga 32221 gccgatgaag gacgggacga acaccgatat gcttcgggga gctgtaagca agctttgatc 32281 cggagatttc cgaatgggga aacccaccac tcgtaatgga gtggtatcca tatctgaatt 32341 cataggatat gagaaggcag acccggggaa ctgaaacatc taagtacccg gaggaagaga 32401 aagcaaatgc gattccctga gtagcggcga gcgaaacggg attagcccaa accaagaggc 32461 ttgcctcttg gggttgtagg acactctgta cggagttaca aaggaacgag gtagatgaag 32521 aggtctggaa aggcccgcca taggaggtaa cagccctgta gtcaaaactt cgttctctcc 32581 tgagtggatc ctgagtacgg cggaacacgt gaaattccgt cggaatccgg gaggaccatc 32641 tcccaaggct aaatactccc tagtgaccga tagtgaacca gtaccgtgag ggaaaggtga 32701 aaagcacccc ggaaggggag tgaaagagat cctgaaaccg tgtgcctaca agtagtcaga 32761 gcccgttaac gggtgatggc gtgccttttg tagaatgaac cggcgagtta cgatcccgtg 32821 caaggttaag cagaagatgc ggagccgcag cgaaagcgag tctgaatagg gcgcatgagt 32881 acgtggtcgt agacccgaaa ccaggtgatc tacccatgtc cagggtgaag ttcaggtaac 32941 actgaatgga ggcccgaacc cacgcacgtt gaaaagtgcg gggatgaggt gtgggtaggg 33001 gtgaaatgcc aatcgaacct ggagatagct ggttctctcc gaaatagctt tagggctagc 33061 ctcaaggtaa gagtcttgga ggtagagcac tgattggact aggggcccct accgggttac 33121 cgaattcagt caaactccga atgccaatga cttatccttg ggagtcagac tgcgagtgat 33181 aagatccgta gtcgaaaggg aaacagccca gaccgccagc taaggtccca aagtatacgt 33241 taagtggaaa aggatgtgga gttgcttaga caaccaggat gttggcttag aagcagccac 33301 catttaaaga gtgcgtaata gctcactggt cgagtgactc tgcgccgaaa atgtaccggg 33361 gctaaacgta tcaccgaagc tgcggactgt tcttcgaaca gtggtaggag agcgttctaa 33421 gggctgtgaa gccagaccgg aaggactggt ggagcgctta gaagtgagaa tgccggtatg 33481 agtagcgaaa gaggggtgag aatcccctcc accgaatgcc taaggtttcc tgaggaaggc 33541 tcgtccgctc agggttagtc gggacctaag ccgaggccga aaggcgtagg cgatggacaa 33601 caggttgata ttcctgtacc acctcctcac catttgagca atggggggac gcaggaggat 33661 agggtaagcg cggtattgga tatccgcgtc caagcagtta ggctgggaaa taggcaaatc 33721 cgtttcccat aaggctgagc tgtgatggcg agcgaaatat agtagcgaag ttcctgattc 33781 cacactgcca agaaaagcct ctagcgaggt gagaggtgcc cgtaccgcaa accgacacag 33841 gtaggcgagg agagaatcct aaggtgatcg agagaactct cgttaaggaa ctcggcaaaa 33901 tgaccccgta acttcgggag aaggggtgct ctgttagggt gcaagcccga gagagccgca 33961 gtgaataggc ccaggcgact gtttagcaaa aacacaggtc tctgcgaagc cgtaaggcga 34021 agtatagggg ctgacgcctg cccggtgctg gaaggttaag aggagcgctt agcgtaagcg 34081 aaggtgcgaa ttgaagcccc agtaaacggc ggccgtaact ataacggtcc taaggtagcg 34141 aaattccttg tcgggtaagt tccgacccgc acgaaaggcg caacgatctg ggcactgtct 34201 caacgagaga ctcggtgaaa ttatagtacc tgtgaagatg caggttaccc gcgacaggac 34261 ggaaagaccc cgtggagctt tactgcagcc tgatattgaa tgttggtaca gcttgtacag 34321 gataggtagg agccttggaa accggagcgc cagcttcggt ggaggcatcg gtgggatact 34381 accctggctg tattgacctt ctaacccgcc gcccttatcg ggcggggaga cagtgtcagg 34441 tgggcagttt gactggggcg gtcgcctcct aaaaggtaac ggaggcgccc aaaggttccc 34501 tcagaatggt tggaaatcat tcgcagagtg taaaggcaca agggagcttg actgcgagac 34561 ctacaagtcg agcagggacg aaagtcgggc ttagtgatcc ggtggttccg catggaaggg 34621 ccatcgctca acggataaaa gctaccccgg ggataacagg cttatctccc ccaagagtcc 34681 acatcgacgg ggaggtttgg cacctcgatg tcggctcatc gcatcctggg gctgtagtca 34741 gtcccaaggg ttgggctgtt cgcccattaa agcggtacgc gagctgggtt cagaacgtcg 34801 tgagacagtt cggtccctat ccgtcgcggg cgcaggaaat ttgagaggag ctgtccttag 34861 tacgagagga ccgggatgga cgcaccgctg gtgtaccagt tgttctgcca agggcatcgc 34921 tgggtagcta tgtgcggacg ggataagtgc tgaaagcatc taagcatgaa gcccccctca 34981 agatgagatt tcccattccg caaggaagta agatccctga aagatgatca ggttgatagg 35041 tctgaggtgg aagtgtggcg acacatggag ctgacagata ctaatcgatc gaggacttaa 35101 ccacattttg aatgatgtca cacctgttat ctagttttga gagaacacct ctctaaaggc 35161 ggaaggtaag gaaactccgc taagggctct cacatcctgt gagaaacgcc cagtaccttc 35221 atcctgaagg catttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 35281 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 35341 acgccgccaa gcaagcttaa acccagctta atgagctggg ttttttgttt actcaagatc 35401 gagaaaatca aacaaataca aacaccgagg gcttatatag cccatatact gatttaaagt 35461 ttcaaaaagg tctaaatagt gtatacaata tccgttttaa ggggaggcta actgtacgga 35521 ggtggagaag atggacgaaa cagttaaact taatcataca tgtgtgattt gtgatcaaga 35581 gaagaataga ggcattcatc tttatacgaa attcatatgc ttagattgtg agagaaaagt 35641 aatttctaca tcaacttctg atcctgacta tgcgttttac gtaaaaaaac taaagagcat 35701 tcatacaccg ccattatatt catagacctg aaaaggtctt tttttgtact cttaataata 35761 aaaagaagat gaaacttgtt taaggattga acgtagtaga taataatatt aaaactgagt 35821 atagacacag gagtcgatta tctcatgcag agattttttc actttttggt gtggagttta 35881 actagcagtg cgacttttgt tttcattgga atattgagct tttttggttt aaaccagtcg 35941 atttttttat ctattgttta tgggcttgct tctggagcag ccgtatatat agctggcatc 36001 tggaatgcaa gacggttatt tcttaaaaag catgaattga caggaagaga gtatgcttac 36061 attaagaaaa acttagagga agcaaggcag aaaatggtcc gtcttaggaa agccttgttt 36121 caggctaaaa gcattcaaat gtttaagcaa aatgcagaaa tgctaaggat tgtgagaagg 36181 atttatctcc tcaccaaaaa agagccaaag cggttttatc aggcagaacg atttttttat 36241 caaactctcg attcggttgt tgaattgaca gagaagtatg cttttctatc atctcaccca 36301 aaaaaaagca aagaactgtc gatgtcgtta agtgagacac gcatcactct tactgaattg 36361 accaagcgtt tagaggaaga tttaactcaa gcaatgggtg atgaaattga cgagttgcag 36421 tttgaattag acgcagcaaa acattcatta aagaaataag ggaagagggt aagagcgatg 36481 aaccgagacc aaagcgacct tcatatagat gaattattgg cagatccttt tggtggtaac 36541 atagagatac caggttcgga ggctgtaaaa gcagagaaag agcaagtacg gcttgttgat 36601 gttcttcctg aggaaaacaa ggaaaaagca attcagcttg ctggacagat tgatcataaa 36661 aatatgcaaa gcattgtctt atacggttca caagctcaat ctaaactgct gaacttttct 36721 catgatatga ttaatcatgt tcaaaagaag gatgtcgggg agattggcga aatacttgga 36781 gagctgatga aaaagctgga gcaagtaaat cctgatgatc tccaatctaa gaaaaagggt 36841 tttttggcac gcatgtttgg aagagtatca agttctcttc aagaggtgct gtctaaatac 36901 caaaagacca gtgtgcagat agacagaatc agcttgaagc tggagcactc taaaaatgct 36961 ttaatcagtg acaacaagct gttagagcag ttatatgaaa aaaataaaga atatttcgca 37021 gcgctgaatg tttatattgc tgcaggagaa ctgaagctgg aggaattaaa aacaaaaacg 37081 attcctgaac tgaagcaaca ggctgaatcg agtgatcata accaaatggc cgttcaagag 37141 gtgaatgatt taattcaatt tgctgaccgg ttagataaaa gggtgcatga tttgctgctg 37201 agcaggcaaa ttacaatcca aagtgcaccg caaatcaggc tgattcaaaa tacaaaccaa 37261 gcgttagctg aaaagattca gtcatccatt gtgacagcga ttccgttatg gaaaaatcaa 37321 gttgccattg cactgacgct tttaaggcag cgcaatgcag tggatgcaca gcagaaagta 37381 tctgatacaa ccaatgagct tttgctgaaa aatgcggagc ttttaaaaac caatacaatt 37441 gaaactgcac gggcaaatga aagaggcctt gttgatatag ataccttgaa gaaggtgcag 37501 gaaagcttaa taagcacgct tgaagaaaca ctgactatac aagaagaagg acgaatcaaa 37561 cgccgtcagg cagaagaaga gctcatgatg atggaaggcg acctgaagca aaagctgatt 37621 acaataaagg aaagatgatt accagtaagt ctggctttaa gttctgtcag aggcacgata 37681 taataaggtg taagaagaca cattcaaagg attgttttca tgaacacacc tttatataaa 37741 gcattaattc aacatgcgag aagaaattct cattcatttc atgttccggg acatcacaat 37801 ggagatgtct tttttgatga cgctaagtca atattcgatc cgcttctcac cattgatgta 37861 actgaactgg caggactgga tgatctccat catccttctg gggtgattaa ggaagctcag 37921 gagcttgcca gtcaattata tggatcggcg gaaagttttt ttctggtaaa tggtacgact 37981 gtcggaaact tagcgatgat tttatctgtt tgtgaacctg gtgatacaat tctggttcaa 38041 agaaactgtc ataaatctgt atttcatgct gttgatttgt ccggtgctga gccggtttat 38101 cttgcacctg acgttgattc agcgatgcat gtgcctacgc atgttccgct tggaacaatt 38161 aaagaggccc tggaagcata tccagatgcg aaaggcttgg tactgaccaa tccgacatat 38221 tacggacata gtgctgattt gactgagatc attactgaag cccatcatta cgggattcct 38281 gttttggtcg atgaagcgca tggcgcacat tttattttag gtgagccttt tccggtctca 38341 gctttaaaaa tgggggcaga tattgttgtt cagtcggccc acaaaacgtt gccagccatg 38401 acgatgggtt cttatttgca tctcaacagc agctgcagga ttaacaggga tcgggtggca 38461 gagtatttaa accgattaca aagcagcagc ccgtcttatc cgattatggc ttcgttagat 38521 attgcccgcg cttatgtaca gcatattata gaagaacaaa agctttctga cattctgcag 38581 cggatagaaa cacttaaaca aacgtttgat tcacttacaa atgcagaagc tgttaaccct 38641 gctaatccac tgatcatcac ggatccgcta aagctcacaa ttcgttcaaa acgcgggcat 38701 tctggctata cgctgcaaag cattttagag cgtgccaaca tattcactga gcttgctgat 38761 gaaaatcaag ttctgctcgt tctcccattg ggaggaaaac ggagaataaa cgctgaaatc 38821 attagaagca tcgatgaaga gattgagaaa acgcctccgg atcagacgtt tgtttctgca 38881 gaatggggtg tgcagcctgt tactgtcttg ccttatccaa aaaaggtctt acattcgttt 38941 aagaaagaat atgtgagctt tgaggaagca gctggccggc ttaatgcaga agatatcatc 39001 ccttatcctc cgggtatccc gatgattatg gcgggagaaa gaataacaaa agaaagtgtg 39061 caaaagctca gccgcttgat cagcatgaaa acgcatgttc aagggaatat gaaaatcaaa 39121 gagaaacaac tacttgttta tatagaagag gagaaatcat gagcggttta tttattacat 39181 tcgaaggtcc tgaaggtgca gggaaaacga ctgttctgca ggagatcaaa aacatactga 39241 cagcagaagg ccttcaggtt atggcaactc gagagccagg cggaatagat attgcagaac 39301 aaattagaga ggttattctg aatgagaaca atatattaat ggacccaaaa acagaagctc 39361 tcttatatgc ggctgcaaga cgccagcatt tagttgaaaa agtaaaacct gctttagaac 39421 aggggtttat cgttctttgc gacagattca tagacagttc tcttgcgtat caaggatatg 39481 caagagggct tggaattgat gaggttctgt ccattaatga atttgccatt ggagatatga 39541 tgccccatgt aacggtttat ttttcaattg atccggaaga aggactgaag cgtatttacg 39601 caaacggctc acgggagaaa aacaggctcg atttagaaaa actggacttt catacaaaag 39661 tacaagaagg ttatcaagag ctgatgaagc gatttccgga aagatttcat tcagttgatg 39721 ccgggcaatc caaagacctc gtcgttcagg atgttctaaa ggtgatcgat gaagcgttga 39781 aaaaaattca attgtgacct gtttcccaat agttgatata ataatgtaaa cgagatcacg 39841 ttgtttccaa tctaaaggag gccttcacag atgaaattga tagtggcagt tgtacaagat 39901 caggacagca acagactttt gaaaacctta acggatcaca acttcagagt cacaaagctt 39961 gcaacgacag gaggatttct taaatcaggc aatacaacgt ttatgatcgg tgtcgaggat 40021 atacgcgtca ataaagcgtt gagtctcatt aaagaaaacg ggcagaaacg tgatcagatg 40081 attgcccctg tatctccaat gggtggaaat gctgattcct atgtccctta tccagtcgaa 40141 gttgaagttg gcggagcgac agtatttgtc cttccagtcg atgaatttca tcaattttaa 40201 ggatctgaaa ctgtgaaaat taataaagat atacgtacat ttatagataa taagcagatt 40261 ccctctgtga aaacatctga gatcacagca tcgtttaaaa catcaatgga aaaccaaagc 40321 agcaaaatga agcttgatca gcttaccagg ctgttatctg atatagaagc atttggaaaa 40381 aggctaacga aatctcggaa ttttaaagac ttagcgagat ttaaaggact tgtgaaacgt 40441 tttgtcaaag aagctgtgga cagcggtctt tcacatgaaa catcgaaaag ctttgacctt 40501 tacgggaaca gcagaacgct gggacttgtg aaagaaatag atgacaaatt gatacagctt 40561 acggaagaga tgatggatca ggaaaaaccg gcaattgatt tgctggagcg tattggcgaa 40621 ataaaaggtt tattaattaa cctttacaca tagagagtga tacaatggca atatcctgga 40681 aggaaatgaa cgagcttcag cccagagtga tgaagctttt atataatagt attgagaagg 40741 acagactatc acacgcttat ttgtttgagg ggaaaaaagg aacaggcaag cttgatgccg 40801 cgctgcttct tgcaaaaagc ttcttttgtc tggagggtgg cgcggagcct tgtgagagct 40861 gccgaaactg taaacggata gagtcaggga accatcctga tctccatctt gttcagcctg 40921 atggcttatc aatcaaaaag gcgcaaattc aagcgctcca agaagagttt tctaagacag 40981 gacttgaatc gcataaaaag ctgtatatta tttcgcacgc agatcaaatg acagcaaatg 41041 cggcgaacag cctgctgaaa tttttagaag aaccgaacaa agacacaatg gccgtcctca 41101 tcactgagca gccccaaagg ttattggata ccatcatttc aagatgccaa acccttcctt 41161 ttcagccttt gcagccgaaa gcaattgaag acagactgat cgaacaggac gtctcgcctc 41221 atatggcaag gcttctggcc aacatgacta ataatgtagc agaagcagtc gaattaagtc 41281 gaaatgatga gtttgcagag tctagagcga aagtgataaa attgtatgaa gtcctacacc 41341 agcggaaagg acatgctttt ttctttattc aagatcaatg gatgcccttt ttcaaagaaa 41401 aaacccatca agaaatgggt cttgatatgc tcttattgat atatcgtgat gtgttgtcca 41461 tccaaatagg aaatgaagat aaattgattt atcaagactt attccaatca ataaaacagc 41521 atgcgctaca atcaacacaa caaagcgtta cgaatcagat acttgctgtt ttagaagcaa 41581 agaaacggct tcattccaat gtgaatgtac aaggattaat ggagcacttg gtgttaatgt 41641 tgcaggaggg ataagcttgt acaatgtaat tggtgtccgc tttaagaaag cgggtaaaat 41701 atattatttt gatccgaatg gatttcatat agaacatgac agctgcgtaa ttgtagaaac 41761 tgtcagaggc gttgagtacg gccaggtcgt aattgcaaat aaacaggtgg atgagcatga 41821 tgtggtgctt ccccttcgaa aagtgatacg tgtggcagac gatcgcgatc ttctcattgt 41881 agaagaaaat aaacaggaag cactatcagc atttgatatc tgccaaaaga aagtgattga 41941 gcatggcttg gatatgaagc tggtcgatgt tgaattcacg tttgatcgca ataaagtcat 42001 tttttacttc actgctgacg gccgagtcga ctttagagag cttgtaaagg atttggcttc 42061 tatctttaag acaagaattg agctgcgcca aatcggagtg agggatgagg caaaaatgct 42121 cggaggaatc ggtccttgcg gaagaatgct ttgctgttca acgtttcttg gagattttga 42181 acccgtttcc attaaaatgg ccaaggatca gaacttgtct ttaaatccta cgaagatttc 42241 gggtctttgc ggacgattga tgtgctgtct aaaatatgag aacgatgagt atgagacggc 42301 aaaagaacag cttccggata taggagaaat gattacgaca gcaaacggtc ccgcgaaggt 42361 cgtcggacta aatattctgg aacgggtgct tcaggtggaa ctgataaacc gtgaaaaagt 42421 gatagaatat acttgggaag agctcttgga agagggcgtc gtatccgcac aaaccacaga 42481 ttaacgaggt gtggaacctt ggataaaaaa gagttatttg atacagtcat taacttagaa 42541 gaacaaattg gctcactgta ccggcagctg ggggatttga agcagcatat cggtgagatg 42601 attgaggaaa atcatcattt acagcttgaa aacaagcatt tgcgcaaacg gctggacgat 42661 acgacgcagc agattgaaaa gttcaaagct gataaaaaag aatcaaaaac acagaagaca 42721 gagcaaactg atatagggga aggatatgat aatctggcac gtctgtatca agaaggattt 42781 catatctgca atgtccacta tggaagtgtt cgaaaagagg attgtctttt ctgtctgtca 42841 ttcttaaata aaaaataggg aaaaggcttc cgcataagac gggagccttt ttcaaaggta 42901 ctgaaaggat aagaagatgg tttcattaca tgatgatgaa agattagatt atttgctggc 42961 agaggacatg aaaatcatac aaagcccaac agtgtttgct ttttcgttgg acgctgtgct 43021 tctgtccaaa tttgcgtacg ttccgattca aaaagggaaa attgttgatt tatgcaccgg 43081 caatggtatt gtgccgctgc tgctcagtac aagatcaaaa gcagacattc tgggagtcga 43141 aattcaagaa agactgcatg atatggctgt tcgcagcgtg gagtataata agttggacga 43201 tcagatccag atcatacatg atgacctgaa aaacatgccg gagaaacttg gacataatcg 43261 atatgatgtt gtcacctgca atccgccgta ttttaaaacg ccgaaacaaa ctgaacaaaa 43321 catgaacgag catctccgaa tcgcaagaca tgaaatccac tgcacgctgg aggatgtcat 43381 ttcagtcagc agcaagctgc tcaagcaagg gggaaaagca gctcttgttc accggccggg 43441 aaggcttctg gagatttttg aactgatgaa ggcttatcaa atcgagccga aacgtgtaca 43501 atttgtctat ccgaagcaag ggaaagaagc caataccatt ttggttgaag gtatcaaagg 43561 cgggcgcccg gatttgaaaa ttcttcctcc cttattcgta tatgatgaac aaaatgaata 43621 tacaaaagaa atcaggacca ttttatatgg agacaaataa ccatttcttc tacgtcgtga 43681 aatgtaagga caatagctgg tatgccgggt ataccaacga tctgcataaa cgagtgaaaa 43741 cgcacaatga tggaaagggc gcaaagtaca caaaagtaag acgtccggtt gaattaattt 43801 ttgccgagag cttttcaaca aagcgggaag ctatgcaggc ggaatattat ttcaaaaaac 43861 taactcggaa gaaaaaagag ctttatatag aagaaaagcg gaacagcaag gaggctgtat 43921 atgttaaggc gccaaatgag ctttaatgga aagtcggaca tggggattct ttacttggtc 43981 ccaaccccaa tcggaaattt agaggatatg acattccggg cgatcgacac gctgaaatca 44041 gtggatgcga ttgctgcgga agatacgagg caaacgaaaa agctttgtca tgtatatgaa 44101 attgaaacac cgctcgtcag ctatcacgaa cacaataaag aaagcagtgg gcacaaaatt 44161 attgaatggc tgaaatcggg aaaaaacatt gctcttgtca gtgatgccgg tctgccgacg 44221 atttctgatc ccggagcgga aattgtaaag gattttacgg atataggcgg ttatgttgtt 44281 ccgttgccgg gagcaaatgc tgcattaaca gctcttattg cttcaggtat tgtaccgcag 44341 ccttttttct tttacggttt tctcaacaga cagaaaaaag aaaagaagaa ggagcttgaa 44401 gcccttaaaa aacggcagga aacgatcatt ttttatgaag cgccccacag attgaaggaa 44461 accttgtcag cgatggcaga gatattagga gatcgggaaa ttgctgtaac acgtgaactc 44521 actaagaaat atgaagagtt tatccgagga accatatctg aggtcattgg atgggcaaac 44581 gaggatcaga tacgcggcga gttttgtctt gtcgtagaag gaagtaataa tgaagaggta 44641 gatgaggaag aacaatggtg ggaaaccctc actgcgaaag aacatgtcga gcattacatt 44701 tcgaaaggcg ctacgtctaa agaagctatt aaaaaagcag cagtcgatcg caatgtacca 44761 aagcgtgaag tgtacgatgc ttaccatatt aagcaataaa aaaacgttct tgtgtcataa 44821 caagaacgtt ttttgtacaa gaaatgatta tttaaggttt tgaagctggt tttggatttc 44881 gctgatgatt tgctcagcgc cttctttact aagaaccaat ttaccgcctg caagtttaag 44941 gttatcatca gaaacttcac cagttacttg gcaagtcatg tttggtttat attttttaag 45001 gatgattttt tcatcatcaa catagatttc aagagcatct ttttctgcga ttccaagagt 45061 acgacgcagt tcgataggaa taactacacg tcctaattca tcaactttac gtacaatacc 45121 agtagatttc ataaacattc tcctcccaag agatacttat ttgtttaaat tatatttttc 45181 ttcgtcatta ttcgacaaaa tccttacctt catagcataa caaggtttcc aataatcgtc 45241 aatcattttg tttactattg attgtaagaa ttagttctta tagtcagtaa tgtcttggaa 45301 actaccgaaa taacagcatt ttataaatat ttaataaagc tattatccta ctaaaaatcc 45361 ttttaaatca agactttcga accaaagttt tttatttcat ttgattatat acgacaaaat 45421 tcgacacgaa cagacttttt ttattttcat taaagatttt taattttaat tattcttttt 45481 cagggcgtat gtatatattc ttgatcttaa aggctaagat ggtatcatag ataaaggata 45541 aatataaata atattcatat atgatttgca cttatcgccg ctctcgtcct ttgggcggga 45601 gctttttgac attctgatta ggaggtttca agatgccgca agaaaacaat acattttaca 45661 ttacaacacc gatttattat ccgagcggaa aattacatat cggccatgca tatacgacag 45721 tcgcaggaga tgcaatggca cgttacaaaa gattaaaagg gttcgatgtt cgctatttaa 45781 cgggaacgga cgagcatgga caaaagatcc agcaaaaagc tgaacaggaa aacattacac 45841 ctcaggagta tgtggatcgc gcagcggcag atattcaaaa actgtggaag cagcttgaaa 45901 tctcaaacga cgactttatc cgcacgacag aaaaacggca taaagttgtc attgaaaaag 45961 tgtttcaaaa gcttcttgat aacggggaca tctatcttga tgagtatgaa ggctggtaca 46021 gcatccctga tgaaacgttc tacacggaaa ctcagctcgt tgatattgag cggaatgaaa 46081 agggagaggt catcggcgga aaaagccctg acagcggtca cccagttgaa ttgatcaaag 46141 aggaatctta tttcttccgc atggggaaat acgcggatcg tcttctgaaa tactatgaag 46201 aaaacccgac attcattcag ccagaatcac gcaaaaacga aatgattaat aactttatca 46261 aacctggact tgaggatttg gcagtatcac gtaccacttt tgattggggc gtgaaggtgc 46321 cggaaaatcc aaagcatgtt gtatatgttt ggattgacgc actatttaac tatttaacgg 46381 cactcggtta tgatacagaa aatgatgagc tttatcaaaa atattggcct gccgatgttc 46441 atttagtcgg taaggagatt gtacgattcc atactattta ctggccaatt atgctgatgg 46501 cgctggatct tccgctgcca aagcaagtat tcgcgcatgg ctggcttttg atgaaagacg 46561 gaaaaatgtc gaaatcaaaa ggaaacgttg tagatccggt tacattaatt gaacgctatg 46621 gtttagacga acttcgctat tacttgcttc gcgaagtgcc gttcggatca gacggtgttt 46681 tcacgccgga aggatttgtt gagcgaatca actatgattt agcgaatgat ttaggaaatc 46741 tattgaatcg tactgttgcg atgattaata agtattttga cggacaaatc ggttcttaca 46801 aaggtgctgt tacggaattt gaccatacgc tcacttctgt tgctgaagaa acagtgaaag 46861 cttatgagaa agcaatggaa aatatggagt tctcggtagc actttcgact ttatggcagc 46921 tcatcagccg cacaaacaaa tacattgatg agacagctcc atgggtgctt gcgaaagatc 46981 cggcaaaaga agaagaattg cgatcagtta tgtatcatct cgctgaatca ttgcgtattt 47041 cagcggtact gcttcagcca ttcttaacaa aaacacctga aaaaatgttc gagcagctgg 47101 gcattactga tgaatcttta aaagcttggg acagcattac agctttcggc cagctgaaag 47161 atacaaaagt acaaaaaggc gagccattgt tccctcgttt agaggcagaa gaagaaattg 47221 cttacatcaa agggaaaatg caaggttcag caccagcgaa agaagaaaca aaagaagaag 47281 agcctcaaga ggtcgatcgt ttacctgaaa ttacgattga tcaatttatg gatgtagagc 47341 ttcgcgtagc tgaggtcatt gaggcagagc cagtgaaaaa agcagaccgt ttattgaagc 47401 tgcagcttga tcttggtttt gaaaagcgcc aagtggtatc cggcattgcg aagcattata 47461 cgcctgaaga gcttgttgga aaaaaactcg tttgtgtaac aaatctaaaa ccggttaaac 47521 tcagaggaga gctttctcaa ggtatgatcc ttgcaggaga agcagacggc gttttaaagg 47581 tcgtatctat cgatcagtcg ttaccaaaag gcacaagaat taaataatga taaacaaaag 47641 gtgtttcacg tgtaacaatt cgtcgaacac cttttgtgtt tcgacaagaa aggagttttt 47701 cacttatgtt gtttgacact cacgcgcatt taaatgcaga acaatatgat actgatcttg 47761 aagaggttat tgaacgggca aaagctgaaa aagttgaacg aattgtcgta gttggttttg 47821 accgtccgac gattacccgt gcgatggaaa tgattgagga atatgatttt atttatgcag 47881 ccattggctg gcaccctgtt gacgctattg acatgacaga ggaagactta gcgtggatta 47941 aagagctttc tgctcatgag aaagtggtag cgatagggga aatgggactg gattatcatt 48001 gggataaatc acctaaagat attcaaaaag aggtgtttag aaatcaaatc gccttagcga 48061 aagaggtcaa tttgcctatt atcattcata accgtgatgc aacggaggat gtcgtgacca 48121 ttttgaaaga ggaaggcgca gaagctgtgg gcggaatcat gcactgcttt acaggaagtg 48181 cggaagtggc aagagaatgc atgaaaatga atttttattt atcatttggg ggaccggtga 48241 catttaaaaa tgcgaagaaa ccgaaggaag tagtgaagga aattcccaat gaccggctgc 48301 tgattgaaac ggactgcccg tttctcacac cgcacccttt ccgcgggaaa agaaatgagc 48361 caagctatgt gaaatatgtg gcagaacaaa tcgccgaatt aaaagaaatg acctttgaag 48421 agattgcttc catcacgact gaaaatgcga aaagactttt ccgtataaac tgacaaaaaa 48481 cgctagcggg ttttgtaaga gcttgtccct tacagcgttt ttctataaaa gttctacatg 48541 ctttcttctc ctcataggat aggtttgtcg acaagtcttt cttccgtttc tcagtgtatt 48601 tcaggataat gaagaggaca ctgagctttt gggagaaaga gaagggaggg ttgacagcct 48661 tttagatact ctatataatc tctccgagga gaaggaggcg tttttcatca cacaaaaaat 48721 gaaaaagctg ttttccgtaa agcttagcaa aagcaaagtc attctggttg ctgcttgttt 48781 gcttttggca ggaagcggga ctgcgtacgc ggctcatgag ctgacgaaac aatcagtctc 48841 agtttctatc aatggcaaaa agaaacatat acgcacacat gcaaatacag tcggtgatct 48901 tttggagacg cttgatataa agacaagaga cgaagacaag atcacacctg ctaaacagac 48961 aaagataaca gcagacatgg acgttgtgta tgaggctgca aaacctgtga agcttacaat 49021 aaacggggaa gaaaagacgt tatggtcaac agcaaaaacg gtcggtgcat tactggacga 49081 acaagatgtt gatgtgaaag aacaagatca aattgatccc gcaatagata cagatatttc 49141 gaaagacatg aagattaaca tagagcccgc atttcaggtt actgtgaatg atgcagggaa 49201 acaaaagaag atctggacga cttcgactac ggtcgctgac tttttaaaac agcaaaagat 49261 gaacataaaa gacgaagata aaatcaagcc tgcgttagat gcaaagctga cgaaaggaaa 49321 ggctgatatt acaattactc gtatcgaaaa ggtcaccgat gtagttgaag agaagattgc 49381 gttcgatgtg aaaaagcaag aagacgcttc tcttgaaaaa gggaaagaaa aggtcgtcca 49441 aaaaggaaaa gaaggcaagc taaaaaaaca tttcgaagtc gttaaagaaa acggtaaaga 49501 agtgtccaga gagcttgtaa aagaagaaac agctgaacaa agcaaagata aagtgattgc 49561 tgtcggcaca aagcaaagca gtccaaaatt tgaaacggtc agtgcttcag gtgattcaaa 49621 aacagttgtg tcccgcagca atgaatcaac aggcaaagtc atgactgtat catctacggc 49681 ttatacggca agctgcagcg gttgttcagg acatacagcg acaggcgtca atttaaaaaa 49741 taatccgaat gccaaagtca tcgctgtgga tccaaatgtc attccgctag gctccaaagt 49801 ccacgtggaa ggctatggat atgccattgc tgcagatacc ggttcagcga ttaaagggaa 49861 caagatagac gtctttttcc cagagaaatc atcggcgtac cgatggggaa ataaaacagt 49921 caaaattaaa atcttaaatt agtatatact tatgtattca gagggttttg cgccctctgt 49981 ttttttcgtt ataatagaca aagtgcattt tctgcttatt agacgctcga tataagaaaa 50041 agtttcatga atatacaaaa gtttttattt tgtcttggag gaaataatga aaattaaaga 50101 gatcattgtg gtcgaggggc gtgacgatac ggcccgcatc aaattggctg ttgatgcaga 50161 cacaattgaa acaaatggtt cagccatcga tgatcatgtg attgaccaaa tccgtttggc 50221 ccagaagacg agaggcgtca ttattttaac ggatccggac tttccgggag agaagattcg 50281 caaaaccatc tcagaggctg tacccggctg taagcatgca tttttgccaa aacatcttgc 50341 caaacctaaa aacaagcggg gaattggtgt ggagcatgca tcggttgaaa gcattagggc 50401 atgtttagaa aatgtgcatg aggagatgga agcgcagccg agtgacattt cagctgagga 50461 tttgattcat gccggactaa taggcgggcc tgcggccaaa tgccgccggg aacgactggg 50521 tgatctgttg aaaatcggct atacaaatgg caaacagctt caaaaacggc tgcaaatgtt 50581 tcaaattaaa aaaagtgatt ttatgagtgc gctcgatacc gttatgcggg aggaacagaa 50641 tgaataaaga tattgcgaca ccgattagaa cgaaagagat actgaagaaa tacggttttt 50701 cttttaaaaa gagcttagga cagaatttct taattgatac gaacatttta aacagaattg 50761 ttgatcacgc ggaagtgacg gagaaaacag gtgtcattga aatcggcccg ggaatcgggg 50821 ctttaaccga acagcttgcc aagcgggcga aaaaggtcgt ggcatttgag attgaccagc 50881 gattattgcc gattctgaag gatacactgt caccttacga aaatgtcact gtcattcatc 50941 aggacgtgtt aaaggctgat gtcaaatcag tcattgaaga acaatttcaa gattgtgatg 51001 agatcatggt agttgccaac cttccttatt acgtaacaac accgattatc atgaaactgc 51061 ttgaagaaca tcttccgctg aaagggattg tggttatgct gcaaaaagaa gtggctgagc 51121 gcatggcggc tgatccttca tctaaggaat acggctcgct ttcaatcgcg gtgcagtttt 51181 atacagaagc caaaacggtg atgatcgtcc cgaaaaccgt atttgttcct cagcctaatg 51241 tcgattccgc agtcattcgt ctgattctcc gagacggccc ggcagtggac gtggaaaacg 51301 aatccttttt ctttcagctc atcaaggcaa gctttgcaca gcgccgtaaa acgctgctca 51361 ataacttagt taacaatctg cctgaaggaa aagcacaaaa atcaacgatt gaacaagtgc 51421 tcgaagaaac aaatattgac ggtaagcgcc gaggtgaatc cctgtctatt gaggaattcg 51481 cagcgctgtc taacggattg tataaagccc ttttctaaaa gggctttttg ttttgcgcac 51541 cacatggact gccgctacat aggctagaga aggacctttc attcaatgat aagaaaaaac 51601 ttggactcag cgaaaaaagg cgctttctca aggctctttc tttcatgatg aggcttagtc 51661 tatgtgtgga gtgaggaacg tgcaatttca aataggggat atggtagcca gaaaatccta 51721 tcagatggat gttttgtttc gaattatagg aatagagcaa acaagcaaag gaaattcaat 51781 tgccattttg catggagatg aagtcaggct gattgctgat tcggattttt ctgatctggt 51841 ggcagtgaaa aaggatgagc agatgatgcg gaaaaagaaa gatgagagca gaatgaatga 51901 gtcgctcgaa ttgctccgcc aagattataa gctgctcaga gaaaagcagg agtactatgc 51961 gacaagccaa tatcagcatc aggagcatta tttccatatg ccgggcaaag tgcttcatct 52021 ggatggtgac gaagcatatt tgaaaaaatg cctgaatgtc tataaaaaaa ttggagtgcc 52081 ggtctatggc atccattgcc atgaaaagaa aatgtctgct tctattgaag tattgctcga 52141 caaatatcga cctgacatcc tggtgatcac agggcatgat gcgtactcga agcaaaaggg 52201 cggtattgat gatttgaatg cgtacagaca ttctaagcac tttgttgaaa cagttcaaac 52261 agcccgaaaa aagatccctc acttagatca gcttgttatt tttgcggggg cctgccaatc 52321 ccattttgaa tcactcatca gagcgggtgc gaattttgca agttcaccgt caagagtcaa 52381 tattcatgcg cttgatccgg tatatatcgt cgcgaagatc agctttacgc cgtttatgga 52441 acggattaat gtatgggaag tgctccgtaa tacgctgaca agagagaaag ggcttggagg 52501 tattgaaaca agaggagttc tgagaattgg tatgccttat aagtccaatt aacagttgaa 52561 aacctgcata ggagagctat gcgggttttt tattttacat aatgatacat aatttaccga 52621 aacttgcgga acataattga ggaatcatag aattttgtca aaataatttt attgacaacg 52681 tcttattaac gttgatataa tttaaatttt atttgacaaa aatgggctcg tgttgtacaa 52741 taaatgtagt gaggtggatg caatggcgaa gacgttgtcc gatattaaaa gatcgcttga 52801 tgggaattta ggtaaaaggc tgacgttaaa agcaaacggt ggccgccgaa aaacgattga 52861 gcgttcgggc attttagctg agacgtaccc ttctgttttt gtgatacaac tagatcaaga 52921 cgagaactcg tttgaaagag tttcatacag ttatgctgat attttgactg agactgttga 52981 gctgacattt aatgatgacg ccgcaagctc agtggcattt taacgggcag tgaacctttt 53041 gtttactgct ttttgttttg cccttttttg gtttccaata attttaacga aagttccatc 53101 tgatttaaca aaagataaaa cagtcacata ttatcgtgac gtgcacgaat ggctatcact 53161 tctaaaaaag gagttgtttc gtttgggcag acgtcgtgga gttatgtcag atgagtttaa 53221 atatgagctg gctaaagacc ttggttttta tgacacagta aaaaatggag gctggggtga 53281 aattcgggcc cgcgatgccg gtaacatggt gaagcgtgct attgaaatcg ccgaacagca 53341 aatggctcag aatcagaata accgataagg atgtgacccg ggggacgtgc tgttccctgg 53401 tttttttatt ttggatataa atacataatg ggctgaatat ggatatgttc atcctgtact 53461 tcaaatgtga tacaatgttc atacttatgt ttagatggag aagtaggtga aagctatgcg 53521 tattttagaa aaagcgccag ctaagatcaa tctgtcactt gacgtcaccc gaaaacgccc 53581 ggatggctat catgaagtcg aaatgatcat gacgacaatt gatttagctg atcgaattga 53641 attgacggag cttgcagagg atgaagtgag ggtttcctcc cacaaccgat ttgtgcctga 53701 tgaccaaaga aacttagctt atcaggctgc caagctgatc aaggacagat acaacgtgaa 53761 aaagggagtt tccatcatga ttacgaaggt aattccggtg gctgccggtc ttgccggcgg 53821 aagcagtgat gcggcggcga cactcagagg gctgaacaga ctgtggaatt taaatctgtc 53881 cgcggaaacg cttgctgagc ttggagcgga aattggctct gacgtttcat tttgtgtcta 53941 tggcggaact gcattagcaa cagggcgcgg cgagaaaatt aaacatatca gcacgcctcc 54001 gcactgctgg gtcattttag cgaagccgac aatcggtgtt tcaactgctg aagtgtacag 54061 agcgctgaaa ctggatggta tagagcatcc cgatgtacaa ggcatgatcg aggcgataga 54121 agaaaagagt tttcagaaga tgtgcagccg gttaggcaat gtgcttgaat ctgttacact 54181 cgatatgcat cctgaagttg cgatgatcaa aaaccagatg aaacgctttg gtgcagatgc 54241 cgtgttaatg agcgggagcg gcccgacagt gtttggactg gttcagtatg agtcgaaggt 54301 gcagagaatt tataacgggt taagaggctt ctgcgatcaa gtttatgcgg tgagaatgat 54361 cggcgaacag aacgctcttg attaaatccg tatgttaagt tatattgatc ttaaaatatt 54421 cggattttgg gggtgagttc atgaagtttc gtcgcagcgg cagattggtg gacttaacaa 54481 attatttgtt aacccatccg cacgagttaa taccgctaac ctttttctct gagcggtatg 54541 aatctgcaaa atcatcgatc agtgaagatt taacaattat taaacaaacc tttgaacagc 54601 aggggattgg tactttgctt actgttcccg gagctgccgg aggcgttaaa tatattccga 54661 aaatgaagca ggctgaagct gaagagtttg tgcagacact tggacagtcg ctggcaaatc 54721 ctgagcgtat ccttccgggc ggttatgtat atttaacgga tatcttagga aagccatctg 54781 tactctccaa ggtagggaag ctgtttgctt ccgtgtttgc agagcgcgaa attgatgttg 54841 tcatgaccgt tgccacgaaa ggcatccctc ttgcgtacgc agctgcaagc tatttgaatg 54901 tgcctgttgt gatcgttcgt aaagacaata aggtaacaga gggctccaca gtcagcatta 54961 attacgtttc aggctcctca aaccgcattc aaacaatgtc acttgcgaaa agaagcatga 55021 aaacgggttc aaacgtactc attattgatg actttatgaa agcaggcggc accattaatg 55081 gtatgattaa cctgttggat gagtttaacg caaatgtggc gggaatcggc gtcttagttg 55141 aagccgaagg agtagatgaa cgtcttgttg acgaatatat gtcacttctt actctttcaa 55201 ccatcaacat gaaagagaag tccattgaaa ttcagaatgg caattttctg cgttttttta 55261 aagacaatct tttaaagaat ggagagacag aatcatgaca aaagcagtcc acacaaaaca 55321 tgccccagcg gcaatcgggc cttattcaca agggattatc gtcaacaata tgttttacag 55381 ctcaggccaa atccctttga ctccttcagg cgaaatggtg aatggcgata ttaaggagca 55441 gactcatcaa gtattcagca atttaaaggc ggttctggaa gaagcgggtg cttcttttga 55501 aacagttgta aaagcaactg tatttatcgc ggatatggaa cagtttgcgg aagtaaacga 55561 agtgtacgga caatattttg acactcacaa accggcgaga tcttgtgttg aagtcgcgag 55621 actcccgaag gatgcgttag tcgagatcga agttattgca ctggtgaaat aataagaaaa 55681 gtgattctgg gagagccggg atcacttttt tatttacctt atgcccgaaa tgaaagcttt 55741 atgacctaat tgtgtaacta tatcctattt tttcaaaaaa tattttaaaa acgagcagga 55801 tttcagaaaa aatcgtggaa ttgatacact aatgctttta tatagggaaa aggtggtgaa 55861 ctactgtgga agttactgac gtaagattac gccgcgtgaa taccgatggt cgcatgagag 55921 cgattgcatc catcacgctg gatcacgaat ttgttgtaca tgatattcgt gtgattgatg 55981 gaaacaatgg tcttttcgtt gcgatgccga gtaaacgcac ccctgatgga gagttccgcg 56041 atattactca tcctattaat tcaagcacgc gaggaaagat tcaagatgcc gtgttaaatg 56101 agtatcatcg tctgggtgac actgaagcat tagaattcga agaagctgga gcttcttaaa 56161 aaataaccaa aaagcaagga ctgctgaaag ggctgacata agccttttgc cggcggtcct 56221 tttttaattc tgatttttca aacttagttg cactcaatag aaaattcttg cacttcatga 56281 agtctccttg aaatcagaag atatttagga tatatttttc tatggataaa agggatattg 56341 gaggccaata aatggataag cggtttgcag ttgttttagc ggctggacaa ggaacgagaa 56401 tgaaatcgaa gctttataaa gtccttcatc cagtttgcgg taagcctatg gtagagcacg 56461 tcgtggacga agccttaaaa ttatctttat caaagcttgt cacgattgtc ggacatggtg 56521 cggaagaagt gaaaaagcag cttggtgata aaagcgagta cgcgcttcaa gcaaaacagc 56581 ttggcactgc tcatgctgta aaacaggcac agccatttct tgctgacgaa aaaggcgtca 56641 caattgtcat ttgcggagat acgccgcttt tgacagcaga gacgatggaa cagatgctga 56701 aagaacatac acaaagagaa gcgaaagcta cgattttaac tgcggttgca gaagatccaa 56761 ctggatacgg ccgcattatt cgcagcgaaa acggagcggt tcaaaaaata gttgagcata 56821 aggacgcctc tgaagaagaa cgtcttgtaa ctgagatcaa caccggtacg tattgttttg 56881 acaatgaagc gctatttcgg gctattgatc aggtgtctaa tgataatgca caaggcgagt 56941 attatttgcc ggatgtcata gagattctta aaaatgaagg cgaaactgtt gccgcttacc 57001 agactggtaa tttccaagaa acgctcggag ttaatgatag agttgctctt tctcaggcag 57061 aacaatttat gaaagagcgc attaataaac ggcatatgca aaatggcgtg acgttgattg 57121 acccgatgaa tacgtatatt tctcctgacg ctgttatcgg aagcgatact gtgatttacc 57181 ctggaactgt gattaaaggt gaggtgcaaa tcggagaaga tacgattatt ggccctcata 57241 cggagattat gaatagtgcc attggcagcc gtacggttat taaacaatcg gtagtcaatc 57301 acagtaaagt ggggaatgat gtaaacatag gaccttttgc tcacatcaga cctgattctg 57361 tcatcgggaa tgaagtgaag atcgggaatt ttgtagaaat taaaaagact caattcggag 57421 accgaagcaa ggcatctcat ctaagctatg tcggcgatgc tgaggtaggc actgatgtaa 57481 acctgggctg cggttcaatt actgtcaatt atgatggaaa gaataagtat ttgacaaaaa 57541 ttgaagatgg cgcgtttatc ggctgcaatt ccaacttggt tgcccctgtc acagtcggag 57601 aaggcgctta tgtggcggca ggttcaactg ttacggaaga tgtacctgga aaagcacttg 57661 ctattgccag agcgagacaa gtaaataaag acgattatgt gaaaaatatt cataaaaaat 57721 aatcctaaat tcggaggttt atccatgtct aatcaatacg gagataagaa tttaaagatt 57781 ttttctttga attcgaatcc agagcttgca aaagaaatcg cagatatagt tggagttcaa 57841 ttagggaaat gttctgtcac aagatttagt gacggggaag tccaaattaa tatcgaagaa 57901 agtattcgcg gatgtgattg ttacatcatc cagtctacaa gtgaccccgt taacgagcat 57961 attatggaac tgctgattat ggtagatgcg ttaaaacgcg cttctgcaaa aacgattaac 58021 attgttattc cttattacgg ttatgcgcgt caagacagaa aagcaagatc ccgtgagcca 58081 atcacagcta aacttttcgc taacctgctt gaaacagccg gtgcgactcg tgtgattgca 58141 cttgacctgc atgcgccgca aattcaagga ttctttgata taccgattga ccacttaatg 58201 ggtgttccga ttttaggaga atattttgaa ggcaaaaatc ttgaagatat cgtcattgtt 58261 tcaccagacc atggcggtgt gacacgtgcc cgcaaactgg ctgaccgact aaaagcgcca 58321 attgcgatta tcgataaacg ccgtccgcgt ccaaacgtgg cggaagtcat gaatattgta 58381 ggtaacatcg aagggaagac tgctatcctc atcgatgaca ttattgatac tgcaggtacg 58441 attacacttg ctgctaatgc gctcgttgaa aacggagcga aagaagtata tgcatgctgt 58501 acacaccctg tactatcagg ccctgcggtt gaacggatta ataattcaac aattaaagag 58561 cttgttgtga caaacagcat caagcttcct gaagaaaaga aaattgaacg ctttaagcag 58621 ctttcagtcg gaccgcttct ggccgaagcg attattcgcg ttcatgagca gcaatcagtc 58681 agctatctgt tcagctaaac catttttcga ggtttaaatc cttatcgtta tgggtattgt 58741 ttgtaatagg acaactaaaa cgacaagagg atggtgctga atatggcaac tttaacggca 58801 aaagaaagaa cggactttac tcgttcgtct cttcggaata tccgtacttc aggacatgtt 58861 ccaggtatca tatatgggaa ggatacgggt aacaaacctg tgtcattaga cagtgtggag 58921 ctcatcaaaa cgctgaggga cgaaggcaaa aatgcagtca ttacgcttga ggtcagcgga 58981 gaaaaacact cagtcatggt aacagacctg cagacggacc cgctgaaaaa tgaaatcact 59041 catgctgatt ttcaagtagt taatatgagt gaggacattg aagtggaagt tccgattcat 59101 ctgaccggag aagccattgg agtgaaaaac ggaggcgtac tgcagcagcc gttatatgca 59161 cttactgtaa aggccaagcc aaaagccatt ccgcaaacga ttgaggctga tatttcaagc 59221 ctcgatgtaa atgaagtact gacgattgcg gatttgcctg ctggcggtga ctactccttt 59281 aatcatgaat cagatgaggt tgtggcttca atccttcctc cgcagcagca ggaagcagct 59341 gaggtcgatg aagaggaatc tgccgatgct cagcctgaag gtgaaaacga acaataatag 59401 cttaaggcgt aaccctcccg cggttacgtc ttttgtgcta gaatgagaag aattatagcc 59461 cgtttatgaa gacgggagtt atgtgactaa gggaggattc gccatgcttg tgattgccgg 59521 tctcggaaac ccggggaaga actatgaaaa tacacggcat aatgtcggat ttatggtgat 59581 agatcagctt gcaaaggaat ggaatataga gctgaatcaa aataaattta acggattata 59641 cggaaccgga tttgtttccg gcaaaaaggt tctacttgtt aaaccgctta catatatgaa 59701 tttatcagga gaatgtttgc ggcctttaat ggactactat gatgtcgata acgaagattt 59761 gacagtcatt tacgacgacc ttgaccttcc gactggcaag atccgtttaa gaacgaaagg 59821 aagcgccgga gggcacaatg gcatcaaatc actgatccag catcttggaa cgtccgagtt 59881 tgaccgtatc cgcatcggaa tcggccggcc tgtaaacggc atgaaggtcg ttgattatgt 59941 gttaggctcc tttaccaagg aggaggcacc tgagatcgaa gaagcggttg ataaatctgt 60001 gaaggcttgt gaggcttctt tgagtaaacc gtttttagaa gtcatgaacg aatttaacgc 60061 aaaggtataa aatgtaacaa caaagtccat actacaccaa aatgactttt tcatcaggag 60121 gacccttgta tggctttgca ttattattgt cgtcattgcg gagtgaaagt aggcagtctc 60181 gaatcttcaa tggtatcgac agactcactt ggatttcagc acttaacaaa tgaggaaaga 60241 aacgatatga tttcttataa agaaaatgga gatgtccatg ttttgacgat atgtgaagac 60301 tgccaagagg cgcttgaccg aaatccgcat taccacgaat atcacacatt tattcaataa 60361 aaagctttgg tgtagacact agaccaaagc gtttttctgt tctcgcagga aacagagagg 60421 aggggccata tggacaacat tcaaaccttt ataaaagaaa gcgatgactt taaatccatc 60481 atcaacggtt tacacgaggg cctgaaggaa cagctgctcg cgggtctgtc gggttccgcg 60541 cgttctgttt ttacttctgc tctggctaat gaaacgaata agcctatctt tctcatcacc 60601 cataacttat atcaagccca gaaagtaaca gatgatctga cttcacttct agaggatcgg 60661 tctgtccttt tgtaccccgt caatgaactc atttcatcag aaatcgcagt tgcaagccct 60721 gaattgcggg cgcagcgatt agatgtcatt aatagactaa cgaatggaga agcgccaatt 60781 gtcgttgctc cggtagctgc aatcagaaga atgctgccgc ctgttgaggt gtggaaaagc 60841 agccagatgc tcattcaagt aggccatgat attgaacctg accagcttgc ctcacggctg 60901 gtagaggtag ggtatgagcg gtctgatatg gtttctgcgc ccggggaatt cagtattcgc 60961 gggggaatca ttgacattta tccgctgact tcagagaatc cggtgagaat tgaacttttt 61021 gacaccgagg tggattcaat ccgcagcttt aattcagatg atcagcggtc aattgagacc 61081 cttacctcga tcaatatcgg tcccgcgaag gaattaatta tcagaccgga agaaaaagcg 61141 cgggcgatgg agaaaatcga tagtggtctt gccgcgagct tgaaaaaatt aaaggctgac 61201 aaacaaaaag aaatacttca tgcgaatatt tctcacgata aagaacgctt gtctgaaggc 61261 cagacagatc aggagctcgt gaagtatctc tcatatttct atgaaaagcc tgctagttta 61321 ctagattata cacctgataa tacacttctg attttggatg aagtcagtcg gattcatgag 61381 atggaagaac agcttcaaaa agaagaagcg gagtttataa caaatcttct tgaggaaggg 61441 aagattttgc atgacattcg tttgtcattc agcttccaaa aaatagtggc tgagcaaaaa 61501 cggcctctgc tgtactactc tttatttttg cggcatgtac accatacgag cccgcaaaat 61561 atcgtcaatg tgtcaggccg gcaaatgcag agtttccatg gccaaatgaa cgtgcttgcg 61621 ggcgaaatgg agcgttttaa aaaatcaaat ttcactgttg tgttcttagg agcaaacaag 61681 gaacgtacgc agaaattgtc atctgttttg gctgattatg atatcgaggc cgccatgaca 61741 gacagcaaaa aagcgcttgt tcagggacag gtctatatca tggaaggcga gctccaatcg 61801 ggatttgagc tgccgttaat gaagcttgcc gttatcacgg aagaagaact gttcaaaaac 61861 cgtgtaaaga agaagccgcg aaaacagaag cttaccaatg cagagcgcat caaaagctat 61921 tctgagcttc aaattggaga ttatgtcgtt catattaatc acgggatcgg aaaatacctg 61981 gggattgaaa ctcttgaaat caacggcatt cataaagact atttaaatat acattatcag 62041 ggcagtgaca agctttacgt ccctgtagaa caaattgatc aggtccaaaa atatgttggc 62101 tccgaaggaa aagagccaaa gctgtataaa ttaggcggaa gtgaatggaa gcgggtcaag 62161 aaaaaagtag agacatccgt tcaggatatt gctgatgact taattaagct gtatgccgaa 62221 agagaagcga gcaagggcta tgcgttttct cctgaccatg agatgcagcg tgaattcgaa 62281 tcggctttcc cttatcaaga gactgaggat cagctccgtt ctattcacga aatcaaaaaa 62341 gacatggaaa gagaacgtcc gatggaccgc ttgctgtgcg gagatgtggg ctacggtaaa 62401 acagaggttg ccatacgtgc cgcgtttaag gcgatcggtg acggaaagca ggtagctctg 62461 ctcgttccga caaccatttt ggcacagcag cactatgaaa ccataaaaga gcgcttccag 62521 gactatccga ttaatatcgg ccttctcagc aggttcagaa cgagaaaaga agcaaacgaa 62581 acaatcaaag ggctgaaaaa tggaacggtt gatatcgtca tcgggacgca tcggctgcta 62641 tcaaaggatg tcgtgtataa agacttaggg ctcctcatca ttgatgaaga gcagcgtttc 62701 ggtgtaaccc ataaagaaaa gatcaagcaa ataaaagcca atgttgatgt attaacgtta 62761 acagcaacgc cgattccgcg tacgctgcat atgtctatgc ttggcgtaag ggacctttca 62821 gtcatcgaga ctccgccgga aaatcgcttc cccgtacaga cgtatgttgt ggaatataac 62881 ggcgctcttg tcagagaggc gattgaacgt gagcttgcac gcggaggcca ggtctatttc 62941 ttgtacaacc gggtagagga cattgagcgg aaagcggatg aaatttcaat gctagtccct 63001 gacgcgaagg tagcatatgc gcatgggaaa atgacagaaa atgaattaga aaccgttatg 63061 ctaagcttcc ttgaaggaga atcagacgtt ctcgtcagca caaccattat cgaaactggc 63121 gtggacatcc caaacgtcaa tacgctgatc gtatttgacg ccgacaagat gggactttct 63181 cagctttacc agctgcgggg gcgtgtcggc cgttctaacc gtgtggcgta tgcgtacttc 63241 acgtatcgcc gggataaagt gctgacagaa gtggctgaaa aaaggctgca ggctattaaa 63301 gaattcacag agttaggttc cggttttaaa atcgcaatgc gtgacttaac gattcgcgga 63361 gccgggaatc ttcttggtgc ccagcagcat ggcttcatcg attcggtcgg atttgacctc 63421 tattcacaaa tgctgaagga ggccattgag gagcgtaaag gagacacagc gaagacagag 63481 cagtttgaaa cagaaattga tgtcgagctt gatgcgtata ttccggaaac ttatattcaa 63541 gacggcaaac agaaaattga tatgtataaa cgcttcaggt ctgtggcgac aatcgaagag 63601 aagaatgagc ttcaagatga aatgatcgac cgctttggaa actatccaaa agaagtcgaa 63661 tacttgttta ctgttgcaga aatgaaagtc tatgcgagac aggaacgtgt cgagctgatt 63721 aagcaggata aagatgctgt cagattgacg atttctgaag aagcaagtgc tgaaattgac 63781 gggcagaagc tgtttgagct tggcaatcaa tatggcagac aaatcggact gggaatggaa 63841 gggaaaaaac tcaaaatctc catacagacg aaaggccgta gtgctgatga atggctcgac 63901 accgtgctgg gcatgctgaa gggcttaaaa gatgtgaaaa agcaaaccat ttcatcaacg 63961 taaattttgt tactctctgg tgtatattac atttgatgtg acggatacta atttcaagcg 64021 aggcggaagg tacataaagt aactgcttta ggtctttccc acatgtatat accatcaaat 64081 gaaagagagg caccagagat gaaagcaacc ggtatcgtac gtcgtattga tgacttaggt 64141 cgggtcgtga ttcctaaaga aattcgaaga actctgagaa tcagggaagg cgatccgctt 64201 gagatttttg tagatcgtga cggagaagtg attttgaaaa agtactctcc gatcagtgag 64261 cttggagact ttgcaaagga gtatgcagac gcgctttacg acagcctcgg ccattcagtg 64321 ctgatttgtg atcgtgatgt atatattgcc gtgtccggca gctccaaaaa agattactta 64381 aacaagtcaa tcagcgaaat gctggaaaga acaatggatc agcgcagctc cgtgcttgag 64441 agtgatgcga aatcagtaca gcttgtgaat ggaattgatg aggacatgaa ttcttatact 64501 gtaggcccaa ttgtggcgaa cggtgatccg ataggtgctg tggtgatctt ttcaaaagat 64561 cagacaatgg gcgaagtaga gcataaagcc gttgaaacag cagctggatt tttggctcgt 64621 caaatggaac agtaggtctt attcctttct tcgaaaatag gtatgtaaag aacagctctc 64681 cttgggacgc tgttcttttt catgcgtgcc gaaaaaggaa tccaagggtt gggatgtggt 64741 ataataacct cgtttttatt tgtgccgcgg taatacgtga accgtattgc ccctgacgtt 64801 gggaaggagc ttttggatgg acgattcaat aggcgttaaa cggcattgga tttggcaggg 64861 ggcttttgtt ttaattctgg caggcgtcat cacaaaaatt ttaagcgctg tttacagagt 64921 cccgtttcaa aacattgtcg gcgatgttgg attttatata tatcagcagg tatacccctt 64981 tcttggtatt gcggtcatgc tgtccacatc aggatttcca gtcattattt caaagctgat 65041 gaatgattat agtgaaaaaa atcatcacac catattaaaa atatcagcgt tgtttttgtc 65101 tttaatcggt attttattat ttctttgttt atatctgggt gctgttccta ttgcactctt 65161 tatgggagat tcgcatctag ccgtgttaat tcaagtggcc gcatacgcgt ttctgctttt 65221 cccatttgtc gcgttgctaa gaggcggttt tcaggggcgg cacgaaatgc tcccttcagc 65281 cttatcacag atgacagagc agtttctgcg tgttgcggtg ctcttgggtt tatcattttg 65341 gctcgtgaaa aagggagcct cgctttatac tgcgggagcg gcagccgctt caggctctct 65401 tgccggaagt ttggttgcat tgataatact ggggtttttt tggttcaaaa cgaaaagaga 65461 caaccaaacg gataggcaaa acgaaaatgt catcacaaca aaagaattga cgaaaaaact 65521 gcttttatat tcggtcacaa tttgtgtaag cagtttgctg cttttgttta tccagcttgt 65581 tgatgctttg aatttatatg cattgctttc gggtggtgag gcaagcgaag aagcaaaatg 65641 cctaaagggg atctatgatc ggggacaacc cttgttgcag ctcggttcag tttttgccgt 65701 aagcattgcg acgtcactcg ttccgtatat ttctatggct gtaaaaaaca aagagctgaa 65761 gatcatgaaa gaaaaaatca cgtcatcttt gaaactatgc cttgtgctcg gtacaggcgc 65821 atcggctggg ttgatttgca ttctaaagcc ggtaaatatc atgctgtttc aaaatggaga 65881 agggacaggt gcgttacaag tatttagctg ctccattttg tttgcatcct tggcggtaac 65941 ggcagcggca gtcttacagg gagcgggata cacagttttt cctgcgatag cggtgggcgc 66001 gggtgttgcg gtgaaatggg tgttaaacac acttttggtt ccgcgctatg ggattgaagg 66061 cgcatcgctt gcgacagcgg cttcctttgc ggctgtcgcc ggccttaact tgtatcagct 66121 tcggcaaaag gaatggctcg ataagcttag aggcgttttg attccgatta ttggatctgc 66181 tcttttgatg tcagctgttt tgcttgcgta tacgcgtctc tggactttct tgtttcctgc 66241 aacaggaaga ggagcggctg tgattgagag tctttctgct gttgccattg gtggcgcggt 66301 gtttatttat tgtatgatga gattgggaat atttacagat gaagagctga acagtgtgcc 66361 attcggcagc aagttaagca aattcatgag aaggagagaa caaaatggcg ggtaaaatta 66421 cagtcgtcgg acttggtgcc ggagacatgg accaattgac aattggtata cacaagctgc 66481 tgacgaaggc agatacgctg tatgtcagaa ccaaggatca tcctttaatt gaggagcttg 66541 aaaaagaaac gaagaacatc cgtttctttg atgatatata tgagaaacat gatcagttcg 66601 aggcggtata tgaagaaatt gcagatatcc tctttgaagc ggcgcggcgt gaggacgtgg 66661 tttacgctgt gccgggacac ccttttgtcg cagaaaaaac agttcagctg ctgacggagc 66721 ggcaggaaaa ggaaaacgtt caagtgaaag tcgcgggggg acaaagtttc cttgatgcca 66781 cattcaatgt cttgcaaatt gacccgattg aaggttttca atttgtggat gccggcacat 66841 tgtccgcgga tgagcttgag ctcagacatc atctgatcat atgtcaggtt tacgaccaaa 66901 tgacggcttc tgaagtcaag ctgacattga tggagaagct gcctgatgat tatgaggtcg 66961 tcattgtgac tgcagcaggc agccgtggcg aggagatcag gacagtgcca ttatttgagc 67021 tggaccgcaa tgtcgctttg aacaacttaa caagtgtgta tattccgccg attaaagaag 67081 agaagctgct ttatcacgaa ttctccacgt tccgaagcat catcagagag cttcgcggac 67141 ctaatggatg tccgtgggat aaaaagcaga cgcatcagtc attaaagcag tacatgattg 67201 aagaatgtta tgagcttctc gaagctattg acgaagaaga cacagaccat atgatcgaag 67261 agcttggcga cgttttgctt caggtcttgc ttcacgcgca aattggtgaa gatgaaggtt 67321 atttcacaat tgatgatgtc ataaaaggaa tcagtgaaaa aatggtccga agacatcccc 67381 atgtgtttaa agatgttaag gttcaggatg aaaacgatgt tttagccaat tgggaagata 67441 taaaaaaggc cgaaaaaaat acatctgaat catcattact agacagcgta ccgaaaaccc 67501 ttccagctct ttcgaaagca gctaaattgc agaaaaaagc agcgaaggtc ggttttgact 67561 gggaagacgt cagcgatatt tgggaaaagg taagtgagga aatgaaggaa ttttcttctg 67621 aggtttctga agctcctcac gaacacaatc ttaaagctga gtttggcgac attttgttcg 67681 cgctggtgaa tgtagcccgc ttctacaaaa tagagccaga ggaagcgctg accatgacta 67741 atgacaaatt ccggagacgg ttctcgtaca ttgaggaaac agcgaaggaa gagggagtcg 67801 agttggctga tatgtccctt gaggacatgg acaaactgtg gaatgaagca aaagaaactg 67861 agaggagatc atagatatga gattagataa atttttgaaa gtatcacggc tgatcaaacg 67921 gcgtacacta gcgaaggaag tagctgacca aggacgaatc tctattaacg gaaaccaagc 67981 taaagctagc tctgacgtaa aaccgggaga tgaactaacg gtccgcttcg gccaaaagct 68041 tgtaacggtt caagttaatg aattgaaaga cacgacgaaa aaagaagaag ctgcaaacat 68101 gtacacgatt ctaaaagaag aaaaactcgg cgaataggct tgttctaaaa aaacccccca 68161 cctcatacaa tgcagtaata atgctaaaag tatcgaggat atgggggctg aatagatgaa 68221 ttcatattat gatcaaaaag gttcttcgtc tgttccggaa cagcatgatg tgacaatgaa 68281 aggccggaag catttagata tttctggggt taagcatgtg gagagttttg ataacgaaga 68341 attcctgctg gaaacggtga tgggaatgct ctccgtcaga ggccaaaacc tgcagatgaa 68401 aaatcttgat gtggaaaaag ggattgtttc gattaaaggc agggtatttg atttagtgta 68461 cttagacgaa caacaagggg ataaagctaa agggtttttt agcaagttgt ttaaatgacg 68521 ctgacgacac aattctatac aatgctagcg atgtccggta tgggtctctg gcttggtgct 68581 tcgcttgata cataccggct ctttgtcatt cgtgccaaaa cagccagatg gctattattt 68641 attcatgata ttcttttctg gattatgcaa gggctgcttt tcttttatgt cttgcttcat 68701 gtaaatgagg gagaattcag gatttacatc tttttagcgg ttctgctggg cgttgcgacg 68761 tatcagagcc tttgcaaacg aatctatata aaaatactga aattcgtcat ttaccttgtt 68821 gtttctgttt atcaattctt caaaaaactc attcagcacg tgttatttcg tcctattgtg 68881 tggacatgcg gagcgatcat ctggctggcg gcatttttat tcaagaaaac atacagcctg 68941 ataggttttc tcctgctgtg tctatataaa atagtcatgg ttctgtgttt tccgatccgt 69001 tttatcgcga aacaatgttt gaaacttctt cctgtgaaaa tgcgtctaac ttttagacgt 69061 tattttgaaa aaggtgcagg atttctcaaa aagaagaaga aactattgat aaccataaga 69121 acgaccatca cacggttttt gaagagatga aaggaggacc gtctggtttg aatttttcca 69181 gggaacgaac gataactgaa atacaaaacg actataaaga acaagtagaa cggcaaaatc 69241 agctgaagaa acgaagacgc aaagggctgt acagacggtt aactgtattc ggcgccctag 69301 tattcctgac ggcaattgtg ctggcaagct ctgtatggtc ccaaacatct tcccttagtg 69361 caaaagaaga aaagaaagaa cagcttgaaa aagaactgaa aagtttaaag acaaaacaaa 69421 cggatttaaa agaagaaata tccaaattga aggatgagga ttacgtcaca gagcttgcca 69481 gaagggactt attcatgtct ggagacggag aaattatctt caatgtggag aagaagagca 69541 agtagccttg ttgacactta aatttttatt taggtataat taagcaaacg atctttttat 69601 aagcctaagg aggagcactt tttttatgtc gattgaagtt ggcagcaagt tgcaagggaa 69661 aattacaggt attacaaatt ttggagcatt tgttgaattg cctggaggct caaccggtct 69721 cgttcacatt agtgaggtag ctgataatta tgtcaaagac attaacgacc acttaaaagt 69781 cggcgaccaa gttgaagtga aagtcatcaa cgttgaaaaa gacgggaaaa ttggtttatc 69841 tattaaaaaa gctaaagacc gtccgcaagc cagacctaga aatgatttcc gtccgaaaga 69901 atcttttgaa cagaaaatga ataagttttt aaaagacagc gaagatcgct tgtcatcttt 69961 aaaacgcaat acggaatcaa aacgtggagg gcgcggagca agaagaggat aacttgctgc 70021 tttctataaa ataaatgaag catccgttca tcccgacgga tgctttttta ttatcctcat 70081 tctctttaag agtcagaaaa ttacaacatt aaagtttctg ttgacgaaag agacaaacct 70141 ttgtattata taacttgtgc ttagaagcac aaaacaatat ggcggtgtag ctcagctggc 70201 tagagcgtac ggttcatacc cgtgaggtcg ggggttcgat cccctccgcc gctaccatat 70261 ttgtttggcc cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt 70321 cgaatcccgt acgggtcatc ctaacaaatc ggtttctctt gcagaagccg atttttttca 70381 tttttagaca acattccgga aattcttttc ataaacgaat atcaaggcag aaaccgtcga 70441 agatttcttt ggtattgtta ccttcttttg acaaaatcct atctgtgctt tcgctataat 70501 gacaggcaac gaatataaca ggtgggagat gagaggaatg gaaaaagcag aaagaagagt 70561 gaacgggcca atggcgggac aagctttgga aaaactccaa tcgtttttta acaggggcac 70621 gaagctggtg actcatcatt tgcattcact gtttttctat aaaggattca tttatgttgt 70681 catcggattt ttgcttggac gggctttcat attatccgag gtgcttcctt tcgcacttcc 70741 tttctttgga gcgatgcttc ttatcagaag agacaaagcg ttttatgcgg ttttggctgt 70801 gcttgcaggt gcgctgacca tatctccaaa gcactcattg ctcatactgg cggcattgct 70861 ggcattcttc gtattttcta aagtggctgc cttcattacc gacgatcgtg ttaaagcgct 70921 cccgattgtc gtgttcttct ccatggctgc agcaagagcc gggtttgttt atgcccaaaa 70981 tggcgtattt acaacctatg attatgtaat ggctatcgtt gaggctggac tatcgtttat 71041 cttaacactg attttccttc agagccttcc gatttttact gtgaaaaaag tgaaacaatc 71101 attaaaaata gaggaaatca tttgctttat gattcttatt gcctctgttt taacggggct 71161 ggctggcttg tcctaccaag ggatgcaggc agaacatata ttggctcgtt atgttgtgtt 71221 gagtttttcc tttattggcg gagcaagcat cggctgtacg gttggggttg tgaccggcct 71281 gattcttggc ttggcgaata tcggaaacct atatcaaatg agtctgcttg ctttttccgg 71341 tttattgggc ggtttgctga aggaagggaa aaaagcgggt gcagcaattg gtttgatcgt 71401 tggatcactt cttatatctt tatatggtga aggctctgcc ggtctgatga caacgctcta 71461 tgagtcatta atcgcagtct gcctgttttt gctcacacct caatctatta cgaggaaagt 71521 ggcgagatat attccgggaa ctgtcgagca tcttcaagag caacagcaat acgctagaaa 71581 aatccgtgat gtcactgctc agaaggtaga ccaattctcc aatgtatttc acgcgctgtc 71641 tgaaagcttt gcaacctttt atcaagcatc agacgaacag acagatgaca gcgaagttga 71701 tctgttctta agcaaaatca cggagcattc ctgccagacg tgctacaaga aaaacaggtg 71761 ctgggtacag aactttgata aaacatatga cttaatgaaa caagttatgc ttgaaacaga 71821 ggaaaaagaa tatgcatcaa accgaaggct gaaaaaagag tttcaacagt attgttctaa 71881 atccaagcag gttgaagagc tgattgagga tgagctcgca catcatcatg cccatttgac 71941 actcaagaaa aaagtccaag acagcaggcg ccttgttgct gaacagcttt taggcgtttc 72001 tgaggttatg gccgactttt ctcgggaaat aaaaagagag cgagaacaac actttctgca 72061 ggaagagcaa atcatagaag cgcttcagca tttcggaatt gagattcagc atgtcgagat 72121 ctatagtctt gaacaaggaa atatcgatat tgaaatgacc attccgttca gcggacatgg 72181 agaaagtgaa aaaatcattg ctcctatgct ttctgacatt ctggaggaac aaattcttgt 72241 gaaagccgaa cagcactctc cgcatccgaa tggatacagc catgtcgcct ttggatcaac 72301 aaaatcatac agggtgtcca cgggagctgc tcacgctgcg aagggcggcg gccttgtctc 72361 cggtgacagc tacagcatga tggagcttgg agccagaaaa tatgctgcag caatcagtga 72421 cggaatgggc aatggcgcaa gagcgcactt tgaaagcaat gaaacgatca agcttcttga 72481 aaaaatcctt gaatcgggca ttgatgaaaa aatagcaatt aaaacgatca acagcatact 72541 gtctctaagg acaactgacg aaatatattc cacgcttgac ctatctatta tcgatcttca 72601 agatgccagc tgtaaatttt tgaaggttgg atcgacgccc agctttatca aacggggtga 72661 ccaggtcatg aaagttcaag cgagcaatct gccaatcggt attattaatg aattcgatgt 72721 ggaggttgtg agtgaacagc tgaaagcggg tgacctctta attatgatga gtgatggcat 72781 ttttgagggg cctaagcatg tggaaaatca cgacttatgg atgaagcgta aaatgaaagg 72841 gttgaaaaca aatgacccgc aggagattgc cgatttgctt atggaagaag tcatccgcac 72901 aagatccggc caaattgagg acgatatgac tgttgttgtc gtccggattg atcacaatac 72961 accgaagtgg gcatccattc ctgttccggc aatctttcaa aacaaacaag aaatttcata 73021 acgcttccgt ataaatcaaa tttcttctgg cgaagatggg aatatatgaa tctgagaatc 73081 ctcgtattct ccaggaggaa tgaatgtgaa caacggacat ttaaatcaaa ttttgctgat 73141 aacggatggc tgctcaaacc atggggaaga cccgcttgca atggctgctt ttgctaaaga 73201 gcaggggatt acggtaaatg tcattggtat aatggaagaa aatcaaattg accctgaggc 73261 aatgaaggaa gtcgaaggga ttgcacttgc cggaggaggc gtgcaccaag tcgtttatgc 73321 atctcagctt tcacaaactg ttcaaatggt aacaaagaaa gcgatgacgc aaaccttaca 73381 aggtgtagtc aatcaagaac tgaaacagat tctcggaaag aatgtggaaa tggaagagct 73441 ttctccggaa aaacgcggcg aagtcatgga agtggtagac gagcttggag aaacggtgca 73501 tcttcaggtt ttggttcttg ttgatacaag tgcaagtatg gcgccaaagc ttccaacagt 73561 aaaagaggcg ctgattgatt tgtctgtaag cctcaattcc cgaattggga ataacgaatt 73621 tgcgatgtgt atatttcccg ggaaaaaaca agaggtcgag cttgtgctga actggacacc 73681 gaagctgcaa tctctttcca cactctttgc aaagctttcg acaggcggca tcacgccgac 73741 aggtccggcg attcgtgaag cgacactgca gtttgaaaaa atacgctcaa gaaggggcat 73801 gctggcagat gatgaacgac gctttgacga gtttggcatg tagcctcaag ccgggtacga 73861 caatcaaagg caagtggaat ggaaacactt atacattgcg taaacagctt ggtaaagggg 73921 ccaatggaat tgtgtatttg gcagaaacat cagatggaca tgttgcctta aaggtgagtg 73981 atgacagcct gtctattact tctgaagtga atgtcttgaa atctttctca aaggcccagt 74041 ccgttacgat ggggccttct ttttttgata cggatgatgc ctatattccc agtgccaata 74101 cgaaagtttc attttatgca atggaataca taaaagggcc gctgcttttg aagtatgtca 74161 gtgataaagg agcagagtgg ataccggtat taatgattca gctgttatcc agcttatcgg 74221 tgcttcacca gcaaggatgg atattcggcg atcttaaacc tgataatctg atcgtaactg 74281 gtccgcccgc aaggatccgc tgcattgatg tgggcggcac gacaaaggaa ggccgggcga 74341 taaaagagta tacggagttt tatgacagag gctattgggg gtatggaaca agaaaggcag 74401 agccatccta tgatctgttc gcagttgcca tgattatgat caacagtgtg cataaaaaag 74461 aatttaagaa aacgaaccag cccaaagaac agcttaggtc tctcatcgaa ggaaacccgc 74521 tgcttcaaaa gtataaaaaa gcgctttttt cagccttgaa cggagattat caatccgcag 74581 atgaaatgaa aaaggatatg ctagacgcgg ggcaaaaagc agcacaaaga aaacagccta 74641 taaaagcatc accgcagcct gccacacgac aaagacagca aaaaccgcgc caaggaaaaa 74701 taacgaagac gcgatatacc ccaaaacaga aaccggctaa gtcggggggg ttatttgaaa 74761 caacgcttat cgtgatcagt gttttagcgc tttatttcgc ctatattatc tttttcttaa 74821 tctgaatggt gcaaactgca gagcctatgc ttcttctttg cttggagggg ttgaaagtgt 74881 taggatatga atatctttaa aatacctgct cattgtgagg aggacattgt gaaaagtgtc 74941 aaagattttt taaacaaaca caatcttacg ttaaaagggg cgacaatcat tgtaggcgtt 75001 tccggcggtc cggactcaat ggctcttctt cacgcgttgc atacgttatg cggccgttca 75061 gcgaatgtta ttgcagctca cgttgaccat cggttcagag gtgcggaatc cgaggaggac 75121 atgcgttttg tccaagctta ttgtaaagct gaacagctcg tgtgcgaaac ggctcaaatc 75181 aatgtaaccg catatgcaca ggaaaaagga ctcaataagc aggctgcagc acgcgattgc 75241 cgctaccagt tttttgagga aatcatgtcg aagcaccaag cggactatct ggctcttgcg 75301 catcatggtg atgaccaggt tgaaacaatg cttatgaaac tggctaaggg tacgcttgga 75361 acgggacttg cgggaatgca gccggttaga cgttttggga cagggcggat catcaggccg 75421 ttcttaacca ttacaaagga agagatcctt cactattgcc atgaaaacgg cttgagctac 75481 cggacggatg aaagcaacgc caaagatgac tacacaagaa acagattcag aaaaacagtg 75541 ctcccgtttt tgaagcagga atctccggat gtgcataaaa ggtttcagaa agtgagtgaa 75601 gcactgacgg aagatgagca attcttacag tcattaacga aagatgaaat gaataaagta 75661 atcacaagcc agtctaatac atcagttgaa atcaattcct ctcaattgct tgccctcccg 75721 atgcctttac aaagaagagg agttcaacta atattaaact atctttatga aaacgttcca 75781 tcatcctttt cagcccatca cattcagcag tttctcgatt gggcggaaaa tggcggtcct 75841 tcaggagtac tggactttcc gaaagggctg aaggtggtca aatcatatca gacatgtttg 75901 tttacatttg aacaatggca gtgcaaaaat gttccctttg aataccaaat tagcggagct 75961 gctgatgaaa cggcagtgct ccctaatgga tatctgatag aggcaaggca ttatgcggac 76021 tcgcctgaag aacatgggaa tgctgttttt atcacaagtg aaaaaaaggt gcgatttccc 76081 ttaacaatcc ggacgagaaa agctggagac cggatcaaac taaaagggat gaacggctca 76141 aaaaaggtaa aggatatatt tattgataag aaattgcctc tccaagaaag agacaactgg 76201 ccgattgtga cggacgcaag cggtgaaatt atctggatac ctggcttgaa aaaatcaatt 76261 tttgaagatc ttgtgattcc aaacagcgac cgcattgtat tacaatatag acagcatgaa 76321 aagtgtaggg ggcaagcaaa atcatgatga aacatgatat cgagaaagta ctgatctcag 76381 aggaagagat acaaaagaaa gtaaaagagt taggtgcaga attaacgagc gagtatcaag 76441 atacatttcc gttggcaatc ggtgtgttaa aaggagcact tccttttatg gcggatctta 76501 tcaagcatat tgatacatat ttggaaatgg atttcatgga tgtatcaagc tacggaaatt 76561 ctacggtttc ttctggagaa gtaaaaatca ttaaagattt ggatacatct gtagagggcc 76621 gggacatctt aattattgaa gatatcatcg acagtgggtt aaccttaagt tatctcgtag 76681 agctcttccg ataccgtaaa gcaaaatcaa ttaagattgt tacccttttg gataaaccga 76741 gcggaagaaa agcggacatc aaagcagact ttgtcggttt tgaagttcct gacgcgtttg 76801 tagtgggtta cggacttgat tatgctgagc gctatcgcaa tctgccttat atcggagtgt 76861 taaaaccggc agtttatgaa agctgatcgg cagcctgctt ccgagatggt tattgtttgt 76921 attggaatga ttttctatgg tactattgaa catagttgtg cttactgtgg gaggaggtaa 76981 ggaatgaatc gggtcttccg taataccatt ttttatttac ttattttatt agtagtaatc 77041 ggggttgtga gctacttcca gacctcaaat ccgaaaacag aaaatatgtc gtacagtacg 77101 ttcatcaaaa acctggatga cgggaaagtt gatagcgtat cggttcagcc tgtcagaggt 77161 gtttatgagg taaaagggca gctgaaaaac tacgacaaag atcaatactt tttgactcat 77221 gttcctgaag gaaagggagc agaccagata tttaacgctt tgaaaaagac agacgtaaag 77281 gttgagcccg cgcaagaaac aagcggatgg gtgacgttcc tgacgaccat catcccattt 77341 gtcattatct ttattctgtt tttcttcctg ctcaatcagg ctcaaggcgg cggcagccgt 77401 gtcatgaact ttggcaagag taaagcgaag ctgtatacag aggaaaagaa acgcgtcaaa 77461 tttaaagacg ttgcaggggc tgacgaagaa aagcaagaac ttgttgaagt tgttgagttt 77521 ctgaaagatc cccgcaagtt tgccgagctc ggcgccagaa taccgaaagg cgtgctttta 77581 gtcggacctc cgggtaccgg taaaacattg cttgccaagg cttgtgcagg agaagccggc 77641 gtacctttct tcagcatcag cggatctgat ttcgttgaaa tgtttgtagg ggtcggtgct 77701 tcccgtgtgc gtgacttgtt tgaaaatgcg aaaaagaatg cgccttgttt gatcttcatt 77761 gatgaaattg acgcagtcgg acgccagcgt ggcgctggtc tcggcggtgg acacgatgaa 77821 cgtgaacaga cgctaaacca attgcttgtt gaaatggacg gattcagcgc taatgaagga 77881 attatcatca ttgctgcgac gaaccgtgcg gacatcttgg acccagcctt acttcgtccg 77941 ggacgttttg accgtcaaat cacagtggac cgcccagatg tcattggccg tgaagctgta 78001 ttgaaagtcc atgcgagaaa caaaccgctg gatgaaacgg ttaacctaaa atcaattgcc 78061 atgagaacac caggcttctc aggcgctgac ttagaaaacc tcttgaatga agctgcgctt 78121 gtagcggctc gtcaaaacaa gaaaaaaatc gatgcgcgtg atattgacga agcgacggac 78181 cgtgtaattg ccggacccgc taagaagagc cgcgttatct ccaagaaaga acgcaatatc 78241 gtggcttatc acgaaggcgg acacaccgtt atcggtctcg ttttagatga ggcagatatg 78301 gttcataaag taacgattgt tcctcggggc caggctggcg gttatgctgt tatgctgcca 78361 agagaagacc gttatttcca aacaaagccg gagctgcttg ataaaattgt cggcctcttg 78421 ggcggacgtg ttgctgaaga gattatcttc ggtgaagtca gcacaggggc gcacaatgac 78481 ttccagcgtg cgacgaatat tgcaagacga atggttacag aattcggtat gtcagaaaaa 78541 ctgggaccgt tgcaatttgg acagtctcag ggcggtcagg tattcttagg ccgtgatttc 78601 aacaacgaac agaactacag tgatcaaatc gcttacgaaa ttgatcagga aattcagcgc 78661 atcatcaaag aatgttatga gcgtgcgaaa caaatcctga ctgaaaatcg tgacaagctt 78721 gaattgattg cccaaacgct tctgaaagtt gaaacgcttg acgctgaaca aatcaaacac 78781 cttatcgatc atggaacatt acctgagcgt aatttctcag atgatgaaaa gaacgatgat 78841 gtgaaagtaa acattctgac aaaaacagaa gaaaagaaag acgatacgaa agagtaattc 78901 gctttctttc taaaaaaact gccggctgac gctggcagtt tttttatgta aatgattggc 78961 tcagctgcgg cttttacaat catccaattc tggtatcgat ttgtttacaa atgagccgct 79021 gatcgtgtat ggtattgtag aatgtttgta aaaagtaaag tagagaaact attcaaaagt 79081 ggtgatagag gttgttactg gttatcgatg tggggaacac caatactgta cttggtgtat 79141 atcatgatgg aaaattagaa tatcactggc gtatagaaac aagcaggcat aaaacagaag 79201 atgagtttgg gatgattttg cgctccttat ttgatcactc cgggcttatg tttgaacaga 79261 tagatggcat tattatttcg tcagtagtgc cgccaatcat gtttgcgtta gaaagaatgt 79321 gcacaaaata ctttcatatc gagcctcaaa ttgttggtcc aggtatgaaa accggtttaa 79381 atataaaata tgacaatccg aaagaagtag gggcagacag aatcgtaaat gctgtcgctg 79441 cgatacactt gtacggcaat ccattaattg ttgtcgattt cggaaccgcc acaacgtact 79501 gctatattga tgaaaacaaa caatacatgg gcggggcgat tgcccctggg attacaattt 79561 cgacagaggc gctttactcg cgtgcagcaa agcttcctcg tatcgaaatc acccggcccg 79621 acaatattat cggaaaaaac actgttagcg cgatgcaatc tggaatttta tttggctatg 79681 tcggccaagt ggaaggaatc gttaagcgaa tgaaatggca ggcaaaacag gaaccaaagg 79741 tcattgcgac aggaggcctg gcgccgctca ttgcgaacga atcagattgt atagacatcg 79801 ttgatccatt cttaacccta aaagggctgg aattgattta tgaaagaaac cgcgtaggaa 79861 gtgtatagga ggtttagtaa tggattattt agtaaaagca cttgcgtatg acggaaaagt 79921 tcgggcttat gcagcgagaa cgactgatat ggtaaatgag gggcagagac gccatggtac 79981 gtggccgaca gcatccgctg cactaggccg tacaatgaca gcttcactta tgctcggcgc 80041 tatgctgaag ggcgatgata agctgaccgt gaaaatcgag ggcggaggtc cgatcggagc 80101 tattgtagct gatgccaatg ccaaaggaga agtcagagcc tatgtctcta acccgcaagt 80161 tcattttgat ttaaatgaac aaggtaagct tgatgtcaga cgtgcggttg gaacaaacgg 80221 aacgttaagt gtcgtaaaag atttaggttt gcgcgagttc ttcacaggac aagtagaaat 80281 cgtttcagga gaattaggag atgattttac ttactatctt gtgtcatctg agcaggttcc 80341 ttcatcagtg ggcgtaggtg tgctcgtaaa tcctgacaat accattcttg cggcaggggg 80401 ctttattatt cagctgatgc cgggaacaga tgatgaaaca atcacaaaaa ttgaacagcg 80461 tctatctcaa gtagagccga tttctaagct catccaaaaa gggctgacac cagaagaaat 80521 tttagaagaa gtcctaggcg agaaacctga gattttggaa acgatgcctg tcagattcca 80581 ttgcccttgt tcaaaagaac ggttcgaaac agccatttta ggactaggca aaaaagaaat 80641 tcaagatatg atagaagaag atggacaagc cgaagcagta tgccattttt gtaatgaaaa 80701 gtacttattt acaaaagaag agctggaagg gcttcgtgac caaactaccc gctaagctct 80761 ttagcgggtt tttaatttga gaaaaggggc tgaaagcagg tttgaaatca agaacaatct 80821 ggaccattat tttaggggcg ctgttggttt gctgtattgc tgttgcatat acgctgacga 80881 aatcccaagc cggcgcatcg tcatccggtg agtctattgc gactatcgga ggcaagagtg 80941 tgacaagaga agaatggctg aaagaaatgg aagatcagta tggtaagtca acgcttgaag 81001 atatgatcaa tgtccgagtt gttgagcagc tggctaaaaa gaacaaactt aaaatatcca 81061 aaagcgaagt tgatcgtgag tttttgctga ttaaagcggt caataattcc ttttacgaag 81121 atgaacatac gacggagaaa gagtggaaag accaaattcg ttataatatc ctccttgagg 81181 atttgttaac aagggatatc gatatctcaa acaaagaatt ggaatcattc tataataaaa 81241 ataaggaact atatcagttt gatgattcgt atcgaattcg gcacattgtt gtaaaagatg 81301 aagaagaagc aagagaagtc ctgaaagaac tgaaaggcgg atcaagcttt gaagctgtcg 81361 ctgccgaaag atctacagac agatatacat caccatacgg cggagattta ggttttgtca 81421 cagaggcatc agacaacatt ccatcagcat acattgaaga ggcgaaaaca ctcaaagagg 81481 atgaatggtc tcaggaacca ataaaggtca gcaacggata tgccattatc cagctgaaag 81541 aaaaactaaa ggcaagaacg ttctcatttg atgaagtaaa ggaccagatc agacggcaaa 81601 tcgcaatgga tcagctaggc gataaagcga cagttaagac actttggaaa gaagccgatg 81661 tatcttggtt ttatggggaa aaaagtacta agtgattgac aaaaaatttt gaaattgata 81721 gattatatac ataataccaa tacaaatagt cggaaattga ggtgtcgaga atggtacgtg 81781 tagcaaactc cattactgaa ttaattggga atacgccaat cgttaaatta aatcgccttg 81841 cagatgaaaa cagtgcggat gtatatctaa aacttgaata catgaaccct ggaagcagtg 81901 taaaagaccg tatcggttta gctatgattg aagcggctga aaaagaagga aaattaaaag 81961 ccggtaatac aatcattgaa ccgacaagcg gaaatactgg aatcgggctt gcaatggttg 82021 ctgctgctaa aggattaaaa gccattttgg ttatgcctga tacaatgagc atggagcgcc 82081 gcaaccttct tcgcgcatat ggtgctgagc ttgtgctgac tcctggtgcg gaaggcatga 82141 aaggtgctat taagaaagct gaagagcttg ctgaaaagca cggatacttt gtgccgcagc 82201 agtttaacaa cccttctaac cccgaaattc accgccaaac aacgggtaaa gaaatcgttg 82261 agcaattcgg tgatgatcag cttgacgcat ttgtagccgg aatcggaacg ggcggaacga 82321 ttacgggagc gggcgaagtg ctgaaggaag catacccttc catcaagatt tatgctgttg 82381 aaccgtcaga ttccccagtg ctttcaggag gaaaaccagg cccccacaaa attcagggaa 82441 tcggagcagg attcgtgccg gacatcttaa acactgaagt atatgatgaa atcttccctg 82501 tgaagaatga agaagcattc gaatatgccc gcagagctgc acgtgaagaa ggaattctcg 82561 gaggcatctc atcaggtgcg gcaatttatg ctgctcttca agtagcaaaa aaactcggaa 82621 aaggcaaaaa agtattggcc atcattccaa gtaacggcga acgttatcta agcacgccgc 82681 tgtaccaatt cgattaaaaa aagccaaaac tcccggttcg ccgggagttt ttttatattt 82741 cgtgcatcaa atatgccatg tctgcgacga atgttattct tggaagagaa attcactttt 82801 ttcactaaca acattgcttt acaattaaaa acaagtaaaa aagaaaatag aggaatgata 82861 caaatggcac aacgcagacc ggcaggcaaa aaaatacctt ttcaaaaaga ctcattctta 82921 caacaatttg agaaacttgc gcaatcccgg aaacatcatg tacttctcga aagtgcaaga 82981 ggcggcagat atagtatagc cggtcttgat ccaattgcga ctgtgaaagg aaaagacgga 83041 ataactacaa ttaagcatgg tgatgagatg ctgtttaaag aaggtgatcc attacgggcc 83101 ttccacagct ggtttaaaac actggaaaca gaaacgaatc atgagttccc tgactttcaa 83161 ggcggggcaa tcgggtttct cagctatgat tacgcacggt acattgaaaa ttttaaaatg 83221 ctctcattag atgatttaga aacaccagat atttattttc ttgtttttga tgatatagca 83281 gtttatgacc atcaagaaga gtctctatgg ctgattactc atgttaatgg ttctgatcag 83341 gaaacagcgg atgtgaagct atctgagtta gagcagatgt ggttgactga gcttcccgct 83401 gtcacttcgc gagagatgaa gcctgaaaca gctggttctt tcgcggcgcc atttaccgag 83461 gatgggttct cacaagctgt agagaaaatc aaacaataca ttgccagcgg agatgtgttt 83521 caagtcaatc tatcaataag gcagtcacag tcactgtctg tccacccata tcaaatttac 83581 aaaaccttga gagaagtaaa tccttctcct tatatggcgt atttagaaac acctgatttc 83641 caaatcattt gcggatcgcc tgaactgctt gtcagcaaaa agggcaagct attagagacg 83701 agaccgattg cgggcacccg ttccagaggg aaaacaaatg aagaagacga ggcgcttgca 83761 aacgaattga tacacaatga aaaagaacgc gcggaacatg tcatgctggt tgatcttgag 83821 cgaaatgatc tgggaagagt atcacgttac gggtctgtgc gcgtaaatga attcatggca 83881 attgaaaaat actcgcatgt gatgcacatt gtgtctaatg tccaaggtga actgcaggat 83941 gggtatgatg ctgtagatat tattcatgct gtgtttcccg gaggaaccat tactggtgca 84001 ccgaaagtaa gaacgatgga aattatagaa gaacttgagc cgacacgccg agggctttat 84061 actggatcta taggatggtt tggatataat cacgatctgc agtttaatat cgtcattcga 84121 accatttatg caaccggagg gcaggcattt atgcagtccg gtgcaggagt tgtgattgat 84181 tctgttccga agcacgaata caaggaatca ttcaaaaaag cttttgcgat gcaaagagca 84241 ttagagctga gcgaagaaga gacaaaaatt agatgaggtg agcggagaaa tgattttaat 84301 gattgataac tacgattcat tcacgtacaa cttggtacag tatttgggcg agcttgggga 84361 agagctggtt gtgaaacgca atgacagcat cacaatcgat gaaattgaag aactgtctcc 84421 ggactttctg atgatatctc ccggaccgtg cagccctgat gaggcgggaa tcagcctcga 84481 agcaattaaa catttcgcag ggaaaattcc tattttcggt gtatgtctcg gacatcagtc 84541 catcgcacaa gtgttcggtg gtgatgttgt tagggcagaa cggcttatgc acgggaaaac 84601 ctcggatatc gagcatgacg gcaaaaccat ttttgaaggg ttgaaaaatc cccttgttgc 84661 gacgcgatac cactcgctga tcgtaaaacc tgagacgctg ccaagctgtt ttacagtaac 84721 agcacaaacg aaagaaggag aaatcatggc tattcgccac aatgacctcc cgatagaggg 84781 tgtgcaattt cacccagagt ctattatgac ctcctttggg aaagaaatgc tcagaaattt 84841 tattgagaca tatcgcaagg aagttattgc gtgatgatat atgtgaacgg ccggtatatg 84901 gaggagaaag atgcagttct ttctcctttt gaccatgggt ttttatatgg gatcggtgtt 84961 ttcgaaacct tcaggctcta cgaaggctgc ccgtttttgc ttgattggca tatagagagg 85021 cttgaacgcg cgcttaagga tctgcaaatc gaatatactg tttcaaagca tgagatcctt 85081 gagatgctgg acaagctgct taagctaaat gatatcaagg atggcaatgc ccgcgtcaga 85141 ctgaacatat cagcgggaat cagcgataaa ggctttgtcg cccagacgta cgataagccc 85201 accgttttat gctttgtgaa tcagctgaaa ccagaaagtc ttcctttgca aaaagaagga 85261 aaggttttat cgatacggag aaacactcca gagggatcgt tccggttaaa atctcatcat 85321 tatctaaata atatgtatgc gaaacgggaa attggaaatg atccgcgtgt cgagggaatt 85381 ttcttaacgg aggatggagc tgttgcagag ggtatcatat ctaatgtctt ctggagaaaa 85441 ggtcgctgta tctatacgcc atcgcttgat accggtattc tggacggcgt cacgagacgt 85501 tttatcatag aaaatgcaaa ggatatcggc ctggagctca aaacgggccg atatgagcta 85561 gaagctctct tgacagctga cgaagcgtgg atgacgaact cggttcttga aatcatcccg 85621 tttactaaaa tagaagaagt aaactatgga agccaaagcg gagaagcaac ctccgctctt 85681 caattgttat acaaaaaaga aataaagaac atgattcatg aaaagggagg aagagcatgg 85741 cgcagcacac aatagatcaa acacaagtaa tccacactaa gcccagcgct ttatcatata 85801 aagagaagac gctggtgatg ggaattttaa acgtaacgcc tgactctttc tcggacggcg 85861 gaaaatatga cagcttggac aaggcgctgc tgcacgcgaa agagatgatc gatgatggtg 85921 cccatatcat tgatattgga ggggaatcga caaggcctgg cgctgagtgc gtatctgagg 85981 atgaggagat gtccagagtc attccggtga ttgagcggat tacgaaagag cttggtgttc 86041 ctatttctgt agacacgtac aaggcttctg tcgcagatga agcagtgaaa gccggtgcat 86101 ccattatcaa tgatatttgg ggagccaaac atgatccgaa gatggcttcc gttgcagctg 86161 aacataatgt tccaattgta ctcatgcata accgccctga aagaaactac aatgacttat 86221 tgccggatat gctgtcggac ttaatggaga gtgtaaaaat tgctgttgag gccggagtag 86281 acgagaagaa cattattctt gatcctggta tcggtttcgc gaaaacctat cacgataact 86341 tggcagtgat gaacaaacta gagattttca gcggattggg atatccggtt cttctggcaa 86401 cctcccgaaa aagattcatc ggacgtgttc tggatcttcc gcctgaggag cgggctgagg 86461 gcacaggcgc gactgtgtgt ctcggcattc aaaaaggctg tgacattgtc agggtccatg 86521 atgtaaagca aattgccaga atggcgaaaa tgatggacgc gatgctgaat aagggagggg 86581 tgcaccatgg ataaagttta tgtagaaggt atggagtttt acggatatca cggtgtgttc 86641 acagaagaaa acaaacttgg ccagcggttt aaagtcgatt taaccgctga gctggattta 86701 agcaaagctg gacagacaga cgaccttgag caaacgatca actatgctga gctctatcac 86761 gtatgtaaag atatcgtgga aggggagcct gtgaaattgg tggaaacgct ggcggaacgt 86821 attgctggca ctgttctcgg aaaatttcag cctgttcagc aatgtacggt gaaagtgatt 86881 aagccagacc cgccaattcc cggacactat aaatcagtag caattgaaat tacgagaaaa 86941 aagtcatgaa caacatagct tatattgcac ttggatctaa tattggagat agagaaacgt 87001 atttaaggca agcagtggct ttactgcatc agcatgctgc ggtgacagtc actaaagtgt 87061 cgtctattta cgaaactgac ccggtcggat acgaagatca agctcaattt ttgaatatgg 87121 ctgttgaaat caagacatca ttgaaccctt ttgaactcct tgaactgacg cagcagatag 87181 aaaatgaatt aggcagaaca agggaagtaa gatgggggcc gcggacggca gaccttgaca 87241 ttttgttatt taatcgtgaa aatattgaaa cagagcaact aattgttccg catccgagaa 87301 tgtatgagcg tttgtttgtc cttgcgccgc ttgcggaaat ttgccagcag gttgaaaaag 87361 aggctacaag cgccgaaaca gaccaagaag gtgtaagagt atggaagcag aaatctgggg 87421 tagacgaatt cgtgcattca gaaagctgaa aggttatact caagaaggat ttgcaaaagc 87481 attaggtata tcagtttcta ttctcggcga aattgaacgc ggaaaccgat tgccgtctgc 87541 tgccatcatt caagatgcag cagatgtttt aaatataagt gcggacgaat tggcgccgcc 87601 agaaaaatag aacaaatgaa aggaggagaa aaattgttca aaatcggaga tattcaattg 87661 aaaaaccggg ttgtgctcgc acctatggct ggtgtctgca actctgcgtt cagattgact 87721 gtaaaggaat tcggagccgg attggtatgc gctgaaatgg tcagtgacaa agcgatcctt 87781 tacaacaatg caagaacaat gggtatgctt tatattgatg aacgtgagaa accactgagc 87841 cttcaaattt tcggaggaaa aaaggaaacc cttgtggaag cggcgaagtt tgtagaccaa 87901 aacacaactg ctgatatcat tgatattaac atgggatgtc ccgtgccgaa gattacaaaa 87961 tgcgatgcgg gagccaaatg gcttctcgat cctgataaga tttacgaaat ggtttctgca 88021 gtagtggatg ctgttaataa gccagttaca gtgaaaatga gaatgggctg ggatgaagac 88081 cacattttcg cagtgaaaaa tgcacaggct gtagaacgtg cgggcggtaa agcagtggcg 88141 cttcacggcc gtacgagagt gcagatgtac gaaggaacgg caaactggga tatcatcaaa 88201 gaagtaaaac aatcagtatc gattccggtt atcggaaacg gcgatgttaa gacaccgcag 88261 gatgctaagc gtatgctcga tgagacagga gtagacgggg tcatgatcgg acgcgctgca 88321 ttgggtaacc cgtggatgat ttaccgtacg gttcagtatc ttgaaacagg taaattaaaa 88381 gaagagccgc aagtacgcga aaaaatggcc gtatgcaaac tgcatcttga ccgcctgatt 88441 gacttaaaag gtgaaaacgt agcggtaaga gaaatgagaa agcacgctgc atggtatctg 88501 aaaggcgtga aaggcaatgc gaacgttcgt aatgaaatca atcattgcga gacgagagaa 88561 gagtttgtac agcttttaga tgcatttacg gttgaagttg aggcaaaaga gcttcaaaat 88621 gcaaaagtag gataatactc acctctattt gctgctcact gctagtttta cgctggcagt 88681 ttttctgctt ttttcatgaa acaatatctg taatggagtg ataacaatga gtcaagaaga 88741 gcataaccat gaagaattga atgatcagct gcaagtcaga cgcgataaaa tgaatcagct 88801 gagagataac ggcatcgatc cattcggcgc acgttttgaa agaactcatc agtctcaaga 88861 agttatttcg gcatatcaag atctaaccaa agaagagtta gaagaaaaag cgattgaagt 88921 tacaatcgca ggccgcatga tgacaaaacg cggcaaagga aaagccggct ttgcccatct 88981 tcaggattta gaaggccaaa tccaaatcta cgtaagaaaa gacagtgtcg gtgacgacca 89041 atatgaaatc ttcaagtctt ctgacctcgg tgatcttatc ggcgtaaccg gaaaagtctt 89101 caaaacaaat gtaggcgaat tgtctgttaa agcaacttcc tttgaattgc tgacaaaagc 89161 gcttcgtccg cttcctgaca aataccatgg tttaaaagac gttgagcagc gctaccgtca 89221 gcgctatctg gatcttatcg taaacccaga cagcaaacat acgttcatta cacgaagcaa 89281 gatcattcaa gctatgagaa ggtaccttga tgatcatgga tacttagaag tagaaacacc 89341 tacaatgcac agcattcctg ggggagcttc tgcacgtccg tttatcactc accacaacgc 89401 gttagacatt ccactctata tgcgtattgc tatcgaactg cacctaaaac gtctaattgt 89461 cggcggttta gaaaaagtat atgaaatcgg ccgtgttttc cgtaacgaag gtgtctctac 89521 acgccataac cctgaattta caatgattga gttatatgaa gcatatgcgg actataaaga 89581 tatcatgagc ttaactgaaa accttgtcgc tcatatcgcc caagaagtgc ttggcacaac 89641 tacgattcaa tacggggaag agcaaatcga ccttaaaccg gagtggaaaa gaatccatat 89701 ggttgacgca gtcaaagaag cgaccggcgt tgatttctgg gaagaggtta ctgttgagca 89761 ggcgcgtgaa tatgcaaaag aacatgaagt agaaattaaa gactctatga cagtaggcca 89821 tatcatcaac gaattcttcg aacaaaaaat tgaagaaacg cttattcagc caacgtttat 89881 ttacgggcat cctgtagaaa tttctcctct tgctaagaaa aaccctgagg acccgcgttt 89941 tacagaccgt tttgagctgt ttatcgttgg ccgtgaacat gccaacgcgt ttacagagct 90001 gaatgatcct attgatcaaa gagaacgctt tgaagcgcaa ttaaaagagc gtgaagccgg 90061 taatgatgaa gctcatttaa tggatgaaga ctttgttgaa gctctggaat acggtatgcc 90121 gccaacagga ggtttaggca tcggtatcga ccgtctggtt atgctgctga cgaatgcccc 90181 ttctattcgc gatgtgctgt tattcccgca aatgagacaa cgctaataaa aaagagcggt 90241 atcctccata gggaaaggat gccgctcttt ttaaatccct tagtatttct tcaaaaaaac 90301 tattgcacta ttatttacta ggtggtatat tattattcgt tgccgctaaa caaggcgata 90361 acgaaaaaaa gaacttcaaa aaaagttatt gacttcactg agtcaacgag ttataataat 90421 aaagtcgctt gaacgaagtg aacaaaatga tctttgaaaa ctaaacaaga caaaacgtac 90481 ctgttaattc agtttttaaa aatcgcacag cgatgtgcgt agtcagtcaa actactttat 90541 cggagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac atgcaagtcg 90601 agcggacaga tgggagcttg ctccctgatg ttagcggcgg acgggtgagt aacacgtggg 90661 taacctgcct gtaagactgg gataactccg ggaaaccggg gctaataccg gatggttgtt 90721 tgaaccgcat ggttcaaaca taaaaggtgg cttcggctac cacttgcaga tggacccgcg 90781 gcgcattagc tagttggtga ggtaatggct caccaaggca acgatgcgta gccgacctga 90841 gagggtgatc ggccacactg ggactgagac acggcccaga ctcctacggg aggcagcagt 90901 agggaatctt ccgcaatgga cgaaagtctg acggagcaac gccgcgtgag tgatgaaggt 90961 tttcggatcg taaagctctg ttgttaggga agaacaagtg ccgttcgaat agggcggtac 91021 cttgacggta cctaaccaga aagccacggc taactacgtg ccagcagccg cggtaatacg 91081 taggtggcaa gcgttgtccg gaattattgg gcgtaaaggg ctcgcaggcg gtttcttaag 91141 tctgatgtga aagcccccgg ctcaaccggg gagggtcatt ggaaactggg gaacttgagt 91201 gcagaagagg agagtggaat tccacgtgta gcggtgaaat gcgtagagat gtggaggaac 91261 accagtggcg aaggcgactc tctggtctgt aactgacgct gaggagcgaa agcgtgggga 91321 gcgaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct aagtgttagg 91381 gggtttccgc cccttagtgc tgcagctaac gcattaagca ctccgcctgg ggagtacggt 91441 cgcaagactg aaactcaaag gaattgacgg gggcccgcac aagcggtgga gcatgtggtt 91501 taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctctgaca atcctagaga 91561 taggacgtcc ccttcggggg cagagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc 91621 gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gatcttagtt gccagcattc 91681 agttgggcac tctaaggtga ctgccggtga caaaccggag gaaggtgggg atgacgtcaa 91741 atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggacaga acaaagggca 91801 gcgaaaccgc gaggttaagc caatcccaca aatctgttct cagttcggat cgcagtctgc 91861 aactcgactg cgtgaagctg gaatcgctag taatcgcgga tcagcatgcc gcggtgaata 91921 cgttcccggg ccttgtacac accgcccgtc acaccacgag agtttgtaac acccgaagtc 91981 ggtgaggtaa ccttttagga gccagccgcc gaaggtggga cagatgattg gggtgaagtc 92041 gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc tcctttctaa ggatatttta 92101 cggaatataa gaccttgggt cttataaaca gaacgttccc tgtcttgttt agttttgaag 92161 gatcattcct tcgaaacgtg ttctttgaaa actagataac agtagacatc acattcaagt 92221 aatacaagat atcacatagt gattcttttt aacggttaag ttagaaaggg cgcacggtgg 92281 atgccttggc actaggagcc gatgaaggac gggacgaaca ccgatatgct tcggggagct 92341 gtaagcaagc tttgatccgg agatttccga atggggaaac ccaccactcg taatggagtg 92401 gtatccatat ctgaattcat aggatatgag aaggcagacc cggggaactg aaacatctaa 92461 gtacccggag gaagagaaag caaatgcgat tccctgagta gcggcgagcg aaacgggatt 92521 agcccaaacc aagaggcttg cctcttgggg ttgtaggaca ctctgtacgg agttacaaag 92581 gaacgaggta gatgaagagg tctggaaagg cccgccatag gaggtaacag ccctgtagtc 92641 aaaacttcgt tctctcctga gtggatcctg agtacggcgg aacacgtgaa attccgtcgg 92701 aatccgggag gaccatctcc caaggctaaa tactccctag tgaccgatag tgaaccagta 92761 ccgtgaggga aaggtgaaaa gcaccccgga aggggagtga aagagatcct gaaaccgtgt 92821 gcctacaagt agtcagagcc cgttaacggg tgatggcgtg ccttttgtag aatgaaccgg 92881 cgagttacga tcccgtgcaa ggttaagcag aagatgcgga gccgcagcga aagcgagtct 92941 gaatagggcg catgagtacg tggtcgtaga cccgaaacca ggtgatctac ccatgtccag 93001 ggtgaagttc aggtaacact gaatggaggc ccgaacccac gcacgttgaa aagtgcgggg 93061 atgaggtgtg ggtaggggtg aaatgccaat cgaacctgga gatagctggt tctctccgaa 93121 atagctttag ggctagcctc aaggtaagag tcttggaggt agagcactga ttggactagg 93181 ggcccctacc gggttaccga attcagtcaa actccgaatg ccaatgactt atccttggga 93241 gtcagactgc gagtgataag atccgtagtc gaaagggaaa cagcccagac cgccagctaa 93301 ggtcccaaag tatacgttaa gtggaaaagg atgtggagtt gcttagacaa ccaggatgtt 93361 ggcttagaag cagccaccat ttaaagagtg cgtaatagct cactggtcga gtgactctgc 93421 gccgaaaatg taccggggct aaacgtatca ccgaagctgc ggactgttct tcgaacagtg 93481 gtaggagagc gttctaaggg ctgtgaagcc agaccggaag gactggtgga gcgcttagaa 93541 gtgagaatgc cggtatgagt agcgaaagag gggtgagaat cccctccacc gaatgcctaa 93601 ggtttcctga ggaaggctcg tccgctcagg gttagtcggg acctaagccg aggccgaaag 93661 gcgtaggcga tggacaacag gttgatattc ctgtaccacc tcctcaccat ttgagcaatg 93721 gggggacgca ggaggatagg gtaagcgcgg tattggatat ccgcgtccaa gcagttaggc 93781 tgggaaatag gcaaatccgt ttcccataag gctgagctgt gatggcgagc gaaatatagt 93841 agcgaagttc ctgattccac actgccaaga aaagcctcta gcgaggtgag aggtgcccgt 93901 accgcaaacc gacacaggta ggcgaggaga gaatcctaag gtgatcgaga gaactctcgt 93961 taaggaactc ggcaaaatga ccccgtaact tcgggagaag gggtgctctg ttagggtgca 94021 agcccgagag agccgcagtg aataggccca ggcgactgtt tagcaaaaac acaggtctct 94081 gcgaagccgt aaggcgaagt ataggggctg acgcctgccc ggtgctggaa ggttaagagg 94141 agcgcttagc gtaagcgaag gtgcgaattg aagccccagt aaacggcggc cgtaactata 94201 acggtcctaa ggtagcgaaa ttccttgtcg ggtaagttcc gacccgcacg aaaggcgcaa 94261 cgatctgggc actgtctcaa cgagagactc ggtgaaatta tagtacctgt gaagatgcag 94321 gttacccgcg acaggacgga aagaccccgt ggagctttac tgcagcctga tattgaatgt 94381 tggtacagct tgtacaggat aggtaggagc cttggaaacc ggagcgccag cttcggtgga 94441 ggcatcggtg ggatactacc ctggctgtat tgaccttcta acccgccgcc cttatcgggc 94501 ggggagacag tgtcaggtgg gcagtttgac tggggcggtc gcctcctaaa aggtaacgga 94561 ggcgcccaaa ggttccctca gaatggttgg aaatcattcg cagagtgtaa aggcacaagg 94621 gagcttgact gcgagaccta caagtcgagc agggacgaaa gtcgggctta gtgatccggt 94681 ggttccgcat ggaagggcca tcgctcaacg gataaaagct accccgggga taacaggctt 94741 atctccccca agagtccaca tcgacgggga ggtttggcac ctcgatgtcg gctcatcgca 94801 tcctggggct gtagtcggtc ccaagggttg ggctgttcgc ccattaaagc ggtacgcgag 94861 ctgggttcag aacgtcgtga gacagttcgg tccctatccg tcgcgggcgc aggaaatttg 94921 agaggagctg tccttagtac gagaggaccg ggatggacgc accgctggtg taccagttgt 94981 tctgccaagg gcatcgctgg gtagctatgt gcggacggga taagtgctga aagcatctaa 95041 gcatgaagcc cccctcaaga tgagatttcc cattccgcaa ggaagtaaga tccctgaaag 95101 atgatcaggt tgataggtct gaggtggaag tgtggcgaca catggagctg acagatacta 95161 atcgatcgag gacttaacca tatttttgaa tgatgtcaca tctgttatct agttttgaga 95221 gaacactctc aatttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 95281 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 95341 acgccgccaa gcaattgcac gttagtgcaa ttatggagga ttagctcagc tgggagagca 95401 tctgccttac aagcagaggg tcggcggttc gagcccgtca tcctccacca ttatgccggt 95461 gtagctcaat tggtagagca actgacttgt aatcagtagg ttgggggttc aagtcctctt 95521 gccggcacca cttttatatg atataatact caagtctctt gtagaagagc cattagctca 95581 gttggtagag catctgactt ttaatcagag ggtcgaaggt tcgagtcctt catggctcac 95641 cattttacgc gggtgtggcg gaattggcag acgcgctaga cttaggatct agtgtcttta 95701 tgacgtgggg gttcaagtcc cttcacccgc attatatagg ataacagtta gaaaaactgg 95761 acatcctgtc tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 95821 gggttcgaat cccgtcttcc gctccaacta taccatccac gccggggtgg tggaattggc 95881 agacacacag gacttaaaat cctgcggtag gtgactaccg tgccggttca agtccggccc 95941 tcggcattat gttttgcgcc cgtagctcaa ttggatagag cgtttgacta cggatcaaaa 96001 ggttaggggt tcgactcctc tcgggcgcgc catatctttt aatagaatag ataggaaatc 96061 gggaagtagc tcagcttggt agagcacatg gtttgggacc atggggtcgc aggttcgaat 96121 cctgtcttcc cgaccatttt tttatggggc cttagctcag ctgggagagc gcctgctttg 96181 cacgcaggag gtcagcggtt cgatcccgct aggctccacc aaaagttttt aaaaaagttg 96241 ttgactttga agaagtgacg ttgtatacta ataaagttgc tttaacaaag cggacaaaca 96301 aaatgatctt tgaaaactaa acaagacaaa acgtacctgt taattcagtt tttaaaaatc 96361 gcacagcgat gtgcgtagtc agtcaaacta ctttatcgga gagtttgatc ctggctcagg 96421 acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg agcttgctcc 96481 ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata 96541 actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa 96601 aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta 96661 acggctcacc aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac 96721 tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 96781 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 96841 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 96901 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat 96961 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 97021 accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca 97081 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 97141 gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 97201 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 97261 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 97321 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 97381 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 97441 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 97501 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 97561 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 97621 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 97681 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 97741 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 97801 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 97861 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 97921 gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc ttgggtctta 97981 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 98041 ttgaaaacta gataacagta gacatcacat tcaagtaata caagatatca catagtgatt 98101 ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta ggagccgatg 98161 aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg atccggagat 98221 ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga attcatagga 98281 tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag agaaagcaaa 98341 tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga ggcttgcctc 98401 ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg aagaggtctg 98461 gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc tcctgagtgg 98521 atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc atctcccaag 98581 gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg tgaaaagcac 98641 cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc agagcccgtt 98701 aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatccc gtgcaaggtt 98761 aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg agtacgtggt 98821 cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt aacactgaat 98881 ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta ggggtgaaat 98941 gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct agcctcaagg 99001 taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt taccgaattc 99061 agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt gataagatcc 99121 gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata cgttaagtgg 99181 aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc caccatttaa 99241 agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc ggggctaaac 99301 gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc taagggctgt 99361 gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt atgagtagcg 99421 aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa ggctcgtccg 99481 ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga caacaggttg 99541 atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag gatagggtaa 99601 gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa atccgtttcc 99661 cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga ttccacactg 99721 ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca caggtaggcg 99781 aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca aaatgacccc 99841 gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc gcagtgaata 99901 ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg cgaagtatag 99961 gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa gcgaaggtgc 100021 gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta gcgaaattcc 100081 ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg tctcaacgag 100141 agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag gacggaaaga 100201 ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta caggataggt 100261 aggagccttg gaaaccggag cgccagcttt ggtggaggca tcggtgggat actaccctgg 100321 ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc aggtgggcag 100381 tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt ccctcagaat 100441 ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga gacctacaag 100501 tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa gggccatcgc 100561 tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag tccacatcga 100621 cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag tcggtcccaa 100681 gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg tcgtgagaca 100741 gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct tagtacgaga 100801 ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat cgctgggtag 100861 ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc tcaagatgag 100921 atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat aggtctgagg 100981 tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact taaccatatt 101041 tttgaatgat gtcacatctg ttatctagtt ttgagagaac actctcaatt tgtttggtgg 101101 cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc tcttcagcgc 101161 cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa gcttaaaccc 101221 agctcaatga gctgggtttt ttgtattttg gtttattggt atcataaaat tccacttaac 101281 tgtataatat aataacttta taccgaattt taaatcagca atcaggtttt gtggaccggg 101341 aaaatggaaa taatgaagga tagagcgaga aagttgaaaa ttctcgagaa acggcttata 101401 gtaagattaa agtcaaatat agtcaaagtc agtaaaggag ggggttgagt gggacataat 101461 atttctgaca tcattgaaca atatttaaaa cgagtgttag atcaaaatgg caaggaaatt 101521 ttagagatta aacgaagtga aattgcagat aaatttcaat gcgttccttc ccaaataaat 101581 tatgtcatca acaccagatt tacaagcgaa agaggatata ttgttgagag caaacgcggg 101641 ggcggcggtt acatcagaat cattaaaatt aaaatgaaca atgaagttgt cctgatcaat 101701 aatataattt ctcaaattaa tacccatttg tctcaagcag cctctgatga cattatttta 101761 aggctattag aagacaaggt aatttcagaa agagaagcaa aaatgatggt cagcgtaatg 101821 gaccgctcag ttttacacat tgacttacct gaacgtgatg aattaagagc gagaatgatg 101881 aaggcaatgc tgacttcttt aaaattaaaa taagcgggtg aaaagattga tttgtcaaga 101941 gtgccacgag agaccagcca cttttcactt tacaaaggtt gttaacggag aaaaaataga 102001 agttcatatt tgtgaacaat gtgccaaaga aaatagtgat tcatatggta taagtgcaaa 102061 tcagggtttc tctattcata atttactttc gggtttactg aacatggatt cttcatttca 102121 aaatgcagga actcaaatgt tcagtcactc ggagcaaata tctgcttgtc cgaaatgcgg 102181 aatgactttt cagcaattca gaaaaattgg ccgttttgga tgttctgaat gttacaaaac 102241 atttcatagc aacattacac caatcctacg taaagtgcac agcggaaaca ctgtgcatgc 102301 aggtaagata ccgaaacgaa taggcggcaa tcttcatgtc agacggcaga ttgatatgct 102361 aaaaaaggaa ttagaatcct taatccatca agaagaattt gaaaatgcag ctcatgtaag 102421 agatcaaatt cgtttattag aacaatcact caaaagtaca gatagtgagg aggaacagga 102481 gtaatgtcgc taaagcattt tattcaggac gcactaagca gttggatgaa gcagaaagga 102541 cctgaaagtg acattgtact cagcagccgc atacgtttag caagaaactt tgagcatatt 102601 cggttcccta cgcggtattc caatgaagaa gcctcatcca tcatacagca atttgaagat 102661 cagttttcag agcaagaaat tcccggaatc ggcaaatttg ttttgattag aatgaatgat 102721 gcacagcctt tagaaaagcg tgtacttgtt gaaaaacatc taatcagccc gaatttgaca 102781 gagtctcctt ttggcggctg tttgctttct gaaaatgagg aagtaagcgt catgctaaat 102841 gaagaggacc atattagaat tcagtgtctt ttccctggat ttcagctttt agaagcaatg 102901 aaagccgcaa accaggtcga cgactggatt gaagaaaaag ttgattatgc attcaatgag 102961 caaagaggat acttaaccag ctgtcctaca aacgtaggta ctggtttaag ggcttcggtc 103021 atgatgcatc tgccggcgct ggttttaact aggcaaataa atcgaattat accggcaatt 103081 aatcaattag gcttagttgt tagaggaatt tatggggaag gcagcgaagc agtagggaat 103141 atctttcaaa tttcaaatca gatcacgctt ggtaagtcag agcaggatat tgtagaggat 103201 cttaacagtg ttgctgctca gttgattgaa caagaacgat ctgcccgaga agcgatttat 103261 caaacttcta aaatcgaact tgaggatcgg gtatatcggt catatggggt cttgtctaat 103321 tgccggatga tagaatcgaa agaaactgca aagtgccttt cagatgttcg gttaggcata 103381 gacttaggca taataaaagg actttcaagc aacatactta acgaacttat gattttgacg 103441 cagccagggt ttttacagca atactcggga ggcgctttgc gaccgaacga aagggacatt 103501 cgaagagcgg ctctcatcag agaacggctt cacttagaaa tgaatgggaa aagacaggag 103561 gatgaatcga tatgatgttt ggaagattta cagaacgagc tcaaaaagta ctggcgctag 103621 cacaggaaga agcacttcgg ttaggtcata ataacattgg cactgagcat attttattag 103681 gactggtaag agaaggagag ggcattgctg ctaaagctct tcaagcgctt ggactcggtt 103741 cagaaaaaat tcagaaagaa gtagaaagtt tgatcgggcg cgggcaggaa atgtctcaaa 103801 cgattcatta tactcctaga gctaaaaaag tcattgagct ttcaatggat gaggcaagaa 103861 aactcggtca ttcttatgtg ggaacagaac atattcttct tggtctgatt cgtgaaggag 103921 aaggtgttgc tgcgagagtt ctgaataatc tcggtgtcag cttaaataaa gcaagacagc 103981 aggtgctcca gcttctagga agtaatgaaa caggatcatc agcggcagga acaaacagca 104041 atgcgaatac gcctacgctt gacagcttgg caagagactt aactgctatt gcgaaggaag 104101 acagccttga ccctgtaatc ggcagaagca aggagatcca gcgtgtcatt gaagtgttaa 104161 gccgcagaac gaaaaacaac cctgttctca ttggggaacc aggtgtaggt aaaacggcta 104221 tcgcagaagg tttggcacag caaattatca ataatgaagt acccgaaatt ttgcgtgata 104281 aacgtgtgat gacattagac atgggaacag ttgttgccgg cacaaaatac cgcggagaat 104341 ttgaggatcg cctgaagaag gtcatggatg aaattcgcca ggcaggaaat atcattctat 104401 tcatcgatga gctccataca ttaatcgggg caggcggagc agaaggtgct attgatgcat 104461 ctaatatttt aaaaccttca cttgctcgtg gcgaactcca atgtattggt gcaacgactc 104521 ttgatgagta ccgtaaatat attgaaaaag atgcagcact ggaacgccgt tttcagccga 104581 ttcaggttga tcagccatct gtagatgaaa gtattcaaat tttacaaggt ctgcgtgaca 104641 gatacgaagc ccaccaccgc gtttctatca ctgatgatgc cattgaagct gcggttaagc 104701 tttctgacag atatatttct gaccgcttcc ttccggataa agcaattgac ttgatcgatg 104761 aagcgggttc aaaggtgaga ctgcgctcat ttacaacgcc tcctaactta aaagagcttg 104821 agcagaagct tgatgaggtt cgtaaagaga aggatgcggc agtgcaaagc caagagtttg 104881 aaaaagctgc ttccttgcgt gatactgaac aacgcctgcg cgagcaagta gaggatacga 104941 agaaatcatg gaaagagaag caagggcagg aaaactcaga ggttactgtg gatgatattg 105001 cgatggttgt atccagctgg accggtgtgc ctgtatctaa aatcgcccaa actgaaactg 105061 ataagcttct caatatggaa aacattcttc actcccgtgt catcggccag gatgaagcag 105121 ttgtagcggt tgcaaaagcc gtcagacgtg caagagcagg attgaaagat cctaaacgcc 105181 caatcggctc attcattttc ttaggcccta caggtgtagg taaaacagaa cttgcacgag 105241 cacttgctga atccattttt ggcgatgaag aatccatgat cagaattgat atgtctgaat 105301 acatggaaaa acattcaact tcaagacttg ttggttcacc tccgggttat gtgggatatg 105361 atgaaggcgg tcaattgaca gagaaagtca gaagaaaacc ttactctgtc gtgcttcttg 105421 atgagatcga gaaagcgcac cctgatgtct tcaatatcct tctgcaagtt cttgaagacg 105481 gacgattgac tgattctaaa ggacgcacag tcgatttccg caataccatt ctgatcatga 105541 catcaaacgt cggagcaagt gagctaaaac gcaataaata tgtcggcttt aacgttcagg 105601 atgaaactca aaatcataaa gacatgaaag ataaagtgat gggtgaatta aaacgagcgt 105661 tcagacctga gttcatcaac cgtattgatg aaatcattgt cttccattca cttgagaaaa 105721 aacatctcac tgagattgtg tcattaatgt ctgatcaatt aacgaaacgc ctgaaagaac 105781 aagatctttc tatcgaattg acagatgctg caaaagcgaa agtcgcggaa gagggcgttg 105841 acctggaata cggtgcccgt ccgttaagaa gagcgatcca aaaacatgtc gaggatcgtt 105901 tatctgaaga actcctcaga ggaaatattc ataaaggaca gcatattgtt cttgatgtag 105961 aagatggcga atttgtcgta aaaacgactg ctaaaacgaa ttaatataga agacggaaat 106021 gaggcataca gcatgtaagt gtatgcctca ctttcatatc aagaaataga acaagggaga 106081 ggtcttacac tatatatggc taaaacaaaa tcgaagttca tctgccaatc ctgcggctac 106141 gagtctccaa aatggatggg gaaatgtccg ggctgtggtg cttggaatac aatggtggaa 106201 gaaatgatta aaaaagcacc ggccaatcgg agagcggctt tttctcattc tgttcaaact 106261 gtacagaaac cttcacctat tacatcaatc gaaacatcag aagaaccccg cgtcaaaacc 106321 cagcttggcg agtttaacag agtactcggc ggaggtgtcg ttaaaggctc cctcgtttta 106381 attggcggtg atcctggtat cggaaagtca acgctattac tgcaggtttc cgctcaatta 106441 tcaggctcat caaacagtgt cctgtatatt tcgggagaag aatctgtaaa gcaaacgaag 106501 ctgcgagcag accgtctcgg cattaataat ccgtcactgc atgttttatc tgaaaccgat 106561 atggagtata tttcgtctgc tatacaagag atgaatccat cgtttgtcgt tgttgactct 106621 attcaaacgg tttaccaaag cgatattaca tctgctccag gcagtgtgtc acaggtcaga 106681 gaatgtaccg ctgagctgat gaaaattgca aaaacaaaag gtattccgat ttttatcgta 106741 gggcacgtga cgaaagaagg gtctattgca ggtccgagac tgttggagca tatggttgac 106801 actgttttat attttgaagg agaacgccac catactttcc gtattttgcg ggctgtaaaa 106861 aaccgtttcg gatctacaaa cgaaatgggc attttcgaaa tgcgggaaga ggggctcact 106921 gaggttttga atccttcgga aattttctta gaagaacgct ctgctggttc cgcaggctcg 106981 agtatcactg cctctatgga gggcactaga ccgattctcg ttgaaattca ggcactcatc 107041 tcgccaacaa gttttggcaa cccaaggcgt atggcaacgg gaatagacca taacagggtt 107101 tctctgttaa tggctgtgtt agaaaaaaga gttggactgc tgctgcaaaa tcaggatgct 107161 tatttgaaag tggctggcgg cgttaagctt gatgaaccgg caattgatct tgcgattgtg 107221 attagtattg catcaagctt tagagacaca cctccaaatc ctgcagattg ttttattgga 107281 gaagtgggat taaccggaga agtccggcgg gtttcaagaa ttgaacagcg tgtgaaagaa 107341 gcggcaaagc ttggttttaa acgcatgatc atacccgcgg caaatctgga tggatggaca 107401 aaaccaaaag ggattgaggt tatcggagta gcaaatgttg cagaagcgct tcgtacttca 107461 ttaggaggat aatagatgga aaaagagaaa aaaggggcga aacacgagtt agacctgtca 107521 tctatattgc agtttgttgc tccgggtaca ccgctcagag cggggatgga aaacgtcttg 107581 agagcaaata caggcggtct gattgttgtt ggatataatg ataaagtaaa agaagtggtg 107641 gacggcggct ttcacataaa cacggctttt tctccggcgc atttatatga gctggctaaa 107701 atggatggag cgatcatttt aagtgattct ggtcaaaaga tcctatacgc gaatactcag 107761 ctgatgccgg atgccacaat ttcttcatca gaaacaggaa tgcggcacag aactgccgaa 107821 agagtagcta agcaaactgg ctgtcttgta atcgccattt ctgaaagaag aaatgtcata 107881 acgttatatc aggaaaacat gaagtataca ctaaaagaca taggatttat tttaaccaag 107941 gcgaaccaag ccattcaaac acttgaaaaa tataagacaa tcctcgataa aacgattaat 108001 gcactgaacg cgttagagtt tgaggaactt gttaccttca gtgatgtctt gtctgtcatg 108061 catcgttatg aaatggtact gagaatcaaa aacgaaatta atatgtatat caaagagctg 108121 gggacagaag ggcatctgat caaactgcaa gtcattgaat tgattacgga tatggaagaa 108181 gaggccgctt tatttattaa ggactatgta aaagaaaaga ttaaagatcc gtttgttctc 108241 ttgaaggagc tgcaggatat gtccagttat gatctgctgg atgattccat tgtgtataag 108301 cttctcggtt accctgcttc tactaatctt gatgattatg tattgccgag aggatacagg 108361 ctgttaaata agataccgcg tcttccgatg ccgattgttg aaaatgttgt agaagcattt 108421 ggagtcctgc caaggattat tgaggcgagt gcagaagaat tagatgaagt agagggaatc 108481 ggtgaagtac gagcccaaaa aatcaaaaaa ggattaaaac gcctgcaaga gaagcattat 108541 ttagacagac aactgtgatt tcggttaaaa ccttatgaat acgggtatat taatgttggt 108601 ttttgtttat tctgatattc gtaggatgca taagactttg tgaaattaaa atgttaaaaa 108661 aggaggtggg ggtatgttaa aacgaatagt tcaggcgttc ttcattattt ttggcggcgt 108721 tgttggtata tttttgatac ctgaattgtt tgtactgtta aatatacagg acataccttt 108781 aataacaaac gcatatacgt ctgcggcaat aggagcaatt atcttttttc tcatcagtat 108841 atggggtaca gaatacgttg tgaactgggt gaagtggata gaggattcat tgttaaaagc 108901 gccggttcca gatttgttat ttggaagtct tggcttagtt tttggactta taattgctta 108961 tcttatcgta aatgttattc ctttagacaa tataccttac cgcatattca gcacaataat 109021 tcctgtattt ttggctttct tcctcggtta tctcggcttc caggtgggct ttaagaaaaa 109081 ggatgaattg atcagcctgt tttccatttc cgccagaatg caaaagaaaa aaggaacagc 109141 tgatgaagaa catgaggttc aagacaagaa gctgaaaatt ttggacacta gtgttattat 109201 tgatgggaga atagcagata tttgtcagac tggtttttta gagggagtta tcgtgattcc 109261 gcagtttgtc cttgaggaat tgcagcatat tgcagactct tcagatgttt taaaacgaaa 109321 cagaggacgc cgcggtcttg atatcctgaa ccgcattcag aaagaattag acattgaagt 109381 tgaaatttac gaaggcgact ttgaagatat tcaggaggtt gacagcaagc tcgtcaaact 109441 tgctaagctg acatccgggg tcgttgtgac gaatgatttt aatttaaata aagtgtgcga 109501 gcttcagaag gtagcagtat taaacattaa tgaccttgcc aatgcggtta agcctgttgt 109561 gcttcctggc gaggaaatga atgttcaggt cattaaggac gggaaagagc ataatcaggg 109621 agttgcctac ttggatgacg gtacgatgat tgtcgttgaa gaaggacgga attatatcgg 109681 caagcatatt gatgtactcg tcacaagtgt gctgcagaca gcagcgggac gaatgatttt 109741 tgcgaagcct aagctgttgg agaaggcgct gtaaagggag aagaaacaat gagttatgat 109801 gtggtgattc ctgcagccgg acagggaaag cggatgaagg cagggagaaa taaactgttc 109861 attgagctga agggagaccc ggtgatcata cacacgttaa gagtgtttga cagccaccgg 109921 cagtgcgata aaatcatttt ggtgattaac gagcaggagc gggagcactt tcagcaattg 109981 ctgtccgatt acccgtttca aacttcaatt gagcttgttg caggcggaga tgagcgacag 110041 cacagtgtgt ataaggggct gaaagccgta aagcaggaaa agattgtcct tgtacatgac 110101 ggtgcccgtc catttataaa acatgaacaa attgacgaac tgatcgcaga ggcggaacag 110161 acaggagcgg ccatccttgc tgttccggta aaagatacga ttaaacgcgt tcaagattta 110221 caagtcagtg agacgattga acgttcaagc ttgtgggctg tccaaacgcc acaagctttt 110281 cgtctttctt tattgatgaa ggctcacgct gaggccgagc gcaagggatt tttagggacg 110341 gatgacgcca gcctcgttga acagatggag ggcggttcgg tccgtgttgt agaaggcagc 110401 tatacaaata ttaagctgac gacgccagac gatttgacgt cagctgaagc tatcatggaa 110461 tcagaaagtg ggaataaaca tgtttagaat tggacaagga tttgatgtgc atcaattagt 110521 ggagggccgt cctctcatta ttggcggaat tgaaatcccg tacgaaaaag ggctgcttgg 110581 ccattctgat gcagacgtat tgttgcatac cgtcgctgac gcctgcctgg gagctgtggg 110641 tgaaggagac ataggcaagc attttcctga cacagatccc gagttcaagg acgcagattc 110701 tttcaaatta cttcagcatg tctggggaat cgtgaaacag aaggggtatg tccttgggaa 110761 cattgattgc accatcatag cgcaaaagcc gaagatgctg ccgtacatag aagatatgag 110821 aaaaagaatt gctgaaggcc ttgaggcaga tgtttctcaa gtaaatgtaa aagcaacaac 110881 gacagaaaag cttggattta caggccgggc ggaaggaata gcggctcagg cgacagtact 110941 gatacaaaaa ggctaacttg ttttgatgcc gggtctattt ggtggtagaa tagattcata 111001 catttttgcc tgaggccata catgacatga aaggaagtat ttgaaaatgg gaaacgaagt 111061 acgcgtccgt tatgcaccga gtccaaccgg acatttgcat attggaaatg ccagaacggc 111121 gctttttaat tatttatttg cccgcaatca aggcggtaag tttatcattc gagttgagga 111181 tactgataaa aagcgcaata ttgagggcgg agaacaaagc cagctgaatt atctgaagtg 111241 gctaggtatt gactgggatg agagtgtgga tgtcggagga gagtacggtc cataccgtca 111301 gtcagagcgt aacgatatct ataaagtgta ctatgaagag cttcttgaaa aagggcttgc 111361 ttataaatgt tactgtacgg aagaagagct tgaaaaagag cgtgaagaac agattgcccg 111421 cggagaaatg cctcgttatt ccggaaaaca cagagacctg actcaggaag aacaggagaa 111481 atttatcgcc gaaggcagaa aaccaagtat tcgtttccgt gtgccggaag gaaaagtcat 111541 cgccttcaac gacatcgtaa aaggcgaaat ttcttttgaa tcagatggca tcggcgactt 111601 cgttattgtg aaaaaggacg gaacgcctac ttataacttc gcggtagcta ttgatgacta 111661 cttaatgaaa atgacacacg tgctgcgcgg tgaggatcat atttctaaca caccgaaaca 111721 gattatgatc tatcaagcat tcgggtggga tattcctcag ttcggacaca tgacgctgat 111781 tgtaaacgaa agccgtaaaa agctcagcaa acgtgatgaa tccattattc aattcatcga 111841 gcagtacaaa gagcttggct acctgccaga agcgctgttc aactttatcg gcttgttagg 111901 ctggtcaccg gttggagaag aagagctttt cacaaaagag cagtttattg aaatttttga 111961 tgtaaatcgt ttatctaaat caccagcttt gtttgatatg cataagctaa aatgggttaa 112021 caaccaatat gtgaagaagc tggatcttga tcaggttgtt gaactgacgc ttccgcattt 112081 gcaaaaagcc ggcaaagttg gcactgagct ttctgctgaa gaacaagaat gggttcgtaa 112141 actgatttcc ctgtatcatg agcaattaag ctacggtgcg gaaattgttg agctgactga 112201 tttgttcttt acggatgaga tcgagtataa tcaagaagcg aaagctgttc tggaagaaga 112261 acaggttcct gaagtgctca gcacattcgc agcgaagctt gaagagcttg aggagttcac 112321 tccggataat atcaaagcat cgatcaaagc agtgcagaaa gaaactggcc ataaagggaa 112381 aaaactgttt atgccgattc gtgttgctgt aacagggcaa actcacggtc cggaactgcc 112441 gcaatcaatt gaattgatcg gtaaagagac tgcaattcag cgtttaaaga atatctaaat 112501 aaatgattgt tgacagggaa gagtataaag ctttaggcca ttacagaaag gatcttcatt 112561 ggctgagaga gatccatgag ccgggtttta gaagtgcgcc cttaagacct ttgaagaacg 112621 ttttttgaaa tcagtattca aaggcggccg ccgccgttac aggctgaagt tgggagagca 112681 gaagtctgct tttcaaacag agtggaaccg cgcggttaaa gcgtctctgt catgtttaca 112741 tgcagagacg ctttttttat tgggtagagg aaatcagata gagaaacggg gggaagcatg 112801 tgttttttag aatgctcaaa gaagacattg atactgtgtt cgatcaagat cccgcagcaa 112861 gaagctattt tgaagtgatt ttaacttatt ccggtttaca tgctatatgg gcgcatcgga 112921 ttgcacatgc tttatataaa cgaaaatttt atttccttgc acgccttata tctcaagtaa 112981 gccgattttt taccgggata gaaatccacc ccggcgctac aatcgggaga agatttttca 113041 tagaccacgg catgggggtt gtcattgggg agacatgtga aatcggcaat aacgtaaccg 113101 tttttcaggg ggttaccctc gggggaacgg gaaaagaaaa gggaaaaagg cacccaacga 113161 ttaaagatga cgcattgata gccacaggtg ctaaagtgct cggttctatt acggtcggtg 113221 aaggctcaaa gattggcgct ggttcagtag tgctgcatga tgttcctgat ttttcaacag 113281 ttgtcggtat ccctggacgg gtcgttgtac aaaatggcaa gaaagtaaga cgcgatttaa 113341 accatcagga tttgcccgat ccagttgctg accgctttaa gtctttggaa cagcagattt 113401 tagagctgaa ggcagaactt gaagacagaa aagaaaggat caatcaaaaa tgacaatcac 113461 actttataat acattgacta gacagaagga aacattcgtt cctcttgaag agggaaaagt 113521 gaaaatgtat gtatgcggac ccacggttta caattacatt catatcggga acgcgcgtcc 113581 ggcaatcgtt tacgatacgg ttcgaaacta tttagagtat aaaggctatg atgtgcagta 113641 tgtctctaac ttcacagacg tagacgataa attaattaaa gcggcaaatg aactcggtga 113701 ggatgtaccc accatttcag agcgttttat taaagcatac tttgaagacg taggtgcgct 113761 cggctgccga aaagccgacc ttcatccgcg agtaatggag aacatggatg ccattatcga 113821 attcgtagat cagctcgtga aaaagggcta cgcatatgaa tcagaaggtg acgtatattt 113881 caaaaccaga gcatttgaag ggtacggaaa gctttctcag caatcaatcg atgaactaag 113941 atcaggtgca cgcatccggg tcggcgagaa aaaagaagat gctcttgatt tcgcactgtg 114001 gaaagcggca aaagaaggag aaatctcttg ggatagccct tgggggaaag ggcgtccggg 114061 ctggcacatt gaatgctcag caatggtgaa aaagtatctc ggtgaccaga ttgatatcca 114121 tgcgggcgga caggatttaa cattccctca ccatgaaaac gaaattgcgc aatctgaggc 114181 gctgacaggc aaaacgtttg cgaagtactg gcttcataat ggttatatca atattgataa 114241 tgaaaaaatg tcaaaatcac taggcaactt tgtgcttgtg catgacatca ttaaacagca 114301 tgatccgcag cttttgagat tctttatgct atctgttcat tatcgccatc cgattaacta 114361 ttcagaagag cttctggaga atacgaaaag cgcgttcagc cgtttaaaaa cagcgtacag 114421 caatcttcag caccgtctga acagcagtac gaatttaacc gaagatgacg atcaatggct 114481 tgaaaaggtt gaagaacacc gcaaagcatt cgaagaagag atggacgatg attttaatac 114541 ggcgaatgcc atttcagtct tgtttgactt agcgaaacac gccaattatt atcttcagaa 114601 agatcatacg gctgatcatg tgattacggc gtttattgag atgtttgacc gcattgtttc 114661 tgtcctcggt ttttcgttgg gtgagcagga acttctcgat caagagattg aagacttaat 114721 cgaaaagcga aatgaagcgc gccggaatcg cgattttgca ttgtcagacc agatccgcga 114781 ccagctgaaa agcatgaata tcattcttga agatacggct caaggcactc gctggaaacg 114841 gggagaataa cagatgcttg aatttgatac gataaaagat tctaagcagc ttaacggtct 114901 tgcgcttgct tatataggtg atgccatttt tgaagtgtat gtcaggcatc acctgcttaa 114961 gcagggcttt accaaaccaa atgatcttca taagaaatca agccggattg tttcagcaaa 115021 gtcacaggct gagatcctat tttttctgca gaatcaatca ttttttacgg aagaagagga 115081 agcggtgctg aaaagaggca gaaatgccaa gtcagggaca acacctaaaa atacagatgt 115141 tcagacgtac cgctacagta cagcatttga agcgcttctg ggctaccttt ttctagagaa 115201 aaaagaggaa cgacttagtc agctcgtagc cgaagctata caattcggga cgtcagggag 115261 gaaaacaaat gagtcagcaa catgattacg tcatagggaa aaatgcagtg atcgagacgt 115321 taaaatctga tcggaagctg tataagctgt ggatggcgga aaacaccgta aagggacaag 115381 cacagcaagt gattgagctt gccaaaaagc agggaatcac gattcaatac gtcccgagaa 115441 aaaaactcga tcaaatggtg acaggacagc atcagggcgt agtggcacag gttgcagcgt 115501 atgaatatgc agaactggac gatttatata aagcagccga agaaaaaaat gaacagcctt 115561 tcttcctcat tctggacgag cttgaagacc ctcataatct tggttccatt atgaggacag 115621 cagatgcggt cggcgctcat ggcatcgtca ttccaaaacg gagagctgtc gggctgacaa 115681 caacagtggc aaaagcttca acaggagcaa ttgagcacat tcctgtagca agagtcacca 115741 atttggcacg gacgttagaa gagatgaaag agcggggaat ctgggttgtc ggaacggatg 115801 cgtccgcgcg tgaggatttc cgtaatatgg acggcaatat gcctttggct ctagtcatcg 115861 gaagtgaagg aaaagggatg ggccgccttg tgaaggaaaa gtgcgatttt ctcattaaac 115921 tcccgatggc cggaaaggta acttcactaa atgcatctgt cgcggctggt cttttgatgt 115981 atgaagtcta ccggaaacga aaccctgtgg gagaataaag acccatggat atcctgttag 116041 tagacgggta caacatgatt ggagcctggc cgcagctgaa ggatttaaaa gcgaacagtt 116101 ttgaagaggc gagagacgta ctgattcaga aaatggcgga atatcaatcg tatacaggaa 116161 acagggttat tgttgttttt gacgcgcatc tcgtaaaagg gcttgagaaa aaacagacca 116221 accatagagt tgaagtaatt tttacaaaag aaaatgagac ggctgatgag cggatagaaa 116281 agctcgctca ggctttgaat aatattgcga ctcaaattca cgttgcgacc tctgactata 116341 ctgagcagtg ggcgattttc ggacaggggg cattgcggaa atcggcccgg gagcttctga 116401 gagaggtaga aacgattgaa aggcgaatag agagacgggt aagaaaaatc acttccgaaa 116461 agccggcggg taaaattgct ttatcggaag aggttttgaa aacgtttgaa aagtggaggc 116521 ggggagactt agattaagtt gacgcttttt tgcccaatac tgtataatat ttctatctac 116581 gtgcgccggg gggatcggag tgaatctaca gaacaacaag ggaaaattca acaaagagca 116641 gttttgccag ttggaggacg agcaggtcat tgaaaaggtt catgttgggg acagtgatgc 116701 gttagattac ttgattacga agtaccgaaa ctttgttcgg gcaaaagcaa gatcctattt 116761 cttaataggg gcggacagag aggatattgt tcaggaaggc atgataggcc tctataagtc 116821 tattcgtgac ttcaaagagg acaagcttac ctcattcaaa gcttttgcag aattatgtat 116881 tacccgccaa attattaccg caataaagac agctactcgc cagaaacaca ttcctttgaa 116941 ttcctacgcc tcattagata aaccgatctt tgatgaagaa tcagaccgaa cgctgctgga 117001 tgtcatttca ggagcgaaaa ccttaaatcc tgaggaaatg atcattaatc aggaagaatt 117061 tgatgatatt gaaatgaaaa tgggagaact attaagtgat ttagagagaa aagtactcgt 117121 cttatatctc gacgggagaa gttaccaaga gatttctgat gaactgaacc gacatgtgaa 117181 atcgatcgac aatgcccttc agcgtgtgaa acgcaagctg gagaagtact tggaaattcg 117241 cgaaatcagt ttgtaatagg aatttatgct atattgacag tatttttctg actatgatat 117301 gttactaaag ataagaacta atgtctattt agaaaaaggt gtaatgacat gagaaaaaag 117361 attacgttag catgcaagac atgcggaaac cgtaattata cgacaatgaa gagctctgca 117421 tcagcggctg agcgattaga agtaaagaaa tactgcagta cttgcaattc acatacagct 117481 catcttgaaa caaaatagtt tttgcgcttt taaattgtgg aggtctttta catgcgtatt 117541 atgaaattct ttaaagatgt tgggaaagaa atgaaaaagg taagctggcc taaaggaaaa 117601 gagttaacgc gttataccat tacggtaatt tcaacagtta tcttttttgt tatctttttt 117661 gccctccttg acacaggaat ttctcaatta attcgtttaa tagttgaata atgatcagca 117721 atacgtgcta taatagatca taatattact tgccaaaacc cgttcagcgg gttttttatt 117781 gtggcttaaa atgaaagtta tcataggctt gccgcctatt ttttgaagcg ttatggtaat 117841 tcactaaaac caaatgcggg gagggaagga ctggacagtc ctgaatagaa tggaaaagaa 117901 ttggtatgtt gttcacacgt actctggtta tgagaataaa gtaaaagcca acttggaaaa 117961 gcgtgttgaa tcaatgggga tgcaggataa aattttccgt gtagtcgtac ccgaagaaga 118021 agaaacggat atcaaaaacg gcaagaaaaa agtcgtgaaa aagaaagtat tccctggtta 118081 tgtgcttgtt gaaattgtaa tgacagacga ctcttggtat gtcgtccgca acacgccggg 118141 cgttactgga ttcgtaggat ctgccgggtc aggttcaaaa ccgacgccgc ttcttccggg 118201 ggaagcagaa accattctga agagaatggg catggatgaa cgaaaaactg atattgactt 118261 tgaactgaaa gagacagtga aagtaataga cggacctttt gctaacttta caggatcaat 118321 tgaagagatt gattatgata aaagcaaggt caaagttttc gttaatatgt ttggccgtga 118381 aacgccggtt gagctggaat ttacccaaat cgataaattg taatgtgaaa aaacttgaaa 118441 ttgctatata taaatgataa tatagcaaag gtacgtcttg gacttatcca aggcaactag 118501 catgatattt cgtcattcat ataaagaatg aaaccttgag tgggagggtt taccctatta 118561 ccacatcacg gacttaagga ggtgtgtctc gtggctaaaa aagtagttaa agttgtaaaa 118621 ttgcaaattc ctgctggaaa agctaaccca gcaccaccag ttggacctgc acttggtcaa 118681 gccggtgtta acatcatggg attctgtaag gagtttaacg ctcgtacagc tgaccaagct 118741 ggtttaatca ttcctgttga aatttcggtt tacgaagacc gttcatttac atttattaca 118801 aaaactccac ctgctgcagt attgcttaaa aaagcagctg gaattgagtc tggttctggt 118861 gaaccaaacc gtaataaagt ggcaaccgtt aagcgcgata aagtacgcga aatcgctgaa 118921 acgaaaatgc ctgacttaaa cgcagcagac gttgaagcgg caatgcgcat ggttgaaggt 118981 actgcccgca gtatgggtat tgtaatcgag gattaatttg tttcttgtcg ggttgcgagt 119041 tttaacaagt tcgcaaccct tattcgtggg aggttattcc gctataacca cataaggagg 119101 aaattttaaa atggctaaaa aaggtaaaaa gtacgttgaa gctgctaagc ttgtagaccg 119161 ttctaaagct tacgacgtct ctgaagcagt agctctcgtt aaaaaaacaa acacagctaa 119221 attcgacgct acagttgaag tggctttccg tttaggggtt gaccctcgta aaaacgacca 119281 gcaaatccgt ggagcagttg tgcttccaaa cggaactggt aaaactcagc gcgttctcgt 119341 tttcgcaaaa ggcgaaaaag cgaaagaagc tgaagctgct ggtgcagatt tcgtaggcga 119401 tactgactac atcaacaaaa ttcaacaagg ctggttcgat ttcgatgtta tcgtagctac 119461 acctgacatg atgggtgaag ttggtaaaat cggtcgtgta cttggaccaa aaggtttaat 119521 gccgaaccct aaaactggta cagttacttt cgaagttgaa aaagctatcg gcgaaatcaa 119581 agctggtaaa gttgaatacc gcgttgataa agctggaaac attcatgttc ctatcggtaa 119641 agtttctttc gaggatgaaa aacttgttga gaacttcaca acaatgtacg atacaatcct 119701 taaagctaaa cctgctgcag ctaaaggcgt ttacgtgaaa aacgttgctg taacttctac 119761 tatgggacct ggtgtcaaag tagactcttc aacttttaac gtaaaataat attgacatga 119821 catcaacatt ctgatattat tcaaaatgtt gtaaaataga atatcattta taccgtagac 119881 agtaggggcc taaccgctta attatcctac cgaggtgtat attatcacag ctattacgtt 119941 acgtatgctt gtatatacag cctccatgtc tcatggaggc tttttatatg gaatccgtcg 120001 tctcagtcgt gatcacctaa cggtataagt gttacacaag aatctacagg aggtgtaacc 120061 atgagcagcg caattgaaac aaaaaaagtt gttgttgaag aaattgcttc taaactgaaa 120121 gaaagtaaat caacgatcat cgttgactat cgcggactta acgtttctga agtaactgaa 120181 cttcgtaaac agcttcgcga agctaacgtt gagttcaaag tttacaaaaa tacgatgact 120241 cgccgtgcgg ttgaacaagc tgagcttaat ggtttgaatg atttcttaac tggaccgaac 120301 gcgatcgcat tcagcactga agatgttgtc gctccggcta aagttcttaa tgacttcgct 120361 aaaaatcacg aagctcttga aatcaaagct ggcgttatcg aaggtaaagt ttctactgtt 120421 gaagaagtga aagctcttgc tgaacttcca tcacgcgaag gcttgctttc tatgttgctt 120481 agcgtacttc aagctccagt tcgcaacctt gctcttgctg caaaagctgt ggcagaacaa 120541 aaggaagaac aaggcgctta atctaatcag tttttcataa attaaaacaa aatggaggaa 120601 ttacaaatgg ctttaaatat cgaagaaatc attgcttccg ttaaagaagc aactgtactt 120661 gaattgaacg acctagtaaa agcaatcgaa gaagaatttg gcgtaactgc tgctgctcct 120721 gtagctgtag ctggcggagc tgctgctggc ggagctgctg aagagcaaag cgaattcgat 120781 cttatccttg ctggtgcagg atctcaaaaa atcaaagtta tcaaagttgt acgtgaaatc 120841 actggtcttg gcttgaaaga agctaaagag cttgttgaca acactccaaa accacttaaa 120901 gaaggtattg ctaaagaaga agctgaagag cttaaagcta aacttgaaga agttggcgct 120961 tctgtagaag ttaagtaatc ttcacttacc tgtaggggaa gctcgctttt atgaggcgag 121021 ctttttcttt gccattcttt aagccatgaa aaaaggaggt tctaataatg agtgagcact 121081 attattcaga aaaaccttca gtaaaaagca acaagcaaac ctggtctttt aggcttcgga 121141 ataaagattt cacgtttacc agcgacagcg gggttttttc taaaaaagaa gttgatttcg 121201 gctcccgcct gctgattgat tcttttgaag agcctgaggt tgagggcggc attttagatg 121261 taggctgcgg atacggcccg attggtttat cgctcgccag cgactttaaa gaccggacca 121321 tccacatgat tgacgttaat gagagagccg tagaactatc aaatgaaaat gcggaacaga 121381 acggaataac aaacgttaag atttatcaaa gcgatttgtt ttcaaacgtt gattctgctc 121441 aaacatttgc ttctattctt acaaatcccc caatccgagc cggaaaaaaa gttgtccatg 121501 ctatctttga gaaaagcgct gaacacttaa aagcttcagg tgaattgtgg atcgtcatac 121561 agaaaaagca aggcgcgcct tctgccattg aaaagctcga ggaactgttc gatgaagttt 121621 ccgtcgttca aaaaaagaaa ggctattata tcataaaagc aaaaaaagtt tgactcggta 121681 ttttaactat gttaatattg taaaatgcca atgtatatat tttgcttgat atgatgaatt 121741 gtcaatatct atgtataaat tatacaagta tggaaatgct aataaaatcg gtatttgttt 121801 ttggatgtgg ttttcttaat tagaaaccct tttttctttt gtcttgtaaa agtattttct 121861 ttctttggaa gaaatgctta ttacacatat aatacgcatg atttgagggg tgaatcagtt 121921 gacaggtcaa ctagttcagt atggacgaca ccgccagcgc agaagctatg ctcgcattag 121981 cgaagtgtta gaattaccaa atctcattga aattcaaacc tcttcttatc agtggtttct 122041 tgatgagggt cttagagaga tgtttcaaga catatcacca attgaggatt tcactggtaa 122101 cctctctctt gagttcattg attatagttt aggtgagcct aaatatcctg tagaggaatc 122161 aaaagaacgt gatgtgactt actcagctcc gctaagagtg aaggttcgtt taattaacaa 122221 agaaactgga gaggtaaaag accaagatgt cttcatgggt gatttcccta ttatgacaga 122281 tacaggtact tttatcatta acggtgcgga acgtgttatc gtttcccagc ttgttcggtc 122341 tccaagtgta tatttcagtg gtaaagtaga caaaaacggt aaaaaaggtt ttaccgcaac 122401 tgtcattcca aaccgtggcg catggttaga atacgaaact gatgcgaaag atgttgttta 122461 tgtccgcatt gatcgcacac gtaagttgcc ggttacggtt cttttgcgtg ctctcggctt 122521 cggctccgat caagagattc ttgatctcat aggagaaaac gaatacctgc gaaatacgct 122581 tgataaagat aacacagaaa acagcgacaa agcgttgctg gaaatttacg agcgtctccg 122641 tcctggagag ccgcctacag tagaaaatgc gaaaagcttg cttgattctc gtttctttga 122701 tccgaaacga tacgatcttg ccaatgtagg acgctataaa attaataaaa aacttcatat 122761 taagaatcgc ctcttcaatc agagacttgc tgaaacgctt gttgatcctg aaacaggaga 122821 aatccttgct gaaaaaggcc agattcttga tagaagaacg cttgataaag tactgccata 122881 cttagaaaac ggaatcggtt ttagaaagct gtatccgaat ggcggcgttg ttgaagatga 122941 agtgactctt caatcaatta aaatctttgc tccgactgat caagaaggag aacaggttat 123001 caatgtaatc ggcaatgctt acatcgaaga agagattaaa aacatcacgc ctgctgatat 123061 tatttcttca atcagctact tcttcaacct gctgcacgga gtaggcgaca cagatgatat 123121 cgatcatctt ggaaaccgcc gtttacgttc tgtaggcgag cttctccaga accaattccg 123181 tatcggttta agccgtatgg agcgtgtggt tcgtgagaga atgtcaattc aagatacgaa 123241 tacaattacg cctcagcagc tgatcaatat tcgtcctgtt attgcgtcca ttaaagagtt 123301 ctttggaagc tcacagcttt ctcaattcat ggatcagacg aacccgcttg ctgaattaac 123361 gcacaagcgt cgtctgtcag cattaggacc gggcggattg acacgtgagc gtgccggaat 123421 ggaagtgcgt gacgttcact actcccacta tggccgtatg tgtccgattg aaacgcctga 123481 gggcccgaac atcggtttga tcaactcact atcatcttat gcaaaagtaa accgttttgg 123541 ctttattgaa acgccatatc gccgcgttga ccctgaaaca gggaaggtaa cgggcagaat 123601 cgattactta actgctgatg aagaggataa ctatgttgtc gctcaagcga atgctcgtct 123661 tgatgacgaa ggcgccttta ttgatgacag catcgtagct cgtttccgcg gggagaacac 123721 cgttgtttcc agaaatcgtg tagactacat ggatgtatcg cctaagcagg ttgtatctgc 123781 tgcgacagca tgtatcccgt tcttagaaaa cgatgactcc aaccgtgccc tcatgggagc 123841 gaacatgcag cgtcaggctg tgcctttgat gcagccggaa gcgccatttg ttggaactgg 123901 tatggaatac gtatcaggaa aagactctgg tgccgctgtt atttgtaaac accctggtat 123961 cgttgaacgc gtagaagcca aaaacgtttg ggttcgccgt tatgaagaag tagacggtca 124021 aaaagtaaaa ggaaacctgg ataaatacag cctgctgaaa tttgtccgct ctaaccaagg 124081 tacgtgctac aaccagcgtc cgatcgtaag tgtcggcgat gaagtggtaa aaggagaaat 124141 ccttgctgac ggtccttcta tggagcttgg tgaacttgca cttggccgta acgtaatggt 124201 cggcttcatg acgtgggatg gctacaacta tgaggatgcc atcatcatga gtgaacgcct 124261 agtgaaggat gatgtttata catctatcca cattgaagaa tacgaatcag aagcacgtga 124321 tacgaaactt ggacctgaag aaatcactcg cgatattcca aacgtcggtg aagatgcgct 124381 tcgcaatctt gatgaccgcg gaatcatccg tattggggca gaagtaaaag acggagatct 124441 tcttgttggt aaagtaacgc ctaaaggcgt aactgaactg actgccgaag aacgccttct 124501 tcacgccatc tttggcgaga aagcccgcga ggttcgtgat acttctcttc gtgtgcctca 124561 tggcggcggc ggaattatcc atgacgttaa agtcttcaac cgtgaagacg gagacgaact 124621 tcctccaggt gttaaccagt tagtacgcgt atatatcgtt cagaaacgta agatttctga 124681 aggggataaa atggccggtc gtcacggtaa caaaggtgtt atctctaaga ttcttcctga 124741 agaggatatg ccttaccttc ctgacggcac accaattgat atcatgctta acccgctggg 124801 cgtaccatca cgtatgaaca tcgggcaggt attggaactt cacatgggta tggccgctcg 124861 ttaccttggc attcacattg catctcctgt atttgacgga gcgcgagaag aggatgtctg 124921 ggaaacactt gaagaagccg gcatgtctcg tgacgccaaa acagtgcttt acgacggacg 124981 tactggagag ccgtttgata accgtgtatc tgtcggtatc atgtacatga tcaaactggc 125041 tcacatggtt gacgataaac ttcatgcacg ctctacaggc ccttactcac ttgttacgca 125101 gcagcctctt ggcggtaaag cgcaatttgg cggacagcgt tttggtgaga tggaggtttg 125161 ggcacttgaa gcttacggtg cggcttacac tcttcaagaa attctgactg ttaagtctga 125221 tgacgtggtt ggacgtgtga aaacatacga agccatcgtt aaaggcgaca atgttcctga 125281 accaggtgtt ccggaatcat tcaaagtatt aatcaaagaa cttcaaagct taggtatgga 125341 tgtcaaaatc ctttctggtg atgaagaaga aatagaaatg agagatttag aagacgaaga 125401 agatgcgaaa caagctgacg gcctggcatt atcaggtgat gaagagccgg aagaaacagc 125461 atctgcagac gttgaacgcg atgtagtaac aaaagaataa tctctagtta taaaggcaag 125521 tgacatcggt taatccgaag ataaaaaggg aggtaggccc cttgctagat gtgaacaatt 125581 ttgagtatat gaacatcggt cttgcttcac cagataaaat ccgttcatgg tcttttggtg 125641 aagtgaaaaa gcctgaaacg ataaactatc gtacgttaaa acctgaaaag gacggtctat 125701 tctgcgaacg cattttcgga ccgactaagg actgggaatg tcattgcggg aagtacaagc 125761 gagttcgtta taaaggcgta gtttgtgacc gctgcggagt cgaagtaaca cgggctaaag 125821 tccgtcgtga gagaatgggg cacattgaac tggctgcccc agtttcccac atttggtatt 125881 tcaaaggtat tccaagccgt atgggtcttg tgctggatat gtcacctcgt gctttagaag 125941 aagtcattta ctttgcttct tacgttgtaa ctgatccggc gaatacaccg cttgaaaaga 126001 aacagcttct gtctgagaaa gaataccgtg cttatcttga taaatacggt aataaattcc 126061 aagcatctat gggtgctgaa gcaattcata aacttcttca agatatcgat cttgtaaaag 126121 aagttgatat gttaaaagaa gagctgaaaa cttcacaagg acaacgccgt actcgtgcga 126181 tcaaacgtct tgaagtttta gaagccttcc gtaactcagg aaacaagcct tcttggatga 126241 tccttgatgt gcttcctgtt attcctccgg agcttagacc gatggttcag ctagatggcg 126301 gacgttttgc gacttctgat ttgaatgacc tttatcgtcg tgtcatcaac cgtaacaatc 126361 gtttgaaacg ccttttggac cttggtgcgc ctagcatcat cgttcaaaac gaaaagcgta 126421 tgcttcaaga ggctgtcgat gccctaattg acaacggccg ccgcggacgc cctgtaacag 126481 gtcctggaaa cagaccgtta aaatctcttt ctcacatgct gaaagggaag caaggccgtt 126541 tccgtcaaaa ccttcttggt aaacgtgtcg attactccgg acgttctgta atcgttgttg 126601 gtcctcattt gaaaatgtac caatgcggat taccgaagga aatggcactt gaacttttca 126661 aacctttcgt tatgaaagaa cttgttgaaa aaggtcttgc tcacaacatt aagagtgcga 126721 aacgcaaaat tgagcgcgta cagcctgaag tttgggatgt actagaatca gttattaagg 126781 agcatccggt actgctgaac cgtgccccta cacttcacag attaggtatc caggcgtttg 126841 aaccaacgct tgttgaagga cgcgcaatcc gtcttcaccc gctcgtatgt acagcttaca 126901 acgctgactt tgacggtgac caaatggcgg ttcacgtacc attatctgct gaagcacaag 126961 ctgaagcacg catcttgatg cttgctgctc aaaacatctt gaaccctaaa gatggtaaac 127021 cggttgtaac accgtctcag gatatggtac taggtaacta ttacctgaca cttgagcgtg 127081 ccggtgctgt cggtgaaggt atggtcttca agaatacaga cgaagcgctt cttgcttatc 127141 aaaacggata tgttcacctt catacgagag tagctgttgc agctaactca cttaagaatg 127201 tgacatttac cgaagaacag cgctcaaaat tgttaattac aactgtcggt aagcttgtct 127261 tcaatgaaat tcttccggaa tcattccctt acatgaatga accaacgaag agcaacattg 127321 aagagaaaac acctgaccgt ttcttcttag aaaaaggtgc tgatgttaaa gctgttatcg 127381 cacagcagcc aatcaatgcg ccgtttaaaa aaggcattct gggtaaaatc atcgcggaaa 127441 tctttaaacg attccatatt acggaaacgt ctaaaatgct tgaccgcatg aaaaacctag 127501 gtttcaaata ttcaactaaa gctggtatta cagttggggt ttctgacatc gtcgtactcg 127561 atgataaaca agaaattctt gaggaagcgc aaagcaaagt tgacaacgtt atgaagcaat 127621 tccgccgcgg tcttatcact gaagaagaac gctatgagag agtcatctct atctggagtg 127681 ctgcaaaaga cgttatccaa ggcaaactga tgaaatcact tgatgaactc aacccgatct 127741 acatgatgag tgactctggt gcccgtggta acgcatctaa ctttacgcag cttgccggaa 127801 tgcgcggcct gatggccaac ccggctggac gtatcattga gttgccgatc aaatcaagtt 127861 tccgtgaagg tctgacagta ttggagtact ttatctccac acacggtgcg cgtaaaggtc 127921 ttgccgatac cgctcttaaa actgctgact caggttacct tacacgccgt ctcgttgacg 127981 ttgctcagga tgttatcatc cgtgaaactg attgcggaac tgaccgaggc attcttgcta 128041 agcctcttaa agaaggaact gaaacaattg agcgcttaga agaacgctta atcggacgtt 128101 ttgcaagaaa acaagtgaag caccctgaaa caggtgaagt gcttgtgaat gaaaacgaac 128161 tgatcgatga agataaagca ctggagattg tcgaagccgg cattgaagaa gtgtggatcc 128221 gttctgcctt cacatgtaat acgcctcatg gtgtatgtaa acgatgctat ggccgaaatc 128281 ttgcaactgg ctccgatgtt gaagtcggtg aagctgtcgg aatcattgct gcccaatcaa 128341 tcggtgagcc tggtacacag ttaacaatgc gtacattcca tacaggcggg gttgccggag 128401 acgatatcac acagggtctt ccgcgtatcc aagagctttt cgaagcgcgt aatccgaaag 128461 gtcaggcaac aattacagaa atcgacggta cagtcgttga gatcaatgaa gttcgtgata 128521 agcaacagga aattgtggtt caaggcgcag tggaaacacg ttcttatacg gcaccttaca 128581 actcccgcct gaaagtagcg gaaggagata aaattactcg aggccaagta ctgacagaag 128641 gttcaatcga tccgaaagaa cttcttaaag tgactgacct gacgactgtt caagagtatc 128701 ttctccatga ggttcaaaag gtttaccgta tgcagggtgt tgaaatcggt gataaacacg 128761 tagaagtaat ggttcgccag atgcttcgca aagtacgcgt gattgatgcc ggtgacactg 128821 atgtgcttcc aggtacattg cttgatattc accaatttac tgaagcgaac aaaaaggtat 128881 tgcttgaagg caaccgacca gctacaggcc gtcctgtctt actcggtatt acaaaagcat 128941 ctcttgaaac tgattcattc ttatctgctg cttccttcca ggaaacaaca cgtgtcctta 129001 cagatgcagc gatcaaaggt aagcgtgacg agcttctcgg cttgaaagag aatgttatca 129061 tcggtaagct tgttccagca ggtacaggaa tgatgaaata ccgtaaagta aaaccagtat 129121 caaatgttca gccgactgac gatatggtcc cggttgaata actgatttaa ctctgctgaa 129181 agactgcaaa aacagtcttt cagcagatat atttatgaaa aagtcactct atgagaagaa 129241 cgaatctaaa aaatgtcata ccttgttgac attcgtctcc tagaatgata atataaccaa 129301 ggtgctcgaa ataaacctgt tactttggag gatatgttta tgtcttatga taaagtatca 129361 caggccaaat caattattat tggtacgaag caaacagtga aagctctaaa gcgaggttca 129421 gtaaaggaag tagtcgttgc aaaagacgca gatccgatac tcacgtcaag tgttgtttca 129481 cttgctgaag atcaaggtat ctctgtctca atggttgaat ccatgaaaaa gctcggcaaa 129541 gcctgcggaa ttgaggtagg agcagccgct gttgccatta ttttataacg tacttttgtt 129601 tttgcgtaag attccatctt gtgtaaagac attgtttttt gccttttgat gaaccacctg 129661 ggtatgtggg ttataaaacg taatgaaggg aggaaaaatt catgcctaca attaatcagc 129721 taattcgcaa aggacgcgtg agtaaagtag aaaactcaaa gtctcctgca cttaacaaag 129781 gatacaacag ctttaaaaaa gagcacacta acgtatcttc tccacaaaaa cgcggggtat 129841 gtactcgtgt tggtacaatg acaccgaaaa aaccgaactc agcacttcgt aaatatgctc 129901 gtgttcgttt gactaacgga atcgaggtta ctgcttacat tcctggtatc ggtcacaacc 129961 tgcaagagca cagtgttgta cttatccgcg gcggacgtgt aaaagactta ccaggggtac 130021 gttaccacat cgttcgtggt gcgcttgata ctgctggagt tgaaaaccgt gcacaaggcc 130081 gttctaaata cggtacgaaa aaacctaaag caaaataata tacgaaaata cgcataattg 130141 atgaagggag gatattcaga tgccacgtaa aggtcctgta gcaaaaagag atgttttacc 130201 tgatccgatt tacaactcta agcttgtatc tcgtttaatc aacaaaatga tgatcgatgg 130261 taaaaaaggt aagtctcaaa cgatcctata caagtcattc gatatcatta aagaacgtac 130321 tggcaatgat gcaatggagg ttttcgaaca agcattgaaa aacatcatgc ctgtacttga 130381 agtaaaagca cgccgtgtag gtggtgcgaa ctaccaagtt cctgtagaag ttcgtcctga 130441 acgtcgtacg actcttggac ttcgctggtt agttaactac gctcgtcttc gtggagaaaa 130501 aacgatggaa gagcgtttag ctaacgaaat ccttgacgca gctaacaaca ctggtgctgc 130561 tgttaagaaa cgtgaagaca ctcataagat ggctgaagca aacaaagcat ttgctcacta 130621 tcgctggtag gatttataga ttaacaaaac acaatttcct aataaggaag gagaaattac 130681 ccaatggcaa gagagttctc cttagaaaaa actcgtaata tcggtatcat ggctcacatc 130741 gatgccggta aaacgactac tacagaacgt atcttgttct atactggtcg tatccacaaa 130801 attggtgaaa ctcatgaagg agcttcacaa atggactgga tggagcagga acaagaacgt 130861 ggtatcacaa tcacttccgc tgcgactact gcacagtgga aaggataccg cgtaaacatc 130921 atcgatactc caggacacgt agacttcaca gttgaagttg aacgttctct tcgtgtactt 130981 gatggtgctg ttgctgtact tgacgcgcaa tcaggcgttg agcctcaaac agaaactgtt 131041 tggcgtcagg caacaactta tggagtaccg cgtatcgttt ttgttaacaa aatggacaaa 131101 atcggtgcag acttccttta ctctgtagga actttaagag accgtcttca agcaaacgct 131161 catgcaattc aattgccgat cggtgctgaa gataacttcg aaggtatcat tgaccttgta 131221 gaaaacgttg cgtatttcta cgaagatgac ctcggaactc gttctgatgc aaaagaaatc 131281 cctgaagagt acaaagagca agctgaagag cttcgcaaca gccttattga agctgtatgt 131341 gagcttgatg aagagcttat ggataagtac cttgagggtg aagaaatcac aattgacgag 131401 ttaaaagcag gaattcgtaa aggtacatta aatgttgaat tctaccctgt tcttgttggt 131461 tctgccttca aaaacaaagg tgttcaacta gtacttgatg ctgttcttga ctaccttcct 131521 gcaccaactg acgttgctgc aatcaaaggt acacgtcctg atacaaatga agagattgag 131581 cgtcattctt ctgacgaaga gccattctct gcattagcat ttaaagttat gactgaccct 131641 tacgttggta agttgacgtt cttccgtgtg tactctggaa cacttgattc tggttcatac 131701 gtgaaaaact ctactaaagg caaacgtgag cgtgttggac gtattcttca aatgcacgct 131761 aacagccgtg aagaaatctc tactgtatac gcaggggata tcgcagctgc tgtaggtcta 131821 aaagatacaa ctactggaga tactctatgt gatgagaagg atcttgttat ccttgagtca 131881 atggaattcc cagaaccagt tatcgacgtt gctattgagc ctaaatcaaa agctgaccaa 131941 gataaaatgg gtatcgcttt agcgaaactt gctgaagaag atcctacatt ccgtactcaa 132001 acaaacccag aaactggcca aacgatcatc tctggtatgg gtgaacttca ccttgatatc 132061 attgttgacc gtatgaaacg cgaatttaaa gtagaagcca atgttggtgc tcctcaagtt 132121 gcgtaccgtg aaacattccg taccggtgca aaagttgaag gtaaattcgt acgtcagtct 132181 ggtggacgcg gtcagttcgg acacgtttgg atcgaattcg aaccaaacga agaaggcgct 132241 ggctttgaat ttgaaaatgc gattgtcggt ggggtcgttc ctcgtgaata catcccagct 132301 gttcaagcag gtctggaaga tgcactcgaa aatggtgtac tagcaggctt cccgcttatc 132361 gacattaaag ctaaactttt cgacggttct taccatgatg ttgactcaaa cgaaatggca 132421 tttaaagtcg ctgcttctat ggcattgaaa aatgcagtca gcaaatgtaa cccagttctt 132481 cttgaaccaa tcatgaaagt ggaagtggtt attccagaag aatatatggg agatatcatg 132541 ggtgatatca cttcacgtcg cggacgcgta gaaggtatgg aagcacgcgg taacgctcaa 132601 gttgttcgtg ctatggttcc tcttgctgaa atgttcggtt acgctactgc acttcgttct 132661 aatacgcaag gtcgcggtac gttcactatg cacatggatc actacgaaga agtgccgaag 132721 agcgtcgcag aagaaattat caaaaaaaat aaaggcgaat aattgatttt gccgcttaac 132781 tcaagtataa ctactattgt aagatgagga agtgaaagct ttctttcact tcctatcact 132841 ctatacatta ctaattaaaa gctcttaagg aggattttag aatggctaaa gaaaaattcg 132901 accgttccaa atcacatgcc aatattggta caattggaca cgttgaccat ggtaaaacaa 132961 ctttaactgc tgctatcaca acagtacttc ataagaaatc tggtaaaggt acagctatgg 133021 cgtacgatca aattgatggt gctccagaag aacgcgagcg cggtatcaca atctctactg 133081 cacacgttga gtacgaaact gaaactcgtc actatgcaca cgttgactgc ccaggacacg 133141 ctgactatgt taaaaacatg atcactggtg ctgcgcaaat ggacggagct atccttgtag 133201 tatctgctgc tgatggccca atgccacaaa ctcgtgagca catccttctt tctaaaaacg 133261 ttggtgtacc atacatcgtt gtattcttaa acaaatgcga catggtagac gacgaagagc 133321 ttcttgaact agttgaaatg gaagttcgcg atcttcttag cgaatacgac ttccctggtg 133381 atgatgtacc agttgttaaa ggttctgctc ttaaagctct tgaaggagac gctgagtggg 133441 aagctaaaat cttcgaactt atggatgcgg ttgatgagta catcccaact ccagaacgcg 133501 acactgaaaa accattcatg atgccagttg aggacgtatt ctcaatcact ggtcgtggta 133561 cagttgctac tggccgtgta gaacgcggac aagttaaagt cggtgacgaa gttgaaatca 133621 tcggtcttca agaagagaac aagaaaacaa ctgttacagg tgttgaaatg ttccgtaagc 133681 ttcttgatta cgctgaagct ggtgacaaca ttggtgccct tcttcgcggt gtatctcgtg 133741 aagaaatcca acgtggtcaa gtacttgcta aaccaggtac aatcactcca cacagcaaat 133801 tcaaagctga agtttacgtt ctttctaaag aagagggtgg acgtcatact ccattcttct 133861 ctaactaccg tcctcagttc tacttccgta caactgacgt aactggtatc atccatcttc 133921 cagaaggcgt agaaatggtt atgcctggag ataacactga aatgaacgtt gaacttattt 133981 ctacaatcgc tatcgaagaa ggaactcgtt tctctattcg tgaaggcgga cgtactgttg 134041 gttcaggcgt tgtttctaca atcactgagt aatagtatgg ttttaaacga gacccctgtg 134101 ggtctcgttt tttgtttgct tatctttttc ttgtataata ggatctatca tattcgaggg 134161 gttaatattt atgattcctg aaaagaaatc aatcgcaatc atgaaagaac taagcattgg 134221 aaatacaaag caaatgctga tgattaatgg agttgacgtg aaaaatccat tgctgctttt 134281 tttacatggc gggccgggaa cgccgcaaat cggatatgtt agacattatc aaaaagagct 134341 ggaacagtat tttacagtag ttcattggga tcagagagga tcggggcttt cttattctaa 134401 gcgaatttcg catcactcta tgacaataaa tcacttcatt aaagatacaa tccaagtcac 134461 tcaatggctt ttagctcatt tttcaaaatc aaaactttac ctagccggtc attcttgggg 134521 atcaatactg gcgcttcatg tgctgcagca gcgtcctgat ttattttaca cgtattatgg 134581 aatcagccag gttgttaacc cgcaagatga agaatcaact gcttatcaac atattcgtga 134641 aatttccgaa tcaaaaaaag ccagcatatt atctttcctt acacgtttca ttggtgctcc 134701 gccttggaag caggatatcc agcaccttat ctatcggttt tgtgttgagc taaccagggg 134761 aggattcact caccgtcatc gtcaatctct cgctgtatta tttcaaatgc ttactggcaa 134821 tgagtatgga gtgcggaaca tgcacagctt ccttaatgga ttgcgcttca gtaaaaaaca 134881 tttaactgat gagttgtacc ggtttaatgc ttttacatca gttccttcta ttaaagtacc 134941 gtgtgttttc atttcaggga aacatgactt aattgttcct gcagaaatat cgaaacagta 135001 ttatcaagaa cttgaggcac ctgaaaagcg ctggtttcaa tttgagaatt cagctcacac 135061 cccgcatatt gaggagccat cattattcgc gaacacatta agtcggcatg cacgacacca 135121 tttatgatag atccttgata aataagaaaa acccctgtat aataaaaaaa gtgtgcaaat 135181 catgcatatt ttaaataagt cttgcaacat gcgcctattt tctgtataat ggtgtatgtt 135241 ggtctttgac tgcgatgaag tgagaggttg ctgacacacc cggccgcttt gccatggcaa 135301 ggtgttcagg tttttctcac ggagaactgt ctaacgtgat gtaggcgaaa aggagggaaa 135361 ataatggcaa aacaaaaaat tcgtattcgt ttgaaagcat atgatcatag aatccttgat 135421 caatctgcag agaagattgt tgaaacggca aaacgttctg gtgccagcgt atctggtccg 135481 attccgttgc caactgaaaa atcagtttac acaatccttc gtgcggtgca caaatacaaa 135541 gattctcgtg agcaatttga aatgcgtaca cataaacgtt taatcgacat tgtgaaccca 135601 acaccacaaa ctgttgatgc tcttatgcga ttagacttac catctggtgt cgatatcgaa 135661 attaaacttt aattctaaaa tatagaatga tcttaatagg aggtgtgacg aatgaccaaa 135721 ggaatcttag gaagaaaaat tggtatgacg caagtattcg ctgagaatgg tgatcttatt 135781 ccggtaactg ttatcgaggc tgctccaaac gttgttcttc aaaagaaaac agctgaaaac 135841 gacggttacg aagcaatcca gcttggtttt gacgacaagc gtgaaaagct ttctaacaaa 135901 cctgaaaaag ggcacgttgc aaaagcggaa actgctccta agcgcttcgt taaagaatta 135961 cgcggagtgg aaatggatgc gtatgaagtt ggtcaggaag tcaaggttga aattttctct 136021 gctggagaaa tcgtagatgt aacaggagta tctaaaggta aaggtttcca aggtgcgatc 136081 aagcgccacg gacaatctcg cggacctatg tctcacggtt cacgctacca ccgtcgtcct 136141 ggttcaatgg gacctgtaga tcctaaccgt gtattcaaag gtaaattatt acctggacgt 136201 atgggcggag agcaaatcac tgttcaaaac cttgaaatcg taaaagttga tgcagaacgc 136261 aatcttcttt tgatcaaagg taacgtacct ggtgcgaaga aatctttaat cactgttaaa 136321 agtgctgtta aatctaaata attctcttag gaaaggagga aattgattat gccaaaagta 136381 gcattataca accaaaacgg ttctactgct ggtgacatcg aattaaacgc ttctgtattt 136441 ggtatcgaac caaatgagag tgttgtattc gacgctattc ttatgcaaag agcttcctta 136501 cgtcaaggaa ctcacaaagt aaaaaatcgt tctgaagtac gcggcggagg tcgtaaacca 136561 tggcgtcaaa aaggtactgg acgtgcccgt caaggttcaa tccgttcacc gcaatggcgc 136621 ggaggtggtg tcgtattcgg cccaacacca cgcagctatt cttataaatt acctaaaaaa 136681 gttcgccgct tggcaatcaa atcagtattg tcttctaaag tgatcgacaa caacatcatc 136741 gttcttgaag atcttactct tgatacggct aaaacaaaag aaatggcagc tatccttaaa 136801 ggattatctg ttgagaaaaa agctttaatc gtaactgcgg atgcaaacga agcagtagca 136861 ttatctgctc gtaacattcc tggagttact gttgttgaag ctaacggaat caacgtttta 136921 gacgttgtca accacgagaa gcttctgatt acaaaagcag cggttgaaaa agtagaggag 136981 gtgcttgcat aatgaaagat cctcgtgatg ttctaaagcg ccccgtcatt actgaacgtt 137041 ctgccgattt aatgactgaa aaaaaatata cttttgaagt tgatgtaaga gctaacaaaa 137101 cagaagtgaa agacgcggtt gaaagcatct ttggagtgaa agttgacaaa gtcaacatca 137161 tgaactacaa aggcaaatca aaacgtgttg gacgctacac tggtatgact agccgtcgca 137221 gaaaagcgat cgtaaaactt actgcagaca gcaaagaaat cgaaattttt gaagcttaat 137281 tatctgtaaa aagaaggagg gaaattcaaa atggcgatta aaaagtataa accgacctct 137341 aatggacgtc gtggcatgac aacttcagat tttgctgaaa tcacgactga caagccggaa 137401 aaatccttgc ttgctcccct tcacaaaaaa ggcggacgta acaaccaagg taaattgact 137461 gtacgtcacc aaggtggcgg acataaacgc caataccgtg ttatcgactt caaacgcgat 137521 aaagatggta tacctggacg cgttgctaca gttgaatacg atccaaaccg ttcagctaac 137581 atcgctctaa tcaactatgc agacggagaa aaacgttaca ttcttgctcc taaaggaatt 137641 caagtaggta ctgaaatcat gtcaggtcct gaagctgaca ttaaagtagg taatgcactt 137701 ccacttatca acatccctgt tggtacagtt gtgcataaca ttgaattaaa acctggtaaa 137761 ggcggacagc ttgtacgttc agctggtaca tctgctcagg ttcttggtaa agaaggtaaa 137821 tacgttcttg tacgtcttaa ctctggtgaa gttcgcatga tcctttctgc ttgccgtgct 137881 tctatcggtc aagtaggtaa cgaacagcac gaacttatca acattggtaa agctggacgt 137941 tctcgctgga aaggcatccg tcctacagtt cgtggttctg taatgaaccc taacgatcac 138001 ccacacggtg gtggtgaagg acgtgcgcca atcggacgta aatcaccaat gtctccatgg 138061 ggcaaaccaa ctcttggatt caagactcgt aagaaaaaga acaaatccga taaatttatc 138121 gtacgtcgtc gtaaaaataa ataacggggt tgtctacggt tcttttcgga ccgtagtgca 138181 atcacgaagg gaggttccaa aatggctcgc agcttaaaaa aaggaccatt tgtcgatgga 138241 cacttgatga ctaaaatcga gaaattaaat gaaacagaca agaaacaagt cgtaaaaact 138301 tggtctcgtc gttctactat tttcccacag tttattggtc acacaatcgc agtctatgac 138361 ggacgtaaac acgtgcctgt attcatctct gaagatatgg tagggcacaa gttgggtgaa 138421 ttcgctccaa ctcgtacgta caaaggtcat gctagtgatg acaaaaaaac aagacgctaa 138481 gagaggaggc ttttaaatgc aagctaaagc tgttgcaaga acagtccgta ttgctcctcg 138541 taaagcacgt ctagtaatgg acctgattcg aggcaagcaa gtaggtgagg cagtatcaat 138601 cttgaacctt acaccaagag ctgcttctcc aattatcgag aaagtattaa aatccgctat 138661 tgcaaatgct gagcataact atgaaatgga cgctaacaac ctggttattt ctcaagcatt 138721 cgttgacgaa ggccctacgt taaaaagatt ccgcccacgt gctatgggac gtgcgagcca 138781 aatcaacaaa cgtacgagcc acattacaat cgttgtatca gaaaagaagg agggataagt 138841 agtgggtcaa aaggtaaatc cagtcggtct tcgtatcgga gtcattcgtg attgggaatc 138901 taagtggtac gctggtaaag attacgctga cttcctgcac gaagatttaa aaattcgtga 138961 atacattagc aaacgccttt ctgacgcttc tgtttctaaa gtagaaattg agcgtgcagc 139021 aaaccgcgtt aacattacga tccacacagc taagcctggt atggttatcg gtaaaggcgg 139081 ttctgaagtc gaagcacttc gcaaagccct taacagcctt actggcaagc gtgtacacat 139141 taacattctt gaaatcaaaa gagcagatct tgatgcacag ctagttgctg acaacatcgc 139201 tcgtcaatta gaaaaccgtg tttctttccg ccgtgcgcag aaacaacaaa tccaacgtac 139261 tatgcgtgct ggagcacaag gtgtgaaaac aatggtttct ggtcgtcttg gcggtgcaga 139321 tatcgctcgt tctgaatact acagtgaagg aactgttcca ttgcacacat tacgtgcgga 139381 cattgactat gcaacatctg aagctgatac tacttacggt aagcttggtg taaaagtctg 139441 gatctatcgt ggagaggttc ttcctactaa gaagaaaaat gaggaaggag gaaaataata 139501 tgttattacc aaaacgcgtt aaatatcgca gagagcatcg cggaaaaatg cgtggccgtg 139561 cgaaaggcgg tactgaagta catttcggag aattcggtat ccaagctcta gaagcttctt 139621 ggattactaa ccgtcaaatc gaagctgcac gtattgcgat gactcgttac atgaaacgtg 139681 gcggtaaagt ttggatcaaa attttccctt ctaaacctta cactgctaaa ccacttgagg 139741 tacgtatggg atccggtaaa ggggctccag aaggttgggt agctgttgta aaaccgggca 139801 aagttttatt tgaaatttct ggtgtgtctg aagaggttgc tcgtgaagcg cttcgccttg 139861 catctcacaa attgccaatt aaaacgaagt tcgtaaaacg tgaagaaatt ggtggtgaat 139921 caaatgaaag ctaatgaaat tcgtgacctt accactgctg aaattgaaca aaaagtaaag 139981 tctcttaaag aagaactttt caatcttcgc tttcaattag cgacaggaca acttgaaaat 140041 actgctcgca ttcgtgaagt gcgcaaagct atcgcgcgca tgaaaactgt gattcgtgaa 140101 agagaaattg ctgctaataa ataatcactg aggggaggtc gtgagcatga gcgaacgtaa 140161 ccaacgcaaa gtttaccaag gccgtgttgt ttctgacaaa atggataaaa ccattactgt 140221 tgttgttgag acatacaaaa aacatacact ttacggtaaa cgcgtaaaat actcaaaaaa 140281 attcaaagca catgatgaaa ataatcaagc taaaatcggt gacatcgtta agatcatgga 140341 aactcgtcca ttgtctgcaa ctaagcgttt ccgtctagtt gaagttgtcg aagaagctgt 140401 tattatctaa taaagttcgg aattcttttt ccgaagggag gtaacaaata atgattcaac 140461 aagagactcg tttaaaagta gctgacaact ctggcgcacg tgaagtactt actattaaag 140521 ttcttggtgg ttctggacgt aaaacagcta acattggtga tgtaattgtt tgcacggtta 140581 aacaagcaac accaggaggc gttgtcaaaa aaggtgaagt cgtaaaagct gttatcgttc 140641 gcactaaaag cggagcgcgc agaagtgacg gttcatacat cagcttcgat gagaatgcat 140701 gtgttatcat ccgtgacgac aagagcccac gcggaactcg tatcttcgga ccagttgctc 140761 gtgaattgcg tgaaaacaac tttatgaaaa ttgtttctct agctccagaa gttatctaat 140821 tgaaataaat gccttactca aggaggtgcg atcaggatgc atgtaaaaaa aggcgataaa 140881 gttatggtta tctctggtaa agataaaggc aaacaaggaa caatccttgc tgctttccct 140941 aaaaaggacc gcgttttagt tgaaggtgtt aacatggtaa agaaacactc taaaccaact 141001 caagctaacc ctcaaggcgg tatttctaat caagaggcgc caattcatgt atcaaacgtt 141061 atgccgctcg atcctaaaac aggtgaagtg actcgcgtag gatacaaagt ggaagatggc 141121 aaaaaagttc gtgtagcaaa aaaatctggg caagttctag ataaatagta ttaaaaggaa 141181 gggaggtcta tctcatgaac cgccttaaag aaaagtacaa taaagaaatt gcacctgctt 141241 taatgactaa gttcaactat gattcagtca tgcaagtgcc taaaatcgaa aaaatcgtaa 141301 tcaacatggg tgttggtgac gctgttcaaa acgccaaagc aatcgacagt gctgttgagg 141361 aattaacgtt tatcgcaggt caaaaacctg tcgttactcg tgcgaagaaa tcaattgctg 141421 gattccgtct tcgtgaggga atgcctatcg gtgcgaaagt aactcttcgc ggagagcgca 141481 tgtatgattt ccttgataaa cttatttctg tatctttacc gcgtgtacgt gacttccgcg 141541 gggtttctaa aaaatctttc gacggtcgcg gtaactacac acttggtatc aaagaacagt 141601 taatcttccc tgaaattgac tacgataaag taacaaaggt tcgcggaatg gacatcgtta 141661 tcgtaacaac tgctaatact gacgaagaag ctcgtgagct attaactcaa gtaggtatgc 141721 cgttccagaa ataatcaatg aaagggaggc gaaatcgtgg ctaaaaagtc tatgattgcg 141781 aaacaacaac gtacaccaaa gtttaaagta caagagtaca cacgctgtga acgctgcgga 141841 cgtccgcatt cagtcattcg taaatttaaa ctttgccgta tttgtttccg tgagcttgca 141901 tataaaggac aaattcctgg cgtgaaaaaa gccagctggt aatccccaag aaagggaagg 141961 aggtaattat ataatggtta tgacagatcc aattgcagat atgctaactc gtattcgcaa 142021 tgcaaacatg gtacgtcatg agaagcttga aattcctgct tctaaattga aaagagaaat 142081 tgctgaaatt ttaaagcgtg aaggtttcat tcgtgacgtt gagttcgtag aagacagcaa 142141 acaaggtatt atccgcgttt tcttgaaata cggacaaaac aacgagcgcg ttatcactgg 142201 tcttaaaaga atcagcaagc ctggtttgcg tgtttatgct aaatctaatg aagtaccccg 142261 cgtacttaac ggtcttggaa tcgcgattat ttctacatca caaggtgttt taacggacaa 142321 agaagcccgt gcaaaacaag ctggtggaga agttctagca tacgtttggt aagaagttta 142381 acatgaatgg aggtgtttgg tatgtctcgt gtaggtaaga agctacttga gattccttct 142441 gatgttacag taacgttaaa tgataacaac actgtagctg tgaaaggacc aaaaggagaa 142501 ttaactcgta cgtttcaccc tgatatggag attaaagtag aggacaatgt gcttacagtc 142561 gctcgtcctt ctgatcaaaa agagcaccgt gccctgcatg gtacgactcg cagtctgctt 142621 ggcaacatgg ttgaaggtgt atctaaagga tttgaaagag gtttggaatt agtcggtgtc 142681 ggttaccgtg cttctaaatc cggaaataaa cttgttttaa acgttggata ctctcatcct 142741 gttgagatcg ttcctgaaga aggcatcgaa atcgaagttc cttctcaaac aaaagtagtt 142801 gtaaaaggta cagacaaaga acgcgtagga gctattgctg ctaacatccg cgctgtacgt 142861 tctccagagc cttacaaagg taaaggaatc cgctacgaag gtgaagttgt tcgccgtaaa 142921 gaaggtaaat ctgctaagta agatcgctta aagtgaagaa aggagtgacc tagatgatta 142981 cgaaaactag caaaaatgct gctcgtctta aaagacacgc tcgtgttcgc gctaaacttt 143041 ccggtactgc tgaaagaccg cgcctgaacg ttttccgttc taacaagcac atttacgctc 143101 aaatcatcga tgatgtaaat ggtgtaacac ttgctagtgc atctactctc gataaagact 143161 tgaacgttga aagcactgga gatacttctg ctgctactaa agttggagaa ttagttgcaa 143221 aacgcgctgc tgaaaaaggc atttctgacg tagtatttga ccgtggcgga tacttatacc 143281 atggacgtgt aaaagctttg gctgatgccg ctcgtgaagc tggacttaaa ttttaataaa 143341 agaaggaggg acacatgatt atgcgtcgta ttgacccaag caaattagag ttagaagaac 143401 gcttagttac ggttaaccgc gtagcgaaag ttgttaaagg tggtcgtcgt ttccgcttcg 143461 cagctctagt cgttgtcggt gacaaaaacg gacacgtagg attcggtact ggtaaagcac 143521 aagaagtacc agaagcgatt cgcaaagctg ttgaagatgc gaaaaagaat ttgattgaag 143581 taccaatggt tggaactaca attccacacg aaatcatcgg acgtttcggt gcaggtaaca 143641 tcttgttaaa acctgcttct gaaggtactg gagttatcgc tggaggccct gtacgtgcgg 143701 tacttgagct agctggtgta gctgatatcc tttctaagtc tttaggttct aacacaccga 143761 tcaacatgat tcgtgcaaca cttcaaggtt taagtgaact taaacgtgct gaagacgttg 143821 cgaagcttcg tggaaaatct gtagaagaac tgttaggata aggagggaac attaatggct 143881 aaattagaaa ttaccctcaa acgaagtgta atcggtcgcc cggaagacca acgcgttact 143941 gtaagaacac ttggtttaaa gaaaacaaac caaactgttg ttcatgaaga caacgctgcg 144001 atccgtggta tgattaataa agtatctcat ttagtttctg ttaaagaaca ataaaaatat 144061 ttgatcggat aaggaggtgt cctaatgaaa cttcatgaat taaaaccttc agaaggttca 144121 cgcaaaacgc gtaatcgcgt aggtcgtggt attggttctg gcaacggtaa aacagctggt 144181 aaaggtcaca aaggtcaaaa cgctcgttct ggcggcggtg tacgccctgg attcgagggg 144241 ggacaaatgc ctttattcca acgtcttcct aaacgtggtt tcactaacat caaccgcaag 144301 gaatacgctg tagtcaacct agacaaattg aacggttttg cagaaggaac ggaagtcact 144361 cctgaacttc ttctagagac tggtgttatt agcaaactta atgcaggagt aaagattctt 144421 ggcaacggta aattagagaa aaaattaact gtaaaagcca ataaattctc tgcttctgcg 144481 aaagaagctg ttgaagctgc tggcggtaca gctgaggtga tctaacttgt ttaaaacaat 144541 ctccaacttt atgcgtgtga gtgatatcag gaataaaatc atattcactt tactcatgct 144601 tatcgtcttt cgcataggtg cgtttattcc tgtgccttac gttaacgctg aagcgttaca 144661 ggcacagtct caaatgggtg tttttgatct ccttaataca tttggcggcg gtgcgcttta 144721 ccaattttcc attttcgcaa tgggaattac tccttatatc acggcttcga tcatcattca 144781 gctgcttcag atggatgtgg taccgaagtt taccgagtgg tctaagcaag gtgaagttgg 144841 ccgccgtaaa ttagctcagt tcacaaggta ctttacgatt gtgcttggtt tcatccaagc 144901 gttaggtatg tcatatggat tcaacaatct ggcaaacggt atgctgatcg aaaaatccgg 144961 tgtatcgaca tatcttatca ttgctttagt gctcactggc ggaactgcct ttttaatgtg 145021 gcttggggaa caaattactt ctcatggagt aggcaacgga atatcgatca ttatcttcgc 145081 ggggattgtg tctagtattc caaaaacaat tgggcaaata tatgagactc aatttgtcgg 145141 cagcaacgat cagttgttta ttcatattgt gaaagtcgca cttcttgtga ttgcgatttt 145201 agcagttatt gttggagtta ttttcattca gcaagccgta cggaaaattg cgattcaata 145261 tgctaaaggc acaggtcgtt cacctgctgg cggaggtcag tctacacacc ttccattgaa 145321 agtgaatcct gcaggggtta ttccggtaat ctttgcggtt gcgtttttga taacgccgcg 145381 gacgatcgcg tcattctttg gaacaaacga tgtgacaaag tggattcaaa acaactttga 145441 taatacgcat ccggtgggta tggcgatata tgttgcgttg attattgcct ttacgtactt 145501 ttatgctttt gtacaggtaa accctgaaca aatggctgat aaccttaaaa aacagggtgg 145561 ctatatcccg ggggttcgtc cagggaaaat gactcaagat agaattacga gcattttgta 145621 tcgacttacg tttgtgggtt ctatattctt agccgtgatt tccattcttc ctatcttttt 145681 cattcaattc gctggattgc ctcaaagtgc acaaattggc ggaacatctt tgttaattgt 145741 tgtcggggta gccttggaga caatgaaaca actagaaagc cagttggtga aacgaaacta 145801 ccgtggattt atgaaaaact agaggaaatg gatttatcca ttccctctta ataaagagag 145861 gacgggggaa atccgaatga acttagtctt aatggggctt cctggtgccg gtaaaggcac 145921 acagggcgaa cgaattgttg aggattatgg gattcctcat atctcaacag gagatatgtt 145981 ccgtgctgct atgaaagaag aaacaccact cggactcgaa gcaaaatctt atattgataa 146041 gggagagctc gtacctgacg aagtcacaat cggaattgta aaagagagac ttggcaaaga 146101 tgattgtgaa agaggttttc ttctggacgg atttccgcga acagtcgctc aagccgaagc 146161 tcttgaagaa attcttgagg aatacggcaa gccgattgat tatgtcatta acattgaagt 146221 cgacaaagat gttctgatgg aacgtctgac tggacgcaga atttgcagtg tttgcggcac 146281 aacctatcat ttagtcttta atccgccgaa aacgccgggt atttgtgata aagacggagg 146341 cgaactctat caacgggcag atgataatga ggaaacagtc tctaaacggc ttgaggtaaa 146401 catgaagcaa actcagcctt tactcgattt ctattcagag aaaggttatc ttgcaaacgt 146461 gaatggccag caggacattc aagacgttta tgcagatgtg aaggatcttc ttggaggatt 146521 aaaaaaatga ttatctgtaa aaccccacgt gaacttggta tcatgcggga agcagggcga 146581 atcgtggctt taactcatga agagttaaaa aagcacatta aaccaggaat ctcgacaaaa 146641 gaattggatc aaattgccga acgttttatt aagaagcagg gtgcaatccc atcttttaag 146701 gggtataatg ggtttcgcgg gagcatttgc gtatcagtta atgaagaact cgttcacggc 146761 atacctggca gcagggtgct gaaggacggt gacatcatca gtattgatat cggtgctaaa 146821 ttaaatggtt atcatggtga ctctgcatgg acatatccgg taggaaacat cagcgatgat 146881 gacaaaaaac ttctggaagt gacagaggag tctttatata aaggcttgca ggaagcaaaa 146941 ccaggtgaac gtttgtcgaa tatttcccac gcaatacaaa cgtatgtcga aaatgagcag 147001 ttttcagttg ttagggagta tgtcggacat ggtgttggtc aagacttgca tgaggacccg 147061 caaattcctc attacggtcc gcccaacaaa ggaccacggc ttaaacctgg catggttctc 147121 gctattgaac ctatggtgaa cgctggcagc cgctacgtga aaacattggc tgataactgg 147181 acggttgtaa cggtagatgg gaaaaagtgt gctcattttg aacatacgat tgcgattacg 147241 gaaacgggtt ttgatatact gacgagagtc tagatgatga aaataattcc gaagacagat 147301 gtttttcaag cttgataggg cagaaagctt gggtgaacat tggcaagacc gaattcatct 147361 tgcttcttgt cgttggaatt ttaaccatca tcaatgtact aacagcagac ggagaaaagc 147421 gtacatttca ttctcctaag aaaaagaata tcaatcattt aaccctttat gattgcgtat 147481 ctccggaagt tcagaacagt ataaacgaaa cagggcgtgt gacaaacttc ttttgaaatt 147541 tgtcagaaag caagttactg atttgaagaa gggagaacac ttgaatggcg aaagacgatg 147601 taattgaagt ggaaggtact atagtcgaaa cactgccaaa cgcgatgttc aaagttgaac 147661 ttgaaaatgg ccacactgtt ttggctcatg tatctggtaa aatccgcatg cacttcattc 147721 gcattttacc tggagacaaa gttacggtag aattatctcc atatgactta actcgtggca 147781 ggattacgta ccgttacaaa taaagcactc cggaaactga aggaggttgg aaacacatga 147841 aagtgagacc atcagttaaa ccaatctgcg aaaaatgtaa agttattcgc agaaaaggaa 147901 aagtaatggt gatctgtgaa aatccaaagc ataaacaaaa acaaggataa tttataagga 147961 ggtgcccaga gaatggctcg tattgctggt gtagatatcc cacgtgacaa acgtgttgtt 148021 atttctttaa catacatctt cggaattggc cgcacaacgg ctcagcaagt tttaaaagaa 148081 gctggagttt cagaagatac tcgtgtgcgc gatcttactg aagaagaact tggtaaaatc 148141 cgtgatatta ttgacaaact gaaagtagaa ggtgaccttc gccgtgaagt ttctcttaat 148201 atcaaacgtc tgatcgaaat cggaagctac cgcggaatcc gtcatcgcag aggattacct 148261 gttcgcggac aaaactctaa aaacaacgcg cgtactcgta aaggtccgcg tcgtactgta 148321 gctaacaaga aaaaataagt aagggaggtt cttaaacaat ggctgctgct cgtaaatcta 148381 acacgcgtaa acgtcgcgtg aaaaagaata ttgagtctgg aattgctcat attcgttcaa 148441 ctttcaataa cacgatcgtt acgatcactg acactcatgg taatgctatt tcttggtcta 148501 gtgccggagc tttaggattc agaggttctc gtaaatctac tccttttgct gcgcaaatgg 148561 ctgcagaaac agctgctaaa ggttcaatcg aacatggtct taaaactcta gaggttactg 148621 ttaaaggacc tggttcaggc cgtgaagctg caatccgtgc acttcaagct gctggactag 148681 aagtcactgc tatcagagac gtaactcctg ttcctcataa cggatgccgt ccaccaaaac 148741 gtcgccgcgt gtaatttgtt tgtatagatt ttgtgtccct gtcaataatg ggttatgata 148801 cagttattta tgaaacgaat gcaccgactc gttgcctgag cacatacggg actaaacaat 148861 ggggaatttc ggatggaatc tcatatgatt ctattcgagg tttcgacgtt ttgaaggagg 148921 gttttaagta atgatcgaga ttgaaaaacc aaaaatcgaa acggttgaaa tcagcgacga 148981 tgccaaattt ggtaagtttg tcgtagagcc acttgagcgt ggatatggta caactctggg 149041 taactcctta cgtcgtatcc tcttatcctc actccctggt gccgctgtaa catcaatcca 149101 gatagatggt gtactgcacg aattctcgac aattgaaggc gttgtggaag atgttacaac 149161 gattatctta cacattaaaa agcttgcatt gaaaatctac tctgatgaag agaagacgct 149221 agaaattgat gtacagggtg aaggaactgt aacggcagct gatattacac acgatagtga 149281 tgtagagatc ttaaatcctg atcttcatat cgcgactctt ggtgagaatg cgagtttccg 149341 agttcgcctt actgctcaaa gaggacgtgg gtatacgcct gctgacgcaa acaagagaga 149401 cgatcagcca atcggcgtga ttccgatcga ttctatctat acgccagttt ctcgtgtatc 149461 ttatcaggta gagaacactc gtgtaggcca agttgcaaac tatgataaac ttacacttga 149521 tgtttggact gatggaagca ctggaccgaa agaagcaatt gcgcttggtt caaagatttt 149581 aactgaacac cttaatatat tcgttggttt aactgacgaa gctcaacatg ctgaaatcat 149641 ggttgaaaaa gaagaagatc aaaaagagaa agttcttgaa atgacaattg aagaattgga 149701 tctttctgtt cgttcttaca actgcttaaa gcgtgcgggt attaacacgg ttcaagagct 149761 tgcgaacaag acggaagaag atatgatgaa agttcgaaat ctaggacgca aatcacttga 149821 agaagtgaaa gcgaaactag aagaacttgg actcggactt cgcaaagacg attgactagt 149881 ttcccttgtg aactaggatt ttcgtgtgtt tattattcag aaacagcatt ccaataaagg 149941 aggggacatc acatgtcata cagaaaacta ggacgtacga gtgcacagcg taaagctatg 150001 cttcgtgatc ttacaactga tttgatcatc aacgaaagaa tcgaaacaac tgaaacacgt 150061 gcgaaagaac ttcgctctgt agttgaaaaa atgatcacgc ttggcaaacg cggtgatctt 150121 cacgctcgcc gtcaagctgc tgcatacatc cgcaacgagg ttgcaaacga agaaaataat 150181 caagatgcac ttcaaaaatt attctctgac attgcaactc gttacgagga gcgccaaggt 150241 ggatacacac gtattatgaa gcttggtcct cgccgtggtg acggagcacc aatggcaatt 150301 atcgaattgg tttaatcaca tatttttgtg tatctaaaga agggcgggac agtttctaac 150361 tggatctatg cccttttttt agatactgca acttttaata gagagaaaag cagagcatta 150421 gctgagagga ggccggtttt ccatgaatca aaatcagttg atatcggtag aggatatcgt 150481 atttcgatat cggaaggacg cagaaagacg agcactagac ggcgtctccc tgcaggtgta 150541 tgagggtgaa tggcttgcaa tcgtaggtca taacggttca gggaaatcaa cactggcccg 150601 ggcattgaat ggtttaattc ttcctgaatc aggcgacatt gaggttgccg ggattcaatt 150661 gacagaggaa tctgtttggg aagtgcgtaa gaagataggt atggtctttc aaaatccgga 150721 taaccaattt gtcggaacga ctgttcgcga tgatgtggct tttggtttag aaaacaatgg 150781 tgtaccgcgg gaagaaatga ttgagagagt agactgggca gtaaaacagg tgaatatgca 150841 agattttctc gatcaagagc cgcaccatct ctccggaggc caaaagcaga gagttgcgat 150901 tgcgggggtt attgccgcac gtcctgatat tattatctta gatgaagcaa catccatgct 150961 tgatccgatc gggcgagaag aagtgcttga aacggtaaga catttaaaag agcagggcat 151021 ggcgactgtc atatccatta cacatgacct gaatgaggca gcaaaagcag acaggatcat 151081 tgtcatgaat ggcggtaaaa aatatgctga agggccgcct gaagagattt ttaaattgaa 151141 taaagaactt gttcgaattg ggcttgattt acccttctca ttccagctta gccagctttt 151201 aagagaaaat ggactggctt tggaagaaaa ccatttgact caggaagggc tggtgaaaga 151261 gctgtggaca ttacaatcaa agatgtagag catcgctatc agatgaagac cccgtttgag 151321 cgcctagcac tgtatgatat caatgcatcg attaaagaag gaagctacgt agccgttatc 151381 gggcatacag gctctggcaa gtccactctt ctacagcacc taaatggtct cctgaagccg 151441 acgaagggac agatatcact aggcagcact gtcattcagg cagggaaaaa gaataaagat 151501 ctgaaaaaac ttcgtaaaaa agtcggaatc gttttccaat ttcctgagca tcaattattc 151561 gaagaaacag ttcttaaaga tatttcattc ggaccgatga actttggtgt taaaaaagaa 151621 gatgctgaac aaaaagcgag agagatgctg cagcttgtag gtttatcaga agagcttttg 151681 gacaggtcac cctttgaatt aagcggggga caaatgcgca gagttgcaat tgccggcgta 151741 cttgcaatgg accctgaagt gcttgttctg gatgaaccga ctgcaggatt ggacccaaga 151801 gggcgaaaag agattatgga catgttttat gagcttcatc aacgtgggaa cttgacgacg 151861 atccttgtga cacacagcat ggaggatgca gctgcatacg ctgatgaaat gattgttatg 151921 cataaaggaa cgatacaagc atcaggcagt ccgcgtgatc tgtttttaaa gggtgaagag 151981 atggccggct gggggctgga tcttcctgaa acaataaaat tccaaagaca ccttgaagct 152041 gcactgggtg tgagatttaa tgagcctatg ctcacaatcg aagatgccgc tgccgaaatc 152101 cgtgctcttt ttcagggaga gaagacttta tgatggacag catgattatc ggcaagtatg 152161 taccggggac ttcacttgtg caccggcttg accccagaac aaaactgatc acgatctttt 152221 tatttgtctg cattgtattc ttagccaata atgttcagac atatgcgttg cttggtttat 152281 ttacaattgg cgtcgtttct ttaacaagag ttcctttctc ttttttaatg aaagggctga 152341 agccaatcat ctggattgtc ctttttacgt tccttcttca cattcttatg acacatgaag 152401 gaccgattat ctttcaaata ggttttttca aagtctatga gggcggtctg gttcagggga 152461 tattcatttc tcttagattc gtctatttga ttttaatcac aaccttatta acgcttacga 152521 ctacaccgat tgagattacc gatggaatgg agcagctgct gaacccattg aaaaaattaa 152581 agcttcctgt tcatgagctg gctcttatga tgtcaatttc tttacggttt attccgacac 152641 tgatggagga gacagataag atcatgaagg ctcagatggc gcgaggcgtt gattttacaa 152701 gcgggcctgt caaagaaaga gtgaaggcta ttgtcccgct tcttgtcccg ctcttcgtca 152761 gcgcatttaa acgcgccgaa gagcttgcgg tggcaatgga agcaagaggc tatcaaggcg 152821 gagaaggacg tacgaaatat agaaagcttg tatggacagg aaaagacact tctgtcattg 152881 tcagcttaat tgtattagct gctttgttat ttttcttaag ggcttagagg tgctgtatga 152941 gactgaaatg cacgatttct tatgacggac atttgtttaa cggttatcag gttcagccgg 153001 gcaaaagaac ggttcaggat gaactggaga aggctttggc tgtcctgcat aagtcaaaag 153061 acagaattcc ggtcgtttcg tctggaagaa cagacagcgg ggttcacgca gccggacagg 153121 tgattcattt tgacactccg ctgtctatcc cggctgagag atggccatat gccttaaatg 153181 cactgcttcc ggacgatatc gcagtcaaac aggcagaaat tgcggatgat gggttccatg 153241 cacgatttag cgcagtcaaa aaagaatatc gctactttgt atacacggag aaacacccgg 153301 acgtatttaa acggcattac gcttaccatt tttcatatcg ccttaatgtg caggacatga 153361 gagaagcggc aaagcatctt atagggacac atgattttac gagcttttgc gcggctaaaa 153421 cagaagtgca ggacaaggta agaacgatat acgaacttga ttggactgag acggctgacg 153481 gcctgcaaat gcggatcaca ggcagcggtt tcttatataa tatggtcaga attattgcgg 153541 gtactttgct tgatgcaggt attggaaaaa tttctcccga tgaggtgaaa tccatgctgg 153601 aagcgaagga tcgcgaagcg gcagggcgca cagcgccggg gcacgggcta tatttatgga 153661 acgtttacta tgacaactaa accaggtgta taatattttc ttgacagagt ctgcataaag 153721 ttataagata tcatatggta tgtatttcaa ccccacgata agccccggaa cttattgtgt 153781 tgtgaaatag aacgtaatcg aagtttattg aaaatgacag atcatttagg agggaaattc 153841 aatgcgtaca acacctatgg ctaacgcaag tactattgaa cgcaagtggt tagttgttga 153901 tgctgctggc aagactttag gtcgtctttc ttcagaagtt gcagctatcc ttcgcggaaa 153961 acacaaacca acttacacac cacacgttga tactggagat catgtgatca tcatcaacgc 154021 tgaaaaaatc gagttaactg gtaaaaagtt aactgacaaa atctactacc gtcacactca 154081 acatccaggc ggattaaaat caagaactgc tcttgaaatg cgtacaaact accctgagaa 154141 aatgcttgag cttgctatca aaggcatgct tccaaaaggt tctctaggtc gtcaaatgtt 154201 caaaaaattg aacgtatacc gtggttctga gcatccacac gaagcacaaa aacctgaagt 154261 ttacgaactt cgcggttaat taaaaaggag gttaccaatt tggcacaggt tcaatattac 154321 ggtactggcc gtcgtaaaag ctctgtagcg cgtgtgcgtt tagttccagg agaaggccgt 154381 atcgtcgtta ataatcgtga aatcagcgaa catatcccat ctgcagcttt aatcgaagat 154441 atcaaacaac cattaacttt gactgaaaca gctggcactt atgatgtttt agtaaacgta 154501 catggaggcg gcctatctgg tcaagctgga gcaatccgtc acggtatcgc tcgtgctttg 154561 cttgaagcag atccagaata ccgtacaact cttaaacgtg caggtcttct gactcgtgac 154621 gctcgtatga aagaacgtaa aaaatacggt cttaaaggcg ctcgtcgtgc acctcagttc 154681 tcaaaacgtt aattttacgt tttcaaaaag ctctcgacct tgggttggga gcttttttct 154741 ttcaataaaa cgtggcagtc ccgcataaaa ataacaactg aatggacgct tgacggggtt 154801 aagcaaattg tttgtttata aacggtctct ttgtaataat catggtagat ttcattctta 154861 ttcaattgga agttcggtca atgtttatta tcgttatgtg atcagcccag ctccatctaa 154921 ccactgtatc tcatccgtta aagttcactg ctgattctta acccggagaa acaatagctc 154981 tcattgctaa tggctttatg taacgaagta aaagtaaatc tgatgatata aatcacatat 155041 ctcctttgtg atttttttgc gtttttatga acttttttct aaatatgcaa agggaaagcg 155101 atatcaatct agaaatattt gttatactct atacattaaa gtaaggagaa gattcatgaa 155161 tgcgttagta gctcataata gcaaagcctg ggataaaaaa gtagaaacag gcaatgaatg 155221 gactgttgct gttgaacagc aggttatcga acaagcaaaa aaaggcaatt gggatataag 155281 ggtaacacca atgaaagatg taccgaagga ttggtttccg cctatcaaag gtctgaaagt 155341 actctgttta gcatcaggcg gcggccagca gggtccagtt ttggcagccg caggcgcgga 155401 tgtcactgta ttagataact cagaaaaaca gctgaatcag gatagaatga ttgctgagcg 155461 agatggtctg acgatacaca ctgtcaaagg aagcatggac gatttaagtg tatttaatga 155521 tgaatcattt gatgtcattg tacatcctgt tgccaatgtt tttgttgaga atgtcctccc 155581 ggtatggaag gaagcgtacc gtgtgttgaa aaggaacggc attctaatct cgggttttgt 155641 caatcctgtt gtatttctgt ttgatacaga attagaacag caaggtgttt taaaagtaaa 155701 acactctatt ccatacgctg acccagaaga tcttccgaaa cataaagtga aaaaactgat 155761 cgaaaataat gaggctctgg aattcggcca ttccttagaa gaccaaatca aaggccaaat 155821 tgatgccggt tttatcgtta ctggttttta tgaagataaa ggcggttttg tattagacca 155881 atatatccat acatattctg caacaagaag cgtgaaagta tgaaaagcag cgacctgtta 155941 gaggggctgc ttttttcata accaattaca gaacatttgt tcctcaccct gcagaaagct 156001 gattttttat caatgttaca ccttcatttg ggcgaatttc caaccgaatt cgggcattgt 156061 ttcatcatcc aaacctcaaa ataatcggta aaaggagagt gaatttatat ggcagaagta 156121 ctgtctttta tggatgtgaa acgccaaaag gattttgaat tagaaaagaa cttgctcaaa 156181 gaactctctc tgagacaaat tatccagtct gttaaggatt gtttggaacc attatttcca 156241 tttttacatg atgaacgaga tattattacc gaaggctgta ttgattttgc gattgaagct 156301 tatttgttag gcgggcgttt tgggatattc ggctattacg gagaatcaat gcagagtatc 156361 agtgcccgct ctgcaagaga agaagaagag ctgcgtatgg agttttttga ttatctctat 156421 aattggatac acgagcaata cgcaacattt gataaaaaca ctgtttatga agcggcacgc 156481 aagttcatta aagattggtg gacagcaggg tttgttcaaa gagaaaaaca gtgtaagctt 156541 cgcatgcggt aatcatattt cccgaccctg tcccatagtt atgtaataac ggacaagcgg 156601 gaggggaagg gatgaggaaa aagcttaaat ggctcagttt tttgctaggc ttcatcatat 156661 tactatttct gttcaagtat cagttcagca ataacgactc ttggaagccg tggagcctgc 156721 ccttgagcgg taaaatcatt tatctagatc caggtcatgg cgggcctgac ggcggagcag 156781 tcggcggaaa gctgttagag aaggatgtta ccctggaagt ggcctttaga gtcagggatt 156841 atcttcaaga acaaggagcg cttgttatca tgaccagaga aagtgatact gatctcgctc 156901 cagaaggaac aaaaggctat agccgacgaa aagctgagga tctaagacaa cgagtcaaat 156961 taataaacca ttcagaggcg gagctctata tcagcattca tcttaatgcg attccgtcac 157021 aaaaatggag cggagcccaa agcttttatt acgggaaata tgcggaaaat gagaaagtcg 157081 caaaatacat tcaggatgag ctgagaagaa atctggaaaa cacaacccgg aaagcaaagc 157141 ggattcatgg tatctactta atgcaaaacg tcaccaaacc gggggcgctt atagaagtcg 157201 gatttttatc caatccaagt gaagcaacgt tgctcggtaa accgaaatat caagacaagg 157261 tggcatcttc catatataaa ggcattttgc gatatttcac agaaaaagga gaccctccgg 157321 agtaatggag ggttttcttg tggttctaag cataagacac ccgccattta tgtatgatat 157381 aataataatt gtaaacgaat acacaaaagg gtgaggttcg atgataagag aagatgaagt 157441 aagaaaacta gtcggagaaa tgcgcgaacc ttttcttcaa agacctctgg gagaattgga 157501 tgccgttaag gaaattaaaa taaagcctga aaaacggcat atcagtgtaa aagtcgctct 157561 tgcaaaaaca ggaactgcag aacaaatgca gattcagcaa gagatcgtaa acgtattaaa 157621 aggggcagga gctgagacag tcggccttcg atttgaagag ctgcctgaag aaacggttgc 157681 taaattccgg gcgccgtcag ctgagaaaaa aacattatta aatatggata acccgccagt 157741 ctttcttgct gtagcaagtg gaaaaggcgg cgtaggcaag tcaactgtgt cagtaaacct 157801 agctatttct ctggctcgtc tagggaaaaa ggttggttta attgatgcgg atatttatgg 157861 gttcagtgtg ccggacatga tgggtatcac tgtgcgtcca acaattgaag gagagaaact 157921 tcttcctgtt gaacgctttg gagtaaaggt catgtcaatg ggctttttcg tagaagaaaa 157981 tgccccggtc gtatggagag ggccgatgct cggcaaaatg ctgaataatt ttttccatga 158041 agtagagtgg ggagaagtag actatatcgt tcttgatctt ccgcctggta caggggacgt 158101 tgctctcgat gtacatacaa tgcttccgag ctgcaaagaa attatcgtat ctacgccaca 158161 tccgacagct gcttttgtcg cggccagagc gggctctatg gcgattaaaa ccgatcatga 158221 ggtcgtgggt gtcatagaga acatggctta ttatgaaagt gcaaagacag gggaaagaga 158281 atatgtgttt ggaaaaggcg gaggagataa actggctgag gaactaaacg tgcctttgct 158341 cggcagaatc ccattgaaac agcccgattg ggataaggac caatttgctc cgtctgttta 158401 tgacgaaaat catccaatcg gagaaatata tcaggacatc gcaaaaaaaa tagatgcaaa 158461 aatgtcagtg caggtataaa aggtgaaccg ggattccaga tcccggcttt ccctttattc 158521 actttctttt gctgtgtctt ttgctgcttt tttcagctca tcttcgaact gctttttgta 158581 aagcggacta gaaagtgttt cgttaataac ctcttctaaa taactgcgga attcttggct 158641 ttttgccagc tggctgtact ttttatccat gccgggatcc tgcataacgc tcatcagcat 158701 cttctggtaa tctggatcct tcatcagctt tttaatcact ttttcatgct ctgtctgaag 158761 agttttggca aagccctcag caaaatcagt gtcttcaaag atgtttttcc aaaattcttc 158821 acctttttta gatgtgagtg ttttttctat tgttccttta attgcatctt ggtcaatcac 158881 cagcgcttca ttcatggcat catcatttaa taattcctta atagctttct ttccatcatc 158941 agtttttaat atatcaacaa ccattttttt ggtctgatca tagtccatat ccgctgcttg 159001 gtcttttgga gcgcaagctg ttacagataa taacaaaaaa cagctcatca atagcgtttt 159061 ggcttttgac atgcttaagc tcctttcaca tacttgtctt acctttaata tgattcatct 159121 gtttggaatt atacataaca aaatatcgct gttcgcgatt tttgagggga tgaataaaga 159181 aatgaaaagc cgtggtttag ttcgtttttt cttttctatt ttagctgtcg gggcgcttat 159241 cacgagtatt gtgggttttg ctttaaagtg gggagaatat agagggctgt ttctaacatt 159301 tgaagcggga cagattttct ctgttttatt ttggtttatc ggtgtaggca tgattttcag 159361 tgtgatcagc caaatgggtt ttttcgtgtt tttaacagtt catcggtttg cgcttgagat 159421 attaaggtcc tcctctttgt ggaatttgct gcagttgttt ttcatcctgt ttgttgcttt 159481 tgatttaatg tacgtgcgtt ttttattttt tggagagagc ggagaatcgc tggctggcta 159541 tgcgtggtta ccggtgtttt tattgatctt tggagtgatt acagcttata taaagcaaaa 159601 gcagtcctct aagaaaacat ttgtgtcatc gttatttttg atggttgtga ttaccgcatt 159661 agaatggttc cctgcattaa gagtaaatga tgaggactgg ctttatttaa tgctttttcc 159721 gttaatggca tgtaatgcct tccaattgct gatgctgccg aagtttgcag caaagtaatt 159781 actttacctc tgcggatttg gcatcagaat ttgcgatgag atcacccacg gttacatttt 159841 ttaatccttt ttctttcagc tgatggatga tatcaggcaa tgcttcttct gtttgttttg 159901 cagaatcgga ggcatgtaaa agaataatgt ctccaccgga aacttgcttg gtcacattgt 159961 cgatgatttt ttcaactccg ggatttgtcc agtcttgaga gttcacactg taatgaacga 160021 ctgtataatt gtattgcttt gcgaccttta gaacattctt attgaattgg ccggtagggg 160081 gtcttaatag ctgtatgtct ttgaccccta acttttcaaa ggctgtttgc gcacggttca 160141 tgtccttttt tatttcgctg ctctctaaat tggcatagtt tttataagcg tagcccatgc 160201 tcccgatttg atggccgtcc tttacgatac gggccactgt gtcgggatgg cgttctgccc 160261 aagaagcgga caggaaaaac gttgcgtttt taatcccgtt tgctttcaga gtattaagta 160321 tcggttctgc tctctcatca ccccagctga tatcgaaagt aagtgaaata tctttagagt 160381 ctgtttctcc tttataaatg gctttaggtc cggtgtcagt tgaaaacacg ggaagcggga 160441 cagctctttg gatataaaaa aagctggcag ctgcaaatgc ggcgataagt ataataatta 160501 attgttttac ccgtttaatg tgccacacat agaagtgatt cactgatgat gcctccttat 160561 cttgtccatc attcttgttt tacatcttat gagcatggac aattgaatat aaccgataaa 160621 atgtctcttc acatacagcc taaattgggt gttgaccttt tgataatatc cgtgatatat 160681 tattattcgt cgctgataaa cagctgacat caactaaaag cttcattaaa tactttgaaa 160741 aaagttgttg acttaaaaga agctaaatgt tatagtaata aagctgcttc gttaagcggc 160801 agtaatgatc tttgaaaact aaacaagaca aaacgtacct gttaattcat ttttataaat 160861 cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat cctggctcag 160921 gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg gagcttgctc 160981 cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta agactgggat 161041 aactccggga aaccggggct aataccggat ggttgtttga accgcatggt tcaaacataa 161101 aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag ttggtgaggt 161161 aatggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc cacactggga 161221 ctgagacacg gcccagactc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 161281 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 161341 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 161401 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagctt tgtccggaat 161461 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 161521 accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca 161581 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 161641 gtctgtaact gacgctgagg agcgaaaacg tggggagcga acaggattag ataccctggt 161701 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 161761 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 161821 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 161881 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 161941 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 162001 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 162061 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 162121 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 162181 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 162241 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 162301 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 162361 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 162421 gtgcggctgg atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta 162481 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 162541 ttgaaaacta gataacagta gacatcacat tcaagtaata caagatatca catagtgatt 162601 ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta ggagccgatg 162661 aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg atccggagat 162721 ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga attcatagga 162781 tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag agaaagcaaa 162841 tgcgattccc tgagtagcgg cgagcgaaac gggattagcc caaaccaaga ggcttgcctc 162901 tggggttgta ggacactctg tacggagtta caaaggaacg aggtagatga agaggtctgg 162961 aaaggcccgc cataggaggt aacagccctg tagtcaaaac ttcgttctct cctgagtgga 163021 tcctgagtac ggcggaacac gtgaaattcc gtcggaatcc gggaggacca tctcccaagg 163081 ctaaatactc cctagtgacc gatagtgaac cagtaccgtg agggaaaggt gaaaagcacc 163141 ccggaagggg agtgaaagag atcctgaaac cgtgtgccta caagtagtca gagcccgtta 163201 acgggtgatg gcgtgccttt tgtagaatga accggcgagt tacgatctcg tgcaaggtta 163261 agcagaagat gcggagccgc agcgaaagcg agtctgaata gggcgcatga gtacgtggtc 163321 gtagacccga aaccaggtga tctacccatg tccagggtga agttcaggta acactgaatg 163381 gaggcccgaa cccacgcacg ttgaaaagtg cggggatgag gtgtgggtag gggtgaaatg 163441 ccaatcgagc ctggagatag ctggttctct ccgaaatagc tttagggcta gcctcaaggt 163501 aagagtcttg gaggtagagc actgattgga ctaggggccc ctaccgggtt accgaattca 163561 gtcaaactcc gaatgccaat gacttatcct tgggagtcag actgcgagtg ataagatccg 163621 tagtcgaaag ggaaacagcc cagaccgcca gctaaggtcc caaagtatac gttaagtgga 163681 aaaggatgtg gagttgctta gacaaccagg atgttggctt agaagcagcc accatttaaa 163741 gagtgcgtaa tagctcactg gtcgagtgac tctgcgccga aaatgtaccg gggctaaacg 163801 tatcaccgaa gctgcggact gttcttcgaa cagtggtagg agagcgttct aagggctgtg 163861 aagccagacc ggaaggactg gtggagcgct tagaagtgag aatgccggta tgagtagcga 163921 aagaggggtg agaatcccct ccaccgaatg cctaaggttt cctgaggaag gctcgtccgc 163981 tcagggttag tcgggaccta agccgaggcc gaaaggcgta ggcgatggac aacaggttga 164041 tattcctgta ccacctcctc accatttgag caatgggggg acgcaggagg atagggtaag 164101 cgcggtattg gatatccgcg tccaagcagt taggctggga aataggcaaa tccgtttccc 164161 ataaggctga gctgtgatgg cgagcgaaat atagtagcga agttcctgat tccacactgc 164221 caagaaaagc ctctagcgag gtgagaggtg cccgtaccgc aaaccgacac aggtaggcga 164281 ggagagaatc ctaaggtgat cgagagaact ctcgttaagg aactcggcaa aatgaccccg 164341 taacttcggg agaaggggtg ctctgttagg gtgcaagccc gagagagccg cagtgaatag 164401 gcccaggcga ctgtttagca aaaacacagg tctctgcgaa gccgtaaggc gaagtatagg 164461 ggctgacgcc tgcccggtgc tggaaggtta agaggagcgc ttagcgtaag cgaaggtgcg 164521 aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct 164581 tgtcgggtaa gttccgaccc gcacgaaagg cgcaacgatc tgggcactgt ctcaacgaga 164641 gactcggtga aattatagta cctgtgaaga tgcaggttac ccgcgacagg acggaaagac 164701 cccgtggagc tttactgcag cctgatattg aatgttggta cagcttgtac aggataggta 164761 ggagccttgg aaaccggagc gccagcttcg gtggaggcat cggtgggata ctaccctggc 164821 tgtattgacc ttctaacccg ccgcccttat cgggcgggga gacagtttca ggtgggcagt 164881 ttgactgggg cggtcgcctc ctaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg 164941 ttggaaatca ttcgcagagt gtaaaggcac aagggagctt gactgcgaga cctacaagtc 165001 gagcagggac gaaagtcggg cttagtgatc cggtggttcc gcatggaagg gccatcgctc 165061 aacggataaa agctaccccg gggataacag gcttatctcc cccaagagtc cacatcgacg 165121 gggaggtttg gcacctcgat gtcggctcat cgcatcctgg ggctgtagtc ggtcccaagg 165181 gttgggctgt tcgcccatta aagcggtacg cgagctgggt tcagaacgtc gtgagacagt 165241 tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga gctgtcctta gtacgagagg 165301 accgggatgg acgcaccgct ggtgtaccag ttgttctgcc aagggcatcg ctgggtagct 165361 atgtgcggac gggataagtg ctgaaagcat ctaagcatga agcccccctc aagatgagat 165421 ttcccattcc gcaaggaagt aagatccctg aaagatgatc aggttgatag gtctgaggtg 165481 gaagtgtggc gacacatgga gctgacagat actaatcgat cgaggactta accatatttt 165541 tgaatgatgt cacatctgtt atctagtttt gagagaacac tctcaatttg tttggtggcg 165601 atagcgaaga ggtcacaccc gttcccatac cgaacacgga agttaagctc ttcagcgccg 165661 atggtagtcg ggggtttccc cctgtgagag taggacgccg ccaagcagat ttattaattc 165721 taccatgttt gtttatgaag ctttatatct cattccgcag tagctcagtg gtagagctat 165781 cggctgttaa ccgatcggtc gtaggttcga atcctacctg cggagcattg cttccatagc 165841 tcagcaggta gagcacttcc atggtaagga agaggtcagc ggttcgagcc cgcttggaag 165901 cttaaatgta ttattaccaa ggtttctcat aaggagaaag ctttttttat tgcgatatgc 165961 ggaagtagtt cagtggtaga acaccacctt gccaaggtgg gggtcgcggg ttcgaatccc 166021 gtcttccgct ccatttacct aacgggatat tgtaaattga attgcgcccg tagctcaatt 166081 ggatagagcg tttgactacg gatcaaaagg ttaggggttc gactcctctc gggcgcgcca 166141 tatcttttaa tagaatagat aggaaatcgg gaagtagctc agcttggtag agcacatggt 166201 ttgggaccat ggggtcgcag gttcgaatcc tgtcttcccg accatttttt atggggcctt 166261 agctcagctg ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg 166321 ctccaccaaa agtttttaaa aaaggttatt gactttgaag aagtgacatt gtatactaat 166381 aaagttgctt taacaaagcg gacaaacaaa atgatctttg aaaactaaac aagacaaaac 166441 gtacctgtta attcagtttt taaaaatcgc acagcgatgt gcgtagtcag tcaaactact 166501 ttatcggaga gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa 166561 gtcgagcgga cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg 166621 tgggtaacct gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt 166681 tgtttgaacc gcatggttca aacctaaaag gtggcttcgg ctaccactta cagatggacc 166741 cgcggcgcat tagctagttg gtgaggtaac ggctcaccaa ggcaacgatg cgtagccgac 166801 ctgagagggt gatccggcca cactgggact gagacacggc ccagactcta cgggaggcag 166861 cagtagggaa tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga 166921 aggttttcgg atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg 166981 gtaccttgac ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa 167041 tacgtaggtg gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct 167101 taagtctgat gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt 167161 gagtgcagaa gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag 167221 gaacaccagt ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg 167281 gggagcgaac aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt 167341 tagggggttt ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta 167401 cggtcgcaag actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt 167461 ggtttaattc gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta 167521 gagataggac gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg 167581 tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc 167641 attcagttgg gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg 167701 tcaaatcatc atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag 167761 ggcagcgaaa ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt 167821 ctgcaactcg actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg 167881 aatacgttcc cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga 167941 agtcggtgag gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga 168001 agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat 168061 tatacggaat ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt 168121 gaaggatcat tccttcgaaa cgtgttcttt gaaaactaga taacagtaga catcacattc 168181 aagtaataca agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg 168241 gtggatgcct tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg 168301 agctgtaagc aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg 168361 agtggtatcc atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat 168421 ctaagtaccc ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg 168481 gattagccca aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac 168541 aaaggaacga ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt 168601 agtcaaaact tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg 168661 tcggaatccg ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc 168721 agtaccgtga gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc 168781 gtgtgcctac aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa 168841 ccggcgagtt acgatctcgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga 168901 gtctgaatag ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt 168961 ccagggtgaa gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc 169021 ggggatgagg tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc 169081 cgaaatagct ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac 169141 taggggcccc taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt 169201 gggagtcaga ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag 169261 ctaaggtccc aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga 169321 tgttggctta gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact 169381 ctggcccgaa aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac 169441 agtggtagga gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt 169501 agaagtgaga atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc 169561 ctaaggtttc ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg 169621 aaaggcgtag gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc 169681 aatgggggga cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt 169741 aggctgggaa ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata 169801 tagtagcgaa gttcctgatt ccacactgcc aagaaaagct ctagcgaggt gagaggtgcc 169861 cgtaccgcaa accgacacag gtaggcgagg agagaatcct aaggtgatcg agagaactct 169921 cgttaaggaa ctcggcaaaa tgaccccgta acttcgggag aaggggtgcc ctgttagggt 169981 gcaacccgag agaaccgcag tgaataggcc ccaggcgact gtttagcaaa acacaggtct 170041 ctgcgaagcc gtaaggcgaa gtatagggct gacgcctgcc cggtgctgga aggttaagag 170101 gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat 170161 aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca 170221 acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca 170281 ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg 170341 ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca cttcggtgga 170401 ggcatcggtg ggatactacc ctggctgtat tgaccttcta acccgccgcc cttatcgggc 170461 ggggagacag tgtcaggtgg gcagtttgac tggggcggtc gcctcctaaa aggtaacgga 170521 ggcgcccaaa ggttccctca gaatggttgg aaatcattcg cagagtgtaa aggcacaagg 170581 gagcttgact gcgagaccta caagtcgagc agggacgaaa gtcgggctta gtgatccggt 170641 ggttccgcat ggaagggcca tcgctcaacg gataaaagct accccgggga taacaggctt 170701 atctccccca agagtccaca tcgacgggga ggtttggcac ctcgatgtcg gctcatcgca 170761 tcctggggct gtagtcggtc ccaagggttg ggctgttcgc ccattaaagc ggtacgcgag 170821 ctgggttcag aacgtcgtga gacagttcgg tccctatccg tcgcgggcgc aggaaatttg 170881 agaggagctg tccttagtac gagaggaccg ggatggacgc accgctggtg taccagttgt 170941 tctgccaagg gcatcgctgg gtagctatgt gcggacggga taagtgctga aagcatctaa 171001 gcatgaagcc cccctcaaga tgagatttcc cattccgcaa ggaagtaaga tccctgaaag 171061 atgatcaggt tgataggtct gaggtggaag tgtggcgaca catggagctg acagatacta 171121 atcgatcgag gacttaacca tatttttgaa tgatgtcaca cctgttatct agttttgaga 171181 gaacactctc aatttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 171241 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 171301 acgccgccaa gcaattgcac attagtgtaa ttttttaaaa aagttattga ctttgaagaa 171361 gtgacattgt atactaataa agttgcttta acaaagcgga caaacaaaat gatctttgaa 171421 aactaaacaa gacaaaacgt acctgttaat tcagttttta aaaatcgcac agcgatgtgc 171481 gtagtcagtc aaactacttt atcggagagt ttgatcctgg ctcaggacga acgctggcgg 171541 cgtgcctaat acatgcaagt cgagcggaca gatgggagct tgctccctga tgttagcggc 171601 ggacgggtga gtaacacgtg ggtaacctgc ctgtaagact gggataactc cgggaaaccg 171661 gggctaatac cggatggtta gtttgaaccg catggttcaa acataaaagg tggcttcggc 171721 taccacttac agatggaccc gcggcgcatt agctagttgg tgaggtaacg gctcaccaag 171781 gcaacgatgc gtagccgacc tgagagggtg atcggccaca ctgggactga gacacggccc 171841 agactcctac gggaggcagc agtagggaat cttccgcaat ggacgaaagt ctgacggagc 171901 aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct ctgttgttag ggaagaacaa 171961 gtaccgttcg aatagggcgg taccttgacg gtacctaacc agaaagccac ggctaactac 172021 gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt ccggaattat tgggcgtaaa 172081 gggctcgcag gcggtttctt aagtctgatg tgaaagcccc cggctcaacc ggggagggtc 172141 attggaaact ggggaacttg agtgcagaag aggagagtgg aattccacgt gtagcggtga 172201 aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga ctctctggtc tgtaactgac 172261 gctgaggagc gaaagcgtgg ggagcgaaca ggattagata ccctggtagt ccacgccgta 172321 aacgatgagt gctaagtgtt agggggtttc cgccccttag tgctgcagct aacgcattaa 172381 gcactccgcc tggggagtac ggtcgcaaga ctgaaactca aaggaattga cgggggcccg 172441 cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg aagaacctta ccaggtcttg 172501 acatcctctg acaatcctag agataggact gtcttcgggg gcagagtgac aggtggtgca 172561 tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 172621 tgatcttagt tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga 172681 ggaaggtggg gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta 172741 caatggacag aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc 172801 tcagttcgga tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg 172861 atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga 172921 gagtttgtaa cacccgaagt cggtgaggta accttttagg agccagccgc cgaagtggga 172981 cagatgattg gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc 173041 tcctttctaa ggatattata cggaatataa gaccttgggt cttataaaca gaacgttccc 173101 tgtcttgttt agttttgaag gatcattcct tcgaaacgtg ttctttgaaa actagataac 173161 agtagacatc acattcaagt aatacaagat atcacatagt gattcttttt aacggttaag 173221 ttagaaaggg cgcacggtgg atgccttggc actaggagcc gatgaaggac gggacgaaca 173281 ccgatatgct tcggggagct gtaagcaagc tttgatccgg agatttccga atggggaaac 173341 ccaccactcg taatggagtg gtatccatat ctgaattcat aggatatgag aaggcagacc 173401 cggggaactg aaacatctaa gtacccggag gaagagaaag caaatgcgat tccctgagta 173461 gcggcgagcg aaacgggatt agcccaaacc aagaggcttg cctcttgggg ttgtaggaca 173521 ctctgtacgg agttacaaag gaacgaggta gatgaagagg tctggaaagg cccgccatag 173581 gaggtaacag ccctgtagtc aaaacttcgt tctctcctga gtggatcctg agtacggcgg 173641 aacacgtgaa attccgtcgg aatccgggag gaccatctcc caaggctaaa tactccctag 173701 tgaccgatag tgaaccagta ccgtgaggga aaggtgaaaa gcaccccgga aggggagtga 173761 aagagatcct gaaaccgtgt gcctacaagt agtcagagcc cgttaacggg tgatggcgtg 173821 ccttttgtag aatgaaccgg cgagttacga tctcgtgcaa ggttaagcag aagatgcgga 173881 gccgcagcga aagcgagtct gaatagggcg catgagtacg tggtcgtaga cccgaaacca 173941 ggtgatctac ccatgtccag ggtgaagttc aggtaacact gaatggaggc ccgaacccac 174001 gcacgttgaa aagtgcgggg atgaggtgtg ggtaggggtg aaatgccaat cgaacctgga 174061 gatagctggt tctctccgaa atagctttag ggctagcctc aaggtaagag tcttggaggt 174121 agagcactga ttggactagg ggcccctacc gggttaccga attcagtcaa actccgaatg 174181 ccaatgactt atccttggga gtcagactgc gagtgataag atccgtagtc gaaagggaaa 174241 cagcccagac cgccagctaa ggtcccaaag tatacgttaa gtggaaaagg atgtggagtt 174301 gcttagacaa ccaggatgtt ggcttagaag cagccaccat ttaaagagtg cgtaatagct 174361 cactggtcga gtgactctgc gccgaaaatg taccggggct aaacgtatca ccgaagctgc 174421 ggactgttct tcgaacagtg gtaggagagc gttctaaggg ctgtgaagcc agaccggaag 174481 gactggtgga gcgcttagaa gtgagaatgc cggtatgagt agcgaaagag gggtgagaat 174541 cccctccacc gaatgcctaa ggtttcctga ggaaggctcg tccgctcagg gttagtcggg 174601 acctaagccg aggccgaaag gcgtaggcga tggacaacag gttgatattc ctgtaccacc 174661 tcctcaccat ttgagcaatg gggggacgca ggaggatagg gtaagcgcgg tattggatat 174721 ccgcgtccaa gcagttaggc tgggaaatag ggaaatccgt ttcccataag gctgagctgt 174781 gatggcgagc gaaatatagt agcgaagttc ctgattccac actgccaaga aaagcctcta 174841 gcgaggtgag aggtgcccgt accgcaaacc gacacaggta ggcgaggaga gaatcctaag 174901 gtgatcgaga gaactctcgt taaggaactc ggcaaaatga ccccgtaact tcgggagaag 174961 gggtgctctg ttagggtgca agcccgagag agccgcagtg aataggccca ggcgactgtt 175021 tagcaaaaac acaggtctct gcgaagccgt aaggcgaagt ataggggctg acgcctgccc 175081 ggtgctggaa ggttaagagg agcgcttagc gtaagcgaag gtgcgaattg aagccccagt 175141 aaacggcggc cgtaactata acggtcctaa ggtagcgaaa ttccttgtcg ggtaagttcc 175201 gacccgcacg aaaggcgcaa cgatctgggc actgtctcaa cgagagactc ggtgaaatta 175261 tagtacctgt gaagatgcag gttacccgcg acaggacgga aagaccccgt ggagctttac 175321 tgcagcctga tattgaatgt tggtacagct tgtacaggat aggtaggagc cttggaaacc 175381 ggagcgccag cttcggtgga ggcatcggtg ggatactacc ctggctgtat tgaccttcta 175441 acccgccgcc cttatcgggc ggggagacag tgtcaggtgg gcagtttgac tggggcggtc 175501 gcctcctaaa aggtaacgga ggcgcccaaa ggttccctca gaatggttgg aaatcattcg 175561 cagagtgtaa aggcacaagg gagcttgact gcgagaccta caagtcgagc agggacgaaa 175621 gtcgggctta gtgatccggt ggttccgcat ggaagggcca tcgctcaacg gataaaagct 175681 accccgggga taacaggctt atctccccca agagtccaca tcgacgggga ggtttggcac 175741 ctcgatgtcg gctcatcgca tcctggggct gtagtcggtc ccaagggttg ggctgttcgc 175801 ccattaaagc ggtacgcgag ctgggttcag aacgtcgtga gacagttcgg tccctatccg 175861 tcgcgggcgc aggaaatttg agaggagctg tccttagtac gagaggaccg ggatggacgc 175921 accgctggtg taccagttgt tctgccaagg gcatcgctgg gtagctatgt gcggacggga 175981 taagtgctga aagcatctaa gcatgaagcc cccctcaaga tgagatttcc cattccgcaa 176041 ggaagtaaga tccctgaaag atgatcaggt tgataggtct gaggtggaag tgtggcgaca 176101 catggagctg acagatacta atcgatcgag gacttaacca tatttttgaa tgatgtcaca 176161 cctgttatct agttttgaga gaacactctc aatttgtttg gtggcgatag cgaagaggtc 176221 acacccgttc ccataccgaa cacggaagtt aagctcttca gcgccgatgg tagtcggggg 176281 tttccccctg tgagagtagg acgccgccaa gcaagcttaa acccagctca ttgagctggg 176341 ttttttgttt tatatctgtg ccgatttgct ttcgtcagta tccattttat caagcttctg 176401 ctttttaaag ttttctaata cttttgaatt ccaatacaat ccctagcatg atcaacatga 176461 gagtcataaa taatcaaaat gcagtttgta cgggagactc atccagactc catccgactg 176521 cgattggcag gatagagccg ccaatccatt ggcagcgaac agcatgcttg tcgtttgttc 176581 tgtttttcca tgataaaatt gattggtgac aataaaataa tggcgaacat gccggccata 176641 aataagtcct aagaaaaaac taagaataat ccctgcaaaa gctgttttat tgattgccaa 176701 aatacagagt taaatgaggc cgctcatatt tatcagcctg agataatgat gataggttat 176761 tttttcggaa accagctcgg gttgccaaat gagagaaaag atattactgt cattaaaacg 176821 attcttggtt tcatccggat atgataaaat gtctcagact atatttgagc catttttttc 176881 ttcagcaatc atcttgcgta attgataaaa atttattatg atactctttg tatgacaact 176941 ccttgcctca atacaatata ctcaacgttt ccccgttttc tccggtcgtt tttcttttca 177001 ttttctcccg taaaataaaa aaagctccca atacaataga tatggtgcgg atttattttt 177061 tactaaaaag gagtcgttat atttgaataa tagttttaca ttaaaacagc aatggttcgg 177121 gaatatccga aaagacattc ttgctggcat tttagttgcg ttagcgttaa tacctgaagc 177181 gattggcttt tctattatag ccggtgtgga tccgatggtc ggtctttatg cgtcattttg 177241 catagccatt attatttcta tttttggtgg cagacctggc atgatttcag ctgcgacagg 177301 ctcaatggca gtcgttatgg tgtcgctggt tgctgatcat gggcttcagt atttatttgc 177361 ggctacgatt ttgacaggca ttattcaggt gattttaggt atcagtaaaa ttgcaagatt 177421 aatgaaattc atcccgcgtt ctgtgatgat cgggtttgtg aatgcgctgg cgatccttat 177481 cttctctgcg cagcttcccc agtttgaagg tgcttcttgg agcatgtatg cgatgcttgc 177541 cgggtcgttg gttattattt atgtgctgcc aaggtttacg actgctgttc cgtctccgct 177601 tgtggcgatt attgtgatga caattattgc ggtcactttc catgtggatg tgcggacggt 177661 tggtgatatg ggcaatattt ctagttcatt gcctcatttc ttaatccctg atgttccgtt 177721 tacctttgaa acactgcaaa ttatttttcc ttattcaatt gctttagcgt ttgtcgggtt 177781 gcttgaatct ttgctgacag cacagattat tgatgaaatg acggatacgg atagtgataa 177841 aaataaagag agccgcggac agggaattgc gaatatcgtg actggattct ttggcggaat 177901 ggcaggctgc gctatgatcg gacaatctgt cattaataca aaagcgggcg gtcgcggacg 177961 tttgtcagca tttgttgccg gtgcttttct gatgttttta attgcggtgt taagtcatgt 178021 cgtggtgaaa atcccaatgg cggcgttagt agctgtaatg gttatggtgt ctgtcggcac 178081 ttttgattgg tcttctttaa aaggtctcaa aaaagcgccg ctcacggact cgattgtcat 178141 ggttgtgact gtggttacgg ttgttgtgac ggatgactta tctaagggtg tatttgtcgg 178201 tgttctttta agtgccgtgt tctttgtagc aaaaatctcg aagctgaaaa tcgtttctca 178261 tgcagaggat caaaagctta gaacgtatca agtgaagggg caaatctttt ttgcgtcagt 178321 gactgatctt acgaatgcgt ttatatatca agaggatatt gagcgggttg tgattgactt 178381 aactgaagct cacgtatggg acgattctgg tgcggccgca cttgataaga ttgttgcgaa 178441 gtttaaggaa caaggcattg aagctgagtt aaaaggtttg aataaagcga gtaaatctct 178501 aatgaaacag atggcataaa atagagaagc ccagatgaat gagatctggg cttttttata 178561 taacatacac ttaagcagca ttgatataat agagagaaga gaaattttaa ataggggact 178621 tgcatatgat gcttcagaag ctgaaccgtg tattggggag agtgatgccg ctgttaacgc 178681 cgactagtgt ggtgctgggc gtgctgctgt ctcagttttt aaatgggtat gaatgggctg 178741 tgccttggat ctttgctttt attacgtttg caggcagttt gagcgcgaac tttcaatctt 178801 tgagacatgc attgtctcat cctctcccta tgattcttgc actattcgtt cttcatattt 178861 tcatgccgct ttttgcttgg ggcagcggcc atcttatatt taaaggtgat cctttgacga 178921 ttaccggttt aacattggct gttgtgattc ctacggggat tacaagcttg atttgggcag 178981 cgatgtacaa agggaatgtc ggtttgacac tttcgattat tttagttgat actgtgctgt 179041 caccgctaat cgtaccgctg agtctttcat tgctggccgg cgctcaggtt cacatggatg 179101 tgtggggaat gatgaaaggt ctgattgtaa tggtcgtgat tccttctttt ttgggcatgc 179161 tgtttaatca gatgtcatct ccagaaagaa ctgcgtttgt gagcagtgcg ctgtcgcctt 179221 tttcaaagct ttgcttgatg gcagtgattg cgattaacag ttcagcgatt gctccttatt 179281 tcaaatccat tgatttgaga tttgcaggaa tagctgtaac ggtattcttt atcgcgttaa 179341 caggttatgc cgctgcttgg ctgatcggaa aaatgatgaa aaggcggcaa gaggaaatag 179401 tctctcttat atttacggga ggcatgagga atattagtgc cggcgcagtt cttgccgtta 179461 cgttcttccc gtctcaggtt gccgttcctg ttgtgatcgg catgctgttt cagcagatat 179521 tggctgcttt gtttggctat atgctgaatc gttttgaatt aaaaccaatg ttgcagaagg 179581 cataaaaaaa ccgctcatag ggttgagcgg ttttttccgt atagccattc gagcgcgttg 179641 atgaactgtt tgcagaaata cttgtggtgg tgcaccgctc ctttttcaat tgaaagacac 179701 aactggtctt cagtgaagcc tttttctttt agactttgat gaacttgctt tgtttttttc 179761 agcatatgtc gctgaatgga ttgtttttca cggccttctt cactcccgat agacatgaaa 179821 acacgtgcag tgccgggctt taaagaagat atatgaatgg tttccgctgc gttctcgtac 179881 cagtatgaac ctgatataga gcctattttc ccgaacattg acggatattt taatatggcg 179941 aacattgaga tgaggccgcc taatgaggca ccgatcattc ctcttgactg cggttccctg 180001 gtgacgttcc agttttcttc gattagcgga atgaactggt tcgttatatc agacagatag 180061 tgatatccca ttccgccgaa gtccgtgaac cgatcactga gtgatgcagc cggccatggg 180121 gtgtattcat caagccggtt ttcgggttcg ataccgatca gcacgagttc agggagcctt 180181 tgctgttgaa aggcgctttc tagtaattcg atttggtttt ggaacaaaga actgccatcc 180241 tgcacgtaaa cagcaggaaa tcccccgctg tctgtgctgt aggaaggagg gaggtacagc 180301 gtgaacctcc tgttgccggc tttgtgttct gaaagagatc ctttcaagca ttctccccct 180361 ttttttgctt gaaaagcaga tataagaaat aaggaactcc gaggatcgcc aaaatgatgc 180421 ctgcgggcac ttctgcgggc tgaaaaaaca gttttccggc aaagtctgcg cttatcacaa 180481 gaagcatccc gattaaaccg ctcagtggca ggatatagcg atgttcgacg ccagccagtc 180541 tccgtgagat atggggagca attaagccga caaacgccat acttcccgct acggagacac 180601 aggcgctgat gattgctaca caggcaacga gaaggatggt tttttcttta tttgatgaaa 180661 taccgaggct tctgactgtg tcttcatcaa aacgaatggt gtcgagcagg cgggatttgc 180721 cgataagaat cggtataaac agcagcatcc atgggagtac agctgtaata tacgtccagt 180781 tggcagacca gatgcttccg tttttccaca ccatggccat ttgatagtct tgcgggtcca 180841 tttttaaaga taaaaacaaa gacagggcgc tgaatcctga attgatcgca atccctacca 180901 aaataattct tcctgaatct aaattgcctc tgtgccatgc aaatatgtaa atcaggatcg 180961 ccgcgatgag cccgcctatc aatccaaaga gcggcattcc catcgctgca gctatggatg 181021 tcacttcctt ctggccttgg aataagagca taaacgctac aatgccagct cctgcccctg 181081 cgttgattcc gagaattcca gggtcagcaa gcccgtttct cgtgatggcc tggataacag 181141 cgcctgcaat gccaagaccg agtccaataa tagcagccat gacaacccgc ggcagtctta 181201 aatcgaacag caaaatttca tactgcggat tcgggtcgat ttgaaaaaga gtggagagca 181261 gctcagcagg acgaacagaa aatgatccgc tcgttaagct gaaatagctg acaacaagaa 181321 tcaaagcgat gaacaatgca tattttttag ccattttgct cccctccttt tcgtttaatt 181381 aaataaagga agaaaggtac gccgataatg gatgttacga cctcaatcgg tgtttcaaac 181441 ggatagttga taaatctgct tgcgagatca cacagggtta aaaagattcc gcccaaaata 181501 caggaacacg gaatcagcct gctgtaatca gagccgacga gaaatctcgt gatatgcgga 181561 acaaccaacc cgacaaacgc aatttttccg gccagcgcta cggcactgcc ggttagaatg 181621 atgacggaaa gcatcgccat gattttaatg gtttttttct tttgccccag gcttttagaa 181681 atgtcgtccc ctaatgatac agcggttacc tttttgctga gagaaatggc cattataatg 181741 ccaatcagga aaaacggagc ggcaagcttc aggaaatctg gactcatttg atgaagtctg 181801 gcactgtacc agaaactgag atcctgagaa atttgaaaat aaatcgacat ggccgctgat 181861 aagctgctga gcagcatgct tgtgactgtg ccgatgatgg cgagctgcac gggggtaaat 181921 ccgtttggca tcatggcggc aaggccgaat actaacaccg ctcctaacgc tgagccgata 181981 aaagagtata tcatcatttc aatcgaagat gattgcggga gcagaaccat gcaaagcgta 182041 atgataaacg ctgaaccatc tgaaacaccc ataatggatg gcgaagctaa ataattgcgc 182101 gtaatgccct gcataagcgc tccagaaaca gcaagggctg cccctatgag cagagcgccg 182161 gcagcccttg gaatccggga atgccatata atttgatggt ctgtgtttcc cggatcgaaa 182221 tgaataagag atgtaaaaac aatatctgtg ctgagatgct ttgccccata aaggattgaa 182281 agcaaaagtg acagcgctat agcaaatgga gaagtaatca atatgatacg tgtccactgt 182341 tttgaataca tacaaaaacc tactctgaat tagttttgtg tcaatttttc agcagccgct 182401 ttcaggaaac ggactttgct ccaagctgtg ccgccttgtg cgagagggtc cactgagttg 182461 acatacacat ggtcttcttt gactgcttta aggcttttcc agattggatt tttctctaaa 182521 tcttttaagg catcaggttt gtctgcattt tcatcatcag aaaattggac gaaaatatgg 182581 tccgggttca tttcacttaa tttttctaat gaactcagct cttgcgcttt tgcagccttt 182641 acttcgttcg gcgccttaag gcctaaatca ccgtatagtg tggagttgaa atacacctgt 182701 tcagggtaaa tgtaaatgtt gccttgtctg attctgatga caagcgcttt tgaatctttc 182761 gctttatcgt tgatttttgt ttttatttct tttagatcct gttcatagtc tgcaataatt 182821 ttctttgctt ttttctcttt tccagtcagc tgggcaagaa gcatcatgtt ttccttccag 182881 tttgaagaga tatgagaaac tgggatcgtc gtgcctgctg tgctgatttt ttgcagcgtt 182941 ttttccggaa actttgttga agcaaggata acatctggct tcatttcaag aatcttttca 183001 atatttggct ccattttttc tccggttggt tcggctttat cagtgatgtc tttgaacata 183061 tcagggaatt tgccggagaa tgaaattgcg ccttgcggat gaacgtcaag caatttcgcg 183121 tcttccattg attcaacgct tcccgtaatg gcaattttgt ctgtcggtac agttacttca 183181 tatgttttat caaggtattc aattttcttc ttctcagatg ctgtgccgct tgccttgctg 183241 gcagttgatt catttttgct gccgcaagct gccgccgtca gcgcgagaag taagattaat 183301 aaggtaagag atatcttttt catctataga gcctcctgtt caattgataa ctattatcaa 183361 ttggaattat agagaatgaa cagatataac accatggaca aattcctgat ttatcatgga 183421 caatctccgg atagtaaaga aacagtttgc tgaacgatgc gttcgtgccc gcaagctgag 183481 tattcattcc acgggtcaag ggatagaaga taaacacggt tatctcgtac cgcgcttagg 183541 ttttgccatg cttctgtctg ctgtaattgc tggtagtaag ctatggtctc cggctcttta 183601 aaaagaaaaa gcatcataca gtcagcttgg taatttgcga tattttctaa cgaaatcgct 183661 tgttctgaag gtgtgtcagc cgttgttgcc gagctgaatc ctaaatcccc aaagaaaact 183721 tcgcggacac ttcggttatg agccagatag aagttttgct tatgcagcct caaaaagaga 183781 aaacgcagcc cttgaacgtg ctgaagtgtt tttttggcgg ccgttgtctg ctggtcataa 183841 tccgctagcc acttttctgc ttcggactcc tcctttaaaa atgaggcagt ttgcagaaag 183901 tgggttctcc agctttcttc tgaaggaagg tacatgactt ctgcgatgcg attcaggcga 183961 tcttgttctt ctggagaaat agaatccatg ctgacaatca catctggttc tgcctgtgat 184021 aacgtgtaca ggttttcttc ccacttttca ttaaaccggt atgcactgag ctggacgggt 184081 atatctgtcg aataatgctg atagtagtaa gacgtccatt tcggatgcag agcggccgca 184141 aaaggtatgt ggtgaagagg gatgagatgg cccattgtgc cccttccgta tgcggcgatt 184201 ttctttcggc gttttttcat atagcttgta ggtgaacagc ctgtatattt tttaaagatt 184261 ctgctgaaat aaaattcatc ttgataaccg gtttggtgtg cgatttcttt caatttgcag 184321 tttgattttg ccatgagccg ttttgccttt gtgattcgtg ttttcgtaat aaattctgtt 184381 acgctctgtc ctgtccattt tttaaagctt tcactgtagt gtttggcact gattcctgcc 184441 atttgcgaca gctgggcaag cgtgattttt gtatcggcat gggtttcgat atagtgtttt 184501 gttttttcga ttgctgaatg tgtatccgtt tgatcagata aactggcagt aaaaagatca 184561 taaatcaggc tttgtacttc aatcacacat tttagctgag aaagctgaga cgattcattc 184621 catagtgcgg caagctcttg aagccggact gcaagatttt cgatatgtga aacattcata 184681 agcttcagtt tggctaattc cgattctgtg cacggtgtga aaatatcttg cccggtttcc 184741 ttgatatagc ttagaagcct gattatacag gcatctatat gtccatcggc tgctggcgta 184801 aagccaaagg tctcgttagg cggacaaaca taaagtgtct ttttttgcag aggattggtg 184861 tttgttccga tcgaaatata gccgtttcct tttaaatgaa aaatcagcac gaatgaatcg 184921 gctaattgct gttctgagaa gagatcactt gtctttttta gatattcaat ttgtactggt 184981 tgataaatca ctgcattttg cacgagtaga ccaccttttc agaagctttc aattgataat 185041 cattttcaat aaaaattgta ccaaataaat gaaagttttc ctatataaag cgggtgggtt 185101 tttagcatga aaaaaaccct tacttatgtg taaaagtaag ggtctttcgt tcaataagaa 185161 tatgttacac gtgtaacata cgatgcttat gttctaataa atgagatact tttttcttgt 185221 tttgctgaat tgttggagtg ttttttcata gctgtttatg atgttctcaa ccgaagttcc 185281 attttcaatt tttgtcctga tccagccgtt gcctgccagt ttatcgaatg aacctgttga 185341 caggaactca aaatcctcag gatagagatc gtgtatggtt ttaatgactg aaagacccgt 185401 tttaacggct tcaaacttat ctctgtctgt cacatagagc tgcacaccgt ggcaaagcgt 185461 tccttgatgt ttagaaaacg tcggtgtgaa ggatgctgcc ctaaatgtaa cgcccggcaa 185521 atggaggctg tttaatgttt cttcaagttc tgtgcttttg ataaagggag ctccgatcaa 185581 ttcgaatggc tttgttgtcc ctcgcccttc ggatatattt gttccttcaa tcagcccggt 185641 tgcaggataa acaaatgtgc tttccaccgt cggcatgtta ggcgaaggga ggacgaaagg 185701 caatcgggta tcgtcaaaat ccatttttcg tttccagtgt ttcattttta ccactgtaag 185761 atcggcatca atactaaatt ctttgttgaa cagtgaagcc aattcgccta tcgtcatccc 185821 atgcttcaat ggaatgggat acaatccgac aaatgaggcg tattcaggtt ctaagattgg 185881 tccttcaata tgattcccgc cttgaggatt cggacggtcc agcaccataa atggaatgcc 185941 gttttcttta gcggcttcca ttgcgtatgc cattgtataa atgtacgtgt agaaacgggt 186001 cccgacatcc tgaatgtcaa acattagaat atcgacattt ttaagcattt ctggagtcgg 186061 ttttttcgtt tttccgtaga ggctgtatac gggaaccccg gttttttcgt caatgtaaga 186121 gcctacttcg tctccagcct gggcgtcacc gcggacgccg tgttcagggc cgaataaagc 186181 tgtcagtttg atatccgggt tctcgtaaag gatatcgaca ctgcttttta gagatgtgtt 186241 tactccggct ggattggtga tcagtccgat gcgttttccc ttgagctgtt ttttatagtc 186301 tggcaagagc gtgtctatcc cagtctggac tttaggtttt ttagctgttt gattctttga 186361 atcgggtgaa gcagaggcag cggttatcgt tccgaacatc atgagccctg tcagaaaagc 186421 gaatattgtt tttctcatgt gtccctcctt attaaagcgg tcttcccgtt ttgatattta 186481 atccgtagcc aagtgggtaa agggtgttcc ctggtttcgt gactgacgga atgtcaactg 186541 gaagtgtgcc tttaggtttt gcctggccga atatcgccat cactccggcc ggaatattag 186601 gttgaagata acggccattt gcgtatcctt taaagccata gactgcaatc agtgcttttg 186661 cttcttcgaa attggctgcg tcataggggt tgcgcaggct cattaagaca aatggtttgt 186721 tgtgctgcag tgcggctttc atgacagctc tcggaaacac ggtggcccat ttgcttgaat 186781 ctgatattgt gtcgtcgatg acaccgtcgt tgacgacagg gtcatttttg acgacatagg 186841 agccggtaat gatataatca gcctctttta cttgtttttc atgctcggtc ttaaatactt 186901 ggctggcaaa gttcattttg ctgagggata cgggtttgat tttctttcgc ttgatgagat 186961 cgtgaatggt ttgttcgatt gaagcagttt gttcttcgta aggtgccaca attaagattc 187021 ggctgccttt tttaggcttg aacggcaaag tgtgctgttc attttttaat acagttactg 187081 ctttttcagc taattttttc tctgctttca ggtgctgctt gcttcctacg atttttttgg 187141 ctttggctat tttttctttt gtactgtcgc tgtttcgcgc tggatacatg ccgcgtttta 187201 ttttcaggga aatgattctt tcaactgaat tgttgatttg ttgttcagga atatccccgt 187261 ttttcacggc ttctttcaaa gcttgaataa cacgtgcgaa tttctgttct tctttcaatg 187321 aagtgactga ggctggcatt aatgcaatat cgacaccagc ttttacggcc atgaccacag 187381 cctcttcctg tccgaaatga tctgcgattg ccttcatatt gagcgcatcg gtaacgatga 187441 ccccattaaa gcccatttcc tgacgaagaa gacctgtcat cacttttttt gaaagtgtag 187501 ctggaaccag aatgtccgat ccatcgagtt tgcttttgta agtggtgtca tcaaaggcgg 187561 gaaactgaac atgggctgtc atcaccatat cagcaccagc atcaattgct ttttgaaaag 187621 gataaagctc gacctcacga agccgttctt ggccatggga aacgagcggc agtccataat 187681 ggctgtcaac gtccgtgtct ccatgtcccg ggaaatgttt gagggcagac gcgatatcct 187741 gccgctgcaa ccctttcatc gtatataaac cgaggcgtga tgtcagttct cgattggagc 187801 tgaatgaccg tacgccgatt acaggattat caggattatt gttaatgtcc acgacagggc 187861 tgaaatctgt attgatgcct aaggcagaga gctcttttcc gatgatgctg ccggtctgat 187921 acgcattgat tctgcttctg gctgcgccca gcgccatatt ccctgggaaa ttagtgccct 187981 cccctaacct cgttacaatg ccgccttcct gatcaatact cagcatgagc gggatttttg 188041 gacttgcctt ttggtaatcg tctgtcagtt ggacagtttg ttttgttgtt tttacatttt 188101 ctgcaaaaag gatgatgcct ccgaattgat atttcttgac gaggctggcg acttcatcat 188161 tcatttttgt aagggcttgc ggagaggact cgccttcctt ttgccaattt ctaaaatcag 188221 gcatcagcat ctggccgagt ttttcatcta acgacatacg attgacaatc tgattggcat 188281 cgattgcacg tttggatgca gaggcttctg tctgtctggc cccgaaaaag catgaaagaa 188341 agagaacggc tgaaaggata agcggaaaga caggtctcat agaaacttcc tcctatcgtc 188401 taatcattca ctccatcgct tcataaatcg cggttatgac acttccataa ctgcctgttg 188461 gaaattggtc accttcaaag acgttcggat tttcttccgg atcaataact ggtgtatgct 188521 ttttatttgt taacaatgcg atgcctaaat tgtatgctgg atcaataatt gtaactgtcc 188581 ccgtccagcc ggtatgcccg taagcatttt cgctggcatg agggccaaac atccattcca 188641 tgcttttact tccgttccgc ctccagccaa gagcgaatgt cggatctgtt gctgaaggtg 188701 ctgtaaacag gtcggctgtt ttctgatcaa ataaagaaat gtttcggtat gaacctttgt 188761 ttaacatgac ttgcagcagt atggccatat catctgcatt tgagaacaat ccggcatgcc 188821 cagacacgcc gtccattgag taaaacgctt tttcgtcatg cacctctcct tgcagcgtgt 188881 ttgtgcggat gttagggaat tgaataacgc cgtcacgtgt attgcccatg cgttcagtag 188941 ctgcgaactg tttcggttta aagccctttt gcagcggatt gtacaaggta tgcttcagcc 189001 tgagcggttt gtagagctct tgctccgtgt agacatcaag cggtttgccg gtgagttttt 189061 cgacaataca tccgagtagc atatatccaa tgtcactgta tacgtgtttt gtcccggttt 189121 gataatcgag cggaattttc gtcaaatatt caatcgtttt gtcccgttct tgggaatagt 189181 acttgccggc tttttccggc gtgtaaaagt aaaagcttga tgggagccct gattggtgct 189241 ggaggacatc aatgacacgt atcttgtctt ttccttttat gaggtcaccc ggctgatcct 189301 tgaaacccgg caaatatgca gaaacttttt catagacgtc aagttttcct tggctgacta 189361 agcgctgcaa tgcaaaattt gttgcgtaca tttttgtatt tgaggctaag tcaaacatcg 189421 tgcgggtttt cattttggcc ggacggcgca gcagttctga tccttcgtac tttttactgt 189481 agccgtatgc tgcttttttt atgatgcgtc catccttcac caccacaaga acggcgcctg 189541 gaaatcctgc tgcaatatcc cgttctatca tctgatctac cttccttagc ttcttcgtcg 189601 agaattgtgc agtttctgca tttatgattt tcggctcaat caagttgcct gctgtttgtg 189661 cgaaggtttc atttggcgca aatatcgata gggttaaaat ggcactgaat atgaacagtg 189721 tctttgtttt cacaggctag cccctttctg tgcttctatc ccgtttacta tccctaaaac 189781 agaaacaatt taatcgaact gagaagccat ttcatcttta tatccgaatg cataggtcaa 189841 taaaaaaccg gccgcgtagg aaataaagag cccaacgata tacaggatga tttgcgaagg 189901 caggactaga aaagatagcg gcagtccgga gacaccaatc gcaatggtgg ctacttgaaa 189961 ataagcttga aaggcgccgc cgattccagc tcctaaacat gctgttaaaa acggacggcc 190021 aagcggcagc gtgactccga aaataagcgg ttcaccaatg ccgagcagtc ccgatggaag 190081 cccgccggcg attgctttcc tcagtgttgt ttttttcgtc ttcacgaaaa cggcaaaggc 190141 cgcgcctacc tgtcctgcac ctcccatagc caaaataggg agcagaggat cattgccaat 190201 tgaattgatc agttccatgt gcacaggcgt caagccttga tgcagtccgg ttacgacgag 190261 aggaaggaag gttgcgccca gaataaagcc cgcagcgatg ccgccgatgt ccaggatgga 190321 cagtaggccg gatgtaatag catcagaaat gaatccgcct aaaggcataa atacgacata 190381 cgttacgatt ccggtgatta acagtgaaac ggtgggtgtg acaatgatat caagtgattg 190441 aggaataaaa cggcgaataa attgttcggt gtaagcaatg aatatggctg cgaaaaggac 190501 gccgatcaga cctcccctgc ccgggagaag ctcttctcca aataaactga tttttgcgat 190561 ctccggattg ataatcaaga tcccggccaa agccccaagt gcgggtgtcc cgccaaattc 190621 tttcgaagcg ttaataccga cgagaatgcc gagataagtg aacagccctg atccgatgac 190681 tgtcaggata atcgcaattt gtgagtctgc agagagccag cctgcttgaa taattgcttt 190741 ggtaatccca gtaattaaac cggaagcgac tagagcggga ataagaggga taaaaatgct 190801 ggcaatttta cgtaagaaaa gtttaaaagg agtggcattt ttccgattga tatcggcttt 190861 ctttttggcc gctgcttctt tgacatcggc accttcttct gctgacacga gctttgagaa 190921 agcagctgta acatgattga caactcctgt gccgaggata atttgtaagg tttcagcttc 190981 aacgaccccc aatacgccgt caagctttct taaagcctga gcatccgctt tgctttcatc 191041 gtaaggcgta atgcgcaggc gtgtcatgca atgcgtatat gaagaaatat tggattttcc 191101 tccgcatagc tcaaggattt tctgtgcgag atgatggtag ttattttctt tgctcattaa 191161 aacccctccc cttcaagatg ccttatttta ttctcataga ttgtatggct gctctcgttt 191221 tatctatata accggttgtc gtttcatact gctcagccgc catgcctaaa aacaaaacat 191281 caattataaa aagctgggcg aggcgggaag aagtggctgc acttcgaatc aaggcttcat 191341 tggaatgggc tgtatacaaa gggacatcag ccagtgcgga gacggatgtc tgactgaatt 191401 gtgtgaggct gatcgttgtg atgccttttt ccttagccat ggcgaacagt tcaacgattt 191461 cctgtgtctc tcctgaaaac gaaatggcga atacgatgtc gtctttatct gcatttgcga 191521 ttaaagatgc cacaagatga gtgtctgtaa acgcggttgc ttgtttatga atgcgaagcc 191581 acttttgctg ggcgtccttg gcgacaatgc cggaagcccc gaggccgata aaatgcacgg 191641 tatgagcttt gagaagcaga gaaaccgctc gttcaagctc tttgtagtcc atcaggtctg 191701 aagtatcctg aatggcttga atggcattgc cggccgtttt ttcggaaatg gagggcagcg 191761 gctcgtgggg aacaatatcc cggtagccct gaaacgtagg ctttgccaga tcgcctgcta 191821 ctctcatttt taaatcttga aatcctttta aaccgagtga tttgcagagc ctgatgacgg 191881 cagcgtcact tgaattggct aaggcgctga tttcgttgac cgtgctttcg attgctttgt 191941 ggggatgggc taggatataa tctgcaagtt tgcgctcgga tggagggagc ttatgcttca 192001 ttgattggat gatcgctaaa ccgcctgtgg ccattctagt tctctcctta tcatggatgg 192061 taatgttcga ttgctttgtc aatgaaaccg tttgcttcat cgagtaatgt ctgtgcttgt 192121 ttctgatctg tgcttgtttt gagcatgacg attgctgttt tgacgtgatg atcggcttgt 192181 tccagagtgt atctggctgt gtcgtatgaa gcgtttgtaa ggctttggat gatgctgatg 192241 gcgcgttctt ttagtttttt gttgctgacg ttgacgtcta ccatcaagtt ttcgtaaacc 192301 ttgccgattt tgaccattac agcggtagat atcatgttta gaatcatttt atgagcggtt 192361 gcggctttca tacgtgttga tcctgtaatg gcctcaggtc cgacgacaac ctcaatgctg 192421 tgatccgcat ccttgctgat ggcggaattt tcattgcaag taagggcgat ggtgtgtgct 192481 ccgactttac gggcgtatct tagggcgcct gcggcgtagg gtgtgcggcc gcttgctgcg 192541 atggcaatga cggtgtcatt tgaagtgagc tgtatgtttc ttaaatcttc agctcctgct 192601 tcttcactgt cttcaatgcc ctctgctgcc tgtaaaaagg cttcggggcc tccagccatg 192661 attccgatga cctgatctgg gcttacgctg taggtgggag gacattcaac agcatccatg 192721 acgccgagtc tgccgcttgt gccggcgcct gtatatatga gccggcctcc attttgaaac 192781 gattcatatg cgcagtctac agctgttttg atgtcgggga gaacctcctg aacggctgca 192841 gcgactttca tatcttcgtt gttgatcatt ttaaggatgc cgagagtgtt tgctttgtgg 192901 atttcaactg tttgactatt gcgtgattcc gttgtaagac ggtgaaggtt taatggttct 192961 gacatgagga tgccccctgt tttaaaatga tatatctcaa tattcagtat attcatttct 193021 gttatgatat ttcaactatg tttttaaatt tttgaaattt tatttcactt aagactataa 193081 gaaatgatga aggatcaact gttctccaag cggcccgatt cttcgccgtc ctttatcaag 193141 gaacccgctt ttcatataaa ggtgttttgc gcgtatgttc agatgattga cggccaagat 193201 gatttcgtcg caccatggaa aatatccgct cacaaaagcg ggaagcaaaa gcatggcttt 193261 tttcgcatag ccttttccgt gatgcacagc ggttaaagac agggagctga gcagtaaagc 193321 aaatggattg ttagaatagg aagcaagcgt ttcttttgat gcatgtaaaa tgaaaaaacc 193381 gactggaagg tcgtctttta agatgacaac cgggtatcgg tcctgtatgc ccagagcctg 193441 agacagcacc tctttcggga gggaggtaaa gcgtttgtca tcgttggtga gcgtgaatga 193501 ttggagctcg ggcaagtgtt caggcttata gaaggataaa gaaatgtctt gagtcatggg 193561 gtggcctcct tacaatatgt cgttaagctc gttttccgaa atgacgcggt agcccgcttg 193621 ttttaacagt gcggcggtta ctccgctgcc ggtgattttt ttgccagaga atgtgccgtt 193681 atagataaaa ccgcttccgc aagatggact gttttctttt aatatgacgg cagaagcgtt 193741 gatttctttt gcgtaagcca atgttttcgc ggcgccttcc atatatagtt ctgtgacgtc 193801 ttctcctgaa gctgtcacga ttttcgctgt tccattgagg acatcctcgc cagtgcctcc 193861 tatgatttct gcgggttcgc gtggggtaga gaagccgccg agaagttcag ggcaagccat 193921 gactgctttc ttttcatcga ctagttttct gattttctcc gacgctgcgt gagagccgtt 193981 atatctgcat tcaatgcctc caaggcaaga actgactaga atcatattgg tttctcctct 194041 cttgctttgc ttgtctctat cataaaataa atggctttag ttgggaggct ttttcagtta 194101 aaaaaggagt taaaaagttt gaaaataaaa aatttaattt tcctctttac aaacaggggg 194161 tgacctgtat ataataactt ttgtcagctc gacgagaaca caacggcccg ttggtcaagc 194221 ggttaagaca ccgccctttc acggcggtaa cacgggttcg aatcccgtac gggtcaccat 194281 ttggaggatt agctcagctg ggagagcatc tgccttacaa gcagagggtc ggcggttcga 194341 gcccgtcatc ctccaccatc ttgccggtgt agctcaattg gtagagcaac tgacttgtaa 194401 tcagtaggtt gggggttcaa gtcctcttgc cggcactgtt ttttcaaaat tttatgtgga 194461 ggggtagcga agtggctaaa cgcggcggac tgtaaatccg ctccctcagg gttcggcagt 194521 tcgaatctgc ccccctccac cattattggg ctatagccaa gcggtaaggc aacggacttt 194581 gactccgtca tgcgttggtt cgaatccagc tagcccagtc acagacacct ttgatcaaaa 194641 ggtgtctttt ttcttttcgg aaaaatcatt ccaacttcta actgttcagt ctgtataata 194701 attttaaaaa tatgttaagg tagtttattc acgaattacc atctacaccc tgccaaaaat 194761 ttgataaact tattttataa aaaaattgaa accttttgaa acgaagctcg tatacataca 194821 gaccggtgaa ggcagaggtt agataaatat ggaaatgatg attaaaaaaa gaattaaaca 194881 agtcaaaaaa ggcgaccagg atgcatttgc ggacatcgta gatatttaca aagataaaat 194941 ttatcagctt tgctaccgta tgcttggcaa tgtgcatgag gcggaggata ttgcacagga 195001 agctttcatc agagcgtacg ttaatatcga cagttttgat attaaccgga aattttcaac 195061 ttggctttat cgaatcgcga ccaatttgac cattgaccgc attcgcaaaa agaagccgga 195121 ttattacctc gacgcagagg tggctggtac ggaaggcttg accatgtatt ctcaaatcgt 195181 cgcagatggt gttttgcctg aagatgcagt tgtatcgctg gagctctcaa acacgataca 195241 gcagaaaatt ttaaagcttc ctgacaaata cagaacagtc atcgtattaa agtatattga 195301 cgaactctca ttaattgaaa tcggggagat tctaaacatt cctgtgggga ctgtgaaaac 195361 gcggattcac agaggcagag aggctcttag aaaacaatta agggatcttt aagtggggtg 195421 atgaaatgag ctgtcctgaa caaattgtgc agcttatgca tatgcatctt gatggagata 195481 tccttccaaa agatgaacac gtattaaatg aacatctgga gacatgcgag aaatgcagaa 195541 agcattttta cgagatggag aaatccatag cgctcgtacg gagcacatcg catgtcgaag 195601 cccccgcgga ttttaccgct aatgtcatgg caaaattgcc taaggagaag aaaagagctt 195661 ctgtaaaaag atggttcaga acccatcccg ttatcgcagc tgctgcggta ttcatcattt 195721 tgatgggcgg gggttttttt aacagctggc ataatgacca caatttcagc gtgtccaagc 195781 agccgaatct tgtggttcat aaccatactg tgaccgtgcc agaaggtgag acggtcaaag 195841 gtgatgtcac tgtcaaaaac ggcaagctga ttattaaagg caaaatagac ggggatgtaa 195901 ccgtcgtaaa cggcgaaaag tatatggcct ctgctggaca agtcaccggt cagattgaag 195961 aaatcaatca gttattcgac tggacatggt acaagatgaa gtctgcgggg aaaagtgtac 196021 tcgatgcatt caatccgaac ggagaagagt aaagcgcgtt agccgctttg ctcttttttt 196081 gcgggctgag agggctggca catttcactt gctaaatcga aatgtggtat aatgggctcg 196141 ctatgtaaag tacatatgcg taacacgtaa aacacaaaat acgaaatgac tgaaatcttg 196201 gaggacgagg aaatggcttt tgaggatatc ccttttttgc agtacctcgg caatgccgtt 196261 gatattctcc ttgtttggta tgtgatatat aaattgatta tggtgatacg cggcacgaaa 196321 gcggttcagc tgttaaaagg aattgtagtc atcgtgcttg ttcgtatggc cagccaatat 196381 ttgggcctca gcacacttca atggctgatg gaccaagcga taacatgggg atttttagca 196441 attattatta tttttcagcc tgagctgaga agagcgcttg aacagctagg ccgcggccgc 196501 tttttttcga ggagcggcac gcctgttgaa gaagcgcagc agaaaacgat tgaggccatt 196561 acaaaagcaa tcaattatat ggcgaaacgc cgtataggcg ccctgctgac cattgagcgg 196621 gatactggaa tgggcgatta tattgagacc ggcataccac taaatgccaa agtcagctct 196681 gagctgctga tcaatatttt tattccaaac accccgcttc atgacggtgc ggtaattatg 196741 aaaaataatg aaattgccgc ggccgcctgt tatctgccgc tttctgagag cccgtttatt 196801 tcaaaagaac tgggcacgcg gcacagagca gctgtcggta tcagtgaagt aacagacagt 196861 ttgacgatta ttgtgtctga agagaccggc ggcgtcagtg tggcaaagaa cggcgacctt 196921 cacagagagc ttacagaaga agcgctgaaa gaaatgcttg aagccgagtt taagaaaaac 196981 accagagaca cttcttctaa ccgctggtat tggaggggca agaaaaatgg ataaattctt 197041 aaacaaccgc tgggctgtga aaattattgc tctgcttttc gcgctcttgc tttatgtggc 197101 ggttaacagc aaccaagcac cgactccaaa aaaaccgggt gaatctttct ttccgacatc 197161 aacaactgat gaagcaactc tgactgatat tccggttaaa gcgtattatg atgatgaaaa 197221 ttacgtcgtg acgggtgttc cgcaaacggt taatgtcacg ataaaaggct cgacaagcgc 197281 cgtgaaaaag gctcggcaga ccaaaaactt tgaaatatat gccgatatgg aacatttgaa 197341 aaccggcaca cataaggttg agcttaaggc caaaaacgtg tcggatgggc tgacaatctc 197401 aattaatccg tctgttacga cagtgaccat tcaggaacgg acgaccaaaa gttttcccgt 197461 agaagtggag tactacaaca aaagcaagat gaaaaaaggc tattctccgg agcagccgat 197521 tgtcagtccg aaaaatgtgc agattaccgg atcgaaaaat gtgatcgata atatttctct 197581 tgtaaaagct tcagtgaatt tggaaaacgc agatgaaacg attgaaaagg aagcgaaagt 197641 gactgtctat gataaagacg gaaacgcgct tcctgtcgac gtggagccct cggtcatcaa 197701 gattaccgtt ccggtgacaa gcccgagtaa aaaagtgccc tttaaaattg aacggacagg 197761 aagccttcct gacggtgtca gcatagcgaa tattgaatcc agccccagtg aggtaacggt 197821 ttacggctca caggatgtgt tggattctct tgaatttatt gacggcgtca gcctagattt 197881 aagtaaaatt aacaaggatt ccgatatcga ggcagatatt ccgcttcctg acggtgtcaa 197941 aaaaatctca ccgtcaaagg tgactttgca tatagaagtc gatagtgaag cggatcagaa 198001 gttcgagaat gtccctatca agactgtagg gctgagcagc tcacaaaaca ttgaatttct 198061 tgatcctgaa tcacaagcga tagatgtaac ggctaaaggc tctcccacga atataaataa 198121 actgaaaaaa tcagatattg aattgtatgt gaatgtttca gatttagagg acggggagca 198181 tagcgtgaag cttgaagtga acgggccaca gaatgtaact tggtccttgg ggcggaaaaa 198241 cgccaaaatc aagctgacgt ctaagaaaag caatacatca acgaatgata acagcagcaa 198301 tacatcaggg aaccaggaca cagataaaca aacaaatgat caaaagaaca atcagcaaga 198361 agatacaaag aacactgata aaaacaacaa cgatcaaaac caagacggaa ataaagatca 198421 aaaccaagat caggatgagg atgaatccac tgcgaattca caatcctcat cggaataaaa 198481 aaggagcgat tataaaatgg gcaagtattt tggaacagac ggtgtaagag gtgtcgccaa 198541 tagtgagctt acacctgagc tggcctttaa agtcggacgt ttcggcggtt atgtgctgac 198601 aaaagacaaa caacgtccaa aagtgctgat aggccgcgat acacgcatct ccggccatat 198661 gctggaggga gcccttgtcg ccggactttt atccattggc gcagaagtca tgcgcctggg 198721 tgtcatttct acaccaggtg tatcttattt gacaaaagcg atggatgcag aggcgggcgt 198781 catgatttcc gcttctcata acccagtgca ggataacggc atcaaattct ttgggggaga 198841 tggatttaag ctttctgatg aacaggaggc tgaaattgag cgcctgatgg acgaacctga 198901 ggataagctg ccaagacctg tcggagcaga ccttggactt gtaaacgatt attttgaagg 198961 cggacaaaaa tatctgcaat tcttaaaaca gacagctgat gaagatttca caggcattca 199021 tgtggcattg gactgtgcca atggcgcaac gtcatccttg gcgacacacc tgtttgctga 199081 tttagatgca gatgtttcta caatggggac ttccccgaac ggattaaaca ttaatgacgg 199141 cgtcggttcg actcatcccg aagcgctcag cgcgtttgtc aaagagaaaa acgcggatct 199201 cggtcttgcg ttcgacggtg acggcgaccg cctgattgct gtcgatgaaa aaggaaatat 199261 tgtagacggc gaccaaatca tgtacatatg ctcaaaacat ctgaaatcag agggccgttt 199321 aaaggatgat acagtggttt caaccgtgat gagcaacctc ggcttctata aggcgctcga 199381 aaaagaaggc atcaaaagcg tgcagacagc tgtcggcgac cgctacgtag tagaagcaat 199441 gaaaaaagac ggctacaacg tcggcggaga gcagtcagga catcttattt tccttgatta 199501 caacacgaca ggggacggat tattgtctgc tattatgctg atgaacactt taaaagcaac 199561 aggcaagccg ctgtcagagc ttgcagctga aatgcagaag ttcccgcagc tgttagtcaa 199621 tgtgagagtg actgataaat ataaagttga agaaaatgaa aaagtaaaag cagttatttc 199681 tgaagttgaa aaagaaatga acggcgacgg ccggattttg gtgcgccctt caggaactga 199741 accgctcgtc cgtgtcatgg ctgaagcgaa gacgaaagag ctgtgcgatg agtatgtcaa 199801 tcgcattgtt gaagtcgtcc ggtcagaaat gggattagag taacgaagtc tattatcaga 199861 gagtgaacaa gacaagcgag gtttacataa gataattgtg agacatacgg caaagttgct 199921 taaaaaacaa ttgaccgttt atgccacatg ttgtaaaatc aagcttgtct tgttcttatt 199981 ttctcaatag gaaaagaaga cgggattatt gctttaccta taattatagc gcccgaacta 200041 agcgcccgga aaaaggctta gttgacgagg atggaggtta tcgaattttc ggcggatgcc 200101 tcccggctga gtgtgcagat cacagccgta aggatttctt caaaccaagg gggtgactcc 200161 ttgaacaaag agaaatcaca tgatcttcca aaaaacatgt aggaggggac gattgaaagt 200221 ccccttgaaa tttgactttc ttcgtctcct tttacaatct taggaggaag aaaaatatgt 200281 gtggaatcgt aggttatatc ggtcagcttg atgcgaagga aattttatta aaagggttag 200341 agaagcttga gtatcgcggt tatgactctg ctggtattgc tgttgccaac gaacagggaa 200401 tccatgtgtt caaagaaaaa ggacgcattg cagatcttcg tgaagttgtg gatgccaatg 200461 tagaagcgaa agccggaatt gggcatactc gctgggcgac acacggcgaa ccaagctatc 200521 tgaacgctca cccgcatcaa agcgcactgg gccgctttac acttgttcac aacggcgtga 200581 tcgagaacta tgttcagctg aagcaagagt atttgcaaga tgtagagctc aaaagtgaca 200641 ccgatacaga agtagtcgtt caagtaatcg agcaattcgt caatggagga cttgagacag 200701 aagaagcgtt ccgcaaaaca cttacactgt taaaaggctc ttatgcaatt gctttattcg 200761 ataacgacaa cagagaaacg atttttgtag cgaaaaacaa aagccctcta ttagtaggtc 200821 ttggagatac attcaacgtc gtagcatctg atgcgatggc gatgcttcaa gtaaccaacg 200881 aatacgtaga gctgatggat aaagaaatgg ttatcgtcac tgatgaccaa gttgtcatca 200941 aaaaccttga tggtgacgtg attacacgtg cgtcttatat tgctgagctt gatgccagtg 201001 atatcgaaaa aggcacgtac cctcactaca tgttgaaaga aacggatgag cagcctgttg 201061 ttatgcgcaa aatcatccaa acgtatcaag atgaaaacgg caagctgtct gtgcctggcg 201121 atatcgctgc cgctgtagcg gaagcggacc gcatctatat cattggctgc ggaacaagct 201181 accatgcagg acttgtcggt aaacaatata ttgaaatgtg ggcaaacgtg ccggttgaag 201241 tgcatgtagc gagtgaattc tcctacaaca tgccgcttct gtctaagaaa ccgctcttca 201301 ttttcctttc tcaaagcgga gaaacagcag acagccgcgc ggtactcgtt caagtcaaag 201361 cgctcggaca caaagccctg acaatcacaa acgtacctgg atcaacgctt tctcgtgaag 201421 ctgactatac attgctgctt catgcaggcc ctgagatcgc tgttgcgtca acgaaagcat 201481 acactgcaca aatcgcagtt ctggcggttc ttgcttctgt ggctgctgac aaaaatggca 201541 tcaatatcgg atttgacctc gtcaaagaac tcggtatcgc tgcaaacgca atggaagctc 201601 tatgcgacca gaaagacgaa atggaaatga tcgctcgtga atacctgact gtatccagaa 201661 atgctttctt catcggacgc ggccttgact acttcgtatg tgtcgaaggc gcactgaagc 201721 tgaaagagat ttcttacatc caggcagaag gttttgccgg cggtgagcta aagcacggaa 201781 cgattgcctt gatcgaacaa ggaacaccag tattcgcact ggcaactcaa gagcatgtaa 201841 acctaagcat ccgcggaaac gtcaaagaag ttgctgctcg cggagcaaac acatgcatca 201901 tctcactgaa aggcctagac gatgcggatg acagattcgt attgccggaa gtaaacccag 201961 cgcttgctcc gttggtatct gttgttccat tgcagctgat cgcttactat gctgcactgc 202021 atcgcggctg tgatgtggat aaacctcgta accttgcgaa gagtgttact gtggagtaat 202081 aattaattaa cccctttgga taagaaggtc ttcacatgtg ctgctaggct ccaaatgtac 202141 acctttccgt aagggcaaag tcaaatgtga aaaaaaactg ttccaaagtt aatcagaaat 202201 ttattttcat attgtatcct tcggtatcaa gtgaaaggag catcatatga aaacattatg 202261 gaaagtcctc aaaattgttt ttgtcagctt ggctgctttg gttttgcttg tatccgtctc 202321 ggtatttatt tatcaccatt tccagctaaa taaggaggcg gcactgctga aaggtaaagg 202381 cacagtagtc gatgttgacg gtaaaaagat gaatgtgtat caagagggaa gcgggaagga 202441 tacgtttgtg tttatgtccg gttcgggtat tgctgcgcct gcttatgaaa tgaaggggct 202501 gtacagcaag ttttcaaaag aaaataagat tgctgttgta gatcgggcag gttatggata 202561 cagtgaagtg tctcacgatg acagagatat tgatacggta ttggaacaga cgaggaaagc 202621 gcttatgaaa agcggaaata agcctcctta tattttaatg cctcattcga tatccgggat 202681 tgaagcgatg tattgggcac agaaatatcc taaggaaatc aaggccatta ttgcgatgga 202741 tattggattg ccccagcagt acgtcacgta taaattgagc ggagttgacc gattgaaagt 202801 gagagggttc cacctgttaa cctcgattgg ttttcatcgg tttatacctt ccgctgtata 202861 taatcctgag gtgattcgac agtcgttttt aactgatgaa gaaaaagaaa tctataaagc 202921 cattaacttt aagcaatttt ttaatgcaga tatggagcat gagcttttac agtcttacca 202981 aaacggcagc aaatctgtga atctgcctgc gccaaaggaa actcccgtct tgattttaga 203041 tgcagtctct gaccaaaata gacattcaaa gtatgctata caaaaccgaa aagactatga 203101 agcgtttgcg gctcaattca atactgccga tataaaggaa ctgaggggaa cacacagtat 203161 ttatttatat cagcctgatc aaatatataa actgtccatg gagtttatga gaaaggttcg 203221 ctaggatgaa gggttatcgt attttaatcg ttgaggacga tgtgatgatt ggtgatttgc 203281 tgcaaaagat tttgcagcgc gagggatatc gtgtgatatg gaaaacagat ggagcggatg 203341 tgctttcggt gattcagaag gtggatttgg tcattatgga tgtgatgctg ccgggtgaag 203401 acgggtatca aatgtctgca aaaatcaaaa agctggggct gggcattccg gttatttttc 203461 tctcagcccg caatgacatg gacagcaagc ttcaaggttt gcagatcggc gaggattata 203521 tggtaaagcc ctttgatccg agagagctgc tattaagaat gcggaatatg cttgagcatc 203581 attatgggac ctttacgcaa atcaaacatt tgtatattga tgcggtaacg aaaaaagtgt 203641 tcaatgaaag cctgcatgat gaggtattat ttactgcgat tgagcggaaa attttctttt 203701 atttatatga aaatagagac agtatcctga caaaggaaca tttctttgaa tatctatggc 203761 agctcgaaga tagaaacccg aatattgtca atgtgcatat taaaaaaatt agagctaaaa 203821 tcaatgatca agcgggtgag atgattgaaa atatatatgg agaagggtat cggctgaata 203881 ccgttgtgaa gaaatgaagc tcaagacaaa atatcagttg ttattgttta cggccgtcat 203941 tagtgttccg atgctattgc tggcggtcag tgttttgatg tcggtgattt atgacagcat 204001 gtttaaaccg atgaatcatg gtatgccctt tcacaggtcg tttgcatacc cggcaatgat 204061 cgttgtattt ttgatatcac tcttattgtt agctttttta ttttcaaagt cgattcattc 204121 tctgttgcat aaaatcaatc tattaaatca aaccattcgg catttggcga gtgatcaaag 204181 ggtgcccgat aaaattgaag tgaagcgtgc tgatgaaatc ggggaactga tcaagtcggt 204241 caatttgtta attgaacgga cgacatatcg tgaactggag ctgagacagc aggaggaaat 204301 caaaaaggag cttttgcaaa aactgcggca tgacattaat acacctttaa cggctctcag 204361 gctgcagtta ttttatttgg aagaccaatg tcatggtcag gctgtattcg aatcattgta 204421 tcagcaaatc gaatatatct cggaattaac taatgaattc aatctatatt ccgctgagac 204481 gctggaaagc tcttatattg taaatgaaga agtgcgtcta aacgagctat tagaaacagc 204541 ggtgaaaaag tgggattatt tatacagtat gagtgggatt gagctgcact ataagccggc 204601 agatcaagat gtgatatgga tgagcaacac gttatggatg gaaaggctgt ttgataatat 204661 ttttcaaaat acgttaaggc attcaaaagc taaaaagatg gaagtcacga ttgaacatgg 204721 cgatgttttt attcgtgatg acggtattgg atttgatcgg aatgagagca gtgagggact 204781 tgggttaaag attattgagg atacatgcag gctgcttgcg attacttatg agctgcatac 204841 aaatgataac ggaacggggt tcttgttttc aaaagagtga ccccgctgat gtttttcttt 204901 ctcctataaa atttatataa tagggagaaa gaaatggggt gaacatcata tgtttaaaaa 204961 aatcatcaaa acgattaagt acctctcaag cagttctagt gaccgatatc gcagacaccg 205021 gcattacagc agcagccggc gcagacatta tcgcagctac agcagcagtt cgggcaaaag 205081 aagacactac gaccgttatg gcggcagtca tcgttacaaa cgccggagct acagcagcag 205141 ttaatccaaa aaaagttctt gttccgcttt tgggacaagg gtttttttat gtgaccgatt 205201 gaatggcccg gtttagatcc tcgcgaatgg aagcggtgtg ctgatactct tcctcaatgc 205261 ccaataatct tttcagcagc aaggttactt cctttgtcag tgttaattcc tccagccaag 205321 tgccgttttt cttctttttt cctttatatt gagagtacag caagaataac agcgtttctc 205381 cgagatcgaa gaagtcatcc tgttttcgta cctttatttc ctccatttct tcaggagtca 205441 attgtttggc aaggccgaaa tcgatgaggc agagcctgcc atcattgatg atgatattag 205501 gcgttctgat gtcgctgtgg aagataaggc gatcatgcag gtattctata atctcaagca 205561 gctgcgaaat cagttgtaac gccataagct ctgtgaacgg ctgttttcga aaaaataata 205621 attcttctat attctctccc tcaatgaact gcatgacata ataagcctgt ccgtctatga 205681 tgaattcatc tatgaagccc ggaatttgcg ggtggtgaat gtttttgagc agttttattt 205741 cctgctggaa tcggactttc tctttttcct ttttggcttt tgtcggccga agctgtttta 205801 agacataagg tgtttgagct aggatatcgg tgcacaaata aaccaaaccg tagcctccca 205861 taccgaggca ctcttcgatt ttgtattgat gatttaagat aacgccgttc tttagagggc 205921 ggtcaaatag cagttttttt agaagtttta atgccatgtc tgcacttccc ttggttgtac 205981 tgactatagt ttaccttcta gacggagaat aaaaaagagc cggataaccg gctcggtata 206041 agttaaaact gctttgtcac gtcgtattca taatctattt ttgcttttac gttgctcatc 206101 gtcgatctgg ctgtcgctaa tgtattatat ttaaaactcc atacctttgc cacactgagt 206161 tgatccgaca aagagatatc ataagaccct gaagtcgagc tgtttacaag ggcacggctc 206221 cattcgttat tttcgcttgt catgatcaga tggcgtgtat ttccctggct tggtgtttga 206281 gtggcggttg tttgaactct ggttacaatg gcatcacgcg gtatcccaga ttggtttgtt 206341 aaatcaacct tgatcacgct ggagtcagaa cctgaggggc taaggcttgt atttccttta 206401 ttttcagcaa cgccgctgaa ttggaacgtt ccgctgcctg atttgattcg gtcttcaatt 206461 gaaagcgtaa agtacatgtt tccagtatag gtgcctcgtg acactttcac atagaaggta 206521 tccgtcgtgt tttgggcgtc tgcatttgca taaataaaag aagaaaacgt attagggtta 206581 ataacttctg tcccttgaga aacaggtatt ctgttcttgt cataaatttc aattttcatc 206641 cctgtatacg cgctctggta tgtactcctc atgtatactt tttctccctt attagccgta 206701 aaagtgaaat aggcttcatc ttgaccagct tccagtattg ttgtatcgat atttttatat 206761 ttccaataac cgatcggcat tgcggtatca aatgaattgt ttcctgtgat agcagtgact 206821 ccgacagctg atgccgaata cgtaaaggta gataagacag aaagcataac agcgaattga 206881 ataagccatt ttttcaccat gcaaacaacc tccttttatt tccatcatac ataataacga 206941 tttaggtgta aataaatgtt ttttgaggtt aatatataca ttatattcgc cgataaaaaa 207001 gaataagaga gaatactcgg gagggaattc aatgcgtctg aatcggcaat ttatccgcac 207061 tcagctgatt gcacagaaca tattgagcaa gaatgcgcct gccaaacggg agaatgcgac 207121 tgaaaatcca gcggcagttc tggaaaaggc atatagcagg cttaagtcac aatcttcaac 207181 tgggggaatc aatcagttca attattctaa aaccagcgtg tcgggaaaca gcgggacgtt 207241 cagcaaagtg tatcaatcag cgaatgatcg aacagtgaca gacacagggg aagaaacagt 207301 gattcaatcc caaaacccct atgaatctga gagtgatatc agaatcaaaa tactagatga 207361 aaaatacagc aggatgaatg cgattaataa aacaaagtct gatccattag gctatattaa 207421 ggataagtac caaaattcaa agtctcctta tttcagaagt gatctgtcag ctgcagaaag 207481 acaggccgct tacgataatg aaacagaatg gttattcaaa gggaaggcgc aaaactataa 207541 ccttcaggat gctgtgtttc ggaatgtcac atttcatggg gaagtggaag ctgagaatga 207601 aaaggtgtat cagcggggac aggttaacca gcagctgcaa gtactgttga atcgaaacca 207661 tattcatatt ccagagggga cagagctgac gtttacaatc acaccgattg actatcaggt 207721 gcgggtaagc gggacagacg atcaggatct gatcaagcaa attgagcaag tgctgcaatc 207781 tggagacaac agcaaagaac tatttttaca catcatgaaa agtcaaagca gtgattcagc 207841 acaattttcc gaagaggcct ataaaaagta tcaggcagct cgtgagatgt atgaagttac 207901 aggctaccat ttgaaggatt tagaagtgat tgatgggcgg tacgtcacgc ctgagggacg 207961 tgacttaatg gatgtatata aggaagagct tgaaaaagat ccagtgcaga aacaaacggc 208021 ttcttatgct atatcttact atcgttcaga gctcagtaaa atcgcggaag ccgggtataa 208081 tgccattccg gatttcatcc tatcaattga ttacagcaat ggatctctga gagatgtggg 208141 acaaagcaag agctatggga ccggagatac cgggtggctt gaagcattaa agcgtcaaac 208201 gggtgtgaat tattaggtaa gctgttcatg taggacagct tattttttat gagaatctaa 208261 ggggtgaatt aatcccaata ttcaaataat tttattattt ttatataaaa gattttaaaa 208321 gaagtgaacg attcaaaact ctgaacaaag gtgtttacct gaaaaaaaca attgtatttt 208381 ccagagaaat ttattatgat gaaataagta atttaggaga ttatataaca attttaagtt 208441 tgaattttct gattgttatc actgattcat gtgaaggcaa gcaggtctgc tgttttctca 208501 tttatgagta ttttgttagg aggaggaaga ggagtggcaa ataaagaatt aaagaggggc 208561 ctgggcgcgc gccatattca gatgatcgcc ttgggcggta caatcggtgt tggcttgttt 208621 atgggttctg ccagcacgat ttcatggact ggcccatctg tccttctggc ttatgcaata 208681 tgcggaattt ttatcttttt tattatgcgt gcgatgggtg aaatgctgta tgtcgagccg 208741 agcacaggtt cttttgcgac gttcggccat caatatattc atccgatggc aggttatata 208801 acagcatgga gcaactggtt ccagtggatt atcgtcggca tgtcagaaat tatcgctgtc 208861 ggttcttata cgaagtattg gttcccggat ttgcctgctt ggatacctgg tatcgtggca 208921 atggtgattc ttggtgcggc gaatttaatt tctgttaagt cgtttgggga atttgagttt 208981 tggtttgcga tgattaaaat cgtgacgatt atcttgatga ttattgcggg aatcggaatt 209041 attttcttcg gttttggcaa tggcggagat gcgatcggtt tgtcgaacct gtggtctcac 209101 gggggcttct ttgcaggagg tttctcaggt ttcttctttg cactgtctct tgtcattgca 209161 gcctatcaag gagttgagct gatcgggatt acagcgggtg aagcgaagga cccgcaaaac 209221 acgctaagaa atgcgattca aagtattatc tggcgtattt tgattttcta cattggcgct 209281 atttttgtga tcgtgacggt gtatccttgg gatgagctca actcactcgg aagtccgttt 209341 gtgtctacgt tctcgaaaat tggaattacg gcagcggccg gcattattaa ctttgtcgtg 209401 attactgcgg caatgtccgg ctgtaacagc ggtattttca gcgcgggccg catgctgtat 209461 acactgggtg tcaatggaca agcaccgaaa ttctttaaga agatttcacg caatggtgtg 209521 ccgctgtatg gcacaattgc ggtgctgatc ggtttggctg tcggcgttgt actgaactat 209581 atcgcgccgc cgaagatctt tgtctatgta tacagcgcaa gcgtgctccc agggatgatt 209641 ccttggttta tcattttgat cagccatatc ggattcagaa aagcgaaggg tgctgcatta 209701 gataaacatc cattcaaaat gccgtttgct ccttttacaa actatttgac gattgctttc 209761 ttgctgatgg ttctggttgg catgtggttt aacgatgata ctcgtatctc cctgattgta 209821 ggcgtgattt tcttagcgct tgtggtcatt agttattatg tgtttgggat tggcaaacgc 209881 acgcaggcca atttgacaaa aagcgaacaa gcagctgaat aacgataaaa aagagacatt 209941 cacggatgtc tcttttttta tttttcgcgt atggattttc cctattttag caagctatag 210001 ggtaaagata gcagaaggaa aggtgttcat aaaatggatg ttacactcgg ttatttgcgc 210061 gaatcacttt cgaatcatct agaaaatgaa gtctgccagc gtatttgcaa gaagatgctg 210121 gcgaagcgtt atgcaaatga agaggaattt gtaaaagact tagatgataa tgaaatgtct 210181 tttttgaacc atgtattaga aaaagaaatt aagtatgccc agaatgaaca ggatcaaaaa 210241 cgggccaagg aattaaacga ggtgtatgaa ttactgcttt gagaaaggcg ggtaagaaat 210301 gggagcaatt gaacgaagcg gatatacatt tcagccggag tttagcgttg tccgtcaaaa 210361 cggagccatc catgtgtacc atcaaggaga atttgtggaa gaaatcgaat ttgaatttaa 210421 cggggaatat cccgatcatg atttgattga agagcttgtg aatcattatt gttttgagca 210481 tgagatttag agccctgccg tgcagggctc ttttatttag gatgtaatca ggccatactt 210541 tttcaggata tccacggtga tgtttttggc ttttgtgccg gaatcatcga cattggtgac 210601 aaagacataa gagccatgct ctgttttgat gaatccgaca aaccatccta atcccatatc 210661 agtcaggcgg gttccggttt tcccgtagag cgtgtaatga tcgccttcct cttgaatcat 210721 catgcgcttg acgattttca tcaccggctt gtcaaatgga agctcctctt tagccagttt 210781 ctccaaaaaa gtttcttgtt ccagcggaga tattgtgagc gagctttgca gccaaaactg 210841 gtcgattccc ccgctgatat cctcgttgcc gtaagataga gtatgaagcc atgttttcat 210901 tctttcctcg ccgatatctc tcgctaatgc ctgataatac cagattgcgg attcgcgcat 210961 ggccgagcca agcgtatggt cgcggttcca tgattcgaat tcacgcttga ccccgtccca 211021 tcgtttaaca tcgtattcat ctcttacagc tttgacctgc aaaccgatta aagcgttcac 211081 gactttaaag gtggattgcg gagtttgtct ttgatttgcc cgttttctgt tatagacaaa 211141 tgtctgatcc ttttgtaaat cgtgaagaat gaaggttcca tccgtatcct tgaattcatc 211201 atcgacattc attttgctga cattcaagtg tttttcatga gcagatgatg ctgcgtggac 211261 ggagaagccg ccgatccctg caatactcag cacaagcaca acatatatcc attttttcat 211321 tttgttctcc ccttcgtttt gattaactac cttttctctc tttcgtttgt tcttccttta 211381 aaaaataatc aaaaagcgct taaatttggt tttgcaaaca aatactgtta ctgggtttat 211441 agtcggaaga taacgtgaaa atagagggta aaaaggaagg cagggtaagc ggatgaatga 211501 gcagattcca catgacaaaa gtctcgataa cagtctgaca ctgctgaagg aagggtattt 211561 atttattaaa aacagaacag agcgctacaa ttcagatctg tttcaggccc gtttgttggg 211621 aaaaaacttt atttgcatga ctggcgctga ggcggcgaag gtgttttatg atacggatcg 211681 attccagcgg cagaacgctt tgcctaagcg ggtgcagaaa tcgctgtttg gtgttaatgc 211741 gattcaggga atggatggca gcgcgcatat ccatcggaag atgctttttc tgtcattgat 211801 gacaccgccg catcaaaaac gtttggctga gttgatgaca gaggagtgga aagcagcagt 211861 cacaagatgg gagaaggcag atgaggttgt gttatttgaa gaagcaaaag aaatcctgtg 211921 ccgggtagcg tgctattggg caggtgttcc gttgaaggaa acggaagtca aagagagagc 211981 ggatgacttc attgacatgg tcgacgcgtt cggtgctgtg ggaccgcggc attggaaagg 212041 aagaagagca aggccgcgtg cggaagagtg gattgaagtc atgattgaag atgctcgtgc 212101 cggcttgctg aaaacgactt ccggaacagc gctgcatgaa atggcttttc acacacaaga 212161 agatggaagc cagctggatt cccgcatggc agccattgag ctgattaatg tactgcggcc 212221 tattgtcgcc atttcttact ttctggtgtt ttcagctttg gcgcttcatg agcatccgaa 212281 gtataaggaa tggctgcggt ctggaaacag ccgggaaaga gaaatgtttg tgcaggaggt 212341 ccgcagatat tatccgttcg gcccgttttt aggggcgctt gtcaaaaaag attttgtatg 212401 gaataactgt gagtttaaga agggcacatc ggtgctgctt gatttatatg gaacgaacca 212461 cgaccctcgt ctatgggatc atcccgatga attccggccg gaacgatttg cggagcggga 212521 agaaaatctg tttgatatga ttcctcaagg cggggggcac gccgagaaag gccaccgctg 212581 tccaggggaa ggcattacaa ttgaagtcat gaaagcgagc ctggatttcc tcgtccatca 212641 gattgaatac gatgttccgg aacaatcact gcattacagt ctcgccagaa tgccatcatt 212701 gcctgaaagc ggcttcgtaa tgagcggaat cagacgaaaa agttaaatta aaaagctctc 212761 ttcctttatc gaagagagct ttttgattac ttcttttttt catcgtagta ttggacggga 212821 tacatggagc cttctgatac cattttgttg tcctcgatat cttgcgggtc cgggtggccg 212881 gctttatcaa ctgggaacgt ttccatgtct ggctgttttg ttattttcat cttcatgctg 212941 tgaatgaatt ctcttgcctt ttggcgattt gacgggtctt ttaatagata agaagtgatg 213001 ccgacagttg aaacagcgag acctgaaagt aacagctttt gtttcatggt gatactcctt 213061 tctattttaa gaatagtgtt tcctgtatca ttcccgtttt ggaaattgct aaacctgttg 213121 tgtttttatc attggaatta acagtaaatt ccatttaaga agaaactagt gacttcattc 213181 ctgtattgga aggtaatata cattgactta ttatagattt cagtcaaaat tcgataaata 213241 ttgacaaagt aaagtaatca gaataataat ataattagca agagaatgtc atcatacatg 213301 aaaggtgttt acgatatgaa tcaattgcat cgaagaatgg gaacgttttc cctcatgatg 213361 gtcgggctcg ggtcgatgat cggttcaggc tggctgttcg gggcttggcg tgcggctcaa 213421 atagcaggac cagctgctat tatttcatgg gttattggaa tggtcgtcat tttatttatt 213481 gctctttctt atagtgaact aggttctatg ttccctgaag cggggggaat ggtcaaatac 213541 acgcaatatt cacacggttc gtttatcggt tttattgcgg gctgggccaa ctggattgcg 213601 attgtgtccg tcattccggt tgaagcggtg gcctccgttc aatatatgag ttcttggcct 213661 tgggaatggg cgaaatggac aagcggtttg gtgaagaatg gaacgctgac tggggaagga 213721 ctagcgtttg cctctgtatt gcttctcatt tattttctgc tgaactactg gacagtcaat 213781 ctattttcga aagcgaattc attaattacg atttttaaaa ttattattcc gggtcttacg 213841 attggagctt tgctgtttgt cggattccac ggagaaaact ttactggcgg tcaaagcatt 213901 gcgccgaatg gctgggcaag tgtgctgacg gcggttgcca cttccggtat cgtttttgcg 213961 tttaatggtt tccaaagccc gattaatatg gcgggtgaag caaaaaatcc ggggaaatca 214021 atcccgattg cggttgttgg ctctcttttt gttgcgacag tgatttatgt cctgctgcag 214081 atcgccttca ttggagctgt gaatccttct gatattgctc acggctggag ccatctgaat 214141 tttaattctc cttttgctga tctggcgatt gcgctgaata ttaactggct tgttattgtg 214201 ttatatgcag atgcatttgt atcaccgtct ggaacgggga ttacgtatac ggcgacaacg 214261 tcccgaatga tttacggaat ggaaaaaaac aaatacatgc cgagtatatt cgggaagctt 214321 catccgattt acggcgttcc gcgacaagca atgttcttta acttgattgt ttcgttcatc 214381 tttttgttcc tgttcagagg atggggcgta ttagcggaaa ttatttctgt tgctacgtta 214441 atttcttata tcaccggccc gatcacagtg atgacattga gacggacggg gaaagacctg 214501 tacaggcctc ttcgtttaaa aggcttaaat gtgattgctc cgcttggatt tatctttgcg 214561 tcactggtgc tgtattgggc gcgctggccg ttaacaggac aggttctgtt tattatcctg 214621 atcggtcttc cgatttattt ctattatcag gcgaaggcga aatggaaagg gtttggccgg 214681 aactttaaag ccggcgtctg gatggtgttt tatctgctgg ccatgatggt tatttcttat 214741 ttgggcagtg ataaattcgg cggcctgaat gtcattcatt atggctggga tatggttctg 214801 attgcgatgg tatcccttgt attctatgtg tgggcgctga agagcggcta ccagacagaa 214861 tacttaaagg atgcgaaaga gataaattct cagctgctta atggacagtc agaagctgct 214921 gccggaaaag aataaaatat agaagaaaac cttgcgatag ttgtcgcaag gttttttgct 214981 tttaataacc cttttttact ttgtggaaaa gatcaggata gttggtgaac actcctgtta 215041 cgccccaatc aagcaggcga tgcatatcag cttcattatt gactgtgtaa ggatgaagca 215101 ggaggccgtg gctgcggatc atacggacgt tttcttgatt taaagcttta taatccgggc 215161 ccgcaccgac agcgtatgtt ttgatttctt ccagggcagc atctgtcatt gacgccattt 215221 gtttggcttc cagcaattga acggtcggca ggtttggctg taattgatgg acttttacca 215281 ggctttcttt gctgaacgat tgaatgatca cctggcctgg cttagaatgc tttcccagta 215341 atttatgttt ctgcaaagaa gcgatcagtt tttcttccat acctgggtag gtgtcaggcg 215401 attttgtttc aatgtagtag ttcgcgtgct ttccgaaacg gtctaatacc tcttctaatg 215461 taggaacttt aaggccgacg tactgcggct ttgctttttc cggataggct tcattaaacc 215521 aagaaccggc gtcaagcttc ttaatgtctg cgagcgtatg gtctttcacc caacccattc 215581 cgtttgtggt gcggtccagt ttttcgtcat gcatgacaat caattttccg tcttttgtca 215641 tttgcagatc caattcaata aaatcagctt tcattttctg agcggtttcg taagacagaa 215701 tcgtgtgctc aggcacatat ccagaagccc ctctgtgcgc gacggtcagg atacggtcag 215761 gtgacagcag gtttcctttt gacgctgccg acactggcgt taccataaat gagagtaagc 215821 ccagcgacag aacaaacaag gccagtattc tattttttct catgatttct cctccttata 215881 gataagcact acctgtcttt cataataaaa aacggatgta aacggcgtgt tggaaaacta 215941 ttaatctttt atgtgtcttt cttaaacatg ctctgcccgt tttcctgtat tccacgtcaa 216001 agccaagaag acgatggcaa gaatgcagga tgagatcagc atgataaagc cgccgttcca 216061 gttaaaacgg tccacgacaa agcccataat ggcgtttgcg aaggcggatc cgccgatgta 216121 tccgaaaaat ccggtcaaac cggctgcagt tccggctgct tttttcggtg ctaggtcaat 216181 tgcttgaagg ccgatcagca taacaggtcc gtagattaag aagccaatgc tgatcagggc 216241 gatattgtcc acgagcggat tgccggccgg attcagccag tacaccaata cggcaatgaa 216301 aacacccgcc ataaacaaaa cgcctgccgg tgcccggcgg cttttgaaga atcggtcact 216361 gatccagccg cacaagatcg ttcccggtat gcctgcgtat tcgtaaagaa aatacgacca 216421 gcgtgagtct tcaggagaaa agcctttggc ttctgttaag taagtaggcg cccagtcaac 216481 cacgccgtat cgcacgaaat aaacaaatac attggcaaaa gcgatgtacc aaagaaattt 216541 gttgttcagc acatattgaa aaagaatttc ttttgttgtt aattcttttt cctgattttt 216601 aaaagcgtgt tttggatagt cattccgata ctcttcaatt ggcgggagtc cgcaggattg 216661 aggcgtatca cgaaccaata aaacaattaa aaatgaaatg ataatggcga tgatggcagg 216721 gaagaaaaac acgcttttcc aagtgacgaa catcgcgatc ccaagagtga caagcggagc 216781 aagaataccg ccgcctatgt tatgggcgac attccagatc gacatttttg tgccgcgttc 216841 acttatggag aaccaatggg ccatcgtcct gccgcatggc ggccagccca ttccttgaaa 216901 ccatccgttg ataaacataa aaataaacat gatggtgacg ctcgaagtca cccaaggcat 216961 tgaaacgaat agaatattaa cgattgctga taaaaatagg cctgtcgcca gaaaatatct 217021 cggattacag cggtcagaca ccattcccat gatgaatttg ctgaagccgt acgcaatgga 217081 cacagcggcc agcaccaaac ccagttctgt tttcgaaaat ccctgttcct gcagataagg 217141 aatggcaaag gcaaagtttt tccgcagcag gtagtagcct gcgtagccaa tgaaaatacc 217201 aatgaatact tgcagtctga gccgtttgta tgccgcatcc atctttgaat catccagtct 217261 ctcaatatga ggagccggtt taaatatatt aagcattaat aattatcccc ctttgctgtt 217321 tgtgctggat gtgtggcgtg cctcctttcc cgaaaaacaa aaagagccag aaaacacccc 217381 ttgtcaaaag gggttggatt cctggctctc ctcatctcca tccaagctat taacttatca 217441 tgatagcgct ttcttaaatt atcatagtcc ggagcgaatg taaacgggta attttcaaat 217501 tgggccttag ggaagtgaat attatccttt tactaaatgc aattatattt ttttactagt 217561 aacataaaaa tctggaggga ggctgtttaa agatggatga attagatatc gcattcttta 217621 ttttaccgtt aggaattatg ctgctatcga ttgtcgggac ctgtatttgt aaaaacccgt 217681 atctgatgcc aatgcttagt ttggtgattt ctcttgtgct cacctttacc atttttaatc 217741 aatcattttt gggatgggct gttgtctata gcttggtttc tctggcttta tcctatatca 217801 cattgattgt ggtaaggaaa aggaaggaat caggaaatta aaaagacctc actttctaac 217861 atatcgttga ctaaagcaac tatatgtgat tataattgct ttagtcaacg atattagaaa 217921 gtgggaattg atttgaaaac aagagaatca tctgtcgggt taaaattcag aaagttcaat 217981 cgattttata caaacgtcct tggtttcctt aatgagcaca tttacgacag cccgttttcc 218041 ttaacagaaa cacggatttt atttgagatt tataatacgc ctaattgtac ggcaaaagct 218101 cttcaggata agctggggct tgaccgggga tatgtcagca ggattgtgaa gcagtttgaa 218161 aaagaagatt tgatttataa acagaggagc aaagatgacg cccgccacca ttacattttt 218221 gtcacagaaa caggaaaaac gatttataaa aagctggagg agaaagccaa cgaacaagta 218281 gaactgatgc tgaaggtaat caaccaaaag gagcagcaca agcttgccga ggcgatggca 218341 gagattgaag cgatcctttc acagtcgctt tctgccagag catcagagat atcgattaga 218401 gattattttc tttcggagga tcttcaactc cttattgaga aacaaagaca attttacgcg 218461 gaggctcacg gttgggatga cacgttttta gcttatcttc aggagacatt tgacgctgac 218521 atcgaaaaaa tatggattgc ggaaagcggc gggaaatttg ccggctctgt cgggttggtc 218581 aagcacgatg aaaagacagt ccagctcaga tggtttctgg ttgatgcgga ttttcggggc 218641 agggggcttg gcacgcaatt gctggagcat ctggttgcat actgccaaga catgaagttt 218701 gaccgcattt tcctttggac ggtgagcacg atggctgagg ctcgtccgct ctataaaaaa 218761 tttggattca ggataagtga agtaaaacaa gaagcgccat tatggggaca gcagctgaca 218821 gaagaacggt gggatttgga gctgtcatga aaagactgca ttatgcgtgg atcatcgtct 218881 ccgtcacctt tttgatctta ttggcggttc agggggtgcg gctgtcgttt ggtgcgtttg 218941 tggagccgtg ggaacggcag ttttcaatcg atagaagcac catctcgctg atttcgacgg 219001 tgagttttat tgtttatggc atatcacagc ctgtgatcgg tcggcttgtg gacaaatggg 219061 gtgcccgggc tgttttggca tggagtgcgt tactgacagg agtcagcatt ttcttaacat 219121 accttgtgac ttcgccttgg cagctgtttt tgctttacgg gctgggtgtc tcgcttggag 219181 tgggcggagc atcgaatgtg gcggcaagtg tattggtcgt caattggttc agcaaaaagc 219241 ggggactagc ctttgggatc atggaagcag gctttggcgc ggggcaaatg cttctcgttc 219301 ccggctcact catgttgatc cattggttta gctggaagct gacggttgtg gtgttgggac 219361 tgctgttaat cgtgattgtc tttccggctg cgctgctgat gctgcggaac aatccttcag 219421 aaaagaatac agagccgata ggcggactgg ctgcatcaga aaaagaaaca gcacccaaaa 219481 caacagctct ttcagtggcc gggatgtttc gtatgaggca attctggttc ttgatttttc 219541 cgtttttgat ctgtggattt acgaccgtgg ggctgatgga tacccatttg attccgtttt 219601 ctcatgatca tggcttttca acgacagtca cgagtgctgc tgtcagtctg ctagcaggct 219661 ttaatattgc tgggatcttg ctgtccggaa ttgtagcgga ccggtggagc agccggaaaa 219721 tcctgtgcat tttatatgcg gtgcgggcgc tgtcgatcgt gattcttatt tacagccacg 219781 agccctactt gcttttagcc tttgcgattc tgtttggatt agtggacttt gcaacggtag 219841 caccgactca aatgctcgcc acccagtact ttcaaaacta ctcgatcggc ctcatgattg 219901 gctggctgtc actcgcccat cagatcggat cggcactagg tgcgtatgtg cccggcgtca 219961 tctacacggt aacgggtgag tatacactgg ctttttattt gtcgattgga atgctcgtgc 220021 ttgcgagcgt aatgaatgtg atgctgaggg agccagctgc ggttacgcgt gacagtgcgg 220081 ctgtggtaga caagtgatga ggacaaaggg aaagcatctc tgatttcgag attattcaga 220141 gatgcttttt ttgtattttt gttctaatac gaagtcgatc ataccgacta tgcgggcgtt 220201 ttcggatttt tgtttgaagc gttcagaaat ttgaactttt cttgaaaatg gggaaacaat 220261 aaaaacccaa aaaaggccga tcaaggcaaa aaacatttgt acagctaatt ctattaattc 220321 attaaaacga gtgctgaaaa aatagaagta taacgttatt aatgtcacag tacatacgat 220381 tttggcaagt gtgtttgaat gtaagcaatg gttcactaaa gaataccttt aattgattca 220441 gcatgattga atcatatttg tttaggaaaa taagaagttc tttatcatct tttttatgtt 220501 ctaaaataaa gttgctgttt ctgtttcttt atatgtatgg tggtctacat tcaatatata 220561 catctcttaa agtataaaaa ttgagtattt cttagtaagg atgaaacaaa attacatgat 220621 ttttttgtta tatctttcag ttagaataaa atctataact cctctcattc gcaaatattc 220681 ggctctctgt gcaaagtgca gaacagtatg taattgtcct tttctagata tatttaaaag 220741 ctttatcaaa tcaataagga ttttcaagaa aataattaat aatagaaaga taaaaatgtg 220801 tggtatgtca atgtaattga tttgtcctga aaataaagaa gttgcataga caacaataat 220861 acttccgcaa aacatcaaac tcatataatg tggaagggaa aatggacgag ttgaaaaata 220921 tgcttttaat tggcttagca tagcattatc tcttgtatct aagtagccca aaagctcttt 220981 atcattttta ctaattgtaa gaacatgatt caatacagca ctaaaattca ttgaatcttc 221041 attatcagag gcagtatgtt tattagcctg tatgttttgt tgatccattt tatatttttt 221101 ataaagtatt gtattaatta acttgttttt ctcatagaat tcagatcgtt gattaaggga 221161 tgcttttcct ttgtttttat ttcctttttt tatgatttta gtataagtca taaaaataca 221221 aatgactgta aaaatagaaa acactgcagg tgaaatatct gaaagaatag tattggtgaa 221281 gacttctttt gcttggatga aaaggaaaga agctaaagtc atagatataa acatgcataa 221341 aactgctact ttcacaagaa actgaagcgg aagagaaggt tccgaataat agtgcttcaa 221401 ctggttgagt gtcagagaat cttggcgaaa aagataatct attatctcct gctgattttg 221461 catctgattg atatcatgag cgatgttttt tgttttttca aaaactattt gatcattttt 221521 catttttgat aaacctccaa aagacgatag ataaactaaa aaaactgcat gagcatattt 221581 taacttatgt tcatgcagtt ttgtattaaa gttagctagt ataataagca aaaatggcca 221641 gtaacatagc agataatgcg gtagcgactt tgactccttt attgttcgtt aaatcactgc 221701 ccatattccc aattagtaaa agtgcagcaa cacctacaac agggaataaa tattgatcat 221761 aagacggcca atctaacgct aattcactct cgggagacgt aactggtact cccttgtacg 221821 tctttatttt aaacgtaatc gtagtcgtta gtccagttgt gacattgtca ccgactggaa 221881 tatcaggtgt atagatttta atttgaatgt ttaaagattc agctgttgga tttacataaa 221941 cctccaaata accgttgcgt actgataagc tcagactatt taaaaggttt tgataagagt 222001 cgatttgtga cgcagtgaga gacgtttgag tgtcgcccaa taaacccgtg atataggcac 222061 ctggtttacc atttgtaatg gtaattgtgt ttggtgaacc ttcacttggt atggttgcca 222121 gaagtgaagt tgatagaata atatccaact caggtgatgt gaaaatggtt tctgtcgtat 222181 caaattcaaa catcgcgttt gccagacttg ttagattttc taaagctgga atggtagata 222241 aaatgtctgt cagtgtacgc agtcttgcat catataccgg atcagacggc ggatttacat 222301 tgcttgcacc tgagtctctt cctgaatacc cgtctttatc aatcccgatg cttccagagc 222361 cgcttccgat ggttccttca taaaattgat caaaggccca gttgtttggc atcggatagc 222421 cgagattgcc gctaaatcct gttgacatat ttgccacaaa actatacttt gtcagtcctg 222481 cttcagatgt acggatacaa atgtttcttg gtccgtaaac ccctatttca tacttaggtg 222541 cggttgaaaa tgtctgcatt tttgtaaatg ctgacttaat ctcttggaaa taaggaatga 222601 ttttatcggt cacttcataa tcgtatgcat caaaatcgac agcgaaataa atggtcgtgc 222661 ctgacggaaa acctaatctt ctagcagcag aagcggcact atatgcatct cttgtgcctt 222721 ggtctttgac aaaataagaa gattcatagc cgccgtcttg ataaattggg aaaaccttca 222781 atccggcatc aagaataact gcaagctctt tagatgtcag ggctttagat gtgaggccgc 222841 tgcttgtccg cacatttccg gtcaaatatc tgccaaccgt tttataaccg ttattccgca 222901 gtgtttgagc tttttctgcg gttataattg tagcagtgtc acaagcagaa gcggtgcgag 222961 ttgtgtctcc tgagcttgat aataaagctt taatggttgg catatctgca taacctgttt 223021 gcggcaggca catgaactct tgaaatgctt taacagctga aacaacaccc acaccatatt 223081 tgccgtcaaa ctcaccagga tcgaacgatt ttccgttaca atagagggcg tactgaacaa 223141 ttaagacaaa tcctgttctt gaatcgccgg gagttaaagt agggcacaaa cttgtggtgc 223201 cgtttccgaa aaatccattg gcaacacttg tgctcatgcc ttcttctttt tgcagggcat 223261 aaataagagc tttatttgta tcgcggccat acagtccgtc acaaggcatt aacccgatat 223321 agtcattgta gtctcgattt aagttttgtt gaatctggcg aattcttgaa tcacccccag 223381 acaccagctt aaaagcgctc atgtctaata aggctttcat aattaacgtg gtgacaatcc 223441 catcctgtgt tgtcagtccg gcagcttttt gaaattcttt taccgcattt tctgtttttt 223501 cgtaaaagac gcctgtaaaa ccgccgggat taaagccttt acaccataaa gccccttgta 223561 aaataaaatt catgttgctt ggttttgaat ctggagcttg gcgtttaaga ggcttaaata 223621 agcgctgtgt tgtcggcccg aagttatcgg ctggctctga gatacccaat tcaatttgaa 223681 gcgcccgagt cagaccgtag atcgtatccc acccagtttt cccgctttct tcaactgggt 223741 tatacccatg tttgccgctg tacgtatcgt tcagccattg ctgtgtgatt aagaccattt 223801 catcaaccat ttcgattcct cctttgttag attgcgttca tttataggtg gcaaacgtag 223861 gacaaaataa aaaaatggat gccgttaagc atccatttta catccgttct ccaacagctt 223921 cgctttcggt ttcagctctg aaatgtagag gcctaaaagt gtaagcgcgc ctcctagaag 223981 agcgatccat gtcatgtttt cgtgcagaat caggacagaa gcggcgatcg tgataaccgg 224041 gaccatgtaa atatacgcac tggatttgac ggctccgagc actccaactg aataattcca 224101 agtggcgaag cacagggcag aagcgccaat ccctaagaaa agcatgttga gtatatttga 224161 agcagatgaa aatcggctta ggtcaaaatg gaagtcgaac aaaaataaag cgggaaccat 224221 aaacaataaa ccatacaaaa atactctctg tgtcagctcg atgatgtggt attcgtaggc 224281 gcttaatttt ttcatgaata tcgagtatcc gccaaacacg agagcagccc cggctgccat 224341 gatgtctccg agcggattta gacgcagtac cacattgccg ttaaacgtaa tcaataaaag 224401 cccgatcagt gccgagataa atccaatcaa aaaagtcaga cgcaattttt cgccttcgag 224461 cagaaaatgg gccaaaaccg cagtgatcat cggtataatg gacacgatca tgccgacatt 224521 ggaggcgtat gtataggtga gagctatatt ttctaataga aagtataagg ttacgccaaa 224581 taaaccagct ccggcaaaca acagctcctg ccgccaattt ctgaacggaa tcatgttggg 224641 acggacgagg ataagagcga taaagcccat caaaaaccga taaaataata tttccattgg 224701 agagaagtca gccagcagaa cttttgtcga aataaaggtc gtcccccaaa tcagaatggt 224761 cacaatggct gcgatatgcc ccgaagtttc tctttgtatg ttcatctgtg aagctccttt 224821 tcaaaaatct tcatgtattg cttcggcgtc agccccacct gccgtttaaa aaacttcgtc 224881 atatgactct gatcgctgaa tcctgtctga aatgccgcat caatcggcct taccccttgt 224941 tcaaggagtt ttttggcttg attaatccgg attgtttcca tgtagctatt aggggtaatg 225001 cctttttgtt ttgtaaatga acgcaataaa tgatacttgc tccagcctgt taattcactc 225061 aaatcattga gtgtaacatt ttcggcataa tgctcttcta aaaattcaca aaccattttg 225121 acttcgtctg atggttctgg aacgctgcta aggaacgtga catctgaata atggcggatc 225181 agctcctcta atagatgaag aaacagctcc tccttacgca aagcttgttt ttcctcggat 225241 atcaaaatat gcaattcctg caggctggct gtcagctcat ggcggaataa cacatgctgg 225301 gagaaataag ggagatgccc ggagccagta atctctttca ccgccttctc catgatatcc 225361 ggcatgacat tgatacaccg ataatcaagc gtccggccgt caatctgttc acagctatgc 225421 gtgtcacggg ggttaaagag gagaagatca cctggattga tgatatattc ttgatcctga 225481 caggccagat accgttgccc tttttcaata aatccaatca cataataatc gtgaaagtgg 225541 ttcgggaact tctgcataat tcccttgaag cggtaggctt ctatatgaag gtgtgggtca 225601 agctgcagtg tgcgggtttc gttttgcatg ggatgcctcc tgtcggtgtg gtggtcttgg 225661 attaagtgta gcatgatttt gggggatttc ttgtatgatg ttgctgttta ggaatagaga 225721 aagcagaccg ttatttgtct gctttcgttt aagaatttaa aagattttaa ccctcaataa 225781 taattttatc ttttttaata aaaatttatt tttcaaatat ttcagttata atggtttgga 225841 acagatagga ggggcaaaga tgtatcaatc aaagaaggtt ttattgttag gttcaggtga 225901 attaggtaaa gaggtagtga ttgaagccca gcgtcttggg gtacagacgg tggcagttga 225961 cagttacgag catgctccgg cgatgcaggt cgcgcataac agttatgtcg ttgatatgct 226021 ggacccagag cagatcagaa ccatcattga gaaagaaaat ccggatttga ttgtgcctga 226081 ggttgaggcg attgcgacgg atgaattgct gaagcttgaa gaggaaggat ttcacgttat 226141 cccgaatgcc cgtgcggcca agctgacgat ggatcgggaa ggcatcagac gacttgcggc 226201 ggaaacgctt ggacttgcga cagctggcta tgaatttgcg aatacatatg atgaatttat 226261 acaagcggca gctcagatcg gttttccttg tgtcgttaaa ccattgatga gttcttctgg 226321 aaaaggccaa agtgtgtgcc gctctgaagc ggatttagag agctgctggg agacggcgat 226381 ggaaggcgga cgggtgaaaa acggccgcgt gatcgttgag gagtttatcc ctttcgaatc 226441 agaaatcaca ctcttaaccg tacgtgcggt taacggtacg gcattttgtg agccgatcgg 226501 tcatgtgcaa aaggacgggg attatatcga atcgtggcag ccgcatgata tgacagagca 226561 gcaaatagaa gaagcgaagc atattgcgaa aacgatcacg gatgagcttg gcggatacgg 226621 cctgtttggt gttgagctgt tccttgcgaa agatagggta tatttcagtg aggtatctcc 226681 tcgtccgcat gatacgggtc ttgtcacgct ggtgacgcaa aatttgtcag aatttgcgct 226741 gcatgtccgg gcgattctcg gctttccgat tacagaaatc acacagcttt ctcctggcgc 226801 cagcaggccc ctcaaagcgc cggaagaatt agcggattac actgttgaag gattggaaaa 226861 cgcactggca gtcccaaaga ctcaagtgcg cgtctttgga aagccgataa caaaagccgg 226921 acgtcgtatg gcagttgcgc tttctgctgc tgattcagtt gaaacggcaa gagagaatgc 226981 aaagaaagcg ttggaccagc taattttaaa atagagtttg aacaggtctt gtcatgggac 227041 aaggcctgtt tttttctttc tccgtaaaag ttttatcata agaatcagaa acctgattat 227101 aatgtaaaag tcttccatcg atacgggtgg ttgacactaa aggagggaga tgacaaaatg 227161 aaattagttc caagattcag aaaacaatgg ttcgcttact taacggtttt gtgtttggct 227221 ttggcagcag cggtttcttt tggcgtaccg gcaaaagcgg cagagaaccc gcaaacttct 227281 gtatcgaata ccggtaaaga agctgatgct acgaaaaacc aaacgtcaaa agcagatcag 227341 gtttccgccc cttatgaggg aaccggaaaa acaagtaaat cgttatacgg cggccaaacg 227401 gaactggaaa aaaacattca aaccttacag ccttcgagca ttatcggaac tgatgaacgc 227461 accagaatct ccagcacgac atcttttcca tatagagcaa ccgttcaact gtcaatcaag 227521 tatcccaaca cttcaagcac ttatggatgt accggatttt tagtcaatcc aaatacagtc 227581 gtcacggctg gacattgtgt gtacagccag gatcatggat gggcttcgac gataaccgcc 227641 gcgccgggcc gcaatggttc gtcatatccg tacggtactt attcaggcac gatgttttac 227701 tccgtcaaag gatggacgga aagcaaagac accaactatg attacggagc tattaaatta 227761 aacggttctc ctggaaacac ggttggctgg tacggctacc ggactacaaa cagcagcagt 227821 cccgtgggcc tttcctcgtc agtgacagga ttcccatgtg acaaaacctt tggcacgatg 227881 tggtctgata caaagccgat tcgctccgct gaaacgtata agctgaccta tacaaccgat 227941 acgtacggct gccaaagcgg ctcgcctgtt tatcgaaact acagtgatac agggcagaca 228001 gctattgcca ttcacacgaa cggaggatcg tcatataact tgggaacaag ggtgacgaac 228061 gatgtattca acaatattca atattgggca aatcaataaa tacagcaaac tagccatatt 228121 catgtctatt ttgtttttat gcgggtgcag ttcgcagacg cattcttctc aaaaagaaac 228181 gactattcct gtcactcttc atgtggagga tgctaagggg ctgccggtcg aaggggttca 228241 agtgacgatt gtcaaagcgc cctcttcaga tgaggagccg agtacagaga ttggcgagat 228301 actcggtaaa acagacaaaa acggagatat caaatgggat accggcagaa aaggcgatta 228361 ctcagtcgcg ttgacgaagg gtgaaacatc agtaacccat cacatctcgt taacagagga 228421 taaaaaagat catgccattc cattagtctt caaagaatag cagtttcctt gattttaagg 228481 gaactgcctt ttttatttat tgcaggaaac caaactatat actggaaatt tattatgtga 228541 gataataaga aataggtatt ttttcttacg agacaaaagg ggcgttatcc tttatatcaa 228601 tcaaacccgg aggaaaaaga agaagatgat acaagattca atgcagtttg ccgcggttga 228661 aagtggtctg cgcttttacc aggcatatga tcaaagcctt tctttgtggc cgattgagtc 228721 ggaagcattc tatgtttcta ctcgttttgg aaaaacacat atcattgcaa gtgggccaaa 228781 ggacgcacct tcgctcattt tgcttcacgg aggccttttc agctctgcga tgtggtatcc 228841 gaatatcgca gcgtggagca gtcaatttcg tacatatgcg gtcgatataa taggagacaa 228901 aaataaaagt ataccatcag cagccatgga aacgagagct gattttgcag aatggatgaa 228961 agatgtcttt gattctcttg gacttgagac ggcacatctg gccggccttt cgcttggcgg 229021 gtcccatatc gtgaatttct tactccgcgc gcctgaaaga gtagagcggg cggttgttat 229081 cagtcccgct gaagcgttta tttcatttca tccggatgtc tataaatacg ctgcagagct 229141 tacaggggca agaggagctg aatcatatat caagtggatc acaggcgaca gttatgatct 229201 gcatccttta ctgcaaagac aaattgtggc gggcgtggaa tggcaggatg agcaaaggag 229261 cctgaagccg acagaaaacg gctttccgta cgtgttcaca gaccaggaat tgaaatcaat 229321 acaagtcccg gtacttctga tgttcggtga gcacgaggct atgtaccatc agcaaatggc 229381 ctttgagcgg gcttcggtat tggtgccggg aattcaggct gaaatcgtaa agaacgccgg 229441 acatctgtta tctctggagc agccagagta cgtcaatcaa cgcgtcttgt cctttttatg 229501 cggggggata aaatagtaag gaacatgaaa agattggcat tcatttttca aaaggtaaca 229561 aatgttgtat aataatagaa tttgaatgct gctttttttg ggagcattct atgttatcat 229621 gcttattgga gaaaaatttt tcctgtaacg ctattcgatc actatcgtca aataatatag 229681 atggttttac aattggaggt ttggttacac tgtgaattac atcccctgta tgattacgat 229741 aggaaacttc atttgcggat tgctggcgat tcattccttg ctatatcaca acattcattc 229801 agcagtgctt tttattttta caggcatgtt ccttgatttc tttgacggga tggctgctcg 229861 taagctgaat gccgtttctg atatggggag agaactggat tcgtttgccg atctggttac 229921 gtttggggtg gctccttcta tgcttgctta cagtgtcgcg ttgtataccc tgccatttat 229981 cgggatctta tgcgcattga cgtacagcat ttgcggaatg cttcgcctct ctaaatttaa 230041 cattgaacaa agcaagctcc cgacgtttat cggtatgccg attccgtttg cgggcatgtg 230101 tctcgttatt ctaagcttca cctataaccc gatccttctg gcaatcggca cttgcggact 230161 ctcatatttg atggtgagta aaataaaatt ccctcatttt aaaaaacatg cggcagaaaa 230221 cctggagtct gggagatgga attagttcag cagctcatag cggattacgg ttatctcgct 230281 atttttttga tgctggtatt aggaattgta ggattgccga ttccagatga agtgatgatg 230341 accgttgttg gctatttcac gcataccgat gtattgaatt atgagctttc gatattgatt 230401 agttttgtcg gggctttgtt aggtatgctg atcagctaca tgattggcag aaaagccgga 230461 cgcccgttta tcgacaagta cggcaagtgg gtcggcttaa aagaaaaaag aatgatgaaa 230521 gtggaaaaat ggatgaagaa atacggtcca tattctctta ttttaggtta ttttattccc 230581 ggcgtcagac atgtgacgtg ctacttttcg gggatcggca aaatggatct gaaaacgtat 230641 gttgcgtttg ctgcaatcgg cgccttttta tggtgctttg tttttattac aatcggaagg 230701 gttataggga ttattcatgt ttaatacggc tgtaaagatt ctgtatcgat cattgataga 230761 gctgacgaat catcgtctgt catcctatct gattaaagga ttttgcgagt cgaaaatcag 230821 caaaccggtc attccgcttt tctcaaaaca ttttcggctg aattgggatg atgtggacgg 230881 tacggctgct gattacggat cgctgtccga attgttcatt cgacaaataa atctggagcg 230941 gcgccctgtg tcaaaagagg cgcatgcggt ggtcagccct gttgacggtg tggttcagac 231001 ggtaggaatc atcaacccga atcaaacctt tacggtgaag ggaaaagatt actcattcgc 231061 tgagctgacc ggctgtaaaa gcgcagacca tcaatacaac ggcggatatt tcgtcgtgct 231121 gtatttaagc ccgaggcatt atcaccgttt ccattctccg atcagctgca ggtatcaaaa 231181 gctggccgag ctcggaaatc gctcataccc ggtaaatcaa ctaggcttaa aatacgggaa 231241 agatgtgctg tcgaaaaatt atcggtttgt gtacgagctg aatagcggca gccgaaatgt 231301 cctgatgatt cctgtcggcg cgatgaatat taattctatc gtgcagacga atacccgtac 231361 tgaattggag atcggcgagg agctgggata cttttcattt ggctcaaccg tcattttggt 231421 ttttgaaaaa gacgcgttcc agccgtccgc ccatttagca gaaggccaag aagtccaagt 231481 cggagaactg ataggttacg aagaataaaa agaggagctt gcataaacgc agcgcctctt 231541 tttttgaaga aaggtgagat tcatggagaa acaaatcatc agctggatta cagattatca 231601 gaacaccgga gatgaagccg tcctgcggca agtgcgagaa gtgtgctggc cgatcgttga 231661 agcggttttg caagagaaag taatggatga tgaacaagcg aacaatttgc gcgaaaaagg 231721 aatcgagcgg tttccattca tcatcagcaa ataccaagcg gatgtgcagc ttccggttga 231781 gacattttta caaaatacgt atcggtttta ctttcatcag gtgatgagag aatccagcta 231841 aagcttcttt caacagagaa gctttttttt gttggcagga aaaggaaact ttttctatat 231901 ctatctcgta atgactagag aacctagcag aaaaggagag atagaattga aacgaatgat 231961 agtgagaatg accctgccgc tgctgatcgt ttgtctggcg ttttcttctt tttcagcctc 232021 agcccgtgct gcttctgaag aaaaatattg ggatcactgg attgaacgac atgcacagcc 232081 tctggatgct tccaatgctt caaacaaaga ccttcgattt ctaaaaaagg tgctgaaggg 232141 aaaacgaatc gttcagttag gagaaaccac acacggtgct ggcgaaatca atgccacaaa 232201 ggtcagaatg atcaaatacc tccacgaaga gctgggatac gatgtattgg cctttgaatc 232261 cggctttcct gatacaaatg catcctacct taatatggac caattaaccc ctaaaagcac 232321 gatgaaaaac tccatttacg ctgtatggca cacagaagat gtcgtcgaat tgtttgatta 232381 catgaaagag caaaaagaga aaggcgatcc gctgatcctt accggttttg atattcaaag 232441 catgaagaat tcattcaatg tagctgcgac tcaatgggta aaagcggtgg accctgagaa 232501 agcagagttg ctctcccaat cagaaaatga tttttcaaca ttagtgacag acagcaatac 232561 gtttgatgaa ttttcgcaaa agaaggaaaa gcttgtgaaa aactatcaga agctgatcaa 232621 gttcactaaa acacatgctt cagagctaaa agaaaacctt ccaaaagagc cgaaagctta 232681 tgagatgttt atgcattctc ttcagctgag aattgacgta atggaaacat atatgctgga 232741 agaaatgaaa gaaaaactag aggagtatcc ggagaatatt gaggattttt cattctttat 232801 gagagaccgc atgatggctg aacaatttca gtgggtagcc gacacccttt atccgaaaaa 232861 gaaaatcatt gtctggggcc acaattacca tctacgcaaa cagaatacga agatgataaa 232921 ggactgggta cagctaaacg gccctaacat gggtgattat ttgccggagc ggctgaaaaa 232981 acaaacatat acgattggca tttatgctta ctcaggtgcg agtcttgata gctccgataa 233041 taagactgtt aagccggtta caagcccgcc gccgtctggg agccttgaag ctttgctgaa 233101 agcggcggac cgaccggctg tttttgttga ttttctccat acaaaaaaca agaaaggcac 233161 ttcgtggatg tataccccgc ggactgcgct ctattggggg tacatggaag agcagatgat 233221 cctgaaggaa caatatgacg gtgtcatttg gctggagcat atcacgccct ctgtcattat 233281 caagtgagcg gtgtcccctg tggtaaacag gggattttta catatcgcaa aaataatcaa 233341 aacatataat ccgtgatcca ttattctaaa acagaaagga gattggagcg tgcaatgtat 233401 tatgaaaaag ctgtccagaa aacaatcaat tggattgaat cacatttaca tgagcaaata 233461 tcaaacgagg atattgttaa cgtttcaagc ttttcaaaat tccattttca tcggattttt 233521 caaaaagaag tcggcatgtc ggttgcttct tatattcggt taagacgtct tgcgaatgcg 233581 gcggcagctt tgctttatac agatcatcgt attatcgata ttgctttgta ttatcagttt 233641 gaatctcaag aagcatttac gaggacgttc aaaaagatgt atcacatgcc gccaggagca 233701 taccgaacat ttatgaaacg ctttacttca aaaaaggagg aatcttacat ggagaaaaaa 233761 atgaaaggct gggtattgag cgggagccat ccgttccaat tcgaaatggg gattgaccgg 233821 gaaaatgtac atcagggaaa agcttcaggg tatttaaagt caacgatggt tcaggatatc 233881 ggtgaatttg cgacgatgat gcagcaattc aaagcagatc gctatctagg aaaaaggctt 233941 cgtctatcaa gttttatcaa aacaaagggg gtgcagcatt ttgcctcact ttggatgcgg 234001 gttgacagtg ctgctgatga tgttctccaa tttgataata tgagcaacag acctattacc 234061 ggaacaacca attggaatca ttatgctatc gttttagatg tcccagaaaa tagcgctgtg 234121 atatcttttg gcgttcaatt atctgggccg ggtcaggtgt ggatggatca tgttgttttt 234181 gaagaggtag atgagagcgt tccttcaaca aaccttgaaa tgccgggaga acttttagat 234241 gaaccggtaa atttatcttt tgaagaggaa ctacaaaaat agttttcaga caactacttt 234301 tattagtgag ttaatggaaa atactatttg ttattaataa acccttgtgc tgcttaggtt 234361 tgtaagagct tggatatttt tatcagtctg ggcggatctg ttcatctttg cggcattttc 234421 ctgtatgata tagtaagagt gtgcatagca actaactata attgaacagg gtgtttaaaa 234481 catggaaaaa caatacagag tattacttta ctataaatat gttccgattg aagatccaga 234541 ggcgtttaga gagcagcatc tggctttttg taaggagctt ggtttgttag gccgtatcct 234601 tgtttcttct gaaggaatta acggtacggt atcaggtacg gttgaacaga ctgaaaaata 234661 tatggaaaca atgaaagctg atcctcgctt tgcggacatg gtatttaaaa ttgatgaagc 234721 agaaggccat gccttcaaaa aaatcttcgt ccgccataaa aaagagcttg taacgcttcg 234781 tcttgaagat gatgtcgatc cgaacgaaac aacaggccag catttgaagc ctgcagaatt 234841 ttatgagaag atgcaggatc caaacacaat tgtcatcgac gcgcgtaacg attacgagta 234901 tgaccttggc catttcagag gtgcggtccg tcctgacatc gaagccttcc gtgaattacc 234961 tgaatggatt gaagagcaca aagatatgct tgaaggcaaa aagattttaa cgtactgtac 235021 aggcggcgtg cgctgtgaaa agttctcagg atggctggtg aagcaaggct ttgaagatgt 235081 agctcagctt gatggcggaa tcgtgacata cggaaaagat ccagaggtgc aaggcaagct 235141 ttgggacggc cagtgctacg tatttgatga aagaatcagc gtgcctgtca accgtgtcga 235201 gcatgtgatt gtcggcaagg actactttac aggagaaccg tgtgagcgtt atgtgaactg 235261 cgcaaatcca tcttgcaata aaaaaatgat atgcacaccg gaaaatgagt ataaatatat 235321 gcgcagctgc agccacgaat gccgcacgaa cccaagaaac ctgtatgtga aagagcataa 235381 tatgacagaa gaagaagtaa acgcaagact ggcagcgatt gaaacagaag atcacgctgc 235441 tgctgaataa aaaaagaaca cctcgtattg aggtgttctt tttttctata tgctttcagt 235501 ttggctgttt gcggaaaccc attctttttg gcggaaggcc ttttcccatt ttgataccac 235561 gatacaggcg atcgcatgtc ccggtacgtt cacgcctgtt ctcgccatgt ccatgacgcg 235621 gtcaacaccc gcgataatgg caacgccttc agccggcagt cctacagcat tggcagtcgc 235681 cagaagaact acaagcgatc ctgagggtac agctgcaatg cctttactgg tcatcacaag 235741 cacaagcatc atgagcagct gctgggacaa tgtcatgtct acttgaaagg cctgtgcgag 235801 aaagatacaa gaaaccgata aatataagct ggagccgtca cagttcaatg acaagccgga 235861 gggaacgaca aatgatacca ctcgtttggg acagccgtat ttctccattc tatccatcag 235921 ctgagggaga atggtttcag tgcttgtggt ggaaaatgca attaaaaaca gatcccatat 235981 cattttcaat acttcgaaat acttaatctg aaagatgaga ccgacaagcg gaaagaggac 236041 aaagaggatc aggaacaggc caaggaatac ggtgccaacc agcttaaaca tagggaggag 236101 gagttcaatg ccatattggc ctacagaagc agccatcagg gctaacacgc cgataggagc 236161 agtgaccatg acgatttgcg tgagcttgaa cataatctga gctgtagatt caaaaaactt 236221 cattactggt tcagaagctt tgccgatacc agctgcggcg acaccaaata aaatggcgaa 236281 gaaaataacg gcaagcaaat catttctggc catgacatca ataatgtttg tagggataat 236341 atccaggatc atttgcttga aatcaacaac tttgtctgtg tagccggaaa gttcatgaat 236401 atcttttttt gccaaatggg agaggtcaag cccgacacct ggttttaaga cattcgctaa 236461 taaaagtcca agccctaata ccaacgttgt aatcacttcg aaccaaatga tcgtcttgat 236521 gccgagactg cccatttttt tcatgcttcc gcttcctgcg gctccaatga caatggtaga 236581 aaatacaatc ggcacaacaa tcattttaat caggcggata aatccatctc cgacaggcct 236641 cagtgccatc ccgaaatcag gaaaaaagtg gccgatcacc gcgccgacag ccaaagcgat 236701 taaaatttga aacgcgatta attttttcaa atgaatcccc ctttagaacg atagaatgta 236761 ggcatattca tatcattcgt gattcaaatg caaacacctt ttttcaagtt attttatttt 236821 gacagcgctt tcattatgtt ggcgaaaaag tcccccgcag caggggggac ttttttactt 236881 catttgaatg tgctttagat cttcttcaga ggtatttgtg aaaataaccg gtgttatggc 236941 tgaagcggca tgctgcttga tgtaattgag atcaaaggtg agaagcagtt cgccttgttt 237001 gacggcttgt ccgcttgtga catgtgcttc aaagccttcc ccattcagtt tgacggtatc 237061 gatgccgaca tgaatcagga tttcagtgcc gccggcgctc ataaagccga tggcgtgttt 237121 tgtcggaaaa atcgagacga tctcgccgtc cgcaggtgca acgacttttc cttctgatgg 237181 tataatcgca aatccctcgc ccatcatttt ttctgaaaag acctgatcag gcacatcccc 237241 taaagagact gtttctcctt taatcggata aataaaggtc tcatcggaat cgggcttcag 237301 cggtttgtca gttaccgtgt ccagcgcggc ggcggtggca gggacgcctc cggccatgat 237361 tgttttgatg tcgtctttta aggcatcgga cttggttccg aatattgcct ggaagttgtt 237421 gttgacctcc agcacaccta ctgcaccaag ccgttttaat tcatccttgc agacttggct 237481 tggctgatga acggtcacac gaagccttgt gatacatgca tccaggttag cgatattttg 237541 ctgtccgccc aaggcctgca gcacgtgaaa ggcaagctgg tcttttgcaa ctggagcttt 237601 ctcctcattc tgaccgtctt catctgtctc acggccgggc gttttcaaat tccatttcag 237661 aatcgcaaat cggaacaaat aataataaat gaaagcaaac acgatcccga caggaatgac 237721 aacccagccg tttgtagaca gtccgtagtt caagacgtag tcaattcctc cgcctgagaa 237781 cgtatagccg tggcggacat ggaataaatc acaaacgaca aagatgacgc cggcaagaat 237841 agagttaatc aaatagagca cgggcgcaac gaacaagaaa gaaaactcaa ccggttctgt 237901 aattccggtc agcatagatg tgagcgccgc agaaatcatc acgccggaga tcattttttt 237961 cttttccgga cgcgcggtat ggataatggc aagagcaacg gccggcagac agaaaatcat 238021 gtaagggaaa tcccccatca taaagcgccc ggctgtcggg tctcccgcga aaaaccttgt 238081 caggtcgccg gttacggtgt tgcctgttga tgggtctgtg tattctccca tcataaaata 238141 gaaaggcgta taaaaaatat gatgcaggcc aaaaggaatc agcaaacgat agatcgttgc 238201 ataaaagaac aggccgactg ttgaatcggc aattaaactg ctggctgcgt taattccgtt 238261 ttggatcagc ggccaaacga atgagaaaat gacgccgatc accaatgaac tgacggaagt 238321 aatgatcggg acaaagcgtt ttccagagaa aaatccaagg accggatgca gctcgattga 238381 tgaaaatcgc ttatataaat aggcggcgag aagcccgata atgattcctc cgaaaacccc 238441 catatcaatc aggtgctcgg ctccttcata cggaggctga aggccgagta attttcccat 238501 attgtcgagg gtgacggtta aaattaagta tccgatgaca gcggcaagtc cggctacacc 238561 ttctccgccg gctaatccga tcgcgacccc cacggcgaaa atcagcggaa ggttatcgaa 238621 tacaacgccg cccgcatcct ttataatagg gatgttcagt aaatccttgt ctccgaaacg 238681 gagcaaaaga cctgctgccg gcaggacggc aaccggagtc atcaacgcgc ggccaagctg 238741 ctgcagaatt tgaaatgcct ttttaaacat gacagtctcc ttttattgtg ttatgagaat 238801 gatgcactct ttaatttttg agctgcttta taatcggcga taacggttac atgattgtgt 238861 ttttgaagaa tggaggctgg tacatctgtc gtgacaggac cttcagccat cttttgaatg 238921 gcgtctgctt tttcctcgcc gcttgctaaa agcacaatat gtttgctgaa ttccatgatg 238981 gttttaatgc ccattgaaat cgcgagtctc ggaaccagca ccggatcgcc gccgaagaat 239041 ctggcatttg cctgtatcgt gctttccgag agcttcacaa cacgtgtccg gtcttcaaaa 239101 tcagatcccg gttcattaaa accgatatgg ccattggcgc cgatgccgag aatttggaca 239161 tcaatgcctc ccgcctggcg gatgagatcc tcgtatactt tgcatgccgc ctcaagctgc 239221 ggattgtctc cttgcgggat atgaatatga tcaggctgca tattgatatg ctgaaaaaga 239281 tgctcatgca taaaatggtt ataactttgc ggatgagatg gagagagacc agcatattca 239341 tccaaattaa atgtagtaac ctttgaaaaa tcaatttcgc ctgcctgata gtctgaaatc 239401 aactgcttat acaagccgac cggtgtgctt cctgttgcca ggccgagaac ggcatctttc 239461 ttagcttgta tttgttcttt aataatggca gcgcttaact tacagagttc ttcgtagtgc 239521 tcggcgatca gaatcttcat gtgacacccc ctcaaagaga tagacaagca ccatatttgt 239581 tatgaccaat ttatgatact tgtcattacg aatttagcac cgcccttatc aaactgtcaa 239641 tattaatttc tgaaaatttg ttataaaaga aggatacaaa tctttcatat tgggagggca 239701 aatggtatta tggtctcaat gaaaaagaac ggattgcata cagaatgggg agaatgaaat 239761 gacagcttta tattctgtta tcaagtttaa aatcattgag ttaattaaat cgggcaaata 239821 tcaggcgaat gatcagctgc cgacggagag tgagttttgc gaacaatatg atgtcagcag 239881 aacaactgtg agactggctc tgcagcagct agagcttgag ggatatatta aaagaattca 239941 aggaaaaggg acatttgtat cggcggccaa aatacaaacg ccgattccgc ataagattac 240001 gagctttgca gaacaaatga gaggacttcg ttctgaatca aaagtgcttg agcttgtggt 240061 gattcctgcc gatcattcca tcgccgagct tttgaaaatg aaagagaatg aacctgtcaa 240121 caagcttgtc agagtcagat acgccgaggg ggaacctttg cagtatcata cctcatatat 240181 tccctggaag gcggcaccgg ggctggcgca ggaggaatgc accggctcgc tgtttgaatt 240241 gttaaggaca aaatacaata ttgaaatcag caggggcacg gaatcgatcg aaccgatttt 240301 aacggatgaa acgatcagcg gacacttatt aaccaatgtc ggagcgcctg cgtttttatc 240361 agaatccctt acctatgata aaaatgaaga agtggtggaa tatgcgcaaa ttattacacg 240421 gggagaccga acgaaattca ccgtagaaca gtcatatcat tcataaagca atgtgtttta 240481 agaagggaat ggtggttcta tgtttttatt tacgaatgga aaagtgctgt ggggagcagt 240541 gattgctgca ttcatccttt caattgtatt ttaccctttt ctgccgacgc agatgccgat 240601 tcattatgat gttgcgaaca gtccggatct gacggttaac aagctggcgg ggactgtgat 240661 gctgcctgtt ttgatggtgg tgtttgcatg ggcgcggaag atcaattggc aatttgtatt 240721 cgcagtgtat attttgctga tttgccacat tgtcgtcctt tgtttagcgc tctaaatcaa 240781 acagccagaa taaaactggc tgttttcttt aatttcagct tcatctgaca atgaatgtgg 240841 tgtataatag ctgatgatcc taaagaatat tctgaaattt ataggtgtga agcggcgtat 240901 tattaaagga aaggctgtat actttttgca gctttaaaaa gactgaatat ttaaacaatt 240961 atgtgaaagg tgtgctgatt agattgaata agcttattga acgagaaaaa actgtatatt 241021 ataaggaaaa gcccgacccg tcttccttgg ggtttggaca atattttaca gattatatgt 241081 ttgtgatgga ctacgaagag gggattggat ggcatcatcc gagaattgcg ccgtacgcac 241141 cgcttacgct tgatccgtct tcatctgttt ttcattacgg ccaggctgtt tttgaaggat 241201 taaaagcata cagaacagac gacggcaggg tgctgctgtt ccgtccggat caaaatatca 241261 aacggctgaa cagatcgtgt gagcgcatga gcatgccccc tttagacgaa gagctggtgc 241321 ttgaggcatt gacgcaatta gttgagctgg agaaagattg ggttccaaag gaaaaaggaa 241381 cgtcactgta tattcgtcct tttgtcattg ccacagaacc gagtctcggt gtgaaggcat 241441 ccaggagcta tacatttatg atcgtgcttt cgcctgtcgg ctcctattat ggcgacgatc 241501 agctgaagcc ggttagaatc tatgtcgaag atgagtatgt gagggcggtc aacggaggag 241561 tcgggtttgc aaaaacggct ggaaactatg ccgccagtct tcaggcacag cggaaagcga 241621 atgaactggg ctatgaccag gtactgtggc tggacgccat cgaaaagaaa tatgtggaag 241681 aagtagggag catgaacatc tttttcgtca taaacgggga agctgtcaca cctgctttaa 241741 gcggaagcat tttaagcggg gttacacgtg cgtctgcgat tgaattgatt cgaagctggg 241801 gcattccggt tcgtgaagag agaatatcga ttgatgaggt gtatgcggcc tctgcacgcg 241861 gagaattgac agaggtcttt ggcacaggca cggcagcagt cgttacgcct gtcggtgaac 241921 tcaacatcca tggaaaaacg gtgattgtag gcgacgggca aatcggggac ctctcgaaaa 241981 agctgtatga aacgataaca gatattcagc ttggcaaggt aaaaggcccg tttaactgga 242041 cagtggaagt gtgaaaatcg aaaaagaacc tgcccggagg caggttcttt ttattttgaa 242101 tgagtcatat cagcagccgg ctggcttttg cggtttttta cataatatat tgcatagcaa 242161 atggccataa atggaacgcc gcaatagagt gcgattcttt gattcggatc aaaggcaatg 242221 ccaacgacgg aagccaggca taacaggaac gcagcaatcg gcacgaacgg atacaaaggg 242281 gttctgtatt tcaaatcagt aaccttgttt cccgcttcga tataacgttt tctgaacatg 242341 aattgagaag cagcgattcc catccacacg acaacgacgg caaaaccgga aatcgacacg 242401 agcacaacgt atacagtgtc tggcgcaaat acgctggaca gcaacgacag aatgccgccg 242461 atcatgctga acaccagcgc gttaaaaggg gttccttttg acgtcagctt tgcaaatgtc 242521 ggatgaagcg ttttttcttt tgataaagac cacagcatcc gggaagaagc gtagagtccg 242581 gaattagccg ctgacaggat cgctgtcagg ataacaaagt tcatgatatc ggctgcgtat 242641 ggtacaccga ctctgtcaaa gacagcgaca aacgggcttt tgatgacacc tgcatcttga 242701 atcggaatca gccctgacag cacaaaaatt gttccgacaa agaagagcga gagacgccag 242761 accgttgttt ttatcgcttt tggtatcgtc ttgtcaggat caacgctttc accggctgcg 242821 attccgatta gttccgttcc cgaaaaggca aaattgacgg acagcatcgt catcaaaatc 242881 gggacaaatc cattgggaaa aagcccgcct tccgccgtga agttggacag catcggagcg 242941 gcttctccgc ctttgatcgg gatgatgccg aacatggcag agccgcctaa aagaataaat 243001 aatacaatgg ctaatacttt gatgctggaa aaccaaaatt ctgattcagc gaaaaacttg 243061 accgaaaatg cgttaagcaa gaagatgaac agcgcaaaga cggcactcca catccaaacc 243121 gatgtatggg ggaaccagcg ctgcattaac aggccggctg ctgtgaattc tgatcccaat 243181 gccacggtcc atgtcagcca atacagccaa gcgaccgtaa atccggtgcc cggccctatg 243241 tatttggctg cataggtgtg aaaggcgccg gtcacaggca tggcgactga cagctcaccg 243301 aggcatagca tgaccagata gacgatgccg gccccgacta agtaggcgag tatcgttccg 243361 gccgggcctg cttgctgaat ggtataacct gagcttaaaa acagcccggt tccgatgaca 243421 cctcccaagg aaagcataaa gaggtgccgg cttttcatac ttctctgaaa ggttgtctca 243481 ttcttgttgt gggcagagtt catctttttc caactttcta tcagcgattt atttccttcc 243541 taataaaaaa tctcatgtca gaaagtgaca cgagactccg gcgaaccggc tttaagttag 243601 aatatacaaa ctattccgat aagtcaagtt gtttttaaag agcgggccca agccgcaatt 243661 tcttgaatat tttcgggttt tgtccggcag cagccgccaa tcagcctcgc tcctttttca 243721 tgccaggtgc gggcgctcgc cccgtaagat tctgcgcatg ctgcgccgtt ccacgttttt 243781 gtttccggat catattgctc acctgaattc gggtagacaa tgatcggttt tgacgtgttc 243841 ttttttaact cctctatcaa ggaagggata tgctgaagcg gcgtgcagtt gatgccgagt 243901 gctgcaattt ggcggtgttc atcaagccac gatgcgcagt cagctgcagg tgttccgtca 243961 ctgatatgca agccgtcttt agcactgaag ctgatccatg catacgtttc aggaaattcc 244021 ttcaacagcc gaacaatcgc tttggcttca gtcagacacg gaatcgtttc gcatgccaat 244081 acatcagctc cggcttcaat cagcgccttc atccgggggc gatgaaattc aatcagttca 244141 tcttctgata ttgcgtagtt gccgcgatac tcagacccgt ctgcaagata agcgccataa 244201 gggcctatag aagccgcaat gatcggtttt ggccgattca aacggttctc ttcaagcgac 244261 caaaattcat cacgtgcttc agctgcgatg ctgacggaca actcgatgag ccggcgtgct 244321 tccgcttcgc tcagcccgcg tgcggcaaag ccttcaaatg tagactgata gctggcggtg 244381 attgcacaat cggcgcctgc cgcaaaataa tcagtatgaa cttgtttaat cagctccggc 244441 tcttccatca ggatttttgc cgaccacaga ctgtcattca aattacagcc cttgcgttca 244501 agctcggtcg ccatggcgcc gtctagcaca ataagcgggt atgtatctaa tatgtgttgg 244561 ataggattca tagaatgtac cgatgccttc tttcagattt ttttgaaaaa gatatgaaaa 244621 tcgtaatgga ggcttacgtg tttgtcaata aacgcaaaaa gagaaaggtg ttcagcccat 244681 atgtctgaac acccttttct tatgatattt gtttgttgtg cgtgtcagtc tttgtgtctg 244741 aaaccggcca gcactcaatg ccattatggt ttttgagcac atctttataa aagaccggat 244801 ccttgcctgc ttttttctgg cgtgtatagt ctttcagcgc cgtaaaaacg acctttgata 244861 gtaagaaaat cgcgattaaa ttcacgatga ccatcaaacc catgaacaaa tcagcaagat 244921 cccagacgag ctggactttg gcaacacagc caaacacgat cattgccagc acgccgatac 244981 ggtagacaaa aatcagtttt ttgcttttgt tcaaaaagcc gatattggtt tcgccataat 245041 aatagtttcc aattagagca cagaatccga ataacaaaat cagaatcgcg agaaagcctg 245101 atgcccatga tccgacatgg gagctgaggg aggcttgtgt caaggcgatt ccgctcagac 245161 ccggagtatg ataggcatcc gaaaacagaa tgataaaagc ggtgcttgta caaatgacca 245221 gtgtatctgt cagtacacca aaagcttgga tcagcccctg tttgacggga tggcttgttg 245281 tggcggtggc agcggcattt ggtgcgcttc ccattcccgc ttcgtttgaa aagattcccc 245341 gtctgacgcc ttgcatgagt gccgcgccca aagccccgcc ggcggcctgg tcaaaaccaa 245401 acgcattttt cacgattagc gcaagcacac ctggcagctg cgtaatgttg gagaaaatga 245461 cgaaaaacgc aactccgata tacaggacag ccaatacgac gacaatggat tcagccagct 245521 ttgcaatgcg cttgactccg ccaaaaataa tcgtgccgaa tacagcaatt aaaatgagtc 245581 ccaatgtcag gcggtttgtg ccaaacgcgt tttcaaaggc aaggctgact gtattggatt 245641 gaaccgagtt gaagacgata ccgaacgata aggtgattaa cacagcgaac agcgcgccca 245701 tccacctttt gttcagccct ttttccatgt aatacgccgg cccgccgcgg aagccgttta 245761 catcttttac tttataaatc tgagccagtg tgctttccac aaagctggat gctgatccga 245821 taatggcgat aatccacatc cagaagattg caccgggccc gccgagtgca atggcgatag 245881 caatgcccgt aatatttccc gttccgacac gggccgccat gctgatgcaa aaggcttgaa 245941 acggagaaat gctgtttttt gaccgggaag cagcaccttc tcttaatacc ctgaccattt 246001 ctttcagcat gcgaacctgt aaaaacttaa gcctgaacgt aaaatagatt ccaaaagaaa 246061 ggagcaaaac aattaatagc tttgaccaca aaagatcatt tgcaataccg acgatatgtt 246121 ctaggatttg ctgcatagaa tcacctcttt tttcatgttt aaaaaatgct gagctcccat 246181 tcctgcgcca tatgcttcag cagcataccg ccagtgaggc tgttgccgta ttcatcaatg 246241 gcaggcccgt aaatgccgat gccgcatccg gattgaaaag gctgttctct tctggcgctt 246301 ggaggcacca gcgccatgat gccgccggag acgccgcttt tggccggcac gccgacaaac 246361 gccgcatatt tgcctgaagc gttgtacatg ccgcacgtca gcattaatgc cttggccaat 246421 tttgccacat cttttggaat cacctgctcg tgtcgaatcg gatgataccc gtcatgagca 246481 aggatcaggc cgatcaacgc aatatcttct gtagtgctct ccatagcgca ttgcttcaag 246541 tacacctcaa gtgtttcttc tacttcagct tctaaaaagt ttgtttcttt taaatagtag 246601 gccagcgctc tgttgcggtg ggcggtttcc cattcagaac ggaatacttc ttcatgaatt 246661 cttggccgtt ttcctatcaa agtttccatc accgagtaaa gaaactcgag cttttcgtat 246721 gcagattctc cgggaaggat cgaagcgatg gtgagggcac ccgcgttgat catgggattg 246781 aagggctttc ccggcttgtt gatttcgagc cgaatgattg aattaaaggc gtcacctgtc 246841 ggctcgacat ctacgcggtc aagcacatag ggaatgccgc ggctcatgca ggcggcaata 246901 aagctaatca cttttgaaat gctttgcatg gtaaaagaga cgttccagtc gccggcgtgt 246961 atcatcgttc catcaggctc caatacacag atgccgagct gtgaatcatt gacttttcct 247021 aaagcgggga tatagtttgc gctttgtcca ttggcggcaa aagggcgata gtattcaacc 247081 caatcatgaa gctgtaacgc cgggtttatg tctttctggt gctcttttat caattctttc 247141 atcgaattcc tcctcactga tttttttctt aaaggactga ggtgtatcaa aacgaaggct 247201 aagggggcgt taaacgcttt cataatagcg gaaggtataa ttactgtata atggagacta 247261 cagaatcata caaaatacga caaaaacatt ttgaaaataa gcagtaagat ttataaaaac 247321 ctcatgttct gggtcaaaag caatttgcag gttttctccc gattccccaa aataaaaagc 247381 gaggatgtga tcaacataaa actggaacgg tttattgaaa aagacggata tatactggcc 247441 ctcatgctga ttacggtgcc gctggccggt gaactgaaat tttatcccct caatgaagaa 247501 ttccgggtca gctttggggc accggttttt ttcttctttt tatcattgtt gcggcatgtg 247561 cccgctgtgc tgccgggttt tctgactgga gcggctgttt tcatctttcg cgtctttctg 247621 gaattatggg gcggaggaca caatgggctg actccgattc tgtatgatca agcgtctggc 247681 tttttctttt atatgactta cgcctgtctg ttttccatat taaaggccaa tcgtttccgt 247741 gaacggccga ttatgctcgg tttcattggg tttatgattg aagttgtgtc agattgtgtc 247801 gagctaactg tgcaatttct catttttcat acggttgtca cgcctgagaa aatcactgac 247861 attgcggtga ttgcgatttc tcacacattt attgtgatga gcttttatag tgtgctgaag 247921 ctgtatgaaa cacaatcgag agaaaaacag acaaggcagc agcacgagca catgctgatg 247981 atcgtttcca atttatatga agaaacggtg cacctaaaaa agacattgaa aacgacagag 248041 aaagtgacaa acgattcgta tcagctctat cgggaaatga agggcaagga tgttcagctg 248101 agcggcagaa tcctgagact ggccggagag attcatgaag tgaaaaagga caaccagcgg 248161 atattcgcag ggctttcaaa actgatttcg aatgagagtt tgagagatta tatgagggct 248221 tctgatttgc tgcagctcgt gattcgaatg aatgaaaagt acgctgaagc actagggaag 248281 cagattgatt tttactgctc gatcgaggga gagcatgacg aatatcacgt atttatcgtg 248341 ctttcgatca ttaataatct aacagcaaat gcggtagagg ctatggatga agagggaatg 248401 gtcagcctga ggctccgtaa gccaaatgag agtatggtag aattccaggt ggaagacaat 248461 ggccccggga tttccgagaa aatcggagac attgtgtttg acccgggctt tacttcaaaa 248521 tatgacgaat ttggcacgcc ttctacgggt atcggacttt cctacgtaaa ggaaatcgtg 248581 acagagctag aaggggatat cacgtttgat aatcagcagc ggggagtggt gtttgccatc 248641 aggctgcctg tccggcattt gattcagaaa gggtgaacca aaagctatgc gtttttttat 248701 tgcagatgat gaccgtgcgg tgcggtcaat tttaaggcag atcattgagg acgaagatct 248761 cggggaagct gctggtgaag cagacgacgg aagccaagtg gaagggcata tgctgcaatt 248821 taagcagatt gatattttat taatcgatct gttaatgccc ggaagagacg gcattgagac 248881 gattcgtcag atccagaata cgtactccgg caaaatcgta atgatctctc aagtggaggc 248941 gaaggaaatg gtcggggaag cgtactcgct cggcatcgaa tattttatcc ataagccgat 249001 taaccgcatt gaaattgtca cggttctcca aaaggtgaag gagcggatcg agcttgaaca 249061 ctcgattgga gccattcagc attctctaag ccggcttgtc aatcggactg aacggaaagc 249121 gcgtccccag cagaagagtg acagcggttt aaaagaggca ggaacattcc tgttgtccga 249181 gctgggcatg atgggagaag gcggcgcaca tgatctcatg gcggtcctgc agtatttagc 249241 agaacacgag caatccgagc cgcacgaaaa acaaagccct tcgctaaaac aaatattcac 249301 ccaagtagcg gtacggaagc tggggacagg agcctcacag acggaagtca atcgcgaaat 249361 gaaagcctcg gagcagcgta tccgcagagc gattattcat tcgctgcacc attttgcttc 249421 actgggcaca actgattttt cgaatccaaa atttgaaacc tatgcatcga aattctttga 249481 ttttccggtt gtcagccaga aaatgaaaga actccaatcc aaggatgcaa aaccccttgc 249541 acctgctaga ataaatatga aaaaattcat ccacgtgttt tttttggaag caaagctttt 249601 gcatgagacg atgaaacaaa gaaggatata aaccaaacag ccggctgacc aggctgtttt 249661 tttgctgcgc agaatcccgg ccggacagtg atttaccgct tttttataaa atatcagaaa 249721 ataaagatat tgacttattg tttatttgtc ttacaattaa acaaaaggat atatgggaag 249781 gagcggatgt gaaagaaaaa ttaataaaag cgcttacaga tagaggccgt atacacaaat 249841 aacaggaggt tatgttgatg agccgtatca gaaaagcacc cgctggaatt ttaggttttc 249901 cggttgctcc ttttaacaca caaggaaaac tggaggaaga agctcttttt caaaacattg 249961 agtttttgct gaatgagggc ttggaagcga tatttatcgc ttgcgggtct ggtgaattcc 250021 aatctctcag ccagaaggaa tatgagcaaa tggtggaagt cgcagtctcg gcagccggag 250081 gaaaggtgcc ggtctacacg ggggtgggcg gcaacctcag cacagcgctt gattgggcgc 250141 agctgtcgga gaaaaaaggc gccgacggct acttgattct gcctccgtat ttggtgcatg 250201 gcgaacagga ggggctgtac cagtatgcga aaacgattat tgaaagcact gacttgaacg 250261 cgattcttta tcagcgcgat aacgcagttc tctctgttga acagatcaaa cgtctgaccg 250321 aatgtgaaca gcttgtcggt gtcaaagacg gggtaggaaa tatggatttg aatatcaatc 250381 tcgtctatac gatcggcgac cgcttgggat ggctcaacgg aatgccgatg gctgaagtga 250441 cgatgccggc ttatctgccg atcgggttcc actcttactc ttcagcgatt tcaaattata 250501 tcccgcatat ttcgcgaatg ttctatgatg cattgaaaaa cggaaatgac gagcttgtga 250561 aggaactcta tcggcatgtg attctgccga tcaacgacat tcgcaaacaa cgaaaaggct 250621 acgccgtatc cttgattaaa gccggtatgg aaatcatggg tttgaatgta aggaatacag 250681 ccagaccgcc tgtcggcccg gttgaaaaag atcattatca gcaattggaa gcaattttga 250741 agcaggcggc tgaccgtttt ccgaaaaaag ccgcgacggt ttgaccagaa aaaacacgaa 250801 aggggcaatg ggcatgtctg tgatcacgga acaaaacacg tacctcaact ttattaacgg 250861 agagtgggtt aagtctcaat caggcgatat ggtcaaagtc gaaaaccctg ccgatgtgaa 250921 tgatattgtc ggatatgtac agaattcaac ggctgaagat gtggaacgtg ccgtcaccgc 250981 cgccaatgaa gccaaaacgg cttggagaaa gctgacgggt gccgagcgcg gccaatactt 251041 atacaaaaca gcggatatca tggagcagcg cttggaggaa atcgccgcct gtgcaacgcg 251101 tgaaatgggt aaaacattgc cggaagcgaa gggagaaaca gcccggggga ttgccattct 251161 gcgctattac gccggagagg gcatgcgaaa aacgggtgac gtcattccgt ctactgacaa 251221 agacgcgctc atgtttacca cccgtgttcc gctcggtgtg gtcggtgtga tttctccgtg 251281 gaacttccca gtggcgattc cgatttggaa aatggcgccg gcattggtat acggcaatac 251341 cgttgtcatc aaaccggcga cagaaacagc tgtgacatgc gcgaagatca ttgcctgctt 251401 tgaggaagcg gggctcccgg caggggtcat caatttggtg acaggcccgg gttctgttgt 251461 cgggcagggg cttgctgagc atgacggtgt aaacgccgtt acgtttaccg gttcaaatca 251521 agtcggaaaa atcatcgggc aagccgcttt agcgagggga gccaaatatc agcttgagat 251581 gggcggcaaa aaccctgtca tcgtagctga tgacgctgac cttgaagctg cggcagaagc 251641 tgtcataacg ggggccttcc gttcaaccgg ccagaaatgc accgcgacaa gccgtgtcat 251701 cgtacaaagc ggaatttacg agcgctttaa agaaaaactg ctccagcgca caaaagatat 251761 tacaatcgga gacagcttaa aagaggatgt ctggatggga ccgatagcca gcaagaatca 251821 gcttgataac tgcctgtcat acattgagaa aggcaaacag gagggcgctt cccttttaat 251881 aggaggagaa aagctggaga acggaaagta tcaaaacggc tattatgttc agcctgccat 251941 ctttgacaat gtgacatctg agatgacaat tgcccaggag gaaattttcg gtccggtgat 252001 cgccttgatc aaggtggact cgatagagga ggcgctgaac atcgccaatg atgtgaagtt 252061 cggtttaagt gcatccatct tcacggaaaa catcggccga atgctttctt tcattgatga 252121 aatcgatgcc gggctggttc ggatcaatgc agaaagcgca ggtgttgagc tgcaggcgcc 252181 ttttggcggc atgaagcagt cgagctccca ctcccgagaa cagggtgagg cagcgaagga 252241 ctttttcaca gcgatcaaaa ctgtttttgt gaagccgtaa tggtgctgga aagaggcgtg 252301 cgtctctttc ccggtttatc acaaccagca tatgattctc tactttgaaa aggagaagat 252361 actatgaaaa aagactttgc gagtgttact ccggcgggca aaaaaacgtc cgtgcgctgg 252421 ttcatcgtgt ttatgctgtt tcttgtgacc tctattaact acgcggatcg agcgacgctt 252481 tccatcaccg gagattccgt ccagcacgat ttgggattgg actcggtcgc catgggatat 252541 gtcttttctg cctttggctg ggcctatgtc atcggacagc ttccgggcgg ctggctgctg 252601 gaccgttttg gttcaaagac tatcattgcg ttaagcatct ttttctggtc gttttttacg 252661 ttgctgcaag gggcgattgg ctttttctcc gccggcacag cgattatcct gctgtttgca 252721 ctgcgttttc tggttggttt atcagaagcg ccttcatttc ccggaaacgg cagagttgtt 252781 gcctcatggt ttccaagctc cgagcgcggg acagcttcag ccttttttaa ttcagcacaa 252841 tacttcgcaa tcgtcatttt ttctccttta atgggctggc ttacccactc tttcggctgg 252901 cattccgttt tcgttgtcat gggtattgca ggcattcttc tggctgtcat ctggctaaaa 252961 acggtgtatg aaccgaaaaa acatccgaag gttaatgaag ctgagcttgc gtacatcgaa 253021 cagggcggcg ggctgatttc catggatgac agtaaaagca aacaagaaac agaatcgaaa 253081 tggccgtata tcaaacagct gttaacgaac cgcatgctga ttggcgtgta catcgcgcaa 253141 tactgtatta cgactctcac ctatttcttt ctcacatggt ttccggtata tttggttcag 253201 gcccgcggca tgtctattct tgaagctggg tttgtcgctt ccctgccggc gctgtgcgga 253261 tttgccggcg gcgtgcttgg gggcattgtg tcagacatct tactcaaaaa aggccgttca 253321 ctgacctttg caagaaaagt gccaatcatt gccggcatgc tgctgtcttg cagtatgatt 253381 gtctgtaact acacagattc agcatggctc gtcgttgtca ttatgtcgct cgcgtttttc 253441 ggaaaaggct tcggcgcatt gggttgggct gtcgtgtcgg acacgtctcc gaaagaatgt 253501 gcaggattaa gcggcggttt gttcaacact ttcgggaata ttgcctcaat tacaacaccg 253561 attattatcg gatacattgt caatgccact ggatctttca atggcgcgct tgtgtttgtc 253621 ggcgctaacg cgattgcggc gatcctcagc tatttgctgc tggtcgggcc gatcaaacgg 253681 gtcgtgttaa agaaacaaga acaagacccc gatcaatcgt tgcctgtcta atatttatga 253741 aagcgcttta taaagggagg aaaatgcatg agttcaccga tacaagagca ggttcaaaaa 253801 gaaaaaagat cgaatattcc ctcaatttct gaaatgaagg tgattcctgt tgcgggacat 253861 gacagcatgc tgctgaatct aagcggagca cacagcccgt tttttacccg gaatatcgta 253921 atcttaacag acagcagcgg aaatcaggga gtcggcgagg tgcctggcgg agagcatatt 253981 cgccgcacac tggagctgtc agagccgctt gttgtcggaa aatctatcgg tgcgtaccag 254041 gcgatattgc aaacggtcag aaagcagttt ggcgatcagg acaggggagg gcgaggaaac 254101 cagacgtttg atttgcgcac cactgtgcac gccgtcaccg cactggaagc ggctttgttg 254161 gatttgcttg gaaagtttct tcaggaaccg gtcgcggctt tgctgggcga agggaagcag 254221 cgtgatgaag taaaaatgct cggttacctc ttttacatcg gcgaccgaaa tcggacgacc 254281 ttgccgtatc aaagcgatga gcagtcagat tgtgcgtggt tccgtctgcg ccatgaggaa 254341 gcgctgacgc cggaggccat tgtgcgtctt gccgaatccg cacaggagcg ctatggcttt 254401 caggatttca aattgaaagg cggggtgctg cggggagaag aggaaatcga agctgttacc 254461 gcattatcga aacgttttcc agaggcaagg atcactcttg atccgaacgg ggcatggtca 254521 ttagaggaag ctattgcatt atgcaaagga aagcaagatg tgctcgcgta tgcggaagat 254581 ccatgcgggg atgagaatgg ctactccgct cgtgaagtaa tggctgaatt ccgccgcgcg 254641 acagggcttc cgactgcgac aaatatgatt gcgactgact ggcgggaaat gggtcacgcg 254701 attcagctcc acgcggtcga tataccgctg gctgatccgc atttttggac gatgcaaggg 254761 tcggtgcggg ttgcgcaaat gtgccatgat tggggtttga catggggctc gcactccaac 254821 aaccactttg atatttccct tgcgatgttt acccatgtgg cagcagcggc tccggggcgg 254881 atcacggcga ttgataccca ttggatctgg caggacgggc agcgattaac gaaacagcct 254941 tttgagattt cttctggctg tgtcaaggtg ccggataagc ctggactagg cgtcgatatt 255001 gatatggaac aagtggaaaa agcgcatgag atctatcgga aaatgaattt aggcgcacgg 255061 aatgatgcga tcccaatgca gttcctgatc agcaactggg aatttgaccg gaagcgcccg 255121 tgtcttgtgc gataagtttg attgtaaata ttgtcatatc cgctattttg tcttacaatt 255181 gaacaactga agggagagtt gttcgtgtac gaaggtttag aggatttgaa agtcgataca 255241 gtcaatcgga aaacattagc caagcaggtc atcgaacgga ttgtccattt attatcgagc 255301 ggacagttga gggccggaga caaattgccg acagaaatgg aactgatgga cattttgcat 255361 gtcagcaggc cggtgctacg ggaagcactc agttcacttg aaacgctggg cgtcattacg 255421 agaaaaacac gagggggcac atatttcaac gataaaatcg gcatgcagcc attttccgtc 255481 atgcttgctt tggccactga taatcttccg gctatcattg aagcgcggat ggcgctagaa 255541 ctcgggctcg tgacaattgc cgcggaaaaa atcaatgagg aagagcttca gcgtttgcag 255601 aagacgatcg acgatattgc caacagcact gacaatcatt atggtgaagc ggataaagag 255661 ttccatcgaa ttattgcgtt aagcgccaat aaccccgtcg ttgaagggat gattcagtcc 255721 ctgctgatca cccatgcgaa aattgacagc caaattccgt acagggagag agatgtaacg 255781 gtcgaatatc acaaaaaaat ctacgacgcc cttgccaaaa gagatccgta caaagcacat 255841 taccacatgt atgagcatct gaaatttgtc cgtgacaaaa ttctaaaagg aatggatgaa 255901 aaataatggt gagcaaccgc agttgaaacg taagagctgc ggttttttta aaccaattta 255961 gaaaacgctt actaaaatat gaggagtgat tttcatatgg cgatgaacct caggaagaac 256021 caagcccccc tttacatcaa agtgcatgaa atagataaca ccgcgattat tgtaaatgat 256081 ggagggctgc caaagggcac tgttttctca tgcgggctcg tacttgaaga ggatgttcct 256141 caaggccata aggtggccct caccgatctc aatcaagggg acgagatcgt gcgttacgga 256201 gaggtgatcg gatttgctga tgagacgatc aaacgcggga gctggatacg ggaagccctc 256261 gtgagaatgc ccgctcctcc ggcgttagac gatcttcctc tcgcaaacag ggtgccgcag 256321 ccgcggcccc cacttgaagg atatacattt gaaggatacc gaaatgcgga tggcagtgcg 256381 gggacaaaaa atatcctcgg catcacgaca agtgttcaat gtgttgttgg cgttttggat 256441 tatgcagtca aacgaataaa agaagagctg ctgccgaaat acccaaatgt cgatgacgtt 256501 gtgccgctgc atcatcaata cggatgcggc gtggcgatca atgcgcccga cgctgtcatt 256561 ccgatccgca cgattcaaaa tcttgcgaag catccgaact tcggcggtga agtaatggta 256621 atcggattgg gatgtgaaaa gctcctcccg gaaagaattg cctccgaaaa tgatgatgac 256681 attctatcgc tccaggatca ccgaggtttt gcggcgatga tccaatccat tttggaaatg 256741 gcggaggaac ggttaatcag gctgaacagc agaacccggg tgtcatgccc tgtttcggat 256801 ctggttatcg gcctgcaatg cggcggcagt gatgcgtttt ccggcgtgac ggcgaaccct 256861 gccgtggggt atgcggctga tttattggtt cgcgcaggtg caacggtttt gttttctgaa 256921 gtgacagagg tgcgggatgc cattcattta ttaacgccgc gggctgtcag tgaagaggtc 256981 ggacaatcgc tgatcaaaga gatgaagtgg tatgacagct atcttcggcg gggagacgca 257041 gaccgtagcg caaacccgtc accaggcaat aaaaaaggcg gattatccaa tgtggtggaa 257101 aaagcgttag gttcggtagc gaaatcaggc acaagcccca tctccggcgt gctcggccct 257161 ggtgaaagag caaagcaaaa aggcctgctg ttcgcggcga caccggcaag cgattttgtg 257221 tgcggcaccc tgcagctggc tgcgggcatg aatttgcagg tgtttacgac agggagagga 257281 acaccatatg gcctggctgc tgcgccggtt ctgaaagtat cgacgcggca ttccttatca 257341 gagcattggg ctgatttaat cgatatcaat gccggccgaa tcgcgacagg agaggccagt 257401 atcgaagacg taggctggga aatcttcagg acgattttgg atgtggcaag cggccgcaaa 257461 caaacgtggg cagaccgttg gggtcttcat aatgatttgt gcttgtttaa tcctgctcca 257521 gtgacttgat tcatgttttt atagcggaaa gatggaatat gctgtaaaat gaaaatcagc 257581 gtataggaaa cggaggggtt acagcatggc attcattaga ttccgagtga cacgaattca 257641 atagtgaaca actctcgcct gaatgcgaga gaatcgggat gaatccgcct atgtatgagc 257701 ccttatatgg ttatcaaaaa agagggtggc gtgcctgccc ttttttgtgc cttcaagcat 257761 cccttctctc tactgcaggc cggagcatga gaaaggggaa atgggatgac aaaccttaac 257821 gaaaaacagc ttatcactga gattgtcggg cttgcacgca gccaaggttt gacggttcat 257881 tctgagaacg cgcaattgaa tgaaaccgga atggactttc aagttgtatt tgccaaggac 257941 gacacaggta tgccatgggt gctgcgaaaa ccgcggcgaa gtgatgttgt ggaaagagca 258001 tctgcagaag gcataacgct tgcctttctc cgcgcgaatc tgactgctga tgtgccggat 258061 tggagaattc atacaccgga attgatcgct taccccatgt taaaaggaac gccggctgct 258121 ggaattgact tggaacaaaa gcaatatgta tggaatatgg atcatcagcc gccgtcagac 258181 gactttgtcc gcacacttgc cgacatactg gctgaattac atggcacgga tcaaatatct 258241 gctgggcaat ccggaataga agtgataagg ccagaagatt tcaggcaaat gacagcagac 258301 tctatggttg atgtgaagaa taagcttggc gtatctacga cgctttggga aagatggcaa 258361 aagtgggtag atgatgatgc atactggccg ggtttctctt ctttgataca cggcgatctc 258421 cacccgccgc atatccttat cgatcaaaat ggacgtgtca caggacttct ggattggaca 258481 gaagcgaagg ttgctgaccc agccaaggat tttgttcttt atcaaaccat tttcggagaa 258541 aaagaaactg cccgtttgct tgaatactat gatcaagcag gcggccgaat atgggcaaaa 258601 atgcaggaac acatctcaga gatgcaggcg gcgtatccgg tggaaatcgc caagctagct 258661 ctgcaaacac agcaggagga acacatcaat atggcgctgg aagcacttgg tgtaacatcg 258721 gattaagaat tgacttcgtt tcatgaaccg agtattataa actctacaaa taatagaacg 258781 gattaacaat cgtgaggaag agcaagtacg catcagaatg gaggttcaga gagtcggtgg 258841 caggtgtgaa ccgatcctcc cctgatgccg aatgggcttc tgaattgctt tgctgaacgg 258901 atagtaggcg atgccgggtt tctctccccg ttaccaagag aggagtatcg aaacataggt 258961 tttctgtact tagagtgaac ggctgtatag ctgttaataa aggtggtacc gcgagaccct 259021 cgtcctttgc ataggacggg ggttttttgt gtttcttaaa ggaggtgacg gccaatgtac 259081 gatggctggt ggtggcatag cagatgagtt agaaaggagg atatcaaatg gtcattgcaa 259141 ctgatgatct tgaggtcgca tgtcctaaat gtgaaagagc gggagaaatc gaaggaacac 259201 cttgcccggc ctgcagcgga aaaggtgtta ttctgactgc tcaaggatat acgcttctcg 259261 attttatcca aaagcatttg aataagtaaa ggagaaaagc tgagctgaga tgagagcaga 259321 agagcagagt aagattcgtg aggccgcagc aggtacgatt tttttgctga tcggaacagt 259381 ttgttttgcg tctaaatcga tttggataaa atgggcatac caaatgggtg ctgagccaga 259441 tgccgtgctg ctatacaggc agctgctggc tgttccgctg ttttggctga tttttttaat 259501 ataccgtcct ccaatgccag acggtaagaa aaaaggagac ctatggaagg cttgtggcgc 259561 gggagtgttt tgtttttttc tgtctccctt gcttgatttt atcgggctga accatgtatc 259621 cgcaatggtt gaacgtatat tgctgatgag ctatccgttg tttgtgtttg gattcaccgc 259681 gtgtcgtgac cggaaaatgt cctcaattca ggaccttttc gcagttctgg cggtcatgtt 259741 tgggcttttc ttggcgctgg gcggctggaa tgctgagctt ttccaggcga atatgattgg 259801 agctgtattc attttgttat cttcggccgt ctatgctggt tatcttgtcc tttccgggca 259861 tctcgtccat caaatcggag ggatccgtct caatgcatac gggatgacag ctgctggagc 259921 tgccatgatg ctttacacag ggataaaatc ggcggctggc atgaatacgc caatggcagc 259981 atatccgctt tctatgtatg gtttgttcgc agtaattgca gtcgttacca cagtgattcc 260041 atttgtgcta atgcttgagg gcataaaacg aatcggggca cagcgagccg ccgccatttc 260101 aatggcaggg cctatcctga cgattttcta tggagcttta tttctcggtg aacggctcgg 260161 gctcattcaa gtcattggat gcggtggcgt attttttgtc attacgggca tggaatacag 260221 gaagctgaaa acaggaaaaa aagaataatt tttataaaac acacacgttt ttcaattaca 260281 ataagtgtaa ttacgtgtgt gttttttgat tttgtaaagg ttaggtgagg agatgcagcg 260341 catattgctt gtagaagacg accactcaat cagtgaaatg gtggatcatt atttaacaaa 260401 agaaggcttt ggaattgtgc atgctttcga cggagaagag ggcatccggc tgtttcagca 260461 gggttcatac gatttggtcc tccttgatat catgctcccg aagctgaacg gcatggattt 260521 tctgaaaatc atccgggaaa aaagcaatat accggtctta atgatttcgg caaaagatgg 260581 agatgtggac aaggcattgg gactgggctt tggggcggat gattatatcg ccaaaccgtt 260641 ttcgatgatt gagctgacag cccgagtaaa agccgcgata cggcgggcga cgcaatattc 260701 ggcagaggag ccggctgtga ataaggtgat ccggattcac cagcttgcga tagatataga 260761 caatgtttcc gttttgaaaa acggagagcc gctccagctg acgtcaacag aatggcagct 260821 gctgtgctta tttgcatcaa atcctaaaaa agtgtttacg aaagaacaaa tctaccgttc 260881 cgtttggaat gaagagtact ttgatgatca gaacatcatt aacgtacata tgcggcggct 260941 cagagaaaag attgaggatg acccctcctc ccctcaatat attaaaacgt tatggggcat 261001 cggttataaa ttaggagagt tttagaatga cagtgctatg ggtggccgct gtcatcgctc 261061 tggcgtgtct gaatgtgatt caattcataa tgaaaaagaa gcgggacggg aatctggctt 261121 acacggctga ccagcttagc tacatgctca gccgggattc ggcaggacaa attttgcttc 261181 ctacagacga tcatgcgctc aaagacttgc ttgttaacat caatcttatc gttgagaatc 261241 gtcagcagat cagcgcccaa tttgccaaaa cagagcaatc catgaagcgg atgctgacca 261301 atatgtcgca cgacctgaaa acgccgttaa cggtcattct cggttatatt gaagccattc 261361 aaagtgaccc gaacatgccg gacgaagagc gggaaagatt gctggggaag ctccgccaga 261421 aaacaaatga acttattcag atgatcaatt ccttttttga tttagcgaaa ttagaatctg 261481 aagataaaga gatcccgatc accaaagtac atatgaacga catatgcaaa cgaaatatcc 261541 tgcactatta tgacgctgtt cagtcaaaag gctttcaagc agccatcgat atccccgata 261601 cgccggtgta tgcgcaggcg aatgaagagg ctctggacag aatcctgcaa aacctattgt 261661 ccaatgcgat tcaatatggc gcggccggca agttaatcgg gctgacgctg tcttatgatg 261721 agaggaacat cgccatcacc gtatgggatc gcggaaaagg gattagtgaa accgatcagc 261781 agcgggtgtt tgagaggctg tacacactgg aagaatccag aaataaagca tttcaaggaa 261841 gcggcttggg tttaaccatc acaaaacggc ttacagaaaa aatgggaggc atcatatccg 261901 tccaaagcaa gccgtacgaa cggactgcat ttacgatcac attgaaacgc atgacatatt 261961 aatcgtaaga atttcttaag gtttgagaaa taaaaatgac agggctcgcc gctacaatag 262021 aaaacaggaa aagagaggga aggagaaaca aagttgactt atatcgtaca aacaaacggg 262081 ctgaccaaaa catatcaggg caaagaggtc gtatccaatg tcagcatgca tattaaaaaa 262141 ggtgaaatct atggctttct cggcccgaac ggcgcgggga aaacaaccat tatgaaaatg 262201 ctgacgagcc ttgtcaaacc gacaagcggt gaaatcatca tccttgggaa caagttcacc 262261 cacacgtcat atgaggtgct ggggaacatc ggcagcatga ttgaatatcc gattttttat 262321 gaaaacctga cagctgaaga aaatttagat ctgcattgtg aatatatggg ataccacaat 262381 aaaaaagcca tacaagaagt gctggatatg gtgaatttaa aacaaatcga caaaaaaccc 262441 gtcaaaacct tttccctcgg gatgaagcag cgccttggaa ttgcgcgtgc catcctcacg 262501 aagccggacc tgcttattct ggatgagccg gtgaatggtc ttgaccctct cggcattaaa 262561 aagatcaggc aattgtttca agtgctgagc aaagagtacg ggatgacgct gctgatctca 262621 agccacctgc tgggtgaaat cgaacaaatc gcggacacaa tcggcgtcat tcgggacggc 262681 aggctgcttg aagaggtatc aatggaggat gtcaggggcc agaacactga atacatcgag 262741 cttgtcacgc cgaatcagac aagggcctgc tttgtgctgg agaaagagct gcaattaacc 262801 aactttaaaa tattaaatga gaaaacgatt cgaatttacg aggctgaagc ctctcaggct 262861 gccatatcca aagcattgat tttaaatgat gtagacattg aatcaatgaa caaaaagtat 262921 acgtcgctgg aggattattt tatcaaattg atcaacggca atagcatcag tgcgtaaagg 262981 aggagagaca cgttgatgaa tttgatcaga atcgaattaa gaaaaatgaa aatgggctgg 263041 tatatcagag gtgccctcat tgccaacgtg atcattatgg gttttatgtg gctgatcagt 263101 tattccgaaa aagccgatgg cggggtttcg ttccaaagta cggatgaagc attcctcatc 263161 atcggcacct tcgtcagagc ggtatttatc gtatttggcg ctgtgctgat cgtaaaattg 263221 gtgatttcgg aatataaaaa caaaaccatt cttgtgatgt tcacgtaccc gatcagccgt 263281 aaaaagctgc tcaccgctaa gctcatgatc gcgggcggac tgacgtttat cacgatttta 263341 ctttcaaata tactcatagc cgccggtttc ttttggctga actcgatctg ccatttcata 263401 ccgggagagc ttacttccga gatcatttct caacaggcgg tcaaaatggc ggttttcgct 263461 tttggcgccg ctggaaccag tttagttccc atcttttttg ggatgcgtag acactcggtt 263521 ccggcgacca tcatttcatc tgtagtaatt gtgatgctca tcagctcaac aagtccgggc 263581 ttctcgattt catctgttgt gtatatcccg ttatcgttag cggcattcgg tttgttcttt 263641 tcctacatgg cgatcaggaa tgcggacaag caggatgcgt aaacaaaggc gcccaatatg 263701 tataaaaggc cgatgctgtc agcaccggcc tttccattat gagtctgttc ttgtttcaag 263761 ataatgcttc ttgccaatct ctttgctcat catatagaaa tggaagcaat attcaccgat 263821 tgccatgacg atcgcgccga ataaagccgc caatgcaact tcaccgccag tcatccccat 263881 agaaagcggc atgcccatca gccagatcac gagaaaggcc aaaccaaaat cagccaaagt 263941 tgcaatcata ttattccatt tcggcaatac ataaagatcg cccagcaaat aagaaataac 264001 ccctaacaca atcgtcatta gcagcgtatc accaaacgtg aaaccaaagc ccagaccaag 264061 caccagatac aacacaataa tcgtcataat acctttaata gcgagcgctt tcacatgtgt 264121 cattacaatt cctccttttg tcatttgatt tgttatgtat aattcctcaa atgtaaaaag 264181 ttaaacctta tttcttttcg gaggcgggtg caaatctgct ggggagaggt caatgatgtg 264241 aatccaggaa ttgaggctgc ggcgcttcga cagcggaaac gtgaagcttg tactgcaccg 264301 gacgctgctt tgatgcccaa cagcccatta tgtttgctgt ttttagatga ataaatttaa 264361 aaacttctcc tgtccctccg tcatcacttc tgaagtaatg aaatatgatg aaaagagatc 264421 aaggggaggt gacgtgatgg cggtcgtgag agcaacgagt gcggatgtcg atttgatggc 264481 aaggctgctc agagcggaag cggaaggcga aggcaagcag gggatgctgc ttgtcggcaa 264541 cgttggaatt aatcggctgc gggcgaattg ctcagatttt aaaggcctcc gcaccatcag 264601 gcagatgatt tatcagccac acgcgtttga ggctgtgact catggatatt tttatcaaag 264661 ggcgcgagat agcgagcgtg cccttgcacg ccggtcgatt aatggtgaaa ggcgctggcc 264721 tgcaaaattt agtttatggt acttcaggcc gcagggggac tgtccagccc agtggtataa 264781 ccagccgttt gtggccagat ttaagtcaca ctgcttttat cagccgacgg cggagacgtg 264841 tgaaaatgta tataacacat tttagagaca ggacaccgtt caaattgaac ggtgtttttc 264901 tttgaaaaga tgcaatgcaa aatattcctg tgagataatc aaagaaaaaa gagctgacgg 264961 agatgacaga atggcaacaa ttgacctgca aaagaaaagt gtaaagatcg tactggagaa 265021 aaagcagtta acgaaggtga cggctcgtgt tggactggtt cttgatatta cgggatcgat 265081 gagaccgctc tacaaaaacg ggacggttca aaatgtggtg gagcggattt tggcagtggc 265141 tgatcagttt gatgataacg gtttgctgga tgtatgggtg tatgataatg aattttcccg 265201 attaaagcca gtttcagaaa aggatttttc gggctatgtc gatcgtgaaa ttttaaataa 265261 tgaccgcttg cataaattcg gcagaaatga tgagccgcca gtcatgaagg acgtgctgcg 265321 caaatatgtt acggaggaac cgagctcgta tcctgctttc attgttttta tcaatgacgg 265381 gggctgtaaa aagtcaatca aaccgataat tgaagcttct tctgataaac cggtgttctg 265441 gcagtttgtc ggcatcggaa acggaaactt tgattttctc aataaactgg atacgttaga 265501 agggcgtgtc attgataaca cgaacttcct gcatatcgaa gagattgacc gcatttctga 265561 tgatgagctt tatgatgctc tgcttgctga atttccattt tggctgaaag aagcgaagga 265621 aaaagggatt gtaagagaac aagagcctcc tgctgaaaag ccgaaaaaga agggcttttt 265681 cagcagattg ttttcgaaat aactgataaa gagcactgag tcattctgcg aaatggctcg 265741 gtgtttttgt ttttttaaga tcatgtgaag aaaaataggc cgaatgggcg gcttgcaaac 265801 gacaggatat gcagaaaacg cgtcattcag ccagctttcg gcatgtttca gcagcaggct 265861 tgtgagggaa gacctgtttt taatgttcag cgcttacaat cagttcacac ttcttcacag 265921 tcgtttaaca atgatttcct ataatggaga cgatcaatga ggagagaggg gatcttgaat 265981 ggcatacgac agtcgttttg atgaatgggt acagaaactg aaagaggaaa gctttcaaaa 266041 caatacgttt gaccgccgca aatttattca aggagcgggg aagattgcag gactttctct 266101 tggattaacg attgcccagt cggttggggc ctttgaagta aatgctgcgc ctaacttctc 266161 aagctatccg tttacattag gggtagcgtc aggtgatccg ctttctgaca gtgtcgtgct 266221 ttggacacgt ctggcaccag atccgctgaa tggcggggga atgccgaagc aagcagtgcc 266281 tgtcaaatgg gaggtcgcaa aggatgagca tttccgcaaa atcgtaagaa aaggcactga 266341 aatggctaaa ccaagtcttg cccattccgt tcatgtggaa gcggacgggc ttgagccaaa 266401 caaagtgtac tattaccgtt tcaaaaccgg ccatgaacta agccctgtcg gaaaaacaaa 266461 aacactgcct gcccctggcg ccaatgtgcc gcaaatgacc tttgcatttg cttcctgcca 266521 gcaatatgag cacggatatt atacggccta caagcatatg gcaaaggaaa agcttgatct 266581 tgtcttccat ctcggtgatt acatatatga atacggccca aatgaatatg tatcaaaaac 266641 aggcaatgtc cgcacgcaca acagcgcgga aatcattacg ctgcaagact atcggaaccg 266701 tcacgctcaa taccgttctg acgccaatct taaagctgca catgcggcat tcccttgggt 266761 tgtaacttgg gatgaccatg aagttgaaaa caactatgcc aataaaatac ctgaaaaagg 266821 acagtcggtt gaagcattcg tgctccgccg cgcggcagca taccaggcat actatgaaca 266881 tatgccgctc cgcatttcct ctttgccgaa tggcccagat atgcagctgt accggcactt 266941 tacgtacgga aacctggcgt ccttcaatgt gcttgatacc cgccagtaca gggacgacca 267001 agccaataac gacggcaata agccgccttc tgatgaatcg cgcaatccga atcggactct 267061 gcttggaaaa gaacaggagc agtggctctt caacaatttg ggcagctcga cagcccactg 267121 gaatgtgctg gcgcagcaga ttttctttgc caagtggaat ttcgggacaa gcgcaagccc 267181 gatctacagc atggattcgt gggacggcta cccggctcag cgcgaacggg ttatcaattt 267241 cattaaaagc aaaaatctga ataatgttgt cgtactgaca ggtgatgtac acgcaagctg 267301 ggcatcgaat ttgcatgtcg atttcgagaa gacaagttca aaaatattcg gagccgaatt 267361 tgttggaacc tcgatcactt ccggagggaa cggagcggat aagcgagcgg atacggacca 267421 aattttaaaa gaaaatccgc acatccagtt ctttaacgac tatcgcggat atgtccgctg 267481 tacagtgacg cctcaccagt ggaaagccga ttatcgggtg atgccatttg tgaccgagcc 267541 gggcgcagcc atttccacgc gggcttcatt cgtttaccag aaagaccaaa ccgggttgag 267601 aaaggtatca tccacaacaa tccaaggcgg ggtgaagcaa tccgatgagg tcgaagagga 267661 tcgtttcttt tcgcacaaca aagcccacga aaaacaaatg attaagaagc gtgcaaaaat 267721 cacgaattaa ggagtggaaa ttatgttttc aaacattgga ataccgggct tgattctcat 267781 cttcgtcatc gccctcatta tttttggccc ttccaagctg ccggaaatcg ggcgtgccgc 267841 cggacggaca ctgctggaat ttaaaagcgc cacaaaatca cttgtgtctg gtgatgaaaa 267901 agaagagaaa tcagctgagc tgacagcggt aaagcaggac aaaaacgcgg gctgaatgct 267961 gatgaggcag acaccgggtc tgcctctttt tttatgaaag ggagggcttt tttgaatgga 268021 taaaaaagaa acccatctga tcgggcattt agaagagctt cgccgccgga ttatcgtcac 268081 ccttgcggca ttttttctat ttctcatcac ggcttttttg ttcgtacagg acatttatga 268141 ctggctgatc agggatttgg atggaaagct ggctgtgcta ggaccgagtg aaatcctctg 268201 ggtgtatatg atgctttccg gcatttgtgc cattgcggct tctatccctg ttgccgcgta 268261 ccagctgtgg cgtttcgttg caccggcgct gactaaaacg gagcgcaagg tgacgctcat 268321 gtacatacca ggtttatttg cgttgttttt ggcgggcatc tccttcggat actttgtctt 268381 gtttccgatc gtgctcagct ttttgactca tttatcctcc ggccactttg aaacgatgtt 268441 tacggctgac cgctacttta ggtttatggt gaatttgagc ctgccgttcg gcttcttgtt 268501 tgagatgccc ttggtggtga tgtttttaac aaggctgggc atcttaaatc cttacagact 268561 ggccaaagcg agaaagcttt cctattttct gctgattgtc gtgtccatat tgattacacc 268621 gcctgatttt atttctgatt ttctcgtgat gatcccgctt cttgtcctgt ttgaagtgag 268681 tgtcacccta tcggcgtttg tctacaaaaa gaggatgagg gaagaaacag cggcggccgc 268741 ttagtgcagc gtaccacccg gtgacttcac atcctcatca tattgtgcgg ccgtaacagc 268801 ggcgattctc aatgcccgga caatcgtgtc caggctgagg ctcggcgctg ttttgtcgat 268861 tgtttgctgc ggaatgtaag gaatatgaat aaaaccgccg cgaatgtgtg gggatgtccg 268921 gctaatgtga tccattaacc cgtagaacaa atagttgcat acaaaggtcc ccgctgtgta 268981 ggaaaccgca gctggaatgc cgtgttcctt catcttagca gtcattcgtt tcacgggaag 269041 ccttgtccag taagcggcgg gcccatctgg agaaatctct tcatcaatcg gctgatgtcc 269101 ttcgttatcg gggattcgcg catctgcaag gttgattgcc actcgttccg gtgtaatctg 269161 catccgtcct cctgcttggc cgacacaaat tacgatatct ggctgatgtt tttgaatggc 269221 ttggcgcaga gtgtccagag cggatctaaa gacggttgga atttgttccg ctgtaataat 269281 ggcttcttct gtctcgaagc cattaagccg tttcgccgct tcccatgatg gattgacggt 269341 ttctttgtca aaagggtcaa agcctgtgat cagcactttt tttctcattc tcccatctcc 269401 tttttctttt attctattgt ttatttatgg gtttttcatc aaaataatgt aaaggagtga 269461 atcataatgg agcatttgcc ggagcagtat cgccagttat tcccaacctt gcagacgcat 269521 acgatgcttg ccagctgttc tcagagcgca ttggcagagc ctgtatcaag ggcgatccag 269581 gattattatg atagcctgct gtataaaggg acgaactgga aagaagcgat tgaaaaaaca 269641 gagtttgcga gaaacgagtt tgcaaagctg atcggggctg aaccggatga agtggcgatt 269701 gtgccgtcag tttctgatgc actggtttct gtagcatcgt ccttaactgc atttggaaag 269761 aagcacgttg tatatacaga tatggatttt ccggcggtgc ctcatgtttg gcaggcacac 269821 tccgattata ccgtatccgt cattccatca atagacggcg tgctgccgct tgaacaatat 269881 gaaacgcata tttcggatga aacagtactg acgtgtgttc ctcacgttca ttatcgtgac 269941 ggctatgttc aggatataaa agcgattgcc gagatttctc agagaaaggg ctctttattg 270001 tttgtagatg cttatcaatc agccgggcat attcccattg atgtgaagga atggggcgta 270061 gatatgctgg cagcaggcac ccggaagtat ttgctcggca taccgggtgt ggcgtttctt 270121 tatgtgagaa aggagctggc tgacgcactg aagccgaaag catcagcttg gttcggaaga 270181 gagagcggat ttgatggggc ttatgcaaaa gtcgcgcgcc gttttcaaac gggcacccca 270241 gcttttatca gcgtatacgc agctgcagcg gctttatcgc tgctgaatca tattggggtt 270301 tctcatatca gggatcatgt gaaaacgatc tgtgccgatg cagttcaata tgccgctgaa 270361 aaaggcctgc agctggcggc ggcacaaggt gggattcagc cgggcatggt tgcgatccgg 270421 gatgagcggg catcggaaac ggcggggttg ctgaagaaga aaaaagtgat ttgcgcgccg 270481 cgggaaaatg ttatccgtct cgctccccat ttttataata cgaaggagga aatgcggcac 270541 gcgattgatg aaatcgcggc gaaaacgatc cacaagtaaa catgaaaaag cccctgaaca 270601 ctagtcaggg gcttttcata ttaatgatct actttaacgc gtttcataaa gaaagcgcca 270661 attaaaccga taatggcaac aatcattgca aacacaaatg cgtgctgtac gcctgctgtc 270721 aaagcttgcg ggatgactgc cggatcggca gggtttttaa ctgtactcat ataatcatgc 270781 tggcctgcag ccataatgct gaccgcaacc gctgttccga tagcgccggc catttgctgc 270841 agcgtgttca taatggcggt gccgtctgga taaaattcac gcggcagttg gtttaaaccg 270901 tttgtctgtg caggcatcat gatcatagaa atcccgatca tcaagcaggt gtgcaggatg 270961 ataatcagca cagctgttga agtggtcgtg acatttgaga agaaccatag tacaacggtg 271021 acaatcacaa atcccggaat gacaagccat ttcggcccgt atttatcgaa caagcggcct 271081 gtaacagggg acataaatcc atttaaaata ccgcccggca agagaacaag accagatgca 271141 aatgcagtga ggactaagcc gccttgcaga tacatcggca gaagcagcat agatgacaga 271201 atgaccatca tacaaatgaa caccatgatc acacccaaaa taaacatcgg gtatttgaac 271261 gcacggaggt tcatcatagg ctgcttcatt gtcagctggc ggattgaaaa taagataagg 271321 ccgacaacgc cgacaatcag cgacacgata acagtcgggc tggaccatcc cccggagcct 271381 tcacccgcgt tgctgaatcc gaatacaatg ccgccgaagc caatcgtcga caggatgata 271441 gacaatacat cgattttcgg ctttgtcgtt tcagatacat tttgcatata tgcgataccg 271501 aaaacaagcg ccagcacaag gaatggaaga gagatccaga aaatccagtg ccagttgaga 271561 tgctccagaa ccaatcctga gaaagttggg ccgatggcgg gcgcgaacat aatgacaagc 271621 ccgatcgttc ccattgcggc accccgttta tgaggcggga aaatcaccaa gattgtgtta 271681 aacatcagcg gcagtaaaag accggttcca agtgcctgaa cgatccttgc cgctaataaa 271741 aacgagaagc tcggcgcaag cgccgcaatg aatgtaccta aaattgaaaa gataagtgac 271801 acggtaaaaa gctgtcttgt tgtgaaccac tgcaacagca gtcctgaaac aggaacaagg 271861 ataccgagta caagcaggta gcccgtcgtt aaccattgga cggttgccgc tgtaatgttc 271921 aattccttca taaggtcggt taacgcaata ttcagcgctg tttcactgaa catgccgata 271981 aaaccggcca acagcaagga aatcataatc ggcatcactt tgtattgctg agatgcttta 272041 gctgttgttt ccaaaatcat ttcccctctc tatcaactgc atgtagtatg tcgttttttt 272101 tatctcttca gcaggtcagg aatgcagctg gagatatgaa ggagcggcgt actgtttttt 272161 gccgtcaaag ataaaaggat gccgccttca atcatcgcgt taaccacagt gctggcttct 272221 tttgcacggc tctcgctgca gccagtctgc cgcagttttt cctcatacac agaggcccat 272281 tctttgtagg cttcatgaca ggcttcgcgc aacggttcgc ttttcaatga cgtctcagcc 272341 gctagcaagc ccacaggcaa gccttcaatg tcttccgtac atgaaaactg gcaggagagc 272401 tccttcaaaa aggcttgaat gccttccgct ggatcggtgc aggcttccat gcagtccgcg 272461 attttctgac ggatatactc cttcatctca ttcacggctt cgatcgcaag ctgttcttta 272521 cccccgggaa agtggtagta aagagagcct ttaggcgcgc cgctttcctt tataatctgg 272581 ttcagccccg tgccgtaata cccttgcagc tgaaaaagcc gggtagctgc cgaaaggatt 272641 ttctcacggg aatctccata actcataaca ttcccacctt actgaattgc aatcaaaaat 272701 atagtgactg gtctattatc ttgattcaat catcaattgt caagaaaaat tcattgtatg 272761 aaaagacaaa aaaagaagga tatgacaaca aaaaatactg agagaaaagc tgactgatct 272821 tttgactgaa tagataaaat gtacaatgat taatcatcat atggatgtaa ggagagaaat 272881 agatgaaaaa acaacgaatg ctcgtacttt ttaccgcact attgtttgtt tttaccggat 272941 gttcacattc tcctgaaaca aaagaatccc cgaaagaaaa agctcagaca caaaaagtct 273001 cttcggcttc tgcctctgaa aaaaaggatc tgccaaacat tagaatttta gcgacaggag 273061 gcacgatagc tggtgccgat caatcgaaaa cctcaacaac tgaatataaa gcaggtgttg 273121 tcggcgttga atcactgatc gaggcagttc cagaaatgaa ggacattgca aacgtcagcg 273181 gcgagcagat tgttaacgtc ggcagcacaa atattgataa taaaatattg ctgaagctgg 273241 cgaaacgcat caaccacttg ctcgcttcag atgatgtaga cggaatcgtc gtgactcatg 273301 gaacagatac attggaggaa accgcttatt ttttgaatct taccgtgaaa agtgataaac 273361 cggttgttat tgtcggttcg atgagacctt ccacagccat cagcgctgat gggccttcta 273421 acctgtacaa tgcagtgaaa gtggcaggtg cccctgaggc aaaagggaaa gggacgcttg 273481 ttgttcttaa cgaccggatt gcctcagccc gatatgtcac caaaacaaac acaactacaa 273541 cagatacatt taaatcagaa gaaatgggct tcgtcggaac aattgcagat gatatctatt 273601 ttaataatga gattacccgt aagcatacga aggacacgga tttctcggtt tctaatcttg 273661 atgagctgcc gcaggttgac attatctatg gataccaaaa tgacggaagc tacctgtttg 273721 acgctgctgt aaaagccgga gcaaagggga ttgtatttgc cggttctggg aacgggtctt 273781 tatctgatgc agccgaaaaa ggggcggaca gcgcagtcaa aaaaggcgtt acagtggtgc 273841 gctctacccg cacgggaaat ggtgtcgtca caccaaacca agactatgcg gaaaaggact 273901 tgctggcatc gaactcttta aacccccaaa aagcacggat gttgctgatg cttgcgctta 273961 ccaaaacaaa tgatcctcaa aaaatccaag cttatttcaa tgagtattga agaaaagaag 274021 gcgaataagc cttctttttt ttggcttttt aggaccaata atgacctctg aatcttaaaa 274081 tttctttaaa aataagccaa aattaccctt tacttaatta atttggtaac gtaatataat 274141 tggagaattt gttacaaaaa aaggaggata ttatgaaatt tgtaaaaaga aggatcattg 274201 cacttgtaac aattttgatg ctgtctgtta catcgctgtt tgcgttgcag ccgtcagcaa 274261 aagccgctga acacaatcca gtcgttatgg ttcacggtat tggaggggca tcattcaatt 274321 ttgcgggaat taagagctat ctcgtatctc agggctggtc gcgggacaag ctgtatgcag 274381 ttgatttttg ggacaagaca ggcacaaatt ataacaatgg accggtatta tcacgatttg 274441 tgcaaaaggt tttagatgaa acgggtgcga aaaaagtgga tattgtcgct cacagcatgg 274501 ggggcgcgaa cacactttac tacataaaaa atctggacgg cggaaataaa gttgcaaacg 274561 tcgtgacgct tggcggcgcg aaccgtttga cgacaggcaa ggcgcttccg ggaacagatc 274621 caaatcaaaa gattttatac acatccattt acagcagtgc cgatatgatt gtcatgaatt 274681 acttatcaag attagatggt gctagaaacg ttcaaatcca tggcgttgga cacatcggcc 274741 ttctgtacag cagccaagtc aacagcctga ttaaagaagg gctgaacggc gggggccaga 274801 atacgaatta atgaaaaaca aaaccttgaa gaatgctatt cttcaaggtt attctgcttt 274861 cagcacaatg gttttcgcag ccatatcatg aacggtttgt tttttcttcg taaatgcggc 274921 agtcaaatag atcaggcggg agaacacatg cacccacgct atcaggtaac ggacaatggc 274981 ttgcgggaag gatatttttt tatatgtttc gtccctcacg atttgcagcc cgatgatttt 275041 tttgcccagt gtgcccttcc aatttgtcag cggcatcagc aaagggtaca caatcagcat 275101 caatatggcg acaataatga caccggcgga cccatcgcca aacgtaaatc cggctgccaa 275161 aatcactgct gcggcaatga ttacatcaag taaaagagcg caggcgcgca gcatgaaacc 275221 agctagttcc aatagaaaca ctccttaaaa tgttaaataa acacctaatg attgtaaaaa 275281 agaagggcct aaagtgggaa taggtgataa gccttaaatc acaaaagttg gtgaaaatgt 275341 cataggtaaa ttggcataat cagccagctt atcacattac caaattcttt tttagcccga 275401 aaccaagccc tcagaagtta tttttgttaa aatagaaaag ttacaacaga attcggaggg 275461 tttattgtgg gaaaagtgaa acgaaatgcc ccttgcccat gcggcagcgg caagaaatat 275521 aaaaaatgct gcggaagtaa agttgtcgac ttcccggcgg aactagcggc aaaagaagcg 275581 aaacaaattc aggaagactt agtggagtat gccttcacag tacatagaga aagcatttca 275641 ggctttatca accagcatga ttttctttct gctatggaca gacagacgaa agacatcagc 275701 gtatttaact taggaatctg gggaatcttc ttccacccgc ttgctggtga gaagacaatc 275761 ttcgaagagt accttcagaa aaaaggcgat tcgatcactc gtccgaaaac gcgtgagatc 275821 gtagaatcat ggcagagcat gacgcctgct ttattgctgc tgaaggacct gaaggaaggc 275881 atcattcact ttgaagatgt cattacggca aaacaattcg aagtggaaat ggacgccagc 275941 aatcaagacc ttcctccagt gggaagcctg attcttggat acccaatcca cgaagcggaa 276001 aaagcagaat tcttcatgca gttcacgatc ttcccggtga agagaacaga agcgctgatc 276061 agcaaggtga agaaatatgc ggatgccgct gtgaaggacg gcaaaacgcc ggaggacttc 276121 atgaagcagg aattcaacaa cgttctgttc gcgttgttag ctgagaaaga tgaagagcca 276181 caagcagaga aagcggaagt aagcactgtt gagtgggcaa acgacttgga gaaagaaacc 276241 gctgcggcta ttgaagaagg catgagcggg gaagagtatc cgactgaatt gatcccagct 276301 gttattgaca tctggaaaac attctgcgag aaaaaatcac ctgtcatcag aaagccggaa 276361 gcttttgcgg cggcagttga atattatgta aacgcaattt ctcttaacgg cgcgtccgtt 276421 tcccaggcta aactggcgaa aaaatacggc gttagcgcat caacgatttc cagccgttac 276481 aaagaaattg aaagcacgct gcaagatgaa gcagatcgtt ttgcacaagc gttatcctca 276541 taatggaaaa aaccttgaaa agccaggctt ttcaaggttt ttttatttct gaaacggaat 276601 tttgatttct aaccggaaga tggggtggcg gtaggtaaaa tccagcctgc caaaagcgcc 276661 cttcaccagt ttttgaatga tatatgtgcc catgccttca tgagcgccgt ttttcgttga 276721 gcggccaaac gattgataaa ttgtatcgag cacttttggg tccatcccgg gagtgctgtt 276781 ttcacaagtc agtacataaa gcccgctgcg cagtgaagtc tccagtttaa tctctgcttt 276841 ttctcgggcc tccgccgcgc tgtcgagcgc attttctaat atgttgccga ccaagctgac 276901 ctgatcagca ggcgaaaacg gaagggaaga aagcggtgta tgcatatgca gcgaaacact 276961 cacattcgag gcgcgggctt tttctaaaaa atcataaagc acccctgcaa cgtacgcgtt 277021 ctctcctttc aaaaaacggt catattggct gtattgatcc gcccagtttt gaatatatgc 277081 ttgtgtatct gccttgggct gagctgattt gattgcagtg atatgtttca ttgtgtcatg 277141 attccggctt ctgacatcaa tcagcatttg attggcgtgc tgttcagctt gagtcagctt 277201 atcaatttga tcagaaagcc ttgcctgcaa agcagactgt ccgatacgga gcccttcaca 277261 ccctgcaaat atcgcgatta cacataatac cggcatgatg tctgtgccaa tcaacaccac 277321 tcccaccgac atcacttgaa tcaccgcaat ccacgcacaa agccctgagg aacagtgttt 277381 ccacacccgc ttcgtattcc aaatgtacaa tcctgcagca gctgcgccta aagcagcggc 277441 gagccaagag gcggctgtgc tgtgtgaaaa agcagcagct ccctgataac atatgaaact 277501 aaataaaatc agataaagac attgaaaaag ggtaatcacg tactaaactc ctcaaaaata 277561 gtagttttga aaataatcaa gctgctgctt agtgatcatc gcttttttag acgttccctc 277621 aaaggaaact gtgaatgaat gcttggtata agcggaaaaa tgctttatgt aatgaatgtt 277681 gataataaag gaacgatgcg aacgaagaaa atctttttcg ggcaggtcgc ctttaatatc 277741 atttaatgtt tgatacgttt gcacctcttc ggcggttgtc acaatcgtcg tcgaacgtcc 277801 cgtccgttct gcgaaaataa tatccttctt ttgcaggacg tgcatttcag acttttgctt 277861 tatcaatata cgcccattca aactcgtttc cgttttcttt ttcaagtacc ggtcgaagga 277921 agcggccaga cggtcggcat agtacggctt cataatataa tcatggacgt tcaggtcaaa 277981 ggcgtgaacc gcataaccgc cgtggccggt aacaaaaatc acatccacat caagtgaatg 278041 ggatttgatc aaatcagcaa gctcgtagcc agacatatgg ggcatctcga tatcggcaag 278101 cagcagatca atgtctccgt tctttacccg cctgtaggct tccttcgctg aatcggtgga 278161 aaagacaatt tcgacgtcct gcattctgga cacgatcgct tctaacttct ctaaatctac 278221 tcgataatca tctacaagtc cgacttttac cattatcatt cccctagtta catagaatca 278281 tctttattct atcccatttc acgacataaa aagaactctt cgcgacaact ttatccaact 278341 aatccagctt ttcgtatata gtcattacta gaaataaaga taagggagat tgtgacatga 278401 ttacactgac cgattgcagc cgcaggtttc aggataagaa aaaagtagtc aaagcggtgc 278461 gagatgtaag cttaacaatt gaaaaaggag aagtcgtcgg cattctcgga gaaaacggtg 278521 ccggcaaaac gacgatgctg agaatgattg cttccttgct tgaaccatca cagggtgtaa 278581 tcacagtaga cggctttgac acggtcaagc agccggctga ggtcaaacaa agaatcggtg 278641 tcttattcgg aggagaaacc gggctttacg acaggatgac cgctaaagaa aatctccaat 278701 acttcggcag gctgtatggg ctgaaccgcc acgagatcaa agcaagaata gaagatttat 278761 cgaaacggtt cggcatgcgc gattatatga accggagagt gggcgggttt tcgaaaggca 278821 tgaggcagaa agtcgccatt gccagagcgc tgattcacga tccggacatc attttatttg 278881 atgagccgac aactgggctt gatattacgt caagcaacat cttccgcgaa tttatacagc 278941 agctgaaaag agaacaaaaa acgattcttt tctccagcca cattatggag gaagtgcagg 279001 cgctctgtga cagtgtcatc atgattcaca gcggagaggt gatttaccga ggggcgcttg 279061 aatcactata cgagagcgag cgcagtgagg atttgaatta catctttatg tctaagcttg 279121 tcagggggat ttcttaaatg ctgagccata tttataaaaa agaaatgatc gacgctttac 279181 gcgacagaaa aacgatatta ctcacaatct tagtgccgat gattatgatg cttggacttg 279241 tcttttttta tgaaagcatg ctgtccgaca aaggggagca gtacacgctg gctgtcggcc 279301 attcgcttcc gcccgcactg gaaagcaagc ttaatgagat tgacgaaatc agcgtaaaaa 279361 catttgcaaa gcctgaagag gcagttgatg aaggaaaagc agatgcctat ctgaacgtcc 279421 cgaaagagtt cgactcatat gtcaacagca tgacaccttt taaggttgat gtttacggca 279481 attcaatcga tcaagggtcg tcaaatgcca tgcagcttgt gcagtctgcc ttagatcagt 279541 acaaaaatga aattgtgcag caacgtttaa caaataagca tattgatcaa tcggtgatcc 279601 agccgtttac aattcagcaa aaggaagcgg atgaggagaa agggacttcc gctattatgc 279661 tttccgccat tctgcccatg ctgattctga cttccattgt ttccggcgca atgccgatcg 279721 ctcttgatat catggccggt gaaaaggacc gaaagtcaat cgaggcgctg ctattaacgc 279781 cagtcagcag aaacaaagtg ctggtcggca agtggcttgc ggtttccact tttggcgtgg 279841 cttcaggtgt atttgctttg gtgtttttga ttttgtccac cgtgttattt accgaaaatt 279901 taaaaacggc cttccagctg ggagatcata tgtggagtgt aatcggcgct tcagccttaa 279961 tcattgtgct ctctgcattg ctgatatctg cgatggagct tttcatcagc atcatgtcca 280021 gctcggtaaa agaagcgcaa agttatatgt ctctcgtcgt ctttctgcct gtgttcccga 280081 tgtttttcat cttcagcaag gcaccgaacc aatttgactt atcatacttt ctcatcccgt 280141 ttctgaacct gcatgcgtta tttaaacagc ttttattcgg gatggttgac ccggctacca 280201 ttttgtctac gtcaggaacc atcgccgtgc tcatcgccat cttcttttta ctagccagag 280261 cctgcttcct gaaagacaaa tgggttcttc caaaataaac ttgcgaaagg agaaatacac 280321 tttctccttt ttgtatatcc tgaaaaaaga aggaaaatag aaaaaggata tctaatacaa 280381 aaagtgaccc tgcactattt ttcatcaaaa ttggtttcaa aggagaagga acaatggatc 280441 aaacacgtac actcggcaaa acgaagctga aggtgaagcg gatcggattc ggcgcgaatg 280501 cggtcggcgg gcataatcta tttccaaatc taaatgatga aacagggaag gatttagtgc 280561 gcacggcatt ggatggcggc gtcaatttta tcgataccgc ctttatatat ggattggggc 280621 gatctgaaga attaatcggc gaagtcgtac aggaacgcgg cgtgcggaat gagctcatca 280681 tcgccaccaa aggagctcat aaagaagtgg acggcagcat tgaattagac aatagccggg 280741 agtttcttcg cagcgaggtg gagaagagcc tgaagcggct gaaaacagat tacattgatt 280801 tgtattatgt tcactttccg gatggaaaaa cacctctcgc tgaagtggcg ggcactttga 280861 aagagctgaa ggatgagggg aaaatcaaag cgatcggcgc ttcgaacctc gattatcagc 280921 aattgcagga ttttaatgct gacggctatt tggaggtctt ccaggccgaa tattctctca 280981 tacagcgtga tgccgagaaa gagcttcttc catactgtga aaaacaaggc atctccttta 281041 ttccttactt tccgcttgcg tccggactgc tgacaggaaa attcacgcaa gacacagtct 281101 ttgatgattt cagaaaggat aaacctcaat ttcagggtga aacgtttatc cacaatctca 281161 aaaaagtaga taagctgaaa gcagtagcgg aggaaaaaca agcggatacg gcacatgtcg 281221 ccttggcgtg gctgttaacg agaccggcga ttgatgccat tattccagga gctaaacgac 281281 cggagcaatt acaggataac ctgaaaacct tgaacattga actgaccgaa gatgaagtga 281341 atttcatcag cgacattttc aaataaaaaa ggaaatagcc gtcatggcta tttccttttg 281401 gtgttttatt ctttgatgaa tgcttcgact aattctgctg ctctgtaatc atccatatca 281461 agctgccatt ggtcgatgtc atttttcttc attttcactt caactgtttt ttcagatgaa 281521 gcaggtccaa gctttttgaa ttcctcagga tagacttgaa gcgcgtattt cactgcctct 281581 tcatagctgg cactagagtt tttactgtag tagtctttca ctttgtcttc gatgcggtct 281641 gaaagagaag atgcatctac aggtttaact gtggcttcaa caattgcttc gtctttagag 281701 attgaagtcg tttttgcttg aatggaagag tttttgctta atccctcttt aatgccgttc 281761 acgatattat caagcgcttt gctgtccgca tatgtgctgg aaaggccgga agctgagaga 281821 taaccgtctt tggctgattc attaaaatca tttacaattt catttttgtt agcgccggtg 281881 attttttcga aatcggcgtt atctttgccg aaaagaagga catcaacata agctgataac 281941 gcttttgcag aatcttggag cttatctgcc gtcgccagga tttttttgtc ttttccgtca 282001 attttaaaag taactgattt tggcttttta tcaccgtaag attccggcgt atagttaagc 282061 tcgtattgct tgcctttatc tacaacgaag aaaagatttc cttcaacgga tttgtcagcg 282121 ttaatcgtgc tgccctgaag cttttcgcta tagtcttcag ggtctgtgtc agacattttg 282181 gtatcacctt gatacaatgt gaaatccata ctgtctacat tcagcgggtc ttttcctgtg 282241 tttttcaccg cgacattgac ttttaacaca agctggtcat ctgaagtgga cttatcatat 282301 ttagacggaa gtgtgtaaga gacatccttg attttgactt gagctatatc tgagcttttt 282361 tctgtttctg attctttctt ctccgcgctt gttttgctgc cggaacaagc agctgtaaac 282421 atcatcagca gaagaattag gaaaacagcg tacgtttttt tctgaaacat tcatttttcc 282481 tcctcaaatg gtttaggaaa ggggagtctt ttgtctttga gaaatggatc tttttgaatg 282541 gattagcatc atataaccaa aaaaatcagt tcttttctca cggttttcac cggattttct 282601 ggaaactccg ccctcctttg tcatgaatgg acctataaaa agttacaacg gaattaattt 282661 taagattatt agcttttata ttgaataggt tcatcatcct atttttggtg aaaaatgttc 282721 tggtaaaact ggtaaactca gaaaactgtg tattttagac tattactttt tgattagttg 282781 gagggaactt aagaaggatg aaaggggccg cctttgtgaa gaaagaggga ctgaaacaaa 282841 aagcactgga aatcggccgg gtgccgacac acttaaaact ggaaattgaa gattatggcg 282901 gtgatgataa aagagctcat ttttgttggg cagatcctca ggatgagaat accggcatta 282961 tcgtggagct tggaccggac ggagagctgg aatccctttc ccgtgatatt gagcctgaaa 283021 gcggagaaag gctgtctgag gagaaactag aggatatcat gcgccaattt gtcgagactc 283081 atcatccggg ggcactctct gcctttgttc gtgaagaaaa tgaccgtgca tacggcgata 283141 aagtgagatt ttcatatgtt caaatggagg ctgggcttcc tctccccatg agcggattta 283201 tggctgatgt ttccttatca ggtgagattg tttacttccg ttattacggc gaagcgggca 283261 gcatcatcaa gccaaagcgg gtcgcggatg ttgaagaggc acttgccttt atcaagaagg 283321 acgtggagtt cgaccttttg tttgaggttc tccatcgttc tgtttacaaa aacggagatg 283381 atcagccgca tttggtgtac gagcctgaag gtagggcgat taccgtacct gcggatttgg 283441 ttcaagaaga acaagcagtt gatgatgacg atgattacag ggagccggag agctttcctc 283501 tccctttatt cgagggcatc cgcgaaaagg ccgatcctga cagcatgatt ggtattgaaa 283561 atgggtttgt caaagagcgg gaagcggatt tgggagatgg gagaattgga atcgtttggc 283621 ggaatccgga tgaccctgtg tatcagccgg cggataaaag catggacagc tggtttaagg 283681 gacggactca tcaagtgctg aaaaccatct ataacaaaga aaccggaaaa ctcgaaggcg 283741 tcatgtcatt tatggagaaa aaagggccgc tgacagtaac cttggcagag tgtgaaaaaa 283801 tcgcgcttcg ctttctattt gctttatttc cgaatgccga tcaatatttt aggatcagat 283861 acgacgaaaa agatgaagaa gaaaacgcag tcgctggttt tacgtttgaa gcgcattgtc 283921 acggagttcc gctccgattt gggcagatca gaatttgtgt cagccgccag acagggtata 283981 tcaccgttta tatgggaccg gatattgacc caaataagct ggcaaccatt gatcctgtgc 284041 cggctatttc agttgaacaa gccaagtcta tcttttggca gcattttaaa gttgagcttg 284101 gctgggaaag agagtacggg gatgatgaag aacacagcta ccggctcgtc tataagccgg 284161 tgtatccgca ttttatcgat gcacatacag gggagcctgt cttcagcata tggtgaaaca 284221 gccaaaagtc acgcaattgc ctcagatata gaagagagta tgtgatgaaa gtaacagaaa 284281 gaatctcaaa aaacaatgac aataatagaa aaggaccttt cttcacttta aatgaagaaa 284341 ggtcttttta tataataaac aggattctct ttgtcgtaga ctctttgaaa gggatgactt 284401 cattggttaa taaacagctg aaaaagaagg cgcaggagat cggaaatgta ccgacgcatt 284461 atgagcttga gatagaagat tacgaccaaa agcaaaagaa gtacgggcag gcatatttta 284521 tctggaagga ccctaaagat ccggaaaagc acattacagt tgaacttaga aatgacggcg 284581 ccttgctcac cttttcaaca actgtccact ccgagacaga caaaaaactt ccagatgccg 284641 agctgaagct gacggctctt cagtttgccg ctgccaatca tcccggcaca tttatgaatt 284701 ttcattttca aggcaaggaa gaaagggggc agcacatccg gtttgtctat accaaaatgg 284761 agctggggct tccgattccc aattcaggct ttttaattga tatgacacga agcggtcaga 284821 ttgtccactt tctatattac ggggaagggc ataaagccga agttccgacg gaatttgtag 284881 caaaagagaa ggttgtatcc cattacttaa acacaatgtc ttttgagctg atgtacgatg 284941 tcattgatgg cgaacaggaa ccaaggcttg tatatgaacc gattctaccg ggatacagct 285001 atcccgcaga tgtagacgaa attgtgcccg accagcatat cgcagatgaa agaatagaaa 285061 acacggcgcc actgccgccg cttcagaaca aggaagaagt tgatatattt gccttgctgg 285121 gttttacctc tgatatgcag aaagtcagtg aaagagactt tggagaacaa attggaagca 285181 cgtggcgcag gggcgctgcg ccggagcgta aggatttaag cataggaagc tattttgaaa 285241 cgagaaataa aaatacaatc aaaatgaaga cggataaaag aaccggaaaa ttaaaagcag 285301 cgctttcttt tatggactgg cggaacaacc tccaatgctc cacggaagaa tgccaagaga 285361 tagcgcttca atttttgtat gccctctatc cgagagcggc tgagtttttc agggtgaatc 285421 ccgtccgaat tgatgaaaga gggagagtcc gcaaccattt ttctgtctgg tataaaggag 285481 tgccgctgcg gttcggcgct gcccgcatca ttgtcaatcc ggaaactggg ttgattgacg 285541 cttttatggc gcctgatatt gaacctgaac aattggaagc gataaatcac aggccggatg 285601 tttccgctga agaagcgaaa gaagcatttt tagccgcttt tgatgtgaaa ctggaatggc 285661 agcctgattt tacagcaggc agtgaccagc actgcaaact tgtctataag ccggtttacc 285721 cttcctatat tgatgcgcac ataaggaaaa agaaaaggct gtgaggggtg tctagttagg 285781 aatcatctcc aagtgggggt agtccttgaa tcgtttccaa tccccgcccc attcgaaacc 285841 gagtgtctta gcgatctcga caacctccag ccaatctgat tttccgtttt gattgccgtc 285901 atattccata tcccatatga tgctgccatc ctttttttga agggcgaaat caatcgctaa 285961 accatagtta tgatacgatt cccctcctct tgcataggtg acaatattcc ctttttttgt 286021 acgtccctgt ttatataatt catcttgttc cttaaaggac ctgaatcctt cagtaatgac 286081 gacgtcaatg cctttattcg ctgcagcggc tttgagtgca tcggcattct gcttcacaat 286141 cggatgaaga tccgagggga caggcatgtc ctgcaaggcg ttttgagaat gccattcatg 286201 ccgaatataa ctaaaacaaa gatctagaag aaatagaata cataagataa caaatgtttt 286261 tgcgggtaag ttcatatcgg tctcactttc tcaagatgtg ctgaatgtta acgcttttaa 286321 gtgattgact ctctctaaaa gcgaacagct atgataaaat ataacataaa tagtagcagg 286381 aggaaggagg cagaccgatg agagcaaaga ttccatcaga agaagtagca gtaaagctga 286441 atgaatggta caagctcatt cgcgcatttg aagcagatca agcagaagcg ttaaagcagg 286501 agattgaata tgatttagaa gatatggaag agaatcagga cttgctttta tatttttctt 286561 tgatggaatt ccggcatcga atcatgcttg ataagctgat gccggtgaaa gacagcgata 286621 ccaagcctcc gttctctgat atgctgaacg aaattgaaag caatcagcaa aaactcacgg 286681 gcttactgga atactacttt tattatttca gaggaatgta cgaattcaag cagaaaaatt 286741 tcatattagc gattgaccat tataaacatg ccgaggaaaa gctcgagtat gtcgaggatg 286801 agatcgaaaa agctgagttt ctttttaaag tcgcagaagt gtattatcac atcaaacaaa 286861 cgtatttttc catgaattat gcgagccagg cgcttgatat ctatacgaaa tatgaactgt 286921 acggtcgccg ccgggttcag tgtgaattta tcatcgccgg aaatttgacc gatgtgtatc 286981 atcatgaaaa agcactgacc cacttgtgca gcgctttaga acatgccagg cagcttgaag 287041 aagcgtacat gatcgctgct gcctattata atgtcggaca ctgtaagtac agtctgggtg 287101 attacaaaga agcggagggc tatttcaaaa cagccgccgc catttttgag gagcacaact 287161 ttcagcaagc tgttcaagct gtattttcac tgacccatat ctactgtaaa gagggaaaat 287221 acgacaaggc agtagaggct tatgaccgcg ggataaagag cgcggctgaa tgggaggatg 287281 acatgtactt gacgaaattc cgcctcattc atgagctgta tcttggaagc ggcgacctga 287341 acgtgcttac agaatgcttt gacctgctgg aatccaggca gcttcttgct gacgccgaag 287401 atctgctgca tgatacagcg gaacgtttca atcagttgga acattacgag tccgccgctt 287461 tcttttaccg caggctgatg aatattaaaa agaagcttgc cgagcagcgt tttcaatagg 287521 aaatggcaga gaactacagg ttctctgctt tttttgtgct gttttcaact cggaaaaaca 287581 gggtattttc cactgcatag tgagaaacag aggaggatat caagtatgta caaagattta 287641 accggaaaaa cagcgattgt gacagggtct tcaaaaggaa tcgggaaagc cattgcggaa 287701 cggttcggaa aggagaaaat gaatgttgtt gtaaattacc acagcgaccc gtctggagca 287761 gatgaaactc tggaaatcat taagcagaac ggagggaaag ccgtctcagt tgaggcggac 287821 gtgtcaaaag aagaggggat tcaggcgctc ttggacacag ctttagagca tttcggcacg 287881 ctcgatgtga tggtaaacaa ctccggtttt aacggcgttg aggcgatgcc gcatgagatg 287941 agtcttgaag attggcagag agtgattgat gtcaatgtta ccggaacctt tctgggagcg 288001 aaagcagcac ttaaccacat gatgaaaaac aatatcaagg gcaatgtgct gaatatctca 288061 agtgttcatc agcagattcc gcgccctgta aacgttcagt attccacatc caaaggcggc 288121 atcaagatga tgacggaaac gctggcgctc aattatgcgg ataagggaat ccgcgtcaat 288181 gcgatagcgc ccggcaccat tgccacagaa tcaaatgttg atacgaaaaa ggaagagagc 288241 aggcaaaaac aattgaaaaa aatcccgatg aaagccttcg gaaagcctga agaagtggcg 288301 gcagcagcag cttggctcgt atctgaggaa gcaagctatg tgaccggcgc aacacttttc 288361 gtcgacggcg gaatgacact ttatccatct cagcttgaat agaagacaaa acagggggat 288421 tgcgggatga aaacagactg gtggaaggat gcagtggtgt accaaattta cccgagaagc 288481 tttcaggaca gcaatggaga cggaattggg gacttgcggg ggattatttc ccgtcttgac 288541 tacataaagg agctcggggc agatgtgatt tggatttgcc cgatctatcc ttctccgaat 288601 gttgattacg gctatgatgt gacaaaccat aaggcgatta tggattctta cggaacaatg 288661 gacgattttc acgagctgct ggaccaggtg catcagcggg gattaaagct ggtgatggac 288721 tttgtgttaa atcacacctc ggtcgagcat ccgtggttta aagaagcgga gctggacaaa 288781 aacagcaaat accgtagcta ttattattgg cgtcccggca caaagaacgg cccgccgacg 288841 gactggctct caaactatgg atgcccggtc tggcaatacg aagagcacac cggagaatac 288901 tatctccata tgaatgccgt caaacaagct gatttaaact gggaaaatcc cgaagttcgc 288961 caggcggtgt atgacatgat gaaattttgg ctcgataaag gggtcgacgg tttgcgaatt 289021 gatcagctcc atctcatttc taagaaagaa tatcttcctt cgtatgagga ctatatcaat 289081 cagcaggcag agccgaagcc ctttcagcca aatggcgaac gaatccatga ctatttaaaa 289141 gaaatcacag atgaagtgtt ttctcattat gatgtcatgt ctgtcggaga ggtcggcagt 289201 gtcacaccgg aagaaggcct gaaatatacg ggaacagata agcatgagct gaatatgatt 289261 tttcactttc agcatatgga gcttgatcag cagcccggaa aagaacattg ggatttgaag 289321 ccccttgagc tttctgattt aaaatcggtt ttgacaaaat ggcaaaagaa gcttgaacat 289381 caaggctgga atacattgtt ttggtgcaac cacgaccagc cccggattgt gtccagattc 289441 ggagacgatg gggaataccg caaagcatca gcgaaaatgc tggcagccgt aatttatttt 289501 atgaagggca cgccgtatat ttatcaggga gaagaaatcg ggatgacaaa cgcgccgttc 289561 acccggattg aagactacaa agatatccaa acgatcaata tgtatcataa acgggtgttt 289621 gaaaaaggct atgatccaaa tgatgtgatg agatcgatct tagccaaaag ccgggatcac 289681 gcccggaccc cgatgcagtg gaacagcggc aaaaatgccg gatttactga cggcacgcct 289741 tggctgaagg tcaatccgaa cttcaccgca atcaatgtgg aggaagcgca gggagatcct 289801 gattctgtct taaactatta caaaaagctg atcagcctga gaaagcagta cgctgacctc 289861 atgaaaggga gctttgatct tttgcttccg gacgatccgc agttgtttgt atacatgaga 289921 gaaaacagta aacaacagct tttgtcggtc aataattttt caaaagagca ggctgttttt 289981 cagtggccta agaactgcgg caaagctcag gcctcactgc ttctcagcaa ttataacaac 290041 gatgatcttg atgacgaaat ggtgttccgg ccttatgaga gcagggtcta tcttctggac 290101 aaaacaaact aatgattgaa gtagcccggc atttttagcc gggttttttt agtacatata 290161 ttcgctctgc aggcgggaag aataaatgaa aatgaaattt attcttgcaa aacgtaatga 290221 cttcggttta ttatgatata ggattacaaa atcgttatca ttttgattta aagttactga 290281 aaaagagggg atatacgata tgtttaaaaa atggagcggt ttgtttgtga ttgcagcgtg 290341 ctttttatta gttgcagcat gcggcaactc atcaacaaaa gggtcggcgg attcaaaggg 290401 tgataaactg cacgttgtca caacgttcta cccgatgtat gaattcacaa aacaaattgt 290461 aaaagacaaa ggcgatgtgg atctgttaat cccatcttcc gttgaaccgc atgattggga 290521 accgacgccg aaagacattg ccaacattca ggatgctgat ttgttcgttt ataatagtga 290581 atacatggag acatgggttc cgtcagctga aaaaagcatg ggccaaggcc atgccgtttt 290641 cgttaatgca agcaaaggca ttgatttaat ggaaggctct gaagaagaac acgaagagca 290701 tgatcatggg gagcatgagc acagtcatgc aatggaccct cacgtatggc ttagccctgt 290761 tctggcacag aaggaagtta aaaatattac ggctcaaatc gtgaagcagg acccggataa 290821 caaagaatac tatgagaaaa atagtaaaga atatattgca aaactgcagg atcttgataa 290881 actatatcgt acaaccgcaa aaaaagcgga gaaaaaagaa tttatcacgc agcatacagc 290941 ttttggctat ctggcaaaag aatacggctt gaagcaggtt ccgattgcag ggctttcacc 291001 tgaccaagaa ccgagcgcag ccagcttggc aaagctgaaa acatatgcca aagaacataa 291061 tgtaaaagtt atttactttg aagaaattgc atcctcaaag gtcgcagata cgctcgccag 291121 tgaaatcggc gcgaagacag aagtgctgaa tacactggaa ggcttgagca aagaagaaca 291181 ggataaaggt ttagggtata tcgacattat gaaacaaaac ctcgatgccc tgaaagattc 291241 actattggtt aaatcataag atagtgtgcg ccggaggggt gcacactatt tctttgtgag 291301 aaaggaagat taacatgaat ctcgtctcat tgaaagatat cgttttcggc tattcccata 291361 cgcctgtttt agataaagta tcacttgata ttgaaagcgg tgagttcgtc ggcatcactg 291421 gaccaaacgg cgcctctaaa tcgacgctca taaaggtaat gctcggcatg ctgaaaccgt 291481 gggaaggcac agtgacgatc agtaaaagga atacagaagg gaaacgcctg accatagggt 291541 acgtcccgca gcaaatttct tcatttaatg ccggatttcc gagcacggtg ctggagcttg 291601 ttcagtcagg ccgctataca aaagggaaat ggtttaaacg tttaaatgaa gaagatcatc 291661 ttgaagtaga aaaagcattg aaaatggtgg aaatgtggga cctccgccat cgtaaaatcg 291721 gtgatttatc aggcggacag aaacagaaaa tctgtatcgc cagaatgctc gccagcaacc 291781 cggatctgct gatgctggac gaaccgacga cagctgttga ttacgacagc agaaaaggat 291841 tttacgaatt tatgcatcat ctcgtgaaaa atcacaaccg cacagttgtg atggttactc 291901 acgaacaaaa cgaagtacag caatttttag ataaagtgat tcgattagag agaggagaaa 291961 aaggcggatg gaaatgtttg acttggaatt catgcgacga gcttttctag caggcggcat 292021 gatcgccgtc atggctccga tactaggagt gtatctcgtt ctcagaagac aggccttaat 292081 ggctgacaca ctttcacata tctcattgtc aggtgttgcc atcggctttt ttctcagcac 292141 caatataacc gcagcaagca tagtcgtcgt gaccatcggc gcgatcggaa ttgaatacat 292201 gcggcgggcg tatcggactt attcagaagt gtccattgcc atcttaatgg cagctggttt 292261 gtccttcgcg atgtttttaa tcagcctttc caaaggcaca gccaatatga gcatcgatca 292321 atacctattt ggatcgcttg tgacagtaaa ccagcagcag gtctatatta tcagtattat 292381 cacactgctg atcctgcttt attttattgt actgagaagg ccgctctacc tgctgacgtt 292441 tgatgaagct acagccaaaa catcgggaat caatacaaac gttctctcgt tgtcattcag 292501 tattgtcaca ggccttgcga tttcagtcat tattccgatc atcggggtcc ttcttgtatc 292561 ggccctgctc gtattgccgg cagccttcgc catcagaatt gcaaaaggct ttaacatggt 292621 tttcattaca gccatactca tttcattatt cagcgtattt acgggactga catcatccta 292681 tcagctcggg acgccgccag gtccgtctat taccctgcta ttgatcgttt tgctattaat 292741 cggatttgca gttcagggag tttggacgtt tatcaaaaaa gaagctcagc gcaaaaaaag 292801 aagccgataa catgaaaagc agttttccct agggaaaact gcttttttta tagaaacaat 292861 tcggcaaggc gctcataaga ttcttttttc gcctcaaaat caaacacatt gcacagaacc 292921 atgatttcat ttgtttcgta gcagcctgtg aggtctaaca gctgttgttt gacagtggtg 292981 ggagaaccga tcaccatccg ctttctgttt tcttctatga gttttttatc ggacgctgta 293041 tagggatgag ctttcgcttc ctcgatgctt ggcacgcggc tgtccaagcc ttttccgacg 293101 cgaagaagcc acagatcctg gcttaatgcg agttcttctg cctcttcatc tgtttttgcg 293161 caaatgacaa aaatcgtaaa cagtgcggat ggattcgaaa aatgggctga gggccgaaag 293221 ctttcccggt agatgcggaa tgcattttct cctcgctcgg gattaatgaa atgcccaaat 293281 acatatccaa tcccctggtg cgccgcgcgt cttgcgctgt tttcaccaag accgagcacc 293341 catagctcgg gtgccgtacc aataaggggc gccgctttga ttccggcata cggatggtcg 293401 ggaggaaggg aatctgttag aaaataagag acatcctgca gctgtctgtt aaattcggtt 293461 aagctttttt tcaccccgtc cgttaatgca agtctggttt ttgtcgtgcc gccgggggag 293521 cgaccgacgc cgaggtcaat ccggtttgga tacagggcct caagctggcg aaaggtttca 293581 gccactttaa atgggctgta ttggggcaga agcacgccgc ctgatccgac acgaatggtg 293641 tttgtctgtg ctgcgatgcg ggcgatcatg atttcaggcg ctgtgcttgc cagtcctttc 293701 gtgctgtgat gctcggcaaa ccaataacgc ttatagcccc actgttcgct taattgggca 293761 agctcaaccg aatgctggag agttgtcaca gggctttctc ctttagaaac aggtgcctga 293821 tcaagtatgc ttaaatgaat caaaaggccg cttcctttct gtctgttttt agatggtgac 293881 accagaatag gcaaaatgac ttgcccgcgt caaatggttt gtttaagaag cgcactttat 293941 agcatttgca aatcatatat caaatatgga agtttttttt cgaggttttt cgtcaattat 294001 tcttaacttt tacgaaactt tgatataata acaaacgtat atattagtaa tttacggctt 294061 attttccttg tgagcgtaaa aataaatgtg actatcttca cattttgatg agtaggagtg 294121 aatcgtgtgg caatttcttt agaaaaaggt caacgaattg atttaacaaa aggaaaagcc 294181 ggtctgtcaa aattgatggt cggtctcggc tgggacccag tgtcctcagg cggaggattc 294241 ttcagcaaac tgcttggcgg aggcggtccg aatatcgact gtgacgcttc agtgctgatg 294301 ctggaaaacg gaaaattcac cgataagaaa aacctgattt atttcggcaa cctgaaaagc 294361 cgctgcggcg gtgtacagca tacaggcgac aacctgacgg gtgacggtgc gggcgatgac 294421 gagcaaatta tgatagattt agataaagtg cctggaaaca tcgataagct tgtatttgta 294481 gtgaacattt acgattgtgt cagaagaaaa caagatttcg gcatgattca aaatgcgttt 294541 atccgcgtag ttgatcaatc taatcacgag gaaatgctca agtacaattt gagagacaat 294601 tacgccggca gaacaagcct gattacagca gaaatctacc gcagcggcag tgagtggaag 294661 tttgcggcgg tcggtgaagg cacaaacgat acgagattag aagatattat cagtcgatac 294721 gtataaaaga aaaggagtgg atgaaacatg acaatttcat tggcaaaagg acaaaaagta 294781 gatttaacaa aaacaaatcc gggtctttca aaggttgttg tcggtttagg ctgggatacg 294841 aacaagtatg acggcgggca cgactttgat cttgactcaa gtgtgtttct gttagacgcc 294901 gcgggcaaat gcgcgtcacc aaacgacttt attttctaca accagcttga aggcggcaac 294961 ggttcagtcg ttcattcagg cgacaacctg actggtgctg gcgaaggcga cgatgagaat 295021 gtaaaagtaa atctcagcgc tgtaccggca aacattgata aaatctcatt tgttattacc 295081 attcacgatg cagaagcgcg cagccaaaac tttggacaag tatcaaacgc gtttgtccgc 295141 atcgtaaatg aagaaacaaa tgaagagctc atccgttacg atcttgcaga agatttctct 295201 attgaaacgg caatcattgc aggggagctt tacagacata acggcgagtg gaaattctca 295261 gcaatcggct caggctacca aggcggcctt gcccgcattg caacagacta cggtttgcaa 295321 gtcggttaag acaaatacga agagcagaaa ggagagaggc agtatggcca ttcaattatc 295381 aaaaggacag cgcattgatt taacaaaaac aaatccggga ctgactaaag cggtgatcgg 295441 cttaggctgg gatacaaaca agtactccgg cggacacgat tttgacctgg atgcttcggc 295501 ctttttagtt gatgcgcatg ataactgcgt aaatgatctc gatttcgtct tctataataa 295561 ccttgaacat ccgagcggcg gtgtcatcca tacgggtgac aaccgcacgg gtgagggcga 295621 cggagatgat gagcagatta tcgttgattt ctcaaaaatc cctgctcaca ttgagaaaat 295681 cggcatcaca gtgaccattc acgacgctga agcacgcagc caaaactttg gacaagtttc 295741 caatgcattt gtccgcgttg tggatgaaga aacgcagaat gagcttcttc gcttcgattt 295801 gggagaagac ttctccattg aaacagctgt tgtcgtttgt gagctttaca gacacggcgg 295861 cgagtggaaa ttcaatgcaa tcggcagcgg attttccggc gggctggctg cattgtgccg 295921 gaattacggt ttgcaagtgt aagcgagtga caaatagaga agtcaccgtt tcaaattata 295981 ggaggaaaaa acttggactt tttacatcat attttgtcta cgtatgcttc atttttcgat 296041 tggaaaatgt ggggggaagt tctgactgat cctgtttcct ggggtttgat cggttccctt 296101 gttgttctgg aaggcctttt atcggccgat aacgcgcttg ttcttgcggt catggttaaa 296161 cacctgccgg aaaaacagcg gaaaaaagcg ttaacgtatg gtttgtttgg agcttatatt 296221 ttcaggttta ttttcatcgg gctcggtatg cttctcatta aattctggtg gatcaaggtg 296281 cttggcgcgc tttacctggc ttggctcgtc attaagcact tctggatagg cgaaaaagaa 296341 gaggaagcgg acggcatgaa gaaaaactct tggatggtcc gcacgttcgg gatcttctgg 296401 gcgactgtca tttcagtaga attaatggat cttgccttct ctgtggacag catcctggcc 296461 gcgtttgcag tatctgaaaa agtatgggtg cttctgattg gcggtatgct tggtatttta 296521 atgatgcgta cagtggcaaa agtgttcctt gtgctgattg ataaaattcc tgagctggaa 296581 aacacagcat tcgtcttaat cggcattatc gcgctgaaaa tggcggggag cgctttccat 296641 tacgaaatgc cgcactctgt attcttcatt atcattatcg ctgcatttgc ggtaacattg 296701 atcattcact acatcaataa acaaaagcag gtgcgcgaac aaacagccgc ttcaaaagaa 296761 gaataaaaca aaacaaggag ggaggttcaa tgtccttcct tttttgttac cgaaatatcg 296821 tttcaatgac aaaccggaaa ggaggatatg atgagacaag aagaactaac cattcataaa 296881 gcacttccgg ctgatggcga ttggaaaagc ctgctgtttc agccattgcc ggagcgggat 296941 cactatgaaa ctgcacaagg cctttctttt tctcgtcttg ccggtcagat attgggcacg 297001 cctattgatg agacggacta ctataacgag ctgtatgagc tgtctgtaaa cgaccgcata 297061 acgattttga gtgaaacgct tgataaaaca atcgaaccgg aaacatttca aaagcttcag 297121 catattcatt ccatcaatca gaaagaaaaa gggctgtcag tcagccgctt tgttgccttt 297181 ctggacgggg aaaagctgat tgcgaagcac tcaaatccct tgatgcaccg ccatttaaga 297241 aaagcgttga tgacgctttt acataccttt gcggacagtc atgaaaaggg gctgaatcat 297301 cctgattttc gcagagtgct gcttgatgtc tcgaagtttt ccttaaacca tctgaaccct 297361 tggctggaaa aaaccgatat agagcgggag atgccgaagg ttgtttggta tggagatgcg 297421 acgaaaagcc agctctattt cttatattat ctgatgctgg tcggctgtga tgtactgctg 297481 ttccatccgg cgggaacgga tcagctggcg cttgtcgacc cgaagcagga gctcggtttt 297541 acggaaaagc tcccggatgt ttcggagctt cagccgtttc cgaaagaaaa accagaccgg 297601 aaatcaacag tggcttaccg ctcaacaaag gaaattgaac atgtgctgaa tcacgaggaa 297661 tccatgctat ataagccgtg gcagttcaga gatcacacac cggtgtccgt tacgctgaaa 297721 acgacctatg atgaattgtt tttaatcacg aaagaacgcg cctttattcg gccgaatttc 297781 aaagctgata aacattccat tgagattccg aatgtattcg ccaaaattat gggcgtgtcg 297841 aaagacaata aggaatattg gaacaggctt catactctag cggattatca ggaaacagaa 297901 atggtcagaa gctttccatt tacagaagaa ataaagtcga actatcaatt tcactacagc 297961 cacgcacttg atcaagaagg gaacattgat ccggacaagc tgatggcaag caatgtgtgg 298021 cagtacaaac agctgccggc gggcgttcag actgccattg ccaaaacgat ttcgagaatg 298081 tgcaggtacc cgcggcttaa agccttgcat caggaacaag tcaaggatgt tcaaatctat 298141 ttgtttaaac aaacaacaaa cctgcctgct aatctgctga aattgattca aatgttcgac 298201 tatgcgcaaa ccgttccgaa actcgtttta tatcatacgg aaatgagcgg cggactcacg 298261 cgttcggatg ctgccgccct gctgttcctg aatgaaatcg gaatcgatat catcatttat 298321 aatccgcccg gacaccaaga tattgagcag tttattgaag aggatcagta tgatatccac 298381 tggctggatg acatggtgtt tcagcaggac tacaaagagc cttcgcttgt gaaaaggctc 298441 ttcagaacca ttacccaaaa ataaggagag aagaaaagca tgacaacaga aaatcaaaat 298501 ccgcttgttc tcgataaaaa tgaagagatt tcccagcaaa aagctgacga tatccgtctt 298561 cagctccgtc aggaaccaga agtgaagcgg cttgctcaac aaattgacgt caaaaaccaa 298621 atggagctgc ttgagtacgg caaggagccg gccgttgaaa tatccaagtt ctctgaccgc 298681 atcttgggga tgatgaaaac aacaagcgtg acagactccg gcacaatgct gactcagctt 298741 gggaaaatca tggaccgctt cgacaaaaat gattttgatg agccaaaggg attaatggcg 298801 aaaattttca aacgcggcgg cagcatgatt gaaaaaatct ttaaaaagta tcagacgctt 298861 ggcggagaga ttgaaaaaat ccacgttgag atttcaaaat acaaagatga gatgacgaag 298921 acgaactaca cgctcgatga aatgtatgaa aacaatatca aatactatat ggagcttgaa 298981 aaatacgtcg ttgccgggca gatgaaactg gaagagatgc agtcgatcct tccttcatat 299041 gaggaaaaag cggcaagcgg gaaccagctg gcgcaaatgc agctcgatac gttgcgcaac 299101 ggcattcagg cgcttgagga acgggtgtat gatcttgaca tggcacggat ggtggcgctt 299161 caaaccgcac ctcaaatccg tctcctgcag cgaggaaatg caaagctgat cgggaaaatc 299221 aactccgcgt ttatcattac cattccgatt ttcaaaaacg gcattattca ggctgttacg 299281 gtaaagcggc aaaagcttgt ggctgattcc atgagcgagc ttgaccgccg gacaaacgag 299341 atgctgaaac gaaatgctga aaacatctcg agccaaagtg ttgaaattgc gagaatggcc 299401 ggcagaccga gcatagatat tgaaacgatt gaatcgtctt ggaacacgat tgtcagcggc 299461 atgcaggaaa caaaacaaat cgaagaagaa aacaagcgcc tccgcgaaga cggcgcgaga 299521 cgaattgccc agcttcagga taatattaaa aaagcagcat tgcagcaata ataaaaaccc 299581 cgcttgtgga acataagcgg ggtatttcaa ttacatcatt tagttaatga caatgtgtaa 299641 agacaggtgt aaacttaaac ggtaatcatt ttgcatatca gaggtgttgg caatgggaaa 299701 acaacagcct atatcccagc gtaaactgct gggcgtcgcc ggtttggggt ggctgtttga 299761 tgcaatggat gtcggaatat tatcgtttat tatcgccgcg ctccatgtag agtggaatct 299821 gtcgcccgaa gaaatgaaat ggatcggaag cgtcaattcc atcggcatgg ctgcgggtgc 299881 gtttttgttt ggtttgcttg ctgatcgaat cggccgcaaa aaagtgttca tcatcaccct 299941 tttatgcttt tccatcggaa gcggcatttc cgcttttgtg acgagcttat cggcatttct 300001 aatccttcgt ttcgtgattg gtatgggact tggcggcgag cttccagtcg cttcaacact 300061 cgtttcggaa gcggttgtgc ctgaaaagcg gggcagagtg attgtgcttt tggaaagctt 300121 ttgggccgtg ggctggctcg cagcggcctt gatttcttac tttgtgatac caagcttcgg 300181 ctggcaggct gcccttctgt taactgcgct gactgctttt tatgcgctgt acctgcggac 300241 gagtctacct gattcgccga aatatgaatc gctttctgcc aaaaagaggt cgatgtggga 300301 gaatgtaaaa agcgtctggg caagacagta tatacggccg acggtgatgc tgtcgatcgt 300361 ttggttctgt gtggtgtttt cttattacgg catgttccta tggctcccga gtgtcatgct 300421 gctgaaaggc ttcagcatga ttcaaagctt tgaatatgtc ctgctgatga cgcttgctca 300481 gctacctggc tatttctctg ccgcatggct gattgaaaaa gcgggccgga agtggatact 300541 cgtcgtttac ttgattggca cagcaggaag cgcctatttc ttcggaacgg cggattcctt 300601 aagtcttctg cttacggctg gagtgctgtt atcgtttttc aatctcggtg cgtggggcgt 300661 gctgtatgct tataccccgg agcaataccc gactgcgatt cgagcaacag gttcaggaac 300721 gacagcagcg tttggaagaa tcggcggcat cttcgggcct ttgctcgtcg gaaccctggc 300781 agcccgtcat atttcgtttt cggtcatctt ttcaatcttt tgcattgcaa tcttacttgc 300841 ggttgcttgt attttgatta tggggaaaga aacgaaacaa actgagctag aataggaaaa 300901 gcacctctta aaagaggtgc tttcagcgtg tcgacaaacc ctcgcattcg ttgtcaggac 300961 tgcgcttcgg tgctcaatgc gaagtggatc aacggctaaa ttctcaggcg tcctgcctaa 301021 acgccgtcgt catcacatcc tgtgaatgtc cgctcctatg ctcgtccttc ctagacttca 301081 agggttttca atcacgctga aaagattttg tcaacaatct gaggcacctc ttgaatgagg 301141 tgctttttta caattgcgcc cgggctgtgg attggcgttt cccggtttta ctgattgtct 301201 ggtagagcgt catagaaagt atgaacagaa tggcagtaaa tcctgtgaca gctccgaaat 301261 gctgtgtgct ttgatataaa aaacctgcaa tacttgtacc gacagtggtt ccggcataca 301321 tagcggcatt ggaaagggaa gcgatggttc ctcgcgcatt tggtgcaatg gattgaaaga 301381 cacccatcat taacggaaag atgatgccag ctgtaaagaa cgtgagaaaa aagccggctt 301441 ctactaaaaa caagtttgga aagaacggaa gagcgaaata gagagcgccc attagcagca 301501 tcccgctgat cagtgtttta aacatgccca gcttttctga aacccggctg ccgataaggc 301561 tcccgagcat atttcccagt ccgagtacaa gcatagctgc gccaatttgt gacacggtta 301621 aatgataatc cgcggaaagc caagtaccca gaaagctgaa cgatgcgaag tttccggttt 301681 gaaacagaaa ataggcaagc agaatgaccg atgttttcgg caatgaaaaa agctcccgat 301741 aggggttgac aattgatggg cgcgccaatg gttcagaagg ccggatgcca ggcatgaccg 301801 ccgccaggat caatagaaga ataagcgagc acgctgacaa aacgaaaaat ggcgtatgcc 301861 atgtaaagga agcgagaaac cctccaatag gaagtccgag catttgtgaa gcggccaaac 301921 ctgctgtcgc aatccccatg ccttttatga tctgagaagg ctggacaatg actgggatgg 301981 acgcccaaat ttgaggcgtc acaaacgcag cgctaacgcc tgcggcaaaa cggaacaggc 302041 acatggcggc aaaagaggga gcgatgccgc ataaaaatgt ggatacgata aagcctgcaa 302101 gtccccacag catgactgtt ttcctgttca gccggtctga gattgggcct gcaatgaaag 302161 cgaagagtgc ataaccgagt gcataagcac tgaccatcca gcctgacaaa tcagtagaga 302221 catgaaactg atcctgtaaa agggggagaa gcggcgaaag caaaaaggta tccgtgccaa 302281 tgacaaacat gacactgaag aaaagccaaa tgcgattcaa attttatcac tcctattgtt 302341 ttataacttt aaaactatga aacagatatg tatagagaaa accctttgtt agagggtttc 302401 caaaaagcca ggcaggtatg tttgaaatgt gtcttcacgc agactgacgt attttgtccg 302461 cgaatctttc cgggttgccg tcaatcccgc ttcacgcagc gttttaaaat gataagatgc 302521 cgtggttttg acaatattgc acttttcacc tacttcaccg cagctgagtt cttttccgct 302581 gacataaagc gtacgaataa tggcaagcct tgattcatca gacagtgctt taaaaatttg 302641 cgctctgatt tgatcatctg attgtttcat agtcatgaaa ctataataca taatgggtgt 302701 tgaaaaagca acttattttt ccagtaaagg agcaggaagt cataagagga aggaggaatt 302761 caattccaat aaaagcgttt tcaactaaag gtaggagaaa aatcacccgt aaaatacaat 302821 catataggag gattacagag catttagaag cataaataag atcatgtggt cacatggatg 302881 tttataaaga aatggtacag aataaaagag aatatgctgt ttgtgtggga agttacataa 302941 atgttacggt aataaagatt gcttaatatg gagggaaaat atgagtgtag atgagaaacc 303001 aattaagata aaagtcgaga aagtctctaa gatttttggg aaacaaacaa agaaggcagt 303061 tcaaatgctt gccaacggaa agacaaaaaa agagatcctg aaagcaaccg gatcaaccgt 303121 tggggttaat caggcagatt ttgaagtata tgatggtgag atatttgtca tcatgggtct 303181 atcagggagc ggtaaatcaa ctttagtacg gatgttaaac cggcttattg aaccgactgc 303241 cggaaatatt tacattgatg gtgacatgat aacaaatatg tcaaaagacc agctccggga 303301 agtccgccgg aaaaaaatca gcatggtctt ccaaaagttc gctctgtttc cgcacagaac 303361 gatacttgaa aacacagaat acggactgga gcttcaaggt gtagacaaac aagagcggca 303421 gcaaaaagcg cttgagtctc ttaagctcgt tggactggaa ggatttgaac accaatatcc 303481 cgaccagctt tccggcggga tgcagcagcg tgtcggcctt gcccgcgcgt tgacgaatga 303541 cccggacatc cttctgatgg acgaagcgtt cagtgcgctc gatccactga ttcgtaaaga 303601 tatgcaggat gagcttcttg atcttcacga taatgtcgga aaaacaatta tctttattac 303661 gcatgacttg gacgaagcgt tgcggatcgg cgacagaatt gtcctaatga aggacggcaa 303721 catcgttcaa atcggcacgc ctgaagaaat cctgatgaat ccatctaacg aatatgttga 303781 gaaattcgtc gaagatgttg atttgtctaa agtcctcaca gcaggccaca ttatgaaacg 303841 cgctgaaaca gtgcggattg ataaagggcc tcgcgtagca ttgacactga tgaaaaacct 303901 tggaatttct tcaatttatg cagtggataa acaaaagaaa ttattaggtg ttatctatgc 303961 gtctgatgcg aaaaaagcgg ctgagtctga tttgtcactt caagacatct tgaatacaga 304021 atttacgact gtaccagaga atacgtatct gactgagatt tttgacgttg tgtccgatgc 304081 gaatattcca attgcggttg tggatgagaa gcaaagaatg aaaggaattg tcgtaagagg 304141 cgcgctgatt ggcgcacttg ccggcaataa cgagtatatc aatgctgaag gcactaacga 304201 acaaacacaa gatccttctg cacaggaggt gaaataagat ggatagactg cctagaatac 304261 ctttagcaga tattattgac cgttttgttg actggattac gatgacgttt ggcggattct 304321 tcgacggaat cgctaacgga ttggccgctt ttgtaaatgg aattgtcacc ggtcttggat 304381 ttattccatc tattttgtta acgattattt tcgccgcact tgcgtggtgg atcagtacaa 304441 ggggaattgc gttatttacg ttgattggat tcctcctgat cgattattta ggatattggg 304501 acccaatgct gcaaacattg gcgcttgttt tgacatctgt gattatttcg attgtggtcg 304561 gggttccgat cggaatttgg gcgtctcaga aagaaacggt tcgccgtatt gtaacgccaa 304621 ttcttgattt aatgcagaca atgcctgctt tcgtatatct attgccggcg attttcttct 304681 ttaacatcgg tgttgtgccg ggtgttgttg catctgttat cttcgcgatg ccgccgacaa 304741 tccgcatgac tgttctcggt attaaacaag tgccggcgga tttgattgaa gcgactgagg 304801 cattcggttc tacaacagct cagcgtttgt ttaaagttca gctcccgctt gcgacaaaaa 304861 cgattttggc cgggatcaac cagagcatca tgcttgcgtt atcaatggtt gttatcgccg 304921 caatggtcgg tgcaccggga cttggttctg aagtatacag tgccgttaca cagctgaaaa 304981 ccggggtcgg agtagaggcc ggtatcgcca tcgttatcgt tgccattacc ctggaccgta 305041 ttactcaaaa tattaaagtg aagaagaaaa gcagggggaa tgcctgatgc ttaaaaaaat 305101 cataggcatc ggcgtttccg ccatgctggc gctctcactt gcggcttgcg gttcagaaaa 305161 cgatgaaaat gcatccgcag cagaacaagt gaataagacc atcatcggga ttgaccccgg 305221 ttcagggatt atgtccctga ctgacaaagc gatgaaggat tatgacctga atgactggac 305281 attgatttca gcgtcaagtg ctgcgatgac cgctacgctt aaaaagtcat acgaccgtaa 305341 gaaaccgatt atcattacag gatggacacc gcactggatg ttctccagat ataagctgaa 305401 atatctcgat gatccgaaac aatcttatgg cagcgcagag gaaatccata cgatcacacg 305461 caaaggcttc agcaaagagc agccgaatgc cgcaaagctt ctgagccagt ttaaatggac 305521 gcaggacgaa atgggcgaaa tcatgatcaa ggtggaagaa ggcgagaaac ctgccaaagt 305581 tgctgctgag tacgtcaata aacacaagga tcagattgcc gaatggacaa aaggcgttca 305641 aaaggtgaag ggagacaaaa tcaaccttgc ctatgtggcg tgggacagtg agattgcaag 305701 tacaaacgtc ataggcaaag tcttagaaga cttgggctat gaggtaacac ttactcaggt 305761 agaggctggg ccgatgtgga ctgcaattgc gacgggaagt gcggatgcat ccctttccgc 305821 atggctgccg aatacccata aagcatacgc cgctaaatat aaaggcaaat atgatgatat 305881 tggcaccagt atgactggtg tgaagatggg gcttgttgtt cctcaatata tgaaaaatgt 305941 caactcaatt gaagatttga agaagtaatc aaaaaagcag cctgtgtcag gctgcttttt 306001 ttgcgttaag aagcgttagc ggcagcaagt gattccgcct tctgaaatgt tttgagcacg 306061 gcgttcgcca aaatatgaat gccggtaaac atcgcatttc tgtcaaaggt catgtgcgga 306121 tgatggagcc ccggctggag cccgcagcct agtccgagca tcgttgtttt cagattcggc 306181 accttcacgg cgtaaaaatg gaaatcctcg ccgccggtgg tgacaagcgg gtcatcaagc 306241 cgctcagccc cgatgatttc cgtaatggct tctgccatga tcgcttcagc ttctttattt 306301 tgtgttgccg caggaaggct gtgttctttg tgcagctcga tctttgcgcc aaatgcagcg 306361 gcggccgctt cacaggctct ttctgtttcg gcgattaatg cctccatggc ttcattggtc 306421 tgtgcgcgca aatcaaggct gaacgatgct tttcctggaa tgatgttaga gctttcaccg 306481 ccggcttgca gttttgtcat tttgacggta tgcgggattt gcgggtcaat atgaatgagt 306541 ccgagcttgt gtacaagaaa tgccgcaatt tcaatgctgt ttttcccgag gtgcggacgg 306601 gcgccatgag cctcttcccc gatgatcgtt ccctcaatgt gctggcttga tccgtgcaga 306661 atagaaggag cgcagcggcc gttctgtgtt tcctggatcg gacggacgtg aacgccatac 306721 aaatagtcga tatcatcaag cacgccttct tctatcattt tcaaggcgcc gccgcctttt 306781 tcttctgccg gctgaaagat aaaacggatt gtgcccttcg gaagctcagg ttgttttttt 306841 agcagcatta acgtgcccaa tgccattgtc atatgtgaat cgtgtccgca ggaatggttg 306901 gcgcgaaatg tgccgttaac ctcctgccac agcgcgtcaa tatcagcgcg taccgctaca 306961 acaggtgagc ctgagccgat ttcgccgaca accccggtgc agtctgaaaa cgtgcgcgtc 307021 cggcacccta aatcctcaag cttttgtttc aaaaatgaag ttgtctcata ttccttccag 307081 ctgacttcag ggttcgcgtg cagatgctcg aagatgtcca taatggtttg tttcatttct 307141 tctgaaagct tttgcatggt aagaaatacc tccttctatc agaatgaatt tttaccttct 307201 ttactttatt tatattgaaa caggaagata ggctgtatat aatatagcac atattgctac 307261 tattcagaat aattaatatt ttcaaacaga ggggatggat cgaaatatga gtatgccagc 307321 agccgaaaca cagcctaaga aaaaacgtat gacatttaaa atgcctgacg cctatgtcct 307381 cttatttatg attgctttca tttgcgcaat cgcttcatat attgtgccgg caggtgaatt 307441 tgaccgcgtg acaaaggggg atgtcacgac cgctgttccg ggaagctatc attcaattga 307501 acagtctccg gtcagattga tcagcttttt tacttctcta caggatggaa tggttggatc 307561 agcacccatc atctttctga ttttattcac aggcggcacc attgctattc tagaaaaaac 307621 gggtgccatc aatggcctga tttacaatgt catcagcaaa ttccgcacaa agcaattatt 307681 atttatttgt attgtcggcg cattgttctc cattctcgga acaaccggga ttgtcgtgaa 307741 ttcagttatc ggttttatcc ccatcggcct cattgtggca cgatccttaa aatgggacgc 307801 agtcgcggga gccgctgtta tatacatcgg ctgctacgct ggatttaact ccaccatatt 307861 atcaccgtca ccgctcggtt tatcacaatc aatcgcggag ctccctcttt tctcaggaat 307921 cggcctgcga gttgtgatat acatatgctt tttgctgtct tctattattt atatctattt 307981 gtatacgaga aaattaaaaa aatcaaaaga tgccagtgtg ttaggaacag attggttccc 308041 tgcggcagga atgggcgaag ccggtaaaga agaagatcag tcagtgccgt ttaccgttcg 308101 ccataagctg attttggctg tggcgggact ctcacttgtc ggatttttat acggcgcttt 308161 gaagcttggc tggtcagatt cccaaatggc tgcgacattt atttttattt ctgtccttgc 308221 cggtttaata ggcgggcttg cggcgaacga tattgccaaa accttcatta cgggctgcca 308281 aagtcttgta tacggggcgc tgattgtcgg gatggcacga agcatttccg ttatccttga 308341 aaatggaaag cttctcgata ctgtcgtcaa tgctttggct tcacttttgg atggattcag 308401 cccgattgct ggggcaatcg gcatgtatat cgccagtgcg ctgcttcatt ttctcatctc 308461 ttcaggttct ggcgaagccg ttgtatttat tccaatcctg gcgccgctcg ctgatttgat 308521 gggaatcacg agacaggttg cggttgaagc ggttatgctt ggagaagggg tcgtcaactg 308581 tgtgaacccg acatccggcg ttctcatggc ggtgcttgcc gccagcggta ttccgtatgt 308641 caagtggctg cggtttatgg tgccgcttgc tctgatttgg ttcttgatcg ggcttgtctt 308701 tatcgtgatc ggagtcatga tcaattgggg gccgttttaa cgattgctgc ccgccggctt 308761 gtacggcggg cttttgagtt attcattgca gaagcgcagg ctgttattgt aacatgtaag 308821 ccataagcca ttcgtaaaag tgcgggagga aggtcatgaa taatctgcgt aatagacttt 308881 caggcgtgaa tgggaaaaat aagagagtaa aagaaaaaga acaaaaaatc tggtcggaga 308941 ttgggatgat agcgggagca tttgcgctgc ttgatgtgat catccgcggc attatgtttg 309001 aatttccgtt taaagaatgg gctgcaagcc ttgtgttttt gttcatcatt atcttatatt 309061 actgcatcag ggctgcggca tccggaatgc tcatgccgag aatagacacc aaagaagaac 309121 tgcaaaaacg ggtgaagcag cagcgaatag aatcaattgc ggtcgccttt gcggtagtgg 309181 tgcttacgat gtacgacagg gggattcccc atacattctt cgcttggctg aaaatgattc 309241 ttctttttat cgtctgcggc ggcgttctgt ttctgcttcg gtatgtgatt gtgaagctgg 309301 cttacagaag agcggtaaaa gaagaaataa aaaagaaatc atcttttttg tttggaaagc 309361 gagggaagcg ttcacagttt cgggcagctt tttttatagg aacattgatt tgtattcact 309421 ctgccaagtt gttttgatag agtgattgtg ataattttaa atgtaagcgt taacaaaatt 309481 ctccagtctt cacatcggtt tgaaaggagg aagcggaaga atgaagtaag agggattttt 309541 gactccgaag taagtcttca aaaaatcaaa taaggagtgt caagaatgtt tgcaaaacga 309601 ttcaaaacct ctttactgcc gttattcgct ggatttttat tgctgtttca tttggttctg 309661 gcaggaccgg cggctgcgag tgctgaaacg gcgaacaaat cgaatgagct tacagcaccg 309721 tcgatcaaaa gcggaaccat tcttcatgca tggaattggt cgttcaatac gttaaaacac 309781 aatatgaagg atattcatga tgcaggatat acagccattc agacatctcc gattaaccaa 309841 gtaaaggaag ggaatcaagg agataaaagc atgtcgaact ggtactggct gtatcagccg 309901 acatcgtatc aaattggcaa ccgttactta ggtactgaac aagaatttaa agaaatgtgt 309961 gcagccgctg aagaatatgg cataaaggtc attgttgacg cggtcatcaa tcataccacc 310021 agtgattatg ccgcgatttc caatgaggtt aagagtattc caaactggac acatggaaac 310081 acacaaatta aaaactggtc tgatcgatgg gatgtcacgc agaattcatt gctcgggctg 310141 tatgactgga atacacaaaa tacacaagta cagtcctatc tgaaacggtt cttagacagg 310201 gcattgaatg acggggcaga cggttttcga tttgatgccg ccaaacatat agagcttcca 310261 gatgatggca gttacggcag tcaattttgg ccgaatatca caaatacatc tgcagagttc 310321 caatacggag aaatcctgca ggatagtgcc tccagagatg ctgcatatgc gaattatatg 310381 gatgtgacag cgtctaacta tgggcattcc ataaggtccg ctttaaagaa tcgtaatctg 310441 ggcgtgtcga atatctccca ctatgcatct gatgtgtctg cggacaagct agtgacatgg 310501 gtagagtcgc atgatacgta tgccaatgat gatgaagagt cgacatggat gagcgatgat 310561 gatatccgtt taggctgggc ggtgatagct tctcgttcag gcagtacgcc tcttttcttt 310621 tccagacctg agggaggcgg aaatggtgtg aggttcccgg ggaaaagcca aataggcgat 310681 cgcgggagtg ctttatttga agatcaggct atcactgcgg tcaatagatt tcacaatgtg 310741 atggctggac agcctgagga actctcgaac ccgaatggaa acaaccagat atttatgaat 310801 cagcgcggct cacatggcgt tgtgctggca aatgcaggtt catcctctgt ctctatcaat 310861 acggcaacaa aattgcctga tggcaggtat gacaataaag ctggagcggg ttcatttcaa 310921 gtgaacgatg gtaaactgac aggcacgatc aatgccaggt ctgtagctgt gctttatcct 310981 gatgatattg caaaagcgcc tcatgttttc cttgagaatt acaaaacagg tgtaacacat 311041 tctttcaatg atcaactgac gattaccttg cgtgcagatg cgaatacaac aaaagccgtt 311101 tatcaaatca ataatggacc agagacggcg tttaaggatg gagatcaatt cacaatcgga 311161 aaaggagatc catttggcaa aacatacacc atcatgttaa aaggaacgaa cagtgatggt 311221 gtaacgagga ccgagaaata cagttttgtt aaaagagatc cagcgtcggc caaaaccatc 311281 ggctatcaaa atccgaatca ttggagccag gtaaatgctt atatctataa acatgatggg 311341 agccgagtaa ttgaattgac cggatcttgg cctggaaaac caatgactaa aaatgcagac 311401 ggaatttaca cgctgacgct gcctgcggac acggatacaa ccaacgcaaa agtgattttt 311461 aataatggca gcgcccaagt gcccggtcag aatcagcctg gctttgatta cgtgctaaat 311521 ggtttatata atgactcggg cttaagcggt tctcttcccc attgagggca aggctagacg 311581 ggacttaccg aaagaaacca tcaatgatgg tttctttttt gttcataaat cagacaaaac 311641 ttttctcttg caaaagtttg tgaagtgttg cacaatataa atgtgaaata cttcacaaac 311701 aaaaagacat caaagagaaa cataccctgg aaggatgatt aatgatgaac aaacatgtaa 311761 ataaagtagc tttaatcgga gcgggttttg ttggaagcag ttatgcattt gcgttaatta 311821 accaaggaat cacagatgag cttgtggtca ttgatgtaaa taaagaaaaa gcaatgggcg 311881 atgtgatgga tttaaaccac ggaaaggcgt ttgcgccaca accggtcaaa acatcttacg 311941 gaacatatga agactgcaag gatgctgata ttgtctgcat ttgcgccgga gcaaaccaaa 312001 aacctggtga gacacgcctt gaattagtag aaaagaactt gaagattttc aaaggcatcg 312061 ttagtgaagt catggcgagc ggatttgacg gcattttctt agtcgcgaca aatccggttg 312121 atatcctgac ttacgcaaca tggaaattca gcggcctgcc aaaagagcgg gtgattggaa 312181 gcggcacaac acttgattct gcgagattcc gtttcatgct gagcgaatac tttggcgcag 312241 cgcctcaaaa cgtacacgcg catattatcg gagagcacgg cgacacagag cttcctgttt 312301 ggagccacgc gaatgtcggc ggtgtgccgg tcagtgaact cgttgagaaa aacgatgcgt 312361 acaaacaaga ggagctggac caaattgtag atgatgtgaa aaacgcagct taccatatca 312421 ttgagaaaaa aggcgcgact tattatgggg ttgcgatgag tcttgctcgc attacaaaag 312481 ccattcttca taatgaaaac agcatattaa ctgtcagcac atatttggac gggcaatacg 312541 gtgcagatga cgtgtacatc ggtgtgccgg ctgtcgtgaa tcgcggaggg atcgcaggta 312601 tcactgagct gaacttaaat gagaaagaaa aagaacagtt ccttcacagc gccggcgtcc 312661 ttaaaaacat tttaaaacct cattttgcag aacaaaaagt caactaaccg caactttaga 312721 gtaaagggct gattgtcaat gtgggagcag ttgtatgatc cgtttggaaa cgagtatgtg 312781 agcgcacttg tggcgctcac tccgattctc ttttttcttt tggctttaac tgttttgaaa 312841 atgaaaggca ttcttgcggc atttcttacc ctagccgtca gtttcttcgt ctccgtttgg 312901 gcatttcata tgccggttga aaaagcgatt tcttctgttt tgttaggaat cgggagcggg 312961 ctgtggccca ttggctacat cgtcctgatg gcggtgtggc tgtataaaat cgccgtgaaa 313021 accgggaaat ttaccattat tcggtccagc attgccggca tttcgcctga ccaacgatta 313081 cagctattat taattggttt ttgttttaac gcgtttttag aaggcgcggc cggttttggt 313141 gttccgattg cgattagtgc ggcgctgctc gtcgaacttg gttttaaacc gttaaaagcg 313201 gcggcgctct gcttgattgc aaacgctgcc tccggagcct ttggggcgat tgggattcct 313261 gtcatcacag gggcgcagat tggtgatttg tctgctcttg agctgtctcg gacattaatg 313321 tggacactgc cgatgatctc atttttaata ccattcctgc ttgtattctt attagaccga 313381 atgaaaggaa tcaaacagac atggcccgct cttctggttg tgagcggtgg gtatacagcg 313441 gttcagacac tgacaatggc ggtgctcggg ccggaattag caaacatttt ggcggcctta 313501 ttcagcatgg gcgggcttgc cctcttcctc cgcaaatggc agccgaaaga gatttaccgc 313561 gaggaagggg ccggcgatgc tggtgagaaa aaggcatacc gtgccgctga cattgcgaaa 313621 gcgtggtctc ctttctacat tttaactgcg gcgatcacca tctggagcct tcctgccttc 313681 aaagcgcttt tccaagaagg cgggctgtta tatcaatcaa cgctcctgtt caaaatgcct 313741 tttctgcatc agcaaattat gaaaatgccg ccgattgcgc catctgccat gccgttagat 313801 gcagtcttta aagttgatct gctgtcagcg actggtacag cgattttagc ggcggtcatc 313861 gtgacagggc tgttcagcaa aaagttctcc tctcgggatg cctttgcttc cttgaaggag 313921 acgggaaaag agctgtgggt gccgattatg acgatctgct tcgtgatggg gtttgccaat 313981 ctggccaact tcgcagggct cagctcttca attgggttag cattggcgaa aacaggagac 314041 ctgttcccgt ttgtcagtcc tgttctcggc tggattggcg tgttcatcac cggttctgtt 314101 gtcagcaata atgctttgtt cggccatttg caggttgtca cgggagcgca gatcggtgcg 314161 ggttcagatt tgctgttagc cgcaaatacg gcgggcggtg tcatggcgaa acttgtttct 314221 cctcaatcta tcgccatcgc tgccgcagcg gtcggccaaa caggcaagga atctaaactg 314281 tttaaaagga cagtggcgta cagcctgatt ctgttattga tcatttgtat atggacgttt 314341 attcttgcaa gattaggagt gtaatagaaa aaagcagtac atgcccagca tgtactgctt 314401 tttttatgtt aatttgcttt ctttgtcatt tcggctgttg ttttcactct ggcttttccc 314461 ataaataaaa tggtaaccgc cgcgaggaca attggaatca aagcgagcaa aaagacatac 314521 gtgatacttg atgacatcgc gtcaataatg cgattcagga tcgcatcagg aatctgggaa 314581 cgtgttcccg cttggaatat ctcctgcggg tcgccaatat tttgcgcagc gcctgatccc 314641 gctgagcctt tcataccgct gaaggcgtca ttcagcttgt ttgtgaatac gtttgtttgc 314701 accgttccga aaatggtgac acctaaggtc atgccaaatg atcgcaaaaa tgaatttgta 314761 gagtttgccg ttccccgaaa gcgaggttca agatcattca tcgatgccgc cggcagcagg 314821 gagaagttaa agcctacacc aaagcctgaa atcatcataa agactgtcag ccatacccgt 314881 gctgtgtcag gcgtcatatt ggaaagaagc agcatgccga taaagaaagc tataacagat 314941 atcagcatca aattgcggaa gcttgccttc gtttggaaga tcccgccgat catgcttccg 315001 atgactgatc caatcatcat cggcgtcaga atgaagcccg cgcttgtcgc cgagctgccg 315061 tagaccgcct gaacgaaaat cggaataaat accgctaaaa taataaatgt tccgccatac 315121 aggaaagcga gaatctgtgc tgtggcaaac aagcggttct taaacatcca gaaagaaata 315181 atcggctctt ctgcttttct ctccacaata aaaaaggcaa tgaagaaaac ggcgaataca 315241 ataaacagcc cgatgatctg aatggagttc caatcgtatg ttttgccgcc aagctcaagg 315301 gcgaacatca ggcatacaat ggatacgact aaggtaatcg cgccgcccca gtctattttc 315361 tgctttctgt gctccagaga ttctttgtag tagcgaataa tgaaaaacaa tgacaatgcg 315421 ccgatcggca cattgatgta aaacacccag tgccagctga tcgaatctgt aatgatcgcg 315481 cctaagagcg gaccaagaac actggataat ccaaatacag caccgaacat gccggacatt 315541 tttccgcgtt tttccggcgg aaacaaatca aagataatgg taaaggcaat cggcaggagc 315601 gcgccgcctc cgatcccttg aatggcccgg aagatgatca gctgattcat cgtctgggca 315661 atcccgcata aagcagaacc gattaagaaa aaaataagtc caaacaggaa aaaacgtttt 315721 cggccgtaca tatcggaaag cttgccgtaa atcggcatgc cagccataac cgccaccata 315781 taggatgccg tcacccaggc aaatttatcg aagcttccaa gatcggctac gatattgccc 315841 atcgcggtgg caacaatcgt attgtccatt gcagacatca agatgcccag caggagaccg 315901 aggaccacaa atttggtgga agcctgtttt gctgttgttg tgtccatttg ttctacctcc 315961 tcttactttt ctatgtaagt tctgatatca tgataatagt ttgattgttg aatatctcga 316021 ttatcaagat aaactcgatt ttatagggag gactgtcagt tgtcaacaag aaattccaga 316081 agtgagttgg aaaagactgc tgttcagctt tttcgaaaac tgggcacaag aacggttctg 316141 tttcatcagg cagccgctca agctctcggt ctgtttccca ccgatttgaa atcagctgac 316201 attttaaatg aagcagggcc gatgacggcc ggagagctgg ggaaaaaaac cggcctcagc 316261 acgggttccg tcacggcgct tgttgaccgg ctggaaaaag cggggtatgt ggctcgtgaa 316321 aaggacccga acgatcgcag gagagtcgta atcgtccctt tgactgcttc gaaaaaacat 316381 ataaaggatt tgttccgtcc tctgtctgag tcaacgatgg atttgtgccg cgaatatacg 316441 gaagaggagc tggaactcat tttcagtttt gtaggcaaag ctgccgatat tatggaggaa 316501 gagcttgaac gtctgaaaca gtaagtgaat ttgtgcatag cttggcccgt tcccgaataa 316561 attgtacaag ttacataaga gaagggagta cgggccggtg aacatttttt tgagctatat 316621 tgtgctggga ctgtccttgt ctgcgcctgt ggggccagtg aatgcggcgc aaatagacaa 316681 aggaattaaa aacggttttt ggcatgcatg gattttcggt ttaggcgcca tgacagcgga 316741 tgggctgtac atgcttttta tctatttcgg gctgtcgcag ttcttgaccg ctccatttgt 316801 gaaaacgttt ttgtggctgt tcggcttttt tgtcctgacc tataccggaa ttgaaacgct 316861 gaaaaacgtc agagaaccga tggatgtgcg aagctcgcgg gggaaaccgt catacaggaa 316921 aacattcgca tcgggttttc tcatttcatt gtcaaaccca ttgagcatcc ttttttggct 316981 tggaatttac ggaagcattc ttgcgaaaac agcagaggcc tacaatatga atcagcttct 317041 aatctatagc tccggcatca tgatcggcat tttaatctgg gatttctgca tggctatcac 317101 agccagtacg ttcagaaacc tgcttcatga aaagctattg agaggattga ccggaatcgc 317161 cggtgtatcc ctccttgtgt ttggctttta ctttggttat cagggcatca aacagttatt 317221 gggctgattc atgaaggaca gtcacctgcc gcttccagtt ttaatatagt atccagatga 317281 tactggaggt ggatcaatgg tgaatgggat ttacaccaaa agttttctgg aacgtattca 317341 ggaagagctt cctgaatggc aaagaatcgc ttttgagctg ctggcagaaa ctctggggga 317401 cgacgcggat acatttccgt gcattcccgg acgccaggcg tttctgactg atcagcttcg 317461 gattgctttt gccggagatc cgcgggaaaa ccgcacagcg gaggaactgg ctccgttgct 317521 tgcggagtac ggcaagatat cgcgggacac gggaaaatac gcatccctcg ttgtgttgtt 317581 tgatacaccg gaagatttgg cggagcatta ttcgattgaa gcgtatgaag agctgttttg 317641 gcgcttttta aatagactga gtcatcaaga cgaaaaagaa tggccggaag acattccggc 317701 cgatcctgag cattataaat gggagttttg ttttgacggc gagccgtatt tcattctgtg 317761 cgctacaccg gggcacgagg caagaagaag ccggagcttt ccttttttta tggtcacgtt 317821 tcagccaagg tgggtgtttg atgacctaaa tggatcaact gcatttggcc gtaacatgag 317881 caggctgatc cgatctcgtt tagaggccta tgatcaggct ccgattcacc cgcaattagg 317941 ctggtacgga ggaaaagata atcgtgaatg gaagcagtat ttcctccgtg atgacgaaaa 318001 acaggtatcg aagtgcccgt tttcttattt aaagaacatg ttcaacaaaa tgaaataaat 318061 caaggactgg cagggcgatc tttatgaccc tgcttttttt gatagatcat ggtaacgatg 318121 gcgataatca cgagaaaacc tatgctgacg aaaaaaccgg gccggcttga tttttcaaac 318181 aatgtaccgg acacagctgc agcaatcaga accatcgcta aataaatttg cgtttttccc 318241 atgccctcgg gatcagtcag ctttttgctg gagaacagga taaacagcca agtgtataaa 318301 agcataagcc ccgcagctgt tgtcatatgc tcataaatgt ttttaggcag cactaacgac 318361 aaaataatgg agaggacaag ccccgcaaac gtcagcccaa gtgccggcca gcatattttt 318421 ttgccttcct ttagagtaaa gcatttcggc gcgtcgccgt catcagccat tgtacaaagc 318481 aatgtcgtaa ccgcaaatag cgaagcgaca agggtcgaga accctgcgat gatgaaaatc 318541 ccgttaaata tatcaaggat gatctcaagg ttatatcctt ttaatgacgt aatgaacgga 318601 ctgtcctgtt cagtaaacgt gtgtaacgga accaaaagca gagcaagccc gattgaaatg 318661 atataaataa tcgccagcgt cgccagcatc agtttccctg atttagacgc ttcctcaggt 318721 ttttttaagt gaaccgccat cagccccatg acctcaattc cgccaaaagc gtaaaacgcg 318781 tagattaaac ctgtccacag ccccatggcg ccgtatggga aaaactcact cgtcttattt 318841 ggaacatgta tgccatgatt tccgccggac aggataccgc ataaagccag gatggcaatg 318901 acaataaaca taaaaatagc agctgtttta atgactgcca gcacgttttc tgttttttca 318961 aagacggaca ggccggtgaa aataataagg agcccaagta ctgcgtagat tgaggcaaac 319021 acccatagcg gcacttgagg aaaccaatgc ttcgtaaaga gcgaaatggc tgtcagctgg 319081 cttccggtaa tcagcatttc tgatgtccag tacacccagc cgttgctgaa gcctgcccat 319141 ttgccgaatg cttttcgggc atacgcacaa aacgagccct tttccggctg cttcgccgat 319201 agcttggcga gctgttcaaa gacaaaatac gtaccgatcc ctgcgatcag aaatgaaagg 319261 agaacggaaa aaccgctttt tacaattgcg atgctggaac cgagaaagaa gcctgttcca 319321 atcgtgcagc cgactccgat cagtgacagc tgccaccaag ccagattccc ttttggctgg 319381 tctttttttg tttggctcat tatttattca acccctttta tctaaggtta gattgtgatc 319441 tgtccaaagc ttatatacat cggatttttg cctcttttta catggagaag gaagcagacg 319501 ctcatactaa tgaaaaaagg agcaaaccaa tgacacagca atatattgtg gagccgaaaa 319561 aagggcttgg gctgaagctg aaaaaggggc agattttaaa ggtggttgat gtagaagggc 319621 agcaggtggc tgattttgtc gcataccatg ccaaggattt ttatgaacac cttgatcagg 319681 gagcgacgat agacgccaat cactccattc atgtgaaggt caacgaccat ctctactcca 319741 acctgtataa gccgatgtta accctgattg aagatacggt cggcaagcat gatctgctgt 319801 tgcccgcctg ccgtcctgat atgaacaggc tcttatatgg gaagcaaaag gatgagtttc 319861 aggatacgtg ctatgacaat atgaaccgtg cgcttgagca gtttggcgta ccgaagcccc 319921 acatgcatta cccatttgcg atttttatga atactgtcct tgatgagaaa gggaatctgt 319981 ctgtggaaac gccgctttcg aatgccggag attatgtaag gctcagggcg gagatggatt 320041 taattgtcgc gttttcttcc tgcccgattg aaaaagggaa atgcaatggc gacagtgtga 320101 catccatacg ggttgaagtc agctgatctc tcttgttcac agtgaatgaa gacctgtgct 320161 atatttaata gggatacata acagtcatga ttcattttca ttgatttagg gaaatgatca 320221 gtaataaggg aaaatgtaca ggaggaatga ttgggatgag catgcaggaa aagattatgc 320281 gtgagttaca tgtgaagccc tcaattgatc caaagcaaga aattgaggac cgagtcaatt 320341 ttttaaaaca atatgtaaag aaaaccggtg ctaaaggctt tgtattggga atcagcgggg 320401 gccaggattc aacacttgcg ggaagactcg ctcagcttgc ggtggagagc attcgcgagg 320461 agggcggaga cgctcaattt atcgcggtcc gtcttccgca tggcacacag caggatgaag 320521 acgatgccca gcttgctttg aagtttatta agccggataa atcatggaag tttgatatta 320581 aatcgacagt cagcgctttt tctgatcagt atcagcagga aacaggcgat cagctgacgg 320641 actttaataa aggaaacgta aaagcaagaa caagaatgat cgcgcaatac gcgatcggcg 320701 gccaggaagg tcttcttgtg ttaggaacag accatgctgc tgaagcagtg actggtttct 320761 ttacgaagta cggtgacggc ggagcagacc tcctgccgct gacaggcttg acgaagcgcc 320821 agggaagaac cttgctgaaa gagctgggtg caccggaacg cttatactta aaagaaccga 320881 ctgccgatct gctcgacgaa aaaccgcagc agtcggatga aacagagctt ggcatttcct 320941 acgacgagat tgacgattat ctcgaaggaa aagaagtatc agcgaaagta tcagaagcgc 321001 tggaaaaacg ctacagcatg actgaacata aacgccaggt tccggcgtct atgtttgatg 321061 actggtggaa ataagttgaa gaaagcccgc tctcggagcg ggcttttgtc gtgtacagaa 321121 gctttatttg atgcggatat gattcagctt taccattaat ctgtcggcga accttcggag 321181 gctgcctctt gtatcaggat ctaatgggag ttcggctctc gcggcaatgt tctctgccac 321241 atcctgaatc gacaggttgt ctgtttgaat gtggtcctca aaaatgggtg atgataatcc 321301 ttcaacacag cggtcaattt gtttggcggc ccatgagttt tttccttctg ctctggtgcg 321361 cagccttttt aacaaggttt cctttgaagc cattagtgta aagtggtgaa cgatcctgcc 321421 ttcctgtctg agcctgccga tgatctcatt gaagtattca gggtgtacaa tcgtcatagg 321481 cacaataagg atgccgcggt atgtatctgt cagagaagct agcaaactgt aattgaacgc 321541 ccgccataaa ggatagcttt gaaaatcgtc ctttgcgatc tcctgcggca ccatggagcg 321601 cagcgcaaaa cccattttct cgggatcata cacgtaagat gggttcagcc ttctgtgcag 321661 ttcgaaggct gtttgtgttt ttcccgaacc gaatgccccg tttatccaaa tgatcatcgc 321721 catttctccc ttcctattta tcatacagaa aaagaccctt ccatcgaaga gtcagctgga 321781 aaaacaataa aggcggaagg ttttaacgct tttttgcgtc gaagtattaa aatacctgca 321841 gaaatgttgt acaatgaatg tcattcaggc aaaaatggct acaacaaagc gcactataag 321901 cttgaccggt aaagccggta tctatataaa tattcgctaa ataagcatat aatgaatata 321961 taatttcatt ccttaggagg atttcgccga agatgaacgc taaacgagcc atcccagtaa 322021 gagaaagaaa tatcgtcctg atcggattca tgggtgtagg aaaaacaaca atcggccaat 322081 tggtcgctaa aaaattatat agagatttta ttgatattga ccagcagatc gaaaaggatt 322141 tcaatatgtc aattcctgag atatttgaga aaaagggaga agactttttc cggaaaacgg 322201 agaaggaata tattttagac atctgccatc ataaacgatt caaaatcgta tctctgggcg 322261 ggggatcttt taaacaagaa gaaatcagaa attgctgtct ggaaaactgt ctcgtgcttc 322321 atctggacct gtcatgggag aactggaagc agcgcgcgga tttattgatc gaaagccgcc 322381 ctgtactgca taaccgttca atggatgaaa tggaacagct gtttaacgaa agaaaagtca 322441 tttatgacaa gcacaattca aaagtggcaa cagacaacct ttccccggaa gaggttgccg 322501 attacattgt tgagacatta aaaattggct gggatcttta tcagccgatg taaaaagccg 322561 tgcgcagcgc acggcttttt ttatcgtttt atcccttgta tcaaaatcgc ttttaaacaa 322621 aaggagatgg gctgtccgtt ttggttcaat gtaatacaga acgtgtcgcg tgcttcgtct 322681 gatgcgtgat tcaagtgggt aatgatttgt ttttctcggt cagcgggggt tccgcctcgt 322741 ttgatccagc tatcgtattg aatcggcaag ttccactttt ggatgtcttg ataggccagt 322801 tgattggcgc tgaacatcgc ctgccattct gataatgagc tttcacgaac atgggaaggg 322861 tctcgaagcc ggttcaaatg attgacaaac tcatcaagaa cgggatcttc aggcgcgtaa 322921 tgatcaacta agagaaaacg tccgtcctgt tttagtacgc gtgcaacctc tctgacagct 322981 ttgcggacat ctgaaaaatg gtgggctgcg tatcggcagg tgatgatgtc aaatgaatcg 323041 tcggggaagg ggagtgactc tgccgttcct tgctgaaagc gtacgttttc aactcctttt 323101 tcttgcgcga aggaggacgc aacctcaacc atctctttcg ttgcatcaac accgatgcac 323161 tcctgtacat aaggagaaaa tgccagcgcc gtatggccgg cgcccgctcc tatatccagc 323221 actcgatgct ctgcccggca ttccgctgtt ttgatcatca accccaaatc ttccccctcg 323281 gcaaatacct tttcatcccg atacatctcg gcgtttttag aaaacggtgt ttcatttgtc 323341 atttgaacca gctccttctt ttcgtaaatg atgatatgga ttatgttagc aatttctgtt 323401 atgattcgtc caagatataa aaatgatgaa aatgataggt tcaacctatg gaggctgaaa 323461 tggatattaa agtgatggaa tatgcagcgg aaattgcccg gcgccaaagc tttacaaagg 323521 cggcggaaca tcttcatatc gcacagccgt ctctcagcca gcaaatcaaa aagcttgagg 323581 ctgagctggg gcttaccctt tttcacagat cccatggctc tgttacactg acacctcacg 323641 gcaggcgttt cattgaaaaa gccgaggaca tcattcgttc cagagatgat ttgcttcggg 323701 aaatgcagga gcgatcacag ggaatcggtc ataaattatc catcgggatt cctgctgtaa 323761 cagggagata tctctttcct ccgctgctga agcagttttt ggcgcgctat cctcatgtgg 323821 aggttcagct tgttgaaaaa gatccggttt cattagagaa gatgacggca aagggagaag 323881 ttgacctttc tgttttatcc ttgcccatcg aggatgaacg gctctccatt acacccttgc 323941 tcacggaacc ggttgttctc gcggtgccga aggaaaaaca aaggtggatg ccgccggaat 324001 tggtcgcgct gattgagaaa gcgctggaag aagatgaggg acgccagccg tgtgtgccga 324061 ttgacatggt aaggaacgtg ccctttattc tgttaaaaga aggcttcggc tttcgcagga 324121 cagttctcga tctctgtgcg gaaagcggct ttaagccgaa tgctgccttt aagacgagcc 324181 atattgaaac cgcccaatct cttgtggcta acggattagg tgtgacaatg gcaccgaata 324241 tggtcagaag ggataaagat ccgggtgtga tctatttatc gattcaatcc gcgccatcac 324301 gaaccctcgt ctttgtcttt ttaaagaacc gctatgtcag tctgacggcc caggccttta 324361 tggaactaag ccgggaaagt cttaaacaaa cgtttgatga aggctgtctg ggaaacaaag 324421 atgaaaatat ttagaaaaca aagacgaaac gtggtagtat aggaatacaa actaaatctt 324481 ataaaacaaa ggggaataat cggaaatgca actattcgat ctgccgctcg accaattgca 324541 aacatataag cctgaaaaaa cagcaccgaa agatttttct gagttttgga aattgtcttt 324601 ggaggaactt gcaaaagtcc aagcagaacc tgatttacag ccggttgact atcctgctga 324661 cggagtaaaa gtgtaccgtc tcacatataa aagcttcgga aacgcccgca ttaccggatg 324721 gtacgcggtg cctgacaagg aaggcccgca tccggcgatc gtgaaatatc atggctacaa 324781 tgcaagctat gatggtgaga ttcatgaaat ggtaaactgg gcactccatg gctacgccac 324841 attcggcatg cttgtccgcg gccagcagag cagcgaggat acgagtattt caccgcacgg 324901 tcacgctttg ggctggatga cgaaaggaat tcttgataaa gatacatact attaccgcgg 324961 tgtttatttg gacgccgtcc gcgcgcttga ggtcatcagc agcttcgacg aggttgacga 325021 aacaaggatc ggtgtgacag gaggaagcca aggcggaggt ttaaccattg ccgcagcagc 325081 gctgtcagac attccaaaag ccgcggttgc cgattatcct tatttaagca acttcgaacg 325141 ggccattgat gtggcgcttg aacagccgta ccttgaaatc aattccttct tcagaagaaa 325201 tggcagcccg gaaacagaag tgcaggcgat gaagacactt tcatatttcg atattatgaa 325261 tctcgctgac cgagtgaagg tgcctgtcct gatgtcaatc ggcctgattg acaaggtcac 325321 gccgccgtcc accgtgtttg ccgcctacaa tcatttggaa acaaagaaag agctgaaggt 325381 gtaccgctac ttcggacatg agtatatccc tgcttttcaa actgaaaaac ttgctttctt 325441 taagcagcat cttaaaggct gataaatgtg aaaagccgcc gcatatcatc aggcggtttt 325501 tttctgcaaa ctgccggaat gagaacagac tggagacgaa tagatatgaa acaaagaatc 325561 attgatgaat taaaacggat cgagcagtca tacggagtca aaatcgtgta tgccgtcgag 325621 tcaggaagcc gcgcatgggg atttccctcg caggatagtg attacgacgt ccgctttatt 325681 tatgttccga aaaaggagtg gtacttttca attgagcagg agcgtgatgt cattgaggaa 325741 ccgattcacg atttgctgga tatcagcggc tgggagctga gaaaaacgct tcggcttttc 325801 aaaaagtcaa accctccgct actcgaatgg ctgtcctcag acattgtgta ttatgaagca 325861 tttacgaccg cagagcagtt aagaaaactc cgcacggagg catttaagcc tgaagcaagc 325921 gtgtatcact atatcaatat ggcgagaagg aacgtcaagg attatctaca aggacaagag 325981 gtcaaaatta aaaagtactt ctacgttctt cggcctattt tggcctgcca atggattgaa 326041 aagcacggaa ccataccgcc aatggacttt actgttttga tgaatgaact tgttgctgaa 326101 cccgagctga aggctgaaat ggaaaccttg cttgaacgga aaagaagagg ggaagagctt 326161 gacctcgaag caagaatcga tgttattcac caattcattg aaacggaaat cgaaagaatc 326221 atggaagcgg caaaagaact gaaggcagag aaaaaagata tgacatctga attgaaccgt 326281 ttgcttttga atacggttga agaagtgtgg aaggatggag gaagctgatg ttttttgtcg 326341 cttccttttc tcctttattc gacagaatcc ccccccgact ttctaactat ctgattgtgg 326401 caaacccaca aaaataatca gaatctttgt attttgagaa tattgtgaac gctggttttg 326461 tccatttaca ataaactcat acaaatactt cttagattgc ggggtgttga ggttggaagt 326521 gatcacaaga gattttttct tatttttatc caaaagcggc tttctcaata aaatggcgag 326581 gaactgggga agtcgggtag cagcgggtaa aattatcggc gggaatgact ttaacagttc 326641 aatcccgacc attcgacagc ttaacagcca aggcttgtca gttactgtcg atcatttagg 326701 cgagtttgtg aacagcgccg aggtcgcacg ggagcgtacg gaagagtgca ttcaaaccat 326761 tgcgaccatc gcggatcagg agctgaactc acacgtttct ttaaaaatga cgtctttagg 326821 tttggatata gatatggatt tggtgtatga aaatatgaca aaaatccttc agacggccga 326881 gaaacataaa atcatggtca ccattgacat ggaggacgaa gtcagatgcc agaaaacgct 326941 tgatattttc aaagatttca gaaagaaata cgagcatgtg agcacagtgc tgcaagccta 327001 tctgtaccgg acggaaaaag acattgacga tttggattct ttaaacccgt tccttcgcct 327061 tgtaaaagga gcttataaag aatcagaaaa agtagctttc ccggagaaaa gcgatgtcga 327121 tgaaaattac aaaaaaatca tccgaaagca gctcttaaac ggtcactata cagcgattgc 327181 cacacatgac gacaaaatga tcgactttac aaagcagctt gccaaggaac atggcattgc 327241 caatgacaag tttgaatttc agatgctgta cggcatgcgg tcgcaaaccc agctcagcct 327301 cgtaaaagaa ggttataaca tgagagtcta cctgccatac ggcgaggatt ggtacggcta 327361 ctttatgaga cgccttgcag aacgtccgtc aaacattgca tttgctttca aaggaatgac 327421 aaagaagtaa aaaaggagag attatcatga caacacctta caaacacgag ccattcacaa 327481 atttccaaga tcaaaacaac gtggaagcgt ttaaaaaagc gcttgcgaca gtaagcgaat 327541 atttaggaaa agactatccg cttgtcatta acggcgagag agtggaaacg gaagcgaaaa 327601 tcgtttcaat caacccagct gataaagaag aagtcgtcgg ccgagtgtca aaagcgtctc 327661 aagagcacgc tgagcaagcg attcaagcgg ctgcaaaagc atttgaagag tggagataca 327721 cgtctcctga agagagagcg gctgtcctgt tccgcgctgc tgccaaagtc cgcagaagaa 327781 aacatgaatt ctcagctttg cttgtgaaag aagcaggaaa gccttggaac gaggcggatg 327841 ccgatacggc tgaagcgatt gacttcatgg agtattatgc acgccaaatg atcgaactgg 327901 caaaaggcaa accggtcaac agccgtgaag gcgagaaaaa ccaatatgta tacacgccga 327961 ctggagtgac agtcgttatc ccgccttgga acttcttgtt tgcgatcatg gcaggcacaa 328021 cagtggcgcc gatcgttact ggaaacacag tggttctgaa acctgcgagt gctacacctg 328081 ttattgcagc aaaatttgtt gaggtgcttg aagagtccgg attgccaaaa ggcgtagtca 328141 actttgttcc gggaagcgga gcggaagtag gcgactatct tgttgaccat ccgaaaacaa 328201 gccttatcac atttacggga tcaagagaag ttggtacgag aattttcgaa cgcgcggcga 328261 aggttcagcc gggccagcag catttaaagc gtgtcatcgc tgaaatgggc ggtaaagata 328321 cggttgttgt tgatgaggat gcggacattg aattagcggc tcaatcgatc tttacttcag 328381 cattcggctt tgcgggacaa aaatgctctg caggttcacg tgcagtagtt catgaaaaag 328441 tgtatgatca agtattagag cgtgtcattg aaattacgga atcaaaagta acagctaaac 328501 ctgacagtgc agatgtttat atgggacctg tcattgacca aggttcttat gataaaatta 328561 tgagctatat tgagatcgga aaacaggaag ggcgtttagt aagcggcggt actggtgatg 328621 attcgaaagg atacttcatc aaaccgacga tcttcgctga ccttgatccg aaagcaagac 328681 tcatgcagga agaaattttc ggacctgtcg ttgcattttg taaagtgtca gactttgatg 328741 aagctttaga agtggcaaac aatactgaat atggtttgac aggcgcggtt atcacaaaca 328801 accgcaagca catcgagcgt gcgaaacagg aattccatgt cggaaaccta tacttcaacc 328861 gcaactgtac aggtgctatc gtcggctacc atccgtttgg cggcttcaaa atgtcgggaa 328921 cggattcaaa agcaggcggg ccggattact tggctctgca tatgcaagca aaaacaatca 328981 gtgaaatgtt ctaagcggga ctaaatgggc atcctccctg cgggggtgtc catttcatcc 329041 atatactata aaaaagagga ggaagtgcca tagaaaacac acagctgatt atttcgattt 329101 gtatttatat ggcgggaatg ctgctaatcg gctactttgc ttacaagcgt acgtcgaatc 329161 tgacggatta tatgctggga ggacgctctt tgggtccggc agtaaccgct ctcagtgccg 329221 gcgctgccga tatgagcggc tggctgctaa tggggcttcc gggcgccatg ttttctactg 329281 gtctgagcgg cgcttggatc gtcatcggac tttgccttgg agcgtgggcg aactggcttt 329341 acgtcgcacc acggctgaga acctatactg aaaaagcggg gaattctatt acaattcccg 329401 gattcctgga aaatcgcttc ggagatcaaa caaagcttct cagactgttt tcgggaattg 329461 tcattttagt ctttttcacg ttttatgtat cgtccggaat ggtgtccggc ggcgtcttat 329521 tcaacagcat cttggggatg gattatcaca ccggcctgtg gattgtgacg ggtgttgttg 329581 tggcatatac cctgtttggc ggctttttgg cagtcagctg gacagatttt gttcagggga 329641 ttattatgtt tgccgcactc attcttgtgc cgatcgttac gtttttccac acgggaggag 329701 caggtgatac agttgctgaa atccgctctg tagatcctga tatgtttaat attttcaaag 329761 gaacgagcgt ccttggcatt atttctttgt ttgcctgggg gctgggatac tttggccagc 329821 cgcatattat tgtgcgtttt atggcgataa cgtctgtcaa agagatcaaa agagcgcgca 329881 gaattgggat gggctggatg attttgtctg cagtaggcgc agtgctgacc ggtttgggcg 329941 gaatcgctta ttaccatcag cgcggcatga cactgaagga cccagagacg atttttattc 330001 aattagggaa tatcttgttc catccgatta tcacgggttt tctgatttca gcgattttgg 330061 ccgcgattat gagtacaatt tcttcccagc tgcttgtgac atcaagctct ctggtagaag 330121 atttgtataa gtcgatgttc agacgctcag cttcagataa agaactggtg tttttaggcc 330181 gactggctgt tctggctgtt tcaattgtcg cgttggttct ggcttgggag aaaaataaca 330241 ccatccttgg attggtcagc tacgcgtggg cgggcttcgg tgcatcattc gggccagttg 330301 tactgctcag tctgttttgg aaacgaatga ccaaatgggg ggcactcgcc ggcatgattg 330361 tgggagcagc gactgtaatc atttgggcga atgccggtct ttcggacttt ctgtatgaaa 330421 tgatacctgg ttttgctgcg agtctattat ctgtcttttt tgtcagcata ttgacgcagg 330481 ctccgtcaca agctgtcaca gaccagttca acgactacca agatacaatg tcgcaataaa 330541 gatcgaaagg aggaggaagg ggctgtccct ttttcctctt ttctcctttt aagcggccat 330601 ttttttcttt tggaaacaaa cgtatttttt tctatacaaa aagaccccgt atggatatga 330661 ttaaagtaaa aaaagtatag gagaaaaagg tatggaagag cttttagaga gagttttttc 330721 attttcagat gttgataagc taattgattt tattagctat gaactgcaaa agccagtgat 330781 actggaaagc gcggatttct ttttgttagc ctataattct tactatatta accattttga 330841 ttctgccaac cagcagacta ttttttcgaa aaagtgtccg gtccagattt ttgagaggtt 330901 tctgaaggac ggaattattg aaaaattgaa aacagagcct gagccttttc gcgtcaataa 330961 aattgaaagc attgggttaa accagagggt ggtcgtgagt gcaaagcaca aaggggaagt 331021 catgggctac atctggattc aggagctgga ccaaaatctg acggatgaag agctcgactt 331081 tttgtacgag acctccttcc atgtcgggaa aatcatttat aaaacgaata aattgaaaca 331141 ggaaaaggaa gaaaaagcag aggatctcat caaacgggcg atctatcagc aatttacctc 331201 tgagaaggaa ctcagacggg aagctgaaag gatcaacacc gtgctgcctt ccatgttttc 331261 agttgttatc ctgcacgccg caaatgggga tggggaagcg gttgaggatt taaaggaaaa 331321 tatcaggtcg tacctgaatt tacgggataa ggtcagtcat gtcttaacga tcgaatcaaa 331381 cattgtcatc gtcgtagcga gtttttccca aaaaagctcc gtctcctcag cagcttctga 331441 gtttattaac aagctgttaa cacattttca ctttcaaaaa atacctaccc ctatttatat 331501 cggtatcgga aacgaatata atcacctatt aaaacttggc aagagctaca cagaagcact 331561 tgaagtcatc aaagccgcag aaatcaccgg caatcaggaa aacattccat atgaatatgc 331621 caaactcggc atttaccgct atttagaaag catcgaacag aaaaatgaat ttttagaata 331681 cgagaataaa gatttagctt tattaaaagc aaaagacgaa gaaagcagca ctgagctgct 331741 caaaaccttg gaaatctatc tcctcaacaa ctgcaaaaca aaaccagcgg cagaacagct 331801 gtttattcac caaaatacat tgaattaccg catcaaacag attactgaga tgacgtcgat 331861 cgatttaagc gatttcagaa cgcggtgcca gctctatctc gatttgatgc tgatgaaaaa 331921 gaaataaaaa agaaaccagt acttgtactg gtttcgtctt cacttaaaat cctctgtaaa 331981 catacggatc atcaggtttt ttaatggtat tccagtcagt tactttgacg acagggagag 332041 ttgacttgaa tggctggtaa tattctgagg ccagagtgcc cttaatgtga atccattcat 332101 catccttgat gtccatgtcc ttcggaaatt ccacaagcat cccgtacacg ccggaatcag 332161 cgatacagtg aatgatgcca aaccttaata cgaacagctg atttttgtta attgcgtttc 332221 ctttgtaagc aaatccatga aattctatcg tccgtccgag aaattcaccc ggatagttat 332281 agatggtttc cattcctttt aggaaatcgt catcggtcag agaaatctct tttttgctgg 332341 aatacttatt aaacagctgt ttcatttgtt tgtcatagct gtcttgcgcg taataaaggc 332401 tggcatcagg ccgcaaatac tgtgtttggg agtagtgatc tccgctctcc atcgccttaa 332461 acgagaaccc ttttgttttg actatggatg agtcaagcgt tgcaatcggg aagaagatgc 332521 ctgacaccaa aggaaaaaga aaaacaacat aaatcaaata acgctgataa aatggcttgt 332581 tttgttcatg gtcatgctcg tgatcatggc cgcacccgca atcatggtca tggtgatgtc 332641 cgcttttttc aggcgacttg ataaatagat atgcttggac ggcggtcaga atggccagca 332701 ggaagatcgc aataaaggaa agataggcat atttcatatt gatatatttt gttagatttc 332761 ctgaggcatg cagatgataa aagaaaaacg taaatcccat cagcaccaat aaacgaaaca 332821 tccaatcacc cctttaccag tagtgatccc gctaaaacaa tcacgacaat gtatgtaatc 332881 agcaggaaaa caaatcgttt tttgaaggcc gcaagcatca tcaatagatt cttaatatcc 332941 accattgcac caaagacgag aaaggcgatt aacgatccta atgaaaacgt gctgctgaag 333001 gaagacgcga tgaacgcatc aacttctgaa caaagcgaca ggacaaacgc cagacccatc 333061 atcacgaggg aagaggatac atcattctgc ccgatcgcaa gcagagtgga tgttttgaca 333121 tacgtctgca tagcggctgc gataaaggcg ccgatgatta aatatttccc cacggagaaa 333181 aattcatcaa tggcatgccg caaggtcccg cccagttttt ggagcaaggt gccgtgatga 333241 tgatggtggt gcccgggttc atcaggcttt aaaagctggt tatccttaaa ttgataggat 333301 aagatgaccc cgatgatcag cgaaacggcg agagccagtc cgcctctgta aaagaccacg 333361 ctccatctat tcccgaacgc aatataagta gaaaataaaa cgataggatt aatgataggc 333421 gcggtcagca tgaaagcaac gcccgcatgc agaggaactc cctttaacag aagccgcctc 333481 gtaatcggga tgatgccgca ttcgcaggcg ggaaataaaa cgccggccag cgcaccgaat 333541 aaaacggcga gaaaacggtt tttcggcatg attcttgcaa tcatttcttc agaaacaaac 333601 atttgaatga ttccggaaag tatgacgcca atcagaataa acggaatggc ttctattaaa 333661 atgctgataa aaatagaatt cagctgaaga aaagatgatt gtgctgtcac aataaaacct 333721 ccgctcatgt taagctgcct ttcttatgat accagaaaaa aaggcactgc ttgtttgacg 333781 gaggagggga aaggatcgtt tcactttggt taggattcca aaaagccgag taggatactg 333841 cctgtttctg cagcttcttt tccgagccaa atcaggtgtc cccatgagtg aagcaaacag 333901 agaacagcgc cacgaatgtg ctcttttgca tgatgtgcat gtgacaagtc aaccaatccg 333961 tcataaacac tttgcataat cagcacggga catatgatgg cttgcaggtc ttttaaagag 334021 acagcggcgg tttgtgacaa gtcaatcaga aatccttcac ccgagcgctg ccggctgttc 334081 attttccgaa atgcttctat gtctttttca ttcatcaagg acttgattcg ctgaaacgga 334141 agcgtgctga attgggggct catagctcga aacatcaaac gcgggaaagc gttattcaag 334201 gaagaaatca gcttccatat ccacttttcc accggcgggc ggaagagaat ttcccccaat 334261 ttatattcag tgtcttttgg ggtgagccac tctttggtga ctgcggattg cagggtcaat 334321 gtatttactc tttccggata atgtgaggca aagcatatgc cgctcggccc tcctgctgag 334381 atggcgatca catggacact ctcgatttgt agatgatcta ataatttcac atagaaacgg 334441 caggcattgg caagactttt tccaatttct tttgacgtcc gtccatagcc aggccttgaa 334501 ggcgtaatga tggaataccc ttgttcaatc aacgctgtgt atccgaattc ctcgtaacaa 334561 tttgaatgcc cgccatgcat gacaaggatc ggagttccct tgcctgtcac agaatattct 334621 agtgtaccgc catcgaaggt gatcgtttca actcgtcttt tcatctgttt cacccaattg 334681 gtttttgcct attatagagt tttcagcaat tgaccacaag gtagaagaaa tgaataaaca 334741 aaggcccttg aaatatgata tactttgtat tgatattcat tctcaattaa aactttgata 334801 tagatgtgaa cgggaggcag gacggatggc tgagaatcaa gaggtatatg acgttacgat 334861 tataggcggg gggccgatcg ggctgtttac tgctttttac tgcgggatgc gggagctgaa 334921 aacaaaggta atcgaatttt tgccgaagct cggagggaag gtgtctttat tctttcctga 334981 gaaaatcatt cgcgatatcg gcggcatacc ggggattgcg ggaaagcagc tgatcgagca 335041 gctgaaggag caggcggcaa cgtttgatcc tgatatcgta ttgaatcagc gtgtgaccgg 335101 gtttgaacgc ctagatgacg gcaccattgt tctgacgggt tctgaaggga aaaagcacta 335161 tacaagaact gtgattttgg cttgcggcat gggtacactt gaggtcaatg agtttgacag 335221 cgaggatgcg gcccgatatg cgggcaaaaa tcttcattat ggagtggaga agctcgatgc 335281 gtttaaaggg aaacgcgtgg tgatatcagg cggcggagat actgcggtcg attgggctaa 335341 tgagcttgaa ccgattgcgg cgtctgtgac tgtcgttcat cggcgtgagg aattcggcgg 335401 aatggaaagc agcgtgacga aaatgaagca atcatcggtg cgggtgctta cgccttatcg 335461 gctggagcag ttgaacggag atgaagaggg catcaaaagc gtgaccgttt gtcatactga 335521 gtctggccag aggaaagaca tagaaattga tgagctgatc attaatcatg ggttcaaaat 335581 tgatctcggg ccgatgatgg agtgggggct ggagattgaa gaaggaaggg tgaaagctga 335641 cagacatatg cgaacgaatc ttccgggcgt gtttgtggcg ggcgacgcgg ctttttatga 335701 aagcaagctg agattgattg ccggcggatt tacggaaggc ccgacagcgg tcaacagtgc 335761 caaggcttat ctggacccta aggccgagaa tatggcgatg tattccaccc atcataaaaa 335821 attggtgcat aaataaaaca gcccttgagg aaaagggctg cttgccatca ggtgtgaagg 335881 agttttttct ctgcatgttg attgtggatg aaagctagca attcatcctg ttcttgtacg 335941 gctgtgaatc cataaatgcc ggcagctgag tcatcgccta tgcagacgat aggagggcgg 336001 cttgctgacg gttccggcaa aatgccaatt tgttcgccac cattgatcaa ttgctgaacg 336061 gacagcttgt ttgggcaaat gaccatgtgc agcggggatt cactgatggt acgctgaatc 336121 atgtgggtga accggtcatc tatgacgttt tcatgagtga tataaaacga acaggattca 336181 tgcttttgca tgttttccac tgcatggcgg ctcccgacaa caagacgttt ctctgaatca 336241 ggctgaatgg cggtgacaag aaagccccgt ttctcaagct ctgtctttgc ttgctcagat 336301 gctgcactca gtttggctgt cagctggcgg atgtcgattt tctgagaagc cagtgctctg 336361 aaaaattcac aaaccgcccg gcgcgatgtg aaaaaaacgt cttcaaaggt gccaatcttt 336421 cgaagaattt cttcattgac aggcatgttt tcggtccgcc atttcggcca ctcgatgaga 336481 tcggcgccgg aatcgcgcag cttgtctgca agcgggtctt catcttcgcc atgagtcaca 336541 accatcaaat gccgtccgat gagcggtttg ctttcaaacc agctgtgtgt ttgaaagttg 336601 acgatgtctc cgatgacgat aatcgcaggg tttgtaatct ggtgttcctg cactttttgc 336661 tgaatgttct caagtgttcc tttcacactc cgctggcggc cccacgttcc ccattggatg 336721 acaatgacag ggacagaagg cgatttcccg tatgaaataa gctgctggca aatataagac 336781 aagttcttga cacccatgta aaaaacaagg gtttgaacgc ttcgggccag cccttcccag 336841 tcaaggttcg gcgtgccttt taatgattta tcatgcgctg taatcatggc aaaagacgat 336901 gcaaaatccc gatgcgtgac ggggatgccc gcatatagcg gcgctgcaat tccagaggtg 336961 attcccggca ccatttcata gcgaatgccg tgctcatgaa gagcatctgc ttcctcgccg 337021 actctgccga atacgctcgg atctccgccc ttcaagcgaa cgacggttaa cccatttaat 337081 gctttttcaa ccagcagggc gttaatttct ttttgtttca taaaatggcg gtttggcagt 337141 tttccgcaat aaataaactg gcagtccggt gatgcaaatt cgagcagctt cgggttggcg 337201 agccggtcat ataaaatcac atctgcttcc ttgagcgcct gttttccttt gatggtgagc 337261 aggcctgggt cgccgggtcc ggctcccacg aaatatacga ttccgttctt catgatcatg 337321 tcatccttcc gtcactgtaa aaaatgaagg accactagaa aagtgatccg gtcttttgat 337381 caatatacga gataaacatg ttctccttcg atcagcgttt catatgtttt gacgcatccg 337441 tggtcaggtt cttggacgat tccgtcttct aaggaaattt tccagtcgtg catcgggcag 337501 aaaacatatt gaccgctgac gatgccttct gccaggacgc cgcccttatg cggacagcgg 337561 ttttcaatgg cgcggatgct tccgtctgaa agcttgaaaa ccgcgagctc cttatcttca 337621 atatacactg ttttgcctaa ttgttcaggc aattcttcaa tttttccgat acatactttt 337681 gttacgtctt tgtttaccat gtccattcct cctcaatgat agtttttgtc attatgatgt 337741 ggtcacgaca ttttcaaata attctttaga ggtttgttta tcctctaaaa agtctttcca 337801 cggatccttg tggacagaga gtgtttcatt cattcggccg ttcagctcct gccgcttttc 337861 cggatcgttt aacacggatt ggacatggga taaaccgacg cgctcaagcc atgcggacgt 337921 acgctccaga tagtttgcgg tttccctgta atattgcagg taagcgcccg cgtattctaa 337981 gacttcttca tttgttttca ccttcatcag caaatcgccg gcacgcaaat gggttccgcc 338041 gtttccgccg acataaagct cccagcctcc gtcgatgccg acaacgccaa ggtccttaat 338101 gccggattcc gcacagtttc gcgggcaggc agacacggcc attttgactt tgtgaggcgt 338161 gttcagccct tcgaattttt tctcaagcgc aatgcccagt gccatggagt cttgtgtgcc 338221 gaagcggcag aattgctcgc ctacacatgt tttcactgtg cggagcgttt ttccgtacgc 338281 gtagcccgat ggcatatcaa gatcttccca taccttcgga aggtcttctt ttttcacgcc 338341 gataagatca attcgctggc cgcctgtcat tttcacgagc gggatctcat atttgtcaac 338401 gacatcggcg atcttgcgca aatctgtgga gttggtcacg ccgccgtaca tccgaggaac 338461 gactgagtat gttccgtctt tttgaatatt ggcgtgcatt cgttcattaa caaagcggga 338521 tgtccggtca tcctcgtatt tggttggatt gatcatgcct aagtagtagt tcagagcggg 338581 tcggcattta gaacagcctt ctggcgtttt ccagccgagc acattcatga cttctcttgt 338641 atgtgacagc cctttggctt tgatttcttc tacgacttca tctctcgaca atgtggtgca 338701 gccgcaaatg gcttcttttt gcgctgacgc atcaaagtct gatccgagcg tatgctggag 338761 gatttcttct acgagcggct tacagcctcc gcatgagcgg gatgcgccgg tgcatgcttt 338821 gatttcgtcc gttgacgagc agcccttttc ctgtatggct tgaataatcg caccttttga 338881 cacgccgtta cagccgcaga tgatttcatc gtcgctcatc gctgcggtta tgcttgtgcc 338941 tgcttcctgg ctgaggggct gtaagattga tattttagag gtttcagaga tatcggcttc 339001 tttttgaatc atagaaaaca ggcgattgcc ttcgctgctg tcgccgaata aaacagcacc 339061 gacaatttga ttgcctctca ggacaatttt tttatagatg ccgtcctgct catcgaagac 339121 tttaatcgct tttttctcct ctgattcgtt aaagtcaccg gcagagaaga cctcgacgcc 339181 tgataccttt aactgtgtgg agagaacgga gccctcatac ggttttgttt cgatgccgca 339241 catatgcttt gccagcactt ttgcctgttc atacagcggc gccacaagcc cgtaggcgat 339301 tcctcggtgc tcggcacatt cgccgaccgc gtaaatgtgc gggatttcag tctgcatata 339361 atcgttgacg atgatgccgc ggttaaccgg aatgccgctc tcggccccga gcgttgtatt 339421 tgggcggatg ccgacagcca tgacgactaa atcagcttca atgcttgtgc catccttgaa 339481 tcggaggcct tcgacacggt cgtcaccgac aatttcttct gtttgctttt caagtaaaaa 339541 ggtcatacct tgtttttcta actcgttttg cagcaggcgt cctgccgttg catcaagctg 339601 gcgctccatc aggaatgggg caaggtggat gacggacacg tccatgccga gattcagcag 339661 tccgcgagct gcttccaaac caagtagtcc tccgccgatg acggcagctt ttttatattg 339721 ttttgacgcg gcgagcattg tgtctgtatc ttttatgtcc cggaaagctg tgacgccttt 339781 tttgtctgcg cccggaatcg gaaggataaa agggaccgat cctgtcgcca ggatcaattc 339841 atcgtaaggc tggattctgt ctgcatctgt gatgactgtt ttgttttccg tgtccacttt 339901 gatgactgtt tcatttgtat acaattgaat gttgttttct tcgtaccagt cccaatcgtt 339961 taacgtaata tctttaatat ctgtatcgcc ttgaagcact tttgacaaaa ggattcggtt 340021 gtaattggga tgcggttcgg caccgaaaat tgtgatctga aactcgtctt tagcaacact 340081 cagtatctct tcaatggccc ttaccccggc cattccatta ccaacaagaa ctagctgttt 340141 ttttcccatc agatgatccg ctccttatca aatgtttttt ccagcgtagc acagcaaaaa 340201 ggaatattta agatacatgt tataaaatgt aacaaaatat acgaaaagtt ctaaaaattt 340261 tatgaaaaat ttaaataggt atgattcgga cggcgcatac cttaaaaccg ggcattttac 340321 aggctggatc taaggcttcc ccgattaaat cattcacatt ttgagcgtct gcccaatgga 340381 tgggaacaaa aacggtatct tttctgattt gttctgataa tttgctgcgg acggtgatgc 340441 ttccccgcgg cgattctatt tttaccagta cacggtcctc gatattgtag gtcgctgctg 340501 tttgcggatg gatctccata aacgattcaa aatgtctcgc ggcaagggcg gcgctttttc 340561 ttgtttggac gcctgttaag tagtgagaca tgactctgcc tgtcgttaaa taaagcggat 340621 aatcggctgt cggcttctct tttggaacag gtggttcgtt tggaatcaca cttaatgccg 340681 ctttttgatc cggatgagca aatgattctg taaacaagcg cccagttccg ggatgatcag 340741 attccggaca cggccaatga atgccgcctt cacgtctgag cctgccgtat gagatgcctg 340801 aataatcggc aatcccgcct cggctcgctt ctctcaattc attgaaaata tcctccgctg 340861 acgtataaga aaagtagcgg cccttgccga gagcggatgc gagatcacaa atgatctgcc 340921 aatcatgctt tgcttcgccg gggcatggcc ggcttgcttc tcttaatgtc acgcgtcctt 340981 ctacatttgt catggtgcct tcatcttcta agtaagagga ggcaggtaaa atcacatctg 341041 cgtatttcgc agtctcagaa ataaacaaat cgattgcgac aaagaatgtc agtcttctta 341101 aagccttttt cacgagattt gcatttggac tggaaacagc agggttggag cacatgagga 341161 acagtccttt gatgtcgccg tcattgattt tttccatcat ttcataggct gagacacctt 341221 ttcgcgggag ttcatcctga tggattcccc acactttcgc aatatgcgcc cggtgttctt 341281 cgttttcgat agaacggtag cctggaagct gatcggcttt ttggccatgc tctctggcgc 341341 cttgcccgtt gccttgtccg gtgatcgccc cgtagcccga gtaaggtttg ccgatttttc 341401 ctgtgatcag caccatgttt aagaagcctt tcacagccgc tgttccatcg gtttgctgtt 341461 caatcccgcg ggctgtaaac agcatgccgg acgtttcctt ggcaaacttc acagcagctt 341521 ttcttatatc caccagcgag acactcgtct gttcggcgat gtcattcagg tccaacgagt 341581 cagtatgctg cttcagctct tcgaatccat ttgttcgtga ttgaatgaaa tcctcgttta 341641 taagctgttc gtcaatgatg attttgacga gaccgttggc aagggcggcg tctgtgccgg 341701 gtttgatttt cagatgaaga tcggcgattt tcgttgtcgc tgtttcacga ggatcaatgg 341761 caatgaagta agctccgttt tctttcgctt tttcaaaata cggcataatc gtaggctggc 341821 attccgcaat attggtgccg gccagaatga tcacacgggt gtgggggatg tctgataaag 341881 gattcgttaa gcctctgtcc gcgccgaatg tttggttggc tgcggtggct gctgcggaca 341941 tacaaagtct cccgttgtag tcgatgtatt ttgtctgtaa gcctactcgt gcgaacttcc 342001 ctaacaaata cgcctcttca tttgtaatcg aggcgcttcc gtataccgcc atggcgtcat 342061 gtccgtgttc agtttggatc attgtcactt ggtctttgat atgattcagt gcttcttccc 342121 aggaaacagg cataaactcg ccgtttttct tcagcagcgg ccgggtgatg cgggaggagt 342181 tcaaggcatg ctggtgagca ttcatgccct tgatgcatag ccgaccctgt gtcgtaggat 342241 tatcaatccc gatcgcagtg tactttttgc gcgtgacgat ggtttgttcc acgagctgca 342301 ttttgcactg catgctgcaa aacgggcatt gagtgtcata tgttttttct gattggacgt 342361 cttgctgttt atcacggaaa tatctaagca gtcgttcagt caaaatgcct catcctttct 342421 tatatgcgcc cgtctctaca gtcgggtttt gaatcagtga cagatctgtt tggaggcttt 342481 ccagcagctg tgcccttagg tcttcttcga atagcacttc tctgatatga acgatcccga 342541 gacggtctat ccactgatga acaccttcta agtaatgagc cgtttcccga taatactgga 342601 tcagtccttt gatcatgccg gcagtgctgt cttcgttctc agtcacgcaa aacaaagctc 342661 ctgaacgggc atgagttccc cggacgccgc cgatgtgaat gtcccagcca gcttgtgtcc 342721 gaattgcgcc gacatcttgc agggcggcct cggtgcagtc tgtttcacat gataagctga 342781 tagaaatggg agcgggtaag ggaagcatct caagttgtct ttcgatttgg gctgccagct 342841 gctgaatcga tcgattttgc ccgcatgtac atgctttgat gctttgcagc gcgtgtcggt 342901 gttcattagt gtaaacgggc attttcaggt cttttttcat gttcgggaga tccgcaggct 342961 tgatcccgga aagcttcagc ctttggccgt gagtgatgga tacgtcggga atgctgtatg 343021 cctcaatgat gttggcgatg gttcttagct gctccgcgtt tgtccgcccg ccgtacattt 343081 gcggaatcag gatgcatgtc tcttcagtgg ctggctcagg ctggacaaac ccagggtaca 343141 gcatttccag atagtattga atcgcaggaa cacaagtact gcatccgttt tttgttttcc 343201 agtcaagctg gttcatcact tctgccggat tagtgaatgg cctgcgctga agctcagcga 343261 tgatgtcgtc ttctgtaaaa tcagtacagc tgcaaaacga aggtgtgctg gcgggcttcg 343321 tatattcgct gttggtcatg tatctcaaaa ggtcttcaac gagcggtttg catcctccgc 343381 aggacccagt ggctttggtg cagtgcttga cttcctcaac agttgttaag ctattcgtgt 343441 gcaccgcgtc ttcaatcgcg cctttcgtca ctgtgttgca ttggcaaatc gtttcactgg 343501 aaggcatgga ttcaaataaa gggccgcttg tctccggttc gatgatctgt tttttggcaa 343561 tggagatgtc tcgttgttta agcaggctgt cgagaagccg ctgcttgtca cgggtgtctc 343621 cgaataaaat aacgccggcc agtttgtcat ctacaaaaag cgctttttta taaacgcctg 343681 cttgttcgtc gtagattttg atgctcgtcg tgcgttcatc ctcttggatc tttcctgctg 343741 accacacatc gattccagct atttttaacg ccgcagatgg tgctgagcct tgatattcct 343801 cacatggaac gccgcaaata tgactggcga gcgcttttcc ctgctcataa agcggagcca 343861 ccaatccgta caccgttccg ttatgctcag cgcattcacc aacggcgtag atattcggtt 343921 cgcttgtctg catgaagtca ttcacgatga tcccgcggtt cactttgatt ccagcggata 343981 cagccaattc aatattcggt ttgacgccgg ccgccatcac aatcaagtct gcttttaatg 344041 aagagccatc tttaaaatgg attcggtctg ccttcgtggc gccggaaatg gagacggtgt 344101 ctttctccaa aagaaaggtt aggccttttt gttccagctc tgtttgcagc agccgcgccg 344161 ctgtttgatc gagctgtttt tgcataatgc cggcggagtg gtgaatgacg ctgacatcca 344221 taccgagatg ctgtaaacct actgcagctt ccagtcctaa taagccggct ccgattaccg 344281 cagccttttg aaagtgctgg gccatgttca tcagcgcttg gcagtcttct attgtccgaa 344341 atccatagac accttttttg tctgccccgg ggatagggag aatatgaggg gaggagcctg 344401 ttgccactat taatttgtca tacgacagag tgcgtttccg atctgtgatg acctgctgct 344461 gatctgtatc aatctgaata accgtttcgc ctgtgtaaag cgtgatcccg tgcttgtcgt 344521 accaatcctt gctgttcagt gtaatatcat cgagtgacgc ttcaccctgc aatacagagg 344581 ataagagaat gcgattgtaa ttgggatgcg gctcgcttcc gaaaatgaca atctcaaaca 344641 tgtggcgatt cagctttaat acttcttcaa tacagcggat tccggccatg ccgtttcccg 344701 ctaacactaa tctttgtttc ttcatgtatc agacctcctt tggcgaagct cgtaagtttt 344761 ctcctattaa aaattatgtc acaatgcatt gttaacgcat taaacgtgtc acaaaaactt 344821 acacatgtct tttccagaaa ataatggtcc tatatccttg attcagaaaa tgtaaaataa 344881 tgagggtcta gaaaggggaa tcttatgaag ctgtcggaac tgaaaactag cggtcatcca 344941 ctcactttgc tctgttcctt tttatacttt gatgtcagtt ttatgatatg ggttatgctt 345001 ggggcgctgg gtgtttatat ttctcaggat tttggcctgt ctccttttga gaaagggctt 345061 gtcgtagctg tgccgatttt atctggatct gtgtttcgta tcattcttgg tattttaacg 345121 gacagaatcg gaccgaaaaa aacggcagtg atcgggatgc tggtgacgat gattccgctg 345181 ctttggggga cattcggcgg ccgttccctg actgagctgt atgccatcgg gattctgctt 345241 ggcgtggcgg gagcaagctt tgctgtagcg ctgcctatgg ccagccgctg gtatccgcct 345301 catttgcagg gacttgcgat ggggattgcc ggagcgggga acagcggcac gttgtttgca 345361 accctgtttg gccctcgtct ggcagagcag ttcggctggc acattgtcat gggaattgcg 345421 ctaattccat tattgatcgt ctttattctt tttgtatcca tggcaaagga ttcccctgca 345481 cagccgtctc cccagccgct caaaagctat ctgcatgtgt ttgggcaaaa ggaaacatgg 345541 tttttctgcc tgctgtacag cgtcacattt ggcggatttg tcgggctctc aagcttttta 345601 tctattttct ttgttgatca ataccagctg tcaaaaattc acgcagggga cttcgttaca 345661 ttatgtgtgg cggcggggag ctttttccgg cctgtcgggg gcttgatttc agatcgtgtc 345721 ggcggcacga aagttctttc tgtattgttt gtcatcgtgg cactgtgtat ggccggagtc 345781 agtagcctgc catctctctc aatggttatt gttctattgt ttgtcggaat gatggggctc 345841 ggaatgggaa acggcgcagt attccagctc gtgccgcagc gcttccgcaa agaaatcggc 345901 atggtgacgg gaatcgtcgg tgcggccgga ggaatcggag ggtttttctt gccgaacatc 345961 ttaggatctc tcaaacagat gacaggcaca tatgctatcg gttttatcac gttttcctgt 346021 atcgcgctgc tggcgtttgc acttgtgctt gccgcaggct attactggcg gaaaagctgg 346081 agcgcggaaa gcagcccggc ggatgtttag gattttgacg gacacgcgtt tgtgcgtgtc 346141 ttttttattt tctcttgatt ttcaacagtg aaccgatcaa aataaatagt aattattacg 346201 atttgttagt gagaggagtt ttctgaatga atcaacatac gctgctcccg aaaaaaacgg 346261 agcgtcttca atactttgga tcggtcagtc cgatcaaagg cgagaaacca gtggaaaaag 346321 agaaaatgaa ggacctgcaa aatatcagga aggattattt ttttgacatt cagcatgtag 346381 gtgtagctaa tgtgtcccat ccagtcacaa tcacttctgc catgatgcct gccgagcaaa 346441 caacggctgc gaactttaca atgacttgta atttgccgag aaatcagaag gggattaaca 346501 tgagccggtt aacagagctg ctgcaagtct atcatcaaaa tggctggatt ctctcatttt 346561 cctctcttca gcaatttacg aaagagcttg cagaaaacat ggacacatca tctgccacag 346621 ttgaagtgag gtttccgtgg tttttcgaac ggaaaagccc gaagcttgag aaagcgggtt 346681 tgatgcatgc tgatatattc atgtctgtca cctatcgcaa agatcagccg tttaaacagc 346741 gtgccggcat ctcagcaaaa gtaacgactc tgtgcccttg ctccaaggaa atcagcgaat 346801 acagtgccca taatcagagg ggaacggtca gcatttgggc ggatattcac ccggccgcat 346861 cgctgccaag tgatgttaaa gctgatttgc ttcacgccgc agaatcaaat gcttctgcga 346921 gactgcatcc ggtattgaag cggcctgatg aaaaagccgt gacagaaacg gcctatgaaa 346981 acccgagatt tgttgaggat ctcgcccggc tgattgctgc agatttgttt gagcttgaat 347041 gggtgtcagc ctttgagatt gaatgccgaa atgaagaatc gatccatctt cacgatgcct 347101 atgcgaagct gtgtttttcg aaggaagtgg ataaaatatg aaactctcat tattcattat 347161 tgcagttctt atgccagtca tcctgctgtc agcctgctcc gatcatgcag aagaacacgc 347221 aagtatcaat acaaagaaaa cggtcgaaaa cataacggac gttcgaaaaa cagcaaaaac 347281 aagcattgat tggacaaagc cttcgggcgg agaatacccg gatattaaac agaagcatgt 347341 ctggattgat gtgaatgtga aggagcagaa ggcttacatc aaggaaggaa gcaacaccat 347401 ctatacaatg atgatttctt ctggtcttga tcaaacaaaa gatgatgcta cgccaaaggg 347461 caccttttat gtagagcctg aacggggaga atggtttttc tccgaaggat accaggaagg 347521 cgcagaatac tgggtatcat ggaaaaatca cggtgaattt ttatttcata gtgtgccaat 347581 gactaaggat caaaaagtca tcaaaacgga agcagaaaaa ctaggaacga aagcatctca 347641 cggatgtatc aggctgacca ttccagatgc gaaatgggta tatgaaaata tccctgaaca 347701 tacaaaagtg gtgatcagct gaattgaaaa ccgttgacaa aaaggaaaaa agaccataca 347761 atttaaatcg taacaattac gttttatgat aaatggctta tcattgtctg tgcatctgtg 347821 aaaagcggaa aggcatcgat taaggatctt gctgtcggca aaggcaagga tttgcgatgg 347881 ggaaaaggat taaacgcggt tggagtcttt actgatttag aaatcgggcg gcagcgagaa 347941 atgagcgcga aaagctgctc tacaccattg tacatacggc gaagtattca atttaaatcg 348001 taatcattct attttaatgg aggcactatt atgaaaaaaa ttccggttac cgtactgagc 348061 ggttatctcg gtgcgggaaa aacaacattg ctgaacagca ttttgcaaaa tcgcgaaggc 348121 ttgaaaatag cggttatcgt aaacgatatg agcgaggtga acattgacgc gggcttggtt 348181 aagcaggaag gtggcctttc cagaacagat gaaaagcttg tggaaatgtc aaatggctgc 348241 atttgctgca cgcttcgcga agacttatta attgaagttg agaagctggc aaaagacgga 348301 cggtttgatt atatcgtcat cgaatcgaca ggaatcagcg aaccgatccc ggtggcccag 348361 actttctctt atatcgatga agagatggga atcgatctta caaaattctg tcagctggat 348421 acgatggtga cggttgttga tgccaaccgt ttttggcatg attatcagtc aggcgaaagc 348481 cttctggacc gcaaagaagc attgggggaa aaggatgaaa gagaaatcgc cgacctcttg 348541 atcgatcaaa ttgagttttg cgatgtactg atcttaaata aatgtgattt ggtcagcgag 348601 caagagctcg aacagcttga aaacgttctt cgtaaactgc agccaagagc caggttcatt 348661 cgttccgtca aaggaaatgt aaaaccgcag gagattttgc atacagggtt atttaacttc 348721 gaggaagcga gcggatcggc cggctggatt caagagctga cggcaggcca tgcggaacac 348781 accccggaaa cagaagaata cggtatctct tcatttgtat ataagagacg tttgccgttt 348841 cattctacac gattttaccg ttggttggat caaatgccaa agaacgtggt acgtgccaaa 348901 ggaatcgtct ggtgcgcatc tcataacaac ctcgctttgc tgatgtcgca agcaggtccg 348961 tcggttacga ttgagcctgt atcttattgg gtggcggcgt tgccgaagct tgagcaggag 349021 caagtcaaac agcaggagcc ggaaatcctg gaggagtggg acccggagtt cggcgaccgc 349081 ctaacgcagc tagtttttat cggaactgac ctggatgaag aaacgatcac gaaagagctt 349141 gatcaatgcc tgttgactga gtatgaattt gattccgact ggtcgctgtt tgaggacccg 349201 tttaaatgga agctgaatca atagaaaaaa agccgtccca tggggaacgg ctttttttaa 349261 tgaaacgttt gtttaaacat aatgagcgta ttttttctca aggatattct gaaagaccgc 349321 ggcaatggag cagatggccc aataaatgag agcggtcaga atatacatgg tcatataatc 349381 aaactctctg cccccgatga ttttcgcatg ctggagcaat tccggcactg taatcatcgc 349441 agcgagagag gacgccttga tcaagtcgag caatacattg gcaagcggag gcagcgcaat 349501 acgtatcgat tgcggcaaaa tgatgcccct catcgtctgc caataggaaa gacccagcga 349561 ggatgcggct tcccactgtc ctttttcgac ggatgaaatg gctgaacggt taatttccgc 349621 aatgtaggcg gcgctgttta ggctaaagcc gattaaagca gccgtgacag cggaaaattc 349681 aatgccgata taaggaaacc cgaaataaag gataaacaaa atcaccaaaa tcggaacgcc 349741 tcgcataaat gagatataga gcttcgccgg ccatcttaac aaagcaagtt tagacattct 349801 ggcgagtgat atgaacaggc cgatcacagt tcccgcaaac atgcttacaa aagagatgag 349861 cagtgtataa ccaatgcctt ttatgacata agggaacgat tcaatggcca gcttcgtgtt 349921 gaaaatatat tcccactgaa tgctattgat catggcgtcc gattacaaat caacgtcctg 349981 aacgtcggca tcaatttttt ttgatacatc tgctttattg aagaattgtt tcgacagttt 350041 agtcaaagag ccatccttgc tcatctcttt caatgcttcg ttcatctttt tctgaagtgc 350101 cgcattgctt tttttcatga caagggcctg tttgttcggc atgtacttga tgtcaggatg 350161 aattgtaatg ttgagatccg ggaatgccgc gagcgcaagt gtctgcaggt aatagtcgtt 350221 taaaatgacg tcagtgcgtc cgttggcaac atcttttaaa tattgctcat tcgtcgcatt 350281 atcataaatc acttctttgg cgccgtattt tctcgcgacc tccatgtaga cggttgtagc 350341 cgcgccagcc gctttcttcc cttttaaatc cttgagcgtt ttaatccctg ataaatcgtc 350401 ttttcggaca attgccgtgc cgtatgaata tttatatgga gtggaaaatg cgaacttctc 350461 ctcacggtcc ttcgtcacat cgatgtcatt cgcggctgcg tcaacctgtc cgctgttcac 350521 cgctgtcagc atcccgtcaa tgcccatctc cttgaactca accttcagcc ccaagcgttt 350581 tgccgcttca cgaacaactt caacctcgta gcccgtcagc ttatcagagc cagagtcagt 350641 atcgtgataa gaagtgggat agagcgtacc tgatgtagcg actacgattt tccctttatc 350701 cttaatctgc tcccagcctg tatccttgga atcggcttca tttttgccgg aacaggctgc 350761 caatataaga aagaaagcca ttgtgaaact gaatataacg gctttggaat gcatgaatga 350821 tttcacctat agttccccca atctgttaat caactaaaaa gatagcattg aacataaggg 350881 gttgcaatat gttgatcgcg ttttcaaaaa gttcgaattg tgtatacaaa aagcatgggt 350941 gggtgtttaa aagcgtctat gaagggaaga ggtgatgaaa aaaggaattg tccaaggatg 351001 aatgccagac gtaccaagga aacgcatgtg aaagtgaagg atgcagcaga cccgtcactc 351061 atctatgcca ataccggaag aaatggtcaa gaggcatgaa accgatcttc agaataaatt 351121 taagtcttgc tgatgcccct aaggcatatg atatattcga tgagaaagaa aatggaaaca 351181 tttaaaccat aatggggagt caaatgaata tttacaaacc agccggattt tggatcagac 351241 ttggagctgc attgttagac tacattatag tctccgtgcc gcttttgctg atctattggc 351301 tgattacagg aaaagaccca aacgacagca tgttcatcag tttggttgtt ctgctgtatt 351361 ctattttgct gccgatgttt tggcgcggtt atcttatcgg aaaaaggatc tgcggaatca 351421 gaatcgtaaa aaaagacgga tcacaggtca gtctgttaac aatgttttta cgggttattg 351481 tagccggcct ggtttactgt ataaccttcg gactcggctt gatcgccagc ctgattctga 351541 ttgccgtacg agaagacaaa cggaccctgc atgatttaat cgcgggaaca tatgtcactt 351601 atgcgacacc aggtgaagag gaacttaatg ctgacgaaga gattagaaag agcgaataat 351661 ggttcgctct ttttattttt atgcataaaa aatacaaggc agcaaaacat atgaaaaata 351721 ggattggagg aataaaatgg atgaaacgaa taaccatcaa cattatcaca atgttcattg 351781 cagcggctgt catttctctg accggtacag ctgaggccgc tgaaaaacag cagcagtctc 351841 ccgcaaatgt tacactgaca gatcagcaaa agaaagagat tgaacaactg gaagcagaga 351901 ttcttaaaaa gcgcaaagac gtgatctcaa agtatgtaca atacggtatc ctgcctaaag 351961 aaagaggaga acacatcaaa aatcacttgg acaaacactt tgaaatgatg aaacaaaacg 352021 gctttgttcc aaagcaccat cctcatccgc ataaatttga aaaaagacat taagatttta 352081 agcatccaat gggaattggg tgcttttgcg ttatttacag gtaggcaata ttagctgagc 352141 tgttccgcga ctaacatcga gttgatatga aacgcgtttc atagcctatg ataggtttat 352201 caaataattc aggagtgata aacactatga tccaccagca tccagaatct tttccgaaac 352261 attttttgtg gggctctgct tctgcagcgt accagattga aggcgcttgg aatgaagatg 352321 gcaaaggccc ttctgtttgg gatgtgttta cgaaaatacc gggcaaaacg tttaaaggaa 352381 ccaatggcga gattgcggtt gaccattatc accgatttaa agaagatgtc gctctgatgg 352441 ctgagatggg gttaaaagca tatcgatttt ccgtcagctg gccacgggtt tttccaaaag 352501 gaaaaggaga gatcaatgaa gcaggtctag cgttttacga tagtctgatt gatgaattgc 352561 tttctcatca catcgagccg gttctgactt tatatcactg ggatttgcct caagcgctta 352621 tggacgaata cggcgggttt gaatccagaa acatcataga ggattttaat cactactgta 352681 ttactcttta taaacgtttt ggagacaggg tgaaatattg ggttacgtta aacgaacaga 352741 actacaattt taatcacgga tttattacag ccatgcatcc gcctggagtg aaagacagaa 352801 aacgatttta cgaagcaaac catattgcgt ttctggctaa tgcaaaagcc atcgaatcat 352861 ttagagaata tgtgcctgaa ggcaaaatag gtcctagctt tgcttattct ccggcttacc 352921 ctttatcaag tcatccagag gatatactgg catttgaaaa cgccgaagaa tttacgaaca 352981 attggtggct tgacatgtat tgctggggaa cctacccgca aattccattc cgctgcttgg 353041 aaaaacaggg atgggcgccg acaattgaag caggagatat ggacctgctc gccaaaggga 353101 agcctgattt tgtaggtgtc aattattatc agacgatcac ctatgaacga aatccgcttg 353161 atggtgtgtc agaagggaaa atgaatacga caggccaaaa gggaaccaat caggagacgg 353221 ggatacccgg agtgttcaaa acgaaaaaaa atccgcatct gacaacgagc aactgggatt 353281 ggacaattga cccaattggg ctgcgtatcg gtcttcgccg aattacaagc cgctatcagc 353341 ttccagtgtt tataacagag aacggtttgg gtgaatttga taaagttgag gacggcactg 353401 tacaggatga ttatcgaatt gattatttgc gttcgcatct tgagcaatgc agacaagcca 353461 tcagtgacgg tgtcgattta atcggctatt gcagctggtc gtttactgat ctgttaagct 353521 ggctgaacgg ctaccaaaaa agatacggat ttgtatatgt caatcgtgat gaagaaagca 353581 catccgattt aaaacgcttg aagaaaaaaa gcttttattg gtatcaagat gtcatcaaga 353641 caaacggaga aagtttataa agagtccctg agagttattc tctcaggggt ttttcattac 353701 acagaaacag catcaataat ataagtgtcg gcgtgcaaat ctgacatttc agccggcaca 353761 gtccagcatg tcaattgata gtctccttta ggcagatcaa aggacagtct tttagacatg 353821 atgctttcaa tatgaattcc gttttctgtg acatgaaaag gaacagtcac ttttttttcg 353881 taggagttta ctgtttctga actgttcagg cgaaaaagaa taaaggcctt tgtatttcgc 353941 tgtgcctcaa aggaaatggc tccgtctgcc gcagcatatc ctttttcaat cgcttcgtca 354001 gtccaatcca ttacaggagg tgtagaatcc ttttgaaata cagtaaattg atgatatgaa 354061 atcgaaagtt cttgcggctt ccatgatttg atcaatgtgc tgttcctcct ctatgtactg 354121 tttactgaat tgtgaataaa acctttgtgc cgtctgggta atcggtaagc cgatgcccga 354181 cccaagagcc tgctccgcgg ttgtcagcgg gagaaatgta ttctacagaa gctccctcac 354241 cgccttcttt gcacatggcc attggccatt catctctgtc ataccccttt ttggaaggta 354301 cgtcctttaa tgattgctcg cggcgttctt cagctccgtc tctgtcaata gtgcacacct 354361 ctgagtgccc ctcatttatc gcatccttaa tatgcttggc agtttcggga taccggtcag 354421 atgggaaggc cattgtttca tcatattctt tcgtttgaga cgttttttga tcagctgaga 354481 aaaagtctcc ttttatcagg ccgacagctg cagctgctat gatgacgatg acgagaagta 354541 tcgtttttat gatgtccgtc gtgatgttca cctcccgctt ttaaaactga cacaagagta 354601 atccagaaag catttggtgt aaaggtttaa attttatgtt ttacgatcag tttattgcag 354661 aaatcgtaat tttagcagat cgaaatattt gttttcagca aaatacgatt gccaatttac 354721 aataatgata gtaagtcatc agccgttttc ggcttgatta atcattttaa attggcttat 354781 gataccggta agctcctcag ctaattgaga aagtgtttca gaagctgcgg taatctcctc 354841 cattgcagca aattgctcct ctgttaatgc agccgcttgc cgggtatttt tagtagattc 354901 tttaatgtcg gccgtattgg ctgcaaagga atcatttatt tgatgtgcac tggctgaaat 354961 gtttgttaca gatgctgata aatcactaat ctcggcgctg atttcacctg ttgcagctgc 355021 aatttcctta aatgcatctc tggtgcgctg gatcatggtg actccttctg cagcttctgt 355081 tttcacatgc tcaacagatc ttgcagaccg gttcatatcc ttttgtattt ctatgatcag 355141 ttttgaaatc tgccccgcag actgttgaga ctcttctgct aatttccgta cttcatcagc 355201 aacaacagca aagccttttc cttgttcacc ggctctggca gcttcaatcg ctgcattcag 355261 cgcaagcagg tttgtctgat cagcaatttg ggtgatgacc gataaaattt gctcaatttg 355321 tttagagcgg ccgtctaact ggtgtatgat ttctccgctt ttctgaattg actggtgaat 355381 cgcatccatt tgcgcctgta catttgcaat ttccttttgt ccaatgtctg cttttgattg 355441 agcgagctgc cctttgtcag cgatagcggc agtatttgca gaaatatccc ggatgtctgc 355501 tgaagcttgt tttaatgagc tttcactatt ttcaattcgg gtgatctgat cttgggctcc 355561 atttgcaatc tgctgtacag cttctgtgat tttttctgaa gcttgatttg tttcctctgc 355621 tccggctgag agctgctgag aggctgacgc aagctgaagg gctgattgtt gtacggtttg 355681 tatggtatcg ttcagcttca ttctcatctt attataatag acgcttagtt ctgaaagctc 355741 gtcaccggtt ttgtctgaca cctctattgt catatctccg tttccggcac tttcaaaggc 355801 gctttttaaa gcgttcagcc gcttgttgat ttttctggtg aaaaccaaga caaggatgac 355861 tgataccata atgacgataa caagaacgat agcgaattga gtgaaaagtg attgtgtaag 355921 tgatgctaaa atactttgat tagctccggt atacagcatg ccgatgatgt tcccattttg 355981 atcttttaac ggcatgtatg cagtctgata agaagaacct gctacatctg cttgtccgta 356041 aaaacgcttt cctttcttta aaacagcggc aataacttca gaagaagcct gggtgccgac 356101 ggctctttcg ccatttttca tgacattggt tgcaacacga gtatcgcctt ggaaaatggt 356161 aatggtatca cctgtctttt caccaagcag atcaacaata tcttcatttc cattgatttg 356221 tgtttgccct ttatagagct tattgttttt cacctgccag tcgcctgaca tgacatcatc 356281 aatataagtg ctgcttaaag cgagatcacc tttcgctttt tcagttgcca tttgtttcat 356341 gctttctgta atttccttaa gcatcacagt gccaactgat gccgaaaaca aaagaatcac 356401 cacgaaaacg aggcaaagaa ttttagttcc tagcttcatc ttaaatcgtt ttatcaacat 356461 aattcctccc tttacgattt gcaggtcata ttacttatcg ggtttttggg tttaaagttt 356521 tattttagaa aaaataaaac cggcctgatc ttcaggccgg ttgtgtgatg ctattcaagg 356581 tttgcgtggt gagtgaacat agtttcagaa tcgagacctt ttttctccat gagttttaaa 356641 atcactgcat catagaagag cagcaaagtt tgttcaaata atgatcccat tggctgaatg 356701 gttttatagc ttccgttaga ctggtcttta ggggaaccag gcattctgat gatgaggtcc 356761 gcttgttttc cgatgcttga ttccggattg atggttaaag cggcaacaat tccgtgtaag 356821 ctttttgctt ttgctgcggt atgaatcaag ctctttgtct cgcctgatcc tgagccgata 356881 ataactagat ctccttcggc gagcggcgga gtgagaatct cacctactat atgggcgttg 356941 aagcccatgt gcatcagtct catcgcgaag gattttgcca tcaggccaga ccgccccgca 357001 cccgcggtga aaatttggtg ggatgaaaga atgtgatcgg caagctggtc agcttcttca 357061 ttagaaatat aagctgctga attgtgtaac tcattgagaa tttccgctac gtattcagtc 357121 gttttcatcg gagttatcct tggacaatca gctgcttcat ttttgaagct gtttccgcct 357181 tatcagctgc gcttgtaatt ccgcccccga caatgacaag gtcaggcttt tgctggatca 357241 cttctggcag tgtatcaagt ttgatgccgc ccgcgattgc ggtttttgcg ttttttacgg 357301 tatttttgat tgtcgttaat tcttcgaaag agtttttgcc ctctgcttga agatcatagc 357361 cagtgtggac gcagatgtag tcaacaccga gtgcgtcaat ttctttcgca cgggattcga 357421 tatctttcac gttaatcatg tccactaaga ttttcttctt ttgttttttg gcttcttcta 357481 ctgcgccttt aatcgttgca tcgtctgtag cccctaaaac ggtgatgatg tcagcgcctg 357541 cttccgacgc tttcataatt tcgtagcctc cggcatccat gattttcagg tctgcaagaa 357601 ccttcaattg aggaaatgct tcttttattt ctttaacggc tcttaggcct tcattgatga 357661 cgaccggtgt tccgatttca actacgtcga tgtattgttc tacctctttg acaagctcaa 357721 tggcttccgg gatgttgacg aggtctaatg caagctgtaa ttccattgtt gatccactcc 357781 ctttttcgaa ttattgttca ttctataggt tccttctttt gttgagaagt aggcactttg 357841 aagtcaacaa gttacttgga ggatactgtg aggagagaca atcagatttc tttcgcttga 357901 ttttatgagt gagtataatg aaaaaagagt ctgcaaaaaa gtaagtaagt gatgatacgt 357961 atctaacata caaaaaggtt actaaggggg gggattctat tgagccggat ggacgacaaa 358021 aggtttaatt gtgagaagga attaacgctt gcagtgattg gcggtaaatg gaaaatgctc 358081 attttatggc atttaggaaa agaaggcaca aaacggttca atgaattaaa aacattgatt 358141 cctgatatta cgcagaagat cctcgtgaat cagctgagag agcttgagca ggatatgatt 358201 gttcacaggg aagtgtatcc agttgtcccg ccgaaggttg aatattctct gaccccgcac 358261 ggagaaagcc tcatgcctat tcttgaagcc atgtatgagt gggggaaagg ctatatggaa 358321 ttgattgata tcgacaaaaa tgtcatgaaa gaatcgttgt aagacgctct tcgcaagggt 358381 gtcttttttt gccttttttt cggtttttgc gcggtacaca tagtcatgta aagattgtaa 358441 attgcattca gcaataaaaa aagattgaac gcagcagttt ggtttaaaaa tttttatttt 358501 tctgtaaata atgtttagtg gaaatgattg cggcatcccg caaaaaatat tgctgtaaat 358561 aaactggaat ctttcggcat cccgcatgaa acttttcacc catttttcgg tgataaaaac 358621 atttttttca tttaaactga acggtagaaa gataaaaaat attgaaaaca atgaataaat 358681 agccaaaatt ggtttcttat tagggtgggg tcttgcggtc tttatccgct tatgttaaac 358741 gccgcaatgc tgactgacgg cagcctgctt taatagcggc catctgtttt ttgattggaa 358801 gcactgcttt ttaagtgtag tactttgggc tatttcggct gttagttcat aagaattaaa 358861 agctgatatg gataagaaag agaaaatgcg ttgcacatgt tcactgctta taaagattag 358921 gggaggtatg acaatatgga aataactttt taccctttaa cggatgcaca aaaacgaatt 358981 tggtacacag aaaaatttta tcctcacacg agcatttcaa atcttgcggg gattggtaag 359041 ctggtttcag ctgatgcgat tgattatgtg cttgttgagc aggcgattca agagtttatt 359101 cgcagaaatg acgccatgcg ccttcggttg cggctagatg aaaacgggga gcctgttcaa 359161 tatattagcg agtatcggcc tgttgatata aaacatactg acactactga agatccgaat 359221 gcgatagagt ttatttcaca atggagccgg gaggaaacga agaaaccttt gccgctatac 359281 gattgtgatt tgttccgttt ttccttgttc accataaagg aaaatgaagt gtggttttac 359341 gcaaatgttc atcacgtgat ttctgatggt atctccatga atattctcgg gaatgcgatc 359401 atgcacattt atttagaatt agccagcggc tcagagacaa aagaaggaat ctcgcattca 359461 tttatcgatc atgttttatc tgaacaggaa tatgctcaat cgaagcggtt tgaaaaggac 359521 aaggcgtttt ggaacaaaca atttgaatcg gtgcctgaac ttgtttcctt gaaacggaat 359581 gcatccgcag ggggaagttt agatgctgag aggttctcta aagatgtgcc tgaagcgctt 359641 catcagcaga ttctgtcgtt ttgtgaggcg aataaagtca gtgttctttc ggtatttcaa 359701 tcgctgctcg ccgcctattt gtacagggtc agcggccaga atgatgttgt gacgggaaca 359761 tttatgggca accggacaaa tgcgaaagag aagcagatgc ttggcatgtt tgtttctacg 359821 gttccgcttc ggacaaacat tgacggcggg caggcgtttt cagaatttgt caaagaccgg 359881 atgaaggatc tgatgaagac acttcgccac caaaagtatc cgtataatct cctaatcaac 359941 gatttgcgtg aaacaaagag ctctctgacc aagctgttca cggtttctct tgaatatcaa 360001 gtgatgcagt ggcagaaaga agaggatctt gcctttttga ctgagccgat tttcagcggc 360061 agcggattaa atgatgtctc aattcatgta aaggatcgat gggatactgg gaaactcacc 360121 atagattttg attaccgcac tgatttattt tcacgtgaag aaatcaacat gatttgtgag 360181 cgcatgatta ccatgctgga gaacgcgtta acgcatccag aacatacaat tgatgaatta 360241 acactgattt ctgatgcgga gaaagagaag ctgcttgcga gggccggcgg taaatctgtg 360301 agctaccgta aggacatgac gataccagag ctgttccaag aaaaggctga actgctttct 360361 gatcatccag cggttgtatt tgaagatcgc acattgtcct atcgaacgtt acatgagcaa 360421 tctgcacgca tcgccaatgt gctgaaacag aaaggggttg gcccggacag tcctgtcgcg 360481 gttttgattg aacgctctga acggatgatt acagctatca tgggaatttt aaaagccggc 360541 ggagcctatg tgccgattga tccgggtttt cctgctgagc gcattcaata tattttggag 360601 gactgcgggg cggatttcat cctgactgaa tcgaaggttg cggcgcctga agccgatgct 360661 gagctgattg acttagatca ggcgattgag gaaggtgcag aagaaagcct gaatgcagat 360721 gtgaacgctc ggaaccttgc ctacattatt tacacatcgg gaacaaccgg acgcccgaaa 360781 ggcgttatga tcgagcatcg ccaggttcat catttggttg aatctctgca gcagacgatt 360841 tatcaaagcg gcagccaaac cctgcggatg gcattgcttg cgccgttcca ctttgatgcg 360901 tcagtgaagc agatcttcgc gtcgcttctt ttgggccaaa ccctttatat cgtaccgaag 360961 aaaacagtga cgaacggggc cgcccttact gcatattatc ggaagaacag cattgaggcg 361021 acggacggaa caccggctca tttgcaaatg ctggcagcag caggcgattt tgaaggccta 361081 aaactgaagc acatgctgat cggaggagaa ggcctgtcat ctgttgttgc ggacaagctg 361141 ctgaagctgt ttaaagaagc cggcacagcg ccgcgtttga ctaatgtgta cgggccgact 361201 gaaacgtgcg ttgacgcgtc tgttcatccg gttatccctg agaatgcagt tcaatcagcg 361261 tatgtgccga tcgggaaagc gctggggaat aaccgcttat atattttgga tcaaaaaggc 361321 cggctgcagc ctgaaggcgt ggcgggtgag ctttatatcg cgggagacgg tgtgggccga 361381 ggctatttac atttgcctga attaacggaa gagaagtttt tacaagatcc attcgtgccg 361441 ggcgatcgca tgtaccggac cggggacgtg gtgcgctggc ttccagatgg aacaatcgaa 361501 tatttaggca gagaggatga ccaggtcaaa gtccgcggat accggattga gcttggggaa 361561 attgaagccg tgattcagca ggcgccagac gttgcaaaag ccgttgtttt ggcacgccct 361621 gacgaacagg gaaatcttga ggtttgcgca tatgttgtgc agaagcctgg aagcgaattt 361681 gcgccagccg gtttgaggga gcatgcggcc agacagcttc ctgactatat ggtgccggct 361741 tactttacag aagtgacaga aattccgctt acaccaagcg gcaaagtcga ccgccgcaag 361801 ctgtttgcac tagaggtgaa ggctgtcagc ggcactgcct atacagcgcc gcgaaatgag 361861 actgaaaaag caatcgcagc catttggcag gacgtgctga acgttgagaa ggcggggatc 361921 tttgacaatt tctttgaaac tggcggacat tcattaaaag ccatgaccct tttaacaaag 361981 attcataagg aaacaggcat tgagattccg cttcaatttt tgtttgagca tccgacgatt 362041 acggctcttg cagaggaagc tgatcacaga gaaagcaaag cttttgcggt gattgaacct 362101 gctgaaaaac aggagcatta cccgctttca ttggcacagc agcgaacata tatcgtcagc 362161 cagttcgagg atgcgggagt cggctataac atgccagcag cagcaattct ggaagggcct 362221 ttagatattc aaaagctgga gcgcgcattt cagggattaa tccgacgcca cgagtcattg 362281 agaacatcat ttgttcttga aaacagcacg ccgagacaga aaattcacga tagcgttgat 362341 ttcaacatcg aaatgattga aagaggcggc cgctcagatg aggcaattat ggcttcattc 362401 gttcggacat ttgatttggc gaaagctccg ctgttcagaa tcggtttgct ggggcttgaa 362461 gagaaccgtc atatgctgct gtttgacatg caccatttga tttctgacgg tgtatccatt 362521 ggcattatgc tggaggagtt agcacgcatt tataaaggcg aacagcttcc tgatcttcgt 362581 ctccagtata aggactacgc tgtatggcaa agcagacagg ctgctgaagg gtacaagaag 362641 gaccaggctt attggaagga agtctttgca ggcgagctcc cggtgcttca gcttctgtcc 362701 gattacccaa gaccacctgt tcaaagcttt gaaggggatc gggtgtcaat caagctggat 362761 gcgggggtaa aggatcgcct caatcgtttg gctgaacaaa acggcgccac tttatatatg 362821 gtgatgcttt ccgcttacta tacgcttttg tcaaagtata cggggcagga tgacatcatt 362881 gtcgggacac cgtcagcggg cagaaatcac tccgatacag agggcattat cgggatgttc 362941 gtcaatacgc ttgcgattcg cagtgaggtg aagcagaatg agacgtttac ccaattgatc 363001 tcgcgtgtcc gcaaacgggt gctggatgcc ttttctcatc aggactatcc gtttgagtgg 363061 cttgttgaag atttgaacat cccgcgtgat gttagcaggc atccgctgtt tgacacgatg 363121 ttcagccttc aaaacgcgac agagggcatt ccggctgtcg gcgatctttc cttgtctgtt 363181 caagagacca atttcaagat tgccaaattt gatttgacgg tgcaggcgag agaaaccgat 363241 gaaggcattg agattgatgt ggattacagc acaaagctgt ttaaacaaag cacggcagac 363301 aggctgctta cgcattttgc gcgtttgctt gaagatgctg cggctgatcc agagaagccg 363361 atttctgagt ataagcttct ttctgaagag gaggctgctt cgcaaattca gcagtttaac 363421 ccgggcagaa caccttatcc gaaagataaa acaattgttc agctgtttga ggagcaagcg 363481 gcgaatacgc cagaccacac tgcgcttcaa tatgaaggcg aatcactcac ttatcgtgaa 363541 ctgaatgaac gggccaatcg tttagcccgc ggcattcttt ctcttggagc tggcgaaggc 363601 agaactgcgg ctgtcttatg cgagcggtca atggatatga ttgtgtcgat cttggcagta 363661 ttaaaatcag gttcggctta tgttccgatc gatccggaac atccgattca gcggatgcag 363721 catttcttcc gtgacagcgg agcaaaggtg cttctcactc agaggaaatt aaaggctttg 363781 gcggaagaag cggaatttaa gggcgttatc gtgctagccg atgaggaaga aagctatcat 363841 gccgatgcgc gaaatctcgc actgcctctt gattctgcag caatggccaa cctgacgtat 363901 acttccggaa cgactggaac acctaagggg aatatcgtga cacatgccaa tattctccgc 363961 acggtgaagg aaacgaatta tctcagcatt acagaacagg atacgattct cggtctttcc 364021 aattacgtgt ttgacgcgtt tatgttcgat atgttcggct ctttgttaaa cggagccaag 364081 ctggtgctga taccgaagga aaccgttttg gacatggctc gcctgtcccg cgtcattgaa 364141 cgggagaaca tcagcattct catgattaca accgctttgt tccacttgct tgtggacttg 364201 aatccggcat gcttgtcaac gcttcgcaag attatgtttg gcggggaacg ggcttcggtt 364261 gagcatgtca gaaaagcttt gcaaacggtt ggaaagggca agctccttca tatgtatgga 364321 ccgtctgaaa gcacggtttt cgcgacgtat catccggttg atgaattgga ggagcacacg 364381 ctgtctgttc cgattggaaa accggtcagc aatacggaag tatacattct tgaccgtacg 364441 ggacacgtgc agcctgccgg gattgccgga gagctttgcg tcagcggcga aggactcgtg 364501 aaaggctatt acaaccgtcc agaactgact gaggagaaat ttgttcccca tccgtttaca 364561 tccggcgaac gcatgtataa aacgggagac cttgcgagat ggctgccgaa tggcgacatc 364621 gaatttatcg ggcgaatcga ccatcaggtg aagattcgcg gacagcgcat cgagcttgga 364681 gaaatcgaac atcagctgca aacccatgat cgtgttcagg aaagtgttgt gcttgccgtt 364741 gatcaaggag cgggagataa actgttgtgt gcttactatg tcggagaagg agacatctca 364801 tcacaagaga tgagagagca tgctgcgaag gacttgccgg catatatggt tcctgcggtg 364861 tttatccaaa tggacgagct gccgctgaca gggaacggaa aaattgaccg gagagcgctg 364921 ccgattcctg atgccaacgt ttcaagaggt gtttcatatg ttgcgccacg caatggaacg 364981 gaacaaaaag tcgcggacat ttgggcacag gtacttcagg cagaacaagt cggcgcttat 365041 gaccacttct ttgacattgg cggacattca ttagcaggca tgaagatgct tgccttggtt 365101 catcaggaac tgggcgttga gctgtcactc aaggatctct tccagtcacc gacggttgag 365161 ggcttggcac aggtgattgc ctctgctgaa aaagggacag ccgcaagtat cagcccggca 365221 gagaaacaag atacgtatcc tgtttcttca ccgcaaaaac ggatgtacgt gcttcagcag 365281 cttgaggatg cgcaaacgag ctataacatg ccggcggttc tgcgcctgac aggtgagctt 365341 gatgttgaaa ggcttaacag cgtcatgcag cagttaatgc agcgtcatga agccttgaga 365401 accacgtttg aaataaaaga tggagaaacg gtgcagcgga tctgggaaga ggctgagtgc 365461 gagatagcct atttcgaagc cccggaagaa gagacagagc ggatcgtttc tgagtttatt 365521 aagcctttca aaatcgacca acttccactg ttcagaatag ggcttatcaa gcattcagac 365581 actgagcatg tgctgctgtt cgatatgcat catattattt ctgatggtgc atctgtcggt 365641 gtgctgattg aggagctttc aaagctgtac gacggagaaa cccttgagcc gctccgtatt 365701 caatataagg attatgccgt gtggcagcag cagttcattc agtctgagct ttacaagaag 365761 caagaagagc attggctgaa ggagctggac ggagagctgc cggtgctgac gcttccgact 365821 gattacagtc ggcctgccgt tcaaacattt gagggagacc gcattgcatt ttcattagaa 365881 gcaggcaaag ctgatgctct gcgcaggctt gcaaaagaaa cggattccac gctttacatg 365941 gtgcttctgg cttcatacag tgcgttttta tcaaaaatta gcgggcaaga cgatatcatc 366001 gtcggttcac ctgtggccgg acgatctcaa gcggacgtca gccgcgtcat cggaatgttc 366061 gtcaatacat tggcgctgcg cacgtatccg aagggtgaaa agacgtttgc tgactatctt 366121 aacgaagtga aagaaacggc actcagcgct tttgatgcgc aggattaccc acttgaggat 366181 ttgatcggaa atgttcaggt tcagcgtgac acaagcagaa atccgttatt cgatgcagtt 366241 ttttcaatgc aaaatgcgaa tataaaggat ttaacaatga aagggattca gcttgagccg 366301 catccgtttg aacggaaaac agccaagttt gacctcacgc tgacggctga cgaaaccgac 366361 ggagggctta cattcgtact cgaatacaat acagctctgt ttaagcagga aacgattgaa 366421 cgatggaagc aatattggat ggagctttta gatgcagtta ctgggaaccc gaaccagccg 366481 ctttccagcc tgtcactggt caccgagaca gaaaagcaag cgcttcttga ggcatggaag 366541 ggcaaagcgc tgcctgtgcc gacagacaaa acggttcatc agctattcga agagactgcc 366601 cagcgccaca aagaccgccc ggctgtcaca tacaacggcc agtcttggac gtacggcgag 366661 ctgaatgcga aggcaaaccg tctcgcgcgg attctgatgg actgcggcat cagcccggat 366721 gaccgcgtcg gcgttctcac gaagccgtcg cttgaaatgt ccgccgcggt gctcggcgtc 366781 ttgaaagccg gagcggcgtt tgtgccgatt gatcctgact atccggatca gcggattgag 366841 tatattttac aggacagcgg cgcgaagctt ctcttgaaac aggaaggcat ttcagtgccg 366901 gacagctata cgggagatgt cattcttctc gacggaagcc gcacgattct aagcctgccg 366961 cttgatgaaa acgacgagga aaatccagaa accgctgtaa ccgcggagaa cttggcgtac 367021 atgatttaca cgtctggaac gaccggacag ccgaagggtg tcatggtcga gcaccatgcg 367081 cttgtgaacc tgtgcttctg gcaccacgac gcgttcagca tgacagcgga ggaccgcagt 367141 gcgaagtacg cgggctttgg gttcgacgct tccatttggg agatgttccc gacctggacg 367201 atcggtgccg aacttcacgt cattgaggaa gcgatccgcc tcgatatcgt ccgcctgaac 367261 gattattttg aaacgaacgg cgtaacgatc acgttcctgc cgacacagct tgcggaacag 367321 ttcatggagc ttgagaacac atcacttcgc gtattgctta ctggaggaga caagctgaag 367381 cgcgcagtga aaaagccgta cacactcgtc aataactacg ggccgacaga gaatacggtc 367441 gttgccacaa gcgcagaaat ccatccggag gaaggctcgc tttccatcgg aagggccatt 367501 gccaatacga gagtatacat tctcggcgag ggcaatcagg tgcagccgga aggcgtagcc 367561 ggagagcttt gcgtggcggg gcgcggactg gcacgcggct atctgaatcg agaagacgaa 367621 accgcgaagc ggtttgtcgc tgatccgttt gtgccgggtg agcgcatgta ccgcaccggc 367681 gatttggtga aatggacggg cggcggcatc gaatacatcg gccggatcga ccagcaggtc 367741 aaggtccgcg gctaccggat cgagctctca gaaattgaag tccagctcgc ccagctttct 367801 gaggtgcagg atgcggcggt gacagctgtc aaagataaag gcggcaacac agcgatcgcg 367861 gcgtatgtca caccggaatc agctgacata gaagcactga aatcagcact gaaggaaacc 367921 ctgccggatt acatgatccc ggcgttctgg gtgacgctga acgagcttcc ggttacggca 367981 aacggcaaag tggaccgcaa agccttgcct gagccggaca tcgaagcggg aagcggagaa 368041 tacaaagcgc cgacgaccga catggaagag ctgcttgccg gcatctggca ggacgtgctt 368101 ggaatgtctg aagtcggtgt caccgacaat ttcttctcgc ttggcggaga ttccatcaaa 368161 ggaattcaaa tggcgagccg cttgaaccag cacggctgga agctggaaat gaaagatctc 368221 ttccagcacc cgacgatcga agagctcacc cagtacgtag agcgtgccga aggcaaacag 368281 gcagaccaag gcccggtgga gggcgaagtc atcctgacgc cgatccagcg ctggttcttt 368341 gaaaagaact tcacgaacaa gcaccactgg aaccaatctg tgatgcttca cgccaagaag 368401 ggctttgatc ctgaacgggt ggagaaaaca ttgcaggcgc tgatcgagca tcatgacgcg 368461 ctccgcatgg tctatcgtga gggacaggaa gacgtcattc aatacaacag aggtcttgaa 368521 gctgcttcag ctcaattgga ggtcatccag attgagggcc aagctgcaga ttacgaagac 368581 cgaatagaga gagaagcgga gcgtttgcaa agcagcatcg acttgcagga aggcggcttg 368641 ttaaaagcag gcttgttcca agcggaagac ggagatcact tgcttcttgc cattcaccac 368701 ttagtggttg acggcgtgtc gtggcggatt ttactggagg atttcgccgc ggtatataca 368761 cagcttgagc aaggcaatga accggttctc ccgcagaaaa cacattcatt tgcagagtat 368821 gcagagagat tgcaagactt cgcgaactcc aaagcctttt tgaaagaaaa agagtattgg 368881 agacagcttg aagaacaagc tgttgcggca aagcttccga aagaccgcga atctggtgat 368941 cagcgaatga aacatacaaa gacaattgaa ttctcgctga ctgctgaaga gacagaacag 369001 ctcaccacaa aggtgcatga ggcatatcac acagaaatga atgatatttt gctgacggca 369061 ttcggattgg caatgaagga gtggacgggt caagatcgag taagtgttca tttagagggg 369121 catggacgtg aagaaatcat agaagacctg accatttctc gcacagtcgg ctggtttaca 369181 agtatgtacc caatggtgct cgatatgaag catgcggatg atctgggcta ccagctgaag 369241 caaatgaaag aagatatcag acatgtgccg aataagggag tcggatacgg cattctgcgc 369301 tatctgacgg caccggaaca taaagaagat gtggcgttct cgattcagcc ggatgtcagc 369361 ttcaactatt taggtcagtt tgacgaaatg tcggatgcag gtttgtttac gagatcagag 369421 ctgccatcag gacagtcatt aagccctgaa acagaaaaac cgaatgcgct ggatgttgtc 369481 ggatatatcg aaaacggaaa actgacgatg tcactggcct atcattctct tgaatttcat 369541 gaaaaaacag tacaaacatt cagtgacagc tttaaagcgc atcttctcag aatcattgaa 369601 cattgcctat ctcaagatgg tacggaactg accccgagtg atcttggtga cgacgatttg 369661 acgctggatg agctggataa attaatggaa attttctaat agaggtggca tatgagcaaa 369721 aaatcgattc aaaaggtgta cgcactgaca ccaatgcagg agggaatgct gtatcatgcg 369781 atgcttgatc cgcattcttc ctcgtacttc acacaattag agcttgggat tcacggcgct 369841 tttgatcttg aaatctttga gaaaagcgtc aatgaactga ttcggtcata cgatattctc 369901 cgtacggtat ttgtgcatca gcagctgcaa aaaccgcgtc aggtcgtgtt agcggaacgc 369961 aaaacaaaag tgcattatga ggatatcagt catgcagacg aaaaccgcca gaaagagcac 370021 attgagcgtt acaaacaaga cgttcagcgc caaggcttta acctggcaaa agacatattg 370081 ttcaaggtag cggttttccg ccttgctgca gatcagctgt atcttgtctg gagcaatcat 370141 catattatga tggacggctg gagcatgggc gtcctcatga aaagcctgtt ccaaaactat 370201 gaagcgctca gagcaggcag gacaccggca aacggtcagg gcaagcctta ttccgattac 370261 atcaagtggc ttggaaaaca ggacaatgaa gaagcggaga gctactggag cgagcgcttg 370321 gcgggttttg aacagccaag cgtgctcccg ggccgcctgc ctgtgaaaaa agacgaatac 370381 gtcaataaag aatattcatt tacatgggac gaaacactgg ttgcccgtat tcagcaaacc 370441 gcaaatctcc atcaagtgac agggcctaac ctatttcagg ccgtttgggg cattgttctc 370501 agcaaataca actttacgga tgatgtgatc ttcggaacgg tcgtctcggg acgaccgtct 370561 gaaatcaacg gaatcgaaac gatggcgggg ctgtttatca acaccattcc agtgcgggtg 370621 aaagttgaac gagatgctgc attcgctgat attttcacag ctgttcagca gcatgcagta 370681 gaggcagagc gttacgatta cgtgccgctc tatgagattc aaaaacgctc agctcttgat 370741 ggcaatctct taaaccatct ggtcgcgttt gaaaattatc cgcttgatca agagcttgaa 370801 aacggcagca tggaagaccg cctcgggttt tcgattaagg tagaaagcgc atttgaacaa 370861 acgagcttcg atttcaacct gattgtgtat ccgggcaaaa cgtggaccgt caaaattaaa 370921 tataacggag ccgcctttga ttccgctttt atcgaacgga cagcggagca ccttacccgc 370981 atgatggaag cagctgtcga tcagccggcc gcttttgtgc gtgagtacgg gcttgtggga 371041 gacgaagagc agcggcaaat tgtcgaggtg tttaacagca cgaaagccga actccctgaa 371101 ggaatggctg ttcaccaagt gtttgaagag caagcgaaac ggacgccggc gagcaccgcc 371161 gtcgtatatg aaggaaccaa gctgacgtac cgcgagctga atgcagcggc taaccgtctg 371221 gcgagaaagc ttgtcgaaca tgggcttcaa aaaggggaaa cagcagcgat tatgaacgac 371281 cgctcagtag aaaccgttgt cggcatgctg gctgttttaa aagcaggcgc cgcatatgtg 371341 ccgcttgatc cagcgcttcc tggggatcgt cttcgtttca tggcagagga cagctccgtt 371401 cgaatggttt tgatcggaaa ttcttataca gggcaggcac atcagctgca agtgccggtt 371461 cttacactgg acataggctt tgaagagagt gaagcggctg acaatctcaa cctgccatcc 371521 gccccgtctg atttggcgta catcatgtac acatccggtt caacgggcaa accgaaaggc 371581 gtcatgatcg aacataaaag cattctgcgc ctcgtcaaaa atgccgggta cgttcctgtt 371641 actgaagaag accgcatggc gcaaacggga gctgtcagct ttgatgccgg aacgtttgag 371701 gtattcggcg cactgctgaa tggcgcagca ctttatccgg tcaaaaaaga gacactgctt 371761 gatgcgaaac aatttgctgc attcctgcgt gagcaaagca tcacaactat gtggctgaca 371821 tcacctttat tcaaccagct tgctgcaaag gatgcgggta tgttcggcac actgcgccat 371881 ttaatcatcg gcggagatgc ccttgtcccg catattgtca gcaaagtaaa acaggcatcg 371941 ccgtcgcttt cattgtggaa cggatacggc ccgacagaaa acacgacgtt ttcaaccagt 372001 tttctgatcg accgcgagta tggcggctct atcccaatcg ggaagccgat cggaaattcc 372061 actgcctata ttatggatga gcagcaatgc ctgcagccaa tcggcgcgcc tggtgagctt 372121 tgcgtaggcg gaatcggtgt agcgcgtggg tatgtcaatc tccctgagct gacggagaag 372181 caatttctgg aagacccgtt cagaccgggt gagagaattt accgcactgg tgacttggca 372241 agatggctgc cggacggcaa tatcgaattt ttaggcagaa tcgacaacca agtgaaggtg 372301 cgcggcttcc gaattgagct tggcgaaatt gaaacaaaac tgaacatggc tgagcatgtg 372361 acagaagccg cggtgatcat acgcaagaac aaagcagacg aaaatgaaat ttgcgcgtac 372421 ttcacggcgg atcgtgaagt ggctgtgagt gagctgagaa aaacactgtc tcagtctttg 372481 cctgactata tggtccctgc ccacctgatt caaatggaca gcctgccgct cacgccaaac 372541 gggaaaatca acaaaaagga actgcctgca ccgcaatcag aagccgtgca gccggaatac 372601 gcagcaccaa aaacagagag tgaaaagaaa ttagcggaga tctgggaagg aatactcggc 372661 gtcaaagcag gcgttaccga taacttcttt atgatcggcg gccattcttt gaaagcgatg 372721 atgatgacgg cgaaaattca agagcatttt cataaggaag ttccgataaa agtgcttttt 372781 gaaaagccga ctattcaaga actggcactg tatttggaag agaacgaaag caaggaggag 372841 cagacgtttg aaccgatcag gcaagcatct tatcagcagc attatcctgt atccccggcc 372901 cagcggagaa tgtatatcct caatcagctt ggacaagcaa acacaagcta caacgtcccc 372961 gctgtacttc tgctggaggg agaagtagat aaagaccggc ttgaaaacgc gattcagcaa 373021 ttaatcaacc ggcacgaaat cctccgtaca tcgtttgaca tgatcgacgg agaggttgtg 373081 caaaccgttc ataaaaacat atcgttccag ctggaggctg ccaagggacg ggaagaagac 373141 gcggaagaga taatcaaagc atttgttcag ccgtttgaat taaaccgcgc gccgctcgtc 373201 cgttcgaagc ttgtccagct ggaagaaaaa cgccacctgc tgctcattga tatgcatcat 373261 attattactg acggaagttc aacaggcatt ctaatcggtg atcttgccaa aatatatcaa 373321 ggcgcagatc tggaactgcc acaaattcac tataaagatt acgcagtttg gcacaaagaa 373381 caaactaatt atcaaaaaga tgaggaatac tggctcgatg tctttaaagg cgaactgcca 373441 atactggatc ttcccgcgga tttcgagcgg ccagctgaac ggagctttgc gggagagcgc 373501 gtgatgtttg ggcttgataa gcaaatcacg gctcaaatca aatcgctcat ggcagaaaca 373561 gatacgacaa tgtacatgtt tttgctggcg gcgttcaatg tactcctttc caagtacgcg 373621 tcacaggatg atatcattgt cggctcgccg acagctggca gaacacatcc tgatctgcaa 373681 ggtgtgccgg gtatgtttgt caacacggtg gcactcagaa cggcaccagc gggagataaa 373741 accttcgcgc aattccttga agaggtcaaa acagccagcc ttcaagcatt cgagcaccag 373801 agctatccgc ttgaggagct gattgaaaag cttccgctta caagggatac aagcagaagt 373861 ccgctgttca gcgtgatgtt caacatgcag aatatggaga ttccttcatt aagattagga 373921 gatttgaaga tttcctcgta ttccatgctt catcatgttg cgaaatttga tctttccttg 373981 gaagcggtcg agcgtgaaga ggatatcggc ctaagctttg actatgcgac tgccttgttt 374041 aaggacgaga cgatccgccg ctggagccgc cactttgtca atatcatcaa agcggccgcg 374101 gctaatccga acgttcggct gtctgatgta gatctgcttt catctgcaga aacggctgct 374161 ttgctagaag aaagacatat gactcaaatt accgaagcaa cctttgcagc actttttgaa 374221 aaacaggccc agcaaacacc tgaccattct gcggtgaagg ctggcggaaa tctgttgacc 374281 tatcgcgagc ttgatgaaca ggcgaaccag ctggcgcatc atcttcgtgc ccaaggggca 374341 ggaaatgaag acatcgtcgc gattgttatg gaccggtcag ctgaagtcat ggtatccatt 374401 ctcggtgtca tgaaggcggg ggcagctttc cttccgattg atcctgatac acctgaagaa 374461 cgaatccgtt attcattaga ggacagcgga gcaaaatttg cggtcgtgaa tgaaagaaac 374521 atgacggcta ttgggcaata tgaagggata attgtcagcc ttgatgacgg taaatggaga 374581 aatgaaagca aggagcgccc atcatccatt tccgggtctc gcaatcttgc atacgtcatt 374641 tatacgtccg gtacgaccgg aaagccaaag ggcgtgcaga ttgagcatcg taatctgaca 374701 aactatgtct cttggtttag tgaagaggcg ggcctgacgg aaaatgataa gactgtattg 374761 ctttcatctt acgcatttga ccttggctat acgagcatgt tccctgtact tctgggcggg 374821 ggcgagctcc atatcgtcca gaaggaaacc tatacggcgc cggatgaaat agcgcactat 374881 atcaaggagc atgggatcac ttatatcaag ctgacaccgt ctctgttcca tacaatagtg 374941 aacaccgcca gttttgcaaa agatgcgaac tttgaatcct tgcgcttgat cgtcttggga 375001 ggagaaaaaa tcatcccgac tgatgttatc gccttccgta agatgtatgg acataccgaa 375061 tttatcaatc actacggccc gacagaagca acgatcggcg ccatcgccgg gcgggttgat 375121 ctgtatgagc cggatgcatt tgcgaaacgc ccgacaatcg gacgcccgat tgcgaatgcc 375181 ggtgcgcttg tcttaaatga agcattgaag cttgtgccgc ctggagcgag cggacagctc 375241 tatatcacgg gacaggggct cgcgagaggg tatctcaaca ggcctcagct gacagccgag 375301 agatttgtag aaaatccata ttcgccggga agcctcatgt acaaaaccgg agatgtcgta 375361 cgaagacttt ctgacggtac gcttgcattt atcggccggg ctgatgatca ggtgaaaatc 375421 cgaggctacc gcattgagcc gaaagaaatt gaaacggtca tgctcagcct cagcggaatt 375481 caagaagcgg ttgtactagc ggtttccgag ggcggtcttc aagagctttg cgcgtattat 375541 acgtcggatc aagatattga aaaagcagag ctccggtacc agctttccct aacactgccg 375601 tctcatatga ttcctgcttt ctttgtgcag gttgacgcga ttccgctgac ggcaaacgga 375661 aaaaccgaca gaaacgctct gccgaagcct aacgcggcac aatccggagg caaggccttg 375721 gccgcaccgg agacagcgct tgaagaaagt ttatgccgca tttggcagaa aacgcttggc 375781 atagaagcca tcggcattga tgacaatttt ttcgatttag gcggccattc attaaaaggg 375841 atgatgctga ttgccaacat tcaggcggaa ttggagaaaa gcgtaccgct taaagcactg 375901 ttcgagcagc cgacagttcg ccagctggcg gcttatatgg aggcgtctgc tgtttcaggc 375961 ggccatcaag tactcaaacc ggctgacaag caggatatgt atccattgtc atccgcacag 376021 aaacgaatgt acgtgctcaa tcagcttgac cgccagacga taagctacaa catgccatct 376081 gttcttctaa tggaaggaga gcttgatatt tcgcgcctgc gcgactcact caatcagctt 376141 gtgaaccgtc acgaatcatt gcggacgtca tttatggaag ctaatggtga gcctgttcag 376201 cgcatcattg agaaggcgga ggttgatctt catgtgtttg aagccaaaga agacgaagcg 376261 gaccaaaaga ttaaggaatt tatccggcca ttcgacttaa acgacgcacc gctcattcgc 376321 gcagctttgc ttcgaataga agcgaaaaaa catttgctgc ttttagatat gcatcatatc 376381 atcgcagacg gcgtctcaag aggcatcttt gtaaaagaat tggcgctgct ttacaaagga 376441 gagcagcttc cggagccgac gcttcattat aaagatttcg ccgtttggca aaatgaagct 376501 gagcaaaaag aacggatgaa ggagcatgag gcgtactgga tgtcagttct ttcaggcgag 376561 ctgccagagc ttgatctccc gctcgattat gcccgtccgc ctgtgcaaag ctttaaagga 376621 gatacgatcc gtttccgtac gggaagtgag acggcaaagg cggtagaaaa actgcttgcc 376681 gaaaccggaa cgaccttgca catggtgctc catgctgttt tccacgtctt tttaagcaaa 376741 atttccggac agcgggatat cgtcatcggc tccgttactg ccggccggac gaatgctgat 376801 gttcaggaca tgccgggaat gttcgtcaat acacttgccc tgagaatgga agcgaaagaa 376861 cagcaaacat ttgcggagct tttggagcta gcaaagcaga cgaacctgtc agcccttgag 376921 catcaggagt atccgtttga agatctggtt aatcagcttg atctccctcg ggatatgagc 376981 cgaaacccat tgtttaatgt gatggtgacg acagaaaacc ctgataaaga acagcttaca 377041 ttgcaaaatc tgagcatttc accttatgag gctcatcagg gaacttctaa gtttgatctg 377101 acactgggcg gatttactga tgaaaatggc attggcttgc agctcgaata tgcgacagat 377161 ctgttcgcaa aagaaacagc tgaaaaatgg agcgaatacg ttctgcggct actaaaggct 377221 gttgcggata acccgaacca gccgctttcc agtctgttac tggtcaccga gacagaaaag 377281 caagcgcttc ttgaggcatg gaagggcaaa gcgctgcctg tgccgacaga caaaacggtt 377341 catcagctat tcgaagagac tgtccagcgc cacaaagacc gcccggctgt cacatacaac 377401 ggccaatctt ggacgtacgg cgagctgaac gcgaaggcaa accgcctcgc ccggattctg 377461 atggactgcg gcatcagccc ggatgaccgc gtcggcgttc tcacgaagcc gtcgcttgaa 377521 atgtccgccg cggtgctcgg cgtcttgaaa gccggagcgg cgtttgtgcc gattgatcct 377581 gactacccgg atcagcggat tgagtatatt ttacaggaca gcggcgcgaa gcttctcttg 377641 aaacaggaag gcatttcagt gccggacagc tatacgggag atgtcattct tctcgacgga 377701 agccgcacga ttctaagcct gccgcttgat gaaaacgacg agggaaatcc agaaaccgct 377761 gtaaccgcgg agaacttggc gtacatgatt tacacgtctg gaacgaccgg acagccgaag 377821 ggtgtcatgg tcgagcacca tgcgcttgtg aacctgtgct tctggcacca cgacgcgttc 377881 agcatgacag cggaggaccg cagtgcgaag tacgcgggct tcgggttcga cgcttccatt 377941 tgggagatgt tcccgacctg gacgatcggc gctgaacttc acgtcattga tgaagcgatc 378001 cgcctcgata tcgtccgcct gaacgattat tttgaaacga acggcgtaac gatcacgttc 378061 ctgccgacac agcttgcgga acagttcatg gagcttgaga acacatcact tcgcgtcctc 378121 ttgaccggag gagacaagct gaagcgggca gtgaaaaagc cgtacacact cgtcaacaac 378181 tacgggccga cagaaaatac ggtcgttgcc acaagcgcag aaatccatcc ggaggaaggc 378241 tcgctttcca tcggacgggc cattgccaat acgagagtat acattctcgg cgagggcaat 378301 caggtgcagc cggaaggcgt agccggagag ctttgcgtgg cggggcgcgg actggcacga 378361 ggctatctga atcgagaaga cgaaaccgcg aagcggtttg tcgctgatcc gtttgtgccg 378421 ggtgaacgca tgtaccgcac cggcgacttg gtgaagtggg tgaacggcgg catcgaatac 378481 atcggccgga tcgaccagca ggtcaaggtc cgcggctacc ggatcgagct ctcagaaatt 378541 gaagtccagc tcgcccagct ttctgaggtg caggatgcgg cggtgacagc tgtcaaagat 378601 aaaggcggca atacagcgat cgcggcgtat gtcacaccgg aaacagctga catagaagca 378661 ctaaaatcaa cactaaagga aaccctgccg gattacatga tcccggcgtt ctgggtgacg 378721 ctgaacgagc ttccggttac ggcaaacggc aaagtcgacc gcaaagcctt gcctgagccg 378781 gacatcgaag cgggaagcgg agaatacaaa gcgccgacga ccgacatgga agagctgctt 378841 gccggcatct ggcaggacgt gcttggaatg tctgaagtcg gtgtcaccga caatttcttc 378901 tcgcttggcg gagattccat caaaggaatt caaatggcga gccgcttgaa tcagcacggc 378961 tggaagctgg aaatgaaaga tctcttccag catccgacga tcgaagagct cacccagtac 379021 gtagagcgtg ccgaaggcaa acaggcagac caaggcccgg tggagggcga agtcatcctg 379081 acgccgatcc agcgctggtt ctttgaaaag aacttcacga acaagcacca ctggaaccaa 379141 tcggtgatgc ttcacgccaa aaagggcttt gatcctgaac gggtggagaa aacattgcag 379201 gcgctgatcg agcatcatga cgcgctccgc atggtctacc gcgaggaaaa cggggacatc 379261 gttcaggtgt ataaaccgat cggtgagagc aaggtcagct tcgaaatcgt ggatctgtac 379321 ggctccgatg aagagatgct gagaagccag attaagcttc tcgcgaacaa gctgcaaagc 379381 agtctcgatc tgcgaaacgg gccgctttta aaggcggagc aatatcgcac agaagctggg 379441 gatcacctgc tcattgctgt acaccatctc gtggtcgacg gtgtgtcatg gcggattttg 379501 cttgaagact ttgcttcagg ctacatgcag gctgagaaag aagagagcct tgtcttcccg 379561 caaaaaacaa actccttcaa ggattgggcg gaagaactgg cggcattcag ccaatcagcg 379621 catcttttac agcaggctga atactggtcg caaattgccg ctgaacaggt ttctccttta 379681 cctaaggatt gtgaaacaga gcagcggatc gtcaaggata catcatctgt cctatgtgaa 379741 ttaacggcag aagacactaa gcatctttta acagatgttc atcagccata tggaactgaa 379801 atcaacgata ttcttctcag cgcgctcggt ttgacaatga aagaatggac aaagggggcc 379861 aaaattggca ttaaccttga gggacacggc cgggaggaca ttatcccgaa tgtgaatatc 379921 tccagaacgg tcggctggtt tacggcacaa taccctgttg tgctcgacat atctgacgca 379981 gatgcctcag ctgtgatcaa aacagtcaaa gaaaacctgc gccgcattcc ggacaaaggt 380041 gttggctacg gcattcttcg ttatttcaca gaaacagcgg aaacaaaggg cttcacaccg 380101 gagatcagct tcaactattt gggccaattc gacagtgaag tcaaaaccga tttctttgaa 380161 ccgtccgctt tcgatatggg gcgccaagta agcggagaat cagaggcgct gtacgcatta 380221 agcttcagcg gcatgatcag aaacggccgg tttgtgcttt cctgctccta caatgagaag 380281 gagtttgaaa gagctacagt cgaggagcaa atggaacggt ttaaagaaaa cctcctgatg 380341 ctaatccgcc attgcacgga aaaagaagac aaggaattca caccaagcga cttcagcgcc 380401 gaagaccttg aaatggacga gatgggagat atctttgaca tgcttgagga gaatttaaaa 380461 taaaacgcaa gggaattaca gaaggcggga gcgaaacata tgagtcaatt tagcaaggat 380521 caggttcaag atatgtatta cctatcgccg atgcaggaag ggatgctttt tcatgccatc 380581 ctgaatcccg gccaaagctt ttaccttgaa caaatcacga tgaaagtaaa aggcagcttg 380641 aatatcaaat gtcttgaaga aagcatgaat gtgatcatgg accggtacga tgtatttcgt 380701 accgtgttca ttcacgaaaa agtaaaaagg cctgtccaag tcgtattgaa aaaacggcag 380761 ttccatatag aagaaatcga tctgacacac ttaacgggca gcgagcaaac agccaaaatc 380821 aatgagtaca aagaacagga taagatcagg ggttttgatt tgacgcggga tattccgatg 380881 cgggcagcca ttttcaagaa agctgaagaa agctttgaat gggtgtggag ctaccaccac 380941 attattttgg acggatggtg cttcggcatc gtcgtacagg atctatttaa ggtatacaat 381001 gctctgcgcg aacaaaagcc gtacagcctg ccgcccgtca aaccgtataa agactacatc 381061 aagtggcttg aaaagcagga taaacaagca tcactgcgtt actggcgcga atatttagag 381121 ggctttgaag gacaaacgac gtttgcggag caaagaaaga aacaaaagga cggctatgag 381181 ccgaaagagc tgctcttttc actgtcggag gcggaaacaa aggcctttac cgagcttgca 381241 aaatcgcagc ataccacttt gagtacggcg ctgcaggcag tctggagcgt attgatcagc 381301 cgctatcagc agtctggcga tttggccttc ggtacagttg tttcagggcg tcccgcggaa 381361 atcaaaggcg ttgaacatat ggtcgggctg tttatcaacg ttgtcccgag acgtgtgaag 381421 ctgtctgagg gtatcacatt taacggcttg ctcaagcggc tgcaggagca atcgctgcag 381481 tccgagccgc atcaatatgt gccgctttat gacatccaaa gccaggccga tcagccgaaa 381541 ctgattgacc acatcattgt ttttgagaac tatccgcttc aggatgcgaa aaatgaagaa 381601 agcagtgaaa acggctttga tatggtggat gttcatgttt ttgagaagtc gaattatgat 381661 ctcaacctga tggcttcccc gggagatgag atgctgatta agcttgccta taatgagaat 381721 gtgtttgatg aggcgtttat cctgcgcttg aaatctcagc ttcttacagc aattcagcag 381781 ctcatccaga atcctgatca gcctgtcagc acgatcaacc tcgttgacga cagggagaga 381841 gaatttttgc taaccggctt aaacccgccg gctcaagctc atgaaacaaa gcctctgacg 381901 tattggttca aggaagcagt gaacgccaat ccggatgcac cggcgcttac gtattccggc 381961 cagaccctgt cttatcgcga attagatgag gaagcgaacc gcattgcacg ccggctgcaa 382021 aaacacggtg cgggcaaagg ctctgttgta gcgctgtaca cgaagcgctc acttgaactg 382081 gtgatcggca ttctcggtgt attaaaggcg ggagcagcct atctgccggt tgatccgaag 382141 ctgccagagg accgaatctc gtatatgctg gctgacagtg cggcagcctg tcttctgacg 382201 catcaggaga tgaaagaaca agcggctgag ctgccgtata caggcacaac gctcttcatt 382261 gatgatcaaa cacggtttga agaacaggca agcgatcctg caaccgcgat tgatcctaat 382321 gatccggcat atatcatgta cacgtccggc acaaccggaa agccaaaggg caatatcacc 382381 actcatgcca atattcaagg attggtcaag catgtagact acatggcatt ttctgatcag 382441 gatacgttct tgtctgtttc gaattacgcc tttgatgcat ttacctttga tttctatgct 382501 tctatgctga atgcggcacg gctcattatc gcagatgaac atacgctgct tgatacagaa 382561 cggctcacag atctgatcct gcaagagaat gtcaatgtca tgtttgcgac aaccgcacta 382621 tttaatcttc tcacagatgc gggagaggat tggatgaagg ggcttcgctg tatattattc 382681 ggcggagagc gcgcgtcagt gcctcatgtc agaaaagcgc tgcggatcat ggggccgggc 382741 aagctgatta actgctacgg gccgactgag ggaacagtgt ttgcgacagc tcacgtcgtg 382801 catgatctgc cggattccat ctcctcattg ccgatcggaa agccgatcag caatgccagt 382861 gtttatattc tgaatgagca aagccagctc cagccattcg gggcggtcgg tgaactgtgc 382921 atcagcggaa tgggcgtgtc aaaagggtat gtaaatcgtg ctgacctcac gaaggaaaag 382981 tttatcgaga acccgttcaa gccgggagaa acgctttacc gtacagggga tttagcgcgc 383041 tggctgccgg atggaacgat tgaatacgcc ggccgtattg acgaccaggt caaaatacgc 383101 ggacaccgga ttgagcttga agaaatcgaa aagcagctgc aggaataccc aggtgtgaaa 383161 gatgcggtcg ttgtggcgga ccgccatgag tctggcgatg catcaatcaa tgcctacctt 383221 gtgaaccgaa cgcagctttc agctgaagac gtgaaggcgc acctgaaaaa acagcttcct 383281 gcttacatgg tgccgcaaac ctttaccttc ttggatgagc ttcctttaac gacgaacggg 383341 aaagtcaata aacggctgct cccaaaacct gatcaggatc agctggcgga agaatggatt 383401 ggaccgcgga acgagatgga agaaacaatc gcacaaatat ggtctgaggt tctcggcaga 383461 aagcaaattg gcattcatga cgatttcttt gcgctcggag ggcattcctt gaaggccatg 383521 accgccgcgt cccgcatcaa gaaagagctc gggattgatc ttccagtgaa gcttttgttt 383581 gaagcgccga cgatcgccgg catttcagcg tatttgaaaa acgggggctc tgatggcttg 383641 caggatgtaa cgataatgaa tcaggatcag gagcagatca ttttcgcatt tccgccggtt 383701 ctgggctatg gccttatgta ccaaaatctg tccagccgct tgccgtcata caagctatgc 383761 gcctttgatt ttattgagga ggaagaccgg cttgaccgct atgcggattt gatccagaag 383821 ctgcagccgg aagggccttt aacattgttt ggatattcag cgggatgcag cctggcgttt 383881 gaagctgcga aaaagcttga ggaacaaggc cgtattgttc agcggatcat catggtggat 383941 tcctataaaa aacaaggtgt cagtgatctg gacggacgca cggttgaaag tgatgtcgaa 384001 gcgttgatga atgtcaatcg ggacaatgaa gcgctcaaca gcgaagccgt caaacacggc 384061 ctcaagcaaa aaacacatgc cttttactca tactacgtca acctgatcag cacaggccag 384121 gtgaaagcag atattgatct gttgacttcc ggcgctgatt ttgacatgcc ggaatggctt 384181 gcatcatggg aagaagctac aacaggtgtt taccgtgtga aaagaggctt cggaacacac 384241 gcagaaatgc tgcagggcga aacgctagat aggaatgcgg agattttgct cgaatttctt 384301 aatacacaaa ccgtaacggt ttcataaatg aagtgatgaa aggaggagac agccaatgag 384361 ccaactcttc aaatcatttg atgcgtcgga aaaaacacag ctcatctgtt ttccgtttgc 384421 cggcggctat tcggcgtcgt ttcgccctct ccatgctttt ttgcaggggg agtgcgagat 384481 gctcgctgcc gagccgccgg gacacggcac gaatcaaacg tcagccattg aggatctcga 384541 agagctgacg gatttgtaca agcaagaact gaaccttcgc cctgatcggc cgtttgtgct 384601 gttcggacac agtatgggcg gaatgatcac cttcaggctg gcgcaaaagc ttgagcgtga 384661 aggcatcttt ccgcaggcgg ttatcatttc tgcaatccag ccgcctcata ttcagcggaa 384721 gaaagtgtcc cacctgcctg atgatcagtt tctcgatcat attatccaat taggcggaat 384781 gcccgcagag cttgttgaaa ataaggaggt catgtccttt ttcctgcctt ctttccgatc 384841 agattaccgg gctcttgaac aatttgagct ttacgatctg gcccagatcc agtcgcctgt 384901 tcatgtcttt aacgggcttg atgataaaaa atgcatacga gatgcggaag ggtggaagaa 384961 gtgggcaaaa gacatcacat tccatcaatt tgacggcggg cacatgttcc tgctgtcaca 385021 aacggaagaa gtcgcagaac ggatttttgc gatcttgaat cagcatccga tcattcaacc 385081 gtgatcaaaa gcggacagct tcggctgttc cgcttttttt gtgttgaatg ccaatttctg 385141 catggtataa tagtcgaaat actcaaataa aggcaggtcg aaacatgcgc acgtctccca 385201 ggatgaaatg gtttgtattg ctgtttacgt ttgttttcgc catcggaatg aactcattca 385261 gaaattcctt tcaatttttt atgctgccaa tggcagacgc cttccatgcc gacaggtcgc 385321 tgatttcggt ttctgtcagc atttttatga tcacaaccgg catcgtccag ttttttgtcg 385381 gtttttttat cgaccgtttc agtgtcagaa aaattatggc gctgggagct gtttgcatca 385441 gcgcaagctt tttggtgctt ccttattcac cgaatgttca tgtgttttcc gccatttacg 385501 gtgtgcttgg cggaatcggg tattcctgcg cggtcggcgt gacgacccag tatttcatca 385561 gctgttggtt tgacacacac aaaggtctgg cgcttgctat tttgaccaat gccaactctg 385621 cgggcctgct gcttctctcg cccatttggg ctgcggctcc gtatcatgcc ggctggcaga 385681 gcacctatac cattttggga atcgtcatgg cggctgttct gctgccgctc ctcgtctttg 385741 ggatgaagca cccgccacat gcgcaagcgg aaactgtgaa aaaatcttat gattggcgag 385801 ggttttggaa cgtgatgaag caatcccgcc tcattcatat cctgtacttc ggcgtgttta 385861 cttgcggatt tacaatggga attattgatg ctcacctcgt cccgatactg aaggatgcgc 385921 atgtctctca tgtcaacgga atgatggccg cgttcggggc atttatcatc attggcggat 385981 tattggcggg ctggctgtca gatctcctcg gcagcagaag cgtcatgcta tccatcttat 386041 ttttcattcg gctgctcagc ctcatttgcc tgctcattcc cattctcgga attcatcaca 386101 gcgacctttg gtacttcggg tttatcctgt tattcgggct cagttacaca ggcgtgatcc 386161 cgctgaccgc ggcgtcaatt tcggaaagct atcaaacagg attgatcgga tcgctgttag 386221 gcatcaattt ctttatccat caggttgccg gagctctcag cgtgtatgcg ggcggtttgt 386281 tttttgacat gactcatggt tatttactga ttgtcgctgt gtgcatcgtg tttgtgggtt 386341 tatcggctgt aatagagctg gtgccgtttt tagataaaca gaaggcaaaa gaaacccacc 386401 attcaatata aaaggatcag cactgtcaat gctgatcctt tttaaatttg agtttttttg 386461 tttcggtatt tttaaggata atctccttga atctgttcat ctcctcttcg gagtgaaaaa 386521 aatgtttggg gatcgcaata tattggccac ttgatgtatt gaccctgaag atatttttat 386581 attcgaaaac agctgtaatt tcatcccaat tgaaaatgag gtcatatttt ttagaacata 386641 tacgaattcc ttcttggttc agagtatatg ttcttttgga tttcatccgt tcgttcttct 386701 tgtatgctct ggaaaacttc acatatagaa gaaggaggag cagcagtgta aacagaacgg 386761 acatcacgat aatcaacata ctgttcataa acaagttaag cgcgtcactt ccataaacga 386821 tacggggcca tccgttaatg aagttaactg cagcaaatat ggcgcaaaac aatagaaagt 386881 aaaagcatga tatttttgcg atttgataaa aaaagatttc tcttacatcc ttaaaagtga 386941 tttctcctgg aagattgata ctttcactag catattgaat catacggtaa acctacacct 387001 ctaaccatgt ttttcctttt agtctagcat aatttctcat ttttttgcag gcataccagg 387061 gcgctttgtt tttttctcca gattgatatt gctccccacc acgccaatca taatacaaac 387121 agccccggca agatgatacc aggccaggct ttcgttgaga atcacaaatc ctgcaatcat 387181 cgtcacaatg gtagatacat gattaaaagc gctcatttta aacgcctcaa ttcgcgacag 387241 cgtatagtta gacagaaatg aagtgacaag tgaagacagc acgcccaaat acacaatggc 387301 gagaacgaag ccgggctccc ggaacggcag aaaataagtg ccgactgttc ccgccgctcc 387361 gtgacgcaca agggcgatgg cgttgaagac gacaaagccg atggctgaca tgatgtaggt 387421 gagctcggtc agcttgaacc gctgcgtcat ttttctggca gcagtattgt acatcgctga 387481 agacaaagcg gacaatagga tcagcaaaga cccttttaag ctggctgatt ccacgtcaac 387541 gcctttcatc acaaaaataa acatgacgcc ggcaacggat aaaaccgtga accccttttg 387601 cgtccacgtt gggcgttcct ttaaaacata agcggcaaag accatcgtga aaatcggaat 387661 ggctgcctga ataattcccg cttcagagga ggacgagtac acaaggccga atgcctgaaa 387721 gctgaaaaat aacgcgggat acagcagggc gagcggcaaa atgtcaatga cgtcctttac 387781 gcggattgat agctttaccc agccgaataa gatcggtaca gtggccgcag caaacgcaat 387841 ggtgaaccga tgcgccaaaa tatcaaacgg ctctgctgtt tgcagtgcga tttttacgaa 387901 tagaaaggat aaaccgataa tgaacgaata taaaatagcc gctatataag cgggggtttg 387961 ctgatgttta accataatgg gaagggctcc tttacctgaa ttgcagcgcc ggtcgctccc 388021 tttattgtat ggccgcggtc agaacggtac aatgagaaaa acaatgaact gtaccggtac 388081 aaaacagggg gagaaggcat ggagaaatat atgagtctat taacgaggat agaggagatg 388141 atgcaaagca cctcatatca agaaggagac aggcttccat ctatccgtca gctgtccgcc 388201 cgctaccaag tcagcaaaag cacagtgatc cgcgcgctgc aggagctgga aaagcgccac 388261 cttatctatt ctgttccgaa aagcggctat tatattgtga aaaagtcagg gaaatcaaaa 388321 agcgggcagc ctggccccat cgactttgcc acatctgcgc cggatcccga tgtgtttccg 388381 tatcttgatt ttcagcactg catcaacaaa gcgattgata catacaaaaa cgatttgttt 388441 atttatggga cgccaaaggg gcttccatca ctcatccgcg tactccgaaa gctcttggcc 388501 actcaacagg tatttgcgga tgaacggcat attttcatta catcaggtgt ccagcaggcg 388561 ttatccttgc tttgtgccat gccgttccca aatgggaaag agaagatcgc cattgaacag 388621 ccgggctacc atttgatggt cgaacagctt gagacacttg ggattcccgc catcggggtg 388681 aaacgaacgg aagaagggct tgatatagcc aaggttgagc ggttatttca aacagaatcg 388741 attaaatttt tttatacgat gccgcgcttc cataacccgc ttgggtgctc attgtcagag 388801 cgtgataaac aggagcttgt gagactggca gaagcgtatg atgtctatct cgttgaggat 388861 gattacctcg gtgatctgga ggaaaataaa aaggcagatc cgctgtacgc atatgatctg 388921 tcctcacatg tcatctattt gaaaagcttc tcgaaaatga tgttccccgg cctccgcgtg 388981 ggggcggctg ttttgcccga agcgctgact gacacgttct atgcgtacaa aaagctgaac 389041 gacatcgact gttcgatgat ttctcaagcg gcattggaga tttacctgaa aagcggtatg 389101 tacggcaggc ataaggagaa aatcagagat tcttataaag agcggtcgct gaggctacat 389161 caagccattc gaactcacag gcagctggga agcggacgct ttacgttctc cagcgggcag 389221 gcaccctgta tgcacaccca tctggtgctt cctcaggatc tgcccgcctc aagagtgatt 389281 catagactgg aaaaacaagg ggttctcctt gaggcgatag accgtcatta tttatcagat 389341 tatccgaaag aaaatctatt aaaaatcaat atttccaatg tgaaaacgga agatattgag 389401 cgcggtgtca agctgttgat gagccattta taaaagctct tcgtacgaga ccattgtgat 389461 atcctcgggg aaatcagggt gtacggcgca tacagccatt ttgtagccgg gatcgacctc 389521 atacgttttg atatagcatg gggaatggct gtccggaagc tcaatggata cttgtccgtc 389581 ctggtgcagg cgcactgaaa aggaatcaag cggaagcgat aagcctttgc cttccttgtt 389641 tgataaagct ttctttcatt gaccatagat gataaaaata gtctgtctgc tcgtccttgt 389701 cttttgctaa aaggtcgctg tactctgttt ttgaaaagaa gcgcttggcg atctcaaggc 389761 tgatcggttt cgttttttcg atatctatgc cgatcggctg tgaatcaaac gcgcaaatga 389821 cccagcgtcc ggagtgagaa atgttgaaat gagcgtcggg aagatcaggg atgcacggct 389881 tcccgtattc ctgcgtgcta aagcggatat cggatttgtc caactgatac tgcctgctta 389941 tgactgagcg aacgagcaca tctcccagca gggtgcggtg agcatcttct ttatgataaa 390001 atctccggca tttctcccgt ttttcaggtg atatgaaaga catgaaccgt tcattttctt 390061 cctgtgaaag cgggcggtcc atataaattc cgtaaatctt cattctagat cctccgtctg 390121 caaaagattg tcaaaaccat cctatcatac ttccacaaga ctcatataga ggagaaaata 390181 aaaaaacaaa gccaaggcgg ctttgtttta gtgtacaggc ggagatgctt tcactgcggc 390241 tgtccgcctt gccacagcat aattcagcaa ctggattgac tggggcaatg aaaaacgcaa 390301 aataagtccg gtgaggatgg cggtcaaaat ggtgccaaaa ccgatcggtc cgcccatgcc 390361 ccatgccgca aacaaaatgg ttaattccat gccgttccgc acccattgca cattccagcc 390421 ggttttttct gtaatcagca tcatcagtga atcacgcggc cccgcgccaa ggcctgctga 390481 tacataaaca ccgacgccgt aaccaatcag caccacgcct agagagaaga cgatgatcga 390541 gcctgtgtag gtcgagaggg caggcagaat gaaattgaaa aaatctataa atacaccaat 390601 gagcaccata ttcaggaggg caccaatttt cggccaagct ctcgtaaaca atgacgtgaa 390661 tccgacgatg agcgctccaa taatgatgga ccactggccg acggtaagcc cgaagtgctg 390721 aaacaggctg taatgaaatg catcccacgg actaatgccg agtgcttttc cttctatcgt 390781 cagggataca ccaaaagcca aaatgatcaa accggcaaaa taaaatgtcc agcgcagaac 390841 aagttcttgc ttcacgtgag gtcccttctt tcgtaaaaat cagtcgattg tcattgtagc 390901 acatctgaca gaagggcgga ataggcgaaa ggggctcaac aaaaaaacag ggccgccgga 390961 ggcgccctgt ttcagcgtgt tggcaaaccc ttgcattcgt tgtcaggcct gtgcttcggt 391021 gctcacgaat ttaacattag ctgtgctcca atgctcgccc ttcctagact tcaaaggttt 391081 tcaatcacgc tgaaaatcac aaaatcctaa aacgaatatc gttttaggat tttgtcaata 391141 atctgaaaca gggcgctgac gctctgtttt tcttattaca gcgggttcaa aatccggttt 391201 aagaaccgct gtgtccgttc ttcttttggt gcggagaaaa tttgctccgg cggtccctgc 391261 tccacgataa cgccgccgtc gatgaagatg acttcatccg caacctcctg cgcgaacttg 391321 atttcgtggg tcacgacgac catggtccag ccttcattgg ccaagtcctt gataaccttc 391381 agcacctctc cgacaagctc gggatcaagc gctgaggtcg gttcgtcaaa cagcatgagc 391441 tcaggctgta tcgccagtgc gcgggcgatg ccgacgcgct gctgctggcc gccggaaagc 391501 tggaacggat ataaatccat tttgtccttc aatccgactt tatcaagaag ctgaatcgct 391561 tcttttctga cttcctcttt gttccgtttt tgcacctgaa cagggccctc catcacgttt 391621 tcgagggctg tgcggtgcgg gaacaggtga tacgcctgaa acaccattcc ggattttcgg 391681 cgaagcttta ggatatccgc ctgtttcacc tttttggaga aatcgatgga gaaatcatca 391741 aatgcaagct ctccgcgatt cgggatctcc agagcgttca ggcagcggag cagcgtcgtt 391801 ttccctgaac ctgaaggccc aagtatggcg atgacttttc ctttttcaat cttcatatct 391861 atctttttta aaatttcatt ttcaccgaat gatttgttta atcctttaac ggtaagcata 391921 ctcggaacct ccttatttgg ccacgtagcg gtcaagacgc cgttcgatga catgctggac 391981 gagtgagagc aggaagcaga taatccaata aataaaggct gcttcaatat agatcactaa 392041 aatttgatca agattccgcg cgccgatttc ctgggctttt ctgaacagct cagcgaccag 392101 aatttgagag gcgagggatg tatctttaat caggctgata aaggtattgg ataatggcgg 392161 gatcgacaca cgaaacgcct gcggcaaaat gacgcggaac agcgtttttt gatgtgtcat 392221 gccaattgtg tagccggctt cccattgccc tttcggcacg gataaaatag atgcccgaat 392281 gatttcagat gcataggcgc cgacgtttaa tgaaaaggcg ataactgcgc ttggaaatgg 392341 atctaatgtg acgttaaagg ccgggaacag atagaaaatg atgaacaatt gaacgagaag 392401 aggagtgccg cgtattgcgg atacgtatac gctgaacacc catctcaaag gtctcacttt 392461 cgacattctg gcaagcgccg taatcagcgc caggatcatt ccgaatataa aggaaagaat 392521 cgtaagggga atcgtatagt agattccccc tgaaagtatc ggccagaatg actgctgcac 392581 cagatcccac gggatcgccg tgccaagcgt caatgccggc agattattta gaaacatctt 392641 cgccgaacca ttttttagaa attttagaaa gagtcccgtc ctctttcatt tcttttaatg 392701 ctttgttgac ttgatcaaca acctcgccgc ttcctttacg gaacgtgaaa tatgttgact 392761 gaggctcacc tgtttcaaac gcgattttca cgtttttatt gccagatgtt tttaagtagt 392821 tcaatacggc aagcttatcg ttgtatgtca tatcgacgcg gccttgctgg atcatttgaa 392881 gggcctgcgc catgccttca acgccttcta ctttagcgcc ggcatttgta gctaatttgt 392941 tgtagttgct tgtcagtgat tgagctgacg tttttccttt tacatctgct tcagacttaa 393001 tatcgttgtt gtcttttttc gttacgacaa cggctcttga tgttgtgtat ttatctgaga 393061 aatcatattt gtcttcacga tctgtttttc cgacttggtt ggcaacaacg tcaaaccgtt 393121 tggaattcag gccggcaaac atactgtccc attgtgtttc cttaaagtcg actttaagcc 393181 cgaggcgttt tgcgacttct gtgataactt cgacatcata gccagtcagt ttatcagtgt 393241 ctttgtcgtg gtaagtgaac ggctcatatg ttccttccgt tccgactgtg agcacacctt 393301 ttttcttaat tgaagcccaa agatcgccat ctttggcatt atcttttgac tgattgtcat 393361 ttcctgctcc gcaagctgca agagctgcaa tacttacgac catgaataaa gccaataatg 393421 cttttttcat cttattcccc acttttctgg ttgattttat tgaaataaaa aattagctta 393481 caaatctaaa ggataacttt tttttagtat gagtcaagta tttggttttc ataagacaaa 393541 atcttttaaa ataaatccaa aaattgctgt gccggtttag gcaaataact gtccgttctc 393601 cacatgacag ccggtgtcat aatgaaggga ttattttcga tatggacggt gtgaacgtga 393661 tttctcatat gaacgggaat cattgtgaca ggcaaaatag acgcgccgaa tccggatgac 393721 acgaggctga gcaaagttgc agagtcgtgg cattcacaaa caatgcgcgg ctccaggttc 393781 aaacgatgaa attcattcat gacctgatta tagacgcctt ttccgttgac aggccgcagc 393841 aggatcagcg gaaatgaagg aatgtccacc atcttaatgg tgtctccgca cggatatccg 393901 gcttcatctg aaagcacgag cacacatgga atgtcatcaa gctgcttgaa ttgtactgtg 393961 tcacttttga tcagtgttgt cgtgaccgcc gcatcgattt gccggctttc cagcagttcc 394021 aacagtgtcg cgggttcatt ttcccaaata ttaaaggtga gatgggggta tctctctttg 394081 atctgtgtta ctttttcaag catcagagcc gcgcaataaa tcgttgatcc cacggcaagt 394141 gtaccggcta cttcctcctt cagctcctgt acctcaatga ctgcatcttc aaacctatgc 394201 agaatctctt ttgctctttt tagaaaaaca gctccttcat atgtaagagt catttgtttt 394261 ttcttgttac ggtcaaacag aacaacacca agttcgtcct ccagctgttt gagctgcctg 394321 cttaaaggcg gctgcgccat gtgaagcttt ttggctgcgg acgtaatttt ctgttcttgg 394381 gcaatggtaa tgaagtatcg aagctggcga atatccaaaa gaaagcgcct ccttatcata 394441 ccttttaggt attaattata gatttaatag atatttttca tatggatata tcaggagtat 394501 gattgaaatg aaagcagaat tcaagcgtaa aggagggggc aaagtgaaac tcgttgtcgg 394561 aatgacaggg gcaacagggg ccattttcgg ggtcaggctg ctgcagtggc tgaaggccgc 394621 cggagtggaa acccatctcg ttgtgtctcc ttgggcaaac gtcacgatca aacacgaaac 394681 aggctatacg ttacaagaag tagaacaact ggccacatac acttactcac ataaggatca 394741 ggcggcagcc atttcaagcg ggtcgtttga taccgatgga atgattgttg cgccgtgcag 394801 catgaaatct ctcgcaagca ttcgcacagg aatggcggat aatctgctga cacgtgcggc 394861 ggatgtcatg ctcaaggaga gaaaaaaact cgtcctctta acgagagaga cgcctttgaa 394921 ccaaattcat ctcgaaaata tgctagcgct tacgaaaatg ggcaccatca ttcttcctcc 394981 gatgccggca ttttataatc ggccgagaag cttagaggaa atggttgacc atattgtttt 395041 tagaacgttg gaccaattcg gcattcggct tcctgaagcg aagcgctgga atgggattga 395101 aaaacaaaaa ggaggagctt gatcatggct tatcaagatt tcagagaatt tctcgctgcc 395161 cttgaaaaag aaggacagct gcttacagtg aatgaagagg taaagccgga accggattta 395221 ggggcctccg cacgggcagc cagcaatctt ggcgataaaa gccctgcgct cttatttaac 395281 aacatttacg gctatcataa cgcgcgaatt gcgatgaatg tcatcggctc ttggccaaac 395341 catgccatga tgctgggcat gccgaaagac acaccggtaa aagaacagtt ttttgaattc 395401 gcaaagcgtt atgaccagtt tccgatgccg gtcaaacgtg aggaaacagc gccatttcat 395461 gaaaatgaaa tcacagaaga tatcaatttg ttcgatatac tgcctctttt cagaattaac 395521 cagggtgatg gaggctacta tttagacaaa gcatgtgtca tttcccgtga tcttgaggac 395581 cctgacaact tcggcaaaca aaatgtcggc atttacagaa tgcaagtcaa aggaaaagac 395641 cgccttggca ttcagcctgt cccgcagcac gatattgcaa tccatctgcg ccaagctgaa 395701 gaacgcggca tcaaccttcc ggtcactatt gcgctcggct gtgagccggt cattacaacg 395761 gcggcatcga ctccgcttct ctatgatcaa tcagaatacg aaatggcagg tgcgattcaa 395821 ggcgaaccat atcgcatcgt caaatcaaag ctgtctgatc ttgatgttcc gtggggcgct 395881 gaagtggtgc ttgaaggtga gattattgcc ggagagcgcg aatatgaagg gccgttcggt 395941 gaattcacag gccattattc cggcggacgc agcatgccga ttatcaaaat taaacgcgtc 396001 tatcacagaa acaatccgat ctttgaacat ttatacttag gcatgccttg gacagaatgc 396061 gattacatga tcggcattaa cacatgcgtg ccgctttatc agcagttaaa agaagcgtat 396121 ccgaacgaaa ttgtggcagt gaacgccatg tacacacacg gtttaatcgc gattgtttcc 396181 acaaaaaccc gctatggcgg atttgcgaaa gcggtcggca tgcgcgcact cacaacgccg 396241 cacggactcg gctactgcaa aatggtcata gtcgttgatg aggatgtcga tccattcaac 396301 cttccgcagg tcatgtgggc gctttcgacc aaaatgcatc cgaaacatga tgcggtcatc 396361 attccggact tatctgtcct gccgcttgat ccgggatcca atccatcagg aatcactcac 396421 aaaatgattc tcgacgccac tacaccggtt gcgccggaaa caagaggcca ttattcacag 396481 ccgcttgatt ctccgctaac aacgaaagaa tgggaacaaa aactaatgga cttaatgaat 396541 aaataaggaa aggatgttcg aaatgcatac atgtcctcga tgcgactcaa aaaagggaga 396601 agtcatgagc aaatcgcctg tagaaggcgc atgggaagtt tatcagtgcc aaacatgctt 396661 ttttacatgg agatcctgtg aaccggaaag cattacaaat cccgaaaaat acaatccagc 396721 gtttaaaatt gatccaaagg aaacagaaac agcaattgaa gttccggcgg tgccggaacg 396781 aaaggcttga tccgcgtgaa ctgtatgtca gaccgtctct ttgagctgct tgacgggagc 396841 tgcctgaatg agaagcagca tgaggccttc gttctgcaaa cagtatcaga ggatggctgg 396901 ccgcatgccg ctatgatcag tgcaggtgaa atcatcgcgc tgagccgaac tgatatccga 396961 atcgctctgt ggaaaaacac aatgacttcg gccaacatcc ttcgcacagg aaaagcacag 397021 ttcacggcgt ggtggaaggg agcggcctat tatgtaaagc ttgaatgcgc gcctttaccg 397081 cctttgaaag atgccgaata tgaaagagac cgtttttcct gccgcatcgt ttcagtgaaa 397141 gaggacgttg cgaaatacgc tgatttgact tcaggtgtcc gtatacagct tcacagccct 397201 gaagaggtgc tgagcagatg gaaaaagacc ctggaagatt taaaacggta atatcgatag 397261 cctgacgcca tgcgtcaggc tttttttata taatgaaaac aaaagggggc gtgagaaatg 397321 gaacgtgcgg ggatctgtca ctcggacggc tttgatttag cttatcgaat tgagggcgag 397381 ggcgcaccca tccttgtgat cgggagtgcg gtttactatc cgcgcctttt ttcctcagat 397441 atcaaacaga aatatcaatg ggtctttgtc gaccataggg gatttgctaa gcctaagcgg 397501 gagcttcgtg cggaggattc gaggcttgat gctgtcttgg ctgatatcga aaggatgaga 397561 acatttcttc agcttgagga tgttactatc ctgggacatt ccgggcacgc ttttatggct 397621 ttagagtatg ccaggacata tcccaaacaa gttcggaagg tggcgctctt taatactgcg 397681 cctgataaca gtgaagaaag acagcgaaaa agcgaatcat ttttcatgga aacagccagt 397741 cttgagagaa agaaacgctt tgaaaaagac atcgagaatt tgccgcagga catcgacaaa 397801 gatcctgaaa ggcgctttgt gcacatgtgt attcgcgctg aagcgaaaag cttttatcaa 397861 gagcggccgc atgctgctgc cttatgggac ggtgtattca cgaatatgcc gatcattgat 397921 gaattatggg gcaatacatt tgcccggatt gatcttcttc agcggttagc tgatgttcgt 397981 atgccggtgt atatcggatt agggagatat gattatttgg ttgcgcccgt ttcgctatgg 398041 gatgctgttg acggtttata tccccatgtt gataaggtta tttttgaaaa gagcggccat 398101 cagccgatgc tggaagaacc ggaagccttt gatcaaagct tcaggaaatg gcttgatcaa 398161 taaaaaacag cccgcagatc aacatccgcg ggctgtttct gattataaga cccctttcat 398221 cgcgcgtttg atcaccggcg agagcagcag gagaatgccg ccaagaacga tagaaatcaa 398281 accgatggtg ccgaagtaca ttgtttcagg aattttatca aacaatccgg ctacttgggc 398341 attgatcgct tgggctgctg cgttcgtcag aaaccacata ctcattgtct gtgcagagaa 398401 ggcagctggt gccagtttcg ttgtcacgga taaaccgact ggagacaggc acagctctcc 398461 aagcacgaca agcaggaagc tgagaacgag ccaaagcggg cttacgagtg cttcttttcc 398521 ttgcatagca gggaatacca taatgataaa tgacaatccg gctaaaataa ttccgattga 398581 gaatttaact ggtgtagacg gctgacgttt gccaagcttc atccagagcc atgcgaatat 398641 tggcgcaaaa atgacaacaa acaatggatt taatgattgg aaccatgatg actgaagttc 398701 gaatccgccc aatgaaagtc ttatgcgttc atcagcgtat accgcaagaa tggtcgctcc 398761 ctgttcctga atggcccaga acatgacagc accgataaac aaaggaacgt aagcggcaag 398821 acgggatttt tctgttttgt ccgctttttt gcttgtaaac atgatgatga aataaatcac 398881 aggaatcaaa ataccgagaa tacttacaag gtcaatgaaa cgtttgatcg tcagcacgcc 398941 tgtttgtaca gagataatca ctgcgatcgc cacaatgata acaccgattc cggtgccaat 399001 tgcagatttt ttagacagcg gattcggcac attggaacct gcaagcccga ggtttttctt 399061 tcttgtcaaa gcaaatacga taagtccgag aagcattccg accgcggcag ctccgaatcc 399121 gagatgatag ttgtacttct gtccgagtgt tccgacaatt aacggcgcga gtaaaccacc 399181 gaggttaatc cccatgtaga aaatactgaa acctgagtcg cggcgcgggt cttctttcgt 399241 gtaaagatcc ccaactacgc ttgaaacgtt tggttttaat aagcctgttc cgacaatgat 399301 aagcaccata ctgatataga atgctatcga actgcccgga taggcgagtg caatgtggcc 399361 gaacataatg aatatgccgc cgtaaaacac ggtgtttgcg gtaccgaata cccggtcagc 399421 gagccatccg ccaataatgg tggacatgta tacgagtgat ccgtaaatcg acataatggc 399481 aaccgcagtg cccttgtcaa agccgagccc tccgtttacc gtctctgtat acaaatagta 399541 aagtaagatt gctctcattc catagtaaga gaaacgctcc caaaattcgg tgaaaaatag 399601 tgtaaatagt cctcgcgggt gaccaaagaa ccctttttgc gggacgcttt taatgatact 399661 ttcgttatca atcgaagcca tgtcagccaa accctttcta aaaaaagtgt attataaaaa 399721 tcatattctt atataatact tgtgtcaata taatttatac tcatttcaaa tagttccata 399781 ttggaaaaat tataaatacc taaaaatagt gatttcctcc taatttttaa actttttatc 399841 gtgagatttt cttacacaac tattccttta tattttttta ataaaatttt agagaaatgt 399901 acaagcagat cgggcctttg tgagtaacat gatagtaatc atagagaagg aggctcgcaa 399961 ttggctgaat tcatattaaa tgcagcggat ttcggtgttc ctagagatgg taaaacggat 400021 tcgacagaac ggattaatca gtgcctcagt acagctgttt cgaaaggcta tcatactgtc 400081 tggtttccaa agggaacata tttaatagac gcaacgcttg gcggagatct taatcagagg 400141 tttcgaaacg cggggatcat tgttcccggc aaccttgaga ttatgatgga ccccgaatgt 400201 atcatgaaag tgataccgaa tagttcgtgg ggttattccg cattttatgt aggcaagcaa 400261 gagaatataa ctatttccgg aggacaaatt atcggcgaac gggatgagca tacgtatgcc 400321 tcggcgggga taaggtcaac ccatgaatgg ggctttggca tatgtattga aggatgctcg 400381 aatgttgtca ttgatgatgt gaaaatttcc gattttaccg gcgatgggat catagtcagc 400441 ccaaggggat taaagaccaa tcaagattat cgaacgtcag agcaaattat catccgccgc 400501 tgtgaggttc ggcggtcgag gagaaataac atttccatta ccggatgtga catggtcacg 400561 gtggaggaat gcttgattga agatgccgga acggggaatg gaacagcgcc gaaattcgga 400621 attgacattg aaggatatgg cgaaggtgac gttgattatg aggaaccgat taatgtatca 400681 attcgcaata accactttgt tggaaacgtt tcaagttctg tgaccaattt taacgggtat 400741 ggcattttaa tagaaggaaa tcactcagac aatacaatca gctacggata tgggacgcaa 400801 acagtgatca agggcaatat tctgagacgc cctgaagacg cggcggctgc gccaagagtc 400861 gggataaccg gactcggtgt atcacaagga aaagagacca gtgatgcagt gatcgctggc 400921 aacctcatta ccggattttc aactggaatt gatgtcaggg gaaagagcgt tcttgtgacg 400981 aacaacaaaa tcagcaactt tgaaaacaca gggatattgg tttatcagtc ctccgacgta 401041 aaggtagacg gaaaccaaat tcaaaacgga ctgtctgaaa caaggcgcag catcggtctt 401101 cgcgcagtgc tgtcagatga catcgcattt ctgaataact gtctcattca agtcgttgac 401161 ggtgtgaacg tttccggcgg aaatatgatc attaaagata atctcctgag aaaattcagc 401221 cggggcattt ggattgctca agggaacgcg gtgattgaag ggaatacact gaatcctgac 401281 gcgtttgaag cagtgccgga atcatattct gtttccgtca caaacaatgc cggcgccatc 401341 atcaaaaaca atacatttaa agagttcaaa aattacccca tttattgctc cacaagtgca 401401 aaaacctcaa ttatcggcaa ccacttagag cgatccccgc ttttggtcac catctatatc 401461 agcgcaggtg tgcatgagat ttttgataat accatttcag tcaacagaac agccgggaat 401521 ccgattgtga tttatctcaa tggctctgca ggctctatca tctctggaaa caccatcaat 401581 aacctctccg cgggcactgc gacagctatt caaacaaaca cgtcaaccaa ttccaaaatc 401641 atcggcaacc gcatttttaa agggaccatc aacaaacaca gcagtgatac aatagacggc 401701 aatatgattg tctgaaaaaa gcgcccccct ttaggggttc ttttttttcg atttatagat 401761 cacgtacatt tctctcacaa gtactaacac aaaaaataaa agcacgaccc attccgcaaa 401821 tgttgtcatc ttaaagctgg acatattgtt ataaacggct tttgttaaac tgaacccttg 401881 aagcatgtcc atcaacacag aaatagctaa taaacaaatt aatatgaatc cggtcacgcc 401941 caatatcttc atgcttcatc atcctccgct tttagtgtct atctttggcg gagaagttat 402001 accgcatcta accctaatgc ataatctcaa ttttaaaagg aagaatatga gaaaacgaca 402061 aggaaaggta tttgtgtatg cctttatttt ctaagcgaaa gaacaatacc gattcaaaag 402121 acaagcagaa tacagacgaa aggaatcagg aacagcagca agaaaaagaa aggccggttc 402181 tcatttctcc aagtttagca aagaatatag cggaaacgaa aaaggaagtc ggaagcagct 402241 ctgacgtcat cattcgcgag attaaaatcg gggagcagga tcatgtccac ctagctgtta 402301 tctatatttc tgggctggtc gataataaca cgatccatga gtcgttaatt gacccattgg 402361 tacaggatga gtctatccag aatactcatg cgatccagca aattcttgaa aaaacgctcc 402421 cgctgggcgg ggtgaaagcg gaaaagagct gggacaagct tttttccgag ttaatgcttg 402481 gcaatgcgct catttttgct gatggccatg atgaagcttt gatttgcagc actcaagggg 402541 gagagcagcg ctccatccaa gagccgagca cccaggtgtc attccgcggc ccgcgccaag 402601 ggtttacaga gtctctgcaa accaatattt ccatgatccg gcgatacatt aaaaatccga 402661 atttatgggt tgaaaaaatg aaaaaaggtt ctgttacgaa tacggatatc gctctcatgt 402721 acattcaagg aatatgtgat gaaaaggtgc tgaaggaagt gaaacagcgc ctggaaaaaa 402781 tagatattga cagtattttg gaatctggat atattgagca gctgattgaa gatgaaacct 402841 ttacgacgtt tccgactatg tatcatacag aacgccctga tgttgtagcg ggtaatctgt 402901 tagaaggaag attcgcgatt attgtggacg gaacaccgtt tgtgcttatt gccccagcct 402961 tatttgtcca gttttttcag tctgttgagg attattattc gcgttttgac attgcgacaa 403021 gcataagaat tcttcgtgtt ttagtctttt tcatttcgct tgtggcacca gctgtatacg 403081 tggcagccac gacgtttcat caagaaatga taccgactca gctgttagtg gtcattgcgg 403141 cccagcggga aattgtcccg tttccggctg ttgtggaggc gctgacgatg gaggttgctt 403201 ttgagattct gagggaagcg ggagtcaggc tgccccgggt tgtcggctcg gcagtgtcaa 403261 tcgtaggcgc gctcgtaatc ggccaggctg ccgtacaggc tggtatcgtc tctccggcaa 403321 tggtgattat cgtggcactc accgcgattg cgagcttcgc aacaccggcg tttgcaatgg 403381 cgatttcagc ccggcttatt cggtttatct ttattattgc ctcagctgtt atgggttttt 403441 acgggctgat tttagggatc attatgatgt ttgtccactt atgcagtctt cgttcattcg 403501 gcgttccata tatgtcgccg cttgcacctt tttcttcaca aggcgtaaag gacgcgcttt 403561 tccgggttcc gtggtgggcc gatgaaaaaa ggccggaatc ggtcagcaag gaagataagg 403621 tgcggcaggg gaaagatcaa cgcccagagc cggccgcttc acgaggaatg gtgaacaaag 403681 atttggaaga aggggatcag aatggtacgt aaatgtctat tagccgttct catgcttttg 403741 agcgtcattg tgctgcccgg ctgctgggat aagcgggagc tgacggatct tgcgattatc 403801 tcggcgattg gcatcgatcg gacaaacgac agcaactacg tgctgcatct tcaaattatc 403861 aatccaggaa atgttgccgg cggccttcag ggaggcggtg ctggagacag gccgcctgta 403921 tctgtctatt cgattgaagg taacaatata acggaagcac tcagaaaagc ctccatgaag 403981 gtatcacggc ggctttattt tgcccatacc aatctagtcg tgatcaatga aaagctggca 404041 aaagaagaag gtttggattt tgtattagat aatcttgacc gggacacaga attcaggaca 404101 acagcaacat tcgtcgttgc ccataaaaca aaagcagaaa atattgtgaa aatcttgacg 404161 ccgattgata aaattccgtc aaataaagtc aataaaacac tcgatttcac ggaggcacaa 404221 tacgggcggg tggtcaaaat caatattcag gacgttttga aaacacttgc cgccaacact 404281 atggcaccgg tcatccccgg atatatgatg attggtgacg ataaaaaagg agtcagcatg 404341 gaaaacacgc aggcgactga cccgaaagcc attcttcagg cagatggttt ggcggttttt 404401 gataaggcag gatatttaaa gtattggctg gaagatgatg aaagcgtggg ggcagtctgg 404461 cttatgaata agatccagca tacgtttatt aatgctgact ggggcaagac gaaggatgcg 404521 gtcagcttgc aggttaccca tcaagataca aagctggtac cgaaaatgcg gaacggacgc 404581 ccgtacatcc atgtgaaagt gtcggttgaa ggtattatag atgctgtcaa ataccctttc 404641 caattgtctg atcccaaggt gctggccgct attgaaaaag cgctcaacaa agagcttgaa 404701 aaggaaatca gccatactgt gaaaaagatt aagaagaata aaatagattt tatcggtttt 404761 ggtgacacga tatatagaaa gtatccggag cagtgggaga aaatgaagga cacttgggac 404821 aaagaatatt tgccggaact gcccatcgat gtgaaggccg agacgtatat cagaaggacg 404881 ggattgcgaa acaatccgat caaacaccag tttaaagatg attaggtctg aagaaagggg 404941 aagtgacaga tggaaaaagc cagaataagc ataaggcagt tgtttgtcat gattatcatt 405001 tttgaactgg gcagctcctt attgattaca ccgggatcaa tggcgggcag ggatgcttgg 405061 atagcagttt tattaggctg tgcgatcgga ctgtttcttt tctatttgta tcaaggcatt 405121 tatcaatgtt atccgaattc ttctccgaaa gaatatatgg atgatatgct gggaaccaag 405181 ctgagctggc tgttttcatt tctctatatc ttgtactttg cctatattgc cgcaagggtg 405241 ctgcgtgact ttggagaaat gctgctgacg tttgcttatc atgatacacc tatcattatt 405301 gtaaatgctt tattaatggt agtaagcata tatgccgtaa gaaaaggaat tgaagtactc 405361 gcacgcgcgg ccgaacttct tttcggggcc atgtatttac tgggcgcgat cggccttgtg 405421 ctgattattg tctcagggac tatagacccg cacaatttaa agccggtttt ggcaaacggc 405481 atttctcctg tccttcactc tgttttcaca cagaccatgt acgttccatt tggtgaagtt 405541 gttttatttg tgatgatttt ccctaacctg aatgacagaa aagatgtgaa aaaaatgggg 405601 atgatcgcca tggctattag cggattgatt gtggcgctca ccgtggcgat taatattagc 405661 gtgcttgatg ttgatcttac actcagatcc cagtttccgc ttttaagcac gatccagaca 405721 atcaaggtcg aagaattttt agaccggctc gatgtctttt ttatgctggc gctgatcatc 405781 ggcggcttct ttaaggtcag cctctactta tatgccactg tggttgggac atctacgctc 405841 tttaaggaaa agaacccctc tcaattggct tatccgatgg gattgggcat cttaatcctt 405901 tctataacga tcgcgactaa cttttcggag cacttgaatg aaggcctgaa cgtggtgccg 405961 ctgtatattc atttgccttt tcaattattg tttccgctct ttctgtttat tgtggccgtt 406021 tggaaaaaga aacgaagaga gaagtcaaaa ggggaggaag caaaaaaatg ataaaaagag 406081 cggggggatg cggccgccgc tctttttatg ttcacttcta tataaaaggg ggatataggg 406141 tgcgcccctg tctgcactgg cagaggcgcg ttttgttata cgactgcgac gttttccttc 406201 acagtaaaac ttcctcttga aagtctgata ttgatgtctg acacttttgc aatttgttca 406261 tcgtgcgtca ccataatgac gcatttatct tccttgtgcg ccagatcctg aaagagccgt 406321 acgatctctt ttgatgtgtc ctcatcaagg tttccggtcg gttcatcggc tacgataaga 406381 tccgtgtcac agcagaaagc ccttgtaatt gatacccgct gctgctgtcc gccgctcagt 406441 gtgagcactt tttgccgggc ttgtttttcg ttgatgccaa ccttctgcag catgtcaagc 406501 gcatatgatt ctttgttctt ttctttagaa cctgtgattt ccatagcggt tgtgacgttc 406561 tgcaaagccg tcatatacgg gagcaggttg tacgcctgaa agacgattga tacatattga 406621 tttctgaaat tggttaagcc gattttagaa accgcttttc cgtcgtaaag gatgtttcct 406681 tcttttggtg cgtcaagtcc gcctgccaga gacaggaaag tggttttccc cgtccctgat 406741 gttccgacga ttgtgtagaa ttttcctttt tgaaagctga tgttaatatc ctgaaacaat 406801 ggctggcttt tgtttttata ccagtagccg acttgttgaa attgtaataa gctcataggt 406861 tccgcctctt tctattcctg ttttgtcaat atcgttttcg gatgaagccg cagtactgaa 406921 attgacggca gcaatgttgc aatgattgcg attaggatgc cgatcccgcc aagtataagc 406981 atgtcgttca tagaaaccgc gacgttcagt gaatcgataa cgtccacgtt ggatgaactg 407041 tggccgaaca ttttgccgcc catgccgcca ccgccgccgg gcatttgtcc gcttgcggtt 407101 tgcgttgaat cggttgatga actgatttgc tgggataaaa gctgatttcc aagctgattc 407161 gcgacgagat ttcccgtcac agatgcaagg ccgatagcga taacggccac aatcagaatc 407221 tcagtcaaga actgtccaat caatttccat cgtttttcac cgatggccat taacacgccc 407281 atttcgtatt tgcgctccct gattgacatc atgacaatca ggccaagaat gacggcgcct 407341 gccactgata caagatacac cacgttttta gagaaagaag ccacattttc aatcggtccg 407401 accatttgct ggtaaagctg atcgtttgta ttcagtgtgt acgtatcaaa gtcaattgat 407461 gttttcttcg ctgcttttac gaaagtatcc atatttttcg cgtcgtccat atagtaaaca 407521 gctgagtcaa tcgtattttt atagtcgtcg cctttcaatg ccgctgttgc tgtgtaaggc 407581 gtataaagct tgttataagg atttaagaaa gagaaatttt gggcttggtc atcacctgaa 407641 gatgttgttt tataaatacc gacgatcttc agttttactg ttgtatcctc atccgttgct 407701 gattcaattg tgatcgaatc gccaacgctt aaatcatttt cttccgctaa tgtttcgttg 407761 atcactgtta cttttttgcc gacatctgat tttgtaatcg cgcgtccgtc tgtgattttt 407821 gaatctccgt cagagaaatc atcgactaac gctgtgctga tgacaccttc aatagaaaga 407881 tcagcttgaa ccatttgcgg tccgccttgt cctccgcctt gactgttttt agcgtttgag 407941 cttgaactgc tggagctgga atcacttgaa ctagagcttt caatcgcatc aaagtttccc 408001 gcgttggctg aagctgatgt ggtgtaattg tagctcttca catgatcaag cgctgcaagc 408061 ttattcgcat cagacacttt gatcggtgtg gattcgaagc tgcgcttttc accgctgtcc 408121 tgctgttttt ccatttgctt ttggcggtca acctgaagtg tcacgcttcc accgagttcc 408181 tgtctggcca gttcgcttga cttttgtgct gccgactgga tggcgaggcc tgatagaaca 408241 aagacacata tgactgtaaa cacaaataat tgcaataacg tttttccctt tttagccttc 408301 atattccaaa aggcccgttt gataaagttc atttatgttc ctccgtatag gtatttttat 408361 tgataagacc gcctctgggg cgcgtcccct tgctgataaa ttaatagtag tccaaaggta 408421 tgaaaaaaat atgaacaatc tatttctagt tgatgaaata aaaactaaca attgtgaaac 408481 gcaaaacctt ctgtttaaaa tggtgctatt atataaaaaa gcatcaaaac aaccggagga 408541 tataatgaaa atattaatga tagaagataa tgttagtgta tgtacgatga cggagatgtt 408601 cttttttaaa gaaggttttg aagccgaatt cgttcatgac gggttagaag ggtaccagcg 408661 ttttacggaa gaaaattggg atctaatcat tttggatatc atgcttccat ctatggacgg 408721 cgtgaccatc tgcagaaaaa taagagagac aagcacggtg ccgattatca tgctgactgc 408781 caaagacact gaatcagatc aggtcatcgg ttttgagatg ggggcggacg attatgtcac 408841 aaagccgttc agcccgctga cattggttgc ccgcatcaaa gccgtcatca gaagatataa 408901 ggcgacaggc aaagcggtta ttgatgaaga tatgattgaa acggaatgct ttaccattaa 408961 taagaagacg agagaagtat tattaaacgg agagcctgta gaaaatctca cgccgaagga 409021 attcgatctg ctttattacc ttgtccaaaa tccgcggcag gtgttctcca gagaacagct 409081 gcttgagcag gtatggggct atcaatttta tggagatgag cgaacggttg acgttcatat 409141 caaacggctg cggaaaaagc ttgccagcga ggacaagcct ttcctgtata ctgtgtgggg 409201 agtagggtat aaatttgatg aagattaaat atttatatca gctgctgcta agccatatca 409261 gcattttgat tttagcgttt gtcattatca tttctctgtt ttcccacttt gtgaaggaat 409321 ttgcctatca gaacaaagta gaggaattga cgtcatatgc ggtgcagatt gcaaatgaat 409381 tccaatccgg ccaggtggac atgcgcaggc tctatcctta tcaggacatt ttaagcacaa 409441 gaaagacgca atttatcatc tttaatgaag agcagcagcc ttattttctt cctgaaggct 409501 ttcatcaccc accaagggaa cagctgaaga aatcagaatg gaataagctg aaaaaagggc 409561 agactgtcac gatcagggca gatggccgtt ttgatgatga agtgtccctt gtggcgcagc 409621 ctatatttgt tcagaacgaa tttaaaggcg ccgttctgct gatttctccg atcagcggtg 409681 ttgaacagat ggtcaatcag gtcaacctct atatgtttta cgctgtgatc agcacgcttg 409741 tgattacgat tcttgtgagc tggcttctgt ccaaattcca tgtcaagcgg attcaaaagc 409801 tgagagaagc gacagataaa gtggcttccg gcgattatga catccatttg gaaaacagct 409861 acggggacga aatcggcgta ctggcgtctg actttaatat catggcgaaa aaactaaagc 409921 agtcaaggga tgaaatcgag cgccttgaga agcggagaag gcagtttatc gctgacgtgt 409981 cacatgaatt aaaaacaccg ctgacgacga tcaacggttt ggttgaaggg ttgaacagcc 410041 atacgattcc tgaggataaa aaggataaat gcttctcgct gatcagtgag gaaacgaagc 410101 gcatgctgcg gctcgtaaaa gaaaatctgg attatgaaaa aatcagatcc cagcaaatta 410161 ccttgaacaa gctagacgtt cctctgatcg aggtgtttga aatcgtgaaa gagcacttgc 410221 agcagcaggc ggaagaaaaa caaaacaagc tgatgatcca agtagaggat cacgtcatcg 410281 tacatgccga ttatgaccgg ttcattcaaa ttctcgtcaa cattacgaaa aacagcatcc 410341 aatttacgca aaacggtgac atttggctgc gcggaatgga aggttataaa gagacgatta 410401 ttgaaattga agacacgggt atcggcattc caaaagagga tattgagcat atttgggagc 410461 gattctataa agcagatatt tcaagaacga acacagcata cggtgaatac ggactcggtc 410521 tctcgatcgt caggcagctc gttgaaatgc accagggcac agtagaaatc aagagtgaag 410581 aagggaaagg cacaaagttc atcatccgcc ttcctttaac ggcaaaacag caatagcata 410641 cagggcggcg catcaactga tgcatccgcc ttttttgcac accgcttcgg tttattgcgt 410701 gctcccgaaa acaaagattg cgtgtttttc gggttgggac ggcctataaa catgataaaa 410761 tatgacataa acagtttttg atgggagagg gtgaaggaat gaagagtggg gtaattcctt 410821 cttcagcggt cggtcaaaaa attaacgagt ggtacagata tatccggaca ttcagcgtgc 410881 cggatgccga agtgttaaaa gctgaaatcc agcaggaact gaaacacatg cagcatgatt 410941 ccaacttgct gctttattat tcactaatgg aattccggca ccagcttatg ctggattatc 411001 ttgagccgtt agagaaatta aatatcgaag accagccaag cctgtctgaa ttatcaagaa 411061 acattgacag caaccaggca gatctcaaag ggctgctcga ctattacgtg aatttttttc 411121 gcgggatgta tgaatttgat aagcgggaat ttatttctgc cattacatac tataaacagg 411181 cggagaaaaa gctctccttt gtcgcagacc atattgaacg ggctgaattc tattttaaaa 411241 tcgcggaagc ttattattat atgaagcaaa cgtatttttc attgattaat ataaaaaacg 411301 cctatgaaat ttacgtggag caggaaacct ataatgtgag aatcattcag tgccatttcg 411361 tcttcggggt caacctgatg gatgaaagaa atttcgaaca agccgcacgc catttcaaat 411421 tggcgctcaa catggcccaa gcagaacaaa aagcccagct ggttggaaga gcatactaca 411481 atctcgggtt atgctattac aatcaagacc ttctagaccc tgccattgat tactttgaaa 411541 aagcggtctc cacatttgaa agcagcagga tcgtcaattc tctcccgcaa gcctattttt 411601 taatcaccct gatttattat aaacagggaa aacatgataa agcttcggaa tatcacaagc 411661 ggggctatga atatgctaaa gaaacagacg atgcagacta tgccgtaaaa ttcgagtttt 411721 tgcaatccct atatctggat cagcccaatg aagaaggaat cgaacgatgt ttccagtact 411781 taaaaaataa aaatatgtac gctgatatag aggatttagc cctagaagta gcaaaatatt 411841 actatgaaca gaaatggttt aaactgtctg cttcctactt tctacaagtt gaagaggcaa 411901 gaaaacaaat acaaaggagt gaaggtttgt atgaaattga aatctaagtt gtttgttatt 411961 tgtttggccg cagccgcgat ttttacagcg gctggcgttt ctgctaatgc ggaagcactc 412021 gactttcatg tgacagaaag aggaatgacg taagaacaag ccccttctca ttagcgagaa 412081 ggggtttttc ttttcaaaaa aacaccgcaa gacatagtct tgcggtgccg ccttcatgga 412141 gattacgttt atttagtagc ctcctacaaa tgcagttccc acaatgatca agaggataaa 412201 taacacaaca atcaaagcga aagaagttcc gtaacctgac attttgtgca cctccttgcg 412261 agattgcttc agcaaatgct gcaaaactgt ggcggacagg gtcccgcaga gacggtcagc 412321 agcttagaag ccgccaacaa acgcagtccc tacgataatt aatagaataa acaatacaac 412381 gattaaagcg aaagaactga tgccgccgta accgccgccg ttagagtatc ctgacataag 412441 gtttcacctc cctatgaagg atactataag atatgctgaa ccgatccatt tggcagggat 412501 aatagtggac aagagaaaaa atgaagaatt cggctatatg aaggtgatat aaaaaaatag 412561 cgggcgctgc cgcccgctat ttatgtacga ttaagagatc agcacgcccg cgaaaaattc 412621 ctggtataac gcttgaacgg cttttctttc ttcggcttct tttacgccaa acatcatgct 412681 cacttcagaa gacccctgat tgatcatttc gatattcacc tgtgcctctg ataatgcttt 412741 ggcggctctt gccgttgtac cgacattgtg gcgcatcgct tcccctacaa ccataatcag 412801 ggcgagatga tgctcgacga tgacttcatc ggcatgcaaa tcctcttcga tccgtttgat 412861 gacgctgcgt tcagtggcgg catccatttg cccctgccgt aaaatgattg tcatgtcatc 412921 gattcccgat ggaacatgct catacgtcaa accatgctcc tccaggattt gaagggctct 412981 gcggccaaaa ccgatttctc tgttcatgag atacttgctg atataaatgc tgcaaaaacc 413041 ggtgtcgctg gcaatgccga cgacaggccc gtttgtgtta tcccgcttgc tgacgacgcg 413101 ggtgccttcg gctgaggggt tgttcgtatt tttgatctga acaggaatcc ccgctctgaa 413161 tgccggaatg agcgcttcat catgaaacac tgaaaaaccc gcgtaggaca gctcccgcat 413221 ctctctatat gtcagctcgc tgatttcctt tggattctca acgaaggacg gattgacaga 413281 atacacagcg tctacgtctg taaagttttc gtacaaatcg gcttgtagtc cgttggcaag 413341 aatcgaaccg gtaatatcag aaccgctccg tgagaatgtg atcacatcgc catccttgct 413401 gaatccgaaa aaaccgggaa aaatgatgag tccgtcacgt tcccgaagac gatagaggtt 413461 ttgataggat tcaggaagaa cttgcgcgtt gccgggttca tttgtcacaa agaggccggc 413521 atccttcggg tttacatatt ccgctttgac gcctttataa cggaagtaag cggcgatcag 413581 tttggcattg ttatcctctc cgctggcctt gactgcgtca aggtattgtt cgggattgct 413641 tttgtctcct tctaaaagcg taaacagatc atctctgatt ttttcgataa tgctttgccc 413701 cagctgaagc tcattggcga tgagagcgta ccgttccaca acagcttccg ccagttcagg 413761 tgcgctgcct gttgccaaat attgttctgc acatgcgatt aagagatcag tcactttcgt 413821 atcctcggca tagtgttttc ccggagctga aacgactaca gctttccgtg ccggatctga 413881 ggtaacgatg tgaaacacct tgtcaagctg ggcgcctgaa gcaagtgagc tgcctccgaa 413941 tttaacgacc ttcatgttta catctcctaa tgtttaaaat tttcacacaa atttagtatt 414001 tattatctct ctttcagtac tgtaaatcaa gggggaattt ctttctcagg agaacatttg 414061 tatttttcac gaggaataat gttaggtttg ctgaccgtat gcctgcgtta taaagataaa 414121 tatggtaaac agcctaacgt tttgggatgg aaaatggtta gaatgattag taaaattgat 414181 aaatgactag gttaatattt ttaaagaata ttgactaacc ctataaaaat ggtaatatgt 414241 aaatgataat gataatcaat tactatatgg ccatattgtt ttgagtcctt gcggagtagg 414301 agatacgttc tttttgctgt aaggatgtaa ggaggcagca tgaagctacg ttacttattt 414361 attctactta tcatattagc agtcacatct gtatttatcg gtgtagaaga tctgtcgccg 414421 cttgatctct tcgatttaag caaacaagag gcgtcaacgc tgtttgcaag ccgtttgccg 414481 cgattgatca gcattgtcat tgcgggatta agcatgagca tctgcggttt gattatgcag 414541 cagatcagca gaaataaatt cgtgtcaccg acgacggcgg gcacgatgga ttgggcgagg 414601 ctcggcattt taatttcctt gctgctgttt acatccgcca gtcctttaat caaaatgctg 414661 gtcgcgtttg tctttgccct tgcaggaaat tttctgttta tgaaaatcct tgaaagaatc 414721 aagtttaacg acaccatctt tattccgctt gtcggtttaa tgctcgggaa tatcgtcagt 414781 tcaatcgcga catttatcgc atataaatat gacttgatcc agaatgtgtc atcatggctg 414841 cagggagact tctctttagt cgtgaaagga agatacgagc ttctttatct gagtattccg 414901 ctcgtcatca ttgcctatgt gtatgcggat aaattcacat tggccggtat gggtgaaagc 414961 ttttctgtca acctcggcct caagtataaa cgggttgtga acatcgggct cattatcgtg 415021 tccctgatca cgtctcttgt cattttgact gtcggtatgc tgccgtttct cggtttaatc 415081 atcccgaata ttgtatcgat ttacagagga gacaatctga agagcagcct gccgcatact 415141 gtgctgttgg gagcggtttt tgtgctgttt tgcgatatac tgggcagaat cattatcttc 415201 ccttatgaaa tctcgattgg cctgatggtc ggaatcatcg gcagcggcat tttcctgttt 415261 atgctgttaa ggagaaaagc ctatgcgtaa ccagatgaaa atagctttgc tcgttggttt 415321 agccattgta tgtattggct tgtttttgtt ttatgactta ggcaattggg attacaccct 415381 gccgagacga atcaaaaaag tcgctgccat tgtgctgact gggggagcga ttgcgttttc 415441 gaccatgatc tttcaaacga ttacgaacaa ccgcatcctg acgccgagca ttttgggcct 415501 tgattctctc tacatgctga ttcagactgg cattatcttt ttgttcggtt ctgcgaatat 415561 ggtcatcatg aataaaaaca tcaactttat catctctgtt ctgctgatga tcctgttttc 415621 tcttgttttg tatcagatca tgttcaaggg tgaggggaga aatatctttt tccttctgct 415681 tatcggaatc gtgtttggca cgctgttcag cagcctgtct tcttttatgc agatgctgat 415741 tgatccgaac gagttccaag ttgtgcagga caagatgttt gccagcttta acaatatcaa 415801 tacggatttg ttatggctcg cgttcatcat cttcctgctg acaggcgttt atgtctggcg 415861 ttttacaaaa tttttcgatg tgctgtcgct cggacgcgag cacgccgtga atttgggcat 415921 tgactacgac aaagtggtga agcagatgct gatcgtggtt gcgattttgg tttctgtttc 415981 aacagcgcta gtcgggccga ttatgttttt aggccttctg gtcgtcaacc tggcgagaga 416041 attcctgaaa acatataagc attcatactt aatcgcaggc tccgttttca tcagcatcat 416101 tgcgctggtc ggagggcagt ttgtggttga gaaagtgttt accttctcaa cgacgctgag 416161 cgtcattatt aattttgccg gcgggattta ttttatctac ttgctgttaa aggagaataa 416221 atcatggtag aggtcagaaa tgtaagcaaa caatatggcg ggaaagttgt tcttgaagag 416281 acgtcagtca cgattcaaaa gggcaaaatc acctcgttta tcggtcctaa cggcgccggc 416341 aaaagtacgc tgctgtctat catgagccgc ctgatcaaaa aggattccgg cgagatttac 416401 atagacggac aagagattgg agcatgtgac agcaaagagc ttgccaagaa aatgagcatt 416461 ttgaagcagg cgaaccaaat caatatcagg ctcacgatca aagacctcgt cagttttggc 416521 aggtttccgt actcacaggg ccggctgaca gaggaagact gggttcatat caaccaggcg 416581 cttagctata tgaagctgga agacattcaa gacaaatact tggatcagct gagcggcgga 416641 cagtgccaaa gggcatttat cgccatggtc attgcccagg acacagatta tatctttctg 416701 gatgaaccgc tgaacaatct ggatatgaaa cactcagttg aaattatgaa actgctgaaa 416761 cggctggtag aggagcttgg aaaaacgatc gtgatcgtca ttcacgatat caattttgct 416821 tcagtctatt ctgactatat cgtcgctttg aaaaacggcc gaatcgttaa agaaggaccg 416881 cctgaagaaa tgatagaaac atcagtgctt gaggaaatct acgatatgac catcccgatt 416941 cagacgattg ataatcaaag aataggtgtt tatttttctt aatatataga agaggtgagg 417001 agcatgaaaa agttcgcgtt actattcatc gctttggtca ctgccgttgt catttctgca 417061 tgcggaaacc aaagcacaag cagcaaaggt tctgatacaa agaaagaaca aatcacagtg 417121 aaacaccagc tcgacaaaaa cggcacaaaa gtaccgaaga accctaaaaa agttgtcgta 417181 tttgactttg gaagcttaga tacattagat aaactaggac ttgatgatat agtagcgggc 417241 ctgccgaaac aagtccttcc taaatatctg tccaaattca aggatgacaa atacgctgat 417301 gtcggcagct taaaagagcc agacttcgac aaagtggcag aattagatcc tgatctgatc 417361 attatttcag caagacaatc tgagtcttac aaagaattct ctaaaattgc gccgacgatt 417421 taccttggtg tagatacagc gaagtacatg gaatcattta aatcagacgc tgaaacaatc 417481 ggtaaaatct ttgataaaga agacaaagtg aaagatgagc tcgcaaacat tgatcactca 417541 atcgcagatg taaagaaaac cgctgaaaag cttaacaaaa acggtctcgt catcatggcg 417601 aacgatggaa aaatcagcgc gttcggccct aaatcaagat acggcctgat ccatgacgta 417661 ttcggcgtgg ctccggctga tcaaaacatc aaagcgtcta cgcacggaca aagtgtttct 417721 tacgagtaca tttcaaaaac aaaccctgat tacttgtttg ttattgaccg cggtacagca 417781 atcggagaaa catcatctac aaaacaagtc gtggaaaacg attatgtgaa aaacgtaaac 417841 gcagtgaaaa atggtcatgt catctacctt gattctgcta cttggtattt atcaggaggc 417901 ggacttgagt ctatgacgca aatgattaaa gaagtgaaag acggtttaga aaagtaaaac 417961 caaaaagagc ctccgctaaa tagcggggct ctttttttgt taatcagcgt gccggctgct 418021 gttcggcagg gcgctgaggt ttctttaatg tgaatgagag aaggaagccg acaagtgcaa 418081 tgacggcagc cactataaaa gcggcgttca tgccgtgcag ggcggcgtgc ttcacatttg 418141 tcgtgcctgc atgtgccgcc tggttgctca tcacggaaac caatagtgcg gttccgatcg 418201 agccgccgac ttggcgaatc gtgttgttca tcgcagttcc gtgcggaatc aagtggcgcg 418261 gcagcgcatt gattccggct gttgtcaccg gcatcatgat catggcggtg cctaagagac 418321 gaacggtgta taaaacgaca atccaagcga gtgacgtatg gtcagtcagc tgcataaacg 418381 gcagagatgt caggaagatg atgcagaaac cggcaatcgc cagccctctt ccgccgacac 418441 ggtcaaaaat tctgccgata atcggcgaca taaagcccat cacaacggct cccggcagga 418501 gcataagccc tgtatcaaaa gctgtgacgt ctctgacatt ttgtgtataa agcggcagga 418561 tggtttccgt accgatcaat aatgcaaaga cgagggttcc cagcagtgtt gttaagctga 418621 aaacgccaaa cgtgaagacg cggaattcca gcatcggttt tttaagcttc atttgtcttg 418681 tgataaacaa gagcagcgcg atgacaccca ccagcagtga aatcaagacg gttgaactgg 418741 accagccata agagccgacg cttgagaagc cgtacagaag gccgccgaac ccaaatgttg 418801 aaaggatgac tgataaaata tcaatctgtg tttttcttaa agtcgtcacg tttttcatca 418861 ggatgctggc aagaatcaaa tcaatcacag caaacggaag aataatataa aacaatgatc 418921 tccaagagaa agcttcgaca gcccatccgg aaagagtcgg tccgatcgca ggcgcgaatg 418981 agatgaccaa tccgaccata cccatagcct ggccgcgctt ttcaatcgga aagattgtca 419041 ggaatacagt ctgcatgagc ggcatcataa tgccggctcc agccgcttga atgatacgcg 419101 ctgtcagcag aaccgggaag ttcggcgcga acgctccgac gactgttccg gcagtgaaaa 419161 tgctcattgc tgtgatgagc agcgcccggc ttgtgaattt ctcaattaaa aacgcggtaa 419221 tcggaattaa aatcccgttg gttaacataa atgatgttgt cagccattgt gcttggttgg 419281 catcgacatt gaaatccctc atgatatggg gaagtgcagt aatcaacaat gtctggttca 419341 aaatcgccac aaacgctccg gctaacaaaa tgccgacaat gacagaacgg ttaaaaggtt 419401 tttgttcaat acttgtgttc aatacatatc ccttcttttc tctaagtaat taacagtgtt 419461 tttaacatgg aaacgggctg tgttaaaaca ccggtttgtt ccagatagcc aatcagtgat 419521 ttgagtaaaa aagcgcgggg ttcttccttc ttcgcttctt cctccagcat agcggctgcg 419581 gatgtcagtt catctacgtc atagtccgcg gcggacaggg aagagatgcc tttatgtaat 419641 tccttcaggc tttccgataa taggactgat ttatcctttg gcttgtagga ggatgctgaa 419701 tgaatataaa gctcgatggc ttcgggcgga agaagagact ggcgggtttc cctgtttttg 419761 ataatctgat tgagggtgct gatgataaac tctgcgatcg ggtcaagctc aagcggtttt 419821 tcctcgattt tgatcagcat taaaaactca cgcatcatgc cgtgaagaat gataaccaaa 419881 tcccacacaa acgggagaat ggtttctcca tacgcctgga tcagcgaatc gcggtgccag 419941 cagataatcg tcgatctggt ctgatggata tgctgtttga cccggtcatt gtgcagcttg 420001 gggtttccgt aggtcagcat attgaaaaac tgctgattcc gcctgaagcc ctccagttcc 420061 attttgacct tttgcgtcaa acgctcctcc ggtgtaagtg ctgtattttc ctgaagtctt 420121 gaggccgcgg ccaccatttg cttctggtta aatgacagca gctccaaaag cagatcttct 420181 ttagattgga acagcttata tatcgaagct tttgacatct tacattcttc tgcgatcgcc 420241 tgcatggaaa ccgacgtaaa atccttttcc gaaaaaagct ttcgcgcggc taacaagata 420301 tctgtttttt tatcaagcat ctcatggctt ccttctttct tgaacattag aaaacccatt 420361 ggttcacaga aaaccaatga gtaacaatga aaaaatttta ccagataaac aaaatagaag 420421 tcaatggatt ttaaccgggt aaatgaaagg cctgccggaa aatccgacag gccgaataag 420481 agcttatttt tcaactttaa atccttgttt ttcaagcatt tcacggatgt gcggatagta 420541 caggcgctca tagtaggaag cgatgctctg tgaccagttt cttgtttctt ttccgtttgt 420601 ccgtttattc atgtattcag acatctgttc gtcgtatgcc tgaatgtgag acgtcagctc 420661 atcctgattc aaataagttt cctgatgatt gacagcttcc tgcggcaagc gcggtttttt 420721 cgctgaacgg tcggcaggat gcccaatgac aaggccggat aaagggaaca cgtatttcgg 420781 aagctcaagc agttcgatca gctcttgagg gtttccgcga actgcaccga tcggaactgt 420841 gccaagtccg agtgactcag ccgctgctgt tgctgtgccg agggcaatac cagcgtctac 420901 tgcgccgaca agaacagatt ccaatccatt tgtgatttcc attttgaaat catgcagatc 420961 ttcaagcgca attttggccc ggttaaaatc tgcgcagaac agcaggaaaa caggagcttg 421021 atcgatccat ggctggccgc ctgccagctc ggagattttc tttttgcgct ctttatcctg 421081 gactgtgatc acagtcactt gctgtccgtt gatagaagaa ggggctgatt gcaccgcttc 421141 aatgatttgg tccaattgct cctgagctac aggctcatct gtgtagctgc gaatcgagcg 421201 gtggtctgtt aaagatttaa tcacttcatt catatgagac acccttcctt tactcgctaa 421261 gctctgtgcg gacaacatca agaggagcgc tcagcagttc ttttcctttt gcgacaaacc 421321 cttggaaatg cgcagtttcg ttatggaatt tcattgccgc ttcatctttc catttttcaa 421381 gcatgacaaa tgtattttct tcgcctactt tttcgaatag gtcgtattgc gcgttgcctt 421441 cctcagctct tgaatgctga acaagtgatt gagcctcgct caaaaattcc tcgcgttttt 421501 ctggttttac tttgatgtaa gcttgtaata cgatcatgta aatctcctcc gtcgttatgc 421561 gaatttattg ttcgaatttc atcgaactaa atgtaacatg tattctaaat gaggtaaagg 421621 aaaaaccctt atatagtaaa attgtcattc taattgttgt atgatacatt tgtgtcatga 421681 acattccaaa ccatccagaa acagaaacat tgcagctgac aaaggttctt catgcactta 421741 gtgatccgct tcgtttagag ctcgtcaagc aattagctga agcaaaagaa aaaacgtgca 421801 gcacctgtgc agatgtgcag gttgccaaat cgactttgtc gcatcatttt aaagttttga 421861 gagaatcagg catcgctcaa gttcggatag aaggaaagcg ccggtattat tcgcttcgcg 421921 ctgaagacct tgaaaaggca tttccgggac tgcttgaagc cgtgctgaat gtagaccagg 421981 accgctggtg aatcaatccc ctgtaacggg gattttttta tgtccgtaaa ccgctttgaa 422041 aagccgctgc acaccctcct gaatatcttc ttccttcagc cgtgcaaagc cgataatgag 422101 agcaggcctg cccgtttgcc gcttgttttc cttcaagtta aatcggctca ttccgaatat 422161 ttcaagctgc agcccggcag catgtgacag gatgtcttgt tcggtgcgcc tggtatcaaa 422221 ttcggtaaca aaatgcagcc ccgcatttgc cccttttacg gtaacctctc cgctgaactc 422281 tgcttctaaa gcggtgatca ggcgttctct cttttcttta taatgctgct tcattttttt 422341 tatatgcttc tgatattcac cagactcgat aaattcctgc agggtgagct gtgtgagtga 422401 tgagcaagtc tgcagatcat agccccgctg tttgtatgcc ctcaacagct caggcggcaa 422461 caccatatag ctgatccgta agccggggag aagggacttt gaaaaggttc ccatatagat 422521 gacattttga aaacggtcga ggctttgcag cgccggaata ctgtctacat catatgtgaa 422581 ttcactatca taatcgtcct caatgatata tcggcgcggc tcctcggctg cccagttcag 422641 cagctgaatt cttctggata caggcataat cgttccggac ggaaactgat gcgacggggt 422701 ggtcaccagc acatctggct gctgtctggt gatttcagca atcgacatgc ctttttcatc 422761 cagcatgatc gtctttactt gttttccggc attcttcaaa agctgataca tgcgcctgta 422821 gccaggctcc tccatcgcat acacggcttc cttgggtaaa agctcagtca acagctgcat 422881 gagcacctgt gtgcctgccc ctatgatcat ttgttccggc ctgcatttta cacccctcgt 422941 cagggaaatg agcctcgtaa tggccgctct cacttcatat atcccttgcg gatgtgacat 423001 atcgccgagc gtgcggtatg agcgggaggc cgctttttgc tcgcagcgga accagctttt 423061 gatcggaaaa tggtctgtat cggaactcat gtgtgaaaac gatatccaat cgctctggtc 423121 gatgtgaatc tcttttaggt catccggcag tgcaaatgga gggtgctcct cggcggaaaa 423181 catgtctagt tcctccacga agaaaccctt tcgttcaatg gcgtacaaat acccctcagc 423241 cagcagctgc tgataggctg aattcactga atttacgctg accttgagat tttcagccag 423301 ctcccgcttg gagggaacct tcgagtgcgg cagcagattg cggctgagga tttctttttt 423361 cagcttttga taaatttgct gatagatata atcggcttgt tctgaacgat cgagtgtaat 423421 cgtgatatcc attttgtagt ttctccttct gataccatca aaaagttata attggtactt 423481 ttcatcatac caaagagaag tcagaatgat aagaaaatac cgacaggggg atattcacat 423541 gagtcaaaca acagcaagca tcacaactgc acaatggcag caaaaacggg atcaatttgt 423601 gtcaaaaggt gtgagcaacg gcaaccgcag tctggcggtc aaaggagaag gggccgagct 423661 gtacgatctg gatggccgga gatttattga ttttgcaggc gccatcggca cgttaaatgt 423721 cggacactcg catccgaagg tggttgaggc tgtgaagcgg caggcggagg agctgattca 423781 tcctggtttt aatgtcatga tgtacccgac ttatatcgaa ttagcagaaa aactgtgcgg 423841 catcgcgccg ggcagccatg agaaaaaagc gatttttctt aactcagggg cagaagcggt 423901 cgaaaacgct gtgaaaatcg ccagaaagta tacaaagcgc caaggcgttg tctcgtttac 423961 acgcgggttt cacgggcgca cgaatatgac gatgagcatg acaagcaagg taaaacctta 424021 taaattcggt ttcgggcctt ttgcgccaga ggtttatcaa gcgccgttcc cttattatta 424081 tcagaagccg gccggcatga gtgatgaaag ctatgacgat atggtcattc aagcattcaa 424141 tgatttcttt atcgcttcag tggcgcctga aacggtggcg tgtgtcgtga tggagccagt 424201 gcagggagaa ggcggattta ttattccttc gaaacggttc gtacagcacg tcgcttcatt 424261 ctgcaaagaa cacggcattg tttttgttgc tgatgaaatc caaaccggct ttgccagaac 424321 tggcacttat ttcgcaattg agcactttga tgtagtgccc gatctgatca cggtttctaa 424381 atcgcttgcg gcaggcctgc cattaagcgg tgtgatcggg cgtgcggaaa tgcttgatgc 424441 ggcagcgcca ggggagctgg gcggcacgta tgccggcagc ccgctcggct gcgcggcggc 424501 tttggcagtc ttggatatta tcgaagaaga aggactgaat gagcgatctg aagaaattgg 424561 caaaatcatt gaagacaagg cgtatgagtg gaaacaagaa ttcccgttca tcggtgacat 424621 ccgcagactc ggggcgatgg ccgcaatcga aatcgtcaag gatcctgaca cgcgtgagcc 424681 tgataagaca aaagcagcag cgatcgcggc ctatgcgaat caaaacggat tacttttgct 424741 gacagcggga attaacggta atatcatccg ctttttgaca ccgctcgtca tctcagacag 424801 cctattaaat gaagggctca gcatcttgga ggcgggcctg cgagcttaat cattggaaag 424861 aaaatggccg ggtctgctat cattttaagt aatcatgaaa agaaaggaat gttcaatatg 424921 ccagatcaat taacggtcta caacccggct acgggcgagg agatcaaaac gattcctcag 424981 caatcagcca cagaggtaga agaagccatt gaacgttcac atcaagcgtt taaaacgtgg 425041 tctaaaacat cagcgaacga aagaacgtct cttttgaaaa aatggtatga gctgattgtt 425101 gaacataaag aagagcttgc agatttaatt acaaaggaaa acggaaaacc ataccaggaa 425161 gcagtcggcg aggtacttta cggcgcaggc tatatcgaat ggttcgcaga ggaagcgaag 425221 cgtgtgtacg gaagaacggt cccggccccg acaactggta aacgaattgt tgtcacacgc 425281 cagccggtcg gccccgttgc tgctatcacg ccctggaatt tcccgaatgc gatgattaca 425341 cgcaaagcgg cgcctgctct tgccgccggc tgtacattta tcatcaagcc ggcgccggac 425401 acaccgctgt ctgcttatga actagcgcgc ctcgcatatg aagcgggcat tccgaaggat 425461 gttcttcagg ttgtgatcgg cgatggagaa gaaatcggaa atgtgttcac aagcagtccg 425521 aaaatccgca aaatcacgtt cacaggctca acacctgtag ggaaaatcct tatgaaaaac 425581 agcgctgaca ccgtaaagca cgtctcaatg gagctcggcg gacacgcccc gctgatcgta 425641 gatgaagatg cggacattga ccttgccgtt gaacaggcga tggcgtccaa ataccgaaac 425701 gccggccaaa cctgcgtatg tgccaaccgc ctgatcgttc atgaatccat taaagatgaa 425761 tttgctgcga aactgagcga gcaagtgtct aagctgaaag tcggaaatgg acttgaggaa 425821 ggcgtcaatg tcggcccgat tatcaacaaa cgaggcttcg aaaaaatcgt cagccaaata 425881 gatgatgcgg ttgaaaaagg cgcgaaagtg attgctgggg gcacatatga ccgaaacgat 425941 gacaaagggt gctactttgt gaatccgaca gtgctcaccg atgtcgatac gtccatgaac 426001 atcatgcatg aggaaacatt cggcccggtc gccccgatcg tcacgttttc tgatattgat 426061 gaagcgattc agcttgccaa cgatacaccg tatggcttgg ctgcttactt cttcacagaa 426121 aactaccgcc gcggcatcta tatttccgag aatctagagt atggcattat cggctggaat 426181 gacggcggac cgtcagcggt tcaagcgcca ttcggcggaa tgaaagaaag cggcatcggc 426241 cgtgaaggcg gttcagaagg tatcgagccg taccttgaaa caaaatattt gtccatcggt 426301 ttataaaaga atgcacgctc ctgagagctg ccggattttc cggcagctct ttttgtgttc 426361 cggcgaataa tcacaacaat tccagccaaa ataacagcaa atacattttg aaagaaggtt 426421 ccccaacaat ggatttatta ttggctcttc tcccggcttt gttttggggg agcattgttc 426481 tcttcaatgt gaaattaggc ggcgggccgt acagccagac actgggaacg acgatcgggg 426541 cactcattgt ttctatcgtt atttactttt ttgttcagcc cgttctgtcc cttcgcattt 426601 ttattgttgg aatcgtatcc ggcttatttt ggtcacttgg acaggccaac cagttgaaaa 426661 gcattcaatt gatgggcgtg tcgaaaacaa tgccgatttc cacaggaatg cagctcgttt 426721 ccacctcgct gttcggtgtg atcgtgttcc gcgaatggtc aacaccgatt gcgattacgc 426781 ttggcgttct cgctttgatc tttatcattg tgggaatcat tctcacgtcc ttggaagata 426841 agaatgataa aaaagagggc gagccaagca atttgaaaaa gggcattttg attctccttg 426901 tttcgactct tggttatttg gtttatgtag tcgtggctag attattcaat gtgtccggct 426961 ggtccgcgct gctgccacag gcaattggca tggtggtcgg ggggttagtt ttaacctata 427021 gacacaaacc ctttaacaag tatgcgatca gaaatattct cccagggtta atctgggcag 427081 gcggaaatat gtttttgttt atttctcagc cgcgagtcgg cgttgcaacg agcttttccc 427141 tttcacaaat gggaattgtc atttctacgc tcggcggtat tttcatcctg cgtgaaaaga 427201 aaacgaaacg ccagctaata gcaattgcga tcgggattat cctgattatt gccgccgccg 427261 tattcttagg aatcgccaaa acaaattcat aacaaatgga ggaggatgta tatgtatccg 427321 gatttaaaag gaaaagtcgt cgctattaca ggagctgctt cagggctcgg aaaggcgatg 427381 gccattcgct tcggcaagga gcaggcaaaa gtggttatca actattatag taataaacaa 427441 gatccgaacg aggtaaaaga agaggtcatc aaggcgggcg gtgaagctgt tgtcgtccaa 427501 ggagatgtca cgaaagagga agatgtaaaa aatatcgtgc aaacggcaat taaggagttc 427561 ggcacactcg atattatgat taataatgcc ggtcttgaaa atcctgtgcc atctcacgaa 427621 atgccgctca aggattggga taaagtcatc ggcacgaact taacgggtgc ctttttagga 427681 agccgtgaag cgattaaata tttcgtagaa aacgatatca agggaaatgt cattaacatg 427741 tccagtgtgc acgaagtgat tccttggccg ttatttgtcc actatgcggc aagtaaaggc 427801 gggataaagc tgatgacaga aacattagcg ttggaatacg cgccgaaggg cattcgcgtc 427861 aataatattg ggccaggtgc gatcaacacg ccaatcaatg ctgaaaaatt cgctgaccct 427921 aaacagaaag ctgatgtaga aagcatgatt ccaatgggat atatcggcga accggaggag 427981 atcgccgcag tagcagcctg gcttgcttcg aaggaagcca gctacgtcac aggcatcacg 428041 ttattcgcgg acggcggtat gacacaatat ccttcattcc aggcaggccg cggttaaaca 428101 taaaaagcga cccagacatg acatctggat cgctttcttt attaggcacg ctttttcttt 428161 acaagtgctg ctacagataa aataatggca gccgcagaca gcaccatcgc tgtaatgtct 428221 agagctgaag aacctgagtt ttcggaatcg tcttctgttt tcgtggcgcc gtgctcatct 428281 gtcacttgct ttgcagacgt gatgtttgta atggaatgag gtgtatcggc atcctcgtca 428341 cctgtccact caacaatgct gccgtctttg taatattggt atgcgtccca agcagcttcc 428401 tccgctttgt cagggttttt ggcaacaaag gtaaactgct ggaactggcc ttcctgaatg 428461 cctccgtcag tcgcctccca tgtcacggat actgatttgt catcatgttt ttgagtggaa 428521 accttccagc ccggaattgg ctcatattgc tggaattcaa catccttcgg cattttgagg 428581 acaaccttcg ttgtcggcag atttttctca gaaggaacct tcattgtata cgtttcccaa 428641 gagcctgcag cagactcagc cggttttaca gaaacatgcg cgctggcagg ggccgtaaag 428701 aataagaggg agccgacaat agccggacat agtgtcaatg cgattttttt caacaacgta 428761 aacactcctt aattggtctt tgtaaacatg atattgattt cgttaaagtc gccggtcagg 428821 ccgtggactt tgatcttcca gtttcctttt tcattaatcg acaggttttg atcttggaag 428881 acgccttttg ttttttcttt taatgtaaag gtgcttttgt tttcgctgcc tgacaggcct 428941 gttttataaa cggttaacgt gatttgctgg atgtttttca cgggatcacc gttatggtcg 429001 gtgacccgca gctcaaaaac attttttcca ggctggtttg ggctgatgct gagagaaacg 429061 ctttgtccgt tctctatcgc tttggtttgg tagaacggtt ccggcgctgg ctcaggcggg 429121 cttggcaggc ttgtaaacac ggccgctgtg atcaatacag cgatgccgat tgcccactcc 429181 gctttcaacg ttcggctgat tcctgtgcgg cgctgctttc tggtaagcag aaaatgaatt 429241 gcgcctaaga ccagcatgaa aacaaacagc ccgcttttca ctaaaagagc ttgtccgtac 429301 gctgtatgga acagtgaatc cattgaacga atgatgaaaa atccattgag caagcctgaa 429361 aacaaaatga cgccgactgc agtgagcgcc catggggaga accgtctgac cgtctcccac 429421 gcgagcgttt tgtcaggctg cctccattct tttgagagca gcaaaacgag tgccgctatt 429481 ccgccgaccc agatggaagc ggaagttaaa tgaaggaaat ccatcaaaat gccgaccgtt 429541 ttttcttcaa cgacagcagc atgcccggta aacgccttgg caagcaggag accgaaaaag 429601 aaaatgagcg gcgctgtcca atagccaaag gatgaaaagc ggtttttccg tatcgcaggg 429661 atgacagaca gtgcgagcag cacgaacagc gcagcctgta tgatccaaat ggagccgcct 429721 gctgtctcaa acagtgtttc tctgatgtag cccggctgga atgcgctgcc ccagccgccg 429781 cctgcgttcg cttttgtctg aatcggaagc tgaagcaaaa gcgccagccc caatgctgcg 429841 atcgagccgg tcaggatacg tctcgtccgt ttgacgagct gttctgattt ccctttatac 429901 cagaaaagat ggaagaaaac cgttccgata aacagagata aggctgtata cagaatcgcg 429961 cgatctgctg ctgttcccgg attcagcgct gaatcggctg ctttttggct gctgaatccg 430021 ccatccgctt tcccgatact gaacggaatg acgccggaaa caggatgtcc atccgcggat 430081 acggcattcc attccgctct gtacacatct ttaggcagat tcttcttcag cttcactgtc 430141 atgatgtgat gattatcttt tttgatttca gtcttgtccg tatccacacg gtcgccgttt 430201 gaattataga ctttaatgta atgaaaccct tcttcaaccg gttcattaaa ttcgatttcc 430261 acctgcgcag gggcgctttt taattcgctg ttttccccag gtgaagattt gacaatatag 430321 gcgtgagcaa agcttgtttt cggcaggaaa acaagaaaaa gcagaaggat gatccaccat 430381 ctgtttcgct tcatcactca gacaccacct tccgctgtat gtgttgtgtt atttcttggt 430441 gcaggtgcag cgtttctttc ggtcttgaag catgtcttcc agcgcttggt cgaaagtgca 430501 gacggctccg ccgaatcctt tttgaaatcg ttcggcatgg tcaagtgtcg caaacggaat 430561 ggcctgcggc tggcagcagt gcaggtttaa ttcagcattt acgacgaaat aagccgaacc 430621 ggcactgacg gttgtctgta acagaaaatc tctgcaaatc aagtgtgaaa cctcttccgt 430681 tttatccgcg taacgcaaaa acgcgcaatg tgcgcagcat agctgttcaa tgtcttggtt 430741 taccgtaatc agctgaaccg aatgagcttg attgacgggc ttcaagcaat agctgcacat 430801 atgatctgtt tgaggtgttc ggacggggag cgtgatgccg ccggccgttt taatgacctg 430861 atttgactga accagctgat tgacatctct atataccgtc atttccgaaa cgccgaacct 430921 tgcgctgatg tcagaaattc taagcgagcc ttcttctttc agccacttca gtatgtgttg 430981 ctgtctatta atcggaagca ttcatacacc ctcttcatta agatctattt aagcgtagag 431041 gattttagag acggagacaa gtaagtggat gataaaaaat gtgaaaatgt gttgaacagc 431101 aacaaaacga aacagaaggg actctggtat aatagacaga tggaatagaa agtgaggaat 431161 accctatgaa agaaacacca tgcccgaact gcggcaaacc tttgacaggc gatatggtca 431221 gatcatcaaa tgtgccttgt caatttcgct gcggccactg ccgggaacgg ctttatgaat 431281 ataaagtttc agctccgatt atgctggtat cattagcggc catcgtgctg cttatttatc 431341 ttttgatgct cctccgcaat gcggcaggct cagtgctgcc agctgtacag cacgtgccga 431401 tggctgtatt tgcgcttgtg tgcgcgtatc ccgtttttat tgtgagtgag cggatgattg 431461 caaagtacgt gattcaaaat ggcaacatca tttatagagg aaagagaaaa ggctcctgaa 431521 accaggagcc tttttatttt taaaaaattg tcacagtcat gtgccaaagt cctctttact 431581 ttcaattgta tagggactgt aagcgtttta acatagagtc aaagggaagc atcattctct 431641 gaacatattt ttgtatctta cagcgacaaa caaaacaggg agggtttata tatgcagcag 431701 caagaacagc agcaaggcgg catgaaagtg aaagtgcaac gctttgggag ttatttgagc 431761 ggaatgatca tgccgaatat cggcgcgttt atcgcgtggg gtatcattac cgcgctgttt 431821 attccggcag gatggtttcc gaatgaacag ctgaacacgc tggtcagccc gatgattacg 431881 tatttattgc cgcttttgat agcgtataca ggcggaaaaa tgatctacga ccaccgcggc 431941 ggagttgtcg gagcgacagc ggcaattggg gtgattgtag gatcggatat tccaatgttt 432001 ttaggcgcaa tgattatggg tccgcttggc ggatacctca ttaaacagac tgataaatta 432061 ttcaaggata aagtcaagca aggctttgaa atgctgatca acaactttac ggcagggatt 432121 gtcggcgcgg ctttaacgat tctcgcgttt tacgccatcg gcccggttgt cttgacgcta 432181 aataaattgc tggcggctgg tgtggaagtc attgtacacg ctaatttact gccggtagcc 432241 agtgtttttg tagaaccggc gaaagtgttg ttccttaaca acgccataaa ccatggaatc 432301 ttaagcccga tcggaatcga gcaagcatct caaacaggaa aatcaattct gtttttagta 432361 gaagcaaacc ctggaccggg gctcggcatt ttgctggcct acatgttctt tggcaaagga 432421 tcttcaaaat caacggctcc cggtgcggcg atcatccatt tcttcggagg gattcacgag 432481 atttacttcc cgtacattct gatgaaaccg gccctgattc tcgcagccat tgccggcgga 432541 gcaagcggac tcttaacatt tacgatcttt aatgccggac ttgtcgcggc agcgtcaccg 432601 ggaagcatta tcgcattgat ggcaatgacg ccaagaggag gctatttcgg cgtattggcg 432661 ggtgtattgg tcgctgcagc tgtatcgttc atcgtttcag cagtgatcct gaaatcctct 432721 aaagctagtg aagaagacct ggctgccgca acagaaaaaa tgcagtccat gaaggggaag 432781 aaaagccaag cagcagctgc tttagaggcg gaacaagcca aagcagaaga agcgtctgag 432841 ctgtctcctg aaagcgtgaa caaaattatc tttgcgtgtg atgcgggaat gggatcaagt 432901 gccatggggg catccatctt aagaaacaaa gtgaaaaaag cggagcttga catcagtgtg 432961 accaacacgg ccattaacaa tctgccaagc gatgcggata ttgtcatcac ccacaaagat 433021 ttaacagacc gcgcgaaagc aaagctgccg aacgcgacgc acatatcagt ggataacttc 433081 ttaaacagcc cgaaatacga cgagctgatt gaaaagctga aaaagtaatc ttatagaaag 433141 agagtgattg tcatgcaagt actcgcaaag gaaaacatta aactcaatca aacggtatca 433201 tcaaaagaag aggctatcaa attggcaggc cagacgctga ttgacaacgg ctacgtgaca 433261 gaggattaca ttagcaaaat gtttgaacgt gaagaaacgt cttctacgtt tatggggaat 433321 ttcattgcca ttccacacgg cacagaagaa gcgaaaagcg aggtgcttca ctcaggaatt 433381 tcaatcatac agattccaga gggcgttgag tacggagaag gcaacacggc aaaagtggta 433441 ttcggcattg cgggtaaaaa taatgagcat ttagacattt tgtctaacat cgccattatc 433501 tgttcagaag aagaaaacat tgaacgcctg atctccgcta aaagcgaaga agatttgatc 433561 gccattttca acgaggtgaa ctgacatgat cgccttacat ttcggtgcgg gaaatatcgg 433621 gagaggattt atcggcgcgc tgcttcacca ctccggctat gatgtggtgt ttgcggatgt 433681 gaacgaaacg atggtcagcc tcctcaatga aaaaaaagaa tacacagtgg aactggcgga 433741 agagggacgt tcatcggaga tcattggccc ggtgagcgct attaacagcg gcagtcagac 433801 cgaggagctg taccggctga tgaatgaggc ggcgctcatc acaacagctg tcggcccgaa 433861 tgtgctgaag ctgattgccc cgtctatcgc agaaggttta agacgaagaa atactgcaaa 433921 cacactgaat atcattgcct gcgaaaatat gattggcgga agcagcttct taaagaaaga 433981 aatatacagc catttaacgg aagcagagca gaaatccgtc agtgaaacgg taggttttcc 434041 gaattctgcc gttgaccgga tcgtcccgat tcagcatcat gaagacccgc tgaaagtatc 434101 ggttgaacca tttttcgaat gggtcattga tgaatcaggc tttaaaggga aaacaccagt 434161 cataaacggc gcactgtttg ttgatgattt aacgccgtac atcgaacgga agctgtttac 434221 ggtcaatacc ggacacgcgg tcacagcgta tgtcggctat cagcgcggac tcaaaacggt 434281 caaagaagca attgatcatc cggaaatccg ccgtgttgtt cattcggcgc tgcttgaaac 434341 tggtgactat ctcgtcaaat cgtatggctt taagcaaact gaacacgaac aatatatcaa 434401 aaaaatcatc ggtcgctttg aaaatccttt catttcggac gatgtgaccc gcgtagcgag 434461 gtcacctctc agaaaactgg gagaaaatga tagacttgta ggcccggcaa agaaaataaa 434521 agaaccgaat gcactggctg aaggaattgc cgcagcactg cgcttcgatt tcaccggtga 434581 ccctgaagcg gttgaactgc aagcgctgat cgaagaaaaa ggatacagcg gcgtacttca 434641 agaggtgtgc ggcattcagt cccatgaacc gttgcacgcc atcattttaa agaaacttaa 434701 tcaataaccg accacccgtg acacaatgtc acgggctttt tttactatct cgcaatctag 434761 tataatagaa agcgcttacg ataacagggg aaggagaatg acgatgaaac aatttgagat 434821 tgcggcaata ccgggagacg gagtaggaaa agaggttgta gcggctgctg agaaagtgct 434881 tcatacagcg gctgaggtac acggaggttt gtcattctca ttcacagctt ttccatggag 434941 ctgtgattat tacttggagc acggcaaaat gatgcccgaa gatggaatac atacgcttac 435001 tcaatttgaa gcagtttttt tgggagctgt cggaaatccg aagctggttc ccgatcatat 435061 atcgttatgg gggctgctgc tgaaaatccg gagggagctt gagctttcca ttaatatgag 435121 acccgccaaa caaatggcag gcattacgtc gccgcttctg catccaaatg attttgactt 435181 cgtggtgatt cgcgagaaca gtgaaggtga atacagtgaa gttggcgggc gcattcacag 435241 aggcgatgat gaaatcgcca tccagaatgc cgtgtttacg agaaaagcga cagaacgtgt 435301 catgcgcttt gccttcgaat tggcgaaaaa acggcgcagc catgtgacaa gcgccacaaa 435361 gtctaacggc atttatcacg cgatgccgtt ttgggatgaa gtctttcagc agacagccgc 435421 tgattatagc ggaatcgaaa catcatctca gcatattgat gcgctggccg ctttttttgt 435481 gacgcgtccg gaaacgtttg atgtcattgt ggcgagcaac ttgttcggtg atattttaac 435541 cgacatcagc tcaagcctga tgggaagcat cggcattgcg ccttctgcga acatcaatcc 435601 atccggcaaa tatccgtcca tgtttgaacc ggttcacggc tcagctcctg acattgccgg 435661 acagggcctt gccaatccga tcggccagat ttggacagcg aagctgatgc tcgaccactt 435721 cggagaggaa gaattggggg cgaaaattct ggatgtaatg gagcaagtga ctgccgacgg 435781 catcaaaaca cgcgacattg ggggacaaag cacaacggct gaggtcactg atgaaatctg 435841 ttcgcgctta agaaagctct gatgaatcag gccggtggca gatggctgcc ccggcctgtc 435901 catttcctta cgaaaatttc cacgaaagtc taaccaagca gatccaaatg ctgtataata 435961 atttggaatt cttaggaaag catcgggtga aggaagttga atgcaaaaac aatcacgtta 436021 aagaaaaaaa gaaaaatcaa aacgatcgtt gtactcagta tcattatgat cgcagctctc 436081 atttttacga tcagattggt gttttacaag ccttttctta ttgaaggatc atcaatggcc 436141 ccaacgctta aagactcaga aagaattctg gttgataaag cagtcaaatg gactggcggg 436201 tttcacagag gagacatcat agtcattcat gacaaaaaga gcggccgctc atttgtcaaa 436261 cgtttaatcg gtttgcctgg tgacagcatt aaaatgaaaa atgatcagct atacataaat 436321 gataaaaagg tggaagaacc atacttaaag gaatataaac aggaggtcaa agagtcgggt 436381 gtaaccttaa caggtgactt cgaagttgag gttccttccg gtaaatattt tgtgatggga 436441 gataaccgtc tcaattcact ggatagcaga aacggaatgg gcatgccttc tgaggacgat 436501 atcatcggta ctgaatctct cgtcttttat ccattcggtg agatgagaca ggcaaaataa 436561 aatgcaatgc aaaaagaaca tggaacatga cggcaccgat aataaagcgc cgtgcacgtt 436621 taaaaaaatg atgatgaaac ggtgcggagc cggctttccg ccccgttttt tatgatagaa 436681 agcgttttga agaaaagggc cctgttgaaa taaacagaat caggattggc gaagccgtga 436741 agcgcatcga attggtaaat ctcaagatgg gtatgctgtt tttcccgcag ttttttgata 436801 agaagcgcta cgtcaaacga cggctcataa ttagggaaaa acaataggac cgggcaggct 436861 ggcatgtgat gaagagagtc gcgtatccgg gaaccgtaat aacaaaccga tccgctcacc 436921 tcaggcatac tgctgcattt ccatgcgata gtagccccca cgctgaatcc aatcacaaag 436981 atgtgccgtc cggcgttttg cctgatcaca ttctggatga tggtttctcc cgttttcagc 437041 ctttcgtgtt ttgtaaattg ttcgtatgcc gttttttctt ctttcagtgt gtagacttca 437101 tcctcgccga gcaggttggg cgtcaacaca tcatatccag ccattttgat cagccggccc 437161 atctttttca tatggctgtt tacaccatat atttcgtgtg cgagaatgac aagcggtttt 437221 gggaacataa cggcctcctt ttgtgttttt tccattatat cctatcgttt cactttaggc 437281 tgagatataa tggtcaaaaa aaggagatat aaaatgaact cattatcttt gcctcaccgc 437341 tatccatttt tgtttattga tggcgtgacg gatagcgagc ccggcaaaca tgcggcagct 437401 tataagctga ttagtgagaa cgactggttt atcactgata cgcaaacaga aatgccgttt 437461 tcacttgtga ttgaagcgct tgcgcaaacc gcggctttta caggaattac agatgagaac 437521 agcttgggat tattgtcttc ggtgaagaaa gcggaaaagc tgggagaagc tgtgcctggt 437581 gaccggcttg atcttacgtt tgaagtcacg cgcaatcggc gcgggtttgt gttcggacat 437641 gccaaggcat cagttggaga gcagcctgtt gctgaagctg aaatcggcat ctatattgaa 437701 aaatgaaaaa aacccttcac aacattttgt gaggggttct attttgtgtc gtaatcccgt 437761 tcgctttgag agttatctct ttgctggcgt ttgtgttttt catcattcat attttccttc 437821 agctcttcat taggaatcgg atcggttaag tcgttgtgct cggggttttc atttggtttg 437881 ttttgctgtt ttttttctgt catgtttgat cacctcaccg tttgttttcc tcttattcat 437941 tctcctcaaa cataggaaat cgcttttttg tcccgctggg tataatgtat tagaatagag 438001 agaagcacaa caaaaagata aagagaggta catatatgtc tgttcaaaga gaagatgtag 438061 atatcaagct gatcgcaatt gatatggatg gtacactgct gaacgacgag cagctgatct 438121 cggatgaaaa ccgcaaagcc attcgtgaag cggaggataa aggtgtgtat gtggtgatca 438181 gcacgggccg gacgctgatg acgtgcaggg agctggcgga atcgctaaag ctgtcatcct 438241 ttctaatcac ggcaaacggc agtgaaattt gggattcgaa ttttaatttg gtggaacgga 438301 agctgcttca tacggaccat attcaaatga tgtgggattt gcggaataag cacaacacta 438361 atttctgggc ttctacggtg aataaagtat ggagaggcga gtttccggaa aacattacgg 438421 atcatgaatg gctcaaattc ggctttgaca tcgaggatga cgatatccga aacgaagtgc 438481 ttgaggagct gagaaaaaac aaagagctcg aaatcacaaa ttcaagtccg acaaacattg 438541 aagtcaacgc gcttggcatc aacaaagctg cagcccttgc caaggttacg gaaaaactcg 438601 gctttacaat ggagaatgtg atggcgatgg gcgacagcct taatgacatt gcgatgatca 438661 aagaagcggg tcttggcgtc gcaatgggca atgcgcaaga catcgtaaaa gaaacggctg 438721 attatatcac ggatacaaat attgaggatg gtgtcgctaa agcgattcgc cattgggtac 438781 tataaaaaaa gagagtccta agatggactc tcttttttag tttggcaggt tttattctgg 438841 gaccatggta ggttttctga caaaagtatt tcacaaactg atatgattca cttataatga 438901 aataaagttc aaaaattcgg aatagtcgtt ccgaatttcg ggacaataaa tgacataaag 438961 catatcgttt gctttggcag gagggattct gtgtttcaga ttgatttaaa ctgtgattta 439021 ggagaaagct tcggagccta caagataggc cttgaccaag atattttaga gtatgtgaca 439081 tcagcgaata tcgcatgcgg atttcatgca ggagatccta gtgttatgcg aaaaaccgtc 439141 gcgcttgcag cagaaagagg cgtgaaaatg ggtgcgcatc cgggcttgcc ggatttactc 439201 ggttttgggc gccgcaatat ggcgatttct cctgaggaag cgtatgatct tgtcgtttat 439261 caaattggcg cgctctctgg ctttctaaaa gcagagggac ttcacatgca gcacgtcaag 439321 ccgcatggcg ctttatacaa tatggcggca gtcgatcaaa aactgtcgga tgctatcgcg 439381 aaagctgtct ataaggttga tcccggcctg attcttttcg gtcttgctga gagcgagctt 439441 gtaaaagcgg gagaacggat cggacttcag accgcaaatg aagtgttcgc cgacagaaca 439501 taccaatcgg acggcacgct gacaccgcgc tcccagccgg acgcactcat tgaaagtgat 439561 gatgccgccg tcacccaggt catcaaaatg gtgaaagaag gggcggtcaa atctcagcaa 439621 ggacatgatg tgtcattaaa agcagataca gtctgcattc atggagatgg agcccatgcg 439681 ctgacatttg cgcaaaaaat cagaaaacag ctcaaagcgg ctggaattga agtgacagct 439741 atttcagaac agaggtcaac ataaaggagg aacaatagat ggagcagcag aaaaagacag 439801 caggaaaaaa agcgggcagc tggtcattgc tgatgggcgc cgccttttta atggcgacat 439861 cagcaatcgg accgggtttc ctcacccaaa ccgcaacatt cacaaacaca ctcgcagcaa 439921 gcttcggttt tgtcatctta atctctatta ttttagatat tttcgcccaa accaatgtgt 439981 ggcgcatcat cgcagtttct ggaaaacgag gtcaggaaat tgcgaatatg gtgcttcccg 440041 gactggggta tttcatcgcc attctcgtcg tgcttggcgg actagctttt aatattggga 440101 atatcggagg ggccgggctg ggacttcagg tgctgttcgg cattacacct gaaacaggcg 440161 ctttaatcag tgccgttatc gccattttga tttttgtcat caaggaagca ggaaaagcga 440221 tggaccgttt tacgcaaatc gcggggttcg tgatgattat tttaacggtc tacgttgcgg 440281 cgacgacagc tcctccggtc ggacaggcag tcgcaaatac attcgtcccg gaacacatca 440341 gcatatttgc cattgtcacc ctagtgggcg gaaccgtcgg cggttatatc acatttgccg 440401 gaggacaccg tttgcttgat gccggaatta aaggaaagga atccattccg caggtgacaa 440461 agagctcggt tgtcggcatt ttaattacat ctgtcatgcg tatcgctctt tttcttgcgg 440521 ttctaggcgt tgtatcgaaa ggcctgcaca tcgatgaaag caacccggcg gcttctgtct 440581 tcaagctggc tgctggaaat gtcggttata aaattttcgg attgatcatg tggtctgcgg 440641 cgattacgtc tgttattgga gcagcctata catctgtttc attttttaaa accttttctc 440701 caaaaattga aaagaattca cgcggtatta ttatcggatt tattgtggtt tctacgttag 440761 cttttgtcac aatcggccag cctgcgaaga tcctcgtcct tgtcggttca ctgaacggct 440821 taattctgcc gattgcgctc ggaacgctgc ttgttgccgc ctacaagaaa aacattgtcg 440881 gtgattataa gcatccgctt tggctgacaa gcacaggcgc gcttgtagtg attgtaatgg 440941 cagttatggg aatctacacg ttatgtacac aacttcctca attgtggagc tgatataagt 441001 ggagcaatta aacaaaatgg cgccaaagga tgtacgcgcc ctgatacgag aggggaaaat 441061 aaacgggccg accgcaggca tgtccggcgg ctacgcccaa gcgaatcttg tggttttgaa 441121 aaaggacctt gcgtttgatt ttctgctgtt ttgccagcga aatcaaaagc cctgccccgt 441181 gctggatgtg actgaagcag gttcgcctgt gccgtctctg gctgcgccgg atgctgatat 441241 cagaacggac tttccgaaat accgtattta caggcacggt atcctaacgg aagaagtatc 441301 tgatattacg ccatactggg aggacgattt tgtcggcttt ctgatcggat gcagtttctc 441361 ctttgaacag gcactgatca ataatgggat agctgtccgg catattgatg aggggacaaa 441421 cgtctcaatg tataaaacga atatcgattg tgttccggcg ggggcgtttc acggacagat 441481 ggttgtcagc atgaggccgg ttcctgaacg gctggctgta cgtgctgcac aagtgacctc 441541 gcgttttccg gctgtgcacg gagggccgat ccatattggc aatccgggag caatcgggat 441601 tcgcgatctc gggaaaccgg atttcggaga tgccgtttcc attcgtgacg gcgaggttcc 441661 tgttttttgg gcatgcggag tgaccccgca agccgtggct atgaatgtaa agcctgaaat 441721 ggtcatcaca catgcgccgg ggcatatgct catcacagat attcgagacg agtcgcttgc 441781 ggtgctgtag cctctcgtca tcctgatgaa cgagaattaa aagaggtgag aaagatgact 441841 gtacgatatc aaatcgaaca gctcggtgat tctgcaatga tgatccgatt cggagaagaa 441901 atcaatgaac aggtcaacgg cattgtccat gcagcggccg cttatataga agaacagcca 441961 tttccgggat tcattgaatg tatcccggct tttacaagtc taaccgtatt ttatgatatg 442021 tatgaagtgt acaagcattt gcctcaaggc ataagctcac cttttgagag tgtcaagcgc 442081 gatgtcgaag agcggctggc agaaatagcc gaagactatg aggtcaaccg ccgtattgta 442141 gaaattcccg tttgctatgg cggtgaattc ggtccggatt tagaagaggt ggcgaagatc 442201 aatcaactgt caccggagga agtaatcgac attcatacaa acggtgaata tgtggtgtat 442261 atgcttggct tcgcgcccgg ttttcctttt ctaggcggga tgtcaaaacg cattgcagct 442321 ccgagaaaat catcgccaag accgtcgatt cccgcaggtt cggtcggtat tgcgggattg 442381 cagacaggcg tttatccgat ttcaacgccg ggcggctggc agctgatcgg caaaacgccg 442441 ctggctcttt tccggccgca ggaaaacccg ccgacattgc tgcgggcggg agatattgtg 442501 aaattcgttc gcatctcaga aaaagactat cacgcctata aggaggagtc caattgagca 442561 tgaaagtatt aaagcccgga ctgctcacaa cggttcagga tataggcaga acgggttacc 442621 aaaaatacgg cgttctggcc agcggcgcta tggacacggt ttcactgcgc attgccaatc 442681 tgttgatagg aaacggcgaa aatgaagcag gtctcgaaat aacgatgatg gggcccggtc 442741 cgtcgtttca tttttcaaaa cagacactga ttgctgtgac aggggcggac ttcacgctgc 442801 gtattaatga cgaggaagcg cctttatgga agcctgtgct catcaaggaa aacagcacgg 442861 tcagctttgg cccctgcaaa ctcggcagcc gtgcttattt ggcggcagct ggcggcattg 442921 aggtgcctgc cgtcatggaa agtaaaagca catacgtcag aggaagcatt ggcggacttc 442981 atggcagagc gcttcaaaaa gaagatgaac tgaacattgg agagatgtca gctctttcgc 443041 aaaccatcct ttctcgctta agttcgcagc ttggaaaaca gggatttgca gcaccgaagt 443101 ggtcagtcag ccgcggcaga tttctgccat tgaagaagaa tcccgtcatt cgggtgctgg 443161 aaggaaagca atttgccttt ttcacagaag aatcaaaaac gcgtttttat gaagaagcat 443221 ttcgtgtcac gccgcagtcc gaccgtatgg gctacaggct caaaggagaa ccgctcgaac 443281 tgaaggcccc gcttgagatg gtgtcggaag cggtttcatt cggaacagtt caggtgccgc 443341 ctgacggcaa cccgattatc ctgcttgcag accggcagac gactggcggc tatccgagga 443401 tcgcgcacat catatccgct gatcttccga ttgtttccca aatcatgccg ggcgagcacg 443461 ttcagtttga gcctgtgtcc ctccaggagg cagaagcgct tgcggtagaa cgggaacagc 443521 atataaaaga actgaaaacg agaatgaaga tggaatggct gacatagcaa aggggatgaa 443581 tgatgcagaa taaaaataaa accgtagtca aatctatggc gctgcttaat ttgtttttgc 443641 ataaaccaag cctaacctta agtgaactgg tgtcgctgac gggaatgccg aagacctctg 443701 ttcaccggat ggtcagctcc ttggaggaaa tggggttcct cagtcgggat gcgtccggcg 443761 cttattcgct gggattggtg tttttggaat tcggacagct tgtcgctgac aggctggata 443821 tcagaaaaat agcgaaaccg gtgatggaag agctgtgccg ggaagtggat gaggccgtgc 443881 agttgatcat gagggacggc aatgaagcga tatacgttga gaaaatagaa gggacacaga 443941 ctgtgcggct gtatacggcg atcggcaggc gttcccccct atacgcggga gcgtgcgcca 444001 gaagcattct gtcctttctt ccccgtgaag aaatcgaagc atacatcaaa caaaccgagc 444061 tcatttcgat tggctccgga acgattaccg atcccgaaaa actgcttcag gagattgatg 444121 cctctgtgca aaatggctat actgtcagct attcagagct cgaaaactat acggcggcga 444181 tcggcgcccc gatctttaac catgagcgcc aggtggcagc cggcattagc attgcaggct 444241 ttgaagcgag atttacagaa gacaggctgc cctatttaac agaaaaggtg aaggacgccg 444301 ctttacagat ttcaagaaaa ataggatata cataagtagc caatcttttc tctgctgcgt 444361 acattaacgt atcgacgttc aagagtggag gaaagaacat ggtgcttcga tatacagctc 444421 tgggcgattc cttgacgaca gggagaggct ccgggctgtt ttcacccggc ttcgtccagc 444481 gttttgggga catgatggaa gctgacttga aaacaagaac ggcaataaac atatttgcca 444541 gatcaggtct gaatacagaa gagattttgg gactcctgtc atatccctat gtgcaaaaat 444601 gtattcgaga tgctgatatg ataacgatca cagggtgcgg aaacgatctc atcgattcgg 444661 tcttagccta ccaaacctct aaggatgaaa cgattttcag ccgtgtatcc gcccattgcc 444721 atgagaattt tgaaaagatg attgccaaag tcgccgagat taaaggagaa aatccttccc 444781 cgtacgccat tcgtgtgttc aacttataca atccgtttcc cgaaattgat atcgccggca 444841 aatggatcac ttcgtttaat tcacatttag aaacacttgc atcagcaccc catgtcaaaa 444901 tcgcggatgc ctatagcatc ttcaaaggca aagaacagga atatctgtcc tttgacggtg 444961 tccatccgaa cagcaaaggc tatcaagcga tggctgaagc cgttcacaag ctaggctata 445021 aagaattatc agtttcatag aaaacgcgcc tcatgacagg cgcgtttttt atgtgtgatc 445081 gaaatattaa aagaaactta aaattctctg tcttctgttc tacagacaaa caaagtgcgc 445141 tagaataatg gagggcgtag gcaaatatag ccataacgtt caatatttcg tatataagga 445201 aggatggtcc ttttgtttcg gatttttaaa atgtcttttg cggttatcat tattatactg 445261 gcgcttattg cttttaacta tacggaacac acctctgtaa tccaatcggt catgctcgtc 445321 tttcttggtg cggtcatgtt tatgcagggg cttgaagagc gcaaaaaaga aaatgacggc 445381 tcaggcgctt ttaatattta taccgccgtt tttgtatggt ctgtctccct tatcggtttt 445441 acacttcata ttatataaat ctattacaca tcctgaaaat gctcgaccgt cgggaacggg 445501 gtatagaacc gatgaagcaa ggctttccac tcttgatact ctgaagaacc gcgaaagcct 445561 tccgtatggt cctcaagtgt ttcccactcc acaagaagca gatatttatg cgtttcctcc 445621 atgcattttg ataacgagtg agtgatatag cccttcatgc cggaaataat cggcgcagct 445681 tgccggaatg catcctcaaa ctcttgttca aggccttctt taatgtgaag cattgctgcc 445741 tctctgacca tgctatccct tctttctgtc ttttcaaata gtctacagca aacgatagga 445801 gatttctgca aaatcggtga acttttcctt cattttcaaa aaaatcttgc acgcaccaat 445861 tcaattaaga gaaaataaca agtggaaggc aggggaaagt catgttaaaa aagtgtattc 445921 tactagtatt tctatgcgtc ggattgattg ggttaatcgg atgctccaaa acagattcac 445981 cagaggatcg catggaagca ttcgtgaaac agtggaacga tcagcaattc gatgacatgt 446041 atcaaagcct gactaaagat gtcaaaaaag aaatctccaa aaaagatttc gtcaacaggt 446101 ataaagccat ctatgagcag gccggcgtaa aaaatttgaa agtcactgcg ggagaagtag 446161 ataaggacga tcaagacaac aagacgatga aacatatccc gtataaagtc agcatgaaca 446221 caaatgccgg caaagtcagc ttcaagaata ctgctgtgct gaaattagaa aaaacagatg 446281 acgaggagtc atggaatata gattgggacc catcgtttat tttcaagcag ctggctgacg 446341 acaaaaccgt gcaaattatg agcattgaac cgaaacgagg ccaaatttac gataaaaatg 446401 gaaaaggctt agccgtcaat acagatgttc cggaaattgg aattgttccc ggagagcttg 446461 gcgataaaaa agagaaagtc ataaaagaac tcgccaaaaa acttgatttg actgaagacg 446521 acatcaagaa aaagctggat caaggctggg taaaagacga ttcgtttgtg ccgctcaaaa 446581 aggtcaagcc tgaccaggag aaattagttt ctgaagcgac gtcattacaa ggcgtaacaa 446641 gaacgaatgt cagctcccgc tactatccgt atggcgaaaa gacagcccat ttgacaggct 446701 atgtccgcgc cattacagcg gaagaactga agaaaaagaa agaaggaacg tacagcgata 446761 cgtctaacat cggtatcgcc ggacttgaaa atgtgtatga agacaagcta agaggcacaa 446821 ctggctggaa aatctacgtg ccgcaaaccg gggaagtcat cgctgaaaag aaagcaaagg 446881 acggcgagga tcttcacctc acaattgata tcaaaacgca aatgaagctg tatgatgaac 446941 tgaaggatga cagcggggcg gcagtcgcgc tgcagccgaa gacaggcgaa acactcgccc 447001 ttgtcagcgc gccttcctac gatccaaacg gatttatttt cggctggagc gataaggaat 447061 ggaaaaagct aaacaaagat aaaaacaatc cgttttcagc gaaattcaat aagacatacg 447121 cgccaggttc taccattaaa ccgattgcgg ctgctattgg aatcaaaaac ggcaccctta 447181 aagccgatga gaagaaaaca atcaaaggca aggagtggca aaaagattca agctggggcg 447241 gctattcagt gacacgtgtg tctgagagac ttcaacaagt cgatttggaa aacgccctta 447301 ttacgtcaga caatatttat tttgcccaga atgcgcttga tatgggagcg gacaccttta 447361 caaaaggctt gaagacattc ggtttttcag aggacgttcc gtacgaattc ccgatccaga 447421 aatcgtctat tgcaaatgac aagcttgatt cagacatttt gcttgcggat acaggctacg 447481 gacaagggca aatgcaaatg tctccgcttc acttggcaac tgcttacacg ccatttgttg 447541 acaatggaga ccttgtcaaa ccgacgctga tcaaaaaaga ttcacaaaca gctgatgttt 447601 ggcacaagca agtggtcacg aaggaaggag cggcagacat tacaaaaggt ctgaaaggcg 447661 ttgtggaaga tgagcgcgga tcagcgtatc agcctgtcgt gaaaggaatc acagtggctg 447721 gaaaaacagg aacagccgag ctgaaaacat caaaagatga taaagacggc acggaaaatg 447781 gctggtttgt cggctacgat tacgaaaaca aagacctgct tgtcgccatg atgatccaaa 447841 atgtgcagga ccgcggcggc agccactatg tcgttgagaa agcgaaaaag caatttcaat 447901 cgaattaaaa tgtcttttta aaaggagcga aaggaaaaag gggatctgag gccgaatgaa 447961 ctagtaaggg ggcaaaaccc ggtttataca aagaaaagag ggattttgca tgcagcgtat 448021 tcaattggcg gaggatcttc aattttcaag agtcatacac gggctttggc ggctgaatga 448081 atggaactat tcagatgctg aacttctaag cctcattgaa tggtgtatcg atcacggcat 448141 cacgaccttt gatcatgcgg atatttatgg aggctatacg tgcgaaaagc tgtttggaaa 448201 cgcccttgcc ctttcgcctg gattaagaga aaacatagag ttggtcacaa aatgcggtat 448261 cgttcttgaa tcgcctgaac ggcccgctca cagatcgcat cattataaca caagcaaatc 448321 gcatattttg gcatccgttg agcaatcgct tatgaacctt aggacggatt atatcgatat 448381 gcttttgatt cacagaccgg acccgctcat ggatccggag ggggtagcag aggcgtttca 448441 ggccttgaaa tgctctggca aggtcaggta ctttggcgtt tcaaatttta aagatcacca 448501 gtatcggatg ctggaatcat atttgcctga gaagctcgta accaaccaga ttgagctttc 448561 cgcatacgaa ttagaaaata tgctcgacgg cactttgaac ctgtgccagg aaaaacggat 448621 tccgccgatg gcttggtcgc ctctggcagg cggcaaagta ttcactgaaa acacggataa 448681 agaccgacgt gtccgtacgg cgcttgaatc cgtccaaggg gaaatcggcg ccgcttcatt 448741 ggacgaggtg atgtacgcat ggctgtatac gcatccggcc ggcatcatgc cgattgtcgg 448801 aagcggaaag cgcgagcgga tttccgccgc gataaatgcg ttgtcataca agcttgacca 448861 ggatcaatgg ttccgcattt ttacagccgt acagggttac gatattccat aaaaagcatc 448921 agtttaccag ctgatgcttt ttcaatattg tcacaccgct tagtgccaaa ttaccattta 448981 taagtgattg attctttctt gaaagcgttt tatattaaaa ggaaacctct ctatatcctc 449041 tactgcatct ccttgcgact tcatccgcac atcaagattg gctaggaggt cttttttatg 449101 tatatgactg ccagagaaca aaagctgtta aagcacttat tattacaaaa cagatatata 449161 accgtaactg agcttgctga gctgatgcaa gtcagcacga gaaccattca cagggaactc 449221 aaatcaatta aaccgctgat ggaaaccgtg gggcttacgt tagataaaca gcccggtaaa 449281 gggttgaaag cagtgggaag tcccgagggt aaacaaaagc tgcttactga tttatcatat 449341 gaacagcatg aatacagcgc cgacgaacgg aaactgctca ttctttgttc gttattagag 449401 tctcaggagc ccgtcaaact gtacacgctt gctcatgatc tccaggtgac gaatgccacg 449461 gtcagctatg acttagatga gctcgagaag tggatttctc cctttggact gacactgatc 449521 cgcaaaagag gttttggcat ccagctcata gggccggaga atgcgaaacg gaaaattgtc 449581 ggcaacttga ttgtgaaccg tctcgacatc caaatgtttt tggaagcggt tgaattaaac 449641 atcaaaggaa aaaccgattc ttcagagaaa atgttcgggg ttgtcagcaa aggtgagctg 449701 ttaaaaatgg agcgcatctt atttcagctc aaagaaaaaa tcgctttttc attgtccgac 449761 agctcctata tagcgctcgt cgtccatctg acgtatgcga tcgaacgaat taagcttggg 449821 gaaactatca ccatggagca aaatgagctt gaggaactga tgaatgcgaa ggaatacagc 449881 tccgctcttg aaatcgcggg cgagcttgaa cgtgccttcg gcgtgacgat tccagaggcg 449941 gaggtcggct atattacaat ccatcttcga agcgccaatc gaaaatacaa aacagaatac 450001 aaagcgcagg aaattgagct ggaaacagcc ctgcaaacaa agcggctcat tgcttttatt 450061 tcagacaaaa tcagaatgga tctgacgaaa aactactctt tatatgaagg cttgattgcc 450121 catttggagc cggccgtcag ccgcataaaa gaaaatattg agatatacaa tccgatgaag 450181 gaacagatca agcgcgatta ttttctgctt tatatggcga tcgaagaagg tgtcgaaaag 450241 tattttccgg gcatgtcctt ttctgatgat gaaatcgctt ttatcgttct tcactttggc 450301 tcggctcttg aaatcaaaaa agaagaagca aaagtgaaag cgcttgtcgt ctgctcaagc 450361 gggatcggct cctcgaaaat gcttgcctcc agactgaaaa aagagctgcc ggaaattgaa 450421 tcgtttgata tgtcatctct gatcgagcta aaggggaagg atgttcaagc ctatgatatg 450481 attgtgtcca ctgtaccgat tccttatgaa aacattgatt acatcatggt cagcccacta 450541 ttaaatgagg aagacgcaaa ccaggtcaag cagtatatca agcggaagat tccccttatt 450601 cttaacaaaa aaagaagctc gaaggaagag gcgcagcaag ctgatgtacc tgacatgctg 450661 gaggcggcgg aaagcatagg gcggtatatg gaagttatcc aagatgttct gcgccatttt 450721 acgctagctc aactcaaaac aaacccggac catagcatgc ttctgctaga gctttttcaa 450781 cagctgaaga aggatggcct gatccgtgat ccggaaaaag ccgcggtttg cctggctgag 450841 cgggagaaac aagggggatt gggaatcccc ggaacaaaca tggcgcttta tcatctcaaa 450901 aatgatgaaa tcgtcctgcc ttttttcaaa atgtttgatc tcagcacccc ctatgaagtg 450961 gatggcatgg acggaaatac cctcaggatg acacgcattc tcgtcatgat ggcgcctggc 451021 tcattatctg ctgaaggctc ggagatttta agcgcgatca gctcggcaat tatcgagagc 451081 ggagaaagca tggcggggtt tcaggaagaa ggaggacaag aattgtatca gcggttaaac 451141 cgcatatttt tcacatggat gaaagaaaaa aacatactgt aaacctgcat ggcacacgtc 451201 aaaaatttgg cgtgtgtttt tctgtggatg gggaacaaaa taagaaaatg tgggactatt 451261 ttatcattca gtattggaat aattccaaaa tgaaatagtt ttacaagtta tcttttttgg 451321 gttaaaatgg gtgaggtaag gaagaaaatc taacaaatta ttgaagattc aagagaatat 451381 aggagatgac gatatggaaa cattacagca tctgattctg catgacatgc cgaatagcga 451441 agaaatagag gctgtaaaaa gcggagacca tacactgaca tataaaggtt accgtaaacg 451501 gattaatcag ctggcgaatg ccatgcttca aaaaggaatt caaaagggcg accgtgttgc 451561 attgctttgc aaaaacggcc atcccgcctc aactgttatg ttcgccgcac ttgaaatagg 451621 tgctgttgtc gtacctgtca gctggcagct gaaaccatat gaaatgacag gcattttaaa 451681 agcaagtgaa ccaaaagcga tgttttacgg agcggagttt aaagagatac tggatgaagt 451741 tcttcctgaa ttgtcctcac tgtgtgtaac aatggaaaca ggaacagctt acgaaacatc 451801 tgctgaattt gaagcgctgt ttgcaggtcc tgatcatttg ccagagacgg aaatggtttc 451861 acctgatgat acagcacttc tgatgtttac atctggaaca acgggaaacc cgaaaagatg 451921 catgattaca catggcggca tatacagata cgttaaaaaa tccaacagct caatagcacg 451981 tatgaagggc cttcgttttc tcgcgtgcca tccgatttat catacgagtg cgctcatttg 452041 catcatgctt ggaacgtttg cagaaacaac atttgtgttt acaaaggatc aagatcctgt 452101 tcacatgctg aaggtcattg aagaagagaa gattcagacc gtgatggctc ttcctgtgtt 452161 ctacacgtat ttgcttgagg cgtgggaaaa gcaccaaact gacttatctt cgcttgttat 452221 tttaatgaca ggcggaacaa aagtgccgag cagcctaata agccgctatc ttgatattgg 452281 cattccgctt gcgcatggct atggaagtac tgaggcttgg ggcatcagca catggacgcc 452341 tgatatggga atggataaag cggcatctgc aggaaaacct gtggcaggtg ttaaagtcaa 452401 agtggaagat cctctgaccg gagaagaact tcctcaagga gaaatcggcg aaatcgttgt 452461 tcatactcca ttcttattta aaggctatga agacaatcct gaagcaacag cgaaagtgct 452521 gcaaaatgga tggtttagaa ccggagattc aggatatgta gatgaagatg gctttatttt 452581 catcacggga cgctacaagg atgtcattat ttacggaggc gataacgtct atcctgatca 452641 ggttgaagaa gttatccagc agatcccggg aatccttgaa acggctgtgg tcggtattcc 452701 tgacccgctt tacggtgaaa aaccgaaagc ttttatcgtg aaaaatggcg gccagcgcat 452761 cacggaagag gatgtcatcg cattttgtaa agaacgcctg tccgcttaca aaatacctga 452821 agttgaattt gttaacgaac tgccgaaaaa caaccttggc aaggtgaaaa aagacgtcct 452881 gcgcaatcag gctgtacatt cataaaagaa gaagcccgtc cactttatgt ggcgggcttc 452941 tttgcagttg cacagacgga aagctcaggc ttaatgttct taaattgtat atcaatgtct 453001 tcgaagccgg ctgctttaaa gtcagcaatc atctgtcttc caaatgattt ggttttctca 453061 ggactggcat ccgcttcccg cggctgcatc gtaatggctg ctttgccgcc tggctttaat 453121 gcccgataaa tctgttttat gccttttgtt tggtcattcc aaatggtgta gttgttaacg 453181 gaaatcactt tatcataaaa cgaggcgggg agaggaaatg tctcgatgct tccttgtatc 453241 aggcgtacgc cctttggttt cactctgcgg gcggccagct tcagcatggc ctctgataca 453301 tcaatcccat gaagatgaac atccttctcg cgtttcagca tctgctgcat gcagtatccc 453361 gggccaaacc cgacttctaa aatgctgtcc ccgcgcgtga tacccagctg attgattgtc 453421 cactgattca gtgtttgatt ttcagcagcc atgatgtacc cggcaatcat gccgatgacg 453481 ccctttggcc tgctgaatct tctagaaagc atgttaatca ttcagcaacc aacccccttt 453541 ttgagttaat ttcctctcag cgttccatgt gaaacatttt tctgataaag caatgcgaag 453601 gtgccaagcc atgtttatcc aaagagtgtg tgaggtacac aacaaataga catgaaaaca 453661 aaggaggaga atcatcatgg caaattatcc aaaagaactg ccggcacaaa ctcaaagtcg 453721 ccagccggga attgaaagcg aaatgaatcc aagtccggtg tatgagtacg aggattataa 453781 aggagcagac aaattaaaag gaaaagtagc tcttattaca ggcggcgaca gcgggatcgg 453841 acgcgcggtt tccgtcgctt acgcaaagga aggcgcagac atcgccattg tgtataagga 453901 tgagcatgaa gacgctgagg agacgaagaa acgtgttgaa caagaaggcg taaaatgcct 453961 gctgattgct ggtgacgtag gtgaagagga attctgcaat gaagcggttg aaaaaacggt 454021 caaggaacta ggcggccttg acatccttgt caacaatgca ggtgaacagc acccgaagga 454081 aagcatcaaa gatattacga gcgaacagct tcaccgcaca ttcaaaacaa atttttattc 454141 tcaattttat ttgactaaaa aagcaattga ttacctgaaa ccgggcagcg ccatcatcaa 454201 tacgacatcc atcaacccgt acgtagggaa cccgacactg attgattata cagcgacaaa 454261 aggggcgatc aatgccttta caagaacaat ggcgcaggcg cttgtcaaag acggcatccg 454321 tgtaaatgca gtcgcgccgg gtccaatttg gacgccacta atcccagcta cgttccctga 454381 agaaacagtt gctcaatttg ggcaagatac gccgatgggc cgtcctggac agcctgttga 454441 gcacgtcggc tgttatgtgc ttctggcatc agatgagtcc tcttacatga caggtcagac 454501 cctgcatgtc aacggcggaa actttgtgac gacataagag ggagtgagac atatgggcat 454561 cacgaaagaa gaagtgaaca gctactatca aaaagcaggg attgtattaa cggacgagga 454621 agtagaccaa atccagctga tggattacgg cttaggaaaa gaaagaaaag tcgggctcca 454681 gctcttcgtc tacgtcaata cagaccgtta ttgttcaaag gaattggtgc tgtttccggg 454741 acagacttgc ccggaacacc gccatccacc ggtcgacggc caggaaggca agcaggagac 454801 cttccgctgc cgctacggaa aagtgtatct ttacgtagaa ggagaaaaaa cgccgcttcc 454861 aaaagttctc cctcctcagg aagacagaga acactatacg gtctggcacg aaattgagct 454921 agaaccgggc gggcaataca cgattccacc aaacacaaag cattggttcc aggccgggga 454981 agaaggtgcc gtcgtgacgg aaatgtcatc gacgagcacg gataaacatg atatctttac 455041 cgatccaaga atataaggat gggcttaaca gcccatcctt tttgtattga aaaaaacaga 455101 atcatcgcta taatgggtaa aaaaggaaag agggcgaggc aatgttcact tgcaaggtaa 455161 atgagcacat caccatccga ttattggagc cgaaggatgc ggagcggctg gccgaactca 455221 ttatccaaaa tcagcagcgg cttggcaagt ggctgttttt tgcggaaaat ccaagcagcg 455281 ctgacacgta ccgagaaaca atcattccag attggcggcg ccagtatgcc gacctgaacg 455341 gcattgaggc gggtctcctt tatgacggca gcctatgcgg catgatcagc ctgcataacc 455401 ttgatcaagt gaatcgtaag gcggaaatcg gatattggat tgccaaagaa tttgaaggga 455461 aaggcattat tacagctgcc tgccgaaaac tcattacgta tgcttttgaa gagcttgagc 455521 tgaatcgtgt ggcgatctgt gcggctgtcg gaaacgaaaa aagcagagcg gttccggagc 455581 ggatcgggtt tctagaggaa ggaaaggcac gggatggctt atacgtaaac ggcatgcatc 455641 acgacctcgt ctactacagt ctgttaaagc gtgaatggga aggcgaaaaa taaagagcac 455701 actttcttgt ttaaatcttc cccggatgtg gaaaagtaac agcggagacg ttaaaaagga 455761 gtgattcgag atgaatcagc aagacattaa acaaaaagtg cttgatgttc tagatcacca 455821 taaagtaggt tcgctcgcaa cagttcaaaa gggcaaaccg cattcccgct acatgacttt 455881 tttccatgac gggctgacga tttacacacc gacaagcaag gaaactcata aagcggaaga 455941 aattgagaac aaccccaatg tccacatttt attaggctat gattgtgaag gttttggcga 456001 cgcatatgtc gaagttgccg gaaaagcaaa gatcaacaat tcggcagaac tcaaggacaa 456061 aatatggagt tccaaattag agcgctggtt tgacggcaag gatgatccga atctggtgat 456121 tcttgaaatt gaaccggagg atatcagatt aatgaatgcc ggggagaaaa caccggtctc 456181 actcgaacta taaaaaattt gtgttttcag gggcgatatg ttattatgaa tagctagtaa 456241 gaaaaataag caaataaaaa agaaagtaaa cttctttttt ctgttttgag agagaagctt 456301 accgcttccc aagcagcata accagctgcc cttattcttt tccttcataa caaatcgccc 456361 ctaacgatga gatggaaaaa agactttttt gttttacaat tcacaccggc gcggcttcgg 456421 agccgcagtg acgattgaga ggtagggctt tcgttgtctt gtgttcaaga aatttccatg 456481 gtgtttactt tccagaatga ttcttcggaa caatgcttta tgaatctaac ccgcctgact 456541 tggcggatga tataatcttt atttgcgtat agaaaagaat aagacaaacc gcccggcgta 456601 cgccggacgg tttttttatt gcaaaaaaca catcgtactg aaacctcctt gtcttctttc 456661 cagtcttatc tctaggatga aattggagga agaataacgt gcatgtcatt acaacacaag 456721 tactttttat tttttgtttt ttattgctga ttcactcgat agaaacctta gcctatgcga 456781 caaggctttc cggagctcgc gttggattta ttgcgtccgc gctttctctg tttaatgtca 456841 tggtcatcgt atccagaatg tcgaatatgg tgcagcagcc ctttactggg catttaattg 456901 atgatgctgg aaaaaacgca ctggcgattg taggggagca gttccgcttt ttaattttcg 456961 gatcgacagt cggcaccatt ttgggcatta tcctgctccc gtcttttgtc gctctttttt 457021 cacgggcgat tattcacttg gcgggcggcg gcggctccgt ttttcaagta ttccgaaagg 457081 gattctcgaa acaaggattc aaaaatgccc tttcctattt gcgtctgccg tccatttcat 457141 atgtaaaagg atttcatatg cgcttgattc cgaagcgttt gtttgtcatc aacatgctga 457201 tcacatcgat ttatacgatt ggtgtgcttt cggctttata cgcaggcctt ttggcgccgg 457261 agcgcagcac gacagccgtc atggcttcgg gtttgatcaa cggaattgca acgatgctgc 457321 tggctatttt tgttgatcct aaggtatccg ttcttgctga tgatgtggca aaaggaaaac 457381 gaagctatat ctatttaaaa tggacctctg tcacaatggt cacatcaagg gtggcgggca 457441 cactcctcgc ccagctcatg tttattcccg gggcctacta tatcgcgtgg ctgacaaagt 457501 ggttttaata agaaaggctg gatcataaag atccagcctt tttgcgcttc cttatttata 457561 gttccttaat ccgcggtcgt acaaaaaatt tccgaatggg acgaaagcgg cgatgaagcc 457621 ggcagctgac catttcagcg gccatttgac agagaaggtt gcataagcca agacaagcaa 457681 atacaaaatg aacaacccgc cgtgaaccga accgacaatt gtcaccgcaa gcggaaggcc 457741 tgcccaatat ttaagcggca tagcgatgaa caacaggatt aagagtgaca ttccttcaat 457801 aaaacccatc gtgcgaagtc ttccgatcgg cgtgtgcagc ataaatcgcc ctccttgtgg 457861 acacgttttc attttatact ataaacaatc cgggggggca tatgacagct ttcaaaaaat 457921 gttcggaaaa cattcatttt tacatgcctt ttctagggaa ctgtacttgt catttacaaa 457981 aatacccgag ataatgtgta caaaatcaaa aaagaaggat gttgaaatga aacttgacca 458041 gattgatctg aatatcattg aggagctgaa gaaggacagc cgtttgtcga tgagggaatt 458101 aggcagaaaa attaagctgt cgcctccatc tgtaacagaa cgggtaagac agcttgaatc 458161 gtttggcatc atcaagcaat acacgctgga ggtcgaccag aaaaaactgg ggcttcccgt 458221 ttcctgcatt gtggaagcaa ccgttaaaaa cgcggattat gagcggttca aaagctatat 458281 tcaaacattg ccgaatattg aattttgcta ccggattgcg ggtgcagcct gctatatgct 458341 gaaaatcaat gccgaaagcc tcgaagcggt agaagatttc attaacaaaa catcgcccta 458401 cgcgcaaacc gtcactcacg tcattttctc agaaattgac acgaaaaacg ggcgcggtta 458461 gagagtgccg cgcgaagtct gttataataa caggatgagc gtgaaagaaa gagaagtgat 458521 caagcatgtc aaaaacagtt gtattagctg aaaaaccttc agtcggccgg gatttagccc 458581 gggtactgaa gtgccataaa aaaggaaacg gttatctcga aggcgatcaa tatattgtga 458641 cttgggcttt aggccatttg gtgacgcttg ctgatccgga aggctacgga aaagaatttc 458701 aatcatggcg cctagaggat ctgccgatta tcccagaacc cttgaagctt gtggtgataa 458761 aaaaaaccgg aaagcagttc aatgcagtca aatcccagct tacccgtaaa gacgtcaatc 458821 agattgtcat cgcgactgac gcaggccggg aaggtgagct tgttgcgcgc tggatcattg 458881 agaaagcgaa tgtccgaaaa ccaatcaagc ggctgtggat ttcatctgtg acggataaag 458941 cgatcaagga aggttttcaa aagctgcgca gcggcaaaga atatgaaaac ctgtaccatt 459001 ctgccgtcgc cagagcggaa gcggattgga ttgtggggat caacgccacc cgtgcactta 459061 ccacaaaatt caatgcccag ctctcatgcg ggcgtgtgca gactccgacg cttgccatga 459121 ttgcaaagcg cgaggcagac attcaggcgt ttacgcccgt tccgtattac ggcatacgtg 459181 ctgcagtcga cggcatgacg ctgacgtggc aggataagaa atcaaagcag acgagaacgt 459241 tcaatcaaga tgtaacaagc cgtttgctaa aaaatctcca aggaaagcaa gcggtcgtag 459301 ctgagctgaa aaaaacagcg aaaaaaagct ttgcgcctgc gctttatgat ttaacggagc 459361 tccagcgtga cgcccacaag cgcttcggtt tttctgccaa agaaacgctt tctgtcctgc 459421 agaagctata tgagcagcat aagctcgtca catatccgcg gacggactct agatttttat 459481 ccagtgacat cgtcccgacg ttaaaagacc gtctggaagg catggaagta aaaccgtatg 459541 cccaatatgt cagccaaatt aaaaaacgcg gcattaaatc tcataaagga tatgtcaatg 459601 acgcgaaggt gtcagaccac cacgcgatta tcccgaccga agagccgctc gttctcagca 459661 gtctgagtga taaagaacga aagctgtatg acctgattgc gaaacgtttc ctggctgtat 459721 taatgcctgc attcgaatat gaggaaacaa aggtcatcgc agaaatcggc ggagaaacct 459781 ttacggcgaa aggcaaaacc gtgcagtcgc aagggtggaa agccgtttat gatatggcgg 459841 aagaggatga tgagcaggag gatgacagag atcagacact tcctgcgctt caaaaaggcg 459901 acacacttgc cgtccgcacg ttaacggaaa caagcggcca aacgaagccg cctgcccgct 459961 ttaatgaagg gaccttgctg tcagcgatgg aaaacccaag cgcgtttatg cagggagaag 460021 aaaaaggcct cgtcaaaacg cttggagaaa caggcggcct cggcacggtg gcaacgcgtg 460081 ccgacattat tgaaaaactg ttcaacagct ttttaatcga gaaaaaaggc caagatattt 460141 ttatcacatc taaaggaaaa cagctcctgc agcttgttcc ggaggatctg aaatcaccgg 460201 ccttaacagc agaatgggag caaaagctgt ctgcgatcgc ggccggcaaa ttgaaatcgg 460261 ctgtttttat taaagatatg aaggcttacg ctcaccaaac ggtaaaagaa atcaaaaaca 460321 gcagccaaac cttccgacat gacaacatta cgggaacggc atgtccggaa tgcggcaaaa 460381 tgatgctgaa agtaaacggc aaacgcggga cgatgctcgt gtgccaagat cgtgaatgcg 460441 gaagcagaaa aacgattgcc cgaaaaacaa acgcacgctg cccaaattgc cataaaagaa 460501 tggagcttcg cggccaaggc gagggccaaa cctttgcgtg tgtgtgcggt caccgtgaaa 460561 agctctctgt atttgaaaaa cgaaaaaaca aagacaaagc gcgtgctacc aaacgggacg 460621 tatcctctta tatgaaaaaa caaaataaag atgagccgat taacaacgcg ctggcagaac 460681 agctgaaaaa actcggtttg gataaataat aaaaaaacct gtgcctatcg cacaggtttt 460741 ttattggact taggtcctgt tttcttaatg ttcaaaaagg gaaaaaaaag ctagcaatct 460801 gcattttttt tcttttatag taaatgtact ttgtaacatg gcagtcatat tttcgtctat 460861 aactatttgt gagcgtctga tttgcttcag gcgacaaagg gggatttgcc tgtgaggcat 460921 gtactaattg ctgtcatctt attcttctta tctatcggac tttccgcagg gtgtgctgaa 460981 gctggaaaca agacccaaaa tcagtcggcg acagaagtga atgccagccc gctccagccg 461041 gcggaatatt tcatctatca caatttaatg aatgacaaag ggctgatcaa aaccgatttt 461101 tcagaccagc cttcttactt gtcggaatct ctcggactgt ggatggagtt tctgctcagc 461161 aaaaatgacg caccacattt ccaggatcaa tatcagcatc tgactgattc atttctgatg 461221 agcaatcact tggtgacgtg gaagattcaa aatggccaag cgagcgggac gaatgcgctg 461281 atagatgata tgagaattat gctgtctctt gaccaagccg ccgcaaaatg gggccgcagc 461341 gactacgcgc aaacggctag ggatatcggc acgtctttga agacatacaa tatgaacaac 461401 gggtttttta cagactttta cgactcacag gccgcttcaa aggatgtgac gctttcatac 461461 gtcatgcctg atgccttagc tgtcttaaag aagaatggaa tcatagacga agaaacagaa 461521 cagcggaatg ccaatgttct ctattcagct cctttaaaaa atggctttct gccgaagaca 461581 tacagctcgg agacgaagga atacacatat gatagtgaaa tcaacctgat tgatcagctt 461641 tacgctgctt ggcatttgcc ggaaggggat gaaaaagcat ctgttttagc ggactggatc 461701 aagcaggaat ttcagaaaaa cggaaagctg tacgggcggt attcggcata tacgaaggag 461761 cctgccgtcc aatatgagtc tccatccgta tatgccttag ccgtattgtt tttgacaaaa 461821 cagcatgaaa acagttctgt catcaaagcc atatatgata gaatgaatga ctttgaaatt 461881 catgatccgg tgaaatcgta ttatggaggc tatatgagcg gcactcagac gcattcattt 461941 gacaatctgc tgccgctgtt agccgaaagg aagcttttta atgaaaatat cattcagtga 462001 atcacaaaaa ttatttgctt atttttcagg gctcatcgcg gccctgtctt tgtttattta 462061 ttatgtgtca gcccagcaat cagaaggtgc tctgatcctt tgcatcacat ttggcgtcat 462121 cgccgcaggc atctggttcg gcccgattta cgcgctggca gtgaccttaa tcgtactctt 462181 tgttctcggc accttaatga tgtttttcca gactggacag acatcgctct ttccggctga 462241 ggaagggctg cgaatgcttg tcgtgtgggg aatcgcgctt ttgctgtttt cttttatttc 462301 tggaagaatc cacgatatta cagcagagct tcggcgctca atgacacggc ttcaatccga 462361 aattaaaagc tatgttgctg ttgacagagt gactggtttt gataacaagc aaaggatgaa 462421 gctggaactt tcagaagaaa tcaagcgggc ggagcgctac ggcaattctt ttgtgttttt 462481 gctgctccat atgcattatt tcaaagagtt taagtctttg tacggtgaaa aagaaacgga 462541 ccgcctcttc caatatgtcg gtcagcaaat caggacaagc gttcgggaaa cggataagaa 462601 attccgtccc tctgacgagc gtatcgggat cgtgctgacg cacacgcctg ctgaacatat 462661 gccggccgtt ctgactaagc tgaagaaaca attggataca tatcagctgg aaaatggaaa 462721 gtatgtgtcg cttacgttcc acgtttgcta tttgccctac cgcaacgata tccaaacagc 462781 tgatcaattt ttagaagaac tggaaaacga gatgatgatg aatgaactat aaaggaatca 462841 cattgctatg cgtcatgatg cttctatttt cagctattgc gtcttttccc gtttctgcgc 462901 aagcgaaaga tcaggatgcc ggcattctca tcatctactc aaccttggac ggcaaagagt 462961 cgtcacaagt caaaatgctc gatttgcttg cgggccactt tacatcccat gtgacagtca 463021 aaaaagattc agacgttgaa gcgtcggatt tcaaagggaa agaccatgtg atttattacg 463081 gccaaacgaa aagaaagctc agccaaaaat tgctgtctct tatcagcggc gtgaaaaaac 463141 cggttgtcgc cattggctat aacgcaggcc aaatcagcca attttctggg ctttcattag 463201 cccgcaaaga aaatgtgttt caggttcaca gcaggtcaga aaaggccgat gtgtctctgg 463261 aaagcgggct taacgtgctg agtgtatcag gcctgaaagg aacggcgctt tacaccttca 463321 aagcggatga aggcacaacg cattctttta tatggaaaac aaaaaaaggg aatgtgtaca 463381 ttggattaac aaatttgtta aatgacaatt tgatcgtggc gaaacagctc agagaagctt 463441 tcggagagaa ggcggggacg acgttattgt atttgcgtct cgaggatatc agcccgatgt 463501 ctgatgaaaa actgctgctt caagccggta catacctgca taagcggcat attcctttta 463561 tcctggcggt cattccggtt tacttgaatc cggaaacagg cgacaaagtg tatttgtcta 463621 atcaaccgaa gatggtcaag gtgctgaaga agctgcaaag catgggcggc agtatcatag 463681 ttcacggcta tactcacgct tatcgctaca gtgaaacagg agagggattt gaattttggg 463741 atgcaaaggc ggatcagccg attacatccg gaaatgccga agaccccccg tccattttgg 463801 agaaagaaca ggacttcccg aacgaacaag cctatcacag ctatcttgaa ccatttcggg 463861 aaaaggaaga aacgtataca aaacaaaaac tgacgcgtgc cattgaggat ttgacatcat 463921 cgggtcttta cccgctggcg tttgaagcgc cgcattacac gatgtccgaa tatggctatc 463981 aaatcgcctc gcagtatttt acaagcattt tcggccaggt ccagctcagc agcacaacat 464041 ggaaaacatc cggtgcacct ccgtttgtga ctgctccttc gatgctgcac ggaatgacgc 464101 tttatccgga aacgatcggc tttgtcgaca catcgaagca aaacccgctc ggtgagatgg 464161 aggagcatat ctcccagatg attgattttg aaggcggagt agccggagga ttttatcacc 464221 cgtaccttgg gatgaaatat ctgcctgagc tggttgatca gatggaacgc attccagaca 464281 gtgaatggct tgatttaaag aaaacgaaac aaaccgtcaa aacagacaaa gtggaaattc 464341 atacaagcgg tgacggaacg attcaggtga aaaacggcgt aagccccatt tacgagtttt 464401 tcgatcatca ccggcaaacc cctctggaaa aggcgttatg gattctctcc gctgttgtgc 464461 tcttatttgt catcatgttt gtcagttata cgttttactt gagagccaca ttgaaaaaac 464521 gaatttttaa ggagagaaga agccttgggt aatacgctgt tctttatctc gctaagttta 464581 atatgggtta tgcttctcta ccacatgttc ctcatgcagg gcgggtttcg ccactatatg 464641 accttcgaac ggaatatccc gaagtggaga gaaaatatga aggaactgcc gaaggtcagc 464701 gtcctcatcc cggcgcataa cgaagaggtt gtgattcggc agacgctgaa ggccatggtc 464761 aacctttatt atccgaagga ccggctggag attatcgtcg ttaatgataa ttcatcagac 464821 cggacgggtg atatcgtcaa tgaattttcc gagaaatacg atttcatcaa aatggtgatt 464881 acgaagccgc caaatgcagg aaaaggaaaa tcctctgcac ttaactcggg ttttgccgaa 464941 tcgaacggcg atgtgatctg tgtgtatgac gccgacaaca cgcctgagaa aatggccgtg 465001 tattacctcg tgctcggcct gatgaatgac gaaaaggcag gcgccgtggt agggaaattc 465061 cgcgtcatca atgcggcaaa gacgctgctg acgaggttta ttaatatcga aacgatctgt 465121 tttcagtgga tggcccaggg aggcagatgg aagtggttca aaatcgccac gatcccaggc 465181 accaacttcg cgatccgcag aagcattatc gaaaagctcg gaggctggga tgacaaagcg 465241 ctcgctgagg atactgagct gaccatccgg gtatataatc tcggctatca catccgcttt 465301 ttccctgccg ccatcacgtg ggagcaggaa ccggaaacat ggaaggtatg gtggcgccag 465361 cgcacccgat gggcgcgcgg caatcaatat gtcgtgctca aatttttggc gcagtttttt 465421 aagctgaaac gaaaacggat tatctttgat ttgttttatt ttttctttac gtacttcctg 465481 tttttctttg gcgtgatcat gtcaaatgcg atttttgtag tgaatttgtt ttatgatttg 465541 catttgtctg ttggattttt ggcaatgatt ctctggattt tggcgttttt cttatttatg 465601 acagaggtca tgattacgtt gagcattgaa aaaacagaaa tgaacaagca aaactttttt 465661 atcgtatttc tcatgtactt cacatactcg caggcatgga ttgtgcttgt tatctactct 465721 ttattcgtag aaatcaagca ccgtttattc aagcaagagg tcaaatggta caagacagaa 465781 cgatacaatc aacataaaag cgggtgacct ttttgaaaca aataatgatt tttctcacaa 465841 gcttcatgct gctggcgatg actggacaaa cggctcttgc caaagacgta caggtcagcg 465901 gttcgctcct tgggaaaagc agccaagaac aagccaaaca gcaggtgctg acaagcgagc 465961 tgattacact gtatggatca aaagacagcg cagagctgac gtatcagatc ccggcaggcg 466021 cctcttcggg caatcagcaa ttggtaatcg aatacgaggc atcaaatctt ttaatttctc 466081 catcatcgtt aacggttgtc attgatgatg aaccggtcaa gacgttaaag cttgatggtg 466141 attccaaacg gaaaacagtg aagctgaatc tgaataaaag ccagtctgcg caaggctatc 466201 acaacgtatc gctgaaattc tacggcgtaa tgaaagaggg cgtgtgcgtc agacaggata 466261 catcaggcaa ctggatcaaa atttatccgg acagccggct gacacttgct gacagcagtg 466321 aagcgaaggg aacgtcgctg gaccattatc cgtatccttt cgcccaatct ggaaatacag 466381 cggaagaaac agctatcgtc attccggata acccaagttc agcagaaata gaagctgctg 466441 ttaaaacaga aggctatttg aaaacggtgg acagcagtgt cagtattgcg tatgtcacgg 466501 aatctgaact gaaaaaaatc gataagccga cgattgttat cggcgtggac aagcattgga 466561 acggcaaagt gaaaaaactg ttgaaacaag ccgggctaca ggcaaaagga gaaaaccttc 466621 tgcttgcgga gcgggtgctg aaagcagagg gcaaacagca gccggttctg tttgcgcaag 466681 cggcgtccga ggacgcgctc acaaaaaaaa tcagcgtgat gacagatcag acatatacag 466741 gccagctcag cggcgataca ctttcaatca gcaagcttca gcagactgaa aaaaaagaaa 466801 gcgataagct gacccttgag aattttggag cgggtgatat cacaattgga gccgacaaaa 466861 catcttcagc acattatttt tatccggctt cggctgtttt agatgaaaac caatcggcga 466921 agctgtcgct taaactgaaa aagtctgaaa cgattcaagc ctcaacggct gaaaacgagt 466981 cagcctctca ggctgcagaa ctgaaagtga tgatcaacgg ccagccgcac tcggtccggc 467041 ttgatgaatt aggaaaagaa gataaaaacg gattctatca tgtcacagtg aaagtggacc 467101 ctaagctgct gcaaaaaaac cgctacattg atattcagtt cgtcacgacc ggtttaaagg 467161 aaaacaaccc ttgtaacacc actgatgaag aaaagtgggt ttttatcgat aaaaacagta 467221 cattatcata cgccatcaaa ggcatgtccc cgtcagcgga ttttcaagag tggccgctgc 467281 cttacgccgg aaaccaggat caaacaacgt taatcgtgct tcctgacacc gtaagccaat 467341 cgaagctaga ggagctttct ctcgtaacag aatcctttgg caacgaagca cagcattcat 467401 atacggtaaa gaaatcatct gacgttacag caaatgatgc gaaaggacga aacctcattt 467461 tcataggagg gatcaatcaa ttttctcttc tgaaggagaa atcatcagat ctgcttgtgc 467521 cgcaggaaaa gaacggctcg tttgatgtat ctagtttcga gatgctgaat gagacgacaa 467581 aacaagtggt atttacccaa gcatcggttt gggattcacg ctatacaatg gctgtctttg 467641 caccgtcaaa aggagatggc acggctgtca caaaagagat catcagttat ctgaacagca 467701 acgatgagtc ggcaaccgtc cttaatgaaa caaacagcca gcaggtgttt acaaaccacc 467761 agcagctcaa atcggaaaca aacagttccg atgcagaaca accaacacag gatcatagcc 467821 agaaatggat gtatattggt gtgctggcac tcattatggt ggttgcggca gtgttcattt 467881 ggattgccgt aagacgcaaa aaaagaaaga cagatacaga ataaaacaga ggcgatttta 467941 gcctctgttt ttttattttt ggtaagtaaa ttccatttgt ggaacctgtc attttatttt 468001 tttctctcag ccaataagcc tctttacaac gtgcgggaac gggagtatga tctcttttag 468061 aaaacaaatc gcttaatctg aaatcagagc gggggaccca atagaacggc tttttgccgt 468121 tggggtgaat cctttttagg tagggctaac tctcatatgc ccgaatccgt cagctaacct 468181 cgtaagcgtt cgtgagagga gatgaatgaa acctgtgttc gatgttatgg cacaggggca 468241 tccgtttgcc tctgtgtttt ttgttgttca tttttgaatg caaatcgcat acagagacat 468301 catagcagaa aggactatca tcaacatgtg agagcaagac actgatggat gttttattgt 468361 tttaattgaa aaatgagaaa ttaaaagggg aagacatcga tgtatcattc aatcaaacgt 468421 tttttgattg ggaaaccact aaaatcccaa gcagctggag agcaaaaact gacgaaatta 468481 aaagccttgg ctatgctttc ctcagatgcg ctgtcatctg tcgcatatgg gacagaacaa 468541 attctaatca ttttggcaac aatcagtgca gccgcatttt ggtactccat tccgattgcg 468601 gttggcgttc tcatcttgct gctcgcactg attctttcat acaggcaaat tatttacgct 468661 tatccgcagg gcggcggggc gtatatcgtt tctaaagaaa atctcggtga aaaaccggga 468721 ttgattgcgg gcggttcatt gcttgttgat tatattttaa cagtagcggt aagtatttcc 468781 gcaggcacgg atgccatcac gtcagccttt cctgcattgc atgattatca tgtgccgatc 468841 gctatttttc tcgtgttagt gattatgatt ttgaacctgc gcgggctttc ggaatcagca 468901 tccatacttg cctacccggt ttatctgttt gtggtggcgc ttttggttct cattgcagtc 468961 gggttgttta aacttatgac aggacaaata gaccagccag cccatcatac atcgctcggc 469021 acacctgtag ccggcattac gctatttttg ctgcttaagg ctttttcctc cggatgctca 469081 gcgttgaccg gggttgaggc catttctaat gcgattcctg cattcaaaaa cccgcctgcg 469141 cgaaacgcgg caagaacgct tgcgatgatg gggattttgc tggcgattct gttttccggc 469201 atcacggttc tcgcgtacgg gtatggtacg gcgccgaaac ctgatgaaac agtggtttca 469261 caaattgcgt ccgaaacctt tgggcggaat gtgttctact atgtcatcca aggtgtcaca 469321 tcgcttattt tggttcttgc ggcaaatacg ggattctcag ccttcccgca gcttgccttc 469381 aacctggcga gagaccagta tatgccgcga atgtttacag tcaggggcga ccgcttaggc 469441 ttctcaaatg ggattatctt tttaggcttt gcctccattg ttctcattat cttattcggg 469501 ggacagacgg agcacttaat cccgttatat gctgtgggcg tatttattcc atttacgctt 469561 tcacaaaccg gcatgtgcat gaaatggatc aagcaaaaac caaaaggctg gatcggaaaa 469621 atgctgatca actcctgcgg cgctctgata tcatttatgg ttctatccat tctgtttgtg 469681 acgaagttta atgtcgtatg gcctgtgtta atctttatgc ctatcgtcgt tttgctgttt 469741 tttgcgatta aaaatcacta tactgcggtt ggtgaacagc ttcgcatcgt agacaaagag 469801 ccggaagaaa tcaaaggcac cgttgtgatt gtgcctgtgg ccggtgtcac caccgtcgtg 469861 caaaaatcga ttcactatgc gaaatcactg tccgatcagg tgatcgccgt tcacgtgtca 469921 tttgacagag aacaggaaaa gaaattcgaa aaacgttggg aagagcttaa taacggagtg 469981 cgtctcgtga cgcttcactc ctcttacaga agccttgtcc atccgtttga taagtttttg 470041 gaaacagttg aggcaaaagc gaagaaggag cagttttccg ttatggtgct gtttccgcaa 470101 tttataacga aaaaacgctg gcacaccatc cttcacaacc aatcggcctt cctcctcaga 470161 gtccggctgt tctggaaaaa ggacataatg gttgccacac tgccgtatca ttttaaaaag 470221 taaagctcta ggaccaaggg aatcaccttg gtccttttta gcgggaaaag gaggtatggg 470281 ggtgtataca caaggtgctt ttgtgatcgt attgaacgaa agtcagcaaa ttctgctggt 470341 gaaacgaaaa gatgtccctc tatgggattt gccgggcggc agggttgatc ccggggaatc 470401 ggctgaggaa gcggcagtgc gggagatatt ggaagaaacg ggatacaatg cagcgctttc 470461 tgcgaaaata ggtgtttacc aaaggccaaa gtttcaagat gaacagcatc tgtttttcgg 470521 aagcattaca ggcggacaag caatggctga cggcacagag acagcgggat taaagtgggt 470581 ttccccgggg cgtttgccgc tttttatggt gccgaatcga aaaaggcaga tcaatgattt 470641 caagaacggc gctcaagatg taaatgtcac cgtcaaggat agcgggttgc tcgcggcgat 470701 cgacctgttg aaaagaagac tgggcaagtg attcaggtct ccgggtttta aagcctttct 470761 cctgtggtat tgaaaaaagg aaaaaggagg atacgttatg gcacacaaaa ctgcaggaca 470821 agcaatgaca gagctgcttg agcaatgggg agttgatcat gtatacggca tccccggaga 470881 cagtataaat gagtttatcg aagaattaag acacgaaaga aatcaactga agttcattca 470941 aacccgccac gaagaggtag cggcactggc agccgcggct gaagcaaaac tcaccggcaa 471001 gatcggagtc tgtctgtcaa tcgcagggcc gggagcggtg cacttattaa atggtttata 471061 tgatgctaaa gccgacggcg cccctgtgct ggcgattgca ggacaggttt cttctggcga 471121 agtcggacgg gactatttcc aggagattaa gctggagcaa atgtttgagg acgtggccgt 471181 gttcaacaga gaggtacata gcgcggaatc acttccggat ctcttaaatc aggcgatcag 471241 gaccgcctac agcaaaaaag gcgttgcggt attgagcgtg tcagatgatt tgtttgcgga 471301 gaaaatcaaa cgggagcccg tgtatacttc accggtgtat attgaaggga acctagaacc 471361 gaaaaaagaa cagctcgtca cctgcgccca atatattaat aacgctaaga aaccgattat 471421 cctggcaggg cagggaatga aaaaggcgaa acgggagctc ttagaatttg cggacaaagc 471481 cgccgctccg atcgttgtta cactcccggc aaagggtgtt gttcccgata agcacccaca 471541 ttttctcggc aacctcggtc agatcggaac aaagccggct tacgaggcaa tggaggaatg 471601 tgatttatta atcatgctcg gaacgtcatt cccgtaccgt gattatttgc ctgatgacac 471661 gccggcgata cagctcgatt cagacccggc aaaaatcgga aaacggtatc cggtgacagc 471721 gggccttgtc tgtgattcgg ctctcggttt gcgcgaattg acagagtata ttgaacgcaa 471781 ggaagacaga agattcctga atgcctgcac agaacatatg cagcattggt ggaacgaaat 471841 tgaaaaagat gagacagagg caacaacacc gcttaaacct cagcaggtcg tggcccgtct 471901 tcaggaagcg gcagccgatg atgcggtgct ctctgtagat gtcggcactg tgacagtctg 471961 gatggcgcgt catttcaaaa tgaacgcgaa tcaggatttc atcgtttcca gctggcttgc 472021 gacaatgggc tgcggcctgc cgggagcgat tgcagcgagc ttgtccgaac cggaacgcca 472081 ggcgatcgcc gtctgcggtg acgggggatt ttccatggtc atgcaggacc ttccgaccgc 472141 cgttaaatat aagctcccga tcacagtcgt tattttaaac aacgaaaatc tcggcatgat 472201 tgagtacgag cagcaggtca aaggcaatat cgactatgtc acaaaacttc aaaatgtcga 472261 ctatgccgca tttgcagaaa gctgcggagc aaagggcatc aaagtgacca aagcggaaga 472321 gcttgcgccg gcttttcatg aggcgctgca ctctgaccaa ccggtcgtag tggatgtcat 472381 gattggaaac gaaccgccgc ttcctggcaa aatcacctac gggcaggcga aaggctttag 472441 caagtacatg ctgaaaaact tcttcgaaaa ccaaaaattt gaaatgccgt cactgaagaa 472501 aagtttgaaa cggttatttt aaaaaaacag gggccctaag agcccttgtt tttttttttt 472561 tttttggaaa caaatgtatt ttcagcatgt ttgaattcat aaaatgatcg gtatatgtat 472621 taggaactga tttcgccata ctcgaaacag acaaaaggac aaatgcatct tgtttcaaag 472681 gaagatgcat ttgtccttgc atgcttattc ttatcaaatc ttacagaact cttctcataa 472741 taggttattt ttcttttttc ttcagcccga agaagaaagg aaaagcagaa ccgaccaaga 472801 aggtgccgaa taaaaacatg ccgccgataa acacgtggaa atttgtgtgt ccggccgtaa 472861 acgccgtgat tagggaaatg atactgagca cgatcatggc aatgccgggc gcgactctca 472921 tttttccctt ggatttatgg gcagcaacag aacataaaat gccgataaca ataggaacaa 472981 tccacaaata aaacagaata aatactgaca tcatcaaaac tccgattttt cttctatcat 473041 aacaaatttc tgtcaaaaag ggtatcaatg agcttttgcg gaaaaataaa aaccggcttt 473101 agaagccggt ttttttatcg aaacgtatct acaattaaaa acacattcaa agcaacgatc 473161 aatacagcaa tcagccaaga caccactgtg atccatttgg cgttgatcag agatcccatg 473221 atccgtttat tgcttgtaaa cataataagc ggaatgaggg caaaggcgat cccgaaggac 473281 agcacgacct ggctcagtac gagagcggtc gtcggattaa cacctgacgc gatgatcaag 473341 atcggcggaa tgatcgtgat aaaacgccgt acatacagcg gaatgcggta gttgataaat 473401 ccttgcataa tcacgtcgcc tgaaagtgtg ccgacagacg aactggatag accggcaacg 473461 agcagcccga tcccgaacaa agccgcagac atagggctga caagatgtcc gaattgctga 473521 aatgcgacgt cgagatcctc aacaaacagg ccgtttttga agaataatgc ggcagccaca 473581 atcagcatac ttgcattaat agcccctgca atcagcatcg ctattaaaat atcaataaat 473641 tcaaacctaa agattttttt ccgttctgca tcagttttgc caaccacccg ccgctgtgta 473701 agggcagagt gtaaataaat ggcgtgcggc ataacagttg cgccaagaat acccgctgca 473761 agaagcacac tgtcggtgcc atgaaacgcc gggacaaaaa ggcccttcat cactgacacg 473821 gcatcaggct ttgcgaaaaa ggtctgcaac gcaaaggcga tcacgaccac aaacagcata 473881 ccggcaatac ctgcttcaag tgagcgataa ccacggcgct gaagctccaa tatcgcgaaa 473941 gaaccgatcg ccgcaataat agacgcttca agcatcggaa tgccgaacag caaatacagt 474001 cccagagccg ctccgataaa ttccgccaga tcagttgcga taatgaccaa ctcgccctga 474061 atccataatc cgatcgagac aggcttcggg aattcttcac gggcaacctc aggcagattt 474121 ttgcctgtcg caataccgag tttggcggat agggattgaa ttaaaagcgc catgatattg 474181 gaaaataaga tcacccataa gagcatatat ccgtatttag aacccgccga aatattcgtt 474241 gcgaagttgc cgggatcaat ataggcaatg gctgctataa atgcagggcc gagaaaaggg 474301 agcagccctc tgaatcctct gattttcccg tcaagcgcat cttggacggc tttggaacgg 474361 ggagattgtg ctgtgatgtc cttgttcatc atgtctcacc tgaattctgt ttgtttttgc 474421 cgtacaacaa agagtttcct taaggcaaat tattttatct acatcatatg accatcccgg 474481 tttcttgtca accgaaaatg ttcaaaatac acttctgaat ttttccctgt tatgtaacat 474541 gatatgtagg gattcgtgat aaggtcccat ataaaaagac atcgtttcat ttcgaaacga 474601 tgcctcctgt atctaatgag tctaggcttc cttccgcagc ccgcggaata taaggcccag 474661 caagaacacg aagatggctg ccccgatgat ggccgggaaa atagcaaagc cggcgaggct 474721 cggtccccat gtgccaagaa gtccgtgccc aatccaagcg ccgatcagcc cggcaatcat 474781 agagccgaaa attcctcccg gcagccggtt tcctacaatg gcgctcccaa ttaatccgat 474841 aacaattgca acaactaatg aaaccaaaaa gctaagcatc atgatcacct ctcataaatg 474901 atttaccaat caataaccgc tcctgatcat ttcgaaacac ttgaaagcat attcctttat 474961 gatcctgttt taatctttct ctgcacactg ccgtcagcta aatgaacaat gacctcagtg 475021 cctttatgcg ccgcgatttc ctttgcccgt tcaatcgctt ctttctttgt atccttgatt 475081 tcagacacac gtttggcgcc ctcggctttg actgcccagc cttttttatg cttaataaca 475141 tgctctgctt tattcatgag ctcggggccg ctgccgctgc ttggatcagc atcgcgttct 475201 gtctcatcat catgcgtcag gaaatcatca atttcatctg tagaggcgtt ttccgcccat 475261 tccttcgctt tgcttgtcgc aattggaatc gcgcgccctt cctcatagcc ttcatcaatc 475321 atcgcattcg caatgtctat cgcctttttt ctcaccggct tctcaagatt ttttaatgaa 475381 gcaggataat ccttcatcga ccaaggcatg tctatcactc cttttccttt tataaaaatg 475441 gtacccgcag gtgaaaaata aaaacgcatc cgaaaaaatg aaggtatact atatagtaga 475501 aaaaacggaa gggaagtgcg ggttgggtgc caacagaacg aaaagaagac ttacatcagc 475561 aattaaaaga gatagagaaa tgggaaaaag atcagcaaaa agtctggttt tgggaaaagc 475621 tcagccgtct cccgtttcaa ctcctggaca agctgacacc agaattcatc cagaaaaaga 475681 tcggcaagct cttggatgag gtcggcagct ttgttcaaac aggcggacag tacctgacat 475741 ctgaaaaaca gattatcagg atgtttcaaa agaaactgcc ggaggagatc tttgaatcgc 475801 tggaggacat ccggaaagcg cctcttcctg tcatggatga aattgcggaa ggaatgggca 475861 aaaacagaac caacgcagca accgttcaag gcgcgacaac cggtgtgggc ggcgtgttta 475921 cgctggcggc agacattccg gcagtgcttg gcttatcact aaaaacatta caggatatcg 475981 cagtcgcata cggctatgac ccaaaggaga aaaaagaacg agtcttcatt gtgaaatgcc 476041 tgcagcttac gtcggctgat gttgtcggca aaagatcgat tttgcaggaa ttaaaacact 476101 acgatcaaga ccgtacatat aagaatgtcg cttctcaaat ccaaggctgg cgagaagtcg 476161 ttttgggcta tcgagacacg tttggctgga aaaaactttt ccagatagtg ccggttgccg 476221 gaatggtttt tggcgccgct gccaatcgct caacattaaa cgacattacc gagacaggca 476281 tgatgctgta caaaaagagg cgcattcttg aacgactgaa agaaacagaa cgagagatgg 476341 aatagcagaa agcagacgga caccgcgatc cgcctgcttt ttttagtgga aacataccca 476401 atgtgttttg tttgtttaaa agaattgtga gcgggaatac aacaaccaac accaattaaa 476461 ggaggaattc aaaatggcag acaataacaa aatgagcaga gaagaagcag gtagaaaagg 476521 cggagaaaca acaagcaaga accatgacaa agaattctat caagagattg gtcaaaaagg 476581 cggagaagcc actagcaaaa accatgacaa agaattctat caggaaatcg gcgaaaaagg 476641 cggagaagcc actagcaaga accatgacaa agagttctat caagaaatcg gtgaaaaagg 476701 cggagaagcc actagcgaaa atcatgacaa agaattctat caagaaatcg gccgaaaagg 476761 cggagaggca acaagcaaaa atcatgataa agaattctac caagaaattg gctcaaaagg 476821 cggaaacgcc cgcaacaacg actaatcaaa agcataaagg cagacaacct gtaaataaaa 476881 aagcgatccg gcacatcagc tggatcgctt ttttttggaa tcttctcaat ttatgccgct 476941 attgagatac aataagtgaa aaaggggttt tcgctaatgt ccaagatgca aaacttgctc 477001 gccatcgcaa atgaagtcaa agaaaagcac gccaattttt caatctcaga ggtcaacgac 477061 cactgcgtgc gccttgcggt gtttacggga gaatatgact ggcaccatca ccctgactca 477121 gacgaattgt ttattgttct tgaaggggag ctgctgatcg attttaagga caaagaaacc 477181 gcggtgctca aagcaaatga cagcctgctg atccctaaag gcacggttca ccgcacacgc 477241 tcttacgtca gaacggtaaa tctctgtgtg gagcataaac aagccgaaac cgtcatcata 477301 gaggagcagc catgctaatc aaaaagatga tatgtgaagt agatgctgca aacgctgaag 477361 catttgcaaa agcgcagtca cagtgggaag cgttatcgca tataagcggc tttatcaaac 477421 aggccggcgg ctggcgaaaa acgatagacg agccgctcac cgcagaaatc atcagtgtat 477481 gggaaaacag agaagcctat gatcatttta tggagaacga acatgacagc atatacgagg 477541 aaaacgatca gaaggctgta attctttcga tagaggtgac ggtgtacgaa gaggataaac 477601 cgttcgttca cgatctgtta cataaccccg atatccggta cgaaccaaac tggacggttc 477661 tgaaggcata atcaaagccc aaaacatcat gttttgggct tgtctcttta ctcgcgtccc 477721 ggaagtgtat tatgaacaaa aggcggtgct ggttttaact ccggtttttc tccaaacgtt 477781 tttgcttctt tcacatattc aaaggcttct ccgtccggcg ctttttcatt cagccagttt 477841 tgctcggcgc ttacttcgcc ttcagagaaa ttgataagct gatgtgagaa ctcttgtttt 477901 tcgagcgctt tcgggaatgt acccggcaca accggacctt cctgtgcttc taattcttta 477961 atggcggcga gccattggtt ctggtgcatc gtgtcacgcg ccagcaggaa gctgagcata 478021 tctttgacgc ctttgtcatc cgtcatttca aacaggcgtg cgacctgcag acggccctga 478081 gattccgcat tcaggttggc gcggaagtct gccagcaggt ttccgcttgc tacgatataa 478141 ccgccgctcc aaggtacgcc tgtactgctt tccggcatgg cgccaagtcc tgatacaatc 478201 gcatggtgag ggttcatgcc gcctaggatg gagccgatga ccggatcttc agcagctttt 478261 tcctgctgat caagaggggc atcctcaaga agtctggcaa tcatcgttgc gatcatttca 478321 acatgcccga gctcctcagt tgccgtatcc atcagcaagt ccttgtattt ttcatttcct 478381 cttgtgttcc agccttgaaa taagtactgc atggcaactg aaatttctcc gaattgcccg 478441 cctaaaattt cttgcatttt tttagcgaat aatggatctg gacgatctgg tttagcagga 478501 tgctgcagca tttttgtgtg cttaaacatg tacccatctc ctttttcgtt tatctctttt 478561 tatatttccg atcgatagaa agataaacga aaaacagcgt atcgagatgg gaactatgaa 478621 tcttttcgca gctccaacag ttcccggatc agctcccggc caaagatggg ctcatactgc 478681 cggtaaacag ggtcaagacg cttcatccat tcttgtttct ctttatctga cagctcataa 478741 atatgtatag cagaattctt tttgatttct tccagctgct ccttgttcat ttgttcggca 478801 tacgtttcat tccactccgt tgtctccttc atcgcttcag tcaaaatgcg tcttgtttct 478861 ggtgtttgcg ccttccagaa gtgttcatca gtcatgacag cgtagccgag ataaccgtgg 478921 ctgcttattg tcaaatagtc ctgaacatta taaaattttt tagaatagat gtttgaaatt 478981 gtattttctt cgccatcgac tacattgttt tctaacagct gaaaggtaga attgaaggat 479041 tcctgatgag gtgttgcgcc aagcagcttg aactgatcct caatcacatc gctttgcata 479101 atgcgcagat cctgcccttt taagtcatcc ggtgttttga ccggcccttg atttgttgtg 479161 atttgcttaa agccgttcgt ccaataggcc aatcctttca attggttttt ctttagagaa 479221 tcaaacagct gtgtgccgat gcttccgttc agcccttttt tgacggcgtt gtaatctgta 479281 aatgcatacg gcagatccag cactccccat tcaggcgaga gcatgccgag cttcgatgtg 479341 gagggggcga taaattgaac atcgccgttt tgcaatgctt caatttcttc aatgtccgag 479401 tacaggcttc cattcggaaa tacttctatt tttatttttc cgcctgattt ttcgttcacc 479461 agatcagcga atttattggc ggccagccct tttggcgtat tttcagcaac cacgtggctg 479521 aatttaaaca cgatttgatc ctgcaggcct tcctggtcgt catcataaac aatcttttta 479581 ttgccggtat gatcatggaa tccgataaat aaagcggttg caattccagc gatcatcagt 479641 gcgagacatg caagcaaact cttcatgaaa agccctcccc tatgttaagg ataatggggg 479701 ctatgacatt cgtaaagacc tgaaaggaga agctgatgaa caaaaagaag ctctcaatcc 479761 gttggaaaat cacgatctta tcctatatac tcgtcatttt ctcctttttg atcggcggca 479821 ttgtgctcat cggcaacatt cagcatacag aggagcggga gctgaaaaag cggctgatga 479881 atacggcccg gacggtgtca gagatgacag aagtgaaaga agccttggcg cgaaaaaaac 479941 aaacagaagc ggttcgccat gcggttgaag aaatcaggat gattaatgaa gcagactata 480001 ttgtcgtcat ggatatgaat cacatccgat atacgcatcc tgtcagcaca agcattggca 480061 agaaatcaga aggtgcagac gaggaggcag cttttgcgga gcacatttat ttctctgaag 480121 caaagggcga gatcggcacg gcggttcgcg ctttttatcc ggtaaaggat caagacctga 480181 accaaatagg cgtggtgctt gtcggaaaaa cgctgccggg gatcgctgac atcctgcttc 480241 atttaaagcg tgatatcgcc ttcatcgttg tgctgacact cggctttggc cttgctggtt 480301 cctttttgct ggcccgccat atcaaaaaac aaatgtttca gcttgaaccc catgagattg 480361 tccgaatgta tgaagaacgg acagcgacgt ttcactcgat gaatgaaggg gtgatcgcta 480421 ttgacaatcg tctcgtcatt acgatcttca atgaaaaagc gaaacagatc tttgaagtgc 480481 agggggatct aatcggcaag gtgatttggg aggttctcaa ggattcgcgc ctgcccgaaa 480541 tcgtggagcg gaacaaagcg gtttataatg aagaaattcg tgtcagcggt aaggtgatca 480601 tgagcagcag aattccgatc gtcatgaaga aaaaagtgat cggcgccgtt gcgatttttc 480661 aggacagaac ggaagcggcc aagatggcag aggaattgac tggtgtcaga aactttgtgg 480721 aggcgctccg tgtccaaaac catgagcata tgaataagct gcacacgatc gccggtctca 480781 tccagctggg gaaatctgaa aaagccttgc agcttgcatt ccaggcgtca actgagcagg 480841 aaaatgtgac tgaatttctg caccgctcga ttcaaaatga cgctgcggca ggccttctat 480901 taagtaaaat cagaagggga agagagctcg gcattgctgt tcatatagat gaaaacagca 480961 gtcttcagca atttcccgag catgttgatc agcatgatat tgtcgtgctt ttggggaatc 481021 tgattgaaaa tgccttcggc tcatttgaaa ccgttcaatc tgaagacaaa cgaattgaca 481081 ttagtatcga acaaacagat gatatccttg ctattttaat agaagataac ggctgcggaa 481141 ttgaaccgac acatatgcct cgcctttatg acaaaggttt tacggtcaat aaaactggcg 481201 gcacaggcta tggcctgtat ctagtgaaac aaatcataga caaaggatcg ggcacgatag 481261 aagttgattc acatgcgggg caggggacat ctttttctat cgtttttcca atgaaggggg 481321 aggaagcaca gcatggctcg taaagaatgg aaggttctgc tcattgaaga cgatccgatg 481381 gttcaagagg tcaataagga tttcattaca actgttaaag gcgttactgt ctgtgcaacg 481441 gcaggaaacg gagaggaagg catgaagctg attaaagaag aacagccaga tctcgtcatt 481501 ctcgatgtgt acatgccgaa aaaagacggc atcaagacct tgcaggagat cagaaagcaa 481561 aagcttgaag tggatgtcat tgtcgtctcc gctgcaaaag acaaggaaac gatctcactc 481621 atgctgcaaa acggggcggt tgactatatc ttaaagccgt ttaagcttga gcgaatgaga 481681 caggcactcg aaaagtacaa gcaatataaa caaaaaatcg aagcgaatga tacgctgtcc 481741 caggaacagc tcgatgcgat cctgaatatt ccgcagcagg ccgtacagga tctgccgaaa 481801 gggttgaatc acttcacgat gaatgaagtc actgcttttt tgaaacagca aaccgcatcc 481861 ctttctgctg aagaggttgc caaggcgctc ggcatcgcca gagtgacagc cagacgatat 481921 cttgattact tagaaaaaac cgggatcatc aaattggacg ttcaatacgg cggagtcggc 481981 cggccggtca accgctacgt gttaaaagga taaacctgag accaaaaaga ccaaaatgtc 482041 cgttatgatc ataaacttcc ccagactgta tgaaaacgct atcattctag taagaaagac 482101 acaaaaggcg aataggacag ggggatgaag gatatgaaac tgtttaaaaa tttaacagtt 482161 caggtcataa ccgcggtcat catcggggtc attgtcgggc tggtctggcc ggatgtcggc 482221 aaagaaatga aaccgcttgg tgatacattt atcaacgctg ttaaaatggt gatcgcacca 482281 atcattttct tcacaatcgt tctcgggatt gcaaaaatgg gcgatatgaa gaaggttgga 482341 aaagtagggg gaaaagcgtt tatctatttc gaggttgtca ccaccctcgc actcattatc 482401 ggtttatttg tcgtcaatat tatgaagccg ggtgcgggtc ttgattacag caagcttgaa 482461 aaaggagatg tatcacaata cacgcaaaat ggcggtcagg gaatcgactg gattgaattt 482521 attacacaca ttgttccgtc caacatggtt gatgccttcg caaaagggga cattttgcag 482581 gtcttattct tttctattct tttcggagtg ggtcttgcgg cattaggcga aaaaggaaaa 482641 agcgtcattg atttcttcga caaggtttct cacgtttttt tcaaaattat cggctacatt 482701 atgcgtgccg cgccaatcgg ggcattcggg gcgatggcgt atacaatcgg acacttcggg 482761 ctcgattcca tcaaaccgct ggcaagctta atgatgtctg tttatattac gatgttcctg 482821 ttcgtatttg ttgctttaaa tatcatctgc aagctttacg gattcagcct gtggaattac 482881 cttcgcttca ttaaggatga gcttttgatc gtgcttggca caagctcttc cgaatcggtg 482941 cttccgcgta tgatggataa aatggagcgc tacggctgtt ccaaatccgt tgtcgggctt 483001 gttattccga cgggctattc gtttaacctc gacggcacat ccatctattt atcaatggcg 483061 actgtctttt tggcacaggt gtttggagta gacctcagca tcggccagca aattacgatt 483121 atcctcgttc tgatgctgac atcgaaggga gcggcaggtg tgacgggaag cggatttatc 483181 gtccttgcct caacgctgtc agcgctgcag gtcattccgc tggaggggct tgcactcctg 483241 ctcggggtcg accgtttcat gagtgaagga agagccattg tgaacctgat cggaaacgga 483301 atcgccacga tcattgttgc caaaagcgaa aatgaatttg atgaagcaaa aagcatagag 483361 gctgttgaag gcatgaaaaa aatgaaaaca gcagtctgaa aaaagaacgg cccatccatg 483421 ggccgttttt ttaattgttt aagaattatt aaggtaagga cagagacctc agcatttttt 483481 tgttatataa tttacaaatg gatactatat tgaatgaagg acgtttgtcc taacaggagt 483541 gtataaatgg ccgctttagt taaatttttt cagcacccgg gagtaaggcg tttctccatc 483601 tttgtcgtgt taactggtgt gttatatcta tttaagagca tgatcaactt aatattgctt 483661 accttcattt tcacatttct aatggatcgt ttggagcttg tcgtgcggca gtttgtaagc 483721 cagttcttcc gcgtgagcca gcgggttgtc attacgtttc tttacatgtt gctggctgtg 483781 ctgcttacag tcgggggctt tgtgttttat ccggtcgtcg cggcgcagat ccagcagctg 483841 gtaaagcaga ttaaacatat tgcgtatcat cctgacagca tccctttctt tgatgagatc 483901 accagtgtct tcggagatat taacatcagt tcatatgtca aagagggctt caatgtagtg 483961 tatacgtatc tggccgatat cagcacattc ggcttgcagg tcgtgatggc gctcattctt 484021 agcatgtttt tcttatttga gaaaaaacgg ctttctgaat tcatggcgaa atttaaaacg 484081 agcaaactta gggtctttta tgaggagatt gcttttttcg gaagcaaatt tgcaagaacg 484141 ttcggcaagg tgctcgaggc tcaatttatc attgcgctcg tcaactgtat tctgacgttt 484201 atcgcgcttt ggattatgca ttttccgcag ctgtttgggc tttcgattat ggtgttcttc 484261 cttggattga tccctgtagc aggcgtcgtc atttccctga ttccgctcag cattatcgcc 484321 tacagcactg gcggtggaat gtatgtgctc tacattgtcc ttgtcatatt cgccattcat 484381 gcgatcgaaa cctatttctt aaatccgaag ctgatgtcgg cgaaaacaga gctgccaatc 484441 tttttcacct tcacagtact cattttctct gaacacttct tcggcatttg gggtttaatt 484501 atcgggattc cgatctttgt gtttctcctt gatattctgg atgtcaccaa caaggaagat 484561 aggtctaaag gaccccgaga gaatagcgat aaaaagtagt ttaaaatcga ataatgagtg 484621 tgcctcgatc tgccggcctg cctgttcagg gcatggaatt aagactcgga atcggagctt 484681 ggcattgcct tgcacagtgg tgaacacaac aggtgacaat gcttgtcatc agtacggaaa 484741 ctgaaaagaa caaacagtcg gagcaaacgc tcatcatcgg tttaaccaaa catttggaag 484801 caacaaatgc tataatacaa acagtgccta atgttgggca ctgtttattt tttgtcgaaa 484861 aaggaggaag gctttatggc tgagccgatt ttacatattg aaggcctcga taaaaaaatt 484921 gggtctaaac agattttaaa acagatcagc atggacgtca tggagggtga aatcatcggc 484981 cttctcggtc cgaatggttc cggaaaaaca acactcatcc gtatcatcgt cgggctgttg 485041 aaacaaaaca gcggaagcgt gacaatcagc ggattccagc atgatacaga gtttgaaaaa 485101 gcgatggaag cggttggagc gattgttgag aaccctgagt tctatccgta cctgacaggc 485161 tgggaaaacc tcaagcactt tgcgaatatg cacaaaaaaa tagcggatga acggcttgat 485221 gaagtggtgg aacgtgtcgg gctgacgtca gcgattcatg ataaggtgaa aacctattcc 485281 cttgggatgc gccagcgtct gggaatcgcc caggcaattc ttcaccggcc gaagcttctc 485341 attctagatg aaccgacaaa cggcctcgat cctgcgggga tgaaggattt tcgggatcat 485401 attaaggaac tcgcagaaat ggaaggaaca gctgtcctgt tcgccactca tttattgcgc 485461 gaggttgaag acttgtgcga ccgtgtcatc atcattcaaa aaggtgagat caaagcggaa 485521 gtcagcttac aaggaaccga tcaaaccaca gaaaaagcga ttatagaagt gcagccgcaa 485581 gaaaaagcgc tcaattggct gacaggcaat caatatcaag ctgagagcca agacgggacg 485641 attgtagttg aggtggcaaa agaaaacata ccggagctga accgatcact tgtcggacaa 485701 gatctgaatg tattttccat tacgccttac acgcagtcac tggaagacga atttataaaa 485761 gcgacaacag ctcatcaaga ggagggagaa gagcttgtct aaattaattt ggaatgaaca 485821 tatgaaactt tttaatcgga aggtcacttt ggtttctctt atcctgatgg ctgtctttca 485881 attcttcatg gcattgatca ttaaacggat tgtcatcagt gccggaacag atgaaaactt 485941 catcggctat ttatcgtata caccgagcct gaacattttg ctgcaggctt taacgatcgt 486001 aattgcagca acaattgttt cgatggaatt tgataaaaag acgatcaaat ttttgctcat 486061 tcgtccggtt aaacgccaaa aggtcttttg gtcaaaatta atcacagtcg tgatggtcag 486121 cttctatttg tatttggcat actacattct ggcattatta ttcggtctct tgttttttgg 486181 cacatcggtg actgcggaat caaagacatt gctggtcaac accttggcgc tgatcgggtc 486241 aaactggctt gaagctgtaa tgatgggatt attcgggctg ctttgttctt cgctgttccg 486301 caatagcgcg gtagcagttg ttgtttcttt tgtcgtttta tacggagcga gtacacttgt 486361 tcagctcatg aagttgtttg aaaacaagtg gggcagcttt ttgctttttg cgaacactga 486421 ctttacgcaa tacagaagcg gagagacagc gttgttttca ggcatgacgc cattgttttc 486481 aattggaatt ctcatcatac atgccatatt cttcatcgtt gttggctggt ggtgcttctg 486541 taaacgggat gttcgggtct aaaggcaagg aatgacattt ttgtgaaaaa gctcacgtaa 486601 atcaatatca tttgatattt tggtttatac taaaggtact gacggaggtg tctcgattga 486661 ggaactttat taccgcttta ccgatcgtat tgctgcttgg attctcattt gtgtcattca 486721 tgtttcagtt tgaacatctt gtttatttca ggctcgcgct tgggttgttt tctctcgtgg 486781 gactgtacat gatatataaa atgaagacgg gcatccgcta ttttatcatc tatctgtatg 486841 ccagctggat tgtgttggcc gcagtgaccg cttttgaaga gccgattttc tcaagctttt 486901 tctttggcgg cctggtgatg acgatgggtt acctgacata tatgctgatt tatctcggca 486961 tgaaacaaga ccgggatgca aatcctgtgt aatcgcgctg ttcccttggg gaacggcgtg 487021 tttttctata ctgggcaaaa ggttaacagt tgcggaaaaa tggcaggaaa tctataatac 487081 atattaaatt tatcggaatt aaaactgggg ggctgccgga tgtcattatt tatacaaaac 487141 gatcaacagc ggcaatggat ggagaaaatc ggacggattg cggatgaatt tcagcaaaca 487201 gctgctgaag atgacgaaca gggacgtttt cctgcagaga aaatacaaaa actgcgtgat 487261 gctgggtata cagcattaac attgccggca tctcatggcg gagggggcat ttctgtttac 487321 gatatgctct tgtttcaaga acggcttgca cggggagatg ctccgacggc tcttagcatc 487381 ggctggcatt tgagcgtgat cggggagctt ggagaaggca acagctggga tgaagacgta 487441 tttgcatttg ttgccaagga agtccaaaac ggagccgtca ttaacagggc ggcgactgaa 487501 gcgaaaaccg gaagcccgac aagaggaggg cgtcccggta cacacgccgt caaaaaggat 487561 ggcaaatggg cagtgaacgg gagaaaaacc tttacgacga tgtcacaagc tctggattat 487621 tttttagtaa ccgcatggat tgaggacaaa caaacaacag gcgtgtttct cattcataaa 487681 gatgatcccg gcttgtcgat tgaagaaacg tgggatatga tggcgatgcg ggcgactggg 487741 agccatgacc ttgtactgaa cgaagtaatg cttgatgaga ataagctggt ggaactgctt 487801 caagggcctc gtggagctaa gccgaatggc tggctgcttc acattcctgc gatttatctt 487861 ggtgtggctc aagctgctcg tgactatgca gtgcaatttg catctgagta ttctccaaac 487921 agcttgaatg gaccgatcaa gaatgtcccg gccgtacagc aaagaacagg cgaaatggag 487981 cttgaactgc tcaatgccag acactttctt ttccatatcg ctcaattgta tgacgatccg 488041 gtgcggcgtc cacacttgac cagcgagctc ggtgcggcga aacatatcgt cacaaacgct 488101 gcgctgtctg ttgttgataa agcgatgaga attgtcgggg ccaaaagcct ggaacgaacc 488161 aacccgcttc agcgctatta ccgtgatgtg cgcgccggtc ttcacaaccc gccgatggat 488221 gacgccgtga tacacaagct ggcagctgaa gcgtttgagt cataaaaaaa agagccttac 488281 cggctctttt tatgtattgt tttgctcttg cagatttttt tgatgcttgc ggtcgatcct 488341 gtcataaata acgttcatca gctttggatt gcccataatc gcctctttgt tttcctggat 488401 cagctgttgg taagttttca ctttacgctt cggcatgctc cggcgccctc ctgacatgtt 488461 tgtattcact ttctaactcc gtcagcgaca attcatacag atgacgcttt gactttttgt 488521 atataccatt ctgtattaac agatgaatga gctgtttttt tctgatttct gcagactgag 488581 gtgtcattgt gtcaccaacc tccaatcaaa cgatattgat aatcattatc aattaacttc 488641 agtatacaat gtccgcaata gcctgtaaag atgaaaagag tcctattctt ggccaattta 488701 caaacattca acaaatcgac aaaaagtttc ccgggcaata atttgctgtc gaaatattcc 488761 gcttcattga acgcaccctg ctatttttca tgttttgaac catactatgt aatagaatgg 488821 aggctggtat tcaatggagc ggacagaaaa tctgaaaaag ggagaaaaag gggcgctcct 488881 caatattttt gcatatgtca tccttgctgt tgtaaagcta gttatcggga ttctatatca 488941 ttctgaagcg ctgagagcag acgggttaaa taatggaaca gatattgttg cgtcagtagc 489001 agtgctgata ggattgcgga tttctcaaag accggctgac agcgatcatc catacggcca 489061 ttatcgggct gaaacaattt cgtctcttgt tgcgtctttt attatgatgg cagtcggcat 489121 tgaagtgtta atcggcggag gaaaagcgat tgcgggcggc acaacggaaa cgccaaatct 489181 tatcgcggca tggacggcgt taggcagtgc tgtgtttatg tatggcatct atttatataa 489241 caaaaggctg gcagcgtcca ttaaaagctc tgccctgatg gcagcggcaa aggacagcag 489301 gtcagacgct tttgtaagtg ccggcgcgtt tatcggtgtt ttttcgtccc agctgaagct 489361 gccgtgggtt gatccggtaa cggcttttat catcggcatc atcatttgca aaactgcgtg 489421 ggatatcttt aaagacgctt cacattcctt aacagacggc ttccatttaa aagatcttga 489481 gccttacaaa cagaccgtcg gcaggatcga aaatgtgcat cgcctaaagg atgtgaaagc 489541 gaggtattta ggcagtacag ttcatatcga gatggtgatt acggttgatc cgaagcttac 489601 agtagaagaa ggccatggag tggcggatga agtagaagac aaaataaaac atgaacacga 489661 tgtcactcat gttcatgttc atgtagagcc tgacgacata aaataaggct gtttaacgaa 489721 ttagcttata tgttcagata aaaattcagt cacttcttca ggcgttttgg cattggcgct 489781 gtgaaggtga gctgtttttt caccgttctt gaaaataagc aggctgggaa tgcccattac 489841 ttggtatttt tcagccaggt caggaagctc gtccttattc agctcatacc agtcgttttg 489901 gttgtattct tccaaaatat cgccgatgaa catattcatg cgtgtgcagt ctgggcacca 489961 atcagcataa aactttacaa tgatttcttt atcagattga atcagttcat taaattgttc 490021 gtttgttgtg atttttttca tatgtcacat ctccttttca atgccatttt aatataaaat 490081 aaaaaggaat tacatacaaa tgcattcaac atcagcatgc ccaaaaataa ttagatcatt 490141 ttccggtgaa aatgataaga tagtaaagat gaattgtagt ggggggagta tccattgaaa 490201 acaagtctag gattagtgta cggaggaaag tcggcagaac ataatgtttc cctgcagaca 490261 gctctggctg taatcaaagc gctaaatact gagaagtttg atatacatcc gatttatata 490321 acagaaaaag gcgaatgggt tagaggcgcc cgtttaactg aacctgtttc aaacgtgaaa 490381 atgcttcaat ttgagcaagg aggcagtgct ttttctccag ctgccctgaa ccaggagatg 490441 tttccgcagg aagcgtcaca gcaaaatgaa gccatcgacg tcgtattccc gctcctccac 490501 ggaccgaacg gagaagacgg tacgatccag ggaatgctcg agctgttgaa cattccttat 490561 gtcggcaacg gagtgcttgc ttcctcagct ggcatggata aagttgtcat gaaacattta 490621 tttgcgcagg ttggccttgc tcaggctaaa tacgcagctt tccttaagaa agactggact 490681 cgttctccga aagaaagctg tgaggaggtt gaacaggaat taggctaccc ttgcttcgta 490741 aaaccggcga acctcggctc aagtgtcgga atcagcaaat gccgaaaccg tgaagaactg 490801 caaaaagcgt ttgagcttgc tttccaatat gaccgcaaag tcgtcgttga agaaggaatt 490861 aacggccgcg agatcgaaat cggcgttctt ggaaatgatg atcctaaatg ctctgttgtg 490921 ggagaaatcg caccgaagac agatttctac gattacaaag cgaaatatga ggatggagat 490981 actgatctga tgattccggc gattgtgact gatgaggaat acgcaacaat cagtgatatg 491041 gcgatcaaag cgtttaaagc gatcgacggt tcaggactcg tcagagcgga ctttttcctg 491101 acagctgacg gcgaagttct gatcaatgaa gtcaacacaa tgcctggctt tacacctttc 491161 agcatgttcc cgttgctctg gaaagaagcc ggagtggaat atgctgacct gattgaacag 491221 cttgtggagc ttgcaaaaga acgccacgct gaaaaacaat tgattaagca tacattctaa 491281 tgaagaagga cactgccggt aaaagggcag tgttttttcc cgtatataca aaagaaagag 491341 agggacctta cttgattaag cgaacagtaa aaaacattgc cgaaatggtt aaaggcacac 491401 tagcaaatcc gcaatatgaa caaacagtca ttcatggagt ggcaaccgat acaagaaaac 491461 tggaacaaca tcagctcttt attccgctga aaggggaacg ttttgacggc cactcttttg 491521 tggagcaggc ctttgaagct ggtgtagcgg ctgttctttg ggatcggtca gtaccaaatc 491581 cgcccgagaa tcacgccgtc attttagtgg acgataccct tactgcactt cagcagcttg 491641 caaaagctta tttgcaggag cttggcacgc gtgtcatcgg agtaaccgga agcaatggca 491701 aaacgacaac aaaagatatg attcacgccg tattggggac ccagtaccgt gtccacaaaa 491761 ctggaggaaa cttcaataat catatcggtt tgccgctgac ggttttagcg atgcctgaaa 491821 atacggagat cgccgtattg gagatgggaa tgagcgccaa aggagaaatt gacctcttga 491881 gccgactggc aaacccggat gcggcagtga ttacgaatat cggcgaatcg catatgcaag 491941 acctcggctc tagagagggc atcgcggagg cgaagcttga aatcataaac gggcttaaag 492001 aagacggagt gctgatttat atcggggacg aaccgcttct tcaaaatgca tacagctgcc 492061 agacgaaaac gtacggtacg ggaacgcata atgattatca gcttcaggat gtcagccaga 492121 gtgaggaagg aacccatttt acaatcaaag ggatagaaaa cacgtttttt attccaatac 492181 tcggcaagca caatgtgatg aacgccatgg ctgcaattgc tgcaggggct tattttggca 492241 tcgcgcctga ggatgcggca aaaggactga gcggcctaaa ggtaaccggg atgaggcttg 492301 aactcatcaa aacagacagc ggcctttcga taatcaatga cgcttataat gcgagcccga 492361 cttccatgaa agctgcaatt caattgacag aaagccttga aggctacggc aaaaaaatgc 492421 tcgtgctcgg tgatatgctt gaactcggcg atcttgaaga aacgttccat aaagagtgcg 492481 gcgctgtgat cagccctgat aaaattgacc gcgtctttac gtacggaaaa ctgggagctt 492541 ttatcgcgga aggcgccctg aaacactttg agaaagaccg cgtcagccat tacactgaga 492601 aaaaagatct ccttcaagct gtgaaggaaa acgcatcaaa aggcgatttg attttattca 492661 aagcgtccag aggtatgaag cttgaagaaa tcgttaaaga tttaatagag agcccgcttt 492721 cataagaaaa tattttgcga aaaaacgcat attgcatcat aaaataacct gatatgcaaa 492781 cactaatgta tgccggccga aaattatgta tatctggccg gctgcggcta tgatacaata 492841 tatataggtt atttcgcgat acgaacatat tcgtccggac ttttcatcgt gacccgaagt 492901 tctccgctgg attcttggga gcggatggag cagcagccgg catattcgag atgccgatct 492961 gcttctcatc ttattgaaaa acaaatagtg taatggtaag ataaaactta aagtaattcg 493021 ggctttgtat acggatggat cctgtccttc ttgtctaaag ggcagtttta taagtggtaa 493081 atcacgacat tactgaaaca gcaattagaa ggagtttgaa taatttgact ataacgtttc 493141 aagattttaa tttaagttct gatctcatga aagcaattaa tcgtatggga tttgaagaag 493201 caacaccgat tcaggcacaa acgataccgc tcggactttc aaataaagac gtcattggac 493261 aagcgcaaac aggtacaggt aaaacagctg cgtttggtat accccttgtt gaaaaaatta 493321 accccgagtc tcctaatatt caagcaatcg taatcgcgcc aacccgtgaa ttagccattc 493381 aagtatctga agaattgtat aaaatcggac aagataaacg tgcgaaggtt cttcctattt 493441 acggcggaca ggatattgga cggcaaatcc gggcgttaaa gaagaatccg aatattattg 493501 tcggaacacc tggacgtctt cttgaccaca tcaaccgccg caccattcgt ttaaacaatg 493561 taaataccgt tgtaatggat gaagcggatg aaatgctgaa catgggattc attgacgata 493621 ttgaatctat cctttcaaac gtgccaagcg agcatcagac acttctgttc tctgccacaa 493681 tgcctgcgcc gatcaaacgc attgcagagc gcttcatgac tgagccggaa cacgtaaaag 493741 taaaagcgaa agaaatgacg gtttctaaca ttcagcagtt ctatttggaa gtgcaagaac 493801 gtaaaaaatt cgatacactg actcgccttc ttgatattca gtctcctgag cttgcgatcg 493861 tattcggacg tacaaaacgc cgtgtcgatg agctggctga agctctgaac cttcgcggat 493921 atgcagctga aggtattcac ggtgacttaa cgcaggcgaa acgtatggtt gcgcttcgta 493981 aatttaaaga aggcgcaatc gaagttctag tcgcaactga tgttgccgct cgcggacttg 494041 atatctcagg tgttacacac gtatacaact tcgacgtgcc tcaagatcct gaaagctacg 494101 ttcaccgtat cggaagaacg ggccgtgcag gaaaaacagg tatggcgatg acgttcatta 494161 caccgcgtga gaaaagcatg cttcgcgcaa ttgaacaaac aacaaaacgc aaaatggacc 494221 gcatgaagga gcctacactt gatgaagcgt tagaaggtca gcaacaggtt actgttgaac 494281 gtcttcgcac aacaatcagt gaaaacaacc tgaacttcta catgacagcg gcagctgagc 494341 tgcttgaaga tcatgatgca gtaacagtgg ttgcggcggc tatcaaaatg gctacaaaag 494401 agccagacga cacaccggtt cgcttaacag acgaagcgcc gatggtcagc aaacgctaca 494461 agaaccagcg ctcttctaaa cgcagagacg gtcaaggcgg cggctaccgc ggcggaaaag 494521 ggaaaagcaa caaccgttct tcctatgaca aaaagcgttc aaacgatcgc cgttcttcag 494581 gtgacagacg ccagaaaaaa tcttactaat ttgatcgatt cagagcccaa aacatgatgt 494641 tttgggcttt tttatgttcg tgatttgtta ttcagcaaac tttcagctga cggaagccat 494701 ttttctctgt atgcttaaga atgaaacctt tctgtaaaag agacgtataa ataacgacga 494761 aaaaaaggga ggtaggtatt tttgagagag cagccaaaaa accaaatcag tccagacgga 494821 ttaaaggttt ggcgacttca agagatcatc atatccgctg tttgcttgct tattgtcatt 494881 gcagttgcag tgttaagcta ttattttcat tggccgtact ggatcagcgg cgtgctcggc 494941 gctgtttggc tgctgggatc gattgtgacg gtctttatca ttccgaaggt ccgtcataag 495001 gtgtggcgat atgaagtcca tgaacatgaa atagatattc agtcaggtat ttttgtggtg 495061 acacgtgtga ttgttccgat ggtcagagtt cagcacgtcg atacgtcaca agggccatta 495121 ttaaaaaaat acaacctggc aacggtgaaa atttccacag ccgcgaccgt tcattcgatc 495181 cccgctttag agatggagga agcggatcgg ctaagagact ccatttcccg tctggcgagg 495241 gtgactgacg atgatgtctg aaccgaaacg cctgcacccg gtggcagtca ttttgaattt 495301 atgccatacc attattcaaa cgataaaaaa tatcattctg ccattctttt ttgtgtatat 495361 tgtcaattca aaccatactg tccgttttta cggagccatt gcgctcggtg tgctgttcat 495421 ctggcttgta gcggcaagca ttatcaaatg gagaaggttt acctatcgaa ttgaagatga 495481 tgaatttaga attgaagaag gcttatttgt tacgaaaaaa cgatacatat cgattgatcg 495541 gattcaaaca atgaatacga gcgcgggcct tgtccagcaa atctttaagc ttgtgaagct 495601 gcaaattgaa acagcaggcg gaggcaagga ggcagaagcc gttctttctg ctatttctgt 495661 tgaagaagcg gaacgcatca aagaagctgt ctttaagaaa aaagcgcaaa gacgagaaaa 495721 tgaacttgat gaagaacggc ttgaagctga agaggagttg gatccgtccg ttgaggtgca 495781 agagcactat cgcatgaacg cgaaagaatt gctcatggcc gcttctacct ccggcggaat 495841 cggagtcatt atctccgctg tatttgcact tatttcccag cttgatgaag tgctgccgat 495901 ggattggtta ttcgataaat tttccttcct tcagcacgcc agcatcggta tttatgcggt 495961 actcattttt atcggtttat ttatcgcctg gattttcagc atcgcgggca tgatgtttag 496021 atacgcgaac tttcaaatca taaaaaaaga gcaggaactg gtgatttcaa ggggaattat 496081 tgaaaaacat caagtcacga ttccgctgcg aaaaatacaa gccattaaaa tcaaagaaaa 496141 tatcattcgc cagcttttcg gctttgtaac ggtgtccatc gtcagcgcag gaggcggcga 496201 ccgggaaaaa gaagaaggcg ctttgaccat tctctttcca atgattcata aaaaaaagct 496261 tccgcacatg ctccgaacat ttacgccgga atacacgctg gaagaaaact gccgccgcct 496321 gccgcggcgc gcgttgaaac gctatttgtt ccgttctgtc attttttcac tctttttgat 496381 catcccgtta tgtatcttct ttcagccatg gggctatctg tcagtgatcc tgctgccgat 496441 agaattgctc ttcggctatc tcgcgtataa agaggctgca tggacgatca acggggaccg 496501 tcttcagctg acgtctagat ttataggcag aacaaccgcc attgtactga aaaaacgaat 496561 gcaggtctgc aagttcagcc aatcctattt ccaaaagaaa ggccgcttgt ataccatttc 496621 tacttcggtg aaatcatcga gccatatgga agagttaacg gtgagggacg taggtgaaga 496681 ggatgcagcc ttcattttaa agtggtactc atatgaaaaa gcggacggtt aataccgccg 496741 ctccagcgtg tcggcaaacc ctcgcattcg ttgtcaggac tgcgcttcgg tgctcaatgc 496801 gaagtggatc aacggctaaa ttctcaggcg tcctgcctaa acgccgtcgt catcacatcc 496861 tgtgaaagtc cgctcctatg ctcgtccttc ctagacttca tgggttttca atcacgctga 496921 aaagatgaca aaatcctaaa atgaaaacca ttttaggatt ttgtcaacaa tctgaagcgg 496981 cggttaatac cgccgctctt ttttttgcac gcataaaaac gaaagaagaa acccgccgca 497041 tagtccaaac aaatgggcca tcatgttaat attggagttg ataaacgaca tgagaacggc 497101 aaatgcgagc agtgtgatga tcattttgga atgctcctgc ccaattaact cattgcgaaa 497161 aagaaccata aacaggtata cgccaaatag cccgaaaatg gcgcctgaag ccccgacatg 497221 cacgtaatca agcggctctg taacataagt gccgatattg ccgatgatgc cggagccggc 497281 gtatacaaga aggaaacgcg cttttcccag catgcgttcc aaagccgggg caaataaaaa 497341 gatggacatg gaattaaaca gcagatgtgt gaaaccggcg tgcagcaaaa tcggtgtgat 497401 aagccgccac cattcaccgt ttgcgacacc tagattatag cctgtgacgg tatccctcca 497461 taacacgact gaatgggcag gaagtgaaaa aaacagccag agaacagctt gcaaagccaa 497521 tataaaggtg acaacggggt aaagcctgat aaatgtttga aaattttcag tccgtataaa 497581 cattccgagc cccttttctt cattttggta tatctatagt aacacgttta tgagacaaac 497641 catttaaata gtacgtacgc aaaggaggtt atcatacatg atttacggca ttgggctgga 497701 cattaccgag cttaaacgga tcgcctctat ggctgggcgc cagaaaaggt ttgccgagcg 497761 gattttgacg cgaagcgagc ttgaccaata ctatgagctt tcagagaaaa gaaaaaacga 497821 atttctcgcg ggcagattcg cggcaaaaga agcgttctcg aaagcatttg gcaccggcat 497881 tgggaggcag ctcagctttc aggacattga aattaggaaa gaccaaaatg gcaagcccta 497941 tatcatttgt acgaaactga gccaggccgc cgttcacgta tcgatcactc atacaaaaga 498001 atacgctgcc gcgcaggttg tgattgaaag gttgtcaagc tagtctgcat attagggaaa 498061 ccccactcat atatttgata gtgcattaag ggagacaagt tgtttgaggc ttttatggta 498121 cgcatctgtt ctgcctaaac gtgtaccgag cgtaccgtta aagtcaaaca agcgatttct 498181 tccttttaca tcaattgaga aaaaggggtt gaaaaaggtg agaaaaagct ttgttttgct 498241 tttaacggga ctgcttgctg ttcttattct ttctgcctgc gggcaaaaaa cacagcaaga 498301 tattgtggcc gggttagatg aaaaggcgaa agaatacacc tcgtacaaag caaaagcgaa 498361 aatgaccatc gagacaggga gtgagcctca agtatacaat gtggaaatct ggcacaaaaa 498421 gccgtctctg tacagggttt atttagaaaa tccgaaaaag gaccaaaacc aagtcatttt 498481 acgaaatgaa aacggagtat tcgttctcac gccgtcttta aataagagct tcagatttca 498541 aagcgattgg ccgaacaaca gcagccaggt ttatctgttt gaatcgctcg taaaggatgt 498601 tcaaaacgat tcggatgcag ttttcacagc gaaagaaaag aaatacgtat ttgaaacaaa 498661 aacaaactat cagcataaca aaatgctgcc cacgcaagaa atcacattta acaaaaaaga 498721 tatgagcccg tcatctgtca aagtgatgga tactgaccgg aaagtgatgg tcaaagtaga 498781 attcagcagc tttgaattta ataaacaatt tgataaagaa tcatttgatg aaaagaaaaa 498841 tatgaccctt tctcaaatgg atgtcgccac aagcgcaaag ccttccgata catttgcggt 498901 caaaacgccg ctggaactgc cgcttggcgt caagctgctt gaagaaaaag atatatctac 498961 tgaagacggg aagcgcatca tcatgacgta cggaggagaa aaatcattta cgttaattca 499021 ggaaaaagcc cagattgcca aggcttcctc ctccgttacg ctgaacggcg aaccggtaaa 499081 tctcggctac accatcggcg ccctgtcgga tgcatcatta tcatggacat atgacggcgt 499141 agattacctt ctctcttcta aagatctttc taaagaggaa atggtgacag tagcgaaaag 499201 catgcaggga caatcatcga aataaccgcc aaaggccaaa catgatttgg cctttttttc 499261 gttagacatc gtttcccttt agcctttaat tttagtatga tatgtaaatg atattgaata 499321 aaagctagga agtgtcgtaa tgagcacaaa acctttttac agagatacgt gggcggaaat 499381 tgacttgtcc gcgataaagg aaaatgtcag caatatgaaa aaacatatcg gtgaacatgt 499441 ccacttgatg gcagttgtga aagcaaacgc ctacgggcat ggtgatgcag aaacagcaaa 499501 ggctgctctt gacgcaggtg cttcatgctt ggccgtggcc attttggatg aagcgatttc 499561 actgcgcaaa aagggattga aggcgcctat attggtgctt ggcgcggttc ccccggagta 499621 tgtggcaatc gctgctgagt atgacgtgac cttaacaggt tattctgttg aatggcttca 499681 ggaggcagcc cgccacacga aaaaaggttc tcttcatttt catctgaagg tcgatacggg 499741 gatgaacaga cttggtgtaa aaacagagga agaagttcag aacgtgatgg caattcttga 499801 ccgcaaccct cgtttaaagt gcaaaggggt atttacccat tttgcgacag cggatgaaaa 499861 agaaagaggc tatttcttaa tgcagtttga gcgctttaaa gagctgattg ctccgctgcc 499921 gttaaagaat ctaatggtcc actgcgcgaa cagcgccgct ggactccggc tgaaaaaagg 499981 cttttttaat gcagtcagat tcggcatcgg catgtatggc cttcgcccgt ctgctgacat 500041 gtcggacgag ataccgtttc agctgcgtcc ggcatttacc ctgcattcga cactgtcaca 500101 tgtcaaactg atcagaaaag gcgagagcgt cagctacgga gccgagtaca cagcggaaaa 500161 agacacatgg atcgggacgg tgcctgtagg ctatgcggac ggctggctcc gaaaattgaa 500221 agggaccgac atccttgtga agggaaaacg cctgaaaatt gccggccgaa tttgcatgga 500281 ccaatttatg gtggagctgg atcaggaata tccgccgggc acaaaagtca cattaatagg 500341 ccggcagggg gatgaatata tttccatgga tgagattgca ggaaggctcg aaaccattaa 500401 ctatgaggtg gcctgtacaa taagttcccg tgttccccgt atgtttttgg aaaatgggag 500461 tataatggaa gtaagaaatc ctttattgca ggtaaatata agcaattaac ttacctaaat 500521 ggagaattca taaaacagct ttgcttgaag agtgaataat ggtatcatta tcactggatg 500581 gataaaagag tcgtatccgt aagtttggtg gaggtgtatg ttttttgtct gaatccagcg 500641 caagaaccga aatgaaaatc agcttgcccg aaaacctagt agctgaattg gatggtgtag 500701 cgatgcggga gaaacgaagc agaaacgaac tgatatcaca agcagtgaga gcgtatgtca 500761 gcgaacgaac aactcgtcac aaccgtgatt tgatgagacg cggctatatg gaaatggcga 500821 aaatcaacct gaatatttct tctgaggctc actttgcgga gtgcgaggct gaaacgacag 500881 ttgagcgctt agtcagcgga ggataatcat ttgattgtga aacgcggcga tgtttatttt 500941 gctgatttat ctcctgttgt tggctcagag caaggcgggg tgcgcccggt tttagtgatc 501001 caaaatgaca tcggaaatcg cttcagccca actgctattg ttgcagccat aacagcacaa 501061 atacagaaag cgaaattacc aacccacgtc gaaatcgatg caaaacgcta cggttttgaa 501121 agagattccg ttattttgct ggagcaaatt cggacgattg acaagcaaag gttaacggat 501181 aagattactc atctggatga tgaaatgatg gataaggttg atgaagcctt acaaatcagt 501241 ttggcactca ttgattttta gacatatttg caggttgctc aaatagagca actttttttg 501301 ttttcaaaaa acataaacga tataatagtg aaataacgaa aaaatatgtt gttttttatt 501361 gggaggtaag cgaatttgat gtcgaaccag actgtatacc agttcattgc cgaaaatcaa 501421 aatgaactgc tccaactgtg gactgacaca ctaaaagaat taagcgagca agaatcctat 501481 cagctgactg accaagtgta tgaaaatata tctaaagaat atatcgacat tctgctgctg 501541 tctgttaagg acgaaaatgc tgctgaaagc caaatcagcg aactggcgct tcgagcggtc 501601 caaatcggac tgtctatgaa gtttttggct actgcacttg ccgaattctg gaagcgtctc 501661 tacacgaaaa tgaatgataa gagattgcca gatcaagaga gcacggaatt aatctggcag 501721 attgatcgct ttttcagccc gattaacaca gaaattttta atcaatactc aatctcatgg 501781 gaaaaaacag tatccctgca aaaaatcgcg ctgcaagagc tgtctgcgcc gcttatcccg 501841 gtgtttgaaa atatcactgt gatgcctctt gtcggaacaa ttgataccga acgcgcgaaa 501901 cgaattatgg aaaaccttct taatggcgtc gtcaaacacc gttcccaagt cgtgctgatt 501961 gacattacag gtgtccctgt cgtcgatacg atggttgccc atcatattat tcaggcatca 502021 gaagctgtaa ggcttgtcgg agcaaaatgc ctgctggccg gaatccgtcc ggaaattgct 502081 caaacaatcg tcaacctggg gattgattta tcccaagtta taactaagaa taccctgcaa 502141 aaaggaattc aaacagcatt ggaaatgacg gatcgaaaaa tcgtttcatt gggggaataa 502201 cattttgaga catccgaaaa tcccgatctt gaaactgtat aattgcttat tagtgtccat 502261 tcagtgggaa cttgatgacc agacagcatt aacttttcaa gaagacttat taaataaaat 502321 atacgaaaca ggtgctaacg gagtcgtcat tgacctgaca tctgtggata tgattgattc 502381 atttatcgcg aaagtgctgg gggacgtcat tacaatgtct aagttaatgg gggctaaagt 502441 cgtcttgacc ggcattcagc ccgctgtggc agtgacgctg attgaacttg gaatcgcgct 502501 tgaggaaatc gaaactgcgc tcgacttaga gcaggggctt gagacattga agcgggaatt 502561 gggggaatag cgaatgaacg accaatcctg tgtaagaatc atgacagaat gggatattgt 502621 ggccgccaga cagctgggac gaaacgttgc gaaagaactg ggtttcggca cggtagacca 502681 ggctagaatt acaacggcta tttcagaatt agccaggaat atttatttat atgccggcaa 502741 agggcagatt ggaattgaac aggtcgcaga cagaggaaaa aaaggcctga aaatcatagc 502801 ggaagaccaa gggccgggaa ttcctgatat ccgaaaagtc atggaagacg ggttttcaac 502861 gtctggagga cttggtgcgg gacttcccgg ggtcaaaagg ctgatggatg aattcagctt 502921 aaattccgta gcgggggaag gaacagagat acaagccatc aaatggcttc ggtaggaggt 502981 aagaacgtgg attttaggga ggttattgag cagcggtatc atcagctgct tagtcgatat 503041 atagccgaat taacagaaac atctttatat caagcccaaa aattcagccg aaaaacaatc 503101 gagcaccaaa ttcctccgga agaaatcatc agcattcaca gaaaagtgct gaaggagctg 503161 tatccaagtc tcccggaaga tgtgtttcat tcgctggatt ttttaataga agtcatgatt 503221 ggctatggaa tggcttatca ggagcatcaa acccttagag ggatacagca ggaaatcaaa 503281 tcagaaattg aaatcgcggc aaatgtccag cagacgcttc tcggaactaa agttcctcag 503341 gaggaagcgc tggatatcgg cgccatcagt gttcccgcta aacagatgag cggtgattac 503401 taccactttg tcaaagacaa ggaatccatc aatatcgcaa tcgcggacgt gatcggaaaa 503461 ggcattccag cggctttatg catgtccatg attaaatacg caatggactc tttgccggaa 503521 acgggcatac acccttctca agtgctgaaa aatttgaatc gtgttgttga acaaaacgtt 503581 gatgccagta tgtttattac gatgttttat gcgaattaca atatggacaa gcatcaattt 503641 acatatgctt cagcgggaca tgaaccggga ttctattatt ctcaaaaaga caacacgttt 503701 tacgatttag aggccaaagg actcgttctc ggcatctcgc aggactatga ctacaaacaa 503761 ttcgatcagc atctggaaaa gggcgatatg attgttttat tttctgacgg cgtcacagaa 503821 tgcagaacgg aaaacggttt cttggagcgt cctgatctgc agaagctcat tgaggaacat 503881 atgtgttcct ctgcgcagga aatggtcaaa aacatttatg acagcctcct caaattgcag 503941 gattttcagc ttcacgatga ttttacgtta attgttttgc ggagaaaggt ttaacgtctg 504001 tcagacgagg gtataaagca actagtgatt tgaaggaaaa tttgaggtga tacgaatgaa 504061 tataaatgtt gatgtgaagc aaaacgagaa tgatatacaa gtaaacattg caggagaaat 504121 tgatgtatac tcagccccgg tgcttagaga gaagctcgtt cctctggcag aacaaggagc 504181 tgacttaaga atttgcctga aagatgtcag ctacatggac agtaccggat tgggcgtttt 504241 tgtagggacc tttaaaatgg tgaaaaaaca aggtggttcg ctgaaacttg aaaatctttc 504301 tgaacggctg atccgactgt ttgacattac aggcttgaag gacatcattg atatttctgc 504361 aaagtcagaa ggtggagtgc aatgaagaat aatgctgatt acatcgaaat gaaagtgccg 504421 gcccaacctg aatatgtggg aattataaga ctgacgctgt caggggtcgc aagcagaatg 504481 ggctatacgt acgatgaaat tgaagacttg aaaatcgcag tcagtgaggc gtgcacaaat 504541 gcggttcagc acgcttacaa agaagataaa aatggggaag tgtcaatacg attcggtgtg 504601 tttgaagacc gtttagaggt tattgtggcg gatgaaggag acagctttga ctttgatcaa 504661 aagcagcagg atctagggcc gtacacacct tcgcacacag ttgatcaatt atcagaagga 504721 gggctcggtc tatatttaat ggaaacgctc atggatgaag tcagagtgca aaaccactcc 504781 ggcgtcaccg tagcgatgac aaagtattta aatggggagc gagttgatca tgacacaacc 504841 atcaaaaact acgaaactaa ctaaagatga agtcgatcgg ctcataagcg attaccaaac 504901 aaagcaagat gaacaagcgc aggaaacgct tgtgcgggtg tatacaaatc tggttgacat 504961 gcttgcgaaa aaatactcaa aaggcaaaag cttccacgag gatctccgcc aggtcggcat 505021 gatcgggctg ctaggcgcga ttaagcgata cgatcctgtt gtcggcaaat cgtttgaagc 505081 ttttgcaatc ccgacaatca tcggtgaaat taaacgtttc ctcagagata aaacatggag 505141 cgttcatgtg ccgagacgaa ttaaagaact cggtccaaga atcaaaatgg cggttgatca 505201 gctgaccact gaaacacaaa gatcgccgaa agtcgaagag attgccgaat tcctcgatgt 505261 ttctgaagaa gaggttcttg aaacgatgga aatgggcaaa agctatcaag ccttatccgt 505321 tgaccacagc attgaagcgg attcggacgg aagcactgtc acgattcttg atatcgtcgg 505381 atcacaggag gacggatatg agcgggtcaa ccagcaattg atgctgcaaa gcgtgcttca 505441 tgtcctttca gaccgtgaga aacaaatcat agaccttacg tatattcaaa acaaaagcca 505501 aaaagaaact ggggacattc tcggtatatc tcaaatgcac gtctcgcgct tgcaacgcaa 505561 agctgtgaag aagctcagag aggccttgat tgaagatccc tcgatggagt taatgtaatg 505621 atccaggttg aagaaaacga gcatattcaa actctagtat atcaactgaa taaagaaggg 505681 aaatcgattt gcggtgacag tttttttatg aaagctgatg ataaggagtt aatttgcgcg 505741 gttgctgacg gactgggaag tggatcactt gctaacgaat cctctgcagc catcaaagac 505801 ttagtggaaa actatgcgag tgaagacgta gaaagcatta tcgaacgctg taatcaggcg 505861 atgaaaaaca aaagaggcgc tacagcatct atcctgaaaa tcaattttga gcaaaggcag 505921 tttacgtact gctctgtcgg aaatgtacgg tttattctgc attccccgtc tggtgaaagc 505981 ttttatcctc tgccgatttc gggctattta tcaggcaagc cgcaaaaata caaaacgcac 506041 accgccacct atgaaaaggg ttcaaagttc attatacata cagatggact caacgtacct 506101 gatatccgct cccatttgaa aaaaggccaa tcggtagaag aaatatcgaa ttcgctgaaa 506161 atgtatacga catcgagaaa agatgacctg acctatattc tcggacagct gtcctaaaaa 506221 accagaaaaa gaagctggac atccggcttc ttttttttgc ggttgactat taataagtgc 506281 gcttattata attaataagt gaacttatca ttctgggagc ttatgggatg tggaattatg 506341 aatacacagc gatagctgat gtggatgtgg gaaaacctgg aactgttatc aggaaacaga 506401 aacaatggat caatgggaga cgggtattgc atcagattct ttgaaaggac aatttcaaaa 506461 tggaacggaa ggaacattgc ttctgcaagg aaaaacaatt ctcttatggc ttgagcatgt 506521 ggagaaacat cgggcgtttt ctgtcatggt caacatgccc gcatagcaat gtaataatgg 506581 agttttttca cgtgcttcaa aagcaaaaag aagatttgtg tatcacatat ggaattgtat 506641 tagaaggcgc tgaagcaaaa aagtggggag aaatcattgg gactgaactg tctaaagaca 506701 tgccgacggc tgtcagcagg cttgtccatc tttacggagg agtgataaaa tgaacacaaa 506761 ttactggatc ggcgttgtgt cagagcaaca tgtattaaaa ggcgctgccg gcggttttgc 506821 acagctgtgc catggaaaaa aagccccgct cgccaaaatg aaagagggag attggctgat 506881 ttattattct ccgagagacg catatccaga cggcaaactg ctgcgaagct ttactgcgat 506941 cggcaaagta aaaagcggaa acatctatcc gtatcaaatg gctccgaatt ttattccata 507001 ccgattagat atagactatt atccatgcca taaaatcggt ttttacgaca ttaaatcaaa 507061 gcttgaattt gttcaggaaa ccaagcatct tggcttttta tttcgcagag gacactttga 507121 aataagcaaa aaagattttt tgacaatagc acaagcgatg ggagttaaca taagtggaat 507181 ggcactctaa atttagcggt ccgaacacaa gcccgggctt tttattatgg caggccacgc 507241 aaagttggca gcggaaagta ggaaaagcat tggctgagtt tgacctgacc cacgttcaat 507301 ttgttctgct gacctcgtgc aagtatatga ttgctcacgg agaaaccgtc acgcaaaaaa 507361 aacttgcaag cttcagccag accaatatca tgatggtttc ggaggttgtg cggacgcttg 507421 agaaaaaagg atttatcgaa agaagcaaaa atccccagga taaaagagag gtcctcctgt 507481 ctcttacaga aataggagga gaaaaagtaa cagcggcttt gccaattgtt gagaagattg 507541 atcaagcctt ctttgcagct gcgatgaaaa aagagaattt tctgagcggc ttacaggaac 507601 tattgaaaca tgagtaaaga tacgggcagc gccagctgtc tttttttatg tgtttttttc 507661 ggtttttgat acactagaga aagaacgaca aaattggagg ctttggttac atggaaacgt 507721 cagccctttt aaaacagcaa attgcgaaag aaataggttt atcacaaaaa cacgttgaaa 507781 gtgtcatccg cctgcttgag gacggcaata cagtcccgtt tattgcccgg tatcgaaaag 507841 agcagacggg ttcaatggat gaggttcaga ttcagacgat ttctgaacgc tggcaataca 507901 tacaaaacct gaatcagcga aaagaagaag tcatcaggct gattgcagag caggataaac 507961 tgacagataa tctaaaacgt aaaatcgagc aatcggtgaa gcttcaggaa gtggaagacc 508021 tttaccgccc ttataaacaa aaacgtaaaa caaaggcgac agtcgccaaa agcaaaggcc 508081 ttgagccgct tgccgactat atcctgacac ttccccaaga tgatcatctg gcagcaactg 508141 cagaccaata catcagcgaa gaaaaagaag tgttcacacg agaagaagcg attgaaggcg 508201 ccaagcacat tattgcggaa caaatctcag acgagccgac cttcagaaag tggattcgcc 508261 aggaaacctt caaaagagga accattaagt ctgcagccgg aaagtcggca gacaccgatg 508321 agaaaaatgt gtatgaaatg tattacgagt atgaagagcc aattgcaaaa gttgttccgc 508381 atagggtgct ggcaatgaac cgcggcgaaa aagaagacat tttaaaggta gcgatcgaac 508441 cgcctgcgga tcacattaag gcgtatttag aaaaacaaat catcaaaaat cgctcaacat 508501 ccgtaagaga gattttgcag gagacaattg aagacagcta taaaaggctg atccagccgg 508561 caatcgagcg tgaaatcagg aaagagctct cagaaaaagc tgatgaacag gcgattcata 508621 ttttctcaga gaacttgaga aagcttcttt tgcagccgcc gatgaaaggc aaaaccgttc 508681 tcggtgttga cccagccttt cgaactggct gtaagctcgc tgtgtcagat gagaccggaa 508741 aagtcttgaa aattgatgtg atctatccgc atgcgccagt caacaaaaca aaagaagccc 508801 atgaaaaagt gaaaaagatt cttgagcagt atcaagtcga gatggtggcg atcggaaacg 508861 gcacagcatc cagagaaaca gagcaattca tcgtcaatgt actcagagac atgccgcgca 508921 aaatttatta tgtgatcgtc aatgaagcgg gagcaagcgt ctattcggct tcagagcttg 508981 ccagagaaga attccctgac cttaaggttg aagagcgcag tgccgtatct attgctcgga 509041 gacttcaaga cccgctcgcg gagctcgtta agatcgatcc gaagtctgtt ggtgtcggac 509101 agtatcagca tgacgtcagc caaaaacgct taaatgaatc tctgcggttt gtcgtcgaaa 509161 ctgtcgtaaa ccaggttgga gtaaacgtca acacagcctc cgccgcgctg cttcaatatg 509221 tagctggatt atcgaagtct gtagcaggca acgttgtcaa aaaacgtgag gaaatcggaa 509281 agttttcaaa tcgaaaagaa ctgaaggaca tcccaaggtt aggtgcgaaa acctatgagc 509341 aatgtatcgg tttcttaaga gtgcaggaag ggacagagcc tttggataga acaggcatcc 509401 acccggaaag ctataaagaa acaaaagcac ttttgaaaaa actcggactt tcaacagaac 509461 atatcggcac ggcggaattg aaggacaaaa tcaatcagct ggcgctctct gaaacggcaa 509521 aagagctggg aatcggcgaa atcactctga aagacatttg tgaacagctg acaaggccgg 509581 aacgcgatcc acgcgataag gtgcctaagc ctttgctgaa aacagacgtc cttcagctgg 509641 aagatttgaa agagggaatg gaactgcagg gcaccgtgcg caatgtagtg gacttcggag 509701 cgtttgttga tatcggagtc aaacaagacg ggcttgtgca tatctcaaaa ttgagcaatc 509761 aattcgtcaa gcatcctctt gatgtcgtat ctgtcggcga tattgtgaca gtttgggttg 509821 acggcgtaga tgtacaaaaa ggcagagtat cgctgtctat ggtaaaataa aagcactgct 509881 tacgagcagt gttttttcct atagaaatac cagcattgat tcagcagttt aatttggtaa 509941 ttatcttttt caaggaacgc tttttgcatc tgctttttaa gccaatttgg cataggctca 510001 ttcctcctca gcttttatca taagagggac agtgattacc atattgtatg cgaacggtga 510061 attgtcccgt tcaatgtttt ttaagtgagg tgcaccatgg ataacaaaga gcttcaaaag 510121 ctgacagagg atatttctga aacatatttt aaaaagccgt tccgccatca ggcgcttttt 510181 aatgaccggc ttaaaaccac tggcggcagg tacctgttaa cctcccataa cattgaattg 510241 aacagaaaat atttgattga acacggcagg gaggaactga ttggcatcat caagcacgag 510301 ctctgccatt atcatcttca tcttgaagga aaagggtaca agcacagaga cagagatttt 510361 agaatgctat tgcagcaggt caacgcgccg aggttctgta caccccttaa gaaaaaagcg 510421 gaaaacaaaa aaacttatat gtatatctgt acgacctgcg gccaacagta tataaagaag 510481 cgcgccatga accctgacag atacagatgc ggaaaatgcc gcggaaaaat aaaaagaatt 510541 ttttcgtgaa aaaggttgac gaatatggca agcctatgtt acattataaa agtcgtcacg 510601 agagataaat aaaaacattt acctcttgac actgcaaatc aaggctgata taataagtct 510661 tgtctcatta ttccacagta gctcagtggt agagctatcg gctgttaacc gatcggtcgc 510721 aggttcgaat cctgcctgtg gagccatatt ggagaagtac tcaagtggct gaagaggcgc 510781 ccctgctaag ggtgtaggtc gcgtaagcgg cgcgagggtt caaatccctc cttctccgcc 510841 ataagatttc gatataagtt ctcaaccatc ggcccgttgg tcaagcggtt aagacaccgc 510901 cctttcacgg cggtaacacg ggttcgaatc ccgtacgggt cattccattt cgttgggcta 510961 tagccaagcg gtaaggcaac ggactttgac tccgtcatgc gttggttcga atccagctag 511021 cccagccatt tttatttttg aaatctaata gtaagagcca ttagctcagt tggtagagca 511081 tctgactttt aatcagaggg tcgaaggttc gagtccttca tggctcacca tttgtctttt 511141 tgcgggtgtg gcggaattgg cagacgcgct agacttagga tctagtgtct tacgacgtgg 511201 gggttcgagt cccttcaccc gcactttatt tacaaagtgc acgcaaatct gttttactag 511261 gttaagagcc tactaaacca gcacaacaca atttaatgat cacgcggtcg tggcggaatg 511321 gcagacgcgc taggttgagg gcctagtggg tgaataaccc gtggaggttc aagtcctctc 511381 ggccgcatca atgataccaa gggttttgac acccttggta tttttttgtg tttattttca 511441 aatgatttac tgcccacaaa ctgcccactt acctaaagta agtcatctaa tttatcagcc 511501 atttcctttt gcttgtttgg atataggtgt ccataaacat caattgttgt ttttacagaa 511561 ccatgtccta aacgctcttt aattgttatg taatcttctc cttggtgtat taatagtgca 511621 acgtgtgaat gtctaaaatc atgtaaacgt ataggagtaa gatcgctatc cttgcaaaag 511681 tatttaattt tccgactgaa aatatctttt cttgaaggtg tatctttata ttgaaagata 511741 taggtatcat gtgaatgtct aatacctaat tcattaaaca actcttcttg tgcttctttc 511801 caacgttcta gtagcttaag caatttttta ttgatgctaa ctcgccgaat cgaattttta 511861 gtttttggag tagtaacaac aaattgacca tcaagccagg tgcacgattt atgcacatct 511921 atttctaata agattttgtc aatatctttc cattgcaggg cgagcatttc accacatctt 511981 agtccagtta aaaaagcaac agtgtaaaag gttttaaaca ataattgatc ttgaggaatt 512041 aaactaataa attttttgaa ttcttctggt ctccaaaact tcattttctt tcttgttaaa 512101 ggtaatcgtt taacgttgtc acacggattt ctttttaaga tttcttcatg tacagctgta 512161 tcaaaaattt tgcttagact agtcattata ttattaaccg atttattgct tagacctgtt 512221 tccattaaat gttttctgaa atcagttatt tctctatgtg tgattttttg tatatcagat 512281 ttcaaaaagt aatcagatat atgtttgttt ataatgtact tctgattctg ataatagttt 512341 ggtttactat ctatttcaca acttgctaaa taaattgaaa ttagagtcgg aaagcttact 512401 gatctggact ttcttgctct ttcttcttga aattctcttc ttaattttgc ttctaattct 512461 aaagcctctt ttctggttga tgctactggt ctcgtcctaa ttctttctcc agtaatcggg 512521 tcaaatccaa agctaacgtc aacttgatat tgaccatttt caagtttttt tacagacatt 512581 ttatttctcc tttaaccaaa agcgcttatt tcgtgtgaat agattctgtt actaaatgag 512641 ccaatttgag aaagtttata atcagtaaca aatgatggta cgttgaagta tgctgctatt 512701 tgttctttgc taaaaccctg tatatatgga agggcttcat taagcatttt atctgtcagt 512761 attaattctg atgcaaatag gcttgcttga tgctcaagtt tatcttttag aactttagag 512821 caattcacaa ctttaaaagt gttcaatctt ttatggagaa agtaatgccc taattcatgg 512881 gcaattacaa attgttgatg ttggaggttc tcgttgatat ggattaaata ttgatctgtg 512941 gctttgtcat gttgtagtaa accgtttgct tgtccaagat catttttgag tatataaatt 513001 ttttggatgt cacaaatttc atagacatta tttgtaccat gtgtcttaat tactgattgc 513061 actttatgtt taattccttt gcttgtataa attgttatca ctctttcttc tttaattcgt 513121 caatgaattt aattccgttt tttaatgctt ttttaacaag gcgtgcagtt tcctcatcaa 513181 attcaccatc attcataaaa aggagtgtat cttcatcctt taattcctgt atggcttcat 513241 taattgtttt attgagtaaa tcagtttcgt ttttcttgct tacttcatcc tttcctaata 513301 aatagtctgt agatacgtta tataagttgc tcaattttaa gagtgtgtct gtatcaggat 513361 ctctgtaatc tctttcgtaa ttagacaagt tattgttacc gatattaagt ttctctgcgg 513421 cttctttctg agtgtaccca gctttttgtc gagcttcttt taatcgtttg cctaggctca 513481 tttttatcat ccatttcaca aagagttgat ttttataaaa ataataacaa cattttttgg 513541 agaattcatt aatttcacct ataagttaaa taaataattc taaattctcc ttttaggagt 513601 gtttgtttct tctttatgga gagtttaatt atcaatattt ccatatatgt tcaaaaaaat 513661 acactttaag gtgaattttg tgttgactta cacgaaaagg agttttataa taaagttaat 513721 tcacaaagag ttgagttaac gaggaggtga tattttgaaa ggagagtttt taactgcgag 513781 agatattcaa aaaattcttg gagttaaaca ggctaaatct tatgacatca ttagaacttt 513841 gaatgctcaa atgaaagaag aaggatatat ggtcattcaa ggtaaggtga gtagagctaa 513901 gtttgaagag tgttattgtt acaaaggccc aaaatctcaa acggggtgat ttttataaac 513961 attgatataa caaactcgtt tatgaaagaa gctgtccctt tagctagaca aatggaaggt 514021 gattggatag cacgaatgaa aattgctctg aattcagtca ttataaatca ttatttaaac 514081 cttcccttaa caattgaaaa tgttaatgaa ttactgcgaa aaggcgtttc atatcgcagg 514141 atatgtaagc attacggcat tggaagaaaa gacattgaaa agcttcggca atcatccgta 514201 gtgtgacgtt atataccact atagggagcc gttaagaatc ctttgaaagg agggatgcga 514261 tgaaaataag agtgaatgca acaatcatta ctgatgttga agctttaaag gctgataagg 514321 atttgaatca ttttaaagac tatgccactt gtgaaacatt cgttgttgat gctgataatc 514381 atttgaaggc taatgaagaa atatctgagt tgttaaaagg ctgggattgg tggtgtatct 514441 ggtcaactcg tccattgagt aaaaaggata accaagtgtt tactttgtat aacgatgatt 514501 tgtataactt atgtcgatag gagtgtttgt tccttgaaaa ctacatatag acaaaaaaag 514561 cgccttgacg aatgatcatc aagaacgccg gaaaataaaa actagacact tttattatac 514621 ggtattcttg ttgaaatgtc atgcgtgagt atttgagtga tgaacagcaa tcactttaaa 514681 tgctgtagca ggctagaata agcgtgcgga atagctgtag tcagcttgat ggctataatt 514741 agcctactag gttgccatga gggcgtaaag ccgttagcaa ctgataagcg ccaagatgga 514801 tacagaaccg gagcgaatca aaaacataaa atcgaaatta atgttctttt gtaaataaat 514861 tataaaaaaa tgaaatgggg atatgaaaaa tgaacttaaa ctttattgta ccggatatca 514921 atatgacttt tggagacatg aaattcatgg gacttaacag agaaaggtat gtttatgatc 514981 gtgaaaataa taagcgtact gacgtactgg aatctaggat ttataacatt gctagtgctg 515041 tccaaggtgg tcaaattgaa gtaactattc ctgagtatgc tggggcaaaa gaaattcctc 515101 cttttgcaga tattgagttg aaaaatccaa aaattagcgc tatggcgact agtcaaaggg 515161 attcgacgta tgccaatgtg atgtggaaac ttgaagctga tgatattgtt gttaaaggtg 515221 gctcttctgt gaaacctgcc gcggcaactg gcgggaatga aaagaaataa catgatgctc 515281 tcatatcggc aggcgggtga tgtatatgag tgatttctta aacaaaagat tttggaaata 515341 caggggcaaa cgaatccgcc cgtacatgag aaacaacgta aagttagcag gcgcaatcat 515401 ctttgtgcct gtttttttat tgtctatgtt ccttttttgg agagaacaac tcattcattt 515461 tgatctatct caagtgataa aaaattttga atggaatgtg cctttaatca ttaaaagcgt 515521 tttatgctct gtgctaattg ctgttggaag catagttgca tcttactttc ttttgtttga 515581 cagctataag aaaatccttc acaggcaaaa gattgctaaa atgattttct ctaacaagtt 515641 ttacgaaaaa gaaaacgtga aagtaagaaa aatcttttca aatgaaactg actcaaagga 515701 aaagatcaca tactttccta gaatgtatta ccaggtcaaa aacaaccaca tctatattcg 515761 tattgctatg gacatgagcc gttttcagaa tcgcttccta gacttaggaa aggatttgga 515821 aaacggctta ttttgtgact tggttgataa acaaatggaa gaaggttttg tatgctttaa 515881 gcttctttac gatgtcaaaa agaatcgtat ttccattgat gatgcagtag ctgagaatgg 515941 agtccttccg ttaatgaagc atatctcatg gcaatttgat aagttgccgc acatgcttat 516001 tgctggtggt acaggtggag ggaaaacata cttcatgcta acgatcatta aggcatgtgt 516061 tggactgggg gcagatgtaa gaatactaga ccctaaaaat gcagatttag cagacttgga 516121 agaagtactt ccgaaaaagg tctattccca aaagaacggt attcttatgt gcctgagaaa 516181 gtctgtagat ggcatgatgg aacgaatgga tgaaatgaag caaatgtcta actataagac 516241 aggtgaaaac tatgcttatt taggcttaaa acctgttttt atcttctttg atgaatatgt 516301 ggcatttatg gatttgttag atatgaaaga aagaaacgaa gccctttctt acatgaaaca 516361 gttggtcatg ttggggagac aggcggggta ttttctcgtt ttaggcgcac aacgtccaga 516421 tgcaaaatat ttagctgacg gtattcgtga tcagtttagc tttcgtgttt cattgggttt 516481 aatgtccgat acgggttacg gaatgatgtt tggcgatgtt gaaaaagcat atgtgaataa 516541 aaaggagaca gggcgaggat atgccaatgt gggcacaggt tcagtgttgg agttttacag 516601 ccctatcgtg ccgaaaggat atgattttat gtcatctatt aaaaatgcgc tggttggagt 516661 cgagggagcg caggcgacgg cagtcgccag cggcagcgta agcgaccaga cggccagcgg 516721 cgaaggagtg agcgaagcga atggatgagc taaaacaacc cccccacgct aacagggggg 516781 tagtaatcgt aaaagaaaaa aatgaagccg ttgaaagtcc tttggtatca atggttgact 516841 atattcgagt ctcttttaaa actcatgatg ttgacagaat tattgaagag gttcttcacc 516901 ttagcaaaga ctttatgact gagaaacaat ctggtttcta tggctacgtt ggcacgtatg 516961 aactggacta tatcaaagtc ttttattctg cgccggatga caacagaggt gttttgatag 517021 aaatgtccgg tcaaggttgc cgtcaatttg aatccttctt ggaatgccgg aagaaaacat 517081 ggtacgactt ctttcaagat tgcatgcaac aaggcggttc gttcactcgc tttgatttag 517141 ctattgatga taaaaagaca tacttttcta taccagaact gttaaagaaa gcccaaaagg 517201 gcgaatgtat ttcacgattt agaaaatctg atttcaatgg ctcctttgat ctatctgatg 517261 gcattacagg cgggacgaca atatatttcg gttctaaaaa gtcagaagcg tacctttgct 517321 tttatgagaa aaactatgaa caagcagaaa agtataacat tccgttagaa gaactaggcg 517381 attggaatcg ttatgaattg cggcttaaaa atgaacgtgc acaagtggcg atagatgctt 517441 tattgaaaac aaaggattta accttaatcg ctatgcagat cattaataac tatgtaaggt 517501 tcgttgatgc tgatgaaaac atcactagag agcattggaa aacgagcctt ttttggtctg 517561 attttatagg cgatgttggg agacttcctt tgtacgtcaa accacaaaaa gacttctatc 517621 agaaatcaag aaactggctt cgtaactctt gtgctcccac tatgaaaatg gtgcttgaag 517681 ctgatgaaca tttagggaaa accgatctgt cagatatgat tgcagaagct gaactggctg 517741 acaaacataa aaaaatgtta gatgtgtata tggctgatgt tgctgacatg gtcgtttaaa 517801 accaagctgc taaaccttaa taaacacagg tgatgcgatt aaacgtatgt gtcaacggta 517861 ccggaacgaa gtgaggataa ggagttgaca tattcagcgc tacccaaacc ctcttggcat 517921 tgaacaaaca accgtttgtt cctgcctacc ggcgagggag tcccccgatg attcggggga 517981 atagggggat agattaacag caatccaacg agctaccgtt ggtgggtttg ggtgaaaccc 518041 aagaactaac ttggagggat aagatgcata atgtcaatct gttgaatcag gctggactgg 518101 aaaatgcttt ggaatcagtt ggctgtttag atattgtaga agatttaata gaaaagatgc 518161 aggaatatgt tttgtatcat accgaaactg ccgaaagatt tgcgattgat atctttacag 518221 tagtaaacaa ctacactaaa aaggttcatg cgatatttaa tgttcttgaa aatgaagacg 518281 gtgagacaaa tgttaaaaat gtagaatttg aagtaatgca ttttacggag taaggacaat 518341 tttccttatg actttaaagg gggaacatca ggtgtttaat attaatctgt tgaatcaggc 518401 ccgacttgag agtgatttgg attcccttgg gtgtttggat attgctgagg aactgattga 518461 aaaaatgatg gaagatgttt tttacagtga tgtagctcaa agaatcattg ttcaaacact 518521 tgctgttata aataacgcca atgcaaaact tcaagctacg tttaacatct tagaagatga 518581 agatatggag acagacgaac gaagcgtgga gtttgaagga attagctact acgaataagg 518641 ggtgaaaatg tgcggtgtct gctgtagata aacgattcaa aagcttaggt tttaatgtgg 518701 gcattccctc tttagttttt gtgagaagtt taagcagaga ttgcatgttg gttgttgaag 518761 gagaacgagt aaaaggattt gctgagtatc gttacacatt ctataaaaca agatacttgc 518821 cagacggtcg aatgactagc ttaaaagttt atatggagaa tcaaagcata aaaagggtgt 518881 tacatcgtgt agcatccttt ttatctttct tggaaagaac gaaacaaatt gaacagaagg 518941 agtgtgaaaa agttgctcaa taaagaaatt ggctctgata agaaggaaga atcctttttt 519001 cggtctgctt ttcaaaaact gaaacgaatt gaaagaccgg aaaaagacaa acaaaaagta 519061 ccccgtgaca ggtcaaagct gatagccgtc acactatggt cttgtgtagg gagcttgcta 519121 tttatctgtc tgcttgctgt gcttctgtca attaatactc gctcccaact taatgacatg 519181 aaagacgaaa cgaataagcc aacaaatgac gataaacaaa aaatttcggt gactgctgcc 519241 gaaaactttc tgtcagggtt catcaatgaa tatatgaatg tgaagaacga tcaagaatct 519301 attgaaaaac gtatgcagag ccttgaaagc tatatggtta aacaggaaga taaccatttt 519361 gaagatgaag aacgcttcaa tgtggatggt ttaaaaggtg atcgagagtt aaagggttac 519421 agcttatata acgtgaaaga aggtgataaa aacagccttt ttcaatataa ggtcacatat 519481 gaaaatctat accctgtaga aaaggaagtt gaaaaagaag ttaaagacgg aaagaagaaa 519541 aagaaggtga aagaaaaggt taaaacaaac gagaaatacg aaaaacaaat gttgctgaat 519601 attccagtca caaataaagg tgattccttt gcggtgtctg ctgtccctta ttttacacag 519661 atttatgatc tgaaaggcga tattgctttt aagggtaaag aagaaactag agacgaatat 519721 gcaggcgaga aaaaagaatc tatcgaatca tttcttcaaa atttctttga gaaatacgct 519781 tctgaaaaga aagaagaaat ggtttatatg atgaaaaagc cggaagcatt ggaaggaaac 519841 ttgttatttg gggaagtgca gtcagtgaaa atcttcgaga cgaaaaaagg tttcgaggtt 519901 ttttgtgctg ttcgatttaa ggaaaaagaa aatgacattc cggtaaatga aaaattcagt 519961 ctagagatta cggaaaacag cggtcagttt tatgtaaata aactcaaaca tcaataggag 520021 gtttaaatat ggatttcatg aatttcttta ttcttggcgc agaccttcca acacttggag 520081 gggtaaaagg ttgggcatca gatgttgtta tccaattcat tacgattgtg gtcatgttca 520141 tagccgcaaa gaatctgatg aaattaaaaa tgggcggcat tatctttgtt tgctgtattg 520201 gcagtgcggt aacgtgggtt attaaacact ggtcagaatt ctccggctgg atcaatgcgc 520261 taatggaaaa attgtaaggg ggcatctgaa tggggcgtct ggtgttcaac taccggaagg 520321 caatgagaga gccgaaaaaa atccaacaat taaccgaaaa ttattcgtta ccctttgcag 520381 ttgagttaat accggctatt aactatttca tttttgttgg cttatgcttt ggattctggt 520441 acggcgtgag gatgattttc cctcacgctt ttgataacag ttacgtcatt gtgatttttg 520501 ggataccatt ttttttaacg atgcttgtaa cgaaaataaa gccggaaggc aaaaacatct 520561 atatatattt ctttgatttc gcaaagtatt acttcttcat caagcttcca caaaagaagt 520621 attgcaatga tcgaaagatt gatttaagta acgaaaaaca aattgagttt cgaaaacttg 520681 tgaaggtggt ggattattca aatgagacta aaaacgccta tgaaggcaat acacaagaat 520741 ttgctgttaa caagaacggg cgacgtgtgg gcgtactacc gaataaaaag caattcgatt 520801 cctatgcaaa ataaagaaaa agttgaatcg tataaaaaga agtggcagca tctttttgaa 520861 gaaattacat cttatgagga ttttcacttg atgatgtatc caagtgagta tgaattagaa 520921 aaacgattta aggatttaga aacagatatt gcggcagatg caatggatgt ggcacgttac 520981 tacaatgaag aaaccgtaag gctgttagaa cagcgattag gaaggctgac aaagtacgac 521041 ttcattttag gtgtaaaact gaaaagcagt cttgtaaata ttagtgtcga acttaaagac 521101 aatatactat cttttttcaa tacagcgact gatacagtcg tgaaaatgct cgggtgggaa 521161 caaaatgttt ccacctcttt ttttgaaaaa tatgaggaag tcgaagaaac actagcgaat 521221 atcatggctt ctgttcgcgg agaacggctt tcagaaacag aaatgacata cattaaccgt 521281 tatcactttg tacgtgggtt aaagcaccaa acgaatgaag aaagtgagat aaaggatgtt 521341 cgctctatta caaacacgat catagacccc actgacccat cagtattgca tttgcatagt 521401 gatcaagatg aaggctattc agcttttgtc gtgattgacg aatttcttca caatatgtcg 521461 gaaagtgatt tgttttatga agcacagtct cttcccttcc ctgttgaagt tcagatgaaa 521521 attcaaacgg aatcaaagtc cattaccaag cctgccctca acctcaaaag acagcaattg 521581 aaagaagaac aaaaagaaca acaaagcaca ggcgatcgaa gtgatgtttc cactgtcaca 521641 agtgccacaa tgataaggca tttacaagat gaaataaaga aagaagatgt gcatgtgatg 521701 aactggctgt cggtgatagt cgttcatgga aagacaaaaa aagaatgtgt gggaaaagca 521761 acgattgtca aaaggcattt aaaaggcgct ggcattactt gtcggcttcc ggtggctgat 521821 caattgaacc ttttttataa aatgcttcct ggtgaaaagt tagacataac cgataagaac 521881 tggattcaaa aaacaacgca agacggtgtg gctgaaagtc tgtttgctgt taactctgat 521941 attggttcga aaatcgggtt ctttctcggt tgggttgatc gtttccaaga gcacaccgac 522001 ttagaaagtg ccattatgtc cagccgtgat tttgtcttat tccacccttt cttagcgaat 522061 cagcagttaa aaggttcaaa gacacgttct cctcactgct taatcacagg agacacagga 522121 aacggcaagt catatctagc gaaattgatc tttaactata tcagcatgtt aaacatcaaa 522181 tctctgtata tagaccctaa aaaggaaatg agaaagtgga ttcaaagagt cttgaatgat 522241 gagtacatta gagagaactt tcccttatat attgcacatt tagagaaata caactatatc 522301 acgctagatc atgaaaacac gcacaactgg ggagcgcttg accctatctc cttcctccct 522361 cctatgaaag caaaagagct agttcaagtc atttttgaac aagtatatga ctttaaaggg 522421 aaggacgaca taaacacagc tttccttcgt gctacgtcag aagtgattga tgcgaaacaa 522481 aaaggtgaac aggtcggctc acttgatatt attcggaaga tgcagagcca tcccgaagaa 522541 gctgtacaaa aagctggtga ctatttaaat gaggtcgtgt cagattccat tttgaaactt 522601 tgtattcatg atggttcaaa tcctgcattg tcactagaaa agcgaattac cattttagaa 522661 gttgaaaata tggatttgcc ggatcatgct gagcgacttg aaaactacac gatatcacaa 522721 ctaaagtcta gtgcggtcat gtttgcacta ggtaagttct gcgagctatt cggcatgaat 522781 caagacgaac agactgttga atttatagat gaagcttgga tattcaccac gtcacaacaa 522841 ggaaaaaaag tagaaagaca aatgcgccgg attggtcgct catacaacaa tgcggaatac 522901 ttcatttctc aatccacaaa agacgcttta aaagaagagg attctggaaa ctttggcgtt 522961 gcctttgctt ttgacgaacc aaacgagcgt gaagaagtgt tgaaatggat gaacatggag 523021 gtcacaaaag ataacaaaaa aatgatggaa tccatgtttc aaggtcaatg cttatttaaa 523081 gattactatg gccgcacctc taaaatttcg attgaatgcc tattcgaaga atggcaaggt 523141 gctctgaaaa cagttgagaa aaaagccgtc gcatatgcgg aagaaaaata tttgtaaaaa 523201 ggggttgaat cgtacatgga aatagctttc ttaaactctc ttgttgtcac gagtccaggc 523261 ttttataaag ctgagaaaat cacattggac gaagttaaac aatggctgaa gcattatgat 523321 ggtcgataca aaagttttat cggacataaa tcaacggcac agtttctgca aaaattatta 523381 ggtatcagaa ttgagcaaaa tcgaaagact ttcagacata tgaaatatca aaaagcaatc 523441 tgtttctctc tgtatgaacg atatcctgaa aacgtgttgc taacgcaaag agacttagag 523501 aaagccagat accaatttta tttattaact cggttagatt aggaggtggt tgtaatgaaa 523561 aagaaaagaa ttttgattgt gtcggctatt gtgttgctgt ttttaactgt tgcttcagct 523621 gtaacggtat tttcggctga tggagataca acgacgcagc caaaagtcga aaaagctggc 523681 ggcgtggaat tgaaggtgaa aaggtttcca atctcacgct atcaagcgaa taatgaagca 523741 tctgacgatt taatcaaggg ggcgtttgtt gggctgacaa acgtcacttt ttcttttgcg 523801 ggaaacattg tccgtgtggt tgatacgggg atggatattt tgtataactt gcaaccgatt 523861 gacgagttcg caaattctat tacaaacgtc tctaaaacag tttataaaac actgaaaaag 523921 aatttcggtg aagctttatt tattttcacg tgcgcctatg ttgtctacct attctgtgtg 523981 agaggtagcg taaaagaagc aatgcggcgg agtattctat ttatttgtgt catggtgatc 524041 ggtgggcttt ggatgtcgaa cgctggttat tacatgaaag tattgaatgc cttgtctgta 524101 gaagctcaag gaaagctttt aactgcgggg aatggattgg ttggcattgt tcaagatgaa 524161 ggcaattttg cagacagttc agcgattgaa aaaggaaaag aaatggaagg cacagttgcg 524221 gttatgcgta atctttactt tgacattgct ttgatgaagc cttttttaat tgtgaatttt 524281 gatgaaacaa gcgaaaagaa aatcaatgag gaagatacag ataaaggcgg acttaatcgt 524341 atagataaac tgctttctta taagctttca gaggatggag aaaaagataa aaaagattat 524401 ataaaagaga ctgaaattga tgattataaa aatgaatcta tgacttctgg aaatgtgttt 524461 aatcagctgg gagagtcttt tatcgctgtg gtcgcttcta ttgtcattgg gataccattt 524521 ttagcattag cgttctttaa tttcttgctt caagttgtcg ctttagtgat agttttcttt 524581 gtgccatttg ctttcatctt agcgtatgtt cctcaattag cttattcggg atttgttacg 524641 cttggacgct tggggagtgt ttacctactg aaagcaatgt taggggttat cgttctgttt 524701 gtgtacgtga cttgttttat tgttgacaag ttaataccgc caaatggttt tggaatgtat 524761 cttttaaatg ttgctgtcct tgcttcaatc ttgtggattg gttttcacaa gagggatgcc 524821 attatcaagt ttgtgactgc tggaaaagtt gtttcagttg ataataatat gatggaaaac 524881 atgagacaaa acattgttca gcctgcttgg gaacaagcga agaaaatagg tggagtatgg 524941 ggtaacggag gcggcgtatt tactgacttt acaaagcatt ttgggggaag aaaagacggt 525001 tcgaatgctg atggcgtaac tggtgctcca agtggtggcg gtaattcacc gagtgggact 525061 gctatgggat atgataatac tcatgctatt tcaagaaccc cgcaaaaaga aacagctaac 525121 ggaatagcta atcataacag tcgaagctta aaacgcaatc ctcaaactct atcgaaagaa 525181 caagaaaagc aaaaacaaaa agaagccttt gcaaatgcaa aagaaaataa acagcaatcc 525241 catttagcca gattgagaaa agacggaata aactctccta tgttgaaaga tgctttgaat 525301 gaagggaatg aggatttatc caaacgagca cctatcttgc aggataaaaa agatgaatca 525361 gcacgaacag atcaaaaaga atatgtggaa cagcttctta aacagcccaa taaccagcaa 525421 caaactgacg atgcatcatt acagcatgaa gaagaatcta cttctaatcg tgcgcctgtc 525481 ttacaagaga atgaaaaaga tacagaacgt actgatcaga aagcgtatat ttatgacgaa 525541 caaaatcaga atcttgaaac agatcagcaa caagattttg aagtccagaa agatgattct 525601 gtttccaata gtgagcctgt agcacaagag aaaacagcag aaatcaaacg atcagatcaa 525661 aaagtcatga tgaatcaacc tgaaccgcag ctcggttttg aaagtcctca atctacaaaa 525721 gtagaaaatc aacctattgc caataacgaa cgtaaaatca gaccatctga acccgcaaaa 525781 gttcattcag atggtattcg tgttgatgaa aaacaggctg ttgctcctgc tgaaaataag 525841 actgtatcaa gagaaaaaca gccttcatca caaacaatta aacggactga acaaagcgtt 525901 aattcatttg accaagtgtc tttgaatgaa attgcaagac gctcttcatc aaaagtagaa 525961 gatcgactga gaagggatga aagaacaaga tgataagtaa aaaggtagtt cttcctttgg 526021 tattctcggc tccttttatc ttcttttttg ttttatgtat cgtagtggtt atgacgattt 526081 caagagaaaa tcaagtcggg gacgatttta taggcggcgg ggatggcgaa tatgaaacag 526141 ttggaattgc gccggaagtg gaacgattta gagcagtatt tgagaaatat gcccgtcaag 526201 aaggcgtttt tgaccaagtg aatattatta tggcgctcac catgcaagaa agtggtgggc 526261 gttctttaga tatcatgcaa agttccgaaa gtatcggctt acctcccaac tccataactg 526321 acccagaacg ttcaattgaa gtcggcatta aacattttaa gaaggttttt aaacaggctg 526381 gcggtgatgt tcgtttaacc ttacaggcat acaactttgg ttctggattt atagactatg 526441 tcaaaaagaa tggcgggaaa tacacaaaga aattagcact tgatttcagc cgattgcaag 526501 cttttaaaat gggctggaaa agctacggtg acccaagtta tgttgaccat gtcatgaggt 526561 atgtgaaagg ctctgataaa aatgtgaagc ctgtgaaagg ctctatggat ttctatgaaa 526621 cggtcatgaa agaagctttg aaatatgaag ggcaaccgta tgcctgggga ggttcaaacc 526681 cggaaactgg atttgattgt tctggccttg ttcagtggtc ttttgcgaaa gctggaatca 526741 ctcttcctag aacagcacaa gaacaacatg gggcaaccaa gaaaataagt gaaaaagaag 526801 cgactgcggg tgacttagtg ttctttggcg gcacatacga aggaaaagcc attactcacg 526861 tcggcatcta tgtaggcaat ggcagaatgt ttaattcaaa tgacagtgga atccaatatt 526921 ctgatctgaa atcaggttac tggagagatc accttgtatc ttttggacgc attaaataac 526981 taggagtgaa aatatgaaaa cacatattgc atgggcttca gcttgtttat tattagtcat 527041 gttaactgga tttttcacga ttggacagca aacgtataag attgaaaagt taaaagataa 527101 aaatgaagtt ttgagcgaaa aaattaagga attgaaccat atagaatcaa caagtagcgc 527161 ttcggaaaat aaggcatttt ttgaagcgtt ttttaattac tccgacatag atatacgata 527221 tgaaacagtt aagaagcaca caactggaaa agggtttgat tatgcattcc cttctcgttc 527281 tgatcaaaag cacacagtca gcgtgcaaag tgaattacta tcactagaga gttattcaaa 527341 gccgttagat gagtctcatg aattgttttt aaacattgtt gaagtcgcca caactgcaaa 527401 ttcagtcact acgaatcaag tgttaattgt acaaacgact atgaaaaaag aaaaggatgg 527461 ttggttagtc gataatgtgc aggttaaggg aaatggataa aaggtggaaa agatcaattt 527521 gtttgtttat actaaatatt gaaaaaggag gtaatgttta ttttgaaaaa cctttttatt 527581 ttccttagtt tgatgatgat gtttgtttta actgcatgtg gtggaagcaa gtatgatgat 527641 gcgattgatg atgtaattag ccaatataaa gagcataaag gaaatgacac agagataaat 527701 attaaaagag agaatgcgat tgttagagtc tatgaagggg gcaaatatat tcagtttgca 527761 ttttatatgc cggataactc ttcacgtgaa ttaacaacat ttaagtatta tgaaaaattt 527821 ggagataaat atgaaaagat gactgatatg ccggggaatg gggaaaatga tcgtctgggg 527881 ttatcaaaga aaacaccaga ctatgaagaa gtaaaaggag aagagacaga gttagaggag 527941 taaaccgtgt gtttactcct cttttagttt tattgacatt ggtaaaacag agatagggta 528001 agaacttagc taattaagaa tgaaaattat aaggtttata agttggaaac taaatcaaat 528061 atgtcttcta agaatagatt tatgggtaaa agttgttttt acactattgg tgctactagc 528121 agtggcattt aagttatttt aatttcgtat taaatttagc ctttatcctt tcccattttt 528181 tatcttctaa tgtgagatca tacatacgga gtattttttc ttttaaatta aataagtcta 528241 ttggttcctc caaggagaat gcttttttat ttttatcaat tactcctttt atttcgccct 528301 taaaaccagg gaggatgaaa gtagagcagt tattgctatt cacccaagta gcccccattt 528361 cattaaggca gtatacgcta tcatagtaat tatcggataa catataaaag acatatgcac 528421 ccttaaaaag atgttttttt agatattcga aaatatcttc atctccagga ataccatgat 528481 aaggtgaaga agtgtatatt atatcttcag aagacactcc tatatcctct agtaattcaa 528541 cgaaagcatt acatacaatt ttgtcttttg aggagtggct aataaatatt tttttctcta 528601 attctctatt ttgatcactt gaaaagtgag ttatgctgct tttttcagtc tcatctacta 528661 caggcaattc atctaaaaat ttttttattt tattttctgt ttcatgatgt tcaaactcat 528721 taaaaacaaa ttcattttta tatatttcat tgcggtttcg tgcataccaa gtcttaagtt 528781 gttctagtga ataacgaatt aactcaatat catttgattc aagagatgtt cgaaattgat 528841 caataatatt tgtgagtaca ggctcgcgag agtaatctag aagtactcct ataattccat 528901 tagcctcaaa ttttaatttt tttaatgtgt ccattagatt tcctccgacc taatttaatc 528961 cattgtttgt aaacatttca tatctaatta tataacatag actcctattc taactactta 529021 ttttaaagca gtctggattg tttgggtaat tcataaaaaa ataaaagaaa gaaggaggaa 529081 tagagttttt cttttttttg tttgcaatgt tactgtcaag tcgcaaaaga attgctatga 529141 ccgaaaaaaa accgcaaagg aatagatata aggtaccttt ttgcaattca tctttgtaaa 529201 ataaaggtta ttctgacata atacaattaa tgtaaaaatt cgcacaattt tatgtaagga 529261 tgggggaatt ttcttgcggg gtgttttctt agataaagat aaaattccgt acgacttagt 529321 cacgaaaaag ttaaatgaat ggtatacatc aataaaaaat gatcaagttg agcaagccga 529381 gattataaaa acagaagtag agaaagaatt gttaaacatg gaagaaaatc aagatgccct 529441 gttatattat caactattag aatttagaca tgagataatg ctgagttata tgaaatctaa 529501 ggaaatagaa gatctcaata atgcttatga gactataaaa gaaattgaga agcaagggca 529561 attaactggc atgttggaat actattttta cttttttaag ggtatgtacg agtttaggcg 529621 taaagaatta atttcagcga taagtgctta tcgaatagct gaatcaaagt tgtcagaagt 529681 tgaggatgaa atagagaaag cagagttttt tttcaaagtg tcctatgtat attattatat 529741 gaaacaaaca tacttctcca tgaattatgc aaatcgtgca ctcaaaatat ttagagagta 529801 tgaagaatat gctgtccaga ctgtgcgttg tcaatttatt gtagcaggaa acttgatcga 529861 ttcattggaa tatgaaagag ccttggaaca atttttgaag tctttggaaa tttccaagga 529921 aagtaacata gagcatttaa ttgcaatgtc acatatgaat attgggattt gttatgatga 529981 attgaaagaa tataagaagg cttcacaaca tttaatttta gcgttagaaa tttttgaaaa 530041 atcaaaacat agtttcttaa caaagacttt attcactcta acctatgtag aagcaaaaca 530101 acaaaattat aatgttgctt tgatatactt taggaaaggg cgatttattg ccgataaaag 530161 tgatgataag gaatactcag cgaaattcaa aatattagag ggattatttt tttctgatgg 530221 tgagactcaa ttaataaaga atgcattttc atatctggct tcgagaaaaa tgtttgctga 530281 tgttgaaaat ttttcgattg aagtcgctga ttattttcat gaacaaggaa atttaatgct 530341 ctctaatgaa tattatcgta tgagtattga agcaagacga aaaattaaaa aaggggagat 530401 tattgatgaa aatcagccgg attctattgg cagcagtgat tttaagtagt gtattttcaa 530461 taacttattt gcaaagtgat cataatactg aaattaaagt tgctgcagat cgggtagggg 530521 catagcttag ataattggaa aagaggaaaa aagcttaatc ttttttcgaa ggttaagctt 530581 tttcttttat ttataaaaag tgaactaact atcagaaaga aattatatta aattttattt 530641 ttttgtttaa aaagtagatt atataaaggc aagctaggtg ggggaaaata tgtttaaaaa 530701 agaaaaagtc acagaataca tttggactat actaatacca acaatcatca cttttatcat 530761 tagttgggtt gggtcttatt acaatggtac ttcgacagtt agtattggac aacctacaaa 530821 agtttccggt cagtatatca cgccaataaa tataagtccc tatcatgata ttaaggaatt 530881 aagaataact tttccgcaaa aactagatgt aaaacaaatt agttcaaatg agcctataaa 530941 tgtaaaatca gataagaaca atataggagt tgaaagtaat tccacttttg agattgcgaa 531001 aatcgttgaa aataatagcg ttcagttgct aattacaaca caaaaaaagt taaacgataa 531061 ggaaattaga attgataaaa atggaaataa catttctgta aattatgaat ctcagattgt 531121 taatcctgca aaaaaacaat taatcaatct tataattacg tcatctattt attttataat 531181 gcttaatata ctagcattga ttatgaacaa aagatgggat aagtattatg caaaaatgaa 531241 aaatgaaatc aaagaatttg aggataatgc aaaagatctt gataaaaaat caaagaagaa 531301 aagcgaggaa ttatcggagc tgcgaaagac cttgaaccaa gcgtttgagg aaactgatag 531361 gataaaatat catgagaaga aaaaacaaat cctcctctta gctaagttaa acgattataa 531421 aaaagaacta accttttgga gaaatacaat aagaaaagtt ctttatgaac ttcctgatgg 531481 agataaaaaa gcagataaac taatagggac agttacatca tctttaaaaa cgtacggtac 531541 agtcgaaaaa aacgagcatg attatgaaag tttaaaagta gcagctgcct tactaaatga 531601 ttctgataag agatcgtaat gtactggatt ttaataaact attagaaaga agattagctg 531661 caaacatcag aacgaccaaa caatggtggt atgtttatag agtttagttg ttgaaaaggg 531721 cgaactatga gtttgctgcc catttactgc ccagaataaa taacaaatca tgaaaatcag 531781 tgtaaataaa ataacttaat gctataaata aaggcttttg taaataaaga tatgatttta 531841 ctaggttgag ggcctagtgg gtgaataacc cgtggaggtt caagtcctct cggccgcatc 531901 tcaataatac caagggttta accacctttg gtattatttt tttgtgtgga aaatacggct 531961 atgggagaag acttgctcac caaaactcac cagttactta aagtaagtca tccaaacggt 532021 cggcggttcc ttctgtttat taggaaaaag atatccgttc attgtaaaag aaacgaacca 532081 tgtcctattc gttcaaaaaa actaaagggt gatacatatt atacatgatt aatatgtatc 532141 acccttttct ttcttgttca acaatcgcgc ttgaggagaa cataagctaa tacaactgac 532201 tcgatttcta aagttgctcc attctttttt taaacaactc atccacaacc tgttttaaaa 532261 tctcgtacga ctgaatttcc ttgctcaatt cgtaaatatt agataacaca attaattcat 532321 ctgcgtgata catttgttgg aaatcaatta gttcgcgacg aattgtttct cgatcaccca 532381 tgattgtata ccccagtcga ctgtggagaa tttctaattc aaactgtgat aacgattcta 532441 ggaagttttc agtgggtgga ataagcttac ttaaattatt tgtataaata tcaatataca 532501 cctgcaaatg acttgcagaa ataaaagatg cctcgtctat agattctgct gcaatcacat 532561 taatgcaagc gatcacataa ggttcttgta aataagaaga cggttggaaa ttttctcgat 532621 aaatagagag cgcttcttcc atcgaatggg gtgaaaattg agcgccaaat gcatagggta 532681 aaccaagctt tgcagcaatt tccgctgaat ccgttgagga tcctaacaca aaaacaggca 532741 catgcgttcc aatacccgga taagcgcgaa cctcaccctg tacactctta tccccgacaa 532801 aacgcaaaat atcatttact tctctttcaa agaaaaacac tccattatgg ttggaacgac 532861 gaatcacatc ggccgttttt tgatccgttc cgggtgcgcg tcctaatgcc aaatctacac 532921 gatttggata taatgtttca agtgttccaa attgctccgc tacgattaat ggggaatgat 532981 ttggcaacat aataccccct gaacctacgc gaatgtcttt tgtatttgct aatatatgtt 533041 gtacaattga tacggttgct gcacttgcat aagcgtcgtg attatgatgc tctgcaaacc 533101 aaatccgttt atagcccata ttatctacag ctttagctaa tgacactgca gaatcaatcc 533161 cttgtttcat tgtttctcct tgtcttaatg gagcaactga taaaacagat atatcaaatt 533221 ttttcataat ttcacctcta aaataatgaa cttatacaag atcaatggaa aaaacatttt 533281 gaaaaattgt ttcatattaa atggtgtcca ttcctctttg atttgcatgc aaataaatat 533341 atactttctc aaacgatcaa tacataggca aaataaagtt atttcacaat ttcactttac 533401 ttttaaagtt ttaagcaaac ataaaaaaat gttcagtgaa caaaatatgt aaaatacatc 533461 ttatttttca gaaaggatac aagaaaatga ttgatgaaat agataaaaaa atacttgatg 533521 agctgtctaa aaatagtcgc cttacaatga aaaaattagg ggaaaaagta catctcactg 533581 caccagcaac cgcatcaaga gtagtaaagt taatagacaa tggcataata aaaggatgta 533641 gtatcgaagt gaatcaagtg aaattaggct tctctataca tgcttttctt aatatttata 533701 tcgaaaaaat ccatcatcaa ccctatttag cttttataga aacacaagat aactatgtaa 533761 taaacaatta taaagttagt ggagacggtt gctatttgct tgaatgtaaa tttccttcaa 533821 acgaggtatt agatcaattt ttaaatgact taaataaaca tgcaaactat aaagtgtcga 533881 ttgttattgg taaatagtta actttataaa acggagatgt gcggtcatat aacatgatat 533941 atatgctcta aaaaagccct aggttggata tggaatttac caagctgggg cctttttata 534001 cattataata acaagcgcat tattcatcag acattaatga agtattataa tgctttttta 534061 cttccttaat agacaaataa agctgatagt ttccatactt caataaatca ttcagaaggt 534121 gatttaaaac ttcttgtgaa tgaaccgtta ccttcagaag ataacatgca tctcccgaaa 534181 cacgatgagc ttcgctaatt tcattacgag tagcaataaa tttcaataaa tcatcatgca 534241 tatatgcatt catgaaaaag aagacaaagg ctgtaaaaga aaaccccatc ttcaattcat 534301 caaccacaat cgaatatgct ttaatgatac cgttatcctc catttttttg atgcgattgc 534361 ctaccgcttg tcctgtcata tgaatttttt caccgatttc tttccattgt atccgagcat 534421 ttttatttaa taattggaga atttgaaaat caattgaatc aatttgcata gtaactcctt 534481 tcacagtgaa aaagttttac aaaatagtat ttcatgagac catcgaaaat tcaatggaaa 534541 ttatatatcc ttatacagta taaaaatttt aagaggtgaa aaaatgacaa cagctttatt 534601 agtgattgat attcaaaatg attactttcc aaatgggaag atggctttaa caaacccaga 534661 gaaagcagca caaaatgcgg ctaaactact ttcacacttt agaaacacag gcgcacctgt 534721 ctttcatgta cagcatatca cagaaggtaa catcgctcat tttttccatc caaatacaga 534781 aggtgtcgaa attcatgagt cagtacgtcc attagagaaa gagacagtca ttgtaaaaca 534841 tatgccgaat agctttttca atacagattt aaatggaaag ctacaagaag aaggggttaa 534901 agaattagtt gtttgcggta tgatgtccca tatgtgtatt gatgcaacag ttcgttctgc 534961 agttgaacat ggttatgtat gccaagtggt agaagatgct tgcgcaacaa caacattgca 535021 aattgaagat aaaatcgttc ctgctgagca tgtccattac gcatttatgg ccgcattaaa 535081 tggtgtctat gcaacagtaa aaaccacaga ggcattttta aaataaaaga atttcctgcg 535141 cgaacataac gtctttcttt tcacaagaaa gatgattcaa caacttaaaa aaggatgttc 535201 agaaaaatac ttctggacat cctttattca ttatctttta ttgtttttca gtatcattat 535261 tcccatctga taaaagatca agatgtcctg tttttgatcc atagtaagac catatacagg 535321 gattgttttt gccataaata tagatattga tgaaggttta cataaagcac ctaattgctt 535381 gatttacttt aatgttagat ccctcaataa ctccattctc ttctaatttc tctactctag 535441 ctgtagctgc tgggcatgtt aaatgtactc tctcccagat ctttcattga attcggctat 535501 tatacataat ttctctataa ttttttatct gtttgatcta tttgaacgtt aattcctttc 535561 gaaaataaag tcaaagagtt aaaacacttt tttttatcta tgtattcgaa cactgctgat 535621 attatacact taactctgtc gatctaagac aaataaaaaa agaaagtgag ttgtaaatat 535681 gaatattaca caaattcgaa atgcaacaat tgttgtaaaa tacgcaaata aaaaattttt 535741 gatagatcct atgttagcag agaaaggtac gtacgctact ttccctgaaa cgatcagaca 535801 agatttattt aatcctttgg tgagtttgcc aacatcaatt gataacattc tggatggcgt 535861 agatgcggta attgttactc atctacacct agatcacttt gatgatgtgg caaaaaacgt 535921 attgccaaaa aacatcaaaa tgtttgttca aaatgaagca gatgcaaaag aagtaaaagc 535981 aagtggtttc aaaaatgtag aagtgctaca tcaagacact gtttttgaag ggatccaatt 536041 agtaaaaaca aaaggtgaac atggcagagg ggaagagtta ttaaacttaa tgggtgatgt 536101 ttgtggatta gtattcaagc acccaagtga aaaagtttta tatgtagctg gggatacagt 536161 ttggtatgat gctatcgaag acgagattca tacacatcaa ccagaaatca ttgtggttaa 536221 tggtggagac aatcaaagat tagatttagg ttcactcatc atgggaaaag aagacatcta 536281 tgaagttcac aaggctgctc ctcatgctaa gattatatct gttcatatgg aagctgttaa 536341 ccattggaca ctatctagag aagaattaaa aaactttagt aaagaaaaag gattctcaag 536401 taatatttta gtgccagaag atggcgagtc ttacacattt taatatgaac accgacaaat 536461 aaatagaaga agctcataat tataaaaact aatcatgagc ttcttctaat aatgaatatt 536521 ttaaatttta aatatatcga aaatcctaaa tatacggaat aacaaaaatg gaatgttcca 536581 atgatgacaa aaaaacttga aaagcaacaa agatgtgtcg ttaggaggta gaattcatgg 536641 taatgacaaa aaaagataca aatatatcaa cacagcagcc tctttggtta caaggttata 536701 ttgattcacc agaaaaacaa aaccaacttt ataaaaaaac attaaaaatc ttgatttttt 536761 cacaaatatt tgggggagca ggacttggag ctgggataac agttggggcg cttcttgcac 536821 aagatatgat aggatcggaa aatgtagcag gaattccaac tgccctcttt acttttggat 536881 ctgccgtagc tgccctgctt ataggagcat cctcacaacg ttttggtcgc agagctggac 536941 ttgcaggtgg tttccttata ggcggattag gtgctatagg tgtgataatc gcggctttaa 537001 ttaacagcgt tgccctatta tttgtttctc ttcttattta tggagcaggt atggcttcta 537061 atcttcaagt tcggtatgct gggacagacc ttgcaaatga gaaacaacgg gcaactgctg 537121 caagtatggc cttagtttct actactttag gagctgtagt aggtcctaac ttagttaata 537181 caatggggga atttgcagat tcaattggtg ttcccaattt agctggtccg tttattatgt 537241 caggagcagc ttttataatt gctggaatta ttctcttaat ttttcttcgt ccagatccgc 537301 tgtttgtatc aacagctatt gcgaatgctg agaaaaaaga cgataaagta caaataggag 537361 gaagtctaaa aaatcctgct atagacaaaa aaggaataat ggtaggagct gtcattatga 537421 ttttagctca actaatcatg acagctatta tgacaatgac accggttcac atgggtcatc 537481 acggtcatgg tttaagcgaa gtgggattag ttataggact ccatattgca gcgatgtatc 537541 ttccttcacc attgactggt ttattagtag ataagtttgg tcgcacaact atggctattg 537601 cttcaggtgc cacacttctt gccgctgggt tggtggcagc tattgcaccg gcagactcat 537661 tatcattgct aatcctagca ctagtattac taggggtagg ttggaacttt ggtttactaa 537721 cgggaactgc ccttattata gattcaacac atccatctct acgtgcaaaa acacagggaa 537781 cattcgatgt tttattagca ctatcaggag cagcaggtgg agccttgtca ggaatggttg 537841 ttgcacattc tagttataca atactatcaa tttctggagc cgttttatca ttgttactca 537901 ttccagtagt tatttggtat tttagaagga ttcaggaaaa agcataagct tatataactg 537961 tctttgaaga acctaagtag acattacttt accggaacct cctttttcta tttattatag 538021 taaggagttg acatggcatt agtggcatgt gtataactac acaattattt gggattcaga 538081 gagcatgtaa tgaacggaag agataattat ttatcacttt tattattgta cggtgttctt 538141 gtggcattaa gttcagtcaa ttttggtcta actgttttct ttttgttttc atcacctctc 538201 catattatta acaaacacga aaaggatttt aatgaaaata aaatgattag cgtatgtatc 538261 tctaattttc aaaatgaatg aatagtcctt tttaagattt acacacttat tctccaagga 538321 aaaatgactc aatttttcga ttttttatgt aaatcaaaaa agaatcatgt tagagtaggt 538381 gtgctgaaaa taattcaaaa aattattttg cgatatgatt aaagtaatat tgccagagag 538441 tttcaattgg acaaaattgt aagtgtttaa tacactgggg ctgcaatcaa atatgcacct 538501 ggaatcaatt gctaaacggg ggagtttata tgaacaacaa gaaaaatatc tttgatattg 538561 ttatgtacat tattttcggt gtgttaagtc tttttctagt tgcaaaaact gattatggca 538621 ctggagtttt agtgtttgtt gcaattttat acctcgctgt tattgcttat aaaattaagc 538681 aagtatttag taattcagat tcttaaggtg taacacaagg aggatttcaa ttgagaaaga 538741 aaagagttat tacttgtgtt atggctgcat cattgacttt aggctcactt ttacctgcag 538801 gttacgcttc tgcaaaggag gactctaaga caaccccttc ttacgaagaa ctagctctac 538861 attacaaaat gaaaagtgaa aagatttcat cgaacgggaa attagttgaa attgagtatg 538921 tgagtggaaa tgaaactcac aaagttcaga tgaacggaaa taatcatact gtaaaagtcg 538981 atggcataga acaaaaaggt ttaaactttg agtatgatga aaatgttgct aaaagaacaa 539041 attatgaaaa caataatttg aaatcaaatg aattcacaac acaggctgca aaacctaaaa 539101 agggatacca ttatgtgggg actttatctg ggcatacaaa agcagctaaa aatgcgttat 539161 cagttacaat gtcattagtc ggtattgtcc ctggcttggg atgggggagt aaggctgcca 539221 ctattttatt ctcttattgg gcaaaagaac aaatccctga tgcgtattat aaatatgatt 539281 tatacgaaaa aggagcaatg actgatagtt ggtatcagta tgctacagtt caattttttg 539341 aagataaagc tcataaaaag aaaatgggca aaccttggac aagtactcct gcaaaagtag 539401 atttacctaa tagctaattt taaaatcact ttgtctttat aaaggacaaa gtgatttttt 539461 gttatacaga agtaaaatcc ctcgtctgag gaatcttgga aaaaacttgg ttcaattttg 539521 atataacatg tttttttctt gctaatttag tttttctatg tatcgctaca cattctaaat 539581 aataagatat tagccggacg gttgatgcca agctcaaaag tttatatgga agtcaaagca 539641 taaaaaaggg tgttacaacg tgtagtcttc tttttatttt gccaacgtaa caagtgtgaa 539701 agtaatgatt tgtaggatca gttaagaaag gtttaagatt agatattgaa aaattttata 539761 tattttcaat aaaatactgg tactataata aatgtataca gattgtatgg agatgtaatt 539821 aattaaaaag gagtttttaa ttgcgttgga gtaaatggtt caatgttttt tgtatagtag 539881 cattgggatc aatatatggt tataaattat ttactaacca agaagtcagt actactcgtt 539941 taataatagc ttctgtaatt gtgttgtgga atattgttgg actttttagc aaagaatcag 540001 taaaacaagc acagcaagca aattaaaagt cataaagttg ggaaagaagg atgttactta 540061 tgtagtatcc ttctttatta ttccttgaaa aatgaaacaa attggagatt acagcttata 540121 taatcaattg aagtcgttga ttattttcat gaacaggaga tttaatgctt tctgatgaaa 540181 tattatcgta tgaatgttgc aagaggaaac gttactcaaa gattacaggg atgtgatgaa 540241 cactcctctt tatcgcactc acctgacccc aaattgttgg ggaagggcag gtacggaaga 540301 tagagtattt tttcttcgta acaaatcgaa aaggttggat aataaaaaac ttataatcta 540361 aggcggtata tagttgtgaa aaaggcgtta tttcttatat tagaccagta tgcagattgg 540421 gaaggtgttt acttagcatc tgcattaaat caaagagaag attggtcggt tcacactgtt 540481 tctttagacc ctattgtaag ctcaataggt ggttttaaaa catctgtcga ttacataata 540541 gggttagaac ctgcaaattt taatttgcta gttatgattg gcggggattc ctggagtaat 540601 gacaataaaa aactattaca ttttgtaaaa actgcatttc aaaaaaacat tccaatagca 540661 gcgatatgcg gtgcagtgga ttttttggcg aagaatggtt tgctgaataa tcatagccat 540721 acaggtaatt ttgtttactt atggaaagat tacaaacaat ataaaccgat tagcagtttt 540781 gtagagaaac aagcagtaag agataaaaat ttggttactg ctaatggaac tgcccctatt 540841 gaatttacta atttaatttt agagatgatt gattttgata ctcctgagaa catagagaaa 540901 atgatgtata tgaatcgtta tggtttttat catttttgtg ataaatatgg aaatccattt 540961 gttgattaat ttgctggaaa tgattttccc gaataggggg ctttgcgatt gagttgaatt 541021 tcctaataaa gcaaagaaag atgatttgag gtcaagttta acaaataatg ccatcaatat 541081 taatttgcag ttatttccga ttcctgatat aataaagaag aattattttt gttcggtgta 541141 aaggatagta tgaagattga cttttcgtct tgatgatact ttgggcaagg atagtatata 541201 ctgtgtggtt acacactagg aggcaacaaa aatggaacaa ggtacagtta aatggtttaa 541261 tgcagaaaaa ggttttggct ttatcgaacg cgaaaatgga gacgatgtat tcgtacactt 541321 ttctgcaatc caaagtgacg gattcaaatc tttagacgaa ggtcaaaaag tatcgtttga 541381 cgttgagcaa ggtgctcgtg gagctcaagc tgctaacgtt caaaaagctt aatcttcaat 541441 cgtttataca aacaggctct ttatataggg cctgtttttt tatgtctata tcatactcaa 541501 taaaaaaccc tactcaacgt tcgagtaggg agatgctaca aggtaataga aaaagattta 541561 aaacttcaaa ggtttgttta cagtataaca tactggattg acaatatgcg gaatgtatat 541621 aaattattta atgttttgtt caaatataga taactgactc tttttttcac taacctgttc 541681 gttcatttaa gtaagattag atgaattata aaaatggttt catctaaatg ttatcaactc 541741 gcatatctct tttatgagaa gaagataaac aattattatt caatgttgca gtggatataa 541801 gaaattctta aaaataatga ggagatcgat tgtttttttc tcctggaaat aatcacttag 541861 agatacctaa aacaatgaaa gccctacctc tcttccatcc ttacggctcc ttgtccgtgc 541921 cagtgtgaat caggatacta aaaaaagtga ctattttatt gagttttttg gtaaaacttc 541981 aatcttcgca gaagaaatgt aaataataaa aatggattag aatgtaggaa taacaaaaga 542041 ggtcgttaat gttctaaaca taagttggag aagatttgct tttcatcata atattccgaa 542101 atatcttttg ggatgtatct aaccaaaact ttttatttgt ttttcagtga ttcctttaat 542161 tacttccagt tcactaatca aaaattcata tgcattatcc agcatttttt tttcgcttgc 542221 attaagtgct ttttctttct tcatacgcat taaatcacgt acaacttcag caccttcttg 542281 tatttcacct gtttttattt tgtccgtgtt tattttgtac ctttgcttcc atggcagtaa 542341 cctatcggat tctccatgct gaaaaatgtg cataatgtgt tttaatgcaa gtatatcggt 542401 aactggtcgt atattcgaac tcaatatttt actcgttgga atcataactg tcatattact 542461 gattgacatt cttatgacat aatactgttg tttttcctct aagaattctt tttcttctat 542521 ggcttcaatt atacctgctc cgtgcattgg ataaacaatg ttatcgccaa tttgaaacat 542581 atcatccacc tccatatatg gtatccttct taagattacc atatatggag gtgtaatatc 542641 aaaattttaa taataacatg atcgaatttt tgatgtcaat aacttttttg aaaaaacaga 542701 tcaagcaaaa acaataggga acgtgtcgga tttccaatca ggaaaaggtc aattgatccg 542761 tgtgagcagt ttttcattgg ctcaatgaca ttacagaaat gatttgagta gataagaaag 542821 aacgatattc gtgaaatgtc agctaaaaat atttaaagca catgattaag ttctaatttc 542881 tttaccgatt tgatatggat aacggccgac ttacttaatg atgcattttc acttatcttg 542941 caagcagaaa aaggtttgtt gataaacatt tagccaccaa attggcatta ttatcaggga 543001 aattgacaac cttcaaatgg gtattgaggc gagaagaaaa ataaagaaag gagagattat 543061 aaatgaagac cagaacataa agaagtaaag gggaaagaac aaggttaatt gaaaagcaaa 543121 ctatataaaa tagtttgctt ttttttgtta tgacttcact tctttttctt tctctttaat 543181 gactaataaa acaccgctca gaattaaaaa cgaacctatc caaaatgtcc cgcctatttg 543241 ttctccaagc agaatccatc cgagtaaggt tccaaccaga ggctgaaaaa agaaaaagag 543301 gcctccactt gaggcattta ataattgtaa gccgtggttc cacaataaaa atgcacaagc 543361 tgttgaaaca attcccaaat acaaaaggcc acctagaatt ttagggtcaa gcagtagtgg 543421 cgtaaaaatc gtgctagggg agtaccatta acagggactc catttattaa tagaataaac 543481 tttatgaatt catttttttg tatgataatg gcgtcatatt catcgcttgt tgaaatttac 543541 ttatgaaata actggtactg ttaaatccaa cttgataaga cacttctgtc acattggatt 543601 cagggtgttg cagtaataat aagctttttt gaattctata atccattaca taacgtaatg 543661 gcgtcttatt cagcattcgt ttaaaataac ggcagcattc agaacggctc agttggccag 543721 cttttgcaat gtcctctaat gtgatttttt caacataatg gagatggatc cagtttaaca 543781 tttgtttcat tcgatgactt tttatcattt cagattgatc gtactctaat tgaaaaccat 543841 taacgaccag gtttttccac attaacgtta attgcatcgt aatgtcaatc tcatagagcg 543901 atgtcttttg ttgaatcaat tgatttattt ttttaacagc atctagaata ttttttgccc 543961 actgttgatt tccagccaaa aataaatagg gcaaattggt tgaaaacata tagggctgaa 544021 catagcttga atacagttcc tgagataaaa cgaaatgggg tgacacattc aagcaaatat 544081 acgtacaatc cgagccttcc ttttcttcgg ccatgtgcag gtagccgcta ttgataaata 544141 atccatcccc ttcgtgaacc tctatttttt cttcatttat ttgaaagaga gctatccctt 544201 ttagtatcaa aacaaattgg atttcatcat gccaatgaag cggaatatag ccatttatat 544261 tttgattgat cgttgtcttg tagcaggcaa ctggcaattc taccgttcgg tgctctgtta 544321 attcttttaa attttgatcg atcacaaaat tcttcattct gacttcacac ctcaatatat 544381 ttatattttt tcattcaatt tgagtatttt ttatcatgtt ttgcatttat tataacacta 544441 ttattatatt tattagtgag gagtcatgta tgaatacttc caatagaaga atgggattgt 544501 tctatgttat cacaggggcg acatgttggg ggattggagg cacagtagcc aaaaaacttt 544561 ttcaagaata tcaaattgat gtcaattggc ttgtaacgac acgcttgctt acggctggaa 544621 tgttactttt aatgctgcaa ctgttcagaa aggatcgttc ccaggttatt gaggtgtgga 544681 aacacaaagc gtcggctggc cagcttctaa tttttggcct attgggaatg ctagctgtgc 544741 agtacacata tatggcatcc attcaacatg ggaatgctgc cgttgctacg ttattgcaat 544801 atttatcccc agtaatcgtc attatctaca cgctgttgcg aaaacaaacg gttcttacca 544861 aacaagatat cataactgtt gtacttgctt tagtgggttg cttttttttg ttaacaaatg 544921 gttcaatgtc tcaactttca gtgccggcag ctgcagtagt atggggagtt ttatcaggat 544981 tcgcggcagc tttttatact ttgtatgccg ttggtttatt aaataaattt gattctcttg 545041 tcgttgtagg ttgggctatg attattggcg gttttgcatt gggttttatc catccgccat 545101 ggcaactgga ttttcaacga ttaactgctg aggcgtatgc atatatctta ttcgtgatat 545161 tatttggaac aatgattgcg ttctggttct tcataaaaag cttggaaagc ctctctccaa 545221 aagaaacaag cctactaggc agtctagagc ctctatcagc tgttgtaaca actgtcgttt 545281 ggttaaaagc gccatttggt tcttttcaat ggattggtgc tatttgtatt atagggataa 545341 ctttaatatt ggctttacat aaagagcctt ctatggagag tgaaaaatcg atattaaaga 545401 ttaggaatca tgcaaatcgg gatatatagg ggcttttttt gcttacatga ccggtccggc 545461 aatgaaaaac actggtggag tttgagccct ctcggcagta tcaaaaatac caagggtttt 545521 gacgccctag gtattttttc ttcaagaacc ttcaattttt cttctctgat tgaaaaacgt 545581 attacttttt tgtgattggt atccaaattt cacttttaaa agatggtgat gttacatcct 545641 tatgctcgtt ccacaatatt tctggacctt ctatttgttc gtaatttgac gatggaaacc 545701 attcggaata aatgcgtccc catacttctt gcagtgtatc cggaaatggc ccgattgatt 545761 cgaatacagc ccatgttgag gcaggaactt caagccgtga gaagttatct ggacaccgtt 545821 tcgttgtggc tgcgccaata tagtgatcga gctctccgtt ttcctctgtc cgaccttcag 545881 aaaaattcgt ggatgcacta atgaggcctg atggtgctac attagatagc tcttttagtt 545941 tatttattgc tttttcatct aaactttccc acatagatgc aatttccgga ttaattcctt 546001 tgaaaataat aggaactctt tttttaatgc caacgatgcg aaatgcctct ttttcttcaa 546061 tacggtagtt catttcattt cctcctttaa ttgttagctg gaaggtcatt cgtggataag 546121 ctttaaggga atggccatta aatctggctt ttgatgggtt tatgccatgt aaattttgga 546181 atgcccgtgc aaaagaatct ggtgagttat aaccgtactt tattgcaata tcaatcactt 546241 ttacattgct gtctttcagt tcaaaagctg caagagtaag acgtctgcga cgaatatatt 546301 ccgataatga aatacctgca aggaaggaaa acatcctttt aaaatgatat tcagagcaga 546361 aagcaagctt tgctgcctct tgaaaatcaa tatcattagt gaggttttct tcaatatact 546421 ttaacgccct attcatactt ttaagcaaat ccatttattt ggcctccttt aaccaaagaa 546481 taacaggagt gaaatgtatt tatccgacat tctgtgcaca gttttgcagg atgacttata 546541 tgaaataaag taagtgattc acttgtattt gtacaggttt tattgaagca tgctgttcat 546601 aaaaaggcat caataaaaga aagttataat tgtcttataa acggcacatt catataattg 546661 agtgaaaaag gatgcgtatc atgcctatca attcttttga aaattatccg atgagctgga 546721 agccatcgat tgataaagct gaaaagccta tttataaagc acttgcaggg caattggaac 546781 aggatatttt aaacggagtt ttattacctg gaacaaaact tcctccacag cgagaattgg 546841 ccgattatct agatttaaat gtgagtacga tttcaaaagc atttaaagtg tgtgagttaa 546901 aagggctgct gagtgcgact gtagggagcg gcacatttgt atcgtatgat gcgttgtcga 546961 atgcgtattt acttgaggat actaagccga cacatttaat tgaaatggga gcaatacttc 547021 cagatcacgc ttcatatgag cccttgttat accaactgaa aaacatggtt catgaggagg 547081 attatgaaaa atggtttagc tatggccggg caggtgaaag cctttggcaa aaagatgcag 547141 ctgtaaagct catccaaaga ggcggatttg aaacatccgt tgatcacatt ttatttgcaa 547201 atggagggca aaatgcgatt gcagcgacat tggcgagtct ttgtaagcct ggagatcgca 547261 tcggagttga ccatcatacg taccctggat taaaaactgt tgcatcattg cttagtgtgc 547321 aaatcgtacc gataaaatca gaaaacgatg aaatgagtcc ggagtcactt gaatatgcgt 547381 gtaaaaacga aaatattaaa ggtttgtatt taatcccgga ttatcataat ccgacgactt 547441 cctttatgtc tgttgagaat cgaagaatgg ttgcagacat tgtaaagaaa tataatctgt 547501 ttgttattga ggatgcatcg taccatcttc tcaacaaaaa tccgcttccg gcactcgcct 547561 cattcgcacc gcaacaggtt attcatattg caagtttatc aaaatcgtta gcgccaggcc 547621 tgcgtttggc ttatgtagca gtgccgagac aatataagga gccaatatca aaggcgcttt 547681 ataatttaaa tataactgtt tccccgctat tagctgaact tactgctcgc acgattgtat 547741 caaatcaatt tgaagtctta attgagagtc atcgtgaaca aaccattcgc agaaatcaac 547801 tcgtaaaccg atatgttgcg ggatatacat gtttaggtgt tgaaacaggc atttttcgtt 547861 ggttgttgtt accgggtaaa atgtctggtg ccgaatttga agaattggct gctcgacttg 547921 gcgtgcaagt gtatgcggct gaacgctttg tagtgggaaa tagttgtcct gaaagggctg 547981 taagggtttc tgtctgtgca ccaaaaacac ttgaagagct tgaacaagga ttaatgatcc 548041 tgagacgttt gctagacgat cttacctaat attgtttgcc atacaattat gacattgtat 548101 ggcttttttg tgcgtgttat gatgatccac atctagaggg aggtttatac aaaattggct 548161 tttagaaagg aaggtcagat gatgttagac aaggacagcg taaaagcaat agatgttcaa 548221 actgcttcat tacagagcta catcagttca ccagaaaaac aaaaatcgtt atacaagcgt 548281 acactattcg ttgtgagtat ctcacaaatt tttggcggtg cggggctggc ggcaggagtg 548341 actgtcggtg cgcttattgc acagcaaatg cttggcactg atgcgtttgc tggtttgcct 548401 tctgctttat ttactttagg gtcagcagga tctgcattaa ttgttggaag actttctcaa 548461 cgttatggcc gtcgaacagg tctttcagct ggctttatga ttggcggact tggagcaata 548521 ggcgttatta tggcagcaat cataaatagt attttcttgt tatttatttc gttgcttatt 548581 tacggtgcag gtacagccac taatttacag gcccgttatg caggtacaga cttagcaaat 548641 cataagcagc gagcgactgc tgttagtata accatggttt ttactacatt tggcgcagtg 548701 gcaggtccaa gcttagtgaa tgtgatgggg gatttcgctc tttctattgg tgttccatca 548761 cttgctggcc ctttcatttt agccgcagca gcatatatgt tagcaggtgt ggtccttttc 548821 attatgcttc gtccagatcc attagttata gcaagaacaa tagaagcggc aaatgaagag 548881 cctggtgata aaggacattt ggcggcaact gagcatacag aaaacaaaaa agggataatc 548941 gttggggcaa cggttatggt tcttacccaa atagtaatgg tagctattat gacaatgaca 549001 ccggttcata tgagacatca tgggcatgac ttgggtgcag tcggtcttgt tattggtttt 549061 catataggtg ctatgtatct cccttcactt gttacaggtg ttcttgtaga taggttggga 549121 cgtaccgcaa tggctatttc ctctggaaca acgttgcttt tggcaggtgt aatagcagca 549181 tttgctccgg gagaatctat gattcttctc gtcattgctc tttctttact gggattaggg 549241 tggaattttg gtttgataag cgggactgcc cttattgtag attcaactga tactgccaca 549301 cgagctaaaa cgcaggggac agtggatgtt ctgattgcgt tgtcaggagc tgctggcgga 549361 gcattatctg gaatgattgt ggcaggttca agttacctcg cattatcact tattggaggg 549421 attttgtcct tattactcat tccggtggtg gtatggtcta ggggccgcta aagggtagga 549481 ttgtttaatt tacattaatt tgttatattg ttagataaag tatattgcag catctaatat 549541 tctaacgaac tatagttgct ccattaaatc tattataaag atttgaccag gattccttat 549601 agctgtgtca ctcactgcat attctttaat tgaatcacat aaaatggtta tcggatttga 549661 aaaaggcagg attactcgct ttaggtaaag gagtcataac gttgttaaaa aggttttctc 549721 ttgttattgt tacactaatg atgtctatcg ttgttgtttt agcggctgct aaagagtcgc 549781 ctggagatca tgtcatctca tttgatgaac ctattatctt gatgatctca attggaatcg 549841 ttgtattttt attgatccct ccattagtca tgtccttttt tggcaatttg gttgtaagaa 549901 taatatctgg tgtataccaa tgttttatcg ttttcacttt tctggggctc attccaattg 549961 gatttcttat tcccaatggc tttttgacaa ttctagtttc tattgcagga actttagtca 550021 gtatagctag tgttgccgta accttatgca ttggcaagaa taaaaaagat atataatcat 550081 cgaattgtta ttttttcaga ttgtcagtga aataattata caaaaagaga aggcttgtgg 550141 gccttctttt tttgttgttg catcatcccc actttgagct taatctattg aataataaga 550201 gaaggaacct atagaagaat aaaataaata ccgagatgtc aaaaataaaa ctggacttca 550261 ttattgtgaa ttcacgtaaa tgtaaaaaga ttggaaagag gggaattcct tcatgacaaa 550321 tagcagaaca aatccgaagg ttgatgaatt tttaagtaaa gcgaaaaagt ggaaggaaga 550381 atttgagaag ttgagaacca tcattcttga ctgtgagctg actgaagatt ttaagtggat 550441 gcatccttgt tacacatatc ataataaaaa tattgtttta atacatgggt ttaaagaata 550501 ttgcgcgctt ctgttccaca aaggcgtctt attacaggat acagatggaa ttctcattca 550561 acaaacggag aatgtacagg cggcgcgcca gattcggttt acaaatgttc aggaaataaa 550621 tgagctagaa aacattttga aagcctatat tcacgaagcc attgaagttg aaaaagccgg 550681 tttgaaagtg gatgttaaca aaaatattga attgaacatt cctgaagaac ttcaaaataa 550741 attcgatgaa atccctgcat tgaaaattgc ttttgaagct ttgaccccgg gacggcaaag 550801 agcgtacact ctttattttt ctcaagccaa acaatccaaa acccgagaat cgagagtcga 550861 aaaatatgtg caaaaaattc tcgatggaaa gggattaaag gattaggcac gccaaggttc 550921 aggctaaagg aatagcatca tagcgtaata agatcatttc tatagaagaa aaacaagcat 550981 agtaagatgc ttgttttttc ttaggacaac attcacttac tgctgaaatg cttctaacat 551041 tgtatgccac tagacagcgt tataaaatat taatgcaaca cctagaaatc tatccaatga 551101 aatagctcaa tggtatggct cattacattt agaatgccta ggagaactaa tagaaccgga 551161 agatttttag caagttacta cactccaaac tttgtttttg tattaatata ccttattaac 551221 cattgttttt agtcaggtgc agacaaacga atactgatta atgaatcatc atgatatcaa 551281 tgagccgctt gattttttca tcgtcgcctg tatcaacgta cactgttttt ctgtttttta 551341 tgatactctc agtcacttcc cgcatgacgc ctttttctat atcatcagcg gaatcccagc 551401 gtaaaggcac attatataca tgaattgtgc catccccatt gccatgataa gtgactgatc 551461 catccactaa acgagaacct gccaactggg tcacattttc tggatagctg gcacttgtat 551521 catcattagg attaattggc tcgccagccg caatatgtcg aacatttaat tcatctatct 551581 cttgattagg tccaagttga agccaaactc tggcatattc aattttttcc gaagagtatg 551641 ctgccaatac attgtcttct ttgcttttct cttctgctga agaggtatca tttgcagctt 551701 ttgttgcgga ttcttctgat tctgttattg gctccgcttc atccttgcgt attttggtgc 551761 tctcttcagg ctcagtgtgt ttttcgtcag tttgcacagc agaagcttga tttgaaggtt 551821 gttgtgcttc tccatcctta ctgtccgtac atccagcaag caaaatcata agcagcaggg 551881 cagtattgca ataacatatc tttctgcgtt tcttcatttt ttcattcctc tctattaatt 551941 caggtcagct tcatatataa gtttatgtat ctaaatatta ccatggaata gataggatga 552001 tattgaaaac tgtttaagaa gaggaaacga tcttgaatag catcgcgaaa acctaagaat 552061 cttaagaagt tttgcccctt tttcttcagg tattgaatgt aaagtgggat ataaatgcaa 552121 acaaaaacga aatgccttat ccacctcgtg tcatggcaga aaaagtgggg gatttattag 552181 agcggatttg ataatggcgg caggtaaatg ggtgttgact tatatgtcta agcgggagac 552241 tcaagtctgc tcgatcgcat acaaaatacc aagggccagc aacccttggt atttttatac 552301 cttcatgcat ttttgaagtt tatgcttaaa ggtctgcctt actttgcaaa tcgccgagct 552361 gctgcaacgc acatgataac ggcgatattc actgctacga gtgcccagcc cactttctcg 552421 tgcagaatca ctgaggcaag cagcagtcca aaaaaaggct ggagaagctg gagctgccca 552481 accgctgcaa ttcccccttg ggcaagacct cgataccaga acacgaagcc aatcagcatg 552541 ctgaataagg atacatatgc aagactgagc agtgcgggaa cgccgatcgc cgaccatgag 552601 tccggcgtaa aaaagaacga caatggcagc ataagaggaa gcgacagaac gagtgcccat 552661 gagatcacct gccaattccc cagacgccgt gaaagtttgg ccccttctgc ataaccaaga 552721 ccgcatacga caatagaagc cagcatgtac gcgtcgccaa gcggggatga acctcccccc 552781 tgaatgaggg cgaaacctgc tactaacaag ctgccggcag ctgagaaaat ccagaagacg 552841 gggcgagggc gttcaccccc gcgcagtacg ccgaagactg ccgttgcgag tggaagaagt 552901 ccaatgaaga caatggcgtg tgcggatgtg acatgctgaa gcgctaaagc tgtcagcaac 552961 gggaaaccaa tcactacgcc gaacgctacc actaacaatg aaatgagatc tcttttggca 553021 ggatgctgct gccggaagat gagaaggaga cctcccgcca gtacaccagc tatcgcagca 553081 cggcaaactg tgagaaataa cggatcgaag tctgacacag ccaaacgggt cgcaggcagc 553141 gagccgctga aaatgagtac gcctataaaa ccatttatcc agccatttgt tgttttgttc 553201 attataatca ctccacatat ctttcttgtt cattgtctgt attttcttaa caaaaccagc 553261 agctaaggat tacaatgact ataaactgga attggccttt tataaacagc cagttttcat 553321 aaaaaaatgc ataccagtta ggagaacaac gcgcaaatgg atatcacgcc ttttttgaat 553381 agaactctgg atattccgct ttatcagcag ctttatcggt attttaaaga aaatatgcat 553441 cggggccgta ttcaaaaagg aatgaagctt ccttcaaaaa gactcctggc gaatcagctt 553501 tccatcagcc aaacgactgt agaacgtgcc tatgaacagc tcgctgctga aggttatatt 553561 gtgagcaagc caagaagcgg gtggtttgct gattatcatg attctgattt tgcttatgat 553621 agaatgccaa gcacaacacc cattcaacaa gaagcagaag aaaataaaca atggattgat 553681 tttcattatg ggaatgtaga ttcttcttac ttcccttttt ccgcatggcg aaaaagcatg 553741 gtcaatagct tagaccaata tggacacgag ctttatcggc cgggacatgt tttaggagag 553801 tttgagctga gaacactcat tgcagagtac ctgtatcaat ctcggggggt tcattgcggc 553861 cctgaacaag tgattatagg tgccgggaac cctattctgc tgcaaatctt gtgccaagtt 553921 tttgagccga atatttctat agggtatgag gatcctggtt atccaagagc acgcaagatt 553981 tttgaagcca accgcatgaa tattgttcct ataccagtcg atgatgaggg aatctgtata 554041 cagaagatca aagaacagca gccaaacctt gtatatgtca caccttccca tcaatttacg 554101 ctgggaacca taatgacaat aaacagaaga attcagctgc tcaaatgggc ggccgaaaat 554161 caatccttta tcatagagga tgattatgac ggggaattta ggtacacagg acagccggtt 554221 ccttctctgc aagggcttga tcagcataac cgtgtcattt atatgggcac tttttctaag 554281 tctcttttgc cctcgctgcg tatcagctat atgattcttc cttcgcctct tttaaaaaag 554341 ggtcatgaaa tcacgtcctt atataagcag acagtgtcct gccacagtca gctaacccta 554401 gctgaattta taaaaaatgg agagtggcaa aaacacatca acagaatgag aaaactttac 554461 cgcaaaaaaa gagccattgt attagaggca gtgcaaaggg aattaggaga gcatgtcaga 554521 atccgcggag aaaactctgg gcttcgtatc ttacttgacg tttatttgcc atttggtgaa 554581 aaagagttaa ttgagaaggc gaaaaaacat ggagtaaaaa tttatcctgt ttctctttct 554641 tatcaacatc atcctcctac aaaaacggtc tcgctcgggt ttgcaggggt ttctgaatcc 554701 gacataagag aaggcataaa aaaactgaag gctgcctgga agatatgagg gagctttcag 554761 tttagcaaaa cggccaagtg acgactaagt gttgagagct gttcaatatt ttttaagtat 554821 atgatgagtg cctgcagtcc aggccacgat acgtctgttt agcgaaaaac agaatttttt 554881 atttgctcct cacagtgcta aaataaacaa aatagacaat tgaaaaaata gaggtgtaag 554941 aatgaagtta gatgagttta caattggcca ggtcttcaaa acgaaatcat taaaagtatc 555001 aaaagatgat attatgcggt ttgcgggtga atttgaccct cagtatatgc atgtagatga 555061 agaaaaagcg agtaaaggca gatttaatgg aattatcgct tccggcatac aaacactggc 555121 catatctttt aaactttgga ttgaagaagg tttctatgga gacgatatta tagccggaac 555181 agagatgaat catatgacat tcataaaacc cgtatatccg gatgatgaat tgtttacaat 555241 tgttgaggtt cttgataagc agccaaagag aaatgaattg ggaatactca cagtattgct 555301 atctacttat aatcaaaaag aagtaaaagt gtttgaaggt gagttatctg tattgatcaa 555361 acgataactc agaaagcccg cttttcgcgg gctcgattga agcagatggg tgaaagatgt 555421 tagcgggttt cctttgaaaa ataagaggtt aaaacatcat aaacaatagg caaagaagta 555481 aatccctcat cttctagaaa atgacctccg tgctgaactt catataacgc agcatcaatt 555541 tgttgtgcca gatccttgct gaatgaaaaa ggcacaattt ggtcgtcctt agaagcaatg 555601 acagcacggt gcttcgcgga ctcgatgatt ttttgatgat caaacgatcc ctgtgtaaat 555661 tcatctaaca tctgtaaagt gggcaatgat ttggcaaagc cggaaacaag tatgattccg 555721 ccaagctgtt ttcgtaattg aagatgttcc aaaaatctca aaatggcggg gcaacctaag 555781 ctgtgcgcaa ccaaatacgt attttcatgt aaagtgtgct gatataaaga gagtgtatcc 555841 agccaatcct caagtcttgg ctggagcgga ttaggcatgt ttaaaatgtc tgcttggacc 555901 ccatctgcga gcagacgttt tttcagccaa gggaaccaat gatttgttga ggaggctctg 555961 tagccatgaa tgatatagac ttgttttgtc attatttcct cctaagaaat attttcattc 556021 agtataaaat tcctctcatt gggaaacaag tacgcacttt tttgtaagta gctttacata 556081 tgaggccctc cttgtgccat tccccactta cacatctcat ctatgagggg atacaaagat 556141 cgccctctgt cagataacga atactctact ttcagtgggg tgtgagaaac ctcagaccga 556201 tgaataaggc cgtcagtttg caattcctta agctgtgcgc ttaacatttt atgggtgatg 556261 aagggcatag cccttttcag ctcgccgtat ctcatcgttt tttcacaccc taactcatag 556321 agaattctca ttttccattt gccccctata agagataagg tgtattcaaa tggggcttgt 556381 ttactgcggc acaggctatt cattgtaatc aaacctcctt ttttaagtat catatcagaa 556441 taaattagga ttttcggtgt tgaagtttga gggcgattca cgatctgaag tgaaaggggc 556501 cgcttgctca acaggcggca cggtacatga atgttctaag tcaaagaggg ttaccttact 556561 gttagttact ttatttaaaa aaacgcatgt ttttagctga aaatatctat tatggtatat 556621 ttaaatataa agaaatattt gagaaatgag gaatggtatg aatacaccca aaaaacataa 556681 gaaatttaaa gcgaaaatga ttctccaaat catcatggtt atcattggag gaatcatagc 556741 ggcatatgga ctagaaacag tgctcattcc aaacagtgta tctgatggag gggtgacggg 556801 tcttagcatc gttggttcac agctattcaa cttgccgctg gggattttga ttgctgtgat 556861 caacattcca tttgtctggt taggatataa gcaaattggg aaaagctttg cattattatc 556921 aattatcgga atcgtatcgc ttgccgcggg gacaagcttt ttccaccaca cacccgctat 556981 catagaagga gataccctgt taattaccgt tgtcggcggg attatccttg gattcggaat 557041 ggggctggcg ctgcgtaatg gcggcgcatt agatggaatt gacatgcttg ctgtgctgct 557101 atcccgaaaa ctgccattcg gaacgagcga tctcattcta ttcttaaacc tatttgtgtt 557161 tatttttgtt tccacagtat ttggcttaca aggggcattg ctttcagtca ttgcttacta 557221 cattgcatcc aaagtgattc atgttgtgga ggaaggctta agcggctcta aaacctttca 557281 aattattaca acccaacctg aattaatggt agagacaata cgtgatcaat taggccgaag 557341 cgccacatat aaagaagctt acgggggttt ttcccacgag aaatttaaag aaatcacatg 557401 tgtcatcaac cgtttagaag aaaccaaact aaaggaaatt attaatgata ttgataaaac 557461 tgcctttgtt accgtgtatg atgtagctga agtgaagggc agcaatttta gaaatcttaa 557521 tcatcactaa aaaatagaat gaccttttta accgtaactg acatgccgcg ggtaatttaa 557581 tcaaaaacac ttttttgagg cttgtgggtg aataaccggt gaaggtctga atcacagaaa 557641 taccaagggc gtcaaaaccc ttggtatttt ttctggttat tagattttat cttcagcttt 557701 acgtgctgct tcgagcttat caatcctgtc tttatatttt tctccccagt ccttcatgtg 557761 caggataaca ggttctaatg ttcttccaaa ctcagttaaa gagtattcga cttttggagg 557821 gacctgttta taaacctcgc ggtgaatcac gccatcccgt tccaattctc ttaattgtag 557881 cgtgagcata cgctgggtaa tttttgggta tagttttcga aactcattaa acctcttttt 557941 accgtcaatg agatgataaa gaagaatgcc tttccactta cctccgatga tatctaatgt 558001 tgtctccacc ggacatcctt caaagtcatc agaagaataa tcaatgccga gtttacgatt 558061 tctcaagctg ttcactccta atagtatact ttttgatact atatacattc aatgtgcgta 558121 ctttttatat tttaatatac atcatataat gatgtcacat ctaaggaatg aaaggaatgg 558181 atcatatgaa aacactcgta ctcgttgtac atccgaatat agaatcctct cgtatcaata 558241 aaaagtggaa agaagccgtt ttaagtgaac cagatgtaac tgtccatgat ctttatgaaa 558301 aatatcgcga tcaaccaatt gatgtggaat ttgaacaaca gcagctcctg gcccatgacc 558361 gtatcgtttt tcagtttcca ttatactggt acagcagccc accgctttta aaacagtggt 558421 ttgatgaagt gtttacgttt ggctgggctc atggtcccgg cggaaataaa ttgaagggga 558481 aagagtgggt aactgccatg tccatcggtt cacctgaaca ctcttatcaa gccggcggat 558541 ataacttgtt ttcgataagc gagctgacaa aaccgttcca agcatctgcc catttagtag 558601 gcatgaccta tctgccttcc tttgccgaat atcgcgccaa tacaatcagt gaccaagaaa 558661 ttgccgaaag tgcgaatcgg tatgtaaagc atattacaaa tatagaatta aacccgaagg 558721 ttcgcctgca aaggtatttg aaacagctgg agagtgtcga tttaacataa agattgattt 558781 ttgaaaatcc tgtactcacc aagcaggatt ttttcttgtt cagcagaggg attttaacat 558841 atagcaaaaa aagaagaagc caccaaaaat aagctatttg cttggtcctg actgcttatt 558901 tttggtgaaa tacttatttc tctgtgatga aataaagcaa agcgatgacc ggaaaagcga 558961 ttccaatcca taatgctgta ctccatccgc ctgaggcata tgcccatcct ccaattgatg 559021 accctatcgc accgcctaga aagaagatcg ccatgaataa tccgtttaat cgactgcgaa 559081 tttcaggcgc caacgaaaaa atagcacgtt gactgagcac aaggtttgca gatacaccca 559141 tatctaacag aatagcagcg gccactagaa ctgttatacc gacgggggag ctgctctgaa 559201 tcatgagcgg cagtaataaa gagacaacga caacaccgag agcgattcca gtggcaagcc 559261 tggttaagcc tcgatcagcc aggcggccgc ctattggtgc agtgactgca cccgcaatgc 559321 ccaccaatgc gtagagtgct attgccttct gagaaaaatg aaaatcagga ccggacaata 559381 ataaaggaac agttgtccag aacaagctga aagctccaaa tacaaacgca tgatagatgg 559441 cacggcggcg taagactgga gtcgtgcgca gcagcttcca cattgaaccg agtaaggcag 559501 tatagtttgt atttgctgtt ggttttctgg caggaagcac ttttgataat acgatggcca 559561 ggataacact taccacggcg gacaaagcga atattgcatt ccacccccag atatcagcga 559621 ctagactaga tatcggacgg gaaagcataa taccgagtaa taagccgctc atgacattgc 559681 caacaacccg gccgcgtgca gcgtctgatg caaggtatga tgcaaatgga acaagcactt 559741 gggctgcgat tgatcccaat ccgacgaaaa acgcagctgc taaaaacagt gttccatgct 559801 tcacaaatgc tgttagtgtc aaagccgctg cgcttagaag gagcgataca acaataagtt 559861 ttttgttttc gataatatct cctaaaggga caaggaatag taagccggca acgtatccga 559921 tttgggtgag tgtgacaatc aatccagcac cgcttggaga aagtccaatt gccttactaa 559981 ttaatccgac caagggttgt gcatagtaaa gattagcaac aatgataccg catgcagttg 560041 cgagaagaag ggttaaactg ggtgaaatcc tctgacctgc ttgtttgttt ccattagcca 560101 tatgaatgaa ctccttttta agtggttttt tgagtgtaat catgacttct cacaagtgat 560161 tttataaact gaacgttcag tttcgtcgat taataaaaat aatatactaa acgttcagtt 560221 ttgtaaatgg atttctgttt tcttttttta ttcaatttaa gtatactgaa cgtatagttt 560281 atattgcggg aaggaatgat ttatgtgcag agtaaacgag ggcggccgcg tgatgaagga 560341 acgcataagg cgattctctc tgcagcctat gacctattgc tggaaaaagg cttcgatgcg 560401 gtgacagtcg ataaaattgc cgagcgtgcg aaagtgagta aagcaacgat ttataaatgg 560461 tggtctaaca aggctgccgt tatcatggac agctttcttt cgaccgcgac ggacaggctg 560521 cctgtgcctg atacagggtc gtcagtacaa gatatagtaa cccacgccac gaatttagct 560581 aggtttttga caagccggga aggaaccgtt attaaggaat taataggtgc agggcagttg 560641 gatgaaaaat tggcagaaga atatcgcacg cgatttttcc agcctcgccg cctccaagcg 560701 aaaggccttc tagaaaaggg aattcagaaa ggtgaattga gagagaatct tgatattgaa 560761 gtaagcatag atctcattta cggaccaatt ttctatcgtc tgcttataac aggggatgag 560821 gtgaatgatt cctatgtgcg tgatttggtg atgaatgcgt ttaagggagt tcaagctacc 560881 tctgctacag agagtatgta gctgataaga actgcaaaag ctgcggatta tatgacaaat 560941 tggttccatc gtacagtgaa atataagatt tttgttgctg agcggaatca tcgagggaaa 561001 agttctctta tcggatgtcg aaaaagaagt cattcaatcg tgaatacata acatcatatt 561061 attacattcc ttttcatcga ttggaacaag ggttctatac ttcaatggaa taccgcaaag 561121 ttggagtatt taaacaacag gggaaaatcg atggccatta tgtaggtgtc atggcaatgg 561181 aaaaaatact tgcaatgtaa acaggcctct aaagagacct gttttttaat atccagatga 561241 ttgtctagtt tcagcttggg ctctatgacc actcccataa ctgaaatagt ctaatattta 561301 taccagaagg gattgtttat ataaataaaa gtttatataa tgacgggggc gctaaggaaa 561361 cgcggggagc gactcaggtt ttcgtttcaa agttttgatc cttaagatat acggagcgct 561421 acatatggaa acgtaaaggg gaatgtataa tcatttggcg tgtatataac gatttgctta 561481 tatattgatt tgggaaggag gagctcatat gacgattgat gttgcggcga tgactcgttg 561541 tttgaaaaca cttagtgatc aaactaggct tatcatgatg agattatttc ttgaacaaga 561601 atattgtgtc tgtcaattgg ttgatatgtt cgaaatgagc cagcccgcca taagccagca 561661 tttgcggaaa ttaaaaaacg caggttttgt gaatgaggac agaagaggcc aatggcgtta 561721 ttattcaata aatggttcct gtcctgagtt tgatacattg caattgatct tacatcaaat 561781 tgatcaagag gatgaattgt taaaccatat caaacaaaag aaaactcaag cgtgttgcca 561841 gtaaggaggc attagattga catcaatgat tttggcagta ttcatctttt tattaactct 561901 agtattggtc atatggcagc cgaaaaattt atctataggg tggtcagcct gtggaggcgc 561961 agttttagct ctaatagcag gtgttgtcaa ttttcatgat gtgttaactg tgacagggat 562021 tgtttggaat gcgaccttgg cttttgtggc catcatactg atatcgttaa ttcttgataa 562081 tatcggtttc tttgaatggg cagcgcttca tatggctaag gctgcaaaag gatacggtgt 562141 gcggatgttc gtttatgtat ctctattagg agctatcgtc gccgcgttat ttgcaaatga 562201 cggtgcagct cttatattga caccaatcgt attagcgatg gtcagagcat tacattttaa 562261 tgaaaaatta gtttttcctt ttatcattgc cagcggattt attgcggata ccacttcgct 562321 tccttttgta gtaagcaatt tggtcaacat tgtttcagcg gactattttc atattacgtt 562381 tattgattat gcatccagaa tggttgtccc gtacctgttt tcgctgctgg cgagcatcat 562441 tgtactttac cttttcttta gaaaaagcat accaaaacgc tatgatctga ctgaggttaa 562501 aaaacctgtt gaagcaatta aagatcaaaa catgttcaga ctgtcatggt atatcttagg 562561 gctgctgtta attggatatt ttgcaagtga atttttttct atccctgtat cagtggtagc 562621 gggcagcatt gcaatcattt tcttaatcgc tgcgcaaaag agtccggccg tccatacaaa 562681 gaaagtggtg aaagaggcgc catgggctat cgtattcttt tcaattggca tgtacgttgt 562741 tgtgtatggt gtccgaaatg ccggattaac ggatgtcctt tcagatgtga ttcaagccgc 562801 agctgatcaa ggattgtttg ctgggacaat tggaatgggc tttattgcgg cgattctttc 562861 ttccattatg aataacttgc cgactgttat gattgacgca ttggccattg ccggtacaga 562921 tacacatggg atgatgagag aagcgcttat ttatgcaaat gtgatcggtt cagatttagg 562981 gcctaaaata acaccgattg gttccttagc gacattatta tggcttcatg ttctttcgca 563041 caaaggtatg aagatttcct ggggcacgta ttttaaaaca ggaattatcc tcacgatacc 563101 cactttattg atcacacttg tcggcctgta tatttggctg ctgataatcc attcttgttt 563161 ctaaaaggac aaggtcacta tatcaaggaa aacaatgcac tggtaactct tgccgcagcc 563221 aaatggctga agggtggggg agaaaatacc ttggggctaa gtggaatgtg tacagcgcag 563281 gaatcgaagc tcaaggatga catcgagtgc tgtcaaagca atgaaagaag cagggattga 563341 tatttcaaat caaacatcgg agaaatttga tgatccggca aaagcacacg gaacagaaga 563401 agtgtttcca aagggtccgt gatgaaattg gtgaccgttt aaaacagttt gctgtaactg 563461 gggaataaag aatcgatata ttcagcgttt tcttgggtta tataatacaa tgtgttgttc 563521 aacaggtgtc tgcgagctga gtgcagacac ctgtttttgt ttttatttgt ctgagattcg 563581 taacagggaa gttatttagc tggtgacaga ggaaaattga tttgtgaaca gaatcatgaa 563641 ggagacggtg ttttaaagga gttgtctgtt ttgcaggaat taacaaaaaa aaaatacagt 563701 agcttaaaaa caatgtttga tgacaaatat tgtcccacat ttgtctattc aatattagac 563761 caaaccattc cgggagctgt ttatgcagat gatcaaacct ttcctaaatc gttttttata 563821 ggaactgaat caggcattta ttttattgcg ggagaccaag ggaatcggga ttttcatgat 563881 ttcattgcag gatattatga agaacaagtg aaatcatcaa aacgatttac cttgttttct 563941 tccagtgata catgggatag cgtactgaaa cccatactga aagatgactt aaaccaaatg 564001 agaagagctg cattttctta tcaaccaaaa tctttcaaaa agactttgca actgccaaag 564061 gggcttgtat tgaaaagaat tgacgaagac atcatttcac atagcacagc gtttaacagc 564121 gcgtattatg aggagtattg gaattctgtc tcacagtttg cttcaaaagg ttttggattt 564181 gccgtattac atggcaatca cgtagtaagt gagtgtacct ctatattttt agggcataat 564241 cgagcggaaa tggatatcta tacacttgaa gaatatagag gactggggtt agcttattgc 564301 gtagcaaata ggtttatagc gttttgtatg gaaaatggga ttgttcctag ctgggattgt 564361 gatatttgca acaattcgtc cattgcatta gcagctaaac tagggtttaa gacggtaacg 564421 gaatacacta tttactactc tggctaacct taatgaaaga accttaaaag gagataccaa 564481 ccgatgttgg tatctttttt gttttagagt ttttttaccc ttttagcaga aaaatgggtg 564541 atgaaaatct tattcatttt atttactttt aggtaggtaa aacatacccc gccaactgta 564601 accactccgc ctagcagaga gagcagtgtg ggtatctcgc cgatccagag ccaagatatg 564661 atcaaggcta aagccggtgt aacataaagt gaaagggttg cttctgaagc accgacgaat 564721 gaagtgacat atgctagtgc gaagtaagga ataaccgtcg gcaataatcc taagtaaacg 564781 atagacaaag ttgcgcttat tgaagcgttc atcatctctt cgcctaagcc tggcagaaac 564841 acaagcatag gtattgttcc gccccaaatg gtgaatgtaa cgaatggaat aaaaccatat 564901 ttttttatat agcgggcttg aaaaacgaaa taaatactct ccgaaaatgc tgccagcagg 564961 atgaccaaga taccgctcat tgaatatgta aagtctcccg ccccaaatgc aatcaataat 565021 acacccaata aactgatcat agagccaagc catttcgtaa atccaaaatg ctctttataa 565081 aacaggcggg atagcatggc tgagaagatc ggtgccgtag taacgagtaa gcttgcaact 565141 ccggcactaa ctgttttttc accgatgttc agcaaaatgt gatagaatgc aaatcctaaa 565201 aaccctaaaa gaaaaatggc aggaatgtct ttcaagtcgg gtaggcgcat ctgagtcaaa 565261 acagcaaaaa gcaataatgc catagagccg attaacaaac gaaataaagc aaggtgttct 565321 ggcgtgtacc cttcaagtcc tgcgcgaatt cccggaaaag cagatgccca taaaccaatc 565381 atgagactat gagatatcat tatttgaact gttttctttc gcattcctct cactcctctt 565441 tacaaaaacc aaccagttat ttaatgtgtt tctatactaa taaagatttg atgatatggc 565501 ttcaaccagt tcaatagatt ttgacccaac caatttattt taaggagacc gattctatga 565561 gctttccaga agaaaaaaag atgaaaaagc tccctaagta cagacaaatc gttcatttta 565621 ttaaagagaa aataggaaat ggagagtggc cgattggaag caagattcca agccagcgca 565681 cgcttgcaaa agattttcag gtaaatcgga gcacagtgat tacagcgtta gaggaattga 565741 tggccgatgg gctaatagaa ggcacaatgg ggaaaggcac agttgttatc aacaacacat 565801 ggacactgat ggctaagaat tctgctcccg attgggatca atatgtcacc tctggcattc 565861 agatgccaag ccgaaaaatc gttcaagaga taaatcaatc agaatcaaat acagacctta 565921 tacagctcag taaaggtgaa ctttcagctg agatttttcc tttggctgtt atgaaagaga 565981 tgatggggaa ggtatctcaa cacatggagg cattcggata tgaagaacca aaaggttact 566041 tacctttgag ggaggcatta agcaactatt taaaaaccat tggaatcaac gtctcatctt 566101 cttccattct gattgtctca ggagcgttgc aagccttgca gctgatatca atggggctgt 566161 tacaaagagg atcaaccgtt tatcttgatc agccctccta cctttattca ttacacgtat 566221 ttcaatcagc tggtatgaag ctgactggac ttcctatgga taatgaagga cttttgcctg 566281 aaaatgttca tttaacaaga ggagagcggg gaagggctat cttatataca aatccatgtt 566341 ttcacaatcc gactggtatt cttatgtcta aaaagcgacg ggaagaaatc ctagcagtaa 566401 gtgagaatac acagcttcct attattgaag atgacattta tcgtgagtta tggatcgatg 566461 aaattccgcc atatcctatt aaaacaattg ataaaaatgg acacgtactg tacataggaa 566521 gtttatcgaa aacattaagc ccaggtttga ggattggatg gatcgtcgga ccggaaccgg 566581 tgattgaacg tttatctgac attaaaatgc aaacagatta cggatccagt tcgctatccc 566641 agagagtagc ggcagagtgg tttacttccg gccactacca gcagcatgta gaaaaggtta 566701 ggcagcaatt aaaggtgaga agagaattgg ccttgagtgc tttagaaact catttgaaag 566761 aagtggcgac atggaatatc ccaaaaggag ggttttttgt ctggataaaa atattgcctt 566821 ccatatcaat gaaattactt tatactaaag ccttatcaaa agggattctg atcaatctcg 566881 gcagtatcta tgctcaggaa aaagggaatt atattcgctt atcatatgct tatgcatctc 566941 ttgaagacct tcaaaagggg atttatgagt tgggtttaat gattaaagaa ttggcaagca 567001 ggtaactttt atatccttaa atggatgttt cactaaaaaa gagatcaagc ctaatgatcg 567061 cttgatctga taataacaag ggttactaga atagaccaaa tcatggttcg gtcttaaaat 567121 aatcatgtct ctgaacgaaa agtctttccg acttctcttc ctaaaccaaa gtagtgtctg 567181 aaattataga taagcgggct ccatttggaa gggttgatat ggttttcgtc cagaatgata 567241 ctttcctcgg catgaaaatg tagtgcctgc gtctctacaa ttgcgaatga cgattcatat 567301 tctggaagcc gaatgtgttt cacttcggct tcgatttgga tagggcattc tttaattcgt 567361 gttggtgata ctgtttttga ttgtaaaggc gttaaccctg ctgcctcgta tttttctttt 567421 ttatatgtaa atccgatctg cttctttaaa ggcggtatac tcttttttcc gctataagat 567481 gaaattcttt caacgttttc ccataaatcc gggccaggca agtttatgac acactctttg 567541 tgtctttcca aattgtcgat ggcttttcct cccagtccta ctccaaggat tatataatgt 567601 ccaagagccc aagaagaaga cataggacta atattagtgg ttccatcctc attcaatgtg 567661 gttagaagaa atgtcgaggt accataatac atgatcttgg gtttgatttc cttaaatcga 567721 cgagtgtctt gttttttgat gtccaacgtt ttttcctcct tgtcacgctt acatttatat 567781 tgtaaaggat taacatttca actatcatcg aaatatgaat gtaaggagga aaatcatgaa 567841 tcctaatatt gcaaaaatct cttcgttgct atcagatccc tcgcgttctt ccattcttct 567901 cagtctgatg gatggaagga tacaccctgc gggagagctt gcatatctcg ctaacattaa 567961 acctcaaact gcaagttttc acctgaataa attgcttgaa gcaaagctga ttagcgtaga 568021 gaagcatggg agacatcggt attacagatt ggctgactca gatgctgcaa atgtgatcga 568081 acaattgctt catattgcgc ctaaagcaaa agtcaaatct ttaaaagagt caaaagagaa 568141 aaaggacttg catttcgccc ggacctgtta tgatcatttg gcaggttatg tgggcgtgca 568201 aatggcacat tcactagttg agcaggggat gttaaaaaaa gttgatttaa actttgaggt 568261 gacttcagag ggtgctttat tcttttcgaa gttaggcatc aatgaagagc aacaacggaa 568321 taagaggaga gcctttgccc gctgctgttt ggattggagt gaacggcagc atcatattgc 568381 aggagcatta ggaaacgccc tattggtgcg catgttagaa gaagaatgga tcgttcgtat 568441 gcctaaaacg agagcgatta ggattacaca aagcgggaaa atcgcgtttg aaaagcacct 568501 aaacgtgaag atttaggatt ttgaagcgga aacatcagat gatgaggcac gatatctagg 568561 aggagtaaga tttgttctaa tcttactcct tcttcttatt ttgaagcagc tcgattcccc 568621 attgcaatag agatgcggtt ccaactgttt atttgattaa tgatcagaac aaggtcaaca 568681 tattgttcct catcataatg ttcccgcacc cgatgatata gctcatcagg aaccctttta 568741 gatggaatga gcgtgatgtg ttcagatagt tcgagagccg ctttctcttc aggtgagtaa 568801 aaatcacatt cattccaagc atgtaaacag taaattcgct gttcagtttc tcccattttg 568861 cgggcatcgg acgtatgcat atctatgcag aaggcacagc cgttcatttg agagactctg 568921 attttgatta gttctctcgt cgttcggtta attgaggatt gtttcgtgta tttctccata 568981 tccatcatga ttttcatacc ttcaggtgca atctcatagt aggacactct ttgactcata 569041 aagcaagact cctttccata gaatacctag attgtatccc ggtattgatc attttaccaa 569101 tgtgcggttt gaatgacagc tgtttcagcg tcttttggaa agaagcttct ttgaataaaa 569161 ataagggtag ccagcaatga tgagtggagc tgctaatgca agcagtatcc atgagcctga 569221 ttggctgtct ctagtgactc taatgaatat ataagtaccg atcagaaaat ataataaagc 569281 acctagaaac caatacatgt tcattcctct ttttccttgc tttttggttg cgcatttttg 569341 tctgtcatat ggcttaatcg atcagggttc tgatttttta ataccttttc ggtccggatt 569401 ccttttctct ttaatgataa aattgtgaga tcaatcgatt tcaatgatga tcattccttc 569461 aatgaatagt aagttcctta tgattttaaa ggtaaatttg aaaagataaa acgtacatag 569521 aggcagaacg ttcatgtacg tttgggcaat gatcacttgt tggaaactct aatgtttccc 569581 tgcacctgat attgttgtgt tccttctctt cctataaaat gattggatac atgtatgttt 569641 gcacgttgaa atatgggttc gattttcatg aatctctatt cggtgaaaca ggtaaaggaa 569701 gtggataagg tttgcttata aggaatcctt ttaaagataa atattactca catgataggc 569761 gggcattaaa catgcttgca ctcagagtgc cgggcctggc ttttattctc atgatctata 569821 tagcctctat cgtgctgcaa tttgtttctg ggggctggtc cattttattg ctttatgcgt 569881 ttaccatatt aatcgccatt tttgctttgc ttcattggca ctcatatcgc tgggttaaga 569941 aaagagtgat tctgtatttc gcggtacaag gtttgatcac ctttgcactt gctaatctca 570001 tgactggctt ctttatactt gtgattatcg gcctttatgc atttttaatt ggacaaatta 570061 taggaatggc agacagaaga aggacttttc tcattcttta tctattgctg ctgctggtca 570121 taaattcggc gtatcacctt cataaaggtg aagttttgca ttttattgtt attgctgcgc 570181 cgatcatgat tgtcatcatc acttatgccg caacattttt tgcccaagtc gatgaaaaaa 570241 taaaagctca attgactctt gaaaggctgg agctggctca tcagcaggta gaacagctga 570301 cgctgcagaa cgaaagacag cggatggccc gagacttaca cgatacgctt gctcaaggtc 570361 ttgtcagttt aaatatgcag ctggatgcga ttcatgttca tctcgccaaa ggcaacacag 570421 agagagcgaa ggaaatcata caacaatcga tgaaaagagt gaaaagcaca atagctgatg 570481 cacgttcagc tattgacgat ctccgcagca aatcagaaga aatcggtgtt ttaaaagaaa 570541 gaattacctc gctaatggat cattttatag agtcgacagg catggcttgt ttattagatt 570601 acagattgca tcaggtgctg gatgtgcgta cagctgaaaa ctgttattac atcattggag 570661 aatgcatgac gaatgcggca aagcatgctg aggcgaaaac aatctggata tccatttggg 570721 atgatgaaaa gggaaggctc catttaacag ttaaggataa cggcaaggga tttgatgttg 570781 aaaaaggaaa gaaaaagaga ggacattatg ggcttcttgg catacaagaa cgcgtcaggg 570841 caataaatgg ccaattcaat atcaagagta caaaattgaa aggaacacaa attgagatca 570901 ctgtaccaat tcagggagag atgcaagatg aataaggttt taatcgttga tgaccatctt 570961 gtcgtgaggg aaggtctgaa gcttttaatt gaaacgaatg atcaatacac cattatagga 571021 gaggcggaaa atggaaaagt agcagtccgt cttgcagatg aattagaacc ggatatcatt 571081 ctgatggatt tgtatatgcc ggagatgagc gggttagagg ccattaaaca aataaaagaa 571141 aaacacgata cccccatcat tattttgact acatataatg aagatcactt aatgatcgaa 571201 gggattgaat taggagcgaa aggatatctg ttaaaagata cgagttcaga aacccttttt 571261 cacacaatgg atgcagccat cagaggaaat gtgctattgc agcctgatat ccttaaacgt 571321 ctgcaagaaa tccaatttga gcggatgaaa aagcagcgca atgagacgca gctgacagaa 571381 aaggaagtca ttgttctaaa agcaattgct aaaggtctta aaagcaaagc gattgccttt 571441 gatttgggcg tctctgagcg aacagtaaag tccagattaa cgtccattta caataaatta 571501 ggcgcgaatt caagaactga ggcagtaacg attgccatgc aaaaaggtat tctgacaata 571561 gacaactaaa ctgcatattt gaaaattgcc caaacgtaca tgcccgaatg tacgtttttt 571621 tcatttcatt gtcaactaca atgagaaaga atgtgatcaa gcaatgtgtt gaaaggagat 571681 tatcatgtca aaaatgttat atacattagg aggatgggtt gctcgcaatc gcataaaagc 571741 aatatgtgcg tggatcgttg tgttagttgc tgcgataggc cttgcagtga ccttgaaacc 571801 aagtttttct gaggatatgt ccatacctga cacaccttcg gaaaaagcga tggatgtgat 571861 tcaaaaagaa tttcctcatg gtcctgataa agggagcata cgggttattt tcggtgctgg 571921 tgatggggag aaacttactg ggaagccagc aaaaaaagca atagaagata cgttcaaaga 571981 aatcagtaaa gatgattctg ttgactcgat tgcaagtcct tttgtgacag ggacaatcgc 572041 gaaagatggc acagttgcct atgctgatat ccagtataaa tcatcagcag atgatataaa 572101 ggattactct atcaaacact taaaagacag tttgaaaatg gctgatgatg aaggattgca 572161 aactgagcta agcggagatg taccgggagc ggagatggag ataggcggtg tctctgaaat 572221 tgtcggcatt atcttggctt ttgtcgtttt agccattaca ttcggttctt tattaatagc 572281 aggtttgccg attttaactg cactgattgg tttaggtgta agtattggac tggttttgat 572341 tgggacacaa gtatttgata ttgcttctgt cagtctttca ttagccggaa tgattggcct 572401 tgctgttggt attgattatg ctttatttat ttttacgaaa caccgccagt ttttaggcga 572461 aggcatacaa aagaatgaat caattgcgag agccgtggga acagcgggaa gtgcagtggt 572521 ttttgccgga cttactgtta tcgttgcact ttgcggatta actgtcgtta acattccttt 572581 tatgtctgcg atggggctga cagcagggct tagtgtactg atggctgttt tggcttccat 572641 cacacttgtg cctgcggtct tatcgattgc agggaagcgg atgattccga aatcaaacaa 572701 gaaaatagaa aaacaaagca ctgaaacaaa tgtctgggga cgctttgtca ccaaaaatcc 572761 tatcatgcta agtgtatgca gcattctgat tttgatcgtc attagtatcc catctatgca 572821 tttggaactg ggcttgcctg atgctgggat gaaagctaag gataatccgg atcgccgggc 572881 atatgacttg cttgccgaag gctttggaga aggatttaat ggccaattaa caatcgtagc 572941 ggatgccaca aatgctacag aaaataaggc ggaggctttc gcagatgcag tgaaagaaat 573001 aaagggctta gaccatgtag caagtgtcac tcctgcaatg cctaataaag aagggaactt 573061 tgccatcatt acggtcgttc ctgaaacagg tccaaatgat gtcacaacga aagatttggt 573121 acatgatgta cgcagtttat cagataaaaa cggagtagat ttgcttgtta ctggatcaac 573181 tgcagtgaat attgacattt cagatcgcct gaatgatgcg ataccggtgt ttgctgtact 573241 tattgttggc tttgcgtttg tattgctgac catcgttttc cgttcgctgc ttgtgccgct 573301 tgttgctgtt gcaggtttca tgttgacgat gacagccact cttggaatct gtgtatttgt 573361 cttgcaagac gggaatctca tcgacttttt caaaatacct gaaaaagggc cgatactcgc 573421 gttcctgccg attttatcga ttgggattct gttcgggtta gccatggatt atcaagtatt 573481 ccttgtcagc agaatgcgtg aagaatatgt aaaaacaaac aatccagtac aagccattca 573541 ggctggatta aaacacagtg gtcctgttgt tacagcagcc ggcttgatca tgatcttcgt 573601 ttttgcagga tttatctttg caggcgaagc ttctattaaa gccaatgggc tggctctttc 573661 ctttggtgta ctctttgatg cctttattgt aagaatgaca ctgattccaa gtgtcatgaa 573721 gctgatgggg aatgcagcct ggtatttgcc gaaatggtta gacaagatta ttccgaatgt 573781 ggatatagaa gggcatcaac tgacaaagga aatacagccg gaaatagatc atgaacaaaa 573841 gaaacaaatc agtgtgtaat agaaaaagca gatcttttat gatctgctct tttgcttatg 573901 gtagtattta gaagatgaag tcggcagtta aaaggagacg cttatggcgc catcactcat 573961 tttcgatatg gatggaactt tgtttcatat tggcagaagc tgcatcatac tagcaggcat 574021 cccaggagaa gtgacatgat tttttgactt tgcattcact acttgatgcc aaggatcttg 574081 agaatccttc ttgaaaataa aggattttac aactgatcat ataagaaacc taaagaaaca 574141 agcacacaaa accagctgcg ggttttgtcc aagaaaaata gagtccataa gagggactct 574201 attttttgaa gtgcccggct agaagcatat tgcaggactt tatgaatgca aatcactatc 574261 ttataagccc ttaccgtgaa atgcctgttt ctgcattgaa aaaacgcatt acacgttcat 574321 ttacgtaagt gggttgttcc atcgataaaa catgtccggc atttttaatg acttccgcct 574381 caatatctgg aacgaatgaa gaggctcggt gcagggctga gtggggatca tagatgactt 574441 catgttcacc aagtaataat aggataggaa ctcttgctga acgtaattcc tcatcggtaa 574501 aaacatacgg aaatccgtcg gcattaggat ttggatttct tgatccatcc tgccacatta 574561 cccctgcctt aaactgcttc acaaaaatcg ggtgcagcac attctgatca ttcatcatcc 574621 aatttaagaa tgtttcaact ccatttgacg ctgtaaggcc aagagcgtat ttgtagaaat 574681 cgtgatgaaa tggcaaaaac gtttctgccg gactcagtat agctgcgctt tttactctct 574741 caggcatacg taaaaggaaa ttcatcgtat ggagaccgcc aagcgaaagt ccgatcatgt 574801 gggacttttc gatccccaga ttgtcaaaca catcaagaag ccaattggcg taatccgttc 574861 ttgtaccgct tacattctca ggaatactct tgtttttatc acctatgata tcaactgcat 574921 aagttctgta tttactgctc caatcggcga tgttgggata ccacatcgtc gagctgaata 574981 atgctccgtg gagtaataca agcggcgggg catcctctgg gccgcttgca atcacatgtg 575041 tttgaccaaa acgagtagat atatagaatg atttacaacg gaccggccaa agactaaggc 575101 tttcattata agtttgataa tagcggatac cgttgtcact taattcggga atactagatg 575161 aatggtttga catacaaatg cccctcccaa ttttgtttaa atgaatgtgc cgtttcgtga 575221 tggggaatct gattttgata taacagactt tatttacaat ataatacagt tgttattaga 575281 cgtcaaatcc aagatgaaaa ggaaaaaaac gattgaaaca gattattgaa aatcaatata 575341 acagaatatt aacctccttt gtggagccgc ttcattaaaa ccgcaatcca aatgcatgaa 575401 tcacaaaaat cacaacagga gggatcagga gggaaggcag cagattcagt gttttgaact 575461 tcttgattcc aagaatgctt agacctgaac tgaggatgag tatgcctccc acaattgtga 575521 tttcattaat aaggtctgta ttgattgcgc tctccattac ttgtgcaaat aaatagatgg 575581 agccctgcca ggaaaataat acaagtgcgg cagccgctat tccaaaacca aaagttgaag 575641 cgagcacaat ggaggtgatc ccatctaaca tcccgtttgt cagaaggtat gtataatctc 575701 catgcaaagc ggcttcaaca gggcctaata ttgacagcga acctatacaa aataataaga 575761 ccgcagttga taagccctct gctaaattgc ttttagaaaa tttgttcacc agcttgttga 575821 atcgtaattc taaattgatg atctggccta gcaaacctcc aatggctaaa ctcacgatga 575881 atagaatggg gtatttacta tcaggcaaat gctgtgtaat ggcgttgatc cccagtgcga 575941 ccgcagcgaa tcccattgcc tgcatcaaaa tatcctggta ttcatcttta atgccttttt 576001 tgaatatccc cccgattatg cttcctgcaa tgatcatcac tgtgttaaaa atcgttccaa 576061 acataagctt tctcctccaa aaatcattcc tgcataaaaa ataaaccctc tagttagtag 576121 agagtcaagg gagatcaaaa catattcatg agattatttg atgggcagca ggatttcagt 576181 cacgtaatta tctaggttat tcgtaatgcc ataatcaatg agtgtgattt cgattgagtc 576241 ccctgctacc tcataatgat gttctttcat atatgccagt aattttttgt agtatggttc 576301 ggcttctgga tgtgaccctt taaacctaat ttgcagatat tctcttgaag gaaagatgat 576361 ttctgaagaa gttttttcat tttcatcttc aagaatcata aatatactgg aatatttgtc 576421 aaactgtttt gctttcacat ttgctgcaga aatggataaa ccaatcttgc ctatgaatat 576481 atcttcgttt acattcaggt gggttctcaa ttcagctaac gaatgttcga tatcatggcc 576541 gagaacatat tcatgctgca aataggccac acgcattgcg ggaagtttga tttttgaaat 576601 ttgatgtaac ggcatgttaa cggcatcttc tatatgtgtg atgcgtcggg agatctttcg 576661 ttcaatgcgt tccaattctt tcttcttgcg atcaatttca acctgctggc tttttagtaa 576721 atgaagaaga gtgtttgtat tttgagagtt ataaaaatca agaagcttat tgattggcag 576781 gcctagggcc ctcaaatact tgatggtatc cagccgctca aactgttggg tagaataata 576841 tctatagttc gtttgctcat ctttatattc cggtttcaaa aggccgattt catcataata 576901 ccgaagagca gagattttca cattgaataa ctttgacact tctccaatcg aaaaaaattc 576961 cttcattcta acaacctttc tgtcctatga ttgatataca cacattatat agtacggcga 577021 gtactaaagg taaagtttgc agcataaaga aaaaactcct tctaaaaagg agcttttcat 577081 tcttcgaaat aaggatttac atggatgagc acttcttcta catctgaaaa ctgtcttttg 577141 atttcatttc gaatttcgcg ggcaatgtcg tgtccctgct taattgtcaa atcatgatcc 577201 aaagataaac ggacatcaag caatttatag tggccatgtt ctcgcgcgcg gattctatca 577261 attcgtttta cctgatcaca ttgaaaaata acagctttat attcctctat cagctcggga 577321 tcaacactct tttccatgag cacatcaaca gacggcctga ttaattccat tgaaatctta 577381 aaaatgaggt aagcaacgat tgcactggca atggcatcgg cgtacaacag ataggaccat 577441 ccacggctgt ttccgatgat agccaacagg acgccgataa aagcggcaag agaggcaacg 577501 atatcgcctt tatgatcgta cgcaatcgct ataatcgctt tgctgttcca ttttttccct 577561 tgctttatag aataacgata taagatttcc ttagccacgt acgaaatcag agccgcaaac 577621 aatgcgctgt attggggaac gcttggccct ttaacaaagg acagaatcgc ttctatgagg 577681 atataaacgg atacgatcac taagataatt cctacaatcg cctcactaat gacttcagct 577741 tttccgtgac caaaaggatg gtcttgatcg ggcggtttat tggaaattcc gatcactgcc 577801 aagactgcaa tcgaagcaac gacatctgcc gcggaatgta ttccgtctgc aaacacggct 577861 tcactatcgc ctaccagccc aaaaaagacc tttcctgcca ttaagatcag attggcgatc 577921 aatgcaatca aagcaacttt tctgcttatt tgttctcttt cacttgccat tttttcctcc 577981 tataaaactg cacaaaaaaa taggagtgct ctatatacgc tctccgtatc ctttcctgtg 578041 taatcacttt gtttatcata ccaattcaat ttcgagtggg tctatagcaa cgttgtttcc 578101 tgtttactaa taaataaggt gacagaaaaa aagttggagc tatgctaaaa aggtcataca 578161 gcaaacaaat gagttcttat gtaacaacag tgatgattcg ctattaaaat gctgccgtca 578221 gtgaaaaatt tccacctaat tttcaaaaac ctattgacat gagaagatct gtattttact 578281 attatctcat attcaagata ttttaatttg agatatttgg tcggaaagat cagcgatcaa 578341 gcgcaactct aagtgttcaa tcgttgtcag ttcttttaca caatattcaa tatgattttt 578401 tataacataa tatctcgaat tcgagataaa agggagtgta gcgtaatggc tgaatttact 578461 catttagtca atgaaagacg atctgcaagc aattttcttt caggtcatcc aatcacaaaa 578521 gaagatctca atgagatgtt tgaattggtt gcattggcac catcggcttt taatttgcag 578581 catacaaaat atgtgacggt tcttgaccag gacgtaaagg aaaagctgaa gcaggccgca 578641 aacggacaat ataaagtggt tagctcttct gcggttctct tggtattagg ggataagcag 578701 gcatatcaac aagcggccga tatctatgaa ggtttaaagg tattggggat attaaataag 578761 caagagtatg accacatggt gcaagacacc gtttcgtttt atgaaaacag gggagaacaa 578821 tttaagagag atgaggcgat aaggaatgct tcactttctg cgatgatgtt tatgctgagt 578881 gctaaggaaa aaggctggga tacctgcccg atgatcggct ttgatgcgga agccgtaaaa 578941 cggattttga acatagacga ccaatttgag gttgtcatga tgattacgat tggaaaagaa 579001 aaaacagaga gcagaagacc gcgcggctac cggaagcctg tgaatgagtt tgttgagtat 579061 atgtaaaagg agcggataaa aatggctaaa aaaacgatgg gaattcatca tattacagcg 579121 attgtcggtc accctcaaga gaacacagat ttttacgcag gagtgcttgg gcttcgtttg 579181 gtcaagcaaa ctgtcaattt tgatgaccca ggtacgtatc atctttattt tgggaatgaa 579241 ggcgggaagc cgggaacaat cattaccttc tttccgtggg ccggagcccg ccaaggcgtc 579301 attggagacg gtcaagttgg cgtgacttcg tatgtcgtgc cgaaaggggc tatggcattt 579361 tgggaaaaga gactagaaaa gttcaacgtt ccctacacca aaatcgagcg ctttggggaa 579421 caatatgtag aatttgatga tcctcatgga ctgcacttag aaatcgtgga aagagaagaa 579481 ggagaggcta atacgtggac tttcggagaa gtaacgcccg atgttgccat taaaggtttt 579541 gggggtgcaa ccctattatc agagcagcct gacaaaaccg ctgacctttt agaaaacatc 579601 atggggctgg agcgagtcgg caaagaagga gacttcgttc gttatcgttc cgccggtgat 579661 atcggaaatg tgattgacct taagttaacg cctattggcc gcgggcaaat gggggccgga 579721 acggtgcatc acatcgcttg gcgggctaac gatgatgaag atcagttaga ttggcaaaga 579781 tatattgctt cccacggata tggtgtaact cctgttcggg atagaaacta ctttaatgcc 579841 atttacttca gggaacacgg ggaaatcctg tttgaaatcg caactgatcc cccaggcttt 579901 gcacatgatg aaacacagga aacaatgggc gaaaaactga tgctgcctgt gcaatatgaa 579961 ccgcatcgca cacaaattga acaagggctg ctgccgtttg aagtaagaga gttagattga 580021 tttgacacat aaaaaataaa gaaacatata ttcaattgat gattgctgga tggtactgtc 580081 agcaaagaat cagataaaat caaagatgag gagagataca aatggaagat gcaggactgt 580141 tgcttattcg tataatgatt ggtgtggtgt ttttgtttta tggcacacaa aaattattcg 580201 gctggtttgg cggatacggg attaaaggaa ccggacaatg gttcgaatca attggggtga 580261 aaccaggaaa cgttgcggcc gctctatcag gtcttgggga gttagtaagc ggaattctat 580321 ttattttagg cgtattcctc ccgcttggag ctgctatcat aacaatcatc atgttaggtg 580381 ctatcgtaaa agtccatgga gcgaaaggtt ttgcgaatgg cgccggaggt tttgaatata 580441 acctggtgct cattgcagtt tccatagggg ttgcactcat cggttcagga gcttacgctt 580501 tgcattttta atacgaaagt atgtaagaac agttgctgct tgtcagtaac tgttctttta 580561 ttttcacatt ttcggcaagc ttgcaggtac tctgcaaagc aaaaaagcgg atatcataaa 580621 tataaatctg tatagtgaat gatacgtatt gatgagcttg gtcatgaaaa acagacctat 580681 ttgaaggagt aaatggatga aagagatgac aggattacat tcattagttt ctatagaaaa 580741 ctttatcaaa cagcacaaat tcagttttat ttatatatca aggcctggct gtacagtatg 580801 tcacgcagtt ctgccccagc tcagaatagt attggatcag tttccaaaca tcaaattggg 580861 gcatatcaat gctgacgatg tagcagaggt cgccggcaga ttttcagttt tcaccgttcc 580921 tgtgcttctt ttgttcattg atgggactga gtttctaaga gaagcccgtt ttgttcattt 580981 tgaacagctt gaacaaaagc tgaaaagggt ttatcgatta tatgaaggcg aataaaggaa 581041 taaggcaaaa aaagaactca aatgagttct ttttttattc ttcactaggc gaagaagggt 581101 tatcaacctg cccttgatca cttgtatcat tatcacaact tgctgaaata ataattgaat 581161 gagaaggaga gtaatctcct aatgtgaaat tcactccgta atttttgctg ttcgcagtat 581221 ggctgttttg caagttttgt ccgatatctg tattggcgtt ttgtgtcatt ccatttatcg 581281 tgagatttga gatgttgatt tgagatcgca tgcttcaaaa actcctttca ctcagaagta 581341 gctgtcataa aggacgctgg cagtctattt acttctatga tattgcgttt ttatatcatt 581401 gcatcaacat aatggtaaaa ataatagcga gtgaatgatc atcttttgaa gatgatcaac 581461 ctatcagcag aaataaagcc gcctgataaa gaggcggcag atcgttatat gtcatctatg 581521 aatttgatgt atcgtttttc gtttgcctga aggataagat agtcgttttt aatgatgagt 581581 aggagcctat agcagcgtag ccataaaacc agcccataaa tacgccagaa aagaggctgt 581641 gtcgatggct tatgaaaaca gaaatgacaa ggcctgttat taaggcaact gacggtacaa 581701 aagttttggg gattttcaat aatattttga ggatttgggt tatcaatatg atgattggaa 581761 cagctatcac agcatcccaa aagttcgtgt gaataattgg aaaagccata cggcacctca 581821 tgaagtgttt atttcttaat ttttacgcta aaagcttgga aagcagctct tggatcgcat 581881 atgttacatt ttgggcttga ttggcggagc ttgtttggct taaagcattg gattcaaaaa 581941 ccaaacctgt attactccca ccggaaccct ctgttgtttt agacacagag aacgggctga 582001 tggaaactgc aaatccgtta ttaaaaacgc tgttcccgga tatcgaatga atataaactg 582061 ggaatttcat cattcatctc tcctctctgt tatgactgtt tatacaatat ggtgtgtgag 582121 cagcagttgc ttaaacaaaa cggcaaaaac tttcagtaag agacaaaaac ctgcaaaatg 582181 ccacaagcgc cttttgttaa tgcagctttt tagggacgtt ttttttattt tttttgccaa 582241 cttcatcaaa aatattctga ttgccagact gggcttgtcc gtccttattt atgaaatcgg 582301 ggtgaatgag ttttttcaga tccctgactg ttaaaggctt ggcgtcatca gttaattcta 582361 ttcctaattg cccgtttgcc tctaatgtcg caattttgac atcttgtata gccgtaacgc 582421 cgtgaagcct tagctgcatt tcaagctggt cagctgtaag tctcatcttc tttaagtttt 582481 cgatatgaag ctgtccgttt tcaatgacga tttttgcttt tccggttaac atcttttcaa 582541 tggtgttcga tttcatttgg atccattcca taacgatgag tgtgcttgtg aaaattgccg 582601 ctgcaattaa tgttttgaag aggctgtact cgatgattgg ctgaacgata atagttccga 582661 tcgaaatcat gacaaccgtt tgagtcgacg tcatttgtgc gattgatttc cttcctgaaa 582721 ttctcagcaa aatgaccccg gctacaatga gaacaagaga ttcccaagtg aaattcatgc 582781 taccacctga ccaatgatga attagatttg tcatgggatt ggcttttctt ccggccaatc 582841 gcaatttaat atatccgaaa ggcagtcggt tcattctgtc ctgaaccgaa caatattttt 582901 ggtatagatg gatatattaa gccaaacaat gatagcaaca ggagtttttt ggccgaaaca 582961 atctgggaag cggggagcgc cataacatga ttgaacttga agttgtcatt agaacggttg 583021 ccagctttgg cttgctgtta atcgcagaac gaattttagg caaacagaca atctctcaaa 583081 tgacgatttt tgattttatt gcggcgatca cactaggggc gattgctgcc ggattagctt 583141 acaatacttc aataaaaccg cacaatatgg ccatttcgtt tagtattttt gtgctaacca 583201 tttttctaat ttcgtttctg tcgataaaga acaggaagct gaggaaattt tttgccggag 583261 atccaacagt gctgattcaa aacgggaaga tacttgaatc aaatatgagg aaaatgcgtt 583321 acacacttga ttatttaaat cagcaattac gggaaaaaga aatatttaat atcgaagaag 583381 ttctttttgc cattcttgaa acgaatggtc agctgactgt gttaagaaaa ccgcaattcc 583441 ggcatgtgac caaacaggat ttaatgattg cggtaaacca agaacaaagg cttccgatag 583501 aacttattat ggacggagaa atcattgaga ataatttaaa gcagaatcgt ttgacggaat 583561 cctggctttt ggaagaattg cgaaaaagag acataaaggt gaaagagacc gtgtacgcag 583621 tgctgctggg taatggggat atttatgtgg atcaatataa agaccatata tcagtcccta 583681 tggataagga atgaaggaac aatcaatctt aaagcccctt attgaacgca acggtttcaa 583741 cttgtcttgg gtacgaaata tgcagaagcc cgtttaacag ctgaatctgt aacaaatgag 583801 tttcagcggc ttcgggaagc tgaatgattc gctcaatttc tccgtaatac cgttcacgca 583861 gcacttccat ttcggctgga aaaacaggcg tgatcgttcc tttgatcagc agctgggttt 583921 tagacagtaa acggatcgtt aattcttcct catacacacc gggcatttcc acaatgataa 583981 aattatattc ctcatcttga taaaagtcgt aaacaaacgt agaagcttcg gaatcaaaaa 584041 aatgttccgg ggctttatat ttgagcacat ttgtccaaaa gtcactttgt ttatattcat 584101 tcgtaatctc aagccacttt cgaatttttt cgaaatccat atgagattct ccttaaattt 584161 gatttgaaat cggcgcagaa gggtttccga tttggtcttg gtcactaacg tctgaatcaa 584221 tatttccagt gtttaaaagt gaagacgtag gcgaaagatc ccctaaggaa aagtttgctc 584281 caaaatattt gctgttcgca gtatggctgt tgtgcacagt cggaccgaca tctatatttc 584341 cgttttgcgt gacgccgttg atcttaatat ttgcgatatt aatttgatat ggcatagacg 584401 aaaccccttt aatctaaaat tggcggtggt gcaatcggag gagcattaac gttggatgta 584461 tcagagttgc cgatagatgt ctggtcattt acatcaggat cgtttaagaa gttttccatt 584521 acggattctg taggtgatgt atcaccgaaa gaagagttgg tcccttgaga tttttgattg 584581 ttggtagggc tgttataagc agcttcgcct attgtaattg aaccattgcc cgaaatactg 584641 ttgatcttca aataatatag gttgattact gtagacggca tcccatcaca cccttccatc 584701 tttctgtaca gtacattatg cgccgctgca cccaattgtt ccttgcattt acgggcaaaa 584761 ctctatctgg ccccggagtg atgctcaatt atcagtgaat gaaaagccat tgatatagga 584821 atcaatgaat tgattcagtt attcgaaatg catgagacct tttaataaag gaagctggca 584881 aacaggatca gtttgaaata attgacaatg aagctaatgc catgaaataa tactcgtgag 584941 taacattact cgtgggtatt atttttgggg tggtcctagt tgaaaagtaa aggagtagaa 585001 agccgaaaac gattacttaa agctgccgct aatgaatttt cggttcgggg attccatgac 585061 gcgaaggtaa gtgaaattgt gaaaaaagct gggttcacgc agccttcatt ttacctgtac 585121 tttcaaagca aagaagccat ctttgccgag ttaataaccg attttcactc tcgagtcaga 585181 aagctgacag agtcacttct tctggaaaac ggattaaaca cggaggatgt gtcaaaacgg 585241 gtactgctag ctgtagagac tgtttttcaa tttttggatg aggacaagga tttaaccaag 585301 atcggctttt ttctcaaccc ggaagcaaaa caaatgaaaa aagacttggc gatggttttg 585361 aaagagaact tagaagcaga acagcggctt ggctattttc actctgaact ggatatggaa 585421 actgtcgctg agtgtttggt cggcatgatt gaacatttaa ccgaatcatt tttgttaacc 585481 ggaatcaaag atccggcaag cctcgcagca gaggttgtga atcttttaat ttacgggatg 585541 cttccgaaag ggaatgatgt aagatgatat ctattatgat gaaagtcagt ttggcagttt 585601 ttatgcttgc gggaggcatc ataaaggtaa gccgcgttcc ctttcaagtt gagcattggc 585661 ggcattatca atatccatta tggtttctga ctgttactgg cattcttgaa atagccgggg 585721 cacttgctat gacagcggga atttggaatc ggtatgcagc aattggagca ggtgttctgt 585781 ttgtcgttct catggcggga gcaattcatg cgcatatgtt tcgagcaaga caatctgtca 585841 tcatggcgat acaagcgatg atttgtttga ttgtttcaat catgatcatc atggggagtt 585901 acacgtaagc ttttcactaa tgtttaagaa caagcccatt tgcaggaaat ctccttttct 585961 tatcgaataa tagaaagtcc aggaattaac tgaatcagta aaatagagct ccatttctgt 586021 gttattcgtc cggcatcagc tgggcttttt ttataaagga ggaatacagg atggcattca 586081 ctttggaaga catgactgag gaagagttcg aagcctttcg cgggatgtcc gtgcaaaatt 586141 ttgcgaaaca aaacataacg tcaggaactt ggacggaaaa agaggcattt gagaaatcgg 586201 agcaggcata tgagaacatg attccgaatg ggcgagacag cagcaatcat tatttttgga 586261 acatcacaaa tgaccaagga gaaagaatgg gctggctctg gctgtatgct gatccattac 586321 atccgcaaaa ggaagcgttt atctattcct ttggattgta tgaagccttt cgcggaaaag 586381 gacttgctca attggcgctt caaacgcttg atgaaagagc aagagagctt ggtgcggaaa 586441 ggctggctct acatgtattt gcacacaacg agacagccgt ctatctttat cagaagatgg 586501 gctatgccat gaccaatata cgtatgcgga aacagctatg ctgaaaagcc gcttacgtta 586561 cccaaataca acatgcctat ctggaagcgg tggcagggta ctataagtca tcattagaaa 586621 gattaaggtc atgggaggct tgaacatata aagaaaaagg acaacagctg ttgtcctttt 586681 caatgccgct tgaactttct ccctcagtct tttttgtctt gatgatccag ctcttttatt 586741 cgtttcgtaa gctcattgaa agcctgatca agctccttat accctttatc atttggcgtc 586801 ataaaactga gctttcccag cacttcttgt ctttctgtct caagctttaa ccgaagctcc 586861 tcccgctcat ttctttctga aggaacgtcg tttaactgct tttcgatgcc gttgtttgag 586921 atgacgagtt tactgtttgt tgttttttcg agaaagtatc ggtcatgtga aaccgccagc 586981 aatgtgccgc tgtattgtga cagtgtttct tccagctgtt cgcgtgacgg caggtcgaga 587041 tggtttgtcg gctcatctaa aatcagcacg tctttttcct ccagaatata tgccatcagc 587101 ttgatcttta cacgctcacc catactcata tgcttgatcg gttcagtcca ttgggcggct 587161 gtaaaaccta agtgcctcat cagattttga acgtgccccc ttgctttgaa tgtttcattc 587221 tcaaataact cttccggtgt ttgttctaaa ggcaaatcaa acacctcctg cgttaaatag 587281 ccgatgtttg cggacggcga cacccataca cttccttctg ctgtttcctg tcccagaatg 587341 atgttcagta atgtcgtttt tccgctgcca ttggggccta tgatcgcaac cttttcgccg 587401 tgctgaattg taaagtttgc gtttttaaag agagtccttt ctccaaacgc ttttgttaca 587461 ttctgaactt ctaaaaaacg ttttcctgtt ttgtgggttg tatcgattga aaagcggact 587521 gtatattctg gggtaacggg ttccgccttt gctttttcaa gctctttttc aagccgcttc 587581 tgcttggatt ttatctgggc atccgtacgc ttcgctttta cccggtgata ttctttaaac 587641 ccttcctttt tcgtcgattg agcatgggct ttttccgacc aagaagcgag cccattcatt 587701 tgtgcttcaa tccgttcaac cattttttgc tgcttttcat attcacgctg ctgggtgagt 587761 cttttcttct cccggaactt catatacccg gagtaattcc ctttgaattc aatcagcgtc 587821 tgatcctcaa gcgaccatat ttttgttgcg gcttcgtcta aaaaatatcg atcgtgagaa 587881 acgagaatca cagtgccgtt ataatgtttc agctgttgga tgagaaattg caagcttttt 587941 tcatcaaggt ggtttgtcgg ttcatctaac agcagcagat ctgcatcctc tgatagtcct 588001 ttcgccagcc gcgctttcag tttttcaccg ccgcttaact gatgaaaatc acgaagaggc 588061 acatgccatt tctccagtaa cttcttttcg gcaggtgtct gatccgcaaa ggaatacgcc 588121 gcggtttcct gttcaaccaa agccagtttt atatccttcc gaaggatttg accctgtgca 588181 ggggctaagt cattgtgaat gaggtgcagc aacgtagatt tcccagcgcc gtttttgccg 588241 ataatcccaa tgatatctcc ttgctgaaca ctggcgttta catgtttaaa aacagtttga 588301 tcctttactt catagctaac gtttgttaat gttacgatct ctttcatcca tatccctcgc 588361 tttaaaggga gaataaaaaa atcctcccaa atgtgttgga aggattagcc gtgcctgtgc 588421 atgatcaaat aagctatttt ttataaatag cagtgtcgta tatatagaaa atgggcagac 588481 taatcctatt ttttgatttg aaatattgat ttcaaacggt aaaaataaga ttagttaatc 588541 attgtccacc catcatccct tcttgttttg attacaaaca ctatagcata cctttaaatt 588601 caaaagcaaa ggtcattttc atcaaaaaaa ctcctgctct catttttgag gcaggagttt 588661 tgagtcttat tgatgcttcg cttttctcac tttataaatc acaatcagca aaataaacca 588721 aaccggtgtg acaaataagg aaacacgagt atcctgtgcc agtgccagca caaccagaac 588781 aaacgccagg aacgcaagaa tcaggtaatt tgtaaacgga taaagcggaa gcttaaactt 588841 gtttgttttc gctaattcag gtcttgtttt gcggtatttc atatggcaga tgaccgtaat 588901 cccccaaatg tagataaagc atacggttga aatacttgtg atcagggtga atacgccttc 588961 tggcatgatg tagtttaacg taacaccgat taaaatcacg atagctgaaa agaataaagc 589021 atttctaggc actttacgct gagtcagttt cgccattgac tcaggcgcat tgtgatcttt 589081 cgccagggaa tagaccatac ggcttgtact gaatacagcg ctgttgcatg ctgaagcagc 589141 ggatgtcaac acaacaaagt tgataatact tgcagccccg acgatgccaa cagcgacaaa 589201 tacttgtacg aatgggcttt cgctgggatt gatgatatcc caaggataga tgctcataat 589261 cacgagaaga gccccgatat aaaaaagcag cacacggaca ggaatattgt tgatcgcctt 589321 agggattact ttttcagggt tttctgtttc accggccgta agcccgacaa gctcaatgcc 589381 gacaaaagca aacacaacca tctggaacga gaggataaac ccgtgcatgc cattcgggaa 589441 caggcctccg tggctccaga ggtttgtgaa gctggacact cctgagcttg tggaaaagcc 589501 tttgaaaatc atcacaaggc caatgacgat taacgccaaa atggcaatga ctttaatcaa 589561 agcgaaccaa aattctaatt ctccaaaaag cttgactgtc gccagattca taatcagtaa 589621 aataataaga gcgattaagc caggcaccca ttgcggcaca cccgggagcc aatattgagt 589681 gtagagcccg actgctgtca gatcagccat cgcaatggaa atccagcaga accaatatgt 589741 ccagccggtg ataaaagctg ccatatcgcc taggtagtct tgtacaaaat ccacaaaaga 589801 gtgatagttc aagtttgata acagcagttc acccagcgat ctcataatta aaaagcaaat 589861 gatccctgtg atcatataag caaataaaat cgaaggtccg gcaaaatgaa tcgatttgcc 589921 cgagccgaga aataagcctg tcccaatggc tccgccgatg gcgatgagct ggatatgcct 589981 gtttttcaag cctctctgca acgtttgctg atttatattg tctttcgtca tgtcgtctgt 590041 cactttatgt gttcctccat tgaaaattgt ttattgagtc agcaatctat ttttaatgat 590101 tattataaca ctaaaatttc tatctttttt actaaaaaag gattgatgaa aagaatttta 590161 atgtgatttg gactatttcc cgaaaaagcg gctccattta gggagccgct tttttatgct 590221 ttttcagttt ttgtcataaa caggtagagc ccgtaatctg tcggtgcgga tgcgtagcct 590281 gcctgccgca gcattgctgt gatattgccg cggtggtatg tcccgtgatt gacaacgtgg 590341 ggaagcagtt cggaaacagt tgttttcatg attccgcttg agggattttg aatctggagt 590401 ggcttattga gctgttcttt ttgctgtaaa aatagtatat agcgctcgga taacctcaga 590461 aaaaggtctt ccatttcctc tatttcttta gcctctgtct gttctttaag ctgttcagct 590521 aaagccaacg catcgctcaa ggttttgccg gaaaacactt caatccagcc gagatcagaa 590581 agataaacat gagacaatac atgggatatt gacggaaaca cgctttgaat ttcttgatgg 590641 tatatctctt ttggaagctc ttttaatcgg ttgaatattt gttgattggc ccagacgtta 590701 tattcataca atttgaatgc aaaatctgac atgttaaaat tccccctttc gtgtgtatag 590761 ctttcattat acacgaacat gagttcttat gtagagtgct cgaaaataaa atttgttgac 590821 atatatagtt tagaggaata aactaattga cattgaacat aaagtttagc ggggtaaact 590881 ataatgagga ggggaagata ttgaatgaac aaaagctatg tcaggcgata aacctgtttg 590941 tggaagtcct gcttgaaggg acagaatttg tgcatcgtga aatcaatcag gatgtcttca 591001 agcatatctc aagggaacag gcagacctgt tgaaaatttt aaaagtcaag ggcccaacct 591061 ctcccggcag cctggccatg taccaaaatg tacataagag cgcgatctct aacagactga 591121 aaaagctgct cgaaaaggga ttggttcaat gggacgactg tccggaaaaa agtgataggc 591181 gctctaagct tattaacatt acacccagtg gtgaacacat actagaagaa ttagattctg 591241 ccatctttaa cgcgctcaaa ccgttgattg atgatataga tgaggaacac ttacattcta 591301 tcatcgagat attcaccatt ttaaaaagca aatttaaagg aggagattct gccgaatgag 591361 agcaatcatc aaattcaagt gggcaattgc agccatagta ttagcactta ccgtcgtttt 591421 gagtttgttt tctccgaact taacggagct ggccaatcaa aaggggcagg cccagcttcc 591481 cgctgatgct gtttcagaaa gggcaaacgc cattttaaaa caagcgggag aagacaataa 591541 ttcgatcagt gtagtcttta cattagacaa cgctataaag aaagaaacag agaatcagct 591601 ccggataata attgataaaa tcaaaaagat cgacggtgta gaagaggtaa catctcctct 591661 gtcagcggaa aaagaagtca aagaccagtt gatgtcgaaa gacaagaaaa ccgttctcat 591721 gcctgtcacg attacaggtt ctgataaaaa ggcggaaaaa attgcggacg agatttatca 591781 aatcgttcct gatgacttga cggcatatat tacgggagct tcccttatca accaggattt 591841 cgctcacagc tcagaggaag ggcttaagaa aacggaagtg ataacagtct gcctgatcat 591901 cggtttactg ttgatcgtgt tccgatctgt tgtgacgcct tttatcccga ttgtggttgt 591961 cggtttttct tatctgatca gtcaatctat actgggcatc cttgtataca atgttgattt 592021 tcctatctcg acgtttacgc aaaccttctt agttgcgatc ctgttcggca ttggaacaga 592081 ttactgcata ctgcttctta cacggttccg tgaagaattg gcaaacgggc atgataaaaa 592141 agaagcggcg cttatcgctt accgcacagg gggaaaaacc ttatttatca gcggatttgc 592201 ggtattgatc ggattttccg ccttaggatt tgcgaagttt gcgattttcc aatccgcagt 592261 aggggtagca gtcggtgtgg gaattttaat gatcatcctc tacacactgc tgccattatt 592321 tatggtgacg ctgggtgaaa aattattctg gccttctaag aaagtgctgt cacacagtga 592381 taacaaacta tgggcgtttc tcggcagaca ctccgttgcg cgtccgtttc tgttcattgt 592441 catcacggtg gtgattacgc ttccgttcat cttgacctat gatgaccaga tttcattcga 592501 ctcaactgcg gaaatcagca gcgattataa atctataaaa gctctcgagg ccattaagga 592561 tggattcggg gaaggaaaag cgttcccgat caatgttgtc gtaaaaggag acaaagatct 592621 tacaacagct gatacaatcc cctatctagg aaatatcagc aaagcgatcg agaaagttga 592681 tcatgttgac tctgttatga ccattacgca gccgactggt aaaaaaatca aagatttata 592741 tattgataac cagctaggat cggtttcaga cgggctggat aagacggtga aagggattgc 592801 cgatgtccaa agcggattaa cggatataga aaacggactg aatcaaatgg cagggcaaac 592861 cggctcggcc tcaaatggag ggtctggcgg ttcactgggc gatgcggcag atggcttggg 592921 caaaatcaat cagcagctgc agctcgtgag caaacagatt tcccaaaccg gcaataccgc 592981 acagaccgtg cagcagctta cggcaataag cggacagctt ggccagattc aaaccggcct 593041 tgaacaagcg aaccaacagc tctcaggcca gcaggcacaa gccggaacgc tgacagaaag 593101 cctgaaaaag ctgtccgaag gcgtgaaaag cgcaaatgag ggcctgacga aagtctctga 593161 cggtattaca gcttccagtg atatattaga ggacatgagc aaaagtccaa ctgtaagaga 593221 tactggcata ttcattcctg atcaagtaat gaaggacaaa gactttaaga agtcaattga 593281 ccagtattcc tttgcagacg gcaaaggtgt tcaattaagt gtcgttctgg attcaaatcc 593341 gtactcagaa caagctatta cgacaataaa ccaaatcaaa aaagctgtcg caaacgaagt 593401 tgacggcact cctttggaga atgcacagat cgtgtacggc ggggtcacga gtatgaatgc 593461 ggacttaaag gagctatcca caacggactt ctccagaaca atggtgatta tgattatagg 593521 cctgtttatc gtgttaacca ttttgttccg ctcaatgatc atgccgattt atatgatcgc 593581 gtcattgctg ctgacgtact atacgtcgat atccataaca gaattaattt ttgtaaacgg 593641 cttaggaaac gcgggtgtca gctgggcagt gccattcttc agctttgtca tcttgatcgc 593701 gttaggggta gattattcga tcttcttgct ggatcgattt aaggaagagg tgcaccttgg 593761 cattgagcaa ggtgtcgtca ggtcaatgag caaaatggga tctgtcatta ttacagctgc 593821 cattatattg gccggtacgt tcgcggcgat gatgccttca ggtgtcaata cactgatgca 593881 ggtggcaagt gttatcatca tcgggctctt gctttacggc cttgtcatac ttccgctctt 593941 catcccggca atcattgcga cctttggaga aggaaactgg tggccgttcg gcaggaagaa 594001 aggaaaagag taatcgagag aagagtgatg aatggtcatc actctttttt catgactaaa 594061 cgactaactt cagacgtgtt acccaaaaag atcagacgat caaacggcgg ctgtacttaa 594121 aaacaaagag cccggaaaac attcccgggc tctttgtttt atttccattc tgcaattgta 594181 tcaatcggca gacggtagga agcatagcct tcgtctgctg cttttccgat agaaagtagc 594241 ataaccggta cataacgttc tttatctaat ccgaaggttt ccgcgatgtt ttctttatcg 594301 tatccgccga tcgggtttgt atcgtagcca tgcgcgcgtg cagtcagcat cagctgcatg 594361 gaaacaagac ctccgtcaat caggatcgtt tcacggttga cctgtgccgg aagcttttca 594421 aaatgtgcgg tcagcgcggc gatttgtctg tctttgacct cctgcggcat gtaaccaagt 594481 tccacggctt ttgaatagat ttcttctaga tagtctgcgt tgttcatgtc tgcaaataca 594541 gcgatgacag cagatgatgt tgtgacttgt gtttggttaa agcttgcaag cggtgcgagc 594601 ttttcttttc cttccgggct gtcaatgaca agaaaacgcc atggctgcgc gttaacagaa 594661 gatggggcag ttgttgcttc ctctaagatc tctgtcattt cttctttgct gatttttact 594721 gccggatcat agttgcggat agaacggcgg cctttcataa tttccataaa atcgtttgtt 594781 ttgatcatgt tgatacactc ctcttaagct tcgatattat ttatattgtt tcgcatgcgc 594841 gccagcacat caatgagcag gcggcgttct tctgcgctta catttgcgag catttccttc 594901 atgaaacgct ccttttcctt cttagaagac tcaattcgct ctcttccttg gtctgttaac 594961 cgaacaaggg tgatgcggtt gtcctcaggc ttgcgccgcc ttgataccat gcctttggat 595021 tccagctgtt tcaggtgtct ggtaacggct gcgctatcga tatttacttt cttttgaagg 595081 tcgctttgac tgatctcatc tgcatgataa agcaatgtca gcaattccaa acgagattgg 595141 ctgatgcccg tgcatgcctc gaacttcacg ccaatcacct tgttcacgcc ttgcagctga 595201 tataaaatct cggcttcctc tgaacaaaat gacgccaaaa cccatccctt ctttcctgtc 595261 aaaactatta attgatatat caatgattga cacgtcaatt aatatacaac gattgatttc 595321 atcttgcaag ccatttgcac ttttgaacaa cctcccagcg cataaaattc gctaggctag 595381 aacttagcaa aaaaagctgg ccgcttcttc agatgatgct ggtcacgatg attccctgca 595441 tcattcccat ttataggtgt tcggaatatc actttgccgg cccgtgctca agcggctttc 595501 acaggctgaa agttatgata caatatacaa atgtttcaca gcttcaatcc atagttggag 595561 ctgacatcca ttatataagg gactaggttg aagggaaggt ttgataacat gctgcacaat 595621 ccaactggaa aagaacgctt ggcactagcg tttctgctcg gcatgcttgc tatattgggc 595681 ccgcttaata tagatatgta tttgccaagt tttcctgaaa tcgcgaaaga tttatcagca 595741 agtgcttcac ttgttcagtt aagtttaaca gcctgtctgg tcgggcttac gatcggccag 595801 ctgattgtcg ggccggtcag cgatgcgcag ggaagacgaa aaccgctatt aatctgtatt 595861 tttttatttg cgttatcttc tctgttttgt gcactgtcgc ccaatataac aactttagtg 595921 gctgcgcgtt ttttacaagg cttcactgct tctgcagggc ttgtgctgtc tcgcgcaatc 595981 gtccgcgatg tgtttaccgg aagagagctt tctaaatttt tctcgctgtt aatggtcatt 596041 accgcggtgg cgccaatggt tgcgcctatg acaggcggtg ccattttgct tttgccgttc 596101 gcaacgtggc atacaatttt tcacgtctta atgatcatcg gatttttact agttcttctg 596161 attgcattga ggttaaaaga aacgcttccg ctggaaaaac ggattccaag ctcaatcgga 596221 acatccgtca aaacgatggg cagcctgctg aaggatcgat cctttatggg gtacgcgtta 596281 actgtcggat ttattcacgg gggaagcttt gcatatgtgt ctggtacgcc ttttgtatac 596341 caggatatct acggggtgtc tccgcaggta tttagtattc tttttggcat taacgggctg 596401 gcgattatat cgggcagctt tatcatcgga cgctttggcg gaatcattca tgaaaaaagc 596461 ctgcttcgta tagcggtcat tacggctatg attgcgacgg ctgtgctatt aaccatgacc 596521 atgattcacg gtcctcttgc tacattagtc atatccattt tcatttacat gattacgatc 596581 ggcatggttc tgaccagcac gtttacccta gccatggaaa agcaggggca ccgcgccgga 596641 agtgcaagtg cgctgcttgg aatgcttccg ctgctcctcg gttcaatcgt gtcaccgctt 596701 gtaggcatta atgagacaac agccgttccg atgggagcca tcatgtttgt gacagctgtc 596761 atcggctcac tggcgttttt tggattaacg aaagaacgag tagggcagaa ttcataaaaa 596821 aacctgacat gacgtcaggt tttttgtttt atttagaata acaacagcag gcctgcaatc 596881 gccggagtca aaaagatggc tgatttcaaa accacctttg gcatgaggtt ggtgaatttc 596941 gcgcctacat aggccccgca cattgtcccg accagaactt tgacaagtaa aacgtaatca 597001 acaaaacctt ctgtaatata tccgatgcct ccacctacag ccagagggat gatcacaagc 597061 atcgtcgttc cgacagaatg gcgaatggac agattcagca taatcattaa accgatttga 597121 ataaaaggtg ccgacccgat gccgaatgtg ccggaaagaa cgccggctgc aattcctaag 597181 atgaccgctc tcgtatacgt tgaaagagtg ctttgattca cttgagcctt ctcttttaaa 597241 ataaataatc tgattaaaat gagaattgct gataaaaata acattccagc cgtcaaataa 597301 tgaagcaaat cagccggaat aaaagaagtc agcttggcgc cgaaaaatga gccaaccgca 597361 gcaaagcctc cgactattaa gccgattttc atttgaatgt taccctcgcg atagtggctg 597421 tatgcccctg ataagcttgt aaaagccatg ccggcaagcg aagtgcctaa agccgtatga 597481 atcgggatat ggaaaagaag cgttaaaagg gcaatgacaa agccggctcc accggcgcca 597541 ataaagccta aaataattcc tagaagaaac ataacaagaa taatgagcat attttttcct 597601 ccattgaaaa gatgtaaaaa tgtaatcgtg cgctattctg gcggaggtat ggtgtcctat 597661 tgacgaagaa aaacacgccg ttttttcagt tgccagtagt ccgtcgaccg tcgttcagca 597721 aacatatcgt acctcaaatt cagggatctg acaaggcagt ttgttgcttc ccattaccat 597781 ctgttatatg attttgatga agaaaagccc ttgaatatat tcaaaagagg tattatatat 597841 ggacgatttt aaattagata agccgactcc ctactacctg caattttata accagctaaa 597901 aaaaatgatc ttcaacggga cttttaagcc tggggaacgg ataaacgaaa cacagctggc 597961 gaaaagcttt ggcgtcagcc gctctccgat aagggaagcc atgcgattgc ttgagaaaga 598021 tggtttgtta aaagcggatg accgaaatgg gttttcgatc acgtcgttaa cggcaaaaga 598081 tgtagatgag atttataaaa tcagaattcc gctggagcag ctggcagtcg aattagtcat 598141 agacgaagcg gacgaagaag agctgaccat actcgaaaaa cagcttgaag aaacagagaa 598201 agcgattcac aacggcacgg aagatacaga aatcattcgt ttaaaccaaa aatttcatga 598261 gctgctggtt gatttcagcc ataacagaca tttgaaaaat ttgcttgagc atgtaaatga 598321 cctgattcat ttttgcagaa tccttaatta taccggcgac caccgcgcag aaacgatact 598381 gcgtgagcac cgcaggatat ttgaagaagt gaaaaagaaa aacaaagaag cagccaaaca 598441 acatgtgctg gctcatttca atcatgactg tgagcatttg aagcatgtgc ttgaagaagg 598501 taaagagaat tgatttgtat gatccggtac caagggagag cagaaccctt ggtatttttt 598561 tatgtattca ccacatatct aagaggcccc gttaataaga ttttatgatg gtttgactaa 598621 cgaataatgg gggttaaata tgtttatcca tatcgtcggg cctggtgatt ctttgttttc 598681 gataggcaga agatacggtg cttctgttga tcaaatacgg ggtgtgaatg gtttagatga 598741 aacgaatatc gtgccggggc aggctctgct tatccctctt tatgtatata cagtccagcc 598801 gagagatacg cttaccgcca ttgcagctaa agcgtttgtg ccattagagc gactgcgagc 598861 ggccaatccg ggcatcagcc caaatgcttt acaagcggga gcaaaaataa cgattccttc 598921 gatctcaaat tacattgcgg gaacgttaag tttttatgtg ctccgaaacc cagacctcga 598981 tcgggaatta atcaatgatt atgcgccata ctcgtcttcg atttcaattt tcgaatacca 599041 tattgcaccg aacggcgaca ttgcaaacca attgaatgat gcggccgcta ttgagacaac 599101 ttggcaaaga cgagtcacgc cgctggcaac aataacgaac cttacatcag gaggcttcag 599161 tacggagatt gttcaccaag tgctaaacaa tccgacagcg agaaccaatc tggtcaacaa 599221 catttatgac ttagtttcca caaggggata tggcggtgtc acaatcgatt ttgagcaggt 599281 gagcgccgcg gatcgcgatc ttttcactgg atttttacgc cagctgagag atcgacttca 599341 ggcgggaggg tatgtgctga cgatagctgt tcctgcaaaa acaagtgata atatcccatg 599401 gctgaggggc tacgattacg gggggatagg agcggttgtc aattatatgt ttatcatggc 599461 ttatgattgg catcatgcgg gaagtgagcc gggtcctgta gcgccgatta ctgaaataag 599521 gagaaccatt gagtttacga ttgcgcaggt gccgagcaga aaaatcatta tcggagtccc 599581 gctctacggg tacgactgga tcatcccgta ccagccgggc acagttgctt cagcgatttc 599641 aaatcaaaac gcaatcgaaa gagcgatgag gtaccaagcc ccgatacaat attcagccga 599701 atatcaatca ccgtttttcc ggtacagtga tcagcagggg cggacgcatg aggtatggtt 599761 tgaggatgtc agaagcatga gccggaagat gcagatcgtc cgtgaataca gattgcaggc 599821 tattggcgct tggcagttaa cgctgggctt tacgccgggc ccatggcttc tgcggaaatt 599881 ttttacgatc agaaaagtgt aaaaaaagac accagagctt gggtgtcttt tttttgatta 599941 agtccagagc agcagaatag ttcattcatt tgtaccttgc atgggttgtg ttcccatttt 600001 acgattagta gtagtctgat caaacaaaga gtcagaatac gatttgagag ggagttgtct 600061 acatgaagac agtattgatt ttgaattttc ctgcggaagg ccatgtgaat cctactttag 600121 gcattacgaa agcgttttcc gataagggat atgatgtcca ttatatatcc actgaaaaat 600181 ataaaaaacg attagaagca gcgggagcaa cggtccatct tcaccgggat ctgctgcgaa 600241 cgacacctat tcatgtcggt tcgcccaatg gcattcttga tttcgtgaaa atccatatca 600301 aaacgtcatt ggacatttta cagattgtca aagacttatc taagagcatt caatttgatt 600361 ttgtttatta tgataaattc ggcgcggggg aattggtgag ggattactta gatattccag 600421 gggtctcttc atcggcgtct ttcctgtttg gcgaggagca tctgaaaatc ctgccgctgc 600481 atccggagtc tggagcgccg cttgaattgg atcaagagtg cgaagacctt ttggcaaaaa 600541 tgaaagaaac gtacggtgtt gccccgaaaa acctggttca attcatgaac aataaagggg 600601 aattgaacgt agtgtataca agccgttatt ttcagccaga aagtgatcgt ttcggggatg 600661 aatgtctatt tatcgggccg agctttccaa agagagcgga aaaaacagat ttcccgattg 600721 aacagctaaa agatgagaag gtcatttata tttcaatggg gactgtactg gatcatacag 600781 aggatttctt caacctttgt attgatgcat tttcaggctt taacggaaaa gtcgtcatcg 600841 ctgccggaga aaaagcggac ctgaccaaat taaagcaggc gccggaaaac tttatcattg 600901 ctccgtatgt ccctcagctg gaagtgctgg agcaatcgga tgttttcatt acacacggcg 600961 gaatgaacag cgtaaacgaa ggcattcatt tcagcgtgcc actggttgtc atgcctcatg 601021 acaaggatca gccgatggtg gcgcagcgtc tctctgaact ccatgcaggc tatgtcatct 601081 ctaaagatga agtcaatgcc caaatattaa aacaggccgt agatgaggtt ttgcgcaacg 601141 atcagtatac ggcaggcatt aaaaaaatca atcaaagctt caaagaatgt atggacatgg 601201 aagaagtgat ggagcggatt gatgagttga ttcgccaaaa aaacaaataa gaaaaagaac 601261 tcccgtacct tgtacgggag ttcttgattt aaaacttgat tttgattttt tgagcatcac 601321 tgattttctt atggttatgg tcaaagacgt cacttgtcgt gatttcgatc cacttgatct 601381 cttttgtttt cttctcagca tccgcggcct tatcatgagc atggccgctt gatgcgttca 601441 caataaagcc gagatttccg gacttttcgg cgccgccttc caattcgccg tttaactctt 601501 caagataaat atctttgttc caatcaaagg tttcacccgt atttgttttc atcaatgcaa 601561 tcggcgcaac atttactttt tttgtagagg tgttcttgat atcaacgaaa accttaacga 601621 aatcaaactc ttcatcgtgt gttaactcat gaaagtaatc aatcatgctg tagtccgggc 601681 gcaagtggat cagcttcatt tcttttactg ttaactccac gtcgccaatt ttataggttt 601741 tgttcacttg tttgatatct tttaagacag cttttccttt atcatctgaa aacgtttggc 601801 cgaccttatg caatgtccgg tcatcagtta cctgggaatt aggctgataa tcatctgtgc 601861 tgtccttctg ggatgaagtg ctttgcggct cagcttttac tgttttctcc ccgcctgcat 601921 gctgtttttc agtactggcg tttgatgagc agcccgcaag catgatagca aaaacgagaa 601981 ttgaaagaat tcttctcatg atgattcctc cattaaaaag agatcccgtt acttcataca 602041 agcaacggga caccttgtat tcttttactt atcgttaatc ttaatgttgt attgtaaagc 602101 cttgaaaaca tttttggcga tttctgtatt gtcgatttgg ccggcaaatg tctcactaga 602161 cggaccgtat gcatagacgg gaacatcttc accggtatgt ccgcctgttg tccatccagt 602221 gtgagagcgt ttattaaaga tgttctcgat tgcgttatcg atatccagta cttccttcga 602281 ttttgccgct tcttcaacag attgaatttc ggcttttgtt aaagccaatt tcttttgatc 602341 gatatatgtt ttcaacgttt tttcaacatc cgcgccgtca gcgatctttt ctgccataaa 602401 gtctggtgtg cgctttgcgg ctttaatggg ttcactgaac cagttgtaga tgccgtccgc 602461 accgatggaa tatccgccgg ttgagtggtc agccgttgcg acaaccaatg tgtgcttgtc 602521 ttttttagcg aaatcaatag ccgccttata agcttgttcg aagtcttcca tctcgctcat 602581 ggcgccaacg atatcattgt catggcccgc ccagtcaatc tggctgcctt ccaccatgag 602641 gaagaatccg tctttatcct tgtttaattt tttaatggct gtgtttgtca tatctttaag 602701 tgatggaata tccttcgtac ggtcaatctt tttaggcagg ccgccgtcag cgaataggcc 602761 gagaacttgg ctgtctttgt ttttcagcat gtccttgcga tcatccacgt agctgtaccc 602821 cgcctttttg aattccttaa tcaaattacg gtccttacgg tcaaaattgc tctttcctcc 602881 gcctagaagg acatcaattt tgtgcttgcc gttgaccatc tcatcaaaat aatcatccgc 602941 aattgagttc atattttttc ggctgtggtc gtgtgaacca aaagaggccg gagtggcgtg 603001 tgtaatttct gaagtggcca caagtcctgt tgcttttcct ttttctttcg cagcttcaag 603061 caccgttttg gcttctgacc cgtcgttatc aacggctatg gcattattgt atgttttaat 603121 tcccgcagac atagccgttg ccgccgctgc agaatccgtt acattttgtt caggatcatc 603181 ggggtaagtt gtttgctggc cgacaagata ctgatcaaaa gccgtaggct ccacaacttt 603241 tgtcttttta ttatccttta agtatcgata agcagacgta taagacacac ccataccatc 603301 accaatcaga acaataacat ttttaatttc gtcttggttc ccctttttct tttcctgggc 603361 gctggcttca ggcacactgc cgctggctaa gctgctgaac gcaattgatg ataaaaccgc 603421 gataggcagt aatttcttcg ggaatttttt caactggata acctcctaaa tatagatgaa 603481 tctcaatgac aacccaatta tatttttaaa ctgttaagct agtattaatc gattttaaag 603541 attggattta caagaataat gaactggcac ccttaaataa tggttattct tttatgagaa 603601 gttttagaag gaaagagcga tagtactaaa gaaataaatt ggaggaatag atactggccg 603661 tggataggcg gactgaaatc tgctatagtc gcatagaagc aacccgctta catcttgaac 603721 aatttaaagt attacgttgg aaagaggtat tgtgtaagca catgtctgag cagttcatat 603781 ggagtggcat cattttattt taggagggaa caacatggac gttttttctg agtacttagc 603841 ggggattgct gacccgttcc accgagaaag aacggaagag gtgttaactt ggataaaaaa 603901 taaatatcca aatttacata cagaaataaa atggaatcag ccgatgttta cggatcacgg 603961 tacatttatt attggcttta gtgtttctaa aaagcattta gctgtcgctc ctgaaaaagt 604021 aacgatagcg cacgtagagg atgatattgt gaaggccgga tatgattaca ccgagcagct 604081 gatacgtatc ccttggaacg gtccagttga ttatacgcta cttgagaaaa tgattgagtt 604141 taatattctg gacaaggcgg actgctccac tttttggcgg aaatgaagaa aaaggcataa 604201 catatgagct gtataaaata tgttacgcct tttcatttgt ctatttttcg ttttgatcat 604261 ctattgctgc ttttcatcaa acaaggtctt ttcattgagc gtaagctgac tcgcagaata 604321 atgattacct tgtttccatt tcacttcaat cgtaatatca tggccttcaa gctcatgttc 604381 atctaaccgc tctaaaaaag aaacggactt ttcttttgcg cttccatcag aaaaagtgcc 604441 tccagcataa tcatgcatcg ggatttccgt gtcagaactc agcagaactt catcatcctt 604501 ttttacaatc agtgattcca gataagtgtt gtctatttca attgtatcac cgatccaata 604561 aagtttgccg ctgtattcat tcggtgcatc ttcatttttt gtgaaaacag cttcccaatt 604621 ctgatctttg ctttctccct gccaatttgg atactccaaa cgaacatgat gaatcaggtg 604681 ataggaaaaa aagatcaagc agaaagcgat taataggaat gccgtgaaaa tgagagggta 604741 tttataatga ctggacataa aagactccta ttcgtttaat caattacctt cgaaaataga 604801 atttcatccc gaatcaaaat gccgttttca gccacctcgg gaatctccgg cttgagtcgg 604861 cgcgcttttt caactgcgtt cggaaacact gcggcgaatt gatagcctct cttttgataa 604921 aacgctatcg catttacatt atcattcgtt gtgataagct ttattcgttg acaatgtgca 604981 tgtttagcct tctcttcaac ctgctgaagt aaagctgtgc cgattccttt attttcaatc 605041 atactatcta atgaaataat ttcacaatct ttcccatcta ttgtgtatgt aatacagcca 605101 atgatttcgc cgctttcatt tactgcggca aatccatcta attcatcaca ccgaaaaatg 605161 ccgctggaaa tcgccatctc gggtgtaccc caatgcttgg caaaaaaatc ggtcaacata 605221 tgtttcgcta tctcattgtt tgggatgatg atcatcataa cactcctcta ttgaaagatt 605281 gcatatgtac tatcaatata aacaatatat aacaaaaaaa atagatgttg aggtgacggc 605341 atggaaatca gcgatatcat ttacgggcag caccatatag acggagtgct ggaagagctt 605401 atcaaaagcg ctcctgtgca aagattaaaa ggaatctatc aaggcggagc aagcttttta 605461 gtcaatcgaa agtggaatgt gaccaggtat gagcactcca tcggcgtgat gctcctcatc 605521 aaaaagctcg gaggaacgat agaagaacag attgcgggtc tgctccacga cgtatcacac 605581 acagcttttt ctcatgtggt cgacgttgtc tttgaaaatc aagcagaaga ctatcatgaa 605641 aacatctttc aacaagtcat tgttcactct gaaatcccgg acattttaca aaaacacggc 605701 tatcatactg aagaactttt atctgacgat tcaaggtgga cattgctcga acagcccgca 605761 ccggagctgt gtgctgatcg gacagactat acgctgcgtg atatgtaccg atatggacac 605821 attaacctgc acgaagcgca aacctttttg gatcatctta ttgtgagaaa cggaaggatg 605881 tttcctgata gtattgaagc cgccgaatgg tttgtcagtg tgtactacaa ggaagtaatt 605941 gatttctttt tgaatcctgt gaatgtatat ggatatgaat atttagcgcg agcattgaag 606001 gcagcgctgc ggcatgatgt catatctgca gaggatctgc tgaaaacgga ccaagaggta 606061 ctgaacatcc tgcgtgcatc aaaaaatgaa gaagtcctga gcttgcttac atccattcat 606121 cccggcatac aagtaataga ggatgacatc cagtacgatt tccatcaaaa gaagaaaatg 606181 cgcctaatcg atccatccat ttttcttgat gacaaatgga tcaaatcctc aggtgtttct 606241 gaaaaggtga ggaaaatggg tgaggccgct tatcaaaaag caaaaaaagg tgtgtatata 606301 aaaatcttaa agcagtaatt gccgcctgac agcggctttt tttatgtttg gctttgcaaa 606361 caaaggggaa taggacaaac tgcgggaacg ctttatgaga atatcagcgt atttacatac 606421 cgttcggggg tatagtatta tcgagagggc atgttttcat tgtctgcggg caaaagttac 606481 aggaaaaaaa tgaagcaaag gagaatgaac atgaaaatct ctaaatatgc actgggaatt 606541 ctgatgttat ctctagtttt tgttttatca gcatgcggca ataacaacag tacgaaagaa 606601 agcacacatg acaatcattc agactcctca acacatgaag agatggacca ttccggatca 606661 gctgacgttc cagagggatt acaggaatct aaaaatccga aatacaaagt aggcagccaa 606721 gtaatcatca atacttctca tatgaaaggc atgaaaggtg ctgaagctac ggtaacaggc 606781 gcctatgata caacggcgta tgttgtttct tatactccga ctaatggggg acagcgtgtg 606841 gatcatcaca aatgggtgat ccaagaagaa atcaaagatg ccggagataa aacgttacaa 606901 cccggagatc aggtgatttt agaggcttct catatgaaag gcatgaaagg agcaacagcc 606961 gagatcgatt ccgcggaaaa aacaactgta tacatggttg actacacatc gacaacgagc 607021 ggcgaaaaag tgaaaaacca caaatgggtc acagaagatg agctttcagc taaataataa 607081 aaaatcctcc ttttacaagg aggatttttt tgctgtttga acaggtcttg ttaaagaaat 607141 gaaagcaaac aggacagcga tgatcacaat cgatccgccg caccatgccg ttgacaccac 607201 agtacccgtc tgatccaaaa caacaccgcc aatggctgag ccaagggcaa ttccgacttg 607261 gagggccgat gtgttaaagc tttgctgaat gtcagacgaa tcaggtgcaa tttcaattaa 607321 atagctttgc tgagccgggg cgaggctcca gctcagaaga ccccaaatca ccatgacagg 607381 caaaaagaaa atcatagacg atgtagacag cggcagtaag aacataatga tggcaaagga 607441 accggtcacc agcaaaatgc tcttaaagga accaagccgg tcagatagcg ctcctccgaa 607501 agggcctccg catacagcag atatcccgaa aaggaaataa caaatgctga cccagaaaga 607561 gctcaggtga agagtctctt ctaaaaacgg cgcaaagtaa gcgtaaagcg tgtagtggcc 607621 agctaatgta aacatcgtga cgaggtgtga actcgcgatt ttcagattac cgatcgtctt 607681 gagttgttcc cggaaaggaa tcattttctc cgccggtatt ctttcaaaga agattgaaat 607741 aatcagcatg gagatcagtg ccaacaggcc gatgccaagg aacaaaatcc gccacccgaa 607801 ggaatcgctg attaagattc cgagcggcac gcctaatgcg atagcagagc tgaatcccat 607861 aaaaataatt ccgattgcgc gggctctgta ttcaggcgct acaattttcg gggcaattgt 607921 taaagaaagc acaacaatca gccctgtact cattgctgcc aataccctag ataccatcag 607981 tgttgcgaaa ttagggctga aataggcgac aagattgcta aggaagaaaa caaataaagc 608041 aattagatat aagcgcttcc gctcaatctt cgcagtcaat gccaaaagca gcggcccaga 608101 tactgcatat cccagcgcaa acacactgat cagctgtccg gctgaaacaa tggaaatgtc 608161 taaatcattt gcgatctgag gaagaattcc ccccacaatt aactcaacca atccgactgc 608221 aatcgtagaa gctgcaagca ggaaaacttt gaaattcata acaaactcct ttacttaaat 608281 gttttgataa ataaaaaaaa tcctgattac aaaaaatgtc ataaacaaat tttgtaatca 608341 ggattttacg gttcctggta gacaccctca aaccatatta ttgaggttat acaagtgata 608401 atagctattt aattgattcg tttccgttga tgagtgtacc acattatgaa tgaatcttcc 608461 atagaaaaat ttataaaacg gtgaaccgga aaaaaatatg attatattta ttttataaaa 608521 gtatagacat ttaaaattaa atgactataa taatcaatgt aagcgtttta ataacagggg 608581 ggatagcagt tgaaaaaaat attactcgcg tgcagttcag gaatgtctac cagtttattg 608641 gtgacaaaaa tgaaggaata cgcacagtct atcggtgagg aagcggagat ttgggctgtt 608701 ggccaggata aagcaaaaga agacatgaga aaagcggatg ccgttttgat cggtccgcaa 608761 atgagctttc tgaaaagcga gctccaaaaa gaagcagatc aatacaacat tcaagttgaa 608821 gtcattgaca tgatggccta cggaatggca gatgggaaaa aagcgtatga gcaggcattg 608881 tccttaatgg tgaatcaata atggaacaga tgaaaatcac gaatttaaca gacgagcaaa 608941 tcagttttca gctaatcctg cacagcggaa atgcccgcag ctgcatcata caatcactgc 609001 gcgcctataa agaagggaaa aaggacgagg ctgatgccct cattgccaag gcggagcagg 609061 atttatccgc ggcccatgac attcactttc aaatgataca gaaggaatcc ggcggagaag 609121 caacagcttt ttcattgctg cttatgcatg cagaggatca tctgatgtca acattatcca 609181 tgaaagaatt agtgaaagag atgcttgatc tctttaaaac caagaatata taaaaaatcg 609241 gggtggatag ggtgttcgag aaaatcagcc aattccttgt tccaattgca gggaggttaa 609301 acaataaccg ctatttgcaa gtgttgcgtg atgcatttat gctggctttc ccgctgacga 609361 tattcgggtc catttttgtc gtgttaacga atttgccgtt tctaaacaaa atcatgaacg 609421 cctcaatgct tacgtcgttt cagtctcatt tcggcattgc ctccacggcg acaatgggca 609481 ttatgtctgt ctttgttgtg ttcgggatag gctattacct gtcgaaaagc tatcaggtcg 609541 aagctgtatt tggcggagcg atcgctttgg tttccttttt gctcttaacg ccatttatca 609601 ttcagccgga aacaggtgat gccattacag gggttatccc ggtcgatcgt ctcggtgcaa 609661 aagggatgtt tcttgggatg attacggcat ttctttctgg cgaaatttac agaagaatcg 609721 ttcaaaaaaa cctgacaatc aaaatgccag ccggcgttcc gcctgctgta gcaaaatcat 609781 tcgccgcact tattccggct tttatcacat tgactgtatt tttgctgatt aacgtaatgg 609841 tgactctgtt ttttaaaaca aatatgcacg acgtcattta tcatgcgatt caggctccgc 609901 ttgtcggact tggaagcggt atcattccaa cactgattgc cgtgtttttc attcaaattc 609961 tttggttttt cggactgcat ggacagatca ttatcaactc cgtgatggac ccgatttgga 610021 atacactgca ggtagaaaac ctttctgctt acacggcggg aaaagaaatc cctcatatta 610081 tttcaaaacc gtttatggag atttatacag tagggatggg cggaacaggg atgacgcttg 610141 cgattgtgtt taccattctc atattcatga aaagcaggca gatgaagcaa gtatcaaaac 610201 ttggcctcgc tcccggtatt tttaacgtaa acgaaccgat tatctttggg cttccgattg 610261 tcatgaatcc gatcattatt gtgccttggg tgctggcacc gatggttgtt acgctcgtca 610321 cctatctggc tatgtcagcc gggctcgttc cgcctccaac tggtgtgaca gtgccgtgga 610381 cggttccatt attcattaat ggcatcatgg cgacgaactc aatcatgggg ggcgtgatgc 610441 agcttatcaa tctgctgatt gtcttcgtga tctggtttcc gttcctaaaa gcaatggata 610501 aattaaatct ggcaaaagaa aaagaacagg ctgtgcagga gacagctgct cagcaaaatg 610561 ataacagcat aaaaatgtga cataagggga gagagacttg gcacatacag aacaatatcg 610621 ttttccaaag gatttttggt ggggatcatc cgcttcagca acacaaatgg agggtgccgc 610681 cgacagagac ggaaaaggcc agaatatatg ggattattgg tttgaaaaag aaccgcatcg 610741 tttttttgat catgtcggac ccgcagacac atcccaattt tacgacaact ataaagaaga 610801 tatcaggctg atgaaggaac ttggccacaa ctcgttccgg atgtcgattt cctggtcacg 610861 tttaatacca aacggaacgg gcgagatcaa cgataaagcc gcagatttct ataacaatgt 610921 cattgatgag ctgatcgcta acggaattga accttttgtc aatttgtttc atttcgatat 610981 gccgatggcg cttcaaaaaa tcggcggctg ggtcaacaga gagacggttg acgcgtatga 611041 aaactatgca agaacttgct tccgtttgtt tggcggccgg gtgaaaaaat ggttcacgca 611101 taatgaacca atcgttcccg tagaaggcgg atacctatat gattttcatt atccaaacaa 611161 ggtcgatttt aaagaggccg tccaggttgg atttcatacg atgctatcaa gtgcccgcgc 611221 cattcaggct tacagggaga tgaagcagga cggaaaaatc ggcatcatct taaatttgac 611281 cccttcatac ccgagaagca gccatccggc ggatgtgaaa gccggggaaa tcgcagacgc 611341 gttttttaac agatcttttt tagacccatc tgtcaaaggc gaatttccca aagagctggt 611401 tgacattttg aagcatgaag gctttatgcc tgattacaac gctgaagatc tcgacatcat 611461 caaaaagaac acggttgacc tgttgggagt gaattattac cagccgagac gtgtgaaagc 611521 gaaagaacat cttccgaatc ccgacgctcc ttttttgccg gacaggtatt ttgatcccta 611581 cgtcatgccg ggccgcaaaa tgaatccgca tcgcggctgg gagatctatg aaaaaggcgt 611641 ttatgatatt ttgatcaatt taaaagaaaa ctacggcaac atcgagtgtt ttatctctga 611701 aaacggtatg ggggttgaag gtgaagagcg attcagggat gaacaaggca tcattcagga 611761 tgattaccgg attgaattta taaaagagca cctcaaatgg attcaccgcg ccatacagga 611821 aggctcgaac gtaaaaggct atcacttatg gacgttcatg gacaactggt cttggacaaa 611881 tgcctataaa aaccgatacg gatttgtatc agtcaatctt gagaaagacg gagaaagaac 611941 cgtcaaaaag agcggaaaat ggttcaaaga ggttgctgag catagcggtt tctagatttt 612001 cctaaaggtc aagatcttcc ggcaatcatc ataacgaata gagatgacga aaatccgcaa 612061 cattgatgaa atagggaaaa gaacttatga tatccgtaaa agcttatgtg atatcaaaca 612121 gctgccggag gataccaatg aataaatacg aaatcattgc aaatgaaatg agaaatagaa 612181 ttaaaaataa cgtatatccg atcgatcagc ccattcctga tgaagtatct cttgcaaaag 612241 aatttaactc aagccgcatg acgatgaaga gagccttgga taatttagtt gccgagggtc 612301 tgctgtttag aaaacgaggc catggcacgt ttattattca atctgcaata caggatgacc 612361 atgtccatgt agtcagcaat gagattctcg gattgaccaa cttgctgaaa gataaaaaaa 612421 tcaaaagcaa ggtcattcag tttgaagtgc aatttcccac tgaggaagtg gccgcccatt 612481 tgtctattga tcagaaaaca ccggtttatt atgtcgttcg gctgcgaatt gtagaaggtg 612541 aaccctatgt attagaaaaa acatatatgc cgactcattt aataccgggc attaatgacg 612601 atgtccttca tgattcgatc tacaatcata ttacaaatgt gctgcagctc aaaatcgccg 612661 gaacgcatcg gaaaatcaga gcctgcaaat ctgatcatat tgaccagcag catctgggct 612721 gtaaacagga tgatccaatt cttgaagtgg aacatgtggg cttcttagat accgggattc 612781 catttgaata ttccttttca cgtcatcggc atgacaagtt tgttgtgact tctgtaaaca 612841 tacggcgctg attgcggaga caacaaggag gccatctgca tgcttggcgg tattgaagca 612901 ggcggcacaa agtttgtttg tgctgtcggt agagaagatg gaacgatcat tgacaggata 612961 gaattcccca caaagatgcc ggatgaaacg atagagaaag taattcaata ttttagccaa 613021 ttttcattac aggcaatcgg catcggctcc tttggtcccg ttgataacga taaaaccagt 613081 caaacatacg gtaccattac ggccacgccg aaagcgggct ggagacacta tccctttttg 613141 caaaccgtta agaacgaaat gaagatccca gtcggattta gtacagatgt caacgctgcg 613201 gcgctgggtg aattcctttt cggtgaagcg aagggtcttg acagctgcct gtatataacg 613261 attggcactg gcatcggagc gggggctatt gtagagggga ggctccttca ggggctgtca 613321 cacccagaga tgggccatat ttatatccgg aggcacccgg atgacgtata ccaagggaag 613381 tgcccttatc atggagattg ctttgaaggc ttagcttcag gccccgctat cgaagcccgc 613441 tgggggaaaa aagccgcgga tttatcagat atagcacaag tctgggaact ggaagggtac 613501 tatattgccc aagcactggc tcagtatatt ttgatccttg cacctaaaaa aatcattctt 613561 ggcggcggcg tcatgcaaca gaaacaagtg ttttcttata tctatcaata tgtaccaaaa 613621 atcatgaaca gctacttaga tttttctgaa ttatcagatg atataagtga ttatattgta 613681 cctccacgtt taggcagtaa cgccggaatc atcggcacgc tagttttagc gcatcaggcc 613741 ttacaagcag aggcagcatc cggggaggtg cgatcatgac gcatccatta tttttagagc 613801 ctgtctttaa agaaagacta tggggaggga cgaagcttcg tgacgctttt ggctacgcaa 613861 taccctcaca aaaaacaggt gagtgctggg ccgtttctgc acatgcccat ggctcgtcgt 613921 ctgtaaaaaa tggcccgctg gcaggaaaga cacttgatca agtatggaaa gatcatccag 613981 agatattcgg gtttccggat ggtaaggtgt ttccgctgct ggtaaagctg ctggacgcca 614041 atatggatct ctccgtgcaa gtccatcctg atgatgatta tgcaaaactg cacgaaaatg 614101 gcgaccttgg taaaacggag tgctggtata tcattgattg caaagatgac gccgaactaa 614161 ttttgggaca tcatgcaagc acaaaggaag agttcaaaca acgaatagaa agcggtgatt 614221 ggaacgggct gctgaggcga atcaaaatca agccaggaga tttcttttat gtgccaagcg 614281 gtacactcca tgctttatgt aagggaaccc ttgtccttga aatccagcaa aactctgata 614341 caacatatcg cgtatacgat tatgaccgct gtaatgacca gggccaaaaa agaactcttc 614401 atatagaaaa agccatggaa gtcataacga taccgcatat cgataaagtg catacaccgg 614461 aagtaaaaga agttggtaac gctgagatca ttgtttatgt gcaatcagat tatttctcag 614521 tgtacaaatg gaagattagc ggccgagctg cttttccttc atatcaaacc tatttgctgg 614581 ggagtgttct gagcggatca ggacgaatca taaataatgg tattcagtat gaatgcaatg 614641 caggctcaca ctttattctg cctgcgcatt ttggagaatt tacaatagaa ggaacatgtg 614701 aattcatgat atctcatcct taatgaatgg gggagttgca tttgtttaag aaacatacga 614761 tctctttgct cattatattt ttacttgcgt ctgctgtttt agcaaaacca attgaagcgc 614821 atactgtgtc gcctgtgaat cctaatgccc agcagacaac aaaaacagtg atgaactggc 614881 ttgcgcacct gccgaaccga acggaaaaca gagtcctttc cggagcgttc ggaggttaca 614941 gccatgacac attttctatg gctgaggctg atagaatccg aagcgccacc gggcaatcgc 615001 ctgctattta tggctgcgat tatgccagag gatggcttga aacagcaaat attgaagatt 615061 caatagatgt aagctgcaac ggcgatttaa tgtcgtattg gaaaaatggc ggaattccgc 615121 aaatcagttt gcacctggcg aaccctgctt ttcagtcagg gcattttaaa acaccgatta 615181 caaatgatca gtataaaaaa atactagatt cttcaacagt agaaggaaag cggctaaatg 615241 ccatgctcag caaaattgct gacggacttc aagagttgga gaaccaaggt gtgcctgttc 615301 tgttcaggcc gctgcatgaa atgaacggcg aatggttttg gtggggactc acatcatata 615361 accaaaagga taatgaaaga atctctctat ataaacagct ctacaagaaa atctatcatt 615421 atatgaccga cacaagagga cttgatcatt tgatttgggt ttactctccc gacgccaacc 615481 gagattttaa aactgatttt tacccgggcg cgtcttacgt ggatattgtc ggattagatg 615541 cgtattttca agatgcctac tcgatcaatg gatacgatca gctaacagcg cttaataaac 615601 catttgcttt tacagaagtc ggcccgcaaa cagcaaacgg cagcttcgat tacagcctgt 615661 tcatcaatgc aataaaacaa aaatatccta aaaccattta ctttctggca tggaatgatg 615721 aatggagcgc agcagtaaac aagggtgctt cagctttata tcatgacagc tggacactca 615781 acaagggaga aatatggaat ggtgattctt taacgccaat cgttgagtga atccgtaatg 615841 tcacaattaa gaaggtgctc aagaagtttc ttgagcacct tcccactgga ttaagcattc 615901 atatcgccta acccaggact gtgttcattt ggtatttcag gaagcactgg tacgggaaac 615961 cctgccggag gatctattac ttgtaactct ccgccatttc ggcttggaga tttcccttga 616021 tagatttcac tgattctcgt ttcatccaac ctaaagttaa aatgtgtatt atggtagcct 616081 aattcgacat actttctgca ctcaggatat ttattaatgt cataattcgg cacagggagc 616141 agcttcgccc attcaacgcc caatgtctcg agcgctttcg cgaatgcatt ctggtgagca 616201 ttgtcgcgta caatcagaaa agcaagtgtt tcgcggaacg tctgattaga gctcatttca 616261 taaattcttg ttttttgcag cacacctgtc gactcaagaa gcaggttatc cagcaggtca 616321 gtaattaagt ttccgtggtt atacacccac gacccgttcc acggattgcc ccctgcatca 616381 acaggaaggg aactttgcgc tccaataata taatgatgag gattagcatg tttaaccgct 616441 tcatcaagtg gcgcttgatc tgtaccttga ctgccgacac cttcaccgcc tgattcatct 616501 aataaagcat tgattgtgtt ttgaaccagt tcaacgtggg caatctcctc taaaaaaatg 616561 ccgcgaagca gatcgcggta ctgtttctgc tttcctctga aattagagct ttggaaaaaa 616621 actgcatcat tgtacgcatt tctccgtaat gaccgcctaa tatctcctgc aggaccttag 616681 cagctgccgg gtctggcttg tccggtttaa tgatattaat cagttcctct ttgtagtaat 616741 acataacacg cctcatttct tcttaagaga ttttcttata ttatttgtaa gatgagataa 616801 aatatataca tgataagcat gggaaggcgt gaaagaagaa aataaaaaaa tacaggaaaa 616861 gtgttgacca aataaaacag gcatggtata ttattaaacg tcgctgatga acagcgtgaa 616921 acaaaacaga aaaacaaaaa agttttccta aggtgtttac aagattttaa aaatgtgtat 616981 aataagaaaa gtcgaattga aaaagattcg aaaaaacatt aaaaaacttc ttgacttcaa 617041 catcaaatga tagtatgata gttaagtcgc tcaataagcg cccgtagctc aattggatag 617101 agcgtttgac tacggatcaa aaggttaggg gttcgactcc tctcgggcgc gccatataag 617161 ataccacgcg ggtgtagttt agtggtaaaa cctcagcctt ccaagctgat gtcgtgagtt 617221 cgattctcat cacccgctcc attattgaat gatctttgaa aactaaacaa gacaaaacgt 617281 acctgttaat tcagtttttg aaaatcgcac agcgatgtgc gtagtcagtc aaactagggc 617341 ctgcacgatg caggtcacac aggtgtcacc gcgggatgcg gtggacttaa cctgtgatcc 617401 atttatcgga gagtttgatc ctggctcagg acgaacgctg gcggcgtgcc taatacatgc 617461 aagtcgagcg aacagatggg agcttgctcc ctgatgttag cggcggacgg gtgagtaaca 617521 cgtgggtaac ctgcctgtaa gactgggata actccgggaa accggggcta ataccggatg 617581 gttgtttgaa ccgcatggtt caaacataaa aggtggcttc ggctaccact tacagatgga 617641 cccgcggcgc attagctagt tggtgaggta atggctcacc aaggcaacga tgcgtagccg 617701 acctgagagg gtgatcggcc acactgggac tgagacacgg cccagactcc tacgggaggc 617761 agcagtaggg aatcttccgc aatggacgaa agtctgacgg agcaacgccg cgtgagtgat 617821 gaaggttttc ggatcgtaaa gctctgttgt tagggaagaa caagtaccgt tcgaataggg 617881 cggtaccttg acggtaccta accagaaagc cacggctaac tacgtgccag cagccgcggt 617941 aatacgtagg tggcaagcgt tgtccggaat tattgggcgt aaagggctcg caggcggttt 618001 cttaagtctg atgtgaaagc ccccggctca accggggagg gtcattggaa actgggaaac 618061 ttgagtgcag aagaggagag tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg 618121 aggaacacca gtggcgaagg cgactctctg gtctgtaact gacgctgagg agcgaaagcg 618181 tggggagcga acaggattag ataccctggt agtccacgcc gtaaacgatg agtgctaagt 618241 gttagggggt ttccgcccct tagtgctgca gctaacgcat taagcactcc gcctggggag 618301 tacggtcgca agactgaaac tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat 618361 gtggtttaat tcgaagcaac gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc 618421 tagagatagg acgtcccctt cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct 618481 cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccttgatc ttagttgcca 618541 gcattcagtt gggcactcta aggtgactgc cggtgacaaa ccggaggaag gtggggatga 618601 cgtcaaatca tcatgcccct tatgacctgg gctacacacg tgctacaatg gacagaacaa 618661 agggcagcga aaccgcgagg ttaagccaat cccacaaatc tgttctcagt tcggatcgca 618721 gtctgcaact cgactgcgtg aagctggaat cgctagtaat cgcggatcag catgccgcgg 618781 tgaatacgtt cccgggcctt gtacacaccg cccgtcacac cacgagagtt tgtaacaccc 618841 gaagtcggtg aggtaacctt ttaggagcca gccgccgaag gtgggacaga tgattggggt 618901 gaagtcgtaa caaggtagcc gtatcggaag gtgcggctgg atcacctcct ttctaaggat 618961 attatacgga atataagacc ttgggtctta taaacagaac gttccctgtc ttgtttagtt 619021 ttgaaggatc attccttcga aacgtgttct ttgaaaacta gataacagta gacatcacat 619081 tcaattagta atacaagata tcacatagtg attcttttta acggttaagt tagaaagggc 619141 gcacggtgga tgccttggca ctaggagccg atgaaggacg ggacgaacac cgatatgctt 619201 cggggagctg taagcaagct ttgatccgga gatttccgaa tggggaaacc caccactcgt 619261 aatggagtgg tatccatatc tgaattcata ggatatgaga aggcagaccc ggggaactga 619321 aacatctaag tacccggagg aagagaaagc aaatgcgatt ccctgagtag cggcgagcga 619381 aacgggatta gcccaaacca agaggcttgc ctcttggggt tgtaggacac tctgtacgga 619441 gttacaaagg aacgaggtag atgaagaggt ctggaaaggc ccgccatagg aggtaacagc 619501 cctgtagtca aaacttcgtt ctctcctgag tggatcctga gtacggcgga acacgtgaaa 619561 ttccgtcgga atccgggagg accatctccc aaggctaaat actccctagt gaccgatagt 619621 gaaccagtac cgtgagggaa aggtgaaaag caccccggaa ggggagtgaa agagatcctg 619681 aaaccgtgtg cctacaagta gtcagagccc gttaacgggt gatggcgtgc cttttgtaga 619741 atgaaccggc gagttacgat cccgtgcaag gttaagcaga agatgcggag ccgcagcgaa 619801 agcgagtctg aatagggcgc atgagtacgt ggtcgtagac ccgaaaccag gtgatctacc 619861 catgtccagg gtgaagttca ggtaacactg aatggaggcc cgaacccacg cacgttgaaa 619921 agtgcgggga tgaggtgtgg gtaggggtga aatgccaatc gaacctggag atagctggtt 619981 ctctccgaaa tagctttagg gctagcctca aggtaagagt cttggaggta gagcactgat 620041 tggactaggg gcccctaccg ggttaccgaa ttcagtcaaa ctccgaatgc caatgactta 620101 tccttgggag tcagactgcg agtgataaga tccgtagtcg aaagggaaac agcccagacc 620161 gccagctaag gtcccaaagt atacgttaag tggaaaagga tgtggagttg cttagacaac 620221 caggatgttg gcttagaagc agccaccatt taaagagtgc gtaatagctc actggtcgag 620281 tgactctgcg ccgaaaatgt accggggcta aacgtatcac cgaagctgcg gactgttctt 620341 cgaacagtgg taggagagcg ttctaagggc tgtgaagcca gaccggaagg actggtggag 620401 cgcttagaag tgagaatgcc ggtatgagta gcgaaagagg ggtgagaatc ccctccaccg 620461 aatgcctaag gtttcctgag gaaggctcgt ccgctcaggg ttagtcggga cctaagccga 620521 ggccgaaagg cgtaggcgat ggacaacagg ttgatattcc tgtaccacct cctcaccatt 620581 tgagcaatgg ggggacgcag gaggataggg taagcgcggt attggatatc cgcgtccaag 620641 cagttaggct gggaaatagg caaatccgtt tcccataagg ctgagctgtg atggcgagcg 620701 aaatatagta gcgaagttcc tgattccaca ctgccaagaa aagcctctag cgaggtgaga 620761 ggtgcccgta ccgcaaaccg acacaggtag gcgaggagag aatcctaagg tgatcgagag 620821 aactctcgtt aaggaactcg gcaaaatgac cccgtaactt cgggagaagg ggtgctctgt 620881 tagggtgcaa gcccgagaga gccgcagtga ataggcccag gcgactgttt agcaaaaaca 620941 caggtctctg cgaagccgta aggcgaagta taggggctga cgcctgcccg gtgctggaag 621001 gttaagagga gcgcttagcg taagcgaagg tgcgaattga agccccagta aacggcggcc 621061 gtaactataa cggtcctaag gtagcgaaat tccttgtcgg gtaagttccg acccgcacga 621121 aaggcgcaac gatctgggca ctgtctcaac gagagactcg gtgaaattat agtacctgtg 621181 aagatgcagg ttacccgcga caggacggaa agaccccgtg gagctttact gcagcctgat 621241 attgaatgtt ggtacagctt gtacaggata ggtaggagcc ttggaaaccg gagcgccagc 621301 ttcggtggag gcatcggtgg gatactaccc tggctgtatt gaccttctaa cccgccgccc 621361 ttatcgggcg gggagacagt gtcaggtggg cagtttgact ggggcggtcg cctcctaaaa 621421 ggtaacggag gcgcccaaag gttccctcag aatggttgga aatcattcgc agagtgtaaa 621481 ggcacaaggg agcttgactg cgagacctac aagtcgagca gggacgaaag tcgggcttag 621541 tgatccggtg gttccgcatg gaagggccat cgctcaacgg ataaaagcta ccccggggat 621601 aacaggctta tctcccccaa gagtccacat cgacggggag gtttggcacc tcgatgtcgg 621661 ctcatcgcat cctggggctg tagtcggtcc caagggttgg gctgttcgcc cattaaagcg 621721 gtacgcgagc tgggttcaga acgtcgtgag acagttcggt ccctatccgt cgcgggcgca 621781 ggaaatttga gaggagctgt ccttagtacg agaggaccgg gatggacgca ccgctggtgt 621841 accagttgtt ctgccaaggg catcgctggg tagctatgtg cggacgggat aagtgctgaa 621901 agcatctaag catgaagccc ccctcaagat gagatttccc attccgcaag gaagtaagat 621961 ccctgaaaga tgatcaggtt gataggtctg aggtggaagt gtggcgacac atggagctga 622021 cagatactaa tcgatcgagg acttaaccat atttttgaat gatgtcacac ctgttatcta 622081 gttttgagag aacactctca atttgtttgg tggcgatagc gaagaggtca cacccgttcc 622141 cataccgaac acggaagtta agctcttcag cgccgatggt agtcgggggt ttccccctgt 622201 gagagtagga cgccgccaag cattactttt atcatcgcgg ggtggagcag ttcggtagct 622261 cgtcgggctc ataacccgaa ggtcgcaggt tcaaatcctg cccccgcaac caaatatatg 622321 gttaaataag gagtgcccta agggtgcaac caaaataatc ctatacaaat atggtccggt 622381 agttcagttg gttagaatgc ctgcctgtca cgcaggaggt cgcgggttcg agtcccgtcc 622441 ggaccgccat taatgtaaac gaaacgatca tgttttcgtt ttttttgtgt tttcttttac 622501 tgtatcttct gcttggtgtc atagccaagc tttctttata tcgggaacat cttggatatt 622561 ccagcaaaat tcgataaact aggaagagca caaataggca taagcagggt tgaaaggagg 622621 ttttggttca tggatgaatt tgatttgata catagcatta ctccgcggac cattcaccat 622681 tcttccgttg atgtaggaat aggtgatgat gcagcgctct acactgcgaa acacggcgtt 622741 caggaaattg tttgtgttga tactatggta gaagacgtgc acttcaaatt acactattcc 622801 tcacctgaag atatcgggta caaggcgtta gccgttaata taagtgatat tgccgcgatg 622861 ggaggcattc ctaagtttta tctggtatca cttgcggtac cttcaaaatg gactgaatct 622921 gaaatcaagg cgatgtatga aggaatgaat gaactggcga aactatatca tatggatctg 622981 attggcggcg atacagtttc taccgctgac aaattagtcg ttacagtcac tgtaatcggt 623041 gaaattgaaa agggacaggc ctgtttgcgc agcttggcaa aaccgaatga tattgtgttt 623101 gtaaccggtg aaatcggttc ttctgcagca gggctttctt tattgctgga agagactaat 623161 cctcaaaact catctgtgga aacggattac tttatccaca ggcataaacg gcctgagcca 623221 agagtaagcg tcggcagatt atgctcgatt tttaaacggg cagctttaaa tgatgttagt 623281 gacggattgg ctagtgaact gaacgagatt gcagaagcca gctgtgtttc aattgaaatt 623341 gttgaaagca tgcttccaat tcattctgat ttgcctaagc ttcatcctaa ctggaaagaa 623401 tgggctttgt ttggcggtga ggattttgag ctgacaggga cggtttcaaa tgaggagtgg 623461 gaagtgttga agcaggagtg cgcagcgctt catcttccca ttacaaagat tggctatgtc 623521 agggaaaaaa caaaatctaa agtgatccta aaaacagatc aaacatcaat gatcttagag 623581 aaaaagggat ataatcattt taaataagac gggtgactcg tgtgaagcaa ttaaaatgga 623641 gaactgtaaa tccagaagaa acaaaagcaa ttgccaagct gacggcagcg tttgctaaac 623701 cgggagacgt cctgacatta gagggcgatt taggtgcagg aaaaacgact tttacgaaag 623761 gttttgcaga agggctggga attacacgta ttgtaaacag tccgactttt acaattataa 623821 aagaatataa cgatggcgta cttcctcttt atcacatgga tgtgtataga atggaagatg 623881 aaagtgaaga tttgggactt gatgaatatt ttcacggaca aggtgtctgt ctcgttgaat 623941 gggctcattt aattgaagaa cagctgccac aggagcgact gcaaattgtc atcaaaagag 624001 ctggtgatga tgagcgggaa attaccttta ctgctgtcgg gaatcggtat gaaatgcttt 624061 gtgaggagtt aagtagacat gacaatatta gcaattgata catcaaatta tacattgggc 624121 attgcgctgc ttcgagaaga cactgttata gcagaataca ttacatattt gaaaaagaac 624181 cactctgtaa gagcgatgcc tgctgttcat tcattgctga atgattgtga tatggcaccg 624241 caggaccttt ctaaaattgt cgttgcaaaa ggccctggtt catacacagg agtaagaata 624301 ggtgtgacgt tggccaaaac acttgcctgg tctttagaca ttccaataag tgctgtatca 624361 agtcttgaga cgcttgcggc aaatggccgg cattttgacg gtctgatcag cccaatcttt 624421 gatgctagac ggggacaggt gtacacaggt ctgtatcaat ataaaaatgg gcttttagag 624481 caagttgttc cagatcaaaa tgtgatgctg gcagattggc tggagatgct aaaagaaaag 624541 gaccgccctg ttttgttttt aggccatgat acttctcttc acaagcagat gatcgaggat 624601 gtgcttggaa caaaaggatt cattggaact gccgcccagc ataacccgcg cccttcagaa 624661 ttggcttttc tcgggaagga aaaggaagca gctgatgttc atgggcttgt cccggattac 624721 ttgcggctgg cagaagctga agcgaaatgg attgaaagtc aaaagtaggg tgataggatg 624781 aaaacaaaag cagcggtcag aaatatgcgg cttgaagata tagatcacgt atacgaaatc 624841 gaagcatcct cctttacgtc tccttggacg aaggattcgt tttatcatga gctgctggaa 624901 aatccgtatg ctcattatct cgtgattgaa aaggacggcc atcttgctgg gtattgcggg 624961 atttggattg tgatggacga tgcccagatt acaaatatag cgataaaacc agagtatcgc 625021 ggccagtctt taggagaaac gctttttcgc tcagctgttg aactgtgcaa agaaaaagac 625081 gcaaggcggc tttcgcttga agtgagggtt tcgaatcatc ctgctcaagg cttatataag 625141 aaattcggga tgcagcccgg cggaataaga aagaactatt atactgataa cggggaagat 625201 gcgttaatta tgtgggtgac gataaatgag tgagcaaaaa gacatgtacg tattaggaat 625261 tgaaacaagc tgtgatgaga ctgctgcagc tattgtgaaa aacgggaaag agatcatttc 625321 aaacgtagta gcctctcaaa ttgaaagcca taagcgcttc ggaggcgttg ttccggaaat 625381 tgcttcaaga catcatgttg aacaaatcac tttggttata gaagaggcgt ttcgcaaagc 625441 tggcatgacg tatagtgata ttgatgcgat tgcagtaaca gaaggtccgg gactggtggg 625501 agcgcttctt atcggagtga atgccgctaa agcattgagc tttgcatata acattccgtt 625561 agtaggcgtt catcatatag ccggtcatat atacgcgaac cgtcttgtag aagacatcgt 625621 gttcccggca ctggcattgg tcgtttcagg aggccataca gaactggttt atatgaagga 625681 acatggatca tttgaagtca ttggggaaac ccttgatgat gcggcaggag aagcctacga 625741 caaagtggcg cggacgatgg gattgccata tccgggtgga ccgcaaattg acaagctagc 625801 tgaaaaaggg aatgacaata ttccgcttcc tcgcgcatgg cttgaagaag gctcttacaa 625861 cttcagcttt agcggattga agtctgcggt gatcaatacg cttcataatg catcccaaaa 625921 agggcaagag attgctccgg aagatttgtc tgccagtttc caaaatagtg tgatcgatgt 625981 cttggtaacc aaaacggcgc gcgcggcaaa ggaatatgat gtcaaacagg tccttttagc 626041 cggaggagta gctgcaaaca gaggcctcag agctgcatta gaaaaggaat ttgcccagca 626101 tgaagggatt acgcttgtca ttcctccatt agctttatgc acggataatg ctgcgatgat 626161 tgctgctgct ggtacaattg cttttgaaaa aggaattcgc ggtgcatatg atatgaatgg 626221 ccagcccggc cttgaattga cttcttatca aagtctcacg agataatagc gtgagacttt 626281 ttatctgttt gttattaaca gacaattcac aatttatcca catatctgtg agtaattata 626341 gagatattga tggataaagg gctgaggtca ctgttaataa agtggataaa ttcagaatat 626401 tttgtggata gtgtgtataa agcgcttact ttgtttattt attaggggat gttctgtgga 626461 taaaaagcac ctctaaaaag aggtgcttga cttttttaat cttcttctgt ggatagttct 626521 tcccattcgg acaaaagaga ttccagctcc tgattaagct tctcattgtc tgcatggata 626581 gcttgtactt tttcatgatc ctgatagact tcagggtcac atagcaattc atcattgcgg 626641 ctgatgttct cctcaatggt ttgaacggtg gtttcaattt cttcaatccg acggagtcgt 626701 tggcgctctt tctttttcca ttctttttct tcctcgtagg aacgtttgga gtcagacttc 626761 actgtagctg gcgttttatc agtttcctct tgctgattca ttttctccaa ttcaagctgc 626821 tctgtttttt tctctgtata ataatcgtaa tctcccagat actcctctat atggcttgaa 626881 gaaagctcca atactcttgt ggcgattctg ttaataaaat atctgtcatg tgagacaaat 626941 aacagtgtgc ctggataatc aatcagcgcg ttttcgagaa cttctttgct gtctaaatcc 627001 agatggttcg tcggttcatc aaggatgaga aagttggctt tttgaagcat cagcttagct 627061 agagccaatc ttgctttttc gcctccgctc agtgaatgaa ctggtttcag cacatcatct 627121 ccggagaata agaaatttcc gagacacgtt ctgatttctt tttctgggag cccggggtac 627181 tcgtcccaca gctcatcaag gacacgttta gaggaagtca actcagcctg ttcctggtca 627241 taatagccga cactgacatt tgagccgtaa gaaattgttc cctgatctgg ttttagggtg 627301 tctattaatg ttttcagcaa tgtcgattta cctattccgt tagggccgac aagcgcagcg 627361 ctttctcctc ttgtgagcat gaatgacact tctgttaaaa gcggcggctg gttttcatag 627421 ctgattgtga gatcctgaac acgaaggact tcatttccgc tctgttttgt aatatcaaaa 627481 tgaaagtttg cggatttttc atcgccaagc ggttttgaca tgacatccat tcgctcaagc 627541 tgctttctgc ggctttgcgc ccttttggtg gtagaggctc tcgccagatt tcgatctacg 627601 aagtcctgca gctttgcaat ctcgtcctgc tgcttttcat acattttcag atctttttca 627661 tactgcgcgg ctttttggtc gagataagcg ctgtagttgc cgtgatactt tttgctttct 627721 gctcttgata cctcgtatac ctggtttact actttgtcca aaaagtagcg gtcatgcgaa 627781 acgatgagaa tggcgcctga atagccttgt aaataatgct caagccaggt aagcgtatca 627841 atatccagat ggtttgtcgg ctcatcaaga atgagcaaat caggctgtgt taatagaagc 627901 ttacctaaag ccagtcttgt tttctggcct ccgctgaggc tttgaacctg tgtagaatcg 627961 tcaaaatggc tgaagccgag accatgcagc acagatctaa catccgcttc atattgataa 628021 ccgcctttat ctttgaattc ctgctgaaga cggtcgtagg ttttcatgat gctttctaat 628081 tcacccgggt cagctgccgc cattttttct tccatagccc gcatttcctt ttccattgct 628141 tttaagtggt caaaaacagt cagcagctct tcttttatgg taagcttaga atccaagcca 628201 gtatgctggg cgagatatcc cattgtaata tctttcggtt taataatttc gcccttttca 628261 tacgaaagct ggcctgcgat aattttaagg agcgtggatt ttccggcgcc atttcttcct 628321 acaatggcga tgcgatcacg atttctgact tccagcttta tattgtttaa aatagtatca 628381 gcaccaaatg atttggacag ctgattaact tgtaagatca tcatattatt tcacctctgc 628441 tataataagt taagtgtagc ttatgaacca gaagtcagca aacaatacat tggccatata 628501 agacatagag aagaaaatag tgtatgatct gtttaaggag cgttttaata tgaatggatt 628561 ttctcatttt aatgaacagg gcagagccca gatggtggat attagcgaaa aatcttcgac 628621 tgtccgtact gcggcggctg tttcaagcgt acacatgaag aatgaagtgt acgagaaaat 628681 acaaagtcac gatatcggca aaggagatgt actggctgtc gcacaggtgg caggcattat 628741 ggccgcaaag caaacgtcga atatcattcc gatgtgccat ccgctttcat tgagcggggt 628801 agatatatcg tttgactgga aaataaaaga agcagaagtt atacttcata taaaagcaca 628861 ggtcaaaacg aaagggagta caggtgtgga aatggaagcg ctcacttctg catcggtgtg 628921 cgctcttacc gtttacgata tgtgcaaggc ccttgataag ggaatggtca tcggccctac 628981 tttcttgctg gagaagacag gcgggaaaaa cggtgacttt aaaagagaac tatccgagta 629041 taatttggag gaccaaaaat gaataaggat caatcaaaaa ttccgcaggc gacggcgaaa 629101 cggctgccgc tttactatcg ctttttaaag aatctgcatg cgtcaggaaa acagcgtgta 629161 tcatccgctg aactcagtga tgccgtaaag gttgattctg ccacgattcg gagggatttt 629221 tcctattttg gagctcttgg caaaaaagga tacggatata atgtggatta tttgctgtct 629281 tttttccgga aaacgcttga tcaggatgag atgacagacg tcatcttgat tggtgtcggg 629341 aacttgggaa cggcatttct tcactataat ttcacaaaaa acaataacac aaaaatttct 629401 atggcttttg atataaatga gagtaaaata ggaactgagg taggcggcgt gcccgtctat 629461 aaccttgatg accttgaaca acacgtaaaa gatgaatcag ttgccattct tacagtgcca 629521 gcagttgccg ctcaatccat tacagacaga ttggtcgcat taggaatcaa gggaatcctt 629581 aattttacgc cggcccgttt gaatgtgccg gaacacattc gaattcatca tatagattta 629641 gcagttgagc ttcagtcact ggtttatttt ttgaagcatt attcagtttt agaggaaatc 629701 gaatagaggg aaaggaggag cccaaatatg ccgatcggtc ctggaagcct tgctgttatc 629761 gcaatcgttg ctctgattat cttcggtccc aaaaagctgc ctgaattggg gaaagcagcg 629821 ggagacacac ttcgtgaatt taaaaacgct actaaaggat taacgagtga tgaagaggaa 629881 aaaaagaaag aagatcagta agttaggatg acacgaatga aagtgaatca aatgtcgctg 629941 ctggagcata ttgctgagct tcgaaaacgg ttgctgattg tagcgctggc gtttgtcgtt 630001 ttctttattg ctggattttt tttagcaaag ccgattattg tgtatctgca agaaacagat 630061 gaagcgaagc agcttacgct taacgcgttt aacctgacag acccgcttta tgtgtttatg 630121 caatttgcgt ttatcatcgg catagtcttg acctcgccgg ttattcttta tcagctttgg 630181 gcttttgtga gcccgggcct ctatgagaaa gagcgcaaag taacgctcag ctacattccg 630241 gtctctattt tgctgttttt agcgggctta tctttttcat attatatttt atttcctttt 630301 gttgttgatt ttatgaagcg gatttctcag gacttgaatg tcaatcaggt gatcggaatt 630361 aatgaatatt ttcattttct tctgcagctg acgattccgt ttggactgct gttccaaatg 630421 ccggtcatcc tcatgttttt gacaaggctc ggaattgtga caccgatgtt cttggcgaaa 630481 atcagaaagt atgcgtattt tacgctgctg gtgatcgcag ccctgattac accgcctgag 630541 cttctgtccc atatgatggt cacagtcccg cttttgattt tatatgaaat cagtatcctt 630601 atatcgaagg ccgcttatcg gaaagcacag aaaagcagtg ctgccgatcg ggacgtgtct 630661 tctgggcaat aataaaaaat ccatttctca tgcgagaaat ggattttctt tatttttggt 630721 tctttttgat tttaaatgaa aaggcgaaca tcttaaaaga aatgctgatg ttgtaagcgg 630781 cgaacaccat cagcaggatg gagtaaaatg accacatgct gcctggcgag cttgcggcaa 630841 gataagtaaa gatgcaccct acggcaaagt agatcattcc ccaaactacc gggtttctca 630901 taaaaataat cctccaataa tcaattgcat ttgtgtgctc tgctgttcaa ggtaattacg 630961 aacaggctca agctgcatga tgacgacgaa tgtattcatc attaaatggg cgaaaatcgg 631021 cacccatatc cgttttgttc tcgcatataa aaaggcaaag gtaaagccca ttgctgtata 631081 tagaaggaga tgcttcaaat cagcgtgaac aataccgaag ataaccgagc tgatcagtcc 631141 tgcgaaaaag aaattcgttt tttcgtacag cgcgccgaaa atgatttttc tgaagatgat 631201 ttcttctaat ataggcccga cgatggaaga aacgataatc atgagcggga ctgcctgaat 631261 gacatccaga atcgcttgtg tattttctga ttctcttccg atgccaaaaa cataatattc 631321 aatagagcct gctattcctt gagagaaaag ggcaatgaaa aaaccggcta tcgcccaaag 631381 gatagaaagt ccgattgagt ccttctgtcc gtttcgcagc gtttctttcg gaacggttct 631441 cagaatgagc agaacaacaa cgagacaggc gataaagctg ataacggacc ataatccttg 631501 tgcatgcagc atattttcat ctgtaggctg tcctccggca taaccgaatt taaataacaa 631561 gggaatcgcg attaatgcgg aaaactgcat gatgatatat gtcaaaataa taaaccaata 631621 ctgttttctc aaatggtatg tactcctttg ttaagtgggt ttcgttcatc tacagctatt 631681 gtaacataat cggtacgggg gtgaaaaagc taacggaaaa gggagcggaa aagaatgatg 631741 taagcgtgaa aaatttttta tcttatcact tgaaattgga agggagattc tttattataa 631801 gaattgtgtt agcactcttt agtgctgagt gctaaaatta catattcata ctattgagga 631861 ggttatttca ttgttaaagc cattaggtga tcgcgttgtc attgaactcg tagaatctga 631921 agaaaaaact gccagcggaa ttgtgttgcc ggattctgca aaagaaaaac cgcaagaagg 631981 caaaatcgtg gcagctggtt caggtcgcgt gttagaaagc ggagagcgcg ttgctttaga 632041 agtaaaagag ggcgaccgca ttatcttctc aaaatacgca ggtactgaag tgaaatacga 632101 aggtactgaa tacttaatct tacgtgaaag cgacatttta gctgttatcg gctaattctt 632161 aaataaacaa tacttaaaac atttgaggag gtcttgtaaa catggcaaaa gaaattaagt 632221 ttagtgaaga agctcgccgc gcaatgcttc gcggtgtcga tgcacttgct gatgctgtta 632281 aagtaacttt aggaccaaaa ggacgcaacg tggttctaga gaaaaaattc ggttctccgt 632341 taatcacaaa tgacggtgta acaatcgcta aagaaatcga gctagaagac gcgtttgaaa 632401 acatgggtgc taagcttgtt gctgaagtag ccagcaaaac aaacgacgtt gccggtgacg 632461 gtacaacaac tgcaacagtt cttgcgcaag caatgatccg tgaaggcctt aaaaacgtaa 632521 cagcaggcgc taaccctgta ggcgtgcgta aagggatgga acaagctgta gcggttgcga 632581 tcgaaaactt aaaagaaatt tctaagccaa tcgaaggcaa agagtctatc gctcaggttg 632641 ctgcgatctc tgctgctgat gaggaagtcg gaagccttat cgctgaagca atggagcgcg 632701 taggaaacga cggcgttatc acaatcgaag agtctaaagg cttcacaact gagcttgaag 632761 ttgttgaagg tatgcaattc gaccgcggat atgcgtctcc ttacatggta actgactctg 632821 ataagatgga agcggttctt gacaatcctt acatcttaat cacagacaaa aaaatcacaa 632881 acattcaaga aatccttcct gtgcttgagc aggttgttca gcaaggcaaa ccattgcttc 632941 tgatcgctga ggatgttgaa ggcgaagcac ttgctacact tgttgtgaac aaacttcgcg 633001 gcacattcaa cgcagtggct gttaaagctc ctggtttcgg tgatcgccgt aaagcaatgc 633061 ttgaagacat cgctgtcctt actggcggag aagtcatcac agaagatctt ggccttgacc 633121 tgaaatctac tcaaatcgct caattgggac gcgcttctaa agttgtcgtt actaaagaaa 633181 acacaacaat cgttgaaggc gctggcgaaa cagacaaaat ttctgcccgt gtgactcaaa 633241 tccgcgctca agtggaagaa acaacttctg aattcgacag agaaaaatta caagagcgtc 633301 ttgctaaact tgctggcggc gtagctgtca tcaaagtcgg cgctgcgact gaaactgagc 633361 tgaaagagcg taaacttcgc atcgaagacg ccttgaactc aactcgcgca gctgttgaag 633421 aaggcatcgt atccggtggt ggtacagcgc ttgtaaacgt atataacaaa gtcgctgcag 633481 ttgaagctga aggcgatgct caaacaggta tcaacatcgt gcttcgcgcg cttgaagagc 633541 caatccgtca aatcgcacac aacgctggcc ttgaaggatc tgtcatcgtt gagcgcctca 633601 aaaacgaaga aatcggcgta ggcttcaacg ctgcaactgg cgaatgggta aacatgatcg 633661 aaaaaggtat cgttgaccca acaaaagtta cacgctcagc tcttcaaaac gctgcgtctg 633721 tagctgcaat gttcttaaca acagaagctg ttgtcgctga caagccagaa gaaaacggtg 633781 gcggcgcagg aatgcctgat atgggcggca tgggcggtat gggtggaatg atgtaataaa 633841 gggatattaa cccttataca tcaatgtttt aaccgtctta aaaaactaga caaagcgtga 633901 ataaaaaaag agaaggtctt tcatcagttt actaaactgt tgggagacct tttctccata 633961 ttagcggtca tatgagcata aatgtccatc gtcgtattta tgtccgaatg accaaattgt 634021 tgctggattt ctttaatgcc tactcctgcc tcaattagta aggaggtatg ggtatgccta 634081 aaagagtggg gggtgacatt ctttttatcc cagctttttt gagcagccgt ttaagtctag 634141 tctcaataac ctttcttaat tgcggatgac catcctcccg ctcaaaaata aatgatgagt 634201 cttgataaat caatctattt ttaagcttaa tttcattttg ataaatttta ttttttttta 634261 gtagattgac atcgtttcat caattcgaac gatatcaaca gatcctgttg ttttaggtgt 634321 tagcaattgg tatttttcaa tttgattgtt aggggtgtat agggtctttg tgacctggct 634381 tatcattgaa atctgtccat tttaaagcaa gaagttcacc aattcttagg tcggtctagg 634441 caagtacggt aaagaccaaa tggtccattt ctagcccgtc agattgagcg agctttagaa 634501 aatgtgtcag cacctctttt tccaatgctt tgttgcttct tgggtaattg aaaatcccca 634561 gttgggttca ttttaataat cccttgagtt ttagcttttc ggaaaatcat acggccgcag 634621 gcatgaatac ctcccaaaca attgtgactg tattgctcgt tcagttctaa cgtgcggtct 634681 tcatacattt ttttgtgttt tgctaatcgg gtattgaccc aatactgcga taaaatgcat 634741 cattttcttt tcactggccc gtacactgct tatttttacc ccactccggt tgtaaatctt 634801 aagccaacct tttgcaaatg ttttgaaggg catatctgac tccttaataa aagtcccgtt 634861 gtcgttttgg agttctacgt gacgggctgc tactggggct tctttctttg ttttaaatct 634921 tcctttggat atttctagac gttttttggt taaagggtca atgcctagta gatatgataa 634981 ctccacgtct taccgcattg cttgagtttt gccatttatt tgtccctaac taattttttt 635041 tcatcaaatt ggtctttaag tgagtttaat aatttttgtt tctctcgact ggtcaataat 635101 tgcccttcat atttcaaaag attggataaa tttgagatgg aatcaatcct gatggatggt 635161 accgtagact ttaataagaa acgaaaggcc aactgcgact tcagttggcc tttcctattt 635221 ataataaaga aattgagtga gattgctgac agaactacgt actactcgtt ttctttagtt 635281 gcccttgcta atcgttcaac ctctccccga atcccaatcg caggctccca cgaatcaatc 635341 aaacgaatcg ccttctgatt agattccacc gctttcgttt tctctccttt acgatacaac 635401 agctgcgcca ttccgtagtg atagtagatc agttcaactt gattggcgtt atgtttgtca 635461 tagagcattt gctcaaaggc ttcttccgct ttttcaaact gatcacattt cacgtaagcg 635521 acacccagat tgaaataggc ttctatcgtt ttttcgccgc cgtatgtgga gctgatttca 635581 tttgccgctt cgtataattg aatggcttct acatgataac ctctcgcaaa gcttaagtca 635641 ccgcgaacca atagaactct gtgttgaatg gtaggggaaa tcggttgatt ttcgatttcg 635701 tttaaaattg tctctgcttt ttcctgttgc ccgtctttta aaaacagcct tgctttgagt 635761 gcatgtcccc aaacctttag atcataggca tcgtgagcgt ctgattgttc aagaatcttc 635821 agcccggctt ctatttgctg aagcgctccg tctaaatcat tgacttccat caatgcccag 635881 cctgaggtgt cgattcggaa gtacgcttct cgtgtgtgtt ggcctaagtg atgggcggcg 635941 tcggccgctt tgcgtccgta ttcgattcgc aggggcaggt tgattctgct tagaaaatgg 636001 ctaatgcggg tgatgagttc gattaggatt tctttttgtt cagtttcact tgcccattgg 636061 atgaccttta agatgtttgg ccattcttgt ttcatttgat ctaagttccg tcccagcagg 636121 tagctccaat agatagagtt gggctgttcc cgctttaaat gggtttcggc ataatcaata 636181 taatagtgcg cccagcgatt gcgggcttct ttttcatatt cgtgctgttc ggacaagtgc 636241 tgttctccgt aagcgacaac ggtttggtgc gctaagtatt gtgtcctgcc ttggcttcgt 636301 tccggctgaa tcagcgcata tgaccgcatt tgttccatag cgtaatgaaa acggcgggcg 636361 tctaatccgg ctgctgccgc caggcttttt tcatcaggcg gcttgctgaa aaagcaaagc 636421 gtctgccaga gctttcgcgt atcttcattg catctatccc aggtgcggcc aaagaggaat 636481 tcaaacaatt ccagcagtga gtagcctgct tttccaagct catgaatcag ctgctgagcg 636541 gggatgtcat cgtctgacat ataggcaatg ctgagtgcca tggctttcgg gtttccggca 636601 gtcgctgaaa tgaattcgtt tttcaggtca gatgatagat gtaacagctg ctccagcttt 636661 tcccgtttac gtgggaggtt gcatgtttgt aagcagtgat gcacttcttg ttgaaaaaat 636721 tcgtgggcat ctgtttggtc aagaccgctt agctgaatgg ctgtcatttc tccgaagctt 636781 tcccgataag tttgctttac gttttcccgc gctgtaagga gaacttttac gccttgcgga 636841 aggctggtga taaattcatg aatgtcacgt tctgcagtat caatgctgtc aacgatcagc 636901 aggatcggtt tttctctagt gtaattggct aacgcattgc ggacgacaaa ccgttttaca 636961 ttgattgatt tatcgatttg ttctttgcgt ccgagctgat aggcgatcgt atttaaaaaa 637021 tcgctaaagc ttaatccttt ccaatcagcg ctgacccaga tgatgctgtt gaatgccggc 637081 caaactgaag tatcgtcgac acaggaatag gcggcttcaa gagcaattgt ggtttttccc 637141 atgccggccc agccggtgat taaacagact ggtgatggag aaagcatcca ttgccgtatc 637201 gcttccatat caaagctgcg tccgataaag cgtccggacc agcgtgaggg taaattatgc 637261 gtgatgggct gttctgtaag cgcattcgtt tcttggccgg gtctgtcatg aaacagccgt 637321 tttactacat tttcaatttc gccttcactc ggagccccga ataatccgtc ttttcgcagt 637381 attttcgctt ttttcaaaca ggatgctgcc catacaggca atgcgggttt gatgactggg 637441 atagtggtgg cttccagcaa gtcggtcaac cactcgatat ccaagtcggt cttttcgaga 637501 atgatccaga tcattccgaa cagttttccg tcgtcgattc ttccgggaat gtagtttgcc 637561 cccatctgtc cgatccagct tttgatcgtg tttggggaga ctcccagctg gagtgcgatt 637621 ttatctatgt aagactgtcc tgttttttca ttctttttcc ttctgacttt ataatcagga 637681 tgaagtttta gcgttttgac gccaggtgcc agcatttgtg caaattgttt tcggttttca 637741 agttcagcca taagcctgca cctcctatta gtactatttt atcaatccag cgttttttgt 637801 atatgaaaaa ataaaagtac agtgccgctg tccttttata cagcaggaaa ggctgttgaa 637861 cgtgttaaaa agcagataaa atgggggcag taacagagaa aacaaaaatg tatgcactta 637921 cattttattt tctaaagaaa ggaacttgcc aaatgactca cacagtacct caaaacatga 637981 aagcggctgt tatgcacaac acaagagaga tcaaaattga aacattgcct gtgcctgata 638041 tcaatcatga tgaagtgttg attaaggtga tggctgtcgg aatttgcgga tctgatctgc 638101 attactatac aaatggccga ataggcaact atgttgtgga aaaaccattt atccttgggc 638161 atgaatgtgc gggtgaaatt gccgctgtcg gatcatctgt cgatcaattc aaggtgggag 638221 accgcgtcgc tgtagagccg ggtgttacgt gcggacgctg tgaggcgtgc aaagaaggac 638281 gctataatct ttgcccggat gtacagtttt tggctacacc gccggtagac ggtgcgtttg 638341 tccaatatat taaaatgcgt caggactttg tttttttaat cccagactca ctttcttatg 638401 aagaagctgc tttgatcgag ccgttttctg tcggtatcca tgcggcggcc agaacgaagc 638461 tacagcccgg atcaacgatt gcgattatgg ggatgggccc tgttgggtta atggctgttg 638521 ccgcagctaa agcatttggg gcaggcacaa tcattgtcac cgacttagag ccgctgcggt 638581 tagaagctgc gaaaaaaatg ggagcgactc acattattaa tatacgtgaa caggatgcac 638641 ttgaagagat taaaacgatc acgaatgata gaggcgttga tgttgcttgg gaaacagcag 638701 ggaatccagc ggcattgcaa tccgcactgg cttctgtgcg ccggggcgga aaattggcga 638761 ttgtcggttt gccttcacag aacgagattc cgctcaacgt gccgtttatt gcggataatg 638821 agattgatat ttacgggatc ttccgttatg ccaatacgta tccaaaggga atcgaatttc 638881 ttgcttcagg cattgtggac acgaagcatc tagtaacgga ccaatattcg ctggagcaga 638941 cgcaagatgc gatggagcgg gcgcttcaat ttaagaatga atgtttaaaa gtgatggtgt 639001 atccaaatcg ctgagtgaac agggaggatc ttcgtattct ccctcttgtt tactggaaat 639061 gaaaacggat tcttggggtg ggaaatgatg attggaacag aaaaagtaac ggcattgaag 639121 gcgaagcatc agtcaaaatc cagcaccggc ctgtcctggt ttgaacgaat cggttatgga 639181 ttcggcgata tgtcgtataa tattatcttt cagtttgtaa acgcatactt attattttat 639241 tatacagacg tcggcggcat tcagcctgcg gtaatcgcaa ctttgtttct tgttgtgcgt 639301 gtgctggatg ctatttttga cccgatcatg ggattgattt tagataaaac gaatacaagg 639361 tggggaaaag caaggccata tttgctgtgg gtggcatttc cttttgcgct attcacattc 639421 ttatgtttca cgacgcctca tttcggtgag accggaaata tggtatatgc gtatgtcact 639481 tatattctgc ttgggatgtc ctttagtatg caaacgatcc cggtgaacag cttaacgggg 639541 cggatgacga attcggtgga ggaacgaacg gttctgacca caacccggat gattttggtg 639601 tatatcggca ttcttttatc catttcctgt gcgacaccgc ttgcaactgc tatcggagga 639661 gaggatcagg cgtttggatt tcagatgacg gcgctcatct atgcggctgt cagcatcgtt 639721 ttgaatctat ttagtttctt tactgtacgg gagcggattc agcctaaaaa gagaaaaaaa 639781 caagggatca aaaagacgtt atccgtttta ttcaaaaaca aacccttgct catgttaatt 639841 tcatcatttt tggcttttgc gatcgggttt aatattaagc tcagcacgat ggtgtattat 639901 tttacgtata acgtaaacca taaagagttc gtgtttatgg gcaccgtttt atttttcggg 639961 gcagcgctga tcagcaattt gtttattcct ttcttttctg agaagtgggg cagaaaacaa 640021 gtcatgatta tcacggcagc tctatcgctt atttcttatg ccggcctgca ttttacgccg 640081 tattcttcaa ttccactcat tttcatttgg cttttcgctt cgggattttt cacaacgcct 640141 ttaaatacgc ttgcttgggg aatggttgcg gattgcgtcg attatgcgga atggaaaacc 640201 ggaattcgcg cggatggtgt tgtgatttcg agcatgagct ttattaataa gctgggtgtt 640261 gcgttagccg ggtcattttc ggccatttat ttaggaatcg ccgggtatgt ggcgaataca 640321 gaccagacag ttgcgtcgtt gaatgcgatt aaaaatatga atgctttgat tccgggattt 640381 ttcattttgc tttctattat tcttatcgcc ttctatcctt taacggaaaa aagatataaa 640441 cacatcatct ctgagctgga gcaaaggtct gcgagataaa tagatgtaaa atttttaata 640501 ttcaatgttg tatttatggc aaaaagtaat atactgagac tgtaatctag actttataaa 640561 tgagtgtgat aatatgcgta gtcattctgt agtttgtatt ggggaattgt tgattgattt 640621 cttttgtacc gatgttgacg ttgatttaat ggaagggcgc caattcctga aaagtgccgg 640681 cggggcaccg gcgaatgtgt cggcagcgat tgccaagctg ggcggagacg ccgctttcag 640741 cggaaaagta ggaaaggatc cgtttgggta ttttctgaag cgaacattgg acgctgtaca 640801 tgtcgatacc tctatgctgg tgatggatga gaaagcgcct acaacgcttg cttttgtttc 640861 attaaaacaa aatggagagc gtgactttgt ttttaataga ggcgcggacg ctttgtttac 640921 gctggaggac attgaccagg aaaaactaaa cgaagcgaaa atccttcatt tcggctctgc 640981 gacggcactg ttatcggatc cgttttgctc agcctattta cggttgatgt cgattgcgaa 641041 agacaatgga cagtttattt cgtttgaccc taactaccgt gaagatttat ggaggggaag 641101 agtctcagag tttgtaagtg ttgcgaaaaa agcgatcgct gtaagtgatt ttgtgaaagt 641161 cagtgacgag gaacttgaga ttatcagcgg tgtgaaggat catgaaaagg gagttgcgat 641221 ccttcatgag atcggagcca acattgtcgc tgtgacactt gggaaaagcg gaacgcttct 641281 ttccaatgga aaagaccgtg aaatcattcc aagcattccg gtgacatcaa ttgactcaac 641341 aggggcggga gatgcttttg tcggtgcggc tttatatcaa ttggcaaaca cggatcagat 641401 tcaatctgta gatgctgatt ttgtgaaact gcgtgagatt gtggcgtttg ccaataaggt 641461 cggagctctt gtgtgcacta aaattggagc gattgatgca ctgccgagtt tggatgagat 641521 tggagtttct ttgtaaatca ttgaagatgt ttcttgaaag tctttggact tttgggggca 641581 tcttttttta ttgcttacat ttttgttcag gtaaaaagtt gtatattttt tgtttgaaat 641641 gtcatttttt attaaaaaag tgaaactttt aacgataata aatagtatat gtaacaaggg 641701 ttaccgaatt agctttagga ggaacgatat aatgagtata attggaagat ttaaagatat 641761 tatgtctgcg aatatcaatg ctttattgga caaggctgaa aatccggaga aaatggtaga 641821 tcaatattta agaaatatga atagcgattt ggctaaggtt aaggcagaaa cagcagctgt 641881 tatggctgag gagcagagag caaaaagaga atatcacgaa tgccaggcgg atatggaaaa 641941 gatggaaagc tatgcaatga aggcgctgca agccgggaat gagagcgatg cgagaaaatt 642001 tcttgaaaga aaaacatctt tggagtcaaa gctttctgag ctgcaggcgg cgaatcaaat 642061 tgctgcaacc aatgccgcac agatgagaaa gatgcatgac aaattggtat ctgacattgg 642121 agagctggaa gcacgcaaaa atatgatcaa ggcgaagtgg gcagtagcga aaacgcaaga 642181 aagaatgaac aaactgggcg cttctgtttc aagtacaagc caatcaatgt ctgcattcgg 642241 ccgaatggag gacaaagtaa ataaggcact tgatcaggcc aatgcaatgg ctgaactgaa 642301 cagcgctccg caggatgata tggctgatct gtctgcaaag tatgacactg gcggttcaag 642361 ccaggttgat gatgaacttg cggcgttaaa agcgaaaatg atgctcgata agtaatacat 642421 aggaggccgc agctttcggc tgcggcgtca ttttatcata aaatgtgaga gggaacggta 642481 atgataatat cttataagtg tccgaactgc ggcagtgata tggcatttga cagtgaaacc 642541 ggctcgttat cctgcagcag ctgcggaaga caggacaata ttgaaagcct tccgaaagaa 642601 aacattgcgg cacggttttc tgatgatgaa gcaaaagaat atcaatgtaa aaactgcggt 642661 gccgttttga tcacggaagc tgaaacgaca gcaacgacgt gcagcttctg cggaggtgct 642721 gcaatacttg ccgatcgttt atcaggacat ttggcgccgg cgaaggtcat tccatttaca 642781 atcagcaagc aagaagcgga gcaggcattt cgaaagtggt gcaaaaaagg ccttctgaca 642841 ccaagaggtt tcatgtctgc tgatcgtatc aaaagcatca ccggcatgta tattccattt 642901 tggatgtttg atttaaatag tgaagtacag gtgagagcaa actgtaccag agtccatcaa 642961 tatgaagaag gggattatat ttgcacggaa acagagcact ttgaagcgtt tcgtgatatc 643021 aatctcgatt atttgaaaat ccctgtcgat gcctctgaaa aaatgaaaga cgaattaatg 643081 gacaaattgg agccttattc atacgaagag ctgaaggact ttcaaacggc atatttggcc 643141 ggttatattg cggaaaagta caattatacc gatgaggagc tttttccgag ggcaaaagag 643201 aaaatcagca gttatataga ttcatacatc cattctactt tttccggata tacgtcagtc 643261 aatgtgaggg acaaacatat tcacacgaaa aacgtgaaca gcttttacgt tttgcttcct 643321 gtttggatgg tcagttacga ttatgaaaga gcggagcata tctttgcgat gaacgggcaa 643381 acaggaaagg tcgttggaaa gccgccgatc agtcgaggaa aagtggctgc atggtttagc 643441 ggaatagcag gcgggacatt tcttgcgttg aagctcgtct cattgatgat gggaggcgga 643501 ttttgatgcg tggatttttt gggaaagcga tctttgttgt gctggctgtt ttcatcatga 643561 tgcctttact gggtatcgaa gcggtaagag cctctgaatt gcagcagcat gtgtacgatc 643621 gcgctcatct attgtcaaaa gcggagatcg gaaaacttga atctctctcg gcaaagctgg 643681 gtgcaaagag ggacactgat ttcatcatta ttacgaccaa aagcacaaac ggtgaagata 643741 ttgcagacta taccggcgat ttttatgatc gttacggaaa aggcagtaca gccattctga 643801 cgattgatat gacaaacaga gaagtgttta tcgcaggctt taaaaaagcc gaacagtatt 643861 tggacaacag caggctcaat agcatcagaa atacgatttc atctgattta tccaatgaaa 643921 attattttga agcttttgag acatatattc agctttccta taaagatatg ggcataaaac 643981 cgggagtaaa ccctgacaac atattcttta catggtggtt tcagctgatt gctgccatcg 644041 cagtcggggg aattgcggtt tcaatcatgc tttatcatgc aggcggcaaa gtaacggtta 644101 atggaagtac atatatggat cagcgtacgt ctgatgtgat tgatcaatac gacacttata 644161 ttagaacgac tgtaacaaga gaaagaaaac catcagataa agacagcggc agcgatggcg 644221 gtgttacgaa aggcggcacg tcatacagtg ggagccgggg cagtttttaa atgtaagaaa 644281 tagagaaagg gagaggcgta atgtcgtttt tcagaaatca attagcgaat gtagtagagt 644341 gggaagaatt tagagatgat atgatttttt ataaatggaa caatcgtgaa atcaaaaaag 644401 ggagccgttt aatcattcgt cccggacagg atgctgtctt tttgaacaat gggcgggttg 644461 aaggagtctt tcaagatgat ggcgattatg atattgaatc agaaattatt ccattccttt 644521 caacgttaaa gggctttaag tttggcttta acagcggcat gcgagctgag gtgctgtttg 644581 tcaatacgaa ggaatttacc gtaagatggg gaacaaaaca ggcgataaat attccggcag 644641 cgggaatgcc aggcgggatg cccattcgcg caaacggcac atttaatttc aaggtgcagg 644701 actatatcag cctgattgat aaaatcgctg gcgtgaaaga tcaatatttt gtagaggata 644761 ttaaaacccg tatcatttct attctggatc agcttctcat gaagtggatc acaagagaag 644821 ggaaagatat gtttaatctt caagcaaacg cttttgatat tgccaaggga attcaagagg 644881 acttagatat gcaattaata agcgacggga tgacggtcac tggttttcaa atcatgagct 644941 ttaattatcc tcaagaggtt caagatatga ttacaaagaa cgcttcctac ggtatggttg 645001 gggatgtgaa cagataccag caaatatcaa tgacggatgg aatggcatcc ggaaagatga 645061 gcggaagcgg agcggcttcg gatatggctg gaatgatgat gggaatgaat atggccaatc 645121 agatgatgaa ccaaatgaat cagaatcagc aggcacagtc atcaggccca cagtcaactg 645181 gcagcggaag caaaccgaat ttctgtccaa actgcggaac aaaaacgggc gaagccaatt 645241 tttgtccgaa ttgcggccag aagcttgtat aagaatcata cagtgaaaag tccggagtga 645301 tcagcactcg ggactttttt atttaggaga ataagcatta cctattgctt gctcctgaac 645361 aggccatttt cgagcccccg cttggataat tcccagcagc aattgacgac gttcctttat 645421 tgaattgacg gcaatttgaa atgtttgctt tgataaagcc ggtatgcctg attgttgaag 645481 ctttgagatg tctggttctg gcggcgcttg ttctgcagga tggatatagg cagtatgaac 645541 ggtatccaga tagtttttga tacttgagcg cgcttctttg atatgaagct gattcggctg 645601 atattgttca ggaattccgt atttgaaaat ggttagagcc tcatccaata cagcaacagc 645661 tataatggat gattcctgat gctgcgtgct gtggtaaaaa tgaaggatgg ggaaggcgtt 645721 atgctgagcg gtcagctttc ccagttctga tgaggcagcg acaagaagaa aatcaatgtc 645781 gtgaaaatct ttgccattcc atgcattatg gacgatttca gttccgtcat gccctagact 645841 taatacactt tgggcaaagg agcgtttttg attaaccgca ctcaagacgg aaatcaaata 645901 cgtgacagaa aatgtgatgg taagcagtcc ttgagctgtt tcaataatcg tgacaagctt 645961 ccataggcct ccgttcggag cgaggtcgcc atttcctaat gtaaacatga catagccgga 646021 aaaataaatt cggtctgacc aggaagccgg ttcttttgat tgagtttcca taagtgagtg 646081 agggtcactc gagtaaatca aaacccaccc gctccaaaat agactgatcc atatcactaa 646141 cgtcaggcat aacagcagag gaccagccat acttagaacc tttgcgtggt caccgctgat 646201 tttgcggcag cccttccaca gccaggcaga caggcatctt gtgatcgggc cggcaccgct 646261 ctctaaccat aacgtggtcc ataaaaaatc aatcatcccc gctgtcaata ataaaaggcc 646321 tgcaatgata taaccctcat tcattttggt tgcctccctt aagtcagcct tcttttattt 646381 tcttctctat ttccttttat cctgagtctg aaacaattga acgaatgttt gattttacag 646441 agaaaaatag gtgggagtta cccaacactt actcattttt caatatgaac agaaaatcac 646501 aagatttttg acttgattca cacattttca tgaagaaaaa cgttcatttt ccccttgaat 646561 tggtgatttt ccttttatag agtaaaaaat tttcagaaat ttatattgac tgaaagcgtt 646621 tttataatta tgataatatc agatataaca aaaatgtcac tataacatca ctacaattga 646681 actattaagt gactaataaa taccaaatga acgaggttat gcacaaagaa atgaccattg 646741 ttcttttaac gagaaatgaa atcgcttcca tagggattga catgctaaga agaagggaag 646801 gttatgaggt tattggataa aaacatgaac aactattttc tgaagcctgc ttacgaaatg 646861 tgaggaaggc agcagccctg gaataagttt ttgacatacg cattttgaaa aagactgggg 646921 gaaacagtat gaataaacaa ggaaatcaaa tgtcattttt acgtacaatt attttagtct 646981 ccactttcgg cgggcttctt tttggctatg ataccggtgt gctcaatgga gctttgccgt 647041 atatgggaga gccggatcag cttaatctca atgccttcac agaaggcctt gtcaccagtt 647101 cacttctttt tggagcggca ctgggtgctg tgtttggcgg caggatgtct gattttaacg 647161 gccgccgcaa aaatattttg ttcctcgctg ttatattttt tatttcaacg attgggtgta 647221 cgtttgcacc aaatgttacg gtcatgatta tttcccgttt tgtgctcggt attgcggttg 647281 ggggtgcatc cgtaacggtg cctgcctatt tagcagagat gtctcctgtg gaaagcaggg 647341 gacggatggt gacgcagaac gaattgatga ttgtatcagg acagcttttg gcctttgttt 647401 ttaatgcgat ccttggaaca acaatgggag acaactccca tgtgtggagg tttatgctgg 647461 tcattgcgtc acttccagcc ttgttcctgt ttttcggcat gatcagaatg cccgagagtc 647521 cccgttggct tgtttctaaa ggaagaaaag aagatgcttt gcgtgtattg aaaaaaatca 647581 gggacgaaaa acgggcagca gctgagctgc aagaaattga attcgctttc aaaaaagaag 647641 accagcttga aaaagcgaca tttaaagatc tttcagtccc atgggtgcgc cgtattgtgt 647701 ttattggatt agggattgcg attgtacagc aaattacagg tgtgaattcg attatgtatt 647761 atgggactga aattctaaga aattccggtt tccaaacgga agccgcttta atcggaaata 647821 ttgcgaatgg cgtgatttcg gtattggcaa cattcgtcgg aatctggctg ctgggaagag 647881 tggggcgccg gccgatgctg atgacaggct tgatcggtac gacaacagca ttattgctaa 647941 tcgggatatt ctcacttgta cttgaaggat caccggcact tccgtatgta gtcctgtcat 648001 taacggtcac atttcttgct tttcagcagg gcgccatttc accagtgact tggctgatgc 648061 tatctgaaat tttcccgctt cgccttcgcg gactgggaat gggtgttacg gtattctgtc 648121 tgtggatggt gaattttgca gtcagtttca cgtttccgat attgctggca gctatcgggc 648181 tgtccacaac gttctttatc ttcgttggat taggaatttg ctctgtcttg tttgtgaaga 648241 ggtttttgcc ggaaacgaaa gggctttcgc ttgagcagct ggaggaaaac ttccgcgctt 648301 atgatcacag cggggcaaag aaggattctg gggctgaagt gattggataa tttaaaaaag 648361 aatccgcacc cgagtgcgga ttctttttgg tttcaaatta gttaggtcta acaaggattt 648421 tgacttggct tttctcttta ataagagccc cgaagccttc ctcgatcaaa tcatctagta 648481 cgattttttt cgttacgagt ttgtcggctg agaaatagcc ttctttcatt aatgacaata 648541 cagccgggaa gatgtcgcgg tatccgataa ttccttttac tgtacgttct ttgattacga 648601 tatcgttcgg atggatttca gcaccttttt cccaaatgct gacgatgacg gtttcaccgg 648661 caattgtagt ggactggatg gcttgtcgta acaccactgg gacaccagtg acttcgaatg 648721 ctacgtcaac accgcctcct gtacgttctg caatctcagc gactacatcg tctgttttag 648781 acggatcaac gatgatcgcg ccaagctcct cagctttttg ctggcgttca ggagaaagct 648841 caacagcgta aatatcagtt gcaccggcag ccttcagcgc ttcaatgaca agaagtccga 648901 tcgggccgca gccgaataca gccgctttgt cgcctgcttt gagtttgctt gagcggacag 648961 cgtatagagc aactgcagaa ggttcaacga gcgcgccttg ttcatatgat aattcatcag 649021 gaagtttgaa caaaagctct tcatccacag agacgtattc agagaaaccg ccgcctccgc 649081 cggctaagcc gaggaatccc atttgttcat caaggttgta ggcgccttgg tggccgtgtg 649141 tagcaaaaat cggctcgact acaacgcggt ctccaacttt ataattttca acgccttctc 649201 cgacttcgac aacttcaccg gagaattcat gccccattgt gacaggtgcc gtttcatttg 649261 ttaatgggtg cggtttgtca accggaataa agatcgggcc gcccagatat tcgtgtaaat 649321 cacttccgca gatgccgcac catttgactt tgatctttac ttttcccggc tccgtttttg 649381 gctcttcgat atgttcaata cggatatcct tttggttatg ccatcttgct gccttcatgg 649441 attaccactc ctataacttt tgatgtgagt aattccgcac cggtcaatat gaactgttca 649501 caaaatcgcc atttttaaaa ccaaaaaaga aatgaaattt ttatataata taatctacgt 649561 ttttttgaaa aaaagaaact ttaaagaaaa aagggtctcg cacactcttt tttctttata 649621 tgagagtatc aatcgtttac atagctatga atttggtttg aacaatacgg taatggttcg 649681 ttcatattga atgcgacaac tactctatca ataattataa ctctaatact gctattataa 649741 taggataatc ttccatggtt tattttagca gaggtaactt ttttgacttt gtaacattac 649801 tgtaaggata ttgaaataaa aaatagctgg ttgatcgtgt ataatcttcc tagatgttaa 649861 caaacagggg gacgaaatgt tgaagaaagt cattttagcc gcttttatct tagtaggaag 649921 tactttggga gcttttagtt tttcatcaga tgccagtgcg aaacatgtga acggaaatat 649981 tacttggtat aatggagtcg ggaaaaaagg ctcttcaggt aagaaacttg gacattggga 650041 ttgtgcgacc aaaatcggat ttgatgttcc tagaaacggg acaaaaatca gagcttatgc 650101 aaaagcgaag cctaaaaagg tgattacggt ttataaaaat gatgttggca gaatgcctaa 650161 tgcagtgctg gatgttagcc ctaaagcgtt taaagcgctt ggatacccat taagcaaagg 650221 taaagtagcg gggcattaca gctattaatg tacatatata atctggaaag caagaagtca 650281 cattcttgct ttttctattg gtggagataa aagatgaaaa aaagaatcat attattatta 650341 gcagtgataa tagcggcagc tgccgcgggg gttgcgtttt atgttgcaaa ggataaaggc 650401 catgagaagg ctgctgatgt ttcagtcaat accgaaagcg gtgatgagct gctggtttca 650461 attacagata cggatctgct gacaaagtat tatgaaaatg acaaggtgat ccatgaggag 650521 aagctgacca gctatccggc atttgccttg gatcaaaaac agcaggtgct ctattatacg 650581 ggcaataatg aacagaatga aatgaggctt tttaaattgg atctgaagtc tcataaaaaa 650641 acgatgcttt ataaaggcgc ggagagtgcg gacagtttat ttttatcaaa ggaccgttca 650701 accatctatt tccgcttagg aaaagcggac gaaagcaatt ttcgaatcgc cgcttttgat 650761 ctgaagacga aaaagtataa aaatctttat cctgccgcta atgatcagga tgacaccgtc 650821 agcagcttct tttataacca aaaaaacgat tcatttgcat tgcttcatta ttctgtagaa 650881 gaagactaca agaaaacaga tgaagcaaac gaaaagggca tcgaccctga accgacaacg 650941 attcattttg cggaaggccg ccaaaataaa tttaatgagc tgaaaagcct gaaccaattt 651001 atcagcgata ttgctgtttc tgatgatgat aaacgtattt tattcacatc atatacgcaa 651061 aaaggaacgg agcaaaccgc ttctattcaa atgctcaatg cggatacgaa aaaatatgaa 651121 agcatcatct caaatcaaaa atcatttaag ctgttaattg acgcacagcc tcagttttct 651181 aaggatggga agaacattta ttttcttgcc gaagccaagg gggctaaaaa gctgaaggac 651241 gaaacagggc gtgaagctaa ggtgcggacg atttattcct atagccttga gaataagacc 651301 ttcaaaaaag tatgggaaaa tccgaacggc atcatcaaca gcttttttgt gattaactaa 651361 taaaaaccac tcggcatgag ctgagtggct tttttaatgg atgaggtgca gggctaatga 651421 tccgagccat ttaaagatat gaatcagagg taccgacaaa aacagaagtt caacatatga 651481 gttcattgca acattcagct ttttgaacgc agctcttttt ttcaagtctt tttgctgctg 651541 gtttgagatc acgttatcac tcctcttata tccatattat accattaaaa cagacaaaaa 651601 agccctaaac gtttacagtt ttgggcttct ttcttcgtat ttggcctctt gcaatgagag 651661 gcttttattc tgaaatatag aattttgtct ccgttcgggg tttgtttgct tgcgggagac 651721 tgcatttgtt atagggaaga actagcttgt tttcgtttgg ctgttgtttt ggagattcac 651781 taatgaacgg atgccgtcga ccattttact tccgcacaaa gggcacaatg gcgtatcact 651841 gctggcgaag ttttttcggg tccagccatt acagtcttct tttgtgcatt cccaagtact 651901 cacatcttcc tttggcagcg gttcttgatt tcgtttgtta tagtaagaca taaagtcact 651961 tcttccctca tgtattttac tgcacatttc ctattgtctc atacttttcc ctaatctcct 652021 aattcctttt tctttatgac tttccaataa ccccatctaa aaaggagagg agtgtgctgt 652081 taaaagcatc tggctcttct aaaaacgggc aatggctgct tttaggaaag gtaacgagtg 652141 tcgcgtttgg aatattgctg cgcaagtgtt ccccagctgc tgtagagaaa aatttcttgt 652201 cttccccgaa gcacagcaat gccggcacat tgatgttttg gagggtgccc cggtaatcag 652261 cggccgtttg gttaaataaa atcgtgctag aaatggcagc cggctgtttg aggatttctg 652321 ccagcatcca ttctgtttcg gtctcggcag gcggttctgc gaacatattc tggatgaagc 652381 tttcgtagaa aggcagcggg tcagtttgaa tggcgtgcat cgctgttttt aagccgtcaa 652441 aatcaaatgg accatgttcc cagccctccc attgatagtc cgaagcggat tgatcgatga 652501 tcacagcggc ttgaatgtta tcattcccaa actgattgag ataatcccat acgacaaaag 652561 cacccattga ccagccggca agaacgacat gatcaagctc cattgcattt agaaattccc 652621 ttatgtcacg ggcatattgg gaaatggtgt ggccgtgaag cactttgtca gattcgccgt 652681 gtcctctaag atcaagacga atacattgat aattggcaga aagcaccgaa aattgtttgt 652741 ggaaaaattg tccgctcatc agcaccccat gtataaacag gatcggcgtc ccgctcccgt 652801 gtgtttcata gtaaaggcgt gtctgatctt ctaatatgat gtatggcatg tttctcctcc 652861 tttagtttcc atcatgagta tggctggctg ctgttgagct gatgatggca gctgtcgcgg 652921 ctgcctgctg cgcttgaatg actgtttcga tagcggtgta tagtcctgat tccatcagca 652981 gatttttctc catatgctca ctgagataga ggctgacagc aattttaaag ttcatttcct 653041 tttgccattt aaaagctttt tcctggttta attcgtcagt gatgcacaaa acggttttga 653101 tatctggctc ttccagaaat gtgaggagag caaggtctgg ataatgataa tcctttgttt 653161 ttttgacaga ttcagtgatc gattgatata tctgtttgca agcggaaaca agcatttcgg 653221 gctctttttc actttgcaag gccagaatat ggctgacctg atgtaagtac tgtccttttt 653281 taaagccgtt ggctgccagc agttgatagc atgtttccgc cttctgtagc gcctgcaaac 653341 cttttccgtt ttctccaagc agtacggcaa gcggaacatt ctgagttgaa gtgaggaaat 653401 aatgattttt cttcatctgc tgataaacag ctagccccat gttcatctgt tctttttggt 653461 ttgtcgtttc agatttgccg gtgagcaaga tcagagcgga aaggtatgtg aacatatccc 653521 gcttataccc tagcttcacc atttcattgt atacatcgat gaaagtctga aatgtttgtt 653581 ttgcctcatg ctgaaaatga atgtccagaa tagatgcaac agtaaagcgg tggtgtgaat 653641 tgagtgttga gaagctgccg atgtttgatt tgatatagct gctcaaatca taaaagcgct 653701 gaaaatcaaa ctctctttta ttcacaatat atgcagaaga aatgagcatt aatatctgat 653761 cgtgtgaaac tttccatttt aattttgttt ttaattcagc ataaatggaa atgtaatgct 653821 ttgttttttc atgtagatcg tgtgtgagca taaaaagcag ctccttttgt tgtttttacg 653881 taatacgata aatagggcca aaggtttcat aaagaaaaaa cttgcctgct agaggcaagt 653941 ttgtcgggtt atttatgggg atcagttata tccatcggtc tcatcatgtc atagtcttca 654001 tgctctagaa tatggcaatg ccatacgtat cgtccgctgt acggaccgaa tgtcgccgcg 654061 attctcagga cttcacctgc atgcgcttga atggtgtctt tccagccctt ttcacttggc 654121 ggcggcggga cagccggacc ggtataggac aattccccgc tttcttgata acgggcgata 654181 tcaaacggcc gccggtctaa tacacggaag gagactagat gcaggtggat cggatgtgtt 654241 ccgcgtgtcg ggttgataat ggaccatatt tcagttgtgc cgacttttgg tgtttctgtg 654301 acgggatcgt gccagcgttt gttattaagc agaaggacgg gtctgccgta ttcgtcctgg 654361 gtgcctgcca gttttaacgt tctgatgttt tgtattcttt catgctgtac cgaagggtat 654421 gaggcgaggt acttcggctt tctgctttcg tctttttgtg ccaatggttt tgtgactctg 654481 aattgcatga tattcgcatc tgtttcagga ttgacgtcac cgccgcagcc cgcgctgttt 654541 gccaaaatga tcgattctcc ttcatatgct gtgaagtcaa tgatgatatc gtaacgttca 654601 gcaggcgcaa ggctgaaaga attcagttta acagatcgcg gcaggagccc tccatctgaa 654661 ccaatctgaa taaaatctcc gccattatcg agtgacaggt tataggttct tgtattggag 654721 gcgttgatga cacggaatcg gtatttcctt ggctcgactt ccaagtatgg ccataccttc 654781 ccgttgacga gtatggtttc tccgcaaaaa gccggaacga ttgaaggatt aggcagtgac 654841 ggagaagggt tttccggtgc gctcggataa aacaaagaac catcctcatt gatcgtgcgg 654901 tctgtgataa gaagcggcac atcgtattcg tctgaaggca gttttaagcg tttttccttt 654961 gggtcatgaa tgatatatgc accgacaagt ccggcataga catttagcct ggtgagcgcc 655021 atggcgtgat cgtgatacca caatatagcc ccgcgctgct ggtttggata atgataaacc 655081 tctcttttga aataaggtcc tgtttgttca aagtctttgg aaaaccaagc ctccggatac 655141 ccgtcactat catctggcgt gacgccgccg tgtaaatgaa caacagtctt tacctcgggc 655201 tcttcatgct ggctgtcact gtgatgaatg gtgtgatcaa tcggaaggaa atgcgtggaa 655261 ggaaggttat tcatccattt tacatatacg ttttcatttc ttttaacctc aatggtcggt 655321 cccggaaata agccgttgta gccccacagg cgggttggag ggagatcgcg atggagctga 655381 tgagtgcatt cctccatggt gacttcgtag tatgtttttt cttttgattg ctgtactggc 655441 tttagtgtat ctgggattgg gagagcatcc acaaattttt caagtgtcat tttcatctgt 655501 ccttatctaa attttccaaa ttggtactat agttaatgac aataaggacg tgatggttac 655561 aaaaaatctt cgtgctgcag cccgcccgaa gaagaaaata acaaaatcct aaacggcagg 655621 ccgtttagga tttgatcagc attaaggcag gatatcgggt tgctgctgtg tgactgggtt 655681 ggcagccgct ttctcgctca ccttgcgttt tctgaacaca aggtaagaaa tcagaacgat 655741 tcccgtgatg acgcctgtca gcagcagctc gtctctcatg gaatcaataa acgccatgga 655801 cactaaaatt ccgcaaatgg cgatgatggt caagtaggtt aggaaaggga agagccacat 655861 tttgatcttc aatgcttctg ggtttgtttt ttcgagtttt ttccgcattt tcagctggga 655921 aacggcgatg acaagataga cgagtaaagc gattgcgcct gatgagttga ctaagaataa 655981 aaagacggta tccggtgaaa aatagttcat tacgaccgcg atataagaga aaaatgtccc 656041 ggccacaatg gcttgtacgg gaacgccttt tttgctcaat ttcataaaac ggcgcggcgc 656101 ttcatttctt tctgcaagtg aatacagcat tctggatgtg gtatacaaac ctgaattcag 656161 gcaagagagt acggctgtga ggacgataaa gttcataatc tgtgcggctg cgggcactcc 656221 tatatgctca agtacagcga cgaaagggct ttctaaaata tttgctgaat tccatggcaa 656281 cagcgccacg acaatggcga ttgagcccac gtaaaagacg atgatgcgcc atacaacgga 656341 tctggtggct tttgtcacag attcgatcgg gttggatgtt tcccctgctg caatggcaac 656401 gatttcagtt cccataaaag agaagatgac aacgacaatg ccgagcaata cggagctgat 656461 gccctccggg aaaaatccgc ctttgcctgt aagattcgaa aaaccgactg gctcactgcc 656521 cggtgcaaag ccaaaaataa aggcaaaacc aacgattaga aaagcaatga tagtcacaac 656581 tttaatgagg gagaaccaat attcaaactc accgaaagac ttaacggagt agacgtttgt 656641 cagggtgagc acaatggtca agatcaaact tgtcagccac agcggaatat catggaacca 656701 gtattgaata atgccagcac cggcaatggc ttcgatcgct atgacgatca cccagaaaaa 656761 ccagtacagc cagccgattg taaatcctgc ccacggtccg atggcgtcgt gagcgtattg 656821 agaaaacgat ccgctcgtcg ggtttacggc agacatctca ccgagcattc tcataataaa 656881 aatcaccaat aatccggcta acgcgtaaga aacaacggca cccggaccgg tcgagtgaat 656941 cactgaaccg ctgcctacaa ataggccggc tccgattaca ccggcaatcg aaatcattgt 657001 catatggcgg gtctttaatt ccttttttaa tcctgattga gactggttca taagttacct 657061 ccttttaaaa tgcaatcatt actgaatatt atgataattg aaactctatc ataaatatac 657121 agtttgtcga aaattcgtgt aagaaaatat accagcttat ttcaaatttg tagtgttttg 657181 tttgcgcttt cagcgaatgt gtggaaaaaa tgtttcgttt tttattcgct gtgtgatttt 657241 gcgtaatatt tacaattcga tagaatgcga gaagcactgg tgtccttggg tttgatggga 657301 tttttggcgg agcaaataaa ttggatgaga gaaaaagtgt tccttcgtca ctatttttct 657361 gtggcgggtg aatcatgttt ctgtagaccc actgcggatc agctttgtaa gataataata 657421 ggaaaatgtg agcgagagga ggttttgtat ggagagatat gatgaactga aaaagggaga 657481 atccggagcg ctggtcagca ttgccgcgta tctagttctt tccgcaatta aactgatcat 657541 cggttatctt tttcactcgg aagcacttac ggcagacggg ttaaataaca caactgacat 657601 tattgcttct gttgctgtgc tgattggcct gcgcatctct caaaagcctc ctgacgaaga 657661 tcatccatac ggccactttc gagcggaaac gattgcatcg cttatcgcat cgtttattat 657721 gatggttgtc ggactgcaag tgctgttcag cgccggagaa tctatttttt ctgctaaaca 657781 agagacgcca gatatgattg cggcttggac ggcagcgggc ggggcagtcc tgatgctgat 657841 cgtttaccgg tacaataaaa ggctggccaa aaaggtgaag agccaggcgc tccttgctgc 657901 ggctgctgat aataaatcag acgcattcgt cagtatcggc acatttatcg gcattgtggc 657961 tgctcaattc catcttgctt ggattgatac ggtcactgcg tttgtgatcg gtctgcttat 658021 ttgcaagacc gcatgggata tctttaaaga gtcatctcac tctttgacag atggattcga 658081 cataaaggac atttccgctt ataaacagac aatcgaaaaa atctccggtg tgagccgttt 658141 aaaagacata aaagcaagat acttgggcag tacggttcat gttgatgtgg tggttgaggt 658201 atcggcagat ttaaatatta cggaaagcca cgatatagcc aatgaaattg agcggagaat 658261 gaaggaggag catgcgattg attattcgca tgttcatatg gagcctttag aacaaaaata 658321 atggagcttc ctgtcacagg aagcttcagc gtgtcgacaa accctcgcat tcgttgtcag 658381 gtctgcgctt cggtgctcac gaattagaac attcgctccg ctcctatgct cgtccttcct 658441 agacttcaag ggttttcaat cacgctgaaa agatgacaaa accctaaaat gaaagccatt 658501 ttaggatttt gtcaacaatc tggagcttcc tgccacagga agcttttttg tgtgttttgg 658561 ccagctttat tggtaacaat ttgctagaat cgttttttta tacagattgc tttttgtggt 658621 aaagttaggt tacattatga tgaattttgt agatgactag gaggaaaata atggcatatc 658681 aagaagacct gcatcctttg ctggggaaag cagttgaaca tattaataga gtaatggttg 658741 gaaaacgaga catcgccata ctcagcttag cagcccttct tgccaaaggg catgtgctgc 658801 ttgaggatgt acccggagtc ggaaaaacga tgatggtccg cgcgctggca aagtcaatcg 658861 gcgccgattt caaaagaatc caattcactc cggatttgct gccatctgat gtaacagggg 658921 tatctatcta taatgcgaaa acgatggaat ttgaatatcg tcccggccca attatgggaa 658981 atatcgtgct ggcagatgaa atcaaccgta cctctccgaa gacacagtcg gctttgctcg 659041 aagcgatgga agaggggagc gtcacggtag atggccatac gatgcagctt gccgatccgt 659101 tttttgtgat ggcaacgcaa aacccggtcg aatatgaagg gacctatcct ttgccggaag 659161 ctcagcttga ccgtttttta ttcaaacttc ggatgggtta tccgtccttt aatgaagagc 659221 ttgacgtctt atctcttcag gaaaaaagcc atccgattga gacgcttgag ccggttattg 659281 caaaagaaga cttcatcttt ttacagaggg aagtgcaaaa tgtccgtgct gatgacagca 659341 ttaaggaata tatcgttgaa attgtgcaga aaacgagaca gcatccttct gttcaattag 659401 gcgtcagtcc gcgcggctca atcgccctca tgaaagcggc acaggcatac gcgctgctgc 659461 atcatcgcga ctatgtcata ccggatgata ttcaatattt agctcctttc acgctgccgc 659521 accggatgat gcttcatcct gaggcaaaat ttgaagggat tcaggcagaa gcgatcgtaa 659581 gggagatcat gtcagctgtg aaggtgccgg ttcaaaggtc ggcggtccgc tgatgaataa 659641 gaaatggcaa tggctcgtat atggttggaa gctgattata ttaactttat tgacggctgc 659701 tgttttttct tatgcgatgt ttcagggcgg ctttgtcagc tggtttttgt tttacgcgtt 659761 tctccctttt gtcttgtatg ccgggctgtt ggccttgtat ccgctccgtt cttttcaggc 659821 ttcaaggcaa atggataaaa cacaattgca tgcgggggac aggctgggcg taacggttac 659881 gctgagaaga aagctgccat ttccgctgat gtatatggtg attgaagatt gcctgccaga 659941 aggtatcgag tcattaaatc gagacggagc cgcggccaaa cggctcgttt ttccttggtt 660001 taaacggagc atgacgatgt cgtatgaatt agctcgggta ccgcgcggag agcatcactt 660061 tcattctgtc agggtgcgaa ccggggatgt tcttggcttg attgaaaaaa cagcattttt 660121 tgagctggat gataccttgt ttgtttatcc attctatcag cgtttttcct atcaggtgaa 660181 tgagaggcat caggaagacg gtgtaagcgg ttcttctcct attcatcagc accattcctc 660241 agtcgcagca agtgtgcgga attatcagcc gggagaccgg tttgctgcgt tagattggaa 660301 gacatctgca cggcggagcc agctgatgac gaaggaattt gagccttctc gcagcaaaaa 660361 tctgtttctg ctgatggacc gtttttcctc agacgcattc gaagaggtcg tttcagtgac 660421 agcttcgatt cttcattctg ttttaaaaaa cggcgcgggt gctggtctgg cttccatcgg 660481 gaaggaaaaa aacattttcc ctattcagga aggggatcag cattttaagc acatgcttcg 660541 gcatttagcc atcgctcatt gtgatgcggc agacccgata agccgatatg cacgggaaga 660601 gctgggaaag ccatctgttc gccaagctga tcaagttgtt gtcacgggac agttaacgga 660661 agatatgctg cacctcgcag aaataggagg cggccgggtt acggtgatac tggcaaaaga 660721 gaaagatgct gagctctctc aagctgaaaa tgtcatgatt gaacgcatga tgaaacgcca 660781 aatcagagtt cggatcatga ggggcgggcg agtttcgcgt gttgtttaga aagagaggtg 660841 actggttcac atgccgcacg atgatcacaa gggaagccgt ttgagcttgc tgttatttta 660901 ttttctggct tttttattgc tgtgggagtg gcttaggccg cttgacagtt ttactgaaac 660961 gaaacataca ggctttttta gtgtctttat cggcttgacg tttctgctga cttttttcag 661021 gatgaggtgg tttgtcaccg ttcctttttg tgtcatattt acattgatct cgatacacat 661081 cctgttttat caaggatcta tattcgactt gagctgggtc agctcttttt tgcaggatgt 661141 ctatctgaat atcacgctga ttcaatcagg gcaatggaat gacatgattc cttcatttcg 661201 gaccctgctg ttttttgtgc tgctgtggct gctggtctat ctcctgcatt attgggtgat 661261 ttaccagaga agaattttgt ttttcttttt gatgacagta gcgtatatta cgattcttga 661321 tacctttacg ccatatgatg ccacttttgc cgtaatccgt atcgtgctga tcggcttctt 661381 tatgctgggc cttttatact tggaacgcat taagctgatg gaaagaatca cactgccaaa 661441 aacatctgtc ctgaaatggt ttcttccttt atctgtattg gttttggctg caacgggatt 661501 cggactcgcc gctccaaaat cagagccggc ttggcctgat ccggtgcctt ttcttaaaaa 661561 aatcactcat caagaccgcg tgtctgcagg ggaaagcaaa atcggatacg ggaatcatga 661621 tgaatcactc ggcggcccgt tccagcagga tgctacacct gtttttacat ggcagggaaa 661681 agagcgtacg tatttccgtg tggaaacgaa ggacacgtat accggaaaag gctggattga 661741 aacagacaca ggcatgtcgt atcagcttag caatggaaaa gttgaaaatc tgtggtttga 661801 ccataaggtt gcgacagagc gccgcaccgt ccgtgtaaaa gtcgataagc actacgggta 661861 taaccatctg atgtatccga ttggtgcgga aaccattcag ccaaagcagg ctgtctcact 661921 tgaaatgaac ggcaacacgg agcaaatttc tccgatcagt gaacaagccg gtgaaatcag 661981 aaatatgggg aattatacag taacgtacaa ttccccggtc tataagctgg atgaactgag 662041 aaaggtaaaa gtgagaaaaa acagtgagga gtacacattc agcgatcgct acatgcagct 662101 tccagattca ctgccagagc gggtgagaac ccttgcgatc aaactgactc aggatcacga 662161 caatatgttt gataaggtga aagcggttga ggactattta gggtcaaatg cgttcacata 662221 tgaaacagaa aacgtgacca ttccgaagaa tgatgaagat tatgtcgatc aatttctctt 662281 tgaaacgaaa atgggttatt gtgataactt ttcttccgcc atggtggtgc tcttgcgctc 662341 ggccggcatt ccggcccgct gggtaaaggg ttatacgtcc ggcgaataca aagaagcagg 662401 gaacaaaaat ggcagcattt acgaagtgac aaataacaat gcccattcct gggtagaggt 662461 gtatttcccg gaacagggct gggttacatt tgagccgact aaagggttta caaatccggc 662521 tcaatttaca tcttctgaca caaaagactc tggcagcgat agcagcagct cgccgaagaa 662581 agcaaaagag aaacagaaag aagagaaaaa acagccgcaa aaagaggaaa aacaaaagga 662641 aaagcgggag ccagctgttt ctaaaaagcc gtccgcttcg catactaatg ccggtgcggg 662701 cttgtatgca gcgcttgcgg ttcttgcagt cctcctggtg gcagctgtat tgctgtatgt 662761 tttccgctcg ttatggattc ctgttttcgc cgtgaggaaa ttgaagcggc gcagtgatca 662821 gcacgcgttt tttgaggcat atggcgcgct gctgaaacaa ctgaagagaa aaggactgcc 662881 gaaacgagac agtgaaacgc tgcgtgatta tgcaaaacga attgatgaaa aatacgacat 662941 agaagacatg tcaaagctga cattaagcta tgaaagggcg ctttacagaa atgaagattc 663001 ttcggcgcta tggaatgatt cgagagagtt atgggaaaat ttaattaaaa gaagatggtc 663061 ttgaccgctt atcgacgtgt tgttagaatt agtgaatatt atcggagtct gggagcgagt 663121 tggcctgact ccggcaaacg gccttgccaa agagggcgga gcgagcttca tatctgtcct 663181 cgtttttttc tgtgtcaaaa aacttagagg agattaggtg acaaccatga caaagttagt 663241 gaatgaaatg attcttgtcc ttgatttcgg cagtcagtat aaccagctga ttacacgccg 663301 tatccgtgaa ttcggtgttt acagcgagct gcatccacat acattgacgg ctgaagaaat 663361 taaaaaaatg aatccaaaag gaattatttt atccggcggt ccaaacagtg tgtatgatga 663421 aaactctttc cgctgtgacg agaaaatctt cgagcttgat attcctgttt tgggaatttg 663481 ctacggcatg cagctgatga ctcattacct tggcggtaaa gttgaagcgg caagccagcg 663541 tgaatacgga aaagcaaaca tccgcatcga aggcacacct gatttgttca gagatcttcc 663601 gaatgaacaa gtggtttgga tgagccacgg cgatttggtt gtagaagttc ctgaaggctt 663661 cactgttgac gcgacaagcc atcactgccc gaactcagca atgagcaaag cggacaaaaa 663721 atggtatggc gttcagttcc acccggaagt gcgccactct gaatacggca atgatcttct 663781 gaaaaacttt gtattcggtg tttgcgaatg cgaaggcgaa tggtcaatgg agaactttat 663841 cgaaatcgaa atgcaaaaaa tccgtgaaac ggtcggagac aaacaggttc tttgcgcgct 663901 aagcggcggc gttgattcct ctgttgttgc tgttttgatt cataaagcga tcggcgacca 663961 gctgacttgt atctttgtag accatggtct tctccgtaaa ggcgaagctg agggtgttat 664021 gaaaacattc agcgaaggct ttaacatgaa tgtgattaaa gtagacgcaa aagatcgatt 664081 cttaaacaaa ctaaaaggcg tttctgatcc tgagcaaaaa cgcaaaatca tcggtaatga 664141 attcatttac gtgtttgatg atgaagcgga caagctcaaa ggcatcgact accttgcaca 664201 aggtacgctt tacacagata tcatcgagag cggtacagca acggcgcaaa cgatcaaatc 664261 tcaccacaat gtcggcggac ttcctgaaga catgcagttt gagctgatcg agccgttaaa 664321 tacgctcttc aaagacgaag tgcgcgcgct tggcacagag ctcggcattc cggatgaaat 664381 cgtatggcgt cagccgttcc caggaccggg actcggaatc cgcgttcttg gcgaagtaac 664441 agaagaaaaa cttgaaatcg ttcgtgaatc agatgcaatc ttgcgtgaag aaattgcaaa 664501 tcacggctta gagcgtgata tctggcaata cttcactgtt cttcctgaca tccgcagcgt 664561 tggtgttatg ggtgacgcaa gaacatatga ttacacaatc ggaatccgcg ccgttacatc 664621 aatcgacggc atgacatctg actgggcgcg tatcccgtgg gatgtgcttg aagtcatttc 664681 gacacgtatc gtaaacgaag tgaagcacat taaccgcgtg gtgtatgata ttacaagtaa 664741 gccgcctgcg acgattgagt gggaataaga atcaattaat ggaaaccatc tttttggcaa 664801 ttttgccggg aagatggttt tatttgttta ttacgaacaa aatccgattt tgcgcgacta 664861 ttgttcgctt tttgtattgt tttttcaaaa tgaacttggt acaatagaca cagaaatcaa 664921 ataagatgaa ttcgtataat cgcgggaata tggctcgcaa gtctctacca agctaccgta 664981 aatggcttga ctacgtaaac atttctttcg tttgatataa ataaaacacg gttatttatt 665041 caaactgaaa tccgtctgta gtcaagcgtc ccaaaatgta ttgggacgtt ttttatttgg 665101 cgttttcagg acagaataaa tagcaaagag tgaagggagt caaatagctt gaaaacgttt 665161 tttcagtttg atgagctggg caccagctat cgcaatgaaa tcattggcgg attaacgact 665221 tttttatcta tggcatatat tttgttcgtc aatccgatta cgcttgcttt ggagagcgtg 665281 aaagattttc cggaggcgct gagaattgac cagggtgcgg tctttacggc gacagcgctg 665341 gcgtctgcag caggctgtat cttaatggga ttaatagcga gatatccgat tgccatcgcg 665401 ccgggtatgg ggctgaacgc gttttttgcg ttttctgttg tccttggtat gggtatttca 665461 tggcaggcag ctttgtccgg tgtttttatt tcaggtctta ttttcgttgc tctttcttta 665521 acaggttttc gtgaaaaaat catcaacgcc attccgcctg agctgaaatt ggcagtcggt 665581 gcggggatcg gcctgtttat tacatttgtt ggattacaag gttcaggaat cattacagcg 665641 aatccttcta cgctcgtcac gatcggaaac attcacagcg gtcctgtgct gttaacgatt 665701 ttcggtgtga ttgtcacggt tattttaatg gtgcttcgcg tgaacgcagg cgtgtttatc 665761 gggatgctat taacagcggt agccggcatg attttcggtt tggttccggt tccgactcaa 665821 attatcggca gtgtgccaag ccttgcgccg actttcggac aagcgtggat tcacctcccg 665881 gatattttct ctgtacaaat gctgatcgtt attttaacat tcttgtttgt cggatttttt 665941 gatacagctg gtacacttgt tgctgtggca acacaagctg gtttaatgaa ggaaaacaaa 666001 ttgccgcgtg cgggccgtgc gcttttagct gattcatctt ctattgtgat cggtgccgtg 666061 cttggtacgt ctacaacaac ttcttacgtg gaatcaagct caggtgtcgc tgcgggtgcc 666121 cggtcaggat ttgccgcaat tgtaacaggg attctctttt tactggctac gtttttctcg 666181 ccgctcctat cagtcgttac gtcaaatgta acagcgccgg cgcttattat tgttggtgca 666241 ttgatggtgg cgccgcttgg caaaatcgct tgggataagt tcgaagtggc cgttcctgct 666301 ttccttacca tgatcatgat gccgttaacg tacagcatcg cgactggtat tgccatcgga 666361 tttattttct atccgattac aatggtgtgc aaaggaaaag caaaagaggt tcatccaatc 666421 atgtacgggc tgtttgtcgt atttatcctg tactttatct tcttaaaata aggaatgaaa 666481 aaccagctgc actggcagct ggtttttttg ttgcaaaaga taaaaccatt tcatacgata 666541 taccgtcatg tagatgtgcc gccatgcttt acttaaatgg aaatgacttg actgttcagg 666601 aaggcttcgg taccttatat aagtgtttta ttttcttgct gaatggtatt ccgccgtatt 666661 tttttgatag gagttgctga catgacggaa gaaagaaaag aaacgtttga agaagaaatt 666721 aaccagagtg aaagaataga tgcagatgaa gaaccgctat cgagaatgtc cagaaaggcg 666781 agccggcaaa gcaagcagaa gcaaaaacaa aagcagaaac cgcgccagga acgcggtgaa 666841 tcaactgtta aagacaagct tgcgtctgtt tgggcagcca tcaacagata ttgcggtttt 666901 gcgttctcga ttttaaaatc tccggcgaaa actgtcgtaa cggatggttt ttctcattat 666961 aagtacggtc tgatttcaat gcttatattc agtatcattt tttcaattgg gaattggttt 667021 cagttaaagg caagctggaa tcggccgctc ggtttcggag aacgccatca tgctttctat 667081 gacgggtttt tagttgttct tgtgtatttg ctgatctttt tcgcggtaat ggtctttgct 667141 atatgggctg tctcccgcta tatgatgaag cagaaggtga cgttcagaga agcggctgcc 667201 gtattgggtt cattgcttgt acccgtaatt gctgtttcaa tcctttggct gatctttgcg 667261 atcgtaaata tcccaatgct gacagtactg tttacggtgc tgatcttgtt ttccatcttt 667321 tttatcatcg cgctgtatgt acagcgtgtg taccaggcgg cacaagatgc accaattgat 667381 tatatctatt gtgtatttgc agtagttgcg atagcgctgc tgtttacggc agtgacttgg 667441 ccgtttattt ctgaatatat tacggcgtcg ttgattccgc tttaatgaaa aaaccggcta 667501 atcctagccg gtttttttat gtcacacttt ttacaaatat atctaaaaaa catagttgat 667561 ttgtaggatt aacccgtgta tgatggggaa aatgctgaaa acgtccagcg caaaaacctt 667621 tatgtttaag gaggatgatg gacatggctg atgtacttcg ccgagcaatt aaccaaaaga 667681 agcaattttt aaaaaccaaa ttactgctct cggaatttta tcaaggaaga ggggaacagc 667741 ttgctgacta cacgctgagt gagcttgaga aagaatacaa gtcccttcag aaaatgaaaa 667801 aagagatctg acaatagata taaagaggtg agtctgctga aaagcgggct tttttgtttt 667861 gattttgaaa aggcgagaaa gagggtaaac tactactgtt caacacataa aagcgtgtcg 667921 aaatattttg cttaagctta cgggcgaagc tgattgtaaa cggctcattt ctctagtaga 667981 atatgaatgc tttgtgcaag ctgaagagta gggggatgaa taaaatgatg caaaccatct 668041 tatcaaatgg gatagccatg gttctcataa ttctcattat taatattgtc tatgtgtcat 668101 tttttacgat aagaatgatt ttaacgctga aaggacagcg ttatttagcg gccggcatca 668161 gtacgattga aatactggtt tatgtgacag gactgagtct ggtgctcgat aacttagacc 668221 agattcaaaa tgtgatcgcg tacgcgctcg gttacggtct tggcgtaatt gtcggcatga 668281 aaatagaaga aaaattggcg cttggctata ttatggtcaa tgtgattacg aaggagctcg 668341 atcttgatct tccgaagcag ctccgtgaaa aaggctacgg cgtgacaaac tgggtggcag 668401 gcgggcttga aggcgaccgc acagcccttc agatcctgac gccgagaaga tatgaactcc 668461 agctatatga tacgattaaa acacttgatt caaaagcctt tattattgcg tacgaaccaa 668521 aaacaatcca cggcggcttc tgggtcaaag cggtgaagaa gaggagaatt aaagaataat 668581 ggcaaagccg aagaagaaaa agtttgaagt gacagagcag caaacgattg atgcggtgct 668641 tcagcaaatg aaagaagaag gatatctgcc tgtaaggcga atggaagagc ctatttttat 668701 ggaaaaaaag gaaaatgggt caattcagat cgttccgtgc gggaaaaaaa tcgtatttga 668761 agggaaattg atctaaaaca cgaacattag tagaatgaat ttttgtatcg ttcgataata 668821 tcgttgacat tatccatgtc cgttgttaag ataaacatga aatcaaaaca cgacctcata 668881 taatcttggg aatatggccc ataagtttct acccggcaac cgtaaattgc cggactatgc 668941 aggaaagtga tcgataaaac tgacatggat atatcgcaga agcgaacgac tgacgataca 669001 tgtaccatgc ccggtttgta ttgcttcctc ataagtgcaa tgcagagcgg gtatttttta 669061 ttttctgaaa acaaaagcat tagaaggtgg ggaacagaat gcagccgcta gtaggaatca 669121 tcatgggaag cacttccgat tgggagacaa tgaaacacgc atgcgacata cttgacgaac 669181 tcaatgttcc gtacgaaaaa aaggtcgttt ccgctcaccg gacgcctgat ttcatgtttg 669241 aatatgctga aactgctaga gaaagaggca tcaaggtgat tattgccggt gccggaggag 669301 cggcgcatct gccagggatg acggctgcga aaacaacact gccagtcatt ggagttccgg 669361 ttcagtccaa ggcgctgaac ggaatggatt cacttctttc catcgtccaa atgcctggag 669421 gcgtgcctgt tgcgacaaca tccatcggca aagcgggtgc tgtgaacgca ggcctgttag 669481 cggcgcaaat tttgtcagca tttgacgaag accttgcccg taagctggat gagagaagag 669541 aaaatacaaa acagacagtg ttagaaagca gtgatcagct tgtctaaaca aatcatctat 669601 ccgggagctg taatcggcat tatcggcggc ggccagcttg ggaaaatgat ggctgtgtcc 669661 gccaaacaaa tggggtataa agtcgcggtc gttgatccgg tgaaagattc gccgtgcggg 669721 caggttgcgg atgtcgaaat taccgctcat tataatgacc gtgaagcgat tcgaaaattg 669781 gctgaaatca gcgatatcat cacatatgag tttgaaaaca tcgactatga tgcgctgcat 669841 tggctaaaag atcatgcgta tctcccgcaa ggaagtgagc tgctgcttat tacccaaaac 669901 cgtgaaacag agaaaaaagc aattcaatcc gcgggctgtg aagtcgcacc gtacagcatc 669961 gtcaaaacaa agaatgaatt gaaacaggca gtacaggagc tcaggcttcc ggcagtgctg 670021 aaaacatgcc gcggcgggta cgacggcaaa ggccaatttg tgataaaaga agaggcgcaa 670081 atggagcagg cagccgctct gttagaacac ggaacttgca ttcttgaaag ctgggtttct 670141 tttaaaatgg aactgtcggt gatcgtcgtt agatcggtaa acggtgaaat ttcaacattt 670201 ccgacagctg aaaacattca ccacaacaat attcttttcc aaagcatcgt gcccgcacgg 670261 gtagagaaag ggattcagca gaaggctgct gatctcgcag ttaagcttgc agatgagctt 670321 aaccttgtcg gaccgcttgc tgttgagatg ttcctgacag aggacggaga gcttttggtc 670381 aatgaactgg cgccaagacc gcacaattca gggcattata cgctggacct ttgcgagacg 670441 agccagtttg agcagcatat cagagcggta tgcgggcttc cgcttgggaa gacagatttg 670501 ctgaagccgg gcatgatggt gaatcttctc ggcgatgaag tgaagcttgt tgaggaagac 670561 ccggagcttt taaaagaggc aaagctatat atatacggaa aacatgaaat caaaaaaggc 670621 cgcaaaatgg ggcatattac atttatgaag cagcctgaag acgaatggat tcaggagatc 670681 acaaataaat ggatgaatag agacggagga caagcagaat gatcgaacgt tattcaagac 670741 ctgaaatgtc cgcgatttgg acggatgaaa acagatttca agcatggtta gaggttgaaa 670801 ttcttgcctg tgaagcgtgg gcggagcttg gcgtcattcc gaaagaagat gtaaaggtta 670861 tgcgcgaaaa cgcgtcattt gacatcaacc gcattttaga aatcgaaaag gacacgcgcc 670921 atgacgttgt cgcttttacg cgcgctgtat ccgaatcact gggcgaagaa agaaaatggg 670981 tgcattacgg cttaacgtca actgacgttg ttgatacggc tctttcctac ttattaaaac 671041 aggcaaacga tattttgctc aaggatcttg agagatttgt tgacattata aaagaaaaag 671101 cgaaagaaca taaatacaca gtcatgatgg ggcgcacaca cggcgtacac gctgagccta 671161 caacattcgg cttaaaactt gcgctttggc atgaagaaat gaaacgtaat cttgagcgct 671221 tcaaacaagc gaaagcaggc atcgaggttg gaaagatttc cggtgctgtc ggcacatatg 671281 cgaacattga tccatttgtt gaacaatatg tctgtgagaa gctcggattg aaagcagcac 671341 cgatttccac tcaaaccctt cagcgtgacc gccatgctga ctatatggca acacttgctt 671401 tgatcgcgac aagcatcgag aaattcgctg tggaaatccg cggactgcaa aagagtgaaa 671461 cacgtgaagt agaggaattt ttcgcgaaag ggcaaaaggg ttcatctgca atgccgcata 671521 aacgaaatcc gattggctct gaaaacatga caggcatggc gcgcgtgatc cgcggctaca 671581 tgatgacagc ttacgaaaat gttccattat ggcatgagcg cgatatttct cattcttcag 671641 cagaacgaat tattcttccg gatgcgacaa ttgcgctgaa ctacatgctg aaccgcttct 671701 ccaacatcgt gaagaactta acggtcttcc cggaaaacat gaagcgcaac atggaccgca 671761 ctctcggcct tatctattct cagcgtgtgc tccttgcttt gattgacaca ggcctgactc 671821 gtgaagaagc ctatgataca gttcagccga aagcaatgga agcgtgggaa aaacaagtgc 671881 cgttccgcga gcttgtggaa gcggaagaga aaatcacgtc acgtctttct ccagaaaaaa 671941 ttgctgactg ctttgattac aattaccatc tgaaaaatgt tgatctgatc tttgaacgtt 672001 taggtttagc atagaagaag cttttagcgg cttcttctaa gccgccgcag tttgaaaatt 672061 cccaacattc gggttaggag gccttccgtg aatattgtga agaatgaact tttatacgaa 672121 ggaaaagcaa aaaagatcta caaaaccgat gacgaaaaca cgctgtatgt cgtgtataaa 672181 gactccgcca ctgcctttaa cggcgagaaa aaagcagaaa tcagcggaaa agggcgctta 672241 aataatgaaa tttcaagcct cattttcaaa caccttcatg ctaagggcat taacaatcat 672301 tttatcgagc gcatttcgga aacggagcag ctcattaaaa aggtaacgat tgtgccgctt 672361 gaagtcgtgg taagaaatgt tgtggcagga agcatgtcca aacgtctcgg cattccagaa 672421 ggcacggagc ttgagcagcc gattatcgag ttttactaca aggatgacgc gctgggtgat 672481 ccgctcatca cagaagatca tatttggctt ttgaaggcgg cgactcctga gcaggtagaa 672541 accattaagt ccattacaac aatagtaaat gaagagcttc aaagcatctt cgacgattgt 672601 catgtcagat taatagattt caagcttgaa ttcggtttag atgcagaagg gcaagtgctt 672661 ttggcggatg aaatatctcc tgacacatgc cgcttgtggg ataaagaaac gaacgaaaag 672721 ctggacaaag atttattcag acgcaatctg ggaagcttaa ccgacgcata cgaagagatt 672781 ttcaatagac tgggaggcat tcatcatgta taaagtaaaa gtttatgtca gcttaaaaga 672841 aagtgtacta gatccacaag ggagcgctgt ccagcatgcc ttgcacagta tgacttacaa 672901 cgaagttcaa gatgtgcgca tcgggaaata catggagctt accattgaaa aatctgaccg 672961 tgatcttgac gtgctagtga aagaaatgtg cgaaaaactt cttgcgaaca cagtgattga 673021 agattataga tatgaggttg aggaggtagt cgcacagtga aatttgcggt gattgtgtta 673081 cccggctcca actgtgatat cgatatgtat catgctgtaa aggatgagct cggccatgaa 673141 gtggaatacg tctggcatga ggaaacaagc cttgacggct tcgacggcgt gttaattccg 673201 ggaggatttt cttacggcga ttacttaaga tgcggcgcca tcgcccgatt tgcgaatatt 673261 atgccagctg tcaaacaagc agcggctgaa ggaaaacctg ttcttggcgt ctgtaacgga 673321 ttccagattt tacaggagct tgggctgctg ccaggcgcaa tgagacgcaa caaagatctg 673381 aagttcattt gccgtccggt tgaattgatt gttcagaacg acgaaacctt attcacagct 673441 tcctacgaaa agggagaatc gattacaatc ccggttgccc atggtgaagg gaatttctac 673501 tgtgatgacg agacgcttgc tacattaaag gaaaacaatc aaattgcttt cacatacggc 673561 tctaatatta atggaagtgt cagcgacatt gccggtgtcg tgaatgagaa aggcaatgta 673621 ttaggcatga tgcctcaccc tgagcgcgcg gtcgatgaac tgcttggaag cgccgacggt 673681 cttaaattgt tccagtctat cgtgaaaaat tggagggaaa ctcatgtcac tactgcttga 673741 accaagtaaa gaacaaataa aagaagagaa actgtatcag caaatgggtg tcagtgatga 673801 tgagtttgca ttgatagaat ccattcttgg aagattgccg aactacacag aaatcggaat 673861 tttttctgtc atgtggtctg agcattgcag ctataaaaac tcaaagccga ttctgcgtaa 673921 attcccgaca agcggcgagc gtgtgctgca ggggccgggg gaaggcgccg gaatcgttga 673981 tatcggtgat aaccaagcgg ttgtgttcaa aattgaatca cataaccacc catcagctct 674041 cgagccttac caaggcgctg cgactggcgt aggcggaatt atccgtgatg tattctcaat 674101 gggtgcacgc ccaatcgctg tattgaactc tcttcgattt ggtgaactga cttcaccccg 674161 cgtgaagtac ttgtttgaag aagtagtagc gggtatcgcc ggatacggca actgtatcgg 674221 catcccgaca gtcggcggag aagtgcagtt tgacagcagc tatgaaggaa atccgctcgt 674281 caacgcaatg tgcgtcggtt taatcaacca tgaagacatc aaaaaaggcc aggcaaaggg 674341 tgtcggcaac acagtaatgt acgtaggagc gaaaacaggg cgtgacggca tccacggcgc 674401 tacgtttgct tctgaagaaa tgtcagactc gtctgaagaa aagcgttctg ctgtccaagt 674461 cggcgatccg tttatggaga agcttttgct tgaagcatgt ctggaagtca tccaatgcga 674521 cgccttagtc ggcattcagg atatgggagc tgccggttta acaagctcaa gtgcagaaat 674581 ggcaagtaaa gccggttctg gcattgaaat gaatcttgac ctgattcctc agcgcgaaac 674641 aggcatgacc gcgtatgaaa tgatgctttc tgaatcacaa gaacggatgc ttttggttat 674701 tgagcgcgga cgtgagcagg aaatcatcga tatttttgac aagtatgatc ttgaagcggt 674761 ttctgtcgga catgtgacag atgataaaat gcttcgcctg acacataaag gagaggttgt 674821 gtgcgagctg cctgttgatg ccttggcaga agaagcaccg gtttaccata agccttctca 674881 agagcctgct tactatcgcg agtttttgga aacagacgtt ccggctccgc aaattgaaga 674941 tgcgaatgaa atgctgaagg cccttcttca gcagccgacg attgcgagta aagagtgggt 675001 ttatgatcag tatgactaca tggtgcgcac gaatacagtt gtcgctcctg ggtctgatgc 675061 tggtgttctc agaatccgcg gaacgaaaaa ggcgctggcg atgacgacag actgtaacgc 675121 gcgttatctc tatcttgatc ctgaagtcgg agggaaaatt gctgtcgctg aagcagcgcg 675181 caacatcatt tgctcaggcg cagaaccgct tgcggtgaca gataacctta acttcggaaa 675241 ccctgagaag ccggaaatct tctggcagat cgaaaaagcg gcagacggca taagcgaagc 675301 gtgcaatgtt ctcagcactc cggttatcgg cggtaacgta tcgctttata acgaatcaaa 675361 cggcacggcg atctatccga caccagttat cggcatggtc ggcctaattg aagatacagc 675421 gcacattaca acacagcatt tcaaacaagc aggagatctc gtatacgtga tcggcgaaac 675481 aaaaccagag tttgccggaa gcgagctgca aaaaatgaca gaaggccgta tttacggcaa 675541 agcgccgcaa atcgatcttg atgtagagct gtctcgtcaa aaagcactgc ttgacgcgat 675601 taaaaaaggc ttcgttcaat ctgcgcatga tgtgtctgaa ggcggcttag gcgtagcgat 675661 tgcggaaagt gtcatgacga cggaaaacct tggcgctaat gtgactgtag aaggggaagc 675721 ggcgttatta ttctctgaat ctcaatctcg cttcgtcgtt tcagtgaaaa aagaacatca 675781 agctgcgttt gaagcaactg tcaaagatgc agttcatatt ggtgaggtaa cagctgacgg 675841 aattctggcg attcaaaacc aagacggaca acaaatgatt catgcgcaaa cgaaagagct 675901 tgaacgcgta tggaaaggag ctatcccatg cttgctgaaa tcaaaggctt aaatgaagaa 675961 tgcggcgttt ttgggatttg gggacatgaa gaagccccgc aaatcacgta ttacggtctc 676021 cacagccttc agcaccgagg acaggagggt gctggcatcg tagcgactga cggtgaaaag 676081 ctgacggctc acaaaggcca aggtctgatc actgaagtat ttcaaaacgg cgaactcagc 676141 aaagtaaagg gaaaaggcgc tatcgggcac gttcggtacg caacggctgg aggcggcgga 676201 tacgaaaatg ttcagccgct cctcttccgt tcccaaaaca acggcagcct ggcgcttgct 676261 cataacggaa atcttgtcaa cgccactcag ctgaagcagc agctcgaaaa tcaagggagc 676321 atctttcaaa cctcttcgga tacagaggtt ttggctcacc tgatcaaaag aagcggacac 676381 ttcacgctga aggatcaaat taaaaactcg ctttctatgc tgaaaggcgc ctacgcgttc 676441 ctgatcatga ccgaaacaga aatgattgtc gcacttgatc caaacgggct gagaccgcta 676501 tccatcggca tgatgggcga cgcttatgtg gtcgcatcag aaacatgcgc atttgacgtc 676561 gtcggcgcaa cgtaccttcg cgaggtagag ccgggagaaa tgctgatcat taatgatgaa 676621 ggcatgaaat cagagcgttt ttccatgaat atcaatcgtt ccatttgcag catggagtac 676681 atttatttct ccagaccaga cagcaatatt gacggtatta atgtgcacag tgcccgtaaa 676741 aaccttggga aaatgctggc tcaggaatcc gcagttgaag ctgacgtcgt aaccggggtt 676801 ccggattcca gtatttcagc ggcgatcggc tatgcagagg caacaggcat tccgtatgag 676861 cttggcttaa tcaaaaaccg ttatgttggc agaacgttta ttcagccgtc ccaggctctg 676921 cgtgagcaag gcgtcagaat gaagctgtct gcggtgcgcg gggttgtaga aggcaaacgc 676981 gtcgtgatgg tggatgactc tatcgtgcga ggaacaacta gccgccggat tgtcacgatg 677041 ctaagagaag cgggtgcgac agaggtgcat gtgaaaatca gttcaccgcc gatcgctcat 677101 ccgtgctttt acggcattga cacttccaca catgaagaac tgatcgcgtc ttcgcattct 677161 gttgaagaaa tccgtcagga aatcggagcc gataccctct catttttgag tgtggaaggg 677221 ctgctgaaag gcatcggcag aaaatacgat gactcgaatt gcggacagtg tctcgcttgc 677281 tttacaggaa aatatccgac tgaaatttac caggatacag tgcttcctca cgtaaaagaa 677341 gcagtattaa ccaaataaaa cttgaaaaat gacataaagg cagcgcagtt cggctgcctt 677401 tctctttctg ccctcgttcg gggagatatt ttgaaaagcg ccttaaagga gtgaatagga 677461 tgtctgaagc atataaaaac gcaggagttg acatcgaagc cggatatgaa gctgtaaaac 677521 gaatgaaaaa acacgtggag cgcacgaaac ggcttggcgt tatgggcagc cttggcggtt 677581 ttggcggcat gtttgacctg tctgagcttt cttatcaaaa accagttctc atttcgggaa 677641 cggacggtgt cggcacaaaa ttaaagctcg ctttttccat ggataagcat gacacgattg 677701 gcgtggatgc tgttgcaatg tgtgtcaatg acgtgctggc acaaggtgca gagccgctgt 677761 ttttcctcga ttatttagcg gttggcaaag cggacccagt gaaaattgaa cagattgtac 677821 aaggtgttgc ggaaggctgt gagcagtcag gttcagcctt agtcggcggt gaaacggctg 677881 aaatgccggg gctctataca gctgatgaat acgatattgc cggtttctca gtcggagtgg 677941 cagaaaagga cgaaatcgtg actggagaaa aaattgaaga gggccatctg ttgatcggcc 678001 tcagctccag cggccttcac agcaacggct tttcccttgt cagaaaagtg cttctggatg 678061 atgcggagct ggacctcgat acaacatatg agccgtttga acgcccgctt ggcgaggaat 678121 tgcttgaacc gacaaggatt tacgtgaagc ctgtgcttgc cgcggtcaaa agcggaaaaa 678181 tcgacggcat ggcgcacgtg acaggcggag gatttattga aaatattccg cgtatgcttc 678241 cggaaggctt aagtgcggaa attgatcatg gctcatggcc gatcccgccg attttttctt 678301 tcttgcaaga gtacggcaag ctaaaggaag aagacatgtt caacgtcttt aatatgggta 678361 tcggttttgt tttggcagtc aaagaagagc atctgacaga tgtgatcgga acgcttgaaa 678421 gccatggcga aaaagcctat ttaatcgggc gtgtgaaaaa aggtgaaggc gtcacattcg 678481 gcggtgcggc actttcatga aaaagtttgc ggtatttgca tcaggaaacg gttcaaactt 678541 cgaagccatc gtcacgcgtt tgaaggagga gaactgggat gcgtcagcag cgctcctcgt 678601 ttgcgacaaa ccgcaggcga aagtcatcga acgggcggaa gcattccaca ttccatcctt 678661 cgcatttgag ccgaagtctt atgaaaacaa ggctgcattt gaacaagcca tcattgaaca 678721 gcttcgtctt cacgaggttg aattgattgc tcttgccggc tatatgaggc tgatcggtga 678781 tacgctcctt caagcatatg ggggaaaaat cattaacatt cacccatcgc ttcttccggc 678841 gtttcctgga atcgacgcag tcggacaggc gttccgggcg ggtgtgaagg tggccggaat 678901 caccgtgcat tatgtcgatg aaggaatgga tacaggtccg atcatcgctc aaaaggcaat 678961 cgaaattgat gaacatgata cattggaaac aatcgaacag cgaattcaca agcttgagca 679021 taaatggtat ccgagtgtga ttaaacagct attaggatta aataacagag gtgaaaaggc 679081 atgaccatta aacgtgcatt aatcagtgtt tcagataaaa caaatctcgt tcctttcgta 679141 aaagaactga cagagcttgg cgttgaagtc atctccacag gcggaacgaa aaagcttctt 679201 caagaaaacg gtgtggatgt gatcggaatt tctgaagtga caggctttcc tgaaattatg 679261 gacggccggt taaaaaccct acacccgaat attcacggcg gccttctggc ggttcgcggc 679321 aatgaagagc atatggcgca gatcaatgaa cacgggattc agccgattga cctcgttgtc 679381 gtcaacctct atccatttaa agaaacgatt tctaaagaag acgtcacgta tgaagaagcg 679441 atcgaaaata tcgacatcgg cggacctggc atgctgcgcg cggcatcaaa gaaccatcag 679501 gatgtcacgg ttatcgtcga tccggccgat tacagcccag tgctaaatca aatcaaagaa 679561 gaaggcagcg tatctcttca gaaaaaacgc gagctcgcgg caaaagtatt ccgtcatact 679621 gcggcatatg atgcactgat cgctgactat ctgacaaatg ttgtcggtga aaaagaacca 679681 gagcaattca ctgtgacatt tgagaaaaaa caatcgcttc gctatggaga aaacccgcat 679741 caggaagcaa ctttctatca aacagctctt cctgtcaaag gctccattgc gcaagcagaa 679801 cagcttcacg gaaaagagct ttcttacaac aacattaaag acgcggatgc tgcagttcaa 679861 atcgttcgtg aattcactga accggctgct gttgctgtga agcatatgaa cccgtgcggc 679921 gtgggaacag gaaaaacgat cgcagaagcg tttgacagag cgtttgaagc ggataaaaca 679981 tctatcttcg gcggcattat cgcgctgaac cgtgaagtgg acaaggcaac tgccgaagcg 680041 cttcacaaca ttttcttaga aatcatcatt gcgccttcat tcagccaaga agcgctcgac 680101 gtcctgactg cgaagaaaaa tctccgtctg ctgacgcttg acgtatccgc cgctgttcaa 680161 aaggaaaaac agctgacatc cgttcaaggc gggctgctga ttcaagattt agatatgcac 680221 ggcttcgatg atgctgagat tagcattccg acaaaaagag agccgaacga gcaagagtgg 680281 gaagacttga agcttgcttg gaaagtcgtg aagcatgtga aatcaaatgc gattgttctc 680341 gcgaaggaca acatgacagt cggcgtggga gcaggccaaa tgaaccgcgt cggatcggca 680401 aaaatcgcaa tcgagcaagc aggggaaaaa gcgaagggca gcgcgctcgg ttcggatgca 680461 tatttcccaa tgccagatac tgtcgaagaa gcggcaaaag cgggcgttac agccatcatt 680521 cagccaggcg gatcgatccg agatgaggat tccatcaaaa aagcggatga atacggcatt 680581 gccatggtat tcaccggcat cagacacttc aaacattaag gggatgaaaa cgacgtgaat 680641 gtattaatta tcggtaaagg cggaagagaa catacgctgg cgtggaaggc agcgcaaagc 680701 agcctcgtcg agaatgtatt tgccgctccc ggaaatgacg gcatggcagc ttccgctcag 680761 cttgtaaaca ttgaggaaag cgaccacgca gggcttgtct catttgcaaa acaaaatcag 680821 gtcggcctga ccattgtcgg ccctgaggtt cctttaattg aaggtctggt ggatgaattc 680881 gaaaaagcgg gcttacatgt gttcggtccg tcaaaagctg cggcgatcat cgaaggaagc 680941 aaacagttcg ctaaggattt aatgaagaaa tacgacattc cgaccgcaga atacgagacg 681001 tttacatcct ttgatgaggc gaaggcatat gtgcaggaaa aaggtgctcc gattgtgata 681061 aaagcagatg gacttgcagc tggaaaaggc gttactgtgg ctatgacaga ggaagaagca 681121 attgcgtgct tgcatgactt tcttgaagat gaaaagttcg gtgatgcgag cgcgtccgtt 681181 gtcattgaag aatatctttc tggtgaagaa ttttctctaa tggcctttgt caaaggggaa 681241 aaggtgtatc cgatggtgat tgcccaggat cacaagcggg cgtttgacgg agacaaaggc 681301 ccgaatacag gcggcatggg cgcctactcg ccagttccgc aaatttcgga agaaacggtc 681361 cgccatgctg tagaaacgat cgttaagccg gctgcaaaag caatggtaca agaaggccgt 681421 tccttcactg gcgttttgta cgctggattg atgcttactg aaaacggctc gaaggtcatt 681481 gaatttaatg cccgtttcgg cgatccggaa acacaggtcg tgcttccgcg catggaatct 681541 gatctggtac aggtgcttct tgatctttta gatgataagg aagttgactt aagatggaag 681601 gataccgcgg cagtgagtgt tgtgcttgca tcagaagggt atccggaaag ctatgcaaaa 681661 ggcacgccga tcggcagcct tgcagcagaa actgagcagg tcgtggtctt ccatgccgga 681721 acgaaagcag aaggtggaga gttcgttaca aacggggggc gcgtcgccaa tgtgacggct 681781 tttgatgaaa cgtttgaagc ggctagagac cgagtgtaca aagcggttga tgaaattttc 681841 aaaccgggac tctttttcag aaaagacatt ggggcacgcg ctttaaaggc tgcccaaaaa 681901 taagtgagga aaacccgcag aatagctgcg ggttttttgt tatcaaaaag cgggatggca 681961 gctagaagaa gaaagcacaa cgagcgtggt tggttttcca tgggccatcg aggtgtcaat 682021 aaaatcctca agcgtatgta ccgattcagt cacgaccttt gtcacatagc tgtacatccc 682081 cgtgatgcgg tggttttctg ctacatcagg atgcgatgtt gcaaaggcgg cgtagtgctt 682141 gcagcttttc ggctccatga gaataaaagc ggtgacatgc ttgtttagtt tttcgtaaca 682201 gatattcgcg ctgtagccgg taatcactcc tttgtcttcc agcttcctga cacgctccgc 682261 cgcgcttggc gagctgagtc cgacaagctt tcccagctca accatcgtta atctgccgtt 682321 tcgctgcaaa tgcgagagaa tctgaaggtc tgtatcgtcc atttgtctgg ctcctttaca 682381 tatttaggcg aatgaatgaa aattcctttg atcgtaaggt aatgctgttg atttaacttc 682441 attgtagcat atggatgccg tcttattttt tctataataa agccatcaat cagagagggg 682501 gcatcatgtt gccagaattg cagcgctcta ttacttggat acaagggacg gcgttaacga 682561 ttggggcggt tttaggatgc gggatattaa tcctgccgtc tgtcaccgcg gacacggccg 682621 gccccgcttc tttatttgtt tgggtgttca tgtccttctt atcctttttt cttgtcggca 682681 cgctggcccg gcttgtgaaa atagcgccta gcgcgggagg aatcacggct tatgtgcagc 682741 tggcctttca gaaaaaagcc ggggctattt tgggctggat catgttaggg tccgttccga 682801 tcggcgttcc catcatcgct ttgactggcg cgcattacgt cagttacatc acagaggcgg 682861 ccgattggca gattacattg attgctggtt gcatgctggc tatatctatt ttgcttcata 682921 tgagagggat tcaactatca gcaaacatta gtacactcgt tatatgtgtc atcgtatttc 682981 tgcttgtcac ttctattgct gtgtcattgc cacacgtcac gatagcagaa ttcaagccgt 683041 ttcttccgca tggctggtct gccgctggat ctgtttctgt tatgattttt ttctcttttg 683101 taggctggga aatgattacc ccgttggctg aggaatttca tcgtcctgaa aaagatgtcc 683161 cgctcagctt gtttttggca gcgtcttgtg tggcggggct gtatatcatg ctgtcatttg 683221 tgaccgtggg tactcattca tatggagaga atggagaaat tgcatcgctt gccatgctca 683281 tttcaaaagg agcaggagaa agcggtgtat atgtcacggt atgtttagcg ctgtttatta 683341 cattcgccac catccatgcc aatattgccg gtttttcaag aatggtgtac gcattggcga 683401 gagaggggca catacccgta ttttttggaa aactcagtgc gacaaaacgt acgcctattc 683461 gcgttttgac agcgatggcc gcagtgtttg gcttagtgct tgcagcgcat ggtctgtttc 683521 aaatcgattt gacgactctg ttgaaagggc cgagcgcggc ttttatcgca tcttacatat 683581 gtacaatggc ggcagcactg aaactgctgg gcaggagaga tataggctgg tggatggcgc 683641 tcggggcatt tgtggcgtgc gcggtgattt attcattcag cggctgggca ctgctttatc 683701 cggcagtgct ggcagctgca ggatatttct atatgaaaac aaagggtggg cataaaaaaa 683761 agcttgatca cgttttgtga tcaagctttt ccatttatcc gttttgatgc tcgttatttc 683821 cagaatcgct gtgttgaaac atgtaggtca caggacagaa gcgcaagatt cccgaacccg 683881 ctttcatggc ccccataaag atgtaaaaga gatgcattct gcaccaaggt tttttcgtaa 683941 actttgcact ggcggctgac ataatcgtca atccgcaggc gattctgaac acggcattga 684001 tgagactgat gtttggcttc aaggaaatcc gctcctttta cttaaaaaag ttttttaatc 684061 gaaccttcaa aaatttgtaa cgtttttatc gtgcgtgatg aggaaggatg tgataccatg 684121 agtctaatac atgtaaagga gagtatgtga atgtccgaac gcacctttaa ctggaaaaac 684181 aaagacatca gggcacaggt tgatgttgta gactcaaagc tgcttccaac gctcctttta 684241 cggaatgctc tcgtcttaaa tccatatgta aaacaatggc tgaaaaaaaa catttggatt 684301 tatcaggacc gcattgttta tgtgggtcat gaacttccga atagagccga agaaattcat 684361 acgattgatt gtgaaggaaa atacattgtg ccaggttata ttgaaccgca cgcacatcct 684421 tttcaaatat ataatcccca aacactggcg gaatatgtgt ctcaatacgg aacaacgaca 684481 ttcgtgaatg ataacttatt tttgcttttg caaagcggaa aaaagaaagc gcttacgatt 684541 ttgaatgaac tcaaaaagca gcctgtccag tatttttggt ggtcacgcta tgacctccag 684601 accgaggttc tgaacgagga ccacgtcctt ccatttgacg tcagaaaaca gtggattgaa 684661 catccggatg tgattcaagg cggagaaatg accggatggc ctcgcctggt agatggtgat 684721 gatttaatgc tccactgtat gcaagctaca aagaaacaga gaaaacgtat tgaagggcat 684781 tttcccggcg cttctgataa aacgcttaca aaaatgaagc tgttcggtgc ggattgtgat 684841 catgaagcga tgacaggtga tgaagtgatg agaaggctgg aactgggcta ttatgtttcc 684901 cttcggaact cttccattcg ccccgatgta agaaaaatct tgcaagagct gcatgagaag 684961 ggcttccgct attatgacca cttcttttac acgacagatg gcgcaacccc gaatttctat 685021 aaaggcggca tgacaaacga gctgattcgc attgcgttag aagaaggcgt acctgcaatc 685081 gacgcctaca atatggcatc atttaatatc gcaaagtatt accaaatgga tgattattta 685141 ggagttgtcg gaccgggcag actggcatcg ctaaacatac tggaagatcc gttaaatccg 685201 aatccagtga ctgttctgtc aaaagggacc attctgcgtg aaaacggctg tgatttgaag 685261 gcgtttacaa agacggactg gcacaaaggc ggtcttgtcc cgcttgagct ttcatatgat 685321 atgacgatgg atgacttgca gttttctatg ccgatgggcg tgaaaatgcg gaatgcggtt 685381 attatggagc catatatgat tgagatcgac aattcgatgg aacagctctc gtttgaccat 685441 gatgaaagtt atttgacgat gctcgacaga cacgggaaat ggcgcgtcaa tacgatgata 685501 aaagggtttg cctcaagcgt gcagggattt gtaagctcct ttacgacgac gggcgacatt 685561 gtcgcgattg gaaaaaataa agcggatatg ctgctcgctt tcgcccgcat gaaagaaatc 685621 ggaggaggaa ttgttttagc ggagaacgga aacattctgc atgaaatccc gcttgcgctg 685681 tgcggctgcg cctcttcgga agcgtatgaa gacgtgcttg agaaggaaca aaagctgaga 685741 gatcttttga ctgaaagagg ctatgagttt tgcgatccta tctatacgct gctctttttg 685801 caaagtacgc accttccgta tatacgcatt acgccaagag gaatattcga cgtcatgaaa 685861 aaaactgtac tctttccatc gataatgcgt taaaatataa aagagcaggg agccgacata 685921 tgaaaaaatg gatgacagtt tgcgcgctgt gtttcgtgtt ttttctgctg gtatcctgcc 685981 agcagaagga tgctgtcccg gatactgcaa agaagctgaa agctccttta acggggctaa 686041 agactgaaca gaaagtgact gaacgccgcc ctgttgctgt tgtggtgaac aatcacccga 686101 aggcgaggcc gcagtcgggt ctgtctaaag ccgacattgt catagaagcg ctagccgaag 686161 ggcaaatcac aagatttctg gccattttcc aaagccagat gcctgaaact gtcggacctg 686221 tgcggagcgc gcgggaatat ttcgtcactc tcagcaatgg ctttgacagc atatttgtcc 686281 atcacggctg gagtcccggc gccaaaaagc agctggaatc cggagctgcc gattatatga 686341 acggattgga ttttgacgga agcttatttt ggagagctga tttcagcaaa ccgccccaca 686401 attcctatac gtcttatgat tacataaaaa aggcggcaga acaaaagggt tataagctga 686461 agcaggaaac aaatccgctg ctgtttcaaa catcagatgc aaaacctgca aatgaatctt 686521 acaatgttcg ggtagattat ggaacaaata acgttacaaa tcttgtcgaa tacaactatg 686581 ataaaaaagc tgaattttat acaagaagct ctgatggtgt cataacgaca gaccgggaaa 686641 ccggaaagcc ggttgcaatg caaaatattt tcattgttga agccagccat catattattg 686701 atcaagatgg aaggcgggac atcgacttgg aatcaggagg aaaaggtctg ttgtttcagc 686761 acggaaacgt cattgaaaca gactggaaac aagtgaatgg cagaattgtg ccggtaaaag 686821 acggcaagtg gcttccgttt gtgccaggaa agacttggat caatatcgta cctgatcttg 686881 atgcggcttc cattagtaaa ggagaaggtg tgtaacgatg caaatcgata aattacgcgg 686941 caaagagctg gaccagttat ttaactcgat cttatcgctg aaagacctgg aggaatgtta 687001 ccgattcttc gatgatctat gcacaattaa cgaaattcaa tcgctggctc agcgccttga 687061 agtggcgcgc atgcttcgcg aaggaaacac gtatcataag attgaaacag aaacaggcgc 687121 ttccacggct acgatttccc gtgtgaaacg ctgcttaaat tacggaaatg acgcttatga 687181 aatggcgctt gaccgtgtga aggagacgga aacagagtct tcttccaaat aaaaaaccgc 687241 cctgccgtct ggcaagggcg gtttctttat gaaacaaatt gatggatcag gttgtcgata 687301 ttgatgatac tgccatcctc tttccgatag acaacatgct ccttggaaaa atgaatcggc 687361 gaattaatcc ctgctgcggc tgcaaggtta aatagtccct cgcgcaatga aataacgtag 687421 ttgcagacac gatgctgttt ttcctcaacg ctcagtgctt tttgcaattt cggatctgtc 687481 gtcgccacac ctgccggaca ggtgttggtg tggcagacga gagcgcggat gcagccaacg 687541 gaaaacatca tgccgcgtgc gatgttaaca aagtcagcgc cgagggctaa ggcgaccgcg 687601 attttatcag gagtcaggag ctttccggaa gcaaagattt tcagctggct gcgcaagccg 687661 tactgtttaa gaagcgtgtc cacaataggc agcgctgtca taatcggaag gccgactgta 687721 tccgcgagct cgtaaaagga agctccggta ccgccttcac ttccgtcgat cgtgataaaa 687781 tccggatgct ttccgctttt ctgcatatga gagaaaagct catgcaattc ttcaggatgc 687841 cctgcgacca gtttgatgcc gactggcttt tgtccgacat ctctaagttt ttcaataaag 687901 tcgagcattt caggagggtt tgagaattca taaaagcggt tcgggctgtc aatcgacttt 687961 ccaggttcga cattccgaat gtctgccact tcctctgata ctttggcgcc gtccacatgg 688021 ccgccgcggg ttttcgctcc ttgtgccagc tttagctcaa acgctttaat ctggtcaatc 688081 ctgctttttc ttttaaattc ctcccacgaa aattccccgt ttcttttgcg cacgccgaat 688141 aggcccggtc cgatttggca aatgatatcg gcgccgccct ttaagtgata ttcagacaat 688201 cccccttcac ctgtattcat ccaggtgccg cctgccagat ggagcccttt tgagagcgcc 688261 gtaacagccc gttctccaag agaaccgtag ctcatggcag actggccgac taagcccttc 688321 acataaaatg gcttctcgca tgtatgctcg ccaatcacct gtacatcatc aggatggaga 688381 aaatacgggt ctgccttgat atgttcggca tgctccttgc gtttgaacag attgtcagca 688441 tccattttat agatttgggt ttcaattttt ggcgtttgat ttacatgcat ttcttccctt 688501 tgttttggaa acatagcgtt acggatataa tagccaggtt tatcaaaatc tcttacagat 688561 ccaaagccca tcattctgct tttgtatttg ccggagatga cggtttgctc atattccttt 688621 cgtgaaaatg gctgctcttc attgtcattg ctgtataaat actgtctgag ctccggcccg 688681 attttttcaa ggatataccg aaaccttccg atgacgggat agttgcgaag aattgagtgc 688741 tcctgctgtt tttcatcctt tatgtagatc caggcaaaca agacgatcgg gatagcgatg 688801 atcccaatga taaatgcgat gagtgctatt atgatggttt ccatctctca gcctcccttt 688861 ttatgtaacc atttccacag tagaacactt tccaaacaat agcagaagga atctggtgaa 688921 aaatgtgtgc tcctgccgat acaggactca ccatgcaggt actgccatat gctctctttt 688981 tttatgaaaa aagaatcaaa acaccttttt cagtgaataa cgagattaac ggctttttcc 689041 gtttttccgc gctatgtgaa tttgttataa tgtttaaatg gtaacaaacg aatggaggaa 689101 cgtatgacgt gtacgatgta acggagtgga agcatgtctt taaactcgat ccaaataaag 689161 atttgcctga cgaacagctg gagattcttt gcgaatcagg aacggatgcg gtcattatcg 689221 gaggaagcga tggtgtgaca gaggataatg tcctgcggat gatgtctaag gtaagacggt 689281 ttttggtgcc gtgtgtccta gaggtatcag cgattgaagc gattgttccc ggctttgact 689341 tatattttat tccgagtgta ttaaacagca aaaacgcgga ttggattgtc ggaatgcacc 689401 agaaagccat gaaggaatac ggagaactga tgtctatgga agaaatcgtg gcggagggct 689461 actgcatcgc aaatccagat tgcaaagccg cggcactgac tgaagcggac gccgatctga 689521 atatggatga tattgtcgcc tatgcgcgtg tgtcggagct gctgcaactg ccgatttttt 689581 atttagaata cagcggcgtg cttggagaca tagaagctgt caagaaaacg aaggctgtat 689641 tggaaacgtc caccttgttt tacggcggcg gcatcaagga tgcggaaacg gccaagcagt 689701 acgcagagca tgcggacgtg atcgttgtag gcaatgcggt gtatgaagat tttgacaggg 689761 ctttgaaaac agtagcggct gtgaaaggcg agtagtaaat tgtacggatt tggtttatga 689821 tagaacgtat gttttgtata ggcgggtgaa caaattttga attatattag caatcaatta 689881 ctaagcggtt taaaccccgt tcagcaggaa gcagtcaaaa caacggacgg gcctcttttg 689941 ctgatggcgg gagcgggtag cggaaagacg cgtgtcctga cccatagaat tgcttattta 690001 atggcagaaa agcatgtggc gccgtggaac attctggcga tcacatttac aaataaagcg 690061 gcacgcgaaa tgaaagaacg tgtggaaagc atcctcggac ccggcgcgga cgatatctgg 690121 atctccacat tccacagcat gtgcgtgcgg atcttgcgca gagatatcga ccggattggg 690181 atcaaccgaa atttctccat ccttgatacg gctgaccagc tttcagtgat caaggggatt 690241 ttgaaggagc gcaatcttga tccgaagaag tttgacccga gaagcatcct cggcacgatc 690301 agcagtgcaa aaaacgaatt gaccgaaccg gaggaattct ctaaagttgc tggcggctac 690361 tacgatcagg tggtcagcga tgtatatgct gattatcaga agaagctatt gaaaaaccag 690421 tcgctcgatt tcgacgattt aattatgacg acgattaaac tgtttgacag agtgcctgaa 690481 gtgcttgaat tttatcagcg caaattccag tacatccacg ttgatgagta tcaggatacg 690541 aacagggcac aatacatgct cgttaagcag cttgccgagc gtttccagaa cctttgcgtt 690601 gtgggggatt ctgatcagtc aatctacaga tggcgcggcg cggatatcac caacattctt 690661 tcatttgaaa aagattatcc gaatgcaagc gtgattttgc tagaacaaaa ctatcgttca 690721 acgaaacgga ttttgcgcgc ggctaacgag gtcattaaaa acaactctaa ccgcaaaccg 690781 aaaaatttgt ggacggaaaa tgatgaaggc atcaagattt cctattatcg cggtgataat 690841 gagttcggtg aaggacagtt tgtggccggc aaaattcatc agcttcacag cacaggcaag 690901 cggaagctgt cggatatcgc catattatac cggacaaacg cgcagtcccg tgtgattgag 690961 gaaacgcttc tcaaagcggg cttgaactat aacattgtcg gcggcacaaa gttctatgac 691021 agaaaagaaa ttaaagacat tcttgcgtac ctgcgcctcg tatccaatcc ggatgacgat 691081 atcagtttca cgcgcattgt caatgtgccg aagcgcggag tcggcgcgac atcacttgaa 691141 aaaatcgctt cgtatgcggc cataaacggc ttgtcctttt tccaagcgat tcagcaggtt 691201 gattttatcg gcgtcagtgc caaagcggca aacgcgcttg acagctttag acagatgatt 691261 gaaaacctga ccaatatgca ggattactta tccattacag agctgacaga agaaattctt 691321 gataagacgg aatacagaga aatgctgaag gctgagaaat cgatcgaagc ccaaagccgt 691381 ttagaaaata tcgacgagtt cctgtctgtt acgaaaaact ttgaacagaa aagtgaagac 691441 aagacactcg ttgcgttcct gacagacttg gcattgatcg cagatattga tcagctcgat 691501 cagaaggagg aagagtcagg cggcaaggat gcgatcaccc tgatgacact gcacgccgcg 691561 aaaggactgg agtttccggt tgttttcttg atggggcttg aagaaggcgt cttcccgcat 691621 agccgttcac tcatggagga agcggaaatg gaagaagaac gccgccttgc gtacgttggg 691681 attacaaggg cggaacagga gctttatctg accaatgcta aaatgcgcac cttgtttggc 691741 cggacaaata tgaacccgga atctcgcttc attgctgaaa taccggatga tttattggaa 691801 aacctaaatg agaaaaaaga aacaagagcg acgtctgcga gaaaaatgca gccgagacgc 691861 ggccctgttt cacgcccggt atcctacgcc agcaaaacag gcggcgacac cttgaactgg 691921 gcagtcggag ataaggcggg ccataaaaaa tggggaacag gaactgtcgt cagcgtgaaa 691981 ggcgaaggag aagggacaga gcttgatatt gccttcccga gccctgtcgg cgtgaaacgc 692041 ctgttagcag catttgctcc tattgaaaag cagtaattga agaggaaagg aagaagcaga 692101 tggacaaaga aacagcgaag cagcgggcag aagaactgcg ccgcaccatc aacaagtata 692161 gctatgaata ttacacctta gatgaaccga gcgtcccaga tgccgaatac gacagattga 692221 tgcaggagct gatcgcgatc gaggaggagc acccagacct cagaacgcct gactctccta 692281 cgcagcgcgt cggcggagcc gtgcttgaag cgtttcagaa agtcacccac ggcacaccga 692341 tgctcagtct gggcaacgcc tttaatgctg atgatcttcg tgatttcgac cgccgtgtgc 692401 gccagtccgt cggcgacgat gtggcgtata atgtggagct gaaaatagac ggtcttgctg 692461 tttctctccg ttatgaagac ggctattttg tcagaggggc cacaagaggt gacgggacga 692521 cgggagagga tatcacggag aatctgaaga cgatccgcaa tatccccctt aaaatgaacc 692581 gtgagctgtc gatcgaagtg cgcggcgagg cgtatatgcc gaagcgttcg tttgaagcac 692641 tcaatgagga acggattaaa aatgaggaag aaccgttcgc caatccgcga aatgccgcgg 692701 cgggatctct cagacagctc gatccgaaaa ttgcagcgaa acgaaacctc gatatcttcg 692761 tctacagtat agcggagctt gacgagatgg gtgtagagac gcaaagccaa gggcttgatt 692821 ttctcgacga actcggattt aaaacgaatc aggaacgaaa aaaatgcggc agcatagaag 692881 aagtcattac gctgatcgat gagcttcagg cgaagcgcgc ggacctgccg tacgaaatag 692941 acggcattgt cattaaagtc gattctctcg atcaacagga ggagctcggt tttacggcga 693001 aaagcccgcg ctgggccatc gcgtataagt ttcctgctga agaggtcgtg acgaagcttc 693061 tcgatatcga attaaatgtc ggcagaacgg gtgtgattac gccgactgcg attcttgagc 693121 cggtaaaagt tgccggcaca acggtctcaa gagcatccct tcataacgaa gatttaatta 693181 aagagaagga cattcggatt ttggataagg ttgtcgtcaa aaaagcgggc gatatcatcc 693241 cggaagttgt gaatgtcctc gttgaccagc gcacaggaga agaaaaggaa ttcagcatgc 693301 cgacggaatg tcctgaatgc ggcagtgaac tcgtccggat cgaaggagaa gtggcgcttc 693361 gctgcattaa ccctgaatgt ccggcgcaaa tccgggaagg gcttatccat ttcgtttccc 693421 ggaatgccat gaacattgat gggctcggcg aacgagtgat cacacagctg tttgaggaaa 693481 accttgtccg caatgtggca gatttatata agctgacgaa ggaacgagtc atccagctcg 693541 agcgcatggg cgaaaagtcc actgaaaacc tgatcagctc catccaaaaa tcaaaagaaa 693601 attcgttaga gcgcctgctg tttgggcttg gcatccgttt tatcggatca aaggccgcaa 693661 agacgcttgc catgcatttt gaaagcttgg agaacctgaa aaaagcctct aaagaggaac 693721 ttctcgcggt agatgaaatc ggtgaaaaaa tggctgatgc tgtgatcacc tattttcata 693781 aagaagaaat gcttgaactc ttgaatgaac ttcaggagct gggcgtaaac acgctctaca 693841 aaggcccgaa aaaagtaaaa gcagaggaca gcgactctta ctttgctggt aaaacaattg 693901 ttctgacagg aaagctggaa gagctgtcaa gaaacgaagc caaagcgcaa atcgaagcgc 693961 tgggcggaaa gctgactgga agcgtcagca aaaacacaga cttagtcatc gccggagaag 694021 cggcgggaag caagctgaca aaagcacaag agctgaacat tgaagtgtgg aatgaagaac 694081 agttaatggg agagctaaag aaataagagg agtgttttct attgaaaaag acgttggcat 694141 tggcggcaac ggcggcagta ttaatgctgt ctgcctgctc gtcaggtttc gggggggaga 694201 aggaggaaga gattacgcaa aagacggcga aatcgtcaga aaaagcgatt gtcccgaaat 694261 ataatatctc tgactcctat tacaaaatgg tgctgccgtt taaggcaggc aaagcgcgcg 694321 gcttaacaac ggaacagctg aatacaaggc tggacattga cgaatttgaa acagggctga 694381 tgcgccttgc ccaagattct ttctcaactg acgattatct gttccaagaa ggacaatatt 694441 tagatgagga tacagtatta agctggctgg cacggaaaaa aacgggctct gatttgaaaa 694501 aagccgaaaa agaagataag aacttcaaaa atgaaggctt gaacccggcg ctcccgagtt 694561 ctggttcaac agaagaaaag aacgaaagca gcccaattta tttagcatcc atgcttgagc 694621 acgattattt agtcagaaaa gacaagaatt ctatccagct tggcggcgtc atgatcggac 694681 tggcgttaaa ctcagtgtat tactatcgtg aaaaaactgg cgacccgcaa aaagaagtgg 694741 agattaaaga cagcacgctt cgccagcagg gagaaaaaat tgcacaggag gttattaacc 694801 gcctccgcaa aaaagataac ttgaagaatg tgccgattac cgtggcgctc tacaagcagg 694861 cgtcaaaaac atcgattgtg ccggggaact tcatcgccaa aacagaggtc aaagcaggct 694921 ctactgatat ctcaaattgg gatgacatca atgaaaaata tgtattctat ccggcggata 694981 caaccacagc agaaaagtac ccggatgaca ccgaggtctt taagcggttc aaaaactcaa 695041 ttgaagaata tttcccgaac tatacaggcg ttgtcggtac agcgctgtat gaaaatgatg 695101 aaatgaagaa aatgaagatt gacataccaa tgcaattcta cggaaaaagt gaagttgtcg 695161 cgtttaccca gttcttaacg ggtgaagtga tggactacta ctctaagagc tcagttgatg 695221 tcgaagtcaa tatcacgtcc tcagacggac aggaagcggt cattatccgc aatgccggag 695281 ataaagagcc gactgttcac atttatgact gatagaaaac ccttgtgcca tattggcaca 695341 agggttttta tgttacaatt aacaggaaaa gggaaaatat tttcacttct gccgaaacac 695401 aaatcaaggg gaggtatgtt gatgctggaa atcgtgtgaa aacaatcatt atcaaatcta 695461 tagcaatgaa aggatgttag acgtgcataa agatatcaaa aaaatatttc atgaagagca 695521 ggttttggca gaagctgcag cgagatacgg tttctcaaaa gatcaggtgc gttttctggc 695581 tgatgcggaa aactatgtat atgaatgtat gaaagacaat caaccttata ttttaaagat 695641 tacccatacg attcggagat cttctgatta tatgatggga gagatggaat ggctccgtca 695701 ccttgcaata gggggaattt cagtagccaa accgctcccg tcgctgaacg gaaaagacgt 695761 agaagcagtg ccggacggaa acggcgggtc atttttattg agagtgtatg agaaagcgcc 695821 ggggcaaaaa gtggatgaat cggactggaa tgaaacgcta ttttatgagc ttggcagata 695881 cacaggcagc atgcacagcc tgacaaaaag ctacaaattg agcaatcccg ctttcaaaag 695941 acaggaatgg gatgaagagg agcaattaaa gctgagaaaa tatgtgcctg aagatcagat 696001 aaaggtgttt cagcaagccg attctttgat gaatgaactg cggaggctcc cgaaaagcca 696061 ggacaactac ggcttggtgc atgcggatct gcaccatggc aattttaact gggatcatgg 696121 caaaatcacg gcatttgatt ttgatgatat cggctacaac tggtttgtta acgatattag 696181 cattcttctc tacaatgtcc tgtggtatcc tgttgtgcca tatgatgata aagctgcgtt 696241 tacagaagaa tttatgacgc attttatgaa agggtactgg gaggaaaatg agcttgaccc 696301 tgcatggctg atgataatac ctgatttcct ccgccttcgc catatgctga tttacggatt 696361 gctgcatcag atgtttgacc ttaacacaat aggagaagag gaaaaagaaa tgctggccgg 696421 tttcagaaga gatatagaga atggcacgcc gattacagca tttgattttt cagcactggt 696481 gtagatagaa aaagccaatg ggattccagt cccattggct tttataatgt atcacacttc 696541 acgccgacta cgccttcaat ggctttaatg tcatagtaga catcggtcgt gtatctgttt 696601 ttatggacgc ggaccttcac ttccataatt ggaaaatcct tttcgcctag gtcgtcgatc 696661 cgaacggagt gtgctttgat atctcttctt ttcatttctt ttaaaatctc tgtcattttg 696721 tctttatcag aaagtgacat tctgatgcgg atgtcttttt cctgcaggcg gtcggggccg 696781 atttttctga ccacccatgg gagaaattcc acactgatca ggatgaacag aagactggca 696841 aacgcttctt tataaaaacc ggctcccgta gcaagcccga gccccgctgc cccccagatc 696901 atggccgatg tcgtcaggcc ggaaatgaca tcattgcttt ttcgcaggat gacaccggcg 696961 ccgataaacc cgacgccgga gatgatttgt gccggcagac gaagcggatc catcatgatg 697021 cggtagtatt tagggaaatg atatgccgca ttaatactga cgatcgtcag catgcatgag 697081 ctgactgcga tgacaataca ggtttttaat ccgagcggct tattttttaa ttcgcgttca 697141 agcccgatga ccatgccaat caatgtggca atgcccaatt tcaataaaat atcaggatca 697201 atataccagc tcaacagcaa acttccccct tctctatggt gtttttaaat aaatatgatt 697261 ttctcacagt atttatagca aaacaagagc acaaaagcca ccaagctgcg cttgatggct 697321 tattgcttac tttttgcgtt ttaacagctt ttccatgaca ccgaataatc ggtaagaggc 697381 ttttgcagga cgttttgtga tcatgctgac aatgatgccg gcaatcatac tgagaataaa 697441 cccagggatg atttcgtaca caccggttga ttttgccagg ccggttgtaa tccagatcaa 697501 cacggtcgca gccccgacaa tcatggcagc aagcgcgccc cattcgttca ttcgtttcca 697561 atacagactg agcagaatcg caggcccgaa agctgaaccg aagccggccc aagcgtatcc 697621 gaccaaatca agaatggtgc tgttcgggtt caatgacaag agtaccgcga taacggcaat 697681 gactaagacg gacaatcgcc cgatcatgac caattcttta tcagaagctt ttcgtctgaa 697741 aaatgaccgg tataaatcct ctgttacagc acttgctgtg accaagagct gtgaggaaat 697801 cgaactcatg atggcagcca aaatagctga caataagaac cctgtaatta atgggtggaa 697861 caagatttta gagaagataa tgaaaatcat ctccggatct tttacagcaa ctccgaattt 697921 atgggcgtat gcaacaccga ttaaacccgt cagcacggaa cctagaactg taatgatcat 697981 ccagctcatg ccgattcggc gtgcaggttt taaatcttta atgtctttaa tggccataaa 698041 tcggacgatg atatgaggct ggccgtagta gcccaacccc caggctaaat aggaaataat 698101 gctaatgacg ctcgcgcctt taaaaatatc caataaatgt ggattaacag cgtcgatttc 698161 atggaaagtc ggagcaacgc cgcccacatg ggtaaaagca acgatcggca caagcactag 698221 tgctgcaaac atgatcgcac cctgcacgaa gtcagtcaga ctgacagcaa ggaaaccgcc 698281 aaacagtgtg tataacacga caactgcggt ggtcagaaac aggcctaatt tgtaatccgc 698341 accaaaagca gattcaaaca gccgtccgcc agataccata ccggaagagg tatacaatgt 698401 gaaaaagatc atgatgatca atgcagatac gattttcagc agtgatgaag aatgctggaa 698461 tcgtttatca aagaaatcag gaattgtaat cgcatcatct gccgcttctg tataagcacg 698521 cagccttgga gccagcagca agtaatttga gtacgccccg attgtaagac ctaaagcaag 698581 ccataaggtg gacagccctg tcgcaaacat cgcgccggga acacccatca gcatccatcc 698641 gctcatatcg gccgcgccgg cagacaaagc agtaacgaat ggtccgaggc ctcttcctcc 698701 aagcatgtaa tcattgatgt cagtggtttt cttgaatgca taccagccga ttaacagcat 698761 ggcaataaag taaattccta aagatataat aatttcaata ctcacgtttt accctctctt 698821 catttctaat aatgttgcat cacctctcaa attgatggtg ccagttaagc agcctggcgt 698881 aagtgcaaaa caaaagaaat tcttttgcgg gtgcacttgg taacttaacc taacaaagta 698941 ttcccggcca ttcaagcgat gaaacattga tcataagctg gaaataccgt tgcaaaccta 699001 gaagggaata aagaataaaa cgctttcaaa aaataattaa agtaaaaata ttcagaaaaa 699061 tatttcgttt ctccttctcc tcattttagt ataaaatata tagggtattg tttcgaaaac 699121 acaggcctgt ctcaaggcgt tttgttgctt taaagggctt gtttttgata tgatcagtat 699181 tatatgactt aacggagaaa tatgtggagg tggatcatat gtcacgaatt tcaatagaag 699241 aagtaaagca cgttgcgcac cttgcaagac ttgcgattac tgaagaagaa gcaaaaatgt 699301 tcactgaaca gctcgacagt atcatttcat ttgccgagga gcttaatgag gttaacacag 699361 acaatgtgga gcctacaact cacgtgctga aaatgaaaaa tgtcatgaga gaagatgaag 699421 cgggtaaagg tcttccggtt gaggatgtca tgaaaaatgc gcctgaccat aaagacggct 699481 atattcgtgt gccatcaatt ctggactaaa ggagggacac aagaatgtca ttatttgatc 699541 ataaaatcac agaattaaaa cagctcatac ataaaaaaga gattaagatt tctgatctgg 699601 ttgatgaatc ttataaacgc atccaagcgg ttgatgataa ggtacaagcc tttttggcat 699661 tagatgaaga aagagcgcgc gcatacgcga aggagcttga tgaggcggtt gacggccgtt 699721 ctgagcacgg tcttcttttc ggtatgccga tcggcgtaaa agataatatc gtaacaaaag 699781 ggctgcgcac aacatgctcc agcaaaattc tcgaaaactt tgatccgatt tacgatgcta 699841 ctgtcgttca gcgccttcaa gacgctgaag cggtcacaat cggaaaactg aacatggacg 699901 aattcgccat ggggtcatct acagaaaact cagcttacaa gctgacgaaa aacccttgga 699961 acctggatac agttcccggc ggttcaagcg gcggatctgc agctgcggtt gctgcgggag 700021 aagttccgtt ttctcttgga tctgacacag gcggctccat ccgtcagccg gcatctttct 700081 gcggcgttgt cggattaaaa cctacatacg gacgtgtatc tcgttacggc ctggtcgcat 700141 ttgcgtcttc attggaccaa atcggaccga ttacacgtac ggttgaggat aacgcgtttt 700201 tacttcaagc gatttccggc gtagacaaaa tggactctac gagtgcaaat gtggacgtgc 700261 ctgattttct ttcttcatta actggcgaca tcaaaggact gaaaatcgcc gttccgaaag 700321 aataccttgg tgaaggtgtc ggcaaagaag cgagagaatc tgtcttggca gcgctgaaag 700381 tccttgaagg tctcggcgct acatgggaag aagtgtctct tccgcacagt aaatacgcgc 700441 ttgcgacata ttacctgctg tcatcttctg aagcgtcagc gaaccttgca cgctttgacg 700501 gcatccgcta cggctaccgc acagacaacg cggataacct gatcgacctt tacaagcaaa 700561 cgcgcgctga aggtttcgga aatgaagtca aacgccgcat catgctcgga acgtttgctt 700621 taagctcagg ctactacgat gcgtactaca aaaaagcgca aaaagtgcgt acgttgatta 700681 agaaggattt cgaggacgta tttgaaaaat atgatgttat tgttggaccg actacaccga 700741 cacctgcgtt taaaatcggt gaaaacacga aggatccgct cacaatgtac gcaaacgata 700801 tcttaacgat tccggtcaac cttgccggcg taccgggaat cagtgtgcca tgcggattag 700861 cagacggact tccgctcggc ctgcaaatca tcggaaaaca ctttgatgaa agcactgtat 700921 accgcgttgc tcatgcattt gaacaagcaa cagaccatca taaagcaaaa cctgaactgt 700981 aaggggtgaa aagaattgaa ctttgaaacg gtaatcggac ttgaagtcca cgttgagtta 701041 aaaacaaaat caaaaatttt ctcaagctct ccaacgccat tcggcgcgga ggcgaatacg 701101 cagacaagcg ttattgacct cggatatccg ggcgtcctgc ctgttctgaa caaagaagcc 701161 gttgaattcg caatgaaagc cgctatggcg ctcaactgtg agatcgcaac ggatacgaag 701221 tttgaccgca aaaactattt ctatcctgac aacccgaaag cgtatcagat ttctcaattt 701281 gataagccaa tcggcgaaaa cggctggatc gaaattgaag tcggcggcaa aacaaaacgc 701341 atcggcatca cgcgccttca tcttgaagag gatgccggaa aactgacgca tacgggcgac 701401 ggctattctc ttgttgactt caaccgtcaa ggaacgccgc ttgttgagat cgtatcagag 701461 ccggacatcc gcacgccgga agaagcgtac gcatatcttg aaaagctgaa atccatcatc 701521 caatatacag gcgtttctga ctgtaaaatg gaagaaggct cacttcgctg tgacgccaat 701581 atctctcttc gtccgatcgg ccaagaggaa ttcggcacaa aaacagaatt gaaaaacttg 701641 aactcctttg cgtttgttca aaaaggcctt gagcatgaag aaaaacgcca ggagcaggtt 701701 cttctttccg gcggcgtcat ccagcaagaa actcgccgtt atgatgaagc aacgaagaaa 701761 accattctta tgcgtgtcaa agagggatct gacgactacc gttacttccc agagccagat 701821 ctagtcgagc tctacattga tgatgaatgg aaggaacgcg taaaagcaag cattcctgag 701881 cttccggatg agcgccgcaa gcgttatatc gaagagcttg gcttgcctgc atatgacgca 701941 atggttctga cgctgacaaa agaaatggct gatttcttcg aagaaaccgt tcaaaaaggc 702001 gctgaagcta aacaagcgtc taactggctg atgggtgaag tgtcagctta cctaaacgca 702061 gaacaaaaag agcttgccga tgttgccctg acacctgaag gccttgccgg catgatcaaa 702121 ttgattgaaa aaggaaccat ttcttctaag atcgcgaaga aagtgtttaa agaattgatt 702181 gaaaaaggcg gcgacgctga gaagattgtg aaagagaaag gccttgttca gatttctgac 702241 gaaggcgtgc ttctgaagct tgtcactgag gcgcttgaca acaatcctca atcaatcgaa 702301 gactttaaaa acggaaaaga ccgcgcgatc ggcttcctag tcggacagat tatgaaagcg 702361 tccaaaggac aagccaaccc gccgatggtc aacaaaattc tgcttgaaga aattaaaaaa 702421 cgctaataaa aaagcagccc ttagaggctg ctttttttat ggtcaaattg agataaagac 702481 aagatgaggg cccgaagcct ttcaacttct ttgtcgttgg ttccggccaa attggacagc 702541 atgcctttaa taatcggctt gcgcggttta tcctgagtca attcttcctc gataacatca 702601 agtgacacgg tgatatcctc gggcagcgtg ctgttttctt tcactttctg aatgtcctca 702661 agcagctggt cttttcccgc aggcatcggg ttaaaaatgt cttttgatac aatcggattg 702721 agtgcagaac ggctcagccc ctgtacaaga tcatccagtc tctcaataat aaaggctgag 702781 atttcttctg catcgatatt aagctcaccg ttaaatacca tcacgttcat ataggaatgc 702841 acaatgcctc ttgccatgat ggacagatct gcgacatacc gctcgattcc ttcgccatag 702901 gataccagca aggcgttccg gtacagctta tccgtctcca tggttacttt gtaaaagtat 702961 tgcttgattt cttgattttc cggaatgata ttttcggtaa gcaaaagaac gataaaatct 703021 ttatgatcgc gaaaatcctc aaattgagcg ccaatttgct tttttaacac ttccttaggc 703081 ggctttccgg cgagatcttc ttctatattt ttcattttgt tcatagacat accgatataa 703141 tattcacagg cagataacag cagcgcttct ttcgatttga agtgcaaata aaaagcgccc 703201 ttcgaaatgc cgcattcact ggcgatttct tggatcgtcg tagctgcgaa tccttttttc 703261 gcaaataaac gaatgctggt ttttatgatt ctctcttttt tttcattcat gacgtgcttc 703321 cccttaatcc ttgaaaaatt tagtaaaatt ttctggtata tgagttgacg ttgttgcgtt 703381 ataacgttta gtattatata gaatgaccag tcagtcaata aaaaatgtaa tggaggatat 703441 gatgaaccac gttattaatt tcgttctgaa aaacaaattc gccgtatggc tgatgacgat 703501 tattgtaacg gcagccggct tgtatgcggg tatgaatatg aagcaagagt ctattcctga 703561 cgtgaacatg ccttacttga cgatcagcac gacatatccg ggtgcaacac caagccaagt 703621 ggctgatgaa gtgaccaaac cggttgaaca agccgtacag aacttggacg gtgtcagcgt 703681 tgtgacgtcg acgtcctatg aaaacgcatc gtcggtcatg attgaatatg attatgagaa 703741 agatatggac aaagcgaaaa cagaagcagc tgaagcgtta gaaaacgtca acctgcctga 703801 tgacgcgaag gatccggaga tttcacgcta cagcttgaac tcattcccga ttctgacgct 703861 gagcgtgtcc agtgataaag ataatctgca agagctgacg aaacaagtgg aggacagcct 703921 cgtttctaag cttgaaggca tagaaggcgt tgcgtccgtc caagtatcag gccagcaggt 703981 ggaagaggtt gaattctctt tcaaagaaga caaactgaag gaatacggcc ttgatgaaga 704041 tacagtcaag caagtgattc aaggttcaga tgtgacaact ccgcttggat tgtacacatt 704101 cggaaatgaa gaaaaatctg tcgtcgtcag cggcgatatt gaaacaatta aagatttgaa 704161 gaatatgaga atcccgacgg catctgcttc aagtgcaggc agcagcgcag catctcaagc 704221 aggtgcgcag agtgctcaag cagcccaaag cgcgcaagcg gcagcacagg tgcagcaaag 704281 cgcaagcaca gcagtgccga cggtcaagct ttctgacatt gctacaatta aagatgtgaa 704341 aaaagctgaa tccgtttcac gcacaaatgg caaagacagc atcggcatca acatcgtcaa 704401 agcaaacgat gcgaatacgg tagaggttgc cgacgatgtc aaagctgagc tgaaaaagtt 704461 caaagaagac cataaaggct tcaattacag cgcaactctc gacatggcgg agccgatcac 704521 acagtcagtt gacacgatgt taagcaaagc catcttcggt gctatttttg cgattgtgat 704581 tattctctta ttcttaagag atatcaaatc aacattaatt tctgttgttt caattccatt 704641 atcattgctg atcgcactcc ttgtgctgca gcagcttgat atcacattga atattatgac 704701 gctcggcgca atgaccgttg ccatcggacg tgtagtcgat gactccatcg ttgtgatcga 704761 gaacatttac cgccgcatga gactcaaaga tgagccgctc cgcggaaaag ccttggttcg 704821 tgaagcgacg aaggaaatgt ttaaaccgat catgtcatca acgattgtga caatcgcggt 704881 attcctgccg ctcgcacttg taggcggaca aatcggtgaa ttgtttattc catttgcctt 704941 aacgattgtt tttgcgcttg ccgcatccct agtgatttca atcacgcttg tgccgatgct 705001 cgcacacagc ctgttcaaaa aatcattaac cggtgcgccg attaaagcga aagaacacaa 705061 acctggcaga cttgcaaaca tctataaaaa agtattgaac tgggcgctga gccacaaatg 705121 gatcacgtct atcatcgcgg ttctgatgct ccttggaagc ttgttcctcg taccgttaat 705181 cggtgccagc tacctgccgt ccgaggaaga aaaaacgatg cagctcacat acagcccaga 705241 accgggtgaa acgaaaaaag aagccgaaaa tgaagctgaa aaagcggaaa aaatcctgct 705301 tgaccgcaag catgtcgata cggttcagta ttcattaggc tctggcagcc cgcttgccgg 705361 aggagattct aacggtgcgt tattctatat caaatatgaa agcgacacac ctgactttga 705421 taaagaaaaa gataacgttc tgaaggaaat ccaaaagcaa tctgaccgcg gagaatggaa 705481 gtcacaggac ttcagctctt caggcaataa taacgaatta acatactatg tgtatggcga 705541 ttctgaaaac gatattaaag acacggtcaa agacattgaa aaaatcatga aagatgaaaa 705601 ggatctgaaa aacgtaaatt caggcctttc cagcacatat gatgagtaca catttgtcgc 705661 tgaccaagaa aaactaagca agctcggttt aaccgcgtct caaatttctc aggccttaat 705721 gtcacaaaca tcgcaagaac cgctcaccac tgtgaaaaaa gacggcaaag agcttgatgt 705781 gaacattaag acagaaaaag acgagtataa gagtgtgaaa gatttagaga ataaaaagat 705841 cacttccgcg actggccagg aagtcaaaat cggcgatgtg gcaaaagtga aagaaggatc 705901 aacatcagat accgtgtcaa aacgtgacgg aaaagtctat gcagatgtca caggtgaggt 705961 tacctctgac aacgtcacag ccgtatcagc tgctatccag aagaaaatcg ataagcttga 706021 ccaccctgat aacgtatcga ttgacacagg cggcgtatca gcggatatcg ctgattcctt 706081 cacgaagctc ggtttagcga tgctggcagc aatagcgatc gtttaccttg tgctcgtgat 706141 taccttcggc ggagcactag cgccatttgc gattctgttc tcattgccgt tcacagtcat 706201 cggtgccctg gtcggacttt acgtatcagg tgaaacgatc agtctgaacg ccatgatcgg 706261 tatgctcatg ctgatcggta tcgttgtcac gaatgccatt gtcttaattg accgcgtgat 706321 tcataaggaa gcggaaggcc tgtctacgag agaagcgctc ctggaagccg gctctacacg 706381 actccgtccg atcctgatga cagccattgc gacaatcggc gccttgattc cattagccct 706441 cggcttcgaa ggcggaagcc aggtcatttc aaaaggactc ggcgtaacgg ttatcggcgg 706501 tttaatcagt tcaacgcttc tgacgctcct gatcgtgcca atcgtatatg aagtattggc 706561 gaagttccgc aagaaaaaac cgggaacgga agaagagtaa aaaacaaaaa gcctcagctc 706621 tgctgaggct ttcagcttgt tgaaaaaccc tcgcattcgt tgtcaggtct gcgcgtcggt 706681 gctcacgaat tctacattcg ctccgctcca atgctccccc ttcctagact acaagggttt 706741 tcaatcaagc tgaaagaatg ttaaggatga caaaagctca aaacaagaat cagttttgag 706801 cttttgtgcg ttttcacctg taagattatg tacattttgt tgcgattttt ttaactcata 706861 gtataattaa aggttgttag tgtaaaaatg gatcggatac tcttaagtag gatgatgaga 706921 taatgaaacg tgcacgcata atatacaatc cgacttcagg acgggagatc tttaaaaagc 706981 atcttgccca ggtcctgcaa aaatttgaac aagccggcta tgaaacctcc acccatgcga 707041 cgacatgcgc aggagacgct acacacgctg ccaaggaagc ggcattgcgt gagtttgacc 707101 tgatcattgc ggcaggcgga gacggaacga tcaacgaggt cgtcaacggg cttgcgcctt 707161 tagacaatcg tccgacactc ggtgtgattc ctgtcggcac aacgaacgac ttcgccagag 707221 cgctcggaat cccacgcgag gatattttaa aagcggcaga tacggtcatt aacggcgttg 707281 cccgcccgat tgatatcgga caggtcaacg gccagtattt tatcaatatc gccggcggag 707341 gccgtctgac ggagctgacg tacgacgtgc caagcaaact gaaaacaatg ctcggccagc 707401 ttgcttatta tttaaaagga atggaaatgc tgccttcact tcgtccgaca gaagtcgaga 707461 ttgaatatga cggcaagctg tttcaaggtg aaatcatgct gtttttggtc acgctgacaa 707521 actccgtcgg cgggttcgaa aagctcgcgc cggattccag cctgaatgac ggcatgtttg 707581 atttgatgat actaaagaaa gcaaaccttg ctgaatttat cagggtcgcc acgatggcgc 707641 ttcgcggaga acacatcaac gaccagcaca ttatttatac aaaagcgaac cgcgtgaaag 707701 tcaatgtatc agaaaagatg cagctgaacc tggacggcga gtacggcggc atgctgccgg 707761 gcgaattcgt gaatctgtac cggcacattc acgtcgtcat gccgaaggag aaagcggaac 707821 agttggatga ctaaaacttg gcttggtaag ccaagctcag aatgttgaca aaatcctaaa 707881 acagttttcg ttttaggatt ttgtcatctt ttcagcgtga ttgaaaacct ttgaagtcta 707941 ggaagggcga gcatcggagc acagcgaatg ttgaattcgt gagcaccgaa gcacaggcct 708001 gacaacgaat gcgaaggttt gcctacacgc tgaaacttgg cttgaatagg ccaagttttt 708061 ctttcgctta aaactagagg tgattataga tgaaaatgaa acccccagta gaaaaaaatg 708121 aatactacga tgtgacattt gaggatttga cacatgaagg agcgggcgtc gcaaaggtcc 708181 aaggcttccc gatctttgtg ccgaatgccc tacccgagga aaaagcccaa atcaaagtga 708241 cacgcgtcaa aaaagggttc gccttcggcc gcctgattga gctgaaggaa gaaagcccgc 708301 atagaacgga cgccccatgc ccgatttaca aacaatgcgg aggctgccag cttcagcaca 708361 tgacctacga aggccagctc ctgtttaaac agaaacaagt caaagacgtc ttagaacgca 708421 tcggcaagct ggacctttca aaagtcaccg tgcacccgac actcggcatg gaagacccgt 708481 ggaactacag aaacaaagca caggtgccgg taggagaacg ggaaggcgga ctcgtcgcgg 708541 gattctatca gcaaagaagc catgacatca tcgacatgag cgcctgcctg atccagcaat 708601 ccaaaaacga cgaagccgtt caagctgtca aagacatttg cgcaaactac ggtgtcaaag 708661 cctacaacga agaacgccac aaaggctggc tccgccacat catggtcaga tacggcgttg 708721 ttacgggcga aatgatgatc gtcttcatca caagaacaag cgacttcccg cacaaagcga 708781 agatcatcga agacatcaca gcgcaattcc cgcacgtcaa atccatcgtg caaaacatca 708841 acccaaacaa aacaaacgtc atttttggca acgaaacaaa cgtcatctgg ggcgaagaat 708901 acatctacga cctcatcgga gacgtcaaat tcgccatctc cgccagatcg ttttatcagg 708961 tcaacccaga gcaaacaaaa gtgctctacg acaaagcgct tgagtacgct gagcttcaag 709021 gggaagaaac cgtcatcgac gcttactgcg gcatcggaac gatttctctc ttcctggcaa 709081 agcaggcgaa aaaagtgtac ggtgtagaga ttgtgccgga agcaattgag gacgcgaagc 709141 gaaacgccga attaaacggc aacacaaacg cagagtttgc tgttggagaa gcggaaaccg 709201 tgattccaaa gtggtacgaa gaaggcatta cagctgatac gctggtcgtc gacccgccaa 709261 gaaaaggctg cgacgaagcc ctcctgcgga caattgtgga gatgaagccg aagcgggtag 709321 tgtatgtgtc ctgtaatcct ggcacgcttg cgagagattt gcgggtgctt gaggatggcg 709381 ggtacgtgac gcgcgaagtg cagcctgtgg atatgtttcc gcatacgaat catgtggagt 709441 gctgtgtgtt gataaaatta aaagaataaa tagtcaaaaa tctatgctga tggaactgtt 709501 ggttctctaa aacgataatt gatttcaatg gttccatttg catgtacttc tatttcatct 709561 actaacaaat gaagcatttc gggggtaagt gtaccttcct tcatgaattt atctaagctc 709621 tttttaaaat caattatttc tttttcaatc ttttgaaatt ctaggtcctt agatagttgg 709681 tgaagggtag tttcaaaatt tgaaatatct tcattggtga tatttatggc taattggtaa 709741 tcttctttag atataacacc attagcaaga gagataacta aattggattt atctctcttt 709801 ttatcgttta atttttcatt aatttcgatt atcttagatt cgattttttc tttgtacttt 709861 aacgcttttt cacttaattc tttaaaataa ttttccttac tgaatttcaa atatatctta 709921 tttaggttgg ttattacttt atcagttaaa tctatttcac ttacgtaatg atcactacat 709981 gcttttaaac catgtttatt ataacttcca caaacataac cttttcgatt ctttttaaaa 710041 tgcattgacc tcctgcaatc tttgcaaacc gcagtatttg taaagagatg tacttcagct 710101 tgaggtctcc ttctttttct agttattaaa atctcttgta caataagaaa gtcttctaaa 710161 ggtatgattg gttcgtggct tttttcaata attatttggt tttctaggtt aactgacctt 710221 cttcttttac tggtaacact cggtctatat tctctacatt gttgtagtgt cccagtatag 710281 tgaggatttt cgagaatttt tcttattgaa gatccgtgcc atttgtcagt agcgttcttt 710341 ttgcgggcaa gctgcgaggg actagtgacc ccttcgttat acaatcccct tgctattgca 710401 tcaaagcctt ttccagcaat atattctgaa aagattctaa tatttactat tttctctgcg 710461 tttgctgaat ttgagagaga tatgattgta gaacgaactc aagaaggtaa aatgttggcc 710521 aagcagaatc cggatttccg agaaggaaga cccaaaaagt tcacaaagca gcaaatcaat 710581 catgcattaa cattactaga aaatcattcg tataaacaag ttgaagatat gactgggata 710641 tcagtttcta cacttgtaag agctaaaaag aagaaagctg ctgaagctat aaatggataa 710701 atattgtgaa ttaattattc aatatcttga gaaattttta taaaagtaat caaaagttta 710761 atgggggaaa cgaaatggcg ctcattgatt tagaagataa aattgctgaa atagtgaatc 710821 gagaagatca ttcagatttc ttgtatgaat tactcggtgt atatgatgtt ccacgagcta 710881 caattacgcg cttgaaaaaa ggaaatcaaa accttacaaa acgggttggt gaagtacact 710941 taaagaataa ggtgtggttt aaggaggcta agaaaggaaa gctctttgac gcccttattg 711001 atatagaaca acaagttgaa tatctttcag ctaagccacg atatttatta gttactgact 711061 atgatggagt attagcgaaa gatacaaaaa cattagaggc tcttgatgtt aaatttgaag 711121 aacttcctca gtatttcgat ttcttccttg cttggaaagg tattgagaaa gtagagtttg 711181 aaaaggaaaa ccccgctgat attaaagcag ccgaacgttt tgcacggata tatgatgtac 711241 ttcgtaaaga aaacaatatt attgagacta atagagggtt agatttattt cttattcgtt 711301 tactgttttg ttttttcgca gaagatactg acatcttcaa acgaaatagt tttacgaatt 711361 taattaagac tttgactgaa gaagatggtt caaatctaaa taaattattt gctgatttat 711421 ttatcgtgtt agataaaaat gaacgagacg atgttccatc ttatttaaaa gagtttccgt 711481 atgtaaatgg ccagttgttt actgaaccac atacagagtt ggaattttct gccaaatcca 711541 gaaagttaat tattgagtgc ggtgaattat taaactgggc taaaatcaat cctgatatct 711601 ttggttcaat gattcaagct gttgcttctg aagaaagccg tagttattta ggtatgcact 711661 acacaagtgt ccccaatata atgaaggtta ttaaaccgct tttcctagat aaacttaatc 711721 agtctttttt agatgcatac gatgattata caaaacttga aaatcttcta acacgaatcg 711781 gcaaaattaa attctttgat cctgcatgtg gttcagggaa ctttttgatt attacctaca 711841 aagaattacg gcgtatggaa atcaatatta taaaacgact tcaagaactc ttgggagagt 711901 atctttatgt accttcagta actttatctc aattttacgg aatagagatt gaagattttg 711961 cacatgacgt tgcaaaatta tcactttgga ttgctgaaca tcaaatgaat gaagaattaa 712021 aaaatgaagt tcataatgca gtacgcccaa cgttaccact tcatacagca ggggatattc 712081 gttgtgcaaa tgctattagg gttgagtgga ctgaggtttg tcccgcacaa ggatctgaag 712141 aagtatatgt ttttggtaat ccaccgtatc ttggttcaaa aaaacaaaac aaagaacata 712201 aatctgatat gttatcaatt tttggaaaag tcaagaatgg taaaatgctt gattatattt 712261 ctgcttggtt ttactttggt gctaaatacg cttcaactac aaatgcaaaa gttgcctttg 712321 tatcaacaaa ttcagttact caaggggaac aggtttctat cttatggaat gagttattca 712381 agtttggaat tcaaatcaat tttgcctata aatcttttaa atgggcgaat aatgctaaaa 712441 ataatgctgc ggtaattgtt gtgattgtag gttttggccc gttagatacc aaagtaaaca 712501 agtatttatt tgttgatgaa acgaaaaagc tagtttctaa cattagtccc tatttaactg 712561 atggtgaaaa tattcttgtt tcttctagga cgaagccaat ttcagactta cccaaactgc 712621 attttgggaa catgcctaat gatggcggag gattactctt taccattacg gaatatacag 712681 acgcaatcaa taagtatcct gaattagttc cctattttaa aaagtttata ggttcagtag 712741 agtttattaa tggtggttta cggtattgtt tatggcttaa tgaagcaaaa tatgaaaaaa 712801 taaagtctaa tcctctaata caagaaagaa tctcaatttc aaaaaatcac agggaaaaat 712861 caacagataa aggaacgaat aaacttgcat taactccgtg gaagtttaga gatactcatg 712921 aaacaactaa ttattccatt gttgttccat ctgtgtcttc tgaaaataga ttttatattc 712981 caatgggatt agcaggtgca gatacaattt tgtcaaatct aatttatgta atttacgatg 713041 cagaaattta ccttctaggc attttgatgt cacggatgca tatgacttgg gtaaaagctg 713101 tagccggaag attaaaaact gactataggt actctgcagg tttatgttat aacactttcc 713161 ctattcctga attatcaaca agaaggaaga atgaaattga agaagcaatt cttgaaattc 713221 ttgatcttcg tgaagagcag ggtggtacat tagcagagct ttataaccct tcaacaatgc 713281 caattgaatt aaaagtagca catgaaaagt tggatggaat tgtagaaaga gcgtatcgtc 713341 aaaaacaatt tgaatctgat gaagaacgct tagaagtatt gcttaaattg tatcaagaaa 713401 tgacagaacg gtaggtgtaa ggtgtatgga aaatataatt gaaattaatt ataaccaaac 713461 tggtaaaagt aagaaaacaa atgaatacgg tatgcgtgaa atgcaggcaa gagcttttga 713521 aaaacgtaac tcacaatatc tcttagttaa agcaccgcca gcttctggga aatctagagc 713581 tttaatgttt atcggtttgg ataagctcat aaatcaaggt ttgaggaaag tgattgttgc 713641 tgtacctgaa cgctctatag gttcttcatt taaaaatacg gatttaaaaa gttatggttt 713701 ctttgaaaat tggaaagttg atcctagaaa taatttaact gttggcggag ataactctaa 713761 ggttaaatct tttgttcgtt ttatggaatc ggacgatcag gtgttaatat gtacgcactc 713821 tactttgcga tttgcgtttg aaaaaattga tgataaagca tttgataatt gtttacttgc 713881 aatagatgaa tttcaccatg tatcggcaga tgtcaattct cgattaggtg aattgttaag 713941 aagtattatt cataattcat cagcacatat tgtagcgatg actgggtcgt atttccgtgg 714001 agattctgta ccaattttat taccagaaga tgaggaatta tttgacaagg taacttattc 714061 ctattatgaa caacttgatg gatatgaata tctaaaggga tttggtatag gatatcactt 714121 ctatcaaggc cagtacacat cagctattaa tgaagtattg gatacaaata agaaaacaat 714181 cgttcatatt ccaaatgtaa actcagggga atcgacaaag gataagtacg atgaagttgg 714241 taagatactt gatatgattg gtgaagttga atatcaagat gatgatactg gaattattta 714301 tgttaagcga cattctgacg gtaaaacatt gaaaattgca gatttagtag atgaccaagt 714361 tggaagagaa aatgtcgttg cgtatttgcg taatattgaa gccctagacg atttagatat 714421 aattattgct cttggtatgg cgaaagaggg ctttgactgg ccgttttgtg aacatacttt 714481 gacagttggt tatcgtggct cacttacaga aatagtacaa ataattgggc gctgtacacg 714541 tgatagttac aataaaacct atgctcaatt taccaaccta atcgcaatgc ctgatgcaaa 714601 ggatgaagta gtgacttata cagtgaatac aatgcttaaa gctatttctg cctcactttt 714661 gatggagcag gtccttacac ctgactttaa atttaaacgt agaagaaatg aaagtgaaaa 714721 atcttctact acaggagaat tattcgttaa gggattgaaa gaaccatcaa cagaaaatgt 714781 caaaaagatt attgaaaatg atattaatga tttaaaagca aaaatcatgc aagattcaca 714841 agtccaaaaa acatttagtg gagaagtaga tcccaaagta ttgaacaaag tgttgattcc 714901 gaaagttatt caaaaagtat atccaaattt atcagatgag gaaattgagg aagttagaca 714961 gcacgttgtt ctagatacag ttatgaaagg tgctaagtct gaagttgtag gaagtaaaga 715021 atttataaga atggcagata agtttataaa cattgaggat ttagatatca atctgattga 715081 ttccatcaat ccgttccaaa aagcatttga ggttctatcg aaagaattga actcaccagt 715141 gctaaaactg attcaggaaa ctattgatgc aaaacgtatt aattttgatg aagatgaact 715201 agtattcata tggccaaagg tttaggaatt ttatcgttca actggtagaa gacctgattc 715261 aaaatctgaa gacccacttg aaaggcgtat gggtgaagct gtattataca tgcaagagct 715321 taggaggaaa cgtgaaaatg gcaagtaata gataccattc tattaatgaa atcatggaaa 715381 gtcagctgtt ttaccaaatc acaacaccac ctaagaaaac acaaaaagcc cagtatgatc 715441 ctgaagttga aaagtttttg gagattattg aattcgtcaa agaaaatggg cgagaacccc 715501 aaaaagtccc tactgattta actgaaagaa gtttagcaag tcgattaatt gggattcgga 715561 aagatcctga tcgtatggaa tatttgaaag agtatgatga aattggatta cttgaagtaa 715621 gatcgaagga actaacaatt cctaaaattt cttcaattga tgatattcta aaaagtggct 715681 tatctgcatt attaggtgat aatttaaata atgatataac taggtcaatt tttgatacaa 715741 gttcacttca aaaggttacg acaatgcctg aatacgttgc aaagcgtaaa aaaataaaag 715801 attttggaaa gtttgaagag ctattcaaga agtgccacaa ggaaattaca gagggtaaac 715861 gaaaaatttt aactttcaaa aatgaacaag acatacagtc aaatagtttt tatatattaa 715921 aaggagttct tctttatgtt gaagatgtgg gagaacgtaa aaaagcaaag ggaaaaacca 715981 atgctagact tcgatgtata tttgaaaatg gaacggaatc agatatgtta ctacgttcct 716041 tatcagcgga gttatataaa catggtagac gtgtgaccga caatgaagat acattgttgg 716101 ataatgttag agaagatgat gtttcgactg gctttattta cgtactaaaa tctttgagta 716161 cagatccgca aattagttcc attaagaatt tatataagat cggttttaca actggttcag 716221 tagaaaatag aatcaggaat gcagaaaatc aatcaactta tctttatgct ccagtagaaa 716281 ttgtaaccac atatcaagtg ttcaatatga atgctagcaa atttgagacg gcaatccatc 716341 atgcgctagc aaataataat ttggatgttt ctattttggg ggcaaatgga aagatgttag 716401 ttcctaaaga gtggttcgtt gtcacacttg aagatttaca agctgtaata gatgagattg 716461 tgatgatggt tcatctttat gactaaatta gtatattagg attttagtat taataataat 716521 tttatagtag actatgaaaa aatttgatgc cataacaata acttgttccg ctttggagtt 716581 tgtcacaatt gtagaattat gtgttgcgag tattaatagg aaggggttga gcgaccgcaa 716641 aaaaaatttt cggtgctgtc cgcaaaaggg agtttgggtg ttttgcgtta tatttggttg 716701 tgtgaaggtt agcggaaact caattcgtga agttaggatt gcggttatta cgactgagta 716761 gtttcgtcat actcttttag cagtttttct gtcttatgca tttctttgag catcggattc 716821 atgtagtcgt tagctgattc tagatatgct ctcgtcagag tgtctagttt atttctaact 716881 ttagagaggt cttcttcgaa ttttccatcc gatgattgaa ggataaattc ttttgcctct 716941 tcatatcttt ttaatatgtt tttcaccatt ggagttggat tcttttgatt tattgttttt 717001 attacagtga ttgttaaatt tatttgtttt attaattctt ttcttactgt caaggtgatg 717061 ctccttttaa atctctattc tatttgagag ttgctatatc tgtttaatgg tttgatagac 717121 tactcatctt tataatttag agcaattttt acaacttgtt ccgctgtgta atcttcattg 717181 ctccagaaaa ttaaatcact tggtgccgga taaggaacat ttttctctaa taaatcgaga 717241 tattcactga ctttctcatc atctaatgtt gggttcatta attcctttac aagaaagatc 717301 aactcttctt ttgtcagttt atccattgtt tgccctccaa tagattgtat ctccattgat 717361 tttacaaatg actttatttc ttctgataat gttataggtt gtttgcataa tgatagataa 717421 ttgtcttgag aaaagttagt ctcattatag agtttattaa ttgtatttat aacaatatat 717481 tcatatggaa aacctctaaa atatctttat tttagattgg tttataaaaa atagctcagc 717541 agagtagggc tgagccattt tttaattata gaccgaggta actaattaca aattctttat 717601 catcctcatc ttcaggcaaa ataccaaggt ttttatattc ccatattgcg attctttcat 717661 atccatctaa ttctgaggct aaaatatcat cataattata atctaattgg aattctccgc 717721 tacgatccaa tgttagtgta aggttagtcc aaacatcatc gttattattt ctgtgttcag 717781 ttcttaattc ttcaaaaagt tctcttagtt ctcttaacaa cgtcttgaaa atatccttgc 717841 ttacgttgta atggctaggt atatcttgtg aataaataat ttgattattt tctggtgttc 717901 tgaaatgaaa aagaaccatt gtggaatcat ctaatacttc tgcataaaga tatatctttg 717961 tccattcacc aggtatgatg tcattgagtt tttctccaat aagttgatac aaatcttgca 718021 tcttcctagt ttccattctt ctaaccccca ggctgatttt taatagagac gcttatttct 718081 tttctgctcc caattttgta ggttacatcg aaatatgatg gtctaagtga atccccagaa 718141 tagactggtt ctatttgaac tgctactttt ttaggtggtt ttttgcttag ggcttttgcc 718201 cactcctgct ccatctcata ccatttccca ccgctcctat taatctgaga attcatcggc 718261 acgatattgt caaactggcc tgagcctttg aattgggtgg cgattaaatg gccgccgtca 718321 tcgtcaggct ttcggtcctg gggctttcca gcattcgttt gtgcatattg gtttcgtttc 718381 gcttctccca gctgcaagtc tgctttgaca cttgtaattc taccatagtt gtcagtcgtg 718441 tacgtgtagc cttcttttgt tttgtagatg atattaggct tcagcacttt ctttctgctc 718501 catcttgcga aatgctcgcc gtatttgacg gttaccggcg gtacatgtgg cgctggagtt 718561 cgtcttccgc ttgatgacgt tccgtatggt ttcggcagga tgaccttggc gaatttttgc 718621 agtccttctt taagcgtgac cccgttgact gcgttgtaag gaacgcctgc cggcactaaa 718681 tcatgacggg gatgatacgg gagaatatcc gcaagtgtga gatctccgat ttgatttaac 718741 ttggttttga cgtgtttttt tgatacttca atgcctgtgt ttactttttg tttgatgtga 718801 tcaacggttt gttttgagac tgttatggct ttttgggctg ttgctgattt gcttgctgct 718861 gttttgactt tggtcgtcac tttggcggct gtgccagttt ttgagacggc tcctacgcct 718921 tttgtgccga caattgatgt gacaacagtg ccaaccgcat atgacaccca tcttgctctt 718981 gagtaggtgt caccattcac catgtctttt tgatacgatt cttcgattgc cgctgaaatg 719041 gcttcatacg ttttgatcgg gtgagccatc gctccggtaa tcgcttcaac ggttcctccc 719101 ggatctgtga ccatatccca caggcctacg accgcgtctt tcccggaatc ataaaggccg 719161 acggcaaccc ctttgaagcc tgcttcaagc tcacgcgtgt tttcaatttg ggtgaagtat 719221 ctctgttgtt cagctgtcag attttcatag ccgatcgttt ttgccatttc gtagaattca 719281 tcggcatctg cataatcgta gtttttcagt ctttctttca gtttctcaat ctcgcgttcc 719341 ttcgcttcct ctttcttaat cttcaagtaa gcctcagtcc gcttttcaat gtcgcctttt 719401 ttcttatgta tgtcactctc acggtacgcc ttggcgttgt agtggatggg tgtggcgttt 719461 ttgcctttac ccgttgcttc ttggagcttt tggaagtcgg atttgatgaa ttgttcgttt 719521 ggttcagaca gggcgtattc tgttttcagg tcttcgtcca aggcgtccaa tttttccagt 719581 gtttttttgc gtttgtcgtt ggcatcggcc agctcgtctt tgaaggtttc tgttgaaaac 719641 aggtcgagcg ggaggatgtc gtcgatatcg tttaggatgt ctttcatcgc ttttttctgt 719701 tcggacatga tggatttaga ttttttattg gcatttgcca gttcgtgctc caggaaggat 719761 tcttcgatgt atgcgtctga gaggcctttg tcttcggcgg ctccggcgat gctgttgaaa 719821 aatgcgattt tcatgtcgat gtagtcgatc cactggtcgg cgacgccgac gtggtcgtga 719881 tagaatgcct tgatgttgct ggcgcctttt cctgagaatt cactgtcact gagatcagcg 719941 actcctttta acgcttttct caagttgacc atttgcgttc ttagttcttt gtactctttt 720001 gcacggtctg tcgcttccga aagcagtgtt ttcgcttcaa atactttcat gaccatttcc 720061 cttcttttgt tcgctcaata tcaaaatttt accacgggtc gggataaggt gggggtgaga 720121 acgtgttttg gtggaaaaat gagtcatttg gcatgtgtct ttattcgtgg agggattgga 720181 ggaaacatgg tcgaaatgat attgattgct acacattttt tggaagtttg tattctatat 720241 tgttttttaa ggagcatgtt gatgacgaaa aaacggatta catttggttt attagtttta 720301 atggtatgtg tcatcctgtt tgttctgtat gttcagttac gcaataaaga tagtattcct 720361 gtccaatctt ccgccattca ccccgaagaa gaccgcatct tttttattta ctccaatcct 720421 ttcataaaag aaagcgtgct gctttcaacc tctacaggcg aacggtttaa caggcgtacg 720481 tttaaggtgg cggatgtgcc ttatattcaa acgaaatctt atgcatcaac agaccttgta 720541 ttattggcgg aacacgagcc tttttactac acgctggaga aggatgtgat caaagagcat 720601 ccgctgtcag atccatttgc gttttggtat gaggggaagg atgtcactat tgaggcctat 720661 aatgttgata cgacgggaaa tgagatccac ataaacgaca gaaaaacgaa aaaggaatat 720721 acccttacct tgcctccgct tgtcacaatg ggggccagtg atgagaactt tatttatatc 720781 attcaaagca tgtctattta cgtgattgac agaaaaacag aggaaatgat tgagaccctg 720841 agcttagcct catacgctga tcaattcgca gactcggagg aatttatcgt cgcgagctcg 720901 gatcataaat tgactgtgat tgaaaaaggg acatggaaga cgacatatat tgcgtatcct 720961 gaagatcttg aatatgcaga tactgtgtac tatgacaaag aaagcggcag tttttacgtg 721021 gcgtacgagg acaaagaggg tggagcgaac ttgctggaat atggggagga tttttctatt 721081 cacacataca gcttgaaatt cccttatatg gaggcgaagt ttaaggggaa tctattgtat 721141 atagttgccc aggaagagca taaaaagggc atcggcggat acgtgggtgt gtttgatatc 721201 cattctaagg agatgcttta tcagtttgat ttgcctgagg aacaggtgaa ggttcaggat 721261 tttgttgtgg ttgacaataa gtgaatacta tatgaaatag aatgacaaag acccttgcat 721321 aaagggttct tttttatgaa aaaaacaaat tgacaggatg aaaaaacaat ttcttccttc 721381 tatattgttt tcaaaatttg ggattgatag aatatgacat atctcataga gaaggaggga 721441 agccgttgag tcaagccata ccgtcttcgc gtgttggtgt taagattaat gaatggtata 721501 aaatgattcg ccagttcagt gttccggatg ctgagattct gaaagcggag gttgagcagg 721561 acattcagca gatggaagaa gatcaggatt tactgatcta ttattctctg atgtgttttc 721621 ggcaccagct gatgcttgat tatttggagc cgggaaaaac atacgggaat cgccctacag 721681 tgacagagct tcttgaaacg atcgagaccc ctcagaaaaa actcacaggt cttttgaaat 721741 actactcttt gtttttccgc ggcatgtatg aatttgacca aaaagaatat gtggaagcga 721801 tcggatatta tcgcgaggcg gagaaagaac tgccgtttgt gtcagatgat attgagaaag 721861 cggaattcca ttttaaagtg gcagaagcgt attatcacat gaagcaaacc catgtgtcga 721921 tgtatcatat tcttcaagcc ttggacattt atcaaaacca tcctctatac agcattagaa 721981 cgatacaaag cttgtttgtg atcgccggca actatgatga tttcaaacat tatgataaag 722041 cgctcccgca tttagaggcg gcgctggaat tggcaatgga cattcaaaat gacaggttta 722101 tcgccatttc tctattgaac attgcaaaca gctatgacag atcaggagac gatcagatgg 722161 ctgtagaaca tttccaaaaa gcggcgaaag taagcagaga gaaagtgcct gatctgcttc 722221 cgaaagtctt gtttggatta agctggacat tatgtaaagc gggccaaaca cagaaggcgt 722281 ttcagttcat agaggaagga ttagaccata tcacagcacg ttctcacaaa ttttataaag 722341 aattgtttct gttcttgcag gccgtgtaca aggagactgt tgatgaacga aaaattcatg 722401 atcttttaag ctatttcgaa aaaaagaacc tgcacgctta cattgaagca tgtgcccgga 722461 gtgctgccgc tgtttttgaa agcagctgtc actttgaaca agcagctgcg ttttatcgga 722521 aagtgctgaa agcccaagaa gatattctaa aaggagagtg tttatatgcc tattaagaaa 722581 aaagtgatga tgtgtctggc tgttactcta gttttcggaa gcatgtcgtt tccaaccctg 722641 acaaactccg gtggatttaa ggaatcgaca gatcgaaata cgacgtatat cgatcattcc 722701 ccttacaaac ttagtgatca gaagaaagcc cttagctagg gctttttctt gctttacgga 722761 agacgttcca ttttccacat cgcggcattc cttctatttc taacgcaaga cactcgaaac 722821 aaccaaacca tttgaggtat aatggataaa gtgaataaca gtatttagat tgatatatat 722881 gaaagagagt ggaacatcat gggccgtaag tggaacaata ttaaagagaa gaaggcgtct 722941 aaggacgcaa atacgagtcg gatttatgcg aagtttggcc gtgagattta tgtggcggcg 723001 aaacagggcg agcctgatcc ggaatccaac caggcgctga aggttgtgct tgaacgtgcg 723061 aagacttaca gcgtgccgaa aaacatcatt gaacgtgcga tcgagaaggc gaagggcgga 723121 gcggaagaga attacgatga gcttcgttat gagggcttcg ggccgaacgg atcaatgatt 723181 atcgttgatg cgctgacgaa taatgtaaac cgtacggcgc cggaagtgcg tgcggcgttc 723241 gggaaaaacg gcggaaacat gggtgtgagc ggatctgttg cttacatgtt tgacgcgacg 723301 gctgtaatcg gtgtggaagg caaaacggct gacgaagcgc ttgaaatcct gatggaagcg 723361 gatgttgatg tacgtgacat tttagaagag gatgacagcg cgatcgtgta tgccgagcct 723421 gatcaattcc atgcggtgca agaggcgttt aaaaacgcgg gtgtcgagga atttacagta 723481 gcggagctga caatgcttgc gcaaagtgaa gtaacgcttc cggatgatgc aaaggaacag 723541 tttgaaaaat tgattgatgc attagaagat ttggaagatg ttcagcaggt atatcataac 723601 gttgatttag gtgagtaagg agtgagcagg ctgttatggc ctgctttttt tgtcccggaa 723661 attgttttag ctgtatgtag gcggccgcct atacgatcta taagatattc tcatactctg 723721 gactgtaacc tatgtgaagg agagagtaaa tatgactgat acaagacata tgtatggcgg 723781 acctggtttt ggtcattatc agggctttgg tattggccac ccgggctatg gcatgcaaag 723841 cacaggctat ccgggctatg gcatgtatgg aggccacccg ggctatggca tgcaaggcta 723901 cccagatcac ggcatacatg gaggagtcgg cggctatccg ggatatggtg ggtacggcgg 723961 ttacccaagc ggcggctatg gaggctctcc gggaactgga agctatccga gcatgcacca 724021 tgaaaatgat ggccatcacc actattatca ccatcatcat gatggaaaag ataatcttca 724081 tcaccatcat caccatgttg gaaaggataa tcatcaccac catcatgatg gtcattatgg 724141 ccaccatcat caccatatgg gccactgggg aaaagacggt tataaataaa gaagatgatg 724201 ataaaaagag gacactcttg cagatcaaga gtgttttttt agcttttttc ttgactgttc 724261 agtctggaaa atggtaacat ttgtttcagg aggtgatcat tttttgggga ggaataaaga 724321 atttgatacg gcgcttgttc ttcacagggc gatagaggtt tttggagagt atggctacga 724381 aggaacgtct cttcaggatc tgctctctca tttaggcatt gcgcgccaaa gtttgtatga 724441 tacgtatgga acgaagcgtg atttgttttt gtccgctgtg aaatcgtatc ttgaagggaa 724501 aaacgctgcc gttatggaaa ggcttgaagc gccaggatct gtaaaggaag ccattcgtga 724561 tatttttcag gagggtgtca atgccctgag ggatccggaa cgggcgaagg cgtgctacat 724621 tattaacagc gcgattgaac agatcccgca tgaccctgag cttgcccggt attttgaaag 724681 acaatccaag cagcttgagg acgcttttta tcacgggctt ttaagagcga aggatcaagg 724741 agaattgaat ggcgaagata ctgatatatc tgcgcttgct cggtacctga atcagagcag 724801 gctgtcactg acatttattg caaaagtgac ggcagatatg gatcggcttc aggaccatgt 724861 tgacgtgagt ttatcagtgc ttgattaaca tgtggtaaag gattctttgc ccatgtatgt 724921 actttttgga ctgaatagtc tagaaataaa aatgaggtga tgatgaatgt tgatgaatga 724981 gtttgaaaaa gcatgtgaaa cattgagaaa gtttatggct tatatgcttg agaaggacat 725041 gaagagctgg acggagcttt gggatgagaa tgctgtattt gagtttcctt atgcgccgga 725101 gggatcacca aaaagaatag aaggaaaagc ggccatttac gattatatta aagattatcc 725161 taagcagatt catctttctt catttaccgc tccgacagtg taccgttcag cagactcgaa 725221 tacggtgatt gcggagtttc aatgtgacgg ccatgtgatt gagactggac tgccttatcg 725281 ccaaagctat atcagtgtca tcgaaacgag agacggccgc attgtgcgtt atagggatta 725341 ttggaatccg cttgttgtaa aagaggcctt tggaggatca tttttgcaaa cagaggagag 725401 tgggaaatga tgaaacagaa tccgatttta atcacgggcg ggaccggcac agtcggcagc 725461 cgaatcgcca gccgtttaat aaagctggga tacagagtgc gtattgcaag ccggaaaaag 725521 ggcgcgcttg ctgatgctga gtatgtgtat tttaattgga agtacgcctc cagttttacg 725581 cctgctctgg aacaggtaaa acagatctat cttgttgctc cggtcggtgt atttgatccg 725641 gctccctatg tgcttccctt tttaaaggaa gcaaagcgtc tcggcgcaaa gcgggtagtg 725701 atgcaaagtg cgtctgttgt ctccgagaac ggtcccgtgt ttggcgcgct tcaccaggca 725761 gtgcgcgagt ttccagaatg gacggtgctg cggccctcat actttatgca aaatttcatc 725821 aatgtccagc accgcatgtc tattcaaacg gaggggcgca tcacaacggc ttcgggtgaa 725881 ggaaaacttg ggtttattga cgctgatgac atcgcagaaa cagccgtcag ggctttgatt 725941 gatgatgttc ctcatcaaac acatcatatt ctgacaggtc ccgaggcgct gagctatgcc 726001 gaagcggcgg agatcattgg agctgcggcg ggacgccggg tggagcatgt cagcatttct 726061 cgttccgagc tgcagcataa aatggaggca ggaggtttgc ccgcggatta tgcccatttt 726121 atggcgaagc ttgatgaggc aattagccat ggtgcggaac atcgggtaac ggatacagtg 726181 aagcgtgtga cgggaaaaga acctcgttcg ctgtcagagt ttgcggctgc tcatgctgca 726241 tattggacct cattttggac tgaatagtct agaaagacct tcggcgcttc cgaaggtctt 726301 cttattgaaa aagctaagtc gtgttttagt cataatcatg cctcctgcct catacctatt 726361 aaggtcattg tttttgagaa aggaggagcc ggaatgaagg atatgcagcc gtttacgcct 726421 gtcaaatcat atacgccctt tcacagccgt tttgatccct gtccgcccat agggaagaaa 726481 tattacagaa cgccccctaa cctttatatg acctttcagc ctgagcacat ggagcagttt 726541 tcgccgatgg aggctttgag gaaaggcacc ctttggaagg atctctatga tttttatgaa 726601 aacccttatc gagggggaga cgcacatggc aaaaaaggtt gacgccgaat attatcgtca 726661 gctagagcaa atacaggctg ctgattttgt gcttgttgag ctgagtcttt atttaaatac 726721 acatcctcat gatgaagatg cgttgaagca attcaatcaa tattccggct attcaaggca 726781 cttaaaaaga cagttcgaat cctcttacgg accgcttctg cagttcggca acagccccgc 726841 gggcaaggat tgggattggg gaaaagggcc atggccgtgg caagtataag gaggaatgcc 726901 tgaatgtggg tgtatgaaaa gaagctgcaa taccctgtca aggtcagtac gtgcaacccg 726961 acgctggcga agtatttgat tgagcagtat ggcggagcgg acggcgagct ggccgcggct 727021 ctccggtatt tgaaccagcg ttatacgatt cctgataagg tcatcggcct tttaacagat 727081 atcggcacgg aggagtttgc ccatttggaa atgattgcga ccatggtcta taagttaacg 727141 aaagacgcca caccggagca gctgcgtgaa gctgggcttg gcgatcatta cgtcaatcac 727201 gacagcgcgc ttttttatca taatgcggcg ggcgtgccgt ttaccgcgag ctatatccaa 727261 gcgaagggcg atccgattgc cgatttatac gaagatattg ccgcagaaga aaaggcgcgg 727321 gcgacgtatc aatggctgat tgatatttcg gatgatcctg atttaaacga ttccctgcgt 727381 tttttgcgtg agcgtgaaat cgtacactct atgcgcttca gagaagcggt tgaaatttta 727441 aaagaagaac gggataaaaa gaagattttc taataggcag attggcctct ctttcataca 727501 cccttttaca tacagagaaa atggtctgtt tttgcagttt ggtctgcatt ataatcaagg 727561 tgtgtgtgca agcttacttt ttgattggga ggcctttatg acagctttta agattgagaa 727621 cgaaacgatt gcagatggat tttacgcgtg tccggccgtc tatgaggatg cagaatcgat 727681 taccgggttg ctcgtccgaa cagctgaatg gctccgggat cggggttcta accaatggag 727741 cggacttctc aaagggcaag atatacatga tatcacgggg tcaattgaaa agggacatgt 727801 gtttgtgttt aaaaaagatg aagagcttgc ggctgtcgtg atgctgctgc ctgcaccgag 727861 cgagtgggac cggacgcttt ggggagacga tgggcatgag gagtccattt atttacaccg 727921 cctcgcagta agccgccggt ttgcgggaca ggggcttgga gcccgcgtcc ttcagtgggc 727981 ggagacgggc atacactttc cggaaaaaac gcggatccgg cttgactgtg tcgctgatag 728041 tgacgccctg cattcctttt atcggcgtat gggatatgaa ttcatgggtg ctgatgcgtc 728101 cggatatcat ttgtttgaga aagagattac ggcagaataa gcgtcctttg cagggggctt 728161 ttttgtcttt ttctaaaagg gaggcaggcg atgtgtggtc aatattattt gtgacaggga 728221 ttgtgacggc ttgtctgttt gctggcgtat ccgtattgat gcggatgaga tttcctgaca 728281 aaagtcggcc ggaatggatg ttggccgggc tgatcgtcct tggtgtgttt gcgatctggt 728341 acagcctcgt gtatgtacgc ggctgggaag gggctgcgct cggaatgctt ggattcaatg 728401 tcattttcgg agccattgcc ggatatttga tcgataaggc catccggcgt tacaggaaaa 728461 gataaggctg ctgccgtctc tcaacaggtc gaaattttca cagaccggca ggaattttct 728521 ttcgaaagga gaaatacata ttactttaaa atgaaagcgt tttccaaagc aggaaggtga 728581 tgttgatgat acacagtgtg gcaaatgggc tgaatcattt ttgtacgtgg gtgatgagac 728641 tggcctattt gaatgtgctt tggattttgt tttctcttgc aggcctggtt gtatttgggc 728701 tgatgcccgc tactgccgcg atgtttacag tggcgagaga atgggcgaag gggaatacag 728761 atgccccggt gttttctgtc ttttttcgga cgtttaaaaa ggaatggcgg gcatcacaga 728821 tcctcgggct tatcgttgtg acggctgccc tgtttctgtt tgcggatatg cggatagcgg 728881 ctcagatgga ccagcctgtg ctcgtcaatg tattcgtgag cattagtttg attttcgcgt 728941 ttgttgtgct gtatgtgttc ccggtatttt ctcattttga cgtaaaaatc agagaggtgc 729001 tgagcatcag ctttttcatt gccttcagtc gtccggcggt gacgcttttg atggcagcgg 729061 gcgctgtcgg tgtgctttgt ctcgttctgt ttcatgtcac gtttctattg tttttcagcg 729121 ggagtttact cagcctgatc ttaacgaagc tgtcctttaa agcgtttcgg tcaatggatc 729181 agcggcagga gaaagaaaag gcggcatgaa gaaaagagtt gctggctggt acaggcggat 729241 gaagattaag gataagctgt ttgtgtttct atcgttgatt atggccgtat cctttctgtt 729301 tgtatacagc ggggtccagt atgcctttca tgtgtatgat gagcagattt accgcaagtc 729361 ctcggaggtg cttcggatgt cttctgaaag gatcgaagac gagctgaaga agatagagga 729421 tgtgtcatat gaaatcatta cagacgaaca gattcagcgc atcctgagca tgcaaaatcg 729481 ggatgatacg tatgatcaat atcaaatgaa gcaggagctg tgggatcagc ttgcgggata 729541 tgccagcgat gaaaagtaca tcgattccat tcatgtgatt gatgcccgcg gctcagagta 729601 ttcagccgga agcagttctt cagatctttt gcagcaggag caggaagagg tatttaagcg 729661 agcgaaagcg aaaagtggaa gaaatctttg gatgacgctc ggcgggtcag accccgtcct 729721 gatttcagca cggcagatca ggtcctatca ccagctgagt ctgaacggct tgggcatggt 729781 actgatccag gtcaatgtaa aacagatgat tcgtgatgtg ccgaaggatt ggggcgattc 729841 agtcggagac attatgattg ctgaccaagg cggtaatttg gtgtatacgg cacatgcatc 729901 agcgcatgtt cctgaggcag caaaagagac gttgaagcac cccggttatg acttgataaa 729961 aaagaatggc aaacgttact ttatttctta tcttcaatca tcctaccaaa attggagcta 730021 ctataacgtt atcccctttg atcagatgtt cgcaaaaatt tcctttatga aaacagtgat 730081 cggcacatgc tttcttctct ttttctgtgt ggttttgctt ttcggaagga aaatcgccaa 730141 cagcatcacg gagccgattg aacagcttgt gaccgcgatg aaatcggtac agcacagcgg 730201 cattgaagca ggtgtgtcgc tttctctgcc ggaacataca caggatgagg ccggcatgct 730261 gaaccgccat tttactgtca tgatgaaacg gattaatgag ctgatggaag aaaatgtgga 730321 aaaacagctc atcattaaag aaaccgaatt gaaagcactg caagcccaga tcaatccgca 730381 ttttttatat aacacgctcg agtccatcaa ttggctggcc aaggcgaatc agcaaaagca 730441 aatctcaaaa atggtggaat cgctcggttt tcttctgcga aacagcatac atatgaagaa 730501 ggatatcgtg accattcagg aggaggcgga cattgtacgt cactatatga ccattcagcg 730561 atttcgattt gaagagcgcc tgaaattcac gttggatatt gacgatgagg tgaagcattg 730621 cctcattccg aaactgacgc tccagccgct tgcggaaaat gcgattcaat acgcgcttga 730681 accctttaca aggccatgcg ccatccggat tcaggcgaaa aaggcgaagg gctgtgtctg 730741 tattacggtc gaagataacg gccctggcat ggatggacgg attcttgaat caacgggtgg 730801 aagaggaatc ggactttgga atattcgcga gcgcatcagc ctgacattcg gagagccata 730861 cggattgcgg attcatagtg agcatgaaaa ggggacgagg attgtgatca caataccgtg 730921 ccgaaatgag gtggtgtgat gtataaaata ctgctggctg atgatgagag gattatcctt 730981 gatggaatgg cgggaatcat tgagtgggag tcgcttggcg cctcattgat cggaaaagcg 731041 cagaacggac atgaagcata tgaaaagatt gtacataagc agccgcatat cgtcatcaca 731101 gacgtcaaaa tgcccggcat ggacgggctt gagctgatca aaaaggtgtc agccgtcagc 731161 ccgtcggtgc aatttatcgt cctgtccggg tttggagagt ttgagtacgc aaaggaagcc 731221 atgaaatatg gggtgaagca ttatttgctg aaaccctgca atgaacagca gattatcagc 731281 tcgctggagg aaatcattgc tgagctgaag cggcaagatg tgcacaaaaa gaaaacagcc 731341 catctgaaac acgagctgga ccatatccgt tcctttgcag ccgatcaata cttggaaggc 731401 ttgatcgccg gtgtggccca gctttctccg ccgccttcac ttgccggaaa aaagatccgc 731461 ctcttgatct taaaagggga acaatctatt gatgctgcag ccagagaggc actcggatcg 731521 gcactgacag cggtttgcag cagcggtgaa tggaccgtgc tcgccgtaga ggagaacgcc 731581 gctgaaaagg tggcggaggt ttttgcggac cgcaagatgg ccatcagtca ggcgggagaa 731641 ctccggcacg cggggcagct gtttcgtgac acagctgaag cgtctggtga cctgcatggg 731701 agcgcagtga tttcaaaaat gatcaggctt attgccgacg agctcggaaa tccgaatctg 731761 tccttaaaat gggcggcgaa ggatatgctg tttatgaatc ctgattatct cgggaagtta 731821 tttaagcagg aaacaggcga gaaattttcc caatatgtta cacgggtgcg tcttgagcat 731881 gcgatgaagc agatgaaaat aaggagggac gtgagcgttt cagaaattgc tgaagaaatc 731941 gggtttggcg ataatccgaa gtatttcagt cttgttttta aaaaatatac cggtctgaca 732001 ccgtcagaat tcagaagaaa acagggaggc gcttccgcag gatagccatc tctgtttttt 732061 tgactttcgc cactgttttt tgagtgtttc gccctatccg aacgctttaa aataaaatgt 732121 aagcacttac attaaagggg ggattggttt gaagaagatt tgttacgtgc tgttatccct 732181 tgtctgcgtc tttttgttca gcggatgttc agcgggtgaa gaggcctcgg gaaaaaaaga 732241 agatgttaca ctcagaatcg cgtggtgggg cgggcagcca aggcatgatt atacaactaa 732301 ggtaattgaa ctatacgaga aaaagaatcc gcacgtccat attgaagcgg aatttgcgaa 732361 ctgggatgac tactggaaaa agcttgcgcc catgtctgcc gccggccagc ttcctgatgt 732421 cattcaaatg gataccgctt acttagccca atacggaaag aagaaccagc tggaagattt 732481 aacgccgtat acaaaggatg gaacgattga cgtcagttca atcgacgaga atatgctgtc 732541 gggcggaaaa atcgacaata agctttatgg atttacgcta ggtgtcaacg tgctgtctgt 732601 gattgccaat gaagatttgc tgaaaaaagc cggtgtgtct atcaatcagg aaaactggac 732661 gtgggaggat tacgagaagc tggcgtatga tcttcaggaa aaagccggtg tctacggttc 732721 caacggaatg catccgcctg atattttctt cccttattat ttgcgcacaa agggtgagcg 732781 cttttataaa gaagacggca ctggcctcgc gtatcaagat gatcagctgt ttgtcgatta 732841 ctttgaacgg cagctgaggc tagtgaaagc gaaaacgtcc ccaacacctg atgaaagcgc 732901 acagattaaa gggatggaag acgattttat cgtcaaaggc aaatcagcga ttacatggaa 732961 ctactccaat caatatttgg gctttgcccg gctgacagac tcgccgctgt ctctctatct 733021 gccgccggag caaatgcagg aaaaggcgct gacactgaag cccagtatgc tgttttccat 733081 tccgaaaagc tctgagcata aaaaagaggc agcgaaattt attaatttct tcgtgaataa 733141 tgaggaagcg aaccagctga ttaaaggcga gcgaggcgtt ccagtctccg acaaggtggc 733201 ggatgcgatt aaaccgaagc tgaatgagga agaaaccaac atcgtggagt atgtagaaac 733261 cgcgtcaaaa aacatcagca aagccgatcc gccagagcct gtgggaagcg cggaggtcat 733321 caagctgctg aaagatacgt cagatcagat tctgtatcag aaggtatcgc cggaaaaagc 733381 cgccaaaacg ttccggaaaa aggccaatga gatattagag aggaataatt gacgggaaat 733441 ggggctgacg caatgaaaaa aagccggagt ataagaaaag acaatctggc gggatatgct 733501 tttatttctc cgtttatcat cgggttccta tgctttacgg tgattccgat gggggcgtcc 733561 ctgtttctgt ccttcacgag ctatgacttg tttacggcgc cgaaatggat cgggctcgac 733621 aactttaagg aaatgtttac gggtgacgaa aagtattggc agtctctgaa ggtgacgttt 733681 acgtatgtgc ttgccggggt tccgctccgc ctcggcttcg cgctttttat cgctgtcatt 733741 ttaaacaatg cagcaaaagg aacggccatt tacagaacgc tcttttatct gccttcgatc 733801 atcggcggga gcgtcgccgt ggcgattatg tggcgcaata tttttggcaa tgacggggtc 733861 atcaatgcgc tgctgttttt tgtcgggatt gatcaaaaaa ttctttggta ccagaatccg 733921 acaagtgcgc tgtggacatt gattctgctg tccgtctggc agttcgggtc gtcaatgctg 733981 atttttttgg ccgggctgaa aaacattccg tcttcgtatt tggaagcggc aagtgtggat 734041 ggggcaaatc gggtgcagcg tttcttcaag atcacgcttc cgatccttac accgattatt 734101 ttctttaacc tagtgatgca gacgatttct gcttttatga catttacacc tgcctatatc 734161 atttcgaagg gcgagggcgg gccgcttgac gggacacttc tctattcgct ctatttgttc 734221 cagcgtgcgt ttaactattt tcaaatgggc tacgcatcgg cgatggcgtg ggtcatgctt 734281 gtcattgtcg ggctgattac gctcatattg tttaaaacat cgtcatattg ggttcattac 734341 gagtcaaagg aggaatgacg gatggagccg gtcaaccagc ctgtcagaga agccccggtt 734401 tttgagagaa aaaaagccgg gcgcgtcagt cccaaacgca tactgttcca tgtttttacg 734461 gcaacgctgg cggtgttgct gctgtacccg gttatttggc tgtttgtcag ctcgtttaaa 734521 gaaagcgcca gtatttttac aacctcacat tctctcattc cagacccttt tattctcagt 734581 aactatgctg aagggtggaa gggcattgcg ggacagccgt ttctgacgtt tattaaaaac 734641 tcggcgatta ttgtcgggct gtcaacaatc ggtgccgtca tgtcatcggc tgtcattgcg 734701 tacggatttg cgcgtatacc gtttaaggga aaaaaatttt ggtttgcgtg catgatgggg 734761 acgttaatgc tgcctcatga agtgttgatg attccgcagt atattatgtt tgcgaaatta 734821 gactggctga attcctttaa accaattgtc gttccgcaat ttttcgggca tgcgtttttt 734881 atctttctga tgatccagtt tatccggacg attcccgagg agctggatga agccgcgcga 734941 atcgacggat gcggacgctt tgcctgcttt tggcggatca ttctcccgct gattgccccc 735001 gcgcttgcga cgtctgcgat tttctccttc tattggaagt gggaggagct gattcagccg 735061 ctcttgtatt tgaataagcc ggagctttac cctgtttcac ttgcgctgaa gctttttctc 735121 gatacagagt cggcttcgaa ctggggcgcg atgtttgcca tgtcagccgt ctcgttattg 735181 cctgtgattc ttgttttctt tttgtttcag aaatatatcg ttcagggcat cagtacgacc 735241 ggattaaaat aaaaaggagt gttgcagatg gcacagctta tctttgatga agaaaaggtg 735301 acgtcggtta ttgaccggat cgtgaaacgg acatttcaga tggattttgc gtgggattgg 735361 ccgggcggcg ttgcgtttta cggtgtggcg gaggcctatg aagcgacgga aaacgaggaa 735421 tatatcaatc tgttaaaaac gtgggtggat gaacagctgg aggatgggct gccgccgctt 735481 tcgatcaacg gagtttccat tgggcatacg cttttgttcc tccacaaggt gacaggtgat 735541 gacgtgtatt tggaaacagc ggccgagatg gcggaatatg tgctgcataa ggcgccgcgc 735601 tttggcgagg gtatccttca gcatacggtg aatgcggcag aatacgtatt ccctgaacag 735661 gcatgggcgg atacgctgat gatggctggg ctgtttatgc tgagaatcgg gcgggtcatg 735721 gagcgtgagg attattttga agacggcctg cgccagtttc acggacatga ggatgtgctt 735781 caggaccctg tcacgaattt gtactaccac gcctgggaca acaaagcgca aaatcatctg 735841 tcggggattt attggggcag ggcgaacggc tgggcggcac tcacgatggc aaaggcgctc 735901 ccgcttattg aggtgacaca tccttccttt atgatcatcg acggatcgct cagagaccag 735961 ctgagcgcgc ttgtccggct tcaggatgaa tcagggctgt ggcatacaat tttggatgat 736021 ccggattctt atctggaggt ttcggcatca gcgggtattg cttctgctct gatgtcgagc 736081 ggaaagctgt atacaaaata tgtgcagaaa tcgcttgccg ccattttgga tgcagtggaa 736141 gaggacggac gggtcagcag ggtatcggcc gggacagccg tcatgaaaaa tgccgaagga 736201 tacaaacagg tgccttacaa acgaatacaa ggatgggggc agggacttgc gctgacgttt 736261 cttgctgatg ttttgaaaac gaaaaaacgc ttgtatcagt aaagatagcg gcggggggag 736321 agggatgaaa aaacagcctc aacagaagga acgggtttct cgctggaagg gaacgtattt 736381 caaaagaaac tttgtcttca ttttgctgat tgcctgtatt cccggattgc tgactggcgg 736441 cgcaatctac tttctttcga tcgacaaggt ggagaaagag ctgcagagat cgcatgaaac 736501 acaggtggcg cgtgaggtca gccgaatgga tgagaagctg ggagtgcttg aactggcact 736561 cacccagatg gcctacgatt cttcactgat gaacggattg gccgagaggg atttggagaa 736621 agactttacg ttctcctatc aattaacgaa aaagctgttt cttttgcggg atcagcagcc 736681 gctgatcgag caggcttcca tctttctgaa cagcccccgg ccacttgtgc tgagccctga 736741 atacagcgct ttgacagaac aggaggcgct tcgcaagtat cgctcgctgc ttgcctcaga 736801 ccacagcatt tattggaaac ggtcgggaaa ccaagcgatg ctgatccagc tcattccggg 736861 cgcggcggag aaaccgttcg gcgcgatcat gctggcggtt gatccgaaag aaatggaatc 736921 aatcctgcaa agcttgtccc cctatcctga tggcagtgcg ttgcttttag atcaaaatcg 736981 agaggtgctg tttcatgagg gggaaaaaga ttttgaaaag actttacttc atgagataaa 737041 aaaacagcct gctgagaacg gccattttca gatggaatgg aaaggcaagg tgtattctgt 737101 ctcctttgga gaaatgaacc ggatgcatca gcaatggacc tttgtgtcag cggcgcctct 737161 ttcagctatt acagcgccga tggtgttttt atcaaaagtg atcatcgtga tgctggtcat 737221 ttgcatcggt ttggcggtgt gcatgacatg gtatgcatca aaaaaaatct atcgtcccat 737281 ccagcatttg cttggcttgt ttaccggagg agagaagaaa acatggcagg cgtccgggca 737341 ggatgaattc aaatggattg aaaagagatg gcaggatcta tcccttgaaa gccggaagct 737401 ccaacagcag ctcctgcggc agacgcccca tatgaaaaag agttttttgc agcatctctt 737461 acagagcgat ttttactatg acaacgagga aagcctcaga tttcggatgg aggaggctgg 737521 ctggaacatc ggcggaaacg tgtttcatgt gcttgatcta caggtgacag ggctccgctg 737581 tgaaaaaagc atcttccgtg aaggtgatga acagcttgcc gtgtttacac tgactaatat 737641 cgctgaggaa ttggcggcta aacgcgtttt tcagctctcc atacttgata tcggccggct 737701 ttctgtcacc gttcttgtga tgaaaacaaa cagctctgat ctgaaggcgt atataacgga 737761 gctggcacgc caatttggag atgtaaccgg actatgcctg acctcgacat tgagcagcaa 737821 gacggagcgt gtcacggaaa ttccttcttt atttcaggat gtgaaatgcg gcaaatcccg 737881 caggaagttt gctaaccggg atcaggtcat tgatttgcag gccgacttcc ctcgggatga 737941 gcagttcgct ccttattacc cttttgagct ggaaaaacaa attgttcaga ccatccggct 738001 ggaaagaaaa caggaagcca aggaactgat agatggatgt atgaaggaac tgtcggaaaa 738061 agcggccata gacaggcatg tgcattccgc cctgattcag ctgttttccc gcattcagga 738121 ggatattttg cattccgggc tcaatcccag cgaactgttt cagcaccgga atccgtttct 738181 tgatatttca gaattgcgcg aacctaacga agcggcggcc tggctgatgg atgtagtggt 738241 gacgccttac ctttccaagc ttgagggcag aaaaaacaga cagcaaaagc agctggcaga 738301 acgtgtgatt gcgatgattc acgaacagta tatggcggac atttcattgg aaagctgtgc 738361 cgatgcgctt ggcatgaatt cctatacgtt aagcaaggca tttaagcaag tgaccggcat 738421 taattttatc gattatgtga cccagatcag aatcgaaaag gcgaaagaac tgctggtcaa 738481 tacgaataaa aaaattcatg atgtgtctga agaagtcggc tatcgccaca attatttcaa 738541 tcggattttt aaaaaacagg tcggcatgcc gccgggtgtc ttcaggcaaa tgtatcagga 738601 aacgccgtga aaggagagaa catgtgatga agaaaccgat tcaagtattt ttagcggggg 738661 attccactgt gagtgactgc ccgcctcatg aagcgccgat ggcggggtgg gggcaggtat 738721 tcgggcaatt gttttctgaa ggtgtgctgg tccgcaatca tgccaaagga ggagcgagca 738781 ccaattcttt tgtggaggaa ggaaggcttc aagcaattgc cgagcacatc acacaaggcg 738841 attatttgtt gattcaattc ggccacaatg accaaaaacc gcgggggacg aagccgtact 738901 ccacatttca gcagtttctt accttgtttg cagatacggc acgcgaaaag ggcgcgcatc 738961 ctgtgttcgt cacatcggtg cagcgccgcc gctttgatga aaacggacgg atcgagcata 739021 cgctcggtga gtatcccgat gcgatgaaag cactggcgaa ggagctcgat gtacctgtga 739081 ttgatctgct tgcgaaaaca aaggtgctgt atgaagcata cgggccggag gagtcgaagc 739141 gattgttcgt ttggtttcag ccgaatgaac atccgaatta cccggacggc attgaggaca 739201 atacgcattt ttcggaaaaa ggtgcaatgg aggttgcgaa gcttgtggca gaaggcattg 739261 aagagctcgg acttccgctt aaggaccacc ttgtgagccg ggagggaaaa gaacatgtat 739321 aaggaaggcg cttgcttgta ccgcaatccg ctccggtcta aaagcgatgt gaaggattgg 739381 cggatggagg gaggcggaca gatctcattt gacgatcaca gcttgcacct gtcacatgtc 739441 caggatgaag cgcactttgt cttttggtgt ccggaaacct ttccagacgg catcattgtg 739501 acatgggact tctctccgat cgagcagcct ggactgtgta tgctgttttt tgccgctgcg 739561 ggtattcgcg gcgaggattt gtttgaccca agtctcagga aaagaacagg aacataccct 739621 gagtatcatt caggagatat caatgccctc cacctgtcgt atttccgcag aaaatacgcg 739681 gaggaaagag cgttccgcac ctgcaattta agaaaaagcc gcggtttcca tctcgccgca 739741 atgggggccg atccgctgcc ttctccagac gacgctgatt ctccgtatcg tatgaagctg 739801 atcaaagaca aaggctatgt gcacttttca atcaatggtc tgcccattct tgagtggatg 739861 gacgacggca gcacatatgg gcctgtgtta acaaaaggaa aaatcgggtt ccggcagatg 739921 gcccccatga aagccgttta cagggatttt gccgtgcatc aagcggtgag aagatgaaga 739981 cgactgtaac ggatgcgctt tatgcaggct gcgaagcggt ggtgaaaata gcatggctca 740041 acgggctgtg gctgttgttt acacttttgg gcggcgttct tttcggatgg gcgccgagca 740101 cagctgcgat gtgtgccgtt ataaggaaat ggctgatggg gcaaaaggat gtcccgatat 740161 tttcgttatt tctcgatacc tataaaaaag agtttctcaa ggttaatgcg atcggattgg 740221 cgttttcggc tcttttgctc atattgtctg ccaactatca ttatttttct gccagtacga 740281 attggctgtc ctttgccgta acaagctgca cgctgcttgc agggcttttg tatatcatcg 740341 cgctgatgta tgtgtttccc ctttatgtgc attaccagct cccgcttcgc aaatatattc 740401 cgcaggcact gctgtttggc gccatgagac cgctgacaac tggctgtatg ctgatcgggt 740461 gcggatttgt cctttatttg ctgtatacgc ttcctggcct gatcccattt tacggcccgt 740521 gtttatttgg gcttgtgttg atgttttttg ctcttagggg atttcaaaag acggaggccc 740581 agcaccatca agccgggtaa caaaaaaatg acaaataagc aaaaaagtgc agtgtccgaa 740641 ataggcagat gcaaaaaagt gaaattgaag acagctcaca aagcgcataa aatccaattt 740701 aagtaagcgc ttacagataa atgagaagga gctgtctgat gattagacga aggaaacgca 740761 tgtttaccgc tgttacgttg ctggtcttgt tggtgatggg aacctctgta tgtcctgtga 740821 aagctgaagg ggcagcgcgg cagatggaag cgctgaaccg ggggcttgta gcggtcaaga 740881 cggacggggg catttttgtc agctggcggt ttcttggaac cgaaaacgca tctgttttgt 740941 tcaatgtgta cagagacggg caaaaactga atgctgcgcc tgtcaaaaca acgaactatg 741001 tggataaaaa cggttcggcg ggctcaacgt atacggttcg ggctgttgta aacggtaccg 741061 aacagccggc ttctgaaaaa gcctccgtat gggcgcagcc gtatcattcc gtcccgctgg 741121 ataaaccggc tggcggcacg acgccaaagg gtgaatctta cacgtacagc gctaatgacg 741181 caagtgttgg cgatgtggat ggtgacgggc aatacgagct gatcctgaaa tgggacccgt 741241 ccaactcaaa agacaattca caggatggct atacgggtga cgtgctgatt gacgcgtata 741301 aactggacgg cacaaagtta tggcggatca atctcggcaa aaacatcaga gcgggcgcgc 741361 actacaccca gtttatggtg tatgaccttg atggtgacgg aaaagcagaa gtggcaatga 741421 aaacggcaga cgggacaaaa gacggcacgg gcaaagtaat tggaaatgcc aatgcagatt 741481 acagaaatga acaggggcgt gtgctttcag gccctgaata tctcactgtg tttcaaggtt 741541 caaccgggaa agagcttgtc accgcaaatt ttgaaccggc gcgcggcaat gtgtcggatt 741601 ggggagacag ctacggcaac cgtgttgacc gttttctcgc cggcattgcc taccttgatg 741661 gacagcggcc gagcctgatc atgaccagag ggtattacgc taaaaccatg ctagttgcct 741721 ataacttcag ggacggaaag ctgtcaaagc tttggacgct ggactcctca aagtcaggaa 741781 atgaagcgtt tgccggacag gggaatcaca acctgagcat cgcggacgtt gacggggatg 741841 gaaaagatga gattattttc ggctcaatgg ctgttgatca tgacgggaaa ggcatgtact 741901 cgaccggctt aggccatggg gatgccctcc atacaggaga tcttgatccg ggccggccgg 741961 ggcttgaggt gtttcaagtt catgaggaca aaaatgcaaa atacggctta tctttccggg 742021 atgctgcaac tggaaaaatc ctttggggcg tttatgccgg caaggatgta ggccggggaa 742081 tggctgctga tattgacccg cgttatccgg gacaggaggt gtgggcaaac ggttctctct 742141 actcagcgaa aggggtcaaa atcggaagcg gggttccgtc ctcgaccaac ttcggcatct 742201 ggtgggacgg cgatctgctc cgggaacagc tggacagcaa ccgaattgat aagtgggatt 742261 atcaaaacgg cgtatcgaaa aatatgctga ctgcatcagg cgcagcggct aacaacggca 742321 caaaagcaac accaacgctt caggctgatc tgctcggtga ctggcgcgag gaagtggtgt 742381 ggagaacgga ggacagcagt gctctgcgca tttacacgac gaccattccg actgagcaca 742441 ggctgtatac gctgatgcac gatccggtgt accggcttgg catcgcctgg caaaatatcg 742501 cctataacca gccgccgcac acaagcttct ttttaggaga cggcatggcg gaacagccaa 742561 aaccaaatat gtatacgcct taactgaaag ggggaaggaa cgggctgcgc gcagcccgtt 742621 cccatcaaat gaaaccaaaa aagaggcaaa tggaatacct gaccagaggt ttgattgcgg 742681 tacagacaga acagggcgtg tttgtcagct ggcgttttct cggcacggat catgagacga 742741 cggcttttca cctttatcgg gatggaaagc ggatcacccg cgatccaatc gctgaaagca 742801 ctaattttct cgatcaaaac ggaacggctg actctgttta tcaagtggcg gctgtcaata 742861 aaggacggga agaaaagctt tccaagaaag ctcgtgtttg gcaggaaaat gtcctggagg 742921 ttcctcttgc caaaccggaa ggcggtgtga cgccggacgg aaagccgtac acttacagcg 742981 ccaatgatgc cagtgtcggg gatatagacg gggatggaga atatgaaatg atcctgaagt 743041 gggacccgtc caattcaaaa gacaacgctc atgacggtta taccggggag gtgctcatag 743101 atgcctataa actggacggc acctttttgt ggcgcatcaa cctcggcaga aacatcagag 743161 cgggtgctca ttacacgcaa tttatggtgt atgaccttga cggtgacgga aaagcagaaa 743221 tcgccatgaa aacagctgac ggcacaacag acgggaaagg acatatcatc ggtgatgagc 743281 aggccgattt tagaaacgaa cagggcagaa ttttgtccgg tccggaatat ttgaccgtgt 743341 ttaaaggaga aaccggtgag gcgctcacga ccgtggaata tgaaccgccc cgcggcaagc 743401 tggaggattg gggagacggc tatggaaacc ggatggaccg ttttctcgcc gggaccgctt 743461 atttggatgg ggagcggccg agccttgtta tggcgcgcgg ctactatacg agaaccgtgc 743521 tcgtggcata cgatttcaga aacggaaggc tcaaaaaacg atgggtattt gactccaacc 743581 agccgggaca tgaagcatac gcaggacagg ggaaccacag cttgagcgtg gcggacgtcg 743641 acggagacgg aaaggatgaa atcatatacg gcgcaatggc tgtcgatcat gacggaaccg 743701 gcctgtactc aacgggcctc gggcacggag acgcgatgca tgtaggggat ctggacccgt 743761 cacgaaaagg gcttgaagtg ttccaggtgc atgaggacgc cacgaagccg tacggactgt 743821 cgctgcgaga tgccggaacc ggtgagatat tatggggcgt ccatgctgga actgacgttg 743881 gccggggcat ggcggctcat attgatccaa gctacaaagg atcgctcgtc tggggaattg 743941 atccgccggg caatgatggc atgtcgtacg ggcttttcac gagcaaaggc gaaaaaatca 744001 gcgacaaagc gccctcttca gccaatttcg ccatctggtg ggacggtgat ttggtcagag 744061 aactgcttga tcatgactgg gacggaacga tcggcaggcc aaagattgaa aaatgggatg 744121 ctgaaaacgg ctgtctgaag acgatatttc agccggccgg cgtgttgtcc aacaacggca 744181 cgaaaggaaa cccggttctt caggccaacc tgttcggaga ctggcgggaa gaagtgatat 744241 ggagaacgga agacagcagc gcgctccgta tctatacaac aacacatctc acccgccact 744301 gcttttacac gctgatgcat gatccggttt acaggctcgg catcgcctgg cagaataccg 744361 cctacaacca gccgccgcac acgagctttt acctcggaac gggaatgaaa aaaccgccga 744421 agcccgccct gtacatagcg ggaagcaaag cggaggcgcc gctgtaggag gactaaggga 744481 taagacgcaa aggctgaacg ctacgccaag atgattagag aactggcagg acgaaccaat 744541 gctcaagcgc tgtacgcacc ggttttttca agggaagagc tatccgtgat ggaagctgta 744601 taaaaaacga ggaggaatga aaaaatggca aatcatattt atcttgccgg cgattcgact 744661 gttcaaacgt atggagacag cacaaatcaa gggggctggg ggcagtttct cggctcgcat 744721 ctgccggagc atattcaagt gatcaacaga gcgatcgggg gaagaagctc gaaaacattt 744781 gtggaagagg gcaggcttca ggcaatcctc gatgtgattg agccggatga ttggctgttc 744841 gtgcagatgg gccataatga cgcgtcaaaa aataagccgg agcgctacac cgagccctat 744901 actacttata aacaatattt aaagcagtat atcgcaggcg cgcgggaaaa aggcgcccat 744961 ccgcttctca ttacccccgt agcccgcttt cattacgaaa acggcgtgtt tttgaacgat 745021 tttcctgatt actgcattgc catgaagcag acggccgctg aggagaatgt ccagctcatt 745081 gatctgatgg agaaaagtct cgctttcttt actgagaagg gcgaggaaaa agtgtacacc 745141 tattttatga tttcagaagg gattaacgat tacacgcatt ttacaaaaaa aggcgcaaat 745201 gaaatggcga aacttgtggc aaaaggcata aaggagctcg gcctgccatt gacagaatcg 745261 atcatcaaag aaaggtgaaa atgtgatgag aaaactgtat catggcgctt gctattatcc 745321 ggaattatgg gatgaagaga cgattcagca ggacattgac atcatgcgtg aagttggcgt 745381 aaatgttgtg cggatcggcg aatttgcctg gtcagtcatg gaacctgaag aaggaaaaat 745441 tgacgtcggt tttttcaaag aaatcatcgc ccggctgtat gatagcggga tcgaaacgat 745501 tatgtgcacg ccgacgccta ccccgccgat ttggttctca catggccggc ccgaacgcat 745561 gcatgccaat gaaaaaagag agatcatggg gcatggctcc cgtcagcatg cctgtacgaa 745621 caacccgtat ttccgaaaaa aagccgccat catcaccaca gccatcgcca aggagcttgg 745681 ccggctcccg gggctgatcg gatggcagct agacaatgag tttaaatgcc atgttgcaga 745741 atgcatgtgt gagacatgct tgcgcctatg gcatgactgg ctcaaaaatc gctacggggt 745801 aattgagcgc ttgaatgaag cttggggaac cgatgtgtgg agcgagacct atcagacgtt 745861 tgagcaagtc ccgcagccgg gaccggcccc gtttctgcat catgcctctc tacgcactat 745921 gtatcagctg ttttcgatgg agatgatcgc ttcgtttgcg gatgaacagg ccaaaatcat 745981 ccgctgctat tcagatgcgc cgatcacgca taacggatca gtcatgttca gcgtggacaa 746041 tgagcgaatg tttcagaatc tcgattttgc ctcctatgac acgtacgctt cgcaggaaaa 746101 cgcctctgcc tttttattga actgtgattt atggagaaat ctgaaacaag ggcgcccgtt 746161 ttggattttg gaaacgagtc cgtcgtatgc cgcctcgctt gaaagctccg cttacccgca 746221 cgcagacggg tatttgcagg ccgaagccgt atcgtcctac gccttaggga gccaggggtt 746281 ttgctactgg ctatggcgac agcagcgttc aggcagcgag atttcccacg gttcggttct 746341 cagtgcctgg ggcgaaccca ccatcggcta tcaaaatgtg ctggcggttg agcgggcaag 746401 aaaggaaatc gagcctatta ttctatcgac tgaacccgtt caagccgagg cggcgatgac 746461 ttactctgac agagcaaaag catttattaa aactgagcct caccggggac tccggcatcg 746521 ttcgcttgtg acgcattttt atgaacgtat tctcaacacg gggattcacc gtgaccttat 746581 tccggaaggc gctccactgg acggctatcg cttgctgttt acgccatttg tgccgtattt 746641 gtcttctgaa tttatcaaaa aagcttcggc attcgctgaa gcgggcggca tctggatcac 746701 cgggccgctg acaggaggac gcacatgcga gcataccatt cataccgatt gcggacttgg 746761 cgaacttgag aaaacgtcag ggatcaaaac actttttacc tttccgatga atgagaacgt 746821 gaatacagga aaagcgtttg gcatcacggc gccgctcgga ctgtggagcg cggtgtttga 746881 cacagagagc ggaaacaccc ttggcacggt tgaagcagga ccgggggcgg gccatgcttt 746941 tctgacggaa cggaattacg gcgaggggaa aattgtcatg ctgggctcgc ttccatccgg 747001 gaaagaaggg gatgcgatgc tggaagcgct cgtcaggcat tatgcggagg aagctgttat 747061 ttccagccgg tcggatgtga cacccggcac gatcgttgcc ccgcgtatag gcgaaaacgg 747121 ccttgtgtgg atcgttgtga atatggatgg aaaaggcggg agcgtgacat tgccggaatc 747181 gggaacggat ttgttgacgc accgcttgga aaaggcgggg agactggcgg tcggaccgca 747241 tgaataccgt gtgattcaat ttgacaatca cagctgattc tttgtatcga atcagctttt 747301 ttctatggag ggagagacag atgaaaaaga tcaaatggtt atcaggacag ccaaaggtga 747361 caagcggcgt gacgtggggc atgccatgga aaaaaggaga attaaaaaaa ggagaccgtc 747421 tggcgcttat gaatgaaaac gcggaaacgc gatatgtgca aagcgaaccg tcggcctatt 747481 ggccggacgg gagcatcaag tggacgaagc acgcggcggt gtttggcggt caggaaaacc 747541 aaagctttac agtgcacaaa agagaagtgc cgcagccaac tgaatcgctc agcattcttg 747601 agacagagca tgatatccaa gtggatacag gagcactcgt ttgtaccatt cataaaacag 747661 gatctgattt cattcaatca ttgcagatca atggaaagcc gatcgccgca ggcgggaggc 747721 tcgttgcgat aagagaaacg agaaaagagt cagcggcgaa aatggttctt ttgcatgaaa 747781 ggtctgtcag ctttatcaaa cgggcggcga ttgagcagag tggtcctgtc aaagcagtag 747841 tcaaaatcga gggagtgcat gtgcttcata aaacgtatga ggaatggctg ccgtttgtca 747901 tccgattaac gttttatgcc gggctgtctg agatcggcct tgtgcacacg cagctgattg 747961 acaggagcgg taaactagaa ttcgttaagg ggctcggcat cgaattcgac ctttttttgg 748021 agggagagcc gtacaaccgc catttccgct ttgcgggaga gaaagggatg tataaagaac 748081 ccgcccagct gtttggcaca cgtaaattca atgaacgata tccgctttat gaaaaacaaa 748141 tcaatggcga aatgctgtct ccagatgaag agcataagga atggtttgca catggcacac 748201 agaatgcggt ttgggacgat gtcaagatcg tgcaagattc cagcgatcat tacagcctgt 748261 caaaacggac cggaaaagat tatgcgtggg ttggaatgct gcatggcagc cgggcgaagg 748321 ggctctgcta tgcgggcgga aaaaatggcg gtgtggctct cggcctgcgg tatttctttg 748381 agaaatatcc ttcagcactg gaaatcacag gtcttgccgg cagccgcccc aaaatgacta 748441 tctggctttg gcctccggac ggcgaagcga tggatttgcg gcattataca ggaaacactc 748501 acgtggccag cgcgtatgaa ggctttgatg aaatgcgctc tgatccgaca ggcattgcga 748561 acacaaatga aataagcctg gcgtgctttt cgcacatgcc gtctgacgaa gtcctcaatg 748621 cgctggctga caaatggcag gcgcccccgc tcattgtatg cgagccggac gtctattacg 748681 aatcaaaagc actcggggta tggagcatca ttgacacatc ccatccgctc aaaaaagagc 748741 tggaagaaca gcttgatgcg gcctttctgt tttataaaaa ggaagtagag caacgcagat 748801 ggtacggttt ttggcattat ggcgatgtca tgcatacgta tgacccgatc cggcatatgt 748861 ggcggtacga tctcggcgga tacgcatggc aaaacaatga gctcgttccg accctatggc 748921 tgtggcaggc gtttttccgc tcaggcagag aggatatctt ccgaatggca gaagccatga 748981 cccgccatac gagtgaaacg gacagctttc acctcggtga atatgccggg cttggctcac 749041 ggcataatgt tgtgcactgg ggatgcggct gcaaggaagc gagaatcagc atggccgggc 749101 ttcataaatt ctattattat ctgacgggtg atgaccggac gggagatctt ttgacagaag 749161 tgaaggatgc cgattatgcc cttgtcaaaa ccgatccgat gcgcgctttt tacgagaaag 749221 gcaagcaccc gactcacgcc agaacgggac cggactgggc ggcgttttgc tcgaactggc 749281 tggcggaatg ggagcggacc gaaaattcgg aatatctcaa aaaaatcgaa acgggaatca 749341 actgtctgaa gcggctgccg ctccgcttat tatctggccc gacatttgaa tatgatccgg 749401 cgacctcgat gcttcatcat atgggagacg gcattgcggg cggatatcat atgatcattg 749461 ccttcggcgc gccgcaagtg tggatggagc tggctgagct tcttgatgac tgggaatggg 749521 aggatatgct gagtgaattc ggcgaatttt acacactcag tgatgaggaa aaacgaaaaa 749581 aaagcggagg cgctcttcat gacgggcatt ttcactggcc gatgttcgcc gccggtatga 749641 cagcctacgc cgcaagaaaa aagcaagatc ctcatctcgc cgccaaagcg tggaatcttt 749701 tgctagaaga taagctcagc catacgccgc ttccgatcaa accggagcgc atcgagacat 749761 ggacgcagct agaggagctt ccatgggtga caacgaacac tgtctctcaa tggtgtttaa 749821 atgtcatagc ggcgctggaa ctgatcggag attcccttcc ggcaaaaaaa gaaacatcgg 749881 gcaaaaaagg ataacagccg gaatttcata ggagaaatgg tgcaaaaaat gaagattgca 749941 agaatttatg taagcgcttt atattgagag gggcaaaggg gaaatgcaaa ttgaaaaaag 750001 ggggacttac gcaacatgaa aataagaatg cgaaaaaaat ggatggcctt gccgcttgct 750061 gccatgatga tcgccggatg cagccattcg gaaacatcca attcagcaag cggttcgaaa 750121 gatacgatca aaattatggc gccgctctta tcgccggaaa gcccaagtga taagagccct 750181 tcattaaaag cgctcgaaaa atacacaggc aaagagatta aggtcacatg ggtgcctgat 750241 tcatcctaca acgacaaatt caacatcgtc atggcttcag gagagatgcc tcacgcgatt 750301 gtcattaaag ataagtcagc cggctttatc aaatctgtca aagcaggggc gttttgggag 750361 ctgtctcctt atttaaaaga ctacaagaat ttaagccagg cagatgaaaa gattttgaag 750421 aacagctcgg tgaacggcga ggtgtacgga atctacagaa cgagggatct gatcagggcg 750481 tgtatgatca tcagaaccga ctggctgaaa aatgtcggtc tggatatgcc ggaaacgctt 750541 gatgatttct atgaagtgct gaaagccttt aaggaaaaag atcctgacgg aaacggcaag 750601 gatgatacgt acggcatggt cgtgccgaaa tggatgggac tcggcaacgg aagcccatgg 750661 gatgttctgc aaatctggtt cggcgctccg aaccgctacg gtgttgaaaa cggaaagctg 750721 attccagatt ttacaacgaa ggaatacatg gatgcgctca cgttttttaa aaagctctat 750781 gatgagggct tgatcaataa ggactttgct gtcatggatt ctgcgaagtg gaatgatccg 750841 gttgtaaaag gaaaagcggg tgtcatcgtt gatacaggct caagagcgtc tcaaatccaa 750901 agcgcgatgg aggaggcgga tgagtcgaac aaggatatca ttgatatcgt cggctcgctt 750961 gagggaccga atggcaagcg caccttcccg acatctggtt attcaggcat gatcacgata 751021 ccaaaatcaa gcgtcaaaac cgaaaaagag ctgaaagagg tgctgtcctt cctcgataag 751081 atgaatgata aggaagcgca gattctcacg aacaacggag tgaagggccg caattacgag 751141 ctcaaggacg gcgtattcac ctcacttgaa aaaaacaata aatctctcct gtatgagcat 751201 gaaggcttgg cacagttcag catgtcgatt ccgaaaagcg agtattacat cgaagaccag 751261 aaaaccaagc tcttccagca tcgcaaggac atcataaccg aaggagaaaa aatagccgtc 751321 tttaaccctg ctgagtcgct tgtatctgat gtctataccc aaaaaggagc ccagcttgac 751381 aacatcatcc tcgacgcgag aacacaattt atcattggag aaattgatga aaaagggttc 751441 gatgatgcgg tggagctttg gaaaaaaagc ggcggcaatg aactgatgaa ggacttgaac 751501 aaattgtacc aatcgtcaaa ataaaccgat gcgcctgcct ttcggcgggc gccccggtat 751561 cacgaaagga gaacagatat ggaaacagtg ccgaagaaga gagatgcacc tgttctcacc 751621 gctggaaaag gcatcagctg gatggctgcg ctcaaacggg acaaatggct ttatcttctt 751681 cttattcccg gtctgcttta tttcttgatt ttcaaatact tgccgatgtg gggtgtgctg 751741 atcgctttta aagactattc gccatatctc ggcttctgga aaagcgaatg ggtcggcttt 751801 gattatttca aagacttttt tatgaatccg gattttttcc ggctgctgcg caacaccctc 751861 atgctggcga gtctggatct tttgtttgcc tttcccgcgc ctctcatttt ggctctgctt 751921 ttgaatgagg taagaaaggc cgtgtataaa agatgtatcc aaacctttat ttacgtaccc 751981 cattttgtat catggacaat tgtggtcagc atcaccttcg ttttctttac tgtcgataca 752041 ggtgtgatca acaaattgat tatgagcctg acaggtgagc agatttcttt cttgtcggat 752101 gcagactggt tccggccaat gattgtgatg caaagcattt ggaaggagac aggctgggga 752161 acgattctat ttttggcagc gcttgctacg gttgatcaag agcagtatga agcggccatc 752221 atggacggag cggggcggtt caggagaatg tggcatatta cgctgccggc gattagaagc 752281 accattatcg ttttgttgat tttaagaatc ggcagctttt tgaatcttgg ctttgaacag 752341 gtgtatttga tgacgaactc actcaaccgc agtgtggctg acatcttcga cacgtatgtg 752401 tacatgatgg ggattaccca aggggcgtat agctacagca cggcggtcgg tttgtttaaa 752461 tcagttgtcg ggattatctt gatttttggc gccaattaca ttgcgaaaaa gtttgatcag 752521 gaaggattgt tttagaggag ggagaggtat ggctgaaatt cacacgatgc acaacaccaa 752581 agccggacgg gtgtttgacg tctgcaacat tctgtttctc ggcggtgtcg gcgcgattac 752641 cattttgccg tttttatata ttatcgccgg ttcctttgcg acagaagcgg aactcgccca 752701 gcggagcttc tttattttcc cgaaaacctt tacacttgat gcttacaagt atgtgttttc 752761 gacaccgacg ttccttcgaa gcatgggcgt gtccatcttc atcacggtgg ttgggacggc 752821 tgtacagctg ttttttacct tcacgatggc gtatccgctg gcgaaacggc atgtgaaggg 752881 acggaatctg ctgttgaatc tggtgatttt ctccatgctg ttttcaggcg gcatgattcc 752941 gacgtacctt gtcgtaaaat cacttggcct tttggatacg tattgggcat tgattctgcc 753001 gatggcgatt aatccgttca accttattat tatcaaaaac ttctttcagc agctgccgcg 753061 cgagctggag gaatcagcaa aaattgacgg ctgttccgaa atcggcgtct tctggcggat 753121 cgccctgcct ctgtcaaagc cagttattgc gacctttgcg ctgttttatg cggtcgggat 753181 ttggaatgat ttcttccacg ctctcttata tatcaatgac agtgcaaaat ggccgctgca 753241 aatggtgctt cgccaagtca caattttatc ggatttaacg gcgaccaatg gtgatacgat 753301 gcaaaatgca gttccgccgg agcagggaat taaactcgct gtcattgtca ttgcgacgct 753361 gccgattttg gcggtctatc catttttaca aaaacacttt gcaaaaggaa tgctgatcgg 753421 ttcggtgaaa ggctgagaaa gggagtgttt catatcagta cattagatca gattaagatt 753481 gcctatatcg gcggggggtc ccaaggctgg gccagaagcc tgatgagtga tttgtcgatt 753541 gatgaacgga tgtcaggcac ggtggcgctc tatgatcttg attttgaagc cgctcagaaa 753601 aatgaagtga tcggcaatca cagcgggaac ggcagatgga gatatgaggc tgtttctact 753661 ttgaaaaagg cgttatcagc cgcggatatc gtcattattt ccattttgcc gggatcactg 753721 gatgatatgg aagtcgatgt gcacttgcct gagcgctgcg gtatttatca gtctgtaggt 753781 gatactgtcg ggcctggagg gatcatcagg ggcttgcgtg ctgtgccgat atttgcggaa 753841 attgcccggg caataagaga ctacgcacct gaatcatggg tcattaatta tacaaacccg 753901 atgtctgtct gtacaagagt gctgtataaa gtgtttcccg gcatcaaagc gattggctgc 753961 tgccacgagg tattcgggac gcaaaagcta ttggcggaaa tggtcacgga aaggctgggg 754021 attgaggtgc cgcggcgtga ggatatccgc gttaatgtgc tcggcattaa ccattttaca 754081 tggatcacaa aagcctctta ccgccatatt gacctgttgc ctatattccg tgaattcagc 754141 gcgcactatg gggaatcagg atatgagctg gagggggaat gctggaggga cagcgtcttt 754201 tgttcggcac accgtgttgc gtttgattta tttgaaacgt atggcgccat ccctgctgcg 754261 ggtgacaggc atctggcaga gtttcttccc ggcccatacc tcaaacagcc tgaagtatgg 754321 aaatttcatc tcacacctat atcattcaga aaacaagaca gagctgagaa acgacaagaa 754381 acagaacggt tgatcgtgca acaacggggc gttgctgaga aagcttcggg agaagaaggc 754441 gtgaacatca tagcggctct tctcggattg ggtgaactcg tcacaaatgt aaatatgccg 754501 aatcaaggcc aggtcttaaa ccttcctata caagccattg tcgaaacaaa cgcattcatc 754561 acaaggaacc gtgtccagcc gattttgtcc ggagcgcttc cgaaaggtgt ggaaatgctg 754621 gcggctaggc atatatccaa tcaggaggca gtggcggacg caggtttaac aaaggatact 754681 ggcctcgcgt ttcaagcctt cctcaatgac ccgcttgtcc agattgaccg cagtgatgca 754741 gagcagcttt tcaatgacat gctccaatgc atcatgcaaa gctgagcttg ccgattagct 754801 ctttccggtt tagaaaggaa agcattgacc atactgatag tataatcaag aagtaggtgc 754861 tatcaatatg ggaaattatt taagtgttgc ggtagaactg gtctgcggtt taggcatttt 754921 atttatcatc ttaaagcttc tcgggaaaac ccaattttct caaattacgc cgtttgactt 754981 tatttctgct ttaattttag gtgaattggt cggaaatgcc gtctacgatc atgaaatcaa 755041 aatcaaagaa attatttttg cttcgctatt gtggggcgtg ctgatttata ttattgaatt 755101 tatcacgcaa aaaatgaaat catcgcgaaa gttcttggag ggcgagccga atatcgtcat 755161 ccgcaaaggg gagcttcaat ataaagtaat gaagaaaaat aagatagaca ttaaccagct 755221 gcaaagccta ttgaggcaag ctgggagctt ttcgatccaa gaagtagaat atgcgattct 755281 tgaaacaaac gggatggtca gcgtgcttcc aaaatcagac tttgacaaac cgacaaataa 755341 ggatttgcag attccttcga agtccgtttc tctgccgatc acgttaatca tagatggaga 755401 gattgtgcgg gataatttga aggaagcagg tgtggatgaa cagtggctga aacaagaatt 755461 gaaaaagaag aacattgata agacagagga cgtgttattt gcagaatggc ataaaaataa 755521 gccgctgtat actgtaacgt acgaacaaag cagatcaaca tgactcttag aaaaaagctt 755581 gcagcaaggc gcaagctttt tattgattgt atgtcccttg tttgacagca cgtacatggt 755641 acatgctcac ttcagtgctg atcagatagt caggctttgg tttgcctttg tttgctttat 755701 ggccggcgat atgcgcatcg cttttttccc attgcttcca gtgatcctct gattcccagc 755761 gaatcatgac aacaacttct tcatcaccgc ggcgcacatt tttctcaagc actgtcacat 755821 caattaaacc ttcttgtttt tcaatgattc cttcagcgct gaaacgttct atgactttat 755881 ctgcaaagcc ttctttaacc gtcatttttc tcaactgtac aaacatttgt ctcactccaa 755941 tcattctcac atatgaataa ttgtaaatga aattcattct caatgtcaaa gaaagcgcag 756001 ggcggaatcg aaccgccgtg cgcaacagtt tattctttta ataaaaacac atttccgtct 756061 tcgtccttaa attgaacgaa ggtgccccac tccatttgat tgggctcacc gagaaattct 756121 acaccgtttg tcttcatttt ctcgtatgta ccaaagatgt cttcgcattc aaacacaata 756181 gaagccttca tttgctctga gcctttcatc atggctttcg ggtaaatgac taaacgagtc 756241 tcggctcctt ttggcgcaac ctccagccag cttgcttcag gtcccattgg gtgatccgct 756301 gcaatatcaa agcctacctt ctctgtccaa aattgcttcg ctttctgctg gtcctcgaca 756361 tatacagcaa cagtgccaat ttgtttgatc atagggaaac ctccaagttg aaaagataat 756421 aatactataa cctgtttacg gccgaagtaa cataaaaaaa tcagccggga aaccggctga 756481 ttattaaaat gagcagctta caacatcgat gtgatttgtg tctaaggcga aataaaccca 756541 gcggcgccgt gaggaatccc aataaaagcc gccgacggat cttctgccaa ggatgatcgg 756601 gtaaaaccaa aatgagcggc cattggttaa ccagacatag gtaaatcgga aaaggcaagg 756661 acgaatggtg attggttcaa ctaacaaaac ggctccttga gaaccctgcg gttttggggg 756721 tttcgctggt atttgggaag gaggaggtcc ctgcggcgca ccgccgaagc ctgggctggc 756781 accgctgcca ataccagggc cggagccgcc gccaaagcct ggaacagcac caccgccaat 756841 gccaggaccg gagccgccgc cagagcccgg aacagcgccg ctgccaatgc caggccatgg 756901 atatcggtat tcatattcaa aagcaggcca aggctcataa aaatgccccg caaacatata 756961 aggatcaaca taatacatgt gataacgtcc tttctcattg taaactgtac attgcagttt 757021 atgcgggcgg actcttattg gtgcattcgc ctaaggatat gaagctggaa tgctctcaga 757081 gagcagaatc atttgatttt tctctagtct tattcacaat tccgatttat cattttataa 757141 tgaaagtgct tctattacga aaaaggagac agaccgtgaa tatcgatcaa ttattatatc 757201 aatatatcat agacaacact gcggatatta ctgagaaatg gttcagtttg cgttgccagc 757261 taaaaggcga gctatattcc gccagccatt taagtgaaga aacgaaaaca cttttaaccg 757321 agcagcatac atttaccaat ataacaatcg caagcgcatt tctggaggat caaaccgatt 757381 ttcaagaaaa catgacaaaa tgggcgcaaa acgttgcgaa aaacagggta gagcaggatg 757441 ttcaagtgca tgaggtcgta gaagccatat ccaattcaag aatctcattc tgggacgcag 757501 tcgccacatt tataaaagag aatcaggaga ttgtgacaaa tgaggatgca gaccgatgga 757561 accgcattgt gaatcagtcg ttcgataagc tgattattga attctccgag cagtaccaaa 757621 aattcatgct gatgaggctt acatctcagc aggaactgat ctcagagctt ggctgcccgg 757681 tcatttccat tgccgatgga atcgggatat tgccgcttat cggctccatt gatacaaaac 757741 ggcacaggtc attttagaaa cagtgccggt ccgctgtgtc gagagaaaaa tcacaagcct 757801 cgtcgttgat ctttcgggtg ttccgattgt ggataccatg gtggctcagc aattgtacaa 757861 cctgtctaaa acacttttct tattaggcgt caaagccgta ttttcaggaa ttcgcccgga 757921 tgtggcccaa acatcgattc aattggggct tgattttagt gaatatgaaa cgtacggcac 757981 gctgaagcag gcattagaaa acatgggtgt ccgctgtatt gttgaggaat tggaagaaaa 758041 caaataggaa gtttccaggc atatgattgt ccgtcaccgg gtgatcatat gcctttttga 758101 tttgaacaga aatcaccatt gatttatcga aaaaaacata atattataat tcttataaga 758161 atactgtgaa ttaaaaccta ttcaacaggg gggaaggtct tttggtttct aaatcaacga 758221 ttgatccgga agtgattgaa aaaatcatca gctcgctgga aacactcgat ttcggcacgg 758281 ttcagattac ggttcatgat tctcagatta cccaaattga gaaaatagaa aagcaccgtt 758341 tttcgctgaa aaggaaagaa tcaaaatgat aatgtaaagg gcgtttgttt tcattaaatt 758401 ctccttaaaa catatacata tttcatccaa tttttatata atagaccttt aagatcattt 758461 tttaggagga tttttgacat gcaagctacg gttcacgaga gtaagcaatc gatcatgcaa 758521 cgcattttga cagtctttgt cttcacattg ctgatcgcga ctgtcggcct ttttatcggc 758581 caatttgttc ctgtcgcttt gatgctgccg ctttctattc ttgaagtggc gatgattatt 758641 ctggccttct ggatgcgcag aagaaaagcg gtcgggtatg cgtttgtata tacattcgcg 758701 ttcgtttccg gcattacctt atttccgatc gtcagccatt acgcttccat cgccggcgcc 758761 tatgtcgtgc tcgaagcctt tggctctaca tttgtcattt ttgccgtctt gggcacaatc 758821 ggcgcaaaaa tgaagaagga tttatccttc ctgtggtcgt ttctgctggt tgcggtgctc 758881 gcactcgcag tggtagggat tttcaacatt ttcagcccgt taaactcagc ggcgatgatg 758941 gcgtattccg tgatcggaac catcgtcttt tccctttaca ttttgtatga tttgaaccaa 759001 atcaagcacc gccacattac ggaagacttg attccggtta tggcgttatc gctgtaccta 759061 gactttatca acttgttcat caacctgctc cgcttcttcg gcattttgag cagtgatgat 759121 taatgaaaaa gcgtctgtca ttggataggc gctttttgcc atacatcaaa aaggcaggtg 759181 gagtattggt gaaaaaacaa atgggcgcat atgtatctct ggcagcagct atggcgatcg 759241 tcggcagttc tgtcgttgtc ggcaagctga tggtcgaacg gattccggtc tttctttcct 759301 caggattgcg ttttttgatc gcttctgtcg tattgctcat gctgctgttt tgcattgaaa 759361 aagggtttcc ggctttgacg aaaaaagatg tgttcgtatt actggtgcaa tcattcacag 759421 gcgtgttttt gttcagtatt tgcctgctgt atggggttca atatacgacg ggaacggaaa 759481 gcggcatttt gacaagcaca acccccatgt tgatcggtat tttatccttt ttcctgctga 759541 gagaaaaaat tgagaaaaag acgctgatcg gcattttgct ggcggtttgc ggcgtaatgg 759601 cgattaattt gtttggagcc gggagccaag acgggacgcc gcacgcctta ttcgggaaca 759661 tgctgatcat tgctgcagtc attggcgaag cgttgtttac attgatggcc aagctgctat 759721 ccccgcatat ttcggcactg gcgatttcga ccttcgtatc gctcttcggc ttcctgtttt 759781 ttctcccgtt tgctttgttt gaggcctctt catttgatta cagcgtgccg actgttttgg 759841 attggtcgta tgtgctgtat tacgcgcttt ttgtcactgt tttggcgttt tacttatggt 759901 atagcggggt gacgaaggtg ccggcgggtg tatcgggcat tttcacatcc gttcttccgg 759961 tctcagctgt cattttgtca ggcgtgatat tgaaggagcc atttgagttt gtgcatttca 760021 tcggcattgc atgtgtcatc ggcggcatat ttgttacggt cataaagaaa aaacagccgg 760081 atgcgtatcc ggctgcagaa gaaaagacgc tatagcctgt ccggatcgga cgggtttttt 760141 agtctttaaa cacgctcagc ctttcaaaaa gatcaccaag catcttcacg aacatgtctt 760201 tttcctcgtc gctgtagttt tccatgacag cggatatttt gctgaaatgg ccgggcagaa 760261 attgctccag gcgtgctttg ccttctgttg tcagttcaat gctgattttt cgtttatcct 760321 ctgtgtgatg cctgcggctg acaaaaccgt ctctcgccag cccgtctagc aggcctgtaa 760381 ttgttgcttt cgtgacattt gaccgcttgg caagctctgt cggacttaac ctatgatcct 760441 tggcatcaaa gagcagcatc aggattttga attttccttc tgaaagccct cggccagcaa 760501 agtaatgctc catcacatga ttcatttttt ttgaaatatc aaaaagagat aaaaacaatt 760561 caagagagcc ggcgtcaata ttggcatacg tttcggcgtg ctctgttata tgcttatatt 760621 tcggtaaatg ttttaattcc atcgcaatta gctcccgtac attcgttgtg acacgattat 760681 aaaggaggga aaaccataac gcaacttggc ttggagatga ttgacagctt ttcttgggac 760741 atagtaaggt aatatagtta ggcgcctaac taatacatat agagctgaaa aggtggttat 760801 tgatatgaaa catatgttaa tagcaggagg cggaatcggc ggcttgtcag cggccatttc 760861 tctccgtaag gcagggtttt ccgtcacctt atgtgaagcg gcttcagaaa atcgaaaaac 760921 aggtgcgggg attcttcagc cgcaaaacgc actggcggtg ttgaaagaac tgggcgtatt 760981 cgaagattgc tgtaagcacg gctttcaaac agaatggttt aaaacgtttg atgaacaggg 761041 gaatttgctg tttcaagtca gtgaatcctt tttagacgat tcacttccgg gacgcaataa 761101 tatcctgcgc aaaacgttaa atgacattct catgaagcat gccgaggcag tgggtgtaga 761161 catcaagtgg gggaaaaagg ttgtcgccta tgaagaaact gctgaatcgg tcactgcctt 761221 atgtgaagat ggagaaaaga tgcaggctga cattctggcg ggctttgacg gcattcactc 761281 cgttgttcgt gataagatgc tgcaaaagga aacggaaaaa gagcatctcg gcatgggagc 761341 gtggcgcttt tatatcgaac ttcctgatta cacattcgag gacgcaacat tcatgtatag 761401 aagcggagac acacaaatcg gggtggtgcc attggcacaa cacgctggct atgtcttcgt 761461 cctccagcct tgcacgagcg attactggga tgaggaagat acccggtttg atagagtaaa 761521 agagattctt tctggttttc gggggctgga ttttgtcaca aagcacatgt caaaacagca 761581 tcctgtcatc tttaacaaac tggagcaggt cgccgtgcag gagccatggc ataaaggccg 761641 cgtcatcatc ggaggagacg ccgcccacgc cggtgcgcca accctggcac aaggagcggc 761701 aatggcgatc gaggatgcca tcgtcctcgc cgaagaactc caaaaccacg ccgaccacga 761761 aacagcatta caggcgtact ataaaagaag agccccacga gcgctcaaag tccagaacct 761821 atcatctgaa atcgtccgcc gcaggctgaa aggagagccg ggagcggaag aactgattgg 761881 ggagtgctat gcggtgttga gggaagggta ttaaatagga aaagtccaga aagtgatttc 761941 tggacttttt agtcttgctc tgttttattc cttatccgct caatcacctc atgcagcccc 762001 tcaggcttat aaaactccac cggtgaactg cctttctcaa acgaaatcgt ctcggcttca 762061 atcagcgcga catagcgccc gtttactttt gcgagatgaa tagaatcgcc aaaatccgct 762121 agcaatccct taatctctgt ttctccgact ttcattttca gctgggcctc tggcgtgtgc 762181 tcgatgattt gggcggaggc ttcgatgact tgatgggtgt cgaggcgctc ttggatttcc 762241 cgtttttcgc ttgcttccca aatctcaatg tcgtgctcga actgcttgag ttcttcgctg 762301 ttgtcttcaa atgtctcgta gacgtgctct tgtaccatgt tcatgacctg atttttcatg 762361 atttctggca tcgattctcc gtactcgacg aatttcagaa agtcctcaaa atagcgggcg 762421 tgcgaggcct ggtggatttt cagttcacct tcctcgacca ttccttcctc tggcatgtac 762481 gggtattgga tgcttttcat gttttttgtc gtgatcgcca tttcgacttt tttaatgaga 762541 gaagacgcgt cagagatgcg ggcgaccttc ggctcaaaat cacatttcat aatgaagaca 762601 aatgactcat caaagtattt tctcggcacg gccgaagcga cgagaaacac gccgccgcga 762661 accgcgcttg tgtcaaggta cgtgcggacg aactgctcgc tcagctcatt gaagtcttct 762721 tttgtttccg ccagacgcgc gcggttgaac atgttgtagt ttgggttgga atcgagctcg 762781 tggccgggct cgacgataaa atggccgatt ttcgtcggca cctgctcgga ctgcggatgg 762841 cggtcggctt tccgtttaac gatttttttc agttccccgt cgagaaagtc cttcagctcg 762901 ctttcttcaa attctcccgt atcaagggtc tggaagtgct tgaactgctt gttcgcctgc 762961 tcatctttgc cttccacctg tatgacataa aaggataaaa accgaatttc aaaatccata 763021 tataaactca ccttattcgc gtattgtaca gcttctcaag tatagaaaaa acagcgatca 763081 tgcgtcaatt gggagaacgg aataatcatg accatgaaag ggaaatgtag tcaaatagaa 763141 ggcatttcat acggaaagga atggttcgat gaaggaaaca agcccgattc ctcagccgaa 763201 gacgtttggg ccgctcggca atttgccttt aattgataaa gacaaaccga cgctttcgct 763261 gatcaaactg gcggaagaac agggcccgat ttttcaaatc catacacccg cgggcacgac 763321 cattgtagtg tccggccatg aattggtgaa agaggtttgt gatgaagaac ggtttgataa 763381 aagcattgaa ggcgccttgg aaaaggttcg cgcattttcc ggtgacggat tgtttacgag 763441 ctggacgcat gagcctaact ggagaaaagc gcacaacatt ctgatgccga cgttcagcca 763501 gcgggccatg aaggactatc atgagaaaat ggtcgatatc gctgttcagc tcattcaaaa 763561 atgggcaagg ctcaacccga atgaagcagt cgatgtcccg ggagatatga cccggctgac 763621 gctcgacacc attgggctat gcgggtttaa ctaccgcttt aacagttact acagagaaac 763681 gccccacccg tttatcaaca gcatggtgcg ggcgcttgat gaagcgatgc atcaaatgca 763741 gcggcttgat gttcaagata agcttatggt cagaacaaag cggcaattcc gctatgatat 763801 tcaaacgatg ttttcgttag tcgacagcat tattgcagag cgcagggcga atggagacca 763861 ggatgaaaaa gatttgctcg cccgcatgct gaatgtggaa gatccggaaa ctggtgaaaa 763921 gctcgacgac gaaaatatcc gctttcagat catcacgttt ttgattgccg gccatgaaac 763981 aacgagcggc ctgctttcct ttgcgactta ctttttattg aagcatcctg acaaactgaa 764041 aaaggcgtat gaagaggtcg atcgggtgct gacggatgca gcgccgacct ataaacaagt 764101 gctggagctt acatacatac ggatgatttt aaatgaatca ctgcgcttat ggccgacagc 764161 tccggctttc agcctttatc caaaagaaga cacagtcatt ggcggaaaat ttccgatcac 764221 gacgaatgac agaatttctg tgctgattcc gcagcttcat cgtgatcgag acgcttgggg 764281 aaaggacgca gaagaattcc ggccggaacg gtttgagcat caggaccaag tgcctcatca 764341 tgcgtacaaa ccattcggaa atggacaacg ggcctgtatc ggcatgcagt ttgcccttca 764401 tgaagccaca cttgtgttag gcatgattct aaaatatttc acattgattg atcatgagaa 764461 ttatgagctt gatatcaaac aaaccttaac acttaagccg ggcgattttc acatcagtgt 764521 tcaaagccgt catcaggaag ccattcatgc agacgtccag gcagctgaaa aagccgcgcc 764581 tgatgagcaa aaggagaaaa cggaagcaaa gggtgcatcg gtcatcggtc ttaacaaccg 764641 cccgcttctc gtgctgtacg gctcagatac cggcaccgca gaaggcgtcg cccgggagct 764701 tgctgatact gccagtcttc acggcgtaag gacaaagaca gcacctctga acgaccggat 764761 tggaaagctg ccgaaagagg gagcggttgt cattgtgacc tcgtcttata atggaaagcc 764821 gccaagcaat gccggacaat tcgtgcagtg gcttcaagaa atcaaaccgg gtgagcttga 764881 gggcgtccat tacgcggtat ttggctgcgg cgaccacaac tgggcgagca cgtatcaata 764941 cgtgccgaga ttcattgatg agcagcttgc ggagaaaggc gcgactcggt tttctgcgcg 765001 cggggaaggg gatgtgagcg gtgattttga agggcagctt gacgagtgga aaaaaagcat 765061 gtgggcggat gccatcaaag cattcggact tgagcttaat gaaaacgctg ataaggaacg 765121 aagcacgctg agccttcagt ttgtcagagg gctgggcgag tctccgctcg ctagatcgta 765181 cgaagcctct cacgcatcca ttgccgaaaa tcgtgaactc cagtccgcag acagcgatcg 765241 aagcactcgc catatcgaaa ttgcattgcc gccggatgtt gaatatcaag agggcgacca 765301 tcttggcgta ttgccaaaaa acagccaaac caatgtcagc cggattcttc acagattcgg 765361 tctgaaggga accgaccaag tgacattgtc ggcaagcggc cgcagtgcgg ggcatctgcc 765421 attgggccgt cctgtcagcc tgcatgatct tctcagctac agcgtcgagg tgcaggaagc 765481 agccacaaga gcgcaaatac gtgaactggc gtcatttaca gtgtgtccgc cgcataggcg 765541 cgaattagaa gaactgtcag cagagggtgt ttatcaggag caaatattga aaaaacgaat 765601 ttccatgctg gatctgcttg aaaagtatga agcgtgtgac atgccgtttg aacgattttt 765661 agagctttta cggccgttaa aaccgagata ctattcgatt tcaagctctc caagagtgaa 765721 tccgcggcaa gcatcgatca cagtcggtgt cgtgcgcggc ccggcgtgga gcggccgtgg 765781 cgaatacagg ggtgtggcat caaatgattt agctgagcgt caagccggtg atgatgtcgt 765841 gatgtttatc cgcacaccgg aatcccggtt tcagcttccg aaagaccctg aaacgccaat 765901 tattatggtc gggccaggca cgggagtcgc gccatttcgc ggtttccttc aagcccgcga 765961 tgttttaaag cgggagggca aaacgctcgg tgaggctcat ctctattttg gatgcaggaa 766021 cgatcgggat tttatttacc gagatgagct tgagcggttt gaaaaagacg gaatcgtcac 766081 tgtccacaca gccttttccc gaaaagaggg catgccgaaa acatatgtcc agcatctcat 766141 ggctgaccaa gcagatacat taatatcaat ccttgaccgc ggtggcaggc tttatgtatg 766201 cggtgatggc agcaaaatgg ccccggatgt ggaggcggca cttcaaaaag cgtatcaggc 766261 tgtccatgga accggggaac aagaagcgca aaactggctg agacatctgc aggataccgg 766321 tatgtacgct aaggatgtct gggcagggat atagataaag aagactggag acatccagtc 766381 tttttagtcc tttcgaaaaa atggtgatcg cgctaaacat tgatgcatac aataacttca 766441 gtccgccgga agggcgggct gtctgcaaaa cctatttttc gtttttgcta gtttatgtta 766501 ttcttatact cggtatctat ttcttttttc aaaggcacac atgacaaaag aaatcctttt 766561 tttatttccg agaaaaaaat gtgaaacgaa atgaaggttt ctttcgtcca gtgattggtt 766621 tccaaatggt tgtaataaaa atgatatggt gcgaaacata aatattccgg cttgccgcgg 766681 tgtatttatt gttgtgtgat gccttgattt tgtttggaaa gaaggaattg gaaggcagga 766741 tataaagagc aggtaaatat gaatgaagaa cttaaagtgt ttaagaaagt agaggttgcc 766801 atgaagaaac ttttttctta caaacttagc ttttttgtgc tggctgttat actgttttgg 766861 gcaaaaacgt atttatccta caagactgag tttaatcttg gggtaaaagg cacaactcag 766921 gagatcctcc tgatatttaa cccattctca agcgccgtct tctttttagg actggctttg 766981 ctggcgaaag ggcgtaaatc agccattatt atgctgatta tcgatttctt gatgacattt 767041 gtgttatatg caaatatttt attctatcgt ttctttgacg atttcttgac gttcccgaac 767101 attaaacagt ccggaaacgt tggaaacatg ggagacggga ttttcagtat catggccggt 767161 catgatattt tctatttctt agatattatc attttgattg cggtattgat ctggagacct 767221 gaattaaaag aatacaaaat gaaaaaacgc tttgcatctt tagtgatcct ttctgggatc 767281 gcactgtttt tcatcaacct gcactatgcg gaaaaagacc gtccgcaact gctgacaaga 767341 acgtttgacc gcaattatat tgtgaaatat ttaggtttat acaactacac catttatgac 767401 ggtgtacaga cggctcaaac agagacgcaa agagcctatg caagcagcga tgatttaaca 767461 agtgtcgaga attacacgac gtctcattat gcgaaaccaa acgccgagta cttcggctct 767521 gccaaaggca aaaatatcat taaaattcac ctcgaaagct tccagtcatt cctgattgac 767581 tacaagctaa acggtgaaga ggtgacgcct ttcttaaata aacttgcgca cggcggggaa 767641 gatgtgacgt attttgataa cttcttccat cagacaggcc agggaaaaac atctgatgcc 767701 gagctgacaa tggataactc gatcttcggt cttcctgaag gctccgcgtt tgtgacgaaa 767761 ggcgaaaaca cctaccagtc gcttcctgcg attttagacc agaaggaagg ctatacaagc 767821 gccgtcctgc atggtgatta caaatcgttc tggaaccgtg accagattta caaacatatc 767881 ggatatgaca agttcttcga cgcaagcacg tatgatatgt cagatgaaaa tgtgattaat 767941 atggggctta aggataagcc gttctttaca gaatcgattc caaagcttga atctcttaaa 768001 cagccatttt atgcgcattt gattacattg acaaaccatt atccgtttaa ccttgatgaa 768061 aaagacgcgt ctcttaaaaa agcgacaaca ggcgataaca cagttgacag ctacttccag 768121 acagcgcgtt accttgacga agcgcttgag caattcttca aggagctgaa ggaagccggc 768181 ctgtatgaca actcagtcat catgatttac ggtgaccata acggtatttc tgaaaaccat 768241 aaccgagcga tgaaagagat tcttggaaaa gagatcacag attatcaaaa cgcacagaac 768301 cagcgtgtgc cgctgatgat ccgcgttcct ggcaaaaaag gcggagtgaa ccatacgtat 768361 ggcggcgaaa ttgacgtcat gccgacactt ctgcacttag aaggaattga ttctcagaaa 768421 tatatcaact ttggtactga tttattctct aaagaccacg acgatacggt ggcattcaga 768481 aacggagact tcgtaacgcc gaagtacaca tcagtcgaca atatcattta cgatacgaag 768541 acaggtgaaa aactgaaagc gaatgaagaa acgaagaatc tgaaaacaag agtgaaccag 768601 cagctgagcc tttcagacag tgtcctgtac aaagacttgc tgaggttcca taaactaaat 768661 gatttcaaag ccgttgatcc gtcagactat cattacggca aggagaaaga aatcaaataa 768721 gatgaaaaag agccttgagc gggcgcattg ccttcgctca aggctctttt tttggttata 768781 caaccaactt gaaaaaatag attccatttg gtcaccaagg ctggctttct ctcatatcat 768841 tacagtagat tttgaaaccg gattgaaatc ggacaaatta tcggggaaat gccttgatag 768901 attgtgaaga tgtaccaggt ttcgaactca atattcatag agatgagggg tagagatgaa 768961 agcggtcatt ctctgcggcg gaaaaggaac gagaatgagt gaagtcacga atgacattcc 769021 taaaccgctc gccatgatag gcggcaaacc gattctatgg catattatga aaatttatca 769081 gtactacgga gtaaacgagt ttattctgct tttgggctat aaaggagaaa aaatcaagga 769141 atactttctc gactatgaat ggaagcacaa cagcctgaca ctcgacagct ctacgggaga 769201 ggtacagatg ctggggcagc ctgaaacgtg gaaaattacg tttttggaga ctggggtaga 769261 tacgctgaca gccggaagaa tcttgcaggc gaaagactat atcggtgatg aaacatttct 769321 gctcacctat ggagacgggc tggccaatat caatcttttc catctcatca gctatcatca 769381 gacaaaaggt gctgccgcga ctgtcaccgg cattgacaaa gtctcgcagt ttggcacctt 769441 gacagttgag gatggcatgg cgaaaacatt ttctgagaag acatcaagtg atggaatcat 769501 caacggcgga ttcttcgttc ttagtccaaa ggttttcgat tatttgccga aggacgggaa 769561 cacgatgttc gaagatgaac cgctgaagaa ccttgccaaa gatggggagc ttgctgtgta 769621 ccgccattac ggattttgga cggccatcga tacgtataaa aatctcttag aagtcaacaa 769681 aatgtggaat caaggacaac aagtatggaa ggtatggtga attgatttga gtttctggaa 769741 aaataaaaac gtatttgtca cgggatgcac aggtctttta ggaagctatt tggtgaaaga 769801 gctgatcgaa cagggcgcaa acgttacggg gctagtcagg gatcatgtgc ctcaatccaa 769861 tctttatcag ggagaacata tcaagaaaat gaacatcgtg cggggctctc ttgaggactt 769921 ggctgtgatt gaacgcgcgc ttggcgagta tgagatcgac acagtctttc atcttgctgc 769981 acaagcgatt gtcggcgtgg caaaccgcaa cccgatttct acctttgaag cgaatatcct 770041 cggcacctgg aatattctcg aagcctgccg caagcatccg ttaattaagc gggtcattgt 770101 cgcttcaagt gataaagctt acggcgatca agaaaacctt ccatacgatg aaaacatgcc 770161 gctgcaaggc aagcacccgt acgacgtctc aaaaagctgc gcagatctga tcagccacac 770221 ctattttcac acgtacgggc ttccggtctg cattacgcgc tgcggaaact tatacggcgg 770281 cggagatttg aacttcaacc gcatcattcc tcagacgatt cagcttgtgc tgaacgggga 770341 agcgccggaa atccgaagcg acggcacatt tgtacgggac tacttctata ttgaagacgc 770401 cgttcaggct tatctgcttc ttgcagaaaa aatggaagaa aacaatcttg ccggagaggc 770461 ctttaacttc agcaatgaga tccagctgac cgtacttgaa ctggtagaga aaatattaaa 770521 gaaaatgaac agtaatctga aacctaaggt gctgaatcag ggaagcaatg aaatcaaaca 770581 tcaatattta tccgcggaaa aagcaagaaa gctgctgaat tggacaccgg cctacactat 770641 tgatgaggga cttgaaaaaa cgattgagtg gtatacggaa ttcttcaaaa agtaatgtga 770701 aacgaggtga acaagactgt gaccagcgcg tattgcaccg ttttatcaaa aggaagatta 770761 tatcaggcag tcgctttgtt taagtcgtta gagcaagttg atcaagacag tcccattttt 770821 atactttgca tggatgaaga tacgcaccgc gtgttacaga agctgaagat gaagcagctg 770881 aaccttgtgc cggtggccgc tcttgaaaat gaattgctgc tgaagctgaa ggaaactaga 770941 gatcaaagtg agtattgctg gacgatgaag ccgatctttc tgcaagctgt gctgaacagc 771001 aatcctgagc tggagcgtgt gacgtatatt gacggggatc tctttttcta tgcagatcca 771061 tcgccgattt ttgaaaacca gccggactgc tcggtgttgc tttcacgagg ggatattgta 771121 atcccttctt ttgagaaaga gcagattgac atgctgcagc gtcttttagg cagatataat 771181 tccgggttta tcagcttcaa gcatgatgat gcaggcacgg attgcttgga gtggtggaag 771241 gaacgctgtc ttgaggaatg caaaaatgca ccgggtgaag ggaaattcgg tgatcagggc 771301 tatttggatt atatgtctga gctgtttccg aatgtgtgtg acattacaac acccggcgtg 771361 aacatcggcc attggaatta tggacagcat acgttttcct ggaaagatgg ccggatcgtg 771421 ctggaggatg gcagtccgct gatcttttat catttcagcg gataccgaat cgtcagcatc 771481 aatgaaatca aacagattca tgaaacaacc cgcacagatc tgccgtttgt gcatgaactg 771541 tatcaagaga cactgccgca tatcattcag cacatgcaaa cgttagaccc tgaatttaac 771601 ggttttgctt caaaagatga caacaaataa atgagtaaat acaggaagtg aaaatgaagt 771661 gaaagcaagc gttattattc ctgcatataa ttcgaaggag cgtctttaca acagccttct 771721 gtcattaaac cagcaggagt gcgatgaaga atttgaagtc attgtagcgg acaatggctc 771781 tgaggacggg acgctctcga tgcttgagtc atttcaagct gattttccgc tgatctttac 771841 acggattaaa gaaaacaggg gcattgcgta cggacgaaat caggcgcttc gcaatgccag 771901 aggagacatc ctgattttcc atgacagcga tatgcttgcg gcaaaggacc ttgtggcaaa 771961 acatattaaa gcccatgaga acgaagagaa tctcgtcgtg tgcgggttgt tttggaaacg 772021 gatctacagt ttttactatg aacgatttga agaagaacat aaggaacagc tcgcaaagct 772081 cacaggtgaa atgccgaaga aagacaaaca aaagctgctg gaggaagcgg acatcaaaaa 772141 cggaagcttt cttgataaaa gctttgacct cgataccgac tttatagacg tgctcaagaa 772201 gattttagat gagtacggcg atgacttgaa aggctatcat atgccatggc gcttttttat 772261 cacgaataat tcctctgtga aacgcaagca tgtggttgac ctcggtttat ttgacgaagg 772321 cattgtgcgg tacgggtttg aggattatga cctcgggatc aggcttcatc aggccggatt 772381 gaccttcagg cttcgccgtg atattgtcag tgttcatcag gaacatccaa gcaattgtaa 772441 gtctgtagac gatattcggg caaacattgc ctatatgtgc gataaataca ataacatccg 772501 ctccttagac gttcatctcg cttttaatgg gccgttcccg cctgacatga cgaacagaat 772561 catggctgat attcaaaagc tgctggaatc acagaaatat gatatgctgc tgaatctgtt 772621 tcttgagctt ctgcatgttg ttaaagagcg caacattgat ccggattggc gaaagaaatc 772681 cccaagggtg acggcgaaaa gctttgattt gcaaactgtc cgcaagcttc tgcctaaggc 772741 gaagaaaaag ctaggcgtga acgattttgc caacgcactg tatgcgcttg tcaacgattt 772801 gctgcacgtg gatcttagat cattggatgt ggtataagtg agtacatttc atttttcaac 772861 gatagtgtca aggacacata tctttaagct catgcctatg attcattctc tccatgagca 772921 ttgcgatgat tttcatttat atgtgctgtg tgtcgaccag aaagcgtatg aattgcttca 772981 gcacgttcca tgggagcatg taacctttgt gcagctgcat gaaatggaag acccggagct 773041 gttgaaagcg aaaagcaaca gaacgtttca tgaatattgc tggacgttaa agcccgcctt 773101 tttgtttcat gtgatgagca agtgggatga cgctgaatac tttgcccata tggatacgga 773161 tctatttttc ttttctgatc cggcacgtat ttttgcagaa aacccaacgg cgtctctgta 773221 tttgactgat catcgtaatt cgccgcgctt catgtcctac tacgaccgaa ccggacgctt 773281 taatacaggc tttgtcggcg ccggtaatac aaaggaagca tatgaagcgg tgtggcagtg 773341 gagacaggac tgtattgaat tttgcacggt cgaaatggat acggaacgaa agacatatgg 773401 tgatcaaaga tatgtggaga aatggccgga gcagtttaaa ggtgttcatg ttgtcaaatc 773461 cataggagcc aatacagcgc tttggaatat cgaaaactat aaggtcgggc aaaaggacgg 773521 ccgcgtgtat atagatgaaa cgccgctgat tttctatcat ttctctgggt ttacgctggt 773581 gacagaaaaa gagtttaatc tttgctggta ctaccggatt gaagacgaag cgacaattaa 773641 gatgatttat atgccctata tattaaatct gaaaagatgg attgatgaaa tacagtcggc 773701 gtttccggac tttgcggatg gctttatccc gaagcacgca gtgcctgaca ctcattttat 773761 ccagctggat taaaaaaccc cctgccgcct ggcaggggtt ttttcagcta tgccattctc 773821 tcagcttctg gtcacttggc aataggaagg caaggatgcc gaggacaggg agaaaggcaa 773881 tggcgatcat cgtcggggtc agtcccgcgg catcaatcag agcgcccagc gccacagcgc 773941 cgattgcgcc catcccgaag gcaagcccga cggttaaacc ggacattgtg ccgatttttc 774001 caggaactag ctcctgtgcg tagacgaccg ttacagaaaa gctcgacatc agaaccaagc 774061 caatcaatgc gagcacgccg taggcgagaa ccgggccggc aaatggcagc acaatcgcca 774121 gcggcgccga gcataacagc gaaccgagga taacgaagcg ttttccaaaa cggtctgcaa 774181 gcgggccgcc gagaaacgtg ccgatcgcgc cgaacagcaa gaagacaaaa atatagcttt 774241 gtgcctgctg aatgcttacg tgataggtat ccatcgcgta aaacgtgtaa aagttaccga 774301 tcgcactcgt ataccaagaa cgagcaaaaa tgagaaatat aataataata agagcagata 774361 caacagattt ggtgatggcc gtgttttcag ccgttttctt ttgcttgcct gatttctggg 774421 caaggctgcc gagacgtgag gcgtaccatt tcgcaatata catgagaaac ataacagcaa 774481 gcgcggcgac aagcgtgaac caaacagcgc cgaattgccc gagcggcaca aggatcagcg 774541 cggtgatcag cggtgccatc gcctggcctg agtttccgcc cacctgataa atcgattggg 774601 cgagcccgcg ttttgtgccg gcggccatat acgccacacg ggagccctcc ggatggaaaa 774661 tggccgagcc taatccaatg aaaaacacac agcataagat cgttatgaat gacggggcaa 774721 atgcaaggcc caaaatgcca agcatgctgg cggtcaaacc gactggcagc gcatacggcc 774781 gcggccgttt atcggtatac cagccgacaa caggctgcat gacggatgac accatgttta 774841 atgtgaaagc aatgatgccg agctgtgtaa acgtcaggct catggagcgt tccaaaatag 774901 ggaacatggc cggaatcaca gcctgaagcg aatcgttgag catatggcaa attccgataa 774961 taatcaaaat cggatacacc gtggtgcctg gtttttgaac tgttttttct tttaacgggg 775021 cggcgatagc cattgagtct cctccttaca tatataacca aagcatacca ccatattatt 775081 cataaggtga agaatttatc aagaggaaaa aagattctta tgaaagaaat accgtcagcc 775141 tgattagcag ctgacggtat tttcgatatt caaaatgtga tatagctctt caagcttacg 775201 aatctcatag gttggtatga tctctggcac attcggcttc atgtcagggt tcatccagca 775261 agtatcaagc ccggcgagct gtccgccttt gatatcagca gttagtgaat ccccgatgat 775321 taatgtgtgc tctgctgaaa attgaggaat ccgttcaaac acgtaattga aatattcctt 775381 catcggcttt tggaagccgg tgtcttcaga aacgaaaatg tccttgaaga atggaaataa 775441 tcctgaatca cggagacgct tatattgtgt gtgagacacg ccgtttgtca cgatgtacaa 775501 atcaaactgt tgctgcagat ttgagatgag atcaaatgca ccgtcaataa gctgatgtcc 775561 ttcttcaaga aagcggcggt atttttgctc aagcaaagcg ccgtccgctt cgtaaccgta 775621 ctccttgagc aaagcggaaa aacgtgtgtt tacgacttca tcccgtgtca tcttaccttc 775681 ttcaaaggct ctccagagac cttgattgat ggttttatac tgcgccttca tgtcatttgt 775741 taaaggaatg ttctgatctt caaacagcaa acgcagggct aaagcttctg ccgcttgaaa 775801 atcaaggatg gtatcatcta catcaaataa taaagtgcgg tatcgcttca tctgtgtgtc 775861 tccctttctc atatgtattc aaagtatagc acataaaaaa aggaaaaagc cggcgggtga 775921 ggcaccgccg gctgaaaaga gattatttgt ttaataagct gtgttttctc gaatatagga 775981 agtaaaccag cgttccgaca gcgatccaga tgacaaatga aagccatgtg acgccgggaa 776041 ggctgtacat gaaccaaagg cagatgcctg cgctgataat cggcacaacc ggaacgaatg 776101 gcactctgaa ggacgctttg atttcaggat gtttctttct taacacaatg acagcaatgg 776161 aaatgaccgt aaacgcggca agtgttccca tgttcaccag atgggccagc gttccgaggt 776221 taataaagcc ggcgattccc gctgcaacga tccctgtcag ccatgtgttg cggaacgggg 776281 ttttaaatga cggatgaacc tttgcgaaca atccaggcag aaggccgtct ctgctcatgg 776341 caaatgtcaa gcggacctgt gcgtacagca aagcgagcat caccgtcgta atcccgataa 776401 tcgcaccgac agaaataatt ccggcaacag cgtcctgtcc gacgaatttc agcgcaaagg 776461 atacaggatc tccgacattc aatttggcat aaggcatcat gcctgtcagc acaagcgata 776521 ccgcgatgta cagaaccgta cagacggcta gagctgaaat aatgccgacg ggcatgtttt 776581 tttgcggatt tttcacttcc tctgatgcgt tagaaaccgc gtcaaaccca aggtacgcga 776641 agaatacagt ggcagcgcta agtatgacgc ctttcatccc gaatggcata aaaggagacc 776701 agttatccgg tttcacatag ccgatgccga caataatgaa caataatatg atcgcgattt 776761 tcatcagtac gatgacgttg ttaaagcgtg tgctttcctt gacgcctctg ctgacaatcg 776821 cagtgatgag gagaatgatc accgcagccg gaaggttaaa tacggcgccc gccatgcttc 776881 ccggcgctcc tgtcagtgca gccggaatat gaagattgaa gccggcaagc agtgattgaa 776941 agtatgaaga ccagccggtg gcaaccgccg acagtgcaat gacatattca agcatgagat 777001 cccatccgat caaaaaggcg agcagctctc caagtgtcac gtatgagtat gagtacacgc 777061 ttcccgaaat cggaatggaa gacgaaaact cagcataaca gaaagcagcc agcgcacagg 777121 cgagccccgc taaaataaac gatatgatga gggcgggacc tgcaccggtc gctgccactg 777181 ttcctgtaat gacaaaaatc cctgtaccga tgacacaacc gataccgagc aaggttaaat 777241 caaatgcgct taacgtacgg gcaaggcttt ttgacttgct ctgcgcactc aatgtttcaa 777301 gcggtttttt tctaaataat gaactcatca aaagttcctc ctagaaatat tcaaaatatt 777361 ctaatcatta tatgcagttc ttgttgtatt atattgtcga aatttgacgt agtcaataaa 777421 atatttttct gctttaaatg atagaagcga aacagcgttg tcgtatcata ggatagtaat 777481 ttttactaat cgtatattca attttatgca agatgaaccg atagaaaaaa tagattcgcc 777541 catattttga tttgcggtta taaaggagat gctgaccatg tttcaatatg aagagttgaa 777601 taaacagttt atcggcggga aatggcagga gggcagcagc ccaaatgtat tggaaaacaa 777661 aaatccttat actcaaaaaa cattcacaac attccgtaaa gcgactgctg acgatgtaga 777721 tgaagcgtat cgggcagcgg cgctggcaaa gaaaaaatgg gatgcggtca acccgttcga 777781 gaaaagaacc attttagaaa aagccgtcac gtatattgaa gaaaatgaag aagccattat 777841 ttatttgatt atggaggagc taggcggtac aaggctcaaa gcagcttttg aaatcggtct 777901 tgtcaaaaac atcataaaag aagcggcaac gttcccaatc cgcatggagg ggaaaattct 777961 tccgtcaaca atagatggca aggaaaacag attatatcgc gtgccggcag gcgttgtcgg 778021 tgtcatcagt ccgtttaact tcccattctt tttatctatg aaatcagtgg cgcctgcact 778081 cggagccggc aatggcgttg tgctaaagcc gcatgaggaa acgccgattt gcggcggaac 778141 gctgattgcg aaaatttttg agaacgcggg aattccagcg gggctgctga atgttgttgt 778201 cacagacatt gctgaaatcg gcgacagctt cgttgagcat ccagtgccgc ggatcatctc 778261 atttaccggt tctacgaaag tcggcagcta catcggacag cttgcgatga agcattttaa 778321 aaagccgctt cttgagcttg gcgggaacag cgccttcatc gtacttgagg atgcagatat 778381 agaatatgcg gtcaatgcgg cggtgttcag ccgatttaca catcaagggc agatttgcat 778441 gtcagccaac cgcgtgcttg ttcattcttc tatttatgac aagttccttg agctgtacca 778501 ggcaaaagtg gaatcgctga aagtcggcga cccaatggac cctgatacga ttatcgggcc 778561 attaatcaac agcagacaga cggacgggct gatgaagact gtagagcaag caattgaaga 778621 aggcgctgta ccagtgaagc ttggcggatt taacgggacg atcgtggaac cgacgatctt 778681 aaaagacgtc aaaccgttca tgagcattgc caaggaagag ctgttcggac cagtcgtctc 778741 ctttatgaag tttgattcag aagacgaagc ggtggatatc gcaaacgaaa ccccgtttgg 778801 cttgagcggt gccgtacata cgtcaaatct tgagcgcggc gtggcttttg cgaaacgcat 778861 tgaaacaggc atgattcacg tcaatgacac gaccatcaat gatgaaccga atgtagcctt 778921 cggcggtgaa aagcaatcag gcctcggccg tttaaacggt gagtggagcc tcgaagaatt 778981 tacaacgctg aaatggatct cggtccagca cgaaaaacgc agcttccctt attaatgaaa 779041 aggagtgaat ggaattgacc ataaatacgg aaaaagaaac cgcagatatt ctggacgcat 779101 ttatcaaagt agccccttat ttaaacagcc tggttcagga tgatattaca atcggcattt 779161 atgatacgga aaaactgctc gtgaatatac cggccaaaac cttttcgctg aacgtaaaag 779221 ccggcgatcc gctgcaggaa ggggatatca tcacagatgc catccgcagc aatcagaaga 779281 agacgagcat ggttccgaaa gaattgttcg gcttcccatt gatcgcgcgt gccatcccgc 779341 tgcacgacga gaatggaaga gtcattggag gcgtcggcct cggaacgagc cttgaggagt 779401 cgtcaaagct gcatgatgtc gcggaaagct tatcagctgt tgttgaacaa acagccgcgg 779461 ctatttccga catttctgaa tcaattaacg ggttttcaac tcaaatgtcg ggcatttcct 779521 ctcaggcgaa aaaagtaagc gaaagcgccg gtgaaatcgc cgatatttca gtaactgtta 779581 aaggcatctc ggaccaaagc aatctgctcg gcttgaacgc cgcgatcgaa gcggcaagag 779641 caggggagtc cggaaaagga ttctctgtcg tcgcagatga gatcagaaag ctagcgacgc 779701 attcaaaaga aaatgtcggc caaattgacc agattacgaa aaaaatccac agcctgctga 779761 aagggctgga ggaatccatt gagtcgatta accagcatac agacggacaa gccgctgctg 779821 ttgaacaaat ttccgccacg atgcaggaga tttcaggaag cgcgcagcat cttgcgaaaa 779881 tggccgaaaa agcgcttgag gaagagtaag agaccgggga caaacatccc cggtcttttt 779941 cttatcctgc atttccatga aattcgtctg acgttttact agttttattc cagcggctga 780001 tttaaaatgt acacatgaac ttacgtgagg attgatagga accatgagca tattaaaagc 780061 ggaaaatctt tataaaacat acggagataa aacattattt gaccatatct cctttcatat 780121 tgaagagaat gagagaatcg gattaatcgg gccgaacgga acaggaaaat caacgctgtt 780181 gaaagtgatt gccggcttgg aatctatcga agaaggagaa atcacgaaat ccggaagcgt 780241 gcaggtcgaa tttcttcatc aagacccgga gctgcctgcg gggcaaacag tgctggagca 780301 tatctattcc ggtgaatcgg ctgtgatgaa aaccttgcgt gaatatgaaa aagcgctgta 780361 tgaactgggg aaagatcccg aaaatgaaca gcgccagaaa cacctgctgg cagcacaagc 780421 gaaaatggac gcgaacaatg catgggatgc aaacaccttg gcaaaaaccg tattgtctaa 780481 gctgggcgtc aacgacgtaa caaaaccggt caatgagctc tcaggcggcc agaaaaaacg 780541 ggtggccatt gccaaaaact taattcagcc cgctgatttg ctcattttgg acgagccgac 780601 aaaccatttg gataatgaaa cgattgagtg gcttgaaggg tatttaagcc aatatcccgg 780661 cgccgtcatg ctggtgacgc acgatagata tttcttaaac cgtgtcacca accgcattta 780721 tgagcttgaa agaggcagcc tctacactta caaaggcaac tatgaagtgt ttttagaaaa 780781 acgcgcggaa cgggaagcgc aggctgagca aaaggaaacg aagcggcaaa acctgctgcg 780841 ccgcgaactg gcttggctca gacgaggagc gaaagcccgc tccacaaaac aaaaagcgag 780901 aattgaccgg gtagagacgc ttaaagagca gacaggccct cagtcatcag gttcactcga 780961 ttttgccatt ggctcgcacc gtctcggaaa acaggttatt gaagcggaga acgtcatgat 781021 cgcttatgac ggccgcatgc tcgtcgaccg ttttaatgaa cttgtcatac caggtgaacg 781081 gatcgggatc atcgggccga acggcatcgg gaaaacaacg ctgttaaatg cccttgccgg 781141 ccgtcatacg ccggacggag gcgatattac gatcggacag acggtcagaa tcggctacta 781201 tactcaggat catagtgaaa tgaacggtga gttaaaagtc attgactata taaaagaaac 781261 ggcggaggtc gtaaaaacgg cagatggcga tatgattaca gctgaacaaa tgctcgagcg 781321 tttcctcttc ccgcgttcga tgcagcagac gtatatccgc aagctgtccg gcggggaaaa 781381 acgccgttta tacttgcttc aggttctcat gcaggagccg aatgtcctgt ttctcgatga 781441 gccgacgaac gatttggata ctgaaacatt aagcgttctt gaggattata ttgaccagtt 781501 cccaggcgtc gtcatcaccg tatcccatga ccgctatttc cttgaccgcg tcgtcgaccg 781561 tttgattgta tttgaaggaa atggtgtcat ttcccgcttt caaggctcct atagcgacta 781621 tatggaggag tcaaaagcga aaaaagcggc cccaaaaccg gcagctgagg aaaaaacggc 781681 tgaagccgag ccgaagaaaa aacggaaaaa gctttcttac aaagaccagt tggaatggga 781741 cggcatcgaa gataaaattg cccagctgga agaaaagcat gaacagcttg aagctgacat 781801 cgccgcagca ggcagtgatt ttggcaaaat ccaagagctg atggccgagc aggcgaaaac 781861 ggcggaagag cttgaggctg cgatggaccg ctggacagaa ttgtccctca tgatcgaaga 781921 actggaaagc taaaaagcgt ggccgcagca ggccgcgctt tttttcacat aatggacaaa 781981 aacgaaccgg cctgcttatg ttaggataaa gttgtgtgtc agcggcacat ggaaaactaa 782041 cggagatgat gaagtatgac atgggcgatc gtgatgttaa ttctcatgag tctggtgaaa 782101 atcgtattaa cctgtcttcc tacaggcgtc atagaatggc tgctcggcaa atttgaagtg 782161 cacgccaagc tgagtgacga aaatgcgagt ctctctctag atggaaaacg cctcgagggt 782221 gcagagaagc agaaagtgat tgatcaattt aacgaagcta tcttcctgga aaaatattat 782281 atctatccag gtgatgaaga gcgttattta catccggaaa acggcggcac gcctctggtg 782341 atagatacaa aaaaaggaaa aaaagacgtg aagctgttcg tgtaccgcta cgacgaccat 782401 atcgacgtcg tgaaacagta caagaagaaa gtgatcgcgt atcgagtgct ttctgaaagc 782461 cttcaaaaag agtctctgtc agtggcggga agtttagctt aaacaggaaa gtgaaagacg 782521 ggtgctgtat gctgctcgtc ttttttattg ttttttaaaa cttaacgttt acgttaaggt 782581 tcaaaaggtg tataatggta acagaaacgg cgaaggggga tttaccttgg aatggatgaa 782641 gattgatcaa gtggccaaaa gaagcgggct gacaaagcgg accatccggt tttatgaaga 782701 aatcggcttg attccggcgc cgaaacggac agacggcggt gtaaggcttt attcagagga 782761 tgatatggag gagcttgaga aagtcatcag cacaaaagag gtgctcggtt tttcccttca 782821 ggagcttcag catttcatgg aaaccagccg ccagctagag ttaaacaaag aggggtattt 782881 gttgtcactg gatcctaagg aacggaaaga aaaactggag gaaattcagg aaaccctgaa 782941 tcaccagctg gatttgattg atgagaaaat ccgcacattc caaagcttta aagaacgcct 783001 gcagggcatg aaaggcaaag cggaacgcgc cattcaatca atcgaatgaa aagtttgtta 783061 aacgctattt ttgtagcgtt tcttttaatg gaataaagat ggaggttagg tcaaatggat 783121 aagacaacac aagtgaatca gaaaacgggt ttgctcagcc agccaaaagc ggtatgggct 783181 gtcgcgtttg cctgtgtgat ttcttttatg ggaatcgggc tggtcgatcc aattcttccg 783241 gccattgccg cacaattgca tgcttcacct agtgaagtat cactcttgtt tacaagttat 783301 ttgcttgtaa ccggatttat gatgtttttc tcaggagcca tttccagccg catcggcgcg 783361 aaatggacat taattctcgg acttattttt attattgtgt ttgcggggct tggcggcagc 783421 tcaagctcaa tcgctcagtt agtcggctat cgcggcggct ggggattagg gaatgctttg 783481 tttatttcaa cagcgcttgc ggtcatcgtt ggcgtgtcag tcggcggcag cgcccaagcg 783541 attattttgt atgaggccgc gctcggtctc gggatttctg tcgggccgct tgcaggcgga 783601 gagctcggaa gcatttcatg gcgcgcaccg ttttttggag tatctgtcct gatgtttatt 783661 gcgttaatcg cgatttcttt catgcttccg aagctgccga aaccggcgaa acgcgtcggt 783721 gtgtttgatg cgatgaaggc actcaaatat aaaggcctgc tgacaatggc ggtatcggca 783781 ttcctataca actttggatt ttttattttg ctagcttatt ctccgttcgt actggattta 783841 gatgaacacg gtcttggata tgtcttcttc ggctggggcc ttctgctggc gattacgtca 783901 gtctttacgg cgccgctcgt gcacaaagcg ctgggcacag tgcgttcgct agtcgttctc 783961 tttatcgcct ttgcggccat tctcgttatt atggggatct ggacagacca tcagactttg 784021 attattacat gtatcgttgt cgctggtgct gtcctcggta tggtgaatac gatcatgaca 784081 accgctgtga tgggttctgc gccggttgaa cgttcaatcg cgtcttcagc ctacagctca 784141 gtccgcttca tcggcggcgc gctcgccccg tggattgcag gaatgctgtc agaacacttt 784201 actgcaagca caccatatac agtaggcgga atcgtcgttt ttgtcggcat gcttgtcctt 784261 ctcatgggac gtaaacatct tgctggaatt aaggcggggc attaataacg aaagacactg 784321 cgcatatgca gtgtcttttt attcgttata atgcatcata atcgaattgg tgcaggaaag 784381 gacaaccttt atgacacaat tttactattt tccggctgaa aactcccttt agaaaccggt 784441 tttttcggtc agcaagaacg gcgttcgcgg aaagggcatc cgcttcggtc aggcattgat 784501 gcggctggga tttatcttgc agaagctgag aatgtgtccg ttcatttacg attgccattt 784561 cagtgatggt tcatgctgta gaggggacgt ttgccatgga taaggcaaaa cctgacgaat 784621 atgatcagaa atgtttagaa acgctctatc aatacataca cagcgtcatg aaaaacagct 784681 tttctcggtc gagtggttta ccgcttggga agatgaggag gattttgagc tgtctgccaa 784741 aagagagctg acacttgatg aattcacatc tccattgcag ctcattttaa aagacagaga 784801 gcttttgaga atcgttcaga aaaaatggca gtaaaaaacc cgccctttag caggcgggtt 784861 tttttataaa ttaaagcact ttcgtcgtcc aagactcgca gttccacgtt tctgtcgcaa 784921 tatccatata aaagtctggc tcgtgggaaa tgagcagaat ggagccttta tattctttca 784981 gggcgcgctt gagctcttcc ttggcatcgg catccaagtg gtttgtcggc tcatcgagca 785041 ccagcaggtt tgtttctgag ttgattagct tgcacaatct gactttcgct ttttcgcctc 785101 cgcttaatac ggagacgcgg ctttcgatat gctttgtcgt cagcccgcat tttgccagag 785161 cggcacggat ttcatactgc gtataagaag ggaattcgct ccatacttct tcgatgcacg 785221 tattgttgtt tgtttccttg acctcttgct cgaaatagcc ggtatagatg tgctcaccgc 785281 gttcaacaga gccttcgagc ggctggattt caccaagcaa acttttcagc aatgtcgttt 785341 ttccgatccc attcgcgccg taaagggcga ttttttggcc gcgctccatg cggaggttga 785401 gcggacggga cagcggggaa tcgtaaccga tcacgagatc cttcgtttca aaaatcagct 785461 tgcctgacgt tctcgccggc ttaaagtgga attccggctt tggcttttct gccgcaagct 785521 cgatcatatc catcttatcg agtttctttt ggcgggacat cgccatgttt ctcgtgctga 785581 cacgcgcttt gttgcgggcg acgaaatcct tcagctccgc gacttcctgc tgctgctttt 785641 tgtaggccgc ttcaagctgc tgttttttca cctcgtagac ttccataaac tgatggtagt 785701 cgccgacata acgtgtcagc tcttgatttt caacgtgata aatcaggttg atgacactat 785761 tcaagaacgg aatatcgtgg gaaatcagga tgaacgcgtt ctcgtattcc tgcaggtagc 785821 gtttcagcca ttcaatatgc tgttcatcaa gatagttggt cggctcatcg agaagcagaa 785881 tttccggctt ttcaaggaga agcttagcga gaaggacctt tgtgcgctgt ccgccgctca 785941 aatcggtgac atctcgctct aaaccgatat cgctcaaacc gagaccgcgg gcgatttctt 786001 ccaccttgga atcaatgaca taaaaatcat tgtttgtcag cgcgtcttga atgacgccga 786061 cttcttcaag cagcttctcg agctcgtcgg gatcagcctc gcccattttg ttgtaaatct 786121 cgttcatttc ctcttccatc gcaaataaat aatggaatgc gtctttcagg acgtcgcgaa 786181 tggattttcc tttttccagc acggtatgct gatcaaggta tccgacacgg acattttttg 786241 accattcgac ttttccctca tcaggttcaa gctttccggt aataatattc atgaaggttg 786301 attttccttc accgtttgcg ccgatcaagc cgacgtgctc gccttttaac aggcggaagg 786361 aaacgttatt aaaaatggcc cggtccccga aaccgtggct taaatccttt acagataaaa 786421 tactcatgtt tacacctcta tcgttatcaa acacgcacaa tcggcgtgta atattcaccc 786481 ttttgattat aaaggaggat tcggaatgtt gaaaggtata ggaaagaaaa agaaaaattg 786541 cgttccgggc gaggttttga gatactatgg aatagatttc aggaattgag gagaacaaaa 786601 tgacgcaaac ttggccattt ttacataatg cacaatcatt tatacaagag aattggaatg 786661 cttccggctt tcaaaagcca acccctgttc aggagcaggc agcccagctg atcatggacg 786721 gaaaggatgt cattgcagaa tcgccgacag gcacagggaa gacgctggcg tatgcgctgc 786781 cggtcttgga gcggatcaaa ccagagcaaa agcatccgca ggcggtgatt ttagcgcctt 786841 cccgtgagct ggtcatgcag atttttcagg tgattcagga ttggaaagcg ggctcagagc 786901 tgcgcgcggc ttccttaatc ggcggggcga atgtgaagaa acaggtcgaa aagctgaaga 786961 aacatccgca tatcatcgtc ggcacgccag gcagggtgtt tgaactgatt aaagcgaaga 787021 aactcaaaat gcatgaagtg aaaacgatcg tgcttgatga aacggatcag ctcgtcctgc 787081 cggagcatcg cgaaacgatg aagcaaatca ttaaaacaac attaagagac cgccagcttc 787141 tatgtttttc tgccacgctc aaaaaggaaa cagaggacgt gctccgcgaa ttggcgcaag 787201 agcctgaggt gttgaaggtg cagcgaagca aggcggaggc agggaaagtg aagcatcaat 787261 acctgatttg cgaccagcgc gacaaagtga agctgctgca aaagctgtca aggcttgaag 787321 gcatgcaggc actcgtattt gtgagagaca ttggcaacct gagtgtatat gcggaaaaac 787381 tggcatatca ccacgttgaa ctcggcgttt tgcacagtga agcgaaaaaa atggagcgag 787441 cgaaaatcat tgccacattc gaagacggag agtttcctct tttattggcg actgacattg 787501 ccgcacgcgg tttagatatt gaaaacctgc catacgtgat tcatgctgat attccagatg 787561 aagatggcta tgtccacaga tcaggacgaa caggccgggc cggaaaagaa ggcaacgtgc 787621 tgagccttgt gacaaaattg gaggaatcta agctgaaaaa aatggcgaag aagcttggtg 787681 ttgagctgag tgaagctgtg tatgcaggcg gaaaactgaa gacgaaataa aaagaagggc 787741 gaagagccct ttttttgttg taaaataata gaaaagattt tgcgcggagg tgggaaaatg 787801 gcttcaatag acaggtttca agtaatgcag gagccagagc tgaaaatcct tgaacactgg 787861 tttgagaatg aggataccag acggagaatg gatgggatgc tgctattaga tgagtggtat 787921 gcacgagtaa ataaagataa acacgatact gtcatcatgg cgtatgatgg acagctgccg 787981 gcagggatgg tcgttattga gttcggagag gagcggacat atattggatt gatcgtcaat 788041 cctttgtacc ggcttaaagg gtatggaaaa cagatactgc aaaagctgat gaccgaacct 788101 gattttacta gcgtgcgaga atgggtggca tgcattgaag aagacaatcg aatcagttta 788161 gcttgctttc aagcagcagg attcacttta gaagacacgg aacctgatga agatggtttt 788221 cttacgctga ttcttcgcaa ctgatctcat cgaaacacaa aaggagggca aaaagccctc 788281 ccgttttcat cttcattcag ctcggatcac tgaccttgat cagctgtttc cctttatttt 788341 ctcccttaaa taaaccgaga aacgcgtcag gaatgttttc gaagccttct gtgatggttt 788401 cctcgtaatg gagtttacca gccttcagcc attctgccag ctgttttgct ccctcagaaa 788461 aacgatcgga gtagtcgctt acgataaagc cttgcatcag cgacttcgtt ttaatgagtt 788521 ttgattggac acgagggccc atgtcatctg cttcgctttc tgcgttatag gaagaaatgg 788581 cgccgcacac cggaatgcgg gcaaattcat tgagcagatt catcaccgcg tctgaaatcg 788641 gtccgccgac attgtcaaaa tacacatcga caccgtcagg acaagcgttt tgaagcgctt 788701 tttggatatc atccgctgtt ttgtaattga tggcttcgtc aaactgaagc tcctgtttta 788761 aatagtcgat tttttcatca gagcccgcga tgccgacgac tcgcgcgcct ttgattttgg 788821 caatttgccc gactgttgaa ccgacggctc cggcagctcc tgagacaacc acggtttcgc 788881 cttccttcgg gcgtccgatg tccagcaatc cgaagtatgc tgttaagccg gtcattccca 788941 aaatgccgag ataggccgaa gcgggagcaa ggcttgtatc aatttttcgc aaggcagact 789001 cgctcacagc ggaaaattcc tgccagctga gatttccgat gacgatatcg ccttttttca 789061 gatgattccc gtctgacaca acttcagcga taacccctcc agaaagcgct ttatccaagg 789121 cgaacggctc aacatatgac ttcgtatcct gcatacggcc gcgcatataa gggtcaaccg 789181 atacataaag cgttttgaca agcacttccc cttgcttggg ttcaggaacc ggaatggttt 789241 caaagcgaaa gtcttcatga acaggaatac cttgtggacg tcttgctaat tgaatttgct 789301 gctgagatgc tgtcattttc atcctcctat cacttggttg acaccactgt aacatggaca 789361 ggagaggaaa tacaaaaggt aagctggcat acaaaaaagg ttatagatga gcttatgctt 789421 tctacaagct cttttgtttt aaaagttctc tttagtcatt tatcattatt agaaaacaga 789481 acagaaaaag agctcctgta cacctagcta agattggcta gtgtgtatgt cgattctttt 789541 tcatattctt gcaagcatct gcgaggggga gcttagtcgt tcacattttg ctttcgcatc 789601 aatctgcaat agcaaagtct atgcgatttt tttacatcag caaagatttg ttcaattttt 789661 tccttttatg ccgagttttt ctgaaacaga taattgatgg tactcaacca ttttcttttg 789721 gtcaataaag taatgtttac ttattaatta aacacgcgaa aaagcaaacg aaaacataat 789781 taaattttat atatttatta aaagcttata tgtttattta cctttttttt gaattgtaat 789841 tgagaaaatc catatattgc ggacactaat aaaagaatac ctgctgaaac ataaactaaa 789901 cgaactccaa ggaaatctga aatagcccct atagccagaa ttgaaaacat aaaaatgaac 789961 tgtactaaag aagaccttgc agacattata ttaattcgag tttgctcggt tgttatgttc 790021 tgaataagtg tttcttgtgt aagatctctt aatatataag ccggccccat aaagagaacc 790081 aaaattagag ctaagtatga attacttata aaaccatata ttaaagttaa acttccatat 790141 gagacagcgc caattaacat aaaattaatt aacttatttt gaaatctctc cgacagctta 790201 tatattataa atccccctat catcgaacct aaataatatg ctccattaat aaatccccac 790261 catgattctc ctttatgcaa gacttcgtta acgaaagcta aagagacaga tcctatccaa 790321 atcattcctg cccatgactc aattaaatcc ataataataa ttgttctaag tttcttttgg 790381 ctaaataaat accgccaacc acttactata ctcttattgg gagaattttt ttcacgtatg 790441 acagaattag cgtggccatg tggtagacaa aataaaagag aaagaagaga tgtaaacaac 790501 aaaaagatag taagtataat ggtatatccc tcacctaaaa atgcaattat gagaccacct 790561 aaagaccagc ctacaaattg aaaagtttgg tccactgtag ataataatcc atttgctttt 790621 actcttctat caggagagat tatttcccct ataattgcac tttttaaagg tgagaaccat 790681 ccattaaaaa aggaaataca gctaataata ataaagacta aaatgagagt ttgattagag 790741 taagttctta ataaagcata gaacaaacat attaataaca gcatttgtat caattgagaa 790801 ataattattg taagaggcag ttttaatcga attgttatta acggtaatat agcacttcca 790861 aaaatacgaa aaataatact tattaatgtc accatagagg cgatggttgt cgaattggtc 790921 attttaaaca aaaacgaaat cactaccata gtatatagag aaaaacctaa atttgtagtg 790981 gtctggctaa ataaaataga ataataacct ttactcatat gtatcctccc ttggaataat 791041 ttttctcggt aaagagctta aacatattta aacaccttaa aacaacaaaa gtaaagaaaa 791101 aatttccttg taaactattt acttttattc tatttattgt tattgtttat ttaagttctc 791161 tgactattct atcaatattc agggaaccac atatcttatt aaagggggga aaaccatgag 791221 aaaattaaga aaaaactgga gaaaatcgat tgttagcccg gttctttata ctaatgaaaa 791281 atggtaaaca cttagggaat agcatttaat gctattcctt atttcaacaa acaaatcggg 791341 aggttatcgt aatttgactc tattaatgca agatcataaa tcaatttaca ataaagatat 791401 agaaatatta attgaagttg aagaacttat tacttctgtt ccagaaaata aaaaaaatga 791461 ttttaagagt ttaatcgata atagaattat gactctacta aataaaattc aacaccctgt 791521 agcagcggaa aatgtgtttg ggatgtgtat tgcttatccg aatacttaca taaggtatag 791581 attaattgat ttcgttgaaa aatgggtacc ttatttctct gctgtagaaa ctataatcaa 791641 tctaacccag gatccggatg atttagtttc ttttaaagct atggatgtct gtgcaaatca 791701 taaaattgaa gaatctgtag catatttgtc ttcgattatt gatgatgtcc gggagagtat 791761 aagctaccct aaaaaacctg tgggattagg ggcccaaaaa gtattaagta cattattaga 791821 tatattcggt gttgaaaaac atgaagagct agtaatgcta aaaaattatt ttgatcaaaa 791881 tggtatactt cctaataact ttgactttga agaaaaaatt cctcaaagtc taatagagga 791941 attcgaaaaa acagaagaag atgggatgat tttaattccg ggtggctttt ttgaattcgg 792001 tttaaatgaa aatgaaattc ctgacaaaac atttaattgg aaagatgctg ttcctagaca 792061 aaaagtatgg ttacctccat tttttatcga taagtatcct gttacaaata aagattatga 792121 tatctttacc gagttcatag aggaaaatgg gcatatattc tgtcatccta atgaaccgca 792181 gaataaacaa catagaagaa atacatattg ggatgatagg tatttagata atcatcccgt 792241 tacaggtata gatttttatg atgcatttgc ttacgcaaga tataagggga aagaattgcc 792301 aaccgagttt caatgggaaa aagctgctcg aggcgaaaag ggtaatgtct ggccttgggg 792361 agataaattt gatcctgcaa aggttcaata tgctggaagt ctttataatg aacccattac 792421 ttctttaaag tcctggagag aaaatttatt aaaagctcat gctgataaag aattaaatca 792481 tttaacaagt gatatttttg aacaaaatgg tgaaagtccc tatggagtat gcggtatgat 792541 cggcggaaca tgggagtgga ctagaagtga gcttaaaaca aagagagctt tccaccctat 792601 ttttgagaat gtaccattta atagtgttaa ctcatttgcc gttcttaaag gaggatcatt 792661 cttctctcat ccaggcttaa tgttcccttc ttttagagca aaagatattc ctttctgtcg 792721 acacaatgaa atggggatta gatgcgtaaa gaatattcca gtatataaaa ttagagaatc 792781 aattaatggg ccaattacta ataaagcaat ttattaatca ttctaggtta gagacttgat 792841 aaaagtatac taacattgtg tagtaatgtt cagcttgtag aaaaaacaat gttttttcta 792901 caagatttta ttttaaatgc ttttcaaaat tatcagggat tgagaatcag aaaaagagcc 792961 attaagctcg atcttagcta ggtattacga tcttctgtat attattgtga gaaatataga 793021 agattcagtt agttagcatt tcgattttaa gctgagcctg caatagcaaa gcatctgttt 793081 tgattattct ttttctgata cataagctaa ttttgtcgct tttctttttt gtcttttcac 793141 gcatttcgag gatgacttac tataattctt tcagcttttc tatgtgttaa gattcgaata 793201 gatgaaataa ctttaacaag ttggtcaata agaacagatt taactttatg ttaaaagagt 793261 atctcgtata gaacataaga agaatgacga gttttttaag attatcatca attatgtgag 793321 aataaaatat tataagggaa aatgaaggct gtcacgtttc tcgacagccc tagggaattc 793381 ctctcctttt catttcgccc gtaatttcgg gcacagtccc gtcggcaggc acattggctt 793441 ctggtcgatc gggcttctca tgatgcagca ttccaagccg aagacttcac ggaaaaatgg 793501 ctgggtgaac acatcttccg gtgttccggc gttgtatatt tttccgtcca gcacactgat 793561 cagatagtca gcatattgag cggcttggtt taaatcatgg agcaccatga caacggtgcg 793621 gccatggtcg cggttcagct ttttcagcag ttcaagcact tcaatctgat gtgagatgtc 793681 taaatacgtg gtcggctcat caagcaaaag caaatcagtg ccttgcgcaa gtgccatgga 793741 aatccaggct ctttgtcttt ggccgcctga gagggcatca agtgtccgat ccttcagttc 793801 aatcatgccc gttgcttcca gcgcccactc taccatgtca tgatcctctt gggtatgctt 793861 ggataacagc tttttgtgag gatgtctgcc aaaatagcat aattcctcta ccgtcaatcc 793921 ttcaggagcc tgaggagatt gtggaagaat ggccagtttt tttgcgactt cttttgatgg 793981 ctggcggtgg atgtcttttc cttctagtag cactgtaccg ctttttgggg ccatcagcct 794041 ggcgagcgat ttgaggattg ttgatttacc gcagccatta gcgccgatga gcgcagtgat 794101 ttttccttct tctatcttta agtcgactcc gtcaataatc actgtactgt catatgaaag 794161 agtgagctgg tctgcagcca gttttcccat ggtatcctct ccctactgtt tcctcgcttc 794221 gaatttcaat aaatataaga aataaggcgc gccgatcacg gctgtcagta ttccggcagg 794281 tatttcaacc ggaggcatga tgccgcgccc taacgtatct gcaattaata atataatagc 794341 accaatcaat gccgatgcag gcagtaaata tttagctttt tctccggtaa gccgtctggc 794401 gatatgcgga gcaagcaagc cgataaaacc gattgagccg acgacggcta cacagcttcc 794461 cgccagcgcc accgcggtga aaatcaggat gaatctcagc cggtttgcgt tttctccgag 794521 accctgtgca agctcatccc cgagtgacat aagatccagc ttcggtatga gtatgcagac 794581 gatcggaaaa agaatcaaaa gccatggcgc aagcagcttg acttcttccc agtttcttcc 794641 ccagaggctt cctgtcagcc aaatgagtgc agcattcacg tcgcctggaa acttgaccat 794701 catatattgc attccggcgt ggcagaccgc gcctaaagca atgcctgata aagccagtga 794761 agagggctga atgctctttt ttcgggctat cattaataat agtacagcaa taatggcggc 794821 tccggcaaat gcggagaacg gaagcacgta taccggcgac tcaggaaaga tgagaatcac 794881 agccatcgcc gcaagtccgg agccttttga aatgccgaca acgtccgggg aagcgagcgg 794941 atttcggatc acaccctgta aaatcgctcc ggcagcggca agtccagcac ctgccaaaat 795001 cgctaatata atgcggggaa ggcgatattg ctggatgata aattcaaagg aatgatccag 795061 tcccagcaga ttcgtcacta ccgcatcagg tgaaatgtat aatgcaccga ttccaatgct 795121 gatgacggac agaacgatta aaatcacggc caatatgagt atcgccagta aggggcgttt 795181 ttgttttctg gttgttttct tcatttcagg tttcgccctt tccttgccaa atataagaaa 795241 aacggcgttc cgataatcgc ggtgacaatg ccgaccggtg attcataagg aaatgcaatc 795301 catctggcca gaacatctgc gtacaccagc aaaatggcac cgaacagtgc cgaaaacgga 795361 agcacgtatt gataatgttc tccgatcagc ttgcggacaa tatgcgggac gagcagcccg 795421 acaaagccaa tcggcccggc gacggctacg gaagcgccgg aaagaattaa aataatcaaa 795481 ctgatcagaa tcctgatgcc gttcatattt tgtccaagcc cttttgctgt ttcgtctccg 795541 agaccgagaa cagaaacaga accggaaaat acgagggcaa gcccgatgcc aatgacagaa 795601 aaaggagcga tggttatgac gtcctgccag ttgctgccgt cgattgcgcc tgtcatccag 795661 tacagaacat cctcacctga ctcatttaaa ataatgatgg cctgtgtcat agaggagagg 795721 aacaagtgca cggccattcc tgacagcgcc agcttgacag gcgtcattcc gccggatgag 795781 gcaatcatat acacaatcgc gccgcctgct gccgcacccg caaaagcgaa tataacagat 795841 gaatagggcg atgccggcag aatgacgaga gaagcaacaa caaaaagcga tgcacccgca 795901 ttcacaccga aaatttgggg tgaagccaga ggatttctgg tcatagcctg catcagcgcc 795961 cctgctacag ctaggctggc gccgacaaaa acgccgatta atgtgcgggg aaggcgaaga 796021 gtagagatga tgagctgttc ctttgaaccg tcccatacaa aaagatattt caatgaatct 796081 atgatgctga tgtctgaggc tcctactgaa agattcagcc caagcccaaa tataaaaata 796141 atcagtgcaa tgataaacat catcagtctt gatgatgagc gccgtttggc tgaatgatac 796201 aacagtctca cttccttact gcgtctggtt gcaaaaacga agaagcaagg attcccctcg 796261 cttctcattt gtcctattta ttatacactt ttttaagcac atctttggcg cttgtttcac 796321 tagacttgat gcctctgaat cttgtccaag tgtcacggtc cgcatcatag acttgtccat 796381 ttttcaccgc tttgagattt ttccagagcg ggttcgtttt ccactcatct acaatggttt 796441 tgccttcgtt ggctgagatg aacaaaatat caggatcgat tttgctcaat tgctcaaggc 796501 tgacctcttg ataggcgtta tctgacttca cagcgtgtgt aaagcctagc attttaaaga 796561 tttctccgtc ataggatgat gatgtatgaa gctggaagga atccgctctt gcaacgccga 796621 gaacgatgtt gcggttttca tctttcggaa gttcggcttt tagatcgttg atgacttttt 796681 tgtgctcggc aagcttttct tttccttcat cttctttatt taatgcttta gcaatggtcg 796741 taaagctgtc gatcgtttcg tcatatgtcg cttcacggct ttttaattca atcgtcgggg 796801 cgattttttt cagctgttta taaatgtttt tatggcgctc agcgtcagcg atgattaaat 796861 caggcttcaa ggaactgatg acctcaagat tgggttcgct gcgtgtgcct acagatgtgt 796921 aatcaatgga gctgccgaca agctttttaa tcatatcttt tttgttgtca tctgcgatgc 796981 ccaccggcgt aatgccgaga ttgtgaacgg catccaagaa tgaaagctca agcacaacca 797041 cccgcttagg tgtgccgctt actgtcgttt ttccttcttc gtcatggatc actctggaat 797101 ccttagactc gcttttgccg cttccgttgt tattctggct tgatgaacag ccggatacaa 797161 tgaggcaggc gagcaataaa acactcatga tggcaatcaa cttgttagaa taggtgcgca 797221 tgtcattctt ccttttttca gatttagtaa tgagaatcat tatcacatgt aacactataa 797281 tagcatggct tatcatgtca atattttttt agtaaagaaa gctgcgtttt tactgctttc 797341 tcatgaaagc atcatcagac acaaataagt ggtatgcagc gttaccgtgt cttcgagaca 797401 aaaacgcatg ggcgttggct ttagaggttt cgaacatatc agcagtgaca taaggaagga 797461 gagtgctgag ataaccggac aatttctttt ctatttcatc tgttagtgca aattcaatgt 797521 cgccgatatt catgataatc gagaaaacaa agtcgatatc gatatgaaaa tgttcctcgg 797581 caaaaaccgc aagctcgtga attcctggtg aacatccggc acgcttatgg aaaatctgtt 797641 tgactaaatc actcacaatc caagcattgt attgctgttc tggtgaaaag tattgcatta 797701 gacatacctc ctgctcgtac ggataaaggc agcgtttcat ggtcgtgtgc tccgtgcagc 797761 ggcttctcct taattttgat ttttctgaaa ataggtcccg ttcctatcac tttaccatgg 797821 acggaaaaca aatagctact accattcctc ctgtttttct cttcaatgtt ctggaatctg 797881 tttcaggtac agacgatcgg gtatgaaaga aatatagaaa acatgaagga ggaatatcga 797941 catgaaacca gttgtaaaag agtatacaaa tgacgaacag ctcatgaaag atgtagagga 798001 attgcagaaa atgggtgttg cgaaagagga tgtatacgtc ttagctcacg acgatgacag 798061 aacggaacgc ctggctgaca acacgaacgc caacacgatc ggagccaaag aaacaggttt 798121 caagcacgcg gtgggaaata tcttcaataa aaaaggagac gagctccgca ataaaattca 798181 cgaaatcggt ttttctgaag atgaagccgc tcaatttgaa aaacgcttag atgaaggaaa 798241 agtgcttctc tttgtgacag ataacgaaaa agtgaaagct tgggcataaa gcaaggaaaa 798301 aaccaaaagg ccaatgtcgg ccttttggtt tttttgcggt ctttgcggtg ggattttgca 798361 gaatgccgca ataggatagc ggaacatttt cggttctgaa tgtccctcaa tttgctatta 798421 tatttttgtg ataaattgga ataaaatctc acaaaataga aaatgggggt acatagtgga 798481 tgaaaaaagt gatgttagct acggctttgt ttttaggatt gactccagct ggcgcgaacg 798541 cagctgattt aggccaccag acgttgggat ccaatgatgg ctggggcgcg tactcgaccg 798601 gcacgacagg cggatcaaaa gcatcctcct caaatgtgta taccgtcagc aacagaaacc 798661 agcttgtctc ggcattaggg aaggaaacga acacaacgcc aaaaatcatt tatatcaagg 798721 gaacgattga catgaacgtg gatgacaatc tgaagccgct tggcctaaat gactataaag 798781 atccggagta tgatttggac aaatatttga aagcctatga tcctagcaca tggggcaaaa 798841 aagagccgtc gggaacacaa gaagaagcga gagcacgctc tcagaaaaac caaaaagcac 798901 gggtcatggt ggatatccct gcaaacacga cgatcgtcgg ttcagggact aacgctaaag 798961 tcgtgggagg aaacttccaa atcaagagtg ataacgtcat tattcgcaac attgaattcc 799021 aggatgccta tgactatttt ccgcaatggg atccgactga cggaagctca gggaactgga 799081 actcacaata cgacaacatc acgataaacg gcggcacaca catctggatt gatcactgta 799141 catttaatga cggttcgcgt ccggacagca catcaccgaa atattatgga agaaaatatc 799201 agcaccatga cggccaaacg gatgcttcca acggtgctaa ctatatcacg atgtcctaca 799261 actattatca cgatcatgat aaaagctcca ttttcggatc aagtgacagc aaaacctccg 799321 atgacggcaa attaaaaatt acgctgcatc ataaccgcta taaaaatatt gtccagcgcg 799381 cgccgagagt ccgcttcggg caagtgcacg tatacaacaa ctattatgaa ggaagcacaa 799441 gctcttcaag ttatcctttt agctatgcat ggggaatcgg aaagtcatct aaaatctatg 799501 cccaaaacaa tgtcattgac gtaccgggac tgtcagctgc taaaacgatc agcgtattca 799561 gcgggggaac ggctttatat gactccggca cgttgctgaa cggcacacag atcaacgcat 799621 cggctgcaaa cgggctgagc tcttctgtcg gctggacgcc gtctctgcat ggatcgattg 799681 atgcttctgc taatgtgaaa tcaaatgtta taaatcaagc gggtgcgggt aaattaaatt 799741 aagaaagtga aaaacacaaa gggtgctaac ctttgtgttt tttaattaat taaaatgttt 799801 attaacttag ttaaggagta gaatggaaaa ggggatcgga aaacaagtat ataggaggag 799861 acctatttat ggcttcagaa aaagacgcag gaaaacagtc agcagtaaag cttgttccat 799921 tgcttattac tgtcgctgtg ggactaatca tctggtttat tcccgctccg tccggacttg 799981 aacctaaagc ttggcatttg tttgcgattt ttgtcgcaac aattatcggc tttatctcca 800041 agcccttgcc aatgggtgca attgcaattt ttgcattggc ggttactgca ctaactggaa 800101 cactatcaat tgaggataca ttaagcggat tcgggaataa gaccatttgg cttatcgtta 800161 tcgcattctt tatttcccgg ggatttatca aaaccggtct cggtgcgaga atttcgtatg 800221 tattcgttca gaaattcgga aaaaaaaccc ttggactttc ttattcactg ctattcagtg 800281 atttaatact ttcacctgct attccaagta atacggcgcg tgcaggaggc attatatttc 800341 ctattatcag atcattatcc gaaacattcg gatcaagccc ggcaaatgga acagagagaa 800401 aaatcggtgc attcttatta aaaaccggtt ttcaggggaa tctgatcaca tctgctatgt 800461 tcctgacagc gatggcggcg aacccgctga ttgccaagct ggcccatgat gtcgcagggg 800521 tggacttaac atggacaagc tgggcaattg ccgcgattgt accgggactt gtaagcttaa 800581 tcatcacgcc gcttgtgatt tacaaactgt atccgccgga aatcaaagaa acaccggatg 800641 cggcgaaaat cgcaacagaa aaactgaaag aaatgggacc gttcaaaaaa tcggagcttt 800701 ccatggttat cgtgtttctt ttggtgcttg tgctgtggat ttttggcggc agcttcaaca 800761 tcgacgctac cacaaccgca ttgatcggtt tggccgttct cttattatca caagttctga 800821 cttgggatga tatcaagaaa gaacagggcg cttgggatac gctcacttgg tttgcggcgc 800881 ttgtcatgct cgccaacttc ttgaatgaat taggcatggt gtcttggttc agtaatgcca 800941 tgaaatcatc cgtatcaggg ttctcttgga ttgtggcatt catcatttta attgttgtgt 801001 attattactc tcactatttc tttgcaagtg cgacagccca catcagtgcg atgtattcag 801061 catttttggc tgtcgtcgtg gcagcgggcg caccgccgct tttagcagcg ctgagcctcg 801121 cgttcatcag caacctgttc gggtcaacga ctcactacgg ttctggagcg gctccggtct 801181 tcttcggagc aggctacatc ccgcaaggca aatggtggtc catcggattt atcctgtcga 801241 ttgttcatat catcgtatgg cttgtgatcg gcggattatg gtggaaagta ctaggaatat 801301 ggtagaaaga aaaaggcaga cgcggtctgc ctttttttat tttcactcct tcgtaagaaa 801361 atggattttg aaaaatgaga aaattccctg tgaaaaatgg tatgatctag gtagaaagga 801421 cggctggtgc tgtggtgaaa aagcggttcc atttttccct gcaaacaaaa ataatggggc 801481 tgattgcggc tctgctggtc tttgtcattg gtgtgctgac cattacgtta gccgttcagc 801541 atacacaggg agaacggaga caggcagagc agctggcggt tcaaacggcg agaaccattt 801601 cctatatgcc gccggttaaa gagctcattg agagaaaaga cggacatgcg gctcagacgc 801661 aagaggtcat tgaacaaatg aaagaacaga ctggtgcgtt tgccatttat gttttgaacg 801721 aaaaaggaga cattcgcagc gcctctggaa aaagcggatt aaagaaactg gagcgcagca 801781 gagaaatttt gtttggcggt tcgcatgttt ctgaaacaaa agcggatgga cgaagagtga 801841 tcagagggag cgcgccgatt ataaaagaac agaagggata cagccaagtg atcggcagcg 801901 tgtctgttga ttttctgcaa acggagacag agcaaagcat caaaaagcat ttgagaaatt 801961 tgagtgtgat tgctgtgctt gtactgctgc tcggatttat tggcgccgcc gtgctggcga 802021 aaagcatcag aaaggatacg ctcgggcttg aaccgcatga gatcgcggct ctatatcgtg 802081 agaggaacgc aatgcttttc gcgattcgag aagggattat tgccaccaat cgtgaaggcg 802141 tcgtcaccat gatgaacgta tcggcggccg agatgctgaa gctgcccgag cctgtgatcc 802201 atcttcctat agatgacgtc atgccgggag cagggctgat gtctgtgctt gaaaaaggag 802261 aaatgctgcc gaaccaggaa gtaagcgtca acgatcaagt gtttattatc aatacgaaag 802321 tgatgaatca aggcgggcag gcgtatggga ttgtcgtcag cttcagggag aaaacagagc 802381 tgaagaagct gatcgacaca ttgacagagg ttcgcaaata ttcagaggat ctcagggcgc 802441 agactcatga attttcaaat aagctttatg cgattttagg gctgcttgag cttggggagt 802501 atgatgaagc cattgatctg attaaagagg aatatgcgat acaaaatgaa cagcatgatc 802561 ttttattcca taacatccat tcgcagcagg tgcaggccat tttgttaggg aaaataagca 802621 aggcatcgga aaagaaggtc aagctggtga ttgatgagaa cagctcactc gcgcctcttc 802681 ctgcgcatat cggcttgtcc catcttatta cgattattgg caatttaatt gataacgctt 802741 tcgaagctgt agcggagcaa agcgtgaagg aagttttgtt ttttatcacg gatatgggcc 802801 atgacattgt cattgaagta tcagacacag ggcccggtgt gccgccagag aaaatagaag 802861 ctgtgtttga gagaggctat tcttcaaagg ggatgaggag aggctacggt ctggccaatg 802921 tgaaagactc agtgcgtgaa ctgggcggct ggatcgaact ggcgaatcaa aaaactggcg 802981 gggcggtatt cactgtattt ataccgaagg agaaacaaag ggggaatcca tttgattcac 803041 atcgcgattg cggaggatga ttttcgagtt gcgcaaatcc atgagagatt gattaaacag 803101 cttgatggat tcaagattat cggcaaggcg gctaacgcaa aagagacatt ggcgcttttg 803161 aaggaacaca aggctgattt gcttctgctg gatatttata tgccggacga gcttgggacc 803221 gcgttgattc ctgatatacg aagccgattt cctgaagtgg acattatgat tatcacagcg 803281 gcaacagaaa cccgtcattt gcaggaagcg ctaagggcgg gaattgccca ctatttgatc 803341 aaacccgtaa cagctgacaa gttcaggcag gtgctgcttc agtataaaga aaaaaggaag 803401 ctgctcatgt ctcagccgga ggtcagccaa tccatgatcg accatatttt tgggaacggt 803461 gtgaagacag ctttgccggc agaggatttg ccgactggca ttaattcgat tacactgcga 803521 aaaattaagg aagcgcttca gactgcgtca gaaggattga cagcggagga acttggggaa 803581 aaaatggggg cgtcacgaac aactgcccgc cgttatgccg agtaccttgt gtcaaaggaa 803641 gaagcaagag ccgagcttga atacgggatt atcggcaggc cggagagaaa atattatttg 803701 gcggcggatt agatatgaaa aaatctataa tcctattgaa tattctattg atctttatgc 803761 agggtgatat caggcaggcg gctgcgccgc gcctgccgga cgggccgata gaaattgtcg 803821 tccctgccga accttctggc ggctgggatg tcacagcgca ggcgatccaa tcagttttga 803881 ggcagaagca gatcgtgaag gatgatgttc atatcgtcta taaatccggc ggcgggggag 803941 agaaaggctg gaaatatgtc aacaaaagca gcaaacaaac catcagcatg acgtccagcc 804001 taatattgag caatgatctt ctcgggcaaa gcaaattaaa aatgtccgat tttacgccgc 804061 tcgccattct ctccaaggaa tggcagacgg ttgcattgcc aaaaggatca gcgttaacaa 804121 atggcaagga tgtgctgaat gagatcaaca tgcatcccgg caaggtgaga atcggctttg 804181 ccccggggtt tggcaatgat gatcagctct cgttcgtcag agcggcagat atgtacggca 804241 ttgacccgtt tgacattcaa ttctcacagt atgacagcag cgaacagctc attcaggcgc 804301 tgatcagaca tgagatagaa gcggcttcca tgacactttc tgaagcgaaa ccatatgaac 804361 gaaacggcga tatcacgtta gccgctgtaa cgtctgataa aagacttccc ggttttccaa 804421 atgtaccgac gtggaaggag cagggaatcc cgtttgtttt ttctcattgg agagggattt 804481 tgggcccgaa aaatatgtct gaggaagaga tttcttactg ggatcaagcg ctaaagaagg 804541 tcacctcctc acctgaatgg aagcggaaaa taaacgaaca ggactgggaa agcttttatt 804601 taaacagcag ggaaacgaaa cggtttttag aagagcaatc tgctttttat caaagcatca 804661 tgacaggaaa ttaaaatccc gacatcccgg gatttttttc atgccgaaaa ttgatcaaaa 804721 agaacaaaac ggttttaaaa aattaaaaat acaaaaaaac caaattattt acttgcggtt 804781 ggttttccca tacgatggca aaaaggcaag acaaaaaggg gagtaaggga gaaaaaaatg 804841 taagcggatt catttaaggg ggaatggatg tgttagcaat cttaggcttt ctcatgatgc 804901 ttgtgtttat ggcattgatc atgacaaaac ggctttctgt tttaacagca ttagttttga 804961 cgccgattgt gtttgcgctt atcgccggat ttggatttac tgaagttggg gacatgatga 805021 tttcggggat tcagcaagtc gcgccgactg cggtcatgat tatgtttgcg atcttatatt 805081 ttggaattat gattgataca ggcctgtttg atccaatggt tggcaaaatt ttaagcatgg 805141 tcaaaggaga ccctttaaaa attgttgtcg ggacagcggt tcttacaatg ctcgtcgcct 805201 tggacggaga tggctcgaca acgtacatga ttacgacaag cgccatgctt ccgctctatt 805261 tgctgctagg catccggcca attatcttgg caggaatcgc gggagtcggc atgggaatca 805321 tgaacacgat tccatgggga ggtgcgacgc cgagggcggc gagtgcgctg ggggttgatc 805381 cagctgagct tacagggccg atgattcctg tcattgcaag cgggatgctt tgtatggtgg 805441 cagttgcgta tgtgcttgga aaagcggaac gaaagcgcct tggtgtgatt gaactgaaac 805501 agccagccaa tgccaatgaa ccggctgctg cggttgaaga tgagtggaag cggccgaagc 805561 tttggtggtt caatttattg ttaacgcttt ctttaatagg atgtttagta tcgggtaaag 805621 tcagtttaac cgtactgttt gtcattgcgt tttgtattgc gctgattgtg aattatccca 805681 atctcgagca tcagagacag cgcatcgcgg cgcattccag caacgtgctg gctatcggtt 805741 caatgatttt tgctgcgggg gtgttcacgg ggattttgac aggcacgaaa atggttgatg 805801 aaatggcgat ctcgctcgtg tccatgatac cggaacaaat gggcggattg atcccggcga 805861 ttgttgcctt aacaagcggc attttcacat ttttgatgcc gaatgacgcg tatttctacg 805921 gggtgctgcc gattttatca gaaacagctg tcgcatacgg tgtggataaa gtggaaattg 805981 ccagagcctc tattatcggc cagccgattc atatgctgag tccgcttgtg ccatccactc 806041 atttgcttgt cggactcgtc ggagtttcta ttgatgacca tcaaaaattc gcattgaaat 806101 gggcggttct cgcagtgatc gtcatgacgg ctatcgctct attgatcggt gcgatctcta 806161 tttccgtatg ataattcagg cgtaatgaca cacactaacg gcatacaaca ttccggaggt 806221 gtcattatga gtgatcctta tatgccgctg acttcagtca gaagcggagc ggggttcgaa 806281 gcggcaaaag gggtgcacgg cctgactgtg caaattgcga atgtctattt tattcagctg 806341 ccttctgaac ctcactcatt tgttttaatt gatgccggca tgccccaatc agccggcgtg 806401 attgtcaatg aagccaaaca aagattcggt gaagggtttc agctgaaggc gattatcctc 806461 acacacgggc actttgacca tattggggca atcgaagaga tccttgagca ttgggatgtg 806521 cctgtttata tccattctcg ggaaatgcct tatgtaacag gtaaagagga ttatcctccg 806581 gctcgtcctg acagcaagag cgggctggtc gctaagctgt cgccgctgtt tccgcggcac 806641 tctatcgata tttcctcaca tgtccaggca ctgccggaag acggttcagt tccttttctt 806701 gacgagtgga tgtggatcgc gacaccagga cacacgccgg gccatatttc gttattccgc 806761 gatgacggcc gcgtgcttgt ggcaggtgat gctgttatta cagtggaaca ggagaaaatg 806821 gctgacgtct tgatacaaaa acaggagctt cacgggccgc cggcttattt cacgcctgac 806881 acagagacgg ccgctgagtc cattctaaag ctggccggtc ttgaaccgga agcgttattg 806941 accgggcacg gcataccgat gaccggcaaa aactttcgaa gtgacttaac tgaattggca 807001 aatcggttat cgtctatttg acacccgcac cacgcgggtg ttttttattg ttttccagga 807061 agttgcagaa aaatcatttg tcttgccgct taaaaacgat acaatgaaaa gcatgaagtg 807121 atgtgaaggg gagagtttgt tggaagaaaa agaaatactc tggaacgaag cgaaagcgtt 807181 tattgccgca tgctatcagg aattgggaaa ggaggaggaa gtgaaagacc gtctcgcgga 807241 cattaaaagt gaaattgacc tgaccggaag ctatgtacat acgaaggaag agctggagca 807301 cggagcgaaa atggcttgga gaaacagcaa ccgctgcatc ggcagattgt tctggaattc 807361 gctgaatgtt atcgacagac gagacgtccg gacgaaggag gaagtgcgtg atgccctctt 807421 tcaccatatt gaaaccgcca ccaataacgg gaaaatcaga ccgaccatta cgattttccc 807481 tccggaagag aagggtgaaa agcaagtcga gatctggaat catcagctga tccggtacgc 807541 tggatatgag tcagacggag aaagaatcgg cgacccggct tcctgttccc tgacagcagc 807601 ctgcgaagag ctcggctggc gcggagagcg aacggatttt gacctgctgc cgctcatttt 807661 tcgcatgaaa ggggacgagc agcctgtctg gtatgagctg ccgcgttcac ttgtgattga 807721 ggttccaatc acacatccgg acatcgaggc gttttctgat ttggagctga agtggtacgg 807781 cgtgcctatt atttctgata tgaagcttga ggtcgggggc attcattata atgccgcgcc 807841 atttaacggc tggtatatgg gcacggagat cggagcgaga aacctcgcag atgaaaagcg 807901 gtacgacaag ctcaaaaaag tagcgtccgt gatcggcatc gccgctgatt acaatacgga 807961 tttatggaag gatcaagcgc tagttgaatt gaataaagct gtgctgcact cgtataaaaa 808021 gcagggtgtc agcatcgttg accatcatac agcggcaagc cagtttaaac ggtttgaaga 808081 acaggaggaa gaagcgggca gaaagctgac gggggactgg acgtggctga ttccgccaat 808141 ttcacccgct gccactcata tcttccaccg ctcctatgat aactcaatcg ttaagccgaa 808201 ctatttttat caagataagc cttatgagta aacaatagaa aatcgatgat ggccttcaag 808261 gctgcgggat tcagtcacag agatgtcggt aacctttgag aaagggcttc cgttctttac 808321 agcctcaaca aacgattgca gggcgttttc cggaccctct gccaaaatct cgacacgccc 808381 gtcatcacgg tttttgaccc agccggccag ttttcgctta tcagcttcca tttgaacaaa 808441 atagcgaaag cccacacctt gaacccggcc gtctacaatg attcggtatt gaagcatgta 808501 aaaaccacct tttcttttta tgataatcaa tcattttaca acctgtaaag gggatgtgtt 808561 tgtatgaaac aagagcgcta ttcagttctt tctcttaatc tgggaaaacc gcagacgctt 808621 gaatatgacg gaaagaaaat cgaaaccggc atcatgaagc ggccggctaa atcagccgtc 808681 atgctgtatc gggagaattt tgaaggagac ggacaggcgg acctcgtcaa ccacggcgga 808741 cctgataagg ctgtctgtgt ctacccggcg gagcattatc cgttttggga agagttcctc 808801 tcaagaccgc tgtcaaatgc cgcatttgga gaaaatctga cggtcgcggg cctgactgag 808861 gagaatgttt gcatcgggga tgtgttcaga cttgatgaag ctgttgttca ggtcagccag 808921 ccgcgccagc cgtgtgtaaa gctggcgaaa aagtttggtg taaaagaaat ggtgctgaag 808981 gtccagcaaa ccggctatac agggttttat tttcgcgtgc tggaggaggg cagggtgtct 809041 cccggcgcga accttgaatt gctgtccaga ggagagaaag gcatatccgt ccagttcgcg 809101 aaccgcatca actaccatga tgcaaaaaat ctcaccgcca ttgaacggat tttaagtgag 809161 gctgcactat cggaaagctg gagagcgtcc tttatgaaaa aaaaggacag gctgctgccg 809221 gttgaataga aaaaagccgc gcatatcaac gtgcgcggct ttgccatatt taagattgtt 809281 ttttctttga ttcaagcagg ttggcaagaa aataggtttt atagctttga agctttcttc 809341 cttcatggtg cgtgatcccc tgctttttta gttctgccac ataccagcct ttactgccgt 809401 aatgcatgtc agaaaactcc tttccctatc tgatttcgaa acgattggca ttgtaacatc 809461 tataaaaaga tgctgaaaag agatgcgggg aaaactgagc ctttcgcact agatgtacga 809521 atgttcttct gaatgtatat gcggagcaaa agccgaatat gatttaatgg ccggttagtt 809581 tgatcatgac aacgccaaat gtcataatgg cgaaaacaat gccgatatat gtgagcatcc 809641 cgtttttttt cttaacgccg taaacggtca taatgatgcc ttcaatgaaa aaaatgatgc 809701 cgaaaataat aaaccacatg cagataaagg ctcctttcac agacataata gtagtgtagc 809761 atatctgaaa gagccgggct gtgacaatat caagaaagcc gggcgcatat cgcccggctc 809821 atgttttatt gtttatcaac caatttgacc agaagctgtg ccaaatgttc tttctcatct 809881 tcgtctgcaa cgctccaaag ctcttgcagc agcatttctt caccgttttg cggctcttca 809941 tgctttgcga ggtagtctcc caggatcgca gcgcttttta caagcttgcc gtcatccaat 810001 cccagctttt tgcctcggtt gacttgtttt ttcaggtagc ctttaaattc ctcaaagtct 810061 tttaaaatgt cttcttttat tgtgccatgc atcgcgttca tttcgttttc aatttggatt 810121 ttttcttgat ctctgttcat tgcaagacct cctcgtacag aataatgatg ctttacctgc 810181 aattggagga ggttaaacct gccggaagcc cggaatgtgt tttacagttt cgtcaggata 810241 atcggttcat cttttgtgat gacgatcgtg tgttcaactt gggcaaccat gcttttatcc 810301 ggcgtcttga acgtccagcc gtctccagct tcaacaatcg tttctgcttt cgttgaaata 810361 aacggttcaa gcgcgatgac tgtgccattt ttgaacagcg cattatcaaa cggatcataa 810421 tagttcatga tgtggttcgg cgcttcatgc aggcttcggc cgattccgtg gccggtcagg 810481 gttttgatga cggtaaagcc ttgagagcgt gcttcatgat aaacggctct tccgatctgg 810541 ttttggcgct tgcccgcttt tgcctgctga agcccctttt gaaaagcgtt ttccgcgcat 810601 tggcaaagct tatgaaggcg ttcttctcct tcaccgagca caaatgagat gcctgtgtcg 810661 gaatagaagc cgccaaattc agcggagatg tcgatgttga caaggtcccc tgcttttaaa 810721 attttggatg tgcttggtat gccgtgagcc acttcatcat ttacgctgat acatgtcaca 810781 cctggaaaat cgtattcctt ctcaggagct gaaacggcgc cgtgctcatc aagcacagct 810841 tttccgataa ggtcaaggtc ttttgtgctc atgccgggct ctgccttccg cttcatttct 810901 tcacgcgcaa gcgcgacgat tcttccgatt tttttcaggc cttctaattc ttgatcgttt 810961 gttacaatca tctgtcattc ccgctttctt tttaaataat ctagattaag cttaccacaa 811021 ctgtcttaaa aataggaaac acacggacct gggaaaaaag aaataccccc gggaaaattg 811081 gtatagatca ctagatatct tatatggtat atttgaaaaa aaagggtatg agggggatgg 811141 gtatgctttc atttttacaa aaactcggga agtcatttat gctcccgatt gcggttctgc 811201 ctgcggttgg aattatcctt gcgcttggca gagaggatgt atttaatatc ccgtttgtct 811261 atcaggcggg gacggcggtt tttgatcatc tgccgcttat ttttgcgatc ggtattgcca 811321 tcggcatttc aaaagacagc aatggggcag cgggtttatc aggggcgata tcgtatctga 811381 tgcttgacgc ggcaacaaag acaattgata aaacaaataa catggcggtg tttgggggaa 811441 ttattgccgg tttaattgcc ggttacacct ataaccgctt caaggatacc aagctgcctg 811501 aatatctcgg gttcttcagt ggcagacggc ttgtgccgat tttaacagcc attattacga 811561 tcattttagc gggcatattc ggagtggtct ggccgccgat tcaatcgtgt atcaactcgt 811621 ttggagagtg gatgctcggg ctcggcggca tcggggcagg catattcggc ctattcaaca 811681 ggctgttaat tccgcttggc cttcaccatg tgctgaacaa tattttctgg ttccaattcg 811741 gagaatataa cggagtgaca ggggatttgg cgcgcttttt cgcgaaagat ccgactgcgg 811801 gcacatatat gaccggattt ttcccaatca tgatgttcgg tcttccggcg gcgtgtctgg 811861 ctatggttgt gactgcgaag ccgtctaaac ggaaagcgac ggctggaatg atgattggat 811921 ttgctttaac ggcgtttatc acagggatta cggagccgat tgagtttgca tttatgtttt 811981 tatctccgct tttatacgct gttcacgcgg tcttaaccgg gttatcttta tttatcgtca 812041 actggctcgg catccgctca ggcttctctt tttcagccgg agctatcgat tatgtgctca 812101 gctatggaat cgcggaaaaa ccgctgcttc tgcttttggt aggtatatgc tatgcggcag 812161 tatactttat cgtgttttat gtactgatta aggctttgaa tttaaaaacg cctggacggg 812221 aagacgatga tgtggatgaa gtgctggatg aaaatactgt tcaggatgta aatgaaaaca 812281 tcatgctgaa agggctcggc ggaaaagaaa accttcaaac cattgatcat tgcgccacaa 812341 ggctgcgact gactgtgaag gataccgctt tggtggatga agcactgcta aagaaagcag 812401 gcgcaaaagg ggttgtcaaa tcgggcgggc aatcggttca agtcattatt ggcccgaatg 812461 tggaatttgc agctgaggaa ttgagggctg ctgtcaaata aaaaagcgga gagggcaacc 812521 tctccgcttt ttcttattta tcttcgttat cctttgacgt ttcggaagaa tcttcgtcat 812581 gttttgtgta atcataatca gaaggattca ccttcttaaa acctttcggc tcgtagaacc 812641 gcagcaggtc tccgtttatg attttatcgg acatttcaag ttccttcttg acgagtgagt 812701 cttctgactt gtcgacttcg gattcatcga gttcttttcc ggttttcgtg tcgtaatact 812761 taccggatat tttcgtgtac ttcggtgaaa taaagtctcc gtttcggaac ggaatcactt 812821 cacggtgttc tttcgataaa atatcagaac cggacatcag atagtccttc gtatccactc 812881 cgagcagatg cagaatggta ggagccacat caacgtctcc ggcatattta tgaactttct 812941 cgcccttcac gccggcagcg tggataaaga gcggcacccg ttgaagctgg gcgttgtcgt 813001 aatcagtgat ttcatccttg ccaagcactt tcgccatcgc tttattgtgg ttttcagaga 813061 tgccgtagtg gtctccgtac atcacaataa tcgatttatc atataacccg tcttttttca 813121 gatcattgaa gaattgttca atggactgat caaggtaatg ggctgactgg aaatagttat 813181 cgacgacaga gtcaccaaag tctccagccg ggaagtctgt atccccctca tccattccga 813241 atgggaagtg gttggaaagg gtaatgaact tcgtatagaa cggctgcggc aggctttcca 813301 gcagcggcat tgattctttg aagaacggtt tgtctttcat gccgtagttt ttcgtgtttt 813361 cttcgttcat gtcatagtaa gcagaatcaa agaatttatc aatgccttcc gccttgtaca 813421 tttcgttacg gttccagaac gtctgcgtgt tcccgtggaa agtagcagat gtgtaattct 813481 tagacttcag aatcgccgga acggattgca gcgtgttttg cgctttgttt acgaaaactg 813541 aaccttgagc cagcgggtac agagagtttt ccatcataaa ttcagcatca gatgttttac 813601 cttgtcccgt ttggtggaaa aagttatcaa agtagaacgt ttcgttatca tgtgccagtt 813661 tatttaagaa tggtgtcact tctttgccgt caattttata gtcgatgata aatgactgca 813721 aagattcaag tgaaacgtaa atgacgtttt ttccttccgc tttgccgaaa tacacgttat 813781 tcggcacatc gtaattggct ttcatgtagt tttctacttc cgttacgtcg ctggaatcgg 813841 caagcgcgcg ctggctgttg gacttgatat tctgtacagc gtcataaatc gtgaaattgt 813901 atgttcccaa gtatttcaca agatagttcc ggtcgaatga tcttgtcagc aattcaggac 813961 ggtctgattc cgcaactgcc aggttgatca agaacacaag aattgaagac gcaaaaataa 814021 ttcggaacga ttttttgctt gacgtttcgg caggcttgtt tactttgatc gccaagatga 814081 tcaggatgat cgtatcgata aagtaaaagg cgtcagtcgg tctcatcagc gaaaatgcgc 814141 tgtcaccgag ttggccgccg tttgttttag cctgcataat gaccggaatt gtaataaaat 814201 cattgaaaaa tctgtagtac acaatgttgg cgtacagtaa aaaagacatt aaaaaatgaa 814261 tcactataat ggctgtctgc tgtaattttt tcttgaacaa gagtccaaag ccaagaaaga 814321 acaagcttga gctaagagga ttcacaaaaa gcaatatttt ttgtatcgtg ttgtctattc 814381 ctaagttgaa attcaggaca taaccgacat acgttttgat ccataacagg acgaccgcaa 814441 ttaagaagaa ggccagtcct ctttctttta taaatgtttt cattgttaca ctcctttttt 814501 ccgatccagt tcgagcgaaa cgatagaaaa aacgaacgta tccaatataa cacgaatcag 814561 cagattagaa aagtgaaaat cgtatgaggg agaaagtggc gaaaaacgcc gtcgaatcaa 814621 cgtttcgctt tgatattacc aaatgtaaaa caaggtatct ttctagaaat aaaggaataa 814681 aatggtacat tgagaattgt atgataaaat ataaggtata gataaaaaga ggtgaaatga 814741 tggatttttc ccatattgtg tctgaagata aaattaagcg cgccatcaaa gacggggact 814801 ttcaaaacct cccgggaatg gggaagccgc tgccgaagga tgacgcggca cacttgccgg 814861 aatcgctgcg catgggctat cgtattttga aaaacgcggg aatggcagag gacgagggcg 814921 cgctcaaaaa agagcttatg accatcgacc atttaatcga aaagtgctat gacgaaaaag 814981 aacgcgagca attaatcaga aaaaaatctg aaaagcaatt gctgcttgat aagcttgtcg 815041 acaaaaaagg catgttttca aagccagcat ccgcttttta taagaataaa gtatatgacc 815101 ggcttggacg aaacagacct tcttccagct gatttgtctt gtctgcagga tggcgattga 815161 taaaagccat cctttttatg ttccaagttc tatgtcaaaa ggtttatgtt tttccatcta 815221 tgggaaatga ttcataaacg aaaaaagggt gatgggatgg aacgactatt agtatggata 815281 gagcatatat ctgattggct gtggggtccg ccgctaatca tcctgctgac ggggacgggc 815341 ttgtatttca ctattttgct gaaaggtttt caatttcgct atcctttata cattttcaaa 815401 cagacaatcg gcagtgtagg aaaaaagccg aagggagaag gcacagtcac accgcttcag 815461 gcattgacct cagccctcag ttcaacgatc ggtgcagcga acattgtcgg tgtgcccgcc 815521 gctattatgt ttgggggacc aggagcggtt ttttggatgt ggcttattgc cttatttgcc 815581 atggcgatta agttttctga aagtgttctt gctgttcatt acagagaaaa aaatgagcag 815641 ggtgaatacg tcgggggacc gatgtattac ataacaaaag ggctgcgcat gaaatggctc 815701 ggcgtattct tctctgttgc gctgattgtg gagctgattc ccagcattat ggttcaggga 815761 aattcggttt cagtctcgct tgccgagacg ttttctttca ataaaatata cgcaggaatc 815821 ggaattgcat ttttgattgg gttagtggtg ataggagggg taaagcggat cggaaaagta 815881 acagagtttg tcgtgcctct tatggcaggg gcatacgcag gtgccggtct cctgattgtt 815941 ctcatgaatc tatcatcagt gccggcgttt ttctctctcg ttttttcaaa tgcgtttacc 816001 tcttcttcag cagttggagg gttcgcaggt gctgcgttgg cggaaaccgt tcgctgggga 816061 tttgcccgcg ggctgtattc taatgaagcc gggatgggaa cagccccgat tgcacatgcg 816121 gcagcaatga ctgatcatcc tgtgcggcaa gggttttggt ctgtgatcgg cattgtcatt 816181 gacaccttaa tcatctgtac gactaccgct tttatcgtcc ttgcatccgg tgtatggaca 816241 gggaagaacg cctcaaatga cccggcagca ctgacaacgg ccgcatttca gcactatttc 816301 ggttctggag gaggatactt cgtttcggtt tccctggtct tctttgtcgt atcaaccatt 816361 atggttgtca ttttttacgg cgtaaagcaa gctgaatttc tgttcgggcg gctggcagga 816421 catgtgatta aattcgttta tttagcggct attatcatag gtgccgcagg cggagcaaaa 816481 gccatttggg gcgtattgga cttagcattg gtttttattg ttgtcccgaa tgtgattgcg 816541 ctcttgttat tgagcagaaa ggtaaaagcg ctgtacaccg aattctttac atctgaacag 816601 tactacctga aagatataag aaaaacgaaa caaaagcctg tttatccaac aaaagaagct 816661 aaaaattcct agtgttttgc ttttgcgccg aacaatgctt tgctttttat gatcaaataa 816721 atgagtaaag gcagcaaaag agaaatcact acattaatga ttggtttgat tctgttaaag 816781 tcgattagct gatttgtatt taaaaaaaac caaaagccgc atacgactga gaacatgccg 816841 gttggtgtat acatggcttt cgggtcgatt tttgagtgta aaaacgaaag gccgtatacc 816901 acgatatata gggaacctgc tatcttcacc ataatgaccg gaatccaaaa agccgcgatg 816961 atcaggtctg agcgatccag aaaatccgta atgcggatct gcctgatgac catataagca 817021 ggatcaaaga aagtagatgt caggttggga ccaaagacag aaattgaaga aaataacatc 817081 acggccagca ataaagcgcc cagcagtatc gcgaaaatgg tgtattttag cgggacgctc 817141 cggtttgaga agagaagcgg aaggataatc aattccccca ttgtcccaaa cgcgtaatag 817201 cctgattgaa ggtatgggat tagaccttca aaaacaggtg tcaagttttg aagctcaatt 817261 tgtgtggcca gcgtaaatgg aaggaacaag accaggatgc cgaatggaaa taggaatatc 817321 tgcgccattc tggtcaatgt ttcttttccc tctctggcaa tacagatcgc cacaaagata 817381 ataacaccgc caagaacagc cattggtgtt ctcgggagaa ataaaatgtt aatcaaattg 817441 atgaaaaaac gtatatcatg agcattgatt aacaggaaat acaaagaaaa cagtaaaatg 817501 ataatccggc ctgcgattgg tgaggaatcg ctcagcagct catagatatt tttatcctga 817561 tgctttttca tcagcctatg catgagccag agtgccggaa tcacgatgac aacgccgagg 817621 atgtagctgt gccaggcatt ttgttttgct gattcgatca tgagaatcgg agcatgcttt 817681 aatccgactg ctaacgtata cagagctccg aaaaataatc cttggtatgc agaggtcttg 817741 tccataaagc acatcctttc tgtcatgttc aaaacggaat atatttaaac aggtgcccca 817801 gccgcggaag caggggattc actctcatat aaatccatag aaaagcactt cctgcaatta 817861 gcaggctgaa ggcccatttt gttagattgt tagcggaacg aaaattcttc cattcatatg 817921 cgtatatggc aatgcacaca atcaatgtct gtacgatata gctgatcatg ctgacgcacc 817981 tccattaatg gctgatcgtt ttgtatagga caccgccctg ctcaatcgtc acaattggga 818041 cgacgtgaac ctccatatcc ttatatacct cttcccattc ctttttcagc agattcttcg 818101 tggttgccgt gcttctgatg gtcctgtctt gaaagccggc cgggtccgcc tttagctttt 818161 gcaaacgatg aacggtgctg atcacgtcct tctttatggt tctgtttaat gctttttgaa 818221 tgatgtaata ctggtcattt tctctcgtct cataggttga ttggttttcc ataataattc 818281 ctttggctct gatctcgatt gtcattgaca gctttccgtt tttttcagcg gcatgaaagg 818341 atgcattgga cttttgaagc tgaatggatg cttgccccat ttgattcggc aggtctacta 818401 tgaattctgg ctggcgggct tgattcagca acatcagggc tgctgtcatg tgttcatctt 818461 tgaaaatatc catcaatctg tcctttttaa agatcgcaag cccgtcaatt ttcaaattag 818521 atttgccttt ccctccaggt tttgttttag atgcagagat gaccggtgca tacggatcac 818581 tgcctatttc tactagatca gacatgaatc tgcttaagaa aacggggcgg ctcgttgcga 818641 taatggccag ctcccgaatc atttccgccg gaaactgttc aagctgaaca tcggtattta 818701 aaatgtcccg cgcttctccc cggctgacta aaatgagcgc cgttaatctg ttctgcggat 818761 ttcgcgttaa aatatcaaag actggggcaa cgccgtctct cgccatatcc tctccaataa 818821 tgactgtacg tctgtgggac gtattgattg tccgtgacaa ggaggtttgc agcttgttgt 818881 tcgcttctct gatcgtagtg ccggaagctg aatcaacata ccatgttttt gaaccggcag 818941 ttccgccgcc gccccctgtt tgtccgccta attggccgac caagggaatc tgcatggcca 819001 ctcgatactg atcttttttc ttatcaatgg ctgagctgac aacaaatgca atgtcattga 819061 tttctgtccg gtcccagcac cccgttagaa ggatacaaat gagaagcggc aaaacacact 819121 tatatattgt tttcttcatc ttttgggtcc tctcttttcg ctcccttctg tccgttgccg 819181 cgcgaatacg tgcccggcct tctggtcatc gtccaccaag gcgccctgac aaaaatatct 819241 tttacttcat ctcgtttaaa cggagaaatc ccggataaat aaggaatgcc gaaagattgc 819301 agcttgcata aatgaagcac taagataatc gtgccgagca taatgccgaa tatcccaaaa 819361 atactcgcca aaaacataag cgggaaacga agcatcctga tggagatagc taagttaaac 819421 cgcggaattg taaatgacgc gatccctgtt aacgatacga tgatcaccat gggggcagac 819481 acaattcccg cttcaacagc ggctgtccca atgactaggg ccccgagaat actgacggtc 819541 tggccgatgg ttttcggcag gcgcactccc gcctcacgga gagcctcaaa agaaatttcc 819601 ataatcaatg cttctatgat ggcggggaaa ggaatcggtt cacgcgcaga ggccacactg 819661 aacattaagt ttgtcggcat taagtcctgg tggtatgtaa taacggcaac ataaatagcc 819721 ggcaaatata aagcaacgaa taaaaacata tagcgaagcc agcggattaa gttagacatc 819781 aaataacgct catagtaatc ttcactggcc tgcataagct gccaaaacgt aatcgggcct 819841 gttaagacaa agggcgtatt atctgtgaaa atggcaaatc ggccttcgag aagctgggcg 819901 gcgacggtgt ccggcctttc tgtgtattgc agctggggga atggcgagta cgtgtcgtct 819961 tcgataaatt cttcaatata tccgctttct aagacagcat caatctttat ctttttgatt 820021 cttttttttg ctttgtcaat aacctttgga tcggcaagcc cgtcaatata ggccaagaca 820081 acatcggttt tggttttcgt gccgatttta aaagagatca ttttaagctg aaacgttttg 820141 acgcgaaagc gcacaagagc ggtattgacc ctgaggcttt cagtgaagcc ctctcttgac 820201 cctctgatgg tcgattctgt tatcggctct tcaatgcttc ttctttgtcc gccttttata 820261 tttaagatca ggccttttga gtgcccgtcg gcaaataaaa ccgcgttccc ctcaatgatg 820321 gatgcagcca ctttgctcat actcgtttct aatgcaacac ttgaaattga tagagtattt 820381 tgcagcgcct cttcatgttc atctatttga tccgtcaaat gcattaagaa agggcggagg 820441 gcgtgatcct gaatatgttc agattttaca attccttcga tataaacaat aaatccgcac 820501 agcccgtttc caaagtcaaa ttgtctaaat acgatgtctg agcagccttc tgttaataag 820561 gtcagatttt cgaggttttc cttcaaattg ggagagatcg gtctgtcctg attgtcttca 820621 agctctttga tgagctgaag cgctttgtcg cgtttattca tagaggctca ccctgctttt 820681 taatgtcata ttcaataagt gcttgtgact tttagggtaa ccttgtctgt ttcatatatt 820741 ccagactagg atgaaagcgc tataaaaaag tgttgactac ctgtatatac aggaatacaa 820801 tatgattata agttgtatat acaagttata aaaacggata cggaggggtt ggcatggggg 820861 aactgaacaa atcggcacgt cagattgtcg aagcagtcgg cggtgctgaa aatattgcag 820921 cggcaactca ttgtgttaca cgtttgcgtt ttgctttaat agatgaaagc aaggttgacc 820981 aagagatgct tgatcaaatt gatgtggtaa agggatcatt ctcgacaaac ggacagtttc 821041 aggtcgtaat cggccaggga actgtcaata aagtatatgc tgaactggtt aaggaaacgg 821101 ggattggcga gtcaacaaag gatgaagtga agaaggcctc agaaaaaaat atgaatcctt 821161 tgcagcgtgc tgtgaaaacg cttgcagata tttttattcc aatattgcct gcgattgtca 821221 cggcgggtct tttaatgggg atcaataaca ttttaacggc ggaaggcatt ttcttcagca 821281 caaaatcgat tgtgcaggtt tatccgcagt gggcggatct tgctaatatg attaacctga 821341 ttgcaggcac ggcctttacg tttttgcctg cgttaatcgg atggtctgcc gtcaagcggt 821401 tcggcggcaa tccgcttctc ggcattgtgc tcggggttat gctcgtgcat cctgatttgc 821461 tgaatgcgtg gggatatggc gcggcagaac aaagcggaga gatcccggta tggaatctat 821521 tcggcctaga ggtgcagaaa gtcggctatc agggccaggt gctcccaatt ttgcttgctt 821581 cttatatgct ggcgaagatt gaggtatttt taacaaaacg cacacctgag ggcatacagc 821641 tgctcgttgt cgcaccaatt acgcttctct taacaggatt tgcctctttt atcattatcg 821701 gcccgattac atttgcgatc ggtaatgtac tgacttcagg gcttatctcg gtgtttggtt 821761 cttttgccgc actgggcggt ctgttatatg gcggtttcta ctcagcgctc gtgattaccg 821821 gtatgcatca cacgtttctt gcagtcgacc tgcagctcat cggttcaaag ctcggcggca 821881 cctttttatg gccgatgctg gcgctttcta atatcgcaca aggttcggcg gctctggcca 821941 tgatgtttat cgtgaaggat gagaaacaaa aaggcctctc cctcacatca gggatttctg 822001 cttatcttgg cattacagag cctgccatct ttggggtgaa tctgcgatac agattcccgt 822061 ttatcattgc aatggtcagc tctggcctgg ccggaatgta tatttcttct caaggtgtgc 822121 tggcaagctc cgtcggtgtc ggcggcgtgc cggggatttt ctcaatcatg agccagtact 822181 ggggcgcgtt tgcaatcggg atggctattg tattgatcgt gccgtttgcc ggaacatacg 822241 cgtatgcgag attcaaacat aaataacaag tggggagcgg gacgtgttga acgttccctt 822301 ttcccgtttt caatttaaat atggtggtgg aaacagatga aaacagaaca aacgccatgg 822361 tggaaaaaag ctgtggttta tcaaatttat ccgaaaagct ttaacgatac gacaggaaat 822421 ggtgttggcg atctgaacgg cattattgaa aagctggatt acttaaaaac gctacaggtg 822481 gatgtgcttt ggctgacgcc gatttatgat tctccccagc atgataatgg gtacgatatt 822541 cgtgattatt actcgattta tcctgaatac ggaacgatgg aggattttga gcggctagtg 822601 tccgaagcac ataaaagaga cctgaaagtc gtcatggatc ttgttgtcaa tcatacgtca 822661 acagagcaca aatggtttcg cgaggcgatc tcttcaatag acagcccgta ccgtgatttt 822721 tatatatgga aaaaaccgca ggaaaacggt tctgttccga cgaactggga atcgaaattc 822781 ggcggctcgg catgggagct tgacgaagca tcgggccaat actatttgca tctgtttgat 822841 gtgacgcagg ctgatttgaa ttgggaaaat gaagaggtca gaaagcatgt ctatgacatg 822901 atgcattttt ggtttgaaaa gggaatagac ggctttaggc ttgatgtcat caacctgatt 822961 tctaaagatc agcgctttcc gaatgcggag gaaggcgacg gccgctcttt ttacactgac 823021 gggccgcggg tgcacgaatt tctgcatgaa atgaacgaaa aggtgttttc acattacgac 823081 agcatgacgg tcggtgagat gtcttcaaca accgtagacc actgcatccg gtatacgaat 823141 cctgacaata aagaacttga tatgacattc agcttccatc atctcaaggt tgactatcct 823201 aacggcgaaa aatgggcctt ggcgccgttt gattttttga agctgaagga gatcctatct 823261 gactggcaaa cggggatgca cgcaggaggg ggatggaacg ctctgttctg gtgcaatcat 823321 gatcagccgc gcgtcgtatc aagatatgga gatgatggcg catatagggt gaaatcggcg 823381 aaaatgcttg ctacggccat tcatatgatg cagggcacgc cttatattta tcagggcgag 823441 gagctgggga tgacgaatcc gaagttcact gacataagct cctatcggga tgtcgaatcg 823501 ctgaacatgt atcacgcctt taaggaaaaa ggaatggctg atcaagatat tacagccatt 823561 ttacaggcga aatcccgtga caattccaga acccccgttc agtgggatgc tacggaaaat 823621 ggtggtttta caacgggcac accatggata ccggttgcag gaaattaccg ggaaatcaat 823681 gctgaagcgg cgctgaggga tcagaattcg gtgttttacc attatcaaaa attgattcag 823741 attcgcaaaa tgtatgacat tgtgacagag ggtacgtatg agataattgc aaaggatgac 823801 ccgaacattt ttgcgtatct cagacacggc agcaatgaaa agctgctcgt gatcaataat 823861 ttttacggga cagaggcggc ctttacactg ccggactctt tagcgcctga cgaatggaag 823921 gcagaggtgc tgttgacgaa cgatgaagca agggaagggc ttcagaacat gacgcttcgc 823981 ccatatgagt ccattgttta tcgtttaacg aaaccgtgtt aaactaagct gggtggtcca 824041 taatgaaggt gaataaattc atcacaattt ataaagacat cgcacagcaa attgaaggcg 824101 gccgatggaa agcggaggag attcttccgt ctgaacatga gttgaccgca cagtacggta 824161 catcaagaga aacggtccga aaggcgcttc atatgctcgc gcaaaacggt tatatccaga 824221 aaatcagggg aaaaggctcc gtcgtgctca atcgtgaaaa aatgcagttt cccgtttcgg 824281 gccttgtcag cttcaaggag ctcgcgcaaa cgcttggcaa agaaacgaaa acaactgtac 824341 acaaattcgg gctggagcct ccgtcagagc tgatccaaaa acagctccgg gccaatctgg 824401 atgacgacat ctgggaagtc atcaggtcta gaaagattga cggggaacat gtgattttgg 824461 acaaggatta ctttttcaga aagcatgtcc ctcacctgac gaaagaaatt tgtgaaaact 824521 ccatatatga atatatagaa ggagagctcg gtctttcgat cagttacgcc caaaaagaaa 824581 ttgtagccga gccgtgtacg gacgaggaca gagagctgct cgatttacgc ggctatgacc 824641 atatggtcgt ggtgagaaac tacgtctttt tggaggatac cagtttgttt caatatacgg 824701 aaagcagaca ccgtctcgac aaattccgat ttgttgattt tgcgcggcgg gggaaatgag 824761 agaggcgcct gcctgcggca gcgcgctttt ttgtttggta tcaaaattga tactatccaa 824821 caaaaatgtg cgtactttta ctttttatca taatggctac aatagagatg agagtaatct 824881 aaaggagagg tgttttacat ggcagatcta aagacacaaa ttctggatgc atacaatttc 824941 aggcatgcga ctaaggaatt tgacccgaat aaaaaagtgt cagacagcga ttttgaattt 825001 attttagaaa caggaagact gtctccgagc tcactcggcc ttgagccttg gaaatttgtc 825061 gtcgtccaaa atccggaatt ccgcgagaag cttcgtgaat acacatgggg cgcgcaaaag 825121 cagctgccga ccgcaagcca tttcgtcctg attcttgcgc gtacagcgaa ggatatcaaa 825181 tataatgcgg actacatcaa acgtcattta aaagaagtaa aacaaatgcc tcaagacgtg 825241 tacgaaggct atttaagcaa aacagaagaa ttccagaaaa acgatttgca tttgcttgaa 825301 agtgacagaa cattgtttga ctgggcatca aaacaaacct atatcgcgct tggcaacatg 825361 atgactgccg ctgcgcaaat cggtgttgat tcctgcccga tcgaaggctt ccagtacgat 825421 cacattcacc gtattcttga agaagaaggc cttctggaaa acggaagctt cgatatttct 825481 gtgatggtgg cattcggcta ccgagtgaga gaccctcgtc cgaaaacaag atctgctgtt 825541 gaagatgttg tgaagtgggt ttaaaagaag aaagctgctc gcatagcgag cagctctttt 825601 ttatgcctga ttcgctctat tctgttttct cctctgatgt aagtacattg ccgttccgag 825661 tgcgctgatc agaaatccgg ccaacaggat cgagtacatg gatgtggctg tgtccggaag 825721 caggccgcca gccggaccgt ctgttcctga tccgcccgaa ccgtttccac cagagccgtt 825781 agtcggttga gtgccgggag gcgtatcatt tcctccgttt ccgtcagttg gctgttttcc 825841 gcctggtttg tcggagcctc cgccatgatt gccgtcatca ccgcctgtcg gttgatctga 825901 cgggaatgcc ggcggtttgt tgtttgaacc ggaatttaag atcgtgtatt cgctgaagtg 825961 gtttgtatat cctgtcacca tatcatcatc gactgatccg tgacctgtct ttgtgaaagc 826021 tttctttttt ctatcgacgt gataaatggc agggttatgg gcttcttcaa tatcaaacat 826081 gcgaagcgaa agctgtacgg gctccttgaa tgattttatt tcttttcctt tttgcttcac 826141 tgtaaagtca tatacatctg acagtgacac atccaattct cccgtagact tgattccgat 826201 tgcagtgtct gcggttttaa ggttcgccat tggcatcttc atgctgtacc agtagttgaa 826261 catcgtcaat gaaggatctg actctctttc tttcaaaagt ttgacctgat cttttttcac 826321 tttaagattg ataggcttct cttgagatcc ttcatgtatt ccataataga caaatggcgt 826381 gttggcattt ttagcataaa tcgcaaattt gtcttcatca agtgtccagc tgccgtcctt 826441 ctgctttgtc ggcaggaata cttctttgat tcgtccttca actttaggag agaccttgtt 826501 tcctagtttt ttcagctgtt cggtgaaaat ctcataatca acgtagccaa ggtcttcacc 826561 atgggaggct tctgtaaaga cagaatatcc gtctcctccg gcaccgacaa aattatttgt 826621 tgccacgcgg taggtatcat ccgtatttat agcaactttg tctccgttag gcgattcaat 826681 tttcacttct aacacacggt gtccaggttt gttgtttaat gtaaaggtat attcgattcc 826741 ggccacctga gggaaagcgc cgccgccatt ttccacattg cttaggcctt gttcaagggc 826801 ttctttaatt tgttttccgg ttaaatcggc cacgtaaagc gtattgccga acggcatcac 826861 gttgagcacc tcgccgagtg tgatatcacc tttgtcaatg cctgctctga tgccgccgcc 826921 atttgttatc gctattctgg cgccggctgc ttctttcgct tttgccagca taccgtccgc 826981 gatgaagttt ccgagattcg tttctttcgt gcgcacatgc tcacgctggc cgtcaagcgc 827041 cacatccgtg tagccgactt tttcattttt cacgtcctct aattcatttt tgaactgatc 827101 gagctcttgt tttgcttctg ggttttcttc tgtatgttca tcaattggca gcacgctcag 827161 atttgattta tctgtttgca caacgccttt ttcatcaaac gcgacatcaa cgcgccccaa 827221 gaattggccg tattcttttg cctgcgccac gatcgtcggt tcttcgttgt tcacgacctc 827281 cattttgtct acgagggtgt gagtgtgtcc gccgatgatc aaatcaatgc cttttacttt 827341 tttggctagc tcaagatccc ggttatgtcc gatgtgggtt aaagcaataa ttttatttac 827401 cttttcttct tcttgaatcg ctttgacggt gttttgtgct gtttcaaagg catcattgaa 827461 tacgatgctt ttgcccgggc ttgatgtggt ggctgtatct tctgttgtca ggccgaatac 827521 ggcgactttc tccccgtcaa cgtctaacag aatgtaaggg tgaatgccgg cctctttctt 827581 ttcacctgcc gtaaaggttt gcggcttttt gacaaatgat ttcagcttgg gctcatttga 827641 cacatctacg tttgcactga caatcggaaa ttccggcgct tcaaagtgat agcggttcgc 827701 cggatcaacg gttgcgctgt ttccgcttag aaaatcagaa agcaccgtcg ggcctttgtc 827761 aaattcatgg tttccgaagg tcatggcgtc atagcccatc atgttcatca ttttcagatc 827821 ggccaaaccg ttccatttag taaaatacag atcgccggaa aacacatctc ccgcatcaag 827881 gagaatattg tgatttgttt cgctgcgtac ttcgttgatt ttcgtcattc gtctcgctgc 827941 atcatcgaga tgggcgtgcg tatcattggt gtgcatgacg gtcagatccc acagtccgtc 828001 tttaggagga tctggatttg aatcatcatc gaattgcagc ttatacacac catagccttc 828061 attcgcagac ttgcctacat aagcgacatc gtctgcttta tcggcaaatg gcttggccaa 828121 aagcgaggat tcaaacgtca gattcgtgcc ggaaacaggc gcgattgacc agttgttgtc 828181 tgcttttgga ttgactgttt tttgttcaat aatgtaatcc atcagcacct gcctattttc 828241 aactgcagag ccgtggacaa ttttatcgct cgtcagatga gggaacccgc cgcctccgga 828301 cgcacgatag ttattggtga ctacgagaaa ttcctggctt gggctgatcg gcttgccttc 828361 ataggaaaga ttgatgatac gggatgaatc cgcattgatc acttttccgt tctcattgta 828421 tttagccggt tttgtcacat cgacctgata tgtgacaccg tcaatcacgt caaaattata 828481 ggagcggaaa ttctcgttca gcaaggcctg gtcgccgcct ttagctggat caatttgatt 828541 gaattggcct gctgacatct ccagccagtc cttgacctcg ctgcctgtca gcttgacgat 828601 ttgaacagta ttatcgtaaa gatacaagtc accgacattt ttaatcgcaa gatctccggc 828661 tggaatgttt gtatagtaat tggctccgtt tctgccgcct gctttaaacg gcgctccagc 828721 ggataaaatc ggcaggttct tgtactcggt atccttcatt tctttttcag cgtaccactt 828781 ttgcgcgtca gtcacgatct gaatggaagg atcatctttg acctgtgcaa agaagctgtt 828841 aatatctgct tcggttttgc cgactggctt tcggacatac tccagtgtgt tttggtgtgt 828901 ttgctgaatg gtgtttgtaa cggtttcgtt tcttgatgtg acgttgccag caatagattc 828961 aatacttcct ttggaatctg ctaccttcca tgagccgtcc gccttttcaa gcttgaggtc 829021 aatcacgcct aaatatttgc cccagctgct tggcatgacg acaggaatgc cgttaattgt 829081 tcccttttcc acattgaact gagcaacacc cgcatactcg gcggaaggaa agagtccgtg 829141 ctgatggccc gagataatcg cgtcaatgcc tttcgttttg gtggcaaggt caaacacggc 829201 gttttctgcg cctgatgatt gcgcctgctt ttcaatgccg gtgtgggcga gggcaataat 829261 gacatctgcg ccttccgcct tcattttcgg gatcgtttca ttggcggatt ctacgatatc 829321 ctgcacctga acttgcccct cgagattctt tttgtcccat gtcatgattt gcggcgggac 829381 aaagcctatg tagccgactt ttactttctg ctcattaccg ttttcatcaa tgagggtttt 829441 ttcattaatc acatacggcg tataacggtt ttcgccgcta gttgttttga cgttggcatt 829501 tacaatcggg aaatcggctc ctttgattgt gccgtcgaga aagtcgagcc cgtagttgaa 829561 ttcatgattg ccaagcgttc cggcgtcgta tttcagcgca ttcatgacgc tgataatcgg 829621 atgggttttc gtgccggaga taatgtcgtc tttttgatat ttcaccgcgt attcacccag 829681 cggattccct tgaatcaagt cgccgttatc cacaagcagg gtgttagggt tttgctcgcg 829741 gtgcttttgg atcaattgcg ctgttctcgc cagaccgaaa tccgccgttt ctttgtcgct 829801 gtagtaatcg taatccatca tgttggcatg aatatcagtc gtagccaaaa tactcagatg 829861 cacctgagga gccgcgcttt cttctgcatg aatgggtggt gttgggagga ttaggctaag 829921 tatcataatt gggggcaaaa gaatacggag aatgttttcg acgtgtgttc gtcttttctg 829981 tattctcacc agttctccac ctttcaacga aatttgtgtt acagctccta ttgtaagaat 830041 attttgtaac tatttgtagg tgtttcttta tgattattgt aaaagggaga aaaatgagta 830101 ttatgtagca gtatcaaacg acaaatactg ggcatttatg cttatcgttt gtcacaatcg 830161 cggaatgttt attttagtgt ggctggggta gagtgtttta tgtagacata taaagcggga 830221 ggttatgaat catggggaaa aaaattgcag ttgttttaac atattatttt gaggacagcg 830281 agtacactga gcctgcgaaa gcctttaaag aagcgggaca tgaactgact gtcatcgaaa 830341 aagaaaaagg aaaaacagta aaaggcaagc agggaacagc ggaagtgacg gttgacgcgt 830401 ccattgacga cgtaaattct tcagactttg atgcgctttt gattcctgga ggattttcac 830461 cagaccagct tcgcgctgac gatcgtttcg tccaatttac aaaagcgttt atgactgaca 830521 aaaagccggt atttgccatt tgccacggcc cgcagctttt aatcaatgcg aaagcgctcg 830581 acggccgaaa agcgacgggc tatacgtcca ttcgtgttga catggaaaac gccggtgccg 830641 acgttgtgga caaggaagtg gttgtttgcc aggatcaatt ggtcactagc cgcacaccgg 830701 acgatatacc ggcatttaac cgcgagtcat tggcattgct tgagaaataa gaaaaaacgg 830761 acgctcttgg gcgtccgttt ttttgttgct taggcttgag cacctgtcag tttcttgtac 830821 ctgtaataca agaaagcagc tgcagccgtt ccgatgaccg caatgccgaa gtcgaatatg 830881 aaaatatggg cgatgccccc cgcttttgcg ataagccctg ttgcaatcgg cagcagaatc 830941 gatgcaagac ttgaagcagt cgctacaatt ccggtaacgg ttccttttcg cttccagaaa 831001 agctctgtca ttaacgtaat ggtaatttga aacacacccg cagttgaaaa gcctaagaaa 831061 aaggcagtga tgtccagcac aactgggata tgaacggtca gcatgactgc gagcgtacat 831121 aaagtaataa taggatataa gagcgttatg aagacaggtt tgacccatct attcagcaaa 831181 acggctaata ataaaacaga tgccagagat cctatactat aatagctcag caattgtaca 831241 gatgctgatt cagctaaacc ggctgccttt tgcgcgtagc tcgggagcca gatttgagaa 831301 accgtaaata aagccgtgga tgtaaaaccg atgataatca gtgcggtgcc ttccttctga 831361 aaaacgggtt cagacaagaa aacgggagat tcctgttggc cgctattagt tggtttctta 831421 tgttttttag gaaacgaaag cgttgataaa taaataatat tcaggagata gaccgctgcc 831481 ggcagataaa aagcaaatcc gtaaaacatg ctgtggtctg ctaaaaatgt gatcaaaagc 831541 ggcaaaagtg cggcccccac agacataaag gctttaacca agacatttgc cgaaccggaa 831601 gcagacggaa agagctcggt tagggccgga tatgttccgg catccatggc tgaattagcg 831661 actccggcta ataaagcgaa cacaaacgcc agctcatagc tcggtgataa aggaataccg 831721 actaaaaaga cggccataat tcccgcagaa gcgacaacaa gcggctttct gccgatttta 831781 tctgatagaa cgccggaaat gccgtatgtc agcagtttgc caaacccgat agcggcaatg 831841 acataactga tgccggtcgg atcggtattc cactgttttg ttaatgaaga catattggat 831901 gcgagaatga tgttgaccat ccccagaaag aagtagttga tatacattcc ggatgctgtt 831961 ttgatagatg tcgtttgcat gcttgtactc cttcaaatct tattcgaaca ctttgctgtt 832021 ttggtttggg gaaatgataa aaaagactcg ccgagtttcc ggccagtctc cattatttac 832081 gaagcgaggc taattcttga gcaatcgcct gcatttcact tgggctgaat gattcttttt 832141 tcatcaccat tctgtgaagg tacgtgaggt cttcaatctt ctcatcactg aaatcctccg 832201 ctttgattac gccgacgttc agcatgttca gcttttggga aatctcttca atcatttgag 832261 ttaatgtttc tgtatttggg ctggacaaag ggttccatcc tttctatgcg caatataggt 832321 atgttttatt ctaacagaat tccatcagaa aaaaacccta ttctaaaagc aggctgttca 832381 ttccaaaaaa gtgaagacat cagttgaaaa gaaaatgaac atcctactaa gatattcatg 832441 aaggtttctt tttagagaaa taggggcaaa gaatagggag gttgcacatc atgataagcg 832501 tgttatttgt ttgtttaggt aacatttgcc ggtctccgat ggcggaagcg atttttaggg 832561 acctggcagc caaaaaagga ttagagggga aaatcaaggc ggactcagcc ggtattggcg 832621 gctggcacat cggcaacccc ccgcatgagg gaacgcagga gatattgcgc agagaaggaa 832681 tcagctttga tggcatgctg gcgcgtcaag tcagcgaaca ggatctggac gattttgatt 832741 acatcattgc aatggatgca gaaaatatcg gaagtctcag aagcatggcg ggttttaaaa 832801 acacctcgca tatcaaaagg ctcttggact atgttgaaga ttcagatctg gctgacgtac 832861 ccgatcctta ctacacaggg aactttgaag aggtctgcca attaatcaaa acgggctgtg 832921 agcagttgct tgcatccatt caaaaagaaa aacaattgtg agtgaaagga gaatttgcat 832981 gaacaacgaa cgtttaatgc tgaaagggat atttctcgga gctgcggcag gcgcggcgtt 833041 atcactgctc cataagccga caagacaggc gtgcgggatg agatggctga catgcaagca 833101 taaactttca ctgtacaaaa gcaacccaga gctgttaaaa aacactgtca tcacaaaagt 833161 ggatgaggcc aaaaagctcg cccgaacgct ttcaaaggaa gtcgactttg tgaaccagca 833221 ggtgaaagag ctgaagaaaa caacgccgca agtgatggaa ctcgtgcaag aaacgaaaga 833281 gcatttttca aaaaaatgat caaacatgcg aggtgagacg acatgagttt tttgaaagag 833341 cttttcagca gatacaccct tcatgaagga caaagtaaat cagcggagct ggcgtatttt 833401 tttctattgt cactgtttcc gtttttgatt tttatgctga cgctcaccgc gtatcttccg 833461 ctttctaccg atgatgtttt aggagtcata gaacaatatg ctcccgccag tgcgatgtca 833521 ctcgttgaat ccattaccca tcaaacctta aataatcgaa atggcggttt gctgtcattc 833581 gggattatcg ccgcattatg gtctgcgtct aatggaatga atgcgatcgt ccggtcgctg 833641 aaccacgcgt atgatgtgga agaaaaccgc tcttttatca ttgttcgtct aacctcgatt 833701 tttttgacga ttgccatggt atttacgatt ttagtggctt tgcttctgcc ggtatttggc 833761 cgggagattg gaaggctcgc ttctgacttt gtcggcgcgt cggatctgtt tttatccgtc 833821 tgggccgcca ttcgctgggg tgtcagcccg cttgtgcttt tgattgtttt ttccgcgctg 833881 tatgtgattg cgccgaacaa aaagctgtct ctccggtttg tcatgccggg tgcggtcttt 833941 gcgactatcg gctggatcat tgtcagcaca ttgttttcat tttacgtcag cacgtttgcg 834001 aactatagcg ccacttacgg gagcatcggg ggaatcatcg ttctgatgat ttggttttac 834061 ttgagcggca ttttaattat cctaggcgga gaaatcaacg ctcttttaca taaacgtaaa 834121 aagcttcctg atgaaaatcc ctaccattag cgcaccctat aaacgaactt cggttcaaaa 834181 agaagtcggg gggatatcgt gatgaccaag catacgaaaa aaggcggaag ccataacaaa 834241 caaaactcga aaagcaaatc gagccataaa acaagcggaa gcgccaacgg acaaaacggc 834301 taccattagc ataaaagcct cctgacatga tgtcgggagg ctttttgatt aagaagatga 834361 agaataggtt tcagccggtg accagctttt cggtttgccc agcacaaggg ccagccacac 834421 agagctaagc gtgagagtaa tgaagtagaa caagtttgcg ctttcaaatg tctgcatata 834481 ccagccgccg gcaactgggc cgaggatgct accgagactg aatgtaatgc cgcaaagcag 834541 gtttcccgcc ggcaggaggt gaggcggaag aaggtctgtc atatagctga tgccaagtgt 834601 aaaggttgat ccgactgcca ttcctgcaat aaaaaagcag ccgccgatca cgtagggcga 834661 aggaaataca ccggcgatga aaaagcaaag agccccagtc agtaaaatca ccagcagcac 834721 attccgcctg ccgtatttat cgctgaggat gccgagcgga aactgaaaga taatgcttcc 834781 aatcgcaaat gcgggaagga tgatcgctac tgcgtctact gatatcccca aacggagcgc 834841 gtacaccgga aagcttccgt tcagcgccgt ttccagaaag ccatagccaa atgtaggcat 834901 aaaggcaacc cacccaaaca gcatggcctg ataaaatcgc ctgaaactat tgtctgattt 834961 ggtttcatga ggactggttt ccgggtatgc attttgtaga aagaaaacaa aaagccacgc 835021 aaacagactg atgcagccgg acacgataaa aggaagcgac ggactcagct tgacaagcgg 835081 caccatgaac gggcctgcgg caaagccaag gccaaaggaa agcccataaa tagacaggtt 835141 tcttccgcga ttttgttttg atgacatgga ggtcacccac gtttgcgtag aaaagtgaag 835201 catgtggtcg ccgattccaa tgaacaggcg aagcaggaac cagacccaaa ctgactgaag 835261 ccaaataaat ccgaataagc ttaaaatgac aatgcttccg cccatgacga tcagcggctt 835321 gaacccgagc tttctgagcg gtgcttccat aaacggcgaa gccaaaagca caccgatata 835381 cagcccggtc gcgtgcaggc cgttgatagc agcggattct ccatttgttt caaaaatgat 835441 tgaaatgaca ggcagcagca tgccttgtga aaacccggaa atggaaacga gcaagacaag 835501 gataaagaaa tgaaatcgtg acatcgtgtc agttctcctt atatggaatc tatgttgatc 835561 gtacaacgtt ttccaaaagc aggcaacctg aaaaaagcct atatcacgct atacatttgc 835621 cctcgtgtaa tcatgaaggt ttttgtgaag aataaaaata aaacaagtca taaaaaagga 835681 gctatttcac catgaatcgt atctttttta ttttagtggc ggccggtgtt ccgctttctg 835741 tgattggcag tttgatgcat tggccttccg cggttctatt tgcagtttat tgcgtgacga 835801 ttatcgcgct tgcaagctat atggggaggg cgacagaatc actgtccatc attgcaggac 835861 cgcgtatcgg cggtttgttg aatgcaacct tcgggaatgc ggtggagctg attatttccc 835921 tttttgcatt aaaagaaggc ctgacaggaa tcgtgcttgc ctctttaacc ggttcagtgc 835981 tggggaacct gttgctggta gcgggcctat cgttttttgt cggcggttta aaatataagc 836041 ggcaggaatt taatatccat gatgcccgcc ataactccgg gcttctgatt tttgccatca 836101 ttgtcgcctt tgtgattccg gaggtattct ctgttggtat gggaaacgcc agcaagctca 836161 atttaagcat cggcatcagc atcattatga ttctgttata tgtggcggcg ctgtacttta 836221 aacttgtcac gcatcggggc gtttatcagc cgaataatgc cgctcagact gaagaagagg 836281 aagagccaga atggtcaggg aaggttgcga cgattgtctt gtttgcggca acgattgtgg 836341 ttgcatacat atccgaaaac ctggtccata cctttcactc ggtggctgaa cagttcgggt 836401 ggagcgagct gtttattggg gtcatcatcg tggcgattgt aggaaatgcg gcggagcatg 836461 cgtcagcgat tattatggcc ttcaaaaata aaatggacat tgctgttgaa attgcagtag 836521 gctctacgct gcagatcgct atgtttgtcg caccggttct cgtcatctgt tctatctttt 836581 ttccgacaag catgccgctt gtatttacat tgcctgagct cgtcgcgatg gtatcagcgg 836641 ttctcttgat gatcgcgatt tcgaatgacg gggattccaa ctggtttgaa ggggcgacac 836701 tgcttgctgc atatgtcatt atggcgatcg gctttttcct tctttaacct gaaaaaatga 836761 tggataacaa caaagcggga tgaaaagact aagggaaaat gccatagaaa gagtgatatg 836821 atgaaaaagc tatttcattc cacacttatt gtgttgttat tctttagttt tttcggcgtt 836881 cagcccatcc acgcgaaaaa gcagtttaag gttcctaatt ctgtcgcaag catttcaaag 836941 gaaaacacgt atccgaatgc ttcacaggat cagccaatgc ttcagccgag caagctggca 837001 aaggaattgc tcgatcattc tgaggtaaag attgaaaatc cgcatctcat caaaatgctg 837061 aatgaatcca acatatccgg cacaccgctt gcagtagggt accgggcgac aatatttctc 837121 gggaaatggg cgctcggcta tgaatcaaat gaaacagtcg caaactggga atataaaaaa 837181 atcaatacaa accgtgcgga taaccgcggc gggaaagaaa cggctgaaat gcattatgcc 837241 caggaacagc agtacagagt gaagggcggc ttgacagcta aagttccaaa tgctgaagat 837301 gtcaaaagca tgatgatgca aaaagcaatg aagaaaacga acctcccgct tgcatttgag 837361 acggtcatcg gggctggcac aaaacgggat cagatttata aagtcgctcc taaaaaaatc 837421 ggttatctac atgcatatgc accggctgtg aatgaaaaag gaaaagtgac ttacggagaa 837481 gtgtacttag tgctgaaagg aaataaacga aaactcgtcg tgaaaaatgt cacgtcacag 837541 ggaatcggcg cgtggattcc ggttcaagat catgtcacgt ttggctttca gctttcctca 837601 ctgccaagat aaataaaaaa ctgattccaa ctcggaatca gtttttttgt ttattgggtt 837661 ctctcgattc ggaccgcttc ctcaagcatt tgcacattgt tttggtagag ctggcgaacg 837721 agaacccgtc ttactgcaag gctggcactg aaataatcat catctttcac catgccttta 837781 accgtaaatt cgacgccgcg attgatttta ttcaatgcgg tgatgccgtg gatttgaaac 837841 ggttctgtcg gattgccgaa ttcatcccgc ttcaatgaat cacgaagctc ttcattcagc 837901 atgtcacatg cctcttccaa cacgctgtac acgcggtccg gatcttcttt aaagctgata 837961 agaaaggatt cggtaatccg cataaaatca atattatagt tctctatttg tctgacctcg 838021 ccgttgctga tggtgagcag cttcccgctc cattcccgga tttgcagcga gcggaggccg 838081 atttcctcca ctgtcccgtt gaacaagttg ttgacggtga cataatcgcc tttgtgcagc 838141 tggcgttcat atattaagaa tacaccagcc agcacatctt tgatcagcga ttgggcgcca 838201 aaaccgatca cgatacctgc tacgcccgcc ccggccaata tcttgccgaa atcatgcaca 838261 aataaagaaa taacgtaaaa gataaaacca attgttgccg tatactgggt gacagaacgg 838321 acaaggcttt caatcgtttt ttcctttttt tcttcaataa agtccgtccg tttaaaaaat 838381 agctgtacca gccggttgat gataaagaca ccgatccaaa ggataacggc aacgaggaga 838441 atatcgacga ttttattttg aaaaatctcc gtaagtgttt ctttcatccg catctaactc 838501 ctggcttgac gttttgtgaa gtctgtatcc tgataataac tgtttttgac aagaacattc 838561 ggtccgaggc accggacatt cgggcagtgg caactcagtt ctttcgcaag cttggtctct 838621 ctccactttt cataggcgga agggaggctg tccgtctgaa tgttgccaag cggcggggta 838681 tcaccgaaat cggtcacgat aatgtttccg tcgaaaatgt tcacattcag gcgggatcgg 838741 ccgtcagggt catttcgcac tgtgacgttt ttcgccgcgc gaagccggcg aagcagcttt 838801 tggtcgtctt cgtccggact gcaggcataa aacggcagcg ttccgaacag catccacgta 838861 ttttcatcac gaatatccag caagcggtga atggcctgtc tcatctcttt caggctgagg 838921 gattcaagag cgcttgcgaa atcgcttgga tacattgggt ggacctcgtg acgctgacat 838981 ttcatatctt ctgtgatttg gcggtgaata tgctcaatat gcggaagtgt tcgtttgttc 839041 agcatcgttt ccgcagatac cattactccg gcatccacga gcgtgcggct gttttcgatc 839101 attttttcaa aatagcgcgc gcgctgttcg aaggtcggtt ttctgtccat catggcaaag 839161 ccgatttcag caaaatcttc aactgttccc cagttatgtg aaatatgtag cacatcgaga 839221 tacggaatga tccattcgta ccgctcgatg tcgagggtca gatttgaatt aatttgtgtc 839281 cgcacacccc gttcatgggc atatttcaat aaaggaacaa catattcttt tactgatttc 839341 aacgaaagca tcggctctcc gcctgtgatg ctgatggatc tgaggcgcgg gatttcctcc 839401 agccgtttta acagaagatc tattggcaga gcattcgggt ctttaggctg caatgtatag 839461 cctacagcac aatgctcgca tctcatattg cacagtgtcg ttgttgtgaa ttcaacgttt 839521 gtcagctgca tgtctccgta ttggtcaaca tccatatagg cttcccaagg gtcaaactcg 839581 ggcgtaatcg gacgcagctt cgtgttttgt gtcatgacta tctaactcct ttataaatgg 839641 gcatactaac gctgccaaca gttaatttta gacctgattt gccaagatcg caagtagcgc 839701 ggcgattgaa aaacggcaaa aaatgagcta ccataataaa aaatgaatgg aggaacagaa 839761 tggggaacgc cgtaaacaat aaagatcagc agattgatta tttaaagaac agacttgaca 839821 tgtttatgaa cgtcatcgat tcattagacc ctgaagcaac cgacgttgaa gatatagaca 839881 ggcttatcag catgcttgat gacctggaag ccaaatacga acgttttaaa aaagattggg 839941 aataaaaccg cgtgcccgcc gcggtttttt tattggcata aagcaacagt ataaaacaaa 840001 gtctctatct gtaaaataag aaaaaatgca gaaggagcgc tggccatgaa gtggatgtgt 840061 tcaatatgct gcgccgccgt attgcttgcc ggaggtgcag cacaggcgga agcggtgccg 840121 aatgagccga ttaattgggg ctttaaacga agtgtcaatc atcagccgcc agatgccggg 840181 aagcagctga acagtttaat tgaaaaatat gacgcgtttt atttagggaa tacaaaggaa 840241 aaaacgattt acttaacgtt tgataacgga tatgaaaatg gctatacgcc aaaagtgctt 840301 gatgtcttaa aaaaacatcg cgtaacagga acgttttttg tcaccgggca tttcgtaaag 840361 gaccagcctc agctgatcaa acgaatgtca gatgagggcc atattatcgg caatcattcc 840421 tttcaccatc cggatttaac gacaaaaaca gctgatcaga ttcaggatga acttgattca 840481 gtcaacgaag aggtttataa aattacggga aagcaggaca acctgtattt gcgtccgccg 840541 cgcggcgtgt tcagtgagta cgtactgaaa gaaacgaaac gcctcggcta tcaaaccgtt 840601 ttctggtcgg tcgcttttgt tgattggaaa atcaacaacc aaaagggaaa gaaatatgcc 840661 tacgatcata tgatcaagca ggcgcacccg ggagccattt acctgcttca caccgtatcg 840721 agggacaatg cagaagcgct ggatgacgcg attacagatc tgaaaaaaca gggctacact 840781 tttaaaagca ttgatgatct gatgtttgag aaagaaatga ggctgccgtc tttgtaaaag 840841 agaaagacct ctccttaaac ggagaggctt ttctttattt tatacattta atcagtgcgg 840901 cccagtccag atccccgaag cctttctcaa tcccgctttc aaaatggctc ttggccagct 840961 cggcaagagg aagatttgca gaaacccgtt ttgcggcggc gagtgccagg ttggtatcct 841021 tcagccctaa agacattttg aagccggccg gctcaaattt ctgctcggcc ataatggttc 841081 cgtaattttg atagactgga gaaccaaaga gcgcgctggc gatttctaaa aattgttttt 841141 gttctaagcc gtatttctcc atcattaaaa aggattcaga taacgcctcc agcatggaca 841201 caagcaagaa attaatgctg attttggctg catttgccgt cttgctttct tcgccgacgt 841261 caaatatctg ctggctcagg ctgtcgagca gaggcttggc agcttgcttt gcttccgccg 841321 gtccggctgt tatgatacgg agcgcggctt tggctgcggc atccggtctg ccaaggacag 841381 gagcggcgag aaaaaattgt cctttctctg catgagccgc tgcgagcttt tctgagaact 841441 caacactgat tgtgctcatc gagatgtgta tgccgttctc tgctaatcct tcaagcagcc 841501 cgtcttctcc gaatgtcacg gtgctgacag aatcatcatc tgcaagcatt gtgatgacaa 841561 tatcagcgga ctttgccgcc agccgcggcg tatcagctgc ctgtgcgcct tctgtgacaa 841621 ggtcttctgt cttttgtttc gtccggttat agacagtcaa ttcgtagcct gcttgaagaa 841681 catttcgggc aatgggctgt cccatattgc cgagtccgat gacagcaatt ttcaatctaa 841741 tcactccctg aatatttttt ccattataaa caatatgaac agaatatgca tagcgatcgg 841801 cttacaacaa aaaagaacag ctgctcgctg tcctcattta aaaatattga accatccttt 841861 atgtacaaac caaatcagca ttccaatcac aagcgcggcc atcaggccaa gtacagcgaa 841921 atatccgtat ttccaatgca gctccggcat aaagtcgaag ttcataccgt atacaccggc 841981 aataaaggtg agcgggatga aaatggttga tacgatcgtc agtgtcatca taatcgcatt 842041 catccggttt gagtttagcg tcacgtagct gtcacgcaag tcggacgtca tgtcacggtt 842101 ggattccaca atttcagaca actttaacaa atgatcatat atgtcgctga aataggcttt 842161 cgtttcccgc tgctctttca catggtcaag gcttaaaatc cggtagagca aatcacgcat 842221 cgggataatc gtccgtctca aatgcaatag gtctgttctg agatcaaaca cctcgttcat 842281 cagcgttcca tacgttttgt ggggacggct ttcttcaatt tcattcagcc ggtcttcaat 842341 tttatacacg agaggaaaat attcatcaac aagctgatcc atgatcatat aagaaatatg 842401 cccgggccct tttttcaata tgtccggtga agcatacaaa cgctcccgga ctttagcgat 842461 accgggcgtt tcgtgtaaat gaaaggtgac gacaaatttt tcgccttgaa agatatcgac 842521 ttcctccgtc tcaagtgttt ccttattcag cgcatgaatc acgtaaaaac gatagccgtc 842581 ataatggtca agctttggcc gctgcatatg ctggaagcaa tcctcaatgg caagcgggtg 842641 aaaatgaaaa aaatctctca ataacgccgt ttccgtatcc tccgggccgt aaaaatcaac 842701 ccagtaccat gcaatatcag gctgttccac tcgttcgatc ggtatatttt tcagcagctg 842761 atgctctgtt gtgattgcgg taatgttgat cataaacaac cctccacctg ccattatatc 842821 atgcggtctt tatgagaaaa gtatacggta ctctctgcct aattccagcg gcatgttata 842881 ctgaacaaaa acggaaaaaa gggtggatct catgtggaag gaaaaagtat ctgtcacgcc 842941 tccgtatcat tttgaccgcg tgctggacag gctgtcttta gaccccctca atgctgttga 843001 tcgagaggcg agggaagtcc gtgtgccaat cagaaatcaa gcgggggacg tatgtattgt 843061 aaaggtacag gcgttaggcc atgcgggcga gcctgagttc ctcgtcagcg gggaaacgga 843121 tcagggagaa atgatgaagg aaatcaagcg gatttttcaa tgggaaaatc atttgcagca 843181 cgttctggat catttttcaa aaacgagcct gtccgccatt tttgaagagc atgccgggac 843241 gccgcttgtt ctggactaca gcgtgtacaa ctgcatgatg aaatgcatta tccaccagca 843301 gcttaatctt tccttcgctt acacgctaac agaacggttt gttcatgcgt ttggcgagca 843361 gaaggatggc gtgtggtgct atccaaagcc ggaaacgatt gcggaactcg attatcagga 843421 tctgcgtgat ctgcaattca gcatgagaaa agcggaatac accattgata catcaaggat 843481 gatcgcagaa ggcacactca gcttgtcaga gctgccgcat atggcggatg aagacattat 843541 gaagaaactg atcaaaatca ggggtatcgg cccgtggacc gtgcaaaacg tcctcatgtt 843601 cggacttggc cgtcccaatt tattcccgct tgccgatatc ggcctccaga atgccatcaa 843661 acgccacttt cagctggacg ataagccggc aaaggatgtc atgctggcga tgagcaagga 843721 gtgggagcct tatttaagct atgcgtcttt gtatttgtgg aggagtatag aataattcgt 843781 ctgacaatga aggaaatcct gcaaacgtgt tatactagaa agatgtgaaa aaaccatttc 843841 actttctgcc atccgcagaa agcttcatat agaaacggag agaacaacgt gaaccaacaa 843901 aagaaacagg cgcccgtcga actgaaggtc ggacaaactt ttccgctgac gattaagcgt 843961 ctcggcatta acggagaagg tgttggctat tttaagaaaa aagtcgtctt cgtgcccggc 844021 gcgcttcctg gcgaagaagt tgttgtgcag gccacaaagg tccagccgaa gttttcggag 844081 ggccgcatta agaaaatccg caaggcatct gagcaccggg tggcaccgcc ttgccctgtt 844141 tatgaacaat gcggcggctg tcagcttcag caccttgcat acagccagca gcttcgggaa 844201 aaacgtgata tcgtcattca gtctcttgaa cgccatacga agtttaaagt tgaaaacatg 844261 gaaatcaaag aaacgattgg catggacaac ccgtggaatt accgcaataa aagccaattc 844321 cagatcgggc gctcgcaaag cggcagcatc atcgccggct tatacggcct tgattctcat 844381 gatatcgtgc cgattaaaga ctgtatcgtt cagcatccgg caacgaacaa aacaacaggc 844441 atcgtccgcc gcattttaga ggacttcaat gtgtctgttt ataatgaaag aaaacgaaaa 844501 ggcgacgttc gcacgatcgt gacgagagtc ggctttgaaa caggcgaagt gcaggtcgtg 844561 cttgtaaccg caaaagaaac gcttccgcac aaggaagaaa tcgtcaaagc gattcaaaag 844621 cgattgccag aggtcaaatc cattattcag aatgtaaacg gggcgaaaac ctcagtgatt 844681 tttggtgaga aaacaaaaca gctcgccgga aaaacagtga ttcaagaagt gctcggcgac 844741 gtatcttttg aattgagcgc ccgcgctttc ttccagctca atccggaaca gaccgtcaag 844801 ctgtatgatg aagtgaaaaa agcggcgcag ctgaccggaa aagaaaaagt cgttgatgcg 844861 tattgcggcg tcggcactat cggcatgtgg gttgcggacg gagcgaagga agtccgcggc 844921 atggacgtca tcaaggaatc aattgacgat gctaagaaaa acgccaaaaa acacggcatg 844981 gcaaatgcca catacgtaac aggaacagcc gagcactggc tcccgaaatg gacgaaagaa 845041 ggcttccgcc cggacgtcgt cattgtagac ccgccaagaa cgggctgtga cagcacgttc 845101 ttggacacga tcaaaaaagt caaaccgaaa cgctttgtct acgtttcctg caatccatcc 845161 acgcttgcga aagatttgca gacgctgtcg aaggactatc gcgtggacta tattcagcct 845221 gtcgatatgt ttccgcagac ggcgcatgtt gaagcagtgg cgaggcttgt attaaaatcg 845281 tctaactaaa aagaacattt cccagtcata aaatagtttt cctaataaga cctggatttc 845341 ggtaaaataa acaattccga tttccgggtc tttttcgtgc gcagctcttg tcctaacggt 845401 ctgttctcaa ttttatcttc cttcttttcg cggagatctt tattttaact ggcgaaaaga 845461 attgaaaaaa cgtgttgaaa agcaggtgaa aaaaagcgtt atttaaccgg aaaaatatcc 845521 tcccagtatg tttaaaatac atgagtagaa tgatgtaaaa tcatagatgt attttcataa 845581 tttgtaaaat tatatattga cttgcagtta ttacgtgtga aatattgatg ataggaatat 845641 aaggaaagta tggcgtatat catttcaaga gtcattcgat gtaaaaagtt gaaacattgt 845701 aataaatgaa agaggtgaaa atgatggcca accccatttt aaaatgcata acgtatgagc 845761 actacaacaa ttaaataata gtgccgagac gataacaact attacagtaa tacctacaat 845821 ggttatatcc ttgcgacaat catgcttcat aatataatga ttttagattg acacttggct 845881 aaaaagtatt gcagagaagg aaatggataa ttaaatggat aaagtatata aaagaagttg 845941 gtttcaaaca tttttggcat ttttagtatc tcagctttat tttaattttg tagaattaac 846001 gggatggggt cctaagtata gagaaatgaa tggattccca gcaaacatag ttgaactaga 846061 tttctttcaa acatatcttt cattctatga taatccatgg tttaatatta ttactgtttt 846121 cttgggagtt ttcactatta tacaaataat tacagggata acaaaggata ttcgaaatta 846181 aagcaataac ttctgatgcc ttatttaatg atgaaagaaa atgtacactt tcttaattat 846241 cttatgagtg aagactgcga cacttagtca gcagtctatt ttatggttct ggatcaggat 846301 taccgaatta taaccctata caaatatata gtaggttgcc acttgctgcg ttggttattt 846361 tctaaatcat gagcaaatcc caaatgattc agattgaagt tcttgaattc ttttaaataa 846421 gggtttattt tctcttctca tcctctttac tccatgtgat tcacaagtgg tagcagctta 846481 agtaggtttt ttcattctct tgagtactca gttataccac ccccaactca atttgcttta 846541 tctctattag tttttccgca aatatgatat agagatacgg atatggtgta gtgttaaata 846601 tcttatcttc aataacaggg caattatttt gcgttggtaa tatggagaac tcatatgata 846661 ttctatttag gttggaatcc tttttatcca aaaagttcaa aagcaaggcc actaagaaag 846721 acgaaggtca gcgccagtta accagaatat aaaaaatagg gtagataatc atcccacgtg 846781 aaatcttcaa aatttactat agattgataa gaaatgcttt cgcatgcgat aagtgtaaaa 846841 gaagcatggt cagtttttaa tttgggataa aggttcagcc gtatcccata atgaaaggat 846901 ttgatttttg ttatgacaga aaatttctgg cgtgaattac cacggccgtt ttttgtactg 846961 gcaccaatgg aagatgtgac agatgttgtt ttccggcatg tagtaagtga agcaggcaga 847021 ccggatgtgt tttttacaga gttcacaaac tcagagagct attgccaccc ggatgggaag 847081 gatagcgtgc gcggccgttt gacttttaca gaggatgaac agccaattgt ggcccatata 847141 tggggagata agcctgaaaa cttccgtaaa atgagtattg gcatggcaga gttaggattt 847201 aaaggactag atatcaatat gggctgccct gtgcctaatg tggcggggaa tggaaaggga 847261 agcggcctta tttgccgtcc tgcagttgcg gcagaattaa tacaagctgc aaaagcaggg 847321 ggattgcctg taagcgtgaa gacaagactt ggatacacgg atgtggatga atggcgcgag 847381 tggctgacac acattttgaa acaggatatt gcgaatcttt ctattcatct gcgtacaagg 847441 gcagaaatga gcaaagtaga tgcgcattgg gagctcatcc cagagattaa gaaacttcgt 847501 gacgaggtgg caccagatac attgctaaca ataaacgggg atattcctga ccgtcaaact 847561 ggcttgaaac ttgctgaaca atacggcgtc gatggaatta tgatagggcg cggtattttt 847621 acaaatcctt tcgcttttga aaaggagccg aaagagcata gcagcaagga attgcttgat 847681 ctcttaaggc tgcatctgga tctccatgat gaatattcaa aagaagaagc ccgtccatac 847741 aagcctcttc ctcgcttttt caagatttat ctccgcggat tccgaggggc aagtgaatta 847801 agaaatcaat gcatgaacac aaagtcaaca gatgaagtgc gtgcattgct cgacgacttt 847861 gagagaaagt atcttgatgg gatagagtaa cagcagtgct tgattcaaaa aaggctaaca 847921 aaataaaggg atttttacac aattcttgac taaaataaac ctggattttc ggtaaatccg 847981 ggtctttttt gtacgcagct tttactcagc ctgtcttttc tctaatttat tgtaagaaaa 848041 taatggtata tttagtggag atatcatata aagggggaga ggaaaatgaa acggctatgc 848101 atcatcccct gcggcaagaa aaaaatctgg gatgtccagc ctgatgccgg gccggtaaga 848161 gcagaggacg cttatctcag cccgtttcat caggcgtgcg agcggtatgc aaaaacattt 848221 ttcgatgagt gggtgatttt gtcggcgaag cacgggttcc tccgccctga tgatctcgtt 848281 tcgggaaatt acgatgtcac ttttggcacc ggtcatccgg aaatcatgac agcggacgag 848341 ctgcgccgtc aatttcacga aaaaggcttt tctgatatcg aagagctagt catgcttggc 848401 ggaaaaaaat atcgaagcgt tctaaacgcc gtcatcggag aacaccagca tatcagctgg 848461 ccgctatcat catacaaagg cataggctat atgctccaag cgctgaaccg ggctgttgaa 848521 gaaaagcatg aactgtagca cgtacatatg aggaaaagag tgggaacatg aaaaaacttg 848581 tgtttggctt gcttgccatt gtgttattcg gatgcggact atatatctat catgtatggt 848641 tcggtgatcc attttcgaaa aatgctgcag aacagaagct agtgtcttat gtgaaacaaa 848701 cctatcctaa gaaagaaatc aagatcacga atggggtata taacgctaaa acgtctgaat 848761 atgtatttga agcaacctcc caatctcatc gctacccaat gtgtacgaag ggatttctgc 848821 atcctaaagt aacgtgcgat ggaattgaag aagcgtatac cgaatcagta gcaaaacatg 848881 taaatgaaga agcaacgaag gcaatcgaag cagatctgaa aaaagcggtt cctcgattta 848941 taaaagctga tgctgctttg agtatcgaaa acggacagtt cacgttagat acaaaatgga 849001 acaaaaagct ggctgaaaaa gcgcctatga gcatgacgat tcagttagac gccagcgggt 849061 tatcaaaaac agatgccgca aagatggcgg aaacggtcag aaaaacgctt aatgaaaagg 849121 gatatacata ctcaaacggc acgatagact gtatgcagaa ggacggggac ggcggtattg 849181 gatatgtcaa atattcaatt gattttcttt caaaagcagc tattcagtca aacgatgcag 849241 aggaactagg aagttaaaaa gatttccaag gaaataaata cgtcgatcat tgtcaaaggc 849301 cgggtgatat ccggtctttt ttttgcatgc tgtaaaacga gacaaatgaa tcagtttgag 849361 acaaaacgag acacacgtct caaactgtct ccaaagtgaa gatgagaaga ctgattttac 849421 gggctcaaaa gactggcaca cttcttgcat ttataatggt gaaccctaaa tagaaggagg 849481 cgcacaaaat gaaattgtta aaacgagaag gcttgtcatt aactgaggaa aaagcgctgt 849541 ggatgtacca aaagatgctg gagatcaggg gctttgaaga caaagtgcat gaactgttcg 849601 cccagggagt gcttcccgga ttcgttcatt tatatgccgg tgaggaagcc gtggctgtag 849661 gggtgtgcgc tcatttacat gatggcgaca gcattacaag cacccacagg ggacatggac 849721 attgtatcgc caaaggctgt gacctggacg gcatgatggc ggaaattttc gggaaagcga 849781 ccggattgtg caaaggcaag ggcggttcta tgcacattgc ggatcttgat aaaggcatgt 849841 taggcgcaaa tggaatcgtc gggggcggct ttacgctcgc atgcggatca gcgctcacgg 849901 ctaaatataa acagactaaa aatgtaagcg tttgcttttt cggggacggg gcaaataacc 849961 aaggtacctt ccacgaaggg ctgaatttag cggctgtatg gaaccttcct gtcgtatttg 850021 ttgctgaaaa caacggctat ggcgaagcta ccccatttga gtacgcatca gcctgtgatt 850081 caatcgccga tcgggcggct gcttataaca tgccgggggt tacagttgac ggcaaagata 850141 ttttagcagt ttaccaggca gccgaggaag cgatagaaag agcaagaaac ggcggcggcc 850201 cgtctttgat tgaatgtatg acctacagaa actacggcca tttcgaagga gatgcccaaa 850261 cctataaaac gaaggatgaa agagttgagc accttgaaga aaaagatgcc attcaaggtt 850321 ttaaaaacta ccttttaaaa gaaacagatg ctaataagct gtcagacatt gaacagcgtg 850381 tcagcgaatc gattgaaaaa gccgtctcgt tcagcgaaga cagcccatat ccaaaagatt 850441 cggagctgct gacagatgtg tatgtgtcat atgaaaaagg aggaatgtaa gagatggcga 850501 gagtcataag catgtcagac gcgatcaatg aagcaatgaa gcttgcgatg agaaaagacg 850561 aaaatgtgct tttgatcggt gaggatgtcg ccgggggagc ggcggtcgat catttgcagg 850621 atgatgaagc atggggcggt gtattagggg tcacaaaggg actcgtacag gaattcgggc 850681 gtacaagagt gctggacact ccgatttctg aggcaggcta tatgggagcg gctatggctg 850741 cggcatcaac cggtttgaga ccgattgccg agctgatgtt taacgatttt atcggcacgt 850801 gctttgatca ggtgatcaac caaggggcga aattccgtta tatgttcggc ggaaaagcgc 850861 aagtgccgat taccgtccgc accacatacg gagcagggtt ccgggccgct gcccagcatt 850921 cacaatcgct gtatggcctt ttcacgagca tccctggact gaagacagtt gttccatcca 850981 atccgtatga tgccaaaggt cttttgcttg cagcaataga agataatgat ccggtgtttt 851041 tctttgaaga caaaacgtcc tacaacatga agggcgaggt gccggaagat tattatacaa 851101 ttcccctcgg aaaagcggat atcaaacgcg aaggcaatga tgttacgctc tttgcagtcg 851161 gcaagcaggt caatactgcg cttgaagcgg ctgcacagct ttcagagagg ggcatcgaag 851221 ccgaggtcct tgatccccgc agtctgtctc ctctggatga ggatgcgatt ttcacatcgt 851281 tagaaaaaac aaaccggctg atcatcattg atgaagccaa tccgcgatgc agcattgcca 851341 cggatattgc tgcgcttgtc gctgacaagg gctttgattt gcttgatgcg ccgattaaac 851401 ggattacagc gccgcataca ccggttccgt tttcaccagt gcttgaagat caatatttgc 851461 cgacaccaga taaaattgtc agcgtcacgc ttgaattgct tggcgagccg gcattgaatt 851521 aaagggggga cacaaatggc ggtaaaagta gtgatgccaa aattgggaat ggccatgaaa 851581 caaggggaag tatcgatatg gaataaaaaa gtaggcgacc cggttgaaaa gggagaaagc 851641 attgccagca ttcaatcgga gaaaattgaa atggagatcg aagcgcctga aaaaggaacg 851701 ctgatcgata tcaaagtgaa agagggagaa gaggttccgc ccggcacagc tatctgctat 851761 atcggggacg ccaatgagtc ggtgcaggaa gaggcggggg cgcctgttgc tgaagacaat 851821 atgccgcaag ccgtccagcc cgtcaaacaa gaaaacaaac ccgcagcctc caaaaaagat 851881 cgaatgaaaa tatctccagt cgccaggaaa atagcagaaa aagcaggatt agacctaaaa 851941 caactgaaag gaactggacc aggcggacga atcgtgaagg atgacgtaac aaaggctctt 852001 gctgaacaga aaaaagatca agcaaagcct gtttcggagc agaaagcgca ggaaatcccg 852061 gtgacaggca tgagaaaggt catcgctgcc cgaatgcagg aaagcctggc aaacagcgcg 852121 cagctgacga tcacgatgaa agctgatatc accaagcttg ccactcttca aaaacagctt 852181 tcaccaactg cggaagagag atacggcaca aaactgacga tcactcattt tgtctcaaga 852241 gccgccgttc tcgctctgca agctcaccct gtgctgaaca gcttttatca aaatgagcgc 852301 atcatcacac atccccatgt gcaccttggt atggctgtag ccttggaaaa tggcttagtg 852361 gtgcctgtca tccgccatgc tgaaaagcta tcgctgattg aactggctca atccatctca 852421 gaaaatgcca aaaaagcacg cgagggacgt gcgggaagcg aagaactgca aggatctact 852481 ttctccatta caaaccttgg cgcgtttgga gttgagcatt tcacaccgat actaaatccg 852541 ccggaaacag gcattctcgg catcggagca agctatgaca caccggtgta tcaaggggag 852601 gagatcgtca gaagcacgat cctgccactc agcctgacat ttgatcacag agcgtgtgac 852661 ggcgcccctg ccgctgcatt cctgaaggcg atgaaaacat atttggaaga acccgcagca 852721 ttaattttat aggaaaagca ggtgaaaacg acatgacatt agccattatc ggcggcggac 852781 ctgcaggcta tgcggctgcg gtttccgcgg cacagcaggg cagaaacgtg ctgctcattg 852841 acaaaggcaa gcttgggggg acctgcctga atgaaggctg catcccgaca aagtctttgt 852901 tagaaagcgc aaacgttctt gataaaatca agcatgccga cagctttgga atcgaacttc 852961 cggcaggtgc gatatcagtc gattggagta aaatgcaaag ccgaaaacaa caggttgtca 853021 gtcagcttgt ccaaggcgtt cagtacctaa tgaagaaaaa tcaaatacag gttgtaaagg 853081 gaacagcctc ctttctttct gaaagaaagc tcttgatcga aggagaaaac ggaaaagaaa 853141 tcagagaggc ggaccaagta ttgattgcct ccgggtcaga gccaatcgag ctgccttttg 853201 ccccatttga cggcgaatgg atcctcgaca gcaaagacgc gctttctctt tccgagattc 853261 cgtcttcact agtcattgtc ggcggcggtg tcatcgggtg tgagtatgca gggctgttcg 853321 ccagattggg atcgcaggtg accatcattg aaacagcgga ccggctgatc ccggctgaag 853381 atgaagatat tgcccgtctc tttcaggaga aacttgagga agacggtgtc gaagtgcata 853441 cttcatccag attagggcgg gtggatcaaa cggccaaaac ggcaatatgg aaaagcggtc 853501 agcgagagtt taaaacgaag gccgattatg tgctggtggc gatcggcaga aaaccccgtc 853561 ttgacggatt gcagctggaa caggccggag ttgatttttc tccaaagggc attccggtga 853621 atgggcacat gcagacgaac gtgcctcata tttacgcgtg cggagatgct atagggggca 853681 ttcagctcgc gcatgccgct ttccatgagg gcatcatcgc tgcttctcat gcttccggaa 853741 gggatgtcaa aatcaatgag aaacatgtgc cgcgctgcat ctatacgtcc ccggaaatcg 853801 cgtgtatcgg aatgacagaa cgacaggcaa gaagcatata cggggatgtg aagatcggcg 853861 aattttcatt ttccgcaaac ggcaaggcgc tcattaaaca gcaagcggaa ggaaaggtca 853921 aaatcatggc tgaaccggaa ttcggcgaaa tcgtgggtgt ctcgatgatt ggcccggatg 853981 taaccgagct catcggccaa gcggcagcga tcatgaatgg tgagatgacg gcagatatgg 854041 cggagcattt tatcgccgcc catccgactt tatcggaaac attgcatgag gcgctgttaa 854101 gcacgatcgg ccttgcggta catgcataat aaaggaaaaa gcaggcgcat ggatataagg 854161 cgcctgcttt tttattgttg aaagcgcttt atttttcccc tacaatagat gaaaacggcg 854221 tgtaagggag gagcgatcaa ggaaatgaat tcggtcccaa acgatttgca aacctggaaa 854281 cgttttgtga aagacggtgt gcttgacgaa gcccgattaa gaaaacggat tgcagagtca 854341 tggcatcgct gcaaaaaagc tgaggtcaat ccttatttag aaaaaggccc gaaggtttta 854401 cagcaaacgg agctggatca gcagtcaaaa aaacattcat tcttcttgac gaccgcaaag 854461 ccttacctcg aaaaactgct gcctgccata aaagaaatgg aaatgatggc gctgttaatt 854521 gattcagacg gtgttgttct ggcattggac ggccatccgc gcgcgctcta tgaagccaaa 854581 cgcatcaatt tcgtcgaagg ggcatgctgg acagaaacgg ctgtcggaac aaatgcgatt 854641 ggcacggcgc tccacatcag cgagccggtt gcaatacaag gatcagagca ttactctatc 854701 gcttcccatc tttggaactg ttcagctgct ccgattcacc atgaggatgg cagccttgcg 854761 ggtgtaattg acatatcatg cccggcggca ggcgcgcatc ctcatatgct tggtattgcc 854821 acggcgattg cctatgccgc tgaacgggaa ctcgcagcta aaagccgtga gaaagagctg 854881 gagctgatca gccgttttgg ggagagagct gcatccagtg tgccgatggt gctctgtaat 854941 accaagcagc acatcatcag tgcgagcatg ccgattcgaa cctcaatgcc ggattggcag 855001 ggccggcacc tgtacgagtt gaaggaacgg ggctattcaa tcgaaaatgc tgtcaccata 855061 ggagatggcg gcacttgttt ttatctttcg gaacaaaaga aaaagaaggc gtttcgattc 855121 aatggagtga tcgggcaaag cggccgatcg caagcgatgc tgatgcacct tgaacgagca 855181 gctgcgacgg atgcatcggt ctgtttgtcg ggtgaaacgg gtacggggaa ggaggtcgcg 855241 gctcgcgcgc ttcatgagaa cagtgagaga cggcacggtc cgtttgttgc tgtcaattgc 855301 ggagcgattc cgtctgattt gattgaaagc gaactgttcg gatatgcaga gggcgctttt 855361 acgggagcga aacgaaatgg ctataaaggc gcctttcaaa aagcgaatca aggcacatta 855421 tttttagatg aaatcggaga aatttcccac tcgatgcagg ttgcactttt acgggtgctt 855481 caggaacgca agataacgcc aatcggcggg acgaaagaaa ttccggttga tatcagagtt 855541 attgccgcca cacattgtga tttacgcgag cttgccgaaa acggaaaaat cagagaggac 855601 ttgttttacc gtcttcatgt ctatccaatt gaactccctc cattacgcga tcgcaccgag 855661 gatatcccgg atctctttga gtactacaaa cagaagaatc attggccagg cgatcttcct 855721 tctgattttt gtaatgtgct gaagcaatgg aagtggccgg ggaatatccg cgagctgttt 855781 aatgtgtttg aacgtctttc tatcagattt ccggacggcc ggctgagaga tgaatcgctt 855841 cccgctttac tggaagccgc tggattgccg gccagctctg cagaaaaaaa gccggctgct 855901 gccggcgtgc ttacttttcg tgagcaaatc caaaaggata tgatgatcaa agcgcttgaa 855961 tctgcaaaag gaaacgtctc tcaagccgca aaaatcagcg ggatcccccg aagcactttc 856021 tacaaacgcc tgaaaaaatt caacttgtcc gctgaatcat aaagcatact tccttcagga 856081 aatggaaacg ttatgtattg aaggagggtg ttacgatgaa tattcaaagg gcgaaagaaa 856141 ttgtagaatc tcccgacatg aagaaagtaa catataacgg cgttcctatt tacattcagc 856201 acgtaaatga agaaactgga acagcaagaa tttatccgct tgacgaaccg caagaggagc 856261 atgaagtgca gctgaacagc ttaaaagagg attaaacaaa aatggcccgc ttcataagca 856321 ggccattttg ttatccgcgc ggcgcaaata aaataacaca gacaccgatg agacaaatga 856381 atgcgccgat ccagtcatac agatcaggtg ttttccggtc aacaagccat ccccacagga 856441 ccgcaagcac gatgaatact ccgccataag cggcgtatac acggccgaaa gatgggaagg 856501 actgaaacgt cggaagaatg ccgtatacaa tgaggatcag cgccccggcg attccgtagc 856561 cagctggctt tgcctctctc agccatagcc aaaccagata tccgccgcca atttcagcaa 856621 gccctgccgc gagaaataaa agaatggtaa tcagcatcat gagcactcct caatttgcat 856681 ttatctttca ttatagagga ggagagcttt taaagcttcg gatgattctc aaattccttc 856741 aaatacgctt ttcgctgaac ctctgtaaat tggctgatcc aattgttttg agcctcttca 856801 ttcaaatggg gaaggatata gcgttcaacc gcttcgaaaa acagcggatt cgtgatgatg 856861 ttccaggtcg ggattcgaac gattttgccg tctgttttct cgatgataat atcctcaaaa 856921 aagatccctt tcaaactgta ttgatggcgt cccatataaa gccgcttcac ctcggaaaac 856981 agcacgctgc gctttctcaa gaagatttcg ccactaggtc cggtctttat ggtgaaaatg 857041 acatttccac ggcttgtgaa cgcaggaaaa gccataaaga atgtgatcaa tccataaatc 857101 atcgccagta atccgccgcc caaataaagc agggcatatt tagattcaaa cgtgagggct 857161 tcagacacca gccagactcc cacaataaag gcgccccctg tagcgaggaa cagccaagcc 857221 cttagaaaca tcatgctttt tacttcaatc atgtgctgcc cctaaagctt cggatgattc 857281 tcaaattcct tcaaatacgc actgcgttgg atgtctgtaa actgtccgat ccaattgctt 857341 ttcgcctctt cattcagatg tggaaggata tagcgttcaa ccgcttcgaa aaacaacgga 857401 ttcggaatga tgttccaagt gggaatgcga atggtcttct gatccacggt ttggatcaat 857461 atatcttctt ggaagattcc ttttagacta aatttatggc ggctcatctc aattttcttg 857521 atatcagtaa acgtaacaga cactttgtca gtgaacactt ctccattttt tcctgtcttg 857581 atgcggaaaa tggtatttcc ccgcggggtg aaagccggaa agaagatgat aaataaatat 857641 aaacaaaaca aggtgaacag aaagccagca ggaatggcta ataggtaata tttcgtttga 857701 aacgtaatac ccatataaaa gagccacaaa catgctaatc ccataccggc agatccgaca 857761 aaagcccata ttctcaggaa cattttgctt ttgacttcaa tgatttcttg gtttttcaat 857821 gcttttctcc ttttgttaat tcaattctta tcattttgaa atgatttgat ttacaacatc 857881 cttatgagca gggaggatag aaaattcatt ctgggtgatg cctgtgacaa gccaagtatg 857941 gtgggccccc ggcaggacga atgccatgtc agccacttca ggagtgttat cttttccata 858001 tgccagacgc ataagtgtat ccattttccc tttccgcaaa gccagatcat ttgcaaatcg 858061 ggtaacgtcc tcttggtggt catgtttttc aaggaactct tttagatatg aagggttgtc 858121 tgaagcgccc tccaagagtt tttcaaattc atttgatgtc aatgttacaa tcgattctct 858181 tttatcctct gtatctatta tatgtaaaaa ctcatctgtc ttagcaagta acccttcact 858241 tgattccatt tttgtaatgc gatggacttg ttcatcaaaa aggagttcgt gagagtaggt 858301 gccgaatttt gatacatggc atgacacatt ctgttcggca ccttgcccgt taaatttaga 858361 aagcttcact gtatagtcag cgtcgtttaa tacatggata aacggacagt actcgtcctt 858421 taaccgatat tgatggttcc gatattccgc tgcatccttg gctaagagtg agcggcacgc 858481 ggcttcaaat aaggcgccga gctgttcatc ttctatttcc ggaaaatagg cctgcttcaa 858541 ggccattccc tgttcaaaaa acccttcgct gtaaaagcaa aacaagagtt cttctatgct 858601 aattgtaaac tgcttcattg tttattctcc tatccaaatg aaaatttccc tttaaggaaa 858661 tgggttgcgc cgtgtataag cgaatccgct gttttctttg ctttttccat tccttttttc 858721 gcgctgtcta tccctttatg tatcgattta ttcgccgcat ctatgccgtc attcactgat 858781 ttgacgactt tgccggctga ttccagccct tttttggctg tatcaacaac agcatggatc 858841 ggttctttca gctttaaggc tgctttttca gcaaaaccgg ctgtatattt ggcgatttgt 858901 tctccgacga ctccgccaat gtatgaacct gctgccccaa gaaggacagt acccacaggt 858961 cctgcaaagc ttccgattgc accgccgatg acagcaccag ctgtggcacc gccggcaaca 859021 aaaatcgtat tattcacagc attcccgacg gccttggcgt tttcacgctt gagaacttcc 859081 ggtttatcct ggtattttgc ataattttca gcaattttca cgcctgctcc gaatgtttcg 859141 gtcgctccgg taatcagtgt ggcggtaatg gcatttcctt tcgcgaatct caagcccgtt 859201 tttcccacat ccttcaaagt ggagcgtacg ccggcttcat taagaaatcc ttttgtgtag 859261 cttctgacgc tgtttgaaaa atccaccgtg tcctgaggaa agtattttgt aaacttttta 859321 tgtaccaaat ctgaaaatgg acggtttgtc tttttcaaca aatatttagg attcaaaagc 859381 actcttgccg ctttttgata acgtgagctg tcaacggccc tggaaatatc caagagcagt 859441 tttgagtgct gggctgtatg caagccgctt ggttgtttca caaatttcgt aagccctaat 859501 ccgtaatatt ttccctgcgt cagcataaga gcggttaagc ttgtcatcgt accgtatttg 859561 tcgtaggcat tgtagagctt tcgcaaaata tcatcttgtt ccacaaattt atcgcctgtt 859621 tttctgatga aaatctcatt gtcactcagc ttagtgacga gcgcctttcc tgagctccac 859681 gcatcgccca ctccagaaaa acagctgctg tagcggggat cgcattgcaa aatcatctgc 859741 cccagctcca catgcaggtc cttatatttg ttttccatat cagttaattc agtgactaca 859801 tcatttgcaa gctgttcgag cttatccgga tcaactgcaa tgtttcctga cacaccgttc 859861 acctcccgag tttatgtctt tcctctcttg ctttacgctc cagttcttcc attctggcaa 859921 tttcagcttt tcgttcttct attttgacag cggcagcctt cagctcttgg cttgtttcaa 859981 gcagctcctg ttcgaattga tcgtaggcgg ctttcgtttc ctcgaaatcc tggtcaaacg 860041 aatctcttgc tttgccctgc caagcatctc ccaatgcaga taaccgggat tcaagcagca 860101 ttttggagct tctgacctct tctgcggccg cactatactt gtttgccagc tcaatgactt 860161 tatatgagtc caacttttgt cccctgcctt ttctaaattc acgcacaatt ggatgtttta 860221 tataaatgat tataaataat tcggcatgta tccgaatcgt acaaaagaac cttttcataa 860281 gaattggaag ggcgtatatt cacttaaaat tcacagttgg tgagacttta agattacaaa 860341 aaaggtaaaa aaaccaaatc tctcagacat aaggcaaatg agaaatttcc cgctctatgg 860401 gaaaaaacac taaagttgat caaatgacct aagtgcgcca aacgtgttac gggacgagct 860461 atctcatggt ataaatggaa ttgtaaacgt tatcaaggag gtcgtcatat gaagaaaaaa 860521 tcattctcaa tcgtaatagc gggcggaggg agcactttca ctccagggat cgtactcatg 860581 ctcttggacc atttggagga gtttccgatc agaaagctga agctgtatga taatgataag 860641 gagagacagg atcgaattgc aggcgcctgt gacgttttta tcagagaaaa agcgccggat 860701 attgaatttg cagcgacgac tgacccggaa gaagctttta cagatgtcga ttttgttatg 860761 gcgcacatca gagtagggaa atacgcgatg cgcgcgcttg atgagcaaat tccgttaaag 860821 tacggagttg tcggccagga gacgtgcggg ccgggcggga tcgcatacgg tatgcgttcg 860881 atcggcggtg tgcttgaaat attagattac atggaaaaat actcgcctga tgcgtggatg 860941 ctcaattatt ccaatccggc ggcaattgtg gctgaagcta cgagacgcct tagaccgaat 861001 tctaaaattc tcaatatctg tgatatgccg gttgggatcg aagaccggat ggcgcaaatt 861061 cttggcttat cctcaagaaa agaaatgaag gtccgctatt acggattgaa tcatttcggc 861121 tggtggacat cgattcagga tcaagagggc aacgatttaa tgccgaagct gaaggaacat 861181 gtatcccaat acggttatat tccgaaaaca gaggctgaag ctgtggaggc aagctggaat 861241 gacacgttcg ccaaagcgcg tgacgtgcag gctgcagatc ctgacacact gccgaatacg 861301 tatttgcaat attatttgtt cccagatgat atggtgaaaa aatcaaatcc gaatcatacg 861361 cgggcgaatg aagtcatgga agggcgcgaa gcttttattt tcagccaatg tgacatgatc 861421 acacgtgaac agtcctcgga aaacagcgaa attaaaatcg atgaccacgc atcgtatatc 861481 gttgatcttg cccgggcgat tgcctacaac acaggtgaaa gaatgctgtt gattgttgaa 861541 aataacggtg caattgcgaa ctttgacccg actgcgatgg ttgaggtgcc atgcatcgtc 861601 ggctcaaatg gacctgaacc gattaccgtt ggcaccattc cgcaattcca gaaagggctc 861661 atggagcagc aggtatccgt tgagaagctg actgttgaag cgtgggcaga gaaatcgttc 861721 caaaagctgt ggcaggcgct gatcctgtca aaaacagtgc cgaacgcgcg tgtggcaaga 861781 ctcattcttg aggatttagt ggaggccaac aaagacttct ggcctgagct tgatcaaagc 861841 ccaacccgca tatcataaat gaaattcccc cattttcgaa tctgtaattg tatataatag 861901 aaagaaaatg gggggatctg atatgcagct cgaagaactg atcaatcagc actacagcaa 861961 attgaatgac aacgattttc atattttaaa atatatattg aatcataagc acacatgcta 862021 tcaccttgga atcgacgcgc tggccaaagc ttgcagtgta tcgcgttcct caattttacg 862081 gcttgcccaa aagctcggtt tcagcggtta cagtgaattt cgcgtctttt taaagtggga 862141 agatcagccg gaagaaggcg agagtatgag ttttgaaaag ctgcttgatg atattgaagc 862201 aaatttgaag tttttacgga caaaggacat gacggacatg tgccagctga ttgatgcagc 862261 tgaccgcatt ttcgtctacg gttctggaaa tgcgcaaaag atatgcgccc gcgacctgca 862321 aagaatgttt attccgcgcc atcgctatct tattttgatt gaagacacaa atgaatttaa 862381 tttgatgcgc gatgatttta aagtgaacga tctgtttatc atcatttctc tttccggaga 862441 aacaccggag ctgattcctc aggcaagaat gctttctgca aagggtattc cctttatttc 862501 cattacgaat ttaaaaaaca atgtcctcgc ccagctgact ccgcataatc tttatgcgac 862561 aagcaaacct gtgacattaa gcgatagaac ggaaattgtc gcttttgcac cgttttttct 862621 cgttggcgaa gcattgttcc gcgcatatgt tgattacaaa gaggcagaaa aaaatgacaa 862681 tgagtagcag ggggttctgg tatgatgcaa aaaattcagc gctttggaag cgcgatgttt 862741 gtgcctgttt tattattcgc gttcgccggc attatcgtcg gtatcagcac gctctttaaa 862801 aataaaaccc tcatgggacc gctcgccgat cctgacggtt tttggtatca gtgctggtat 862861 atcattgagc agggcggctg gactgttttt aaccaaatgc cgctcttatt cgccattggc 862921 atcccggttg ctttggcgaa gaaagctcag gcacgcgcct gtttggaagc gcttactgtc 862981 tacctgacat tcaactattt tgtcagcgcg atattgacgg tatggggagg agcatttggc 863041 gtcgacatga atcaagaggt cggcggaacg agcgggttaa cgatgattgc gggcataaaa 863101 acgctcgata ccaacatcat cggagccatc tttatttctt cgattgtcgt ctttttgcat 863161 aatcgctatt ttgataaaaa actgcccgat tttctcggca tctttcaagg ctcaacatat 863221 atcgtgatga tttccttctt tattatgatc ccaattgcgt tggctgtgtc ttatatttgg 863281 ccgatggttc aatcgggaat cggctcgctt caaagcttcc tggttgcttc tggggcggtg 863341 ggcgtttgga tatacacgtt tttggaacgg attttaattc cgaccggcct tcatcacttt 863401 atttacacgc cgtttattta tggcccggct gtagcggaag gcgggatcgt cacgtattgg 863461 gcacagcatc tcggcgaata ttcgcaaagc gccaaaccgc tgaaggagct ctttccgcaa 863521 ggcggattcg cgcttcacgg caactcgaaa atcttcggta ttccgggtat cgccctggct 863581 ttttatgtga cagccaaaaa ggaaaagaaa aaactcgtcg cagggctgct gattcctgtc 863641 acactgacag cgattgtcgc cggtattaca gagccgattg agtttacgtt cttattcatt 863701 tcacctttct tatttgcggt tcacgccgtg cttgccgcca caatgtcgac agttatgtat 863761 atggccggcg tcgtcggaaa tatgggaggc ggactgattg aggcggtaac cttgaactgg 863821 attccgctct ttggcagcca cggtatgaca tatgtgtatc aaattttgat cgggctctcg 863881 tttacagcaa tttatttttt cgtcttcaga tttttaatcc tcaaattcaa tatcgctaca 863941 ccaggacggg aaaaggatga acagcaggaa acaaagctat attcgaaaaa ggaatacaga 864001 gaacgaaaaa acaaggatga aacggcctcc gctgctgaaa cggctgatga caccgctttt 864061 ctgtatattg aagcgctggg cggaaaagac aacatcactg aagtcacaaa ctgcgccacc 864121 cgcctcagag tcagtgtcaa ggatgaaaca aaggttgaac ccgacagcgt attccgcgcg 864181 cttggcgcac acggcgttgt caggaacggg aaggcgtttc aggtaattat cggattaagc 864241 gtgccgcaga tgcgggagcg tgtggaaaaa atattgaatc aataaagact gccctccttt 864301 tcgggagggt tttcgtttgc cgtcaaaaag accgccatag taaagtaaag aaagagacaa 864361 tcgagtaaaa aggggtttgg aggcttttac atgcaaaagg ctttgtcgtt tttaaaacca 864421 tattcattgc tggcgggaat tgctctgatt cttatgctga cggagcttgc agttgaactg 864481 atgcagcctt tattgattgc aaaaatcatc gacgatggga tattgaagca agatctgcgg 864541 catgtatgga tatggggcac ggtcatgatc gggctgaccg tgttatcctt tgcggcgggg 864601 atgctgaatt ccttttatgc cgcccatgtc agccaaagct tttcctatga tacgagaaaa 864661 gggctttttc aaaaaatcca gtccttctcc tattccacat ttggacagtt ttcgtcctct 864721 tcttatatta caaggctgac aaacgacgtc acacaggttc aaaatatgat ttttatgagt 864781 ttgcggttta tgctgcgggc tcccttaatg attgcaggcg gcattgtgct gtcgcttgcc 864841 gttaatgtga aactcgggtt ttttctgctt gtgaccattc cgatcctgat cttgtttttg 864901 ctatgggtat taaggaaagg cggggcactg ttccgctcag tgcagaaaag gctggatcaa 864961 gtgaacacca tcatgcagga aaatttaatt gcaatcaagc tgatcaaagc gctgcttcgc 865021 ggcagccacg aagtcaaacg atttatcaaa gccaacacaa ggctgatgga aaaaacggtt 865081 tcggcctttc agcttgtgga attcacgatg cctgtactga tgctgctgat gaatctctgc 865141 atccttttga ttttgtgggc ggggtcctac agtattacga gcggaagcac tcaggttggc 865201 gatgttgttg cgataattaa ctacgcaaca cgaattacag gcgcgctttc gatgtttccg 865261 tttttgatta tgattttcac ccgggcgaag gcttcagggg atagaatcgg tgaggtgctt 865321 gaaacagaag gcgacgagcg ggaggaaggc accatatctg atcgtttgtc aggacggatt 865381 gagtttcagc atgtatcctt tcgctatcct gaaatggaca gagaagcgct caggaatgtc 865441 tcattttccg caaagccaag agaaacgatc gcgattctcg gtgcgacggg ctcgggcaag 865501 tccacgcttt ttcagctcat tccgcggctt tatcagccgg attcaggccg catttacata 865561 gatgaaaagc cggttcaaga tattccggct gaagggctgc gcaggcaaat tggatatgta 865621 ccgcaggaag tcctcttgtt ttccggcaca atcaaagaaa acatcgcttg gggcaaagaa 865681 aatgcttcac tagatgaaat aatggatgcg gcaaaacttg cgcaaattca tgaaacgatt 865741 ttaaagctcc caaatggata tgacactgtt ttggggcaaa gaggcgtcaa cctgtccggc 865801 ggccaaaagc agcggatttc cattgcgcgg gcgctgattc gaaaaccggc tatccttcta 865861 ttagatgaca gcacaagcgc gcttgatctg caaacggagg cgaagctgct tgaagcaatc 865921 agcacatacc attgcacaac tttgatcatt acacaaaaaa taaccacggc gatgaaagct 865981 gatcagattt tgctgcttga ggacggcgaa ctgattgaaa aaggcactca cagtgagctg 866041 ctttctgaat ctcagttata caagcgcatt tacgagtcac aattcggaag ggaggggagc 866101 gagtcatgct aaaagacatc cgcaagcctt tccaatatcc caaactgcca attgacaaaa 866161 aagaaggcgc gaaaaagcgg gcgaaagcaa aggatacaaa gggcacactg agacgaatct 866221 ggtcttactt ggctgaaaga aaaggactgc tcatacttgt catgctaatg gttgtcatca 866281 gcgccatatt cggactcctt ggtccctttg tgatcggaaa ggccatcgac cattttatcg 866341 tcgggaaaac ggtcagcggc ttgattcctg ttttgcttct tctgctcgct atctatatca 866401 ttcagtccct gtcgctttgg tttcaaaact attggatgat tacgatctcg cagggcacgg 866461 ttttcagaat gagaagcgaa ttgttcaccc atctgcatga gctgccgatt ccattttttg 866521 ataaacagcg gcacggcgag ctgatgagcc gggtgacgaa tgacatcgaa aatgtcagtt 866581 ctaccttaaa cacgtcagtc attcaaattt tgtcaagtgt gatcaccttt gtcgggacga 866641 ttgcggtgat gctgtacatg agcccgctcc ttactttgat tacgctgacc attattccgg 866701 tgatggcagc gagcctgaaa tggatcacca accgaacggg aaagctgttt aaagaacagc 866761 agaaaaacct tggtgatctg aatgggtata ttgaggaatc tgtttcaggc gcaaaggtca 866821 tcaaagcata ttcacgtgag aagcagatta ctgctgaatt cctcgaaaaa aacgctgcac 866881 tcaagacgtc gggcttttgg gcgcagacga tttccgggtt tattccgaag gtcatgaact 866941 ctttgaataa cttaagcttt acaatgattg cggcaatcgg cggtttgttt gcgctgaaag 867001 gctggatctc gatcggctcc atcgttgtct ttgccgagta ttcaagacaa tttacacgcc 867061 ctttaaacga tctggccaac cagtttaata cgatgctgtc cgcaatcgcc ggcgctgaac 867121 gggtgtttga cgtgcttgat gaaaaagaag agcgcgagga tgaaaagaac gccgtgcatc 867181 agcccatcca aacaggcagc attgaattcc gggatgtgtc cttcggttac gataaagggc 867241 agcagacact gaagcattta cagtttaccg tgcctgcggg gcagtccatc gcgtttgtag 867301 gaccgacggg ggcggggaag acaaccgtca ctaaccttct cgcccgtttt tacgagccta 867361 acgatggaaa aattttaatc gatggtacag atattaaaac ccttactaga gcaagcctaa 867421 gaaaaaacat ggggtttgtt cttcaggatt ctttcttatt tcagggaacg atcagagaaa 867481 acattcgcta cggcaggctt gatgcttctg atcaggaagt cgaagccgct gcaaaaacag 867541 cgaatgccca tagttttatt gaaaggctgc caaaagggta tgacaccgta ctgacgcaaa 867601 acggttcggg catcagtcaa gggcagaagc agttgatttc tatagcgagg gcggtgcttg 867661 ccgatccggt tcttctcatt ttggatgaag cgacaagcaa cattgatacc gttacagaag 867721 tcaacattca agaagcgctc gcccgtttaa tggaaggaag aacaagcgtc atcattgccc 867781 acaggctgaa caccattcaa agagcggacc agattgtggt gctaaaaaac ggtgaaatga 867841 ttgaaaaagg cagccatgac gagctgattc ggcaaaaagg attttacagt gacttatatg 867901 aaagccaatt tgagaaatag acctttgtcc tgcacagagg tctttttttg ttacagtttt 867961 atagtacttt tatttcattt tcgtaaaatg taacaaaatt acttgacgta aacaagttat 868021 gtatatatac tagcttacat taagtaagtg ataacattta tcaaggagga taaaatgaat 868081 aaatcatttg aaattggcac attactttta agagttatta caggtattat cttttttgtt 868141 cacggtttat caaagtttca gggaatggag ggcaccatcc aatttttcgg cagcataggc 868201 cttccaagct ttatggcgta tgtcatcgca gcgattgaac tgattggcgg agtgcttgtc 868261 ttcttcggat tggctacacg tattgtcggt gtactgttcg ctcttacact gatcggcgcc 868321 atcatcactg ttaagctgaa agcgccattc atgggcaatg cagaatttga ttaccttctg 868381 cttttgacat ccattcacct ggcgcttact ggaagtcgat tcctggcgct ggacccattt 868441 gtgtttaaag gaaaaaagaa cggaaacgtt tcagcataag aaaagaggca tgcagcatga 868501 ccagcattca tgaggataca cacattggct atgccaaact cacaattcgc agtctggagc 868561 gttcgcttca gttctactgt aacgtcatcg gttttcaagt cttaaaaaag acggaccgcc 868621 aagcggaatt aacggctgac gggaaacgcg tactgcttat tcttgaagaa aatccgagcg 868681 ctgtcgtctt gcctgaacgg tctgtgacag gcctttatca ctttgcgatt cttcttccgg 868741 acaggaaaga acttgggatc gcgctcgccc gcctgattga acacggcatt gctatcggac 868801 atggagacca tgctgtcagc gaagcgctct acctgtctga tcctgacgga aacggcattg 868861 aaatgtacgc tgaccgcccc cgcagcacgt ggcagcgtga tcgggaagga aactacgtca 868921 tgacgacaac cgctgttgac attgagggcc ttctggaaga ggcaggagat gagcggaaaa 868981 catcgcttcc gaacgataca atcatcggac acattcatct gcatgtcagt gatttgaaag 869041 aagcaaaggc gttttataca gatgtactgg gctttgacat tgtcggaaac tatgcgggca 869101 tgtccgccct cttcgtttca gccggggggt accaccatca tatcggctta aacatttggg 869161 cgggaagaaa tgcgccgcct aaaccgacaa atgccagcgg actagattat tatactgttg 869221 tcctgcccca ccaagaggag ctggatttgg tggcaaaccg agtcaaacat gccgggtatt 869281 cgattgaaga gacggaaaac agctttcgtg tgaaagaccc tgtttccggc gcctatatta 869341 catttgtgat ttaactgcaa tccccttgcc gaaataacgg cagggggatt ttttattttt 869401 gtccgccttg ttatgatgag agaaccaact tgttaggagg cgtttacatg gaactcaacc 869461 accttgtgac gggcaaaata gcattaaatc aatatgtgca tcgcttagag caaaaggatg 869521 tttcatttta cgtccactac tggggagcga tgacgaacca ctataacaca ctgcttcata 869581 agcattcctt ttatgaaatt tgttacgtgg taagaggtga aggatattac cttgaaggcg 869641 atcgtacata tccgcttcgt gaacagacga tttttttgtc aaagccggag catttgcacc 869701 aaatcaaaag tgaaacaggg ctgttccttt tttacgtcgc tttcgagctg agcgaggatc 869761 agtcaagcgc cgaatggatc aaagtgatgg aagaagtgaa acaaagcccc tttatcacaa 869821 tgcaattgaa agatggcgaa ccgccgggcc tgctttggaa aacgttaatg ctgcaagcag 869881 cgcaacctgt caatgctttt gacaaagaga tcctatctca tttgtcgcat gcattgatcc 869941 tgtcattaat ccaaaccttt ctcccgtacg cccaacgccc gaaacaaaag cagcccattc 870001 acacatcttc tgctttgctg acagaggtga aactgcacat aaaagacaat ctgtcacagc 870061 cgttaaagct gacggatgtc gctagccact ttcatatctc agggaggcat ttatcacgtt 870121 tatttgcagc agaactgggc gtcagctact cagaatttgt ccaaaatgaa aaaataaaca 870181 aagctgccga actgctgaaa tcaacgaatt tgtcgattaa agaaatagcg gaagaaatcg 870241 gtttctcagt acattatttc actcgcgtct tttccgctaa aatcggcagc tctccagggc 870301 ttttccgctc cctttataaa gactcaaaaa tgaccgcatt tcaaatcaat aaaccttttc 870361 aaaaaatcga acaggccaag ccgcacgaat aagatgtcct gaaatgacaa aacaatgtct 870421 tcatatgata aagacgcgag aaatctcgtt gtcttataat ctttttagaa agcggttaca 870481 acaaggggta ttgctgaagg agggatgcat tggcttatgc ttggtgtcgg gtgctctgcc 870541 attcttgaaa gaaggggaag aaagccgtga gtacaaaaaa gaaagaggct gtaataggaa 870601 aagaaagctt agctcataaa gggcttttac gaacgattac attggtatct acattcggcg 870661 gcctgttgtt cggttatgat acgggtgtca ttaatggggc acttcctttt atggcaactg 870721 caggtcagct gaatcttaca cctgttacag aaggactggt tgcgagttcc ctgcttctcg 870781 gggcagcctt cggggcgatg tttggaggac gtctgtccga tcggcacggc cgccgaaaaa 870841 cgatccttta tttagcctta ctcttcatcg cagccacact tggctgtacc ttttcaccaa 870901 acgcgtccgt gatgattgcc tttcgttttc tgcttggact ggcggttggc tgcgcttctg 870961 taacggttcc aaccttttta gcggaaattt cgccggcaga acgcagggga cgaatcgtga 871021 cacaaaatga actgatgatc gtaattggcc agcttctggc atacaccttt aacgccatta 871081 ttggcagcac aatgggggag agcgcaaatg tatggcggta tatgctggtc atcgcgacac 871141 ttccggctgt tgtgttatgg ttcggaatgc tcatcgtgcc tgaaagcccg cgctggctgg 871201 cagctaaagg cagaatgggt gacgccctgc gggtgcttcg gcaaatccgt gaagacagtc 871261 aggcacagca ggaaataaaa gaaatcaaac atgcgattga gggcacagca aaaaaggccg 871321 gctttcatga ttttcaagag ccgtggataa ggcgcattct attcattggg attggaatcg 871381 ccatcgtaca gcaaattacc ggtgtcaatt cgattatgta ctatgggaca gaaattctga 871441 gagaagccgg ttttcaaaca gaagctgcat taatcggcaa tattgcaaac ggtgttattt 871501 cagttattgc ggtcattttt gggatatggc ttctcggcaa agtccgtcgc cggcccatgc 871561 tgatcatcgg acagattggc acgatgacag cccttctgct gatcgggatt ttatccattg 871621 tccttgaagg aacacccgcc ctgccgtatg ttgtgctgag tttgaccatt ttgtttcttg 871681 cgtttcagca gactgccatt tctacggtga cgtggctgat gctctcggaa atctttccta 871741 tgcatgtgcg ggggcttggc atggggatca gcaccttctg cttgtggaca gctaactttc 871801 tcattggatt cacctttccc attttgctca atcatattgg gatgtcggcg acatttttta 871861 tctttgtcgc tatgaatatc ctagcgattc tatttgtgaa aaaatatgtg cctgagacaa 871921 aagggcggtc acttgaacag cttgagcatt cctttcgcca gtatggccgc cgcgctgatc 871981 aggaaatcca aaatcaaaca actcacttat cgtaacctga gataccagga ggaatctatc 872041 aatgaaacta tcttatgtaa cagacagcct agggcatttg ccttttgaag acatgctcaa 872101 ttttgccgca aagcttggga tcgatacact tgaaatgaca accgggggct ggtcgccggc 872161 acctcacttg aatcttgatg aattgctgca aagcagcgaa aaaagaaaag aattttcaca 872221 agcgctggaa aagcggaaca tgacactttg cgcattaaac tgctcgggga accctttaga 872281 tccgggtgaa ttgggcaaat cgcacagaga cataactgac aaaacgatgg agctggctgg 872341 attattaggc gtcaaaaaag tgatcatgat gagcggtttg ccagccggcg gcccggacga 872401 caaagtgccg aactggatca catacacagt aagctggcct cccgttttaa aagatatcct 872461 caactatcaa tgggaagacg ttgcgatccc atattggaag aagcttgtca aaaaagcgga 872521 ggcctgcggc gtggggaaaa tagcgcttga gaacttcagc tctcaattag tctataatcc 872581 tgagactctc tttcggctca gaaatgcagt cggcccgatg gtcggtttga atcttgaccc 872641 gagccatttg ttatggatgg gcgcagaccc gatcatcgca gcaagggagc tcggctcagc 872701 cattcaccat gtccatggga aagatgtcag aattgaaaga tatttatcgg cggtcaacgg 872761 acttttagaa acaaaagaag tgacagatcc tgcaaaccgg gcgtggaatt acgtagctgt 872821 cggctgtgga caggatttac agtggtggaa ggaatttttt tcagttgtaa aaatgatggg 872881 atatgaaggt gaggtttctt tagaaatgga ggatctgacg atgtcacctg aagcgggcat 872941 ccgtacttct gtagaagctt taaaacaaac catcagccaa taggaggttt tcatgatgct 873001 aaatggagaa agaatcatct ctaagccgct tcgctgggca atggtaggcg gcgggcggct 873061 cagccaggtt ggatataaac atcgtattgg agcgctgaga gacaatactg cttttcaatt 873121 aactgctggc gcttttgata tcgatgccga aagaggaaaa gatttcgggg tgaaccttgg 873181 agtggatgcg gaacgctgtt atcccaacta tcaaaccatg tttgccgagg aagcgaaaag 873241 acaggatggc atagaggtag tatcgattgc cactccgaac ggcactcatt atgagatttg 873301 taaggcggcg cttgaagcag gagtgcatgt catctgtgaa aaaccgctgt tcttcacttc 873361 agcagagggg caggaaatca aagcgctcgc agagaaaaaa gggaaaattg tcggcgtgac 873421 gtacggtttt tcaggcaatc aaatgcttct tcaaatgcgt gcgatgattg aacaaggaat 873481 gatcggcgat attcgcgtgg ttgacttgca gtacacacac ggtttttgtg caacagatga 873541 aggtgaaaag ataagcgctg cacagaaatg gcgtgtcgac cctgcgatcg ccgggccaag 873601 ctttgtgctg ggcgatttat ctacccacac gtattatatg tcacagctta ttatgccaaa 873661 gatgaaaatt aaggagctgc tgtgtgaccg acagagcttc gtcggcagcc gcgcaccgct 873721 agaggataat gcccatgtgc tgatgcatta tgaaaatgga gcggtcggaa cgatgtggac 873781 atcgtcaatc aatgccggat gtatggatgg ccatagaatc cggattgtcg gctcaaaggc 873841 aagcattgag tggtgggaca gcaagccaaa tgaactgacg tatgaagtgc agggagagcc 873901 gggccagaca ctcgttcgcg gcatgccgta tttagatgat gtttgcaacg ccgatgaacg 873961 actgggcgcc ttacacagcg aagggctgtc cgaagcatgg gccaatattt atcttaaatt 874021 tgccattgcg atagacgcca aaaaccgtga agatgaagaa atcttgaaca acttggttta 874081 tcctgacatt gatgcaggga tcgagggcat tcgctggatt gagaactgcg tgcgctcggc 874141 aaaccaaggg tcagtttggg ttgaatttaa ataaatgagg gaatgcgccg catatgacat 874201 aaagttcata tgcggttttt attttccaga aactcctgtc aaaaatgccc tgaggcaggt 874261 atgataagaa gggaattggg tatcgggagt gatgagcgtg aaagctcttt tttttacgag 874321 aatgttcacc ttgatggtga gctgtttaat gtatctgtcc attgtgaaag aggataactg 874381 gtttggatat gtatttatag cagcaggtgc tgccatgtat gcagccaatc atgttttgct 874441 gacaaaagag acaaatgcca tctggttctg cctgattgat attgcaatcg gcttttcgtt 874501 cggatttatc tttcccggca caggtttgtt cattattatg ctttgtccgg ttgcggtcgc 874561 cttttttctg cgggggtttc ctaaaagaac agcatggtct gtcttatgtc tttcctctat 874621 tttatttttg accgtcctca tccgtacata tgcgatgttc ggcaatgaat ttgtcattga 874681 tcatttgact agcatgacat tcgttgtctt ctgcggtgtc gtgggcaaat taatccgcaa 874741 gctgttggat gcgcaggata cggcaaaaca gcagtttcag gaactgacgg agtcccatct 874801 ggcgctgtct gctgcacatc aggagctcca tttatatgcg aagcaggttg aagagctgac 874861 tgccatttac gagcggaaca gaatggcgcg tgaaatccat gatacagtgg ggcataaaat 874921 gacggccctt ctcgtccagc tgcagctttt gcgtgaatgg caaaaaagag acagccaaaa 874981 agcggatgag acagtaggtg tctgtgaaac acttgcccgt gaagcgcttg atgatgtccg 875041 cttatcagta cgcactctgc aaactgaaaa cgatccttcg ctaatcgaat cgctgaaaca 875101 gctgacagag gacttttgca aaaatgcagg agtcacaaca gaatttgcgg tcagcggtga 875161 tcctgcaatc atcccgctgt ctctccatcc gaccctgatc agaacggtgc aggaagcact 875221 gaccaatgcc aaacggcacg gcggcgccgc agcctgttcg atacagcttg cctgcacaac 875281 ggacagcatc agccttgtca ttaaggatga cggcaaaggc aatcctgagg cagcacttgg 875341 ttttggtctc ttgaatatga aaaagcgggc agcggagcat ggcggaatga tccgctttga 875401 aagcgaacgg gatcaaggat ttactgtaaa tgcagaattt tcacttgcca ataaaaaatg 875461 gagcttcggg cccgtgcagc aaaaggagag tttatcatga ttaagatcat cattaccgac 875521 gatcaggata tcgtcagaga agggctggca tccctgctcc agctccgaga agagctcgat 875581 gtgatcgcaa cggcgcgaaa cggacaggaa gccttcgaaa aggcgaaaga gctggagccg 875641 gatatcgtgt taatggacat ccgcatgccg gtttccaacg gggtggaggg aacaaaatta 875701 atcacaagct cgctgccaag cgtaaaggtt ttgatgctga caacctttaa ggattcagcg 875761 ctgattgctg aagcgcttga agagggagca agcgggtatc tgctgaagga tatgtctgca 875821 gatacgattg taaaagcagt gatgactgtt cattctggcg gaatggtgct tccgccggaa 875881 ttgactgccc aaatgctgaa tgaatggaag cgtgaaaaac agctgaaagg aataaatgag 875941 atagaaaaac ctaacgagct gctcgacctg accgagcgcg aaatcgaagt tctggctgag 876001 ctgggatacg ggctgaataa caaagaaatt gccgaaaagc tttacattac agaaggcaca 876061 gtcaaaaacc acgtttcaaa tattatcagc aagctggctg tcagggacag aacccaagcc 876121 gccatttact cggtcagata tggtgtatct gtcttttgac atatgacgtt ttgcatatac 876181 gcttctctga aaaggccttt tacaggcctt tttttcatgc cctatgttct atctgccgct 876241 acatgccgca cgcctttctt tcttctacaa tggcaatgga tcaaaaaaag gagtgagacg 876301 acgtgctgca agcagaaaac atcaaaaagg catacggaaa aaaaacaatc gtgaaaggca 876361 tttctttttc cctcaaaaag ggggagtcgt tcggtctgct cgggcctaac ggtgcgggga 876421 aatccacaac catctcgatg atttccggcc ttgtgccgca tgacagcggg aacatcacgg 876481 tgggcggcta tgttatcgga aaagaaacgg ccaaagcgaa acaaaaaatc ggcattgttc 876541 cgcaggaaat tgcattatat ccgacgctga cggctcatga gaatcttatg ttttggggga 876601 aaatgtacgg acttacgcac ggtgaggcca aaaaaagagc ggctgaggtc cttgaatatg 876661 tcggtctgac tgagcgggct aaagataaga ttgaaacatt ttccgggggg atgaaacgaa 876721 gaatcaacat cggtgcggct ttaatgcata agcccgagct gctgattatg gatgaaccga 876781 ctgtcggtat tgaccctcaa tcgagaaatc acattttaga aacggtcaaa cagctcaacg 876841 aaacgggcat gacggtgatc tatacgagtc attacatgga agaagttgag tttttatgcg 876901 accggatcgg gataattgat cagggggaaa tgattgcgat tggcacaaaa actgatttgt 876961 gcagccgcct tgggggcgat accatcattc agctcacggt cagcgggatc aatgaagcgt 877021 ttcttgtggc gatccgatct ctggcccatg tgaatgatgt aacagtacat gaattagagc 877081 tcaaaattga catttctgcg gctcatcatg agaaagtcgt cacaagcctg cttgctgaag 877141 ccactgctca tcatataaac ctgctgtctc ttcaggtgca ggaaccgaat ctggagcgcc 877201 tgtttctgaa tctgaccggc cgcacgttgc gggattgagg agggacggca atgaaaaaaa 877261 gcatatggat cgcatggaaa gatgtgaaaa tcagaatcac ggacagaaaa gggtttatga 877321 tgcttatcct aatgccgctc atcctaacct gtattttagg cgcagcgctc ggatcagttg 877381 ttgacggagg cagccggatt gatgatatca aagtcggcta cattcaatca gaccagtcag 877441 atacagcaaa catgtttaca aaagatgttc tcaaaaaaat gaagtcgata aaggtcacaa 877501 aagtcggcag caaagacaag atgaaaaaac tgattgatga aaagaaaatc gatgtaggca 877561 tcgttatccc gaaccattgg gaagccggca aaacctcagc tgttgttaat gccgctcctg 877621 atcaaacatt gaaaagttcc atcattgaaa cagctgcaag ctcatttata gagcaatata 877681 aagcggtaaa ggaagccgcg tcaggctcaa tggactacat cagtaaaacg gaagctgtaa 877741 agcaaggaaa acttgaccct gcacagtttg cagaaaagct ggcaaagacg ctagaaaaag 877801 aaacaggtga caagcttact attgcggaaa aatctgtcgg cagcaaagcc gttaccagtt 877861 ttcaatacta ttcggcggca atgctttgca tgtttatgct gtttcatatc acagtcgggg 877921 cgaaatcatt tttacaggaa aaggatacgg agacgcttgc cagaatgctg atgacgcctg 877981 cgcaaaaatc cgtcattctc ttcggaaaat ggcttgggac gtatctgttt gccatcatac 878041 aatttttcat atttctgatc gtcacaatca acgtatttgg tgtggactgg ggcggtaatc 878101 tgctgttagt gagtgtactc gggctttctt acgccgcagc tgtatctggt atttcaatgc 878161 tgcttgcgtc gtgcatcagc gatatgaaaa ctgcagatgc gataggcggc ttcggcattc 878221 aattgcttgc ggttctcggc gggtccatgc tgccgctgta ccaatttccg gacgtcttgc 878281 agtctgtatc caaagcggtg ccaaatcgct gggcgcttga cggctttctt tctttaatgg 878341 aagggggagg ctgggctgac cttcaaaagc ctgtgcttct ttttgcggcg atcggctttt 878401 gttcacttgt aattggtatc agacggcttc atacaagata aggaggtaca aaaggtgaaa 878461 aaaattctag ccatttgcgg cattgagctt tctctcattt ttaagaagcc acagaactat 878521 ttgatcatgt ttgctgcccc gcttttgctt acctttgtat ttgggagtat gctcagcggc 878581 aatgatgata aggtgcggct tgcaatcgtt gatcaggacg atacgattct ctcacagcat 878641 tatattcggc agctgaaggc acacgatgat atgtatgtat tcgaaaacat gtctgaaagc 878701 aaagcgtcag aaaagctgaa acaaaagaaa attgccggga tcatcgtcat ttcccgctcg 878761 ttccagacac agctggaaaa aggcaaacat cctgagctga ttttccgtca cggccctgag 878821 ctgtcggaag cgccgatggt caaacaatat gcagaaagcg cattggcaac gctcaatatt 878881 caggtgaccg cggcaaaaac ggcatctcag acagcgggag agaactggaa ggcggcgtat 878941 aaaacggttt tcgccaaaaa acatgaagat atagttccgg ctgtaacacg acagacgctc 879001 agtgataaaa aagagggtgc ggaagcaagt gacacagcct ccagagcagc agggttttcc 879061 atcctgtttg tcatgctgac catgatggga gcggctggaa ccattttaga agcaagaaaa 879121 aacggcgtat ggtccagatt gcttacagcc tctgtcagcc gagccgaaat cggtgctggg 879181 tatgtgctgt ccttctttgt cattggctgg attcaatttg gaatattgct tctttccacc 879241 cattggctgt ttggcatcaa ctgggggaat ccggctgcag ttattgtatt agtgtcactt 879301 tttctattga ccgttgtcgg cattggattg atgattgcgg ccaacgtcag aacgccagaa 879361 cagcagcttg cgttcggcaa cttgtttgtc atcgcaacat gtatggtgag cgggatgtat 879421 tggccgatcg acattgaacc gaaatttatg caatccatcg ctgaatttct tccgcaaaag 879481 tgggcgatga gcgggttgac agagattatc gctaacggtg cccgcgtcac agatattctc 879541 ggaatctgcg gcattttgct tgcatttgct gcgatcactt tcgcagcggg gctgaaagcg 879601 ctccgagcct aaaaaacatc tgccgtttag gcagatgttt ttttgcatgt gggtacattc 879661 gtatgggtgc agcctgaact gcggttaatc cttatctatc atagctaaaa ttgattccag 879721 ccaagaaacg taatttttct cccgctccag cgctttcgtt agcacaagat agtggccgaa 879781 gtccggtgaa gaaaatgaca tcggctctgc tgaagccata agcttttcat agcttccctg 879841 taagtcagaa agcttggcct ggcgtttttg cagctggtct ttgaacaaat cagaagcctc 879901 ctggcgcgat agacaagaaa tgaaataagc cttcagcata aattcatcct tcaccgtctc 879961 gggtatcggc tggtggcgga tcagccagtc atgcagctcc tgctttccgc tgtctgtcag 880021 ggtgtacatc tttttctcca gctttgtgcc ctgaatcgtt gtccggaacg tgataaatcc 880081 ttcatccgtc agctttttga gctcagggta aatctggctg tgcttggcgc tccaaaactg 880141 gccgagctcc tctttaaaat aactcgtaat atcgtatcca ctcaattcgc cttttcgcaa 880201 aagccctaat atggcgtatt ttaatactct catgctatcc tccgtgtctg gctgtttcgc 880261 aaaacagatg agccggtgct caactgtgat tctaactgcc tattcccctt attatagaaa 880321 agggaggaag ggaacacaac cgggctcttt ggaaatgaag ataaaaggtt tgtcagaagg 880381 tatccgattt atctccgtca atataaaaga gatttaaatt taattttcag aaaaaatagt 880441 aacgatattg attttttata tataatagga aattggtggt atgaaaattt tttgggggaa 880501 taaacgtgaa aaaagtactt atggcattca ttatttgttt atcgctgatt ctatctgttt 880561 tagccgctcc gccgtctggc gcaaaagctg agtcagtaca taatcctgtc gttcttgttc 880621 atggaataag tggtgcatca tacaactttt tcgctattaa aaactactta atttctcaag 880681 gctggcaaag caacaaactg tacgcaattg atttttatga taaaacagga aacaacctaa 880741 ataacggccc gcagcttgct tcatatgttg accgtgtttt aaaagagact ggggcaaaaa 880801 aagtagatat tgtggctcat agtatgggag gcgccaatac gctgtactat attaaatatt 880861 taggcggggg caataagatt caaaatgtcg taacgcttgg aggggctaat ggtttagtgt 880921 catcaaccgc gctgccgggc acagacccta atcaaaagat cctctataca tctatttaca 880981 gtctcaatga tcaaattgtc atcaatagct tgtctcggtt acaaggagcg cgaaacatcc 881041 agctttatgg catcggtcat attggcttgc tttctaatag ccaagtgaac ggctatatca 881101 aagaagggct gaatggcgga ggcctcaata caaattaata tcttcaaaaa acaacctgct 881161 gtctccgtta cagtgggttt tttcgtctga gaaagccata gggtcttatg accttagtct 881221 atcatgcata cgtcaattta tgacatcagg cactttttca aatagagcgg acatgttaag 881281 gtacaaccat cgatttctat caatttgaaa taaaaggagc gctgttatgc aaattaaaga 881341 aatttttatg atccgctgca tttcgtgctt aagtgtcgtc ttgctccata tcatttcaat 881401 ggtcctgatg cttcaggcag aagctcttgc agatatttct cacactgttg attctttccg 881461 cacactcctg atgttcagca cgcccgcttt tattttcatc tctgaatttt tactggcccg 881521 ttcttatcct gatggggtgc ctgacggttt tttaaagaag cggggaaaag tgatttttgt 881581 tcctttttta tttatcgcag ccatcgatgc gctgctgatg accagtgcga tggggggaga 881641 ggtaaccttt ctcgcgtttg tgcaaaaata tctggcgaac gtattcttag gaaactttat 881701 cggatacttc attctcgtca tctttcaatt ttacatgctg catatgatgt ttcatgagta 881761 tttgaaaaaa gcatcgccga aatgggtgct gtctatctca tttgtggtga cagccgctta 881821 tttaggctat ttctccgcag ccagcccggc tcctgcttct gaagagggag gggcatttcc 881881 gttcttctgg gttccgttcg caggctggct tttctacttt tgtctagcct actattgcgg 881941 aaaagaatac aagcgttttt tagcgctgct gaaccaatac cgctgggtgg tgtacggcgc 882001 cgcaattgct tctggggcgc tggttgtcac tgtttcttat gtcggtgaaa tcggcatgat 882061 cagctcgaag cggcctgata tcatgctgta ttcaacaagc atgattttcc tgtgttttca 882121 tttgttttcc aaaatgaagc atgtgccgaa aatcatgatg tttatcagca actattcctt 882181 ttcgatttat ctgcttcatg cctattttat gattataggc tacgtgttgc ttttgaatat 882241 gcccgaaatt cctgccgtac cggctgttct cctgttgttt gccgtgtgca cagccggccc 882301 gattatgacc tcatgggcgc tgaataagtt caaatacggg tatttatttg tggggaaaat 882361 ttatcagcca aaacagaaga aggtaacagt cgaagtgcgt gatcacgcag ggtgaaaaac 882421 aagcggcagg agggctcctg ccgcgtttct ttacttctca tccgcttgca gaactgtttt 882481 taaatatagt tttgcagact cagcaagtcc agatacatca gccttttctt catcgaaata 882541 cagggcgttt tgaatgatgc cgtcattcat attgaggaaa aacttggcga tagtcgcaag 882601 aggctgaacc ggctgaaact ctccctgatc gatccctttt tgcaatagcc ttgaaaacct 882661 ttccacaaaa agatcatacc ttttctccaa atactgccgc cgttcttcat tgcgccaagc 882721 tgtcactaaa tattcaaatt gcaccggcgc cagcgtatct gctacatctc gcaggccctc 882781 agtcagttca tccaaatagc tggaaatgga ggcccaaaca ctttggtgtt cagctgattt 882841 atcaagcttt cggagtcctt catccagccc tgtttcaata atgcggcgaa acatctcctc 882901 agtgcttgaa aaataaagat agacaccgcc ccggctgaaa cctgactctt ctacaacatc 882961 cttcatcgtc gttaattcga atccttttcg tttaaaaacc gttttggcag cctctaaaat 883021 ctctgcctgc cgtttatcct tgtgctcctt tgttactttt ggtgacaaga tatcgcctgc 883081 tttctgcaat tttcttacct ataagtgtaa tcaacccaat catgatcagc aagcagccac 883141 agacaagaaa agcaagtgat acaccgatcc attccgccag cacgcccccg cccgccatgc 883201 cgaggataga ggcgagggtt gtcgcactct gaatagcgcc gaacacccta ccgctgtaat 883261 cgacaggcac tgttgtttgc acgagaatct gaaatggaat atggacgagg ccgaaagccg 883321 cccccatgat gaaaaaagca aatataaaga gagtgatgcc ggcaattccc ataccgctta 883381 ggaatggcgc acctccagtt gctagtccaa gaagaagggt tccagctgag aaataaagca 883441 aataagaagt gattcgccgt ctgccggtaa tggccgctgt aaggagcatc ccggctccgc 883501 ttacggccat gcaccagcct gccagctcgg gcggagctcc tgaaaaggag cggataagaa 883561 taatcgcttg ggaatcacca atctgcaaaa caaagagaac gacacaagct gttagtaagc 883621 ctgttaatag aagcggcatc cgtttcaaaa actgaaggcc ttccttgata gaagtaagtg 883681 ctgctgtttt ttcttgaggt gtattggctt tttgtaaaaa agcatctctg ggaaggaaaa 883741 acaaaatgac agcggaaaga aagaaggcgc cggcgtttat ataaaaaaca gagtgtatcg 883801 agaaagcagc gatcagcgtg ccgccaaggg cagggccgaa gatttttgag ctgttatcaa 883861 tgatgctgct gacggaaacg gcctgctgaa tgtgtgcttc cggagccaat tccttaagct 883921 ttccgttttt agcaggtaaa aaaagtgaag aaaaacagct ctgaacggat agcaatacgt 883981 aaagctgcca aagctcactg acataaacgc agctgataac agtgagggca cggccgattt 884041 cagatagaaa catgatcgtt tttctgtcaa aacggtcggc aagcagaccc gatacaggtc 884101 cgagtacaat gacaggcaaa gcaaacgaca tcattaaaag cgacatatct aatggagaag 884161 catgaagctg aaaagcggct aatgttagca cggccaaaat gtgaagccag tctccaagtg 884221 aagaaatggt ttgcgaggct aacagtgtca tcagtccttt ttgattgcga aacaacggtt 884281 tttccatgat tcatcctcct gattattaaa atgacactag tgtcgttttt aattgtatgg 884341 gaaaaagaca caatatacaa tctttttctt gtaaaataaa ggagaagatt gaatagaagg 884401 gagaacattc atgacatcag tcaatctaag ctacccaata ggagaataca agccgaggga 884461 atccatatcg aaggagcaaa aagataaatg gattcaagta cttgaagaag tgccggcaaa 884521 attgaagcaa gctgtagagg tcatgacgga cagccagctt gacacaccgt accgggacgg 884581 tggatggacc gttcggcaag ttgttcatca tctggctgac agtcatatga acagctatat 884641 tcgttttaaa ttgagcttga cggaagagac accggctatc cgtccgtatg atgaaaaagc 884701 atggtcggag ctaaaagact cgaaaacggc agatccgagc ggctcactcg cgcttttgca 884761 ggagcttcac ggaagatgga cggctctgct ccgcaccctg acggatcagc aatttaagcg 884821 cggattttat caccctgata caaaggagat cattaccctg gagaacgcgc tcggcctgta 884881 tgtctggcac tcacatcacc atatcgctca tattacggag ctttccagac ggatggggtg 884941 gtcttaacgc ttttgccggc ggaaagccgg aatactgata gcagcaatca ccagaagtga 885001 gaccacagca gccgctgcat ataaatgatc atagccgctg gcgacactcg catgaatggc 885061 gtcgcttatc gcggttttga cttcaggaac gggaatgcgt tcgatttgtt cttgtaaaga 885121 agaaacttca gaactgtcga tctccggaat catctgcatc gccttttctg aatatccgct 885181 gtccgataag cggctgttga tctcatcacc tatttggtca aacccggctg tgataaaacc 885241 tgcataaaga gtaggcgcca aggtcagtcc aatttgcctt actaatgaaa gcgtgccaag 885301 agctgtaccc ttatttgttt ttgccgcttc tgatacaagg acgttcagcg gagcgcctaa 885361 cagaaagcca aaaccgatcc cagctgccac acttgcgatc acaaactccc atttttccgt 885421 gacccagagc ggaaataaag caaaccccgc acatgagatg attcccgaaa gaataacggt 885481 ttttacagga ccttttttgt cggtaagtgc tccgccaagc caagcgccga ttccggaagc 885541 caacgcaagc ggtgtcatcc aatagcctgc ttttgcggca gggacaccca aatactgttc 885601 gacatatgac gggataaaaa tgactgccgc caagagcccc ccggataaca aaccgatgat 885661 aagcgtgcgc tgaaacatat ggtttcgcag cagagaatac gccaaaatgg gatcgcctcc 885721 tcgcatttca actctctttt catacgagat aagcgctgca aaacagagta tgccaaaaat 885781 aatacatcca taaacctccg gattccccaa gctgtgtaag agatttgccc cgtcaagatt 885841 ggtcatgccg tacatcacag ctaaaatcga cagggacaaa aggaagattc cggccgcatc 885901 gaggcgctta gcctcaggtg cttttgtttc cgcgataaaa catgcgccga aaacaaccaa 885961 tagcacggca atcggcaaat taatcaaaaa tagccaatgc caagacccgg tccaatcaag 886021 cagaaagctt ccgatatttg gcccgagcac agcggccatc ccgttcattg cgccaagcag 886081 cccaagcgcc ttcccctgtt tttcctttgg aagggtcgcg agaatgtgag agctgccgat 886141 gatgaaaatc ccgccgcctc caagcgcctg aatcagccgc gatatcagaa agagcgggaa 886201 gctttggctc aaagcaacaa gcaaagaacc aagtccgaac aggcaaacct caatgagaaa 886261 gagttttttt ctgccgtagc ggtcggaaag ttttccgacg attggcacac tgacgctaag 886321 accgagcgta taaagggtaa tgccccatga tccccaggaa ggggaaacgg aaaacgactc 886381 gtttatcgtt gttaaagcag ccgaaataat tccgttatct aaagcagcca taaacacgcc 886441 aatcgtaaac aggctgattg cccacttttg gcttttctgc tctgttaatg cttcagacat 886501 tttcgtcaac tccttttagt tcacttgaaa tatattattc attttaaatg aactaaatgt 886561 caaataaaaa aagcctgctc ccgcagtttg cggatgacag acttactgat ttattctttt 886621 ttcgcattct ctaatgctct tgaaaggata gacagccctt cgtaaacagc ctgcttttct 886681 tcaggggaca gcagctctaa tgaacgcttc aatttcaggt ggcccttttc atacaaaccc 886741 cggaaaatct ttttcgcatt ctctgtcaac tgaacaacta cagagcggcg gtcctcttca 886801 gaatgtgagc gtttgacaaa tcctgatttt tcaagccggt caagcagccc agttgtattg 886861 gacagggaag cccccatttt ttcagcaatg tcgctcactt tcaatgttcc atggttgttt 886921 aatagcatca gcaccttcat ttgcggcatg ctcatatcca gtttcatcca ctcggacaca 886981 tcaccgagcc cggcggacgt taagactttc atatagagca cccatatttc ccgttcctcc 887041 gatgaaagaa tgttttcgtt taagactgtt gtatcgtgta aattatattc catttcatca 887101 cttcctcatc attcactcct cttaccatat tactcgattt tcactcctga aagaaagtga 887161 gcagaaaccg catgcgggac tttgtccgaa aaataacggt agtgtataat gagttggaga 887221 ttattggggg agaggatcga actagaatat gattggagag accattgctg attaaaaaga 887281 atgctttatc aatattaaaa atcgtttttc ctattgctgt tttgctattt gttatttatc 887341 aatcgaaaaa agaactgaca aatctgtcat tcaaacgtac gctcatggtc atcaacggac 887401 tggaacgaac ggatttattc atgcttgtgt tgatcggctt gctggctgtt gcggctatgt 887461 cgctgtatga ttacgtcctg aagtactcac tgcgcctatc gatcacaaac ggaaaagttt 887521 tcagggtttc ctggatcgcc aattcattta ataatgtgtt gggattcggc ggtttagccg 887581 gagtcgggtt aagaatgatg ttctataagg agcatacgaa agaccataag gcactcgtga 887641 aaggaatcgc ctggctcaca tcatctatgc tgctcggatt atctgttttc agcattttcg 887701 ttgctgcgag agtgctgcca gttgatgaag tgattcatga gaagccttgg ctgtgggcgg 887761 tcgttatcgg ttttgcactg atattgccgt tatctttagc ggtgtccaaa ataaaagacc 887821 gcaaagctgg ggacgaagag aatgcggata aagtgaaaaa tccgattttc gcatatattg 887881 gagcttcagt tgttgaatgg ctcatggccg ggaccgtcat ctattttgct ttgttcgcta 887941 tgggcattca tgcagatatc aggtatgtgt tcggggtgtt cgtcattgcg gcgatcggag 888001 gaatgatcag cctcgtgccg ggcggcttcg gctcgtttga ccttttattt ttgctgggga 888061 tggagcagct tggctatcat caagaggcca tcgttacttc tattgtgttg tacaggctcg 888121 cctactcatt tatcccattt atcttgggac tgttctttgc cgccggcgac ctgacggaaa 888181 atacaatgaa gcggctcgaa acgaacccgc gcatcgcacc ggcaattgag acgacaaacg 888241 ttctgcttgt tgttcagcgt gcggtattag tgagaatttt gcaaggctcg ctttccctta 888301 ttgtgttcgt agcaggtctg attgtcttgg cctcagtttc cttgccgatt gacaggctga 888361 cggttatacc gcacattccg cgcccggcgc ttttgctgtt caacggcctg tccttaagct 888421 cagcgctcat tctgctcatt ttgccgatcg agctttataa acggacaaaa cgttcctaca 888481 cgatggccat tacagcgctt gtcggcggct ttgtgttcag ctttttaaaa gggcttaaca 888541 tcagcgcgat attcgtactg ccgatgatta tcgtattgct tgtgctattg aaaaaacaat 888601 ttgtccgcga acaggcatcc tatacactgg gacaattgat attcgctgtg gcgctgttta 888661 ctgtggcgct ctttaactac aatctgatcg cgggctttat ttgggaccgg atgaagaagg 888721 tgctgcgtca cgaatatttc gtccacagca cctcgcatat tacacatgca accatcatgg 888781 cgatcatcat tgtgccgctg ttcttcttga tatttacagt ggtctatcat aagagaacga 888841 aaccgatcgg agagaaagct gaccctgagc gtcttgctgc gtttctcaat gaaaaaggcg 888901 gcaacgcgct gagccatctt ggttttcttg gagataagcg gttttatttt tctagcgatg 888961 gaaatgcact gcttctgttt gggaaaatcg ccagaaggct ggtcgtgctc ggcgatccat 889021 ctggccaaag agaatcattc ccgctcgtgc tggaagaatt tctgaacgaa gcgcatcaga 889081 agggattcag tgttttgttc tatcaaattg aacgagagga catggcgctg tatcacgatt 889141 ttggctacaa cttctttaaa ttgggtgagg aagcatatgt agatttaaat acatttacct 889201 tgactgggaa gaaaaaagcc ggccttcggg caatcaataa ccgctttgag cgggaggagt 889261 atactttcca tgtggatcat cccccatttt ctgatgcgtt tttggaggag ctgaagcaaa 889321 tctcagacga atggctcggc tcgaaaaaag agaagggatt ctcgctcgga ttttttgatc 889381 cttcctattt acagaaagcg ccgatcgcct atatgaaaaa tgcagaagga gagatcgttg 889441 cattcgcaaa tgtcatgccg atgtaccagg aaggagagat atcggtcgat ctgatgcgct 889501 atcgcggcga cgctccaaat ggcattatgg acgcattgtt tatccgtatg tttttatggg 889561 caaaggaaga gggctgtacg tcatttaata tggggatggc acccttggcc aatgtcggca 889621 ctgcctttac atccttctgg tccgaaaggt ttgccgctgt catttttaat aatgtcagat 889681 acatgtacag tttcagcggc ctaagagcct ttaaagaaaa atataaaccg gagtggcgag 889741 ggaaatactt agcgtatcgg aaaaacagat ctctttctgt caccatgttc ctcgttacac 889801 gtctgattgg caaaagcaaa aaagactccg tctaataaga cggagtcttt ttttatttcg 889861 tttttaagaa gtaggtttca atatcatcaa gcaggtagtt tgcggcttta attccgcctg 889921 cggttgtcca tacgacgtca tcgacttcat gtgcattacc tgacttcacg gccttcaggt 889981 ttttccatag tgaactgctt gtccactgat tggcccattt ttcattttct tttgcattat 890041 cggctttata agtgaaataa aacagcacat cagcatccat atcaggaata gattctttac 890101 tgtcggttga gaacgtaaat tggtcctttt gtttcttaaa cagttccact tgtttttcag 890161 ggcgtttgaa gccaagctgg tctaaaataa tcccaggaaa tgaatcggta taatagattc 890221 ttgattcacc ggataaaaag cgtacgactg aaacggtttt gtttgtctgg tcgcccagct 890281 tgttttttaa atcagaaaca cgtttatcaa aatcggcaat gacttccttg cctttgtccg 890341 ccttattcac cgcgttggcg tatagagtca ggttatcctt ccagttcccg gccaaagatt 890401 cagcaaaaac agtcggcgca atcgcattta actgatcata aattttttcc tggcgcactt 890461 tgtttccaat aatcaaatca ggctttaatt ctgcgatggc ttccacattc ggttccgttt 890521 caagaccgac gtttttaaca cctttcatgt catctttcag atagtcatac cacgggtcgc 890581 ccttccatga ctttacggct ccgaccggct taatgccaag cgctaagagc gcctctgttc 890641 cttcattagt taaaacaaca atccgttttg gattggcggg gatgttgtct gatgtcccca 890701 ttgcatgttt gaccgttctt gttttgctgc ttgacacctc gctgttgctt gaactttctg 890761 aactattaca ggcagaaagt accataacgg ccattaaaaa tacgaatagc atgctgatat 890821 gctttttcat ctttttcctc ccaatattga aattcattat catttagatc ataataagca 890881 gtgttaagag tgtcaatccc taattgagga ttattctcaa aaacaaacat tacatagtaa 890941 ataactagga gaattagatc atgatctgca aaaaggcatc ttcaaaatgg attgtgttag 891001 tatgtctgat tttcatttta ctgacggctg tctgcgcaag cgtcgtgtat ggctatacag 891061 gtacgtcatg gagacaggtc tatcaggcgt ttacttcctt caatggaaca aatgagcatg 891121 tcatcatcaa ggatgtcagg cttccgcgcg ctttggttgc gacagtcgtc ggcgcctcgc 891181 ttgcagccgc gggcgctctc atgcaggcgc tcacaaaaaa tccgcttgcg tcaccgggga 891241 ttttcgggat taacgccggt gcaggttttt ttattgttgc cggatcgttt tttctgcata 891301 ttcagtcacc tcaggcatta gtatggagct cgtttctggg ggcagcattt accgctgcga 891361 tcgtctatgc agcaggctcg cttgggaggg aagggctgac gccaatcaaa ctgacgctgg 891421 cgggagctgc catggcagcc atgttttctt ctctgacaca gggcttgctg tctgtcaacg 891481 aactcgagct tgcccaggtg cttttttggc tgactggctc tgtgcagggc cggagtctgg 891541 atctgttgat gacgatgttt ccatatgcag cggcagcgct ggtaatctgc ttctttctcg 891601 gccaaaaaat taatctcctc gttatgggag aagatgtggc aaaaggactc ggccaaaaaa 891661 caggcctgct gaaatttgtg atggcgcttt gtgttgtcat gcttgcaggg tccgctgtcg 891721 ccattgccgg gccgatttct tttatcggca tcattattcc gcattttgcc cgctttgtcg 891781 ttggtaatga ttatcgctgg gttctgccat tttccgctgt tttgggtgcc attttgcttg 891841 tttgcgcgga tatcggtgcg cgatatatca ttatgcctca ggaagttcct gtcggggtca 891901 tgaccgccat catcggaatg cctgtgtttg tgtacatcgc aagaaggggg gcgaagctat 891961 gaaacttcgt tttggcgtta ctgcggctga aaagaaagca tggatcgtct ttttggtttt 892021 actggggtta acagctgctg tactcatcat aagcgctggt ctcggacaaa ggtttattcc 892081 tccctgggat gtagcaaaaa cattctttgg tgcaggttcc aagctggatg aactgatgat 892141 catgtcgttc cgcatgccaa gaattttgac ggctttatgc gccggtgtct gcttggcagc 892201 ggcaggcgcg atattgcagg ggctcgtcag aaaccctctc gcatctccgg atattatcgg 892261 aataacagga ggagcggcgg tagcggtcgt gcttttaatg atgttcttct cagaccgcag 892321 cagttcactt acgatcagtc tgtcatggct tccagcagcc gcatttatcg gcgcatcggc 892381 tgtcgggctc atcgtctatt tactggcata caaaaatggc gcctccacat ttcggctggt 892441 gcttatcgga atcggatttt caatgtcggc gcaggcgatg actaccctgt tgatgatcaa 892501 aggcccgatt taccgagcat cacaagccaa tgtgtatatc actgggtcag tttatgggtc 892561 aaactggcag catgtaaaaa tagctattat cttatctgtc attctcttat tcatttgttt 892621 tgtcgcgcta aaaaatatga atatacaggt gctgggtgaa gatattgcgg cgggtgcagg 892681 aagcgctgtg cagcgaaatc gttttttctt gctccttttg agtacggctc ttactggttg 892741 tgcagtttca gttgccggca caatcggttt tgtcgggctg atggcgcccc atattgcaag 892801 acggcttgtc ggctcatctt atggcgcgct gctcccagcg tcggcactta ttggagctct 892861 gctcgtttta acagctgata tcgtcggcag aaccttattt gctccggtgg aagtgccggc 892921 cggcgtcttt acagcggcta tcggcgcacc ttattttatt tatttgctct ataaaacaag 892981 aaattcttaa tcgttacacc cattttctta aaaaagaaaa tgggtttttt tgataatgac 893041 tgaagattcg taattatttt tgctatactg acagagacat tgataaagaa agggcggcag 893101 atgaatgaaa gaagcagagg tattaaaata tgaagcattt acaagcagtc ccggcaaagg 893161 aaaccccgca ggcgtcgttt tgcagggaga cgattatacg gaagacgaga tgcagatcat 893221 agctgaacgt gccgggtatt cagaaacctc ctttatccga aaaagcgagt cggccgatct 893281 tgaactccgt tactttaccc ctggacacga aatgaatttg tgcggtcatg cgacagttgc 893341 ttctctttac gcattatgtg agaaaggaat gctggagagc ggtaaaacgt acagcatcca 893401 aacgaaagcg ggtatcctgc ctgtgaagat ttctgaaaaa gatggccgca ttcatatcac 893461 gcttgaacag gcctctccgc aattcaaacc atttacaggc gatcggaaaa aacttgcgga 893521 cgcactgggt atcaccgatg aagattttca tgaagacctt ccgattgtgt ttggcagcac 893581 tgggatatgg acagccatcg ttccgcttaa atcattggag gcttccaaaa aaatggtgcc 893641 agataacaaa caatttccgg aagtgttagt tgatctgcca aaagcttcag tccatccgtt 893701 tacctttgaa accgtccatc ccgacagcga cctgcacggg cgccactttt catccccgta 893761 ttcgggaacg attgaagacc ccgtgaccgg cacagcatcc ggcgtgatgg gggcttatat 893821 gaaacattat ggcaatgccg agcagcataa atttatcatt gaacaagggc aggaaattgg 893881 aaaagacgga aaagtggaga tcgaaatgaa cgaagccggc ggccatgtga aagtgaacat 893941 gacaggaaca gccgtttact cagaaacccg tattcttaaa atctaatacg gatgatggtt 894001 tacaaaaaga tgcactttcc gttatcatta tgaaatgata atcattttca attgcatagg 894061 aaggtgagac ggtatgcctc aaaccgaaca aatacatcag cattcagtac tgagggacat 894121 catacgcagc agaagatcga ttcgaaagtt taaacaagag ccagtacctt cagcagtcat 894181 tcttgacatg cttgaaacgg caaaatatgc gccaaatcac agagtgacag agccatggag 894241 atttatttac gtttccagtg agacaggtaa agcgaacctc attaatacat ttgcagcgtt 894301 ctctaagaaa tccaagccgg atatgacaga ggaaaagctt caaaatttca aaaacacact 894361 tgggcgcgtt ccgggatttc tcctcgtcgt gtttcaggaa gatgaaaacg aaagagcgcg 894421 ggacgacgat tttgcggcaa caagctcgtt gattcaaaat cttcagcttc tcgcttggga 894481 aaaaggaatc ggcatggttt ggaaaagcgg aaaaatcctt tatgacaaag aagtccatca 894541 ggcctttggt ttacaggata atgagcgttt cgccgccatc atacaaacag gttatcctga 894601 cgaggcgccg gaagtgaaaa aacgcacacc gatccgcgac cgattcactg aaatgtaaaa 894661 aaccccttgt ctcaaacgga gacaaggggt ttttcattaa cgagatttct ttttcgctct 894721 gttgtcggct gctttcgcac gctcttgcgc ttcgcggtca tctgcatcag caagctcggt 894781 tgaatattct tcgtaaacgc cgtcagtttc cctttttaag gcatcgggaa cttgtggaag 894841 cttttgtttg tttttatcac ggtttttgtg gatatgattt ctgcccatat caaattcccc 894901 ctaaaaagtg atatcaaaca aatatagtat ttggttttaa ggggctatgt attcctactt 894961 ccgcttagca gctttttccg cttttttaaa ttcgcctgaa taaagaactt cctgcatttt 895021 tttcaggttg gcgccttgct ggtgcttctc cctctttttt tccataaaaa ggacctcctt 895081 caaccatgtt attcttaagg ttgacgcttc ctgctgtttt tatacagtct ttcggtccgc 895141 tatcagctgt gagagtgcaa attcaagatc cgaatatgta aaacgaaatc cagaggttat 895201 cgcttttttc ggaagagcgc gctgtccttt cacaatcaaa agactcattt cacccaatgc 895261 ttttgataaa aagaattccg ggacggggag ccagtgcggg cggtgcttca cccgtgcaat 895321 cgtttttccg aattgcttca tgtccacagg attgggcgcg gtgacattca ttgggcctga 895381 gatgccggcg ttttccaccg catatcggat catctgggcc gcatcctcga catgaatcca 895441 tgacagccac tgccttcccg ttccgatcgt tccgccggcc agaaacttat aggggagaat 895501 catgagcggg agagcgcctt tttctccaag catcacgcca aatctcgcat aaactgtccg 895561 gatgcccatc gcttcaatat gctgtccttc cttttcccac aggtgtgcag tatggctgag 895621 aaaatcctca tctgacgttg cagaatcctc tgtgaaagtt ttctcaaggc ttgtgccgta 895681 aatgcccacg gcactggctt ggatcaatgt cttcggcttc tccttctgtt tctgaataag 895741 ccgctgcact tcacgcgtcg cattgatacg gctggagaga atgtgctgct tcgttttttc 895801 tgtccagcgg ccaaaaatcg attttcccgc aagatttatc cagacatcaa tatgaggaag 895861 ttcctgctcc ggtgcggctc cttccgacag ccattggaca tatgtcatat ttttttgttc 895921 agtttccctt gcgtttcttg ataaaatata aacatggtgt ccctggcggg taagaacgcc 895981 tgtcagatgc tggccgagaa aaccggttcc gcccgtcatt gcgatattca tgaacatctc 896041 tcctcatcgt tctaataaat atactttacc tcattgtaat aaaagaaaac gcgtttcagg 896101 cctgagaagg gagattaaga tgccgtttat tacaaaaata tcaacgcaaa aaaagaatac 896161 ggaacgcttc aatatttttc tggatgataa atacgccttc agcgtggacg cggatgtgct 896221 cgtgaaattt gagctcaaga agggaaaaga actcgatgat cttgacatca ttgagattca 896281 atacggcgat gaagtgaaga aaggcttcaa ccgtgcgctt gactttttat cctatcgaat 896341 gcggtcgacg aaagaggtcg aggatcactt aaagaaaaaa gaaacctcgc cccccgtcat 896401 tgcggaagtc atccataggc ttaacgatta caagtactta aacgaccagg aatttgccgc 896461 agcctatgtc agcactcaca aaaaaacaaa cggaaaaggc cctgatgttt tgttcagaga 896521 gctaagagcg aagggaattg atgacgatac aattaaggag gcgctaagtt ccttttcctt 896581 tgaagatcag acaagagaag cggtcaagca tgttgaaaag cttctcaaaa aagataaaaa 896641 gctttcgacg aaagaactca aacagcgcgc ccagctgcag cttcagcgca agggcttctc 896701 atttgatgtt atcagcgcgg cgatggatca gattgaatat gaaaatgatg aagacacaga 896761 gaaagaagcg ctgcgccttc acgcggaaaa agcgtttaga aaataccgct atgacggctc 896821 atatgaaagc gccatgaagg tcaaacaatt tttattccgc aaaggattct cactcgattt 896881 aatcgagcaa ttactgcagg aagaggagta ctgaaatgga gaaacgatac agtcaaatga 896941 caccgcatga actcaatacc gaaatcgcat tactttctga aaaagcaaga aaagccgaac 897001 agcatggaat cataaacgaa ctggcagtgc tcgaacggaa aattacgatg gcaaaagcat 897061 atttgctgaa cccggaagat tactcaccgg gagaaacata tcgtgtggaa aacactgagg 897121 acgagtttac catcagttat ttaaatggcg ttttcgcatg gggatacagg acctcttccc 897181 ctcagcaaga ggaagcgctg ccaatctcag tattgcaaga aaaagaataa agcgtaacag 897241 gaggctgatg atcagcctct ttttgtttgc agcacattta cacgaattct taaagaaaaa 897301 atcattgaat tcacttgaaa aatcttttaa gatgaaactc gttgtttttt aaaatcaaag 897361 gaggcgatga cgttgagtat caaaaaccca tctgtaaaat ttattatatt tgttcttatg 897421 atttgtacat tttcaatcgg ctatacagaa tacgcggtga tgggtatttt gacgtcgatt 897481 gccaatgact ttcatataca ggtttcatcc gcagggcttc ttgtcacggc ttatgcggca 897541 agcgtttgtt tgacagggcc gctcgtcacc atcatttccg tcaagcttcc gagaaagcct 897601 gtgcttcttg ggctgatggc gatatttatc ctttccaacc tgatgagcgc actggcgccg 897661 aattttgcgg tattggccat ttcaagaatt ttatctgcgt ccattcacgg cgctttcttc 897721 gcgattgcca tggtattcgc aagtgaaatg gttccgccgg aaaagcgtgc tgcagctgct 897781 gcttcaatga acggcggact gacagtggct ctaatgcttg gtgttccatt cggctcttat 897841 ctcggagatg tcctgaattg gagagcggtg ttttccatca ttacggcact tggtgtcatc 897901 ggatttttag gccttatggc tgccgtgccg aacagaaaac caaaagtgat cccaatgctt 897961 atgaatgagt ggggtgtttt taaacacaaa caagtgctgt tttccttcgc gattaccatt 898021 ttaggctatt ccggtgtctt tatcgcctac acctttatcg aacccatttt gaggcattca 898081 gccggattca gcacggttgg cattacaggt gctctctttg cgtatggatt gggaggcgtt 898141 gccgggaatt tctttgctgg aaaggtaccg ctgcctttgc tgactcggac gatgatcggc 898201 gtaatgatcg gtttaatcgg tgttctggct gtatttcctt acatcgccat ttacccggct 898261 gcagccattg tggcaacgtt cctattcggg gcatgcgcat tcggcacgcc gcctcttctg 898321 caaacaaagg tcatttcctc atctgagggc ggcacaacca ttgccgcagc tgtcagcgta 898381 tcagcattta accttgccaa tgcccttggt gcatggatcg gcggaatgat tttaaacgga 898441 acaggctctt attcctggct gtttgcagga ggtgcgctta tgaccgcatg cggacttgtg 898501 ctttctacct tcgcacactt atcagaaaag aagagcgtct acgaatatca agtcaataaa 898561 gggtaaaaaa cagctgcagt gtatgcagct gttcttcttt accgtttgcc tgaggctctc 898621 attctttctt gaggatgctg attgatagat ccgtcagcac gctttgaagc atagtcgtcc 898681 tttgctctcg gttcaccctg aaatttgttt tcgttttcgt aaggaaatcc tttttcttta 898741 tttcggacca tgtcatatcc ccctaggttc gagatcaaaa agttgcgtct tttcagatga 898801 agacgtaagg ttagtatatg gagaacacca cgtaataaag cgttattttt ttcctgaaga 898861 aaggagactg cacacatgaa tatgtacatt gagaaactga ctaatctgct tctggaaaag 898921 aacgagatga tcagctatat acaggcaaaa acgtgggtgg aattgttatg gagcgatttc 898981 gaagcaacct acgcaaaagc cggacacgcc tatcaaggtg aaaaaatgac tgaaaaaatc 899041 gtcacacaat ggattgaaaa ctatggcggc cagctccacc tttttcaaag ctcccgtaac 899101 gacgtgaatg attacttaaa tcaaagcaga ggccttttgc attaaaaacc tgccgttaac 899161 gaccggcagg ttttttcatt ttcttaaaat taccttaaca ggaagaaatc ataaacaaaa 899221 catgtttcac cagcctgtca atcagggaat accacttata tcttgtcaaa atgcgaggag 899281 gagctttata tgaaaaagaa acaagtaatg ctcgctttaa cagctgccgc aggactgggt 899341 ttgacagcac ttcattccgc tcccgcagca aaagctgcgc cccttcacga catatctgtc 899401 agcatgccat catccgatac ttacatcata aaagcaggaa agctgaatgt ccggactgag 899461 ccaaatcatg aaggtgatat tctcggcact gtatcatcag aacaaaaggt aaaagtcgat 899521 aggttcgtaa atgccgattg ggctcaaatt catttcaaag gaaagaaagc atatatttca 899581 actcactttt taatgaaaac cgcaagccaa gcgaaaacaa cgaaacagac agccttctat 899641 acaccgacgc ccgaaaacgg aaaagctaag cagctctcat ctggaacaga ggtgacaata 899701 cttgggtggg gattcagtga aaacggcgga tttgacttca cttgggcgtt cgtggattat 899761 ggcggagtta aaggctatat tcacacaaag gatttacaaa tgcgataaaa aggcaggccg 899821 aggcttgtct ttttgcctat gcatgaaaca tttcttcttt ctgcacgtaa caatgagaaa 899881 ggagatgatg atatgacggg tttagtcggc ggagggctta tgatcattgc gggcatactg 899941 atcaaactgt ttcctcccaa atcgatcaac agtgtgtacg gatacagaac gagacgctca 900001 atgtcagatc aaagattatg gaatgaagcg aaccgttaca gtgcatcatt aatgatcctg 900061 tcaggcttgg tgattgcggg aatgggtttg ctgctgggat caaacttgtt tattcttcag 900121 cttatcctgc tgattgccgc ctgtgtcata acatttatgc taacggagaa aaggctgaaa 900181 atcatgacgc acagtcaagg aggagataga agtggacgga gttaaatgcc agtttgtcaa 900241 tacgaacgga atcacgcttc acgttgcagc cgcaggacgg gaagatggcc cgttaattgt 900301 cctgctccat ggatttcctg agttttggta cggctggaaa aatcaaatca aaccgcttgt 900361 tgatgcgggt taccgggtca ttgctcctga tcagcggggc tacaatctca gtgacaaacc 900421 ggaaggaatt gattcgtatc ggattgatac attaagagat gatatcatcg ggcttattac 900481 gcaattcact gatgaaaaag caattgtcat cggtcatgac tggggaggag ctgtcgcatg 900541 gcatttggct tccacacgcc cggaatatct tgaaaaactg atcgcgatca atatcccgca 900601 cccgcacgtc atgaaaaccg taacgccgct ttatccgccg caatggctga aaagctcgta 900661 tatcgcatac ttccagctgc ccgatatacc ggaggcatca ctaagggaaa atgattatga 900721 tacattagac aaagcgattg gattatccga ccgtcccgcg ctttttacat ccgaggatgt 900781 cagcaggtac aaagaagcgt ggaagcagcc gggcgcgctg acagctatgc tgaactggta 900841 cagagccctc agaaaaggaa gcttggcaga gaaaccctct tacgaaacag taccttaccg 900901 aatgatctgg ggaatggaag accgcttttt gagcagaaag cttgcgaaag agacggaaag 900961 gcattgcccg aatggacatc tcatctttgt tgatgaagct tcccattgga ttaaccacga 901021 aaagccagcc atcgtcaatc agctgatttt ggaatatctt aagaaccaat aagctaaaat 901081 ttctctccat ccgtctgtca taatggcaga ctttttctgt gcgttttttt tcatagtctg 901141 ttttaaacat gacaaaataa cattaaaaat catgaatgtc accataaaat tgtaacaaaa 901201 aacaggttta aacgacttta aaaaaaggaa tagccttact gaagatttgt gtaaaactcc 901261 cctaaggcaa tacttaaaaa gaataataaa aagaaggtgc cttaatgaag caaggattaa 901321 tctcgattat tatcccgtct tacaatgaag ggtataatgt taaactcatt catgaatctt 901381 taaaaaagga atttaaaaac attcattatg actatgaaat attcttcata aacgacggaa 901441 gtgttgatga cacgcttcag cagatcaaag acttggcagc gacgtgcagc cgggtaaaat 901501 atatatcttt ttctcgaaac tttggaaaag aagccgcaat tttggcgggc tttgagcatg 901561 ttcagggcga ggcggttatt gtcatggatg ccgatctgca gcatccgaca tatttgctga 901621 aggaatttat caaaggctac gaagaagggt atgaccaagt cattgcccaa aggaacagaa 901681 aaggggacag ctttgtccgc tcactcttat catctatgta ttacaagttc attaataaag 901741 cggtggaagt cgatttgcgt gacggtgtcg gtgacttcag attgttaagc cgccaagctg 901801 tgaatgcact tttgaagctg agcgaaggaa accgcttctc aaaaggcctt ttttgctgga 901861 ttggctttga tcagaaaatt gtattttatg aaaatgtcga acgaaaaaac ggcacctcca 901921 aatggtcgtt cagcagtctg tttaactacg gaatggacgg cgtcgtttca tttaatcata 901981 agccgctgag attatgtttt tatacaggca ttttcatcct gctgctttcc atcatttata 902041 tcattgccac attcgttaaa attctgacta acggtatttc tgtgcctggg tatttcacca 902101 ttatctcagc agtgttattt ctcggcggag tacagctgtt aagtcttgga ataataggtg 902161 aatatatcgg ccgaatctat tatgaaacaa aaaaacgccc gcattatttg atcaaagagg 902221 cgaatatccc gaacaaagac ctgcctgaaa cgaacgaatt aaaaagcatg cggcgtctga 902281 caaaaatgca ctgaaaatac caagcgccat tggcagtgct ttttttgcgt gtctattatc 902341 ttaaaagcaa gactggagaa ttcatatgaa aagaaaacat atcatgatct atgcggccag 902401 tttgctggtg tccgttctgg cacacgcttt ttttgtgaaa gaatgggcgg aaggcaggta 902461 tatgacaggt ccgggtgacg ggcttgcgca aatgatcgta tttaaaaaat tattatttga 902521 ccaatataca cacgggaatt ttttctacaa ttattcattc ggacttggcg gcggcacatt 902581 cagtcagctc ggctattatt tttctgcgtc ttttcttttt cttgctgtgt ctgccgctgt 902641 ttggctgctt caagccgtcc agctgatcgg agaaacggat acgctttttt gggcagagtc 902701 agctgttttt atcagtattt tcaaattgag cttgatcatc tttacgtccg cttctgtttt 902761 tcattatctt cttaagcaca gggcggcatc gttcacggga gccgtgttat acggcgtctc 902821 aattatttat ttccgtcacg aagcgtattg ggaatttttc accgatacaa tggtttggct 902881 tccgctgctt gtgcttggcg cagaaaaaat tattagagag cggcgtccgg cgtggtttat 902941 cgttgcgtgt tcgctgacgt taatcaacaa tttttacttt gcatacataa accttatatt 903001 catcggaatc tatgtgctgt tcagatggct gatccgtttg gaaccacatg aagagaaaag 903061 atggattcaa atcagattat ttctcgtttc aggcttcatt tcttttggca tcagtgcggc 903121 ggcgtttgtg ccggtagtat acggtttttt aaacaacctg cgccctccat acagccagaa 903181 aatagagtgg ctcaatttcg atgataatat cttattttcg agccggatca tcattgtgcc 903241 ggccgctttt ctgctgtttt tgtttattat ttctttttac aaaaaccgtg tgtttcgtct 903301 ctttgccggg ttgagcctgc tgtttattct gtttcatttc agtccgtatg cggcaagcgt 903361 ctttaacggt ttttccgccc cgcaaaaccg gtttgaatat gttctggcct ttaccattgc 903421 gggagcagct gcggctggtt tgtcacagct gtctgaattg aaacggaaag aactgctccc 903481 ggccgcagct gtcgtcctgc ttctttactt gtatcatatc caaaggtata agctcgatat 903541 atggaagcct gcgaatgaaa gtattctatt gctcttactc atgacaatcg cagccttgtt 903601 tgctgcagct tttgcgaaaa aacgggcaaa aatggctgtg tacggtataa tcattctttc 903661 ttcgctgttt gtcgccaact cctatcaaaa atacgcgctc tcagaaggcg gcgatttgga 903721 cagtgtgaca aaagaatatc ttacaagtga ggaatacaga gggcgggaat catctgagct 903781 catcagacgt ttacagaagg aagacgatga cccgctcatg agaatcgact ggatgaacgg 903841 ggtccgcaat aatacgccaa tcatttacgg atttaatggc ttcagcgcgt attccagcat 903901 tttaaacaaa gatctgctgg ccttctattg gaatgattta agcatcgata tgggcaggga 903961 aagcgtcagc cgttacgcgt cattgggaga cagggcgaat ttatacagcc tgctttacgg 904021 caaatattat atgaccgaaa aaacaaacga agccagcgtc ccgtacggct tcaaaaagca 904081 tttagaaaca gagcattatg cagtttatga gaatcagtac atgcttccat tcgttaaaac 904141 agcggatgcc atatacagcg aaagtgagct ggaccgattg cccgctcttg cgaaagaaca 904201 ggcgatgctg aaaggaatta tattaaaaga tccatcagga aaaacggagc agacaccaaa 904261 accgtccaat ttgatcacca agtcggacat caccgcaaaa caagcccagt atcaaaacgg 904321 gctgctaacc gtaactggag aaaacggagg agagctgatc atcaccccga aacagccatc 904381 atccgctccg ggagactact atgtcagctt ttatttgaaa agcaaagcaa aagacaaagg 904441 atttacatta aaggtaaatg attatgtcac aacaaggaaa tcgaacaaat cgatctataa 904501 aaccggagta aataatataa cggtaagagt gcctaaatca ggccatatct caatcaatct 904561 tccgaaagga acctatgagc tgagaaacat agcgctctat gaagaaaatt accaaacgct 904621 gaaaaacgct gtaatgcaaa ataaaacaga gaaagcagac aaactgaatt ggaacaaaaa 904681 tcgactgacc ttttcctatc atctgtcaaa agaccagtac atcatgcttc cgatcccata 904741 tgaaaaaggc tgggagctga agatcaacgg aaaaacacag aagatcgaaa aagcggatta 904801 tgcttttata ggcttcaagg cgcaaaaggg agacaatcac attgagctga cttactatcc 904861 gccatacttc aaaatatcgg cgatcatatc tctcgtcagt ctgctgcttg ctgtttttta 904921 tataagacgt aaaaagcccg gctctatata gagccgagct ttaatttttt ctgaagtttt 904981 tcttcgctga atatccatcc cgtataggat gaacgaatcg tgagatcatg gccgatatga 905041 acaattgcga caaacggata atggcctttg ctccgataac gcaggtcgat aaatctcacc 905101 tcataatgat ctttaaacgt atccacttcc caccggtata ccggagaaaa ggacagaaac 905161 gccgcgatgt tatcatcctg ctttgccgca tgcattacat cggtttcagg aacaggcacc 905221 cgattaaatg tatccagaat cacgacatgt ccttccatgc ttcttcctac atagaaagca 905281 tgtgctgtcg tcactgcgat tcgccattgc ctgaatttca tcgttggaga aataataatg 905341 ctttcgatct catcatgaat catctcatga agcttccgtt taattctcag ctgcatgatc 905401 aggcgcacca agtagtagcc taccaatatg atatataagc tgagaaacgt gatgccggga 905461 ctcccgcctg cataccaaat cgcgatagct gccagatggc tgataaaaat aaacggatca 905521 aacgtattaa tcagcccgag cgcaacccat tttttcgaaa acggacgaat ggcttgtgtt 905581 ccataggcgt tgaatatatc aacaaagaca tgcagaacga ctgccagcag tgtccacagc 905641 cacaggtgca gaaaatcggc ctgaggataa aataaataca gaatcgccgg gatgatgaca 905701 gaccaaaaca aaacggcggg aattgaatgg gtaaatcctc tgtgattcct tatataaaca 905761 gcattgtttt taagctttaa cacagtatca atatccggag cctgagagcc cgcaagcgtt 905821 gcgatcataa cagcgtgagc cattgccgga tctgatccga caacaggatc aagcgtcgca 905881 ataccgccca gtgcgatgcc cataacgaca tgtgtgcccg tatccatagg tgacctcctt 905941 gcagggtgat cctgcacatt cactttgtaa gaaattcccc attttcatat acccaatttt 906001 taaactgatt caatcgttct catatgtttc cgctttttct ttattactat ttaatgtaac 906061 atattatcgt actgtgccct tagtgtacaa caaaaaacag tctaaagaaa agcggggcgc 906121 gaaagactgg ggagaaacac atatgaacgt acttgaagac aaattaaaac aaaaagacat 906181 acagcaattt cgcgatgatt taatctcatg gtttgaacga gagcagcgcg ttttgccgtg 906241 gagagaggac caagatccat ataaggtgtg ggtatctgaa gtgatgctgc agcaaacgag 906301 agtagagaca gtgattcctt actttctccg gtttgtagaa caattcccga cagtggaagc 906361 gctcgctgat gctgatgaag aaaaggtgct gaaagcatgg gaagggctcg gctattattc 906421 gcgagtcaga aacctgcaaa gcgcggtaaa agaagtgaaa caggaatacg gcggcattgt 906481 tcctccagac gagaaagatt ttggcgggtt aaaaggcgtc ggcccttata caaagggagc 906541 ggtgctcagc attgcctaca ataaacccat tcccgcggtt gacggaaatg tgatgcgtgt 906601 catgtccagg attctatcta tttgggatga tattgccaaa ccaaaaacaa gaacgatctt 906661 tgaagacgcc atacgagctt ttatttccaa agaaaaacca tctgaattta atcagggctt 906721 gatggagctt ggagccttga tctgtacgcc aaaatcaccc tcatgcctgc tttgcccggt 906781 tcagcagcat tgctcagcat ttgaagaagg cactgaacgg gagcttccgg taaaaagcaa 906841 aaagaaaaag cccgggatca aaaccatggc cgcgatcgta ctgactgatg aagacggaca 906901 agtgtatatc cacaaacggc cgtctaaagg tttgctcgcc aacctgtggg aattcccgaa 906961 tcttgaaaca caaaaaggga tcaaaactga gcgtgaacag ctcattgctt tcttagaaaa 907021 cgaatatggc atacaagctg atatcagtga tctgcaaggt gtagtcgagc atgttttcac 907081 ccacctggta tggaatattt cagtgttttt cggtaaagta aaacaagtgt cggataccag 907141 caagctgaaa aaagtaacga aagaagagct cgaacaattt gcgttcccgg tgtcacatca 907201 aaaaatctgg aagatggcag gagaagcagc cgccatctcg gctgctccgt aaaccattct 907261 taatcgtaag agacgcgcgt gccgtggctg tagtccgctt cattgcgctt cattccgccg 907321 cgcgcttcaa tttcttgcgt taattcccgg tattttgatt ggccttcttc gttcaaataa 907381 ggcataattt gctgaaaggc atgatgaaaa taagcgagtt cactgttctt ccaatctttt 907441 ttggaaacca tgttcaattc gctcatatca cgtccgacat acataacaga agaccccctt 907501 taaagttctt gccattattg tttgtggaaa taaaagaact atacgctaca aggagatgag 907561 gaaaaatgga acaaaataaa tgtgcactcg taacaggaag cagccgcggt gtcggaaaag 907621 cggccgcgat cagacttgct gagaacggct ataacatcgt cattaactat gcacgcagca 907681 aaaaagcagc attagaaaca gcggaagaaa tcgaaaagct tggcgttaaa gtgcttgtcg 907741 taaaagcaaa cgtaggacag cctgcaaaaa tcaaagaaat gtttcagcaa attgatgaaa 907801 cgttcggcag acttgatgtt tttgtcaata atgccgcttc aggagtacta agacctgtca 907861 tggaattaga agaaacacac tgggactgga cgatgaacat taatgcgaaa gcattgcttt 907921 tctgcgctca ggaagctgcc aagctaatgg agaagaacgg tggcgggcat attgtcagca 907981 ttagttcatt aggctctatc cgctatcttg aaaactacac cacggtcggt gtatcaaaag 908041 cagcgttaga ggctttaacc cgttatcttg ccgttgagct ttcaccaaaa caaattatcg 908101 tcaatgctgt ttcaggcgga gcgatcgaca cagatgcgct gaagcacttc ccgaatagag 908161 aagatctgct tgaggatgcg cgccaaaata cgccggcggg acgcatggtc gaaattaaag 908221 acatggttga tactgtggag tttctagtgt cttccaaggc tgacatgatc cgcggacaga 908281 caattatcgt tgacggcgga cgctcactgc tcgtttaaaa atttttaaaa aagaggaata 908341 gctatacgat cacctgcaca ttctaatgac cgtggaggtg ataacaatgg ctaactcaaa 908401 taacttcagc aaaacaaacg ctcaacaagt tagaaaacaa aaccaacaat cagctgctgg 908461 tcaaggtcaa tttggcactg aatttgctag cgaaacaaac gctcagcaag tcagaaaaca 908521 aaaccagcaa tcagctggac aacaaggtca attcggcact gaattcgcta gtgaaactga 908581 cgcacagcag gtaagacagc aaaaccaatc tgctgaacaa aacaaacaac aaaacagcta 908641 atcactgaaa cagaaaaaag cacttcatct tcgggtggaa gtgctttttt ctgtttgaaa 908701 aacgacaaaa cttgtggaag gtctacagaa tgagtcaaag ggtttgcttt atggagatcg 908761 aaatgattaa aggaggaaat gtttatactt tcatcaggct gaaggaggaa ccgatgaccg 908821 aatttgaaaa gctggtaagt gaacagatga aaacgatgga taagcttctc gatctccaat 908881 cagagctcga ccgctgcaaa caaattgagg cggaactccg gcatttggaa agggatgcaa 908941 ggctgcgtgg gattcaggct gaaattgcgg taaaacggaa acaccttgcc gatatacagg 909001 atatgtttca aaagcagaca gagcaggtca ttcgttcata tcgcagctca gaaaagccgt 909061 cttcctttgt gtagtgcagg aatgtgccat tccccggccg gaatggctct tttattttca 909121 tttttcaatt tgtaacgtta taataggtaa aagacgttgt cggtaagcaa atttggacat 909181 actaactgta gggctttata gaaagtaggg gagaaatatg ggctatccca aggaaggaga 909241 aaccattcaa attcacagct ataagcacaa cgggctgatt catagaattt ggaatgagac 909301 aacaatctta aaaagtacag aaatgtgtgt catcggagcc aatgaccgga cgatggtaac 909361 cgaatcagac ggccggacat ggataaccag agagcccgca atctgttatt ttcacgcaag 909421 acaatggttt aatgtcatcg ggatgctgag ggaagacggg gttcattatt attgcaacat 909481 cagttctccg tttgcctatg atggcgaagc aattaaatat attgattatg acttagatgt 909541 taaggttttt cctgacatga cctacaatat tctcgatgaa gacgaatatg atgatcatcg 909601 gaaagccatg aattatccaa aagaaatcga cagtatttta agagactact taaatacgct 909661 gctccattgg attcaccagc gtcagggacc gtttgcgccc gagtttgtcg atatgtggta 909721 tgaacggtat ttgcgctata caaaataatg gttacgtaaa aacctgttgc ggggtacaac 909781 aggtttttca catgggctca cacacatcat gataaagaga gagggggaat caaccgtggg 909841 ggttatgaaa cgctacatgc aattcgtcaa accttataag aagcaaattt tcgttacagt 909901 gttaatcggg atcgtaaaat tctccattcc gcttgctctc ccattgcttc tgaagtacgt 909961 agttgacgac attattcaag gaggcggcac ggccagtgac aaaaccacgt cattgttcac 910021 gattatggcg atcatgttcg ccttattttt aattttgcgc ccgcctgttg aatattaccg 910081 gcaatatttt gcccagtgga ctgccagcaa ggtgctttat gatataagag ctaagctgtt 910141 tgaccatata caaaaactga gccttcgttt ttacgcgaat acaagaacag gggaagtcat 910201 ttcccgagtg attaatgatg tagaacaaac aaaggatttc gtcatcacag ggctgatgaa 910261 tatatggctc gatatgctga cgattttgat tgtaatctct atcatgctca cactggacgt 910321 taaattaacg ctgatctcta tcgttttatt cccattatac ggaatatcag tgaagtattt 910381 ttacggccgt ttacgaaagc tgacaaggga gcgctcacag gctcttgctc aagtgcaggg 910441 gcatttgcat gaacgcattc aaggcatgcc tgtcatcaga agctttgcga tagaagatca 910501 tgaacaggct caatttaatg agaaaaacgg tcatttctta gataaagcca tccgccacac 910561 gaattggaac gcgaaaacct ttgcggtcgt taataccatt acagatttgg cgccgctcat 910621 cgtcatagcg tgcgccgggt attttgtcat taatggaccg ctgacagtcg gaacaatggt 910681 cgcgtttgtc ggatatattg acagaatgta caaccctgtt agaaggctga tcaattcctc 910741 tacaactttg acacagtcaa tcgcatcaat ggacagggtg tttgaattta ttgacgagcc 910801 ctatgaactc actgacaaac caaatgcgat aaaggccgat cagattcgcg gaggagtgga 910861 gtttcaaaac gtttcgtttc aatatgagaa ggacaaagaa aatattcttc atgatgtatc 910921 cttaaaagta aatagaggag aaactgtagc tctcgtcggc atgagcggag gaggaaaatc 910981 aacgctcgtc agcctgatcc caagatttta tgatgtaaca agcggcagac tgctgattga 911041 tgggacggat attcgcgatt atgaagcaag aagccttcgc aaccaggttg gtatggtgct 911101 tcaagatacc tttttattta gtgaaacgat tcgggaaaat atcgcgatcg gcaagcctga 911161 tgccacactt gaagagataa tcgaagccgc caaagctgca aatgcccatg aatttatcat 911221 gagttttcca gaaggatatg agacccgggt gggggaacga ggcgttaagc tttcaggcgg 911281 acaaaagcag cggatctcaa ttgcgcgggt attcctgaaa aatccgccgc tcctcatttt 911341 agatgaagct acatcagctc tggatttgga aagtgagcat tacattcaag aagcgatgga 911401 caaactggcg aaggatagaa caacttttgt tgtcgcccac cgtttatcga caatcaccca 911461 tgcggataag attgttgtca tggaaaacgg gacaatcatt gaaatcggaa cccatgatga 911521 actcatggac tatgagagcc aatacaagca cttatttacc attcaaaatt tgaactaaaa 911581 catcaatctt atatcctttt aacgaaggat ataagatttt tttgtatata aaaaaacccg 911641 gctgtttaac cgggttactc ttctgtttct atttcgcagt ctttcggatg atacgtttga 911701 aaacttgtga taagtgtttc taaatgttca agctgctcgc gatattccac ggcgcttgcc 911761 ataatattga gcatgttgta atcaataagc tcctcatccg tattctgctg attttttaaa 911821 aatgactttg ttaaaagctg cttataccgg atgccttctt caaccgcgtc atcatgcggc 911881 ttgatttttc cgacaaacct catcaaaatc cgctcgtgcc agtaaagcag gtaatcaagt 911941 tcttcagtca atgtttcctg aaactcttcc ggcatatgat agatctcgtt ttccagacga 912001 tgcagcttct tcaatgtatc aagcgcccga tttgcagtaa taatggcctg tctgaacagg 912061 acaagctttc ttgatttcac ataagtcgtt ttcttaaagt aacttctttc ttctttatat 912121 agaagatatg tctgatcaag cttgatcatt ttttctttca gtttttcaat atcctctttc 912181 aaaatcgaat gctctgtcga ctgccgcatg gacaatctga tccacttcat aatttcttcg 912241 gtgttttcga cggtattatg aatcagcttt gtttcgtact taggaggcaa aaacacaagg 912301 ttgacgataa aggaagaaag cacccctaag atgactgtgc ttgttctgat cagcgcgaac 912361 attaaaaagt cgtcaccggc agattctaat atcgcaatga ctgttacaag agcaattgaa 912421 attgtatgtt caattttaag tttcagcatg attgtaatga caataactgc tgttaacccg 912481 atcataatcg ggctgggtcc gaaaataagg ccgaacactg tggcaatcac agctccgatg 912541 atatttgctt gaacctggtc aataataatg agaaaagagc ggtaaatcga cggctggatc 912601 gcaaatatcg ctgcaattcc agcgaaaatc ggcgcgggaa gcccgatcca cgaagccaaa 912661 taaagggcaa gtgtaatcgc aatcccggtt ttgaaaatgc gggcaccaag tttcattggt 912721 ttgtgcgtgc attcctttct atagtaaatt gtgtgacata gcaaatgggc taatccttaa 912781 aattcccggt tagtttattt gctaaacaat taagtaatat acagggatcg atacaaatat 912841 tcaagctatt tttctagaaa aagaccaaaa tcttacacgc tgtttgattc cataaaaaaa 912901 caggagctca aagctcctgt tcaaggtatt tgattctagt tttttagatg tttaaatgca 912961 tcctcgaccg ctgtaagcgt gtctttaata tcctgctctg tatgtgctgt ggtaataaac 913021 caagcttcat acttagaagg tgctaaatta attccgcgtt ccagcatcag cttgaaaaac 913081 gtagagaatg tttctccgtc actccgttca gcctgctcgt aattttccac tttctcatca 913141 gagaagtata ccgtgagcgc accttttaac cggttgaccg taatggtgat gccgtgtgtt 913201 tctgcgtgct tcaaaatgcc ttcctcaagc atagcgccaa ggtgatcaag cttttcatac 913261 acgccttttt ctttgagcac ttccagacaa gcgatgcctg ataggatgga agcggggttc 913321 cctgccattg ttcctgcctg ataagcaggc cctagcggag ctacctgctc catgatttct 913381 tgtttgccgc cataggcccc aatcggaagt ccgccgccga taattttccc gagtgctgtt 913441 aaatctggtt tcacctgtaa gagatcctgc gcgccgccat acataaagcg gaaagccgta 913501 atgacttcat cgtaaataac gagagcccct gcattatgtg ttaattcatt tacttgttct 913561 aagaagccct ctttcggctc cacgataccg aagttgccga caatcggttc aacgagaacc 913621 gccgcgattt cactgcccca tttttcaaga gctgctttat agctatcgat atcattaaat 913681 ggtactgtga tcacttcgtt tgcaatgctt ttcggtacac cggctgagtc tggtgtgccg 913741 agagtagacg ggccggagcc tgcggcgaca agcacaaggt ccgaatgccc gtgatagcag 913801 cccgcaaatt taatgatttt tgtccggcct gtatatgcgc gagccacgcg gatggtcgtc 913861 ataacggctt ctgtacccga attgacgaat cttactttgt ccatagcggg aatggcttct 913921 ttgagcattt ttgcaaatgt aacctcgtgt ttcgttggtg ttccatacaa tacaccgttc 913981 tctgctgctt ttttaatcgc ttctgtaata tgcggatggg catgtcctgt aataatcgga 914041 ccgtacgccg ctaaataatc gatgtatttg ttgccgtcca catcccaaaa ataagcgccg 914101 cttgctttct ccattgcaac aggagaaccg ccgccgactg ctttatatga tctagacggg 914161 ctgtttacac cgccgacaat gtgctgtaat gcctcattgt gaagttcaat tgattttgta 914221 tgcaagaata aaaacctcct atatctccat gcgtcctttc tattgtagca tgcttccgaa 914281 caagaacaat ggcttcgggc ttcagattca gctgagatgg ttgtaatctg gacaagaatt 914341 ggatacgctt aataaaaaaa catccggagg taacgtaatg actatagaaa tcggacaaaa 914401 agcgcctgat cttgagttaa aaggtgatca tggggaaaca gtaaaattat cggattataa 914461 aggaaagtac atcgtgcttt atttttatcc aaaggacatg acaccgggat gtacaactga 914521 agcatgcgat tttcgggaca gtcacgaaag cttcgccgaa ctggatgccg tcattatcgg 914581 cgtcagcccg gacagccagg aaaaacacgg aaaatttaaa gagaagcata accttccatt 914641 tctgcttctt gttgatgacg agcataagct ggcggaagca tttgatgtgt ggaagctgaa 914701 gaaaaacttc ggaaaagagt atatgggaat cgagcgttcc acttttttaa ttgataaaga 914761 aggccggctc attaaagaat ggagaaaagt aaaagtaaag gaccatgtag ccgaagcgct 914821 tcaaaccctc aaagatatgt ctgaaaagta aatctctatg agcctatgct tacttttacc 914881 ctgatatcaa ttgacaaatt atcgtagaaa gagttacact aattataaac attacaatgt 914941 aagaattttt tttagaagag aggtgcatga cggatggctg cacatgaact aaaagaagcc 915001 ttagaaacgt tgaaggaaac cggagttcgc attactcctc aacgtcatgc gattctggaa 915061 tatctcgtta actctatggc tcatccaaca gcggacgata tatataaagc tctggaaggg 915121 aaatttccta acatgagcgt agcgacggta tataacaatt tgcgtgtgtt ccgggaatca 915181 ggtttggtaa aagagctcac atacggtgat gcttccagca gattcgattt tgtcacatcc 915241 gatcactatc acgcgatttg cgaaaactgc ggtaaaattg tggacttcca ctacccgggc 915301 cttgatgaag tggagcagct cgctgcccac gtcacgggct tcaaggtaag ccaccaccgt 915361 ttagaaattt acggcgtctg ccaagagtgt tcgaaaaaag aaaatcatta aaaataagct 915421 gaccgcacga aacggtcagc ttattttatt tcgacatttt ctttttatta taagactcat 915481 caaattcttt tccttctaat cccttatcta aagtcagcgg ctctcggcaa tgcatgcaca 915541 tatcgactac tcctaaaacc tttgtctctt tatcacagcc tggacaaatg acgcgaaccg 915601 ctttagtcga aagcattccg atccaaaagt aaactaccgt gctgagaccg atggataaaa 915661 gcccaagtat cataaacaaa ctagaaagca aaactgactc tttgaaaaag atcccgatgt 915721 acataatgat aaacccaacg aaaaccaaac ttaacgcaaa tgttctgatt ttattaattt 915781 tgctggagta tttcgccatg tccatccccc tctgttttaa ctatagcaca aacccgatgg 915841 gattttcttc atgttttcgg ttgaactgga atttacatat ggagagttac tgtgaaattg 915901 tttataatag ttcaatgtgt ttagaaaaaa ggaatttcgt tttaaccata gaattgaatc 915961 aaatagagaa taaaaaaatt tgaacaattg cattggagga atagtgatgg aaaatcttct 916021 ccgtccaatt taccaagaaa gagcaagtca ccccaataca ttggctgtca ttatgattga 916081 gagaagaaac aaaacatctt ccttaacaga taactttgat gcagctttgc tggtgattgt 916141 aaaggatgct gatgagccag tttttataaa gcattatgaa tttgatcatc aaacagcttc 916201 tttgcatgtg gtaacagatt ctcagattca agaatggatt ttgcttggaa caaatagaag 916261 aatcatagat tggattgtaa atggcagagt cttgtttgac cgtaatgaat acgtagttga 916321 actgattgac aggctgaata catttccgtt tgccgaacgt aaactgaaga tcggactcga 916381 atacggcaaa ttaatcagaa ggtatgttga agggaaagct ttttttgaag ccaatcaatt 916441 tttagatgcc tacaatgccg ttgttcatgc gctgcatcat ttagcacgta ttgaagtaat 916501 cgacagagga ttccatcccg aaaccacggt gtggagccaa gtgcgccaga tggagcccca 916561 agtgtacaaa ttatattccg agctgattga aagtcatgag agcctggaaa aaagacttga 916621 attattattc ttagcaaatg attttctcat ccattccaaa gccgagatcg gttcggcgca 916681 tcttttcgaa gtaatgaaag aaaaagacat ttggcaattc ggtgagcttc ttcaacatca 916741 tgacctaaag cactttaccc aagatcttgg cgttatgctt gattacttga cggaaaaggg 916801 acttatcaac gtctgccaga tagaaacgaa aggacaggct gtctatcacc gaggatattc 916861 ttttaaaaaa ggtgttgact ctgattcttg accgtgttat attattaaac gtcgctgatg 916921 cgcttctgag aaaacaagct cacagcggcg ggaaaataaa tcaaaaaaac atttgacaaa 916981 agaaagtcaa aatgttatat taataaagtc gcttcaacaa gaagtgaaaa tgatctttga 917041 aaactaaaca agacaaaacg tacctgttaa ttcagttttt aaaaaatcgc acagcgatgt 917101 gcgtagtcag tcaaactagg gcctgcacga cgcaggtcac acaggtgtcg ccgcaggatg 917161 cggtgaactt aacctgtgat ccatttatcg gagagtttga tcctggctca ggacgaacgc 917221 tggcggcgtg cctaatacat gcaagtcgag cggacagatg ggagcttgct ccctgatgtt 917281 agcggcggac gggtgagtaa cacgtgggta acctgcctgt aagactggga taactccggg 917341 aaaccggggc taataccgga tggttgtttg aaccgcatgg ttcaaacata aaaggtggct 917401 tcggctacca cttacagatg gacccgcggc gcattagcta gttggtgagg taacggctca 917461 ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg ccacactggg actgagacac 917521 ggcccagact cctacgggag gcagcagtag ggaatcttcc gcaatggacg aaagtctgac 917581 ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta aagctctgtt gttagggaag 917641 aacaagtacc gttcgaatag ggcggtacct tgacggtacc taaccagaaa gccacggcta 917701 actacgtgcc agcagccgcg gtaatacgta ggtggcaagc gttgtccgga attattgggc 917761 gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa gcccccggct caaccgggga 917821 gggtcattgg aaactgggga acttgagtgc agaagaggag agtggaattc cacgtgtagc 917881 ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa ggcgactctc tggtctgtaa 917941 ctgacgctga ggagcgaaag cgtggggagc gaacaggatt agataccctg gtagtccacg 918001 ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc cttagtgctg cagctaacgc 918061 attaagcact ccgcctgggg agtacggtcg caagactgaa actcaaagga attgacgggg 918121 gcccgcacaa gcggtggagc atgtggttta attcgaagca acgcgaagaa ccttaccagg 918181 tcttgacatc ctctgacaat cctagagata ggacgtcccc ttcgggggca gagtgacagg 918241 tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg 918301 caacccttga tcttagttgc cagcattcag ttgggcactc taaggtgact gccggtgaca 918361 aaccggagga aggtggggat gacgtcaaat catcatgccc cttatgacct gggctacaca 918421 cgtgctacaa tggacagaac aaagggcagc gaaaccgcga ggttaagcca atcccacaaa 918481 tctgttctca gttcggatcg cagtctgcaa ctcgactgcg tgaagctgga atcgctagta 918541 atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcac 918601 accacgagag tttgtaacac ccgaagtcgg tgaggtaacc ttttaggagc cagccgccga 918661 aggtgggaca gatgattggg gtgaagtcgt aacaaggtag ccgtatcgga aggtgcggct 918721 ggatcacctc ctttctaagg atattatacg gaatataaga ccttgggtct tataaacaga 918781 acgttccctg tcttgtttag ttttgaagga tcattccttc gaaacgtgtt ctttgaaaac 918841 tagataacag tagacatcac attcaattag taatacaaga tatcacatag tgattctttt 918901 taacggttaa gttagaaagg gcgcacggtg gatgccttgg cactaggagc cgatgaagga 918961 cgggacgaac accgatatgc ttcggggagc tgtaagcaag ctttgatccg gagatttccg 919021 aatggggaaa cccaccactc gtaatggagt ggtatccata tctgaattca taggatatga 919081 gaaggcagac ccggggaact gaaacatcta agtacccgga ggaagagaaa gcaaatgcga 919141 ttccctgagt agcggcgagc gaaacgggat tagcccaaac caagaggctt gcctcttggg 919201 gttgtaggac actctgtacg gagttacaaa agaacgaggt agatgaagag gtctggaaag 919261 gcccgccata ggaggtaaca gccctgtagt caaaacttcg ttctctcctg agtggatcct 919321 gagtacggcg gaacacgtga aattccgtcg gaatccggga ggaccatctc ccaaggctaa 919381 atactcccta gtgaccgata gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg 919441 aaggggagtg aaagagatcc tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg 919501 gtgatggcgt gccttttgta gaatgaaccg gcgagttacg atcccgtgca aggttaagca 919561 gaagatgcgg agccgcagcg aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag 919621 acccgaaacc aggtgatcta cccatgtcca gggtgaagtt caggtaacac tgaatggagg 919681 cccgaaccca cgcacgttga aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa 919741 tcgaacctgg agatagctgg ttctctccga aatagcttta gggctagcct caaggtaaga 919801 gtcttggagg tagagcactg attggactag gggcccctac cgggttaccg aattcagtca 919861 aactccgaat gccaatgact tatccttggg agtcagactg cgagtgataa gatccgtagt 919921 cgaaagggaa acagcccaga ccgccagcta aggtcccaaa gtatacgtta agtggaaaag 919981 gatgtggagt tgcttagaca accaggatgt tggcttagaa gcagccacca tttaaagagt 920041 gcgtaatagc tcactggtcg agtgactctg cgccgaaaat gtaccggggc taaacgtatc 920101 accgaagctg cggactgttc ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc 920161 cagaccggaa ggactggtgg agcgcttaga agtgagaatg ccggtatgag tagcgaaaga 920221 ggggtgagaa tcccctccac cgaatgccta aggtttcctg aggaaggctc gtccgctcag 920281 ggttagtcgg gacctaagcc gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt 920341 cctgtaccac ctcctcacca tttgagcaat ggggggacgc aggaggatag ggtaagcgcg 920401 gtattggata tccgcgtcca agcagttagg ctgggaaata ggcaaatccg tttcccataa 920461 ggctgagctg tgatggcgag cgaaatatag tagcgaagtt cctgattcca cactgccaag 920521 aaaagcctct agcgaggtga gaggtgcccg taccgcaaac cgacacaggt aggcgaggag 920581 agaatcctaa ggtgatcgag agaactctcg ttaaggaact cggcaaaatg accccgtaac 920641 ttcgggagaa ggggtgctct gttagggtgc aagcccgaga gagccgcagt gaataggccc 920701 aggcgactgt ttagcaaaaa cacaggtctc tgcgaagccg taaggcgaag tataggggct 920761 gacgcctgcc cggtgctgga aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt 920821 gaagccccag taaacggcgg ccgtaactat aacggtccta aggtagcgaa attccttgtc 920881 gggtaagttc cgacccgcac gaaaggcgca acgatctggg cactgtctca acgagagact 920941 cggtgaaatt atagtacctg tgaagatgca ggttacccgc gacaggacgg aaagaccccg 921001 tggagcttta ctgcagcctg atattgaatg ttggtacagc ttgtacagga taggtaggag 921061 ccttggaaac cggagcgcca gcttcggtgg aggcatcggt gggatactac cctggctgta 921121 ttgaccttct aacccgccgc ccttatcggg cggggagaca gtgtcaggtg ggcagtttga 921181 ctggggcggt cgcctcctaa aaggtaacgg aggcgcccaa aggttccctc agaatggttg 921241 gaaatcattc gcagagtgta aaggcacaag ggagcttgac tgcgagacct acaagtcgag 921301 cagggacgaa agtcgggctt agtgatccgg tggttccgca tggaagggcc atcgctcaac 921361 ggataaaagc taccccgggg ataacaggct tatctccccc aagagtccac atcgacgggg 921421 aggtttggca cctcgatgtc ggctcatcgc atcctggggc tgtagtcggt cccaagggtt 921481 gggctgttcg cccattaaag cggtacgcga gctgggttca gaacgtcgtg agacagttcg 921541 gtccctatcc gtcgcgggcg caggaaattt gagaggagct gtccttagta cgagaggacc 921601 gggatggacg caccgctggt gtaccagttg ttctgccaag ggcatcgctg ggtagctatg 921661 tgcggacggg ataagtgctg aaagcatcta agcatgaagc ccccctcaag atgagatttc 921721 ccattccgca aggaagtaag atccctgaaa gatgatcagg ttgataggtc tgaggtggaa 921781 gtgtggcgac acatggagct gacagatact aatcgatcga gggcttaacc atatttttga 921841 atgatgtcac acctgttatc tagttttgag agaataagtt tttcaaaaaa acacttgatt 921901 ttctcaagaa tacatagtat aatgttaaat gtcactgaaa ttgtctggtg atgatggcga 921961 agaggtcaca cccgttccca tgccgaacac ggaagttaag ctcttcagcg ccgatggtag 922021 tcgggggttt ccccctgtga gagtaggaca tcgccaggca gacttcattc cgcagtagct 922081 cagtggtaga gctatcggct gttaaccgat cggtcgtagg ttcgaatcct acctgcggag 922141 ccattattgg agagctgtcc gagtggtcga aggagcacga ttggaaatcg tgtaggcggt 922201 caactccgtc tcaagggttc gaatcccttg ctctccgcca ctgatactta tacataatta 922261 caattgaaag tctgggcccg ttggtcaagc ggttaagaca ccgccctttc acggcggtaa 922321 cacgggttcg aatcccgtac gggtcattat atgatggagg attagctcag ctgggagagc 922381 atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc attatatcat 922441 cgcggggtgg agcagttcgg tagctcgtcg ggctcataac ccgaaggtcg caggttcaaa 922501 tcctgccccc gcaaccaaat tttaaaatgg tccggtagtt cagttggtta gaatgcctgc 922561 ctgtcacgca ggaggtcgcg ggttcgagtc ccgtccggac cgccatttga atacttaggc 922621 tcggtagctc agttggtaga gcaacggact gaaaatccgt gtgtcggcgg ttcgattccg 922681 tcccgagcca ccacctatgc cggtgtagct caattggtag agcaactgac ttgtaatcag 922741 taggttgggg gttcaagtcc tcttgccggc actgtttttt caaaatttaa tgtggagggg 922801 tagcgaagtg gctaaacgcg gcggactgta aatccgctcc ctcagggttc ggcagttcga 922861 atctgccccc ctccaccatt tataggggca tagtttaacg gtagaacaga ggtctccaaa 922921 acctccggtg tgggttcgat tcctactgcc cctgccaaat ttatgacatc ttgagattat 922981 ggcggttgtg gcgaagtggt taacgcacca gattgtggct ctggcactcg tgggttcgat 923041 tcccatcaat cgccccatat tatcattggg ctatagccaa gcggtaaggc aacggacttt 923101 gactccgtca tgcgttggtt cgaatccagc tagcccagtc tcacttttta tatcaactgc 923161 atataatgta ttaagtccat taaaaatgcg gaagtagttc agtggtagaa caccaccttg 923221 ccaaggtggg ggtcgcgggt tcgaatcccg tcttccgctc caattacggc ggcatagcca 923281 agtggtaagg cagaggtctg caaaaccttt atccccggtt cgaatccggg tgtcgccttc 923341 ttattgccgg ggtggtggaa ttggcagaca cacaggactt aaaatcctgc ggtaggtgac 923401 taccgtgccg gttcaagtcc ggccctcggc accaatttta cttacatggt aagttgaatt 923461 ggtgtttgtg ttttatcatt ataactaatc atattaatga tctacataag tagatcattt 923521 ttttaatgct ttgatttatc ataacaagtt aagttccgag gcctattata aagcggctgt 923581 atagctagtc tttcaacact tttattttat atttccataa aaactttttt gaaatacgtt 923641 gacactttat gagatccatg atatatttat attcgtcggt tagatacgac gtaaaacttg 923701 ccggtgtggc ggaattggca gacgcgcacg actcaaaatc gtgttccttc tggagtgtcg 923761 gttcgacccc gaccaccggt atactgaaaa acccgtttct taacagaaac gggtttttat 923821 tttttattaa agaaaaggag cctcggctcc tttttatact tactcagcgt attggtctag 923881 gatctcttct agcacctctt ctagctcttc tgtatcttca agctctgatt ggctgaaacg 923941 gacgcgtaca agctgttctc cgtcattata catctcttcc aaccaccctc ggagtcctct 924001 tgctctgcgg tcgacttcga aaatgatttc caaaccgtct tcgtctaaaa ggaaaatgag 924061 ctctaattca tcaagcatct gacgataata tccggaagtc ggaacgaatt cgaattcttg 924121 aacgaacgga agacgacgct ggaagtaggg cgcttgttcg cagtctgctt cgttaagacg 924181 gaagcccagg ttttcgattg cttcaagcac attttcaatc caagggtgcg cttcaacgaa 924241 aatgcggtca tgatcggatt tatcgatacc gccttgaatg tcaaggtctg tcaccacggc 924301 aacctctact ttccctacag tgatcggcgt atctagaggc agagtgaatg tgaacggaaa 924361 ttgatgctct tcaccaggct gtatggtaaa tgaaccagtg acccggaaag aatgaattgt 924421 agcgtatttc cggtgctctt catcgtcttt tacaatgaca taccgtgtgc taagctgtaa 924481 atcgatataa cggatgtcct gagcgatttt tccgcctttg acatgtaccg ttccctgtac 924541 ttcttctcct ggaaaatatg cgtctttttc taaaattgta tctacttttg cagctccaat 924601 tccggcactt gccgcaagct tcttaaaaaa tgacatgtta gatcttcccc tttttctttt 924661 ttctcaacag atatacgtaa gaaggaggaa aaaagattcg tttgattcat acttttttcc 924721 tattattcgt ctcggcctag ggacagacta agaataatat tgaaaataaa ggagtcgatg 924781 gaagtgaata aagaaagttt ggttgcagat gaattacaca gaatgttttt ggctggtgag 924841 ctgcaaatca cagtagagga ggatataaac aatatttccg aaaggctgag aaacggcgat 924901 ctcagtttag accgattaag cggtgaagac gtgtttataa aagaaacggt aaatgaggct 924961 ttaagaagag tggagcaata aaaaagagac ggcatctcat ctttgagatc ccgtctcttt 925021 ttgtggtctt tgctgtaaga taaaagcgaa tcgatttgga attgctcacc cgagccaccc 925081 cttttctaac agaagatctg acagttcatc atggagataa acagctgtat ctaattgatc 925141 atgcaatgct cttctgatgt ggggattttc ggttgctgtt gttgcgacag tgtatttgtt 925201 aatgctggtt tttattgttg ttaacaaatc aagaatatct ttgggacaaa gactttgttc 925261 aatgggaaac cacctccttt gtttttttag cagctcctga taagaaagta tttgactttg 925321 tttcttgctt ctatacaaaa tgctataata agcaacaaat tttgttgggg ggtgtgatga 925381 tgaagcagat tattgcgatg gggggcgggg gtttttcgat ggagccggat aatttgtccc 925441 tcgatcaata tatcctcaat caatcaaaac gagagcagcc tcgtatttgt tttttgccga 925501 cggcgagcgg agattcccaa aactatattc agcggtttta tcatgcattt caaacattgg 925561 attgcgtgcc gtctcattta tctttgttta agccaccatc atcagattta gtttcttttg 925621 ttatggaaat ggacgtgatt tatgttggcg ggggaaatac gcggaattta cttgtgttat 925681 ggaaagagtg ggggctggac catattctca gggaagcatg gaagaacggt gtggttgtag 925741 ctggaataag tgccggtgcg atctgctggt ttgaagaagg ggtgacagat tcagccggac 925801 cgctgacaag tttgaaaagt ttaggttttt tgcaagggag cttttgtccc cattatgacg 925861 gggaaaagga tcggagaccg gcataccacc agctgatatc taacaagttc ttatgcagtg 925921 gctatgcagc ggatgatggg gctgctctcc atttcataaa tgatcagctg tttcagactg 925981 tgagttcaag gtcgggtgca aaggcatatc gggtgatgat ggctgaacat gaaatagctg 926041 aaatcccgtt gccggtcaaa tatttagggt gaaattggct gaatattatc tatattcctc 926101 tttttttcag attgatttta tgataagatg agtgcgaaat caatagttac tgggggtgcc 926161 cgctttcggg ctgagagaga aggcaagctt cttaaccctt tggacctgat ctggttcgta 926221 ccagcgtggg gaagtagagg aattgttttt gttattgtct tgctgggcaa taatatgttt 926281 ctttctgact gtaaccgggt tcatttatat gaatccggtt ttttgtgctg gttatgggct 926341 tgattttgtc ctttcaaacg tagaaagggg aaggaaaagt aatgcaaaac aattcagtgc 926401 agcaagccaa catttccatt atgtcaagtt tttcaggcag caagaaggta tacgtggagg 926461 gttcttcttc ggacatccaa gtgccgatga gggagattgc attgagtccg acgacgggat 926521 cgttcggcga agaggaaaac gcgcctgtgc gtgtctatga tacaagcgga ccgtatacgg 926581 accctgaagt aaccattaat attcaagaag gattaaagcc gctccgccaa aaatggatca 926641 cagagcgcgg tgacgtggaa gagtatgaag gtcgggctat aaaaccagaa gataacggtt 926701 ataaaaaagc aaaaccaaac gtaagctatc caggattaaa gcggaaaccg ctgagggcga 926761 aggcaggtca aaatgtcaca caaatgcact atgcaaaaaa ggggatcatt acacctgaga 926821 tggaatttat cgccattcgt gagcatgtgt ctcctgaatt cgtcagagac gaggtagcca 926881 gcggccgggc gattattcct tcaaacatta atcaccctga aagtgagcca atgattatcg 926941 gccggaattt tcatgtgaag attaatgcaa atatcgggaa ttcagcggtt acgtcatcca 927001 ttgaagaaga agtggaaaaa atgacgtggg ccatccgctg gggagcggat acgatgatgg 927061 atctctctac cggaaaagat attcatacga cgcgtgaatg gattatccgc aattgccccg 927121 tgcctgtggg aactgttccg atttatcagg cgcttgaaaa agtaaacggc gtagctgagg 927181 atttaacgtg ggagatttat cgtgatacgc taatcgagca ggcagagcag ggagtggatt 927241 attttacgat tcacgcgggt gttttgctta ggtatgtacc gctgactgcc aaacggacaa 927301 ctggtatcgt gtcacgcggg ggagcgatta tggcgcagtg gtgtctggct catcatcaag 927361 aaagcttttt atacacacat tttgaagaaa tatgtgagat tatgaaaatg tatgatattg 927421 ctttctctct tggggatggt ttgcgtcccg gatcaattgc tgatgccaat gacgaagcgc 927481 agtttgctga attagagacg cttggagagc tgacgcaaat tgcctggaag catgatgttc 927541 aggtgatgat tgagggtcct ggacatgttc cgatgcataa aatcaaagag aacgtcgata 927601 aacaaatgga catttgtaaa gaagcgcctt tttacacatt ggggccgttg acaacggata 927661 ttgctccggg atatgaccat attacttcag cgatcggagc ggcgatgatc ggttggtacg 927721 ggacagcaat gctttgttat gtaacgccga aggagcattt ggggctgcca aaccgtgatg 927781 atgttcgtga aggagtcatt acatataaga tcgctgcgca cgctgcggac cttgcaaaag 927841 ggcatcccgg agcgcaaatc cgggatgatg cgttatcgaa agcccgtttt gaattccgct 927901 ggcgggatca gtttaattta tctcttgatc cggagagagc ccttgaatac catgatgaaa 927961 ccctgcctgc tgaaggagca aaaaccgctc acttttgttc catgtgcggt ccgaaatttt 928021 gcagcatgag aatttcacag gatattcggg attatgcgaa gaaaaacgat ctcagtgaag 928081 cagaagccat aaataaagga ttaaaagaaa aagcaaaaga gtttgtcgat acgggaagca 928141 atttatatca ataaaaaaaa tgaagatgga gaatgctcca tcttcatttt tttagaaaaa 928201 cagagagcgt cgaagcggag gaatactctg ttcaaagcgg aaaacatttt ctggatcata 928261 tgtcgttttg acacggcgga gtcgttcaac gttttcgccg taatatgttc ttggccagtt 928321 tctgatttcg atatctggcc aatttacgta gtctcccatc gtttctttcg aaagggacgt 928381 tctcagcccc tcaatccagc ggacattttg tcttttttct ccaggggatg tccagtttgt 928441 taagtattcc tgggcgatga ttgcgtcacg ataataaaat gccgtttggt cgggagcgac 928501 ccgtccggct gccccgccga gtgcttgctg ccagacactg gcgttttgat tcggagcgtg 928561 ctctaaaaag tgttttattg ttgagatcgc acgttctgat aatggctttt caatgaaaga 928621 gccggagcgt ttcatttttt gaggctgatt gcctcccggg ctgttaaaaa aggttaccgc 928681 ttcaatgaat ggcgttgttt ttaccattcc gcttgtcgga cttcctgctt tcaataaagg 928741 ctttaacagt ttttttaact ctgtttttgg cccgacaaat tggccgaggg cttctatgcg 928801 gtttacttct ttaggccaaa actctattga tgatgtaagc cggtcatctg tatacggggc 928861 ccagttctgc cacgtgttat atacttcctc aaaatcatcc catccccatg taatagaaaa 928921 aatcgacact tgagagatgg gcactgcttt aaatgtcatg gaggtgacta tgccgaaatt 928981 gcctcctccg cctccctgag acgcccaaaa taagtctgga tgatttgaac agctgactgt 929041 aatcagatca gcgccctctt tttcgtctgc tacgatcatc tcaagctgca cgaggctgtc 929101 gcaagtaaga ccggcagccc ttgttaaaag tccaattccc cctccgagag ttaaacctgt 929161 gagccctaca ttagcaatgg tgcctgcggg aagcgtcagg ccgtattgcc agagtgtccg 929221 atagacttct cccaattcag cccccgcttc aatataggcc agctttttat cctgattcac 929281 agttattttt ttcatctcgc ttaaatcaat aacaagaccg ttatttaaaa gggaaaagtt 929341 ctcatagctg tgtctgccgc ctctaatacg gaaaggcaca cggttttcac gcgcccattt 929401 cagcgcattg agtgcatcct gtttgttttg gcaaaacaca atgatgtcag gatacctttc 929461 taagcttagg ttaatattgg ttcttgcttc gttatagtcc ggatcatccc gtgtcacgat 929521 acgtccggtc aattttgtct tttccacact cccacatctc tttctctcgt attctagttt 929581 ctctagctta tgcgtcaggg gaaaagagtg tataaggaaa aagcggggat gcaatctgat 929641 acagtgtcaa caccctcaaa aaatagttga caggtcggta ttgtatgaat taacatggtc 929701 agtacaaatt tttcaaattt atcgcgctga tcggaacacc gaaggctctt atcgtttaga 929761 taagggcctt ttttgtatga aaaagggggg attattgatg ggagtcaaaa aagaaaaggg 929821 gagaaaacga ttcaggaagc gaaaaaccta cgggaatcag attttgccgc ttgagctgct 929881 gattgaaaaa aacaaacgag agattataaa cagcgcggaa ctcatggaag aaatttatat 929941 gaagattgat gagaagcata cgcaatgtgt aactaaatat aaaaaaaccc gctgactaca 930001 acgggttttt gcatttctcc attaagaatc ttttttaatc ggcaatccaa ggccttctgc 930061 cacgcgtttt ccgtattcag gatccgcttt gtagaagtgc tcgatttggc gcagcttgat 930121 ttcttctttt tctaccggct tcatggcatt aacgatattt tcaacaaggc gggtacgttc 930181 atcttcactc attaaacgat acagatcgcc ggcttgagtg tagtgatcgt agtgatcgta 930241 gcttacgctg tcagcgatac cttgtaccgg atatgctgct tgcttatcct caggtgactc 930301 ttttggaccg ccgaagctgt taggctcgta atacacagat ccgccgccgt tatcatcaaa 930361 acgcatttgc ccatcacgct gataattgtt tactttgttg cgtgcgcggt tgattggcag 930421 cgcttgatgg tttgcaccga cacggtagcg gtgtgcatca tgataagcaa aaagtcgacc 930481 ttgaagcatt ttatccggtg aaacatcaat accaggcacg agggttccag gtgaaaatgt 930541 cgcttgttct acctctgcaa agtagttttc cggatttctg tctagaacca tgcgtccgac 930601 ctcgattaac gggtagtctt tttgagacca aacttttgtg acatcaaacg gatcgaaacg 930661 gtacgtattt gcatcttcta aaggcatgat ttgcacatat agtttccatg caggataatc 930721 accgttttcg attgcgttga aaaggtcttc tgtatggtaa tcagggtttt caccggcaat 930781 ttttgctgcc gtattgacat caaggttttt cacgccttgt tctgttttaa agtgatattt 930841 aatccatacg ccttcgcctt cggcatttgt ccatttgaat gtatggcttc cgaagccgtg 930901 catgtggcga agtgtcgcag gaattccgcg gtcagacatc aggattgtca cttggtgcag 930961 tgactctggt gaaagtgacc agaaatccca tacagccgta gggtttttca ggtgtgtttt 931021 tggatctctt ttttgtgtat ggatgaaatc agggaactta atcgcatcgc ggataaagaa 931081 tacaggcgta ttgttgccga cgatgtcgta gtttccttct tcagtataaa atttaacagc 931141 aaatccgcgc gggtcgcgaa ctgtgtcagc agagccaagt tcaccggcaa ctgttgagaa 931201 acggatgaac aacggtgtgc gtttgccgac ttcagaaagg aaagcggctt tcgtgtattt 931261 tgttacgtcg tttgtcactt caaaatatcc gtgtgcgcct gctcctttgg cgtgaacaac 931321 acgttcagga acacgttctc ggttgaaatg ggccaatttt tcgagtaaat gtacatcttg 931381 aattaaagtt ggtccgcgag aaccggcagt cattgagttt tgattatctc caaccggagc 931441 gccccagcta gttgtcagtt tatttgaact catgttatca cctcttggaa tttataagaa 931501 cataatatca tctctaagta aaaagtcaat attattttat aattattata aaatagttat 931561 ctctattaat cgatatatag tatcgaaatt gttgaaaaac cttgttgtaa cagcttttta 931621 tgacacttaa taatttttgg agaaataatt tttccttctc tatttgcgaa acaagcagag 931681 taagtgataa acaaggatat caaaaatcgt atttaaaaaa gagttgacat atcggaataa 931741 tttgaattaa catgttattc aaacaaaaaa acaattgggc agctgatcgg accgccgaag 931801 gctctcatct ctacaagaac agagatgggg gcctttttgt tttttttgaa ggcggggttg 931861 gcagaaagag agggataaaa gtggctgtga ccatcagcat caaagaaaag gcatttgttc 931921 aagaaggccg caaaaacacg gtcttagaaa acatagaatt atcaatcgca ccaggcgaat 931981 ttctaacgct tatcggaccg agcgggtgcg gaaaaagcac cctgttaaag attattgcag 932041 ggcttgattc tgaatatgac gggagtgtgg aaattaacgg ccgcagcgta acagctccgg 932101 gtattcagca aggatttatt tttcaggaac accgcctctt tccttggctg actgttgagc 932161 agaatattgc agccgacttg aatttgaagg acccaaaagt caaacaaaag gtggatgaac 932221 tgatcgagat tgtcagattg aaaggatcgg aaaaagcata tccgcgcgag ctgtcaggcg 932281 gcatgtcaca aagagtagcc atcgcccggg ccctgctgcg ggagcctgag gtgctgcttt 932341 tagatgaacc gtttggtgca ctcgacgctt ttacaagaaa acacctgcag gacgtgctgc 932401 tggatatatg gaggaagaaa aaaacaacga tgattctcgt gactcatgat atagatgaat 932461 ctgtttattt aggaaatgag cttgcgatcc ttaaggccaa accggggaaa atccataagc 932521 tgatgcccat tcacctggcg tatccgcgaa accggacgac tccggatttc caagcgatca 932581 gacagagagt gctgtcggaa ttcgagaaaa cagaagattt ggagtacgca gaaggatcag 932641 ggatatagaa agggcggaag cggaaatgaa aaaaggactc attgtattgg ttgccgttat 932701 ttttctgctc gcaggctgtg gagcaaatgg agccagcggt gaccacaaac aattgaagga 932761 aattcgtatt ggtattcagc aaagcttaag cccccttttg attgcaaaag aaaaaggctg 932821 gttcgaagat gcatttgaaa aagaaggcat caaagtgaaa tgggtggagt ttcaaagcgg 932881 tccgccccaa tttgaaggcc ttgcggcaga caaacttgat ttttctcaag tcggtaattc 932941 gcctgtgatc gctggacagg cggcaggcat tgactttaaa gaaatcggtt tgtctcagga 933001 cggcttgaaa gcaaacggca tccttgtcaa tcaaaacagc ggcattcaag acgttaaggg 933061 cttaaagggg aagaaaattg cagtcgccaa aggcagcagc gggtttgatt ttttgtataa 933121 agcgcttgat caagtggggt tgtcagctaa cgatgtgaca attattcagc ttcagcctga 933181 tgaagcagct tccgcatttg aaaacggatc tgttgatgcc tggtccattt gggagccgta 933241 cttgtcctta gaaacaatga aacacggagc aaaaatcctt gtgaacggag aaagcacaga 933301 tttatattca ccgggtttta ctttagtaag aacaaagttt tcagaagagc atccagacga 933361 agtggtccgt tttctgaagg tgtttaataa agccgttgta tggcaaaagg aacatctgga 933421 tgaagcagcg gacttatatt ctgacattaa agatctcgat aaaaaggtcg tcgaaaatgt 933481 gctgaaaaat actgagccac ttaatgagat catcagtgac gacattgtga aagcacagca 933541 ggaaacagca gattttcaat ttcgaacaaa ggcgatagat aagaagattg atgtgaagga 933601 tgttgtcgat aacactttta tcaaaaaagc attagaggag cattcctcag gaggtgatca 933661 atgatgaaag cagaggctgc gggctcgctg cccaaaacga atgcggaagc ggtgcgaaaa 933721 aagcccggaa ggaagagata cggctggatg aaggggcttt tactgcccgc tgtcatcatt 933781 gccatctggc aggtcatcgg cgggctgggg gttgtgtccg ctacagtgct gcctacacct 933841 gttacgattg ttctgacctt taaggagctt attttgtccg gcgaactgtt cggccatctg 933901 caaatcagca tttatcgggc ggcacttggt tttttgcttg gcgcggggct tggattgatg 933961 atcgggattt tggccggatt ttccaaacgg acggagctgt atcttgatcc gtcgttgcaa 934021 atgcttagaa ccgtacctca tctggccgtc acgccgctgt ttattttatg gttcggattt 934081 gacgaagtat ctaaaatttt gctgattgcg ctcggtgcct tctttcctgt ctatatcaat 934141 acgtttaacg gcatccgcgg ggttgacgcg aagctgtttg aagtcgcccg ggtgcttgaa 934201 tttaaatggc atcagcagat atccaaagtg atattgccgg cagccctgcc caatatattg 934261 ctaggcattc gcttatcgct cggcattgca tggctcgggc tcgttgtggc agagctgatg 934321 ggctcaagct cgggagtcgg ctatatgatc atggatgcga gacagttttc acaaacgaat 934381 aaagtctttg cagggattat catttttgca gtggttggaa agctgacgga ttccttcgtc 934441 aggctgcttg aacgaaagct gttaaagtgg agaaacagct acgaaggata aaagatataa 934501 aggggagatg aatatggaaa ttctttggtt tataccgact catggagacg cgagatattt 934561 aggatctgaa agtgatggac ggactgcgga tcatctttac tttaaacaag tcgcgcaggc 934621 ggcagacagg ctgggatata caggagttct tctgccaacg ggaagatcgt gcgaggaccc 934681 gtggcttaca gcgtcggcac tggcaggaga aacaaaggac ttaaagtttt tagtcgcggt 934741 aagacctggt ttaatgcagc cttctctggc agccagaatg acatccaccc tagaccgcat 934801 ttcagacggc cggctgctga tcaacgttgt ggcagggggc gatccgtatg agctggcagg 934861 cgatggcctg tttatcagcc atgatgagcg ctacgaggca acagacgaat ttttaaccgt 934921 ttggcggaga cttttgcagg gagaaacggt ttcctatgaa ggaaagcata taaaagtgga 934981 aaacagcaat ctgcttttcc cgccgcagca agagccgcat ccgcccatct atttcggtgg 935041 ttcgtcacag gctggaattg aagctgccgc aaagcataca gacgtgtact tgacatgggg 935101 tgagccgcct gaacaagtaa aagaaaagat agaaagagtc aaaaagcaag cggcaaaaga 935161 agggagatcc gttcgatttg gcattaggct gcatgtcatt gcccgtgaaa ctgaacaaga 935221 ggcatgggaa gcggcagagc gcttgatcag ccacttggat gatgacacca ttgccaaagc 935281 gcaggcagct ttgagccgtt acgactcttc aggccagcag cggatggccg tccttcatca 935341 aggcgatcgg acgaagcttg aaatcagccc gaatctgtgg gcggggatcg gcctggtcag 935401 aggaggggca ggaacagctc ttgtcggtga tccgcagacg attgccgacc ggatagcgga 935461 gtaccaggca ctcggcatag aatcgtttat attctccggc tatccgcatt tagaagaagc 935521 gtattatttt gcagagcttg tatttccgct tttgccgttt gaaaatgatc ggacgagaaa 935581 gcttcagaac aaaaggggag aagcggtagg aaacacttat tttgtcaaag agaaaaatgc 935641 atgagtttaa ctaaaataca gccccccgaa catggtatga tattcaaaaa aagggggctt 935701 tttttctgaa aacattgaga agcgcggcag tcatttgcct catagctatg ctgtcagcat 935761 gcggacattc aaaacagatg gaaatcaaag cggcggacat atcagatctt gaaaaaaaca 935821 gaatggatgt cgcagcttca caggcattca ctgccgaagc cgtcaatatc ggtgaaggta 935881 tttcttcagc tgacatgtac atcgaacatt atcaaaaggg aaagcttgtt gagaggtttg 935941 gaccggttcg tgcagattat tcagaggaaa aaactgatac catacaattt gtttattttg 936001 agaatgaaga gggggaagga aagaataaac ataccaccat tcattttggc attgtggata 936061 aacagggaac tatagcggct gattcatcgg tgaaacgcga cgatagcaca acacaggaaa 936121 tgactcagaa tatttcatcg ccggaaccga ttactttcga gaagcctgct ttgatcggca 936181 gcagtattag agggactgac gagacaatgc acacctctga acataaaaaa gagctcatta 936241 agcatcaaga tgcgttactg tattatgtgg aattgcatca ttagaatggg cggcttcagg 936301 ccgtctgttt tacaaagcgg tatgcttgct tttttgaatg gtgaatgata cattttaaat 936361 cgtaacaatt tcgatttaaa gggaggctat gtgacttggc taaaaaatca aaagtggcaa 936421 aagagttaaa acgccaacag cttgttgagc aatacgctgg tattagacgc gagttgaagg 936481 aaaaaggaga ttacgaggca ctcagcaagc tgccaagaga ttcagcaccg ggaaggcttc 936541 acaaccgctg catggtaacg gggcgcccga gagcatatat gaggaagttt aaaatgtcca 936601 gaatcgcttt cagggagctg gcccataaag gccagattcc cggtgtgaaa aaagcaagct 936661 ggtaagaaaa aactccggcc gattacagcg cgccggagtt tttttcgttt ttcttgaaag 936721 agatgacgta ggaaaggtgc tggatgatca tgatgataaa cacaataata atagggaaaa 936781 acggaatgcg cgattgaaat agcggataaa aaatgagaag aaccgctgcg gcaggcagcg 936841 agaagtagac agcgatatat gacgcgcgac atgcttttgc cgtcatcatc tgctctcttt 936901 catcctgctc ttcaaactca tcaggcagaa gtagctgctt tctggcaggg cggctttttt 936961 tctgtaagta caaataaacc gcagacgccg caacaaacag aataaaggga gtgaggttta 937021 aatcaaatac catcccgccg ctctttgtgc cgaaaaaaga tgctatgcct tctgaggctt 937081 caaagtatga aatcagcgcc cagcatgcaa ggccaaataa aacaaggtga aaagctgctt 937141 ttgttttcat gctcatctta gttttcctcc tctaaccaaa agacatcctc cattttcatg 937201 gagaaggctt tgcagatttt cagtgctaac agcagtgagg gaacataatc gcctttttca 937261 atcgctgcca cagtctgtct tgtgacgccg accgtttctc cgagtttttc ctgagaatag 937321 ccgaagcgtg ccctcagctc ttttacttta tttttcatca tgacgtctgt ccccttcaca 937381 atctcgattg attatattgt atagtatact taacattatg taaatggaac ttaacaactt 937441 tacaaaaaga taactttttt tcgacaaaat ttttatattc ccttgacgaa aaataaataa 937501 acatgtaata taaaaaaagt cagagcggta ctgttgctga caatcacaaa tgcgggtgta 937561 gtttagtggt aaaacctcag ccttccaagc tgatgtcgtg agttcgattc tcatcacccg 937621 ctccatacat acgttattaa cgcagtgttt cgtttctcag ataaacgaag tattgcgttt 937681 ttttatgtga aaaagaacac ggtattcgtg ttcttttacg taagccaatg tactgtatgg 937741 gtgccgccgt gaatttgttc aaacattttc gttaatgatg ataagaggtt aacagcgctg 937801 cttttctcaa tcgatggcgg gaaaaaaatg atttgcagca tattcttagt ctcgtttgaa 937861 acgggatagt ggttgacgct gtttttgaaa tcgccaaaaa tgccgttttc atcagagaaa 937921 agcagtatgt tttctttttc tcccaatgag atccggaccg gctcatgaag ctttccggca 937981 tcataaatca taataggcag agaatatttt aatgcgaaaa aatcgattgt gtcatgggcc 938041 gagtctttac tttccatgaa ttgttccttg gatatcggga ccagcatgtc ctccattggg 938101 gttgtttctc cctcaaatga agggttaagc tgtttaaaga gtttctgcca ttccttgacg 938161 aaggattcat cggatatacc gccgtccgca tagtcgaaaa acaaggattc ttgaaacagg 938221 cggagtctgc ctttcagcat ttgcggtgag gagccgactt cgatattctc ataaatgaca 938281 gcagctgcat gtaagccggc cgcacgttca gtaataacag aatcaagttt gatattcact 938341 agcattcact ccagttacgt gatatcaacc tattataaac gctgtgtcgt tttatcacaa 938401 agaaaggagg ctgtgcaaaa catgaacgtt tatcagctca aagaagaatt aattgaatac 938461 gcgaaaagca ttggcgtaga caagattggt tttacgaccg ctgatacttt tgacagttta 938521 aaagaccgtt tgattcttca agaatcactc ggctatctct ccggctttga agagccagat 938581 atcgaaaaaa gggtgacgcc gaagcttctt ttgccgaaag cgaaatcaat agtggcaatt 938641 gctctcgcat atccttccag aatgaaggat gcgccgagaa gcacgagaac tgagcgcagg 938701 ggcatttttt gcagagcttc ctggggaaaa gactatcatg atgtgctgag ggaaaagctt 938761 gatctgctgg aggattttct aaaaagcaag catgaggata tcagaacgaa gtcaatggtt 938821 gatacaggtg aattgtctga tcgcgccgtt gcggaacgtg ccggaatcgg attcagtgcg 938881 aaaaactgta tgatcacaac acccgagtat ggctcttatg tgtatttggc ggaaatgatc 938941 acaaatatcc cttttgagcc tgatgtgccg attgaagata tgtgcgggtc ctgcacgaaa 939001 tgcttggacg cctgcccaac gggagcactg gttaatcccg ggcagcttaa tgcgcagcgc 939061 tgcatctctt ttctgaccca gacaaaagga tttttgcctg atgaattccg gacaaaaatc 939121 ggaaaccgcc tgtacgggtg cgatacgtgc caaacggtat gccctctcaa taaagggaag 939181 gattttcatc ttcatccgga aatggagcct gatcctgaga ttgccaaacc gttattgaag 939241 ccgcttttgg ccatcagcaa tcgggaattt aaggagaaat tcgggcatgt ctcaggttct 939301 tggcgcggaa aaaaaccgat tcagcgaaac gccattctcg cgcttgccca ttttaaggat 939361 gcttccgcac tgcctgaatt gacggaactg atgcacaagg atccgcgtcc tgtcatcagg 939421 gggacagccg catgggcaat cggaaaaatc ggagaccccg cctacgcgga agagcttgaa 939481 aaagcgctgg aaaaagagaa ggatgaagag gcaaagctgg aaattgaaaa aggaattgag 939541 ttgctaaaag cttcaggcat gactaaacaa ggcctgtcct gacatacgta tagagcagaa 939601 ggaaaaaaca cttgagatca tccaagtgtt ttttctctat aaaaaagtat ggcgggtggg 939661 gtgagcttga agtacatttt agaacaatta gcggaggagc ggctgggctt tctggttaac 939721 gggcatgcta tgagacagga gtctcaagtc ggagacctta aagtcatgga gcgtaagaaa 939781 aagcttctgg aaaaacgtaa agttgacatc ataaaagcga aagcaaaggc cgtgattaat 939841 catgtgcggg ttgaggatga cggaacgacc tgcctttcgt ataccatcca ttacgaatac 939901 gtgtgtaagg aacaagatga cagcttgtat atagaagagc acatagagga gcgaatggct 939961 ttcctgtatg atcacatttt gattagtgat caggaaattg cgaaaaagcc ggctggattt 940021 catgaaggga ccagtattat tgactattct gaagctgaag aggaaagaga agcgtttggc 940081 agggcttttc aatacgatcg tctcggcgct gtccaatatg ccgagaaatt ttggaacaag 940141 cgcaatcctg cttataaaaa tttcagcgat aactgtacaa attttatttc tcagtgtctt 940201 catgcaggag gcgcgccgat gcgcggtcat ccgaacaggg gatcaggctg gtggatgaaa 940261 caaagctcat ggagctacag ctggacggtg gctcactcta tgaaaatgta tttgtcgaat 940321 tcaaaggccg gactgcgtgc ggtgcgggtg aaatcagcgg aagaactgat gccgggcgat 940381 gtgatttgct atgacttcga aggagacggc cggtttaatc atacaacgat tgtcgtggca 940441 aaggacaaag gcaatatgcc gcttgtcaac gcccagactt atgacagcag gatgaggtat 940501 tggtcatatg aggattctac ggcatacacg ccgtcaatac gatatgcctt ttttcatatc 940561 gttgatgata cgacaaaaga gtaattaatg ttataatgat gggcggataa gaaaaacaga 940621 ggtgaacatt gtggcattac atgtcgtttt atatcaacca gaaattcccg ctaacacagg 940681 gaatattgca cgtacttgtg cagcaaccaa tacaacgcta cacctgattc gtccgctcgg 940741 cttttcaacg gatgataaaa tgctgaagcg tgccggactc gattattggg agtttgttaa 940801 cgttgtgtat catgattcgt tagaagaatt gtttgaggca tataaaaaag gcaagttttt 940861 ctttattaca aaatttggcc agcagcctca tacatcattt gattacactg atcttgacga 940921 ggattatttc ttcgtgttcg gaagagaaac aagcggtttg ccaaaggatt taattcaaaa 940981 taatatggac cgctgcctgc gtcttccgat gacagagcat gtcagatcgt taaatctgtc 941041 caatactgcc gcgattcttg tttatgaagc gctgcgccag caaaattacc gtgatttaaa 941101 atagtgaaaa acccgctcat cgatgatggg cgggtttttt tgcggatgtt gaaatgcttt 941161 gtttcgtttt tgggcttaac aacgtaacag tgttatgtta caatgtaccc atcaaaggag 941221 ctggacttat ggaagaacaa ttaatctcta aaaaagaatt acttgaaaga acatcgattt 941281 catacggtca gctgtatcga tggaagcgga aaaacttaat acctgaggaa tggtttattc 941341 gtaaatccac atttacaggg caagagacgt tttttccgag agaggagatt ttaaaacgta 941401 tatcaatgat tcaaaagatg aaagaaaatt tgtctttgga tgaaatgagg gaaatgctgt 941461 cgccgaaaat gaaggatgtc agcatgaccg ctgatgaatt gcttcataaa ggtttggttt 941521 caaggcctgc tcttgaagcc tattcagaag acggaggaag tccggttttt tcatccagcg 941581 atttgctttc gctgtttgtg cttgagggcc tgctgcagtc tggaaatgtc agccttgcag 941641 aagcaaaaat ggctgcagag gtattaaaga agcatgatac tgaagagatt gaaaaacaga 941701 cggagctgat tgtgctccgc aagctcggtg tcacaacttg ttttatagcg gctgcggcgg 941761 acagcatttt gtttgaatca tccgtaaagg ttgtggaacg ggtagattta ttaaaagctt 941821 cagaggaatt aaaaacaaca tttatgcagg agggccatca atggatgtag tggaaaagct 941881 ggtgataaat ggatcaggaa gttctaaggg aggaacattt caatcagttg agattaatgg 941941 cagcgggaca gtggccgggg acgtggagtg tgacactttt tcttttaatg gaaacggaaa 942001 agcggacggc agcgtcaaag cgaaagcggt aactatcagc ggttcaggaa agatacatgg 942061 agacgttgaa gcagaatcta tccggatgaa tggcactggt tttattcaag gagaggtatc 942121 tgcaaaacaa ttgaaaatcg ctggatcatc aacatttggc ggcactgtca aggctgatgg 942181 aattgacatt agcggaaaag ctgtcatgga agcagattgt gaaacagaaa cctttcaatc 942241 agaagggaaa tgcaaaatca gcgggctttt aaatgcagac caggtgatca ttaagctttc 942301 tgcaggggaa agctatgcgc gggagatcgg ctgccgccat cttcaagtga cctgcagaaa 942361 aggaatgctg acattgctca gattgatgcc gcagcctgtt ctaacagcag agctgatcga 942421 aggtgacgtg attgaattga caaatacaaa ggcgaaaacc gtgcgcggta ataaagtgat 942481 catcggcccg gattgccaga ttgaaaccgt cgaatacagc ggggactata cctgtgatcc 942541 aagcgcgtcg gttgaaacat ccacaaagtt gtaaggagga tcgtaatgga gacaacaaaa 942601 ctgggaaatt taaaattata tggcgctggg catgccgcag gaggcgcgta tcacaatgtc 942661 agcatcaaag gagaaggtat agttggagaa gggctgtctg ctgtaggctg ccgcatatac 942721 ggaacgggcc tttttctcgg aaaagcagag actgagcggc tgcgtgtgct cggagaaagt 942781 gaatgtaaag gcgatctgac agccggcaaa atcaatatat atgggacaat gaaagtcagc 942841 ggctcacttc aatttgatcg attcaatctg aaaggccaga ctgaaattgg cgggaatatg 942901 actggagaat cctgcgatgt gaaagggaag cttagcgtaa taggtgattg tgaaacagaa 942961 atgttccatg tcacaggctg tgttgatgta tcggggttat taaattcggg tgagatcaag 943021 ctgggattga gccatgatat aagccatgtg caggaaatcg gcggaacaac aattacagtg 943081 aaaagacgcg cgagtttttt tagccggaag aaagggaagc tgatcgccga tgtcatagaa 943141 ggagatcggg tttatttgga gaataccgaa gcggcagttg tcaggggaaa agaagtgatc 943201 atcgggccgg gatgcagcat cggaacgatt gagtacgaat acaaatgtga atgcgatccg 943261 cattcacaga ttaaagaaaa aacaaaactg taaaacattg ttctgttata caaaaagggt 943321 gctctttcag gagcaccctt ttttattctt ttccaggctt gctttcgtat cctgcggtaa 943381 aaattgatac taaaaaagtg acaatgacac ccatcatgat gattgttttc accgtctctc 943441 cccctcttca atttttccgt gctgtccgag tctggatgat tctgtatttt tctttattat 943501 gaacggtcgc agtctgcctt gtcaacgatg tatgagtatc tttattttta agaaaccaaa 943561 gcatgtatca cgagatggcg gcatagattg tatcaaagta ccttatttgc atagtgtatc 943621 aaacatgata gaggaggtcc ttatggatat attaaagaaa attgaaaagt acagagagga 943681 agagcagcgg ctgaaatggg aaggaacttt cgccgattat ttggagatta ttaaagaaaa 943741 tccgatggtc gcgcaatctg ctcattctcg agtttttaat atgataaaag acagcgggat 943801 agaggagatt gacggacgca agaagtacag tttttttgac cgcgagctgt tcgggcttga 943861 agaatctctg gagcgtcttg tggaagagta ttttcatccg gctgccaaac gtctagatgt 943921 cagaaagcgg attctattgc tgatggggcc tgtgagcggc ggtaaatcca cgctggtcac 943981 aatgcttaaa aaaggtctcg aagcgtacac gctgacagat aatggcgctg tatatgcgat 944041 taaaggctgc ccgatgcacg aggaccctct acatttaatc ccccatcatt tacgcgatga 944101 cttttacaga gaatacggca ttagaataga aggaagtctt tctcctttaa atgtcatgag 944161 gctggaggaa gagtacggag gaagaattga ggatgtgaag gtggagcgca tcttcttttc 944221 agaagataag cgtacgggaa ttggaacatt cagtccctct gatccgaaat ctcaggatat 944281 tgccgatttg acggggagta ttgatttctc aacaatcgcc gagtacggtt cagaatcaga 944341 tccgcgcgct tatcgatttg acggagagct gaataaagcg aaccgcggga tgatggagtt 944401 tcaggagatg ctgaaatgtg atgagaaatt tctctggcat ttgctttcct tgacacagga 944461 agggaatttt aaagctgggc ggtttgcgtt aatttctgct gatgagctga tcgtggctca 944521 cacgaatgaa acggagtatc gctcatttat ttctaataag aagaatgaag ccctgcactc 944581 aagaatcatc gtgatgccgg ttccttataa tttaaaagtg tctgaggaag agagaattta 944641 tgaaaaaatg attgcagaaa gcgatgtggc ggatgttcat attgccccgc atacgttgaa 944701 ggtcgccgcg atgttctcaa tccttacccg gttaaaagag ccgaagcggt cggatattga 944761 tctggtcaag aaaatgagac tgtatgatgg ggaaagtgtg gaaggatata actctgtcga 944821 cgttgaggat atgaaaaaag aatataatga tgaaggcatg agcggaattg atccgcggta 944881 cgtgatcaac cggatttctt caacgattat cagaaaaaat atggaatcga ttaattctct 944941 cgatgtcctt cgctccttaa aagaaggtct tgatcagcac ccatcaattt caagcgagga 945001 cagggagcgg tatttgaatt ttatctctgc cgcccgcaag gaatatgacg atattgcgaa 945061 aaaggaagtt caaaaagcgt ttgtttattc atatgaagaa tcagcaaaaa cacttatgga 945121 caattacctc gataacgtag aggcctattg caataaaaac aagcttcgtg atcctttgac 945181 aggagaggaa atgaaccctg acgaaaagct gatgagatcc atcgaagagc agatcggcat 945241 ttcggaaaac gccaaaaaag cgttccgcga agaaatttta atccgcatct cggcctatgc 945301 gagaaaaggc aagcggtttg attacaattc ccatgaaaga ctgcgtgaag ctattcagaa 945361 aaagctgttt gctgatctga aggatgtcgt taaaattacg acctcaacaa aaacgccgga 945421 tgagcagcag ctgaaaaagg taaatgaagt cgtggcccgt ttaattgatg agcacggcta 945481 caactcgacg agcgccaatg agctgctgaa atatgtcggc agcctgctga accgataagc 945541 aacgtgaccc gtccgaatag ggcgggttat tttgtcccat tttctaaata gtttgtcaat 945601 taaacgtgca tatgtgcata tgatgaatat aaatcttttc aaaagacttg tttcataatc 945661 tggcacaagc cggaatacgt atgtatcacg accacaaatg gttaaggagg ggaattcatg 945721 tcccaaaatg acagcggcca ttttttgatt tctgaggaaa actggtccct ccatcgcaaa 945781 ggcttcgatg accagcagcg ccaccagaaa aaagtgcagg aagcgatcaa aaacaatctt 945841 ccggacctcg taactgagga aagcattatt atgtctaatg gaaaagatgt agtgaagatc 945901 ccaatccgtt cacttgatga gtataaaatc cgttataact atgataaaaa taaacatgta 945961 gggcaaggag acggcgagag ccaggttgga gatgttgtgg cccgggatgg atcagacaaa 946021 aaacaagggc ctggaaaagg gcagggtgcc ggtgatcagg caggcgagga ttattatgaa 946081 gcggaagttt cattaatgga tttagaagaa gcgcttttta aagaattaga gcttccgaat 946141 ctccagcaaa aagagcggga caatatcatt catacagata tcgagtttaa tgatatccgt 946201 aaaacagggt taaccggtaa tattgataag aaaagaacga tgatgtcagc ctttaaacga 946261 aacgcaatgt caggaaaacc gtcgttctac ccaatttatc cggaggacct gaaatataag 946321 acgtggaatg acatcacaaa gcccgaatca aaagccgtcg ttttagccat gatggataca 946381 agcggcagta tgggggtttg ggaaaaatac atggccagaa gcttcttttt ctggatgacc 946441 cgttttttgc ggacaaaata cgagactgtg gaaattgaat ttattgccca tcatacagaa 946501 gcaagagtgg tctcggagga ggattttttc tcaaagggag aaagcggcgg aacaatttgt 946561 tcttccgtat atcggaagtc gcttgagctt attgatgaaa agtacaatcc cgcccgctat 946621 aacatttacc cgtttcattt ttctgacggt gacaacctga catctgataa cgcgcgctgt 946681 gtgaagctgg tcaatgatat tatgaagaag gccaatctgt tttgctacgg cgaggtcaat 946741 cagtacaaca ggcattcaac gttaatgtct gcatataaaa atgtaaaaga tgagaaattt 946801 aagtactata ttttaaaaca gaaatctgat gtttttcagg ctctaaagaa ctttttcaga 946861 aatgaagagt ctggtgtaag ccatcaattt tcgtaatgaa aagcccattt cagggctttt 946921 ttttatttaa taaaagcaag aaaacgcttg cgaaaaaaat acgggagaaa aagaaatttt 946981 tcctttgaca aatcttcttt catttattaa tattttatct tgtgaactat tattgaggaa 947041 tgaggtgaaa aggagttgac tgaatcagaa cgtgctttgc tcacttttga acagctcttc 947101 gatacgtctc gggcgatata taaaaaacag aagaagatat tggagattgt gcttgagcct 947161 tttgatatta cagtccttca atatttgctg atgtttaaaa ttcatcaaag cggaagcacc 947221 ccgctaagca agctggcaat gtcgcttgat cttaagcctg cttctgtgac gcggatgaca 947281 gatattctgt ataagcgcca attgatgaat cgatatgaca gtccggatga ccgccgtatc 947341 gtcatgattc agttaaccga agagggggaa gaactgatag aaaaagccgc tgtgcaatat 947401 gcaaaaatgg gtgctggctt gtaccaaaag cttgatacct cccagctgca gtatttgcgc 947461 aaactagccg gaagtttaac gaagcttgct gaaggctgtt cagaaaaaag cggtaattaa 947521 aaacttctca catattttca ccagctttcc gcaaaatgat agaggatgaa acgaaaggag 947581 aaaacaaaat gaacagagga cgtttaattc tgaccaacat tatcggtttg attgttgttc 947641 ttgcaattat agctggaggt gcttactact attatcaaag cacaaactac gtaaaaacag 947701 atgaagcaaa agtagcgggc gatatggctg ctattactgc tccagcagca ggtaaagtat 947761 ctgactggga tctggacgaa ggaaaaacag tgaaaaaagg cgacacagtt gcaaaaatca 947821 aaggtgaaca aactgttgac gtaaaatcca ttatggatgg cacaattgtg aaaaacgaag 947881 tgaaaaacgg acaaaccgta caagctggta caacaattgc acaaacgatt gacatggaca 947941 acctatacat cacagcaaat attaaagaaa cagatattgc ggatattgaa gtaggaaata 948001 gtgtagacgt agtagttgac ggagaccctg atactacatt tgacggtact gtagaagaaa 948061 ttggttatgc gactaactca acttttgata tgcttccttc tacaaattca agcggaaact 948121 acacaaaagt aacacaaaaa gttcctgtga aaatttcaat caaaaaccca tctgataagg 948181 tgcttcctgg aatgaatgca tctgttaaaa tttctgagta aaacagatca gtcatcaaac 948241 catgaaagga ggttgtctta gatggctaca ggcaaagaaa aaaatgcaaa aaaccctatg 948301 tcattgctga ttgtgctaat ggcgggttta tttttggcaa ttctaaacca aacactgctt 948361 aatgttgcaa tgccgcactt aatgactgaa tttggcgtaa gtgcaacgac gattcagtgg 948421 ctgacaacag gttacatgct tgttaacggt gtattgattc cgttatctgc tttcctgatt 948481 acacgatttg gccagcggag tctctttctc gtcgcgatgt tttgttttac gctcggtacg 948541 ttagtctgcg gtatcgcacc taacttctct acaatgctga tcggccgttt gattcaggcc 948601 gtgggcggag gtatcttgca gccgctcgtt atgacaacca ttctgttaat tttcccgcct 948661 gaaagcaggg ggaaaggaat ggggattttc gggctagcga tgatgtttgc tccagcggtc 948721 ggcccgactc tttccgggtg gattattgag cattatacat ggcgcattat gttttacgga 948781 cttgtgccga tcggcgcaat tgttatcatt gtggctttct tcatctttaa aaatatggtg 948841 gagccgcaaa aaatcaaact cgatactctt ggcgcaatcc tctcgattgt cggattcgcc 948901 tccttattat acggagtcag tgaagccgga tctgacggct ggaccgaccc gattgtattg 948961 tctacagtta ttatcggagc cattgcaatt gttgcttttg ttgttcagca attgcgtcat 949021 gatgatccga tgcttgattt cagagtgttt aaatatgaca ttttctcact ctcgagtgtc 949081 attaatatca ttattacagt ggcactttac actggtatgt tccttttacc gatttatctg 949141 caaaacctgg tcggctttac ggcgcttcaa tccggtctgc ttctgcttcc gggtgcgatc 949201 gttatgctga ttatgtcacc gatctcaggt attttgttcg ataaattcgg accgagaccg 949261 cttgcgatta tcgggcttct cgtgacagtg gtaacaacgt atcaatacac gcaattgaca 949321 attgatacac catatacaca catcatgctg atctattcaa ttcgtgcatt tggtatgtct 949381 ctcttaatga tgccagtcat gacagccggg atgaaccagc ttcctgcccg tctgaacagc 949441 cacggaacgg cgatgagtaa cacgcttcgc caaatcagcg gatcaatcgg aacaagttta 949501 attacgacga tttatacaaa ccggacgaca ttccattatt cacaaattgc agataaaaca 949561 agcacggcgg acccgaactt cctccatgcg ttccaaaatg cagtttcgaa tttaatggtg 949621 aatatgaatg tgtcttatga tacggcgaaa acatatgtgt actcacatat ttataaacac 949681 gcatcactcg attccaatgt catggggata aatgatgcct ttatgtgggc aaccttattc 949741 tgtgtagcag gtttgatttt aagtatcttc ctgcgtgacg tcagaaaaga taaattgcgt 949801 aagaagaaaa aagaggagct ttcattactt cctgctccaa aagaagctaa ggaatcttaa 949861 tctgtacagg gaggtttcct gaatgaaaat ttatgtagtg tatgatagtg aaggcgaaca 949921 tactaaagtg cttgcagaag cgattgctga aggcgcgaga gaaaacgacg cggctgaagt 949981 gttcatcgac catgtagatc aggctgatat ccgcaagctt aaagatatgg atgcgattat 950041 ttggggatgc ccagggcatt tcggaacaat cagctccggt cttaaaactt ggatcgacag 950101 acttggctac ttgtgggctg aaggcgagct gatcaacaaa gtcggtgctg tcttctgcac 950161 aacggcaaca acacacggcg gcttggaaat gacaatgcac aatttaatca cgccgatgtt 950221 ccaccaaggc atgattgttg tcggactgcc tggcaacgtg cctgaaaacg cactttatgg 950281 ctcttattac ggagcaggtg tcacttgtcc ggtagacagt gatgagttaa tgtctgagga 950341 aggtattcag cttggacgcg cgttgggaag acgtgtcagc caagtcacag gaaacctaac 950401 agcaggacag taaggagagg ttgaaatggc cattattata gcaataattg ctgctgtcat 950461 tgtcattgcg gcccttatta catttaacgt ccgcaacgcc tcacctggac ctgagaagca 950521 agaagcaacc gatagaatcg cacctccaga agaggaaaaa aacgaagcgc attaccctgc 950581 tgaagcaagg gctgccgagc atacgccatc cgttgtcaaa aacgattctc caaaagagaa 950641 gcgtgacaca atgggtgatg atatttacag gcaggcgctg caaaagttta agcattctga 950701 tgaagttcat gcagaagaag aggtcactga ggaaagtgac aaaatgcagg accgcagcta 950761 tcgtgatgcg ctgctctcta tgaaaaataa gaaaaagtaa tgaaaaaggc aaatccgttt 950821 actcatgcgg gtttgccttt tttgctgttt ccatcaatta tgtttttatc aaataaatcc 950881 atggaatatg ttgtattcca ccttgatcta gtgtactatg ttactcatac accgaggatt 950941 ttttccggga ggtaaagaca tgaattcttt tttaggttta ttaaagaaag atatcaagct 951001 ttcaagaatg tggctgctag tatggatatg cggaatcatt ttcttattgg gaacaggcca 951061 tattatagct tctcgcacga aagaacctct agtcattttt ggtttttttg ttgcagttgc 951121 tttttttctg cttttcttat ctcctgtttt tgttttttat caccttcgca aggaagggaa 951181 atcacagctt tggctgtaca atccaaatgg cggcttatgg ctgttttctt ctaaattggc 951241 agcatctttg ctctatcaat ttgtgattca gttggcatta acagcctatg gcatatggat 951301 gtatcatatg ctctctgtaa aaaatctgct ggagcatcaa gttgatataa cgagtacagt 951361 ggctttgctg aatatgtatg ggcttatttc ttcgttagat atgtcagtaa cagtcattgt 951421 gttttggact gtttttcact ctctcagaaa ttggcgcgga atgcggtggg ctgcgatggt 951481 tctgttggtc gcaatgtggt tattcttcga tgaatacatc ataagccctt tggttgaatc 951541 tcaaaagcat ttctggcctg taacagtcta ttgcaatttt gatttccact tccacaatgt 951601 ttggagattg gaactaaaac ctatccatct gtctgtgcta gggtttccta ttgctatagt 951661 catcacattc ttgctgctca tcatggcttc aaaactgctt gatcgtaaag tagaggtgta 951721 aatatggaca atcaattcca atcctcgaaa ccgatttatc tgcagatcgc tgatcagatc 951781 ttttataggc tggtcaggaa ggagctgctc ccaggagaca agcttccttc agtaagagaa 951841 atggcgattc aaactaaagt aaatcccaat acaattcaaa gaacttacag tgagatggaa 951901 aggctgggta ttgtggagac aagaagaggt caagggacgt ttattgcgga aaaagcagaa 951961 atcgtagacg agctgaaaga caagctgaca cgagaggtgc tggaaggctt tgtcaagcaa 952021 atgaaagagc tggggctaac gaaagaagaa atgttagaag ggattaaaac attcacagag 952081 ggaggctaaa atggaaatca agctagaaca tgtatcaaaa aaatacggcc gccatacggc 952141 cgtcaatgat gtgtcaatca ccctatcatc cggacggatt tatggcctga ttggaccgaa 952201 cggcagcggc aagtcaacga ccctgaaaat gatggctggc cttctgtttc cgacttcagg 952261 atttgtaaaa gttgatgaag agcaggttac gagagaaatg gtgcgtcaaa cggcttatct 952321 tactgagctt gatatgtttt atccgcattt cactgttaaa gatatggtga atttttatca 952381 gtcgcagttt cctgattttc atacagaaca ggtttataag ctattgaatg agatgcagct 952441 gaatccggaa aaaaagatca aaaagctatc aaaaggaaat cggggcaggc tgaaaatcgt 952501 tcttgcttta gcgagacggg cagacgtcat cttgcttgat gaaccttttt ccgggcttga 952561 tccgatggtc agggattcca tcgtaaacag ccttgtgtcg tacattgatt ttgagcagca 952621 gattgtcgtg atcgcgacac atgaaattga tgaaattgag actttgttag atgaagtaat 952681 catcctcgcc aatggagaaa aagttgcgca gcgtgaagta gaagatattc gtgaacagga 952741 aggcatgtct gttttgcaat ggtttaaatc aaaaatggaa gtttgctaga aagaggagga 952801 atatgatgaa aacagtgttg gaattgaaaa acgtgactaa aaacatcaga ggccgaacga 952861 tcattgatga tctcagtttt acgattcgtg aaggcgaggt attcggtttt ttaggaccaa 952921 acggagcggg gaaaacgaca accatccgga tgatggtggg gttaatgaag ctgtcgaaag 952981 gtgatgtcct catttgcggc caatcaatta cgaaagaata tgccaaggcg attaagcata 953041 tcggagcgat cgttgagaat cccgagctgt ataaattttt gagcggatat aaaaatctcc 953101 agcaattcgc aaggatggtc aagggtgtca cgaaggaaaa aattgatgaa gttgttgaac 953161 tggtcggttt aacagacaga atccacgaca aggtgaaaac atattctctg gggatgagac 953221 agcgtcttgg cttggcacaa tgccttctgc acgatccgaa agtgctgatt ttggatgaac 953281 cgacaaacgg ccttgatccg gcggggatca gagaaatcag agatcattta aagaagctga 953341 cccgagaaag aggaatggct gtcatcgttt caagccacct gctgtcagaa atggaactga 953401 tgtgtgatcg aattgcgatt ctgcaaaaag gaaagctgat cgatattcaa aatgtaaaag 953461 atgaaaacat tgatgagaat gatacatatt tcttccaggt tgagcagccg agtgaagccg 953521 ctactgtttt aaatcagtac gatttgctga gtaagacaaa tggtgtagaa atcaaactgg 953581 ctaaagagga agtccctgcg gttattgaat tgctggtgat gcagcaaatc cgtatttatg 953641 aggtcaaggt cataacaaaa tcattagagg accgtttctt agaaatgaca ggtgaaacaa 953701 aagaggaggt tcagcatgct taatttgatt tataatgagt ggctcaaaat tttcagccgt 953761 gccggaacat gggtgatgat cggaattctg gggctgacaa tggttggatt tgcatttttg 953821 gcgaatcatt tttctgccgg tgaatcaaat tcccattgga aacaagagct tcaagcacaa 953881 aacgccgaat taaagaaaga aatcaaagaa gatccttcac tgaaagatgg gtataaagaa 953941 acaatcacac tcaatgacta tcgcatcgag cataatatcc ctagtgacac gggctatacg 954001 gtatggtctt atgtaacgga ttcagcaaac tttaccatcc ttaccggtct gtttactatt 954061 atcatcgcgg ccggaattgt cgcgaacgaa tttaattggg gaacgattaa gctattaatg 954121 attcggccgc tcagtcgttt tcaaattttg atgtccaaat atattacagt tctcctgttt 954181 gggctcctgt tgctgttgat tttatttatc ggttctactt tattagggtt gatcttcttc 954241 ggaacgggtg gtgaaaccgc cgcgaatatt catttaatct ataaggatgg ccatgtcatt 954301 gagcaaaaca tgatggggca tttggctaca acgtatcttt ctgaatccgt ctcggcttta 954361 atggtggcga cgatggcgtt tatgctgtct gcggtattca gaaacagctc tcttgcggtt 954421 ggtttttcca tcttcttgtt ggttgccggt acgactgcaa ctgcatttat tgcagcgaaa 954481 tttgactggg caaagtatat attgtttgct aatgtcgact tgactcagta tgtggatggc 954541 acaccgttaa taaaagggat gactatgacg ttttctctcg tcatgctggc gatctacttt 954601 atcatcttcc tgttgcttgc tttcggaatc ttcatgaagc gggatattgc aaactaataa 954661 aaaaagctgt tttgcttatg caaaacagct tttttgtcaa aataaaaact gcaggtttgc 954721 acctgcagtt tttcatatca atttatgctt acgcttcttt agtaacgtta gcagcttgtg 954781 gtccgcggtt tccttcaacg atttcaaaag aaacagcttg gccttcttct aaagttttga 954841 agccttcgcc ttgaatagca gagaaatgaa cgaatacatc gtcttgacct tctacttcga 954901 tgaatccgaa acctttttca gagttgaacc attttacttt accttctaac atgaaatttc 954961 ctcctaaagc gatcataacg cttaaattca ctattcttgc tcttaacaaa ctttcaagac 955021 gaaaactctt acaaaacttt cttcttaaag atagttcgaa caaaaataat tacctttact 955081 ctaccagtaa tcttcagaaa aaacaactgc ttattgaaat ttttttcgga aaataccata 955141 tttatttttc aatttgatat ttatttacgg aaattcatct gttttctcga tatgtgatca 955201 tacgtttgcc ttagtattcc ttcattttgg gaagataagt aataggaatt gacaacctta 955261 ttggatatga gtaaggtaaa agttaatcaa tattacaaat gacaacgttt atcaactaag 955321 agagcgtatg atttttatgt ctgatattgc ttgcatgctc taatacatag ataggagtat 955381 ggtcacaatg aaaaagtggc ttatatgcag tttcgtcctt gttcttctcg tttcatttac 955441 tgcatgttca ccgtctgcag aacatgaatc gataaaaatc gggattgctg agtctgacgg 955501 ggcaatatgg aactatattg ctcaaaaggc tgaagaggca gggctggata ttcagctgat 955561 ccctttttct gattatgcgg agtctgatat cgcacttgct aacaaagaaa ttgatgccaa 955621 cgcctttcaa accatttcat attttcagtc gttcactgaa aaatacaaac ttaatttggc 955681 accgctcggg acgacataca taacgcccat gggcatttat tcaaaacgat atgaacgaat 955741 ccgagatata tcgcggggag ctgtcgtttc tgttccggat aaagcgttcg attttggcag 955801 ggcgcttacg gtgctccagg aagcgggttt gctaacgctg aaaaacggat ttaacggaac 955861 aggttcagtt gatatgatta aagataatcc gagacacctg aaattaaaag ctgtccggca 955921 acaggatgca gtgagcggtg ccgacgtgtt tgtcatgaaa ccatcagaag caaaaaaagc 955981 gggcttgaac ccgaaaaagc atacgctaaa gagcggcgga ctcatgtctg aggaagagat 956041 gaatttgatt gttgtcagag cggaggatca agatcgggaa gcgctgcaaa ccattcttga 956101 gctttatcaa gctgatgata cagcggcatt tatagaaaaa gaatatcagg gagatcttgt 956161 cccggctttt ctgcctttga aacgtctttc agattggaag aatgaattcg aacattgaat 956221 tcattctttt ttttctgaaa aacacactct gttccgtccc gtttctttcg ctttgtaaag 956281 catttgatcg gcaagaatgg gcaaggatcc tggctgttcc gtattattgg ggtaatgagc 956341 ggcccctagt gatatcgtaa ctgaaagctc gtcgccgttt gttaatacaa tcggtgcatc 956401 acttacagtg ctcctgatcc gttcagcgat ccgggctgct ttatcaagag aacagttcgg 956461 caggagcacg gcaaattctt caccgccgat ccgagcggca ggatcagtat ttcggatggt 956521 ctgcttcaga cgtaacccta gctctttgag cacctgatct ccttcatgat ggccatattg 956581 gtcattgatg gtcttaaaat gatcgatatc catataaatc agtgcaaatt gaaaatgcgg 956641 ggtatcggcc gcctgctgat acagagcttt tgtggtttct tcaaattttc ttcggttata 956701 cacgcctgtt aaaaagtcaa agtgcgcctg aaacttatat tgtttaaaaa gaagatgtgc 956761 atttgtttca tgatcaataa tatataaact gagcatgccg cccgctattg atatgatcca 956821 aaaatacaaa tgaagttcgt atgaatgtaa atctataaga aaataaaagg aaaaggagat 956881 caagctattt gtgattatta aaagatagaa agcatgtttt agttgaactt tttttcttct 956941 agaaacaatg agtgacggaa tggcagcgat acaaatgata ataaccgagt atagtgcaga 957001 tgtgttcatc gtaatcagca agcggcctgc agtgatcatg gccagggccg ttgccgttga 957061 aacccagcct ccataaagag cggcaatcat aatagggata tttcgaagat caataattga 957121 atgctgatag gtaaatccaa aaaccatcag aataaccccg agcaaaccgc aggccagtcc 957181 tttaacagct tgaaaggata tgctgtcttt tttatgtact agcctttctt taaacaggtg 957241 ggtgaagaga taattaaatg tgattaaaat ggtcaaattt acaaacagtt ctttcagcaa 957301 atattatcac ccttatataa ggtactaaag atggaaggga aagaaaagaa caaaaaaggc 957361 attatataag gtttttttac ttgaattgat aagttaaaat aattcgcact tgacccatcg 957421 gaattagtgt aatatagtaa atgagaaaat ttgaagggag agtttacctg ctttggagac 957481 tttactggtt gtattacatg tatttatttt atttttactt atcttagggc tctttgttat 957541 gcagaaaaaa catgtttcct tctctaaacg tgtatttact gcgctggggc tggggattgt 957601 attcggattt gcgcttcagc tgatttacgg cccgacttca aatatagtca ttcaaacagc 957661 cgactggttt aatattgccg ggggcggata tgtcaaattg cttcagatgg ttgtcatgcc 957721 gctcgtcttt atttcgattc tcggcgcctt tacaaagctg aagctgacaa aaaatcttgg 957781 gaaaatcagc ggtttgatta tcgggatttt agtagcaaca acagcagttg ctgcagctgt 957841 cggtatcgcg tccgcgcttt catttgatct gcaggcgatt caggttgacc aaggaagtac 957901 agagctttca cggggacagg agcttcagca gaaatcagag gatatgacag cgaaaacgct 957961 gccgcagcag attgttgaac tgctgcctgg aaacccgttt ttagatttta cgggagctag 958021 accgacttca acgatcgctg tcgttatttt tgccgctttc cttggagtgg cattcctcgg 958081 cgtaaaacac aaacagccgg aacaggcaga aacatttaaa aaactggttg atgccgttta 958141 tgccattgtc atgcgtgttg tcacactcat tttgagactg acgccttatg gggtgctggc 958201 catcatgaca aaaacaattg caacgagtga tcttgacagc attctaaaac tgggcatgtt 958261 cgtgattgca tcatatgccg cgttaatcac tatgtttatc attcatttgc tgctgctgac 958321 gttcagcggc ttgaatccgg tgatttattt gaaaaaagcg gtgcctgtac ttgtatttgc 958381 atttacgtca aggtctagcg caggtgcttt accgctgaat attaaaacac agagaagcat 958441 gggtgtaccg gagggaatcg caaactttgc cggttcgttc ggtctttcga tcggccaaaa 958501 tggatgtgcc ggcatttatc ctgcgatgct ggcgatgatg attgctccga ctgtcggcca 958561 aaatccattt gacccggtgt ttattatcac tgttatcgca gtcgttgcca tcagctcctt 958621 cggggttgcc ggagtcggcg gcggagcgac attcgcggcg cttcttgttt tatcatcatt 958681 aaacatgcct gtcgcgctcg ccggtttgtt aatctcaatt gaaccgttaa tcgacatggg 958741 gcgtactgct ttgaatgtca gcggaagcat gacatccggt cttattacaa gtaaggtcac 958801 aaaagaaatt gatcaagggg catttcatga tcaatccaga gtgattgaag ctgaagaagc 958861 gtaacatatg aaaacgtgta atccaagagg attacacgtt tttttaacgg ccaggctcta 958921 agtcctccag catttccatc atcgtgttgt cgtccatgac attcattgcg ttttgttcaa 958981 aatgaatggg ttcagcataa tgcggctgtc tttttttcgc ggctgtctca gtttgcctag 959041 tttgagactg tgtatgctga tgctgtggtt gctgctgtcc agcgtgctgg tgctgacggc 959101 cattttgccg ctggctttga tgctgcgaac ggtcctggtt atcaccgctg cttccgctgc 959161 ttccgctaaa tgcttgtttg accatgtttc ctacattaga agcatcaaac gtgttatttt 959221 ctgaatttcg tctgttcatt tgtcctgtga taaacccgct gattctttgg cggatctgag 959281 gtgataatgc agtaataagc atagttgatc ctatgatcaa tgctgcgggg ctgattcctc 959341 ttcgctggtt gaacaacatg atccctcctt tgcagtgtat tcatattttc cccctcgtta 959401 gacaaattaa ccgttatatt tcccgggaaa gcatttcctc cagatttgca tgcataatta 959461 aagccagtta gaaaaaccta taagtaaagt gataaaggag gaattcacat gtttggaaaa 959521 aaacaagtcc ttgcgtctgt gcttcttatc cctttgctta tgactggctg cggtgtagcc 959581 gaccaaggtg agggcagacg tgataataat gatgtaagaa acgtaaatta tcgaaatccg 959641 gccaatgacg atatgcggaa tgtaaacaat cgggataacg ttgacaacaa tgttaatgat 959701 aatgtcaata acaatcgtgt aaatgacgat aataacaacg accgaaaact tgaggttgct 959761 gatgaagcag ctgataaagt aacagaccta aaagaagtaa agcatgccga tatcattgtg 959821 gctggaaatc aagcctacgt tgcagtcgtt ttaaccaatg gaaataaagg tgcagtagaa 959881 aacaatctga agaaaaaaat agccaaaaag gtaagatcta ctgacaaaaa cattgataat 959941 gtttacgttt cagctaaccc tgattttgta gagcgtatgc aaggatatgg aaagcgtatt 960001 caaaatggtg acccaatcgc cggattattt gatgaattta cacaaactgt acagcgtgta 960061 ttccctaacg ctgaataaat gaaagaagcc gcacaatttg tgcggctttt tctttgcgtt 960121 aatgacacac tgcgaactca ggctgcatag agtaaaaata aaaaggtaca agacggaccg 960181 gctcagggag ggagacgttt gcgggatggc ataggaaagc gtgcggcatc cgctctattc 960241 ctgtgcggag tccttgtgat gctggctgta agctcagcca tcgtatcaag cgcgatgtat 960301 atcctgtctt ttccaggtca ggcatctgga ataacaaaag aacaagtgac gaagcacatg 960361 aagaaagagt cattcaaaca ggccgatatt tattacactt ctaaggaaaa gtccttactg 960421 ccattgacga aagaaacgct tgaatatgcg gtcagtatta atcagattat gattggatat 960481 tcgaatcaaa agcctattga cattattttt tttcctaatg aaaaacagat ggaggcttac 960541 tccggtttat tggatgtagt tggtttttat tctgaacggg agcagctgat cggattgttg 960601 cctgaagaga aaaagaaact gttagaaggg gacgaggtag cggtttattt gtaccagaga 960661 ttgttgattc atgaatactc gcaccatgcg tttcaccaga aattgaagga gcttgagacg 960721 gatcccgatg agtttccgtt atggtttcat gaagggttaa gcgagtggat tgcgaactat 960781 gaattgctca tagatccgat cacgttttct gtcgtgccct ttgaccgttt gcagactgat 960841 cgagactggc aggaagctag agccgaatat gacactgatg tctatttgca aagcttttat 960901 atgatcgatg agctgacgga caaatacggg aaagacatta tttcagaaat gattaaggaa 960961 acggcaaaaa aaggggactt tgaaaaaggg tttaaatcag caacaaagga aagtcttgat 961021 caatttgaaa aagattttaa gaaaaaattt gaaaaaaaca gtgcggcatt ggatagtatc 961081 tatccaatgc ctttgttatt agtgaagtcc ttgctgaccc attccgcctt gtgtcggagg 961141 catttgtcct tgggcagggg cgaatgaatt tcgcagctgt tccatatcct gcgcatcaag 961201 ctgaggaacc tggtaatagc cgtgtttgtt ttggtatagg aaaatttcaa atgccatttc 961261 aacatactcc tgaatttgcg cagacagtac gcgtcttacg gccggatttg tcatttccag 961321 agaagccatc gtcagcatag aagcttgtgc tttaatcgcg caaagcattt gtcggctgat 961381 gatgctgtca tcaatatcat tcatggattg aacaggtttt ttaggctgtg acggctgcat 961441 gccgtaaaca gtctggttgt cttccttcat catataagtt gctgtttttt gtgaaggttc 961501 gcttcctgtt ttgaagcatt ctgcagttat attgtattga gatgtgatga attgatgttg 961561 acgatcaagg atgtttagta attcttgatc cttacagaat tgtctcagca tcataaactg 961621 atcaagcaca gtaagtgttc cggaaagcac ctcatgcata tcaaacattt catgtccgcc 961681 gtggttttta tgcggtttgc caggaatacc tttgttcatt tgggattgct gctgctgatt 961741 gaactgatcc aaaccgaatt cctccttttt tttcagatca gctgtatttt gtgtcagtct 961801 gccgtgtatt atgcagaagc ctgaaaggaa ttatatgctg tctgtcgaaa tgataagcag 961861 acaaaatcgt tgtcattatg tgtataaggg aggaaatatg atgaggcgta ttctgcatat 961921 tgtgttgatc acggcattaa tgttcttaaa tgtaatgtac acgttcgaag ctgtaaaggc 961981 agctgaaccg caacagccta tatcgattga gaaggcaata cagcaaaaag aaggacaggc 962041 acttgtcgaa ggatatgcag tcggccaggc tgtttccccg cagcattata aactgacaag 962101 ccctttttca aatgattata atgttgcgct ggcagaccgt aaaaacaaaa catcgcccga 962161 acacatcctt cctgtgcaaa tcccctccgc cttcagaagc caatttgggc tgcaaaccaa 962221 tccgcttctt cttgggaaaa agataacggt tcaaggaaag cttgaaaatt actttaacac 962281 gacaggactt aaaaacgttc agtcgatgaa cgtaaccgat gacacaaaaa ctccgccggc 962341 tgaacagcaa gtgaccataa atgaagcacg gggaaggctg aatgaagaag taacgataaa 962401 agggatcatt acagctgatc aaaacgcaat cggaggcggg aagctgtcga cctttttgca 962461 agatgaaacc ggaggcatta acatttattc gccatcccct gaacaatttc ccgaattaaa 962521 agagggtatg gatgtcacgg tgacagggaa aatcacgtct taccaggggc tgaaagaaat 962581 cgttccaaac tcatcaggca tcaaaatcaa ccagtcaaat caatccctcc ccgcccccaa 962641 acacttaaca atcaatgaac ttattaacgg cagcctaggt gatcagtatg aaggacgcct 962701 tgtgaaacta accgcttttg tttcctcaat tccaagttct cctgccggcg gcggttacaa 962761 tgtaacaatg attgatgacg accatcatgc aatgacgctc cgggttatga atgaaacagg 962821 ggtgataaac gagcttgatg agggcaaatg gtatgaattt accggtgtgt taagcagata 962881 ccaaaccttt cagctgcttc cgcgaaaatc ggctgacctg aagctgcttg aagagcagcc 962941 cgcacctccg tctgcagagg gagaatatga agggattgtt gaccgggtag ttgacggcga 963001 taccattcat cttaaatctc cggtgcttgg aacgacaaaa atccggtttg taaatgtaga 963061 tgcacccgaa acatatcaca caccaaaaaa tgacgcagat gaaaatcaat taagatttgg 963121 caaaaaagca tctgactatc taaaaacggt tctgtccccg ggtgataaaa ttactgtcaa 963181 ggtcgggagt gaagccaagg acagctatgg cagattgctc ggacaagtca taaccgaatc 963241 aggttcaaac gtgaacttag agcttgtaaa aaacggctat gctccgacgt attttatttg 963301 gccggttgac aatgaagagg attatcagca atttcaggcc gcagtagccg ctgcaaaaaa 963361 agatcaaaaa ggaatttgga atgaaaacga tcccctcatg gaaatgccgt ttgaattcag 963421 agccagagag caagggaaag gcctgacaag atatgtgggg gactcgtcga ataaaacata 963481 tgtgcagcca gctgactgga agaagatagc tgtggaaaac agaattttct tcgcctcagc 963541 aagtgaagcg gagagcgcgg gatataaaaa aaggcaaacg gcacctcaag aacatgtgcc 963601 gcttagaatt ctcagcatga atgatttgca tggcaaaatc gatcagcaat atgagcttga 963661 tcttgatgga aatggaactg tagacggcac gtttggacgc atggattatg ccgccgcata 963721 tttaaaagaa aaaaaggctg aaaagaaaaa ctcgctgatt gtgcacgcgg gagatatgat 963781 cggcggaagc tctccagttt cctctcttct tcaggatgaa ccgactgtag aactgatgga 963841 ggacatcgga tttgatgtcg gaaccgtggg aaaccacgaa tttgatgaag gcacggatga 963901 acttctgagg atcttaaatg gcggtgatca tccgaaaggc acaagcggat atgatggaca 963961 gaactttccc cttgtatgtg ccaattgtaa aatgaaatca actggagagc cctttttgcc 964021 ggcttacgac atcattaatg tggagggcgt acccgttgct tttatcggag ttgtcacaca 964081 gtcggcagct ggcatggtta tgcctgaagg aataaaaaat atcgagttta cagatgaagc 964141 aacagcggtg aataaggcgg ccgaagagct caagaaaaaa ggcgtgaagg ccatcgcggt 964201 tctcgcacat atgtcagctg aacaaaacgg caacgccatt accggtgagt ctgctgatct 964261 tgcaaacaaa acagattctg aaattgacgt gatttttgcc gcgcataatc atcaggttgt 964321 taacggtgaa gtgaatggaa aactgattgt tcaagcgttt gaatatggaa aagcgatagg 964381 tgtcgttgat gtagagatcg ataaaacgac aaaagacatt gtcaaaaagt ccgcggaaat 964441 cgtatatgtt gatcaaagta aaatcgaacc ggatgtcagc gcgtcagcca ttttaaagaa 964501 atacgaaaca attgcggaac cgattatcag cgaggtagtc ggcgaagccg ctgttgatat 964561 ggaagggggg tattcaaatg acggcgatac acctcttgga aacctgattg cggatggtat 964621 gagagctgcc atgaaaacgg attttgccct tatgaatggc ggcggcatac gtgaagcgct 964681 gaagaagggt ccaattacgt ggggagatct ttacaatatt cagccgtttg gaaatgtgtt 964741 aacgaagctt gagattaaag gaaaagattt aagagagatt atcaatgcgc aaatctcgcc 964801 ggtttttggg cctgactaca gcatcagcgg gtttacgtat acgtgggata aagaaaccgg 964861 aaaagcagtt gatatgaaaa tggcagatgg caccgagatc cagcccgatg ccacatatac 964921 attgaccgtc aacaacttta tggcgacggc gacaggagcc aaatatcagc caatcggact 964981 gctgggaaaa aatccggtga cagggcctga ggatttggaa gcgacagttg agtacgtgaa 965041 gagttttgat gagccaattg cgtatacaaa agagggaaga attaagcttg ctgaagccag 965101 tgatattgaa gaccctgtaa cagaagaccc gataacggaa gagcctggag atgatccggg 965161 gacggaggat ccgattaaag aggatccaag gccaggtgaa gatttgcctg atataaaaga 965221 aactccggga acagcaccgg ttcatcagct tccgccttca gccatttcga gattcaatga 965281 aataccaatc aacaacacaa aaaccgctga tactgctaat agcatcagca cattgccgtt 965341 acaaaccgag actgcggaaa gcgggtctga tcatcagctt ccggatacgt cagcgggcta 965401 ctataacttt atggtaatcg gtgcggcggt gacattgtca ggaacttatc tatatgtcag 965461 aagaaaaagg agcgcctcca gaacgtgaaa aaagttattc cactattcat cattgctgcc 965521 ggcctagtga tcgcaggcta tggaggcttt aaattgatcg atacgaatac gaaaacggaa 965581 cagacattaa aagaagcaaa gctggcggct aaaaagccgc aggaagcttc ggggacgaaa 965641 aatagcacag atcaagcaaa gaacaaagca tcatttaagc ctgagaccgg ccaagcgagc 965701 ggcattttag aaataccgaa aatcaatgca gagcttccga tcgtggaggg caccgatgct 965761 gatgatttag aaaaaggtgt cgggcattac aaggacagct attatcctga tgaaaacgga 965821 caaattgtgc tgtcagggca tcgggatacc gtgtttcgcc ggacgggaga gctggaaaag 965881 ggggatcagc tccgtcttct cctgtcatat ggagaattca catatgaaat tgtaaaaaca 965941 aaaattgtcg ataaggatga cacatctatt atcacgctcc agcatgaaaa ggaagagctg 966001 attctgacga cctgctatcc gttttcatac gtcggaaatg ccccgaagcg ctatattata 966061 tatggaaaac gagtgactta aaaagccgag gcagtgcctg cggcttttct tcatgaaaaa 966121 tatgtgcggc aaaggttttt catatcagca gggaaagggg cttcagcaac tatgagctcg 966181 tctgttatcg ggtgaaccgc ttgtacttta ttggcgtgca gtgcctgcct gtttagcagc 966241 ttgctcccgc ctccgtaaag cgagtctcct gtcaacggat ggccgaggct cgccagatga 966301 acacggattt ggtgtgttct gcctgtttcc agctctaatt caacgagcga cagccgttct 966361 ttcgcattgc tggccattac cttgaaatga gtgacggctg tttgcccgcc tggtgaaacc 966421 cggcgtcttg tcgggtgtga gcggtctctg ccgatcggtg aattaattgt cccttttttc 966481 gtccgtagct taccttcagc gatagcggta tacgtacgct tcagcgtctt tttctctaac 966541 tgctggtcta agatggcgtg tgccaaacga tgcttggcaa aaacgatagc gccagatgta 966601 tcctgatcaa gacgatggac gtggcgcacc ttacatgttt cgccatttat ctgataatga 966661 tacgcgatca aattagccag tgtgccggtt tgcccatcct cattcggatg cgtcgcgatg 966721 ccagcgggtt tattgatgat gagcatatga ttgtcctcaa ataaaatatc aagctcgcca 966781 tactccggaa tgaccgaaga tgcttcactt tcctgaagat caatgaacac gcggtctccc 966841 ttttttacaa tcatattgtt taagacggat tcgtgattga cctttatctg ttgatgggac 966901 atccagtctt gtatcactgg tttagaagct ttgagcgctg ttttgagtac ggaaaacagc 966961 cattggccgt cctgtttttc attgatgagg atctcaagcc ctctgccttt ttggttcatg 967021 ttaaatggct ccttttcgaa gcggaaggct gctgtttctc ataggaaaca cttaccttag 967081 ctttcgcgtt tttttctgtg ctattcttga gtaagactta ggatattcga tggcaagaaa 967141 ggtgattgac gtgagaattg tgaacgcagc aactgcagaa caggagagct ttatcaagga 967201 gctgtctatg gagctgatcc atgatgtatt tcctctttat ttctccgaac tggacattca 967261 gcgctttaaa aagaaaggcg ttctgtcttt aaataaccat tattaccaag gaacattaaa 967321 agaagcattt caaattatgg cttgtctgca aatgatacat attatcctga ccaagccttc 967381 gccgcactct gatttgagtg atcaggcgat ttttgaaaaa aacagcaaga tgctgaatga 967441 ttttgggatt tattttccgt ttgctttttc tgactttcaa aagaagacta acaaagcctt 967501 tttcggtcaa agaaggctga tataatcatg cggcaagggc ttttctattt ttagaaaagc 967561 tctttttgta tcagagaaat catatcataa aacctttcct ctaactccct ttttaaacgg 967621 ctcgtgtctg aacatactaa tgattgaaag gggtgctgac aatgagttca gttaaagata 967681 caatgacaac gcaggtggca accgtttctc cgaatcaaac gattcaggaa gcggcttctc 967741 taatgaaaca gcataacgtc ggggcgatcc ccgttgtaga gcaaggtgtt ttaaaaggaa 967801 tgctgactga ccgtgacatt gcattaagaa ctacagctca gggccgtgat ggccagacac 967861 ccgtttcaga agtgatgtca acagaactcg tatcaggaaa ccctaatatg agtctggaag 967921 acgcgtcgca gctgatggcc cagcaccaaa tccgccgcct tcctattgta gatcaaaaca 967981 atctagtcgg gatcgttgcg cttggagacc tggcagtcaa tcagatgtcg aacgagtctg 968041 cgggatcagc gctgacaaac atttctcacc aaaacattca ttaataagaa agagcttgca 968101 gtgtgcaggc tctttcttca cataaaacct tactttttga aagcagactt gtttcggggt 968161 atagtgagtg tatacatatg tctcaattcg tactaaagga gttgtaccca gtgattaaag 968221 cgttaatttt tgattttgac gggcttattc tagatacaga aacacacgaa tatgaggttc 968281 ttcaggaaat atttgaagag cacggctcag tgctgccgct atctgtctgg ggaaaggtca 968341 tcggaactgc tgcgggtttc cggccttttg aatatttaga agagcagatc gggaaaaagc 968401 tgaaccatga agagctcaca caattgagaa gagagcggtt tgccaaacgc atggaatcag 968461 aaaaagcgag acctggtgtc gaagcgtatt tgaatgcggc aaaggattta ggcttaaaaa 968521 taggccttgc ctccagctct gattataaat gggtgtccgg ccatttgaag caaatcggcc 968581 tgtttgatga ttttgaagtt attcaaacgg cggatgatgt ggaagaggtg aagccgaatc 968641 ctgaactcta tttattggcg gcaaagaacc tgggggtatc gccagcggaa tgtctcgcgt 968701 ttgaggattc tgtcaatggt tcgattgctg cgaaacgtgc aggcatgaag tgtgtcattg 968761 tcccgaataa agtaacgggt accttgatgt ttgaagacta tgatcacagg cttgaatcaa 968821 tggcggagat ggagctcgcc ctattgcttg atcatctgaa ctcacaaaac tagaaaggag 968881 cgagtaggtt gtctgagaaa ttagatttga cccggtttga aaagaaaatg gttatccgca 968941 atatcgaaga gaaagacatc gacaagatta tcgatcttca aaaggactgc tttccaggaa 969001 tggagccttg gaagcgggag catttaatca gccatttgga gcattttccg gaaggacagt 969061 tttgtgcaga attcgaaggt gaaattatcg gttcgtgctc aagtctcctg attaactttg 969121 atgaatatga tgaccgccat acgtggcagg acattacaga tgacggttat atcaccaacc 969181 ataatcctga cggcttgaat atgtacggaa ttgaagtcat ggtgcacccg aaatacagac 969241 gaatgaagat cggccaccgt ttgtacgagg cgagaaagga cttagccaga cgcttaaacc 969301 tgaaaagcat catcataggc ggacggattc caaactatca caaatatgca gaggaaatga 969361 cagcgagaga gtatgttgaa caggtgacac gccaccaaat ttacgatccg gttctttctt 969421 ttcagctgat gaacggcttt acccttatgc gaattaaccc gaactatctc ccggatgata 969481 cagcttcgat caagtatgcg acgctgatgg aatggaataa tgtcgattat ctaccgcagc 969541 agacaaaacg ctattataaa tcggcgttcc ctgttagaat ttgtgtgatc caatacgaaa 969601 tgaagaaaat ttattccttt gaggaatttg cgaatcaagt agaatactat gtcgatgttg 969661 cttccgacgc aagatctgat tttgcggtgt tcccggaaat tttcacaacc cagctgatgt 969721 ccttccttga ggaacggtca ccgagcttgg cggtgcagag aattaccgag tatacagaag 969781 attacatcag cctgtttact gacttggctg tgaagtataa cgtcaacatt atcggcggat 969841 ctcatttcgt cgaagaggaa ggcaagatct ataatatcgc ttacctgttc agacgggacg 969901 gaacgatcga gaagcaatac aaactccata ttacgccgaa tgaacgcaaa tggtggggga 969961 tcagcgcagg agaccaagtt cgcgtgtttg atacggactg cgggaaaatc gcgatccaga 970021 tctgttatga cattgaattt cctgagcttg cccggattgc ggctgataaa ggagccaaaa 970081 tcatctttac gccattttgt acagaagacc gtcaaggcta tctgcgtgtc agatactgtt 970141 cgcaggctag agcggttgaa aatcaaattt atacggttat ctctggaacg gtcggaaacc 970201 ttccgcaaac ggaaaacatg gatatccaat acgcccagtc aggcatcttt gccccgtctg 970261 attttgaatt cgcccgagac ggcattgtcg gcgaaacaaa cccgaatatt gaaatggtcg 970321 tcatcggcga tgttgacctg gaaattctca gaagacagcg ccaaaacggt acagtgcgcc 970381 agctaaaaga cagacgacgt gatatttatc atattcaata taaaaaataa ttcccaaaaa 970441 acccgcctga attggcgggt ttttttaaac aaaagcggaa ttgtttaggt gctttcttta 970501 aaataaaagt aaattgtata gtggatgtgc cttatggagt ttctgtattt tcgccatttc 970561 ctatatcata cagaaaacgg ctaggcttca cattgctatt gcaatggctg tccaagttgt 970621 ttcgagtgcg acctttatca gtacgatgct gagcattgtc actttgcctg ttttgctttg 970681 gaagctgcat cctctttctt cttgagaaag gggatgtttt attatttacg cggtttattg 970741 actctgaccc ggtctggctt tatattgaag gcagggaaat catcaccaag acatcacata 970801 aagagaaggt ctgtttcaat tgaattggca ttatagggaa cgctaatgaa atggagatga 970861 tggggatgga aaacattcag caaaatcagg gattaaagca aaaagatgag caatttgtgt 970921 ggcatgccat gaagggagcg catcaagcgg acagcctgat agcccagaag gccgaagggg 970981 cctgggtaac cgacacagac ggacgccgct atttggatgc gatgtccggt ttgtggtgcg 971041 tcaacattgg ttacggcaga aaggagcttg cggaggctgc ctatgagcaa ctaaaggagc 971101 tgccttacta cccgttaacg caaagtcacg cacccgcaat tcaactggcg gaaaagctga 971161 atgaatggct tggcggcgat tatgttattt ttttttccaa cagcggatcg gaagcaaacg 971221 aaactgcttt taaaattgcc cgccagtacc atctgcaaaa cggcgaccac agccgttata 971281 aattcatctc aagatatcgg gcataccacg gcaatacatt gggagcgctc tcagctaccg 971341 gacaggcgca gcggaaatat aaatacgagc ctttgagcca agggttcctg catgcagctc 971401 cgccagatat ataccggaat cctgatgatg cagacacgct tgaaagcgca aatgaaatcg 971461 accgcatcat gacatgggaa ttaagcgaaa cgattgccgg ggtcattatg gagcccatca 971521 ttacaggcgg aggcatccta atgccgccgg acggatatat gaagaaggtg gaggacattt 971581 gccggcgcca cggagccctt ttgatttgcg atgaagtgat ctgcgggttt ggacggacag 971641 gtgagccgtt cgggtttatg cactacggtg tgaagcctga tatcattacg atggcaaagg 971701 gaatcacaag cgcgtatctg ccattgtcag cgactgctgt gaaacgggac attttcgaag 971761 cgtatcaggg ggaagctcct tatgaccgtt tccgccacgt gaacacgttc ggcggaagcc 971821 cggctgcctg tgctttggcg ttgaaaaacc tgcaaattat ggaggacgaa cagctgattc 971881 agcgatcccg tgatcttgga gcaaagcttt taggtgagct tcaagctctg agagaacacc 971941 cggcagtcgg ggatgttaga ggaaaagggc tgctgatcgg aatcgaactc gtcaaagaca 972001 aattgactaa agagccggct gatgccgcca aagtaaacca agtggttgcg gcgtgcaaag 972061 aaaaagggct gatcatcggc aaaaacggcg atacagtcgc cggctacaac aatgtcatcc 972121 agcttgcgcc gccattttgc ctgacagaag aggacctttc ctttatcgtg aaaacggtga 972181 aagaaagctt tcaaacgata taatataaaa gtgaattatt aaaggagcac atgatgagtt 972241 ttcacaacca gccgatctta ccggctattc gcaatatgaa gcaatttgat gagtttttga 972301 acagttcatt ctcttacggt gttattcttg atattcatct cggccagctg aagggcgtga 972361 tcaaagaagc gcaaaagcac ggaaagaaca tgatggtgca cgtcgatctc attcaaggga 972421 ttaagcatga cgaatacggt gcggaattta tatgtcagga tatcaagccc gctgggatta 972481 tttccacaag atcgaatgtg attgccaaag cgaagcagaa gaaaatttat gccattcagc 972541 gcctgttttt gcttgataca agcgcgatgg agaaaagcat ggagtttatc ggcaagcata 972601 agcctgactt catcgaagtg cttcccggca tcgttccgtc actcattcag gaaataaaag 972661 agaaaacagg gattcccatc tttgccgggg gtttcatccg tacggaagag gatgtagagc 972721 aggcattgaa agcgggggct gtagctgtca caacatctaa taccaaattg tggaaaaaat 972781 atgaaaactt tttgacggaa agtgattgac accgctttca tgcactgata caattgcact 972841 aggttaatac attgtgatgg agaactcgga gaccacagca gctctttacg gcaaatgttt 972901 atgcacccgt aaagcggttt gttgtggttt ttttattctc ttcttctcta tcatgctttt 972961 taatcgtgac tttaggagga atgtgctatg acagcatttt ggggagaagt catcggtacg 973021 atgctgctta tcatttttgg tgcaggtgtt tgtgcaggtg tcaatttaaa gaaatcgctt 973081 tcattccagt ctggctggat tgttgttgta tttggatggg gattgggtgt tgccatggcg 973141 gcatacgcgg ttggcggcat cagcggtgcc catttgaatc cggcgctaac gatagcgctt 973201 gcatttgtag gagattttcc ttggaaagag gttccggttt atattgcggc gcaaatgatc 973261 ggagcgatca tcggtgcggt gattatttat ctgcattacc tcccgcactg gaagtcaacg 973321 gatgatcccg ctgccaagct gggtgttttc tcaacagggc ccagcattcc gcatacattt 973381 gcaaacgttt taagcgaagt gattgggaca tttgtccttg tacttggaat cttggccata 973441 ggtgcaaatc aatttacaga aggacttaat cctttaatcg tcggtttcct cattgtagca 973501 atcggtattt ctctgggagg caccaccggc tatgctatca atcctgcacg tgacttaggt 973561 ccgcggatcg cccacgcttt tcttccgatt ccggggaagg gctcatcaaa ctggaaatac 973621 gcatgggttc cggtagtcgg cccgatttta ggcggatcat tcggcggtgt attttacaac 973681 gctgcattta aagggcacat cacaagcagc ttctggattg taagcgttat attggttgtg 973741 gtattgttag gactctatgt ttatacgaaa tcacattctg ctaaaacatt atcaaattct 973801 aaatatattt aatcaaaggg gagacatctt atggaaacgt acattttatc cttagatcag 973861 gggacgacaa gttcaagagc gattctgttt aataaagaag gcaaaattgt ccactctgct 973921 caaaaggaat ttacacaata cttcccgcat cctggctggg ttgagcataa tgccaatgaa 973981 atttggggct ctgtcctcgc ggttatcgcc tcagtcatct ctgaatcagg aatcagcgct 974041 tctcaaattg ccggcatcgg catcacgaac cagcgcgaga cgacggttgt gtgggataaa 974101 gatacaggaa gtcctgtcta taatgcaatc gtttggcagt ccagacagac gtccggcatt 974161 tgtgaggaac ttcgtgaaaa aggatataat gataaattca gagaaaaaac agggctttta 974221 atcgatcctt acttctccgg cacgaaggtg aagtggattt tagacaatgt ggaaggcgca 974281 agagaaaaag cggaaaaagg cgagctgctg tttggaacga ttgatacgtg gctcatttgg 974341 aaaatgtcag gcggaaaagc gcatgtgacc gattactcca atgcctcaag aacactgatg 974401 tttaatattt acgatttaaa atgggacgat gaactgctcg acattctagg cgtaccgaaa 974461 tccatgctcc ctgaagtgaa gccgtcctct catgtgtatg cggagactgt tgattatcac 974521 ttcttcggaa aaaatatccc gattgctgga gcggcaggcg accagcagtc cgcattgttc 974581 ggccaggcat gctttgaaga aggcatgggg aaaaacactt acggcacagg atgtttcatg 974641 ctgatgaata ccggggaaaa agcaattaag tccgaacatg ggcttttgac aacaatcgct 974701 tggggcattg acggaaaagt gaactatgcg ttagaaggga gcatttttgt cgcaggctct 974761 gccatccagt ggcttagaga cggtttgaga atgttccagg attcatcgct aagcgaatct 974821 tatgcagaaa aagtggattc aactgacggc gtgtatgttg ttccagcatt tgtcggactg 974881 ggaacgcctt actgggacag cgatgtgcgc ggttcggttt tcggcctgac aagagggaca 974941 acaaaagagc actttatccg tgcgacactg gagtcattgg cttatcagac caaagatgtg 975001 cttgacgcaa tggaagcaga ttcaaacatt tcattaaaga cgctccgtgt agacggagga 975061 gctgtaaaaa acaatttcct aatgcagttc caaggagacc tgttgaatgt tcctgtggag 975121 cgcccggaaa ttaatgaaac gactgcactt ggcgcggctt atttggcggg tatcgctgtg 975181 ggattctgga aggaccgttc tgaaatcgcg aaccagtgga atctggataa acggtttgag 975241 cctgaattgg aagaagaaaa acgaaatgag ctgtataaag gctggcaaaa agccgtgaaa 975301 gcagctatgg cttttaaata aagtaatact atggtataat ggttacaagt taataagaac 975361 ggtcctgaga tgaggagaga ccacagcacc aaagtgtaag catgcacttt ggctgttgtg 975421 gtctcttttt ctatttaccg tgacaacaag gaggaaacgt aatgatgaat catcaatttt 975481 caagtcttga aagagatcgc atgctgacag acatgacgaa aaaaacatat gacctattta 975541 ttatcggagg aggaattaca ggagccggaa cagctcttga cgcggcatca aggggaatga 975601 aggtcgcact aagcgaaatg caggactttg cggcgggaac atcaagccga tcaacgaagc 975661 tggtacatgg cggcttgcgc tatttaaaac aatttgaagt gaaaatggtc gctgaggtag 975721 gaaaagagcg ggcgattgtg tatgaaaacg gcccgcatgt cactacaccg gaatggatgc 975781 tgcttccgtt tcataaaggc ggcacattcg gttcatttac aacatctatt gggttaaggg 975841 tttatgactt ccttgcaggt gtgaaaaagt cagaacgaag aagcatgctt tcagcaaaag 975901 aaacgctgca aaaagagcct ttggtgaaaa aagacggctt aaaaggcggc gggtactatg 975961 tggaataccg cactgacgat gcgagactga ccatcgaagt catgaaggaa gcggttaaat 976021 tcggggcaga gcctgtgaat tactccaaag tgaaggagct tctttacgaa aaaggcaaag 976081 ccgtcggcgt attaattgaa gatgtgctga caaagaaaga atataaagtg tatgcgaaaa 976141 aaattgtcaa tgctacaggc ccttgggtcg atcagctcag agaaaaagac cattcgaaaa 976201 acggaaagca tttgcagcat acaaaaggca ttcaccttgt atttgaccag tctgtctttc 976261 cgctgaaaca ggctgtatat ttcgatacac ctgatggccg gatggtattt gcgattcctc 976321 gtgaaggcaa aacatacgtg ggaacaacag acactgttta caaagaggcg ctggagcatc 976381 cgcggatgac aacggaggat cgtgattatg tcatcaaatc aatcaattac atgttcccgg 976441 aactgaatat cactgcgaat gacatcgaat ccagctgggc ggggctgcgt ccgctgattc 976501 atgaagaagg caaagatcct tctgaaattt cacggaaaga cgagatttgg acatctgact 976561 caggcctgat caccattgcc ggcggaaaac tgactggata cagaaaaatg gcggagcaca 976621 tcgttgatct tgtccgtgat cgcttaaaag aagagggcga aaaggatttt ggaccatgta 976681 aaacgaaaaa catgccaatc tctggcgggc acgtcggcgg ttcgaaaaat cttatgtcct 976741 tcgttaccgc gaaaacaaaa gaaggaattg cagccggttt atcagaaaaa gacgcaaaac 976801 agcttgcgat cagatacggc tctaacgtag atcgcgtctt tgaccgggta gaagcgctga 976861 aagatgaggc cgcgaaacgc aacattccgg ttcatattct tgctgaggca gaatacagta 976921 tagaagaaga gatgactgca acccctgctg acttctttgt ccgcagaacg ggacgtttat 976981 tttttgatat caattgggta agaacatata aagatgccgt tattgatttt atgagcgagc 977041 gattccaatg ggatgagcag gcgaaaaaca aacatacaga aaacctcaac aagcttttac 977101 acgatgcggt cgtaccgctt gagcaataaa tcataacggg ctgtctgcag cccgttattt 977161 ctttttacgt gccgaaaggg ggagatctca ggttatcaag tgacagaggc acccgcttca 977221 tataaaataa tggcataagc tgatacatag gaggacgaat atgacttgga gaaagagcta 977281 tgaacgctgg aaacagacag aacatttaga tctggaatta aaagagcgcc ttattgaatt 977341 agagggagat gaacaggccc ttgaggactg tttctataaa gaccttgaat tcggtaccgg 977401 cggaatgcgc ggggaaatcg gcgccgggac aaatcggatg aatatttaca ctgtgcgcaa 977461 agcatcggcc gggtttgcgg catacatctc gaagcaaggt gaggaagcga aaaaacgggg 977521 cgttgtcatt gcttatgatt cccgccataa gtctccggag ttcgcgatgg aagcggcaaa 977581 aacacttgcg acacaaggca tccaaacata cgtgtttgat gagcttcgcc cgacgccaga 977641 gctgtcattc gctgttagac agctgaacgc ttatggtgga attgtggtaa cggcaagcca 977701 taacccgcct gaatataacg gctacaaagt atacggggat gatggcggcc agctgcctcc 977761 aaaggaagcg gacatcgtca ttgagcaggt aaacgcgatt gaaaatgagc tgacgatcac 977821 agtggacgaa gaaaataagt taaaagaaaa aggcttaatc aaaatcatcg gtgaagatat 977881 tgataaagtt tatacagaaa aactgacgtc catttctgta catcctgaat tatcggaaga 977941 agtagatgta aaggttgttt tcacaccgct gcatggaact gcaaataaac cggtcagacg 978001 cggtcttgaa gcactcggct acaaaaatgt aacggttgtc aaagaacagg aactgccgga 978061 ttcaaacttc tccactgtta catcgccgaa cccggaagag catgcggcat tcgaatatgc 978121 cattaagctt ggggaggagc agaatgcaga tattctcatc gcgacagatc ctgatgctga 978181 ccgcctcggc atcgcggtga aaaacgatca aggcaaatat acagtgctga caggaaacca 978241 aaccggagcg ttgctgcttc attacctgct ttctgaaaag aaaaaacaag gcatcctgcc 978301 tgataacggt gttgttctca aaacgatcgt cacaagcgaa atcggccgtg ctgtagcttc 978361 ttcattcggc cttgatacga ttgatacgct gacaggcttt aagtttatcg gtgaaaagat 978421 taaggaatac gaagcatcag gccagtatac cttccaattc ggttatgaag agagctacgg 978481 ttatttaatc ggggattttg cccgcgataa ggacgccatt caggctgcgc ttttggcagt 978541 tgaagtttgc gcgttctata aaaaacaggg aatgtcattg tatgaggcgc tcatcaatct 978601 ctttaacgaa tatggttttt atcgtgaagg gctgaaatcc ctgacgctga aaggcaaaca 978661 aggagcagag caaattgaag cgattcttgc ttccttcaga caaaatccgc cgcagaaaat 978721 ggcgggcaaa caggttgtca cagcagaaga ttacgctgta agcaaacgga cgcttctgac 978781 tgaaagcaaa gaagaagcca tcgacttgcc aaaatcaaat gtattgaaat acttcctgga 978841 agacgggtct tggttctgtc tccgtccttc tggaactgag ccgaaggtta aattttattt 978901 cgccgtaaaa gggtcatctt tggaagacag tgaaaagcga cttgccgtcc tttctgaaga 978961 tgtaatgaag acggtggatg aaattgttga gtcaacagca aaataattca agtatgagct 979021 gggtcattgt aaatgatccg gctttttctt tttctcatcc aaaagtctga aagaaaatca 979081 tcctacaagt gaagcaatga aatacaaaaa actggtataa tcttaaatac aagatcaatg 979141 ccggagtgag aaacgtgagc aaaacgagga tggaaaaatt aaaaacgctg aaaacgattg 979201 cggaaacctt aaatcaaggg cacgatatca aagcaacact ggatgaggtt ttaaaagagt 979261 tgctgagtct gacaaacctt caatccggat ggatttttct gatcgaagaa gatgggtctt 979321 atacgttagc ggccgacgct tatctgcccc cggctttaag ccgcaaggaa aaagtgctga 979381 tgtgcgaagg ggagtgttac tgcctgacga aattcaataa cggagggctt agaaaagctg 979441 caaatatcat gaactgcaaa cgcatcgaat cagcagaaaa cctgcattgt tttgacacag 979501 aagggattac gcatcatgca actgtgcctt tagaagacgg ggacagaaga ttcggattgt 979561 taaatgtagc ggcggccgga aaaaccatgt ttgatgagga agagctgcat ttactcgagt 979621 ctgtcgcctt tcagatcgga acggcaatcc agcgtatgag gctttctgaa tatcaacaaa 979681 aaaatgctct tttaatggag cgtaaccgcc tcgctcagga gcttcacgat tcagtcaatc 979741 aaatgctgtt ttccgtcagt ttaactgcca aagctgcgaa gacactaaca aaagatgaaa 979801 atttacagca gatgattgat ttcatccaaa acctatcaca ggacgcgctc gcagaaatga 979861 aagcgttaat ttggcagctt cgccccggag gattggaaaa agggctggct gaagccatta 979921 aaagctatgg tgcgctcatt ggattgaaga tcatttttac acaaaaaggc tgtcctgttc 979981 tgactgatga gcaggagcat atgctatggc gtgtcgtaca ggaagcttta aataactgca 980041 aaaagcatgc cggaacggat acggcgtatg ttagtctgac tgcttctttg tgccatgcgg 980101 agctggatat catcgatcat ggggcaggat ttcgctatga agcgcatgcc ggtctgcctt 980161 cacttggcat aaaaggtatg aaagagcgag cggaaaaagc cggagctaag ttttggattg 980221 agtcagcgct tggaactgga acaaagctgt ccatcaggct tccgctaaaa agccgaaaag 980281 gaggggcggt atgaaaattg tcattgctga tgatcatcat gttgtcagaa agggtctgcg 980341 ttttttcttt gccacccagg atgatattga agtcgtcgga gaagctgcaa ctggattaga 980401 agccctccgt gtcatcgaag agacaaagcc ggatcttgtg ctaatggatt tgtctatgcc 980461 cgagatggac ggcattcaag ccattaaaaa agcaatacag caatttccgg atacgaatat 980521 cattgtgctg acgagctact ctgatcagga gcacgtcatc cccgcgcttc aggcaggcgc 980581 gaaggcgtat caattaaagg atacggagcc cgaggaattg gtgaaaacac gacaagtgca 980641 tggtggcgaa tacaagcttt ctacagctat tatgccccat gtgctgacac atatgaaaaa 980701 tcagcacgac ccggaaaaag aaaaatacta tcaattaact agaagggaaa aagacgttct 980761 gactgaaata gcgaacggga aaagcaataa agaaatcgca gcagccttgt ttatttcaga 980821 aaaaacagta aaaacccatg tatcgaatct tttagcaaaa cttgaagtgg ccgatcgcac 980881 gcaagcagcg cttttcgcag tgaaatataa cctgaatgga gagatctcaa aatgaacatg 980941 ttagtcataa atggcacgcc aagaaaacat ggcagaacaa gaattgcagc atcctatatt 981001 gcagctctgt atcacacgga tttgattgat ctaagcgagt ttgtattgcc cgtttttaac 981061 ggtgaagcgg aacaatctga actgttgaaa gtacaggagc ttaagcaacg cgttacgaaa 981121 gcggatgcga ttgtattatt atcgcctgaa tatcacagcg gcatgagcgg cgctttaaaa 981181 aatgccttgg attttctaag cagcgaacaa ttcaaatata agcccgttgc attattggca 981241 gtagcgggag gcggaaaagg cggcatcaat gcgctgaaca atatgagaac tgtgatgcgg 981301 ggtgtctacg ccaatgtcat tccgaagcag ctggtgcttg atccggtgca tattgatgtt 981361 gaaaatgcta cagtggctga aaacattaag gaaagcataa aagagcttgt cgaagaactc 981421 agcatgttcg caaaagcagg aaatcccggc gtctaaacgc cgggatttgt ttatgtgaga 981481 agggctattt gatcttcata agtcagctct gtggcatgat caatatatcg gagaagggaa 981541 tacagcatct tttctaaaac ggcgtaatcc tgttcaaaat gatacgcatg cagaaaatgc 981601 tcaattcgtt ttgataacaa atcgtcctct gtacgcacca ttaaaattaa taaattatcc 981661 cattgagaac gatgggtgta ataaagcgct ttatcgtaat cggcataatc catgaatcgc 981721 ttctcctttc ttgggtgaga agttcatgat tagtttatgc cgcatcctct gttattgacg 981781 gggcaaaact tgccgtctgc gtcagtaaag gggtagcaat atgagggaga cataaaatca 981841 aaatgcctga atgaagatat cgcttttggt aaacctatga gggaatatat tctgggtaca 981901 ggagactgaa aaaatgaaat ccctgccgta taccatcgca cttctttttt gcggattgat 981961 tatcgtgtca atggctgcaa aaggtcattc aacggacaca gacgagtccg ttcaaaagtg 982021 ggaacagctt gcctggagca aaattcagga tgaatataag ggcgcttcat tttctgatta 982081 tgcttatatg gggcgtacag aggtgaatga tcagcagact aaagatgtct ttcgggtgac 982141 agtcagacag aaagatgaca ctttttctgt tcgggccgaa gtctattttc atccggtgac 982201 aaatcatatg atcagcatca acgtctttag gctctaataa aaaactgtac agccgttaag 982261 gccgcacagt ttctgttttt agaaatatcg ttttgcaccg agatagcgct gtttccagta 982321 agagttgttc atattggaaa tgacaactcc ggaatcgttg gcatttatga attccccgtt 982381 gcctaggtaa attccgacgt gggaagggcc ggctttatat gttgaaaaga aaacgaaatc 982441 tccgacagca ggctggctaa ctgatttcat tgtgttccaa tatcccgctg ccgttaatct 982501 agatacggat gtgactttgt tcagtacata gtaaatgaat ccgctgcagt caaacccgga 982561 cggtgtcgtg cctccccagc gatacggaac cccaagctgc gctttagcgg ccgaaatcat 982621 tgtgttaatc ttcgcactcg ttgagctggt ggtgtttgaa gaaccggatg aagacgatga 982681 tgaagctttt ccggaaatga ccagcttttg gccaacctgc aagacatccg tttttaaatt 982741 gtttttctca cgaatctgct gagctgttac attaaatttt tgagcaatca cccataagga 982801 atcaccgctt ttcaccgtgt atgtagtcgt cgtgccggag cttgcatttg acgaagaaga 982861 cgacgatgat gaagagcctg aagatgcttt acctgtcagc ttcaatactt gtccaacgta 982921 aagcacatct gatttcagat tgttgatatt tcggatttgc tgtacagtca ggttatagtt 982981 gtttgcgatt ttccaaagtg aatcaccgct tttaacggta tatttagttg ttgctgaagt 983041 ttggttcgat ttggatgaat tgtctttaga agacgtatca gagccgcttg attttgtttt 983101 caacacctga ttcacgtaaa tggtgtctga ttttaagttg ttcaagacct tcaattcagc 983161 gatggacata ttgactttgt ttgcaatttt ccaaagtgaa tctccaagct gcaccttata 983221 tgttcccgta gaagatgaag aacttgaact cttattagaa ctgctttttg aactggagct 983281 tgaactctta ttagagttgc tttttttact ggaactagag cttgaagaaa cagtaccgga 983341 cacctttaat ttctgcccag cacgaattaa atcgctgctt agtccgttta attttttcag 983401 ttcctgcacc gtcattttaa actcatttgc gatcagccaa agtgaatctc cgcttttcac 983461 tgtgtaaaca gaacttccgc tcttcttggt tgttgagctt gaagtagatg aagaagtgct 983521 ggatttgctg cctggaatag taagcgtctg gccgatcgac agaacagtag tcgaaagatg 983581 attggcggat gtgagggccg ccacacttgt gttataggtt tgggccagtt tccataaaga 983641 atctccgctt ttgaccttaa tcgttgctgc ttcagctggt gtcactacta aagttgtgcc 983701 gacaatcgca gatgctgtca gccctgctgc taatttcttt ttcatcttag ctctcctttt 983761 tcccccaatg attttgcatt tgctgtttct tttttatatc ggcacatttg tctcatcgtt 983821 ttgccttttt ataaaaatag ccaaattatc ttaacaataa gggggaaaaa gggcataaaa 983881 aaagaaggaa tcttaatcta ttccttcatt tttaaaagct tcatgatatc ttctttgttt 983941 ttgacgaggt cgcgcagtgt gtatttgtct aaaactgcga ggtaggctaa aagcgcttca 984001 ttcagcacat gttttaagcc gcaaaccggg gaaataacac agagattctt gttcgcatca 984061 aaacattcaa caatattaaa atcgtcctcc gtttttctga caacctcacc gatgttgatg 984121 tcttcagggt ccatgcctaa tcgtatgccg ccgccccgtc cgcgtatcgt ttctacgtag 984181 ccgagctggc cgagcctgta tatgactttc atgagatgat tttttgaaat agaatacgtt 984241 tcggcaatct gttttatatt tgaaagttct ccgggacgct ctgcagccag aaaaatcaac 984301 actcttaatg aataatctgt ataattggtt aacttcataa taagacctca gaataagaca 984361 ttttctatat cttatcataa tcgattgaaa aatgaaaaaa aaggaattaa aaaacatgca 984421 cccagctggg tgcatgtttt ttgcttacat gtcattcggc ggattttggt ttttacggtt 984481 tttttcgatt tctgtgtttt gcattttgcg ttcaaatgta gacagataac gtgatgcaaa 984541 atccttaccg ccaaggccga aggataaacc aaaagcaagt gcgaagccgc taagaacgat 984601 gatgaacgcg gaattgacga ttgtcgcagc gacacccagc tgatccaggg ccataaagaa 984661 agcaagtgcg ataatcgtat atttagcaat aggcgctaaa gacttgaatt cctgaccttt 984721 tatcatgctt gcgagcactt ttctcaccaa ttctcctgcg taaaggccga gtccgagaat 984781 gaatactgcg acaaggacat tcggcagata cgcgatgatg ccggtggcaa tttctacgag 984841 gaagtgcagc cgaacaattt gaagcgcctc agctgtaaag agcagaatga caatgatttg 984901 cgcaatcata ccgacaactt gagacaagga cagctttgca ggcgttccgg cttccatgcc 984961 cattttccct aagacagaat caaagcctgc gcgatggagc agtccggaca ccatggattt 985021 cacccatttt cctgcccaga tacccgctaa tacaagcacg atggcaatca tgatgttcgg 985081 aagcatgttt aaaatcgtat tcagcataga gacagctggt tttgaaatgc cggcgacatc 985141 cagctgatca agcgctgaaa tgaccaccgg aatcataatg agcacataag cgattgttcc 985201 gatgactgct gaaaggcttg tgtcttttaa gtaaattgat aaacccatac gtgccgcgaa 985261 tctttcggtg ccgatgcttg caaggaaatt cgtaatgata tcacggacaa ggcgggcaac 985321 aagccatccg attaatacga taagcgccgc tgcaaataat ttcggcagaa aagcgagcac 985381 gctttccatc atatttgtaa aaggacctga aatgccgctg attttcaaag aagataagac 985441 ccctggcaga aaaacaagca gcacgagata aaagacaatt tgtgaagcgg tattgacagc 985501 ctggtgaata tcttttcctt cagacaccaa attccacttg cgcagtttgt cactcgtgtt 985561 cagcttcatc ccgatttttt tgacaaggaa gctcaaaaca gaagctgcag cccatcctaa 985621 cagcagaatg agtccggctt tcagcacgct tgggatcgca gctgcaatcg ccgaaagcat 985681 actgacaaac ggcgatgcca ctgttgtcag gtgcaaaatg ttaaagaata aaataaagac 985741 gatgatcagt gcgataaaat aaacgacctt gcttatgact ttttccgagg aatagcgtga 985801 aggctttttc ccagcaaaga gcttgtcgtc gatttttgtt ttgctgagtc ctttgtatac 985861 cgctttttca atgattttag caatagccca gccgattaat aagacgagta aagcaatgat 985921 tacgtttggc agcttactga gataagaaga aaacacgtct gctacattca attggtatcg 985981 ctcctttttc gtagtatggt gtgtgtttac ccacttatcc aataagcaaa cagatgaatg 986041 tgccggggga attttttctt gcccgagtga gactatcatc ttttgtctgg cgggctcata 986101 cattatagat aagtccaagt aggggggatt cggttgaacg cggaggagaa gaagggatta 986161 cagcgggcaa ttgaggaaat taccgaaatt gcaaaaggat tcggccttga tttctacccg 986221 atgagatatg aaatctgccc ggctgaaatt atttatacat ttggcgcgta cgggatgccg 986281 acaagattca gccactggag cttcggcaag cagtttcaca agatgaagct gcactatgat 986341 ctagggttaa gtaagatcta tgagctggtc attaactcag atccatgcta cgcttttttg 986401 ctggacagca actcactgat ccaaaataaa ttgattgtcg cacacgttct tgctcattgc 986461 gatttcttca aaaacaactg ccgtttccaa aacacgaagc gcgatatggt ggaaagcatg 986521 gcggcaacag ctgaacggat aaaacactat gaacaggttc acgggataaa agaagtcgaa 986581 tcttttttag atgcaatcct ttcgattcag gagcatatcg atccgtcgtt ggtccgacca 986641 aagctccaat ggagtgtgga tgatgaggaa gaggagattg aagaggcagc cacgccttac 986701 gatgatctat ggtctttaga tgaaaagaaa ccgaaaaaac aagtgaaaaa atcgaaaaaa 986761 ccgttcccgc cgcggcctga aaaagatatc ctgcttttta tcgaggagca ttcccgggag 986821 ctggagccat ggcagcgtga tatattaacg atgatgagag aggaaatgct ttatttctgg 986881 cctcagctgg aaaccaagat tatgaatgag ggctgggctt cctattggca ccagagaatt 986941 atacgtgagc ttgatttaac ctctgatgaa gcgatcgagt tcgccaagct gaatgcaggt 987001 gtcgttcagc cgtccaaaac aggcattaat ccttattatt tagggctgaa aatatttgaa 987061 gacattgaaa agaggtacaa caacccgacg gaggaaatga agaaaatggg cgtgcagcct 987121 gactccggcc gggagaaaat gtttgaggtc agggagattg aatccgatat ctctttcatc 987181 cgcaattatt taaccaaaga attagtcatg cgcgaggatc tttatttgtt tcaaaaacag 987241 ggccgagatt ataaaatcat cgataaacag tggaagtcgg tgcgcgacca gctcgtaagc 987301 atgcgggtaa atggcggttt tccatatttg acagtaaacg acggcgatta tatgaaaaat 987361 aacgaactct atattaagca ttggtatgag ggcatagagt tggatttgaa atatttggag 987421 aaagtgcttc cttatttatt ccagctttgg ggaagaagcg tgcacattga gtctgtgctt 987481 gaggataagg aagtcatgtt ttcgtacgac ggaaaaggtg ttcaccgcag atatttataa 987541 aaaagaggat gcagcgttct gcatcctttt tattttccag tttttaaaat cttaaatatg 987601 atgtttgcct ggtccgtatt gttaatcaat ccgcggaatt tttcttttcc ggggccgtac 987661 gcgtataccg gtacttcttc gccggtatga tcggtactcg tccatccgct gttggagcgg 987721 gtattaaaaa tcttgatgat ggctttggag gcccctttgc ttttgtcagc ctgtgcagct 987781 gcttcaacgc ttttgatttc ttcagatgtg actttcagat tggcatagcg ggcgagcaca 987841 tctttaaccg gcttgccttc actgattttt ttggccatga attcaggtgt tttcttagcg 987901 gagagaatcg gttctgcgtg ccaattcttt tccccgtttg cgccaatggt aaagccgccg 987961 gttgtatggt cagcagttgc aatcacaagt gtatgtttgt cttttttcgc aaattcaatc 988021 gcggctttat aggcctgttc aaaatcttta acctcgctca tggctcctac tgtatcattg 988081 tcatgggccg cccagtcaat ctggctccct tcgaccatca agaaaaatcc ttttttattt 988141 tggttcaggc gatcaattgc tgaaaccgtc atgtctttga gagacggtgt tttactgtca 988201 cggtcgagcg ctttagcaag ccctccatct gcgaaaagcc cgagcacctg ctgatcttta 988261 ttttttttca atgcttgttt agttgtcaca tagctgtagc cggcttgttt gaattccttt 988321 gtcaagtttc tgtccttgcg gttaaaataa gattttccgc cgccgagcag cacgtctatt 988381 ttatgtttgc cttttatctt gtcatccata tagctgttgg cgatttggtc catgtttttc 988441 cgtgattcat tgtgggcgcc atatgcggct ggagtggcgt ggttaatttc agacgtggcg 988501 acaagccctg ttgacttgcc ttgctgtttg gcctcttcaa gtacagattt cacttttttt 988561 ccgtttttat cgacgccaat tgcattgtta tatgtcttaa cgcctgtcgc taatgctgtt 988621 ccggctgctg ctgaatctgt aatattatag tcagggtcat ccggatgcgt catcatcatg 988681 cctgtcaggt tccggtcaaa ttctgttaac ttcgggttat tcggtgtgtc accgttattt 988741 ttcatggaac ggtaggctct tatgtaaggc gtccccatgc cgtcgcctat catcacaatg 988801 acatttctga tctcagcttt gtcttgtttt ttggcgctgg ccttttctgt ttgctgaagc 988861 tcagctccgg caaagattcc agctgtaagg acagaaacag cggcgattgg cagaagtttt 988921 gatttcatat tttgaaacaa actcattttt ttcatgcctc ctttaatgta ttccgtttat 988981 catgttaggg aaactttgtt aaatgcggct gttgatcatg taaacaataa gtaaagcctt 989041 gtaaggaaat gaaaaaacgc ttttcgttat cttgccttat ttgatgtaaa gcattcattt 989101 ttcagaaaaa tctttacctc tctgtctttg catgatatgt ttgtttaaat aaaaaaactg 989161 cggataacca cagctctcct cgaatatact ttatcactca tttttccgat atatgagccg 989221 accccgaaag tttttcattt atttccttta tgttgaaaaa catcccataa aacatgacaa 989281 aagcactcgt tttttgtcac ctttgcaatg aaaatgaaat atttaatacc cttaaaaact 989341 tttttttaga acgaataatt aagaaatttg tcacatgaag tcaagactat ttctgatggg 989401 aatctatcct tataatagaa atcaataaga ttaatttaaa aaaagagata catatatata 989461 gagttaacat ttggggagga aaatatgaaa aagcaaatca ttacagctac gacagcagtt 989521 gttttaggat cgacgttatt tgcaggagcg gcatctgcac aaagcattaa ggtgaaaaaa 989581 ggcgacacgt tatgggatct ttcaagaaaa tacgacacaa cgatcagtaa aattaaatca 989641 gagaaccacc ttcgttcaga cattatttat gtgggacaaa ctttatcgat taacggcaaa 989701 tctacaagtt caaaaagcag cagttcttct tcctcttctt ctacatacaa agtaaagagc 989761 ggggacagcc tttggaaaat ttcaaaaaaa tacggcatga caatcaatga actgaagaag 989821 ctgaatggct taaaatcaga tttgcttcgt gttggacaag tcctgaaact gaaaggttca 989881 actagttcaa gcagctccag ctcatcaaaa gtgtcatcgt cttcaacttc tacttataaa 989941 gtgaagagcg gagacagcct ttctaaaatt gcgagcaaat acggcactac ggttagcaaa 990001 ttaaaaagct taaacggctt aaaatcagat gtaatctatg tcaaccaagt attgaaggtg 990061 aaaggaacaa gcacaagcag ctcaaaacct gcttcatctt catcgtcttc aagcagcaaa 990121 acgtcatcta catcacttaa tgtgagcaag ctggtttctg atgcaaaagc gttagtcgga 990181 acgccatata aatggggcgg aacgacaact tcaggctttg actgcagcgg attcatttgg 990241 tacgtactga ataaacaaac aagtgtgggc agaacaagca ctgcaggata ctggagttct 990301 atgaagagca ttgccagccc gtctgttggt gatttcgtct tcttcacaac atataaatcc 990361 ggcccttctc acatggggat ttacattgga aacaacagtt tcattcatgc aggatctgac 990421 ggcgtacaaa tcagcagcct gaacaacagc tactggaagc ctcgttacct cggtgcgaaa 990481 agattctaat ttttagagaa aacccgttca ttggaacggg tttttttcat tagacggagc 990541 acaggcgttt tggttgctcc taaaaatgaa aatgtgataa aaaatccaag aacttttttt 990601 ctttcttatt ttcataaagg gcaatcgcgt aagcgccggc atagggcagc tgtacagact 990661 gataaggaat tctgatcatc tgtttctctg ctaactcacg ctttactgta gataaaggca 990721 gaaatgaaac tccgagtcct tccttgataa accgtttcgt tatatgtgtt tgagtgacct 990781 tcattgttct cacaaatgga aatgtcattc tgacttgacg gagcaagtcg tcccagtaat 990841 caggatgatt gtgggtcaaa agcaggtatt gttcgagcac ctctttggca tcaatttcgt 990901 tgtcttctat gaaacgctta tcgggcgggg caacaaggac gacagggtct ttgtataagc 990961 agtggcagct taaagaagaa gactgtacct ttaaacagct tagtccgata tctgcttccc 991021 cggctttaat cagtgacgcg atttccgctg attcgaaaat cgtaaccgcc atttctgttt 991081 ccgtattcat tgctgtgtac cgcttcatga cagaaggaag cactgtatct gcaataagcg 991141 gagaaaccgc gagctgtaag gtttgagagt agccttgtct cactctgtga agctctgcca 991201 tgctgttttc ataatcatca agaagcctga gcgcatacgg caaatacgcc ctgccttcat 991261 cagtcagctg gatttgcctg cctttacgct cgaacagctt gcagctgatt tctttttcta 991321 attgcttgat atgtacggtc acagtaggct gagataagaa aagcgtttcc gccgtttttc 991381 ggaagttctc atattttgca gcggtcacaa aggtgtgaag ccatttgaaa tccatttcta 991441 ttctccctct gattaatatt tttaattaat tccctttaaa atattgatta ttttttaaat 991501 attatattta ctataataac agaaaaggat agggggaata caaatggtac attacggatt 991561 aaagggaatt acatgtgtag aaacatccat cagccatatt gatggtgaaa aagggcgtct 991621 gatttacaga ggacatcatg caaaagacat cgcactgaat cacagctttg aagaagcggc 991681 ttatttgatt ttatttggaa aactgccttc aactgaagaa ttgcaggtat ttaaagataa 991741 gctggctgcg gaacggaatc ttccggaaca tattgagcgc ttgattcaat cactgccaaa 991801 caacatggac gatatgtcgg tgctgagaac ggttgtttca gcattggggg aaaatacgta 991861 cacattccat ccgaaaacag aggaagcaat ccggctgatt gcaatcacgc cttctatcat 991921 tgcatacaga aaaagatgga cgcgcggtga acaagcaatt gcaccttctt cccagtacgg 991981 acatgtcgaa aactactatt atatgctcac aggtgaacag ccttcagagg caaaaaagaa 992041 agcgcttgaa acctatatga ttctggccac ggagcacggc atgaacgcat cgactttttc 992101 ggcacgagtc acgttatcta cagagagtga tttagtgtca gccgtcacgg ctgctctcgg 992161 tacgatgaaa ggtccgctgc acggaggtgc tccttctgcg gtgacaaaaa tgcttgaaga 992221 cattggagaa aaggaacatg ctgaagcata tctgaaagaa aaactcgaaa aaggagagcg 992281 cttgatggga ttcggccaca gggtgtacaa aacaaaagac ccgcgggcag aagctttgag 992341 acagaaagca gaagaggtgg ccggcaatga ccgtgatctt gatcttgcgc tgcatgtaga 992401 agcagaagcg attcgtttgc tagaaatcta caaaccggga cgaaagctgt acacaaatgt 992461 tgaattttac gcagctgcag tgatgagggc catcgatttt gacgatgaat tgtttactcc 992521 gaccttttca gcaagccgaa tggtagggtg gtgcgcccat gtactggaac aggcagaaaa 992581 caacatgatt ttccgcccgt cagcgcaata taccggtgcc attcccgagg aagttctttc 992641 ataacatatt ttggcgttta ttcatttctg tcgtgtggta acgttcagta tcaaccacat 992701 gtctaggagt gatgaatgtg aacccaatgg acagacaaac agaaggacaa gaaccgcagc 992761 atcaggacag acagccgggc attgagtcaa aaatgaatcc gctgccgctg tcagaggacg 992821 aggattatcg aggaagcgga aaactgaaag gaaaagttgc gatcattact ggaggcgaca 992881 gcggaatagg gagagcagca gctattgcct ttgctaaaga gggggctgat atctccattc 992941 tatacttaga cgagcattcg gacgcagagg aaacacgcaa acggatcgaa aaggagaatg 993001 tccgctgcct gcttatcccg ggagatgttg gggacgagaa ccattgtgaa caagctgtgc 993061 agcaaacagt ggaccatttt ggtaaactcg atatcttagt gaacaacgcc gctgaacagc 993121 atccccagga cagcattctc aatatttcaa cagaacagct ggaaaaaacc tttcgcacaa 993181 atattttttc catgtttcat atgacgaaga aagctttgcc tcacctgcaa gaggggtgtg 993241 ccattattaa tacgacatcg attaccgctt atgaagggga tacggcgtta attgattatt 993301 ccagcacaaa gggtgcgatt gtttccttta cgcgttccat ggcgaagtcg cttgcagata 993361 aaggcatcag agtgaatgcg gtggcgcccg gtccgatttg gacaccgctt attccggcga 993421 cattccctga ggaaaaagtg aaacagcacg gcttggatac cccaatggga agaccgggac 993481 agccggttga gcatgcaggc gcctatgttc tgctggcgtc tgacgaatct tcctatatga 993541 cagggcagac cattcatgtg aatggcggcc gttttatttc aacgtaatca acgaaaaacc 993601 agctcaagag ctggtttttt gtgtggtgaa aaatttcaaa ataaaaaatt tgtcgatttt 993661 tctaacaatt ttgttttcat ttttgcaatt ttatatataa tattgagtag gagaaaggaa 993721 tgattcgcga ccagtacaaa tatagtagaa aaaaaagaat aatgaccatt gttactcatg 993781 aattcagaaa attcaaataa aatatataaa aatagatgat cgggagttga aggggaatga 993841 aagggagcgt ttttaggaag aaaagcattc aggatttaat cgctgcgacg agcggggaaa 993901 agtctttaaa aagagaatta ggggcatttg atttaacgtt gcttggaatc ggcgccatta 993961 ttggcacagg gatttttgtt ctgacgggaa caggcgcagt cacggccggt cccgggctga 994021 cgatttcatt tgttgtggcg gcgttggctt gtttattcgc cgccctgtct tacgcggaat 994081 ttgcgtcaag tgtgcctgtt tcaggttcgg tgtatacatt cacttatgcg acattgggag 994141 agcttatggc ctttattatc gggtgggatt taattttaga atacatgctg gcggtaagtg 994201 cagtgtcggt cggctggtct ggttatttcc aatcgttttt atcagggctt ggcattcatc 994261 ttccggttgc tttaacagcg gcaccgggcg cagtgaaagg cacctttacc ctgtttaatc 994321 ttcctgcatt cgtcattgta atggcgatca catatttgct ttatttaggc atcaaagaat 994381 caaaaagagt caacaatatc atggttatct tgaagatact ggttgttctg ctgtttatcg 994441 cggtggcagc cgtttacgtg aagccgcaca actggcagcc gtttatgcca atgggctttg 994501 gcggcgtgtt cagtgcagcg gcgctcgtat tctttgcttt tatcggattt gacgctgtat 994561 cctctgctgc ggaagaaacg aaaaatcccg cgaaggatct gcctaaaggc attattttct 994621 ctttactggt ctgcacgatt ttatatgtca ccgtatcagc catcatgact ggggttatcc 994681 cgtttgctca atttgcgggt gtggatcatc cggtttctct tgttcttcaa agcgcagggc 994741 aaaattgggt ggcaggcatc attgatattg gcgccgtgtt gggaatgaca acagttatgc 994801 tcgtgatgct ttacgggcag acccgcgtca tgtttgccat gtcgcgtgac ggacttgtgc 994861 cgggttcact ttctaaagtg catccaaagc acaaaacacc ttatgtagcc acttggtttt 994921 tcggaacgat gtcggcgctt ctcggctcac ttgttccgct ggatgaactt gcaaagctgg 994981 tgaacatcgg gacgttgtcg gcatttgtcc tgatttctgt ggcagttatc gttttgagaa 995041 agaaacagcc tgatcttccg agagctttta aatgcccggg agttcccgtg atcccaggcc 995101 tggcgattct gttctgcctg ttcttgattt taaatctggg atgggtgacg attgtccgct 995161 tcctagtgtg gctgttaatc ggcttggtaa tctatttcct gtattcaaga aagcattcaa 995221 aattaaatca ataacctttt gataaagaga gcggccatac aggccgcctc ttttctgttc 995281 ttggcaaatg aatctataga aatgaagaca aaaataagag ataatatagg ctggaaagga 995341 agtgacgttt attgtctgag caaaaaccag tccaatgggc ttcgaaaatt ggtttcgtca 995401 tggcagcggc cggctcggct atcggcttgg gcgcgatttg gaagttccct tacgtagcgg 995461 ggaccaatgg gggaggagcc ttttttctta tcttcgtgtt atttaccatc ctcttaggct 995521 atccgctttt ggtgggggaa tttatttttg gaagacggaa ccagacgaat gccattgatg 995581 catataaaaa agaagcgccg cgatcagctt ggtttcttac ggggtggatc ggcgtagcgg 995641 cgtgtttctt agtgctgtcg ttttacagtg taatcggggg atggattttg ctgtatatcg 995701 tgaaaacagc gtcaggatca ctgtccgggc tttctcaagc acagtatggc gctctttttg 995761 cttctattat ccaaaatccg gtgcagacgc tcgcggctca gcttgtcttt atggcactga 995821 ctgtactcgt tgtcgcaaga ggggttcaaa aagggattga acgggtaagc gcggtgatga 995881 tgccgatttt gtttttattg tttattctgc tcgttcttcg gtctcttacg cttaatggtg 995941 caatggaagg cgtaaagttt ctgcttgtgc ctcatttcgg cgatctgact ccggaatcca 996001 tattattcgc gctgggacag gccttcttta cgttaacact gggggtttcg gtgatggtga 996061 cctacagctc ctatttgccg aaaacacaaa atatccctcg ttcggcagcc tccattgtct 996121 tgatgaatat cattgtgaca ctcttggcag gtttggctat ttttccggcg gttttctcat 996181 tcggttttca gccaaatgaa ggaccgacat tgctgtttac agtgcttccg gccgtttttg 996241 aacagcttcc gttcggcaca ttgtttttta tcggctttct cgttgcattt ttatttgcag 996301 ccttaacctc agcattttcg atggttgaaa ttatcgttgc cacaatcgga aaaggggacg 996361 aaaagaagag aaaaaaactg tcatggacga gcgggctttt gatctttttg gtcggaatcc 996421 catgctgctt gtcttatggc gttttgagtg atgtgcacct atttggcaaa acgttttttg 996481 atattgccga ttttaccgtc agcaatgttt tgatgccttc aggcgctctg ttaatttctc 996541 tatttatccc gctgaaaatt tcgaaaagcg aactcttggc tgaaatgcga aatggatcaa 996601 atgcaggtaa agcattcttt tacacatggt tttatttgct tcgttttatc gtgccgcttg 996661 ccattattat cgtgttctta aatttaatcg gaattttatc attttaaaaa acaggctccg 996721 tttccggggc ctgtttttta tttaataaga tgatatcaac ggtgcccatg ccgttttcag 996781 tttttggatg ccgagcctga tgtcctcttc tgacaaaccg ccataaccga ttaagacaga 996841 agtaaaaggc gtctgttcta tatatgaggg agacacggga tagagggtta caccgtggtc 996901 agcggctgct tgtattgctt cttcctcact tgctggaaac aaaaggcgca gcagaatgtg 996961 aagccccgag ttcttaccga gaatctcaac ggtgtttccc agttcagagc gaatggcttc 997021 taacaggaca gcgtgttttt ttcggtataa gcttctcatt ctatttatgt gtttttgcca 997081 ctctccggtt tcgatgaagt ctgccagtgc caattgcgag tgggcagaaa cggtctgctt 997141 cattaactga acattgtttt ggatcggttc catgagttca gggggcacaa tcatgaagct 997201 gagccgcaag gaaggcagaa gtgactttga aaaagtgccc agatatatga ctctgccatt 997261 cggatcaaga ccctgtaaag acggaatggg atggccgctg tagcgaaatt ctccatcgta 997321 atcatcttct ataatgaatg aatttgtttc tgccgcccat gccagcagct cctgtctgcg 997381 ggtaatcgtc ataatggtcc caatcggaaa ctgatgcgaa ggagtcgtat acatgagata 997441 aggattctga cggtagagct catccggcag gacgccttct gcatcagaac aaatcggagt 997501 gacatccatg tgatttgctt caaacatcct tcttgaacgg tgaaagcccg gttcttcaaa 997561 gccgattttt gtacctggct ttagcgaaag gcaaagattt tgcagaagca cggtggttcc 997621 tgcgccgatg ataatctggc cgggttcaca atttactccc cgagacagcc tgacgaatcg 997681 ggcaatcatg tgcctgagtt cgtattctcc ttgagggtcg ccagaggtgt gaaacgatcc 997741 ggaatagcga tcaagacttt ttactatgct ttttctccat gcgttaaagg gaaagagggt 997801 cggatcaacg ctgccctgat ggaagtcaat agcaggtgcg tttttttgat gtaatcccgg 997861 ctgtacagac tgctgaaaat ggtcaggagc tgtcgggaat cctggttcta cttccgccgc 997921 gaaccagccg attttcggct tgcttttgac atagccctca gcagttaatt gctcataagc 997981 tcgttctata gttgccgtgc tgacatcgag caagctggag agcctgcgtt ttgacggaag 998041 tcttgttccc tttgtgattc gcgcatgtga aatttcttgt ttaaaaaagg tataaagctg 998101 ttcatacagc ggtgttttgc tctttttatc aagaaacggc gtaatatcca tctcatgtct 998161 cctttgtagc tggcatggtc attttttctg atattggcta tttggcaaat gccatttatt 998221 agctatgatc attgtaacga aaggaaaggg gattgagaag atgatccata tgaaacaatt 998281 aacctcgaaa gaagaatggg ctgagtcgta tccgattatg agtgaattga gaacagaact 998341 ggatatagag acgtatttac aaaggcttga agcctgtgtg cagaaagaat cgtatatgct 998401 gtttgcctta tatgaaaata cagcaatcag agcgctgtgc ggggctctgc cgagagtttc 998461 cattcataaa ggagagcact tgtggattgc ggatcttgtt acaacggcac cttgccgatc 998521 aaagggatac ggcaaaatgc ttttggatta tgcctcagac tgggcgagaa aagccggact 998581 cggttttgtc agtctttcat ctggccttca gcgtaaagac gcacatcgat tttatacaga 998641 taaaatgggt tttactatag aaagttattt gttccgaaaa ccggtataac gaaaaaagac 998701 gcctgaaaag gcgtcttttt taaaagccaa actgtaaatt cgtatctaca gatacaatgg 998761 tatacacaca aataatcaca aagagattaa ggatgacgcc gagcaggcct ggacctgtgc 998821 gccctctctt gatgaagagt tcaacaacgc cgaacggaac ggcagccatg gcgaacggaa 998881 gcatttgata ggaataaaac gtgacgttgc tgataatggc caaattcagc aacagcaggg 998941 acagaaccgc tgtcccgaca gagatccagc cgaatacatt gtgttcttta aaaattctta 999001 ccagttccat aattccacct cgccgacatt cgctgatttt acagatttat ttttcagcat 999061 gcgctggatt tccttggttg gccctgtaac gaccgaaccg tatacattga caccgttttt 999121 ctctacataa tctaatcggt tatctacatt caggtctttc cgttttgaaa tgacctgagc 999181 ccatttttcg tgtttggaca tgaatttcag ggcgttgata aactgatcgc cattcgactt 999241 gccttttgta ttaagggcgg ccaagaactt tgaatccttt ccaggatagc caagaggttc 999301 tgtggaagct gtcttatttg tgtttttctc tgtttcgatt gcgttccaca aaaagctcac 999361 atcatagcct ttgaatttgt tatacacgtc ttttgtcgga tatgcacggt catatgaaag 999421 gtagacctct gataccgttc cttcaggcaa tgtgcttaac gttttttctg cttttgcggt 999481 cgtttgttca gacttgtttg aaggatgtgt aaagtaatgg ccggttttat tcacttctaa 999541 gtcatagtag tttactgccg gcgcttttac tttgttataa aacatttcaa cccgttcatt 999601 ccctacggca gccgtcttcg tgccaatctg cttttgcagc gggaattccg tattcattcc 999661 aaatagcttc acttggcttt tcagtccgga agtatcaaca agaacattcg gcatggtcag 999721 ggctacagtg actgcggcag tttccataaa ctcattgccg gtgctgtgtt ttccacccat 999781 tccgtaatag aggtagcttc ccagcgtaca aagcggcaaa atcatcaatg tcgaaatgac 999841 ggcaagcaca gaaattcgca aataagactt gcgtttgccg taggctaaaa tcgctttttg 999901 tttttcagga ctgatgctga gatcccaatc gttatcgtcc tctagttcgc tgtcaatcag 999961 ttcctgatat acttcaagct tctcgagttc ttcctcaaat gcagtcattt cctggtcgct 1000021 catttcccca tttttatatt gatcaaaacg ctttttaaat tcttcattca tcattaacac 1000081 ctctattata aagtgctttc agccgctgtc tggcacgaaa taaaacactt ttaaaattcg 1000141 cctctgaaat attcataata tgggatgctt ctttgtagtt taactctttt aaataatata 1000201 gcgttaaggc ctcccgataa ttatcgggga gctcggacat ataaccagtc agcacttcct 1000261 ttatctctac ctgatgggca ggactttgaa cagcattttg aaagaggctt ccgattaagt 1000321 catcagaaat ggttacttct ttcttatgct ttctgacgta atcaatgaag gcgtttcgcg 1000381 ccacttgaaa aagccagggc tttactttgc tgtgatcata ggagtgaatg tgtatgtatg 1000441 cccgcataaa ggtttcctgc agtaagtctt cagcaagatg cttgtctttt gtcatggaga 1000501 gcaggaacct gtaaacatca ttcatgtaca tttggtaaat ttcatcgatc gtcactgcct 1000561 tttctcccct ctatgttata cacgcataag aaaggtttaa agttgcacat tacatgcaaa 1000621 cggctttttt atacctaatc aaacaccatt actatatagt acccaaaaat ggccgcaaaa 1000681 gatagtgcgg agaaaggttt aacatttttt ccagagggga aaagatagtg aaaaagtgaa 1000741 ggagtggcac aatggaatat accagtatag cagatacagg aatagaagcc tccagaatcg 1000801 gcctcggcac atgggccatt ggcggaacga tgtggggagg cactgacgaa aaaacatcga 1000861 ttgaaacaat ccgcgccgct cttgatcagg ggattacact gattgacacc gcaccggctt 1000921 acggcttcgg gcagtccgag gaaattgtcg gaaaggcaat caaagagtac ggcaaaagag 1000981 accaggtgat tctcgcaacg aaaacggctc tggactggaa gaacaaccag ctgttccgcc 1001041 atgcgaacag agcgagaatt gtagaggaag ttgagaattc tttgaagcgg cttcaaacag 1001101 actatattga tctttatcag gtgcattggc ccgatccgct tgtgccaatt gaagaaacgg 1001161 ctgaagtcat gaaggaatta tatgatgcgg gaaaaatccg ggcgattggc gtcagcaatt 1001221 tttcaattga gcaaatggat acatttcgcg ccgtcgcacc tctccatacg attcagcctc 1001281 catataatct gtttgaaaga gagatggaag agagtgtcct tccttatgcg aaagataaca 1001341 agataacaac attattatac ggcagtttat gcagagggct gttaacaggc aaaatgactg 1001401 aagaatatac atttgagggc gatgatctgc gtaatcacga tccaaaattc cagaagcccc 1001461 gctttaaaga gtatctttct gctgtgaatc aattggataa gctggcgaag acacgttatg 1001521 gaaaatcagt gattcacttg gctgtcagat ggatcttaga tcagccggga gcggatatcg 1001581 ctctttgggg agcaagaaag cctgggcagc ttgaggccct atctgagatt acaggctgga 1001641 cgctgaacag tgaagatcag aaagatatca atactatatt ggaaaatacg atatcagacc 1001701 ctgtcggacc ggagtttatg gccccgccga ccagagagga aatataacaa aagctgaggg 1001761 cgaatcctca gctttttggc gtttaaacga gagaaatctt aaaaattagt accaggtaat 1001821 aaaaaatatt gttataatag atgacagaaa gaatcattga ttacgacaaa ggaagtgcga 1001881 tatgtataag ttttgtgcaa atgctttaaa agttattctt tctcttcgcg gaggagtgaa 1001941 ggtgtataac aaagaaaacc ttccggccga ttcaggtttt gtcatcgcgt gtacacattc 1002001 cggctgggtt gatgtgatta cactcggagt cgggattctt ccttatcaaa tacactacat 1002061 ggcgaaaaaa gagctttttc aaaataaatg gatcggttcg tttctgaaga aaattcatgc 1002121 ctttccggta gatcgggaaa atcccgggcc aagcagtatt aaaacgccga ttaagctgct 1002181 gaaagaagga gagatcgtcg gtatcttccc aagcggaaca agaacctctg aggatgtgcc 1002241 tttgaaaaga ggtgcggtga cgattgcgca aatggggaaa gcgccgcttg tccccgctgc 1002301 atatcagggc ccttcaagcg gaaaagaatt attcaaaaaa ggaaaaatga agctgattat 1002361 cggtgagcct cttcaccagg ctgattttgc ccacctgcct tcaaaggaaa gacttgcagc 1002421 aatgacagag gctttgaatc agcggattaa agaactagag aataaacttg atcagctata 1002481 aggcgttctg agagattgtc ctgaaactgt gaaaataaga aaagcaccct atacaaggtg 1002541 cttttcttat tatgcttcct gctggttagc tgtctccaga agttcttctt cttgaagctt 1002601 tttcacttca atatatgcga cgtggtggcc gtcaatttca ttaatgatga attcgcagcc 1002661 ctcttcgatg atggaatcat ctttttcaac atcgtatttt tgagtaagga accagccgcc 1002721 gattgtatcg acttcttcgt tctctaaatg gatgcctagc aggtcgttta cttggtcaat 1002781 taacactttt ccgtcaagaa tataatggcc ttcgccgatt ttgcggattt cgctaatttc 1002841 atcaatatca aattcgtcgc ggatttcacc gacaatttcc tcaatgatgt cctcaaccgt 1002901 cacaagcccg gcagtaccgc cgtattcatc agacaaaatg gccatgtgga ccctctcttt 1002961 ttgcattttg acaagcaggt cttggatcgg cgcagattca atgacatgaa tgatagggtt 1003021 gacgaattga gaaatggtgg aatcaacaga tacctcaccg ctgatgcagg cggtcagcac 1003081 ttctttaatg ttaataaccc cgataatgtt atctttatcg ccctcttcca cagggtagcg 1003141 ggtatatttt tcaatctgaa tgatgtccat catttcagaa atcttgatat catgcggaag 1003201 gctgacaatt tcggtccgcg gaatcataat ttctttcgcg agcctgtcgt caaattcaaa 1003261 gattttattc acatatttaa actctgattg gttgatttca ccgcttttat agctttcaga 1003321 caaaatgatt cgcagctctt cttctgagtg agccagttcg ttttctgaaa cggtctccag 1003381 gccaaatgct ttggtcaata accgtgcgga attgttcaaa agccaaatga atgggaacgc 1003441 gatgcggtaa aaccaaatca gcggtttcgc aaacagcata gacactgctt ccgccttttg 1003501 gatagcgact gttttaggtg caagttctcc gacaacaacg tgtaagaacg tgataatggc 1003561 atacgcaaaa ataaacgata tgacatgtga aagggaacct ggaacgttca tttggacgaa 1003621 aagcgggtga agcagccttt cgatcgttga ttcacctaaa acccctaatc cgatggaagt 1003681 caatgtaatt ccgagctgac acgcagataa atattcatca agatgcgtgg tcactttttt 1003741 tacggctatt gctgctttat ttccttccgc gatcagctga tcgatccgtg agcctctgat 1003801 tctgataatg gcaaactcag atgccacgaa aaatgccgtc agggcgatta aaacagcaac 1003861 taaaatcaaa ttcactatgt ccaattagaa ccttcactct agcaatgaga atgaaggtaa 1003921 cacctcctgt tagataaaat ggttttaact taacagcagc ataaatgatt ggaacacggc 1003981 gagcttttca ggcgggagtt tgcttttcag cttgtcacga tcctcgggct tcagccgttc 1004041 aaaccgatgc aagattccgg agatgttttg attcatatga tcaatttcta atgccagatt 1004101 tccaatttca tcatcaagtt tagctgaaga gggaaactgg ttctccagtc gatctttaat 1004161 atcggacagg gccaatcgct gcttcttgca atctacaata aatataagtc gtttgagtgc 1004221 attttcgtcg tagtaacggt aatttgaaca ggatctggcc ggcgtaagca gaccgagatt 1004281 cgtataataa tcaactgtcc gtttcgttac tccggcgagt gccgctagtt cactgatgcg 1004341 ataagtctca gccccatcta tatccctccc aaccatcacg ttatagttat gagaatagtt 1004401 taatatatga acggtgtctt gcacaagttt attgtttttt ttagaccgga attggaagtt 1004461 gtggaattca tcatctgatt gaagtaacat aggaagatag aattttcaaa tttttatatg 1004521 cggaagggac agatgaaatt ggctgggtta tcccgggaag ttgaagaaaa cttaaataaa 1004581 ggatcatgga ttcgcaagct gtttgatgaa ggtgcaaggc tgaagaagga gttcggggaa 1004641 gaccaggtat ttgatttttc actcggcaac ccgattgttg aaccgcctga agcttttaag 1004701 agagcgttaa tagaggaagc tgaaaaaggc agccacggat acatacaaaa ccaagggctt 1004761 cttgcagcga gagaaaaagt cgcgcaattt ctgggctcgc gttttgaagc tgatttctca 1004821 gcggagcgca tcgtcatgac ggtgggcgcg ggaggcgctt tgaatgttgc gttaaaaagc 1004881 atcgtaaacc ctggggaaga ggtcattatt cttgcacctt attttgccga atataagttg 1004941 tatattgaga actacggggg aaaagccgtc agctgcccgt tgacaagccg gtttgagatc 1005001 gacattgaag cggtaaggca atcgatcact ccacagacga aagggctgat tctcaataca 1005061 ccgcataacc ccacaggcac tgttctcagc cagaaaaata tagacgattt aggcgcttta 1005121 ttaaaagaaa tagaagagaa gagcggccag acgatttatg tgctgtttga tgaaccgtac 1005181 agtcaattaa tctatgatga agagctggca aatccgtttc aatcgtacca tcgtgtgata 1005241 ttggccagct cattcagtaa agatctcggc atagccggag agcggctcgg gtatatcgga 1005301 ttggacagcc gaatgccgga tgcggacctt ttgatcaacg cttttgtgta ttgtaatcga 1005361 acgcttggat ttgtgaatgc ccctgtcatg atgcagcggg ctgtggcacg aatggatgat 1005421 ttaagagtag acgcgagcgc ttataaagag cgccgggatt taatggtaga cattttaaaa 1005481 gaagccggtt ttgaatttga aatgccaaag ggaggtttct ttgtttttcc gaaatcgccg 1005541 attgaagatg aagttgcatt ttgcgtgcat gccgcccaaa aatacaaatt attaattgtg 1005601 ccgagcagcg gttttggaat gagcgggcat ttccgattat ccttcagtgt gccgatcgag 1005661 cagattaaaa actcacggga cattttcatt tctttatata aagattttgc ttaagaaggc 1005721 aaagaaaaga aaacagtttt caaggctgtt ttctttttat atccgcaaaa tccttcctct 1005781 tccaatccag acaggcgcag aattgacaag caggcatgca gttaaggctt tcttcatgat 1005841 aaaagtctaa aaattaaaaa tcatttttgg aatgagttgt gttacaataa aatatacaat 1005901 ttataatcaa actttgactt ttggaggtgg tatgatgggg ccctctgctt aggcaacaat 1005961 acaccgcgta cctcaatgtt aaggaaaaat gattatatca ggaggtgact ccttatcctt 1006021 tgttgagagg atagggttaa atggacgata ttgacagtct gattttaatt ggcgtgctca 1006081 ttgctttaac cgcgtttttc gttgcaagcg agtttgcgat tgttagagtg aggagatcca 1006141 gaatagatca gcttatcaca gaaggaaaca aacgggcgat actcgcaagg cgtgtcatta 1006201 cagatttgga tgaatattta tccgcatccc agctaggcat tacattgaca tcaatcgggc 1006261 ttggcgtact gggtgagccg gcctttgaac ggctgctgca tccactgttt gaaccgctcg 1006321 gcttgccgga ctcggtttca catgcagtct cttttgcagt cgcgtacggc ttgatcacgt 1006381 tcctgcacgt tgttgtaggt gaactggccc cgaaaacggt cgcgattcaa aaggcagaac 1006441 agctgacttt actgatagcg ggccctttgc gtttattcta tttgctcctg tttccgttta 1006501 tttggatcct caatggatcg gcgcggcttt tatgcgggat gttcggtttg aagcctgcgt 1006561 cagaacatga tggttcccat tctgaggaag aactcaggat gctgttatct gagagtttaa 1006621 aaaacggaga gattaatccg tctgaatata aatatgtgaa taagattttt gaatttgata 1006681 atcggatcgc caaagaaatt atgataccgc ggaaggaaat ggctgctgtg tcaactgaga 1006741 tgacgatggc cgagatgctt gaagtcatgc tgaaggaaaa atacacgcgc tggccagtca 1006801 cagatggaga caaagacagt gtgctcggtt tggtcaatac gaagcatttg ttttctgatt 1006861 tgctgtttat gacagaagaa gaacgaatga agatgacgat ccatccgtat gtgaggccgg 1006921 tcatcgaagt gattgaaacg atcccggttc atgacttgct gattaaaatg cagcgcgagc 1006981 gcattcatat ggctatattg tcggatgaat acggaggaac ctcgggactt gtgacgacag 1007041 aggatattct tgaggaaatt gtcggagaga tccgagatga atttgatgaa gatgaacagc 1007101 cgctgatcca aaagcttggc gacggccatt atgtgatgga tggaaaggtt cggatcgatc 1007161 aggtgaacag ccttcttggc gcatcgattc aagaagacgt cgatacgatc ggcgggctga 1007221 tattaaaaga aaacatcgat attgaggctg gtgaatccat tcgcatcggt tcatatacga 1007281 taaaggtgct gaagatggac ggccgattaa tcaagcaaat cgatataaaa gaagaagccg 1007341 gcaacacaac cgggattacg gcgcaccaca agctgccgct gcccgagcct gtgatgctga 1007401 acagtgcaac cttgagcgag aaataagctc aaggtttttt tatattgtga ttgtccagcc 1007461 gcaccaaaat gcaaaaagcg acccgcaaag tgtcaggacg atgtacaaga tgctttcttt 1007521 tacacgtttg gccataagga gttgaatagt ttcaacgctg aatgtggaaa aggtcgtaaa 1007581 ggcgccaaaa aaccccgtgc caatgataag cgagaccgaa gcatttgcaa cgtgaagtcc 1007641 tgtaaatatt ccgagcccga gagctccgag aatattgact gtcagtatgc caatgggcag 1007701 gctgagacct ttggttttgg cggttatgac attgccaagc cagaagcgaa gcattgcgcc 1007761 aagtccgccc cctatgaaaa tacccgctag tgtcattttt cctgcagccc ctttctttgc 1007821 tgaatgcctg ctatgcgccg tcccacaaaa acaccaatca gtgcaaatat gatccctgat 1007881 atcaatgagg ctgccacata taaaagagcc aatgagggtt gtccttgcaa aagcatcact 1007941 gtttccttag aaaacgtgga cattgttgtg aagcctccgc aaaagccggt gcctaaaaaa 1008001 gccgacagca gaggccgttt tgccccgatc ataaaaaatc cggtcaaaat gcctaataga 1008061 aggctgcctg ccgcattttc cagccaggtt gccgccggga actgaccggt gtgtatccat 1008121 aagtttaatc cgtatcggag gcaggcgcca agcgcgcctc cgataaaaac cgcgctatat 1008181 attttcatgt ttgccatcct ttatgatgaa atccgggtaa tctgtaacga tgccgtccac 1008241 gcccatggct tgtaattttg ccgctgtctt ttgattgttg acagtccatg caaatatgtt 1008301 taagccattt ttattgatgg agccgatcat cagacggtta agccgtgtgt gttttatatt 1008361 gacatagttt gcaaaagagc ggaaggcctt catctgattt ctggacagca tgccaaagtt 1008421 gggccttgta atgaccgctg tcggaatcga aggataaagc tcgcggaacc tttggacgga 1008481 gcggaactga aaggattgaa caatattatt gatagaaaaa gaaaattgcc ctaatagctg 1008541 tcccacctct tcttcaattc cgacttgaga cggatggcct tttagttcaa ttaaaaggcc 1008601 gatttttttg tggtagcgct tgagcaccgc ttccagggtt ggaatacgct ctccttgaaa 1008661 agcgggaccg taccagcttc ctgcatcgag tttttgcaat tcctccaagg taaaatcctt 1008721 aacaaagccc gatccgtttg ttgttcggtc aaccctgtca tcgtgtatca caacaatctg 1008781 cctgtctttt gtaagctgga catccagttc gatcatatct gcattcattt tcaccgcaag 1008841 gtcaaatgcg gcaatcgtat tttccggagc gtagccggat gctccgcgat gggcaatgat 1008901 gtacaagcta agtcagctcc tcgtatgggc atttctgtta ttgtatcaaa tccatatatg 1008961 caccgcgata caaactggtg aattttttct gccatatcgg aatggtccgg gctgaggaat 1009021 gcgtataact aaaaaaagac actcagcgta tcagaacaca tttcgtcaga aaattaggtc 1009081 tttcgacatg ttcacaacaa aatatgatcc tttataatag caaaaaagga ggcgagatca 1009141 tgggaaaagg gagaatcaga gtggaggaaa gaattaaagc cgaaacggat gctgaaatgc 1009201 aaaaagcaac tctccttgat cagacacaaa cgaaaaaagg taagtgactg tccctattga 1009261 atctggctga tagatgaatt gagaaatgac cccggcgttt cgccggggtt ttgtgctgca 1009321 taagacattt aaatgaacat ccttacgaat attttagtat aataaacaat tgattgggat 1009381 agaggggaga cagtcatgcc ggattatctg cagcagtatt ttacgcttga taacatcata 1009441 caaatcggca tcagcttggc gattttgctg gtgtttctta tacttagaaa attattcaca 1009501 agatattttt ttaacctgct ttttaatttg acaaaccggc cgaaaacaga aatttttaaa 1009561 caggtggttc tggcgtttga taagccggcc agatggtttt ttgttgccct tgggctgttt 1009621 ttagcgatcc ggtattcacc gtttttagat gagcaaatgc cggtcatcag caaaatatac 1009681 cgctcactga ttgtggcgct cttgtgttgg ggtctttgta atttgaccgc aacatcgtcg 1009741 tttatcttcc ataaggtgaa ccagcgcttc gagcttgaca tggatgacat tctggccccg 1009801 tttttatcca aattgctccg ttttgtgatc attgcgctca gtgtcagtgt gatcgctcag 1009861 gaattcaatt atgatgtcaa cggatttgta gcgggccttg gtcttggcgg actggctttt 1009921 gcgcttgccg cgaaggatac catcagcaac ttcttcggcg gtattatcat tattactgaa 1009981 aagccgttta caattggtga ctgggtggag acgtcgacag taacaggatc agtcgaggat 1010041 attaccttta ggagcacgag attcagaaca gcacaggggg cgcttgtaac ggtgccgaac 1010101 tctacgctgt cgatggaagc gatcacgaac tggacaagaa tgaccaaacg ccagattacg 1010161 ttttccatcc atgtgtccta cgctacgccg attgagaacc ttgaacgctc cattcattct 1010221 ctcagaacaa tgctcttaga gcatgagggc gttgataatg aaataatcat ggtcaacttt 1010281 gatacgtttg ccgacagcta ctacaattta ttttttaact tctatacaaa aacgacggtt 1010341 tgggctgaaa accttaatat tagagaggat atcaactata aaattattga gattttaggt 1010401 gcagaaggcg ttcagtttgc atatcccggc caaatggttg ttgtcaagca aaagcacgaa 1010461 agcgaccaat tccaggtgaa tctaaataaa gaggaaaagg aacgggctta aaagagagac 1010521 ttcgtctgac agaggcggag tctttttcat ggtaaaataa gagaaaaagg cggtgttgag 1010581 ttggaaacat tcaaaagtat tctacatgaa gcacagagaa ttgttgtgct gaccggagcg 1010641 ggaatgagca cagaatcagg gatccccgac tttcgttcag cagggggcat ttggacggag 1010701 gatgcctcaa gaatggaagc gatgagcctt gattattttt taagttatcc gcgtctgttt 1010761 tggcccaaat tcaaagaatt gttccagatg aaaatgagcg gcagctttga accgaatgaa 1010821 ggccatttgc ttttagctga gctggagaag caagggaagc aggtcgatat tttcacgcaa 1010881 aacattgacg gtcttcataa aaaagcgggg agcaggcatg tgtacgaact gcatggttct 1010941 atccagacag cagcttgtcc ggcatgcggc gcccgatatg atcttcccca tttgctggag 1011001 cgggaggtgc cggagtgcac ggcggccgga aacaatgggg acatttgcgg aacggtatta 1011061 aaaaccgatg ttgttctctt tggcgatgcc gtcatgcact ttgacaccct ttatgaaaag 1011121 ctggatcaag cagatctttt attggttatc ggcacgtctc tcgaagtggc tccggctaga 1011181 tttgtgcctg aggatgcaag cctgattccc ggcatgaaga aagtcatcat aaaccttgaa 1011241 ccaacgtatt gcgacagctt gtttgacatg gtcatccatc aaaaaatcgg cgagtttgcc 1011301 cgaagtttgg gcatgaaaaa gtgagccgct ttatgcgcct cactttttta ttcatgaaca 1011361 ggaaccattg tgtcctctaa cactccgaag gaatagcctt tttcttttaa tttattgatt 1011421 agtaccggca gcgcatttac agtagcagga agatcatgca tgagaattac atttgggcgg 1011481 cttgaagagc tgtgttccat attctcaagc tgctgtaata cggcggtcac atactgtgaa 1011541 ttccggtatt tccagtccat gctgtcgatc gtccaatccc agtacacaaa cccatctttc 1011601 tccagattgc gaatttgtga ggcggttagt gacggcttgc ttccgtatgg cgttctgaca 1011661 agatcggttt tatatcctgt aatgtcctgc agcgtgtcac gcgcctcctg catttctttt 1011721 agcggagatg tcggtgtttg atagaacaat ctgttattgt gggtaacgcc atgtaaaccg 1011781 agtgcgtggc cttccttttc tgctcttttc acagcctgct tgaattcgtt catccgcggt 1011841 gacagcataa aaaacgtcgc ttttacatca gcgcttttca gtacgtcgag caagcgggtt 1011901 gtaacggctg aagggccgtc gtcgaaggtt aagtaaaccg ttttatctcc catgttctgc 1011961 tttgtctgca gatgttttat caggagatcg ggggagtcgt ttttcagctt aaggctttcc 1012021 ttctcatctc gaagctggcc gtttgttgtg acagtgactt cctttgcttt cgttgaactg 1012081 ttggaataac ccaaaatcac cataagcaaa agcagcacac ataaaactgc taaacttgca 1012141 aatttaaaag caagcgaaac tgcagaagga gaagcctctc ctctcgtttg tcgcataaca 1012201 atctctccat tggcataaaa tctctacata atgctgtaca gcaggcagct tatgaagatg 1012261 ccttatgttt acaacctatg tattaccagt caagtataca ggaataaaac tggaaagcac 1012321 atagaaaatt tgtcgaaatg tcagatttta aggaaaaaat aaactccttt ccgctataga 1012381 tctcttgatc tttctgtttt tcagcttgtc caatatggta gaattagtga taatgacagc 1012441 ttgaatgaca tcagggacat ctcgaaaagg gagggctttt atgaaggttt tagtcaatgg 1012501 ccggctgatt gggcgcagtg aagcatcaat cgatttggaa gatcgcggtt atcagtttgg 1012561 tgacggcatc tatgaagtga tcagggtgta caaaggagta ttgttcggct tacgtgagca 1012621 tgcagagcgt tttttcagaa gtgctgctga aatcggaatt tcactgccat tcagtataga 1012681 agatctcgag tgggacctgc aaaagcttgt acaggaaaat gcggtcagtg agggagcggt 1012741 atacattcag acaacaagag gtgtggcccc gcgaaaacac cagtatgaag ccggcctcga 1012801 gccgcagact actgcctata cgtttacggt gaaaaaaccg gagcaagagc aggcatacgg 1012861 agtggcggcc attacagatg aggatcttcg ctggttaaga tgtgatatca aaagtctgaa 1012921 tttactgtat aatgtcatga cgaagcaaag ggcctatgaa gccggagcat ttgaagccat 1012981 tttacttagg gacggcgttg ttacggaggg tacatcctct aacgtttatg ccgttatcaa 1013041 cggcacagtg cgaacacatc cggctaatcg gctcattctc aatggaatta cacggatgaa 1013101 tattttagga ctgattgaga agaatgggat caaactggat gagactcctg tcagtgaaga 1013161 agagttgaaa caggcggaag agatctttat ttcgtcaacg acggcagaaa ttattccggt 1013221 cgtgacgctc gatggacaat cgatcggaag cgggaaaccc ggaccggtga ccaaacagct 1013281 tcaggctgct tttcaagaaa gcattcaaca ggctgctagc atttcataaa tgaacgaaga 1013341 aaagagcccg ctttttacag cggggctctt tttatttttt aacaaatcca atcaaaatgg 1013401 agatcattgg cgatatatag aggaagaacg taaatgggat gtagtctatg actggaacac 1013461 caagtgcgct cgccataaat gcgccgctga cgccccaagg aatcaatggg ttaattaatg 1013521 ttccgccgtc ctctaatgat cttgtcagaa attttcgctg gatgtttcgt ttgtcatata 1013581 aagatttaaa tgattgtccc ggtattaata tcgataaata ctgttcgccc gttgccaagt 1013641 tgacgccgat gcttgagcag acagttgctg caacaagacg gccttttgag cggatgcctt 1013701 tcatgacgcc ttccaatagt gcagaaatca atccgatttt ctccatcaat ccgccgagtg 1013761 caaaagcaat cataatgaga gagacagagc ccatcatgga ttgcagtccg cctctgttaa 1013821 taattttagc ggctgcctca ttgtcagttt cgaaagttgt gccattttgt aaagctgtca 1013881 taaacgcctg caggctgctg tagggtacaa aaatagcagt caaaattccc gaggaaataa 1013941 ttccggcagt cagaacgggg attactgata cccgtttcat tgccagcaaa acgactaaga 1014001 gcggagaaag aagggcccac ggtgtcacgt ttgcagcatc ttttattccg gttatgacct 1014061 gctgaatatt atcggttgaa gcagcgtccg ctgacactga tgaaccgaga aagtaaaaca 1014121 gaacgacagt gatgagcaaa gctggaatgg ttgtgcccat catatggcga atgtgttcaa 1014181 agattggtat ttcgcctatt ccggctgcaa agttggttgt gtccgacatc ggcgacattt 1014241 tatccccaaa acaagcgccg catatgactg cgcctgctgt ccattcaagc ggaacgccag 1014301 ccgcgctcgc cacgccgatc agcgctactc cgattgtgct tacagttgtc agacttgagc 1014361 caacaagtgt gctgatgatc atacatgaaa acaaagcagt caacagaagg tggcttggtt 1014421 caataaagga tagggcataa actgtcatag tcggtattgc gccgctgtac atccaggcgc 1014481 cgattaagat gccgatcagc gctagaacaa taatcggctg tacgccgttt ttgatcccgt 1014541 ctacaatccc tttttcaatg ctcttccagg gaaatccaaa ccataaagct gctgctgaaa 1014601 gcatgacaac acttaaaaac agcgggatat gaggttctac atgaagcaag aataagcaag 1014661 aaataataat gcacaacatg aatataaata aaccgacggc taacggaaac gtcagctttt 1014721 tttgagaatc caaaataaca ccccatattt atctttaatg cttttgtgct tttgggcacg 1014781 aaagcattat aacagaaaaa aacgaaaatc tatgtttttt cacaattatg aatataaaag 1014841 aagtgagcac agggcgtgct cactttacaa tcaggacggg tatatccgat ttcgctgaaa 1014901 gcttttcact tacacttccg aatattagct ttttcagcct gttttggtct ctgcttccgg 1014961 ttacgatcat atcggcagaa atgcggtttg catgctcgat aattgattca gccggatcgc 1015021 cttctaatat atcgatatct ccatctgcct gctgttcatt cagcatcatt ctggcttcgg 1015081 cgatgacttc ttccgtacgg tcttcataga tcattggctc aggtgatgtt acatccgata 1015141 tcagcggatc aggaacactt gtcatgcctc cgctgatata gcttgcctca gctgcgggtc 1015201 tgggcgggtc gatgacggtc tgattgtctt tcatatcatg tgaatgggcg acggtaatag 1015261 cggcatttac ggttttagca agatcaatgg ctgtcagaag cgctttctta ctattttcac 1015321 ttccgtcaaa cgcaacaatg atacggtcag catggaacat ccttctcacc ctttcaaagc 1015381 gtcttacaac actactaccc gaatttgagc acaattaacc ttttcctatt caagtaatga 1015441 ttgacaataa aaggttttgt ttatatgatg ataaaaagat gaaatcagaa tggaaggagg 1015501 gtttgctatg ccaaggaatt tgcgtgttta tcaaacagtt tcatattggc gcggcaaacc 1015561 ttttgttctg ttttcgtgaa cggtttttta ggtcggaccg cgcgctgaaa agcgctgtgc 1015621 gtaacatatc ggttaaaaaa ggcatggagc tgacgcttca tgcctttttt atatacaaaa 1015681 tctaaggaaa gacaggtgta tgggatgtga agacaaatac agaggcgagg gcagttcgtg 1015741 ccaaactgga tgaaaaaagc tgcaaggaaa aaatagaagg cggctgatga ggagatgggg 1015801 atagatgttt tcagttttga aaaagcttgg ctggtttttt aaggcgtact ggctgcgcta 1015861 tacgattgcg attgtccttt tattagcagt caatgtcatt gaaatgtttc cgcctaagct 1015921 cttggggaac gccatagatg atatgaaagc aggggcattt actgcggaag ggctgctgtt 1015981 ttatatcggt atcttttttg tgctgacggc ggccgtgtat atcatgtctt atttttggat 1016041 gcatcagctg tttggcggag cgaatctgat ggagaaaatt cttcgtacga agctgatggg 1016101 gcatttgctg actatgtcgc cgccgtttta tgaaaaaaac cgaacaggcg atttaatggc 1016161 acgagggaca aatgatcttc aggccgtcag tttaaccaca gggtttggca tcttgacgtt 1016221 agttgattct acgatgttta tgatgacgat ctttttgaca atggggtttt tgatcagctg 1016281 gaagctgacc tttgccgcca ttatcccgct tccagtcatg gcgattgcaa tcagtctata 1016341 tggaagtaaa attcatgagc ggtttactga ggcccaaaac gcgttcgggg cgctgaatga 1016401 cagagtgctg gaatctgttt caggcgtgcg ggtgattcgc gcgtatgttc aggaaacaaa 1016461 cgatgttcgc cggtttaatg aaatgaccgc tgatgtttat cagaaaaata tgaaagtggc 1016521 ttttattgat tcactgtttg agccgacggt aaaactgctt gtcggcgcaa gctatctgat 1016581 tgggctcggc tacggagcgt ttcttgtatt ccggaacgag ctgacgcttg gagagttagt 1016641 gtcctttaac gtttatctcg gcatgatgat ttggccgatg tttgcaatcg gtgaactcat 1016701 taatgtgatg cagcgcggca atgcgtcatt agatcgggta aatgaaactc tttcttatga 1016761 aacggatgtg acagatccaa aacagcccgc tgatcttaaa gagcctggag atatcgtttt 1016821 cagtcatgtc agctttacat atccaagctc aacaagtgac aatcttcagg atatttcatt 1016881 tacggtgcga aaagggcaga ctgtcgggat tgcaggtaaa accgggagcg gaaaaacgac 1016941 aattattaag cagcttttgc gccagtatcc tccaggtgaa gggagcatta cattttcagg 1017001 tgtaccgatt cagcaaatcc ctcttgaccg tctccgcgga tggatcggat atgtgcctca 1017061 ggatcattta ctgttttcac ggactgtaaa agaaaatatt ttatacggaa aacaggatgc 1017121 aactgataaa gaggttcagc aagccattgc cgaagcacat tttgaaaaag atttgcacat 1017181 gcttccgtcc ggtctggaga caatggtcgg tgaaaaaggc gtggcactgt caggcgggca 1017241 gaaacaaaga atttcgatcg cgagagcact catggcgaat ccggaaatct tgattctgga 1017301 tgattcactt tccgctgtag atgccaaaac agaggctgca attatcaaga acatcagaga 1017361 aaaccgcaaa ggaaaaacga catttatttt gacacaccga ttatccgcgg tagagcacgc 1017421 tgacctgatc cttgtgatgg acggcggcgt cattgctgag agaggcacgc atcaagaact 1017481 gctggccaat aatgggtggt accgggaaca atatgaaaga cagcagctgt tcactgcgga 1017541 agaaggggga gcaggggcat gaaaatagga aaaacgttat ggagatacgc acttctttat 1017601 cgaaaattgc tgatcacagc cgtccttttg ctaactgttg ccgtcggtgc agaactgact 1017661 gggcccttta ttggcaaaaa aatgatagac gaccatatcc tcggcattga gaaaacatgg 1017721 tatgaagctg cggaaaaaga taaaaatgcc gttcagtttc acggcgtctc atatgtcaga 1017781 gaggaccgat tgcaggagcc tgtttcaaaa gcaaaagaag cgcatattta tcaagtggga 1017841 atggcgttct attttgttga tcaggctgtc agcttcgacg ggaatagaac ggtttctgac 1017901 gggaagctga cgatcacaaa cggagacaag agccgggcat atgctgccga aaagctgact 1017961 aagcaggaac ttttccagtt ctatcagccg gaaataaagg gaatggtgtt actgatctgc 1018021 ctgtatgggg gcttgcttgt gttttcggta ttctttcaat acggacagca ttatctgctg 1018081 cagatgagcg ccaatcggat tattcaaaag atgaggcagg acgtgttttc gcacatacag 1018141 aaaatgccga ttcgctattt tgacaacctt ccggccggaa aagtcgttgc gcggattacc 1018201 aatgatacgg aggctattag ggatttatat gtcacagtgc tttcaacatt tgtgacaagc 1018261 ggaatctata tgttcgggat attcacggct ttgtttctgc ttgatgtgaa gcttgcgttt 1018321 gtatgtctgg caattgtgcc gattatctgg ctgtggtcgg tcatataccg gagatatgcg 1018381 tcatattaca accaaaaaat ccgctcgatc aacagtgaca ttaacgcaaa aatgaatgag 1018441 tcaattcaag gcatgaccat tattcaggct ttccgccatc aaaaggaaac aatgagagaa 1018501 tttgaggaat taaatgaatc acatttttat ttccaaaaca ggatgctgaa tttaaactcc 1018561 ttaatgtccc ataatctggt caatgtcatc cgcaatcttg cgttcgtctg tctgatctgg 1018621 cattttggcg gtgcgagcct gaatgcggcg gggattgttt ctatcggtgt gctgtacgcg 1018681 tttgtcgatt atttgaaccg gttatttcag ccgatcacag gcatcgtcaa tcagttttca 1018741 aagctggagc ttgcaagggt ctccgccggg cgtgtttttg aactgcttga agaaaagaat 1018801 acggaagaag cgggtgaacc ggcgaaggag cgcgcgctgg ggcgggttga atttcgtgat 1018861 gtgtcatttg cgtatcaaga aggtgaagag gtattaaagc atatttcctt tactgcgcaa 1018921 aaaggcgaaa ccgtagcgct cgtcggccat accggatcag gaaaaagctc gattttgaat 1018981 cttctgtttc gtttttatga tgcgcaaaaa ggtgatgtct taattgatgg aaaaagcatt 1019041 tacaacatgt caagacagga actcagatcc catatgggta ttgtgcttca ggacccgtac 1019101 ttattctcgg gcacaatcgg atctaacgta agtctggatg acgaaagaat gactgaagaa 1019161 gaaataaaaa atgcactgcg gcaagtcggt gctgagcctc ttcttaagaa gcttccgaag 1019221 ggcattaatg agcccgtgat tgaaaaaggc agcacgctat cctctggaga gcggcagtta 1019281 atttctttcg ctagagcttt ggcgtttgat cccgcgatct tgattttaga tgaggcaacg 1019341 gcgcatattg atacagagac agaggccgtg atccagaagg cgcttgatgt cgtcaaacaa 1019401 ggacgcacca ccttcgtcat cgctcaccgg ctttcaacaa tcagaaatgc tgatcagatt 1019461 ttggttcttg ataaaggaga aattgttgag agagggaacc acgaggaact gatggcatta 1019521 gaaggccaat attatcaaat gtatgaactg caaaagggac agaaacattc cattgcataa 1019581 cgctcaaaaa cccaaaacaa tcgtgttttg ggtttttggt ttatgtagtc aataagccag 1019641 tccgacacgg tttccgacat actcacctgt aacgagctca cgatataaaa agtccgcagt 1019701 atcgccgacc gaaatgcttg tgccgccctc aggcaaaacg ttacgctccg tacgataaac 1019761 gccggttgct gttccgtccg ggaggtaagt ggggcagatg attgtccagt ctaatgatga 1019821 ttctttaagc atttcgtata cttttgcatg ctccttggct gcgcgggtct gctttcgttt 1019881 cgattcattt gtttcaaacc ggtattttcc cggttcatat cgggaatcta ggatccctgc 1019941 ggtgccgatc gtaataagcc gtttgatatg ctgttcctcc ataacggaga gaatgtgtgc 1020001 catagcagtt gacaaggtat catcaccatc tgtgcctaga cagctgatca cgatttcagc 1020061 attctccatt atttttttca catcttctaa gcggcgggcg ttccccatga cagttctgtc 1020121 ttttgaaagg ggaagatcag catgttgaga tctgatcaga gcgaaaatat caaatctttc 1020181 atctgctgca gcttgtgtta aaaaggcttg tccgacgcgg ccgctggctc ctaataaagc 1020241 gattttcatt aaaaaacctc ctcgcctttc attataaaag gatgttctca gtttgaacag 1020301 cgcgggaaag aatacctgta caaataaaca gaacgatggg aaacatattc atgaatcatg 1020361 gatacactta cgaattgaac cagctcccaa ttcacaatgg tgatgaatga caccccgatt 1020421 ccctcccttt ttttctagga tatgtggagc aggaaaaaag ggtgacaaaa taaagagagc 1020481 gcggaaaccg cgccctctat agccatatat tgaattgtta ttgaactctg ccgcccattt 1020541 gctgctgagc gaaagatact aaacgttttg tgatttctcc tccgacagaa ccgttagcgc 1020601 gagaagttgt gtccgctcca aggttaacgc cgaattcaga agcgatttca agtttcattt 1020661 gatcgatagc ctgagctgcg ccaggaacta gtaagtcatt tgaagagttt tggttagcca 1020721 tgtgtaaaat ctccttttta tttagtatgg ttgggttaac tggagttgca ccaatctgtg 1020781 aacccttctc gggtgtcact gccgcctcgg cgtaacccaa tgctttgccg gcttgttact 1020841 acgtattatg ttaaaatggc cggaaaatca tgcggagaat tgtgtggtaa atcttgagaa 1020901 ataaaaaaag cttagccgtt taggctaagc tagtcataaa tatgaaaaag catcagttca 1020961 tgtatctcgt ttgtaagagc aggctcgtca gcgcgggcgg gaaacaagtc tccccattca 1021021 atctcaccgc tcttatgata gatgccttca taatgggtcc ctttataata aaatgaaatt 1021081 ttccatccgg gcagcttttc ttttgggaac aaaggtttcc agctgaaatg agaaatcatt 1021141 acggccacgc tccttacatt tggtatcaat tgacctaaat aaaaacggct tatgttcatt 1021201 gtatcattgt ttcagaacat cattgaagag gcctaaatat gcagtttgtc ccagctttgg 1021261 ataaagataa gcccgcttta ttaaaaaagc ggacaggtta cgaaggccac aatgcttccg 1021321 gagatgtgat tgccttctca gataaatatg acgcgtattc aaaacttctt cgttttgtaa 1021381 gagaatcaac atgatgcaaa tttggatgag aaaaaatgct tcggcccggg cgcgaattcg 1021441 cttcaaacat ccatacttta ccgttctgat caatgccaaa atcgaaacca atctccccga 1021501 taaatccctc gatatgatca tgaaggacat ggcttgcagt cagtgccgct gcagaaagct 1021561 ttttaatgac ctcaactctt tcagcgggat catcgtatac ttccgcaagt gtctttacag 1021621 tgccgccgtt agaaagatgt gttgtaatgc tgttctttcc ggaaattttt acggcgattg 1021681 ctgtcactgt ccattttcct tttctgtttt tattggtatg gacacggaaa tccgctggtt 1021741 tgccttgaaa ttcgatgaga tcaacacctt gctgaatgag aaagtcggac gggttgtgat 1021801 gtttttgaaa ttctgcaagg aatgaggcgg catcggaata atcaattgat gtaaaagttt 1021861 tggcgtcatt cgtatgcttt accgtcaggc cgccatctgt tcttgtcagc tgataaatgc 1021921 cggtgccgag tgctccattt gccggtttga tatagacttt tttgtatgcg ccacagagct 1021981 catctatcag ctccacagac ggtgtcagct cggatctagg caaaaagggt gccgttcttg 1022041 gatctttttc gagcaattga tgaacgttcc atttattgaa aaacgtttta ttaaaccatg 1022101 ggatctgata ttcatcgatc agcctctttt ttgtatgttg caagagaagt gaatcttcaa 1022161 tttttcggtt cggcaaacgg tcataaacga cgttcggcaa tggaacgatt tttttctccc 1022221 agccgttttc cctgtaaagg aggccttcaa tcgtgccttc ctcccaattg atttggtgcg 1022281 cgccaaaaac gaagcagtag cccccggctt gctcgtgtaa cgtgacaagt ttagaaaaaa 1022341 agagggaacg atccttaaat gggcgttcaa gagatacagt aaaccctgcc gtaaagatgc 1022401 cgactaacgg cccgatatgc actgtatgat catgaatcag tatatctgcc ctgcttcggt 1022461 ggggaagcaa aagctcatga aacagatttt cagagagaag cacggtttgt tccagatgcc 1022521 gtctgtaagc aacgtggcat ctgacaacct tcgttccgaa tgcggcatgc aaaagtccgt 1022581 cttgcttcag cgaagagggc agaaacaggg tgttttcact ggttttgtct atgccgatca 1022641 aaaaccgttt aggattcacg cggaagaact cctttctggc tttgctcaga aaacagatat 1022701 tggcagcgtt ttaggggaca agtgtacagc tgttcttttt gctcgggaga gacacgcagg 1022761 attgacttcc tgcctggttt ggaattgata tctaaaatcc aaattctccc gtcctttgca 1022821 agacatatat caagaccgag ttcaaacaac ggcccatagc gctcgtcaag ataatacgga 1022881 accgattggg taattgaaaa cacatcatct agtaaaacca cttgctgttt tttcggtata 1022941 tcttcaaacc aggagtcaaa tgtcagcgca tcagatccgc ctgacaaatt ggccagcagc 1023001 ccgtgtttgt atccgcgtct tactgccttt ccgactgtat tccattcacc tgcttcgttt 1023061 ttttccataa acagacgaat atcacaaggg tattgttcct tatcttgaat gtttaagtaa 1023121 ggctgaagca aatattgatg ctgaagcact tttttgcacc atgttttaaa agaagtctgg 1023181 ttggaaaacg tttttgtctg cttatccttt ccgatgtgat aagtagcagt gatgtttttc 1023241 ttgcccagct tcaaaagaat cacgcctctg cctcccgcgc cgaatgccgg tttaaggatg 1023301 caggcttttt ctttggataa aaaggagtga atttgttcgt agcggctcac ctttatcgtt 1023361 tcgggaatat agggattgat tacagagtgc tgctgcaaat cgtgaaggac ggtccactta 1023421 tcgggaagac cccgcccgat aaattccgtt ttcggatatt ttttgagcca ctcaacgatt 1023481 ggttttgctt tttgggaatg tgaatccttg ccgtaaaaac agcgatcata aatataatct 1023541 ggaatcgcca tttcagtttc gttccatgtg ctgctggccg aatgatagac cgatgctttg 1023601 acacgcaaag tgtcaggtga aatatcaaat ggtgtaaacc ggatgaaacg tatgccgaat 1023661 tcgggtgctc ttttggccag ttctgcggaa taatccgctt catgctggcg ggataaggac 1023721 ataaaaccga gtgttatcat ggtgagactc ccccttttat tcaaaagctg ccggcgggtg 1023781 tccgcagctt tacactaaat acatgtaaga cgaacgcagc tgacggtatt ctactttaca 1023841 gaatacgatt ctccaccttg ccctattcca aaagaacaag ctgattttct aagaacagga 1023901 atttgtctcc tcgtttgcta agtgattgca tgagcctcta taatacgtat aggtacataa 1023961 tctatatgaa aaaagctgaa gcacagatgg aggaagatga ataggaatgg gtattgcagg 1024021 aacctttatt tttatgatcg tgatcggcgc tgccattgga gcggtgacca atcatttagc 1024081 aattcaaatg ctgtttaggc cgtataaagc gtactatttg tttgggaaac gagttccttt 1024141 tacgcccggg ctgattccaa gacggcgaga tgaacttgca aaacaaatgg gactgatggt 1024201 agtcaatcat ctcttaaccc ctgaaggcat taaaaagcgg ctcgtctctg atgcagccaa 1024261 aacgcaggct cttcgagtgg gggaacagct gattcaaaag ctgtcacttt ctgaagtgac 1024321 agtaaaagaa gcgcttgaaa aagccgggat gaagcgcccc gaaaaagctg ctgatgcatg 1024381 gatcagcagc tggaccgatg ataagctgca tgagcttttc cgccaatacg gggaccaatc 1024441 gttaaaagag ctggtgccta tagaggtgca ggaaaagctt gaggaaaaaa ttccgatgat 1024501 ttcaggatat atattgtcac ggagtgtccg ttattttgaa agtgatgaag gaaaaatccg 1024561 tcttggcaat atgattgatg actttttaaa agagcgcggc atgcttggaa gcatggtgca 1024621 attgtttctt ggcaattcaa gccttgcgga tcgcgtgctg ccggagctgc tgaaattctt 1024681 gcgcaatgag gaaacaaata aattgctttc tgatctctta aaaaacgaat ggggcaagct 1024741 gagggagtat acgtttaatg aagcagatga aaaatggaat gcaaaggcgc tcattttcag 1024801 tttgaaacga agagtgctgc aagcattttc gactgcccct ttcttcaaca atacgattgg 1024861 cacgcttacc gtccgctatg aatctgagct gacccagcaa atgctgccgg cactattaga 1024921 caaattgctt gaaggtattt cgtccaacct tgaaagtgtc ttaaaacggt tgcgtcttga 1024981 ggaaatcgtc aaggagcagg tggatcagtt cccggtggag cgtcttgaag aaatggtgct 1025041 gtccatttca aaaaaagaat ttaaaatgat tacctatttg gggggccttc tcggcggaat 1025101 tataggcgcg attcaagcat tgtttgtcat ccttttttaa gaagaaatgg tttttgatta 1025161 atgaaaggag ctccatagtc tgttatagtg gagtggtatg tcaaacggca atgatgaaag 1025221 gagctattta caatggctgt taatttttat gatgtagcgt atgatctgga aaatgcatta 1025281 cgcgggagcg aagaattcac ccgtttaaaa aacctttacg acgaagttaa cgcagatgaa 1025341 tcagcgaagc gcatgttcga aaacttccgt gatgtacagc ttagactcca gcaaaaacaa 1025401 atggcaggag aagagattac acaagaagaa gtgacgcagg ctcaaaaaac agttgcgctt 1025461 gtacagcagc acgaaaaaat ttctcagctg atggaagcgg agcagcgcat gagcatgctg 1025521 attggtgaat tgaacaaaat cattatgaag cctttagaag agctttacgg cagtgttgaa 1025581 ggctaataag caaaatccct tcttggataa gaagggattt tttattcact cagcaaactt 1025641 ggaaatccaa tgaatctttt acctctccat tgatgatgac tgataatgta tgaattcctt 1025701 tgtaatgctt tctggtggtt aaatccttaa aggattggat tcttgtgtat gacttcgttt 1025761 cgttttttcg tatatttgtt tctgttattt taaatacttt ctgatgacgc tggcctcttg 1025821 cttttacaaa atcaattgcg tactcaattc ttactttttg atccctgtct gaatgaatat 1025881 agaaagaaaa ttcaaggctt tcgccaataa ctatacgttt gggctggcat gttaaatcat 1025941 gtagttgtat cgaatcagca ttttcataac caaaaagcgc taaggcctgt ttatcaccct 1026001 tttttaataa ggtccgatag gcgtgtttga taatccagtc tgtatgggga tgtgttccgt 1026061 accattgatc tgcgactttt ctcagtaaat gaggatgcgt ttttgatata tcattaaggt 1026121 tgttggccac gctttttctt acatataaag actcgtcctg catcagcttc tcaaggatcg 1026181 gcaatacggg ggaagggtcc gatttcaaag ccggtatcga ttttccccat ggcaggcggg 1026241 gcctgctgcc ttcgctcgca agtcttctca cgtgttcatt tttatgctca gaccatgcaa 1026301 gcaattgtgc aatcatcttt tcttgatcta acagcaaaaa aggccttaca gcaaattctg 1026361 aggtcgaata ttgcgtaaag gattccaatg cctttattga ttcttcccaa tgcgctaacc 1026421 cgtactgttc cacataatct ggaaataaaa ttccgctgag tcctttaaaa tgaggggctg 1026481 tatcccgtaa aattgtgagc gcttcaacgt attgttttgg caaagtttcg tataaagaaa 1026541 ctgtcacgcg gcgcatccgc tcttttaaag tgagttcagg ccagtcctcc agccgtaatg 1026601 tatccaagaa tctgtttttg ttaaaatcag gataggatga ccttacatga tggatcaact 1026661 gagatatcag ttcttcatta tatatttctt ttaaatcagc catataaaca ccgctttttc 1026721 gtttattatt tatattgtat gggaatgtac gttctggatc aagtgtatag tcctaaaaat 1026781 taacaactga tcctaccacg gatatacaaa agttggttac tttttttagt taaaaaaacc 1026841 cttgtcatcg gaaaggaaaa ctgagataat aacattgaaa gcgcctacac ttacctattt 1026901 caaatggata cggtcgcata tcatgccgtt atatagaggg gataagcaac agagagtaag 1026961 tgttcggagc gcatcattgg tcaaacaagg ggttcctgat acatgatttt tcgtaaatcg 1027021 aaataacgat attagggaga atggctgctt cgatcgtatc ctatcaacaa gccatacata 1027081 aagtctgctg agccaggctt tttttgcttt aagaaaaggt tgttctaaac acagagacag 1027141 ggtcatatcc tatacacaag tacagtcatc aaggaggggg acatctctgt gtcaaaacaa 1027201 ttgcttgcct taaatataga tggagcgctg cttcggtcga acgggaagat tcatcaggca 1027261 acgaaagacg cgattgaata tgtaaagaaa aaagggattt acgtcacact tgtgaccaac 1027321 cgtcattttc gctcagcaca gaaaatagcg aaatcgctaa agcttgatgc caagctgatc 1027381 acccatagcg gggcatatat cgctgagaaa attgacgccc cgttttttga aaaaagaatt 1027441 tctgatgatc atacctttaa cattgttcaa gtgctggaga gctatcaatg caatattcgg 1027501 cttcttcacg aaaagtattc catcggaaac aagaaaaagg tgaattcgaa tttattaggg 1027561 aaagcactca ttcatccgtc tgacccgatc ttttatccag tccagttcgt tgaatcatta 1027621 agcgatctcc tcatggatga gccggtgagt gcacccgtca tcgaggtgta cacggagcac 1027681 gacattcagc atgacattac agaaacgatt acaaaagcct tccctgcggt ggacgtgatt 1027741 cgcgtaaacg atgagaaact gaatatcgtc ccgaagggtg tctcgaagga agcgggtttg 1027801 gccctcgtcg cttcagagct gggcctgagt atggatgatg tcgtggccat tgggcatcag 1027861 tatgacgatc tgccgatgat cgaacttgcc ggtcttgggg tagcgatggg gaatgccgtt 1027921 ccggaaatta agagaaaggc agattgggtt acaaggtcca atgacgagca aggtgtcgct 1027981 tatatgatga aggaatattt ccgaatgcag cagcgaaaag gatttcttga taagttccac 1028041 atgaaacgtg tgtaaaaaag ccgctcgcgc cctgacaggt gcggcggctt ttttgccgga 1028101 ttgattttag cagtttattt ctgtacacta aagaaagttt tgaatctgat aaattaggtg 1028161 atgaagttgc aaattaaaat agaaggcata catgatgacc gcctgcatcg gcctctgcaa 1028221 aatattgcaa atttgtttta tgaagagtgc gagcttgcgt atggcggaga ggagcccgca 1028281 gattttgtca tttctttagc gttgtcacaa acggatgagc atgtgacggt ttctggagaa 1028341 gtgaagggta ctggcataaa ggaacagcat acaaaattct tttctccaga catgactgaa 1028401 aaagaagctt ttaagcaagt gaaaaacaca atttcttatg tgtatctcaa tcttcttcag 1028461 gcgcatacgg gcattacgca gaagtgggga atcctcacag gaatccggcc cacaaagctg 1028521 cttcataaaa aactgcaaag cggaatgtcc aaggagcaag cgcatgctga gttgaaaaaa 1028581 gactatttaa ttcatgatga aaaaatcatg ctaatgcagg aaattgttga ccgtcagctg 1028641 gcggcagtgc cggatttgta ccgagtaaag gatgaagtca gcatttatat cggcattccg 1028701 ttctgcccga caaaatgcgc gtattgcaca ttccctgcgt acgctatcca aggacaggcg 1028761 ggcagagtcg gctcattcct atggggactg cattacgaaa tgcagaaaat cggtgaatgg 1028821 ctgaaggagc atgatgttaa ggttacaacc atttactttg gcggcgggac gccgacaagc 1028881 attacagcgg aggagatgga tctgctgtat gaagaaatgg tccgctcctt cccggatgtg 1028941 aaaaacattc gtgagattac ggtggaggcc ggtcgtcctg acacgattac agaagaaaaa 1029001 ctcgccgttt taaacaaata tgacattgat cggatcagca tcaatccgca atcctacgaa 1029061 aacgaaacgc taaaggcgat cgggcggcac catacggttg aagagaccat tgagaaatat 1029121 catctgtcac gccagcacgg catgaataat attaacatgg acttgattat tggtttgcct 1029181 ggggaaggcg tgaaggagtt caggcacagt ctttcagaaa cagaaaaact gatgccggaa 1029241 tcccttaccg ttcatactct ttcatttaaa cgggcgtcag aaatgacgag aaacaagcat 1029301 aagtacaaag ttgccggcag ggaagaggtt tctcaaatga tggaagacgc ggtagcctgg 1029361 acgaaagagc atgggtacgt gccttattat ttataccgcc agaaaaacat tcttggaaac 1029421 cttgaaaacg tcggatactc tttgccggga caagaaagca tctacaacat tatgattatg 1029481 gaagaggtgc agacgattat tggcatcggc tgcggcgctg ctagtaaatt tattgatcgg 1029541 gatacaggga aaattacgca ttttgcgaat ccgaaagatc cgaaatcgta caatgagcgc 1029601 ttcgagcact acacggacga aaaaatcaaa tatttagagc agatttttga aaaaacgaca 1029661 aagcagcact gattacagtg ctgctttttt tatccctgtt tttttgcggg ctgaacctca 1029721 ggcttccatt taaatacctt gttcagcaag cggtaaattc gttttgattc ctttgtgaca 1029781 agcggtccca aaatcgccag aatgaggaca tataatgcgg caaacggctt taatgtggcc 1029841 gacagtccgc cggctatccc gagattcgca acgataatcg aaaattctcc ccgcgatacg 1029901 atcgtcagcc cgatattcga tgaagcctta tgagaaagcc ctgcgcgtcg tcctgccacc 1029961 attccggcga taaaatttcc cagaatggtc aaaatcactg cacccaacgc aagccaaacc 1030021 gcttcaccaa gcgaaaacgg atcgatgctg aggccgaagc tgaaaaagaa catcgcaccg 1030081 aagaagtcgc gaaacggaac aacgaggtgt tcaatcctat cggaatgctc tgtttctgaa 1030141 aagaccaaac cgagcagcag cgcgccgatt gcttctgcta catgaatcgt ctctgaaaaa 1030201 ccggcgataa aaaagagtgc tgcgaaaatg acgataataa acacttcgtt tgagcgaatg 1030261 tccaacagtt tgttcaacag cggcgggagt tttcttgctg cgataaaaaa cagcagcata 1030321 taaccgaagg cgatcaaaat ggacaagagt gcactcccta cggatgtcgc atcacctagt 1030381 ataaggccgg aaacaacgga cagatatacg gcaaggaaaa tatcttcaaa catgatgatg 1030441 ccgagaatca attcggtttc cgggttggcg gttcttttta aatcaacgag cacttttgcg 1030501 acaatcgcac ttgacgagat tgtgatgacg cctgcgagga tgaggacttc cagaaaggaa 1030561 aatccggtga taaacccgta aagcagtccg aggctgaagt taatcaaaat ataaatcgtc 1030621 ccgccgaccg cgattgattt tcctgatttg attaacttcc cgacagagaa ttcgagtccg 1030681 agatagaaga ggaggaacag tacgcccatt cgcccgaaaa actcgatgat ttcactgctt 1030741 tgaataaatg ttagatcaat aatccccatt ttcggcgcgt gcggtccaac aagcattccc 1030801 agcacaatca gaaacggaat aatcgaaaat ttaattttat tggcgatcac actggcgatt 1030861 gccacaagca caagtgcagt tccgacttca aatacaagat ggtccatcgg ggctcacacg 1030921 ccctctccag aaagaaaatc gtgaatcagt ttcttcagat gctttctctc acctgagagg 1030981 acaagggtgt cattttcttc aataatcgaa tccgctccgg gatttaggag cttttcctgg 1031041 ttgtgtttga taatcgcaat aacagtgaca tcgtaattct ggcgaacatc aagctcaccg 1031101 agtgtgcgtc cgatcgattt ggcgcctttt tcgaccttaa accattcaat aataagatcg 1031161 ctgaaggcca tttcgatgga ctccagagct tgcggtttat agaccatgcc cccgagaata 1031221 gctgcaattt gccttgcttc agaatcatcc aatgaaatat ttgaaagaag ctcatccggg 1031281 tcccggtcat taaaccggta aatttccctt cttccgtcat catgaatgat aatcgtcatt 1031341 ttttcgtggc ttcttgtttc gatttcaaac tttttgccga tgcccggcag atcgttttct 1031401 ttaatattca atgaaaatcc ctccgaatgt agtgttggca gtatggggtg agttacaaat 1031461 aaaacttgag caaattatat tcggaggtaa ttagactggt atttgacagg gacggccaaa 1031521 gccttttcca gcctgtttat cagcggttcg tcaagtggtt tgacagagag ctgcctgaca 1031581 gactgcgcca gcgggctgta ctctttgatc agctcagccg ggtgcatgct gcccggcgat 1031641 ggcgtttttg ccgattgtgt ttcctgcgga tatgaagaca taggcacata gctgtcagtg 1031701 cttgcttcaa actgggaagg cagaaccacg tccgaagggg gaaagtacac cataaataaa 1031761 cttaacagaa aactgatcag caatttatcc atgttccttt cctcccttct catcaagata 1031821 tcccttcttt ttcactatat aaaactttat gtttccattc aaacaatatg catttttcag 1031881 tatctattga ccttgaaaaa taaaaaggtt tatttgggga tggcggggaa tgtataggag 1031941 aaagaaaaaa gtaagcgcat acatggaggt gcttttaatg gagtttgttc aatatgcatg 1032001 taatggggcc gttgcagaga ttatcctgaa tcggcctgat gcccatcacg ccctgaatga 1032061 acagatgctg tctgaattga aggaggcagt cgaaatggcg gctgcaagcg aggcgctcat 1032121 cgttctcctg agaggaagcg ggaaaggctt ttcggccggc ggtgatatca ggatgatgac 1032181 gtcagagcat gaccctgacc aatttaaacg gctgatggat acgattgagg ctgtcaccct 1032241 gaatttatat cagatgaaga aagtgacaat tgcagccatt catggtgctg ctgcgggact 1032301 gggcctgagt ttggcgcttt gtgcggacat tgtgctcgct gaaaaaaacg ccgttctcgc 1032361 gatgaatttt atcggcattg ggcttgttcc ggacggcgga ggacattatt tgctgaagaa 1032421 aagaatcggt gaagcaaaag cgaaaaaact gatttggagc ggaaaaaaac tatctgcctc 1032481 ggaagctgcc gatatggggc ttcttgatgg gacatttgcc ggagaccctg ccgaaggcgc 1032541 aagacccatt atcgaaaccc tgttggcctc ccctcttttg gcgatgatcg aaacgaaagg 1032601 tatttttcaa agcctccaaa ttgaagaact gaaaaaagtg ctatcccttg agcgcagcgc 1032661 ccaagagaga atgagaagga ccaaggatca ccaagaagga atccgtgcct ttttagaaaa 1032721 acgggagccg aagtttcaag cgtaacagat cagccggaaa gctgatcatc tgtgaaacaa 1032781 aatcagcttt ccggctgcat tgactaaacg atgagtatga ctatgaagct ctttttcttt 1032841 taagagggct tcaccatgcg tttttgccgc ttcttcatgt tctgcctcga attgctcgtt 1032901 taccagcgtg ttccccgaag gatcaaatac ggtaaggaaa taatcagcca tcaggtttct 1032961 cctccatttt aaggtttatc agtctttctt catttatatt ctaaaaagga aatcaaaatc 1033021 ctttattatg ctttatccaa aattagtata taatgggtca gggaaggagg agattcagtg 1033081 cttacaattg atcacgtaac gaagacattt ggagattata aagccgttga cggattggac 1033141 ttagatattc cggaacagca aatgttcggt ctattaggcg caaacggagc gggaaaaaca 1033201 acaacgtttc gcatgatcct aggattatta agcattacgg agggctcaat cagctggaag 1033261 ggccgtcctg tgaattatca tatcagcaac aaaatcggtt atttgccgga agagcggggc 1033321 ctttatccga aaatgaaggt aagggatcag ctcgtctatc ttgccagatt aaaagggatg 1033381 gagaagcgag aggctgtaaa agagctcggg acatggcttg aacgcttcaa tattacagat 1033441 tacgagaata agaaggtgga agagctttcg aaggggaatc agcagaaaat ccaattcatt 1033501 tcggcagttt tgcataagcc ggagctcctg attcttgatg aaccattcag cggcttggac 1033561 cctgtcaatg ttgagctgct aaaagaggcc gtgatctcgc tgaaaaacag cggtgtttct 1033621 attttatttt caagccatcg gatggaacat gtggaggagc tttgtgagaa cctttgcata 1033681 ttgcagaaag gaaaaccggt tgtacaaggc aagctgaagg agatcaagcg ttctttcggt 1033741 aaaaagaatg ttaccattca ctccgatgac gatctgcgct ttttgcagtc ccatgaaggc 1033801 attcttcaat ggaaggaaac ggcagacggc gtcaagctgc agattgccaa tgaagacatt 1033861 tctcaagaga tttttgcgat gctccaagga aaagggttta tcagaaagtt tgagcttgaa 1033921 gagccgtcac tgcatgatat ttttatagaa aaggtggggg ccgtctatga ataaattttg 1033981 gatcatgctt tctcatacat acaaaaataa gattatggca aaatccttta ttatttcgac 1034041 tgtcatcacg gtgctgcttg ttttagttgt aacgaatctg gagtcgatca tttctttgtt 1034101 tcaaggtgac gatgcgaaag aaaaaatcgc cgttgttgat gaaacaaacg aattatatcc 1034161 ggttttttct aagcagctga aagcggtgga tacagacggc gatcttgatg tgaagctgtc 1034221 gaagcaatcg gaggatgagg tcacaaagca agtcaaagat gaatcactcg atggcatgct 1034281 catcatcaaa cgagatgaaa aagggaccat ttcaggaaca tataaagcgt taacgatttc 1034341 tgatgaaagc acgtatcaaa cactgcagca ggcgctgacg caaaccaaaa cagctgtcgg 1034401 aacagcggag ctcggcgtgt cgcaggaaac gattagcagc ctttatgcgc ctgttactgt 1034461 ggggcagaag gcgctgaaag aaggggcaaa gtctgaggaa gagcttggcc agacggtagg 1034521 gcttgtttac attatgctgt tcgtcattta tttctcggtg attatgtatg ccagcatgat 1034581 agcgatggag gtcgcaaccg aaaaatcttc gcgagttatg gaaatcctga tctcaagtat 1034641 gccgccgatc cagcaaatgt ttgcaaagct gcttggtatc gggcttgtcg ggatcacaca 1034701 gcttgctatt attataggag ccggctctct gtcgcttaag ctgaaccaaa agagcgaaac 1034761 ggcttcatct gtcggcggat tccttaattt gaccgacgta tctgcaacca ctgtcatcta 1034821 tgctgtcatt ttctttttgc tcggatactt tttgtacgcg acacttgccg cgtttctcgg 1034881 cagtgtcgtc agcagaatag aggacgtgca gcaaacgatc acgccgatga cgcttttggt 1034941 tgtcgccggt tttatgatcg cgatgttcgg tttgaatgcg cctgacgcag gatttattac 1035001 ggtaacttcg tttattccgt tctttacgcc aatgattatg ttcctgcgcg tcggcatgct 1035061 tgatattccg ttctggcagg cggctgtcgg aatcggaatc acactgctca ccattgtcat 1035121 actggccgtt atcggcgcca gaatttataa aggcggtgta ttaatttacg gcaattcaag 1035181 cgcgttcaaa gcgatcaaac aagcgctacg tttagcgaaa aactgattgg aaaacagcct 1035241 ggggattctc aggctgtttc tttattgaca gaacgtgcat tcgcaagaat tcggtgctaa 1035301 aataagggta cttcatcctg gaaaggagca gaatgttgac tgatctaacc tttattcatg 1035361 cggcagatct tcatcttgac agcccgtttt acgggatatc gcatctgccg gagccgattt 1035421 ttgcccggat taaagaaagc acgtttgcaa gcgtgagaca tatgatagac gccgcagtga 1035481 gagagcacgt tgatttcatt ttgcttgcgg gagatctgtt tgatgaagcc aatcgaagct 1035541 taaaggctca gctctttttg aaaaaacagt ttgaaagact cagagagtgc ggaatttcgg 1035601 tatacgtcat ctttgggaat cacgatcatc ttggcgggga gtggacgccg attgaatggc 1035661 ctgagaatgt ccatattttt tcgtccgctg ttccagaaga aaaatcgttt tttaaagaag 1035721 gcaggcgcat agcaagcatt tacggcttca gctatcaagc cagagcattg atggaaaacc 1035781 aagccgcccg ctatcggaga tcaactgacg caccgtttca tatcggcatg ctccacggca 1035841 cgctgtcagg atctgaagga cacgatccgt attgcccgtt tacacatgac gacctcgtga 1035901 aaagcgggat ggattattgg gcgcttggcc atatacataa acgccaggtt ctatctgccg 1035961 agcatccggc agtcatttac ccgggaaaca cgcaagcacg ccatataaag gagacgggag 1036021 ataaaggcta ttatctcgtt catgtgacaa acggagatat atcttatgaa tttcagagag 1036081 cgcatgatgt cctgtgggaa aaagcggcgg ttgatgtgac ggaggcaaag aatatgacag 1036141 ccctcttcca aatggtggag gacacgtttt cgaagctgcg gaaaaagggg agccctgttt 1036201 gtgtaaggct tgttttacaa gggacggcgc cggaatggct gctggaggcg ccaaaaggca 1036261 ccttggatga gtttcttgaa gctcttcagg aacaagaagc ggaagaggaa cgtttcgttt 1036321 ggcctcttag attggacgat gagacagaaa acgaagcaaa cctaacaaac cttgatcctt 1036381 tttttggcgg tttatttgaa gacattgatc gcagcgatct gtcagacgtg ctggaagggc 1036441 ttgagcggca tccagtgtat agaaggcacg cggaccggtt tagccaagag gaggtaaagg 1036501 aaataaaaga gcaggcacag ataatattga aaagacagct taaggtgctt gatacatgag 1036561 gcggtgacag ctttgcgaat tatatcttta catatctacc aatacggaaa attttccaat 1036621 cggacctttg acttttccgc ctctcctgtc caagtcatct acggattaaa tgaggcagga 1036681 aaaacgacga tgatgtcatt cattgaaagc atgctgttcg gttttccgaa aacgaaaaag 1036741 tatgaaccga aaacaggcgg tgtctacggc ggtgttcttg aagctgaaca tcctgagtat 1036801 ggggtgctga agatcgaacg gacgaaaggg actgccgaaa aactaagcgt gtacacagaa 1036861 aagggcgaag taaagcaggg agatgtttta aagcagctgt tccagggcac agacaggtcg 1036921 ttgtacaaag ccatatattc gttcgacgta ttcgggctgc aggaaattca cgcctttaat 1036981 cgggacaaga taggggaatt tttgctcttt tccagcttgt ttggtgctga agccgtatca 1037041 aagcttgatt caaggctgac gaaggaaagc gaaaggctct ataaaccaaa tgggcgaaac 1037101 cctcaattga atcaggagct ggaaacgctt aagcagctgg cagttaagct aaaacaggct 1037161 gaagcagagg aagcgggcta tcatcagctt ctcgaggaaa aacgaacgct tgaagcccgc 1037221 cttgcagccg cggaaaccga attgaaagag acggcgggac atatccgaat gattgaggga 1037281 gcgattgagc gaaagccgct gctaaatgaa aaagcgacac tcgaacaggt gattgcagaa 1037341 tttccggaac acgcaggaca atttcctgct gacggactgc atcagctgga aaaatatgaa 1037401 tcccatcttc acccgaaatc agcacagctt gaggcgcttc gggtgaagat ggcggagttg 1037461 gacaaacaga ggcaaaagct tatccccgat aaagaactat tggcgaaaga aacgctgata 1037521 caagagcttt cggcagcgtt tcatatgtac caatcctggg gagaacagct ggcagccatt 1037581 caggcacagc tgcgccagac gtctgcgcag acagcggcag ggctggaaca gctcaataaa 1037641 acggatgaaa atgagctcct gaatatgaac acctcatatg attatgaatg gcagcttcag 1037701 caagcggtgc agcaatatgt acaggcaaga gacagaaaac ggcagcttga cgagacgttt 1037761 gaacttgccc ggcaagagct ggaagacgcg gaaaaggccg ttcgtgccgc ttcgtccgcg 1037821 attcttgaaa acagccaaag aaaagataaa gaagcagctc ttagagcata tgatgaaaca 1037881 caggggcagc accaagagca agcgaagctc agagaacagc taacgttttt tgaaagacag 1037941 caggctaaac agaaaaagac tgtcattgca gctggtatgt tgttcatcgt tctcttttct 1038001 ctgctgcagc aatggattcc cgccataagt ttcggcgctg cacttattgt gtattggctt 1038061 gtttcaggaa agtcgtcttc tcgaaacagc cgagagacaa gacagcccat gacggatatt 1038121 tcaccagcag aagctgaaat gcttagagaa gcgttatggg aggatgaccg caataagcag 1038181 caccttctca cacagcgtgc agcgctccag caaaaagagg cggcgtatga aagggtcatc 1038241 cagcagtttg aacagtggga agccgaaatg gcgccgtcct ttacacaggt tgagcgtttt 1038301 atgaatgagc tcggatttaa ggaagatcca tcatttttgc ttgatgcata cagcttaatg 1038361 aaggatgtta aaaaagaagt gaagaaaaag catgagctga ccatagaagc aggcaggctg 1038421 aaaaagcacc ggagaacatt cgaagaacgc gtcagtatgc ttcttcccgt gaatcagagt 1038481 caggatatct ccatttcgga cgcccttcac acattgcgga aaaacattga acgtgaaaaa 1038541 gaaattgaga agcaaaaaaa ggaaattgaa acagatattc attatacaaa ggaacagatg 1038601 cttgaacttg agcaagaaat acagtatttc cacgcacaga ttgaacagtt atttgccgcg 1038661 gctgctgcaa aagacagaga tgcgtttttt gccatagccg ccatcagcag gcaattgaag 1038721 gatacggaga acaagcttca tcacgtaaac gcacagcttc aaggcgggta cccggaggaa 1038781 cttgaactgg cggattccaa tacgctttct gaattgaaag ataagcaatt tgttgagaat 1038841 gaaagaaaag agcggctgac tgaggagatc gagcagctcc gcagccaaat cgcactgctc 1038901 tcagtcaaac aggaacaatt agaggcttcg ggaatggtct cagacctcaa gcttcaaacc 1038961 gaaatgcaaa aagaacgtgt gaaagaaacg gctaaaaaat gggcctccat acaaatggtc 1039021 aaacaggtga tcagaaacaa attggagcgg cataaaaaaa tcgagcttcc gcgccttctg 1039081 gagacggcag gagaattttt ccgtcctctg actgacggaa actaccaaac catttatttt 1039141 tccgaaacgg atgattcgat catggttatg catcgcgatg gcactgtcta tcatgcggaa 1039201 gagctgtcac aagggacgtg tgaacagctg tatacagcga tccgctttgc tttggccgtt 1039261 acgcgccagg gtgagtcaaa gcttccgttc cagcttgacg acagttttgt tcattttgat 1039321 caggaaaggc tgaaacgtgt attacatgtt ctgtatgatt tatctgaagg cggtaggcag 1039381 attttgtatt ttacatgcca tgagcacgta aaagatgcat ttcatagcag ccaaatcatc 1039441 catttggtgt cataaaagag gttctatagc tgaaaatcgg tatgtgatat actggtatta 1039501 tgtaagatac ggagggagct ttaatagaat ggctaaaggg attatgctac atgaggttgg 1039561 cgaacaggtg gaccagtatc tattgattaa atcctcgacg aaagggattg caagcaatgg 1039621 aaaaccgttt ctgacgctga tgctgcaaga ccagtcaggc gatattgaag cgaagctgtg 1039681 ggatgccaag caaagtgatg aagtgaccta tgcgccgcag acgattgtca aggtcgtcgg 1039741 cgatgttcac cattatcgcg gacgcaccca gctgaagcta agaaatatca gaccggtaag 1039801 cgagcaagaa aacgtcaata ttgatgattt tttagaaacc gcgccgattc cgaaaaatga 1039861 aatgatggat accatcactc aatatatatt tgaaatgaaa aatccgaata tccagcgaat 1039921 cacaaggttt ttggttaaaa aacacgaagc tgagtttatg gattatccgg cggctacgaa 1039981 aaaccaccat gagtttgtct caggtttggc gtatcatgtt gtctctatgc tgaacctggc 1040041 gaaagcaata gcagatttat atccttctct tgatcgtgat ctgctttacg ccggtgttat 1040101 cctgcatgat cttggaaaag tgaaggagct gtccggccct gtttccactt catatacggt 1040161 tgaaggcaat ttgctcggcc atatttccat catggtgaca gagctttcaa aagcggctga 1040221 ggagcttcaa atcgattctg aagaggtgtt aattcttcag catttgattt tgagtcacca 1040281 cggcaaagca gaatggggca gcccgaaacc gcctatggtg aaagaagcgg aaattcttca 1040341 ctatatagac aatctggatg caaaaatgaa tatgatggac agagcgcttg agcgcgtgaa 1040401 gccgggcgag tatactgaac gtgtatttgc actggaaaac cgttcctttt ataaaccgac 1040461 atttcataaa taacttaaaa aggactgatg ctgacatatt cagctcagtc ctttttgatg 1040521 cgtctttccc gcacataact cgtctcattc ccgcatatgg ttaagaataa agaatctatg 1040581 caaaggggga ggagcccgtg ttattttttc cgtggtgggt gtatctttgt attgtaggca 1040641 tcattttcag cgcatataaa cttgtggcgg cagccaaaga ggaagaaaaa gtagaccagg 1040701 cttttattga aaaagaagga cagatttata tggagaggat ggaaaaggag cgagaacgcc 1040761 gcagttctca gcagcatgaa gaagaaaatc aaaaccattc catcgcataa aaaaagctgt 1040821 gcggctcaat gagccgcaca gcttttttta ttatttagaa ttgcttgaag atgaagaagt 1040881 gctgttgctt gttgaagatg tattaaatgt gtctttcaga tctttatctt ttacttcgat 1040941 gtcagccttc ttcatgactt tttgaacagc ttcctgaaca gctgcgttgt catttaattt 1041001 ttgttcaagc acttcagatt tcagttcttt tttcatatca tcatatttgc cgcgttcttc 1041061 tgtcttttta atgatatggt agccgtattg cgttttgaca ggatcactga cttcacctgt 1041121 ttttaatttg aatgcagctt tgctgaatgt ttcgtccatt tggccttctt ttgcgaacca 1041181 gccaagatcc ccgccttttg aagcagagct gtctgttgag tattctttcg caaggtcttc 1041241 aaacttctcg ccttttttca gctttttctc tacttcttca gctgtctttt tatcagcaac 1041301 aaggatgtgg cttgcacgga ttttgccttt taagccttcc cagtactctt tgatatcggc 1041361 gtctgttact ttgatgttat ctttagccgc tttttgtgtc agcaattcat attttacttg 1041421 ttctttcagg taatctttgc catattgctt ttcgagggca gtatattgat cgccaagctg 1041481 cgttttgtat tctttcagct tgttgtcaat ttctttatcc gaaactttat acttcttgtc 1041541 caatactttt tcttgcacta gctgtgtcag tacgcttgcg ccagctgttt tcttcatgtt 1041601 tgtgtaaagc tcgccttttg tgacatcgcc tgcgtctgtt tttgcgataa cttctttgtc 1041661 gccgctgctg caagcactga gagcgaggat gcttgtagca gtgatagctg ctattgcgat 1041721 tttcttcatt gttttcaaac actcctaatc attccaaatt aaattaccta tgcgtatcat 1041781 aacatattgt ggctttctgt aaaaagattt taaataaagg gcattcgtct agtcaaactt 1041841 ttgctgatga catacttata tattgatcaa gaaaaggagg tatgtaacat gagcggagga 1041901 tactctaacg gattcgcgtt gctcgtagta ctgttcattt tgcttatcat cgtaggtgca 1041961 gcttacatct actaagcagc ccgaggatcg cttgcaacat aagcgatcct ttattttcac 1042021 tagcgcctaa tcgtttcaaa catgaattgc ataacatgta attggtaaat aaagcttatt 1042081 acaggaggtg ctatttaaga tgggtgaagt atttgcaggc ggattcgctt tattggttgt 1042141 gttatttatt ttattgatta tcatcggcgc ttcttggctg tactaatcaa cataaaaaag 1042201 catagctgct taatcagcag ctatgctttc tttcgtattt acactgtaaa ggagatctcc 1042261 acaaacgaag agatcagtaa aattaatata gatacattaa taaatcggaa taccttatct 1042321 tgccgctctt caggaatctc tctgacaagg cataatgtat tggtgagcct gtttatgaaa 1042381 tataaaataa acacggcagc cacgataaaa tagaataaaa tgatgggaga ttccccctct 1042441 ctctgaactg tcccatatta cattaccaaa tatttattaa aaaagataga atgcaaattg 1042501 aaaaatcgcc accagcacca gggtttgact acttttcaac aagaatatcc aagccgtcag 1042561 cttcctgatc aataaaagcg gttttcggtg cttttatcag cttgagagcc agcaggaaat 1042621 caggcagaca gtagccggcg tgaatgcccg agatcatgca aaaataatga gcgtgattcg 1042681 gaaatgccag tgctgcgtaa aacaataccg gtgtaatcag caagaacggg ctgacgagtg 1042741 aaatcagcat tgttgttttt ggtatacgtt tccatgtgcg catgcgcaat atgtaaaact 1042801 ttttttctat ttttcttttt ttgcagatga ttggcaggac atggatgact ttatgtacaa 1042861 ataaaataac gacgagcaaa ccgccgaata aagatacata ttcatcgctt aagcttgtgc 1042921 caggccgcag cagctcaaaa gctaaaaagg tagatataaa aaccaaaatc ataaaacata 1042981 cagcagttaa tattatgcga acggcgccat aatccttcat gagatttatg gtcttccagc 1043041 aattcatcaa agtcatcctt ccatacatct tgaatagaat ctcaaaataa tttactcctc 1043101 ccaagagaaa aaatcaatgc ttttttaaga aaaaatatca tccggcaggt atttttttga 1043161 aacaagcaaa caaactgcga aatatggggt tagaactttc ttctcagtga attatcagct 1043221 aaaataagat taaagataga aagaagtggt gtggatggat tcgatggatc atcgcattga 1043281 gcgattagaa tattacatac aattattagt gaaaacagta gatatggaca ggtacccctt 1043341 ctatgcgctt ctcattgata aagggctgag caaggaagaa ggggaagcgg ttatgaggat 1043401 atgcgacgaa ttgtcggaag agctggcaac acaaaaagcg caaggatttg taacctttga 1043461 taagctcctt gcgctttttg ccggacagct gaatgaaaaa ttagatgttc atgaaacaat 1043521 ttttgccctg tatgagcagg ggctttatca agagctgatg gaagtcttta tcgacatcat 1043581 gaagcatttt gattaactgt ttacaggttc gagctcttca gccggttcat ccgccgcact 1043641 gtcctttgct tttttcttca attttccgtt tacgctttca aagtcattgt caatattggt 1043701 gagtgacgtt tcgaaaattt ccataaaatc atcgccgtag atatggcgta tcatacacat 1043761 catttctgcc acttcaggaa attttccgaa taaatgatat aaaggctgtg accctttaaa 1043821 aacagcgttg cgtgtcggat caaattcctc aagcaagctc cagaatacct cggtaccttc 1043881 ctcagtcaat tggacatatg tgttccgttt atcattcagc cgtttggaga accttaaata 1043941 tccccgttct tccagctttt ttgaaaagtt gaatgcggtt gatacgtgca tgaccccgaa 1044001 tttcgcgatt tcagaaatgg aagctccatt caattgatac gcaatccata aaatatgatg 1044061 ctcattaata ttcaggtcat acggtttgag ccattgctgc caatccttct cgatcgattt 1044121 ccaaagagcc ttgctaagct gagccatttt ctgggtgaaa accagagctt ctttcacatc 1044181 atagggcggt tccactcgat tcattacgtc acctgcttct ctttttcttt ttctctatta 1044241 tgccaataaa ataaagatta ataaagatga aaatgtaaga attttttaat aaattcacaa 1044301 accattgcga cgaaagggtt tttcggccaa aaaaaatacg ggtccaattt tggcccgcat 1044361 ttttttcttt tgaataggat attagttttg taaggttttc tccagctgtc tgattttctc 1044421 ttcgatatcg gcaatttctt tttgcagatc ctgctggtga ggcttgatct cttcctgcca 1044481 ttttttaatt gatgtttgga gctcgccgcc cacgtcttta ataacatccg tgctttcttt 1044541 tgccgctttg atcagctggt cttttaatgc aagcccgtct gactttaagc gtttgattgt 1044601 ttcttcaaaa gaatcataat tggttttcat tttttcacgc agctgctttc ctgaggaagg 1044661 tgcagtaaga agaaccgctg ctcctccgat gatgccgcct acgaatagtc ctgttaatag 1044721 agaacgtccg ctcgccatta caatcacccc gtctttttct tcaaaatagg attcattcag 1044781 catttttcat ttttgttgaa agcctgaact tctatacata gcttgcttta ttttagcata 1044841 ttttttaagt gaaaaggagg gagaaggttg tctgtctttt tgattgtatt atcctgcatc 1044901 acccttgcct tcgcttcagg cgctgtttac tatatcaaac ttctcagcca ggctgcttct 1044961 tatccgccca agagggttat ccggcagaaa gcgcttgttt gttcaaccgg aaccgccttt 1045021 acactatgtc ttatcttttt cacaaaactc ctcgcttaaa acatgctgac atgctgcggg 1045081 cgctctgttc aaaaaaacct ctcccggaag cggaagaggt tttgtgtgac aattatttag 1045141 cagcttccat aaagcttgaa cgccttaaaa tggtttgcac aatcggataa ataatgatca 1045201 ttgagattgt attcagcaca gcggccggca gaacaacagc cgcgaacaat gcggcgaaac 1045261 cgcccggtaa accgacgatc aataaagctg acgatagaaa cacaattcct gataagatgg 1045321 tcccgatcac tgtcagcaca gcggctgcac ctgttttccg gctctttctg aacaagagaa 1045381 acagggagaa gaacagaaac gctgatacgg gtttatcaat gatgttaggg atctgtccgg 1045441 ctggaaacgc ggttgtaagc gcggaaatga ttccggtcac gatcccgatg acgagtacat 1045501 tttgcacccg cgggaacagc agaatgccca tgaacatcat gatcagcatc atatctggtt 1045561 tcatgccgcc taaaaagggc ggaataatgg aatgaagcgc tgcgccgatt gcggcaaaca 1045621 gagccataat gactaactct tttgttttca taactatgct ctcctctgct aagctttttg 1045681 ccctccaata atatgctcat catttattgc gaaggcttta cagaatgtgt tatgcaaaca 1045741 gtataccaaa cggacggttt gcatagccag actttttact cattttcctg ctggaatttc 1045801 ttcatgaacg cagctaattt ttcacagtct tcgagagaga ccgcgttata aatagaagcg 1045861 cggcagcctc ccaccgaacg gtgtccgcca aggccgatca tcttcgcatc ttttgctttc 1045921 tgaacgaatg ttttcgttaa ttcgtcatcc cgaagcgtga atgtgacatt catgcgtgag 1045981 cggctgtctt ttctggcatg tcctttatag aagccgttgc tttcatcaat acagctgtag 1046041 agaacctgcg ctttttgttc attgcgctgt tcaacagctt ccacaccgcc gttttccttg 1046101 agccattcca gaacgaggct cagcatataa atcgcaaatg tcggcggagt gttgtagagt 1046161 gaatccgctt tgacatgcgt ggaatatttc aagatttttg ggacgttcgc attttcattt 1046221 tgcagccagc tttttttcat gatgactaca gtcacgccgg aagggccgag gttcttttgg 1046281 gcgcctccgt agatcacatc aaatttggac acatcgattt ttctgcttaa aatatcgctg 1046341 gacatgtcgg ctacgagcgg aattggagaa ttcggaaact cctgccactg agtgccgaaa 1046401 attgtattgt tggatgtgat atgtaaatat gcgccgtctt ttacatccgt aaggtcaacc 1046461 tctggaatat aactgtaatt gtctgtttca cttgtagcgg tgatagacgt gttcccgaac 1046521 agtttcgttt ctgccagtgc tttttcagac caagcgccgg tcatcacaaa atgtgcggtt 1046581 ttttcaggtg ttaaaaagtt catcggaagc attgagaatt gaaggcttgc cccgccttga 1046641 agaaacaaga tatcgtaatc ttccggaatg cccatcagtt cgattaagag gcttttcgct 1046701 ttttggtgca ccgcttcata ctctttgctg cggtgggaaa gctccataac agacatgccg 1046761 gattcgttaa aatcaataaa ttctttctgt gctttttgca gaacttccag tggcagcgct 1046821 gcaggacctg cgttaaaatt cgttgtacgt tccattatga tctctccctg ttttccacgt 1046881 taatgtataa aataatacaa ttatcctatc acaaaaattc agttttttga taaaaaatta 1046941 gaattatcaa aagaaattga cggatgtttg cgaaatgttc acaaaataaa ataacctcat 1047001 cttatgatga ggccaggcgt tttgcgatag aggaagagat gttctgcaga tcctccggtt 1047061 tataatcatc agcatgcgtt ttccaaaccg ctccgaatcc atctcctttt ccgtagcgag 1047121 ggataatatg catatggtag tggaacacag attgtccagc tttttcgccg ttattgttca 1047181 gcgtatttaa gccgatcggt tcaaattcat cccggatagc gcgggcgatt tttggaacag 1047241 catggaaata ttgttttgct aattcatctg taaattcata tacattctca atatgtgttt 1047301 tcggaatgac aagcgtatgg ccttttgtca cttggctgat atcaagaaag gcaagtacat 1047361 gttcatcttc atacaccttc gctgatggaa tgtcgccggc aataatttta caaaagatac 1047421 aattctctgc acaatgcatg agggttcctc cttatgaaat tgtttagtat gtatacattc 1047481 atcgtaccac agaaatgcag aaaatagaaa acaggatgaa cggcgagcgt tcaccctgaa 1047541 tgcagaggaa gagcttatat gaagaaaatg tgttatgcct ttggtaagca cctcatttgt 1047601 caataaaatg aagacttgtt taatgcctaa cgattcctgc gataaacacc tcatttgaca 1047661 atttgcttca tacatgaaga attcatcaat tcagtgaaga gaaatggttt gagcattgga 1047721 catgtttatt ttctatccaa ctgtttctaa gacgtctttg acaaacacct catttttcag 1047781 ttgatatgct tttcctctac aacttttatg atgtccagaa ccctgtctct ttatgacagc 1047841 aaattcatca tttgttaaaa gggaattgtt tcaaatcagg ccttgttttt ggtactatga 1047901 agaaaaacac tataagggga gaaactatgt ctctgctatc ggtaaaagac ttgaccggcg 1047961 gatatacaag gaatccggtt ttaaaaaacg tatcattcac ccttgaaccg aatcaaattg 1048021 tcggcttaat cgggctgaat ggtgctggta aaagtacaac aatcagacac atcatcgggc 1048081 tgatggaccc gcataaaggt tcaatcgaat taaacggtaa aacgtttgct gaggatccgg 1048141 aaggctaccg ttcacaattt acctatatac ctgaaacacc tgttttatac gaagaattga 1048201 cgctgatgga gcatcttgaa ctaacagcca tggcatatgg actgtcaaaa gaaacgatgg 1048261 agaaaaggct gcctccgcta ctaaaggaat tccgaatgga aaagaggctg aagtggttcc 1048321 cggcccattt ttctaaagga atgaagcaga aggttatgat tatgtgcgca tttttggcag 1048381 agcctgcgct ctacattatt gatgagcctt ttctagggct tgatccgctt gccattaacg 1048441 cgctgcttga acggatgaat gaagcgaaaa aaggcggggc gagcgtgctg atgtcaacac 1048501 acattttggc aacggcagaa cgctattgcg attcgtttat tattttacat aacggcgagg 1048561 tgcgggcgcg cggcacgctg tcagagctca gagagcagtt tggaatgaag gacgcggcgc 1048621 tggacgattt gtatcttgag cttacaaagg aagacgctgg ccatgaataa tatgcttgat 1048681 atttggcagt cgcggctgca ggagcatatc aaagaaacaa gaacatacat gaaatatatg 1048741 ctcaacgatc acctcgtcat tgttttgatt ttttttctag cgggcgctgc aagctggtac 1048801 agcaaatgga tacgggacat tcccgctcac tttccgtcct tttgggtgat ggccgtgctg 1048861 ttttcgctcg tattgacaag ctcttatgtg cgaacgcttt tgaaggaggc tgaccttgtt 1048921 ttcttattgc ctcttgaagc aaaaatggag ccttacttga agcaggcgtt tgtctacagc 1048981 tatgtgtctc agctgtttcc gctgattgcg ctgagcatcg ttgcgatgcc gctttatttc 1049041 gcagtcactc cgggagcttc gctcgtatcg tatgccgcgg tctttgtcca actgttgctg 1049101 ctgaaagcgt ggaatcaggt aatggaatgg cgaacgactt tccaaaacga ccgcagcatg 1049161 aaacggatgg acgtcatcat tcgctttgcg gcgaatacac tcgttcttta ttttgttttc 1049221 caatctgttt atatgtatgc gcttctcgtc tatgtcatta tggctgttct ttatctgtat 1049281 atgtcttccg cagcaaaacg gaaaacattt aaatgggaga gccatattga gtccgaattg 1049341 agacgaaagc agcgtttcta tcggattgcc aacctgttta ctgatgtgcc gcatttgcga 1049401 aagcaagcca aacgcagagc ttatctcgac tttttgctgc ggcttgtgcc gtttgaacag 1049461 cgcaaaacat ttgcctatat gttcacccgc gcctttttgc gttcgagcga ttatttgggc 1049521 attcttgtca gattaacgat cgttttcgcg ctgatcatta tgtatgtctc agccagcccg 1049581 ctgattgccg cggttttgac tgtgtttgcc attttcatta cgggcattca gcttctgccg 1049641 ctcttcggtc actttgacca tctggcgctt caagagctgt accctgtgca aaaagaaaca 1049701 aagctgaaaa gctatttctc tctattaaaa actgcactta gtattcaagc gctgctgatg 1049761 tctgttgcat ctgcctatgc agccggcttg accggttttc tgtacgcgct gatcggttct 1049821 gccgttctga tttttgttgt tttgcctgct tatatgacga ccaggctgaa aaagcacgga 1049881 aagctgtgaa ctgaaaagag gtaatcaaat gacagataat cagctgctga tgcaggaagc 1049941 tttggaatgg aaaatgcatt ttttgcgaaa ggattccatg tttgaacgct tttcgaagcg 1050001 tgtccagacg aaggtgaatg aacggattcc tgaaaaaatc catacggtcg tcaccgagag 1050061 tgtgaaaaaa atggtagaag cgacaatggc cggctctaat atcatcacct ataaaaagga 1050121 tacaagtgca ctgtcgctca gtgaaaaaaa cgaattggcg aaaaaaacga ttgtttctta 1050181 tcaaaaagtg gcagctgctg agggagtcgg caccggagcg ggcggcattt ttttaagcat 1050241 tgctgatttt ccgctgctgc tttcaattaa gatgaagtgt ttatttacct tgtcttccat 1050301 ttacggcttt gatgtcaagg atgcacaaga aaggatattt ttgctgctcg tgtttcagct 1050361 tgcgttttcg agtgatgatg gccgtaagtc gcttttttct gtcatcgaaa attgggagac 1050421 ggagaaaaag agcatcgact ggagagtgtt ccagcaggaa tatcgcgatt atatcgacgt 1050481 cgtgaagctt tttcagcttt tgccgggcgt aggagcggca gtcggcggaa ttgccaatta 1050541 taagctgctt gctcagcttg gagaaacggc aagacatgtt tttcatctga ggatattaaa 1050601 ggaaacagcc ggagaataaa cactccggct gtttttttat agctgatgat aggtgatcgc 1050661 agcgccggca aggaccttgg ccgctgtcag catggctttt tcgttgatat caaatttcgg 1050721 atggtggtgg gaatagactc gctctggctg ttcgggagcg gcgcctgtaa agaaaaaagt 1050781 gcccttcacg ttttgtaagt aataagcaaa atcctcgccg cccatttgtg gttcaccgtc 1050841 aatgacctgc tgaacgccct cggtattctt tgcggtgctc accaagtggt tcgtttctgc 1050901 aggatggttc acaaccgctg gataaccctg ttcataggtg tactcatagg acgcgccgtg 1050961 catgctgcat attcctttta caaccgcttc aatttctttc tccagaatgt cccggacatt 1051021 ttcatcaaaa gaacgcgctg tgccgatgag tactgcttgg tctgcgatga cattaaacgg 1051081 attgtcggcg atgaaggagc ctgtcgaaat gacggcggat tgaatcggat tgactttgcg 1051141 gctgacaatg tgctgcaaag aggaaacgat ttgcgaaccg attaggacgg cgtctttagt 1051201 atcatgcgga tgagcgccgt ggccgccctt tccgaagact ttaatcgtaa atcggtctgc 1051261 cgccgccatt acggcgccgg ggcggcagag aatagttccg agcggctcag ttgcccaaag 1051321 atgagtgccg aatatcacat ccgtgttttc gagacatccg tcatcaatca ttggctttgc 1051381 gcctccagga taatattctt ctgcatgctg gtggatcatc acaaatgttc ccttcagttc 1051441 atgtctgttt tggtgaagga ccttggccac tgcgagaaga gctgcggtgt ggccgtcgtg 1051501 gccgcatgca tgcatgacac caggcacttt ggaggcgtaa gggacatctt tttcatcttg 1051561 aatggggaga gcgtcaaagt cggccctcaa agcgactgta gggccgggtt cgcttccttc 1051621 tatatttgct aaaacccctc taccgccaac gtttgtgcgg attgggactc ctaacgattc 1051681 ataataggaa gcaataaatg cggcggtttt ttcttcttga aatgagagct caggatacat 1051741 atgaaaatgg cgcctgatct caaccatttc ttcaaaacag ccgtcgagct gtttgtttat 1051801 ctctttctgc agtgtggata tggacaaagc cgcttccccc ttttctatgc ttttccatga 1051861 ttgtatagaa aaagtctgaa tatttcaact catgctgttt taaagcatca tcacagctgc 1051921 gagggttgtc accaaaaggc caatcgcgac gggaatgaag ttttttctgg caagctcaaa 1051981 aggatcaact ttgcaaatgg ccgcggcggg aatcaaagcc catgggacca gtgttcctcc 1052041 gcccacccag atggcagaga tttgtccgag cgcggtcaga atagcgggat cggcatggag 1052101 agcggacgaa aagagctttg cgatggagcc ggcgagagaa atgccagaaa atcctgagcc 1052161 gtcaaggcct gttatggctc cagcggcagt taatgcagtg gcggcaagct cctttgacat 1052221 aggcatcata tgggataaag caatgccaag atcgttgaca atgccgtggg aacctttagg 1052281 gagtgaagtg cccagtatgc tttcatagcc tgagtcgcca agataaaaga aagcggcaat 1052341 cgggatgacg gggccgaaaa ccttaaaacc gaacttaaat ccgtcaataa aatagccggt 1052401 gattttttca agccctttat gcttatacac gaaaaaatga acggtaaaga ggatacaaat 1052461 tgcagacccg ccaattaacg cggttgcatc atttccttgt aggttaaaca agagcatgca 1052521 ggcgatatct gcaagaaagg caagcggaat caaaaaagcc agtatggacc gcaggcgttt 1052581 tggcaagtac agcgagttgt cttgttcgcc ggaaagaacg ggggaaaaag aagtgggatg 1052641 ctcctgtttt ttgcgttcgc gctgaatcat gataaaggca gcagttgttg ttgtcacacc 1052701 cataatcagc acaagcggaa tactggccga gacgacatca ccgactggaa tgcctgctgc 1052761 atccgcagtc agctttggcg ccgcctgaat gacaaagtct cctgacaggg caaaaccgtg 1052821 tccgaataag ttcatggcca tggccgcggc aagaggcgtc aaaccggcac gtgcggctgc 1052881 ggggagcagg acggcgccga tcaaagcgac acccggagaa ggccagaaga atagagaaat 1052941 ggcgaacatc aggcctccaa tcagccaata ggcagtcaca ggccctctca caaggcttgc 1053001 aaagggagaa atcatcgctt catttatccc tgtttttgtt aacaaatcac tcattgaaac 1053061 gataaagcaa atgatgaaaa tcgtgggcag cagttcgccg gccgcataga taaagctgtg 1053121 gaataaactg ctgacagaag ctgaaagtga atggctggcc catagcgata tgataaaaat 1053181 gccgaataga gaaataaatg tcgtgtcttt tctcagcagc ataaatagga taattgcacc 1053241 gataaaaaac acatacagaa catggacagg caaaatcccg acttccatca tcgatcactc 1053301 cttccgctta cagattattc ataggcgggc ggaaggtgcc gggacagagg ggagggttat 1053361 gatggaagat gaacattgat ctgtttcagc tgctcaatca gatgatgcct taatcctcta 1053421 ttcgcttttt gcagatgttt tgggaagcat tcaggagaaa aaatgacgca cccttcagca 1053481 agccagtttt ttctataggc gatgatgctt tccgatggct ctatatgagt tatcctcgtg 1053541 ctgcatctcg tactcatcaa atccgaactg aaaaccgcag cacgggcaga tttcatgaga 1053601 atgattgcct tcatgatcat atggcggttc agccaatcct taaacccgca gactgggcaa 1053661 gtatgcttca ttttgctttc ctcccaataa aataagctgc cggacatgcc ggcagctatt 1053721 cgacagcgaa atatgtggtg acataggaag gccgggagaa gatcgacgtt gtgtcaattc 1053781 cggcagatgt atcgcgtttt ttgtgggctt ctttgtaaga accggactgc tgccagtctt 1053841 gaaaggcgct ttccgtttcc cacaaggtca gaatgacata ggtgtcactg tcaagcggac 1053901 ggagcactcg aattgcttca aagccaggct cgttttcgac ttttcccgct ctgtttttaa 1053961 atctgttttc aaacagcgga cgcccttcct gagtaacggc aatattgttc aatactgcaa 1054021 aaccgggatg tttgatctct ccgacttggt caatgacttc ataagcgtgt ggtgcctgga 1054081 aaacggtatc tccgtttgtt tcatgaatta aaatggcgtt ttcctgcccc tgcatcaaaa 1054141 ggatattttc tgagggatgc ttctgtacga tcgtttttaa aaaatcggct gtcccatatg 1054201 taatataaac cttcatatca gccacctcct gcttgctagt atatcaaaac aatggtataa 1054261 gtttctattg gcgagtgctt cgaacataat tccaaacaat ttttcccata ctacctttag 1054321 aaaggcgagg tgagttcatg tttaagataa agaaaaagaa actttttata cctatcatta 1054381 ttttagtgtt aactgctttt ctcgctttaa taggatatat ttcaattatt tttctcggcc 1054441 attatgtcat agatgaaaaa aagcttattc ttcatgcttc ttcaaaaatt gttgatcaaa 1054501 acggagatga ggttgcaagc ctgtatacag aaaatcgcga gccggtctcg atcaatgaga 1054561 ttcctaagca ggtcagagaa gcgtttatcg ctgttgagga taaaaggttc tatgagcatc 1054621 acggcattga tgcaaaatcc gtcggaaggg cagtgtaccg cgatatatta gcaggcggaa 1054681 aggtggaagg cggaagcacg atcacccagc agcttgccaa aaatattttt ctgacacatg 1054741 acaaaacatt tctaagaaaa acaaaagaag tgatcattgc gattaatctt gaacgggatt 1054801 acagcaagga caagctgctt gaaatgtatt taaaccagct ttacttcgga cacggggttt 1054861 acggcataca agcggcgtcc cactattatt ttaataaaga agtaaaagat ttgactgtat 1054921 ctgaaggcgc tgttttggcc gctattccga aggcgccttc tacgtactct ccaattttgc 1054981 accctgataa aaataaggag cggcgtgata caattctagg tatgatgaat gaccaaggct 1055041 atatcagtgc gaaagaggct gtcaccgcac agggccggac gcttggactg catgtgaaga 1055101 aacagtcgga aacaccttgg tttgacagct acattgacct tgtgatcaaa gaggcggaag 1055161 acaagtattc catttccgga gagcagcttc ttcaaggcgg atacacgatc aaggtgccgc 1055221 tcgattcgaa gctgcagaag acggcttacc aggtgatgaa agagggaagc tattatcccg 1055281 gaacagatca gaatgccgag ggaagcgcgg tctttattaa taacaagaca ggcggtgtag 1055341 aagcggccat cggcggaagg gattacacat ccaaaggata taaccgtgtc acagctgtcc 1055401 gccagccggg ttccacattt aagccgcttg ctgtatacgg accggcgatg caggaaaaga 1055461 aatttaagcc atattctcta ttgaaggatg agttgcagtc ctacggagat tatacgccga 1055521 aaaactacga cagccggtat gagggcgaag tcactatgtc tgacgccatt acgtacagca 1055581 aaaacgcgcc ggctgtctgg acgctgaatg agatcggcgt cgaaacaggg aaatcttatt 1055641 tgaaagcaaa cggcattgat atccctgatg aaggccttgc tcttgctcta ggcggcttgg 1055701 aaaaaggcgt ttcaccgctc cagcttgccg gcgcgtttca tacatttgcc gcgaatggaa 1055761 cgtatactga acccttcttt atctcgagca taatagatga agacggagaa acaatagccg 1055821 atcataaaga agaaggaaag cgggtattca gcaagcagac gtcttggaat atgacgagaa 1055881 tgctgcagca ggtagtcaaa aagggaacgg ccacgtccgg cacctatcac ggcgacctgg 1055941 cgggaaaaac aggttcaaca tcttatacag gcgtctccgg cgcgacaaag gacgcctggt 1056001 ttgcaggcta tacgccgaaa ataaccgggg cagtctggat gggctatgac aaaacggatc 1056061 aaaaccatta tttgaaagcc gggagctcat acccgacgcg gctgtttaag gatattttga 1056121 cacaggcagg agaaaccggt catgtgttca caaagcctaa aaacgttaaa gaactggaaa 1056181 gcccgattga gctgaagccg gtcaaaacac tcacagccga ttacacattt aaagcagcgg 1056241 ggctctttac tattgaatta aagtgggacg ctcaagagga tgatcgggcc gtatacagaa 1056301 tttatgtaaa caaggacggc gaggagacgc ttcttgattc ggttgaaggg aagggaagct 1056361 atgaaattcc ttatgccaac ttattttcgg gcgcgtctta taaaattgtg ccttataata 1056421 cacagacaaa aagagaaggg gaaggaaccg attacgttca gccaaaattg ttttcctctt 1056481 aatggaattc ggcgattttt tgaactttga gctacatttc tataccattt gcctaaaaca 1056541 aggtatagtg taataagtca agaaatacga acgtatggtt gccgtatgaa aggtggaaat 1056601 cagatgagta aacgagaaac gtttaacgag acgtttttaa aagctgcgcg gggagaaaaa 1056661 gcggatcaca cgcctgtgtg gtatatgagg caagcagggc gctcacagcc ggaataccgc 1056721 aagctgaagg aaaagtacgg attgtttgag atcacacatc agcccgaact ttgtgcgtat 1056781 gtcacaagac tgccggttga gcaatacgga gtcgatgctg caatccttta taaagatatc 1056841 atgacgccgc tgccgtcaat cggtgtggat gttgaaatca aaaacgggat cggtcctgtg 1056901 attgatcagc caatccggtc tctggcggac attgaaaaac tcggccagat tgatccggaa 1056961 caggacgtgc cgtacgtgct tgagacgatt aaactgcttg tcaatgagca gctgaacgtc 1057021 ccgctcatcg gtttctcagg tgcgcctttt acgcttgcaa gctatatgat cgaaggcggc 1057081 ccgtcgaaaa actacaataa aacaaaagcc ttcatgtaca gcatgccaga tgcatggaat 1057141 ctgctgatgt ccaagcttgc cgacatgatc atcgtgtacg tgaaagcgca gattgaggca 1057201 ggcgcaaaag cgattcaaat ctttgattcg tgggtcggcg cattgaatca ggcagattac 1057261 agaacataca tcaaacccgt gatgaaccgg atcttttcag agctcgcaaa ggagaatgtg 1057321 ccgctgatca tgtttggcgt tggcgcaagc catcttgcag gtgattggca tgaccttcct 1057381 ctcgatgttg tcgggcttga ctggagactc ggcattgatg aagccagatc aaaaggaatt 1057441 actaaaacag tgcagggcaa cctggacccg tccattttgc ttgcgccatg ggaagtcatt 1057501 gagcagaaaa cgaaggaaat acttgatcag ggtatggagt cagacggctt cattttcaat 1057561 cttggccatg gggtatttcc tgatgtcagt cccgaggttt tgaaaaaact gacagcattt 1057621 gtccatgaat attcacaaaa caaaaaaatg ggtcaatatt cctaagcata tcttttggta 1057681 tcttaatgat atcctgtcaa aatgtttgta tcagatcatt aaagagggtg taaacagtga 1057741 gtagaaagaa aatggggctt ctcgtgatgg cgtacggcac gccttataag gaagaagata 1057801 ttgaacgtta ttatacacat atcagaagag gcagaaagcc tgaacctgaa atgcttcaag 1057861 atttgaaaga cagatacgaa gcgattggcg gcatttcacc gcttgcccaa atcacagaac 1057921 agcaggcgca taatctggaa cagcacttga atgaaattca ggatgagatt acgtttaaag 1057981 cgtatatcgg actgaagcat atcgagccgt ttattgaaga cgccgtagca gagatgcata 1058041 aggatggcat tacagaagca gtcagcatcg tgctggcgcc gcatttctcc acgttcagcg 1058101 ttcagtccta caacaaacgc gccaaagaag aggctgaaaa actcggcggc ttaacgatta 1058161 cgtcagttga aagctggtac gatgaaccga agttcgtgac atattgggtt gaccgagtga 1058221 aggaaacata tgcgtcaatg cctgaggatg aaagagaaaa cgcaatgctc atcgtatccg 1058281 cacacagcct gccggaaaaa atcaaagaat ttggagaccc gtacccggac cagcttcatg 1058341 aatcggcgaa attaattgct gaaggcgcag gcgtttccga atatgctgtc ggctggcaaa 1058401 gtgaagggaa cacgcctgat ccttggctcg gacccgatgt tcaggattta acacgtgatt 1058461 tattcgaaca aaaaggctat caagcatttg tatatgttcc tgttgggttt gtcgcggatc 1058521 acttagaagt gctttatgat aatgattatg aatgcaaagt ggttactgac gatatcggcg 1058581 caagctatta ccggccggaa atgccaaatg ccaagcctga atttattgat gctttggcaa 1058641 cagtcgtatt aaaaaaatta ggacgttaaa gaaggcgatg aacatgagtg acggcaaaaa 1058701 acatgtagtc atcatcggcg gcggcattac cggtttagcc gccgccttct atatggaaaa 1058761 agaaatcaaa gaaaagaatc tgccgcttga gctgacactt gttgaggcaa gtccgagagt 1058821 cggcgggaaa atccagactg tcaagaaaga cggctatatc atcgaaagag ggccagactc 1058881 atttctggaa cgaaagaaaa gcgccccgca gcttgttaaa gacttaggtc ttgagcattt 1058941 gcttgtcaac aatgcgaccg ggcaatccta tgtgcttgta aaccgcaccc tgcatccaat 1059001 gccgaagggc gctgtaatgg ggataccgac aaaaattgcg ccgtttgttt ctacgggtct 1059061 gttttccttg tccgggaagg cgagagctgc tatggatttc atcctgcctg caagcaaaac 1059121 aaaggatgat cagtcattgg gagaattctt ccgcagacgt gtcggagatg aagtggtcga 1059181 gaacttaatc gagccgctac tatcagggat ctacgcaggc gacattgaca agctcagcct 1059241 gatgtcgaca tttccgcaat tttatcagac ggaacaaaag catagaagcc tgattctcgg 1059301 catgaaaaaa acaaggcctc aaggctcagg ccagcagctg acggcaaaaa aacaagggca 1059361 gttccaaact ctgtcaaccg gtttgcagac ccttgtagaa gagatcgaaa agcagttaaa 1059421 gctgacgaag gtgtataaag gcacaaaagt gaccaaactt agccatagcg gctcttgcta 1059481 ttcgctcgaa ctggataacg gcgtcacact tgatgctgat tcagtaattg tgactgctcc 1059541 gcataaagcg gctgcgggaa tgctttctga gcttcctgcc atttctcatt tgaaaaatat 1059601 gcactccaca tccgtggcaa acgtcgcttt aggtttccct gaaggctccg tccaaatgga 1059661 gcatgagggc acgggttttg tcatttcaag aaacagtgac tttgcgatca cagcctgtac 1059721 gtggacgaat aaaaaatggc cgcacgcagc gccggaaggc aaaacgctgc ttcgggcata 1059781 tgtcggaaaa gccggagacg aatccattgt cgatctatca gataatgaca ttatcaacat 1059841 tgtgttagaa gacttaaaga aagtcatgaa cataaacggc gagccggaaa tgacatgtgt 1059901 aacccgatgg catgaaagca tgccgcagta ccatgtcggc cataagcagc gtatcaagga 1059961 gctgcgtgaa gcacttgcat ctgcgtatcc gggtgtttat atgacaggcg cttctttcga 1060021 aggtgtcggc attcccgact gcattgatca aggaaaagct gccgtgtctg acgcgcttac 1060081 ctatttattc agctaaaacc tccgctttat cgcggaggtt tttttgatgt gcaatggcaa 1060141 tattgtgtaa aaaatgattg aattgaacag caggttatga tacatttgca tatgtactta 1060201 atgactaaaa tgttcaaacg gtcagtttcg aggtgaatac aatgtcaata gatcgaaaaa 1060261 agctcatttt ggaggcggct acaaagtctt tcacgcagtt cgggtataaa gcgacgacaa 1060321 tggatcttgt cgcaaaactt gcgaacgtgg ggaagggaac catttatact tttttcaaaa 1060381 acaaagaaga gctgtttgac gagattttca ctactttatt aaaggaaatg aagcaaaaag 1060441 cggatgaagc gatggagccg agccttccgt tccatgaaaa tgtgcacaga gcgctgtttg 1060501 ccattctgga gttcaggaaa acacatcagc tgacgattaa aattttccaa gagaatgccg 1060561 agattggtac aatggcagtt caggaagtga tccagaaaat ggagcgatcc atcctgtctt 1060621 atatcaaaag caagattgaa gacgggatca aaagcggcgc aatcaagccg tgcgaccctg 1060681 agctgacagc ctttgtgatg ctgaagcttt atatcgcgct catttttgac tgggaaaaac 1060741 aacacccccc gcttgataaa gagacaattg cgggactgct tgaattgtat gttgtcaaag 1060801 gattgtcagc gaactagata atcctttctc tttgcaagaa aatgaccatt ttttatgatg 1060861 agtcagtttt agaatggagg catcaggatg aacacaatac gaagtcagtg gaaagacatc 1060921 gtaacaagta aaaaattatt gattcccatc atcgccattt tgtttgtccc gcttatttac 1060981 agcggcgtat tcttaaaggc ttattgggac ccgtacggca cagttgacca gctgcctgtc 1061041 gttgtcgtca accaagacaa gggagcaacg tatgaaggag aaaaacttca aatcggtgat 1061101 gatctggtca aagaattaaa ggataataac aactttgatt ggcatttttc caatgatctc 1061161 gaccaatcgt taaaggactt attgaatcaa aaatattatt tagttgtcga gattcctgag 1061221 gatttttcta agaatgccag cactgtatta gacaaaaatc cgaaaaaatt ggatctgaaa 1061281 taccatacaa atgcaggttc taactatgta ggggcaacga tcggcgaaaa agcgattgat 1061341 aaactgaaag cctctgtttc aaaagaagtg accgagcaat atacgaaagt tatttttgat 1061401 aactttaaag atatcgcaaa aggtttgagc gacgcgagca gcggcgcgaa aaaaattgat 1061461 gacggcacaa aggatgcgaa aaacggaagc gcccagctga aagaaaatct ggcgaagctg 1061521 aaggaaagca ccgctaccat cagtgacaaa acagcgcagc ttgcagatgg agcggctcag 1061581 gtgacgagcg gcatccaatc acttgacagc tcgctcggta aattccagga cagcagcaac 1061641 cagatttatg ataaatctag tcagcttgca gcaggatcag gcgagctgac aagcaagatg 1061701 aatgaacttc ttgccggact tcaaaatgtg cagaagggta cgcctaatct tactaacggg 1061761 ttggatcagc tcaacagtaa agtccaagaa ggttctgaga aagcggcaaa agcggaaaag 1061821 atcattaatg cgctcgattt aacgaagctt gaaactgctg taaacaatct ggaaaagtca 1061881 gaaactgcga tgaaggaatt caaaaaacag ctgactgact ttgaaaacag tttgaaaaac 1061941 cgtgatcagg catttaaaaa tgtcatcaat tcgagtgact tcttaacagc ggagcaaaaa 1062001 agccagctga ttaattctgt tgagaaaaag cttccgcaag ttgatgcgcc tgattttgat 1062061 caaatattaa gccagctacc tacagctgat cagctgcctg acatcgcaac gataaaaagc 1062121 tctcttgaag acgtgaaagc gcaggtggcg caggtgaaag ccatgccgga agctacatct 1062181 aagctttata acggcgcaaa aacaatccaa gatgcgattg acagattaac tgagggagct 1062241 gataagatat acaacggttc tcagaagctg acagatggcc aaactaaact gacagcgggc 1062301 atcggtgaat ataataagca gttcgcaaaa gcaaaagcgg gctcagagca attggtgaca 1062361 ggaagcagcc aagtatccgg cggattgttt aagctgttag acgggtctaa acaggtccaa 1062421 agcggatcat caaaacttgc agacggatct gcatcacttg atacaggttt aggcaagcta 1062481 ttggacggca caggagagct gtctagtaag ctgaaggatg cggctgacca aacaggagat 1062541 atcgatgctg atgatcaaac atacggcatg tttgcggatc cggttaaaac caaagatgat 1062601 gccattcatt ccgttcctaa ctatggaaca gggctgacac cttatatcct gtcaatgggc 1062661 ttgtatgtcg gcggcatcat gctgacggtt gtcttcccgc tgaaggaagc gtcaggacgt 1062721 ccgagaaacg gttttgagtg gttcttcagc aaattcaatg tcatgatgct tgtaggaatc 1062781 attcaatcat tgattgtggc gacggttctt ctattgggaa ttggtcttga ggtagagagc 1062841 acgtggagat tttacgtgtt tacgatcatt acgagtctcg ctttcctggc gataattcaa 1062901 tttttggcta caacgatggg caacccgggg cgatttatcg cagtcattat tttagtgctg 1062961 cagctgggag cgagcggagg aaccttcccg ctggaattgc ttccgaattt ctatcaggtc 1063021 atccacggcg cattgccgat gacctacagc attaacggat tcagagcagt catttcaaac 1063081 ggtgactttg gctacatgtg gcagatggcc ggcgtcttaa tcggcattgc cctcgtcatg 1063141 attgcactaa gcattactta ctttacaatg ttaagccgga aggaagaaac atcagaagaa 1063201 cagccggctt cataaagaaa aagaacttgt ttccttggaa acaagttctt tttttgttac 1063261 atcccccatt taataagcaa tcctgtatag gttaatccgc cgccaaaccc gaaaagcaaa 1063321 acgatttgat cttttttcag cttcccggct ttcactgcga gatcgagcgc caaaacaatt 1063381 gaaaccgaag acgtgtttcc gtagtgctca acactagtga gcgttttttc aatcgggaac 1063441 ggtgtttttt cacaaattga ctcgatcatg cgcaagttgg cgctgtgagg aacaaaccaa 1063501 tcgagatcat cggagctgag tcctgcttta tgtaaaagcc gttcaaattc gccagggacg 1063561 gttcttgcgg cccatttata tacctcgcgt ccgttttgca ccatttttcc ggaaccgaca 1063621 agctgcacac cgtttatttc atttcgcagt ccggcacgat acaaaatatc gccgccgttc 1063681 ccgcttgttc cttgtacaga cgcaagaaat cccggcgtct cttcatctcg ttctactaac 1063741 agcgcacccg cggcatcgcc gaacagtacg catgtcgttc gatcggtata atcggttacc 1063801 tttgataacg tctctccggc gatgacgaga attttttgat gaaggccaga tgtgatcaat 1063861 ccatttgcca aatggaggcc gtatgtcagc ccggcgcatg tcgcattaat atccagcgcg 1063921 ccggtgcttt cccagccgaa atattcctgt acgcggcatg ccgtactcgg aaaggcgtaa 1063981 tcggatgtgg ttgtggcaac gaggatcata tcgacatcat caagcgttcc tttataacgg 1064041 ctcttgagat tcttcaccgc ttctatgcat aaatcagagg taaattgatg ttcatccgca 1064101 atccggcgtt ctctcattcc tgtgcgctga acgatccatt catcagaggt atcaacgatc 1064161 ttttctaaat ctgcattggt taaacgtctg ctcggcgcat aggtgccgat agctgtaatt 1064221 tttgcttttg acatatgaat cactccttat ggtcagatta taacactaga tattagtatc 1064281 tggtactaaa aagaaggttt ttttacaaaa aaagagaagt gtagatagga atctatgaaa 1064341 aagaaaaagg aggctgaaaa atggtcagtc aagaagcagt agtctttttg gcattatccg 1064401 gggctattgc gtttctgttg ccaatcgggc tgattgtatg gtttaagcga aagtatggtg 1064461 cctcgcttaa agtgtttttt attggcgctc tcacgttttt tgtcttcgct cagctgctgg 1064521 aaggcggcgt tcatgtttat gtactgcaag tgaatgaaat gacgaaagaa gcgatgcagc 1064581 atccattatg gtatggcatt tacggctgct tgatggccgg catttttgag gagtgcggaa 1064641 ggtatttgat gatgcgattt tttatgaagc gccatcatac ttgggcagat ggtctggctt 1064701 tcggggcagg ccatggcggg cttgaagcca tcctgattac aggcttgtcc tctatctcac 1064761 ttattgtata cgcatttgca atcaatagcg ggacgtttga acagcttttg gtcaatggcg 1064821 acgtcaaaca ggcgcttttg ccgatacagg agcagctgct gcatactcct tcgtatgaat 1064881 ggatgctggg cggaatagaa agaatcagtg ccattgccgt ccagattggt ctgtctctgc 1064941 ttgttttgta cgcggttaaa aaccgccggc cgctgttttt gctgtattct attcttttac 1065001 atgcactgtt taatgtcccg gcggttttat atcaaagagg aatcatagag catgctgcag 1065061 ctgttgaaat cattgttgct cttatagcgg ctttatcagt ttattggatt gtaaaagcaa 1065121 aaagggtgtt tcaataaaag gtccaagcag cagcaatgcc cgcttggaaa aatgtgaatg 1065181 gaaatattca ttaagcatgg gtcatcagaa tatttctgat tcagtcttta gcaatgacag 1065241 caagaatgtc tgtgtttttt acaagagaaa caatggtgtt tctttttctt cttctcgcaa 1065301 gggtcatggc attctttctt tttcttgcaa tggtcgtgga aatctttatc gaaccactcg 1065361 tcaaagaacc aaaaatcatc gaaccaatcg tgacaacgac atttctgttc atgtgaatga 1065421 cgacagcaca tagaaatccc tcctcttccc atgctctcta cagcatatga gagattgata 1065481 ggaaaagatt ggacgggtcc ctcgggaaaa gagtatattt taagtagaaa ataaaaggag 1065541 gaatgcccta tgacgtccgt acgtaaaacg atggagctca ttaaagaact tgtatcgatc 1065601 ccaagcccga caggaaatac atatgaggtg atcaattata ttgaaagcct tttaaaagaa 1065661 tggaaggtag aaacggttcg gaaccacaag ggcggcttaa ttgcaacgct tccaggacgc 1065721 gacacatccc ggcatcgcat gctgacagcg cacgttgaca ccctcggcgc tatggtgaag 1065781 gaaattaaag cggacggccg gctgaaaatc gacttaatcg gcgggttccg ctacaactcg 1065841 attgaggggg agtattgcca aattgaaacc gcctcgggaa aaatgtacac aggcacaatc 1065901 ttaatgcatc aaacgtctgt gcacgtatac aaagacgcgg gaaaggctga gcggaatcaa 1065961 gagaatatgg agatccgcct agatgaacct gttcactgcc ggaaagatac ggaggagctt 1066021 ggcattggcg tcggagactt tgtgtcgttt gatccacgtg tcgagatcac atcaagcgga 1066081 tttattaaat cgcgccattt ggatgacaaa gcaagcgtcg ccttattgct ccgcttaatt 1066141 catgaaattc aaacagaaga cattgagctg ccgtatacaa cccattttct tatttccaat 1066201 aatgaagaaa tcggttacgg cgggaattcg aatattcctc ctgaaacagt tgaatatttg 1066261 gcggttgata tgggcgctat cggtgacggg caggcgacgg atgaatattc agtatcaatc 1066321 tgtgtgaagg atgcgagcgg gccgtatcat tatcagctca gaaagcattt agttcaatta 1066381 gccgagaagc atcatattga ctataagctt gatatatatc cgtactacgg gtctgatgcg 1066441 tcagcagcga tcaaatccgg gcatgatatt gtgcatggcc tcatagggcc gggaattgac 1066501 gcttcccatg catttgaacg cacccataaa tcatctcttc gccataccgc taagcttctg 1066561 tattactatg tacagtcacc aatggtataa gggggaggac caatgaagat ttataagctg 1066621 aaaagcacat tcggttggga aggtgatgac gggttgggag aacagctgat tcagcagatc 1066681 cttgccggag aaaaaagcgc cacgtgcgcg ccgaaatcat tgtattcaaa agatgaattg 1066741 agggacgttt atcaaacagc gggtcagctt gttaccgttt atgataaaca tgacaatcca 1066801 agatgcaata taaaagtaac agatgtcttt gaaaccacct ttggtgcgcc tgatatgagg 1066861 ttagtcaaag gagagggcaa tggagaccga attgaggagt ttcaagagga tcatcggatg 1066921 gcatgggcgg aactgatcaa aagcggtgaa ctggagctga atgaggatac tgttttgatt 1066981 acagagttgt ttgtgcttgt taaagattaa aaaagcctgc ggggcaagaa ccccgcaggc 1067041 ttttcattaa ccagaaatgg ttgcgttttg ttctgttttc gattgggaca taacagtttc 1067101 tgctttcgca ggattaaaca tgccttccca tttagacatc acaacggcag caagcgcgtt 1067161 accagtcagg ttgacaactg tacgtgccat atccatgatg cggtctacgc cggcaataaa 1067221 ggcaagtcct tcagccggaa cgccgatggt gccaagcgtt gcaagcaaga caacaaaaga 1067281 agtaccaggt acggcagcca tccctttgga tgtcaccatt aagacgagca caagcgtaat 1067341 ttggtgccaa atcgtcaaat caatgccata tacctgtgct aaaaagagtg cggcaataga 1067401 ttgatagaga acggaaccgt ctaagttaaa cgtgtaaccg atcggaatga caaatgaaac 1067461 aatgcctttt ggacatccga ttttctccat tttttccatg atacgcggaa gaaccgtttc 1067521 agagctggac gtactgaacg ccagtaagat ttcgtccttc atgtaagcaa ggaacttgaa 1067581 gatgctgatg ccggcaattt ttgcgacaat cccgaaaata acaattaaga agaaagcaag 1067641 cgcgacataa accaatccga cgagctttcc gagagagata agagaaccga gtccgaattt 1067701 agacacagtc actccgataa gagcgaaaac gccgaatggc gccactttca tcacaaggtt 1067761 tacaacgtgg aacatggcat gggatacacc ttcaaaaaag gctaatacag gcttgcctct 1067821 ttcaccgatc gcggaaatac ccaatgcaaa tagtactgta aagcagatga tggctagaag 1067881 atccccttcg accaatgact ggaagaagtt tgtcggcaca atatggagga acgtttccgc 1067941 cactgattta ttactttgtt ctttttcagt ttcaacatat tgactgatgt ccgatttttg 1068001 agcttcgtgt atattaactc ctgtacccgg atggaagatg tttgcaaggg ctagtccgag 1068061 aataatggca aaagtcgtga tgatctcgaa gtacagaatc gttctgaagc ctaatttacc 1068121 gacttgcttt ccatttcctg caccggctac accgatgatt aagctggaga caacaatagg 1068181 aatcactatc attttgatta agcgtaaaaa gagatccccg attggctgca ggtaagtagg 1068241 caatgctggg ttgccatacc aaatgacgcc aacaatgaca cctagaataa gtccaacgaa 1068301 tatttgtgtg gctaatccaa acttaattct tttcatagat tacctcccaa aaaacaaagt 1068361 atcaacatat atcatgaata gacatatatt taatctcact attagatcaa attataatag 1068421 ataagaaatc aattcgtcta tagtaaatta tatttcgaaa ataaagaata ttcaatgaca 1068481 ttatgataat caccagaatt atctaaaaac aggtgagctt tgacctaacc tgactattat 1068541 ttcaaaatta agagatatgt gaaaaaataa gaaaatccca cgcgtaaggc gcgggatttt 1068601 cgctcattac aaatcgttta cttttataca gtcattgcag atattaccat aacactcatg 1068661 ctgctcttct atcttttttc cgcattccgc acactttttc gaaggcaggt ttctaaaaaa 1068721 ttctgtgatt ttccccagca taaccaatcc ctctttcccc tttgtagtga tttcattgta 1068781 atataacaga ttacaaaaat caataactgt tttgatacaa tgtttaaaac atgctttttt 1068841 caagaaaaat gggtatattg aaggaggacc aatttttttg aaaagatagg aggacattat 1068901 gaaagttaca gttatcggat gctatggcgg ttttccggcc gcaaatgaag cgacgtcagg 1068961 ctatttgttt cagtcaggtg attactctct gcttgttgat tgcggcagtg ccgtattgtc 1069021 taagctgttc ggatatgtgc cggcggaaaa gctggatgcg gtcgttctgt ctcattatca 1069081 ccatgaccat atcgctgata tcggaccgct gcaatttgcc aagcaagtcg gttcgtttct 1069141 cggcaaagga gagcatacgc ttccgattta cggacatgat gctgatatag aacagtttca 1069201 aaagcttaca tataaaacac atacaaaagg gatcgcctat cagccggatc agccgctgac 1069261 tgccggtccg tttacgatca cctttttaaa aacgattcac ccggtgacgt gctatgccat 1069321 gcggattact gacggcagcc acactgtcgt ttatactgct gattccagct atcaggattc 1069381 atttataccg ttttcgaaag atgctgattt attgatctca gaatgcaatt tttatgccga 1069441 tcaagacgga acaagtgcag gccatatgaa cagcctggaa gctgggcgca ttgcaaaaga 1069501 agccggagcg ggagaactgc tgctgacaca tttgccgcat tttggcgtgc atgacaacct 1069561 tcgcaaagaa gcgaaaaccg tttttaacgg agaagtgaat attgcgaaat caggttttgt 1069621 gtgggaagga taaaggagga gcaccatgtt atttatagac aatcaaaata tcaatgatcc 1069681 gcggatcaat cttgctatcg aggagtactg tgtaaagcat ttagaccctg aacagcaata 1069741 tttgctcttt tatgtgaatc aaccgtctat tatcattggg aaaaaccaaa atacaataga 1069801 agaaatcaat acaaaatatg ttgaggaaaa cgggattatc gtcgtccgcc gtttatcagg 1069861 cgggggcgct gtgtaccatg atctggggaa cttgaacttc agctttatta ccaaggatga 1069921 cggggacagc tttcataact ttaaaaaatt cactgagcca gtgattcagg cgttacatca 1069981 gcttggggtt gaagccgaat taagcggccg gaacgacatt gtagtagatg gccggaaaat 1070041 atccggaaac gctcagtttg caacgaaagg ccgtattttc agccacggca ccctcatgtt 1070101 tgattcagcc attgatcatg ttgtatcagc attaaaggtg aaaaaggata aaattgaatc 1070161 aaaaggcatc aaatcgatca gaagccgagt ggcaaacatc agtgagtttc tcgatgataa 1070221 aatgaccacc gaagaattcc gcagccattt gcttcgccat atttttaaca caaacgacgt 1070281 tggaaacgtg ccggagtata agctgacgga aaaagattgg gagaccattc atcaaatttc 1070341 gaaagagcgc tatcagaatt gggattggaa ctacggccgc tcaccaaaat ttaaccttaa 1070401 tcattcgaag cgttatccgg ttggatcgat cgatttgcac ctggaagtca agaaaggcaa 1070461 aatcgaggac tgcaaaatct tcggagattt cttcggtgtc ggtgatgtat ctgaaattga 1070521 aaacctgctg gtcggaaaac aatacgaacg cagcgtcatc gctgatgtgc tcgaaggtgt 1070581 gaatctcaag cattactttg ggaacattac gaaagaggat ttccttgatc tgatttacta 1070641 aggcaaaaca catcgtttga aagagcggtt gtgtttttga aataatggag gcaggaggga 1070701 ttcacatgaa agtgttttta atcggagcga acggacaaat cgggcaaaga ctcgtctctt 1070761 tattccaaga taatcctgat cattccatca gagcgatggt cagaaaagaa gaacagaaag 1070821 cgtctcttga agctgccggt gcagaagctg tgcttgcgaa tctggagggc agcccggaag 1070881 aaatcgccgc tgcggcaaaa ggttgtgacg cgatcatttt cacagccggt tccggcggca 1070941 gcacaggcta tgataaaacg ctgctggtgg atcttgatgg agcggcaaaa gccattgaag 1071001 ctgcggccat tgccggaatc aaacggttta ttatggtcag cgccctgcaa gcccataacc 1071061 gtgaaaattg gaatgaggca ctcaagcctt attatgtggc caagcattat gctgataaaa 1071121 ttctggaagc gagcggttta acctatacga ttatccgtcc gggaggcctt cgcaatgagc 1071181 ctggaacggg aactgtttca gcagcgaagg atctggagcg gggatttatt tcccgtgatg 1071241 acgttgcaaa aacggtcatt gcctctttag atgagaagaa tacggaaaat cgggcctttg 1071301 atctgacaga aggagatacg ccgattgccg aagcattgaa gaaactatga cagtactgac 1071361 actcagggct ttttgctctt gagtgttttt ttctgtttct ctataatgga gaagaaagct 1071421 tggcttcaat aatgaatgac tattcattca cttaaggggt gggagaatga atcttgtttc 1071481 aaaattggaa gaaacagcat ctgagaagcc cgacagcatc gcatgcaggt ttaaagatca 1071541 catgatgacg tatcaagagc tgaatgaata tattcagcga tttgcggacg gccttcagga 1071601 agccggtatg gagaaagggg accatttagc tttgctgctt ggcaattcgc ctgattttat 1071661 catcgcgttt tttggcgctt taaaagctgg gatcgtagtt gttcccatca atccgttgta 1071721 cacgccgaca gaaattggtt atatgctgac aaatggcgat gtaaaggcaa tcgtgggcgt 1071781 tagccagctt ttgccgcttt atgagagcat gcatgaatcg ctgccaaagg ttgagctcgt 1071841 cattttatgc cagacggggg aggccgagcc ggaagctgcg gacccagagg tcaggatgaa 1071901 aatgacaacg tttgcaaaaa tattgcggcc gacatctgcc gctaaacaaa accaagaacc 1071961 tgtacctgat gataccgcgg ttattttata tacgtcagga acgactggaa aaccgaaagg 1072021 cgcgatgctg acacatcaga atttgtacag caatgccaac gatgtcgcag gctatttggg 1072081 aatggatgag agggacaatg tggtctgcgc tcttcccatg tttcacgtgt tttgtttaac 1072141 cgtctgtatg aatgcaccgc tgatgagcgg cgcaactgta ttgattgagc ctcaattcag 1072201 tccggcatct gtttttaagc ttgttaagca gcagcaggcg accatttttg ccggtgtgcc 1072261 tacaatgtat aactacttgt ttcagcatga aaacggaaag aaagatgatt tttcttcgat 1072321 ccggctgtgc atttcgggag gcgcgtccat gccagtcgcg ttgctgacgg cgtttgaaga 1072381 aaaattcggt gttaccattt tggaaggcta cgggctctcg gaagcatcac ccgtcacgtg 1072441 ctttaacccg tttgacaggg gcagaaagcc gggctccatc gggacaagta tcttacatgt 1072501 cgaaaacaag gtcgtagatc cgctcggacg cgagctgccc gctcaccagg tcggcgaatt 1072561 gatcgtgaaa ggccccaatg tgatgaaggg ctattataaa atgccgatgg aaacagagca 1072621 tgcattaaaa gacgggtggc tttatacggg ggacttggca agacgggatg aggacggcta 1072681 tttttacatt gttgaccgga aaaaagacat gatcattgta ggaggataca atgtgtatcc 1072741 gcgggaggtg gaggaggtgc tgtacagcca tccggacgtc aaggaggcgg ttgtcatcgg 1072801 cgtgccggac ccccaaagcg gggaagcggt aaagggatat gtggtgccga aacgctctgg 1072861 ggtaacagag gaggacatca tgcagcactg cgaaaagcat ctggcaaaat acaagcggcc 1072921 tgccgccatt acgtttcttg acgatattcc gaaaaatgcg acggggaaaa tgctcagacg 1072981 ggcactgaga gatattttgc cccaataaaa tgaaaaagcg aagcggttag cttcgctttt 1073041 tcattttcaa tcctttgctt cttttttaat aatatttagc agcgcctttg tatcattttt 1073101 gcttaatttg tagtatgtgc catccttcaa aaaaacggct tgctggctgc cgtcaatcca 1073161 tagtctgaat gagtcatacc ggtctttatg aaacttgatt gtcccttcgt aatcaggggc 1073221 tgatgttttt tctgtcttca cctgttttcc ctgattcata atatccagca tatctttgac 1073281 gtgctgtctt ttttcaatct cgatatcttc ctggccgctt gaagacagtg tgatcaaatc 1073341 cgcgtctacc gattgataca catcgcctga tcggctgtaa agataaaaaa atgcgataaa 1073401 cacaagaccg attaccacga tggctgccac tatttttttc atttgcatca ctccaaacat 1073461 tgttagtttt cccagcgatc ggggtttcca tgcttaaaag ggtggaaaag tgcggaacac 1073521 agcttggttc taagaatttg aatttatgat tacaatagaa gtaacgggtt gatgtgagga 1073581 gtgaggcgtt atgcgcaagt ggattgcggc agcaggactt gcttacgtgc tgtacgggct 1073641 gtttttttat tggtattttt tcctgtcggg tgattccgca ataccggaag ccgtgaaagg 1073701 gacgcaggct gatccggctt ctttcatgaa gccgtctgag ttggcagtgg ccgagcagta 1073761 ttcgaatgtc aagaattttt tattttttat cggggtacca cttgattggt ttctgttttt 1073821 tgttctgctt gtcagcggtg tttcaaagaa aatcaagaaa tggatcgaag cggccgtgcc 1073881 ttttcggttt ttgcagaccg ttggttttgt gtttgtgctt tcgctgatta caacattggt 1073941 gacgctgcct ttagattgga taggctatca agtatcgctt gactataaca tttccacaca 1074001 gacaacggcc agctgggcta aggatcaggt tatcagcttt tggatcagct ttccaatctt 1074061 tacgctttgc gttctcgttt tttattggct gatcaaaagg catgaaaaaa aatggtggtt 1074121 atacgcctgg ctgttaacag tgccgttttc gctgtttctg ttttttattc agccggtcat 1074181 tatcgatcct ttatacaatg atttttatcc gctgaaaaac aaagagcttg aaagcaaaat 1074241 tttagagctg gcagatgaag ccaatattcc ggctgaccat gtatatgaag tgaacatgtc 1074301 agaaaaaaca aatgcgctga atgcctatgt tacaggaatt ggggccaata aacggattgt 1074361 attgtgggat acgacgctga acaaacttga cgattcagaa attctgttta ttatgggcca 1074421 cgaaatgggc cattatgtca tgaagcacgt ttacatcggt ctggctggct atttgctcgt 1074481 gtcgctcgcc ggattttatg tcattgataa gctttacaag cggacggttc gcctaacccg 1074541 cagcatgttt catttagaag ggcggcatga tcttgcggca cttccgctgt tattgctttt 1074601 gttttctgtt ttgagctttg cggttacgcc tttttctaat gctgtctcgc gttatcagga 1074661 gaataaggct gaccagtatg ggatcgagtt gacagagaac agagaagccg ctgttaaaac 1074721 gtttcaggat ttggccgtga cggggctgag ccaggttgat cctccggtgc ttgtgaagat 1074781 tttcagaggc agccatccgt cgatcatgga acggattcaa catgcggaga aagaagagaa 1074841 tgcgccggaa catcaggatg ctgacaaata aaaagaagca ggtatggagg aacctgcttc 1074901 tttttactat tattgtgcag ctgcttgtac gttgattaac ccttttccat agtagaaaga 1074961 gtttccaaga tatgttgcag tgctttctaa acgatcacgg acttgcgcgt ttgtccaagt 1075021 cgggtgctta gaaagaatta acgctgctgc tccggcaacg tgaggagtcg ccatggacgt 1075081 tccgttataa gcgccgtaag tgcctccagg aagtgtgctt tggatggaca cgccaggagc 1075141 catcacatca agctcagaac ctgcgctgga gaatgaagct ctttggttgc tgctgtttac 1075201 cgcacctact gcaatagtag aaggatattt tgcagggtag ccgactgtgc ttgtgcttcc 1075261 ggatgaacct tcgtttccgg ctgcggcagc aacgacgata ccgctggaaa cggctttgtc 1075321 aacgactgtt ttcagcgctg tagaaccagt aggtccgcca aggctcatgt tgataacatc 1075381 catattgttg gaaatggccc actcaatgcc gttaataatc cagctatatt ggccgcttcc 1075441 tgttgaatca agcactttta ctgcatataa tgatgcgctt ggcgctacgc ccagaacacc 1075501 gattgagtta ttaagagcgg caatcgtacc ggctacatgc gtaccgtgag aactgccgtc 1075561 ctggtatggg tttgtttcag aaggtacgaa gcttgctccg cctctgacgt ttaagtcagg 1075621 atgagaagag tcaattccgc tgtcgataac agctactttt acgttagagc ctgtgtagcc 1075681 ttgagagtga agagccggcg ctttaatttg agaaatgcca taaggaacag attgcgcata 1075741 ttcatgtgca atatgatctt cttccacata tgcaacgctc ggatcttttt tcaattcttt 1075801 tacagctttt tcatccaatg ttgctgcggc cgcgttaaca tacttaaatt gcttttgaac 1075861 ctttccgcct ttttcagaaa taacatcctt tttcttggcg gaactcatgg cactcattgt 1075921 ctgtttaaat ccgacaatgt atttcttttc tgtactgctt tttccggcag cctgcgcaga 1075981 catgttgctg aacgccatcg taaagattaa cgttaacgca aacaacaagc tgatccacaa 1076041 ttttttgctt ctcactcttt accctctcct tttaaaaaaa ttcagagtag acttacttaa 1076101 aagactattc tgtgaattta ttgtaataga tggaataata ttttagtaga cccatttttt 1076161 tgagatgatt ttatctctat ttaggtatat catctctcgc tatttccgta gagactcgaa 1076221 ataactattt tcatacagaa aagaacgaaa atagacatga gtaaatgttc attatgctga 1076281 aatgtcatgc ttttttaggt taaatgctcc tgagtcccgg caaattcctg tcgaaaaaat 1076341 tcgttcaaat gacctgcgtg tgcttccgtg agaacaatgg atattatcgt gatatttttt 1076401 caaagcatga tgataaaagt attctgaaaa ataaacttta cagaaaaggg atagaatgaa 1076461 aaaattattg agagggagga agaaataaga tgaacattcg ccaagcaaag acatcagatg 1076521 cggccgccat tgcgccgctg tttaaccaat atcgggaatt ttatagacag gcatccgatt 1076581 tgcaaggggc agaggctttt ttgaaagctc gtttggaaaa tcacgagtct gttattttga 1076641 tagcagaaga aaatggagaa ttcataggct ttacccagct ctatccaacg ttttcttctg 1076701 tgtcaatgaa aaggatatac atattaaatg acttatttgt cgttcctcat gcgcgtacaa 1076761 agggagccgg cggccggctg ctttctgccg caaaggatta tgcagggcaa aacggggcaa 1076821 aatgtttaac acttcagact gagcaccaca accggaaggc aagaagcttg tatgagcaaa 1076881 acggctatga agaggatacc ggatttgtcc attattgtct caatgtgccg gcgaagtgaa 1076941 aatggcggct tgatgatttg gttttttgaa cgttcttcgg ttacgatata aatgaaaagg 1077001 agtgtgccga atgtcaacgt tatttcaagc cttgcaggca gaaaaaaatg ccgatgatgt 1077061 ttcagtccat gtgaaaacca tatcaacaga ggatttgccg aaggatggtg tcctgattaa 1077121 agttgcttat tccggcatta attacaaaga tggtctggcc ggaaaagcag gaggcaatat 1077181 cgtcagagag tatccgctta ttttaggcat tgatgctgcg ggtacggtcg tctcttccaa 1077241 tgatccgcgt tttgcggagg gggatgaggt gatcgcgaca agctatgagc tcggtgtctc 1077301 acgtgatggc ggattaagtg aatacgcttc ggtgcctggt gactggctgg tgcctttgcc 1077361 acagaatctt tcgttaaaag aagcgatggt gtacggaacg gcgggattta ctgcggcgtt 1077421 atcagtgcat cggcttgaac agaacggtct gtctccggaa aaaggcagcg tgctagtcac 1077481 aggagcaacc ggcggtgtcg gcggaattgc ggtatcgatg ctgaacaagc ggggttatga 1077541 tgtggtggca agtaccggaa accgggaggc ggctgattat ttgaaacagc ttggtgcaag 1077601 cgaagtaatc agcagggaag atgtctatga cggaacgctt aaggcgctgt ccaagcagca 1077661 atggcaggga gcggttgatc cagtcggcgg aaaacagctt gcctcgcttt taagcaaaat 1077721 tcaatacggc ggatctgtcg cagtgagcgg cttaaccggc ggaggagaag ttccggcaac 1077781 cgtgtatcct tttattcttc gcggagtaag cctgctcgga atcgattcag tatattgtcc 1077841 gatggacgtc agagccgctg tttgggagcg catgtcttct gatctcaagc ctgatcagct 1077901 gctgaccatc gtggacaggg aagtatcatt ggaagaaacg ccgggtgcgt taaaagatat 1077961 tttgcaaaat cgcattcaag gaagagtgat tgtgaagctt taacaggatc agcttgcaga 1078021 gaatgttatt tttctgcaag cttttttgtg gacaggatga tcagctgctg aactgctgtg 1078081 tcgcgaaaca agattttcct gtaagccgaa ctttctcttc tcattttaaa aataattggt 1078141 gataatgatt ctcattccgt gttatactac tcttggacat cttaaccata gaaactacca 1078201 acaggagaga ctggaacata tgaaaaaaac actgattatt cttacagttt tacttctttc 1078261 tgtcttaacg gctgcttgct cgtcttcaag cggcaatcaa aacagtaaag aacataaagt 1078321 ggcggtaaca catgatttag ggaagacaaa tgtgcctgag catccgaagc gggttgttgt 1078381 tcttgagcta ggttttattg atacactgct tgatctcggc attacgcctg tcggggttgc 1078441 cgatgacaac aaagcgaagc agctgatcaa caaggatgtg ctgaagaaaa ttgacggcta 1078501 cacatctgtc ggcactcgct cacagccaag catggaaaaa atcgcttcat taaaacccga 1078561 tttaattatt gctgacacga cccggcataa gaaggtgtac gatcagctga aaaaaatagc 1078621 gccgacgatt gcacttaata atttaaatgc tgattatcag gatacaattg acgcttcgct 1078681 tacgattgca aaagcagtcg gcaaggagaa ggaaatggag aaaaagctga cggcgcatga 1078741 agaaaagctt agcgagacaa agcagaaaat cagcgcgaac agccagtccg tgcttttgat 1078801 cggaaataca aatgatacca ttatggccag ggatgaaaac ttctttacat cgagactttt 1078861 aacacaggtc ggctaccgat atgcaatcag tacgtcaggc aatagcgatt caagcaatgg 1078921 cggcgactct gtgaatatga aaatgacact ggagcagctg ctgaaaacag atccggatgt 1078981 gatcatcctg atgacaggaa aaacagatga cctcgacgcc gacggtaaac gcccgatcga 1079041 aaagaatgtc ctttggaaaa aactgaaggc agtgaaaaac gggcatgtat accacgtgga 1079101 tcgtgcggtg tggtctctgc gccgcagtgt agacggggcg aatgccattt tggacgagct 1079161 tcaaaaagag atgccggctg ctaagaaata aaagaaaaga caggcaaacg cctgtctttt 1079221 tcttatttga taaagccgga taagtggctg ttgatattat agtcttttat ccgccatttt 1079281 tcttctgcaa attcaatgtt gctgaggcag gcgttgacga gacgggtgct ttgaagctcc 1079341 gggtcaccgc cggatatttc tgtcagcagg gcgtgaattg ccgcaccgtg cgccacgatc 1079401 agcaccttct tgtttggata cgcctgattc acttttgcca aaccgcccat cagcctgtca 1079461 gtgagttctt ctaaggtttc catattcgga tagatgttat ctggatagcg ctttgtccgt 1079521 tcctccagcg gcatgccctc cgcgtcgccg taatcgcgtt ccttaaaatc atccatctcg 1079581 actatcggaa gatgcagata ttcattaata atttccgcgg ttcttttcgc tcttttcagc 1079641 gggctcgtca caataatatc ccaagaaaag tcctttacat attctccggt ttctcttgct 1079701 tggcgttcac ctgttgcgtt tagcgggata tcggttttgc cttggcattt ttgctgcagg 1079761 ttccaatcgg tttctccatg tcttactaaa caaacggctg tcataaaatc cccttcctga 1079821 ctttattcat atcgctatta tactaaatcg aaagcgtgtg tcctatgaaa aagcctatgc 1079881 aagaacttca aataataaag ccagtccgat tccgccgccg cttccgatgg ctgcaacagc 1079941 atattgacag tctggccgtc ttttcgcttc ataaaacaat ctggttacca gagctgcacc 1080001 tgatgcaccg tacggatggc caagagctaa ggcgccgccg cgcacattga tttttgaaaa 1080061 gggaatgccg agttcttgcg agcagacaca aattttgacg gcaaaggctt cattgatttc 1080121 aaataaatcg atatcatcag gtgttacatc gtgtgtatgt aagagctgac gaatcgcgac 1080181 aaccggtgcc gcgggcggaa agttggggtg aatgccgctg acagcgctgc cgataaaccg 1080241 aagcacaggc ttaagtccca gggctgctgc tttttcttct tccattacca aaagagcggc 1080301 tgctccgtct gctatgccac tgctgttggc tgctgtgact gttccggagc tggtgtcgaa 1080361 aaccggcttt gcacggggaa taatcgcttc tattggccgc gttttcaaaa atgcttcgtc 1080421 cgtctccaat tccccgagag caacaacttc ttcacggtaa aatccttcat catgcgcgtt 1080481 cctgctgcgt tgatggctga gaagcgcgta ctcatcctgc atgcttctgc tgatggaata 1080541 gcgtgcagcc gtatattctg ccgcaatgcc catgtctgga tcgccgatcg catctggaga 1080601 aaagcgagcc cgttctgaaa aaggggattg gctgctgctt tctgagccgc ccgcgatata 1080661 catcgtgccg gctcccgctt gaataaggct gcaggcatag cgcacagctt caaggccgga 1080721 gccgcactgt ctgtcaattg tcattccggg aaccgataaa ggcagtccgg cttgaagggc 1080781 tgacagtctg gccaggttgc cgcctctgcc agtagcgttt ccgagaatga cctcgtcaac 1080841 ttgatcctct agctttcggc tgagacagcg gatgatggga gccgccaaat cctccggcag 1080901 gaagggcttc agcagtccgt tttgatttcc aaagatcgtt cgttttgcat caacaataac 1080961 cgcattcatt tatactgtac actctcttcc agccattttt tcactctgga acgggcaatt 1081021 tttccgctgc tcgtttccgg caagctgtct gcaaacaccc attttttcgg aattttatag 1081081 gaggctaatt tctgtttaca ccaggctttc agtgttctgg cattagcgtt tccaagaatg 1081141 acagctacag cgatttctcc ccaatactcg tcgggaatgc caacgacagc cgcgctttca 1081201 acctctgggc aggcgagaag cacacgttca atttcttctg ggaaaatatt taatcctccg 1081261 tacacgatca tcccgttttc tcttcctgat atgtatagaa agccctcttc atcaacgtag 1081321 cccatatcat ctactgtcat ccattcatct ggtgtgctgc cgttcacata gccggaaaac 1081381 ctcatcgggc ttttgacaaa tatttttccg atttctcctg gctggcagcg ttctcctcca 1081441 gcgttgcgga tttcgatccg gacattatga aaagggcggc ccgctgaatg cggcttccgt 1081501 ttgctgtctt ccggtgaaga aaacgtcaca aaactaagct ctgatgtgcc gtaaaaatcg 1081561 tacagcttga gatgaggcca tgcagcggca agcttcttct tggattctgc cggccagtct 1081621 gcgccggatg aaatgatttt gacgggactg tcgggaaaac cctcaatcct tgcgagggcg 1081681 tctgtcatcg tcggtacggt atagagaaca ctgatggatt cacggcacag ccattccttc 1081741 gctttggcag gagaaaactt tttcagcaaa caaacggttc ctccgagaaa caaagtgctg 1081801 acagccccat ataggaagtg agaggacatt aacgctccgg gaatcagaac cttatcatct 1081861 gatgaaatcg aaaaatctgt ttctgtacag gtaaagctct ccatccatga gcggtgagat 1081921 cgcgtaaagg ccttcggttt tcctgtcgag cccgacgtaa atcccatata aaaagggtgc 1081981 tccggatcaa tggtaggcaa gggatcagcg gctgcctcag aaatatctgc catacagtta 1082041 tccagcaata caacaggtgt ctggctatct gtcagtttgt ttttgaaaaa ggctaaagta 1082101 accacaagat ccgcattgct tatggacagc cgctccttac attcagccgg gctccagcgt 1082161 gtgtcgatgg gaatggccgt acatccagcc gctgcggctc cggcaaacag ctgtaaaaac 1082221 gcgagactat ttgggagcag gatcgccaca cgattcggca tgctcggctg tgaccgcagc 1082281 caatttgcgg tttgagagac aagccgatcc caatcatggt acgtgatttg ctccgattca 1082341 gtctggatcg ctacacggcc gggcgatgtt tcggcagtag atgaataggt atgagtaatt 1082401 gtcatgtatt gtcatcctcc ttttgtaaac atcgtatcag aaagagacaa ggcttgagtg 1082461 atttttatcg ccagaaatgc agatacagcc gcttttatca aatcaccagg cacatatgca 1082521 aggctcatga aggcggcctg tgacaaatca atatgcatga taaaagcttg taccggtata 1082581 ccaagcagat aaataaagat gatgccgaat acgatatgag tgaaaaagag acgcaatact 1082641 gtcaccttcc gcagcctgtt agcggctaaa ctgatcagcc atgaagcgag gggataagca 1082701 atcaaaaagc ctgcgctcgg tccgaaaaac acaccaaaac cgcctcgtcc gccgggcaac 1082761 agcggcgctc cgaaggcgac gagcagcaaa aagacaagct ggcttaagaa agcagacttt 1082821 ggcctgagaa tgctgcctgc caacatgaca ccaagcgttt gcaatgtaat cggaacgggt 1082881 gtaaaggata agaagagagg gggcataaag ccgagcactg ccatcagcgc ggtgaaaatc 1082941 gcaatatgca tcatgtcgat taatttcagc atgtgaaatc ctccaaaaag taatcaaata 1083001 tggttataca ataaatgcag gtaattatta tgtcaactga tttttaattt aagtttacat 1083061 aatgaacgca aaaaaaccgg ccgtatggca gaccggtttt tgatggttat tcttctgtca 1083121 ggatgacaag cgaatcaacg gaagcggcca catgggaaac ggcgcggctg acttcctgaa 1083181 gccctccaag aaaggcttgc agatcgacgt cgattttgcc tgattgctct ttgctgattt 1083241 tcatgctgtg gacgatttca tcgaataagc ggttaatttg cgtcattttt tctttacttt 1083301 cgctgactag ctcattcacg tctttgatat gcttggatac aatgttgatt tgtgtattcg 1083361 tattgttcac aagctcagaa acagtagaga cggttttttt cgtatcctca gaaagcttcc 1083421 gcacttcatt tgccacgaca gcaaagcctt tgccgtgttc tccggcgcgg gcggattcaa 1083481 tagatgcatt gagcgagaga aggtttgttt gttcagctat gcctgtgacg atgccgaaga 1083541 ttttttcaat ttgctgcgcg atttcatcca gcttgaccat ttctttttcg atttggacaa 1083601 ggcttgtgtc aattttgttc atctgttttt gctggacttc tagctctttt tttccgccga 1083661 tcgacttttc ttcaacagtg ctggatgtta cagtgccggc tttggatgct tgagaaatgc 1083721 cttcagattt gtccacaagc tcttgaactg atctgcttgt ttctgaaaac agattggcaa 1083781 tcgatccaga ggtttcttga attttctgat gaagaaggtt tttcttttct tcttgttcat 1083841 cacgggtctg gttgtactcg ctttgaaacg cttcaaggac aagctgctgt tctaagttca 1083901 agatttttgt tgttgcttta atggctttta gcagttcttg ctgatttgta atggacgctt 1083961 cataaatgtc aatcattgac aaaaggagct cttgaaacgc acccatatac cattttggca 1084021 aaaggccgat tcttaaatgg atggaggcga ttcggttacg cttttcaata aattcatcat 1084081 cgataacgcc tgcaaacatt tcctgaatat gccgttttaa cgtttgtttt aagcggtcaa 1084141 ctgagctgtg atcattaatg atatccatca atgagctttc atggtcaagg tttttataaa 1084201 acgcatcgac gatatttacg atattttctt gaatgagtgg ctgaagctgc tctaacacat 1084261 aaagctcagc atctcccaac ctgaccattt tgagctgttt tttgacatct gcatgtttgt 1084321 ttgtgagctg aatgcggttt ttttgttgtc cgtttgaatc tgaaaagtaa gctgtttctt 1084381 gttttctgtc ttttttaaat aacaatacaa tgatccccct tgggaaaaat ataattttta 1084441 ctttttggct ttttaagcct ttttcttttt tatcggccaa gggaaacatg aatgaagctg 1084501 cagatgaaaa atatttgaaa aaacgttcat taaaatgaac ggtttaatcg agatctattt 1084561 gttttaatgg tttaatggcc ggaccctcta caacttcgcc agatggctta aagcgtgatc 1084621 cgtggcacgg acaatcccac gtatgctcac tgtcgttcca ctcgacctcg cagcctaaat 1084681 gggtacaagt cgtatcaacg agatggaggc agcctgtctc atcacgaaat gctcccgctc 1084741 gcctgccgtt tatggtgacg gctttccctt ctcctggcga aatgtcttca aattggacat 1084801 caggcttttc aagctttcct tttatcaaat gcttggcgac atctgcattg taggaaatca 1084861 ctttctgcaa cccgggattc agatggaaac gggacggcgt gaaaatgctt tcgtatgggt 1084921 tttctttttt ctccacaagg tctgacaata aagtggctgc gactgctgag gacgtcatgc 1084981 cccatttttt gaacccggtc gctactagaa tattgtcctc attttccgac atcggcccga 1085041 taaacgggat tttgtcgatc gtcactagat cttgggtgga ccaataatat ggaatgcttt 1085101 cgatgccgat ggtgctttcg gccagttgtc tcagtgtttc ataatgtgta gacatggctt 1085161 ttccctggcc tgttttatgg cttactccgc tgaagagaat cagcttttca ccgtttacaa 1085221 ccgtatagcg gagcgccact gacggctgat cgatactcaa atacatgccc tcgggatact 1085281 cgatcttcgg cttgatggca aggacataag atctgtcgga gtacattctc gcagcatata 1085341 atccgcctcc gtcataaaaa gggaagtggg aacagcatat gataaagcgg ctcttaatgg 1085401 cgtgccggct ttttgttacc acttcgggcc tttcgccttt tttgatatca agcgcaacgg 1085461 tctcttcata aattcggccg cctttttgaa caatttgctc cagaagcgct tttaagtatt 1085521 gaagcggatg aaattgagct tgattcttca tgacaagcgc cagcttagaa cctaagggaa 1085581 ttggaagatc cttgataagg tctctttcaa ttccgagctt tgtgtatgcc tcatgctcgg 1085641 tgtggatttt ttgaacagcg ttttcatttg ccgtataaag atatgcgtct tgctcgatcc 1085701 attcacaatc aatttgatgt tcatccacaa tgccttttat gtaatcaatt gcgttttggt 1085761 ttgcttcata ataaagcctc gcatggttta atccgaaatg gcggataaat tcgtcgtata 1085821 tcatgtcatg ctgtgcggta actttagcag ttgtatgcgc agtggttccg ttaagaacct 1085881 gatttgcttc aatcaaaacg acacggaagc ctctcttcgt aagttcatat gccgttgtga 1085941 ttcccgtaat cccgcctccg ataatggtga cgtcacattc agtgtcctct tgaagcgcag 1086001 gaaaagaagg caggtcagtt gatgttttcc agtatgtttc aggtgcttcc tttgcaaaat 1086061 gttgattagc caagccgtta tacctccaat cagatttatt cttaattttt ccatattcta 1086121 tcttttcata cataggaagc aggcattgtt cataacataa taaggttgaa aaggagtgat 1086181 ttcattggcg aatcaaaaaa agaaaacatt accgcctcag caccagaacc agcagcctgg 1086241 ttttgaatat ctgatggacc cgcgtccggt ttttgataag ccgaagaaag cgaaaaaatt 1086301 agagggcaaa accgctatta ttactggagg agacagcggg attggacgcg ctgtctcggt 1086361 gttattcgca aaagaagggg ctaatgtggt cattgtgtat ttgaatgaac atcaggacgc 1086421 cgaggaaaca aagcagtatg tagaaaagga aggggtaaaa tgcctgctga ttgcaggaga 1086481 tgtcggggat gaagcgtttt gcaatgatgt ggtcgggcag gcaagccaag tgtttccatc 1086541 cattgatata ttggttaaca atgcagctga gcagcatgtc cagcccagca ttgaaaaaat 1086601 caccagccac cagctgatca gaaccttcca aacaaacatt ttttccatgt tttacttaac 1086661 aaaggcagtg ctgcctcatt taaaaaaagg gagctctatt attaataccg cttcaattac 1086721 cgcctataaa ggcaataaaa cgctgatcga ttattcagcg acaaaaggcg cgatcgttac 1086781 gtttacaagg tccctttccc agtcgcttgt tcagcagggc atacgggtca atgcagtggc 1086841 accgggtccc atttggacac cgcttatccc ggccagcttt gccgcaaaag acgtggaagt 1086901 gtttggttca gacgtgccga tggaacgccc ggggcagccg gtcgaagtgg cgccaagcta 1086961 tctatacctt gccagcgacg attccacata cgtcacaggg cagacgattc acgtcaatgg 1087021 cggaacaatt gtgaacggat aataaaaagc caatccttga aggattggct tattcgctct 1087081 gcttgagcgc tgcatattct ttagagagcg taagaaacgc atctttatct ttttcgtcca 1087141 aggctttgtt aatttggtcc gtcagcatgg caagccgacg gttatacaag gattcatcga 1087201 gcaccatttg aatgtaaata tccgtcattg tgacatcgaa ttcttttgtt ttttgcgtgt 1087261 tgcgggactt catgagctca gtgtacgatt ttttctcttt cataaagaat ccccccaatg 1087321 ccttttttat agtatatgga taacggtcga aaaaatcaat aaatttttat aatttttaga 1087381 caactaatac ttggcaatct atcgacatat cctgcaaaat gccgtaaacc ggcaagtctt 1087441 atgaaagtaa aatcggttta ttactagtca tttagtacca ttaaatatca ttaaaagatg 1087501 attttatctt aaatgttaaa aaaacctgtc gttttacaaa aacagatgat agattattag 1087561 tataaatttt gcagaaaaag gatggaggcc ataatatgag tcagaaaaca gacgcacctt 1087621 tagaatcgta tgaagtgaac ggcgcaacaa ttgccgtgct gccagaagaa atagacggca 1087681 aaatctgttc caaaattatt gaaaaagatt gcgtgtttta tgtaaacatg aagccgctgc 1087741 aaattgtcga cagaagctgc cgattttttg gatcaagcta tgcgggaaga aaagcaggaa 1087801 cttatgaagt gacaaaaatt tcacacaagc cgccgatcat ggtggaccct tcgaaccaaa 1087861 tctttttatt ccctacactt tcttcgacaa gaccccaatg cggctggatt tcccatgtgc 1087921 atgtaaaaga attcaaagcg actgaattcg acgatacgga agtgacgttt tccaatggga 1087981 aaacgatgga gctgccgatc tcttataatt cgttcgagaa ccaggtatac cgaacagcgt 1088041 ggctcagaac caaattccaa gacagaatcg accaccgcgt gccgaaaaga caggaattta 1088101 tgctgtaccc gaaagaagag cggacgaaga tgatttatga ttttattttg cgtgagctcg 1088161 gggaacggta ttagaaaaat aggaaggagc tgaccgaaca gggcagctcc tttcataaag 1088221 ctatgccgtc ggaattcctc cggtgatgcc atatacctga gatgtcacat agcttgaatt 1088281 ctctgaagct agaaatacat aaacatcggc caattccact ggctgcccag cgcgatttaa 1088341 tggagctggc ggcgtgcctt gtccgaattt cgggatgttt tccgtcggct gtccgccgga 1088401 aatttgcagc ggtgtccaaa ttggtccggg cgcaactgaa tttactctga tgcctttgga 1088461 agcaagctgt tttcccagtc cgacggtaaa gccgataatg gcgtttttcg ttgctgcgta 1088521 atctaacagc atcgggcttg gattatagcc ttcaactgag gtagttgtga taattgaagc 1088581 tccctccggc aaatacggaa gcgccgcttt tacaacccag taaagggaaa agacgttcac 1088641 ttcaaatgtt ttatagattt gttcagtagg cagatcttcg atgttttcga ccgcttgctg 1088701 tttgcctgca acgagcgcta gcacatcaag tccgccgagt tcgtgatgcg actgtttgac 1088761 tagatcttgg caaaaggatt cgtcgctcaa gtctccgggg atcagcactg cttttcggcc 1088821 ttctgcttca atcagctctt ttacctcttc agcatctggc tgttcctcgg gcaagtagtt 1088881 aatagccaca tcggcacctt ctctggcgta agcaattgcg gcagcgcggc cgataccgga 1088941 atcgccgccc gtgacaagcg cttttcgacc cgttagttta cctgatcctt tgtagctttt 1089001 ttctccgcaa tcagggacag gcttcatgtt cttttgcagg cctggcggtt cttgatattg 1089061 ttcgggaaat tcatcatgaa aaaatgcttt tataggattc gtaagatttg aatcagacat 1089121 cagcaacgct ccttttctgt ttggtgtaca ttcgtatgtg tacccctgag cataagcaga 1089181 aaaacatgtt ttggcagttt gaatagtgaa ggaaaaagaa aacaagaaaa aacaaagcct 1089241 tcttccatat ttatcttgtc aaataagact atatgaatta tgataaattc gagctataaa 1089301 tcaactaaat attgggtgtt gggagagtga atcgtcatga aaaaagcggc ggcggttttg 1089361 ctgtcactcg gtctcgtttt cggtttttca tacggagctg gccatgtggc ggaagccaaa 1089421 acaaaggtga aggtctataa gaactgcaag gagctaaaca aagtatacaa aggcggagtg 1089481 gcccgcacat cgaaggtgaa aaacaaaggc ggaaaaacga agtacaagcc ttacgtttct 1089541 aaggcacttt acgatgccaa taaaaacaaa gaccgcgata aagatcttat cgcctgtgaa 1089601 cggtaaataa gaaaaagcaa tctggtgtcc agattgcttt ttttatgctt aggccgcctg 1089661 atcggccgca gcgcttttcg ccttccttgt cataaggctg actgccatca tgaccgtgat 1089721 attcaaaagc agggcgacga tgccgacatt caagtctttt gcggcttgcg gcagagccgg 1089781 aaataaagtg ccgatcgtcg tttccgtcat tgtaatataa gtaactgctc cgacacctgc 1089841 aataatgccg gcgaaagctc cttgctttgt caccatatta tgcttgagca ggctgaacaa 1089901 aagggcgggg aatagctgtg tgacaaggct gtagcccatc aaaagcagcg taacgatggt 1089961 attcccgcct ttgaaggtaa aatacaccga aatcagcgca atcaccggca ctaaaaactt 1090021 agcaagcgcc gatacttgct gttctgtcgt gcggggcgcg attaccttgt acacattttt 1090081 tgcaaacagt gtggaggcgg acattaagat catagaccct ggcacaagtg ctgtcagcag 1090141 tccggcagca ccgataattc cgacaaacca agggtcaaat gcttgcagag acagtctcaa 1090201 aagcgacaaa tccccgtctg cgccattcag atctggaact tgcaggatag ccgcaaagcc 1090261 gacgaaaagg acgaagagca ggaccagctg gtacaaaggc atgatgatgg cgtttttacg 1090321 aaacactttt gggttttcgg ctgaatacga agcggaaaac gtgtgaggcc acatgtaaaa 1090381 accaagcgct gtcaagagta cggttgaact gaaccaggcc acactttgtc ccgattcggg 1090441 gagcgtaaga aagccaggct ttgccgtttc aatctgctga aacatgtctt gaaatccgcc 1090501 gtagtaatga attggcaaat acacacctaa aaacagaacg acaaccagaa tcatgatgtc 1090561 cttcacaacc gatatccagg cagacccgtg aatgcctgaa accataacat aaaccgtgat 1090621 ggaaacagcg ccgatccaga tggcagcggt cggggtgatt ttgccgtacg aggtttccga 1090681 tacaatcagc ccgaggcctt tcagctgcag tacaagatag ggaatgagtg cggcgatgcc 1090741 gaccagtgaa acgagaatgc caagcagcgg actgttgtat ttttttgtga aaaaatcaga 1090801 ctgcgacatc agtttatgct gtttcgcgta cgtccaaact gctggaagaa gccagtaaga 1090861 aaggatgtag gccagacatc cgtaggcgat gatataaaag gctggaccgc cttttccgta 1090921 ggcccagccg ctgccgccga gaaacgtaaa agtagtataa atttcgcctg ccatcaaaag 1090981 gaagacgaaa acagttccga agccgcgccc tccgaccgtc cactgctcca ggttcatgtc 1091041 ttttcctttt tgggcgcgta taccgagaaa aatactcaag agcaggacac cgaagatgat 1091101 gatgagagct gcattcattc tgcttcctcc tttttatttt ccttgtcgag gacatacaca 1091161 atcgccatca gcgcagaggt caaaagagcc cacatcacaa tataggcaag aataaacggc 1091221 atgccgaaca catagggggt caccttattt gcaaaaggga tgccgagtaa gattccgata 1091281 aagggtaaag cggcaagaac gtgaatcagt ttcatagaat cctccttcta tttaggattg 1091341 aggtgtacaa gcctaagcgt actgaaaatg atgtcgcaga tatcgcagca catgtcattt 1091401 tttggagtga aaggctgtgg ttcgaattat aaataaattt attttgtttg tatagtgtga 1091461 attgtctgaa attaatgctc tgaatcgccc gaagagggaa cgggcagtat gattcaaaag 1091521 gctcagagtc tgtctggggc aaatagatag tatgttaata attcgctgac ctgctcacgg 1091581 attcgcggat taaaatagcg atggttttct tcataaccgt cgatgacaaa tgtatagagt 1091641 gtaaaggcct catcgcgttc cgtctcgcgg attgcaattt ttcttttcct cagttctttt 1091701 ctgacctcca tcaaatcctt ttgtgctatt tttaatgatt cgctgataag ctgtttataa 1091761 ggatgcttca attttaatgt gctttcttca attccggcga gatcacggtt aaaaatcgta 1091821 atggccatgg gcaaaaagag agcccgttca attaaatcgt atatttcctc ctgcagattt 1091881 ggcatattga ctccttcttt ctaagggaac gtttgttcta tttgtattct atatcggctg 1091941 gtgaaatgtt tcaagacaga aaaaatcacc aaaacttttt agttttctgc tgataatgtg 1092001 tagaataagg atagacaaac ccggtaagga gtataaatgt tggagcattt tttatcctat 1092061 ttgacacaag aacatttaac tgaattattt caaagctata gggctttcgg tccgctcatt 1092121 gctgtgctgc tgcctttaat tgaagcattt ctcccgtttt tgccgctgat cgtgtttgtg 1092181 gtggcgaata cgaactcgtt tggcttgtgg gaaggattca tcctatcctg ggcgggatca 1092241 actgctggtt ccattctcgt ctttttgatt gtccgtcaat acggacagag aaaattgctt 1092301 ggatttatcc gcagtcatcc gtctgtcaga aagctgatgt tatgggtgga aagacacggc 1092361 ttcggtccca tgtttcttct gctttgtttt ccatttacac cgtcagccgc ggtgaatgtt 1092421 gttgccggtt tgtcaaggat cggaacgcgg ccgtttattt tggcggcagc ctcggggaag 1092481 cttgtcatga tttttatgat cagcttcatc ggatatgatc tgcacgcgct gattacacag 1092541 ccgattcgaa cggtcatcgc cgtattggtg atcactgtct tatggtatgt cggcaaaaag 1092601 gtggagcggt atctgcatgt aagagccagt cagcgtgagc atgatggagg gagacagtaa 1092661 catgaaaaaa cggttttggt ttcttgccgg tgtagtgtcc gttgttctcg ccattcaggt 1092721 taaaaatgct gtctttattg attacaaggt agaaggcgtc agtatgaacc cgaccttcca 1092781 ggaaggaaac gaattgttgg tcaataaatt ttcgcatcga tttaaaacca tccatcgttt 1092841 tgacatcgtc ctttttaaag gccctgatca taaagtgctg attaaacggg taatcggctt 1092901 gcccggtgaa acgatcaaat ataaagatga tcagctgtat gtgaacggaa agcaggttgc 1092961 tgagccattt ttgaagcatt tgaaatctgt ttctgccggc agccatgtaa cgggtgattt 1093021 ttctttgaaa gatgtgacgg gaacaagcaa ggtgccgaaa ggaaaatatt ttgtcgttgg 1093081 agataatcgc atatacagct tcgacagccg gcattttggt ccgataagag aaaaaaatat 1093141 tgtcggtgtg atttctgatg ccgaataaaa agacgctaat tgaagaggcg tctttttgta 1093201 tgccgtttgg aaaaatgtgt tgaagaaaaa tttgtaagga gctataatca aaattgttac 1093261 ctgtgtaaca aaatttatat atttttttga ctggagggcc gtttttattg gtttttgttc 1093321 gtttttcatg aaacaaaagg agtggtgaat gatgatgaaa tatgaagcag tgattatagg 1093381 aggagggccg gttggattta tgctggcttc tgagcttgca atagccggag tgggaacatg 1093441 tgtgattgaa cggcttgaaa aacctgttcc gcattccaag gcgttgacgc tgcacccccg 1093501 aacgctggag cttcttgaga tgagagggat tttagagcgg ttcgtatcca agggaagcaa 1093561 gatacctacc ggacattttt caatgctgga tacccgtctg gatttttcag gcttggatac 1093621 gagctgtcct tacacgcttt tgctcccgca gtccaaaaca gaaaagcttc ttgaagatca 1093681 tgcacgaagc ctgggaacag aggtgtttcg gggtgccgag gcgctggcgg ttacgcaaaa 1093741 cggggaagcg gtccaaacaa tttttaagga tcgggacggc agtgtacgga cgatcacaag 1093801 caagtttgcc gttggggcag atggcgccgg gagtaccgtc cggaaacagg cgaaaattga 1093861 gtttccggga acagacagca ctgtcaccgc tgcgcttggg gatgtggtgc tcctttctcc 1093921 gccgccgtca ggtgtgctgt ccctttgcac aaaagagggc ggtgttatga ttgttccgtt 1093981 atctccagac cgataccgtg tcgttgtgat cagcccttat cgcacacaaa cgccgaaaga 1094041 tgtgcctgtg actgaggaag agctgaaagc tgacctcctg cgaatttgcg gaactgactt 1094101 cggtttaacc gacccttcgt ggatgtcgcg gtttgggaac gccgcgcgcc aagcgaaacg 1094161 gtatcgggac ggcagaatct ttcttgcggg tgatgccgcg catattcatt ttccggcggg 1094221 cgggcaagga ctgaatgtcg gccttcagga tgcaatgaac ctcgggtgga aactggcggc 1094281 ggccatcaaa ggctctgcgc cttcttggct tttggacagc taccatgatg agcggcatcc 1094341 ggcagcggaa gggctcctca gaaacacgga ggcacagaca aagctgatcg atttcactca 1094401 agcaggcctc catttgcgaa gcatgatgtc ggagctgctg gccttccctg atgtgaatcg 1094461 atatgtagcg gggcaaattt ctgcgctcga tgtcagatat gaagctgatc gtaccatgcc 1094521 gccgaatcgt ttgaacgggg caaggctccc tgacatgaag ctgattcttt ccgacggcaa 1094581 ttcggaacgg ctgtacagct ttctccaaaa cgggacattc gttttgctgt cattgaggca 1094641 ggaagctgat gatcatatcg aagtaaaagg cttacgtacg gtaaccgcct cgcttgcaga 1094701 accgaatgaa aagttgcgga atgtgcatac catattgatt cgtcccgatg gacatgtagc 1094761 ctgggcggtg gatgcatcag cgcccgattg ttccgaggtg attcaaaaag ggatcagccg 1094821 ctggttttcc gtcaccagcc gagtataatt caattcgatt gtttcatctg taacaaaacg 1094881 gtatgataga agaaacaatc gaatgaaaaa ggatggaaaa cccgatgaac acagatcata 1094941 cgaaacgcaa tctttttgaa ttgtatgcgg agctcattca tcagcaggag aaatgggagg 1095001 ggcttattaa agccttttta tctgacgaat tgaggaagct ggatgtagag cacgggagta 1095061 aatctcaatt gacgatgaca gaaattcatg ttctatcctg tgtcggggac aatgaaccaa 1095121 ttaatgtcac gtcgatagca gaaaaaatga atacgacaaa agcgactgta tcacgcatca 1095181 gcacaaaatt gctcggcgca ggcttccttc acagaacaca gctcagcgat aataaaaagg 1095241 aggtctactt ccgattgacg cctgctggaa aaaagctgca cagtttgcac aaatattatc 1095301 atcagaaggc tgaacagcgt tttctgtcat tttttgaccg ctataccgag gaagagattc 1095361 tttttgcgga acggctgttt cgggatctgg tgacaaaatg gtatccgtcg tcagaagaaa 1095421 ttgaaggggg gcttcctagc atttttaaat aaaaaacacg cactgcggtg cgtgtttttc 1095481 gctttgtttc tatctttttc aaggctgtaa cgtaaatcag atttcctctt gaagaatgaa 1095541 attcaagatg ttcaggaatt tgcactgctt atacgatatg tctattagta tctttatttt 1095601 atacgttttc tactgtgttt ttgatgcttt gttttcaagt gaaatagggt cttctgtttt 1095661 agttctccta atctttacag aaatacctac tagaatgacc gccatagttg taaatattcc 1095721 catggttaat aagatcgtat cctggtttaa actccatcca attaagaaag agatgatcgc 1095781 tcctccgaaa cttgccgagg caataaataa acttgtaact tcgtcaacgt acttctgaat 1095841 aatgattgat gctagtgtta aagcaatggg aaatatcccc gctatactta ggccaatcaa 1095901 aaatgtacca ctcaattgaa gtattgggtt acttatataa gagaaggcaa tcaacaaaac 1095961 aattaaacaa ctacagctaa aaagaaggta tttggaaaaa tcaagccttc tacttacgaa 1096021 accaatcaat attcttccta tgatgatccc tacccagaaa aaggagacac ttataagact 1096081 aatttgttca ttgtcttggt ttatcatgat tgaaggtaaa aagttggcaa aatttgtttc 1096141 aattccagca tataggaaag cgaaaaatac aaaaaagcct aattgctttg atttttttct 1096201 atctcctata aagtattgaa atgctcctcc atctggaaag gtcacttgtt ggttagcatt 1096261 cttagcgtac tctcggttct tagacaagaa aattaaccac cctacgaata ggacgaataa 1096321 aaaggtgaat atacagtaat atggtaaaaa ccagttattg atatctatga aggaattaat 1096381 taataatggg aaagataaag cgcctaatcc aaagagaact tccagcttac tcattttttc 1096441 tgcattactt tcgaaattag caataacaaa tgaaccaact gtcgtttcta atgtgcctgc 1096501 tccatatcct aagagaaaag ccattacaat aatataatac caatccttgg ttagaaaaaa 1096561 gatacttaac gctacaagca ttattgtcaa agctaaagta agtgtcctaa aatgactgta 1096621 tttcttaatc attaaaggtg cgattaatac tccgcttaga aatccggtaa actggaagaa 1096681 gattatgacc gaaatatcat ctgttgtctt gttaaaagcc tctaataaaa atggtgtcaa 1096741 actccctgtt gatatatgga taatacctac tgtaaaaaag aaagcatatc caaataaata 1096801 tgtccctctt aacattcatt acacccctat atgaaaaagc aggaaagtaa attcctgctt 1096861 ttttagtaac ttctctcttt gaaatactag ttgactgctg aaacagacat gggttgagag 1096921 ttgctgtctt tctcaaagaa catttctaat acttcctgag atctaaaacc atcactaaaa 1096981 gaagggatct caacccaatc attctgagtt gatgcaatcc aattgattaa ctcgcttcta 1097041 aaagaatcag cccatccata aaactcgttt ggcggatcgt ttaataggct ttgcggtact 1097101 gggcagtcta ccacgttcaa gccatctatg agcttgtaaa cgtgaggatt acctgtgtgg 1097161 tatttaaact cttttttgtg tccaactacc tcaatgctaa aaccacagtc ttcaggtaca 1097221 gaacactttg atgtgatgat atttacaaat accttgttct tcagctggcc ataaatttct 1097281 gcatagtcat ctacaagtac ctgtttatcc tcttttgttt ttacatttgt gttcatcttt 1097341 gcccttactg attctgtgat gaaatcactc tcgaacaaat accataccat gtcaataagg 1097401 tgaataccca gatcccccaa tgatccactc gtcttcttac tattagcgtc atctctccaa 1097461 gtaaacttct tacgtctaag tgcactattt ttcttgaagt gtacttttat ggacagtatg 1097521 ttacctagtt cattattgat aattaagctt tttaagatat ttacgtaaga taaatatcta 1097581 taattaaatc ccatactggc tcttacgctc aacctttcag cagtatcttt cattatgctt 1097641 gcttcttcaa gagaaatagc cataggcttt tcacataata catgcttatg ttttcctaat 1097701 gcttgcaaag catgttcttt atggcaaaag tttggtgatg ctacaattaa accttctgag 1097761 gcatcaatta gttcatctac gttttcaaat gacttcccgc cgaaagtttt cacaaagctt 1097821 tccgcatttt gttgatttat gtcatatacc cctactaact ctgcattttt tattgtagat 1097881 aaagcagttg catgcgctct tgcaatacca cctgcaccta tgatgcctat cttcttcatt 1097941 tttatttcct cctcatgatc caattaattt ttttaaggta ttagtaattc cttttgagta 1098001 ctcactatca gttataaggt tgtgcaagtt tttggcttcc tgtgttgcat tttttagcag 1098061 atatccattc cctactgtct gtaacatacg aacatcattt ccactatccc caaatgcgat 1098121 agctctttcg gtatttaggt tgtatttctc taacataaac gttacaattt cattctttcc 1098181 tgtccctatg gggataaaat ctacatcata gctgtcttct ggatcgcctg ctaagggatt 1098241 acaccgattt atatttactg aaacgccgta ttcttcgcag attttttcaa tagctaatag 1098301 gtttttcttg tcgtttattt catcttgttc ctgatagtag aagttatgct tataccgtga 1098361 ctttcctaat tgggtttgag gattcaaaag aatgttatga ttttcatgca gctgtttcac 1098421 aagtttttca accttttctt tactaaaccc ttcatttatg cgactgttcc acttgttatc 1098481 ttgctgaccg aagttatgct ctgaaaagta cgtaatttca gttccaagat cactagctat 1098541 aaaatgcgga aaatatctaa attttcctcg tcccatttta tcgagaatag attctatact 1098601 gctcccagta acccatccga ttattagctc cccatcttta cttttttgtt ctagatagtc 1098661 ttcgagttca tagatgtctt gttgcttttg ttcgtcgatt gtatgcggaa aatacgtttc 1098721 atcaaaatca caaaaaacaa tatattgagg atgttcaacc gtggataacg ttttatactc 1098781 cgatttcttg cttaataaca tgaaacagtc cctccattac tctgtcttgt tcttctaaag 1098841 taaatgacgg atataaaggc aaatgcagta cctgactatg agccttttcc gtatgaacca 1098901 attggagtcc tgcatacttg tcctgtacta aaggagtttt ttgcatatga gaaagtattg 1098961 gataatatac atctgtttga acaccaaaat cttcatttaa tttagtcatg atatctgccc 1099021 tatcttctgt tcttacctta ataggaaaca gatgccatac atgatcttca cttaattctg 1099081 gtaattcaat atagccttta ttctgcaact ctgctaattg ggtaatgtat ctatccgcca 1099141 agaacaatct tttgaagttg tttaatgaaa ggtacttcat tctctctaaa ccaattgctg 1099201 cctgtaaatt gtccattttt gaattaaatc caaaattgat gactttctta ttttttacat 1099261 ttacttcaaa accgtgataa ctaaattgaa tgcatttttt agcgagttct tcattatcag 1099321 ttgctattgc cccagccttg ccacatacac caaaattctt atagggatta aaacttaatg 1099381 tagtgatgtc tgcatacttt cctaagtctg tcagtccaat tccttggcag gcatcttcaa 1099441 ttacttttaa tttataacga tttgcgattt gacggatatg ctgcatgtct gaatgttttc 1099501 cgtataaatg cacaggtaga ataaactttg tataaggagt tattgcttct tcaattttgt 1099561 caggatcgat gcagaatgtt tgtgggttaa tatctacata gataggaacg cctcccgaag 1099621 ctaacacagc attttcagta gctgaaaagc tattagccgg catgataact tcatcccctg 1099681 ggtttaaccc taaagccaat aaacctatca taatagcatc ggttccactg ctggttgcaa 1099741 ttacatacct tttatgtaaa tatgtagata aaactttttc gaattgctct aaatagggac 1099801 cactcgtaaa ttttccagtt ggcaaaactt cagttaatgt atttaagata tcttccactt 1099861 catcattggt tattaatctg tctacaggca aaaaagggac tttactgatt tcacgatttt 1099921 tttgatagtt gaaaaggtca tgttcaatat ctatcttttc ttttaatact tgtttccacc 1099981 gctcgtttac aatactgtct tcaataacaa gttcttttcc ttgtacgtca ccttttaagt 1100041 gttttaatag tgacatgttt tctttgcttt tacctgaaat cttaacctgt ttttgcatga 1100101 acagtacctc caatgatttt ataatctaaa aatttattac aaatttatcc tagtttctga 1100161 aatcggtaac atgtcaacaa cttttttaag gaagggaaaa tatgcctaca attgatgaaa 1100221 tagcaaaatt atgcaatgtg tctaaaacca cagtgtcaag agtattgaat aatcatcctt 1100281 atgtgtcgaa agaaaaaaga gatatgatct taaaggctat taacgaactt gactacactc 1100341 ccaattattt agctcggaat tttaggagaa ataagacaca aacgatagct ttatcggttc 1100401 cgagtatcga ccatccattt tttgctcaat taataaaagg ggtctctcat gaagtactgt 1100461 ttaagaatta caaggtaatt gtatttcaga ccttttatga caaacagacg gagctagaat 1100521 tactagagtt attgaagcat aaagaagtgg atggcattat tcttgggact ttagaaaatg 1100581 aatgggatca gatatcccct ttcttaaagt atggtcctat cttattatgt aatgaatatc 1100641 atcactcagc ggacatcacg ataattgggt atgatgaatt tgaagccgca tacatggggg 1100701 tagtacattt aattgaaaga gggcataaaa aaattgggtt ttgttttgat actccatata 1100761 gcgaagctca atgtcagagg aaagagggtt atttgaaagc tttacaagat tacaatttac 1100821 atcatagaag cgaatggata ttcggcgaaa tgtttaatat cgaggatggc tttcgtgttt 1100881 ttcataagat aaaggatcta aaggacagac cctcagcaat atttacagga aatgatcaag 1100941 tcgccgcagg gattattaaa caggcgatga aaaatggctt taaagttcca gaagacttag 1101001 ctgtaattgg ttttgacaac caattgattt gccaagtcgt tactccgacc ataacaacaa 1101061 ttgatatccc cgtaatagaa ttaggccaac aggctgtgtt gaaaatcatc gagtccattt 1101121 cgggtaatgc ctctttaaac agaagaatta ttaaactgcc aacaaagctt attataagag 1101181 aatcaacgta acgatagatt tccctttaac attttatatc tttatataag aaaaagaggt 1101241 tattcatttt aacctctttt tcaatcgtaa gtcgtcaatt atttctttca tttcaccctc 1101301 tggcagcact cacttcaaat ctgatccatt aacaacgaaa tatccgctta tatttcctca 1101361 tctcgatggt ttgcgaatta aaagttcttg aacccttttt tcaactaggc actactgccg 1101421 ctgattgagc tctttttgtc ttttttttca ccatgaagat ggtgaagcag gcgataaaac 1101481 ggcggcagca gggcaataac cagaatgacg cgaatgacct gaaccgcaac gacaaaggtg 1101541 gaatcagcat gtaaggtaac tgacgtcgtc gccatctctg caatcccgcc gggcgcaaat 1101601 gccagaacag aagtgatgag cgaaattcct gtcagctcgg aaacgatcac ggcgctcaaa 1101661 aacattgctg cgattaaacc gacggacgag acaaacccga cgatgataat acgggtgacg 1101721 ccggcaaaca tgcttttgta catcttagag ccgatcgttg ccccgagaaa tacttgtgat 1101781 acatggttag cttgtgacaa ccaccatgcc gtcatgtcgt gccctgtcac cgcagctccg 1101841 ccaacatgta caattgctac accgagcatg ctgccgagca gccatggagc tggaaatttt 1101901 aaaaatttcg cagctttgca agctccccag gcagcgagaa taagaatgac ggtccacaaa 1101961 acgggagcga gcctaaaatc tgtcgttgca gaagaaatcg tctctgctgc ggcacttgcg 1102021 gtacgatctt gttttgtata gatcagaatg actaaaaacg gaatggaaag caccacgagc 1102081 agcacacgca tcatttgaac gaggctgact atagcggtat tggcgcctac ttcctgtgcg 1102141 atgctcggca tggcggaaag tccgccggga gcggtgccga caaagctagt catcatatcc 1102201 gttttgctga aacgccaaag cacatatcct gacagcatgg ccagcaggat agacaatatc 1102261 agcataacgc cgactgaaaa ccaatggtct ttgagaacag agagaacgga taaattcagc 1102321 ttttggccca attcgatgcc gaggatcatc tgcccgaggg cgagccatcg tcggttaatt 1102381 cctttttggt ctggtgccat catcagccat gccggccgta tcatggcgag gcagcaggcg 1102441 acaatcagtg ttccgatcat ccatccaatt gatattccgg ttaatgaaag aataaacccc 1102501 ccggctgcac tgattgcgat aaaccataga tctttgagga gattttcgtc tttcttcaat 1102561 gtaaaaccct tcttcctttt tcacgtaaca ctccaattgt tcacgtagtg aatgtattta 1102621 ttactatagt atatttttgt tgataaagaa attatgaatt attttctata agcgattcac 1102681 ttttcttatg accttgtgtt cgagcttttc tattgtgtaa gtcagagata aacccgctgt 1102741 cagcagacac acggcaagag cgtaaaaaat cacttctccg ccaaatgatg tcaggatcag 1102801 cccgcctgcc agcggtccga ttgagcggga tatatcccaa tgcagaccat agacagcata 1102861 aaaccggccc agcaaatgag gcggcgccaa tttcgatatg aaggtctgga tgtgggttag 1102921 cccgatgctt tcaccaaccg tcatcaccgc tgccgtcact aaaagcattg tcagagaggt 1102981 tgagcatgca aagccggctg ccgcaaggga gtagcaaata taagtaatga agaggatcgt 1103041 tttcattgaa agcttttcgg tccctttgac aagaggtact tggagaacac agctgaataa 1103101 agcttttgct gctgaataga tggtcagcat ggacagataa tcagaaaaca tgtttttgct 1103161 gaacagcctg tatgttgttt ctgtttgtgc atataacatg ctgatgggga gagaaagcag 1103221 caaaagaagc aggacaggcc tgtatattgt aaagctcgcg gacattttcg gggtaacagc 1103281 tgggtgtagc ggctttgtct caggcagttt cagtgcagcg atcagaaagt agataaacaa 1103341 tgctgcagca tctaatgcga atatccacac ggggttatga ttgtacagca gcatccccac 1103401 tagcggtcct gccgtcagac ccgtcgaata gatcgcattg atgaccgcaa acacttccga 1103461 acgtctgctt tccggcgtgc tttcagcgat ttgggcgcgg gaagcgggaa tgtacaacga 1103521 tcttccgatg ccattcatga catagagaat agcgaaaaca tacgcatgct cagcaaatac 1103581 aaaccctgtc attgccgctg attgaagaag caatgcggtc aaaatcgctg tgcgccgccc 1103641 aagccgatcc gtcacccgtc ctgcagcgag cgtcaggaaa atatcagcaa atggctgaag 1103701 gctgatgatc agcattggca tcatgatact gccgtttaat tgttcatgca gatacagcac 1103761 cataaaaggt cccatcattg cacctgtcag gcttgtcagc aattcgccga aaaagcggag 1103821 ccgaacggga gcggtatatc tcgattttat agagtgaaaa ctggtcaaca tgtgatcgcc 1103881 gcctttcgct gtttgatata gtagtagtgt atagaagggg cggcggccca aaaagtgaag 1103941 aaaagaagag ataaaagttc cccttttgtc gggaggtgcg gggattgaag ctgatagagc 1104001 actacgtggc gcttgtaaaa acaggctgcg ccgagtatgg gcaaatgaac gaaatgacgc 1104061 tcactgagat tgccgactgt ttattttgta cagaaagaaa tgcaaagctc attttacata 1104121 agctggagaa cagcaattgg attatccggg aaagcggggc ggggcgcggc cgcaaatcta 1104181 aaatcgcgtt tcttcggagg cctgaggaac tgcttcttca aactgcaaag gaatatacca 1104241 tgtcaggaaa gcttaaaaag gcaaaggagc tgcttcagca gtatcagtcc gcgtttccag 1104301 ggcttcaaaa cgaatataac atgtggctat cagaggtatt cggatttgtg acggagacag 1104361 gcgagaatgg ggcgaaggat gtcctgcggc tgttcatcac gcctgaatct gtcagcagtt 1104421 tggatccatg ccaaatattt ttgcggtctg agggccattt cgtcaaacag atatttgata 1104481 cactcttcac gtttgattcg gatatgcagg agccgaagcc tcatttggtt catggatggg 1104541 aagaggtcgg aaaaaaacaa tggagatttt ttcttcgaaa aggtgtgtta tttcataatg 1104601 gacagccgct gacatcgcgg gacgttgcgt ttacatttca gcgctttttg gaactggctg 1104661 acaacccgta taaatggctt ctgcacggag tgaaacaagt cttagaaaag ggcccttatt 1104721 gtgtggagct catactcgat aagccgaatg cgcttttgcc gtatgctctt tgtgatgaac 1104781 ggctgtccat actgccggca gaacagggcg gcgggaaaaa tggaacaggg ccttttcaga 1104841 tgaatcagca acatagcggg atgcttgtgc ttgaagccaa tgagcgctac ttcaagggac 1104901 gcccctattt ggatcgcgtt gagtttgtgt tttctgagca agccggagag atgaacggtt 1104961 ttaccattca agaaaaacaa acatgtcctg agcagcaaac tgtctttgat gagcggcatg 1105021 ttcagtattt gtcgcttaat ctgaaaaaga aggggcctct tcagcaccga agctttagaa 1105081 aagcgctccg gctgctgatt tcctctgaac ggctcgttcg tgaagcggga gggcaccgaa 1105141 gaattccggt tacgtccttt ttgcatccga gtccttttga gtgggagggc gtttcgccat 1105201 ctgaattgtt gaaaaaaagc ggatacgagg gcgaaacaat cgtgctttat accttttcgg 1105261 aaacggatca tcgtgaggac gccgaatgga ttcaaaatat ttgcgcccag cacggtatca 1105321 ggcttacact tcaattctgt gatgctgctg atctgcgacg gccggaaatc gtgcagatgg 1105381 cggatatcat tcatgacagt gcgacgtttt atcaagacag cgagtttggt tttctgcatt 1105441 tgctgctgtc ggagaacagt ttcttgtatc agcatctatc tgaaaagctg acacagattt 1105501 gctcaggaat gacagagcgg atgttttcca tgcctgaccg ctgttcgaga atcaacatcc 1105561 tgcgtgacat tgaccggcag atgatacagg agctgaacgc gatcccgctg tatcaaaatg 1105621 tgctccaggt gacatcaagt aaaaatgtaa aaggcctggt gcttgatgaa gagggatgga 1105681 ttgatttgta ctccgtatgg ctgtccaaat aaaaagaggg ttcttttttg aaccctcttt 1105741 tttacgctgc catgctgcgg cattgttcag cacaggtgaa gcaggctttc gcacatgctt 1105801 ggcaatgatc atgatcgtgc tttccgcatt cagtgccgca tgcttcacaa atatcggcgc 1105861 aaagtgcaca aatttctttc ataaacgggc tgtccgtttg catggctttg accgccagcg 1105921 cgcaaatatc cgcgcattcc ctgtcaagcc ggatgcatcc gctgagatga tgctgcacgc 1105981 tttcttccaa gcatttagtg aaacaatgat tgcaagcctt catgcaatcg atgcaagcct 1106041 caatacaagc ctcagaatat tgctccatgg ttgattcccc ctgtatgaca gtatatggtt 1106101 ttatgtttca cggctgcatt tgaaaaaaac aggggagtgt gtttttagct aaggggatat 1106161 gtacatatac cctgaatggg tatatctaac gttccatcag atagtatagg aaccagacag 1106221 cgtgattttg ttcatcacgt gctgcgcgcg taaagacgcc tttcgctttt aagtttgacg 1106281 tttcctcggc cgcacgcaag taaaagtcga cggtttcttg ttcatcttta aaagcggcgt 1106341 ccagtcctct tgtgaaattg tccgggcatt cttccgtttg tttcggcatg atgtgtttgc 1106401 cggtaattga accatacagt gtggaaaatt cacggaggtg gcgaatctcg tcacgcctga 1106461 tttcttcaat ctgttttctg acctcatcgc tgtgggcgag ttcggcaagc ttgcggtagc 1106521 attgaatagc actgaattct ccgttgatgg ccttctgcaa attccgaatc aaaacaggat 1106581 cttcccggta tggcaccgga tagggatagt agctgtaatg caaggggatt caactccatt 1106641 cttaggaatt gggcttctgt aaaagtatat gttgggcagg gagagatgtg cggagataat 1106701 cagcttttta tatgtgaaaa ggccgttttt accaatagat cagattggtc attttcgtca 1106761 acattcgata aaatatagag agataaaaag agaggggtct tctaatttgg gagcagagtt 1106821 tttagtaggc aggtccggga gtggaaaaac gaagctgatc atcaacagca ttcaggatga 1106881 attgcgccgg gctccattcg ggaagccgat catttttcta gtcccggatc aaatgacgtt 1106941 tttaatggaa tacgagcttg ctaaaacgcc agatatgggc gggatgatac gcgctcaagt 1107001 gttcagtttt tcacgattgg cctggcgcgt cctccagcat acgggaggaa tgagcaggcc 1107061 gtttctgacg agcaccggcg tacaaatgct cctgcggaag ctcattgagg agcataaaca 1107121 ggagttcaaa gtctatcaaa aagcgagtga caaaagcggg tttaccgcac aggttgagcg 1107181 gatgctgaca gagtttaagc gctattgtct ggaaccggag gatatccgcc ggatggcgga 1107241 aagcggaacg gcttccgagt atcgcggaga acgtgtttta tctgaaaagc tccatgactt 1107301 atcaattctg tatcagcaaa tggaaaaaag cctcgcagat caatatcttc actctgagga 1107361 ttatttgaca ttgctggcag agcatatccc gcttgcggaa gatataaaag gcgcccatat 1107421 ctatgtggat ggcttttatc agtttacccc gcaggaattc agggtgttgg agcagcttat 1107481 ggttcatgcg gagcatatca cgttttcgct cacagcggac aagccgtcat atgagcggga 1107541 gccgcatgaa ctggaattgt tcagaatgac ggggaaaacc tattaccgcc tgcatcagaa 1107601 ggcgaaggaa ctgaatttgg acattacgta taaagagctg agcgggactg agcggcatac 1107661 aaagacgccg gaattggcgc atctagaggc acagtatgaa gcgcgtccgg ccattccata 1107721 cgcagaaaaa caagaagccc ttactgtgat gcaggccgca aacagacgag ctgagctgga 1107781 aggcattgct cgggaaattc acgccctagt cagagagaag ggatatcgct ataaggatgt 1107841 agcaattctt gcgcgccagc cggaagacta caaggatatg gtgaaggaag ttttcgcaga 1107901 ttacgagatt ccttatttca ttgacggaaa agcatctatg ctgaaccatc cgttaattga 1107961 atttatccgg tcgagccttg atgttctgaa agggaattgg cgttatgaag cggtgtttcg 1108021 ctgcgtgaaa accgaactgc tattcccgct caatgaaccg aaggccaaag tgagagaaca 1108081 ggtcgatcag ctcgaaaatt actgtatcgc ctatggtatt aaaggcgacc gctggacaaa 1108141 gggcgatcgg ttccaataca ggcgttttgt gtcattggat gatgattttg cgcagactga 1108201 tcaggaaatc gaaatggaaa acatgttgaa tgacacccgc gattggattg ttccgccgct 1108261 ttttcagctt caaaaacgca tgaaaaaagc gaagacggtt caagagaagg cggaggcgct 1108321 ctatcgttat ttagaagaga cggatgtgcc gctgaagctg gatcaggaaa ggcagcgtgc 1108381 tgaggatgac ggcagaatca ttgaagcgca gcagcatcag caggcgtggg acgcagtcat 1108441 tcagctgctt gaggagtttg ttgaaatgat gggagatgat gagatttctc ttgatttgtt 1108501 tcagcaaatg atagaagccg gcgcggagtc gcttacattt tctctaattc cgcctgcgct 1108561 tgaccaggtg tttgtcggca atatggattt gtccagaatg tatggcacct cctgcacctt 1108621 tgtgctcggg gcaaacgacg gcgttctgcc ggcacgccct gatgaaaacg gggtcctgtc 1108681 ggatgatgac cgggaatggc tgaaaacgat tggggttgag ctatcctcag gcggacgaga 1108741 gcgtttgctt gatgagcact tcctcatcta catggcgttt tcaagtccgt ctgaccggct 1108801 ttacgtatcg tatccgattg ctgatgcgga aggaaaaacg cttttgccgt cgatgatcgt 1108861 taagcggctg gaagaactgt ttccgcatca taaggagcgc ctgttaacaa atgaacctga 1108921 acaggtcagc gatgaggaac agctgatgta tgttgtgaat aaaagcgtgg cacagtcctt 1108981 taccgcgagc cagctcaggt tatggactcg ggaatacgac atcagcgacg tctggtggag 1109041 cacgtacaat gtgctgatga gtgagcagga caggctgcaa tcgaaaaagc tgttctcaag 1109101 cctgtttttc cggaatgaag tgaagcagct tgaacgcagc gtgtcgagac agctctatgg 1109161 tgaacgtatt cagggcagtg tatcgagaat ggaaaccttt aacgcatgcc cgttttccca 1109221 ttttgcgtca cacgggctgc atttgaagga acggcaattc ttcaagcttg aagcaccgga 1109281 tatcggccag ctgtttcatt ccagcttaaa gctgatttcg gacaggctgc gtgagcaaaa 1109341 gctggattgg cgcgatttaa cgaaggagca gtgcgagctg ttttcctatg atgcggtaga 1109401 gcggctggca ccgaaactgc aaaaggaaat tctgctcagc tcaaaccggc attattatgt 1109461 gaaggaaaaa ctgcaaaaaa ttgtgacacg tgtgtccggc attttaagcg agcatgcgaa 1109521 agcgagcgga ttcgtaccga tcgggcttga actgggcttt ggaggaaaag ggccgcttcc 1109581 gccgctgacc tttcaactga aaaacggctg tacgatggaa ctcgtcgggc gaattgaccg 1109641 tgttgataag gctgaaagct caaaaggcct gctcctcagg attgtcgatt ataaatcaag 1109701 cgacaaaggc cttgacttag cggaagtata ttacggattg gcactgcaaa tgctgacgta 1109761 ccttgattta tcgattacac attcagctga ctggctcggg atgagggcga cgcctgccgg 1109821 agtgctgtat ttccatattc atgacccgat gattcaatct aatctcccgc ttgggcttga 1109881 cgagattgaa caggagatct ttaagaaatt taaaatgaag ggcttgctcc tcggtgatca 1109941 ggaagtggtt cgcctcatgg atacaaccct tcaagaggga cgttcaaata tcataaacgc 1110001 cggcttgaaa aaagacggct ctctcagatc agactcagca gcagtcggtg aaaaggaatt 1110061 tgatcttttg acaaagcatg tgcgccgcac cttccaagaa gcgggcgaac aaatcaccga 1110121 cgggcgcgta tccattgagc cgtacaaaat gaagaacaag acgccgtgca catactgtgc 1110181 gttcaaatca gtatgccaat ttgatgaatc actggaagaa aacgagtatc gcccattaaa 1110241 ggctgaaaag gacaagacaa tacttgagtg gataaaaaag gaggcggatg gcaatgaaca 1110301 ttcctaaacc ggcagacagc acatggacag atgaccaatg gaatgccatt gtttcaaccg 1110361 gccaggatat tcttgtggca gcggctgcgg gctctggtaa aaccgctgtg ctcgttgaac 1110421 gaatgattcg gaaaatcacc gcggaggaaa acccaataga tgtagaccgt cttctcgttg 1110481 tgacatttac aaacgcctca gcggcagaga tgaagcaccg aatcgcagaa gccttggaaa 1110541 aagagcttgt acagcgcccc ggctcgctgc atattagacg ccagctgtct cttttaaacc 1110601 gggccagcat ttcgacgctc cattcctttt gcctgcaagt gctgaagaaa tattactact 1110661 tgatcgatct tgatccgggc tttcggatag ctgatcagac ggaaggcgag ctgatcgggg 1110721 atgaagtgct tgacgagctg tttgaagacg aatacgcaaa gggcgaaaag gcgttttttg 1110781 agcttgttga ccgctatacg acagaccggc atgatctgga tctgcaattt ctcgttaaac 1110841 aggtgtacga gtattcccga tcccatccca acccggaggc gtggctggaa agctttgttc 1110901 atttgtatga tgtatcagaa aagagcgcca tcgaggagct gccgttttat caatatgtca 1110961 aagaagatat tgcaatggtg cttaacgggg cgaaggaaaa gctcttgcgc gcgcttgagc 1111021 tgacgaaagc gccgggcggc ccggcgccgc gtgctgacaa ttttcttgat gatcttgctc 1111081 agattgatga actgattcag catcaggacg atttcagtga actatataag cgggtgcccg 1111141 ccgtctcttt taagcgtgcc aaagcagtaa aaggggatga gttcgatcca gcgctccttg 1111201 atgaggcgac agatttgagg aacggcgcaa aaaaactgct tgaaaagctc aaaaccgact 1111261 acttcacgcg aagtcctgaa cagcacttga aaagcctagc cgagatgaag cctgtcattg 1111321 aaacgctcgt acagcttgtc atcagctatg gaaaacgatt cgaagctgcg aaacaggaaa 1111381 aatcaatcat cgatttttcg gatttggagc attactgttt agcgattttg acagctgaga 1111441 atgacaaagg tgaacgtgag ccgagcgagg ctgcaaggtt ttatcaggaa cagtttcatg 1111501 aggtgctcgt tgacgaatat caggatacca acctcgtgca ggaatcgatt ctgcagctcg 1111561 tcacaagcgg tccggaggag actggtaacc tgtttatggt aggagatgtc aaacagtcga 1111621 tttatcgatt caggcttgcg gagccgcttc ttttcctctc taaatacaaa cggtttacag 1111681 agagcggaga aggcacgggg cggaaaatcg atttaaataa aaatttccga agccgggctg 1111741 atattttaga cagcacaaac tttttattta aacagctgat gggcggcaaa atcggtgagg 1111801 tcgattatga cgagcaggct gagctgaagc ttggtgcagc gtatccggac aatgacgaga 1111861 cggaaacaga gctgctgctg atcgacaacg cagaagatac ggatgcaagc gaggaagcag 1111921 aagagcttga aacggtgcag tttgaggcaa aagccatcgc taaggaaatt cgtaagctga 1111981 tttcatcgcc gtttaaggtg tatgacggaa aaaagaaaac acatcgcaat attcaatacc 1112041 gagatatcgt gattttgctc cgttcgatgc cgtgggctcc gcaaatcatg gaggagctga 1112101 gagcacaggg cataccggtt tacgccaatt taacgtcagg ctattttgaa gcggtcgaag 1112161 tcgccgtcgc gctttctgtg ctgaaggtga ttgataatcc gtatcaggat ataccgcttg 1112221 cctctgtgct gcgctcaccg attgtcggag cagatgaaaa cgagctgtct ttgatccggc 1112281 ttgaaaataa aaaagcgccg tactatgagg cgatgaaaga ctacctggct gctggtgacc 1112341 ggagcgatga gctttatcaa aagttaaata cgttttacgg acatctgcaa aaatggcgcg 1112401 cgttttcgaa aaaccactca gtatctgagc tgatttggga agtgtaccgc gacaccaaat 1112461 atatggatta tgtcggcggc atgccgggcg gaaaacagcg ccaggccaat ttgcgtgttc 1112521 tttatgacag ggcgcgtcaa tatgaatcaa cggcatttcg cggcttgttc cgtttcctgc 1112581 ggtttatcga acgcatgcag gagcggggcg atgatcttgg tacggcgaga gcgctcagcg 1112641 agcaggagga tgttgtccgc ttaatgacga tccacagcag caaagggctc gaatttccag 1112701 tcgtgtttgt agcaggtctc ggccggaatt tcaacatgat ggatttgaac aaatcgtacc 1112761 tgctggataa ggagctcgga tttggcacga agtatattca tccgcaatta cgcatcagct 1112821 atccgacact tccgctcatt gcgatgaaga aaaaaatgcg cagggagctg ctgtcagagg 1112881 aattgcgtgt gctctatgtt gcattaacga gagcgaagga aaagctgttt ctgattggct 1112941 catgtaagga tcatcagaaa cagcttgcaa aatggcaggc atccgcgtcc caaactgatt 1113001 ggcttctgcc ggaatttgac cgctatcagg cgagaacgta tctagatttc attgggccgg 1113061 ctcttgccag gcacagagac ttgggggatt tggctggtgt gccagcacac gctgacatct 1113121 caggtcaccc ggctcgtttt gccgttcaaa tgatccattc ctatgatttg cttgatgatg 1113181 atctggaaga aagaatggaa gaaaaaagcg agcgcctaga agcgatccgc cgaggtgaac 1113241 cagttcccgg ctcgtttgcg tttgatgaaa aagcccgcga gcagctgagc tggacctacc 1113301 cgcatcaaga agtgacgcaa attcggacaa agcaatcagt ttctgagatc aagagaaaaa 1113361 gagagtacga ggatgaatac agcggcaggg cccctgtaaa accggctgat ggaagcattc 1113421 tgtacagacg tcccgctttt atgatgaaaa aaggcctgac agcggcagag aaagggactg 1113481 ccatgcatac ggttatgcag catatcccgc tgtcacatgt gccgtcgata gaagaagctg 1113541 agcagacggt tcacaggctt tatgaaaaag agcttctcac tgaagaacaa aaagacgcta 1113601 ttgatataga agaaatcgtg caatttttcc atacagaaat cggcggacag ctgatcggtg 1113661 ctaagtggaa ggaccgggaa ataccattca gcttagcgct tccggccaag gagatctatc 1113721 ctgatgcaca cgaggcagat gagccgcttt tagtgcaggg tattattgac tgtctctatg 1113781 aaactgagga cggattatat ctattggatt ataagtcgga ccggattgag ggcaaattcc 1113841 agcatggatt tgaaggagcg gccccgatct tgaagaaacg atatgaaacg caaattcagc 1113901 tgtacacgaa ggcagtggag caaattgcaa aaacaaaggt aaagggatgt gcgctttatt 1113961 tctttgacgg agggcacatt ctgacattat agcgagatcc ataagctccg gaatttcagg 1114021 cggagcgggt ctcgttttct atataaaaga gaggtgaaag catttgcgga ttttacatac 1114081 ggctgactgg catcttggaa aaacgcttga aggaagaagc aggctgagtg aacaggccga 1114141 tgtgctggat gaactgaata cgattgtaaa ggatgagcag atcgatgcca ttgtaatggc 1114201 gggggatgca tttgacaccg taaacccgcc agctttagcc gagcagctgt tttatgaaag 1114261 cctgtctgcg cttagcgaca gaggaaagcg cccgatcgtc gtcattgccg gaaatcacga 1114321 taatcctgac cgtttgtccg ccgcttcacc gctgacacat gaaaacggca ttcatttaat 1114381 cggttatccg acaacagagc cgattcatat tgaagtgcct tcagcaggag agcttttggc 1114441 ggttggagcg ctggcgtacc catctgaagc gcggttaaat gaagtgctat ccgatacgtt 1114501 tgatgaaaag ctgctccgtg atcactatga tgtgaaaatc aggcaggcgt ttgagcatat 1114561 gacaagccgg ttccggaccg atgcagtgaa gattgccgcc agccatattt atgtggcagg 1114621 cggaaaccaa accgattcag agcggccgat tgaagtcggc ggtgcataca cggtggctgc 1114681 tgaaagcctg ccggcagatg ccgcttacgt tgcgctcggc catttgcatc gcccgcaaac 1114741 gatcaagcgg gcgcggacgc ttgcgcgtta ttcaggatct ccgctcgcct acagcttttc 1114801 tgaagcgggc tacgctaaat cagtgacgat tgtggacgca aagcctgggg aagaggccac 1114861 ttggcaagag gtgttattat caagcggcaa gccacttgtg aagtggaaag cggcaaatgg 1114921 attaagtgag gtgtacagct ggctggatga aggcagagat cagaatgctt ggattgactt 1114981 ggaaatccgt gtcgcggacc agctgtcact tgaagagatt cacaggctgc ggaaggcgca 1115041 cccgggcttt atccatatca ggccggtttt tgaagaacag aacaaagacc gggaacggat 1115101 cgaggttaaa catgtctcaa tcgaggaccg ctttaagaaa ttttatgaaa aacaaactgg 1115161 cggtgcggtg ccggatgaag aaatggtgaa gctgttttta gagcttgcat caggcgttga 1115221 agaggaggat gcgaaatgaa gccgatcgcc ttaagcatta aggggctcca cagctttaga 1115281 gaggagcaga cgatagattt tgaaggcctt tccggtgccg gtgttttcgg cattttcggc 1115341 ccgacaggaa gcggtaaatc ctctatactc gacgcaatga cgcttgcttt atacggaaag 1115401 gtggaacggg cggcgaataa tacgcacgga atcttaaatc acgccgaaga tacgctgtct 1115461 gtgtccttta cctttgcgct tcagacgaat caccaaatct catacaaagt cgagcgtgtg 1115521 tttaagagaa cggatgaaat gaaggtaaaa acggcacttt gccgcttcat cgaaatcaag 1115581 gacgagcata cggtgctggc tgataaagcc agcgaagtga ataaaagagt ggaggagctc 1115641 ttagggctga cgatcgacga ttttacgaga gcggtggtgc tgccccaagg gaaatttgct 1115701 gaatttctgt ctttaaaagg ggcagagcgc aggcatatgc ttcagcgttt atttaatttg 1115761 gagcaatatg gagacaggct tgtgaaaaag ctgagacggc aggcgcagga agccaatgcg 1115821 agaaaaaatg aaatgcttgc tgaacagtcc ggtctcggtg aggcgagctc agaggcagtg 1115881 gagcaggctg aaaaggttct cgaacaagct gaagcccggc tggaagcgat gaggaagaac 1115941 cgtgatcagg cgaaggagcg gtttacagag catcaggaga tatggaatgt ccaaaaggaa 1116001 aaatccactt atgaagaaga ggaaaaacgt ctcgcagaag aacagccgca tatagacagc 1116061 atgcaaaaac gcctgctgga agcagaaaca gcagcagccc ttaagcccta tgcggaccgg 1116121 tacgcagaag cgatccagca tgaggagcaa gctgaaaagg aacaaacgct agcccaaaag 1116181 gatttagcag accggacagc tttctttcag caaaaacatg aagagtatga agcgtggcgc 1116241 cagcataaaa gcgagaaaga gcctgagctt ttagccaaac aggaacagct ttcacgcttg 1116301 caggaaatcg aaatcaaact gagtgaggcc aagcaagagg aagagcgcaa aaaggctgac 1116361 ctccggcaga aagaagaggc tcttcaatct gtcatgaatg aattagagac cgtaacagac 1116421 cgcctgacac gagggcaaaa cagacagaca gaattgaagc agcagctcaa atccctgcag 1116481 gtgacatccg atgagcgaaa aagctgccag caggccgcag agatggcatt gcgcatcaga 1116541 caaaccgagg aacaaatcaa aaaagagaaa aaacgaagtg aagaattgaa cctcgtgctg 1116601 cagaagatga atgaagagaa gaatacactc gttcaaaaga cggaagcgga agaaaacaac 1116661 atcattcagg catatgaggc agttcaaact gtgtaccatt tggtgtgcga aacggaacgc 1116721 tcattaacac gtatgacgga agaggctaga aagagtcaac acacgcttca cttacagcgt 1116781 gaaaaagcaa gggtggcact gctgacaaaa gagttagccc aaaagctgac tgccggaaag 1116841 ccttgcccgg tatgcggttc aaccgatcat gatccatctg cctcggtaca tgaaacgtat 1116901 gaagccgaca gccatcttga agaggacatc aaacggacag atgtgttatt gacggaagct 1116961 gcagctctca gccaggagat tctttcagcc aaaattatgc ttgaagaaca gtccgcgcgc 1117021 tttattgaac agtgtccgtt tttgcagaca attcaagcac agaaccttga agcggcagct 1117081 tccttcgaac atcagccggt gtatgaagca tttgaaactg ccaaatttga atggaaacga 1117141 atcaagcagg acattctttc tgttaagaca cgaatggcac aaatgattgg cgcctatcag 1117201 gagtctttaa aaaaggccga gcagcttaat gaaaaaatcg gttttgaaaa aagagaagcc 1117261 gaccgtattg aaagcatcat cagtgagctt caatcctcaa tggacagcag tctgaacatg 1117321 tttaaagaag catttcagaa tcaatctgtg gacgaagcag aaaaatggca gcaagccatt 1117381 gaagaaaagg accgggctgc agaagaatgt gaaaaacgaa ttgagaagag tatcgcgttt 1117441 cttgctgagc atgaagcaca aaaggaaaaa ctgcgggaat cgggacaccg gcttgagcgg 1117501 gaaaagctgg agcttcatta tgcggctgaa cgcatcaaga gcgtgatagc tgattatgag 1117561 cacgaactcg gagattatgc aaaaggagat tcgattcaaa tcaaactccg ctctgtccag 1117621 caggatctaa agctgttaaa ggaaaaagaa caatctttat atgaagaact gcaaagcgcc 1117681 caaatgaagc tcaaccaagc gaaaagccgc gcttctgcaa gcgagctcac tcttcaagag 1117741 gcgaagggca gattggaaaa agcaaaagct gcttggcttg agcatacaaa aaacacctcc 1117801 attacccgga ctgaggaggt tgaacaaagt ctcatcccag ctgatgaact tgaaaagatg 1117861 aaaaccggca tagaccagtt tatggataaa ctgaagcaaa atgctgcaaa cttaaaacga 1117921 gtagcagaga tacttgccgg cagagcatta tcagagagcg aatggaacga aaccgttgca 1117981 gcattacaag aagctgagga cgcatttggc gctgctatag aggaaaaagg cgcggccgca 1118041 aaagcactgg ctgtcattcg cgaccatcat aaacggttta atgaaattga agctgaactg 1118101 aaaaaatggc agatgcatat cgacaggctg gacaagctgc aagctgtgtt taaaggcaat 1118161 accttcgtcg aatttttagc tgaggagcag cttgaaagcg ttgcgaggga cgcctcagca 1118221 agactcagta tgctgacaag acagcgctat gccatcgaag tagattctga gggcggcttc 1118281 gtgatgcggg atgacgcgaa tggaggcgta cgacgcccgg tttccagttt gtctggagga 1118341 gagaccttcc tcacctcgct ttcacttgct cttgcgctgt ctgcgcagat tcagcttcgg 1118401 ggggaatacc cgctgcagtt ctttttctta gatgaaggct tcggcacact ggatcaagat 1118461 ctgcttgata cggttgtaac ggccttggaa aaacttcagt cagacaacct ggctgtcggt 1118521 gtcatcagcc atgtgcagga actgcgtgca cggcttccga aaaagctgat cgtccatccg 1118581 gctgaaccga gcggccgcgg tacgcgggta tcacttgagt tgatgtaagg gaggagcgga 1118641 tatggcaaag cagattgccg gaatatgtga gctgtgcggc cggagcgatg tccagctgac 1118701 agagcatcat cttacaccga aagaggaagg cggaacgttt ttgccgacag cgatgctctg 1118761 tattccttgt cataaacaga ttcatgcctt atataccaat caagagctcg ctgtacgttt 1118821 aaatggaatg gctgaactca gaagcgatcc agagcttgcc cggtttgtca aatggatcag 1118881 aaaacagccg cctgagaagc tgatcaaaac taagaaatca aatgaacgaa aaaagaaaaa 1118941 atgactaaaa agcagccctc tctttgcaga gcggctgctt ttatccgttt ccaaccatat 1119001 cctgatcgtt gacatcgggg tctatataat ttgtcgcgtt gactgcatta tttaatagaa 1119061 ggaaatctcc cgtgtttcct gctcccgaac cgagcgcaga ttttgaagag cttttcggag 1119121 aaaggtaaaa ggaatcacca aagtttacga ctccgcccga tatggaattg atagctatag 1119181 gcccgacaat tgctggcata aacgacaccc tttatcgaag tctctgttta ttatatgttc 1119241 ttggcgggcg attgtgagcg cggagactga atctgtctga tatgtttgag tctcgcatca 1119301 ccgcgaataa gcgaagctga tccggcatgt aaaacagaag aggctgagac cccttgaatt 1119361 ttgatgctgc gaacataaat agccggcacc tcgtggcaaa acgcgctttg tacacctgtt 1119421 tcggggagcg gcttcacggc ctgctgctga aagatctgat actccttttt gttaaatgag 1119481 ccttcattat ggtaaaacgt ggacagagaa cgctgcacag caaatacttt tacactcata 1119541 tcgatttcat ttgtgtcgcc aacttgaaac acacttgcga tcccgagaga attaaactta 1119601 actagtctga tgcgcgatat gcgtttaagc attattctgg cgcaagcgga gcaaacggcc 1119661 caataataag agattcaggc ggtgtatcaa aaatagaaga caggtagatg gattcagtgt 1119721 ctccgatgtg gaaaacggag gaactggaca caccgttcat ccgaatatcc ccgacttcca 1119781 agctgcggtt gatgactgta aagatcatgc ttgctcatct cctttcattt ctgatggaat 1119841 atgctccaga aagtgttcta cagcgcggat gacatcacgc ttcacatgct cagcgatatg 1119901 ttctgcatat tgtgcaggcg gtgtattttc ttcttttttg atatgggaca tataatagtg 1119961 aatcctgctg tccatttgtt ttctgatgtc ttcaataaca tgatgtctgt ttgtatcgtc 1120021 aagtctgctg tcatattgat tttcaagctg ttccaaaata tctgggattt cctcggttaa 1120081 gtacatgtcg acattctggc ggatctgctg catgagctga gcgctctctt cctgctgcat 1120141 catcccgatt tgcggtgtcg actggctgac gtcaaagttt tggacgctgt tcgggtcagt 1120201 cggatttaaa ccgatattca aagtcccgtc gagcctttcg attttcagct gatcaaattt 1120261 atactccaca cgctcaatgg tagtggccgg ccgctgtttc atcgtattca tttcagtttg 1120321 aatctctttc agctgacgtt cgagctgctg aatgtgaatc gcctgctgct gaacgaagga 1120381 attcaagttt tgcaggtaag aggaaacaga ttgatcatac atgttcttca cctctttcat 1120441 atgattaacg gccaggaggc tggagcggga ccaatgaacc tgtgtcgggc tcctgcagct 1120501 ggagcggttg ccctgagcca gaaacttctg gtgccggctc tacatagctt cctgtattat 1120561 acaaatttga cagtgacttg attgatccgg cgctcccgat ttgcagaatg gaggagttgc 1120621 tgattgattc cagccggaga tagttgattt gaatggtttg attaatatag aagttcatga 1120681 gcctcactcc ttttacgcat tggccacgat cggctgatca accgcatcat tgtcatacac 1120741 attcgtcgcg ttttgataat tcatcacctt gaggctgtcg ccggtattaa agctgccagc 1120801 accggcaaac gttctgacct gagcctgagg agaaatcgta atgcagtccc cgatgtgaac 1120861 gactccgctc gtaccaatcg cattaatttt aaacgctccg acaatggccg gcatacgagc 1120921 acatcctttg ttgaaaaatt aaaaaaagac aggtaaagtg aaatgacaat tccgatttca 1120981 attgggctat tcacgatagc ttatgacaaa cgcacatatg tgtgagagaa attttaaggg 1121041 gacatatcgg ctctttgtga aagcgtttta ttttttcggg ccgttatgtt taaacatggc 1121101 aaaagaggat gttgggtata aattgagcgg aaatgcggcg aaggatgccg ctatccgcct 1121161 atggtgattt ttgtttattt ctttggtgtt tttgcgtgta gaatgctttt tggagtatgt 1121221 cgtgctgcgg tattcgattt ttgggcgggc acattctcgc cctgaggtat atctcagaag 1121281 tgctgagcaa aaatcggagt taaatgtggt gtattctaat tgttatagaa aatgatttac 1121341 atacgggagt tttcaagata tctcccaaaa atcatttctt ctttaatccg ggtattcagc 1121401 aggatatcca gctcttggct gcattgaatc gtttcttttg aattcatgcc gtatttttgt 1121461 gcggtttcaa ttagtgtgat cctcatttct tcaattttac tgttcattac gctatctcca 1121521 attctagatt ttattttgat ataaatacag gatatcgtta gtataaccta ttttggctca 1121581 aaaggttgcc tttcgtcaat ttgactaaaa aagcgacaat ttttgctgcg gcctttttta 1121641 atggagaaag gactaaagtc ttgctaagtg tgcttgcaaa aagtcctgcc gttcctcaat 1121701 ttctctaagt atgttggtct gctccttttc gatttgaaag gggctttttt tgataaaagg 1121761 atcatcagca gcactttgac aaatgtcaag gtgccattcg ttgatgagag gagataatcg 1121821 ttcaatagta aacgaccgct tcagcacgtt tttcattaag gtgtgatatt gcgacctgaa 1121881 ggcgggaatg gatagaagcc ttgacgaaag cgtctttcct tttgtcagaa gcgggtcttc 1121941 ttcataccat tcttgtacgg caagcgatct tgtctccatc ggggaaacgt aaagccgacc 1122001 ggattcgttt aaacaaaatg tgtagtaaaa gccttgattg gtgcaggtgt tgccgatcag 1122061 ccacaaaaaa aacagcttga catccagata caatttaatc ctttcagcca attcgtcatc 1122121 tccggctgtg cggatcagta tgaaaaattc atgtaagaat gccgaggaat cattgttaaa 1122181 aagggacaat ggaacccttg gatcggccgt cttcactccg taactccttt taccggctgg 1122241 ctgatggttc ttgatgttca aataaatgcc ttcaggctgg ccattgatgg tcagaaagct 1122301 gtacgaggca acgggagcag gtacgccgat ctggtcaaaa aaacaatagg cgagtctgcg 1122361 ccgcatcagg gacggatcat cctgttctgc attcaaaaaa agtgtccttt caccaagcag 1122421 agacttttcc cagctgattt cataggatgc cttttccgct ctgtcacgct gtgtgagaag 1122481 aatgggagaa acagatcgat ctgttacgaa aagccccttg gctgtacctt tccttttcag 1122541 ctgctcccga tgaaaaaata aatgcacgcg ctccatattc tttcctcctt ctcaaaacga 1122601 catttgtatg atatgtagag caagcccgtc ctgaaacgaa atgaaaacgg aattgagaaa 1122661 aagggatttc agcattcgac agagaataca tgaaggagca ttctgattta aaagatgatg 1122721 gaggaataac atgaaatttg cgacagggga actttacaac cgaatgtttg tcggcctgat 1122781 cattgacgat gagaaaatta tggatttgca gaaggctgaa aaaaaactgt ttgaacttga 1122841 gacgattccg ggatcgctga ttgaatgtat cgcagaaggg gataaattcg ttgcgcatgc 1122901 aaggcagctg gccgagtggg caaagaaacc gaatgatgag ctgggatcat ttatgtattc 1122961 attatctgag gtgaagctcc atgcacccat tccgaagcca tcaaaaaata tcatctgcat 1123021 cggcaaaaac taccgggatc acgcgattga aatggggagc gaggctgata ttccggagca 1123081 tccgatggta tttacaaaat cgccggtaac ggttacgggg catggtgata tcgtaaagag 1123141 ccatgaagag gttacctctc agcttgatta tgagggagaa cttgctgtcg tgatcggaaa 1123201 aagcgggact cgcatttcaa aagaagatgc atatgaccat gttttcggat atacgattgt 1123261 gaatgatatc acggcgcgtg atctgcaaaa aaggcataag cagtttttta tcggaaaaag 1123321 cttggatacg acatgtccga tggggcccgt gcttgtacat aaatcatcta ttcaggagcc 1123381 agagcgcctc aaggttgaaa caagagtcaa cggcgagctg cgccaatccg gttcggcaag 1123441 cgatatgatc ttttccattc cggaattaat tgaaaccctc tcaaagggga tgacgcttga 1123501 agcgggcgac attattgcca ccggtacgcc gtctggtgtc ggcaaggggt ttacgcctcc 1123561 aaaattcttg cggtcaggtg acaaaattga tattacaatt gatccgatcg gaacgctgtc 1123621 aaaccaaatt ggctgaataa aactggaggg cggacccgga cccgcccgtt ttttctgata 1123681 atcatctttg tgacagagga caagttcatg gtactataag tggggtaatt tatctgatag 1123741 ggggaacata tatgacacac ctacatatta cgacatgggt ggtagcgctg attctgcttt 1123801 tcgtcagcta ctcgctgtat tcgtcaggaa gtgcaaaggg cgcaaaaatc actcatatga 1123861 ttctgcggtt attctatatc cttattattt tgacaggagc tgagctgttt gtccgtttcg 1123921 ccaactggaa cggagaatac gccggcaaaa tgattctggg cattatcacc atcggcctga 1123981 tggaaatgct cctcatccgc aagaaaaaag aaaaatcaac aggaggcctg tgggtcggct 1124041 tcgtcattgt ccttttgctg acagtgctgc tcggtctgca tttgccaatt ggttttcaat 1124101 tgttttaata gaaaaaccta tgaacccggc tctttgatag agctggtttt ttttatattt 1124161 atcccctcat attccaaatc atttaaaata accttaaaat tccctgtaag cggtatctcg 1124221 tcctatgaaa ttatgatacc ttcaaggaga ttcattattt tgcaggaggg ataacatgaa 1124281 acgcagaaaa ttcagctcgg ttgtggcggc agtgcttatt tttgcactga ttttcagcct 1124341 tttttctccg ggaaccaaag ctgcagcggc cggcgcgatc gatcaggcgg ctgctctgga 1124401 aaacggcaaa gagcagacag gcgccatgaa ggagccggaa caggtgaaat ggtacaaagt 1124461 gaccccggga gcaacggata ttcagaaaaa ctcacatatg gcactgaccg taaagagtga 1124521 ttcagtactg aatgtatctg tatatccaag taaggaaaaa gcgcttaaag atgagacgtt 1124581 tgagatgtac cgttctttca cagcggagga tggaaaaagc gaagtcattt ttccatacgc 1124641 gtggagcggc ccttactatg taaaagttga atacctcgga gaagaagaac cagaggacgg 1124701 cggaacggca gaagcagctg cagaagccaa gtatacgatt gggtataaag gcaccaaaaa 1124761 acagccgtca gatttagaag aggaagaagc ttgtccggtt gaaatgagtg tcgatcagaa 1124821 gaaatcagga aaaggcatcc tggataagtt gagatcgatt cgtgatgagc agctgagcca 1124881 aacagcagaa ggcaaagaac tgacaagcct ttattacaaa gcagcaccgt ttatcgttgc 1124941 aaagctcgca ctcaataaaa cagcaagaaa tgaaatctat caggatcttg tgacattaaa 1125001 gccgttattt gacgatgtgt cagaaaacgg agcatcatct tcgtataagg tcactgaaaa 1125061 ggatcaaaaa gcgatcaacc ggctatatga taaagcttta caatcagtcc cgtcattcct 1125121 taaagaggag ataaagaaac aagcggaccg actaaatatg aagcagctgc aaggcaaaac 1125181 agcaggagcc attttaacag aaaacaatat tgcagcaaaa agtgaagttc agacaacaaa 1125241 ggttattttc aaggtgaagg acaataaaag cctctcatcc gtacataatg aaatgaaggg 1125301 cttttctgca agcgcgcaat cgaaaaaaga catatctaat gtgaaaaagg caaagaaact 1125361 gtttgacaat ctgtattcat ttgaacttcc gaaagacgag aaacagaacg gcgcatatac 1125421 ggcaagcgcc aaaagggtca aaagcgctgc tgcgacacta tccaagatgt ccaatgtaga 1125481 gtttgcggaa cccgtacagg aatacaaaag cttggcaaac gatattcagt acccttatca 1125541 atggccgctt aaaaacaacg gtgaaaacgg cggtgtcaaa aatgcggatg tgaaatatga 1125601 gcctgccaac acattgctgt ccaaacgcaa gcttaacgat acactcattg cagtagtaga 1125661 cacaggcgta gacagcacgc ttgccgattt aaaaggaaaa gtaagaacag atctcggaca 1125721 caattttgtc ggacgaaata acaatgcaat ggatgatcag gggcatggga cgcatgtcgc 1125781 aggcattatt gcagcccaaa gcgataacgg ctattcaatg actggattga atgccaaagc 1125841 aaaaatcatc cctgtaaaag tgcttgattc cgcaggttcc ggagatactg aacaaattgc 1125901 tctcggcatc aaatatgctg ctgacaaagg agcaaaggtg attaatttaa gtttaggcgg 1125961 aggctacagc cgcgtgcttg aatttgcttt gaagtacgca gctgacaaaa atgtcttgat 1126021 tgccgcagcc agcgggaatg atggagaaaa tgccttatct tatcctgcat cttctaaata 1126081 tgtgatgtca gtcggcgcaa cgaatcgcat ggatatgacc gctgatttct ctaactatgg 1126141 aaaaggtctg gacatctctg ctccagggtc tgatatcccg agcttagtgc cgaacggaaa 1126201 tgtcacgtac atgagcggaa cgtctatggc gacgccatat gctgccgccg ctgcgggact 1126261 gctgtttgct caaaatccta agctaaaaag aacagaagtt gaggatatgt tgaaaaagac 1126321 ggcagatgat atttcctttg aaagtgtcga tggcggagaa gaagagttgt atgacgatta 1126381 tggcgatccg attgaaattc cgaagacacc tggtgtagac tggcattcag gctacgggcg 1126441 gctgaatgtc atgaaggctg tcagcgcagc tgatttacag cttaaggtca acaagctgga 1126501 aagcactcaa acagctgtca gaggaagcgc gaaggaaggc acccttatcg aggtgatgaa 1126561 cggcaaaaag aaactcggca gcgccaaagc cggaaaagac aatgcgttca aggtgaatat 1126621 cgcgactcaa aaacaggatc aagtactgta tctgaaagca acaaaaggcg atgcgaaaac 1126681 atcgtataaa gttgttgtcg tcaaaggaaa accttccggc acaccgaaag taaacgcggt 1126741 gaaaacgaag gatacggcag taaaagggaa ggcaaacagc aaagcgatga tcagagtgaa 1126801 aaacaaatca aagaaagtca ttgcttctgc caaagctgac gcaaaaggaa cgttttcggt 1126861 gaaaatcaaa aaacaaaaag ccggaacggt gctgtacgtc acggctgtgg atacagataa 1126921 aaaagaaagc aaggaagcaa aagttgttgt tgaaaagtaa ccaaaaagcg gtgctcgatg 1126981 caccgctttt ttatttgcgc ccccgttgga ctgctgtgta cataatggat cgctttccgt 1127041 ttgaagccgt ccattcaaaa cggtctcctg tcccttcgct gctgtagttg tagtgatgct 1127101 gcatcgcgca ttgtgcggtg tcatttgaaa agtgataaaa ggacacaccc tgccccgccg 1127161 aagtattcga aaagactcct ttattataag aaaagacgca atcgaatacc gataagccga 1127221 agctgtgcaa gtgctgcaga aatgcgagaa aggtttcgtc gtcaagcgaa tccaaaagcg 1127281 ccatgagcgg ccgcttgact gatttctcat agcggatgcg ttctccgccg gaaagggaga 1127341 tgttttctgc accgcatgcc aaaaccaact tgtcctgaaa gccggcttgc tcccactttc 1127401 ctttatgatg gatccagatt gggctgtgtt ggagactgtc cgccagcagt atatcgcctt 1127461 caccgttttc gattaagcag atgccgtctt caatgaggat ggtgccgtat tcccactttc 1127521 gttcctctgt atataacaat tgtttccgtt tcatccatgc tgtctccttt ttcttcattc 1127581 ctctcttttc tttccaattc aagcctgtcc catacaactc ttttatggac aaatcaacta 1127641 tctgcctata gatgcataaa cttactaagg tgctgaaaga aacgaaattg ttacgaaaga 1127701 aacgggattg gagctgatgt cacatgtgtg gaattacggg ttgggtcgat tttaaaaagc 1127761 agctcgtcca ggaaaaacaa acgatggaca gaatgacaga cactctttcc aaacgagggc 1127821 ctgatgattc aaacgtttgg ggggagcacc atgttttatt cggacataaa agacttgcgg 1127881 ttgttgatat tgaaggcgga cgccagccga tggcgtgtac ctataaaggc gatacgtaca 1127941 ccattattta caatggcgag ctttataaca cggaagattt gcgcaaagaa ttgcgggcgc 1128001 ggggccatca attcgagcgt acgtcagata ccgaggtgct tctgcacagc tacatcgagt 1128061 ggcaggaaga ctgtgtcgac catctcaatg gcatattcgc tttcgctgtg tgggatgaaa 1128121 agcgtaatct gttgtttgcc gcgagagacc gtctcggtgt aaagccgttt ttttacacga 1128181 aggaaggctc ttcatttctc ttcgggtcgg aaatcaaagc aatcctcgcg caccctgata 1128241 taaaagcgcg agtggacaga acgggacttt ctgaaatttt cggtcttgga ccgtccagaa 1128301 ccccgggcac tggcatattt aaaggcataa aagaaatccg cccggctcac gcgctgacat 1128361 tttccaaaga cggacttaat atttggcgtt attggaatgt tgaaagcgaa aaacatacgg 1128421 acagttttga tgacacggtt gccaatgtca gatcgttatt tcaggacgcg gtgacgcggc 1128481 agcttgtgtc ggatgtgcct gtttgcacat tcctatcagg cggtctggac tcaagcgcga 1128541 ttacagcgat tgcggcgggc cattttgaaa aggaaggaaa agcaccgctt catacttatt 1128601 cgattgatta cgaagagaac gataaatatt ttcaagcaag cgcttttcag ccgaatgatg 1128661 acggaccatg gattgaaaaa atgacagagg ctttcggcac aacgcaccac aaatgcgtca 1128721 tcagccaaaa agacctcgtt gatcatttgg aggaagctgt actggtcaaa gacttgccgg 1128781 gaatggcaga tgtcgactca tccctgctgt ggttttgccg ggaaatcaaa aaggactttg 1128841 tcgtcagcct atcgggagaa tgcgcggatg agattttcgg cgggtacccg tggttccata 1128901 cggcagatgt tgagtctggc tttccatgga tgagatcaac ggaggagcgg atcaagctgc 1128961 tttctgactc atggcagaaa aaattgaatc tgaaagaata cgtaaatgcc aaatatgaag 1129021 aaaccttggc agaaacgcca ttattagacg gagaaacggg tgtggataaa gcaagaagac 1129081 agctgttcta tttaaatatg ctttggttta tgacgaacct tttggatcgg aaggatcgca 1129141 tgagcatggg ggcgagcctg gaagtgcggg tgccgttcgc cgatcaccgg cttgtggaat 1129201 atgtttggaa tattccgtgg gaaatgaaaa tgcatgataa tcgggaaaaa ggcattttgc 1129261 gcaaagcgct tgagggcatt ttgcctgatg acattttgta tcgcaaaaaa agcccatatc 1129321 cgaaaacaca tcatccggaa tatacaaaag gcgtcagcga gtggctgaaa acgatcagaa 1129381 gccaaaagga ctccgtgctc cataccttac tggacagaaa acaattagat cagcttttag 1129441 aaacggaagg ctcctccttc aaggtcccgt ggttcgggca gctcatgaag gggcctcagc 1129501 tgatcgccca tcttgctcaa attcatacat ggtttgaagc gtatcgcatt gatattgacg 1129561 agaggtaggt tcaatacaaa tgtgattaaa agccagagat gtatagattt aaataagaag 1129621 gatagatgag cagggaaata tatgctctat ctatcctttt ttgtacaaca gcactatcga 1129681 attgcccccg cattccttca ataagaatga ataggtttta atgttctgcc gataaaacta 1129741 gctgataccg ggcttaactt taattcccta gcccatacag aaagttgacc aatatggtga 1129801 atttcgtgag cgatgatatg gtgtaatatt tcatctcgcg tatataaaac acctgtctcc 1129861 caaggaacgc ttacaagttc atcttttatt tgatctgaat gtgtttgtaa aacatcaatt 1129921 atttcagttc ggaatgtatt tgagagagat ttcactttat tgagtgtttg ataatcagcg 1129981 aactgaacag cgatatcttc ttttccttgg atagcacgaa tccaactata ttccacatca 1130041 ataatatgaa aaagggtata taaaatattc tctactccgc caagacgatt tttaagtaat 1130101 tcttcagtgg ttagttgatg acaccaagta aaccattgat ctctaacctg ccagttatat 1130161 tcaaaaaatt tcatcactaa actcactcca atactatcat gtatcataac aattagccct 1130221 tttttccgtg attcctctat taatgaagtg atgattgaga aatgtttaca ttctacctgt 1130281 tgtatggcat taaaaataat aatgcatatc tcgtcgatga tgctgtgcgt cttgttactt 1130341 ttacaaagta agaatcggca ttttcttcat atacaattag gaaaaaacat actagacttg 1130401 aagaagcagt gatacatagg agtgagaaaa tgaaagagat aaaagaagct taccagcaat 1130461 gcggacagat tgttggcgaa tacgcgccag cctgtttcaa agcattatca tatctcccgc 1130521 taaagcaaag acaagcctct tgggcagtat tgtcgttttg ccacacggcg gccagtgcag 1130581 acgaaaaggt attgcccgca tttgaagcta aagctgatca tgtttaccaa aggacaaata 1130641 acggtaaaca acatctatgg aaggcttttg atcatgcgta tcggaccttt acattggaaa 1130701 gcgaaccttt tcgggagttt attgccgcac aaaaagaaga cgccaagccg tatgatgacc 1130761 ttgatgaact gctcatgtac gcatatcgga cgggcggtgc tgccggattg atgctgctgc 1130821 cgatactgac acgccgaaaa caagatcagc tcaaacaagc agccgtctct ctcggcttgg 1130881 ccatacagct ggttcgcttc ttaagtgatc ttggcacaga tcagcaaaaa aaccgcattc 1130941 cccgtcaggt aatgcagcaa ttcggctata cagaggctga tctccaaaaa ggcaccgtaa 1131001 ataaagcgtt cacaatgacg tgggagtata tcgcttttga agcagaagcc taccttgaag 1131061 agtgtcagga tgccttgccg ctatttccgc agtattctca aaaaacggtg aaagccgctc 1131121 ttcatttgca ccgggctgtt ttagaaaaaa tccgggcgaa gcagcacgat gtatttcaat 1131181 atcacttcgc tctcacagag accgaagtga agcagattct gtctgatatc taaaaaacac 1131241 ccggccttga ttgagccggg tgttacgcca tacctttttg aatccagata cgtgagcgcc 1131301 atcttctgta cattaagatt ccccggaccc attcatccgc gataaaagaa atccaaatgc 1131361 cggcaagacc gaaaccgagg tggatgccga aaagataagc aagcgggagg ccaatgcccc 1131421 acattgaaat cattgccatg taaaccggga atttcgcatc ccccgcggcc cgcagagagt 1131481 taatgataat gacattaaac gagcggcctg gttcaaggat aatggtcatg gcaatcaata 1131541 ggcttgcagt tgctataatg tcagggcttt gtgtgaagag tccgatcagg tcttttgaaa 1131601 agatcgtcat caaaacagag gtagccgcag caattccgag tgcccaatat aagctcttca 1131661 tgcagcgctc ataagcggca tcaaattgtt tgccgccgat ataacggccg attaagattt 1131721 gtgtaccctg gctgatcgca gtgccgaaca gcaaaataaa catcgtaata ttttgcgtat 1131781 acacttttgt tgtcaacgcc tgcgcgccca tgatggcgat aaaatacgtg actatcattt 1131841 gcgacaggtt gtatgaaagc tgctctcccg cagaaggaat gccgattttc agcagcttgc 1131901 gcaaatgctc tttatgcata tgaaagactt ttttcagcga catcttcagc tggatgcgtt 1131961 tgttgacaat cacaatcatc gcgattaatc cgatgacgcg ggcgatagat gtggacatgg 1132021 ccacaccggc aacaccgaga acaggaaagc cgaacaaacc gaaaatcaca acaaagtttc 1132081 cggcaatgtt taaaatgttc atgccgatag tgacaaacat tgtatctttt gtgtagccgt 1132141 agctttttaa gatcgcgctg aatgtcatga ttaaagcctg aataaaggac agacctccga 1132201 caacttgtaa aaagactttc gcatcaggca tcagtgcgtc tgataatccc atcatatgaa 1132261 gcagagggac agccgcgaaa aagacgacgg cgctgatggc caggctgatg aagaagttgg 1132321 cgccgattga cacataagcg acttccatgg cttctttctt ttgccgtgag cctagaaatt 1132381 gtgaaatgat aacggtcgtt cctgttgcga taaagctgaa catcacgata attaaattta 1132441 aaatctggtt gctgacgccg actgctgcca cgctgttatc cgagtattgg ctgagcatca 1132501 gtgtatcggc attacccata aacatatata atgagacctc aataaagatc ggccaagtaa 1132561 gcgaaaataa tgagaacgtt ttgtcagcgg gttttttcaa agcagttgat ttgaagacag 1132621 cttgtttcat cgtgtctaac ccctttcgta aataaaatca acgttttaaa gtgtacctcc 1132681 atttccttat aataaaaagg gatagaaacg atacttcttg taaaaatccg acttaaaaag 1132741 gaggatgatt caaatgcctc gcatcctgtt tacagtcccg ccttttccgg tatttatcgc 1132801 agctggggaa ggggttttta aaaaaggaga aacccatgtg aaacgtgtat tctccgtgtt 1132861 tgatctgata tatgtcaaac agggaacgtt atatataacg gaaaatgaaa catcgttttc 1132921 tgttgaaggc ggcgagtaca tcttgctttc tcccggtctt gaacactacg ggacgaaggg 1132981 cagtgatgaa gcaacctcct actattggct tcacttcgat gaacatcgat atgaatttac 1133041 ggcaaaggga ggcagcaact ggtctgagct tcagcaggaa aaagggagct tcgaagagct 1133101 ggcccgctac ggattggcct tgccgagaaa aggcaaggtg cagcgcccgc agtttatggc 1133161 gcagcagttt gaaaagctga tcgattactc cgcggaaaac tctgatttgc cgctcagaaa 1133221 gcaaatttta tttgaggagc tgatgctgca tcttcaaaaa gaagcgttcc aaataccgtc 1133281 tgcgaaagag cgggtagcct gggaggcggc ccggtattta caggagcact ataaggaaaa 1133341 gacgacaatc aaggatctgt cgctcgccct tcactatcat caggattatg tgagccgctg 1133401 catgcagcag gtgctcggcg taactccggc acaatacacg aaccgggtga gaatgacgga 1133461 agcgaagcgt cttttatcct ctacaaatga taaaatgggc gttattgcgg aaacggtcgg 1133521 aatggaagat ccgacatact tttcaaaact ctttaagcag atagaaggca tttcaccaat 1133581 tgaataccgg aaaattgtca gccggaaagt tcaataacca gacgagggat gaacatgaaa 1133641 acaacaattt acgatgtggc aaaggcggcg ggtgtttcga tcacaactgt gtcccgtgtg 1133701 ataaacaata cggggagaat cagcgataaa acacggcaga aggtcatgaa tgtcatgaat 1133761 gaaatggcat acacgcccaa tgtccacgcc gcggcgttaa cgggaaaacg aacgaatatg 1133821 atcgctctcg tggcgcctga tatttcaaat ccgttttacg gcgaactggc caaaagcatt 1133881 gaggaaagag cggatgagct cggttttcaa atgttgattt gcagcaccga ttacgatccg 1133941 aaaaaagaaa caaagtattt ttctgtgctg aaacagaaaa aggtggatgg cattattttt 1134001 gcaacaggga ttgaaagcca tgacagtatg tctgctttgg aggaaatcgc cagtgaacaa 1134061 attccgattg ccatgatttc tcaggataag ccgcttcttc cgatggatat tgttgtgata 1134121 gacgacgttc gtggcggata tgaggctgcc aagcatcttc tgtcactcgg ccacacgaac 1134181 atcgcctgca ttatcggaga cgggtcaacg acaggcgaaa aaaatagaat caaaggcttc 1134241 cgtcaggcga tggaggaagc gggcgtgccc attgatgaat cacttatcat ccagacgcgg 1134301 ttttccttgg aaagcggcaa ggaagaagcg ggaaaattgc tcgacagaaa tgctccgact 1134361 gctatttttg ccttcaacga cgtattggct tgtgccgcca tacaagctgc gagaataaga 1134421 ggcataaaag tgccggatga tctttctatc attggttttg ataatacgat actcgcagaa 1134481 atggcggctc cgcccctgac aaccgtagcc cagccgataa aagagatggg gcggagcgtc 1134541 atcgaactgc tggcagaagc aatagaggga aaacgaaagg cgaaacaaaa aatagtgctc 1134601 ccgcctgagc ttgtagtcag acattctaca tcaccgctca acacatgagc ccgctaatga 1134661 gcgggttttt tcattatgac agttgaagcc aaaaaaacat attgcgtgta aaccaaaggc 1134721 ggtgtaaaat ataaccatct tttgagaaag cgcttgcgca aaatggcaga gcggatagaa 1134781 ccgctgtttt tttagctgtt aagagaaaac gctttctcaa agcgagcccg aaatgagata 1134841 aaggagagga tgggacgtgg aacatcaagt aagatgtgca gtattgggat taggaaggct 1134901 cggttattat catgcgaaaa atctcgtcac cagtgtgccg ggggcaaagc tggtttgtgt 1134961 cggtgatccg ttaaaaggga gagcggagca ggttgccaga gaactcggta tcgaaaaatg 1135021 gtcagaggac ccgtatgaag tgttagaaga tcccggcatt gatgctgtca ttatcgtaac 1135081 gccgacaagc acacatggtg atatgatcat caaagcagcc gagaacggca aacagatctt 1135141 tgttgaaaaa ccgctgacat taagccttga ggaatcaaaa gcagcttctg aaaaagttaa 1135201 ggagacaggt gtcatctgcc aagtcggctt tatgagacgg ttcgatcccg catacgcaga 1135261 tgccaaacgg cggatcgacg ctggagaaat cggcaaacct atctattata aaggctttac 1135321 gcgcgaccaa ggcgcgcctc ccgcagaatt tatcaaacac agcggtggaa tttttatcga 1135381 ctgttccatc catgactatg atattgcccg ttatttgcta ggggcggaaa tcacttctgt 1135441 ttcaggacac ggcaggattc tgaacaatcc gtttatggag cagtatggcg atgtggatca 1135501 ggcgctgacg tatattgaat ttgactcggg cgcagcgggg gacgtcgagg caagcagaac 1135561 ctctccatac ggacatgaca tccgggcgga ggtgatcggg acagagggca gtattttcat 1135621 agggacattg agacatcaac atgtgaccat cctatcggct aaagggagca gttttgatat 1135681 cattccagac tttcaaactc gttttcatga agcctactgc ttggagcttc agcatttcgc 1135741 cgagtgtgtc cggaatggaa aaacaccgat tgtgactgat attgatgcga cgatcaattt 1135801 agaagtgggt atcgccgcaa ccaattcctt tcgaaacggc atgccggtac agctagatgt 1135861 gaagcgcgct tatacaggta tgtaaaagct aagtatgttg catttgaggc tttccgcaaa 1135921 aaaagcaagg gcattttagc ccttgctttc tcttttctca tataaatagt acatataatc 1135981 agtaggtacg cctgaatggt ccagctgtct cagcatggcg gttacgttcc ctctgtggta 1136041 agtgccgtga ttgacgacat gcaggatggt gtctgcatag gttgattcca gtgtacctag 1136101 tttcggatgc tgcattgtga aggtctgttc taagtccgtc tggcggctga agaaatcatg 1136161 atactgtgac tccagctcgg cagcgtgctg tttaatcgct gccatattac cttgcgcgga 1136221 ctgtaatttg cctgcgctgt ctataatctc ttggtaggcc actcccgaaa gaacattcag 1136281 ccaaatgtag tcagccctgc acatatgaag cagcacgtcg ctgacagaag gaaatacgct 1136341 ctttacttct tgataggcag tttcctccgg caggttttcg atatgggtaa atattttctt 1136401 gtttgcccaa gaatgatagt cataaaactg ttttgcatca gtcatcagca tgcccccttt 1136461 tctaagaaat tcgttttttt catctgtttc tccttcaatt gcaaaagagt gacaccccaa 1136521 aatatcctgc cgctgcccac attaccgctg cagagcattt gtttacgatc agcataagcc 1136581 tgccgctcgt atctatcgtc tgaaacaacc ggcccgctat tgcaaggctg atgaaccaaa 1136641 tccaagacac agcgatgcag gcggccataa agagccattt ctcaagcccc gaatattgaa 1136701 gagagctcgt gccgatgacg ccgatcgtgt ccagaatggc atgcgggttt aaaagagaaa 1136761 cagcggccgc aaacgcagct tgcttttttg gtgtgaacgt atgtttctca ttttggcttg 1136821 tgttcggacg gatgttccaa gtcacccagc ccatataaag caaaaataaa aatccgccgg 1136881 ccatcatgac tgtctcaaac acaggcagct cctgcacaat gacagacacg cccgcaacgg 1136941 ctaatacaat taacaaggta tcgcagactg aagcactgat gacagctggg agagcccgcc 1137001 aaatatgctt ttgcaacgcg ccttgctgaa aaataaacac attctgcact cccagcggca 1137061 aaattaagcc aaacgcgagc acaattccgt gaatgattgc attcatgctg aaaaagctcc 1137121 tttcacattt tttttcaatc ataagagaga ttgtcactaa agtctccagc catttggttg 1137181 ggttaggaac cagccaaatg tataatgtgt aaaaaagggg ggcatgacct tgtcgcaatg 1137241 gcagccaagc cgaaagtcgg atgttccgct gcatcggcag atcgaacaat atatgaaaga 1137301 caagattctt cacggagagt gggctgtagg gacgaaaatc ccctcacaga gaacgctggc 1137361 cgacatgttt caagtcaacc gcagcacagt cacagcagcc atagatgaac tcacgtctca 1137421 aggcttgtta gagggaagaa aaggcggcgg tacgaaggtt gtaaacagta cttggagcgt 1137481 gctgacggct gagcctccgc ttgattggag cgattacgtc cgttcgggca ttcatcgcgc 1137541 caattcttcc atcattcaag ctattaatca gaacgaacca agagcggata tcatcagatt 1137601 aggaactgga gaactttcac cggatcttgt gcctgctgac acaattggac ggatgtttca 1137661 gcaaatcaat ccgggcgtcc tgtctttagg atatgagcag ccgaaaggaa accgtcagct 1137721 gcgggaggca gtggccgacc atttaaaagg aaagaagatc catgtgtcac cgtctgcaat 1137781 tttaattgtg tccggtgcac ttcaggcact tcagctcatc tcaattggac ttttaaaacg 1137841 agattctgtc attttgacgg agaagccgtc ctaccttcaa tccttgcatg tatttcaatc 1137901 agctgggatg cggcttcgcg gcttgccgat ggatgatgaa ggggtcaaag cggggcttgt 1137961 ttcttctaat cgaaaacaat atggaggaca gctgctttac acgattccgt cgtttcataa 1138021 tccgacaggc acagtcatgt cagagcagcg aaggaaagag atcatcagcc tgtcaaaaaa 1138081 agagcagatg cccatcattg aggatgatgc gtacggtgat ttatggtttg aagaaaaacc 1138141 gccgcagccg ttgaaagcaa tggatcatga gggcaatatt ctgtatctgg gcgcgttttc 1138201 aaaaacggtt agccccggtc tgcgaatcgg ctggcttgcc ggtccggagc cggttattga 1138261 aaggctggcg gacattaaaa tgcagacaga ctacggatca agcggcctgt cccagtgggc 1138321 ggctgccgag tggctgtcac agggatatta tgaagagcat ctgacttggg tacgcaggaa 1138381 gcttaaagaa aggagagacg ccgccgttca ttttctcgag cggtatgccg gggacattgc 1138441 cacgtggcgg attcccgcag gcggctttta tatttgggtg acatttcaca aaaacctgcc 1138501 tgtcagccgt ttcttttatg aattgctgaa acggcaggtg cttgtgaatc ccggctatat 1138561 ttatgacggt gaagaccgaa acagcatcag gctgtcatat tcctatgcat ctcttggaga 1138621 tttggaaact ggcattaaag cggcagctga aacagcacgc cgcctgatga tgtcctaggc 1138681 tttggttata cgatgacagc tcccagtgcc ctggcgaagg caatcgcgtg ctcaggtgcg 1138741 attttgcagc ctttcaattt gtcgagggag acatgaagct gttcaaaacg gcacgtgctg 1138801 atgtccatgt tttgaaggga cgtgccggta aagctggcgc cttccaattc gcatccgtca 1138861 aagtgtgtct gctggagcac cgtatcgctg cattcacttt gcataagagc acagtgatca 1138921 aatcgaactt gtttcatatt tgagtacgaa aatgagctga aatgtccgtg gcattcctcg 1138981 aatgaaacat tccgcagcgt tgcttccgcc acattcattc caaccatttt tgactgctta 1139041 actgaagttc tgtgaatgac agccccgctg aaatcggcgt ttgataaatc gcatttttca 1139101 aagatcacat cggtcagttc aatatgccga aaagacacat cgataaagac gacatttctg 1139161 aataccgttt tttcaacaca tagtctttcg atatcttcgc cgcagatggt gcaatcttca 1139221 aacaaatgca tgctgattac atcatcctgt gtcacggcat catgaaaatc tgcggtttgc 1139281 aggttttccg gtatgttcgg tttttgaatt gcgattttat tcatgtgatg acatcctttg 1139341 ctgcccgaaa aacagaggct tccgggttca atttaataga tcgttaagga aattgataca 1139401 tatagtaaat cgtgaagagc cttttcttgg tacagcagcc cgcttgtttt gtaagcataa 1139461 atggaaagct tcctatacgt caaggcgttt acaggccgaa aaagccaaag ggaacaggag 1139521 gaatgcggaa tggggcatta catcaaaacc gaggagcatg tgacactgtt tgtagaggat 1139581 atcggacatg gaaggccgat catctttttg cacgggtggc cgttgaatca taagatgttt 1139641 gaatatcaaa tgaatgagct tccgaaaagg ggatttcgtt ttatcggcgt tgatttgcgg 1139701 ggatatgggc aatctgaccg cccttgggaa ggctacgatt atgacacgat ggccgatgat 1139761 gtgaaagcag tcatttatac gctgcagctt gagaatgcga ttcttgccgg tttttcaatg 1139821 ggcggcgcaa ttgcaatccg ttatatggca aggcatgaag gagccgatgt tgataagctg 1139881 attttactgt ctgcggcggc ccccgcgttt acaaaacgcc cgggttatcc gtacgggatg 1139941 aggaagcagg atattgacga tatgattgaa ttgttcaaag ctgatcggcc caaaacactg 1140001 gctgatttag ggaaacagtt ttttgagaaa aaagtgtctc cagagcttag gcagtggttt 1140061 ctcaatctga tgctggaggc ttcctcctac gggacgatcc actcgggcat cgcattaaga 1140121 gacgaagatc tcagaaagga acttgctgca atcaaggtgc cgacgctgat cctgcacggg 1140181 agaaaggata gaattgcgcc gtttgatttt gcgaaagaat tgaagcgcgg catcaaacag 1140241 tcggaattgg ttccgtttgc aaacagcggg cacggagcat tttatgagga aaaagagaag 1140301 atcaacagtt tgattgcgca gttctccaac tcataagaaa aaacccgaca ttgatcgggt 1140361 tttttatata attcctctgt tttgcagtgc gttaatgatg agatcagctc catcggaaat 1140421 agaggtctgg tcagactcaa tgatgaaatc gggtgaaagc ggcgcttcat acggagaatc 1140481 gatcccggtg aaatgtttga tctctccgtt tcgcgctttt ttataaagcc cttttggatc 1140541 gcgctgttca caaacatgca gcgggcactt cacataaatt tcgaagaact cacctttagg 1140601 aaagagcgct ctaaccatgt cccgatcctc tctgaatgga gaaataaaag ccgttaaaat 1140661 catttgcccg ctgtcgacaa acagcttcgc cacttctccg atccggcgga tgttttcaat 1140721 cctgtcacca gtctgaaatc caagatcttt gtttaagccg tggcggatat tatcaccgtc 1140781 aagcacgtag ctctgaatgc ccttgcggta aagcttttca tcgacagcat tggccagcac 1140841 cgattttccg gagccggaca aacctgtaaa ccaaaggacg cagcttttgt gtccgtttaa 1140901 ggactgtctg tcagactttg agatggcagc gggatgccaa atgatgttcg gattgtgtgt 1140961 cattgcaatt ccccgctgtt ttgcttgatg gcaacaggct gttggtgaag tcccttgatc 1141021 agcacggctg cgacctcagg ccggctgaat tctttaggcg gctttttgcc ttggcggaga 1141081 agctctctca cttttgtgcc tgataagtgg atgtggtctc tcgggctgtg cggacatgtt 1141141 ttggaggtgc ccatgtttcc gcattttcgg caataaaagc tgtgctcaaa aaacagcggc 1141201 ttgatgccca gctcttcctc tgtgaatgat tgaaaaatat tttgggcgtc gtatgttcca 1141261 tagtagctgc cgacacccgc gtgatcacgg cctacaataa aatgggtaca gccgtaattt 1141321 tttcggacga gcgcatggaa aatcgcttcc cgcggacctg cataacgcat ggcggcaggg 1141381 aaaaccgata acatgacacg atcctttgga taatagtgat taagcaaagc ctggtagctc 1141441 tccattctga tatcgctggg gatatcgtct gactttgttt ctccgacaag tgggtgaagc 1141501 agcagaccgt cgaccgtttc taacgctgtt ttttgaatgt attcatgcgc tctgtgaaca 1141561 gggttcctgg tttgaaagcc gacaatcgtc ttccagccga gtttttgaaa ggccgctctt 1141621 gtttcagcgg gcgttgcata aaactgttcg aaagatttgt caggcaggct gctgaccgtg 1141681 ataggccctc cgatatagta atccgggcgc gccagcaatt tttttacgcc tgggtgggca 1141741 ggatcgtttg ttttaaaaac agacagtgct tcttgtgttt tatcaggctg gtatatatcg 1141801 gtgactgtga tcatgccgta ggtaacaccg tctttcacaa gcttgacgtg atctccggca 1141861 gacagctgtc ttgctgtttt ttctccgaca ggcagcgtaa tcggcaggct ccacggcaag 1141921 ccgtttgcca gcctcatctc tttcacaacg gaatgataat ctttttctcc caaaaaacct 1141981 gttaacgggc tgtagccgcc gatcgcaata agctccagat cactcagtgc aagctgatcc 1142041 agctctgctt ggcacgcgca cccttcaaaa tggcatgcgg gatcacagcg gttgattaat 1142101 acccctccgt ggggttcgtt tccattcaac gtgttcaacc tccatttata cgtttccttg 1142161 ttttcttttc tgcacttaat gaaagtttga catcagcgcc ttaacatcat ttcgattctc 1142221 acatcaagaa cctgccatcc gctattcttg atgcaggccg cattctgttt tctcccgtcc 1142281 ggcccatctt ccagccctct catcgttcgg gtccggggaa ggcagtgtac acatttcaca 1142341 gcctatgctc ggataatgtt gatcgtgcag tttgttataa ggcaaattgt gcaggcggat 1142401 gtacgtccaa acgtcatccc atgtccagtg gataagcggg caaattttga tgagctcaaa 1142461 cttctggtcc aggtttacgt attgaatatg ctttctcgtt ggtgactgat cccggcgcag 1142521 tcctgaaatc caagctgtca tgccggacag gtgctttttg agcggttcga ttttccgcaa 1142581 ttggcagcag aggttcgggt tatgcttcca cagctctccg ccgtacttcg tcccctgttc 1142641 tgttaagctc agctcgggtt cgagcatctg gattgcaaat cccggatatc gttctttgac 1142701 ggtctcgatc agctcatatg tttcctgaaa atgaagcccg gtatccaaaa agatgatgtg 1142761 tgcgtttttg ttgatttttg atattaagtc gagaagcacc attccttctg cgccaaagct 1142821 gcaggcgtac acaatctttt ctccgtacgt tcggtaagcc catttcaaca catcgagctc 1142881 atcgatcaat tgatccgtta tctgtttgga cagcatgtcg ttccaagtgt catatgtgat 1142941 ggtttcgttc aatgttttcc ccccgtttgc atctgctttt tttatctatt gatcgagtta 1143001 taggcagact attcattttt tgcataaagg ttcaggtttt aggtgccgcg cccgcctaaa 1143061 atgaggtgcg gaaccattaa gagcccggct gaatatgctt tttagcaaaa tggttttatg 1143121 cccaaggaga ggtagtatgc cgattgccat ttatcagggg catcatcatt cgcttgcccc 1143181 ggcggacatt aacatcgtca ttgatgtcat cagagccttt acggtcgccc attatgcgtt 1143241 tatcggcggg gcgaaagaga ttttgttggt ccggacagct gatgaagcct ttgcgctgaa 1143301 agacacctat ccggattatg ttttgacggg agaggaaaag ggggtcggta tcagcggatt 1143361 tgatttagat aattctccaa aacgtatggc tgggcagaat atgacggata aaagcctgat 1143421 ccagaaaaca acaaacggcg tcacagcagc attgggggcg ctgaacgcaa agcatctgtt 1143481 cgtaactgga ttttccaatg ccaaaacaac ggcacagcat gtgaaaaagc tcgtcgcaaa 1143541 cgattgtgtc ataaacatag tggcttccca tccatccggt gatgacgata tggcatgtgc 1143601 ggagtatatc aaaggcatca ttgaagggac aaatgtggta acggctgcgg aggcgattga 1143661 aagaataaaa ggctcttctg ttgcggagaa gttttttgac tgccgccagc cattgtttga 1143721 ttcggaagac atcgtttact gtacaaaaga actgacgggc gatttcgtga tgaaagtgaa 1143781 acaagatgga gaagttccaa cgatagagag ggtcataata tgaatgattt ttcactagaa 1143841 ttgccagtga gaacaaacaa gccgagagaa accgggcagt ccattttaat tgataacggc 1143901 tatcccttgc aatttttcaa agatgcgata gccggagcgt ccgactatat tgattttgtg 1143961 aaattcggct ggggcacatc attacttacg aaagatcttg aagaaaaaat cagcacactg 1144021 aaagaacatg acattacatt tttctttggc ggcacactgt ttgaaaagta cgtaagccag 1144081 aaaaaagtga atgaatttca tcggtactgc acctatttcg gctgtgaata tattgagatt 1144141 tcaaacggta cgctcccgat gacaaataaa gagaaagcgg cttacattgc cgatttttct 1144201 gatgaatttc ttgtgctcag tgaggtgggc agcaaggatg cggaattagc aagccggcaa 1144261 agctctgagg aatggcttga atatatcgtt gaggatatgg aagcgggcgc ggaaaaagtg 1144321 attacagaag ccagagaaag cggaacggga gggatctgtt ccagcagcgg cgatgtcagg 1144381 tttcaaattg ttgacgacat catttcctcg gatattgata tcaacaggct gatttttgaa 1144441 gcgcctaaca aaacgcttca gcaagggttt attcaaaaaa tcgggccgaa tgtgaatctt 1144501 gccaatattc catttcatga tgccatcgcg ttggaaacgc tgcgtttagg gctaagatcc 1144561 gatacctttt ttctgtaaaa tagcggctgc ggggctctcg tcgtgaagag agcctctgcc 1144621 tattattttt tatggcggta cataggcgtg agatagggaa gtgaggtcag gcggatgttg 1144681 tagatgaagt cgatgactct tgtcgatatc acctggcata tgagggcttg aatgacgatg 1144741 ccccagtcaa taatagacgc ggtgaccata aaaatgatgc aattcatgat gagcaggatc 1144801 gttccaggat tcccgccgcg gtagatagaa atcatcagag caagggctcc gaatcctccg 1144861 ttcgaaattt tatatttgta taaaagtccg attccgagtc ccaataacac tgcgccgctt 1144921 gccagatcaa gccacaggtt agatgtgata tcaggaaaaa ctgcatcaaa gatcaatacc 1144981 gagacagagg tgacggtgat agaagcgagg gtgccggtga atgttctcat ctccagccat 1145041 tttaaagcgg taaaaagcat tgatacattc acagcccaca ctgaaaatcc gtgggggatt 1145101 tgaaacagat aatgcaatag caccgcaata cctgctgcac cgcctgtcgg aatatcatgc 1145161 ggaaataaaa acaaggacat gccgagtcct tgtagtacgc cgcctacgac aatcataaac 1145221 gtaagttttg ctttcatcag cagttcagcc attaagtcat ttgctccttt atgaaaagac 1145281 ttgtccgctg ttttcatttt atgaggctgt ccattattta tgtctcaaaa taaagaaatg 1145341 gcccagctta ataggctgag ccatcccact tgtagcgatt gacgatctcc atattgatct 1145401 ctgtgccaat gccttttcct ttcgggatgt ggaccattcc ttttgaaggc tgcaggctga 1145461 cgagatctgt aaaaggattc tccatgacgt cccactcgat cggttcaatg tgatcgttct 1145521 tcattttaga ccatgggggc agacaggctt gtgcaaataa agcatagagc cgtgagagcg 1145581 atccgtcata tgcatgggcg gatgctctga cgccgaaata acgcgcgagc tggaggcagt 1145641 cccgaaactc atcaattccg ttgacatgca tgacatcggg ctgaatgata tccaaacagc 1145701 gctgtgaaag gagaggcaca tattgcgccg ggcctttcat gttttctccg ccggcaacag 1145761 gaacagacaa acggcttcga agcatagcgt aatcctgcgg ctgatcaaag ggcaaaggct 1145821 cctcaagcca gccaatgttc gtccattcgg agaaatagcg ctcccattta aaagccgcag 1145881 cggcatcgta gctttggttt gcgtccagaa tcatcgtaat ggagctgcct gctgtatgct 1145941 gcagcgcatt gatgtgccgg acatcctcct tgaatgaagt cccgccaatt ttgactttga 1146001 tttgctcaaa accttttttc aactgggctt caacattgga gactgagcgg ctgatccatt 1146061 gcggggagtc tgagtacgat tgaaaagacg cgtacacagg aatctcctct ctgtatcgcc 1146121 cgccccataa ttcgcaaacc gaacaatccg cagctttggc tgcaatctct gtcagcgcca 1146181 tgcttacagc ggaggccgcc cgctggtgcc atttttgaat cgtgcgcact aatgacaggc 1146241 ggctgccagc ctgttttcct aatagaaatg ggatgatccg cttcgtaaaa ccgacatgga 1146301 gagcagggag ccaatcaacg cattctcccc agccgtctat cccgctttcg gtgataatcc 1146361 tgatgagata acaagtccga tatcgtttaa acccattggc atctccgtat ggcttttcta 1146421 atcgatgaaa tagcggaaag gtttcaatcc gtacaatttt cacactgggt gctacctttc 1146481 ctcagcgggc tggagccgat tgccagccat tttagggtct tctttttctt ttgtttcttc 1146541 attgttttgc ttcacatgga tgagcatcat cacaagaatc ccgacaacga gagtcaatcc 1146601 cgcgatgctt aaaaacatgc cgggtctgga ccattgcatc aggcggccga aaatcggagg 1146661 accgatcgct acccctaaga aacgtacaga gccgtacagc gaggtgacaa atccccgtct 1146721 ttctttgccg acagccccgg taatgaaact gttcacacaa ggaaggacaa gacctgagcc 1146781 tatactgctc agtacaagaa cactgataaa aaggacaaga ttttcaatga atgacagtgc 1146841 cgcgtaggat acggtcatga acgccaatcc aagtacgatc agctttttca ttaacgattg 1146901 cttttgcccg attttgcttc ctgttgtata ggacgtcaca cacataacca aaagcgggat 1146961 cgctaaaatt aagccttttt tcacgccgtc ggtgtcgtat gttttttcaa gaacatctga 1147021 gagataaaac aggatgccga ataaagtaaa caaacaggtc gcaccggcta aataagcggt 1147081 aaacagccat ctgccttcat gtttaaagac acttaacagc ccttttgcat attgtccgat 1147141 tggtggcggt tctttttcct ttttcttttc tttaataaaa atccaagtca gtacgatcga 1147201 aatgatacaa aacacaggaa aggcaaaaaa cgcgccatac cagacaagca gggcgatcag 1147261 cgagccaatg atcggcgata gcactttccc catgccgttt gaagcttcaa caaggccgag 1147321 caccttgctc tcctgggcgc ctttaaacag atctcccgtc agtgccatgg caattgggcc 1147381 ggttccggct gccccgattc cctgtaacgc tcgtcctgcc atgacccaag gataggcatt 1147441 gtcaaaaaaa cctgccgcaa acccggctaa caaaccgccg gcaccataca aaattaagca 1147501 gggaataatg atgactttcc ttgagaatcg gtctgcgaga taaccgacaa tcggaatcgc 1147561 aaatgctgca atcaaggaaa atactgtgat cacgagactg acttgaaatt gtgataaatg 1147621 aagttcagat ttcatttttg gcaaaatcgg aataagcatc gagtttccta gggttaatat 1147681 taaagggatt gaaccgattg ccacaatcgt cattccgtta ttttgttttg atgattccat 1147741 ctcagagcac actccttttc ttctgcttag aatgtccctg atggcttcgt ttattcagcg 1147801 atcagacagc aaaaaaccga acagaagata cctgttcggg aaaaaagagg gttaaccgag 1147861 agcctgtgaa atcaaagcat ataagtgtcc attttgaata ggcgcttttt tctgatagaa 1147921 caaaatcgga ggttcatcat ctttatgaaa tcccatttct atcaggctgt catgcagaga 1147981 cgtgtgttca ctcggtatat cgattcgcat cggcccttgt ttgccggccg ccagccttgt 1148041 aattatctgt gctgcaacat ctgatgatgg agcgatgata gggccgaatt tcaaattggc 1148101 cggtgtctgt acagaaagtc cgtagccaat gagctgtccg tcctgatttc tggcgatgat 1148161 acattcgcat gaagcagaaa taagctgctg caaaaggttt gatcgatctc cgccaaaggc 1148221 agccagatcc gccgcggtta agtcgtgaaa gtcttgttct ctaaaggatg tcagttcagc 1148281 atcaagcttt tttgtataag gttgaaaact gtgacagctg tactttcgca ctgaacctgc 1148341 cgtatgaaaa cctgcttttt cataaagcgg caaaccttct tttgtggcgc aaagcctgat 1148401 ggcggtgttt tcatccgttt gggtaataca ggcgtttacc atacgccggc caagaccgag 1148461 ccgttgatat tccttgtcaa cgataacaag gccgatagaa gtaagacggc caaacaaaaa 1148521 caagccgatg caggaaataa tatcaccgct gacattttga taaccgaaaa agcgtccctg 1148581 ctgaacaagc agtttcagct cttgttcgcc ataatccggc cacccggctt gcccgcaaag 1148641 ccgcaataag ccggaaacgt gttcttcatg aagcttaatc agttcatcta ctacgtccat 1148701 aagatcacct gcttgttcta agtgttttgt acatgacaat atgattgcca atgccgggaa 1148761 tgtcaaatgg ttcgccaagt tccttccagc caagcttggc atagtagccc ttgacatggt 1148821 gtcttgcgtt gcaccatacc gcctgaacgc cgctctccgc cagtttgtgc tccgcgtgtt 1148881 tgatcagcgt gcttccagct ttttgatcgc gatatccctc gagcgttgcc atgcctctca 1148941 gccgatacgc agaggcttcc gttaataaag gctgactttg cggggaaaaa gaagcgatgc 1149001 tgatcagcgt tccatcataa aacacgccga gatgaaagga gccttctgcg tgatcctctt 1149061 tatatttgca ttgttcgatg gattgatggg gacgcagaat gcgatgccgg atttcatatg 1149121 tatcttccac ggaaatggtt ttgacttcga gcataatgtt cctcctcatg attgtttttc 1149181 tatatcgtaa cacgaatctc gttgaaaaag actgcccgat tcgatcaggc agtcttttgg 1149241 aaattaatgc aaaaagatat tttggcgctg ctcatctttt tgctgaatat atgatgtgag 1149301 ctcagcggtt aagtcagatc tgaggaaagg cgttatcaag tagatgccgt taaacagctc 1149361 gcatgccgta tccagcaggg agcgtgcaat tgcaaggcct tccgcctttt gcttttcttt 1149421 atcttcaccg gcatgggcca ttttttcgcg aatcgtatca gacagcttaa tgccgggaat 1149481 ttcattatgg atgaattcgg cattccggct gcttgtcagc ggcatgatgc cgatatagat 1149541 cggcgtcttc agatgttttg tttcgttatg gatatcgaca agctgctgct cggaatagac 1149601 aggctgagaa acaaaataat ctgcgccgca atctattttt ttctcaagcc gttttaccgc 1149661 tttatccaga tggcggacgt taggattaaa tgcggcggca actgagaaat tcgttttctt 1149721 gccgagcggt tttccagaca gagacagacc ttcattgaat tgtttgatca gcctgattaa 1149781 atcaaaagat gttaaatcat atacagacgt cgccccagga aaatccccga ttttagaagg 1149841 gtcacctgta atagcaagca cgtcattcag ccctaacgta tcaaggccca ttaaatgtga 1149901 ctgtaagccg ataatgttac ggtcacggca cgtaatatgg acaagggaac gcatatcgag 1149961 ctgctgcttg acaagggcgc cgcaggcaac attgctgatc cgcggggtcg ccaaagaatt 1150021 gtcggcgagt gtcagggcat cgattcccgc ttcttttaat tcagcagcag cggacagaaa 1150081 tttgtcaaag cttagttttt tcggcgggtc cagctctacg ataatagagc gttttttcgc 1150141 tgcgatctca tccaggccgg gctcggttcg ctcgtgatga acagaaatga attctttcgc 1150201 ccgggttttg acttcttttt ccgtaatcgg agccagcccg ccaaccgctt ccgccatcgc 1150261 cctgatgtga ttcggcgttg tgccgcagca gccgccgata atccgcgcac cttgcttacg 1150321 gaattctgac gcgctgtttt gaaaatacgt gtcgtctgtt tcatagacga gccgtccctc 1150381 ttcaagcgaa ggaagactgc tgttcggata aacggataag aatacgtcat caaaaatcgg 1150441 cacttcgctt agcgcttcaa tcatgtgata agggccgagg cggcagttaa tgccgacaat 1150501 atcagctccg agatccgcaa tcgagcgcaa tgcgtcagaa agcggcgttc cgtcctgcaa 1150561 tacgccttgc tcgtgcatgg agacattgag cataatcgga agatcagtct ctttgcgcgc 1150621 gattttcagc acttcacggg cttcttccaa atcataatat gtttctaaca gcaagccatc 1150681 cggctcttca tgcagcagca gatacagctg ctcgcggaag ctgcgcttaa tttcgtcaag 1150741 actgtatgcg tttttattaa atgtgcgtat gccgcccatc gttccaagca cgtatgcatc 1150801 gcctgctgaa gcccgcgcga tctttacggc ctcctgattc atttttttga tgtcatcctc 1150861 aagcccgtgt ctggataatt taatatagtt ggctccgtac gtattcgttt gaataatgtt 1150921 ggctcccgct tcaacgtacg ctttatgtat gcgctgaatt tcctccggct ttgaaatatt 1150981 gagctcctca aaacacctgt caatgccata ggagtagagg agcgtcccca tggcgccgtc 1151041 accgattaac acctgtcttt gcaaatcttc taaaagtccc attgtctgcc tcctttattc 1151101 acatcagcaa ggaaaaaaga gaaataaaaa aagtcctctt aagaagaaga ctttgtcagt 1151161 gattttgtct cttcttatct tccaagctgt tcgagcttgc tggatttagc accttggtca 1151221 tggctgatcg ccattacacc ggttgctgaa gcttcgtcgg gccagtccct ctgcttctct 1151281 tgataagaac ggatatgaaa ttttcgtgtc aggaagtgcc aaaagatatc tggcgttttt 1151341 ccctttctcc aaatttaccg aaaataaaga caataatcaa taggaatcag aaaatttatc 1151401 tgaaatttat aaattgaacg tcaattggca gatctgctcc ccgtacagct gagataatct 1151461 gctgcaggtc atctttgttt tttccggtga cacgcacttg atcatcctgc acctgagact 1151521 ttactttcag tccggagttt ttgatgatcg tattgatttt ttttgcgttg tccttgtcaa 1151581 tgccttgaac aagctttgca cgctggcgca ccgttccgcc tgacgcgttt tcaaccttgc 1151641 cgtaatcaat gttttttgtc ggtacgtttc gtttaatcaa tttgctgacc agcacatctt 1151701 tcagctggct taatttgaat tcgtcatcgg aaacgaggac cagctcctct ttatctaaag 1151761 aaatgtcgct tttgctgcct ttaaagtcat atcgggtact gatttccttc agtgcgattt 1151821 ggattgcgtt ttgcacttca ggcaattcca ccttggatac aatatcaaat gaactttctt 1151881 ttgccatatg aaaacctcca taacatttaa cttatgtgtt gattatagta gaataaagag 1151941 aaacttccaa cagaacaaag aatcaatttg tgatgattgg aaaaaatgtt aacaaaatcc 1152001 gcagagaata agcggaacag gaaggacgat agcatgagac cagggcagca attaaccttg 1152061 agtatagatc accaaaccga cttcggttac tttttaaccg atggggaaga tacgattctc 1152121 ttacataaca gtgaaatgac tgaggatatc gaggacagag acgaagtaga agtctttata 1152181 tacgtagacc agcaggaaag gcttgcggcc acgatgaaaa ttccgatcat cagcgcggat 1152241 gaatatggct gggttgaagt ggtggataaa gtggaagata tgggcgtttt cgttgatgtc 1152301 ggtttatcga aggacgcact agtcgcaact gagcatttgc cgccgtacga agatgtctgg 1152361 ccgcaaaaag gggacaaact ttactgtatg ctgaaggtga cgaaccgggg gcgcatgttt 1152421 gcgaaaccag cgccggaaga tatcatcagc gaactgttta ccgacgcttc agaagatctg 1152481 atgaataaag agctgacagg tacggtgtac aggctgatcg catcgggttc attcgtgatc 1152541 acggatgacg gtatccgctg ttttattcac ccgtcagaaa gaaaagagga gccaagactg 1152601 ggttcaagag tcacaggccg ggtgattcaa gtgaaagaag acggttcagt caacttgtcg 1152661 ctgcttccga gaaaacagga tgcaatgtca gttgatgctg agtgcattct aacgtatatg 1152721 agaatgagaa acggtgccat gccgtacagt gacaaaagcc agcctgacga tatcagagaa 1152781 cgttttaata tgagcaaagc cgcctttaaa cgcgcgctgg gccatttgat gaaaaacgga 1152841 aaagtgtatc aggaaaatgg atggacatac gagaaaaaat agcatgaaaa cggctcgcct 1152901 gcagcagact gcggagcgag ccgttttttt atgtctagtt taattcatca accagcgttc 1152961 tgattgccat ttcgcgatcc acattgtctg aaatcgcaat cggcgtaata tcaatggcga 1153021 gaatgatcag aatcagggca cctgctgcag caacataaga aacataatag aaatagttag 1153081 cggtatcaac agtgttgaca agctcggcct gaactctgga tgtatcatcc ttagaagcgg 1153141 cgatttcctt tgcagcttct actttttctt caacgatttg acctgctttt ttcagcagtt 1153201 catccacttt caatgcatct ttgctgtaaa cagctttctt caggttatca aaaaagtcag 1153261 catcctcttt tttaatatca gcgacaacct gattggcaaa agcctttgcc tgttttgtgt 1153321 tgagtttgtc tgtcatcgct ttattaaaga cctctggaag ctgtttgcca acttcccctt 1153381 gggcaaacac aaagccttta aaaatttcct cacctgaata ctcaagctgc tttgcctgtg 1153441 ccacactttc ttgctgcttc accaaaaaca cagtcgtcac caatacaacc gacaaaaata 1153501 ctagaaacgc cttcttcaaa ctgaaacctc tcccttcttg tgttttttat tccacaacag 1153561 tctgcgaata tatgtaaatt gaatcgtgga atcgatagga gtgagataca atatcaaaat 1153621 gccggccatg ataatcgaaa aactgatgag gcccagcatg actgcaaaaa tctcatgcat 1153681 aaaaacagcg atgatcaaaa tcaatctcca atgcttcttc ggcgcaaaca gtgccgcgaa 1153741 gatgacaatt tgaaccagca gcgtccccca tgtcggaatc accacgaacg gacttgttac 1153801 aattggcttc gttaacgcct gaaaaaagcc gttgaagcca atggtttttt cctgggcgaa 1153861 ataatagacg gccgttccgt ccacccattc ctgctgagat agcttagcga cggtagagtg 1153921 aaaataaagc accgccactt ggattctgat cacaaaataa gaaataaaag ctgttatttt 1153981 tccaagtgtt cttttgccct ctataggtct cgtactccaa tgccattttc tcggatcggt 1154041 cagcgtgatg ggaagcaata aaaaggtcat gactgctgct gcctgctcgc ctccgtcgat 1154101 gacgatcagc gatgactgca ggctgtaact gacataccaa tgcagaaccc cggtgattct 1154161 ggggcgccag ccaatgacaa caagcaccag aatggcaatg cagacccatc tgaaaagatt 1154221 taacatcata tagttatttt cgccgagaca aaagagactg agattcattt tacaagctgg 1154281 atagctgctg atcccgctgg ctggcttcat aatgaggctc gggtgattga tgagcagcgt 1154341 cagcaggctg gatagcgcaa tgatgcttcg cgcgaggcca tatacatttg tccacgggtt 1154401 tctttcgtcc catctggtga tggtctgttt tatgttttcg agcatgagat cacaaccttg 1154461 actatgcttt ttacctgata agacgaaggg gtatatttag aatagctcca aggaacaata 1154521 tcctctttcg tcaaatagta gctgccacaa agcagcgggc ggggagcggg tgtttttaat 1154581 tgcacggttt tggctttgct tttgcatgcg ccgaggtcct tttctttaca tgctgtccac 1154641 tgttccttgc cgacttggct gtagatcacg cccatttcaa cgccttgtga ccgcccatac 1154701 cgatacaggc cgaataggtt gtcagccctc atattgggcc atctgacctt ggcgctggca 1154761 ttttcagcct catataagcc gattgcagta tcacgcggat ttttgctaaa aaagccccag 1154821 ccctgaggga ggatgctgga catgagaaat ttggagtcct ttgtcagcgg aatcggggtt 1154881 gtccctaagc tgccaataat agaaaacaga aatagcgaac cccaaaggat tgaaaaaatg 1154941 acaaaaaatg atatcgattt ctgcattcga ctgctccttt taacctgaag aatcgttttt 1155001 acacttttca taatataaaa acatttatgt aataaaaagg ttaaaaagta tgagaaattc 1155061 catttttgtt aaaaggaaaa acaggacatt ttacactgct atatgtgatt gatatatagt 1155121 gtttttttcg atatatttaa accatgaaaa cgaatcaagt taatgaccgc tggattgttc 1155181 aatttcgaaa agggattttc gagctggcca tcctatccct tctgcgttct aaaccgatgt 1155241 acggttatga gctgacgtca tccttaaaaa ccacctcggc gctggctatt tcagagggag 1155301 cgatttatcc gattttgaaa cgtatgaccg agaagggatg gatcgaattt ttttgggaag 1155361 attcactgga cggcccgaaa agaaagtatt acaaaatgac gcaaaaagga gaagaaatgt 1155421 taaaagaacg gctggagaaa tacctggaaa cccatcaagc cttactgtct ttatcggggg 1155481 atttgctatg aatggacagc ttatcattga ccgatacatg gaggaactaa atgcagagct 1155541 ggcgaatatg cctgatgtag agagagaaaa cgctatcgac gaattaaagg ggcatatcac 1155601 cgctttcgtt caagacagaa tcaaagccgg ccttagtgaa gaggaactgc aggaagctgt 1155661 tgaatctgaa ttttctcatc cgaaggagct tgccgaattg atgatgggtg atgggggaga 1155721 gacgaaaagg aggaggtctt tattgggcaa aagctggatt tcggtccttc tcattgtcac 1155781 gattatcgcc ctgccgctgc tgccgtccga cttcagacat ctgccgctgg ctgtttattt 1155841 aatggtgctc gccggatatg tatggaagcg gaaaaaattg gtgatgtttg caggtgtcag 1155901 aaaaaacaaa atgcgctctc aaaaggagat tgtcaagatt tcgcgagtcg gtgcggttta 1155961 tctgctgttt ttagcagtgg tgctcctttt gagcccgttc ctcaatgcgc ttgtcgtcct 1156021 gctgctgatt gcagtaagct gcgccgcttt ttttcttttt cttaacatca agtaatcttg 1156081 taggaggctg taagatggaa atcagcatca attatctatt aattgtcatc gcgcttttat 1156141 tctttgtggt tgcctatttt gtcggaatca aaaaacaaac ctggatgttg gctgggttta 1156201 acgaggcgcg tatacgggat aaagatcggc tggccagaat agcaggctac tttttcttga 1156261 attccggttt gttcattttg ctgaatagtt ttatctcatt tcaaggtcag gagcagctca 1156321 tacctccgct tatactggca tatggagcag gggttattat ttatgtcaat aaaaaattag 1156381 tagagtagaa aaagaagggc agagcgaaat atctctgccc ttcttttttg ggaaaataag 1156441 aacgaagcac cacatacaag tttttgtatt tttgatagga tgaagaaaaa tggtagattc 1156501 caaaatagga aggatgtggt gttttgcgca acttgaccaa gacatctcta ttactggccg 1156561 gcttatgcac agcggcccaa atggtttttg taacacatgc ctcagctgaa gaaagcatcg 1156621 aatacgacca tacgtatcaa accccttcat acatcatcga aaagtcaccg cagaagccgg 1156681 tacaaaacac aacccagaaa gaatcgctat tttcctatct tgacaagcat caaacgcagt 1156741 ttaagctcaa agggaatgcg aacagccatt ttcgcgtttc gaaaaccata aaggatccaa 1156801 agacaaaaca aacgtttttt aaattaacgg aggtttacaa aggaattccg atttacggct 1156861 ttgaacaagc ggtcgcgatg aaggaaaaca aacaagtgaa aagtttcttt ggaaaggtgc 1156921 atccgcaaat caaggacgtc tccgtcacac cgtctatttc tgagaaaaaa gcaatacata 1156981 cagcaaggcg tgagctcgag gcttccattg gaaaaatcga atatcttgat ggggaaccaa 1157041 aaggcgaatt atatatctat ccacacgacg gtgaatatga tctcgcctac cttgtgagac 1157101 tctcgacatc tgaacctgag cctggctatt ggcattattt catcgatgcc aaaaacggaa 1157161 aggtcatcga gtcctttaat gccattcatg aagcggcagg tacaggaatc ggcgtgtcag 1157221 gtgatgaaaa aagctttgac gtcacagaac aaaatgggcg cttttatttg gctgacgaaa 1157281 caaggggaaa agggatcaat acatttgacg cgaagaacct gaacgaaacc ttgtttacgc 1157341 ttttgtctca actgatcggg tatacgggca aagaaatagt cagcggcacg tccgtattta 1157401 atgaacctgc ggctgtagac gcacacgcaa atgcgcaagc cgtttacgat tattacagca 1157461 agacatttgg ccgtgattct tttgatcaaa acggagcaag gattacgtct accgtgcatg 1157521 tcggcaaaca atggaacaat gctgcgtgga acggtgtcca gatggtatac ggggatggag 1157581 acggttcgaa atttaagccg ctgtctggat cgctcgacat tgtcgcgcat gaaatcacac 1157641 acgcagtcac acagtattcc gccggtcttt tatatcaagg agaacccggt gcattaaatg 1157701 agtccatttc tgacattatg ggcgcgatgg ctgaccgtga tgattgggag atcggcgaag 1157761 atgtctatac tcctggtatt gcaggagatt cattgcggtc attggaggac ccatctaagc 1157821 agggaaatcc agatcattac tcgaaccgct acacaggaac agaggattat ggcggagtcc 1157881 atatcaattc gtccattcac aataaagcag cttatcttct tgcagaagga ggcgtgcacc 1157941 acggtgtaca ggttgaaggg attgggcgtg aagcaagtga acaaatttac tatcgggctt 1158001 taacatatta tgtaacggca tctacagatt tcagcatgat gaagcaagcg gcgattgaag 1158061 ctgccaatga tttatacggt gaaggctcga agcaatcagc ttcagtcgaa aaggcgtatg 1158121 aggctgtcgg cattctatga gcaaacaaaa acagtcagga cacagagtct gactgttttt 1158181 gtttgctcat tttcttaaaa agaatatcgc caatgtacct ggaccggcat gcgagccgat 1158241 ggctgaactg attggatgca taatgatttc tttcggcttg aacgcttcct caatcaggtg 1158301 tttcatatcc gtggcttttt ctttgttcgc ggcgtagcta atcccgacgg tttgattgct 1158361 ccaatcatcc ccgcgctctt tcataagctc gatgatccgt ttgaaaagtt tcttctgtcc 1158421 gcgaattttt tccagaggca caagcttgcc gtcctccatc tgaagcagcg gtttaatatt 1158481 caacaggccg ccgacaaaag cggacgtttt ggatatccgg ccgcccctcg cgagatatgt 1158541 taaatcatca acggtaaaaa tgtgttcaag ctggctgcaa aagttcttta cagacgtttc 1158601 aatttcttgt attgtattcc cgttgataca gagatcggca gcatgccgga cagccagacc 1158661 gtatcctaat gaagcgcatt tggaatcaat gacccgcaaa tcgaaatcgg ggaattcctc 1158721 cttcacttca ttggcgatca ttacagctgt ctgatacgtg ccggagagac ctgaggaaaa 1158781 ggcaatgtaa agagcgggat cacctgtttc ggcatattgc aaaaacacat ttttaatcgt 1158841 ttgcggtgag gcttgggacg tcttaggcgt ttctccattt tgcatcgctt caaatatttg 1158901 atccgcatga attgtgactg catcttcgaa ttctttatcg ccgagagaaa ccctgagcgg 1158961 aataaagcca atgccttttt cttcaaaata agaacgaggc aaatcagtgg cgctgtcagc 1159021 gatgagatga actgtcatat tgcttccctt ctttccgtta tcgctcgtta tcatgagagt 1159081 taagccaact atatcatatt aatttgccaa aatcgtgttc aaatatttgt tttaagggaa 1159141 aacataataa agaagaaaga gcggaggaac atgccatggt actagatcaa acaaaaaaat 1159201 tactcatcgt catcatcggc gctttactca atgctgccgg gctgaactta tttttgatac 1159261 ctgcagatgt atatgccagc ggatttacag gtgttgccca gcttttatca agcgtcgttg 1159321 atcaatatgc ccccttttac atatcgacgg gaacgctctt gttcctctta aacattccgg 1159381 tcggtatttt aggatggctg aaggtcggca aatcgtttac agtgtacagc attttaagtg 1159441 tcgcactcac tactctgttt atggggatcc tgccggaaac aagcctgtca catgacattt 1159501 tgctgaacgc ggtgttcggc ggcgtcattt ccgcagtcgg tatcggctta acattaaaat 1159561 acggagcttc gacaggcggg cttgatatcg tcgccatggt acttgcaaag tggaaggata 1159621 aacccgtcgg cacgtatttc ttcattctga acgggattat catcttgacg gcaggattat 1159681 tgcaaggttg ggagaaagca ttatataccc tggttacact atatgtgaca acgagggtga 1159741 tcgacgccat tcacactcgc cacatgaagc ttacggcaat gattgtgacg aaaaaagcgg 1159801 acgaaatcaa ggaagccatt tacggaaaaa tggtgcgcgg catcacaact gttccggcaa 1159861 aaggagcatt tacgaacgaa cagaaagaaa tgatgattat cgtcatcacg aggtatgaac 1159921 tgtacgattt agaaaagatc gtcaaagaag ttgatccaaa agcatttacg aacatcgttc 1159981 aaacgacagg gatttttggt ttctttagaa aagactgacg aaagcaggtg gaagtcgtga 1160041 aacggctgct tgtgatgctc ctccccgtgc tgcttttgat aggctgcggg aaagatgagc 1160101 agacagaacc cgataaggag gtatcaggcg gaatggagaa tcaagaggtt gttttatcta 1160161 ttgacgcaat tcaggagcct gaacaaatca agtttaacat gtcgctgaag aaccaaagcg 1160221 aacgtgctat tgagtttcaa ttcagcacag ggcaaaaatt tgaacttgtc gtgtatgatt 1160281 ctgagcacaa agaaagatac cgttattcga aagaaaaaat gtttacgcag gcttttcaaa 1160341 acctgacgct tgaatctgga gaaacatatg atttctctga tgtgtggaag gaagtccctg 1160401 agcccggaac ctatgaggta aaggtgacat ttaagggcag ggcggaaaat ctcaagcagg 1160461 ttcaggctgt tcagcagttt gaagtcaaat aagaggctat ggcgagtcgc catagccttt 1160521 ttttattgca gtttgtccag ctgattttga aattgatgca actgttgacg ttccgcatct 1160581 gtcgaattgg catacgcaga agatacagca tttttggctc tcagaatcgc ttgctcctga 1160641 tcgccttcct caaagccgtt tgtcaccatg accgcctgtt gaacaaatga ttttgcctgc 1160701 tgaaacagtt catttctcat ttaatattca tactgccttt cagccgagtc tcgtgccgcg 1160761 gcatgctggt gagcttcttc taaagtagac cgatatggaa atcttgcggc gtgtagcccg 1160821 atggagtctt taccctgctg aataaacctt ctggatttgc ttcgtttacc cattttgaga 1160881 ctgccccctt ccatactttg acgagatgag tcgtcttcaa tagtatggtg gggtaaagta 1160941 aggtttatga gtgggaaaaa ttaatacgga ccttctttaa agtgagaaat attctttcaa 1161001 aaaccttgcc acgccgtcct cttcatttgt ggccgtagtt cggttggcaa tctgcttgac 1161061 cgcgtcaatt ccatttccca ttgcaacgcc gcagcctgca aattcaagca tttccaaatc 1161121 gttatcctca tctccaaaag caatgatccg ctccctcggc acgccgtaat aatcgctgat 1161181 tttctgcagg ccgaccgctt tattcatgcc gcttttgata atttcaatga catgccaagg 1161241 agcggcccat cttctatggt cgatcacctc ggcatgcaca tccgataaat atgagcgtat 1161301 tgccggcaca tcctcttcct ttgcatgtat gagtacggac gtcacatctt caccgagatt 1161361 ttcccgcaag tctccgaccg ttacatttgt tgtgttcatg ttaaaggcat ctatcaggtg 1161421 ctcatcatgg taatgaaagt atacgtcgtc aatcacttca gcaagcacgt tatgtacgtt 1161481 gtagctctcg ctgatatcca cgagctgttt gacaacatca agcggcagtg acgtatgata 1161541 ccgtccccag ctgtcgtctt gcggatgatg gacaaatgct ccgttaaaat tgacaattgg 1161601 cgttgtcagc tccatctgct ggtagtacat ggaacttgaa cgatacggac ggcctgttga 1161661 gatgcagaca taatgcccgt catcttttag gcgctgtatc gtatgaaggg tgttttcaga 1161721 tatggtttta tcatccttta ataatgttcc atctaaatct aatgcgatta aatagggttt 1161781 tgtctccatg aaaagctcct ttaaccttag attttgcttg ttttgcctta cttacagtgt 1161841 agctttttac catctttatt gtctacatgt tacacttatg attatggtta tcctaaggag 1161901 gggcacattg tgatacaaat tgagaatcaa accgtttccg gtattccgtt tttacatatt 1161961 gtaaaggaag agaacaggca ccgcgctgtt cctctcgtga tctttataca tggttttaca 1162021 agcgcgaagg aacacaacct tcatattgct tatctgcttg cggagaaggg ttttagagcc 1162081 gttctgccgg aggctttgca ccatggggaa cggggagaag aaatggctgt tgaagagctg 1162141 gcggggcatt tttgggatat cgtcctcaac gagattgaag agatcggcgt acttaaaaac 1162201 cattttgaaa aagagggcct gatagacggc ggccgcatcg gtctcgcagg cacgtcaatg 1162261 ggcggcatca caacgcttgg cgctttgact gcatatgatt ggataaaagc cggcgtcagc 1162321 ctgatgggaa gcccgaatta cgtggagctg tttcagcagc agattgacca tattcaatct 1162381 cagggcattg aaatcgatgt gccggaagag aaggtacagc agctgatgaa acgtctcgag 1162441 ttgcgggatc tcagccttca gccggagaaa ctgcaacagc gcccgctttt attttggcac 1162501 ggcgcaaaag ataaagttgt gccttacgcg ccgacccgga aattttatga cacgattaaa 1162561 tcccattaca gcgagcagcc ggaacgcctg caatttatcg gagatgaaaa cgctgaccat 1162621 aaagtcccgc gggcagctgt gttaaaaacg attgaatggt ttgaaacgta cttataaagc 1162681 actaagttat taacaagagc tgaatttacg ttatactgta gaaaaaagga gtgagggaac 1162741 gtggaagaag cattaaaaga aaacatcatg ggcgccctgg aacaggttgt cgatcctgag 1162801 cttggcgttg atatcgtgaa cctcggcttg gtatatgacg ttgatatgga tgaagatggc 1162861 ttgacgcaca tcaccatgac gctaacatca atgggatgcc ctttagcgcc gattatcgtg 1162921 gatgaggtga aaaaagcatt agcggacctt cctgaagtga aagacacaga ggttcacatt 1162981 gtatggaatc cgccttggac tagggataaa atgtccagat acgcaaaaat tgcgcttggc 1163041 attcaataaa acaaaaaagg acagcctgac atgtgaggct gtcctttttt acagctgaaa 1163101 ggagtgaaag gaaatgatgt acctgctggc agttttatgc ccgccgcttg ctgttttgtt 1163161 ttcgggaaaa ccgtttcagg ccttgctgaa tctcatattg acctgtatct tttggctgcc 1163221 gggcgcgatt cacgcctgct ttatcgtcgc cgaccgccgt gccgaaaaac gggcaagaag 1163281 ataatttgga aaaatgagga cgcagtcatg gtataatggt cataaaaaca gcagggagag 1163341 cactatgaaa aagaaattgc ttgcattcgc gctttgtact ggcgcgtatg cggccctgtt 1163401 tgcgtactct gtgaactcag agcaaaaaac agccacaagc gagatgacgg atgtcagccg 1163461 cctgatgcct gtaaaaataa agcagacagt gaaagggcag gaagaggaaa tgctcattga 1163521 cacagtcaaa gaggcaaatc gaaaaaacat aaaaatttca atcgccgggg cccagcactc 1163581 catgggcggc catacatatt atgaggacgg catcgttctc gacatgacgg gctacaacaa 1163641 aatcctgtca ctcgatcaag agaagaaaac catcagggtg caaagcggtg caacgtggaa 1163701 tgatatccag aaatacgtga atccatacgg actcgcggta aaagtcatgc agtcacaaaa 1163761 catttttaca atcggcggat ctctcagcgc aaatgcacac ggacgtgata ttcgctacgg 1163821 ctcgctaatt gatacagtca aatcattccg gcttttaaaa gctgacggga tgattatcac 1163881 tgtcactcca aaagatgatt tgtttacggc ggtcatcgga gggtacggcc tttttggcgt 1163941 gattcttgat gtaacgcttg agctgacaga tgatgagctg tatgtcatga agacagaaaa 1164001 aatgaattac agcacatact cagactattt ttcaaagcat gtaaaaggaa atccagatgt 1164061 ccgaatgcat ctggcgcgaa tttcaacagc gaaaaaagga tttctgaaag acatgtatgt 1164121 cacgaattac gtattggcta atcatcagga tcagctgtcc tcatacagcg aacttaaaga 1164181 agacgagtat acgggagcca caaagtttgc actcggcttg tcaagacggt atgaatgggg 1164241 gaggaattgg ctgtgggaca cacagcaatc ctatttcctg agccagaacg gcacagagat 1164301 ttcacgcaat aacgtcatgc ggtccgaatc aaagtttctt gagtatgaaa acaatgacaa 1164361 cacagatgtt ttgcaagaat actttgtgcc cgtgaaggag tatgggtcct atattgatga 1164421 cctgagacaa acgctgtcgg acgaagatct gaacctgctg aacattacga tccgctacgt 1164481 gcagaaaaat gaaaaggccg acctttccta tgcgaaggac gatatgtttt cgctcgtact 1164541 attaataaac gagggctttt caaaagaaga ccaggcagat accgcccgaa tcatcaggcg 1164601 catgacagac gttgccatca agcacggcgg cagctattat ctgccttata tgacctacca 1164661 gacaaaagcg caaatgagac aggcatatcc gaaaagtgaa gcgttttttc agaaaaaacg 1164721 aacctatgac ccggatgagc gctttatgaa ttacttttat cagaggtata aataatgggg 1164781 aaaaacaaat taaaatggct gacattatca caaagcagcg tgtttttcgc aagcagctta 1164841 atctttccgt tttatattct gtttgtgaaa aatatcggct caagctacac acagttcggt 1164901 ttttcctacg gattgttcgg gttgagcgga gcgcttattt acccgctcct cggacggctg 1164961 tctgaaaggt ttgacagccg ttattttctg cttctgaact cgtgggggat ggctgttctg 1165021 cttttatatg tcccgcatat cggaagcgtc gttcaagtgt atatcgtcca agtgctgtta 1165081 gggctctttg gagcgatgca aaagcatgga gaaaaagtgc tgatcgctaa ttttacagac 1165141 agtggagagc gtggaaagaa gatcgggaat taccattttt ggacagctgt cttttcagca 1165201 gcagccatta tgctcggggg ctttctcgct gactttttca cagtgcaaat gattttttat 1165261 gcaagctcta ttctatattt tttgagtgga ttgatgatga tgaaaacagg ctgacgcggt 1165321 cagcctgttt ttttatgcgg ctgaaatgcg gcaccgcatc aacgtttttg tgctggagtc 1165381 gtgctgattt tttttgagcg gaattcccat tgaacagaaa atttataaat gaataaaaat 1165441 attaaatata cgattgaatt aatttttatt catgttataa tgttaaataa tttcacaaag 1165501 accaagaggg tgaacttgtt ttgaaaatag gaattgtagg tgctacagga tatggaggca 1165561 ccgaacttgt caggattctt tcgcatcatc ctcatgcaga ggaatgcata ctttattcat 1165621 ccagcggaga agggaatgtc tatagcgagg gttatcctca tcttaccggc ttagcggatc 1165681 agcagctgaa gccgattgat atgaatacga tcaaacacga aatagatatc atgtttctcg 1165741 ctgcgccgcc cggagtatca agtgaattga ctccaaagct ggcagacgcg ggaattacgg 1165801 ttattgatct gtcaggtgat ctgaggataa aagaaccggc tgaatatgaa aaatggtata 1165861 aacggacagc ggcaccgaag gcggtgattc aagaggcggt atacggtctg gcagaactga 1165921 atcaactgca aattcaacag gcgaaactca ttgccaatcc aggctgtttt ccaacagctg 1165981 ttttgcttgg cctcgcgcca ttggctcaaa agaaactgct cgatgaatct ttcgttatcg 1166041 ttgacgcgaa gaccggtgtt tccggagcgg gaagaaaagc atccatggga actcattttt 1166101 ctgagctgaa cgacaatttt aaaatttata aagtcaatga acatcagcac acgccggaaa 1166161 ttgagcaggc gctgaatgaa tggcagccag gtctcgggcc cattacattt tcggctcact 1166221 tggttccgat gacaaggggc atcatggcga cgatgtatac cagattaacc tgtgacctaa 1166281 ccgcagatga cctgcatgat ttatattcgg aattttacca agattcatat tttgtgagag 1166341 tgaggccaaa aggtcagtac ccgcaaacga aagaagtgta cggcagcaat ttctgtgata 1166401 tcgccgtgac cctcgatgag agaacgaaca gagtcacgat cgtctcggta atcgataatt 1166461 taatgaaggg tgccgccggt caggcagtgc aaaactttaa tttgatgaat ggctggaatg 1166521 aagaaactgg actcaccatc acgccaattt atccatagaa cgggagagaa tcgaaccatg 1166581 attcagttaa gtgaagatca aattgtaaaa gtaacaggtg atgtatcctc gccaaaaggg 1166641 tttcaggcaa agggtgtgca ttgcggactg cgctactcga aaaaagacct cggcgtcatt 1166701 atcagcgaga caccggccgt gagtgcagca gtttataccc aaagccactt tcaggctgct 1166761 ccgatcaaag tgacacaaga cagcttaaag cacggaccga cactgaaagc cgtcatcgtc 1166821 aacagcgcca ttgccaacgc ctgcacggga gaacagggct taaaggacgc atacacaatg 1166881 cgggagagct ttgcttcaca gcttggcatt gagccggagc ttgtcgctgt ttcatcaacg 1166941 ggtgtcatcg gcgagcattt agacatggaa aaaatccacg cggggatcga actgctgaaa 1167001 gaaacacctg cgggatcagg cgattttgag gaagcgattt taacaactga tacggtgatc 1167061 aagcagacgt gctatgaact ggcaatcggc ggcaaaacag tcacgatcgg cggagcggcc 1167121 aaaggctctg ggatgataca cccgaacatg gccacgatgc tgggatttgt gacaactgac 1167181 gcggcaatcg aagaaaaagc gctgcaaaag gcgcttcggg aaatcactga cgtttcattt 1167241 aaccaaatca cagttgacgg agaaacatcc acgaacgaca tggtattagt tatggcgaat 1167301 ggctgcgccg aaaacgagtg cctgacagaa gaccatccag actggccggt ctttaaaaaa 1167361 gcgctcttgc tcacttgtga ggatctagct aaagagattg ccagagacgg agaaggcgcg 1167421 acaaaactaa ttgaagccca agtacaggga gcgaaaaaca atcttgatgc aaacgtcatt 1167481 gccaaaaaga ttgtcggctc aaatcttgta aaaacggcag tatacggaac agatgccaac 1167541 tgggggcgga tcatcggagc catcggacac tccgcagcac aggtgacggc agaagaagta 1167601 gaggtttatc ttggcggcca atgcctgttt aagaataacg aacctcagcc attctctgaa 1167661 tctatcgcca aggaatacct tgaaggagat gaaatcacca ttgtcatcaa gatggctgaa 1167721 ggggacggaa acgggagagc gtggggctgt gacctgacct atgactatat caaaattaac 1167781 gcgagctatc gcacgtaata aaggggagcg aaatgaagaa aacaatcgtt tttaaatgcg 1167841 ggggaagcgt catccgtgag ctgtcggagg aattttatca aaatctgaaa gagctgaggg 1167901 cgtcaggctg gaagctggca atcgtacatg gcgggggacc ggaaatcaca aatatgctga 1167961 aacggttaaa tatcaagaca gagttttcgg gcggacagag gaaaacaacg aagccggtgc 1168021 tggaagtggc ggaaatggtt ttatccggtt ctgtcaataa atttttcgtt gctgagcttg 1168081 ccaaacacgg actgcgagcc gcgggcattt ctggtaagga tggcggtctt ttggaggctg 1168141 attatctaga tccggaaaca tacggagaag tgggagaaat caaaaaagtc gatgcgtcca 1168201 tggtgaacgc gctgatggaa aatggcatca tccccgttat tgcgccgctg tctatgacaa 1168261 gcgactgcaa aacgctgaat gtaaatgctg atctggctgc ttcagcagtc gccggagcgc 1168321 ttgaagccga taagctgatg ttcgtcacgg atgtcgatgg aatcatgaag gaaaagcagc 1168381 gtctggacgt cctgacccct aaggagattc agatgctgat caagcaggaa gtgatcacag 1168441 gagggatgat cccgaaggtc aattcagcct tgtcagcttt atcagatcag gtgtctgaag 1168501 tcatgatcgt aaacggtaaa ggatcattct tcgcagaaca aacctttcaa gggacaaaaa 1168561 ttgtcaaagc aaaggaggct gtttcatgag cagcttgttt caaacctacg gccgttggga 1168621 tattgacatc aaaaaagcaa agggaacgta cgttgaggat caaaacggca aaacgtacct 1168681 tgatttcatt caggggattg cggtatcaaa tctaggacac tgccatgaag cggtgacaga 1168741 ggcagtcaaa aaacagcttg acagcgtatg gcacgtatcc aacctgtttc aaaacagtct 1168801 ccaagagcaa gcggcgcaga agctggcagc gcatagtgcg ggagatcttg tctttttctg 1168861 caacagcggc gcggaggcga atgaaggtgc gataaagctt gccagaaaag caactggaaa 1168921 aacaaaaatc atcacttttc ttcagtcgtt ccatggccgc acgtatgcag ggatggctgc 1168981 gaccggacag gataaaatca aaacaggctt cggcccgatg cttggaggct ttcactacct 1169041 gccatacaat gatccttctg cttttaaagc tcttggggag gaaggcgata ttgccgcggt 1169101 gatgcttgaa acagtgcagg gagaaggagg agtcaatccg gcgagtgctg aatttttatc 1169161 agccgtacag tcgttttgca aggaaaagca agcccttctc attattgatg aaatccagac 1169221 cggcatcgga cggacgggaa aaggcttcgc atatgagcac ttcggactct caccggatat 1169281 catcacagtc gccaaaggat tgggaaacgg ctttccggtc ggcgctgtca tcggaaagaa 1169341 acagcttgga gaagcgttta cccctggttc tcacggaacg actttcggag gaaacatgct 1169401 ggcgatggct gctgtgaatg ccacattgca aattgtattc cagcctgact ttttgcaaga 1169461 ggctgctgac aaaggggcgt ttttaaaaga acagcttgag gcagagctaa agagcccttt 1169521 tgttaaacaa atccgaggta aaggattaat gcttggaatt gagtgtgatg gcccggttgc 1169581 tgacattatt gctgaattgc agacattagg cttgcttgta ttgccggccg gcccgaacgt 1169641 gattcggctg ctgccgccgc tcaccgtgac taaggatgaa atagcagaag ccgtcagcaa 1169701 gctgaaacag gcaatcgctc atcattccgc tgtaaaccag tgattttttt tcgatataaa 1169761 ggcataaaaa ttcattttta taattaatta ttcatcaaga ggtgggctgt tagatggaag 1169821 gttatttagt gttagaagat gggacatcgt tcagcggcga gctggacggt catgaaaact 1169881 gcacgggaga agctgttttt ttcacaggaa tgacaggcta ccaggaagtg ctgacagatc 1169941 catcatataa gggacagatt attgtattta cctacccgct gattggcaac tacggcataa 1170001 atgaaaagga ttttgaaagc aagaaaccgc aagtaaaagc cgcggttgtc tatgaggcgt 1170061 gtgatcactt ttctcattat gaagcggtat acagcctcaa ggagtatcta cagaaatgga 1170121 atattccgct gttaacccat gttgatacga gggctgtcgt gaagaaaatc cgggcaaacg 1170181 ggacgatggg tgcgacagtc acagcctcta aagaaggagc tgagattgcc cttcaaccag 1170241 agaatgtggc agagcaggct tccgcccagg aaatcagcac attcggcgac gggaataaac 1170301 atatcgctct cattgatttt ggctataaaa agtcaatcgc atcatcactt gtcaaacgag 1170361 gctgcaaggt taccgtggtg ccataccagc aaatggaggc cgtatacaac atcaaacccg 1170421 atggaattgt gctatcgaac ggacctggag atccgaaagc cattcagcca tatttaggaa 1170481 agatcaaaag catcatcagc cgctttccga ctctaggcat ttgtctcgga catcagctga 1170541 tcgcgctcgc gtttggaggg aatactttta agctgccatt cgggcacagg ggagctaatc 1170601 atccggtcat cgaccgtaag acgaaacggg tctttatgac aagccaaaac cacagctatg 1170661 tggttgatga acagtcgatt aatgaagaag agctcaccat caggtttcat catgtcaatg 1170721 atacgtcagt tgaagggctt gcccataaaa aactgcctgt catgagtgtt caattccacc 1170781 cggaagccca tcccggacct gcggaaagcg aatggatttt tgatgattat ctaaagaatg 1170841 tgataccagc aaggagagaa atcgcgcatg cctaaagaca ccagtatttc aagcatatta 1170901 gtaattggct caggcccgat catcatcggg caggcggcag aatttgatta ttcaggcact 1170961 caagggtgca tcgcgctgaa ggaggagggc taccgggtaa ttctcgtcaa cagcaatccg 1171021 gcgacaatta tgactgatga agccttcgct gatgaaattt attttgagcc tctgacagca 1171081 gaaagcctga cagccatcat taagaaagaa cggcctgatg ggcttcttgc caatttaggc 1171141 ggtcagaccg cgttgaattt agcggtggag cttgaagaaa cgggtgtttt aaaagagcac 1171201 ggcgtcaaac tcctcggcac atccgttgaa acgatacaaa aaggagagga ccgggaaaaa 1171261 ttccgttcgt taatgaatga attaaaacag cctgtgccgg agagtgaaat tgttgataac 1171321 gaggccgatg ccctccattt tgcggaatcc atcggttttc ctgttattat cagaccagct 1171381 tacacattag gcggaaaggg cggaggaatc gcccctgata aagaagcctt tacagctatg 1171441 attaagcagg cgctattagc aagcccgatc aatcaatgcc ttgtcgaaaa aagcattgcc 1171501 ggctttaaag aaattgaata tgaagtcatg cgtgacagca ataacacatg cattaccgtc 1171561 tgcaatatgg aaaatatcga tccggtcggc gtgcatacag gtgactctat cgttgtggcg 1171621 ccgtcacaaa cattgacaga cgaagactat caaatgctgc ggacagcaag tctgacgatc 1171681 atctcagcac ttgatgttgt aggcggctgc aacattcaat tcgcgcttga tccattcagc 1171741 aagcaatatt acgtcattga agtgaatccg cgtgtaagcc ggtcatcggc tctcgcatct 1171801 aaagcgaccg gttatccgat tgcgaagatg gccgcgaaac tggcagtcgg atacactctt 1171861 gacgagctga aaaatccgct cacaggctcg acttacgcaa gctttgaacc ggcactggat 1171921 tatgtgatcg tcaaatttcc gcgctggccg tttgataaat tcaaaaacgc agaccgcaag 1171981 cttggcacaa aaatgaaagc caccggtgaa gtgatggcga ttgaacggaa tttagaagcg 1172041 gcgatacaaa aggcagccgc gtcgcttgaa ttaaaaaata tcgggacaca ccttccagag 1172101 ctcagcgggt tgtcaattga tacgctatgg gatttggcaa tcactccgga tgaccgcaga 1172161 tttttcgttg tcatggagct gttgagccgc agcgtctcga ttgatgacat ccatgaaaaa 1172221 acaaaaattg atccgttttt ccttcatacc tttgacaaca tcatcaaatt ggaaaaccgc 1172281 ctgatggaag cagggagcga tctctctttt gaattattga agaaagcaaa ggaaaaggga 1172341 ttctcagacg caacgattgc ctcgctgatc agcaaaacag aagaagaggt gcgcgcgctt 1172401 cgcaaggaga tgggcattac gccttccttt aaaatcgtag atacatgcgc ggcagagttt 1172461 gatgcgaaaa caaactattt ttactccaca tatttcggag agaccgatgg agacatcagc 1172521 cgcaaagaga aaaaacgcgc gctcattatc ggatcaggcc cgattcggat cggccaaggc 1172581 gttgaatttg attacagtgc tgttcacggt gtgctgacac tgcaagagct tgggttcgaa 1172641 accatcatga ttaacaataa cccggaaact gtcagcaccg attatgaaat tgcggaccgc 1172701 ctgtattttg aaccgatgac aacggagcat attgtaaacg tggcggagca ggaaaatatt 1172761 gattttgcaa ttgtgcaatt tggcggtcaa actgcaatca atgctgctga agcgctcgaa 1172821 aaagccggca ttactcttct tggcacatca tttcaaacgc tcgacgtgtt agaggatcgg 1172881 gatcaatttt atcagcttct tgacgagctg ggattgaagc acgcaaaagg agaaattgct 1172941 tatacaaaag aagaagccgc ttcaaaagcg agtgagatcg gctatccggt gttaatccgc 1173001 ccatcttacg ttatcggcgg aatgggcatg atcattgttg actcgcaagc ccagctttct 1173061 cagctgctga atgatgagga cagcatgcca tacccgattt taattgatca gtatgtgtct 1173121 ggaaaggaag tcgaaattga tttgatttcc gacggcgagg aagtctttat cccgacatat 1173181 accgagcata ttgaacgggc aggtgtccat tcaggggaca gttttgccat tcttcccgga 1173241 ccgtccatca cgagcgggct gcagcagggc atgaaagatg cggcacaaaa aattgcccga 1173301 aaactttcat ttaaaggcat catgaacatt caatttgtga tcgacaatgg aaacatactc 1173361 gttcttgaag tgaatccgag agcgagccgc acggttcctg tcgtcagcaa agtaatgggc 1173421 gttccgatga ttccgctcgc cacacgtctg ctggcgggag cgtccttaaa agatctaaat 1173481 ccggcagttc aaaatcatca tggagttgcc gtgaagttcc ctgttttttc ttctcatgcg 1173541 atccaggatg tggatgtcaa gcttggaccg gaaatgaaat caacgggaga aggcatgtgt 1173601 gtcgcatatg attctaacag cgccttgaaa aaaatctata caagagtctg gagtcaaaaa 1173661 ggaagcattt atttgcaaaa cgttccggaa gatgtgaagg agttagcaga aaacgcaggt 1173721 tttacaatac atgaaggaac atttgcctca tggatggaac aggaaggaaa ctcgctccac 1173781 attaatctga gcggttctga agaagcacgc aaagaacgtt tggaagccat gacgcacggc 1173841 atccccgtct ttacagaaga agaaactgtg cgggcgtttt tacaaagcgg ttcaggccat 1173901 ccgcagcctg tatctctcaa agacctctat aaaaaggaag tggcatcatg cacacagtga 1173961 cgcaaaccag tttatacgga aaagatttat taacgttaaa ggaccttagt gaagaagata 1174021 taaacgcctt gctcgcagaa gccggtgagc tgaaacaaaa caaaattcag cctatattcc 1174081 atggcaaaac cttggcgatg atttttgaaa aatcatcaac gcggacccgt gtttcatttg 1174141 aagcgggcat ggcgcagctg ggcgggagcg ccctctttct aagccagaaa gatctgcagc 1174201 tggggcgcgg tgagactgtc gctgatacgg caaaagtgct gtcaggctat gtggatgcca 1174261 tcatgatccg gacctttgaa catgaaaagg tggaggaact tgccaaagaa gctgacattc 1174321 cggtgatcaa tggacttacc gataaatacc acccatgcca ggcgctggcg gatctcttga 1174381 cgattaagga gataaaaggg aagcttaaag gcgtaaaagt cgcgtacatc ggtgacggaa 1174441 ataacgtggc gcactccttg atgatcggct gcgcgaaaat gggctgtgat atctcgatcg 1174501 cttcaccaaa gggatatgaa gtgttagatg aagcagctga agcggcaaag acatatgcac 1174561 ttcaatccgg ctcttctgtc acgctgacag atgatccgat tgaagctgta aaagacgcgg 1174621 acgtgattta ttctgatgtg tttacaagca tggggcagga agcggaagag caagaacgtc 1174681 ttgctgtctt tgcgccttat caggtgaatg cggcgctggt cagccatgcc aagcctgact 1174741 atacattttt acattgtctc cctgcgcatc gcgaggaaga agtgactgcg gagattattg 1174801 acgggccgaa ctctgcagtg ttccagcagg cggaaaaccg tcttcatgtg caaaaagcac 1174861 tgctgaaggc cattttatat aaaggggaat catcaaaaaa ctgctgagcc aaactcagca 1174921 gtttttttga tggcaacata ttcacagccg cttaggcgca tactacagca aaaaggaaaa 1174981 ggaggaaaaa cagtgggaca gcagcaccaa ttccggcccg gacagaaagc gcctaataac 1175041 ggtgtctacg tagaaatcgg cgagacaggg agcatggtta aaaaccctca aaaggtccat 1175101 ctgtcagcag gggaaatgtt ccccgaaaca tcaaaccaca accggctgtg gacctacaaa 1175161 agaaagccgt gaccactaaa aaacccaaaa caataaatgt tttgggtttt tggcttttta 1175221 atgctggctt gcatttttgt tcataggcat gatttctgct aaaaccatga ttaagacata 1175281 cagtacaaca gcaatgacag atgatgtttt gaaattatac gtaacgctgt tcatgcttgc 1175341 aaccaagtag catgccatat gtgataaaag gaacgtccaa ataaaggcaa taatatatcg 1175401 cacgtttcca cctcgtcctt ctcattctat tctaaaagtt atcataccat acaaaaagcg 1175461 aagggggaat ccaattttag cagaaagtga ggtgacaaaa gagtctgatt cgtcacactt 1175521 taatggtaaa atataaaacg tcaatcagta taatagccaa aaatgtaaaa ggctaggact 1175581 ttaccttatt cgtttctttt ctatttacat aagatagcgt gagatgaagt gtgaaaggag 1175641 gcgggcaagc gatgggaata acggaaagat actttcaact gggaacggag cataatgtca 1175701 ttcatctgcc ctatcgcccg aacggcttcg gcatctttat cttgggggac agaacccact 1175761 ttgtcggaca tgattcaagc ttttggcagc agcattatgg cagaaatcag cttctgagca 1175821 tgttgatgaa tgaaggatac actcttttta acagcaatct gttcggaagg cattgggggg 1175881 cggaaaaagc agtcacctat gccaaacagc tgatacattc tgtgctgaag caggaaatcc 1175941 tcaatccgaa gattcatatt ttagcagaag gcatgggtgc tctcgtggcc gatgaactgc 1176001 ttcgtttttc cccggatcat atccgctcag ccgcaatgtt gaatccttgt ctcgatcttc 1176061 aggcacatta tgaatcggaa aaagaaaata aatttttcta taagcaattt ttgaaagaag 1176121 tatcgaaaag ctacggaatt tctgaaaaag aagcggaagc gattcgttat aaaacaattc 1176181 aaagctaccc gagcggcgta ccggttcata tatggcagcg tatgaccgga gctccatatc 1176241 cctacagcgt acatgcggaa gttttcaagg aaaaacagca aaagcaaggc tcaccggtcg 1176301 acatgacatt tcatttattt gagcatccaa gcagaattta tgcatcaatt tgcaaattct 1176361 ttcatagtca tgaaaaagaa ttatagagaa tataatgaca acagccttct cttttgcgga 1176421 ggctgttttg ttttgggaaa tgaaaaaccg gaagggcggc agatgcaatg gaatcaacgc 1176481 tgattgtagg tgcggacgaa tttttcggcc tttcattatg tgagcgaatg atggatgaag 1176541 gcatacatgt tgacgttgtt ctggcggaaa cagaagataa aatgagacaa atgtacttag 1176601 aagaaagact catgtggctt gggagaaatg aactctttcg ccagcttgaa cacattggag 1176661 accaaaatta tgatacaatt tgtatccagt tcggaagttt tttgccttta gaccaatatg 1176721 attctcctta tattttagta tatgaagaag accgaaaaga atgggataaa cgtgaaaaaa 1176781 caggctcgga aaaaaccgtg atcctgccga aaatgtacgg gccatggaaa gaagaaacag 1176841 aggaagacgg ctattacaca aacgacgtgg ctgacgagtt gctgagattc ctgttagaac 1176901 caagccgtca tagcaaagat cagctttttg aattgcaagt cacagagaaa acctcaaaag 1176961 aagaagcaaa aacaaaaatt atcgagtgga aaagacaatt ttcatcaatt ttcgacaaat 1177021 attaagaaaa accttccatg tttcgagttt tctagataca ataaacgtat aaaaataata 1177081 catgttatag cttgtcaaaa ggagttgaac atgacttgat cacaaggctt gtcatgatct 1177141 tttctgtcct ccttttattg agtggatgtg gacaaactcc gttcaaagga aaaattgaga 1177201 aggtcggcat gctctttcct gatacgatta atgacctcgt atggggcaca aaagggtata 1177261 aaggattact gaatatacaa tccaaataca atgtggacgt ctattataaa gaaggcgtta 1177321 aaacagaaga agatatcata aatgcgattg aggattttca taagaggggc gtcaatctgc 1177381 tctacggcca tgggagtgaa tatgctgagg tgtttaactt ggtcggcgaa gattatccag 1177441 atatggaatt cgtcatttcc aatgcgaaag cgaaagctga taatgtaaca agtgtccatt 1177501 ttagcgggga agcaatgggc ttttttggag gaatgactgc tgcccatatg tcgaaaacga 1177561 atcaggtcgg tgtaattgct tcctttacgt ggcagcctga ggttgacggt tttatcaaag 1177621 gggccaagta tgaaaatccg gatatagagg taaatacgaa atatacggat cattgggatg 1177681 atgatacaac agcagtaaag ctttatcaga aaatgaagaa cgaaggcgcg gatgttgtgt 1177741 atcccgccgg agacgggtat aatgttcctg ttattcagca aatcaaaaaa gacggtcttt 1177801 atgccatagg ctacgtcaca gatcaatcgg atctgggcga gaataccgta ttaaccagca 1177861 cggtgcaaaa tgtggacaag gcctatgaaa tcattgctga acaatttaat aaaggcaccc 1177921 ttgagggcgg cgatcattac tacgacctga acacgggagt cgttgagatg ggaacattca 1177981 gcccgctcgt cgatcaagac tttcagcaaa gaatcgccaa gctgatcaaa acatacaaca 1178041 aaacaggcga gctgccaaaa aacgagtaat ggagtgacgt cacatgcagc acgaaaaatc 1178101 acttgaattc ttgcaaattg ccatgaaata tctccctgaa gcgaaagaac agcttgagaa 1178161 atcaggcatt gagctctcaa tggaggccat ccagccgttt atgaatctat ttacaacggt 1178221 aatggcggaa gcttatgagc ttggcaagtc tgacgctaaa tctgaaacag aataagaaga 1178281 agccactttt ttgaaagtgg cttttcacat gattttcttt ttaatagcgg agagcatggg 1178341 cgcaagctcc tttaaagcgg gcttgatttg atcaagagag ttcataattg aaccgatttg 1178401 gtccataata tgcatgtaat taatcgtctc ttcgtcgttt gtctgagaaa cctgagaaac 1178461 ttcctcttgc tgttcctcct ccttctcttc tgttggtttt gctgcatcgc cgaacatcat 1178521 tcttgaaaac acatccaact gcatacgcct cctttccata taccatactc tatgagtaag 1178581 atgaactgat agtttagacg aatatattgc catgtgaaaa aaaataggat agaattagta 1178641 cctgatacta ataattgatc acaacctgat tgatcttcta aatttaagat ataaaggagt 1178701 cttccctaat gaaagctgga atacttggtg ttggacgtta cattcctgag aaggttttaa 1178761 caaatcatga tcttgaaaaa atggttgaaa cttctgacga gtggattcgt acaagaacag 1178821 gaatagaaga aagaagaatc gcagcagatg atgtgttttc atcacatatg gctgttgcag 1178881 cagcgaaaaa tgcgctggaa caagctgaag tggctgctga ggatctggat atgatcttgg 1178941 ttgcaactgt tacacctgat cagtcattcc ctacggtctc ttgtatgatt caagaacaac 1179001 tcggcgcgaa gaaagcgtgt gctatggata tcagcgcggc ttgtgcgggc ttcatgtacg 1179061 gggttgtaac cggtaaacaa tttattgaat ccggaaccta caagcatgtt ctagttgttg 1179121 gtgtagagaa gctctcaagc attaccgact gggaagaccg caatacagcc gttctgtttg 1179181 gagacggagc aggcgctgcg gtagtcgggc cagtcagtga tgacagagga atcctttcat 1179241 ttgaactagg agccgacggc acaggcggtc agcacttgta tctgaatgaa aaacgacata 1179301 caatcatgaa tggacgagaa gttttcaaat ttgcagtccg ccaaatggga gaatcatgcg 1179361 taaatgtcat tgaaaaagcc ggactttcaa aagaggatgt cgactttttg attccgcatc 1179421 aggcgaacat ccgtatcatg gaagctgctc gcgagcgttt agagcttcct gtcgaaaaga 1179481 tgtctaaaac tgttcataaa tatggaaata cttctgccgc atccattccg atctctcttg 1179541 tagaagaatt ggaagccggt aaaatcaaag acggcgatgt ggtcgttatg gtagggttcg 1179601 gcggaggact aacatggggc gccattgcaa tccgctgggg ccgataaaaa aaggtgaggt 1179661 gcacacaaga tgactaaaaa aagagtagtt gttacaggac ttggagcatt atctccactt 1179721 ggcaacgacg tcgatacaag ttggaataac gcaatcaacg gtgtgtccgg aatcggtccg 1179781 atcactcgtg ttgacgctga agaatatccg gcaaaagttg ccgctgaatt aaaagatttt 1179841 aatgttgaag attatatgga taaaaaagaa gccagaaaaa tggaccgctt tacacaatat 1179901 gcggttgtgg ctgcgaaaat ggcggttgaa gatgcagatc ttaacattac cgatgagatc 1179961 gcgccgagag tcggtgtttg ggtaggctcc ggtatcggag gacttgaaac actagagtct 1180021 caatttgaaa tcttcttaac aaaaggccca agacgggtaa gcccgttttt cgtgccaatg 1180081 atgattcctg acatggcgac aggccagatt tctattgcat taggagcaaa aggggtgaac 1180141 tcttgtacgg ttacagcatg tgctacagga acgaactcca tcggtgacgc gtttaaggtt 1180201 attcagcgcg gtgatgcaga cgtgatggtc acaggcggaa cagaagcgcc gctgacaaga 1180261 atgtcattcg ccggctttag tgccaacaaa gcgctgtcta ctaatccaga tccgaaaaca 1180321 gcgagccgcc cgtttgataa aaaccgtgat ggctttgtca tgggggaagg tgcagggatt 1180381 atcgttcttg aagaacttga gcatgccctg gcccgcggcg ctaaaattta cggagaaatt 1180441 gtcggctacg gctcaaccgg agacgcttat catatcacag cgccggccca agacggtgaa 1180501 ggcggagcga gagcgatgca agaagccatt aaagatgcag gcattgcacc tgaagaaatt 1180561 gattacatca atgctcacgg gacaagcacg tattacaacg acaaatacga aacaatggcg 1180621 attaagaccg tttttggcga gcatgcgcat aaacttgcgg taagctctac aaaatcgatg 1180681 acaggccacc tcttaggagc agccggcggt attgaagcca ttttctctat cctggccatt 1180741 aaagaaggcg tgattccgcc gacaatcaat attcaaacac ctgacgaaga atgtgatttg 1180801 gattatgtgc ctgatgaagc ccgcagacag gaacttaatt atgttctcag caactcatta 1180861 ggattcggcg gacacaacgc aacattaatc tttaaaaaat atcaatcata atcaagccaa 1180921 accggctgcc cttaaagggt agccggtttt ttttgtgtgc ataggattaa aagaggaggc 1180981 gatcacatga gtgtagaaca aacatatagc tggctcagga aggccggttc aatagatgat 1181041 ttggcgcatt acattatccc gcttttttca ggtgcggaga aaaagaactg gaagggcatt 1181101 ctggggcatc ttcagcatca tgggatgttt aaaaacataa aagagggtat tcagacggtt 1181161 tccaagctga aggaaaaagg tttttacgga catatccaaa aggaagaaca gtacctcaaa 1181221 aacaaatggc aaggtcctga tgtaccaatt gttacgctgc cggttgatga acgaaacagg 1181281 agaatccgtt tagaattcgg atcaaaatca ggactcgcct ttcaagacaa aatgttcctt 1181341 tttctttcgt cagatttaga ttttgggtcg gtatctgccc ttatgacgca tgagtatcat 1181401 cacgtttgcc ggttaggtca tctgacaaaa gaggaaaagg atgtcacatt acttgataca 1181461 atcatcatgg aagggctggc ggaatatgct gtttatgaga ggttcggccg aagtcaaacg 1181521 gctgaatgga cgacttggta tacaccggaa cagcttcagg ctttatatga aaaaaagatt 1181581 gcgccccatc gggatatcaa acgggataat cgattatttc cccagctgtt attcggcaaa 1181641 ggatatcagc caaaaatgct tggatacgca gttggattca atattgtaaa aaaatattta 1181701 accgccagca aggcaagcac cgcagacggg ctgtccattc ctgctgagac ctttttggat 1181761 gcaatgcttt aaaaggataa aataatggaa tttcattaat aatattacat ttatcctaaa 1181821 aaattcttga ttttgcaaaa tgattgtaat aatatacaac tataaaattt ttcgataatt 1181881 caatattatt tattatttct gaataaaggg attgctttct cttgaaaacg tttgacaaca 1181941 agagggggga aaggggagct agcatgagca cacttttaga agtgaataat ttaaagactt 1182001 attttttcag gaaaaaggag ccgatccctg cggttgacgg agtcgatttt cacatcagca 1182061 aaggcgaaac cgtcgcgctt gtaggtgaat cgggctccgg aaaaagcatt acttctttat 1182121 caattatggg cctcgtccaa agctcaggcg gaaaaatcat ggacggctct attaaactcg 1182181 aagacaaaga cctcacctca ttcactgaaa acgattattg caaaatccgc ggtaacgaag 1182241 tatccatgat ctttcaggaa ccaatgacct cccttaatcc ggtgttaaca atcggagaac 1182301 aaattaccga agtgctgatt taccataaaa acatgaagaa aaaagaagcc cgtcaacgag 1182361 ctgttgaact cttgcagatg gtcggtttct cccgggcgga gcaaattatg aaggagtacc 1182421 cgcatcggct gtccggcggt atgagacaga gggtgatgat tgccatcgca ctgagctgta 1182481 atcctaaact gctcattgct gatgaaccaa cgacagcgct ggacgtgaca atacaagccc 1182541 aggtgctgga gctcatgaaa gatctctgtc agaagttcaa tacatcgatt cttctcatca 1182601 cacacgactt aggtgtcgtg tctgaagctg ccgatagagt gattgtcatg tactgcggac 1182661 aagtcgtaga aaacgccact gttgatgact tatttttaga accgcttcat ccgtatacag 1182721 aaggcctgct tacgtcaatt cctgttatag atggagagat tgataaatta aatgcgatta 1182781 aaggcagtgt gcctacaccg gataatctgc cgccggggtg ccgttttgcc ccaaggtgcc 1182841 cgaaagctat ggataagtgc tggacaaatc agccttcgct tttgacacac aaaagcggaa 1182901 gaacggtgag atgcttttta tatgaggaag agggtgccga acaatcatga cagcagctaa 1182961 tcaagaaaca atcttagagc ttcgtgacgt aaaaaaatac tttccgatcc ggtcaggcct 1183021 ttttcaaaga aaagtcggtg atgtaaaagc ggtggatggt gtttcatttt cgttaaaaaa 1183081 aggagaaaca ctcggaatcg ttggagagtc gggctgcgga aaatcgactg ccggcagaac 1183141 gatgatcaga ctgtacaaac cgacagaggg ccaaattctt tttaaagggc aggatatttc 1183201 caatctgtca gaggagaagc tgcggaagag tgtccgcaaa aatattcaaa tggttttcca 1183261 agatccattt gcttcgttaa acccgagaaa gaccctgcgt tccatcataa aggagccgtt 1183321 taatacgcac aacatgtata ccatgcgtga acgaaacgaa aaagttgaag agctgcttgc 1183381 aagagtaggg cttcacccgt cgtttgccgg ccgttatccc catgagtttt caggcggcca 1183441 gcgtcagcgg atcggcattg ccagagcact cactttgaat ccagagctga tcattgcaga 1183501 tgagccggtt tccgcacttg atgtatccat tcaggcccaa gtgattaact tgatggagga 1183561 attacaggaa gaatttaatc ttacgtatct atttatctct catgatctga gtgtcgtccg 1183621 ccatatcagc gacagagtcg gagtaatgta tcttggcaaa atgatggaac tgaccggcaa 1183681 gcatgagctt tatgacaacc cgcttcaccc atatacccaa gcgcttttat cctccgttcc 1183741 ggttacaaga aaaagaggtt ctgtcaaacg tgaacgcatt gtcctgaagg gagaactgcc 1183801 tagtccggcc aacccgccaa aaggctgcgt attccacaca agatgtcctg ttgcaaaacc 1183861 gatatgcaag gaacaaatac cagaatttaa agaagctgct cccagccact ttgtggcttg 1183921 tcacctttat agctaatgtt gcccgcacag ctttgagagg gggtatgcac actacataaa 1183981 caacagccta gaagaacgaa catttcaaga gggggaatat ctaatgaaaa gacggaaaac 1184041 cgcactgatg atgctaagtg tattgatggt tctggccatc tttttatcag cctgctcggg 1184101 atcaaaatca agcaacagca gcgcgaaaaa atcagcaggc aaaccgcagc aaggcgggga 1184161 tttggttgtt ggttcaatcg gagaacccac actttttaac tctctgtatt ctaccgatga 1184221 cgcaagtacg gatattgaaa atatgctgta cagcttttta acgaaaacgg atgaaaaact 1184281 aaatgtgaaa ttgtcactcg ctgaaagcat taaagaatta gacggcggcc ttgcatatga 1184341 tgtgaaaatt aaaaaaggcg ttaagtttca tgacggaaaa gaactgactg cagacgacgt 1184401 cgtatttacg tacagtgtcc ctttaagcaa agattacaag ggagaacgcg gttcaacata 1184461 tgaaatgctg aaatccgtag aaaaaaaggc gattacgaag tcttgtttaa gctgaaatat 1184521 aaagacggta atttctacaa caatgcgtta gacagcacag ctattctgcc gaaacatatt 1184581 ctcggtaatg ttccgattgc tgatttagaa gaaaatgagt ttaacagaaa gaaaccaatc 1184641 ggttcaggac catttaagtt taaggaatgg aagcagggcc aatatattaa gctcgaagcg 1184701 aatgatgatt actttgaagg aagaccgtat ttagatactg tgacgtataa agtcattcct 1184761 gacgcaaatg ctgccgttgc tcagctgcag gcaggcgata ttaatttctt taatgtgccc 1184821 gccactgact acaaaacggc tgaaaaattc aacaacctaa aaatcgttac tgatttggca 1184881 ttaagttatg tgtacatcgg gtggaatgaa aaaaatgaat tattcaagga taaaaaggtt 1184941 cgtcaagcgc taacaaccgc tcttgaccgc gagtcaatcg tcagccaagt attagatgga 1185001 gacggcgagg tagcttacat tccggaaagc cctttatctt ggaactatcc taaagatata 1185061 gatgttccga aatttgagta caacgagaaa aaagcgaaac agatgcttgc agaagccggc 1185121 tggaaagata cgaacggtga cggcattctg gataaagacg gaaagaaatt ctcgtttacc 1185181 cttaaaacga accaaggaaa caaagtccgt gaagacatcg ctgtcgtcgt tcaggaacag 1185241 ctgaaaaaaa tcggcattga agtgaaaacc cagatcgttg aatggagcgc tctcgttgaa 1185301 caaatgaatc ctccgaattg ggattttgat gcaatggtca tgggatggag tttatccaca 1185361 ttcccggatc aatatgatat tttccattca agccagatta aaaagggttt gaactacgtt 1185421 tggtataaaa atgccgaagc ggataaactc atgaaagatg caaaatcaat cagtgacaga 1185481 aagcagtatt caaaagaata tgagcaaatc tatcaaaaaa ttgcggaaga tcagccgtat 1185541 acgttcttgt attatcctaa caaccatatg gcaatgccgg aaaatcttga aggatacaaa 1185601 tatcatccga aacgtgattt gtataatatt gaaaaatggt ggcttgcaaa ataaatttcc 1185661 cttaaagggg agggagagcg ttttctccct cttctgtttt taataaggaa agtaaagggg 1185721 gacaagtata tggctgcata tattatcaga agaaccttaa tgtctatccc gattttattg 1185781 ggaattacga ttttatcatt tgttatcatg aaagccgcgc ccggagatcc gatgacatta 1185841 atgatggacc cgaaaatcag ccaggctgac agagagcagt ttattgaaaa atacggtctg 1185901 aatgatcctc agtacgttca atatttaaag tggctaggca acatggtgca gggtgatttc 1185961 ggaacgtcta ttgtcagaaa aggaacgcct gtttcagaat tgattatggc aagactaccc 1186021 aatacgctcc tgctgatgct ggtttcaacg attttggctc ttatgatttc tattccgttc 1186081 ggtgtcctgt cggcaaagcg gccgtattca aaaatcgact atggcattac atttacctcg 1186141 tttataggcc tggctattcc aaacttttgg tttggattaa ttttgattat ggtgttatcg 1186201 gtaaatctcg gctggtttcc aactgggggt gtcgagacac tgaataccga attcaatata 1186261 tttgaccgga ttcatcattt aattctgcct gcattcgttc tagctacagc tgacatggcc 1186321 ggactgacga gatacacgag atccaatatg cttgatgtat taaatcaaga ttatattcgc 1186381 acagcgagag caaaaggatt taaagagaac agagtgctat ttaaacatgg attgaggaat 1186441 gcattattac ccgtcattac aattttcggt ttgatgattc cttcatttat cggcggatct 1186501 gtcgttgtcg aacaaatttt cacttggccg ggattaggaa agctgtttgt cgattcagca 1186561 ttccagcgcg attatccggt tatcatggca atgactgtga tctcggcggt tcttgtcgtt 1186621 gtcggaaacc tcattgcaga catcctttac gcgattgttg atccgcggat cgaatattaa 1186681 aaggagggaa acagagatgt cagagctgca aacaactccc tcgccggaga tcaggctgaa 1186741 agaaaatatt tcgaaaaagc cagaaacaat gacaaagatt ttctgggaaa aattctcgaa 1186801 aaacaaactg gccattttag gtgccgttat tctttttatc attattatgt ctgctgtttt 1186861 cgccccttta attgcacctt atccccaaga gcagcaaagc ctgcttgata aatataaggc 1186921 gccgggcctt gaacatctga tgggaacgga taaatttgga cgtgatattt tcagccggat 1186981 cctatatgga gcgcgtgtct ctttattggt tggatttgcg tccgtagtcg gttcgatttt 1187041 gatcggaacg gttttaggag cattagccgg atatttcaga ggaatagtgg atgctgtcat 1187101 tatgcgtgta gttgacattg tgttatccat tcctgatatt ttcttgttga tcacgctggt 1187161 caccatcttc aagccgggtg tggacaaatt gattttaatt ttctgtctca caggatggac 1187221 cacaacagca cgattagtaa ggggagaatt cttgtcgctc cgttcaaggg aatatgttct 1187281 tgctgctaaa acaattggaa caaaaacgca caaaattatt ttttctcata tcctgcccaa 1187341 tgcgttaggg ccgattatcg tgtcagctac gctgaaagtt gggtctgtta ttctagctga 1187401 atcggcgcta agctacttgg gctttggaat ccagccgcca atcgctagct gggggaacat 1187461 gcttcaagac gcacagaatt tcacagtaat gattcaagca tggtggtacc cgttatttcc 1187521 cgggctattt attttaatga ccgttttatg cttcaacttt gtcggtgatg gcctgcggga 1187581 tgcgcttgac ccgaaaaata ttaaataaaa atgaatatca tatctgttat aaaatatcac 1187641 caaatcagaa aaaagcaggt ctcctttagt cagaaaatat acaaagagat ctgcttttta 1187701 tgattcttac ataaacccag tgattccaga tttcctcaat ctctttggaa taatttctct 1187761 atcccttgcc tatactgtgg acaacagttt ttataaaagt gaggggttag agatgttatt 1187821 tcttcatgat gtgtgggtca attggtttga aggggaagaa aatggctaca atgtatgcca 1187881 ctttcacgaa tggcgcaagg aagatacggt tgagcttttg gatcaggtgc cgctgttaag 1187941 ggtgccgtca gtactgtttc attacataga aaacgatttg tcagagcttc cgaaaggttt 1188001 gcttgaagac gtacatcaga aatcgtacat tcgaaaaaat catgagcgga caaagcttga 1188061 gtattgtttt gtcgtaacag acggaatcgg cattttagct gttgacacga tcggctacac 1188121 gatccctgtc agaaaaagcc gtctaatccc aagacaggag cagctcgttt atgaaatggt 1188181 aaaagatgta gagcctgaaa catatgaatt tgagccaaag aagctggaat cctccaagga 1188241 atatcacatc ttatcattag caccagaaca tgtcagagga ctgacaagaa aagaacggca 1188301 aattaagcag ctgatgttta tggcgcttga ccaattaaaa gggctgaaaa accgagcgga 1188361 aattggctac tggtacacag agtggaatcc gcatatgtat gaacaaatca aaaggatgag 1188421 ctttgaagag atttgggaca tgctgtataa cgaaacaatt gaaggctggt cggacaaaca 1188481 cctagctttt tgcgaaaacc taataaaagg acagcctttt ttcgaaaagc tttgggaaat 1188541 ggaaaacgaa tcaaaggtca actgaaaaaa accgctcttt gcaaagagcg gttttttgat 1188601 tagcgtcttt ttcttccaag acccatggca ttctccattt ttttcagcat tttgtttgct 1188661 gtccgattcg ctcgttccgc gccttcatca agaatccggt ctaattcttc agattctatc 1188721 agctcgtaat agcggtcctg gatcggtttt aatgcgttca ctacgacttc tgccaaatca 1188781 cctttaaact cgccgtagcc ttttccttcg tactttgctt caagctcttc aattgtcgta 1188841 ttgccgagga ttgaataaat tgtaagaagg ttggaaacgc ccggtttgtt ttccttatca 1188901 aatttgacaa tgccttcaga atccgttact gcgcttttga ttttcttttc aagctgcttc 1188961 ggctcatcca gcaatgtaat ataagctttc tgattcggat cagatttgct cattttcttc 1189021 agcggatcat tcagagacat gatacgtgca ccgacttttg gaattttcac ttccggaatc 1189081 gtaaagatgt cgttgtattt tttgttgaag cgttctgcaa gattccgcgt cagctcaagg 1189141 tgctgctttt gatcctcgcc gacaggtaca agatccgttc cgtacagcag aatatcagcg 1189201 gccatcagcg gcggatatgt taacaggccg gagacgacag cttcattgcc tttggatttg 1189261 tccttaaatt gagtcatccg ctcaagctcg ccgatatagg cgacacactg catcatccat 1189321 ccggcctgcg catgtgcggg gacctctgac tgaataaaca atgttgcttt ttctggatca 1189381 agtccgacag ctaagtaaag cgccgcgaga ttgcggatat tctttctaag ctcaagccgg 1189441 tcttgaggaa cagttatcgc atgctgatcg acgatgcaaa aatagctgtt ataatcatgc 1189501 tgcagttcga caaactgctt cattgcaccg atatagttgc cgagcgtcac tgagccgctt 1189561 ggctgaatgc ctgaaaaaat cgtttgtttc atgaaaacat caacctcatt tcttaaaaca 1189621 taataaaaaa ggctcattct tcccctgtaa aaaagggacg aatgaaccgt ggtaccaccc 1189681 tgattattcc attaaaatgg aatcactctg acgtttgtaa cggagactgc tccggctgag 1189741 cctacttttt tccagttcgg tcagctgctc caaagtccat tccacattgc ccgttatctg 1189801 ctcccagcac cgcagactct cttcaaacag gtgaaacgtg tactactctt tttcatagca 1189861 agcttttctt ttgattgctt cattataaat caattataac caattgtcat catgaaaaaa 1189921 cattcttttt tccagtaaaa ttgtaataat ataaataaca cgagtgctgt aaaatcctta 1189981 aatgataact gctatcagcg taaaaacagg cagatattat atgtaaaaag caatatgggc 1190041 agaaaacaca tgaaaaagtt tttaatcaat ttatgcttta aatggtagaa ggatattatg 1190101 ttcatggaag aaaaactaac gaagtttaaa tattttaaat tgataaaata atattgcaat 1190161 aaattatttg tttcattata atgaacttgt tcactctatt gttacagctt ttttacaaaa 1190221 ataatcagaa aagacggaac agaataaaag ttgtggaaac tcaggttcat ttgtctgata 1190281 tttctgagga tttagccgta aggagctgaa aattattatt agggggtttg cgaatatgaa 1190341 aaaacgttgg tcgattgtca cgttgatgct cattttcact ctcgtgctga gcgcgtgcgg 1190401 ctttggcggc agcggatcaa acggtgaagg gaaaaaggac agtaaaggaa agacgacact 1190461 taacattaat attaaaactg agccgttctc cttacatccg ggattggcaa atgattcagt 1190521 atcaggcggt gttatccgtc agacttttga aggattgaca cgtatcaatg cagatggtga 1190581 gcctgaagaa ggcatggctt ctaaaattga aacgagcaag gacggaaaga catatacatt 1190641 taccattcgt gatggtgtga aatggtctaa tggagaccct gtaactgcac aagattttga 1190701 atatgcttgg aaatgggcgc ttgaccctaa taatgaatca caatacgctt accagctcta 1190761 ctacataaaa ggtgctgaag cggcgaatac cggaaaaggc agcctagacg atgtggcagt 1190821 aaaagctgtg aatgacaaaa cgctgaaggt tgaattaaat aacccgactc catatttcac 1190881 tgaattaact gcgttctata cgtatatgcc gatcaataag aaaattgcag agaaaaataa 1190941 aaagtggaat acaaatgccg gagatgatta tgtatcaaac gggccgttca aaatgacggc 1191001 atggaaacac agcggctcta ttactctcga aaaaaatgac cagtattggg ataaagacaa 1191061 agtcaaactg aagaaaatcg atatggttat gatcaacaat aacaatacgg aactaaaaaa 1191121 attccaagct ggcgaacttg attgggccgg tatgccgctc ggacagcttc cgacagaatc 1191181 cctgccgacc ctgaaaaaag acggttcttt acatgttgag ccgattgcag gagtgtattg 1191241 gtacaaattc aacactgaag ctaagccatt agacaacgtc aatatccgta aagctttaac 1191301 atattcgctt gaccgtcagt cgattgttaa aaacgttacg caaggagagc aaatcccggc 1191361 aatggctgca gtgccgccta caatgaaggg atttgaggat aacaaagaag gatacttcaa 1191421 agacaatgat gtcaaaacag caaaagaata ccttgaaaaa ggcctaaaag aaatgggctt 1191481 aagcaaggca tctgatttgc caaaaatcaa attgtcttac aacactgatg acgcacacgc 1191541 gaaaatcgct caagcagtac aagaaatgtg gaagaaaaat ttaggcgttg atgttgagct 1191601 tgataactca gagtggaatg tctatattga taagctccac agccaagatt atcaaatcgg 1191661 ccgtatgggc tggctcggcg acttcaatga tcctatcaac ttccttgaat tgttccgcga 1191721 caaaaacgga ggaaataacg atacaggctg ggaaaatcca gaattcaaaa agcttctgaa 1191781 tcagtcacaa actgaaacag ataaaacaaa acgtgcagag ctgctgaaaa aagcagaagg 1191841 tattttcatt gatgaaatgc cggttgcccc aatctatttc tatactgata cttgggtaca 1191901 ggatgaaaac ctaaaaggtg ttatcatgcc aggtactggt gaggtttatt tcagaaacgc 1191961 atattttaaa taaggctacg tctgaaaata aaagacctca aggtatatgg ggagaaaagc 1192021 cccatatacc tttcttactg atggagtata aaaatgtaaa aaccatggag gtgttccccc 1192081 ttgctaaaat atatcggaag acgcttagtc tatatgatta tcacactatt tgtgattgta 1192141 actgtgacat tcttcttaat gcaagcagca ccgggcgggc cattttcagg tgagaaaaag 1192201 cttccgcctg aaattgaagc aaatttaaat gcgcattatg gcttggacaa gccgctgttt 1192261 gtacaatatg tcagttattt gaaatcagtt gcaatgtggg atttcggacc gtcatttaaa 1192321 tataaaggtc agagtgttaa cgacctgatc agttcaggtt tccccgtttc atttactctt 1192381 ggagcagaag ctattctcct cgctttagcg ttaggtgtat tgtttggggt cattgcagcc 1192441 ctttaccata ataagtggca ggattatacc gtcgcgattt taacgatatt tggtatttcg 1192501 gttccgagct ttatcatggc ggctgttctg caatatgtgt tctccatgaa gcttgggctg 1192561 tttccggtcg cggggtggga ttcctgggca tacacctttt tgccttccat cgcacttgct 1192621 tccatgccga tggcgtttat tgccagactt tcccgttcaa gcatgatcga agtgttaaac 1192681 agtgattata tccgcacagc gaaagcgaaa gggctttccc gcccagcggt tacagtgcgg 1192741 cacgccattc gaaacgcact tttgccggtt gttacatata tgggcccgat ggccgcacag 1192801 gtcttaacgg ggagcttcat tattgaaacc atttttggga ttccggggct tggtgcacac 1192861 ttcgtcaaca gtattacaaa ccgtgattat acggtcatta tgggtgtaac ggtgttcttc 1192921 agtgtcatct tgctattgtg tgtattaatc gtagatgtgt tatacggcat tattgatcca 1192981 agaatcaagc tttccaaagc aaagaaagga gcctaggcca tgcagaacat tccaaaaaac 1193041 atgtttgaac cagccgcagc gaatgccggc gatgcagaaa aaataagtaa aaagagcctt 1193101 tccctctgga aagatgcgat gcttcgcttc cgcagcaata agcttgcaat ggtcgggctt 1193161 atcattatcg tacttattat ccttatggca atttttgcgc cgatgttctc aaggtatgat 1193221 tattcaacta ctaatctctt aaatgcggat aagccgcctt caaaagatca ctggttcgga 1193281 acagatgatc ttggacggga cattttcgtc cgtacatggg taggggcgcg aatctcaatc 1193341 tttatcggtg ttgcagctgc tgttctcgat ttgctgatcg gcgtcatttg ggggagcatt 1193401 tcaggcttcc gcggaggaag aacagatgaa atcatgatgc gtatcgctga tatcctttgg 1193461 gcagttcctt cattattaat ggttatctta ctgatggttg ttcttccgaa aggtctattt 1193521 acgattatta ttgccatgac gattacaggc tggattaata tggccagaat cgtgcgcgga 1193581 caagtgctgc agctgaagaa tcaggagtat gtgcttgctt cacagacact gggtgcaaaa 1193641 acatcccgtc ttctatttaa acatatcgtg ccaaacgcaa tgggttctat tttggtcacg 1193701 atgacactga cagttcctac tgcgattttt acagaagcct ttttaagcta tttgggactt 1193761 ggtgttccgg ctccgctggc aagctgggga acgatggctt ctgacggatt gcctgcattg 1193821 acctattatc cgtggcgttt attcttccct gccggattta tctgcattac aatgtttggt 1193881 tttaacgttg tcggcgacgg attaagagac gcattggatc ctaagttacg taaataaggg 1193941 agtgatacgg gtgacacgcc tattagaagt aaaagattta gcaatttcat ttaaaacata 1194001 tggcggagag gtccaggcga tccgcggagt gaatttccat ctggataaag gggagacgct 1194061 ggccattgtt ggagaatcag gttccggaaa aagtgtaacc tctcaagcga ttatgaagct 1194121 gattccaatg cctccgggtt atttcaaacg cggtgagatc ctgtttgaag gaaaggatct 1194181 ggtgccgctg tccgaaaaag aaatgcaaaa tgtccgggga aaagagatcg gcatgatatt 1194241 ccaagatccg atgacctctt taaatccaac gatgaaggtc ggtaaacaaa ttacggaagt 1194301 gctttttaaa cacgaaaaga tctcgaagga agcggctaaa aaacgcgcgg ttgaactgct 1194361 ggaattagtc ggtatcccaa tgccggaaaa gcgggtgaac caatttccgc atgaattttc 1194421 aggcgggatg agacagaggg ttgtcattgc catggcgctt gcagcgaatc cgaaacttct 1194481 gatcgccgat gagccgacaa ctgctcttga tgtaacgatt caagcgcaaa ttttggaatt 1194541 aatgaaggat ttgcaaaaga aaattgacac gtccatcatc tttatcacac acgatcttgg 1194601 tgttgtggct aacgttgctg accgggtcgc tgtcatgtac gcgggacaga ttgtagaaac 1194661 tggtacggta gacgaaatct tctacgaccc gagacatccg tacacttggg ggcttcttgc 1194721 atccatgccg acactggaaa gttcaggaga ggaagagctg actgcaattc cgggcacgcc 1194781 gcctgatttg acaaacccgc caaaaggaga tgcttttgcc ctgcggagct cttacgcgat 1194841 gaaaatcgat tttgaacagg agccgccaat gtttaaggta tccgatactc attatgtaaa 1194901 atcgtggctg cttcatcctg acgcgccaaa ggtagagccg cctgaagcgg taaaagcgaa 1194961 aatgcgtaaa ctggcaaaca cgtttgaaaa acctgtctta gtgagagaag ttgaatgaat 1195021 tgactgaaaa actattagaa atcaaacatt taaaacagca ctttgtcacg ccgaggggaa 1195081 cggttaaggc tgtagatgat ttatcatttg atatctataa aggtgaaaca ttagggctgg 1195141 ttggtgaatc tggctgcggt aaatcgacaa caggccgaag cattatcagg ctgtacgaag 1195201 caaccgatgg tgaggtgctg ttcaacggcg aaaatgtgca cgggagaaaa tcgcggaaaa 1195261 agctgctgga attcaaccgc aaaatgcaga tgattttcca agacccctat gcatccctga 1195321 atccgagaat gacagttgct gatattattg ctgaaggcct tgatattcat aagctggcaa 1195381 aaacgaaaaa agagcggatg cagcgagttc atgaactatt ggaaacagtg ggattgaaca 1195441 aggaacacgc gaaccgctat cctcatgaat tttccggcgg ccagcgccaa agaatcggga 1195501 ttgccagagc gcttgctgtt gatccggaat tcattatcgc ggatgagccg atttccgctt 1195561 tggatgtatc cattcaagcg caggtcgtga atttaatgaa agaactgcaa aaagaaaaag 1195621 ggctcacata cctgtttatt gcccacgatt tatcgatggt caaatacatc agtgaccgca 1195681 ttggcgtcat gtatttcggg aaactggttg agcttgcgcc ggcagatgag ctttatgaaa 1195741 atccgcttca cccatataca aaatcattgc tttctgcgat tccgcttcct gatccggact 1195801 atgagagaaa tcgcgttcgc cagaaatatg atccgtctgt ccatcaatta aaggatgggg 1195861 aaacgatgga attccgtgaa gtcaaaccgg gacattttgt gatgtgcacg gaagccgaat 1195921 ttaaagcttt ttcatgattc atcaatcctt caagagattt ctcttgaagg atttttttgc 1195981 gtcttcatag aaagtgagaa tgataacatt tacaattaga ggaaaaagcg gaggcgaaat 1196041 acgattcaat ttctgcataa caaaaatgtt tttgcgctat tgctgtctca atcttttcaa 1196101 tctttagcag gagtcctcgt cacaatcgtt ttaatggtcc ggatctatca aatgactgac 1196161 tccgtttttt tggcgggcct tattttatcg ttcatgtcgt ttgcgagtat agcagcaagc 1196221 ttttgcgtct ctccggtgct tcgcattctc ggttttaaaa aggtgcttgc gggagcgaat 1196281 ctgctgagag cggtctttat tatactgatg gcatacagcg tcactcatca cggacaggca 1196341 ttcttttgga ttacgctgct gtttgtgttt tgtttttcct tcgcgggcgc tttttttcag 1196401 ccggcaagat ttgcgctgct gccgattatt gttccaaaga agcaatatgt aaaagcgaat 1196461 ggtgtgatct ccctctcgaa tcaattgttc ttaacagcag gctggggcct tggaggcctt 1196521 ctgacgtacg ccgtcccttt tgaactcgtt gtcggcgctg ccatttgcct gtttgttcta 1196581 tcgggagctt ccatcagtgt gctgcatgta aatgaagaag aggctgcagg aactgctgaa 1196641 acagcatctg tcagaagtat atggaaggat ttaatgatca tccctattgt aagagacatt 1196701 actgtaatgg acatgttaga agctttggcg ggttccgtat ggtcatctgc tattctcctc 1196761 gcatttactg cggctgtttt gcatgaaaca gaggtgtggt gggggatgtt taacgcttcc 1196821 tattttatag gcgcaattgt cggcagtgtg attgctattc gtttttcttc tttttttgag 1196881 cggaatatgg gctatgccat tatgttcagc tcgcttgtaa tgtcggcgct gacccttttg 1196941 ttttcatttt ctccagtccc atttttatgc gctctggctt gtgctgcaat ggggcctttt 1197001 tatcaggtgc gtgatatttg ccaggaaacc atgctgcagg aagttattcc cgagcagaaa 1197061 cgaatcggaa tcatggctgc aaaaaatgcg attttgactc cttggtcagg cgtcacctac 1197121 tccattatgg ggctagtggc tgatgctgct ggtgcgaaaa tagcttttat cgcggctgct 1197181 gcattatata tcatgacatt tctgattgca ctggcgcagc cccgtctggt tcattacagg 1197241 cgagaaaatc gagttcaatg agaaacactt caaaatgaac ggagcagctg gctccgtttt 1197301 gctgaaaaaa aaatgaaacc atggcggaag ttcgcacgtc tttatagatg taaggctgtt 1197361 taaacaagaa gaaatggggt atatctaaaa gtatgaagac aacgaactca taaggagcaa 1197421 atcaatgaac tggtatgaaa agcttagcga gtactttcca attgaagaaa tgaaatcaaa 1197481 agcgcatatg gaagctcttc tgaaagagcg aagcgatatt tatcataaag atgaaggcaa 1197541 acatcatatt ttaatgtttg cggaattcga ttcttttatc ttcgttgatt atctgtatgt 1197601 gtctaaggat gcaagagggc aggggcttgg cggcaaattg atcgcgaagc tgaaaaagaa 1197661 aaataagccc atattgctcg aggtggaacc tgtggatgaa gatgatactg atacagaaaa 1197721 acgcctgagg ttttatcaaa gagagcattt caagcatgct cagtcaattg ggtaccggcg 1197781 ccggtcattg gctacgaatg aagtaaacaa gatggagatt ctgtactggt caccaaaaac 1197841 agaatcagaa gaagaaattc ttgaagccat gaaacagaca tatgaaaaca ttcatactta 1197901 taaagatgag aaatggtacg gagaatcgta cgaaaaaacg gatgaggtct tggaaatcat 1197961 cgatgaagaa aaacaaaaaa atattttcga tcagttaagc taattgagaa taagaacata 1198021 tcatgaacat taaaaatttg ctggattgac acattttttt cttaggatac tgttcacact 1198081 tactttttta tagtataata cctgtaaaga ttcctttttt agagtaattt caatttaaga 1198141 ataaaataga tgttcatcct actaattaga ggagtgaaga tgaatggtta cactatacac 1198201 atcaccaagc tgtacttcat gcagaaaggc gagagcgtgg ctcgaggagc acgagattcc 1198261 atttgtagaa agaaacattt tctctgaacc tttatcaatt gatgaaataa aacaaattct 1198321 tcgaatgact gaggacggaa cagatgaaat catctcaacc cgttcaaaag tattccaaaa 1198381 actgaatgtg aacgttgaat ctatgccgct gcaagatttg taccgcttga tcaacgagca 1198441 tccaggtttg cttcgccgtc cgatcatcat tgacgaaaaa cgtttgcagg tcggatataa 1198501 cgaagacgaa atcagacgtt tcctgccaag aaaagttcgc tctttccaat taagagaagc 1198561 acagcgtttg gcaaactaat agatcgtatc atcaaaagaa ggctgagtca tcagccttct 1198621 tttatttttc aacctgctgg taataaatgc tcgcaaggat gacaaacgca accgtcaaaa 1198681 tggggaggag cgtttcgact gtgccgtgct gcgccataaa aagcgacagc tttttgtctc 1198741 tgacaatcat ttctccgcca gtataagcaa gcagcccgct tcccgcgtaa atcagaagcg 1198801 gtattttctc tagtgcaata tggatgagtt tgctgcccca aataataacc ggaaccgata 1198861 cacacaatcc tataacaacg agagaaaact caccgtgtga agctcccgca actgcgatga 1198921 cgttgtccag cgacataaag agatctgcaa gcacaatcgt tcgtatcgct ctccacaggg 1198981 aggtgctgct tttaatgtgt ttcgtgtctt ttttttcaat cagcagctga tatcctaaat 1199041 acagcaggaa aattccgccg gcgcactgca agaacggaat gttcaaaaga tatactgctg 1199101 cacttgttaa tccgattctc atggcaacgg caataaatgt tccgagaata atggcttgct 1199161 gtctttgctt gtccggcaaa tgtctgctgg ccatggcaat aacaaccgcg ttatctccgc 1199221 cgaggatcag gtcaatccca acaatgacga gcagagaaat cagatagtca tgctccatga 1199281 agcggcacct cgctttcagt ccttcgcttg tactactact atatgagaca ggtcatattt 1199341 tatgatatca gccgcctgat ctgccgtttt ttaggcaaag gtgcattttt atttcttttg 1199401 tgactgtttt atcataaaat agaaatacaa aggaattcac actggccttg gttaaggtta 1199461 agatgtggac ggaatgggta aagtgtagta aagtacaatt aatcgggagc ttagatgtcc 1199521 cttcaacatc ttatatagaa gggaaggttg gcaaatggaa attgaaagaa ttaacgagca 1199581 tacagtaaaa ttttatatgt cttacggaga tattgaagat cgcggttttg acagagaaga 1199641 aatttggtat aaccgtgagc gcagtgaaga acttttctgg gaagtcatgg atgaagttca 1199701 tgaagaagag gaattcgctg tggaaggccc actttggatt caagttcagg cactggacaa 1199761 aggattagaa atcatcgtca caaaagccca gctttccaaa gacggacaaa agctcgaact 1199821 gccgattcct gaggataaaa agcaagaacc agcatctgag gatcttgacg ccttgctgga 1199881 tgatttccag aaagaagagc aagccgtcaa tcaggaagag aaggagcaaa agcttcaatt 1199941 tgtcttgcga tttggcgatt ttgaggatgt tatttctcta tctaaattga acgttaacgg 1200001 aagcaaaacg actttatatt cgtttgagaa ccgatattat ttatatgtag atttttgcaa 1200061 tatgactgat gaagaggttg aaaatcagct aagcatcctg ctggagtacg caactgaatc 1200121 ctcaatcagc atacaccgtc ttgaagagta cggcaagctg attatttcag agcatgctct 1200181 agaaacgata aaaaaacact ttgcatcata gcaaaccgat ttccttccgg aaatcggttt 1200241 tttttatgca cgaaaatgcc attttagaga tgtgaaaaat caaaaacata tagacaagca 1200301 gaaaatacag cgaacaggag ttgatcatct tttccagaaa gtatacttca tctggaaagg 1200361 agagatgaca attgtttagt gctgtgactg aagacggcca aatgtttcac cttctaggcg 1200421 ctcagcaaaa ccagaaatta aagcggagac ggttcttctg tccggtatgc gggggagagc 1200481 tagctgtgaa gctcggactt caaaaagcgc cgcattttgc ccataaacag aacaagtcct 1200541 gcgccataga catcgagccg gaaagcgcct accacttaga aggaaaaaga cagctgtatg 1200601 tatggctgaa aacgcaacgg gcttcaccaa tattggagcc gtatataagg acaatcaacc 1200661 aaagaccgga cgtcatggca agaatcaagg agcatatgct tgctgttgaa tatcaatgcg 1200721 ccactatcgc tccagatgtc tttcaaaagc ggacagaggg cttcaaacaa gaaggaatca 1200781 tcccgcagtg gattatggga tacagccgct taaaacggac tgcttcgtcc ttttatcagc 1200841 tttcaacttt tcattggcag tttatcaatg caagtccata cagagaactg atatgttatt 1200901 gtcctgaaag gcgttctttt ctccggctca gccacatcat tccattctac acaaaccatt 1200961 cttattcctc agtccaaacg atccctatcc atcgggcagg tgcaggcgat ctttttttca 1201021 ctgaaccgaa accctcaatt caatattcag gctggacgaa agcgattcac cgttttcgcc 1201081 ataaacccca tcggtttaac tcaaaggaaa caaatcgcct taggctgctg ttttatgaga 1201141 aacgacagac gcctttttct tttctgccga ctgaagtgtt tgttcctgtt agaaaagggg 1201201 cagtttttaa gagtccggtt tttgtgtggc aggggtttct ttatttgttt atgacggatc 1201261 ttggaggtaa acgtgcgcca attcgttttt cagccgtttt gcagcagtgc aaactgcaca 1201321 ttcataataa gaacattgca ctcaggtccg aatgcagcga agagtgtctt tcagaagcgg 1201381 ttaaacagta tattgatttt ttgtgcaaga agggattttt aagggagact cagaaagaag 1201441 tatatgtgct gaatcagcct gcaggaggca tacactccat gcaggatctc atagaaagag 1201501 accgcagctg ttttatagaa tgagtttgtc ttatttggct caccctaaga caaaggtggt 1201561 gggcaggctg tgaaaggcac aaaaggaaag gtttttcgtg tttttactgc ttttttggca 1201621 ttcgttctct tcattactgc atatgatttg acaaaaggca gtgaaaaacc ggaagatatt 1201681 cacaacacaa gtttattgag aaacagctgt tttttcaatt ggcttgaatc aaagaagacg 1201741 agggggatca ccatggctga ggaaaaaaaa gcaaaccaac tgcctgacag aagtgaggta 1201801 aaggcagaag acacatggag acttgaggat atttttccta gtgatgaggc ctggaataaa 1201861 gaatttcaag ctgtaaaaga attaattccg aatttatcta agtataaagg aaagctggca 1201921 gattcagctg atcatttata cgaggctctt acgtatcaag ataaagtgat ggagcggcta 1201981 ggtaggctgt acacatatgc gcatatgcgc tctgaccagg atactgggaa ctccttttac 1202041 caggggctga atgacaaggc gggaaacctg tatacacagg ccgcaagcgc gacagcttat 1202101 ttggttccgg agattttatc catagaagaa gacaaactgc agcagttcat tcttgaaaaa 1202161 gaagaattga agctgtactc tcatgcgatt gaggagatta caaaggaacg tccgcatgtg 1202221 ctgagcgaga aggaagaggc gctgcttgct gaagcctccg aggtactggg gtcatcttca 1202281 aatacattca gcgtgttaaa taacgcagat ataacgtttc catccattaa agacgaagat 1202341 gggaatgaaa aacagatcac tcacggcaac tttattaatt tcttggaaag tgaaaaccgt 1202401 gaagtccgca aaaatgcgtt tgacgcagtg tataaaacgt acggacaata taaaaacaca 1202461 atggccacga cgctaagcgg cactgtgaaa aaggacaact tctacgcgag agtgaaaaag 1202521 tacaagtccg cgcgtgaggc tgcgctttct aacaacagta ttcctgagga agtatacgat 1202581 aaccttgtta agacgattaa taagcatttg ccgctcctgc accgctatat tgcgctaaga 1202641 aagaaagtgc ttgagcttga tgaagtgcat atctatgacc tgtatacacc gcttgtgaaa 1202701 gatgctggga tgaaggtgac atacgaggaa gccaaagatt acatgctgaa aggcctcgca 1202761 cctttagggg aagaatatgc ctctatccta aaagaaggac tggaaaaccg ctgggtggac 1202821 gtttacgaaa ataaaggcaa acgcaatggg gcttattcat caggagctta cggcacgaat 1202881 ccgtatattt tgatgaactg gcataataac gtcaataatc tctttacgct cgtgcacgag 1202941 tttggacatt ccgtacacag ctactatacg agaaagcacc agccttatcc atacggcaat 1203001 tacagcatct ttgtcgcgga agttgcctct acgacaaatg aagcgctcct tggcgaatat 1203061 ttgctgaaca atttagagga tgaaaaacag cgcttatata ttctcaacca tatgcttgag 1203121 ggcttcaggg gaacggtctt cagacaaacg atgttcgctg aatttgaaca tctgattcat 1203181 acaaaggcgc aagaaggcga gccgcttaca cctgagcttc tgacaaatgt ctattacgac 1203241 ctgaataaaa agtattttgg agacggcatg gtgattgata aggaaatcgg ccttgaatgg 1203301 tcgcgtattc cgcacttcta ttacaattac tatgtgtatc agtatgcgac aggttacagc 1203361 gctgcccaag cattaagcag ccagattttg aaggaaggaa agccggcggt tgaccgttat 1203421 attgacttcc tgaaagcggg aagctcacaa tacccgattg atgtcctgaa aaaagcgggt 1203481 gttgatatga cgtctccaga gccaatcgaa gccgcgtgca aaatgtttga agaaaaactt 1203541 gatgaaatgg aagagctgct gatgaaagtc aagcagtctt aaaaaagtaa gcctgtgcgg 1203601 aaatgacgca caggcttttt taaaaccctt taaaggtttt ccggtgattc aagcggtaga 1203661 gggtaaacaa aatagacaga aacagcagag gagaggtaat ataaagcggc agcatatgca 1203721 tcatgcctaa gatattcaag cagaaaaaaa cagcaatgca cacaattgag atcaaagtag 1203781 acatcatggc ggtcctcctc gtcctttttc cttataagga tatgagtgaa tgcacttcgt 1203841 tatgttttgt gacaaaaata tgaacattaa gcatagaggt tgtcaaaagt cgacatcttt 1203901 tgttatcata aggatgtgaa attgatcaca aacaaacatt acccctttgt ttgaccgtga 1203961 aaaatttctc ccatcccctt tgttgtcgtt aagacatatg aaaccgcgct tatcccggcg 1204021 cggtttcttt agtgctaaaa atggaacgta cgtttggtta tggcataaaa aaacagcctc 1204081 aagcatatgc acgcctgcgg ctatttttca catgattgat attcatcaga ataagtgctg 1204141 agagacttcc aaaacattcc gtgtttggct tccactttgg caaccttttt agcaaacgcc 1204201 agttttttca tttctttttc tacctcttca aggctcaggt catatacaag agcaatttcc 1204261 ttcgaggcaa cgaagcggaa atattcaata aaacattcta aaggcggtgt ttccgacggc 1204321 ttcggctcgt cgccaagcat ctcaaataaa atttcttcat atacatcata tgagtagctg 1204381 ccaggaactt taagcccttc atcctcatgc tgcgtattaa aaaacgtcag tgtcggatta 1204441 acagaaacat ccatctcggc agcaattttc atgtcacatt gaagcgcctt gaccgcgctt 1204501 tgagaatgca gatctttttt gaattcttca agatcgagac ttgtattttc agcaatctcc 1204561 aaaagcacgt tttcatccgt aatatttttc tttgaaacaa ataggctctc ctgcatattt 1204621 ctgagaaatt gcatgccggc ttttcgtcct tgcagttcgg ctgctttaaa agcgagagca 1204681 gccatataag gcgatgaaag cggctgatcc tgttcgaacc agacattgcc gtcacatgac 1204741 atgccagagc ggctcgcgat cttttcccat gcttctgcga gaagatgctt ttttcgcttt 1204801 ttatttaaag cggtaaggct tgcggaagcg ataatgcgta aggtgaaaaa acgtccgtat 1204861 ctgattttca gctttttgat gacgggctct aaggaccagc attcaggaca taaagggtct 1204921 acaaacatat aaatttcaag cggttttttt ggatgaccgt ggcaatgggc gaagtatagc 1204981 tcatgctgat agtttgtcaa gatgatcgat cctccgcttc cgtttgattc accatatgcc 1205041 ttgctgtcaa ctccagccgg ccaaacaaaa actcacgaat ttcgccctcc agccctacat 1205101 ggtccattgc gtccttcata cagctgagcc acgcatcagc tctctcgttt gtaattggaa 1205161 agggaagatg ccttgctctg agcataggat ggccgtgttc ctcagtataa agaggaggcc 1205221 cgcctaaata ctgagttaag aattgcttct gtttcctggc ggtttctgtc aaatcgcttg 1205281 gaaaaatcgg cttcagcaaa ggatgagacg cgacacgctc ataaaaagta tcaacaagtt 1205341 gcgatagaag ttcctctcca atcgcttcat aaggtgcgtt aaacgattgt cccatgttga 1205401 ctactccttt aaatatggct aataggaatc ataaatccta ttgcaaaaag taattttctg 1205461 tatttcattg tttcatctag atttatttta gcaacaaggc atcatttcta caaacaaact 1205521 gccttttatg cgtttgatga ctcatttcgg ctgacagccg gggtttgtat ttcatatcat 1205581 atcacataaa aatcaggaat gcgtaagatt tcacttcgca aaaaaaccag agggaaagag 1205641 cacctctggt tacgcgtaat aaactgaagt tatttttttt acatagtttt gcgtttcttg 1205701 gaaaggagga atgcctccgt atcggtcaac attccccggt ccggcgttgt aagccgctaa 1205761 tgccatagac acattgccgt cgtatttatc cagcatttgt tttaaatatt tcgttccgcc 1205821 ctccacattt tgctgcggat caagcggatt ggaaacgcca agtgagcttg ctgttgacgg 1205881 catcagctgc atgaggccca tcgcacctgc tccgctgacc gcttttgcat taaagcctga 1205941 ttcctgtttg atgacggcgc ggatcagttt ttcatcaacg ccatatttat cagcggcttt 1206001 tttaatcgca ctgtcaatag agaagtctcc cgaacggatc tgatttgctt catgtttgtt 1206061 tgaagctgaa tctgcaacag ctgtttcagt gctttctgcc gcttttgtga ctgaacctga 1206121 attgctgctc gtatatgagt taagcccata cgctgaaagc agtgacggcg ctgttgtatt 1206181 cgcgctgttc agcatgctga gcgggcttgg cgatgaagaa ggtgctgatt gctgagatgt 1206241 cagaccgttt gtatattggc tgagcaaaga actgaaactt gaaagcgggc tttccgtatt 1206301 ctgagtgtcc gagctgctgc gtgcattaga tatggactgt aatgcctgaa gctgaagtaa 1206361 tgctgcccaa ttcgttacat tcacgatgtc attccacctt atatagactt tcgtttttct 1206421 tcataaaaac gcagaatttt atttttggtt tcgcgctgag gaatgctgaa ttgctgaagc 1206481 agcttttcga aggcttgtct gccctcatgc caatccgccg cctcaaattc aatttcatag 1206541 tcctctttat ttaaatatcg gctgtggtct aaaactatta agcctttttc tgtttctttt 1206601 tccgcacggt ttgttgctaa agatccaaag tattgtatgg catccgtatc gatctgaagc 1206661 ttgtgcagct ggtccttcac agggccctcg ggaactgaaa atccagcgag atctgatacc 1206721 tctgaaagct gctggtgcgt ttccagaagc cccacatcag ccggctcctt taatgtaagg 1206781 acatactttc cgttttttct gcggatacga agcgcagcat gtttttgttt cagcgcgaag 1206841 ctgtctgtat caaaataatg attcttttga tctgtaaaat ctttttctgt cagctggagt 1206901 gccgatgcta tgtttttgaa ttcttgtttg gtcagcatgt ttttaaattc gatttcaatc 1206961 tcttggctca tgatgctctt cctttccgcc ctgtaaatct tatttttact attatctctt 1207021 tagatgttag gtttatcaat atcgagctcg atatgataaa atgaatctgt actttgttta 1207081 aaaaaggaga gcattatgca aaacagaatc gaaattttga atgcaacatt atcggatgat 1207141 cagcttcgcc ttgcctgtca gacagaagga aacgaagcgg aacgcaagcc gtcaggtcaa 1207201 atgcttgttg attctgacca ctttgctttt gtatacatac ttgaattagc tgattctttt 1207261 gaatatgtca ttataaagga acatgtatgg ccggaactga agcaggccca tgcacaaaaa 1207321 ataccggttg ttttagaggc aggagaccaa acaattgaac tggcaggcct gcatgaggag 1207381 ctggaatatc ttttagaaaa tataaaagat aatgcaaact atggagaaga aatggaagaa 1207441 aaagtgaaac gcgtgttttt atagaaactg gttcggaatt gggggatgta tgatggatga 1207501 caaacaatgg gagcgttttt tagtgccgta ccgccaggct gtcgaagagt tgaaagtgaa 1207561 gctcaagggg atccgcacac tatatgaata cgaggacgac cattcaccga tcgaatttgt 1207621 gaccggacgc gtcaagcctg tggcgagcat acttgaaaaa gcgagacgga aaagcatacc 1207681 gctgcatgaa attgaaacca tgcaggacat tgctggcctt agaatcatgt gccaatttgt 1207741 cgatgacatc caaatcgtaa aagagatgct ttttgccaga aaagatttca ccgttgtgga 1207801 tcagagggat tatattgcgg aacataaaga gagcggatac cgatcatacc atcttgttgt 1207861 gctgtaccct ttgcagacgg tatccggaga aaagcatgtt ctcgtagaaa tacagatccg 1207921 tacactggcg atgaattttt gggcgaccat tgaacattca ttgaattata aatacagcgg 1207981 aaacattcct gaaaaagtaa aactaaggct tcagcgcgct tctgaagcgg cttcccggct 1208041 tgatgaagag atgtcggaga tcaggggtga agtacaggaa gctcaagctg ccttttcaag 1208101 aaagaaaaaa ggaagcgagc aacaataggt aaaggggaag aagagcatga aatttgccgt 1208161 atcatcaaaa ggagatcaag tttctgatac gctgaaaagc aaaatacagg cgtatttatt 1208221 ggattttgat atggaactgg atgaaaatga accggaaatc gttatttcag tcggaggcga 1208281 cggaacgctt ttgtatgctt ttcacagata cagcgaccgt ttggacaaaa cagcatttgt 1208341 cggcgttcac acaggtcatc tgggttttta tgccgactgg gttcctcatg aaattgaaaa 1208401 acttgttctt gccatcgcga aaacgccgta tcatacagtc gaatatccgc ttctcgaagt 1208461 cattgtgacc tatcacgaaa acgagcggga agaaagatac ttagctttga atgaatgtac 1208521 gattaaaagc atcgaaggaa gccttgttgc tgatgtggaa atcaaagggc agctctttga 1208581 aaccttccgg ggcgacggcc tctgcctgtc aactccatca ggcagcacag cctacaataa 1208641 ggcgctgggc ggagcgatta tccatccgtc tatcagggcg atccagcttg cggaaatggc 1208701 ttcaattaat aaccgcgtgt tccgtacggt cgggtcacct ctgcttctcc catcccatca 1208761 tgattgcatg attaagccga gaaacgaagt tgactttcaa gtgacgattg accatttaac 1208821 ccttctccat aaggatgtaa agtcgatccg ctgccaagtt gcatccgaaa aagtgcggtt 1208881 tgcgagattc cgtccgtttc cattttggaa aagagtccag gattcgttta ttggaaaagg 1208941 tgaatagaaa gaggacatat cgtggagcat ttttttatca gaaagaacat tacttccgct 1209001 gaggacggga tgactgtaaa agaatatgcc ggtgaactgg gaatttcgaa acgtctgctg 1209061 accgatatta agtttggcgg gggagacctg cagattaacg gtgagcatgt gacggtcaaa 1209121 tacgttttga aagagggaga tcttcttatc gtgaagtttc ctgaggagca ggtgagcgag 1209181 acgctgttgg cagagcctgt tccgctcgat atcctttatg aggatgaaca tgtgcttgtg 1209241 ataaacaagc agccgtatgt gtcatcaatc ccttcgagag agcacccctc cggcagcatt 1209301 gccaatggaa ttattgatca ttatcaaaca accggagtga gggcgacagt tcatcttgtc 1209361 acccggttag accgggatac atcaggtatc atgcttgttg ccaagcatcg atttgcccac 1209421 tccattttat cgtctgcgca aaaaaacggc cttgtgaaac gccggtatgc ggcagtggtt 1209481 cacgggcgga tggcacagat ggagggaaca gtcgatgctc cgattggcag acatcctgac 1209541 agtattattg aacggacggt aacgccagac ggccagaagg ctgttactca tttttacgtc 1209601 acatgtgcaa atgatgacat gacctcggtg gcattgcagc ttgagactgg acgaacccat 1209661 caaattcgtg ttcatatgag ctatctcggg cacccgttgt gcggcgatac actgtacggc 1209721 ggaacgagac aggaaattgg ccggcaggct ctgcacagcg agcatctttc gtttatccat 1209781 ccgctgacac aggagaacat gaggtttcat gctccactgc ctcaggacat gagcaaactg 1209841 ataaaaggag agaatcattg attctctcct tttttatatg gggcgaaatc ttgattcgtc 1209901 gtaaggcagg gagcttggaa cagagacggt ttctatttct ggaaagcgaa agcctgtcag 1209961 ttgatttccg aacacgcagc ctgtatcaat gttgatggtg cgattgacct tccgaggctc 1210021 tttcacaggt gtatgaccgt ataccaccca agcctttccg ttataggctg ccgcccaatc 1210081 acgcctgatg ggtctgccgt ccggatatgt ttcacccgtc acgtcaccgt aaagcacaaa 1210141 gtccttcact ctgcgggtat atttgccgat atcgtcagct cttatgccag catgggcgac 1210201 aactaattct ccattatgta agatgtcgta aagcggcgct gtttcgtaca gcttcataaa 1210261 ctgttcgctg actgattttt tctcatcttt ggaaagttcc tcaagctctg ccgctgttgt 1210321 ttcgagacca tgcatcactt ttaccggatt tccttttaag taacgatata atttattgca 1210381 atggtttccc gggacataac gcacagcgcc tttttcgtaa gcgccggcta caaatcggat 1210441 gacctctatc gatttgggcc ctctgtcagt taaatctccg gcaaaaacaa gcaccctgcc 1210501 ttcttcatgg acaggtactc catttttgat tgtatagcca agcttttgga ttaatgcagt 1210561 catttcgtca tagcagccat gaatatcgct gatgatatcg taagccatgc ggtctcctcc 1210621 ttaccgattg ttttatttat tatgaagcaa agtgttgtga gtcatcacaa gcttttatgt 1210681 gcaaattata gaagaagaat cattttctaa acaggattaa gaccttatca ctttattttt 1210741 catcatcacc cttgttaaaa tcgcgttatg ttttttaaaa atgaggtttt gttctctgag 1210801 tgagaactag cataaccctg acttaaaaag gaggttctga ttatggcgca tacatctgtc 1210861 gcatctttag ttgttgtact tatcgttgca tttttgacac ccatcctttt gcatcggttt 1210921 aaactcagca tcccggttgt tgttgctgaa atcattatgg ggctgataat tgggaaaagc 1210981 ggccttaatt tagttgtgga gggtgacacc tggctccaga cactctctat gctcggattt 1211041 atctttttaa tgtttttaag cgggcttgaa attgattttt cgtcgtttga gaaaggaaag 1211101 aaaaagcagt tcctgccgaa tggcaaggaa gcgccgaata cgtttgctgc ggcatctgtt 1211161 attttcgtcg gtatttttat tttatcattg ctcttgtcct atgggttcgt cttggccgga 1211221 tttatccaaa atgcattttt gatgaccctg attatttcaa cgatttcatt aggcgttgtc 1211281 gttccaacat taaaagaaga acggatcatg aattcgaata tcgggcagat tattttgctt 1211341 gttgctgtta ttgctgattt ggccacgatg attcttcttg ctgttttttc ttctttatac 1211401 ggagaggaca gcggaaacat gtggctcctg atgattctgt ttgcggccgg agtggtgctt 1211461 tactttttcg gccgggtctt caaacatcgc tcttttgttc aatccatgtc aaaagggacg 1211521 atccagatcg ggacgcgtgc catttttacg ttaatcattg tactcgttgc cctgtctgaa 1211581 tcacttgggg cggaaaatat tctcggcgct ttcttagcgg gggttcttgt ttccctgctt 1211641 tcgccaaaca aagaacttgt tcagcagctg gactcattcg gttatgggtt cttaataccg 1211701 attttcttcg tgatggtcgg tgtgaagctt gatatttgga ctcttttcca ggataaaaca 1211761 attttaatca tgattccgct cctgctgctt gcgctgttag tcagcaaaat cattcctgtc 1211821 atgtacttaa agaagtggta tgataaccga accattttcg cgtctggttt cctgctgaca 1211881 tcaacgcttt cgctcgtgat tgctgctgca acaatcggcc agcagcttca cgtgatcagt 1211941 acaaatatgt caggagcgct aattttagta gccgtcattg caagtatttt tacgccgatc 1212001 tgttttaaaa aattatacaa acgggaagag cagccggagg agaaaaagac gattacgttc 1212061 attggcgcca atcaaatgac tttgcctgtc acactcgaat tgccagagga agagtatgac 1212121 gtgcgtgttg tacacgtcta ccaagagaat gcggaggaaa agctgtcaga atcagtgttt 1212181 gctgttgaaa caatttctga ctatgaacac gagacgcttg aatcactcgg catttttgaa 1212241 acggatatcc tcgttgtggc gacaggaaat gaagatatga atgcagacat tgcattactt 1212301 gcaaaagata aaggcacaga aagagtcatt gcaagcgtag gatcaccgga gcatgaagca 1212361 gctctgaagg agcagggaat cagcatcttt tctattctgc tgtcgacaaa aacgctgctt 1212421 cgcgcactga ttgaagcgcc tggcgtcatg aagctgctca cgaaccaaga gtcttcgctg 1212481 tatcaaatta atatggagaa cagtaaatat gatggtgtca ttttacggga attcccttta 1212541 acaggtgacg tcatctttgt caggatcttc agaggtgtgg acagcatcgt tcctcatggg 1212601 gatacgaggc tgaaacttgg agaccgttta attgtcaccg gatctcgggg gtacgtaacg 1212661 gatcttaaga aaacattgga aggataaatc ttgaccaaat aaggattcgt gttaatatag 1212721 aggtgcagaa caattcaata tgtattcgtt taaccactag gggtgtcctt cataagggct 1212781 gagataaaag tgtgactttt agaccctcat aacttgaaca ggttcagacc tgcgtaggga 1212841 agtggagcgg tatttgtgtt attttactat gccaattcca aaccactttt ccttgcggga 1212901 aagtggtttt tttattttca gagggggaat gatttgtgaa gttttcagaa gaatgccgca 1212961 gtgcagccgc agaatggtgg gaggggagct ttgtccatcc gttcgttcaa ggaatcggtg 1213021 acggaacgct tccgattgac cgttttaaat actacgtact tcaggattcc tattatttaa 1213081 cgcattttgc aaaggtgcag tcatttggtg ccgcttatgc gaaggatctt tatacaacgg 1213141 ggcggatggc aagccatgcc caaggtacat atgaggcgga aatggcgctt catcgcgagt 1213201 ttgccgagct gttggaaatc agcgaggaag agcgtaaggc gtttaagccg tctcctacgg 1213261 cgtactctta tacatcccat atgtaccgtt cggttttgag cgggaatttc gcagaaatct 1213321 tagcggccct gctgccatgc tattggctct attacgaggt tggtgagaaa ttgctgcatt 1213381 gtgatccggg gcatccaatt tatcagaagt ggattggcac atatggcggt gattggttta 1213441 gacaacaggt cgaggagcaa atcaaccgct ttgatgagct ggcggaaaac agcacggagg 1213501 aagtgcgtgc caagatgaaa gagaattttg tcatctccag ctactatgaa tatcaatttt 1213561 ggggaatggc ctatcgaaaa gaaggctggt ctgacagcgc cataaaagag gtggaggaat 1213621 gtggagcttc acgccataac ggatgacagc aagccggtag aagagctagc gagaatcatc 1213681 attacgattc agaatgaagt tgattttatt cacattcggg aacgctcaaa atcggcggcg 1213741 gatattttga aactgctcga tcttattttt gaaggcggta tagataaacg aaaattggtg 1213801 atgaacgggc gcgtggatat tgcacttttc tctactattc accgcgtgca gctgccaagc 1213861 ggcagctttt caccgaagca gatcagagcc agatttccac accttcatat cgggaggtcg 1213921 gtgcattcac tggaggaagc ggttcaagca gaaaaggaag acgcggacta cgtgctgttc 1213981 ggccatgtgt ttgaaacgga ttgcaaaaag ggtcttgaag gcagaggagt atctttgctg 1214041 tcagatatca aacagcggat ttccatcccg gttatagcca tcggggggat gacgccggac 1214101 aggttaagag acgtaaaaca agcaggggca gacggcattg ctgttatgtc aggaattttc 1214161 tcttccgctg aacctttgga agcagccaga cgatattccc gcaagctaaa ggagatgcgc 1214221 tatgaaaagg cattatgaag cagtggtgat tggaggcgga attatcggtt ccgcaattgc 1214281 ttattatttg gcaaaggaaa acaaaaacac cgcattgttt gaaagcggaa caatgggcgg 1214341 cagaacgaca agtgccgctg ccggaatgct gggcgcccat gccgaatgcg aggaacgtga 1214401 cgcgtttttt gatttcgcta tgcacagtca gcgtctgtac aaaggtcttg gagaagagct 1214461 ttatgcatta tccggtgtgg atatcaggca gcataacggc ggtatgttta agcttgcatt 1214521 ttctgaagaa gatgtgctgc agctgagaca gatggacgat ttggactctg tcagctggta 1214581 ttcaaaagaa gaggtgttag aaaaagagcc gtatgcgtct ggtgacatct ttggtgcatc 1214641 ttttattcag gatgatgtgc atgtggagcc ttattttgtt tgcaaggcat atgtgaaagc 1214701 agcaaaaatg cttggggcgg agatttttga gcatacgccc gtcctgcatg tcgaacgtga 1214761 cggtgaagcc ctgttcatca agacccctag cggagacgta tgggctaatc atgttgtcgt 1214821 tgccagcggg gtgtggagcg gaatgttttt taaacagctt ggactgaaca atgcttttct 1214881 ccctgtaaaa ggggagtgcc tgtccgtttg gaatgatgat atcccgctga caaaaacgct 1214941 ttaccatgat cactgctata tcgtaccgag aaaaagcgga agactggttg tcggcgcgac 1215001 aatgaagccg ggggactgga gtgaaacacc ggatcttggc ggattggaat ctgttatgaa 1215061 aaaagcaaaa acgatgctgc cggctataca gaatatgaag gtggatcgtt tttgggcggg 1215121 actccgtccg ggaacaaagg atggaaaacc gtacatcggc agacatcctg aggacagccg 1215181 tattttattt gcggctggcc atttcagaaa cgggatcctg cttgctcccg caacgggcgc 1215241 tttgatcagt gatctcatca tgaataaaga ggtcaaccaa gactggctgc acgcattccg 1215301 aattgatcgc aaggaggcgg ttcagatatg atgctacagc tgaacggtaa agacgtgaag 1215361 tggaaaaaag acacaggtac aattcaagac ctgctggcgt cgtatcagct tgaaaataaa 1215421 atcgttatcg tggaaagaaa taaagaaata atcgggaaag aacgctatca cgaggttgag 1215481 ctttgtgatc gtgatgtcat tgaaattgtc cattttgtag gaggcggatg agcatgttaa 1215541 caattggcgg aaaatcattt caatcaagat tgctgctggg cacggggaaa tacccatcgt 1215601 ttgacattca aaaggaagca gtagctgttt ctgagtctga tattttaaca tttgctgtaa 1215661 ggagaatgaa catttttgaa gcatctcagc cgaattttct ggaacagctt gatttatcca 1215721 aatatacgct tttgccgaat acagcgggcg ccagtactgc tgaagaagcg gttcggattg 1215781 caaggctggc gaaagcttca ggcctttgtg acatgattaa agttgaagtc atcggatgca 1215841 gccgttcctt gctgcctgac cctgttgaga cattaaaagc gtctgaacag cttcttgaag 1215901 aaggctttat tgtgctcccg tacacgtcgg atgacgttgt gctggcgaga aagctggaag 1215961 agctcggcgt tcatgccatc atgccgggtg catctccgat tggatcagga caaggaatct 1216021 taaatccttt gaatctgtcg tttattattg aacaggcgaa agtaccggtc atcgtggatg 1216081 cgggaatcgg ctcgcctaaa gatgcggcat acgcaatgga gcttggagcg gatggcgtac 1216141 tgctcaatac ggctgtatct ggcgctgacg atcccgtgaa aatggctcgt gccatgaagc 1216201 tcgcagtgga agcagggcgc ctttcttatg aggcgggccg aatcccgctt aagcaatacg 1216261 gaacggcaag cagtccggga gaaggtcttc ctgtatgaca ggcaggtatt caaggcagga 1216321 gctgtttgct ccgatcggcc catccggcca gaaaaaattg aaagaagcgc gcgccgtgat 1216381 tatcggcgcc ggcgcgctcg gaacagccag tgcagaaatg ctggtgagag cgggagtcgg 1216441 ctctgtgaaa attgccgaca gagattatgt tgaatggagc aacctccagc gccagcagct 1216501 ttatacagaa gatgatgtca aaaaagaaat gccgaaagca gccgctgcgg agcgccgtct 1216561 ccgttcgatt aacagcgatg ttgatgtgac cggccttgtc atggatgtga cagcagaaaa 1216621 tatcttcgag ctgattaggg atgcatcgat tattgtggat gcggctgata attttgaaac 1216681 ccgcctgatc gtaaatgatg ctgcggtaaa ggaagggatt ccttttcttt acggtgcctg 1216741 tgtagggagc tacggtctta cctttaccgt ggtgccgggt tctactcctt gcctgcattg 1216801 cttgctcgat gcacttccga ttggcggagc aacatgtgac acagctggca tcatcagtcc 1216861 ggctgttttg caggtagcag tctttcaggt aacagatgca ctgaaactgc tgacgggaga 1216921 ggagtgcgag ccggtgctgc gctcctttga tttgtggaaa aacgagcggt cagaagtgag 1216981 agcggccagt ctcaaacatg acgcatgccc aagctgcggc acaaaggatt ttccgttttt 1217041 gtcttatgaa aatcaaacaa aagcggctgt attgtgcggc aggaacacgg tgcagatcag 1217101 atcatctatt acgaaagaag cggatcttga agcgcttgcc ggtcagctga ggcaggccgg 1217161 gcttgaagta gctgcgaacc cgtatttaat ttcctgccgc tcggatgata tgaaaatggt 1217221 gctgttccgg gacggcagag ctttgatcca tggaacaaat gatattgccc gggcaaaatc 1217281 catttatcat aaatggattg ggtaataaaa ggagtgtagt gtaatgagta tatataaagc 1217341 attgacaatc gccggatcag attcaggcgg cggcgcaggg atacaggctg atattaaaac 1217401 ctttcaagag cttgatgtat tcggaatgtc tgcgattacg gcggtaaccg ctcaaaatac 1217461 gcttggcgtt cacggggtgc atccgctgac tgtagagacg ttgagacagc aaattgacgc 1217521 tgttgctgag gatttgagac cggatgcagt taagacggga atgctctgga atgccgacat 1217581 gattgaagaa gtggcaagaa aaattgacga gtacggattc aatcgtgtaa ttgttgatcc 1217641 ggttatgatc gcaaagggcg gggcatcctt gctgcgtgat gagtcagttg ccaccttaaa 1217701 ggagttgctc attccaagaa gctacgcgat tacgccgaat gtcccggaag cagaaacgct 1217761 gacaggaatg acaatcagct cgctggatga ccggaaaaaa gcagcggagc agctcgtcaa 1217821 gatgggtgcg cagcatgtca ttatcaaagg cgggcaccag cctgaggaca atcacattac 1217881 tgaccttctt tttgatggca gcatgtttat gcaaatcacc catccttata tcaatacgaa 1217941 gcatacgcat ggcacaggct gcacctttgc tgcggcttta acggcccaaa cggctaaagg 1218001 agacagcatc catcaggcat ttgaggttgc ggccaacttt gtccgtgaag cggtggaaaa 1218061 tacgctcggc atcggatcgg gacacgggcc gacaaaccat ttcgctttta aacgaaacag 1218121 cttaaataca agccgatgag atcaccagct gatggtgatc tcttttgcgt ttgctacggt 1218181 atgcgctttt catctggaca aggttatgat atgataggaa ttaagatcag gtactaatac 1218241 tatgtcttta ttaaatatag gaggctttat acatatgaat ttttcacttg aaggccgtaa 1218301 cattgttgtg atgggggtag ccaacaaacg cagcatcgcc tggggcattg cgcgttcttt 1218361 acatgaagcg ggtgcacgtt tgattttcac atacgctggt gaacgcctgg agaaatccgt 1218421 tcacgagctt gccggaacat tagaccgcaa cgattccatc atcctccctt gcgatgttac 1218481 aaacgacgca gaaatcgaaa cttgcttcgc aagcattaag gagcaggtcg gtgtaatcca 1218541 cggtatcgcg cattgtatcg cgtttgccaa caaagaagag cttgtcggcg agtacttaaa 1218601 cacaaatcgt gacggcttcc ttttggctca taacatcagc tcatattctc tgactgctgt 1218661 tgtcaaagcg gcacgtccga tgatgactga aggcggaagc attgtcactt tgacgtacct 1218721 tggcggagag cttgtgatgc caaactacaa cgtcatgggt gtagcaaaag cttctcttga 1218781 tgcaagtgtg aaatatttag ctgctgactt aggaaaagaa aatatccgcg tcaacagcat 1218841 ttctgccggc ccgatcagaa cattatctgc taaaggcatc agcgatttca actctatctt 1218901 aaaagacatc gaagagcgtg caccgcttcg ccgcacgaca acacctgaag aagtgggcga 1218961 tacagctgcg ttcttgttca gcgatatgtc ccgcgggatt acaggtgaaa atcttcacgt 1219021 tgattctggt ttccatatca ctgcccgcta agcaggatct atatcaagca atcccgaata 1219081 gggattgctt ttttatttct tctgattttc agctttctgt catatagata gaatatgaca 1219141 caatcggagg gatgaagatg tctaataaga aaagaaacgc ggataaaaaa ccgctcatgt 1219201 atattgttca gccggattat gcagaaacta caaggtcatc catgcaggag attgtcatca 1219261 aaagaaaggc cgacaaaccc gctccgccaa aagctgagga aaagccggct taccatgaga 1219321 agcagcagga ggaagccgtg gcacaggatg tcctgcaaga agaccaaaag cctgcagccg 1219381 aaccagtgag tcagcaaaca caagaggcga gagagccaga gaacataaaa agccaagagg 1219441 aacagaaggc agagccgcag gccgtagaag aaaccgttga acacgagccc ccgaaagcag 1219501 aaaaaaagga agagcctgca cttgaggccc ggaagcctga gaaagaaccg gaagctgtcc 1219561 atagtgctga taaagcggag gaaaaagcac cgccggcacg aaaagtgaaa aaaccgatga 1219621 gcaagatgac gatccacgaa aaaattgatt ttttaacaaa gctgcctcat aacatgccga 1219681 gagcgctttg tttgattgaa gccaatggaa gaacgtacag gggcgtgatt gtcggaagaa 1219741 gaaatgattc cgtcctgctt cgaacaaccg gaaacggagc cccaaccgaa ctggcaatcg 1219801 atgatattac ctctttgcac ccgctcggtt tttaacgaaa aagaaaaaag ctgcccggct 1219861 gatgttgccg gacagctttt tttacataga gaaaagcctg caggcctgca agcttttcca 1219921 gcttatgatt aatgatgatg tgtacgattg attaatcgag gatttaagca gttgattgcg 1219981 cagaagcagt ctaagtcaac ttcaatacag tagttcgttt tttcgagtcg gaacacttca 1220041 cacaccgtat ctttatcggt gaagtccaaa atgtgtttgt gttcgtcaaa tgcgattaat 1220101 aatgacagtg ttgcacagct tccatgcact ctttcgaccc tgaaaaatac tgtattaaag 1220161 caagggccgt tatcgagttc gccgacattt ccgaaggcga ctaatggcgt tgattttgat 1220221 gtaaatattg caaaaggcac tgtgtcgcct aacgaatggc ttacagataa aagcttagag 1220281 tggcagccgg tcgggcagtc ttcttcaaca gcgttttgca gatcttcaat attttctaca 1220341 gcttcacgca cgcagcttga tgttttctgg ctcatattat ccctcctgcc ttataaattt 1220401 gagactggcg aaatgatgga gagtcagctg cctcacgctg gaagcagctg aatgatttgc 1220461 acctgtaata gagtttggaa ggggattcct ctttacaagt gtttatccat tgtgatgatg 1220521 ctttttatct ttgtgaggcg atgttctgtc aactagctct ggtgacaggc actgaatcgc 1220581 gcagaagcat ccgagatcca cttcaatgca gaaatctgtt ttttctagcc cgaagaaatc 1220641 cgggtcgcaa gggtggcaaa cacttaaggt atcgcctttg acatcgaccg ggcgtaaaat 1220701 agacagtgtt gcacagcaat cgcataattt ttcgacgcgg aagaaaatgg attcaaagca 1220761 ttgcatatca tccacaaatc cccctacgtt tccgaatgtg gagaacaatc cgcctttttt 1220821 atcaaaaacg agaaacggaa ttgtgtcttt tccagcaatc gtagggttta aaaggttggt 1220881 atagcagcca gtcggacact gttcttcaac tgcctcctgc tctgctaaaa tcttttccac 1220941 tgcatcgcat acacagttct catgccggcc atgggttttt ccgcagctca ttgatttcag 1221001 ctccttcttt atagggtatt tgactttagt ccttaacaac atatgtaccc gtgccccact 1221061 tggtgtgggt gaacgtctat atattcatca tatgcttgga aaataagaaa aagcagagcg 1221121 tttttagctc tgcttttagg tcctagagga caagagtgat aactaggatg gctacgagtg 1221181 tatttgttgc tgtagaaata agggttgcga tatcggcatc tactgttgtg acgtttacgc 1221241 cgcgggaaca ttcgatgaga agtttttggc ggtttacttg tttgttagct gtaagctgta 1221301 acaaatcttg tgcgactaat tcggcaatta cgccgtctgc aattgatgtc agagttgccg 1221361 ttacgacagc ggcattaagt gctgttacaa ctgatgttac ggcttgaacg tctgtagatg 1221421 taacattgat gtcacaagaa tctctaataa taatcgtttc atctgaaact tgtttgttga 1221481 gatttgcttg agctagatct tggtcgatga aggcgttgtc gttgccaaaa aaaccattgc 1221541 cattacagca aacgtcgcaa tgacattttc tttcgtgttt ttctttatct ttctctttgt 1221601 catctaacgg atggtcacag tcaggatcaa gtgcaaccca agaatatggt ctgctttcca 1221661 tatctattcc tccttttctt ttactgttat taaatgagcg agcctcttat tttgactgag 1221721 tcatatatcc tgatgaagaa ccctattttt tatgattggc taattgttat cgtttttccg 1221781 tctttgtctg atctgttcaa tgagctgctc tctgcggctt aacggttttg tgttcttttg 1221841 ctcttgtgcg gctgcttctt cttttttctt cttttggttt tctattagcg cttgtgattt 1221901 agcttgtaag tcttttacaa gatttaagag catttctttt tcttcgtctg atactttttt 1221961 cattttgtct tttgtgaccc catgtttaga aaatatattt tggaccagca ttttcgtcat 1222021 tggatcaact tctggaagct ttgcaagctc ttctttgaat ttatcgttat ctgacatttg 1222081 ttttcacctc gtcttttaag tttgtgaaaa gaaagggtta aaggacgtca agttcactaa 1222141 gaatgctgtt taacacctga agcaagattt gtacaaaggt tattatctcg tcggcagaca 1222201 aagtaatttt gatgttgcgg ctgttgataa ttttaatgat ggttcttttt ttgatttggg 1222261 agctatcgag aataagaatt tcacttgcca ctgcgtcagc caaatcctcg tcggcgatga 1222321 cgagctgagt cgccacgata atcatggttg tcacaaaggc ttgtatagaa agggcagctg 1222381 ttatatgtga cgtgtcaatt gtgatatttt cgcaatcaat cacttcgatc tgctgttcga 1222441 attcgcttga taattgctca aatattgcag ggtgcaggga ttcgactttt tcttcaaatg 1222501 acataacctt cactcctttc ttatccatac tctatataat gcaaatgggg tgcagagcgg 1222561 aataataaaa ataaccaatt ttctgccgga caagatacaa ttcatgaaga atagggtttt 1222621 ggcatatatg tgaagggatc atgattggca aaggagtgaa cgagtggtta taaatgggct 1222681 gacaattgtt cttctatcgc ttgcggtctt tcggctcgcc cgcctgctgg tgtttgacac 1222741 gattatggcg ccgcttcgca gtctgtttca tgaagagaag gaagaaaagg atgcggacgg 1222801 gaacattgaa acctatatcg tgattaaggg aaccggtgtc agggcgttta ttggtgaatt 1222861 gctgagctgc tattggtgca caggcgtgtg gtgtgccggc tttttgattt tatgccaggc 1222921 ggtgatcccg caagcggcgc agtggctgat tttacttttg gcgatcgccg gccttgccgg 1222981 cattatagaa acgctcgtat caaaatggct gcaagaataa ggcgttacca ccagcaactt 1223041 tctgtcagaa tacgcataaa gtagcatata tgacataagg aaaggaaggg gacaaaaatg 1223101 aatcagcatc ataaaccttc ccaaaaatct ccatatacag attcatcgta tcaatcaaaa 1223161 aagataaaaa agaaaggctg cgggtgcgga aataaaaaga aaaagcctca atagcctggc 1223221 aaagaaaccg gagaactccg gttttttgtt tttttaacga ggcggtctcg ctcagcatat 1223281 atcataagcg gggggataaa agtgaatgag tttgaaaaat ggatagaagg aagatatgaa 1223341 ccacatgaac aaaagcaaaa agagcatgaa gacacgatgg gcagtatcag aaaagacttg 1223401 gatgcatttg ataaagccgg tctggaattt gaagatgaga ttgaagagct ggctgaaaaa 1223461 acggaggcct tacttaaaaa acatcaagct caatatgatc aatcgtaaat ccgcaaacgc 1223521 cctatgcgaa tatccaagcc gatcccagca gctcacatag tgtatagaga gtaaaggagg 1223581 tgcttatcta tgggctttgg atacggattc ggcggcggct acggcggcgg ctgttatggc 1223641 ggttatgctg gcggttacgg cggcggctat ggttcaacat ttgttttgtt ggtcgtatta 1223701 ttcattctcc tcatcatcgt aggtgcatct ttcttttaag atgtattgag gaagtacggg 1223761 ttataacccg tacttccttg ccttgtgttt atttttaaaa atgttggaaa agcacattgt 1223821 attatgtgca ttcatacaat accgtattac tccgccaaaa ggaggcgcat tatggataat 1223881 caatttttta agaacatcga aaagaaaaca ggtgtgaaga tgcaggatgt aatgaatctt 1223941 gccggatcac tccaaaacgc taattttaaa gatgaaaata cagtgcgcag tgtgattaac 1224001 cgcgtagcgc agatggcaaa cagacgcgtg ccaaaagaat tagaagataa aattgtggaa 1224061 tctattacaa gcggaaaaga aaagcttgat tttggcacga tttctaaaat gatggataat 1224121 aaataagtgg atggcctggc tgactcactg cagcgggcct ttttttacag taaaaacccg 1224181 gcagtaatct gccgggctgt taatgatgca agggctgtct tgctttctgt agcaggggat 1224241 acaaaaatct tgagcggttg gctgttttgc cgcgcctgtt agcagggcaa gacaaatata 1224301 aatgctgttt cgcccgggtc atggctacat ataaaaggcg tctttcctcc tcaagagcgg 1224361 cctcgtctcc ttttcttgcc gtttctaatg agaaatcgtg cggaatcgag ccatctacag 1224421 tgcctaacac gtagactgtt ttgaattcaa ggccttttga ccggtgaatg gtcatcagct 1224481 gaacgccatg ttcatccgtt ctgtttttct cagcggccct catatggtct acgtgggcaa 1224541 gaaagtcagg aatcgttttg aacttcttgg cgacaacctt gatgtcgcgc aggtcatcag 1224601 agcctttttc cagcttgttg ccctcattgc cccgcttttt taaatactcg gagaagccca 1224661 tttttccttc tgcaaaggtg atggcttcta cgggtttcat tgtgcggagg cttgcaaaaa 1224721 acggtacgat tttcttgatt ttgtccagct ggaatggctt cagatcaggc aatttggcca 1224781 gcgctttgat catggtacag tcctctgtaa tcgagagcgc cttcagcgta ttcaaagcgg 1224841 actgttttaa aaacaaggcg ggaagcaagt gtttaatcgc ctcggtgtca tcctcatttt 1224901 ggctggcgta caagtaggcg agaatctggc ggacgatccg tctgctgtaa aacgattgga 1224961 cgccgcggtc agctgtatac ggaattgacg attgatgaag cctttcatat atagcacggc 1225021 ctccgctgtt tgtgcggtaa agaaccgcaa agtcttctgg actggctcca ttttgaattt 1225081 tttctttgat atcggaaacg accattgtgg cttcttcctc ttcatcataa ggataaaaca 1225141 gcacagggac ctgaatgtca tcgcgggccg cttcaagcgt tttggcatat ctgtttttgt 1225201 tctttttcac aacgatatca gcactagaga cgatcgggtg cgtagacctg tagttcgcag 1225261 ttaaatagat cgtcttcgct cccggataat ccttttgaaa atcaagaatg aaagacggat 1225321 tgcttccgcg aaacgcgtag atggactggt catcgtctcc gacacagcac aggttttgct 1225381 ccgggctggc gagcatttgc atgattttgt attgaaccgg attaatgtcc tgaaactcat 1225441 caattaagat atacgtaaac cgagattgat attgttccag aaggtcaggc cgctcgataa 1225501 acaattcata gcaggctgaa gccatgtcat caaaatcaaa ttggctgtgt tcttttttct 1225561 ggcgttcata atgttcatat aaacgataaa cttgtttttc ccactcatct tttagaggga 1225621 tgcgttcatt tgggacataa gtgtttttcc aaaaaccgat ctgctgcagg gcttggtcaa 1225681 ctggggattc tttctcatcg atgccttctt catagagtgc ttttttgata tattgttccc 1225741 gctgccactc cattttcagc agatgctcac cgttccattt agcagaatta gagtgataca 1225801 agatcttata aaacagactg tggaatgttc ctgtcacaat tcttctgact tttgccggct 1225861 gtaatccgta ctggttcgcc atacgctctt tcatttcagc gacagctttt gttgtaaagg 1225921 tgacaagcag catattttca ggcggtatgc ctaagtgttc gatcatgtgg gcggcacggg 1225981 ctgtcagtac ccgtgttttt ccgctccccg cacctgcaag cacgaggagc gggccctctg 1226041 tttccgtgac agctttcagc tgatccgtgt ttaaaccgac agacggaaaa aggctcgtat 1226101 cgggttctat tgtttttggc acaaatggtg ttcctggttt aatgcttcta ggacggtgcc 1226161 attctgtaac agctggggac gggtcagcgg cgatcgcttt tcccttgggt aaacgaatga 1226221 caccagattc ctgatcatct tcttttttcc cctctttaga gggcttcggt tcgcacgcct 1226281 cctcacatgc cggaaaatcg cctggctggc gatggataaa ctctggcgga tcggcgatgt 1226341 taagccgtaa caaaacgggc tttccgcaat gagaacaaaa taaatgtcct tttattccct 1226401 cttcaaagag gaattgataa tgttctctcg aatatgtatg taaatgtatg attctatcat 1226461 tcagtcgggc gcatttcaaa aaggggtcct cccaatcaaa aggtgttcat tacagacaat 1226521 gactatcata tcaaaagaaa tgtgtttcaa aaagtaagtt taagggaaaa gagacagcag 1226581 aggggtgggt attgtatgat atatgcaggt caaattcaga accagcaata cgctcaatat 1226641 gctaatagaa cgattggaca taagcaggat tatgccggaa ccgaaaaaat cagctatgtc 1226701 ccgtttcagc gggtatacaa agaactggaa aagcagcagg agaatcaaac ggcagctgaa 1226761 agaaaagtaa acgagatgaa acgtaagcgc tctctttata agagattgcg agaaaaagga 1226821 atggggacat atattaatcg atatgtataa aaaaccgttc ataccagaga acggtttttt 1226881 tatatgcagt aaaaatccgg atctcaaaag atccggatgc gttcagtcct tcatcatttg 1226941 taagtgcgga atgccggcat cgaggaattc tttttcagaa agcacgcgat acccgtgttt 1227001 cttgtaaaac ggcacagcct gtgtttgcgc gtttaaaatg aaaccggaag cgcctccgtc 1227061 tgccgcggct ttttcgagcg ctttcataat gatgccgccg acaccggctg agcggtggct 1227121 tttcagtacg caaatccgct ctaacttgcc gtagccgtcc ttcatgcgcc atcttccggc 1227181 accgacaggc ttttcaccgt catacacgac gatatgctct gactcatttt caagttcgtc 1227241 aatttcttct tcagcaggca cgttttgttc tttgacaaag acttcttctc ttacatagaa 1227301 tgcatctttc agttgttctt cattttttgc gataactgct ttcaaacatt attctcctct 1227361 gcctagcaag aaggtttcat atactgtcca cgatccgttt tccaactggt agagcaagtg 1227421 gaaacggtca acgatttctt catgcgacac ttcctgcatt tttaattgtc ccagcacatc 1227481 tgaatgctca tcgtcggaaa gattttggcc gaccgtcaca tgcggaacga aattatattc 1227541 ctgttctcct gccaacacac cggtgtatag cttttcattg agtgttttta actcttccgt 1227601 cggttctgct ttgatgtaaa tgacattatt gacaggcgca aatgagctgt attttgtcat 1227661 tttgagaacg agtgggtggg actcttttgc gatgtttctt aaatgtgata cgagctgatc 1227721 cgctttctcc tccgcgcatt caaaggatgc tctcagcgtc aaatgaggcg ggattagaga 1227781 gtagcttggg tcatagcgct ttctgtaaga gtttgcaagg tcttggagct tttttgatgg 1227841 aaataaaacg attccgtatt tcatattatg tccctcctgg aaataaagta tgatagagtg 1227901 ttaaagcatt tttttcagcg ccggggtgat gagcggctgc cagtatgtcc atttgtggtc 1227961 tccgtcaaat ggctcgaaat cataatcgga aagctttttc tccagcagct gtttcagctc 1228021 ccggttcggt tctgtaaagt ccagaatgtt cccgtctgtc gtgtggacgt cagtttcttt 1228081 tgttccgatt tggtgataaa tagagaggtg tttgatatcg tctgactgtt ttacggcttc 1228141 tagtacgtgt ttgtcaacat agggagactg catgatgatg ttgccaaaca tattcggata 1228201 atcaagcgct gtcataagtg acacggttgc tccgagcgaa tcaccgatca gcgttcggcc 1228261 gtaaccgatc tgataggttg gatactcatc atctgcaaaa ggaacgagct catgggcgat 1228321 gaaccgttta taagccgaaa attttgaacc ctccggatga taagtgtttc tgcgctcttt 1228381 tacatcctta tagggaacac cgataataat gctccggtct atttcgcgtt tcgacagcaa 1228441 ttcctcaacc tgtctgccga ttctccccag cctgaaataa tcgtggccgt cctgcgcgat 1228501 aatgacatgg tatttataaa gcggggagta gttggacggc agataaacaa gcaaggtcat 1228561 ttcctcgtta agctcttttg aaaagaattt cttttcttgc actgtgccgt ttttcggtgc 1228621 cataaaaaca ttcctccagg acatcactat actttcttgc attttcaatt attgtaccat 1228681 gaattattag aaatttctct ctttaaacgg ttcggcacac gaagaaaaaa gtgttgaaat 1228741 aaactgtgaa ttgcgctaat ataaaacaat cagaaaattg aaatcgatat ttcttatcgt 1228801 gagaggtgga gggactggcc cttagaaacc tcagcaaccg gcttgttttg catttgcaaa 1228861 gcgccaaggt gctaaatcca gcaagcgttt tttatgcttg gaagataaga agaagcgtta 1228921 aaccccttct tcttatgaag aaggggtttt tattttgaaa agggaaggtg tcagctatat 1228981 gtcacagcac gttgaaacga aattagctca aattgggaac cgtagcgatg aagtcacggg 1229041 aacagtgagt gctcctatct atttatcaac agcataccgc cacagaggga tcggagaatc 1229101 taccggattt gattatgtcc gcacaaaaaa tccgacacgc cagcttgttg aggacgcgat 1229161 cgctaactta gaaaacggcg cgagagggct tgcctttagt tcgggaatgg ctgctatcca 1229221 aacgattatg gcgctgttta aaagcggaga tgaactgatc gtttcatcgg acctatatgg 1229281 cggcacgtac cgtttatttg aaaatgaatg gaaaaaatac ggattgactt ttcattatga 1229341 tgatttcagc gatgaggact gtttacgctc taagattacg ccgaatacaa aagcggtgtt 1229401 tgtggaaacg ccgacaaacc ccctcatgca ggaggcggac attgaacata ttgcccggat 1229461 tacaaaggag cacggtcttc tgctgatcgt agataataca ttttatacac cggtcttgca 1229521 gcggccgctt gagctgggag ctgacattgt cattcacagc gcaaccaagt atttaggcgg 1229581 gcataacgat ctgcttgctg gacttgtcgt ggtgaaggat gagcggctcg gagaggaaat 1229641 gtttcagcat caaaatgcaa tcggcgccgt cctgccgcca tttgattcgt ggcttctgat 1229701 gagaggaatg aagacgctga gcctcagaat gcgccagcat caggcaaacg cgcaggagct 1229761 tgcggcgttt ttagaagagc aggaagaaat ttcggatgtg ctgtatcccg gaaaaggcgg 1229821 catgctgtcc ttccgtctgc aaaaagaaga atgggtcaat ccgtttttaa aagcactgaa 1229881 gaccatttgt tttgcagaaa gcctcggcgg ggtggaaagc tttattacat accctgcgac 1229941 ccagacgcac atggatattc ctgaagagat ccgcatcgca aacggggtgt gcaatcggtt 1230001 gctgcgcttt tctgtcggta ttgaacatgc ggaagattta aaagaggatc taaaacaggc 1230061 attatgtcag gtcaaagagg gagctgtttc atttgagtaa acacaattgg acgctggaaa 1230121 cccagctcgt gcacaatcca tttaaaacag acggcggaac cggggcagtc agtgtaccga 1230181 ttcagcacgc ctcgactttt caccaatctt catttgaaga gttcggggca tatgattaca 1230241 gccgctctgg cacgccgaca agaacagctc tcgaagaaac aattgccgca ctggaaggcg 1230301 gaacaagagg atttgctttc agttcaggca tggctgccat ctcaacagca tttttactgc 1230361 tgtcacaggg tgatcacgtt cttgtgacag aagatgtata cggcggaacc ttccgtatgg 1230421 tgacagaggt gctgacccgg tttggcattg agcatacgtt tgtcgacatg acggatcgta 1230481 atgaagtggc gcggagcatc aagccgaaca caaaggtcat ttatatggag acgccatcaa 1230541 atccgacact tgggattacg gatattaaag cagttgttca gcttgcaaaa gaaaacggct 1230601 gcctgacctt tctggacaat acattcatga cgccggcact gcagcgtccg cttgatctcg 1230661 gcgtggatat tgtacttcac agcgcgacaa aattcttaag cggacacagc gatgtgctct 1230721 caggtttggc tgctgtcaaa gatgaagagc ttgggaagca gctgtataag ctacaaaacg 1230781 cgttcggcgc cgtccttggc gtgcaagatt gctggcttgt cctgcgcgga ttaaaaacat 1230841 tgcaggtccg tttagagaaa gcgagtcaaa cagctcagcg gcttgcggaa tttttccaga 1230901 agcacccggc ggtcaagcgc gtgtattatc cgggactggc tgatcatccc ggcgctgaaa 1230961 cccataaaag ccagtcaacg ggagcgggcg ccgtgctatc ttttgagctt gaaagcaaag 1231021 aggccgttaa gaagttagtc gagaatgtgt cactcccagt cttcgctgtc agccttggcg 1231081 ccgtggaatc gattttgtcc tatccggcaa cgatgtctca tgcggcaatg cctaaggaag 1231141 agcgtgaaaa acgcggtatc actgatggcc tgctccgtct gagtgtcggc gtcgaacatg 1231201 cagacgattt agaacacgat ttcgaacaag cgctgaaaga aattgctcca gtttcggttc 1231261 gttaaaaaag aagccgggga tagtccggct tcttttatta ttgttcgtca tcaggattca 1231321 gaatcgcgag gacttgatga tcctcccaaa cgccattaat ttttacattt tttcgggcga 1231381 tgccttcttt atgaaatccc gctttttcta aaacacgcat ggacccgaga ttacggggca 1231441 tcacaccggc ttcaatccga tgcagtttca attcgtggaa cgcataatca acaaccaatc 1231501 tgactgcctc tgtcataatg ccctttccat tatgggcttt gtctaaaaaa tacccgatga 1231561 acgcagtttg cagcgcgcca cggatgattt gaaagagcga aaccgtcccg attaatctat 1231621 cgtctgacgc tgtaaagatg ccaaaatgat attcttcatc tttctcaagt ctttcctgat 1231681 actcggttat tcgttttctt tgcccctcaa ccgtatagta atcgtctgcg cgtatcatag 1231741 aaaactgttc gaaaaaatct cgattttcgc tttgcagccc cagattttct tcggcatccg 1231801 ttacttctaa aggtctaaca taaatggttt ttccttttaa catatagtga tctctccgtt 1231861 ctcatgtcag cattcctctt acattattct cagggaaatg caaatatcct ttttataaga 1231921 aggaagaaaa ccaatttccc ataaaagtgc caacatagtt gccgattaag tagccgagcg 1231981 taccgacaag catgatcggg gcgacaagct cccgccatcc cttggcaatt gccatcgcag 1232041 ccgcagtcgt cggtcccccg acagtagcgt tgacggcgag cagaatttct tcaagccgca 1232101 cacggaacaa ttttccggca gctaaggaaa ccgctaaatt gctaatcgca atgataaaca 1232161 cgaataatag aataagaggc gcattcgtga cgattaagcg gagatctgca ggaatgccga 1232221 tcaccacaaa aaacaaataa atcaaaaagg ttccaagctc ctgagatcca ttgagccttt 1232281 caaaaaaacg cgggaaaaga aaaatgataa gaacagttaa agacgtaaga accaggtact 1232341 gatcgccaag cgtaccggtc agcaggggat gagaaaaaat gcttttaaaa taaccggaaa 1232401 ccttcatact aaccgcaaca agcgcgaaag cggcaccggc attaaaagcg atatccttta 1232461 aggaaatatc cttccgtttc caatagcttt cagcactgtt tccgctgttt ccatcggctt 1232521 ttaccttctc ttcaaacggc atggcataat gccgctgaaa ccatttgagt gcaggaatgc 1232581 tgattaaaat aaaaaacaaa agcgccatca taaaattatc agccacaacg gtagccgaca 1232641 catattcacc aggcgtctca aattttgccg ccatcgccgc aaagttgacc ccgccgccga 1232701 tataagaggc gctgatcatc ccaccgattt tatctaagta aggaatatgc tgtttgagta 1232761 gaaaaaaagc caggatactg ccaagcactg ttccaacgga gctaatcaga aaaataaaca 1232821 gcaaacgcct gctttcctta aaaatttgcc taacattgat ctgaaacaat aaaagtggta 1232881 tcgccagcgg taccacataa gaccacacag tgtcatacac gggcgactca acaggaagca 1232941 ctcctacatt tgtaaacacc atagcacctg caagggcgat aatagcgccc gacacagcag 1233001 acgcccactt aaagcgctgc tccagcccga tgctcactgc cgcccacacc gcaataaacc 1233061 cccataatac ccatacatca tcagaagaaa tcaaagaatg caaaacccca tcacctctat 1233121 tgttagaaaa ttaagacata ttataatagc cggggaacgg aacagcaagt ccaaaaaaag 1233181 tttttctaaa aaagcagttg acgaatagaa ggtaaggtta tataatagaa cttgtcagaa 1233241 agataacaac atacccagca acacatacat atcatgattc cgtagctcag ctgggagagc 1233301 gctaccttga cagggtagag gtcgctggtt cgagcccagt cggaatcata gcttaaaccc 1233361 ttgcgcagca agggtttttt actttgcgtt aataaagccg gttcgtcaaa ttcgtgagtt 1233421 gttggcgaac tgttggcgaa attcattgac cgcagtccaa aaactacctc caaacttact 1233481 tgattagttc aatagtaaca aacggaagat cggatttctg ttaaatcttc attgagaata 1233541 gccagtccaa gaccgtcact tcagccatgc atcttttaaa tgaaattttg tactgaaaac 1233601 atcaattgta tttttaaatt ctgctctaga atcagcccct ttataataat cttgataaat 1233661 tgcttggggt gatactgatt cgtgatttgt gctatggttt gcaaggcttg tagcaaaagc 1233721 aggagcaaca gtaacgagta aagcaaggga taatgcaaaa ccagttaaag ctttttcaat 1233781 ttcattttaa gcacttcttt ttttaaaata caactttatt attaaatgga atacaaaaac 1233841 atccaaggtg tttttttgtt agtaagttga gttaggggga ttggatggca cttagaatat 1233901 tgtttctgct gatgggatgt tgattctgga tatatttcca acacgattac aggccggaca 1233961 tgaaagcgaa ccttgctttg atcggggcaa tcatttcatt tacggctgcg gtttacttta 1234021 aagatattga tgtattgaga gaagagggaa aacaaatgaa cggaatttct gagcgttgga 1234081 acacgtttaa attacaaaaa tcccctgaac cactctagat caggggattg ctttcccaac 1234141 agcttattaa gtagcggaag gcatgatcaa cgatttagta tcaatttatt aattgcgaat 1234201 actagaaaca taccgttttc cgccttcctt agaagtaaca tattctcgag gaacattaag 1234261 tctattggta gaatgataac ttacataaag tttcatattt gctcggctcg ttacgatagc 1234321 cgtatgatcc atccaaccat cagcatagcg aagacctatt ttattatggt aatcatagtg 1234381 atatacatct ccaagcttta catttgaata tgtatcagaa acagtcttca tttttattcc 1234441 gccagctttt aaaatgtatg atctaaaggc tcctgcatta acccaagcat ctgtataggg 1234501 tttccattct ttaaagtacg gcattcttcc agctcttaat gcttgggaaa caaagttagt 1234561 acaatctttg tctttataat atttatagtt tttatttggt tttaaggcat atttttctgc 1234621 atatttcatt gcagcgtaac cactatatcc tttaacagat gttgcagtca cagttagttg 1234681 attagagtta gcagcattga agttcatact tactggttta tcttcacttt tcacttcttc 1234741 tttatcatca tttttcactt cttgcttata tttttttaaa aattcatcta atttaacatc 1234801 cgaagaatat tcttcatcat tttcatattg tagagttgaa gaagaattat ttaattgtgt 1234861 tacatttagt tgcttagaag aattactcaa tggtattaca tttagttgat tagaagaatt 1234921 tttaacttga gagaaactta gattagaagt atttgttgat tgagaacttt gtttattaga 1234981 agttgttttg ggaatttcaa gtttaatatt atcgcccaga gatgttgtta ctttttcaac 1235041 accaaaaaca aagtttcgag taatataagc ttcaacaatt agcttattgt ttttttcaga 1235101 agtcttaaca tcgtctatat cgtatgtaaa ctcgtggaat ttttgtttgt ccactttact 1235161 taacgcagaa tacagtaaga ctccttcgtc ggaatcagtc aatttagact ctttaggatg 1235221 cgctaaagga gtgttgtgtt caaaatcata tttttgttgt tctaacatat ccttaacttt 1235281 ttcgtaacca atctcgttgg taattgaaac attttcttta gtctctttat tagtagtggc 1235341 tgcaaaaact tcatttgttg acactaatgg tgacaatgat agacataaaa ctagtgaagc 1235401 aagtaattct tttttcatac gaaacctcca ataaaatcta aatataagta atatttatca 1235461 tttacaccaa ttgaaatatg gcataaaata catgtaataa tataacataa aaataaatac 1235521 ataaaaaggt atcggaggaa aaaatgaaaa agaaaactaa aattatactt tctctcttgg 1235581 cagcacttat tgttatattg atagtacttc cagttctatc tcctgttgtc tttacagctt 1235641 cttcggaaaa aggagcaatc agacacgaaa tttataaaag aggatatccc taccaaagct 1235701 actttgcagt tctccagaaa agagaaggag acaatgaatc tgggaatctt tattatgtaa 1235761 attggctaga ttggaaagat gaaacagggc aaactcctca cttatgctat tcgaaaaaat 1235821 catcagatgg tgaatacgaa gtaagttgtg gcacagggcc gtaaaaataa attttaaaat 1235881 tgaataagtc caagacggaa agcctgcgga cactgatcgt tttacagaga aatttgtgct 1235941 tcgatcggtg tccgtttttt ttcgcaacta accagatgtc tatcgcgatt actagctatg 1236001 aaaggagtaa ttagacatga aacagtccaa aaagaaacca tcacagaagc aacatgagcg 1236061 cttagatcgt ttctggcaac aaatgatgaa cactaacatg caaacactca gacgtggcaa 1236121 aggcggcgct tataaacgca gaaagtaaaa agggagtttg aggatgatga aaaacggatt 1236181 cgcttataaa aacggaaagc ttgtgaatat cttttgcggc aaagaagagc tctataacga 1236241 gttgaaagcc ttcttggtca aaaccttcag tatcaacgtg aaagaggtat cgaggccctc 1236301 aatatatcgc agaacaaaaa gcaaacaact ggaatgacac ttactctatt taactatcag 1236361 gagggaaagc actatgacag atcaaatgat tgcatgggag attgaggaat ggattcgtga 1236421 ttataaattc atgctgcggg agatcaaaag gctcaaccgt gtattaaaca aagtggattt 1236481 tattagcaca aagctcactg caacatacgg ggaggaagcg ggcatgccaa ggggatcagc 1236541 aggcgtcagt caggcagaat tgcggcagat ggaccgaaga gaaaggcggc ttcacaaata 1236601 tgaatctatt gtgcattacc tggacaatgc aatggaacac attgaagaag aaaagcaccg 1236661 aatcgtttac gattgcatga tggaaggcat gagctacact gctattgcaa accaccttga 1236721 ttgctcccgg gataccatca gaaagatcaa aacagccata atcggcaaca tcgtcaataa 1236781 agtcaaagaa gccaactttc tgcaatattt gaattcgttt aaatcggcgg tgtaaaatgg 1236841 ggggcaggat cggcgcggcg gattattcct gcgtcaccac caatttcata caatgagtaa 1236901 aacctcccag tggtaagcga ggatcaactc aactgggagg tcttacatag tgaatcggtg 1236961 ataaaacagc agcagtattg cgtacatgtt aatatccccg acaaaatatg tttttttcaa 1237021 cagattcgtt cgacaaattt tgcaaattgt taatcgataa cttttcattc ccgatattaa 1237081 aaatgggagt gaattgtaaa atgaaaaaac agaaaaataa taaaaagaag aatattgaaa 1237141 agcgaaatat tgaaaagcga aatattgaag agaagaataa tgaggactta gaagaactgg 1237201 aaaatgcgat ttatacttat cacaaaaagg agctacttgc tttctttctt gaaaaaactc 1237261 gaattggtca tgataaggaa gaatacaaaa ggttccaatc tcttctttat aagttggata 1237321 ttgaatgttt agaatttgct atatcgagat tttctcatat agatattatc catgatcatt 1237381 caaaatatgt tccagccttt atccctttat ttgcagcata tctcaccatg ttctttaatt 1237441 tttatgaaaa acattgggga gctttatctt ttgctgctgg tacaattgct gctattgttt 1237501 ggataattgc agtagaaaga aaacatagaa atcaagcaat ttctattatg aaaatatttg 1237561 aacaagtcaa agagagaaaa gtgaaagaca gatctaaaga ctgaaaggag aaaatatgaa 1237621 taaggataaa ttaaggtatg caatcttaaa agaaattttt gaaggtaata cccctttgtc 1237681 agaaaacgat attggagtta ctgaagatca atttgatgat gctgtgaact ttttaaaacg 1237741 cgaagggtat atcattgggg tccattattc agatgataga cctcatttat acaaattagg 1237801 acctgaactg acagagaaag gtgaaaacta cttgaaagag aatggaacat ggtctaaggc 1237861 ctataagacc attaaagaga ttaaagattg gattaaataa taagagcatc ctgcggggtg 1237921 ctttttttgt tccctgtaaa ctgcttccgg taagtctcag gatagacaat tggcggttaa 1237981 cggcttgagc acggtggtgg tttagaggga atatcttttc caaaacaaca cgaatcagaa 1238041 gggggcggcg gtgaatgtag atggccgaaa agcacattca ggcgtataag gattacgtca 1238101 aaggcatgaa atacaaggac cttgccgaga aatacggggt gtcagtgaac accattaaat 1238161 cgtggaagca gcggcatggt tgggaaagga aaaagggtgc acccattgaa aaaagtgtgc 1238221 acacaaaaaa aggcgggcaa ccgggcaaca aaaatgcatt agggaacaat ggcggcgcac 1238281 cacagaagaa tcaaaatgct gtgactcacg gctttttctc taaattcttg ccagaagaga 1238341 cgcttgaaat catggaagag attcaggagc gttcgccagc tgatatgata tgggatcaga 1238401 tacagattca atatgcggcc attcttcggg cgcaaaagat catgttcgtt tctgataagg 1238461 aagaaatgat caaagagctg aaaaagaaaa ggtccctcat atctgaggtc agcgaaattg 1238521 aagatgggct tgtcattagt tttagtacgt ggtttcgcta cagactttac agtgaaacaa 1238581 acacctaaca catttcacat tgcttcagat tgccttcaaa cttgataata taacttctaa 1238641 accttcctat aaaatgaagg ttttttattt gatttcaatt tttaaatcct ttacatacag 1238701 cgattgatta actcgagcaa tcaatgtcgc agttatattt atttttcaag aaaatgttat 1238761 aatgaaaagc cataaaatga tgggaggggg aatttcgatg cattacataa cggcatgttt 1238821 aaaaatcatc agtgataaag accttaatga gataatgaag gaattcaaaa aacttgagga 1238881 agaaacgaac aaagaagagg gttgtattac attccatgct tatccgcttg agccatcaga 1238941 acgtaaaata atgctttggg agatttggga aaacgaagaa gctgtgaaaa tccatttcac 1239001 aaaaaaacac acaatagacg ttcaaaaaca agaattaacg gaagtagaat ggttaatgaa 1239061 aagcaatgtg aatgattgaa aggctcttta aaaagagaca ttcaatgact tagtatcagc 1239121 cacttgtgac taagtagtaa attgttgtcc aactcttatt ttttctattt aatatttttt 1239181 gagacgaaaa tgttttttta agctgatttt aaaatgtatt caaagtcagc tctgtttgat 1239241 ttaatggatt atattatttg gatagcttgt taccatcata atggagatac tccttataaa 1239301 ttggaggtta aaataatgag tcattctcaa gaaaaaattg cactaattac aggagcaagc 1239361 agtcaagggg atattggtac ggctatttgt cgtaagttag cctcacaggg tatacatatc 1239421 ttctttactc actggaattc tgatacggcc tggatagaag aatttcaaca agaaatttta 1239481 cgtatgggtg tccgctgtga ggcaatgaaa attgatttat cagatgcaca tgctgcattc 1239541 acaatacatg aaaaaatttc agataaatta ggatatcctt ccatccttat taataatgca 1239601 gctcattccg caagtgataa ttatgtatcg ttagatgcta aatcacttga tgagcattat 1239661 gcggttaata tgagatcgaa ttttcttctt tgtgttgaat tcgcccgtcg gtttaaaaaa 1239721 tctaatttaa tatcaggaag aatcatcaat atgacatcag ggcaggattt aggtcctttg 1239781 cctggggagt tagcgtatgc agcaactaaa ggagctattt ctgcatttac taggtcgtta 1239841 tcacaagaac ttgcaccatt gggcatcact gttaacgccg taaacccagg tccaacagat 1239901 tctacatgga tgacagatga aataagaaat tttctttcac ctaaatttcc aatggggcgt 1239961 attggcacac cagatgatgc agcacgaatg attgcctttc ttgcaagtga tgaggctgaa 1240021 tggataactg gacaaattat tcattcagaa ggtggattta ttcggggcta agctaatgaa 1240081 acacggtata caccaatgta tgatgtattc ccaaaactaa atctaaactt gaagcgaaaa 1240141 taaggtccct tctcttttta gagggggacc ttattttatt catgcatgtt ttgcatccag 1240201 aaaatctggc ggataaagat taataaaccg ttacatatac ttttccgaat actgcagtac 1240261 ctttaaacaa agtaatcgtg gctttccctt ttgatttagc cgtcactaaa ccattttgat 1240321 cgacttcagc aactttttgg ttatcagtcc aataacgagt agctgaatta tttttaacag 1240381 aataggtttc tccaactttt agaggtaaat tatagtcttg aatcttgata acatgtgtag 1240441 gtgaaataga aatgttcttt acttcagtag gtgtggagtt tatttcatga gctgaagcta 1240501 ccccgctgac cgacagagct aacgcagaaa tcgataaagc agaaacaacc gtttttttga 1240561 aattcatttt gaaacactcc tttaaagttt tttgtcttgc actataacaa ttcaataaaa 1240621 gtaattattt tccttgtaaa taaatgttaa taatatgtga acgatcaatt gatttgagct 1240681 aagaatattg tgtgccctgc acagagtttg tatttatgat ggaaaattgc tgagagagaa 1240741 tggccatcct taaaatgtta atagcacaca tttgatgggt attagtttgt tgagcgtgtg 1240801 gaaattttgt tacctgcact ttatccccga agataccaaa tcacttttct tcatcatgtt 1240861 cttactttcg tactcataca ttagaaaatc ttcgttctaa ataggtgaag aattggagta 1240921 tttttatgaa tttctgctga atatacatta catagcaaac tcaaagagta taaaaatcgc 1240981 ttttttccgg aagcttcggt aaaaaacgaa acttttgtct ctatgatttt gttttataat 1241041 gtaaacggtt tcttatatag tatacttata ctatcaattt gctcaagtag atactgacag 1241101 gaaggataga aaaacagatg gaatacataa atacaagaca aaaagagatt ttgtatctgt 1241161 tgttatctga acctgatgac tatttagttg tgcaagattt cgcagatagg gtacagtgtt 1241221 ctgaaaaaac aatccggaat gatttgaaag tgatcgagga ttatctcaat gagcattctc 1241281 atgcacagct tattcgaaaa ccagggttgg gcgtttattt acatatagaa gaacaggaaa 1241341 ggacctggct aagccaacaa ttacatactg aacatttttc ttctaggcag cggagcgata 1241401 aggaaagaat gctgcacatt gcttatgact tattaatgaa tccgaagcct gtttccgcaa 1241461 aagacattgc cgctcggcat tttgtcaatc gatcttccat taaaaaggat ttatacgcag 1241521 tagaagagtg gctgaagcgt tttgatctca cactggtttc taggcagcgg cttggattaa 1241581 aggttgaagg gaacgaaaga aataaaagaa aggcattggc aagaatatct gatttgattc 1241641 acaatacagc gtttaccagc caatttatta aaagtaagtt tttacattat gaagtagact 1241701 ttgtgacgaa agaaatcaaa tcactacaaa aaaagcattc cctctatttc acagacgaaa 1241761 cgtttgaaag tttgttgctg catacattgt taatggtccg ccgcatcaaa atgaagcagc 1241821 cgatttcatt gtccccaaaa gaaatggcgg cagtaaaaaa gaagaaagaa tatcaatgga 1241881 catttgcttg tttacagcgg cttgaaccgg tttttgcaat tcgcttccct gaagaagaag 1241941 ccgtgtactt aacattacat atattgggcg gtaaggttcg ttatccattg cagacagaag 1242001 agaaccttga aaatgctgtg cttcctaagg ttgtagggca tttaatcaat cgtgtttcag 1242061 agctgaaaat gatggatttt cacaaggatc aggatttgat caatggtttg aacattcatc 1242121 tcaatactgt gctacaacgg ctgagctacg atctttctgt agcaaatcct atgctcaatg 1242181 acatcaaaaa gatgtaccct tatttgttcc acctcatcat tgatgttttg gaagacatca 1242241 atcaaacttt tgatcttcat attcctgagg aagaggcagc atatttgaca ttgcattttc 1242301 aggcagcgat cgaacggatg cagggcagca gcgagacaca taaaaaggcg gttatcgtct 1242361 gccacatggg gattgggatg tcacaattgc tgcggacaaa aattgaacgg aaatatcacc 1242421 aaatcgctgt aatggcttgt attgcaaagg ccgatttaaa ggattatatc aaaaagcatg 1242481 aggatattga tcttgtcata tccaccattg cgctggagaa tataacggtt ccccatattg 1242541 ttgtgtctcc gcttttagag cctggcgaag agaagaaatt aagtgcgttt atacgtcagc 1242601 tgggcgaatc acaccgccaa aaacaaaaaa cgtttcagat gctgaacaat acgactcctt 1242661 ttttggtttt tttgcagcag gaggcggagc atcgctacaa gttaatcgaa cagctggcga 1242721 cagctttgtt tgagaaaggc tatgttgata aggactatgc ggttcatgcg gtgatgaggg 1242781 aaaaaatgtc ggctacaaat attgggtcag gcattgccat tcctcatgca aacgctaaat 1242841 ttattaaaca atcagcaatc gcgattgcca cattaaagga gccgcttgaa tggggaaatg 1242901 aaaaagtttc gctcgttttt atgctggctg tcaaacacga ggatcaaact atgacaaagc 1242961 agctgtttag cgagctttca tatcttagcg agcagccggc cttcgtccag aagctgacga 1243021 aagaaaccaa tgtcatgaca tttttatctc atttggatta ttaaaagcag ggattattcc 1243081 ttgctttttt tgttataggg aaaaatgcct ttattaccgg aacctatggt aaaaaaagcg 1243141 attttaatga gctgatttcg gtatacagtt gagacaagat cttattattc acactttaaa 1243201 ggaggtttcc tatgaaactg ttagcgatta catcttgtcc gaatggaatc gcccatacgt 1243261 atatggcagc agaaaatctg caaaaagctg ctgacagact gggcgttagc atcaaagttg 1243321 agacccaggg agggattggt gttgaaaata agctaaccga agaggaaatt cgcgaagcgg 1243381 acgcaatcat tattgctgca gaccgttcgg taaacaaaga ccggtttata ggcaaaaaac 1243441 tgctgtctgt gggggtacag gacggtatcc gcaaaccgga agaattgatt caaaaagctc 1243501 ttaacgggga tataccggtc tatcgttccg ctacaaaatc ggaatccggt aatcatcagg 1243561 agaagaaaca aaatccaatt taccgtcatt taatgaacgg cgtttcattt atggttcctt 1243621 tcattgttgt cggcggatta ttgatagcgg ttgcattaac gcttggaggg gagaaaacac 1243681 ctaaaggctt agttattccg gatgattcct tctggaaaac gattgaacag atcggcagtg 1243741 cttcattttc atttatgatt ccgattttag ccggctatat cgcctatagc atcgctgata 1243801 aaccggggct tgtgccaggt atgatcggcg gttatattgc ggcgactgga agtttttatg 1243861 acagcgcaag cggcgccgga ttcctcgggg ggattattgc cgggtttttg gccggatacg 1243921 cggcactttg gatcaaaaaa ttaaaagttc caaaagccat ccagccgatt atgccgatta 1243981 ttattattcc ggtgtttgca tcactgattg taggtttagc gtttgtgttt ttgatcggcg 1244041 cgcctgtagc tcaaattttc gcctctttaa cagtttggct ggcggggatg aaagggtcga 1244101 gctcgatcct tctggcattg attttagggg cgatgatctc atttgatatg ggcggtcccg 1244161 taaataaggt ggcgtttctg tttggatcgg caatgattgg agaaggaaat tatgaaatta 1244221 tgggaccaat tgctgtcgcc atttgtatcc ccccgattgg ccttggcatt gcgacgtttt 1244281 taggaaaaag aaaattcgag gcatctcaaa gagaaatggg gaaagcggca tttacgatgg 1244341 ggctcttcgg cattactgaa ggagcgattc catttgcggc gcaggaccct ctgcgcgtta 1244401 ttccaagtat tatggcaggc tcaatgacag gttctgtgat agccatgatt ggcaatgtgg 1244461 gagacagagt ggcgcacggc ggacctatcg ttgcagtgct tggcgcagtt gatcatgtct 1244521 tgatgttttt tattgctgtg attgcaggat ctcttgtcac tgctctgttc gtcaatgtac 1244581 taaaaaagga tattacggcg tctcctgtgc tcagtgaaac tgcaccgacc tccgcgccaa 1244641 gtgaagctgc ggcagcaaat gaaataaagc agccaattca aagccaaaaa gctgagatgt 1244701 cggaatttaa aaaactgaca gacattatca gcccggaatt aattgaacca aatttatcgg 1244761 gggaaacgag tgatgacatc atagatgaat tgattcagaa attgtcacga agaggtgcgc 1244821 tgctttcaga gagcgggttt aaacaagcca ttttgaatcg tgaacaacag ggaacaacgg 1244881 cgattggcat gaatatcgcg attccgcacg gaaagtctga ggcggtcagg gagccgagtg 1244941 ttgcctttgg gatcaaacga tcaggcgttg attggaatag cctggatgga tcagaagcta 1245001 aattaatctt tatgattgct gtaccgaaag agagcggggg aaaccagcat ctcaaaatac 1245061 tgcagatgct atctcgaaag ctaatggatg acaattatag ggagcggctg ctctccgtgc 1245121 aaacaacaga agaagcatac aagctgctag aagaaatcga ataaagcggg ggattttcat 1245181 gacgactgaa ccgttatttt tcaagcctgt tttcaaagaa agaatttggg gcgggaccgc 1245241 tttagctgat tttggctata ccattccgtc acaacgaaca ggggagtgct gggcttttgc 1245301 cgcgcatcaa aatggtcaaa gcgttgttca aaacggaatg tataaggggt tcacgctcag 1245361 cgaattatgg gaacatcaca gacatttatt cggacagctt gaaggggacc gtttccctct 1245421 gcttacaaaa atattagatg ctgaccagga cttatctgtt caggtgcatc cgaatgatga 1245481 atatgccaac atacatgaaa acggtgagct tggaaaaaca gaatgctggt acattattga 1245541 ttgccaaaaa gatgccgaga ttatttatgg ccacaatgca acaacaaagg aagaactaac 1245601 taccatgata gagcgtggag aatgggatga gctcttgcgc cgtgtaaagg taaagccggg 1245661 ggattttttc tatgtgccaa gcggtactgt tcatgcgatt ggaaaaggaa ttcttgcttt 1245721 ggagacgcag cagaactcag acacaaccta cagattatat gattatgacc gaaaagatgc 1245781 agaaggcaag ctgcgcgagc ttcatctgaa aaagagcatt gaagtgatag aggtcccgtc 1245841 tattccagaa cggcatacag ttcaccatga acaaattgag gatttgctta caacgacatt 1245901 gattgaatgc gcttactttt cggtggggaa atggaactta tcaggatcag caagcttaaa 1245961 gcagcaaaaa ccattccttc ttatcagtgt gattgaaggg gagggccgta tgatctctgg 1246021 tgagtatgtc tatcctttca aaaaaggaga tcatatgttg ctgccttacg gtcttggaga 1246081 atttaaactc gaaggatatg cagaatgtat cgtctcccat ctgtaacatg gcagggcttg 1246141 agaaataaat ttgcgagtga agacgcctat tctccagcaa tgatctaaat aaaataagag 1246201 tttaatagtt ggagaagaaa tgttacactc ttttctgtat atggtaaaga atgaaaaaac 1246261 acgattcggt tggtagtccg gatgcatgat tgagaatgtc agtaaccttc ccctcctcgg 1246321 gatgtccatc attctttaat atcttttatg aggagggaat cgttatgaaa ttaacgattt 1246381 actacgatgg tcagttttgg gtaggcgttg ttgaagttgt ggacaatgga aagctaagag 1246441 cctttcgtca tctttttggc aaagagccga gggattctga agtattagag tttgttcata 1246501 accaactttt gaatatgatg gcccaagctg agcaggaagg agtgcgttta caaggcaggc 1246561 gtcaaaaaaa gatcaatcca aaaagattgc agcgccaggt ttcaaaagag ttgaaaaacg 1246621 ccggagtaac ttctaaagct caagaggcga taaagctaga gcttgaagca agaaagcaaa 1246681 agaaaaaaca aataatgaaa gaacaacgag aacatgtaaa agagcaaagg tatatgctca 1246741 aaaagcaaaa agcgaaaaag aagcacagag gtaaataatc caaacaaaag caggcgcagt 1246801 gcctgctttt gtaattaagg actctacttt gtaacatata tccaatgttt atactccgct 1246861 gatttatgat tcaatataaa ccctaacttc tccaaggttt tttgtgagcc tagattatca 1246921 tgttcgcatc ttgcggtgat ccgggatact gtttctcggc ttaatgccca gtttattagt 1246981 ttttgggcgg cttccacaca ataacctttg cggcgatgac ttttatttgt tgcaaaaccg 1247041 atttcaatca tgccattttc gtctgggtca cctaaaaatc cagttccccc aacaatttca 1247101 taattgtcct tctttacaat aatccatgaa tcaaatcctt ttgttccatt gtttttgact 1247161 aaaatctcgc ggaaataagg tatcgcttca aaaaaatcag aatttggcca ttcaccattt 1247221 gtttcatagc ctaattcttt gatagcctga tgatcttgtt tagacgcggc gtcaagaagg 1247281 ggaatatcaa tcgtttgtaa tcgtaatcga ttcgtttcaa ggagaaccat atatttaatc 1247341 ctcttttctt tttactggga ataatgataa catataacaa ttttctctgg taccttggca 1247401 gtagagaaag atgaaaaaat tgagggggat tgaaagagtg acaggtgaga gtttgcccag 1247461 accaaaaacg ggtaggaaaa tgctgatgtt aatgtgtccc tacccgtttt tctgttcctg 1247521 aatgcagggt ttctgataac atgttgtgct accttttcgc aatcaaataa agcgatatgg 1247581 ctctttgggt ttgcacagga ttatgaatga taatgaccca ttggtttctt cgtcttggaa 1247641 agcttgctac cgcatacaat ggagcagtat cgcgcggagt gaacccacca tttatcacgt 1247701 tgatatctct tccttcaaga tgacaaacta agtattcacc tggattgatg acctgttggt 1247761 tcgtccatgc gtaagaataa aagccgtctc caagatcttc ggtggaagat ggggggacaa 1247821 agccatctac agtcaatgtg atttctcttc ttcgctgtct ttctgaaaag tctggacttc 1247881 tttgagggtt atgagtatgt gaaaagtaag gaattaacgc agggccataa aagtaatgat 1247941 acaaagcaac cactccttta ttttccattc atacaaattg tatgtgggag ttatttgttc 1248001 attcctgttt tgttccatgt agactaataa tgggctatag gcgtccaagg aaatcaattt 1248061 gtccttccgt tgattcaatg ctagtaacct tgaaaatgca ggttaggatg atagaattta 1248121 catattactg caagaagtta gacatacatc attttgatag tgggtgaaaa caatggcgaa 1248181 aaaaatggca aaaacaaatg cggttcgtct gatagaacag cagaacatct cttatgaggt 1248241 attagggtat aaaacagacg gccagccggt agatggcatc tctgttgcgg aaaaaatcgg 1248301 ttattctttg aaatatgtat ataaaacgtt ggttgcagca gcaggaacaa atcattatta 1248361 tgtctttgtt gtacccgttg cagaagagtt agatgtaaaa aaggcagcaa aggtgacagg 1248421 ggaaaagaaa atagaaatga ttgcaatgaa ggagctgtta gcggtaactg gctatcttcg 1248481 cggcggctgc tcgccaattg gcatgaaaaa attgttcccg acctatattg atgcatctgc 1248541 agaaacgctt gattttatta ttgtcagtgc agggaaaatc ggtatgcagc taaagttggc 1248601 gccacaagat ttagccagat catgtgatgc cgcatttgca gaaattgtat agatgcagat 1248661 ataggggaac gaaaaagctt agtcatatcg attaagcttt ttccgcatcc ctttcaaata 1248721 tgatttcaaa ataagcagct gccccatacc catctatact gggagcgaaa atctgaacga 1248781 atctccagcc tcttttcgca taatcatgga tgatttgctg gtagtcttct ttaggccttc 1248841 ttctcatcgt actcagctca actcttacga attcatattc tttcatcgtt tgatccctcc 1248901 tattaaggta tacgtaaaat ggagcgagaa gttccgaaaa cctaggttaa ggtcggaaag 1248961 tatatttcac tcactaaaca aatccattta tgcctgatgc ctgcatgcat ctgggaagag 1249021 ttaaggggct ataaaaacga attttaccgg gtcagcagtc caaatgaatc tcttgcttat 1249081 tgcatttgac tgagtatata agtaaaaaaa gagcggccag aacatataag aaggagatga 1249141 tcattaacgc actcataaca gggtagtgtt tagcggagta gatgaaaaaa tcaagctgtg 1249201 aaatttgttt ggggctgctg acggcatcaa ttccattaag cagttttgag agtttagcag 1249261 tatagttcca atcaaatcga tctgaaacaa gctcgcttcc ttgataccaa ttaacagcag 1249321 ctaaaaacag aaataccata atagaaaatc caagctgaac aactaaaaat attcccttca 1249381 cttttgtatg acctccaaat ctatgaatat gggaaaatca aacaatatat taccaccgta 1249441 tgggttattc ttgcaatttc acttccatac aactcaaacg caagtctatt tttttgtttg 1249501 tttttggctt ataatacctg atgatggaaa aagagtgcgg gtttatagat tagagaaaca 1249561 aatgtatttc ttagcatttt ttatttgtgg agagagtata gaagcattcg attagatctg 1249621 ctttttcaca gaaacggttt tcatctgttt gcctgagctt tacaattggc tggcaaaaaa 1249681 acaatgattt ctttcaatca aaacatgcaa cgatgcgaca cattttatat cttgatgact 1249741 tatttcattg cctttaagtc atcctatcga gaaagcgatg gtattttatg aacaaagaaa 1249801 ccctaaaaaa catactcatg attttttcaa tatgcgcaac actccgagaa accgatggta 1249861 tgcgcatagc tgatagctgg attttgagtg agattatacg atttttgatt tgcatggttg 1249921 tgttttttgc catgacattt ctattagatg ctgtttttcc aaacaaaaaa gagtcacatt 1249981 aatgtgtggc tctttttgca tcatctgatc agaaacatca taaatgaatc gatcatcatg 1250041 atgaagaaca gcaagcaaaa ataaataagc gagtagacaa acatatcctt tgcccacttc 1250101 acgtcatcgt ctgttttgaa tcctttgatg ctttttttga tccatatgcc tccgagaacc 1250161 aaggcggcta agaaataaaa tgggcttata tggccggtgc cgagagagaa aggaaataat 1250221 agcgtgaccg gcaccaggac ggcaatatat tgcatcattt ttatttttgt tacatgattg 1250281 cctttgacta ctggcaagag cggaacgcca gcagcgcgat attcctcttt gcgtcttatc 1250341 ccaatcgccc aaaaatgcgg cggctgccac agaaacataa tcgtgtacaa cagcactgct 1250401 gtcatactga agtcaccggt tacggcacaa taccccatca atggcggcgc agctcctggg 1250461 aagctcccga caaatgtgct ccacacagac gttcgtttca cccataccgt atagatgatc 1250521 gcataaaaaa taaaggcggc cagtccgaga aaggccgtta atggattgag ggaataaagc 1250581 atggcaagac ctgcgattcc taaaacagag ccatatgtta agatcatggc tggcggcatt 1250641 ttccctgtga ccgaggccct gctgcgagtt cgtgccattt ttgcgtccat atgccgatca 1250701 aaatagttgt tatagacagt gccggaagcc atcacaaacg cggttcccaa cattgctgtt 1250761 accattgtca tcaaaaaagc caagccggtt aacgtttttt ctgcgcttgc aaacgcgatc 1250821 caaaacccgc cgaaggctgc tatcgagttt gatatgataa tgcccggctt tgcaagtttg 1250881 ataaaatcgt aaatggttac ccggttcgaa gcttttatgt attttgtttc agatatggct 1250941 gcagaatctc ttgtattctc caaaaataga cgcctccccc aaaactgcat gcttttgtta 1251001 tcgtaacaag agggggacag aatcacaatt atttcccata tttgtcatga tattgtcatt 1251061 tttaaaacaa aaaaatgggg agctggactg cccccatttt gatatgtggc gactagtaac 1251121 cgtaacctcc cccatatcct ccgccataac ctccgccgta accgtaccaa gggtagtaag 1251181 gcggtcgcgg gcgcgggtag taataaggcg ggcgcggata aaacgggtag aacggataat 1251241 acggtcttgg ataataataa ggcggataaa atggcggtct cggacgcgga taataataag 1251301 gctgtctttc atcataaggg gtaatttgtt caaatgactg ttcattcaaa gggtaatcca 1251361 agaggaaaac ctccctagct ttttttattc cttttaccat attcctgatg cttaagttgg 1251421 gtgtatgtac attcatgaaa ttcggttttt tttatgatga aattccttaa aaaggattga 1251481 catgaacttc taaatctcat agtattacaa atgtgaaata aatgttacta caatgttaca 1251541 aaaacatttc taaatagata cagttccaac tgatgaagag taaatcgaaa tggctacgaa 1251601 agaaggagtt tttgttgttg gcaaaaagaa tcaaatggtt tcatgtatta atagcagttg 1251661 tatgtgtggt gggccttatc ggctttttcc ataatcattc attgaaaaaa gaaacggtca 1251721 tgaataaagt aagaactgat tctcaatatg ggaatgttga gatcgcaacg cttgtgaatg 1251781 acgggaaaac ttttaattac gcggtaaact atcctgtttt caaaaatgaa aaaatggatt 1251841 cggcattaaa aagattcgca gaaaaagagg ttcgtcaatt tcaaaaggaa acaaaggacg 1251901 ttgaccaaga gcatacgaca aaacgcaacg aattaaatgt tgattataaa attgtccatt 1251961 atgccaaaca gacagtggcg attgtattta atgaatataa atacatcggc ggggcacacg 1252021 ggcaaaccgt gaaaaaaacg tttaactatg attttagtaa acaagcgttt ctttccattg 1252081 atgatatttt caaagaggac gctgactact tacataagct ttcgttaatc gcttatcacg 1252141 agctgaaaaa gaataaggac attgccgcgg acgatgcact gttaaaggaa gggacggctc 1252201 cgaaaaaaga aaatttcagc cgctttgcca tcaaggagga ttatatcgaa ctttactttg 1252261 acacatatca ggttgcagca ggctatcttg gagagcaatc gattgccatt aagaaaagtc 1252321 ttttgaaaga cattctgaaa gaacaatata ttgataaagc aaaaaataaa aataaaatca 1252381 aagaacaaaa gccgaagcat gaagtgattt ctttacccaa agaggaaaca gttgatccaa 1252441 atcaaaaagt cattgcgctt actttcgacg acggcccgaa tcctgcgaca acaaatcaga 1252501 ttctagactc cttgaagaaa tataagggtc atgccacgtt ttttgttttg gggagcagag 1252561 ttcaatatta tccggaaacg ctaataagaa tgctgaaaga aggaaatgag gttgggaacc 1252621 attcatggag ccatccgctt ctcacaaggc tttcagtgaa agaagcgtta aagcagatca 1252681 atgatacgca agacatcatt gaaaaaataa gcggatatcg tccgacgctt gtaagacccc 1252741 catacggcgg cattaatgat gaactgcgga gtcaaatgaa aatggatgtt gcgttatggg 1252801 atgttgaccc ggaagattgg aaagaccgta acaaaaaaac aattgttgac cgtgtcatga 1252861 atcaggcggg agatggaaga accattttga ttcacgatat ttaccgcacc tctgctgatg 1252921 cggccgatga aattataaaa aagctcaccg atcaaggcta tcaattggtg acagtttctc 1252981 agcttgaaga ggttaaaaaa caaagagaag cgaaataaat tagaaaaggc tgtccgtacg 1253041 gacagccttt tttctattta ataagagcct gtggtggccc aaacatttaa gtttggtcct 1253101 gaatacttgc cgaaagcgta agaagtcctt ggatctaaat catataccat cggtgtatag 1253161 caagactttt ggccggccac cgcttttcca ttgccgcctg cagaatcaca attatatctt 1253221 tttccgtctg tgttccgggt aatctccgca tttgcttcat agccagacgt caatgtatta 1253281 ttcatcgtga tttttgccca agccgtttta catgtactgc tgaatttaag ctcgactact 1253341 ccgatgactt gattgctggc attcactaag tttgaggatt tttttgtaga gccgctggac 1253401 gcacaatcat tgtaataagg gctttttcca tcgtaggcat gggtttccgc cttggcgggt 1253461 gcacctttga cggcaaaaac aaatactact gcgaataaca ccaatgaagc cttcataaac 1253521 agtcttttca atttatgacc tccttaatat ggcaaacaat aaatcatatg gaggaacaat 1253581 caaaacatgc atgctttttt gtgaacaata aaggcggccg ggaggatgga gttcttggcc 1253641 gcctctggta tgaggttatg cttttacatc aatggtttgt ccgagagttg gatgttgaat 1253701 catctttaag gtttgatcgg cattttgctg ggcggtgtcc agcctttttt tcgttaaagc 1253761 aatatttaca ttctgggcaa gggatgcttg atgcatcgca accgataaag caggaatatc 1253821 catggttcca cctcctatgc cttacctatc ggcgggtttg tatgatttta cagtgaaaaa 1253881 tggcttaatt tctcttgttg acccttacgc tgcggcatat cgtatgtttt tgacaaggag 1253941 ggaatcagga tgaatctagt aatggaaaag acctttgagc aatacgaaaa gctgttttca 1254001 atggaagaac agaaaagaga agatgtattt cggtatacga tgatgaggcc gtttgaaaag 1254061 atgtggaccg ccatccaagt tccgctgaaa gcgaaggagc caaacggcta tgatgtgatc 1254121 atggctgcga aaatgctggg ctatttggat gtccgtgatg ctgaaagcgg ccagaaagca 1254181 ctacaaatac tgaaagaatc acatgtttca gagacagctg aatctgcact tcggcaatgc 1254241 atattttttg ctgagcgcga acagctgcgg gtgaatgcaa aggagatcaa attcggcctt 1254301 tatatcgctg atccaaataa gcttcagctg caaaaaggct actgcgggtt tggcgggata 1254361 ccgggcttta ttcatgtatg gattaatccg aacagttata acctgccaag gattccttcc 1254421 attattgctc atgagtttca tcataatgtg cggttttcgt atatagattt tcatcatggc 1254481 tctgtaagtg tcggggatta tcttgtgatt gaaggattgg cggaatcatt cgccagagag 1254541 ctgtttggta cggaacgatt gggcccttgg gtaactcgtt ttgatcatga agacttgcaa 1254601 tattccattg atgtgattaa tgaggtgctg gatgtgaaag gattttcgga agtcagccgt 1254661 tatatgtttg gtgatccaat tgctaacgac caaggcttta agcctgcagg tttatcggct 1254721 tttgcgggtt atgcagttgg ctatcatgcc gttcagtcat ttatgaatca acatcatatc 1254781 acgataagcg aggccacacg tttggatgcg aagaccatta tttctcaatg cggtctgttt 1254841 tctacatgaa aaaagcgtca catacagcgg cgctttttga ttcccaaaac cagcagttct 1254901 atggcggcac aggcggcaat tccgattgta tatgcttcga tatcgctcca taaaaaaccg 1254961 taccctagta caagcccgcc aagagaagta tctctaatct ggtcgatcca ttcggcatga 1255021 tagagctggc tgaattcaat gacaaaacag aaagaaagac tgataatgcc cgttatcatt 1255081 gtcttcagct tccgaaatag aaatccgcat cccgtgaaga tcatggcggc ccacaacgag 1255141 tctcccagat aagtattgag ggtatcagga agaacactgg agaatgctct ggatccaagc 1255201 cccagcccaa tgatcagtat ggtgaaaact gcatatatcc aacgatttcg cttcattgcg 1255261 aattgatacc ccgtctctgc ttcatctccc tgtattgtaa ggaatatagc ttttatttgt 1255321 ccactaaaaa agcggctgaa tagccgcgta gggtgtttat tttgctttta ggtttacatg 1255381 gtcggctgtc tgatccgtgc ctattacaaa atggagttca tagcggcctg tatcatatac 1255441 ataatcgatt tcatcggtaa acgggacggt taacacccga tttactggtc ctaattgctt 1255501 ctgcagcact tccggcgtaa ctccgcctaa attcagctgc cgttccacac cggttccaaa 1255561 gtagcggatt tctgaaattg tcatgtcttt atgataggaa aatccgtagc ccggctgtcc 1255621 catattccag tgatataaat caaatcgatt gtctcccccg actggtcttt ccggttcccc 1255681 aaacgcagcg tggacatccc cttttgtgct tttgttaatg gtaaggcctt gcgcctgctg 1255741 aggcatttcc cctttatagg cggtgttata gaggtttttg acaagctcag cggctgattg 1255801 attcgtgttt tctgagagtg tgtttgtttg agctgcggcc tttgccggtg ctgaaaagga 1255861 cgcagcccca aagccggtaa aacagcttgt tactgctgct gccgcggtta tagcagacat 1255921 tgtctttttc atgttaatcc ctcctaattg atctaccatt ccgtttcccc gtgtttttgc 1255981 aacgaaacat gtgagtgcgc tttgtatgtt ttattgagtt gttgtaaggg aactgaaata 1256041 ggtaattcgg tatataaagc aagaaagggg aatggagatg gctggcaaga aaacaatcac 1256101 aataaacggc gttgaaatgg aagcgtccga ggaacagacg gtgctgcagc ttttgaataa 1256161 cagctcgatt gaagtgccgc aagtttgcta tcatccaagc ttagggccga ttgagacatg 1256221 tgatacgtgc atcgtcagca tcaatggtga gctgaagagg tcgtgctccg ctgaattaaa 1256281 ggatggggat gtcattgata cgctctcacc tgacgtgaaa aaagcgcagg tcatcgggat 1256341 ggacaagatt ttatataatc atgagcttta ttgtacagtt tgcgattaca acaatggggg 1256401 atgcgaaata cataatacgg tgaaggaaat gaaaatcaat caccaaagca ttccgtttga 1256461 tcacaagcca taccataagg atgaatccca tccgttttat cggtatgatc cagatcaatg 1256521 tatattgtgc ggacgctgtg ttgaggcatg ccaagacgtt caggtaactg aaacgctgac 1256581 cattgactgg gagcggaaac gcccgcgcgt catttgggat aacgacgtgc cgatcaatga 1256641 gtcgtcatgt gtgtcatgcg gccattgttc aacggtctgt ccgtgcaacg cgatgatgga 1256701 aaaaggaatg gaaggggaag ccggatattt aacaggcatc aataacgaaa cgctgcgacc 1256761 gatgatcgag atcacgaaag gcgtagagac aggctacggc tcgattctcg cgatttctga 1256821 tatggaatcg gccatgcgtg atgaacgaat caaaaaaacg aaaaccgtct gcacgtattg 1256881 cggcgtcggc tgcagctttg atgtctggac aaagggcaga gacattctga aagtagagcc 1256941 gcaggaggaa gcgcctgcca acggcatttc tacttgtgtg aaaggcaagt tcggctggga 1257001 tttcgttaac agcgaagaac gcctgacaaa gccgctgatc cgtgaaggcg atcatttccg 1257061 tgaagcagag tgggaggagg cgttattgct gatcgccagc aagttcactg aattaaaaga 1257121 ggcgtttggc ccggattctc tcgcttttat tacatcttct aaatgtacaa atgaagaatc 1257181 ctatcttatg caaaagctgg ccagaggggt cattggcaca aataatgtgg acaactgctc 1257241 tcgctattgc caatctcctg cgactgccgg cctgttccgg acagtcggct atggcggtga 1257301 ttcaggatca attacagata tcgcgcaagc ggaccttgtt ttgattatcg gttcgaacac 1257361 gtctgagtcg catccagtct tatccactcg gattaaacgg gctcataagc tgagagggca 1257421 gaaagtgatc gtcgcggata tcagaaagca cgaaatggca gagcgctcag atttatttgt 1257481 ccagccgcgt gccggatcgg atatcgtctg gctgaatgcg atcgccaaat atttaataga 1257541 aaacggcaag gccgatgaac gatttttgag agaaagagtg aacggacggg atgaatatgt 1257601 aaaaagcctc gcgccgtaca cacttgaata tgctgaggag aaaaccggga ttgatcaaga 1257661 aacccttatc caaatggcag agatgatcgg gcaagctgac agtgtgtgcg cattgtgggc 1257721 gatgggcgtg acacagcata ttggaggaag cgacacgagc acggcgatct ctaatctgct 1257781 gcttgtgaca ggaaactacg gaaaaccggg agcaggttct tacccattgc gcggccataa 1257841 caacgtgcag ggagcaagtg actttgggag tatgcctgac agactaccgg gctatgaaaa 1257901 agtgacggac gaacaagtcc gccaaaaata cgagcgtgtg tggggtgtgc cgctgccgaa 1257961 ggagccgggt atgaccaacc acgaaatgat tgaaaaaatc cattccggac agttgaaagc 1258021 gatgtatgta aaaggtgaag aaatgggcct tgtcgactcc aatatcaatc atgtacacgc 1258081 tgcatatgaa aagcttgatt tctttgtggt gcaggacatt ttcctttcac gtacagcgga 1258141 gtttgctgat gtggttcttc ctgcgagccc gagccttgaa aaagaaggaa cgtttacaaa 1258201 cacagaacgc cggattcagc gtttgtatca ggtatttgaa ccgctgggtg aatcaaagcc 1258261 ggattggcag attattatgg aggttgccaa taagcttggc gccggctggc tctatgagca 1258321 tcctgcagac attatggagg aagcagccaa gctgtcgccg atttatgccg gtgtcaccta 1258381 tgaacgtctt gagggctata attccctgca atggcctgta aacgctgatg gaaaggattc 1258441 gcctttactc tttacagagc gcttcccttt cccagacggc aaggccattc tctaccctgt 1258501 ccagtggaca gagcctaagg aattcggtga ggaatatgat atccatgtca acaatgggcg 1258561 gctcttggag cacttccacg aagggaacct gacttacaaa tcaaaaggga tttcggagaa 1258621 aacaccggaa gtgttcttag aaatttctcc tgagcttgcg gcagaacgag ggattcagga 1258681 cggaaccctc gtcagactca catcgccttt cggaaatgtc aaagtgaagt gcctgattac 1258741 tgatcgagtc aaagggaagg aagtatatct gccaatgaac gattcagggg aagcggcgat 1258801 caacctgtta acaggcagcc atgccgataa ggataccgat acgcctgctt acaaagaaac 1258861 atcggccaag atggaaattt tgaagcacga cggaatcagc ccgctgccta agatcaacca 1258921 ccgcaacggc aatccgcagc cgcaaatcgg tgtgcaggtt cataagaaat gggcgcggaa 1258981 ggattatatt ttccctggtg acgctgtgaa aagggggatg ggccataatg gctaaagcga 1259041 ttaaacgaat ccaaaaaatc gaggtaacag aagaggatca gcgaaagcgt gatttgcggg 1259101 aaattgaaga tgctctaatt gaccacaaag aagcgattct cgaaacattg catatgctgg 1259161 gccatatgaa cgagcgcggg gtcctgccgt tgctccgcgg cctttttggt caaggggata 1259221 aagttcttga tatcctggtg aaaaaggcag atacagagga aacagccaat acgctgaaaa 1259281 atctgcttct tctgtttgga acactcggca tgctggacgt gaagcagctg gagcctctca 1259341 ttttgaaagt gaatgcgggt gtggcaagcg ctgtagagca gaaaaacagt gaagaaaaga 1259401 caggttattt tgatattatc cgctcgctaa aagacccgga aatcaacaaa tcaattacac 1259461 tgctcttttc ctttttaaaa ggaatgggac aagatacaaa ggagctggaa cgcacgacgc 1259521 agcctccgga acaccaaaaa catcatcagg aaccccgaga gaaaagagga atgaataagc 1259581 gagattgacc tcccacccga gcggcttcag ccagctcggg ttttttgatg aaaaggtcta 1259641 atggactagt aaaaaatatt caaatactag gaagaagtaa gattgtgatg aatgagatag 1259701 aaataatcgt tactttctta cctgttaaga aaagggaaaa tctgattata atagaaatcg 1259761 attactttag atgggggaac aatcatgaaa aaagtcttat tactattatt tgtcttgacg 1259821 atcgggttag cgctttctgc gtgcagccaa tcgagcgatg cgtcagagaa ggaaaaaccg 1259881 aaagagaaaa aatcgcaaga agagcttgaa aaggaacttg ataaggaatt gaaaaaaggc 1259941 ggtgagccga agaccaaaaa agatgatcaa atacataaaa taggagaaac atttaaagca 1260001 ggacatacga attttacagt gaataaagtt gatagagtgc aaaaaggtga atatatgaat 1260061 gttggcggag ctgtaaatga ggagacaaaa acaataaaag atgatgagga acggcttatt 1260121 atagaagtta cgatggaaaa tataggggaa gattcaataa gctacaattt tatcgggttt 1260181 gatttaagag ataagaatga tcaatcagtg cggcctgttt tttctataga agagaagggc 1260241 agaatcctta tgggaggaac actagtatcg gggaaaaagg ttacaggtgt actcagttat 1260301 gtcatcccta aaggagaaca gaaacattac acactggtat ataatccgtt tttagctgat 1260361 acaaatagca gtaatacaga agagagagta aaggacgata ttgattactt ggtgaagtta 1260421 gattagatgc taatttacag ttgcacgttt ttcatctgtg gaaaacgtgc attttttata 1260481 gcgaaacttg acttgaaagg atgagtgata aaagtgcaaa ccaaatggct ggaacgggca 1260541 cagcggattc gggcgatcgc ccaagcgggg cttgcttttt ccaaggatgt gtacgacagg 1260601 gagaggtacg aagagctaat gaagcttagc gcggaaatga tggcggatta ctcggagaag 1260661 gacattgaag ttatcactga tttatggcaa ggcgagaagg gctatccaac accgaaagcg 1260721 gatgttcgcg gcgctgtatt cagagagaat cagattttgc ttgtccggga gaagcatgat 1260781 gagctgtggt cgctgccggg cggattttgc gagattggtt tatcgccggc tgaaaacgtt 1260841 gtcaaggaaa tcaaagaaga gtcggggtac gatacagagc cgtctcgatt gctggccgtg 1260901 ctagacagcc ataaacactc tcatccccct cagccttatc actattataa aatcttcatc 1260961 gcatgcagca tgacggacgg gcagggggaa acagggatcg agacgaatca tgccgctttt 1261021 tttccggaag acagactccc gccgctttct cctaaacgaa acacaccctc acagcttagc 1261081 atgctgtttg actttttgcg ccatccggac aagaaaacga tatttgacta aaaaagaaag 1261141 agcctgtggg ctctttcttt tttataatgt aatgtgtttt tcgttggcga gtttcagaag 1261201 ggtcaaaata gaatcggctt gtttatggcc gagtttttgc tttaatttgt tttcttcaac 1261261 taatcggctg ccataaattt tgacggaggc tttgtcgacg acagtatgcc agttttcctg 1261321 tttttttccc tcaacaagcg gtttttcatg tctctcagaa aaagagaaca caaagagtac 1261381 gaatgcaagt gaaagtagga ttccgacaac ttgttttttg taatcagtct gtgctgccac 1261441 gttgttctct ccttcacctt ttaccttcta tttaatcata gaaccaaatt attttacata 1261501 atgggaaagt catttttgga gttagtgcat ttggttgaaa acagagacgt tttttgagcg 1261561 gagcggtgca attgaatcca tattggattt gcgtgcttat gcctaaggtc acgttgtgag 1261621 ccaaaacagc agtgcagaat agaaaaaaat tgaaagatta tggtaagatg aacgaaattc 1261681 gagggggaat atatgatgcc tgcatcgaac atcgtgatcg cctgcctgct gttatcaatt 1261741 taattatttg tggtagtccc tctctttttc gaaagcggga ggtgaagtgg aacattaatt 1261801 gctgaattct ttcaagggga gtgaccgtac atgaatgtgt taaaccgccg gcaagccttg 1261861 cagcgagcgc tgctcaatgg gaaaaacaaa caggatgcgt atcatccgtt tccatggtat 1261921 gaatcgatga gaaaggatgc gcctgtttcc tttgatgaag aaaaccaagt gtggagcgtt 1261981 tttctttatg atgatgtcaa aaaagttgtt ggggataaag agttgttttc cagttgcatg 1262041 ccgcagcaga caagctctat tggaaattcc atcattaaca tggacccgcc gaagcataca 1262101 aaaatccgtt cagtcgtgaa caaagccttt actccgcgcg tgatgaagca atgggaaccg 1262161 agaattcaag aaatcacaga tgaactgatt caaaaatttc aggggcgcag tgagtttgac 1262221 cttgttcacg atttttcata cccgcttccg gttattgtga tatctgagct gctgggagtg 1262281 ccttcagcgc atatggaaca gtttaaagca tggtctgatc ttctggtcag tacaccgaag 1262341 gataaaagtg aagaagctga aaaagccttt ttggaagaac gagataagtg tgaggaagaa 1262401 ctggccgcgt tttttgccgg catcatagaa gaaaagcgaa acaaaccgga acaggatatt 1262461 atttctattt tagtggaagc ggaagaaaca ggcgagaagc tgtccggtga agagctgatt 1262521 ccgttttgca cgctgctgct ggtggccgga aatgaaacca ctacaaacct gatttcaaat 1262581 gcgatgtaca gcatattaga aacgccaggc gtttacgagg aactgcgcag ccatcctgaa 1262641 ctgatgcctc aggcagtgga ggaagccttg cgtttcagag cgccggcccc ggttttgagg 1262701 cgcattgcca agcgggatac ggagatcggg gggcacctga ttaaagaagg tgatatggtt 1262761 ttggcgtttg tggcatcggc aaatcgtgat gaagcaaagt ttgacagacc gcacatgttt 1262821 gatatccgcc gccatcccaa tccgcatatt gcgtttggcc acggcatcca tttttgcctt 1262881 ggggccccgc ttgcccgtct tgaagcaaat atcgcgttaa cgtctttgat ttctgctttt 1262941 cctcatatgg agtgcgtcag tatcactccg attgaaaaca gtgtgatata cggattaaag 1263001 agcttccgtg tgaaaatgta atagataagg agactggaga ttcatgaaaa agtaccatat 1263061 ttcgatgatc aatatcccgg cgtacggaca tgtcaatcct acgcttgctt tagtagagaa 1263121 gctttgtgag aaagggcacc gtgtcacgta cgcgacgact gaggagtttg cgcccgctgt 1263181 tcagcaagcc ggtggagaag cattgatcta tcatacatcc ttgaatattg atcctaagca 1263241 aatcagggag atgatggaaa agaatgacgc gcccctcagc cttttgaaag aatcactcag 1263301 cattctgccg cagcttgagg agttatataa ggatgatcag cctgatctga tcatctatga 1263361 ctttgttgcg ctggctggta aattgtttgc tgaaaagctt aatgttccgg tcattaagct 1263421 ctgttcgtca tatgcccaaa atgaatcctt tcagttagga aatgaagaca tgctgaaaaa 1263481 aataagagaa gcagaggctg aatttaaagc ctacttggag caagagaagt tgccggctgt 1263541 ttcatttgaa cagttagctg tgccggaagc attaaatatt gtctttatgc cgaagtcttt 1263601 tcagattcag catgagacgt tcgatgaccg tttctgtttt gtcggcccct ctctcggaga 1263661 acggaaggaa aaagaaagcc tgttgattga caaggatgat cgcccgctta tgctgatttc 1263721 tttgggtacg gcgtttaacg catggccgga attttacaag atgtgcatca aggcatttcg 1263781 ggattcttca tggcaagtga tcatgtcggt tgggaaaacg attgatccag aaagcttgga 1263841 ggatattcct gctaacttta ccattcgcca aagtgtgccg cagcttgagg tgttagagaa 1263901 agctgatttg ttcatctctc atggcgggat gaacagtacg atggaagcga tgaacgcagg 1263961 tgtgccgctt gtcgtcattc cgcaaatgta tgagcaggag ctcactgcaa atcgggttga 1264021 tgaattaggc cttggcgttt atttgccgaa agaggaagtg actgtttcca gcctgcagga 1264081 agcggttcag gctgtatcca gtgatcaaga gctgctcagc cgcgtcaaga atatgcaaaa 1264141 ggatgtaaaa gaagctggcg gagcggagcg tgcggcagct gagattgaag cgtttatgaa 1264201 aaaatccgct gtcccgcagt aaaaacataa aaaccgaaat caatttgatt tcggttttct 1264261 gtttaaatat tttttttcat cccgcatctc cggcattctc taagaaattt tccgcctttt 1264321 acagagcttt tgaacagtgt gtaatcacag ttgtcgcagc gcccgctgcg ggcatccgga 1264381 tattcattga attcgtaaac aatcgatgta tcgtagcctt ttgtttcata ttcttctttt 1264441 ttggtttcca tgtcgatcct ccgttacaag acgtgtctgc tgtttatctt acagcaagct 1264501 tccggcgtat tcaatggatt ttaggaggtt gggtttatct tgatttctcc cttggtttgc 1264561 gccaaaatag ctttattaag cttatataca taaaaagcct atgcaaagag gagaggaaac 1264621 gggtatggga aaagggttac ttggaaaacg cgtggcaatc ggtggctcac gaaaaacgga 1264681 agaaattagt acaatcattg aaaaacaggg cggaatacct gtcatccggc ctctccaagg 1264741 tacagtttac ttagcagaga agcaggtgga gccggatttg cggacgtttg cggaagaaaa 1264801 agctgactgg gtcattttca cgacaggcat cgggttggag actcttgtcg atatggcaga 1264861 gaaaattgga ctgaaagatg agtttctgca ggccattcgc caagcgaaag cggcatgccg 1264921 gggatacaaa acgctgtctg cgctgaaaaa gcttggaatc acaccggaag cttcggatga 1264981 agacgggaca acaagaggct taatccgttc cttggagcct cacgactttt caggaaaaac 1265041 agtcatggtg cagcttcatg gcgaaaaagc gccggctctc atggcatttc ttgaagaaaa 1265101 aggcgcgtct gtcctgccga ttctgcctta tcagcacatc ccgccggagg aggaaacggt 1265161 ggagcggtta tgccgagagc tgatgaacga tgaggtcgat gccgtttgtt ttacaacggc 1265221 cattcaggtt cgttccctgt ttgattttgc caaggggcga ggttatatca atgaagtgaa 1265281 gaaggtattc gaagaacgcg ccatcgcagc tgctgtcgga aaagtgactg ctgaagcact 1265341 gcgggaagag ggcattacga gactgcttgc gccagagatt gagcggatgg gtgcgatgat 1265401 tgttgagctg gccaagtatt atgaagaaaa ggaataacaa gtacaaaaag ccgcttttcc 1265461 ctcggaaagc ggcttttgtc tgtcattcat tttgcttcag ctgctgatga acggtgaata 1265521 atgatgggta tgtcagcacg cttaagatta cacaagtcag cgcggctgag gccatcgttg 1265581 taaacacgat taagagttga aagcgtactg cctgaatcgg gtccgcgccg gctagaatct 1265641 ggccagtcat catgccggga agctggacaa gacccagtgt tttctggctt tcgagcgtcg 1265701 ggatcatact cattttcatc gctgaggtaa gaatgcgctg tatggattgc ttcggtgtgc 1265761 cgccaagtga caatattaat tgaatttctt ctttgcgaac gccgacttct gagttaagcc 1265821 ggtttagaaa caaacttgag agcaccatcg aatttccgat gaccatcccg ctgatcggaa 1265881 tgacatatcg tgccgtaagc ggaatgatat gaagagacag cagaattccc tgcgtcacaa 1265941 tttctacgat tgctaacgcg gcaaacaccc tccaaaacga accgatagta tttttctttc 1266001 gcttgatgac attttgcgcc gccaccgcga gcattaacag caccatcagc aggataaaaa 1266061 cagggtggtc tccgcgaaaa atcagcgaca aaacataacc gatgataagc agctgcaccg 1266121 cggcccggat ggtggcgatg atcatgtctt tttctacacc ggctttaaag gattttgata 1266181 aaaacaaggc gatcaaaaca aagatcatcg ttaaagagag agaaaggtaa tccattaccg 1266241 agtgcctccc ttcaaaaatt ctttcgctgc ttcatgctgc ggagcggaga aaaatgtgtc 1266301 ggtttcagcg atttcaagca gccggccatc tgccataaac caaatggtat cggctattcg 1266361 ttttgcctgc tccatattat gagtgaccca catgactgtc cattttttct cttgatgctg 1266421 acgtttgatc agttcttcaa tctcaagagc agagaccggg tccaaggccg atgtgatttc 1266481 gtccaacaat agaatggagg aaggatttga gagcgttctg gccagtgaca gtctttgccg 1266541 ctgcccgccc gataagtctc tggcgcttct gtctaacaac tctggcggca gccctgcaag 1266601 cgaagccagc ttttcaggag agtacagctg ggattgatgc agcctttgta caagacttaa 1266661 attgtcacgc actgtcccgt cgagcacggg agccgattga aacgcgaggg ctgccgttcg 1266721 cctcagctca ttgacattcc attctctgac ttcctttccg tatatgttga cttcgccgct 1266781 gtcaggcgtt ctcattaaat tacacataga aaggagggtg cttttgcctg agccggaagg 1266841 gcctaaaacg gctacgattg caccctgttg aatgtctccg gtgacatcct gcagcacatc 1266901 ataggtttgt ccatcttgtt tatagctttt tctgactgat ctgaaggaga tggctggtat 1266961 gttttgtgtt tgatcgtttg cttccattac aataatcacc tttcaatata agtaggctga 1267021 cattatattt aactataacg tgaaacagat tccttttggt agcacaaata aaggagaaca 1267081 ggctttcacc cattctcctg cagatgctac gcagtcagat ttgactgtgc tttctttttc 1267141 ggttttctcg gctgtgaagc gaaggtatgt aacatcatcc ccgctattat aatgaacaaa 1267201 ccggcaaatg ataatagaga tgggaaaacg cctgacagca gaacaatttc accaagcagc 1267261 gcgaaaatca cttcaccgga ttgagtggct tcaacagctg cgagtttttg cggattgtct 1267321 cttaccatat cagtggccca gaaaaataaa accgtcgcaa tgatgcctga gctgacggca 1267381 acgataaagg attgaacggt ttgacttgct gttggaaggc catctgacca ccagccgtaa 1267441 gctgctaata taagccagaa tggaaggctt gccaatgtca ttccaagcac gcgctgaaat 1267501 gtatcaagcc ggcctccgta ttcttcgagc attcttcggt ttcctaacgg ataggcaaaa 1267561 gccgcaatga caaccggcag cacactgaaa agcagcatcc tcccagaaag cgattctgca 1267621 tgctgaagct gaatcagagc cgctccaatc aggatgatca cagaagtgcc aagtgaaacc 1267681 aggggaatct tttggcgaat gagctgcgga ccgcccggca tatcttgttt gacataaaac 1267741 aaaggagata agagcacccc ggctacaatt gtaatttgcc aggttccagc tatgagccac 1267801 cccggaccgt atgcagccgc aaatgtaatc ggtgcgtaaa aaagcacgaa accgacgaag 1267861 ctccatttga tccaataaaa cggctttttc ctcatttcta gtaagagagg cgtgaatgtc 1267921 cctctcatga tgacaatcaa acataaaaat ggcaccataa aaataaagcg cagcgaagag 1267981 ctccaaagcc agctgcctcc tgataactcc atcgctctgt ttaatataaa ggtaacggcg 1268041 aaaaagagtg aagccaatat tccgataacg atagctttca tgatatccct cattctggca 1268101 ttattttttt atactatact attcggtatc atgcagatca atggaatcat gagaaaaaca 1268161 tcatgtttgg cgaaccgcta tatgtggaag acaaaaaagg gaggtgaaat tgatggaaag 1268221 agagacacag acatacttct ttccggatga cggcaggatt ccgaatcacc ctgattttcc 1268281 gctcgtggtg tatcaaaacg cgcttaagga caccggactg gcagagcgga tcgtcacccg 1268341 gcatggctgg tcaaacagct ggtcagggag tgtttttcca taccatcatt atcacagcaa 1268401 tacgcatgaa gtcctgattg cccttaggag agaggctgtg attcagtttg ggggagaaaa 1268461 aggggctgcc atccctttca aatcaggcga cgcagtcgtg attccagccg gagtcggaca 1268521 taaaaagctc agctcaagcc ccgattttac tgtccttggc gcctatcccg gtggcgttca 1268581 gtacgatatg aagacgggga agccgaatga gcgggaggaa gcggtcaaac agattaagca 1268641 ggcggcgttg ccggcgaatg atccgatcac aggaaaaaga gagcctctat tggaaatatg 1268701 ggtaaagtga aggggagaaa ttgctggatt gtcaataact agtgccgcag aaacgatatg 1268761 acatgagctc catataaatt aatttcataa tcgaagcaat tcacgttcaa attttgttca 1268821 aaaagtgtta tcatatagaa ggtaatcgaa ttggagtttt ttgtgtttgc tattttcaga 1268881 gagagtaaag gattttgact tattcaattg tttattttta gataaaaata atactgaata 1268941 tggcaagatg aaaaactggg tagtaaacat ttatttttgt aaatgattgt gcatgaattc 1269001 acaatcctta ttcttatgcc ttaaaagcgt gagacaggga gaggcactac cctttccaaa 1269061 aaaatcagca aactgcttat agtaaaggag aattggatat gccagaaaca atcgatcaaa 1269121 caaatgcgtc tgtcagccaa agccagcaag atcttattga tcagctatta aagccagaag 1269181 ttcaagaatc attgactgtt ttagttgacc agcttccgaa gctgactgag ttagtgaata 1269241 ttttaacgaa gtcttatgat ttcgctcagt ctgtagcgac tgacgaagtg ttaaagagcg 1269301 acacagtcgg tgcgatcact gaaattctcg agcctgtaaa agaaacagcg aaagaagtag 1269361 ctgcgactgc gatcgaagca aaagaccgcg cggaagcaag caacgaaaca attggacttt 1269421 tcggccttct tcgcatgctg aaagatcctc aagctcaaaa gctgttccgt tttgctaaca 1269481 gctaccttga agtcatgaac gaacgcgaaa accaaaaata atctcagatt caaattgata 1269541 taaaggacgg aggatatacg atgtcaaaac atattgtcat tctaggcgct ggttatggcg 1269601 gagttctttc tgctctaaca gttcgcaaac attacacaaa agaacaagca cgcgtgacag 1269661 tggtaaacaa atacccaact caccaaatca ttacggaatt acaccgcctt gctgcaggca 1269721 acgtgtctga aaaagcggtt gcaatgccat tagaaaaact tttcaaaggc aaagacattg 1269781 atcttaaaat tgcggaagta agctctttct ctgttgataa aaaagaagtt gcgcttgctg 1269841 acggttctac attaacttac gatgcgcttg ttgtaggtct tggttctgta acggcttact 1269901 tcggcatccc aggtcttgaa gaaaacagca tggtattgaa atctgctgcc gatgcgaaca 1269961 aagtcttcca acatgttgaa gatcgtgtgc gcgagtactc taaaacgaaa aacgaagcag 1270021 atgcaacaat ccttatcggc ggaggcggct taacaggtgt tgagcttgtt ggtgagcttg 1270081 ctgacatcat gccgaacctt gcgaaaaaat acggcgtaga ccataaagaa atcaaattga 1270141 aacttgttga agcaggtccg aagatccttc ctgttcttcc ggatgatctt atcgagcgtg 1270201 cgactgcaag ccttgaaaaa cgcggcgttg agttcttaac aggtcttcct gttacaaatg 1270261 tagaaggaaa cgtaatcgat ctgaaagacg gatctaaagt tgttgccaac acatttgttt 1270321 ggactggcgg cgtacaaggt aacccattag tcggtgaatc aggcctagaa gtgaaccgcg 1270381 gacgcgcgac tgtaaatgac ttcctgcaat ctacatctca tgaagatgta ttcgttgctg 1270441 gagacagcgc agtttacttc ggtccagacg gccgtccata cccgccaact gcacaaatcg 1270501 catggcaaat gggtgagctg atcggttaca acctattcgc ttacctagaa ggcaaaacgc 1270561 ttgaaacatt caagccagta aactctggta cacttgcaag ccttggacgc aaagacgcgg 1270621 ttgccatcat tggtgctaat tctacaccgc ttaaaggtct tcctgcttcc ttgatgaaag 1270681 aagcaagtaa tgtacgatat ttgacacata ttaaaggact tttcagcctg gcttactaat 1270741 ccttttaatg aatctggcat tgccaaaagc attcctttcc gagtgctttc tggcaatgtc 1270801 tttttttatg tttatgacag cgttaacatt tcattttcaa aaaagagatt gatcccaaag 1270861 gaatataaag gtaaaataaa aacaaatcaa aatgttaacg ttaacatttt gaaatagaat 1270921 gaaagacggt gaggacatgg aacccttcat gggcaaaaac tttttattga aaaatgaaac 1270981 cgctgtcagc ctctatcaca attatgcgaa agacatgcca attattgatt accactgcca 1271041 cttaagtccg aaagaaatct atgaaaataa gacatttcaa aacatcacgg aagcctggct 1271101 gtatggtgac cattataaat ggcgcatcat gagagccaat ggaattgagg agacatacat 1271161 taccggagat gcgcctgatg aggagaaatt tatggcttgg gcgaaaaccg tgccgatggc 1271221 gattggcaac ccgctctaca actggactca cttagaattg cagcgttttt ttggcattta 1271281 cgagatttta aacgagaagt ccgggtcggc tatatggaaa cagacaaata aactgctcaa 1271341 aggggaaggc ttcggggcaa gggatttaat cgtgaaatca aatgtaaagg tcgtgtgcac 1271401 cacagatgac cctgttgatt ctcttgaata ccatttattg ttaaaagaag acaaagactt 1271461 tcctgtcagt gtgctgcctg gatttcggcc ggataaagga cttgagatca atcgtgaagg 1271521 ctttcctgag tgggtgcagg cgcttgaaga tgccgctgcc atatcgatta caacctatga 1271581 tgagttttta aaggcgttgg aaaaacgagt gcgattcttc cactcagccg gcggcagagt 1271641 ttctgatcac gcgatagata caatggtatt tgccgaaaca acaaaagaag aagctggacg 1271701 gattttttct gacagattac aaggaacaga ggtttcttgt gaagatgaga agaaatttaa 1271761 gacatatacg cttcagtttc tttgcggttt gtatgcggag ctcgattggg cgatgcagtt 1271821 tcatatcaac gctttaagaa acacgaatac aaaaatgatg aaaaggctcg gacctgatac 1271881 agggtatgat tcaatgaacg atgaagaaat tgctaagcct ttatacaagc tgctgaactc 1271941 agttgagatg aagaaccagc tgccgaaaac gattttatat tcactgaatc caaatgataa 1272001 ctatgtcatc gccagcatga tcaacagttt tcaggacggt attaccccgg gaaaaataca 1272061 attcggcaca gcctggtggt ttaacgatac taaagacgga atgctcgacc aaatgaaagc 1272121 gttatcaaat gttggccttt tcagccgttt tatcggcatg ctcaccgatt ccagaagctt 1272181 tctttcgtat acgcgccacg aatatttcag gcggatcgtc tgcaatttga ttggagaatg 1272241 ggtggaaaac ggcgaagtgc cgcgcgatat ggagcttctg ggaagcatcg ttcaggggat 1272301 ttgctatgac aatgcgaaac actactttca atttcaagaa gagaaagcaa acgtgtaaca 1272361 aagtgtccgc tcagtatcgc tgagcggatc actatccgaa aattcttaag acacagaggt 1272421 ggaacatgcg aactgaactg gcaaataagg ttgtgtcggt cgaaacggaa aaaaggcttt 1272481 cattgaaaga gaaaatgtcc tatggctttg gtgattttgg caacggtttt atgtttgatc 1272541 tcggccagat ttatttattg aagtatttca ctgatgtagc gggaatcccc gctgcgatgg 1272601 ccggcggcat ttttttagtc agtaagctgt ttgcagcgat aacagatcca attgtcggct 1272661 catcaatcga ttatcgcaaa aacatcggca aacgggggaa attcaggcct tatctattaa 1272721 tcggcagcat cgtgcttgcg gtgcttactg ttcttatttt tctgtctccc aatgtatcaa 1272781 cgaccggaaa actgatatat gcatatgcat cctatatgat ttggggcatc ggctattcgt 1272841 ttgtgaatat tccgtacggc tcattagggg cagcgatgac tcaaaattct gaggaccgga 1272901 cctccatttc gacgttccgc caaatcggat cacttggcgc cttgtttatc acaagtgtgg 1272961 ccgtgatgcc gctgctcgtc aagtttgata atccgaaggt cggctacccg gtggtcatgg 1273021 gcttgttcgc cgcgctcggt gtgttttggt tttatatttg ctaccgcaac tgcaaagagc 1273081 gcattatcat atcggaagca cccaaagaaa aattaacact ctcatctgtc gtcaaaacat 1273141 ttattacaaa taaaccgctg ttaacccttg tcctgatgac gattttttca atttccgcat 1273201 acaacattaa atccgccatg ctcgtctatt tcgcacaata taacttgggc aatgttgaat 1273261 taatggctta tatgaacttc atcattattg gttcttcctt tttgggcgtc gtattccttc 1273321 caaagctcgt caagatgttt ggaaagaaac gaacggcaat gatcggcttt ggcatcagtg 1273381 tggccgcgga tctgatcaac tttatgcttc catctaacgt ttatgtgttt acaattctcg 1273441 ccagtatcgc ctttatcgga atcagtatcc caaatggcat cacgtgggct cttgtctccg 1273501 atattatcga ctatggcgaa tggaaatccg gtgaacggaa ggaagcaacg acatattcac 1273561 ttttcaattt ctcaagaaag cttgctcaat ctttgtctgg ctttctctcg gggatcggtt 1273621 tggggattat cggctatgtg ccgaatgcag tccagacagc acaggcgctg attggcatca 1273681 aagcgctgct tcttctgtat ccggccattg ctttggcatt agcgatgttc attatcggct 1273741 ttctttataa actcacagac cagcagcatg ctcagatcgt tcaggatctt catcaaaaga 1273801 gctgacaata taatataaag aatatttaaa ataatttgta aataaaatgt gtttgtaggg 1273861 gtttcgcttg gagagtgccc aaaaaactga aaaggaagga ggcacttgct tgaaaacgat 1273921 aacaattgca gctgaagaag caaaggaact cgtttggcaa aagctggacg gtgccggttt 1273981 gaatgaacga gatgctgaaa aagtggcaga tgttctcgtg cacgctgatt tgcgcaatgt 1274041 acattcgcat ggcgtgctgc acacagaaca ctatgtgaac aggcttttag cgggagggat 1274101 caatcctggg gcacagcctg tttttaaaga gacggggcct gtgaccgggg tgcttgacgg 1274161 agacgatggt ttcggtcatg tgaattgcga catggcgatg gaccatgcaa ttgacatggc 1274221 gaagaaaaaa ggagtcggca tggtcacggc cgtaaacagc agccattgcg gagcgctaag 1274281 ctattttgtg caaaaagcgg ctgacgaaaa gctgatcgga atggcaatga cgcatacaga 1274341 cagtatcgtt gtcccatttg gggggaggac tcctatttta gggacaaatc cgattgctta 1274401 cggagttccg gctaagcata aaaaaccgtt tatcctagat atggcgacat ccaaagtggc 1274461 ttttgggaag attctgcagg cccgtgaaga gggcaaagaa attcctgaag gatggggagt 1274521 cgatgaaaac ggagaagcag taactgatcc tgacaaggtc gtctcacttt caacattcgg 1274581 gggcccgaaa ggctatggac tatcgattgt agtggatgtg ttttccggat tgctggcggg 1274641 cgcggctttt ggccctcata ttgccaaaat gtacaacggc cttgatcaaa aaagaaagct 1274701 ggggcattac gtttgcgcga tcaatccatc cttttttact gactgggata cgtttttaga 1274761 gcagatggat gccatgattg atgaactgca gcaatcaccg ccggctgttg gattcgaaag 1274821 agtgtatgtg cccggcgaga tcgagcagct gcatgaagaa agaaataaga aaaacggaat 1274881 ttctatcgcc cggagcgtgt atgaattctt aaaaagcagg tgagtaaaat gaaagcggtt 1274941 caagtgcgaa aagcgtatga tctggtgaca gcggaggtga agaagccagt tctttcaaag 1275001 gatgatgaag tgctcgtgaa agtcaagcga gtcggcattt gcggttcaga catgcacatt 1275061 tatcatggaa cgaatccgct cgctaccctc ccgagagtca tcggacacga ggtaacggga 1275121 caagtggagg cagttggtgc gaatgtacag agcctaaaac ccggtgatca tgtggtgatt 1275181 gagccgattt cttattgcgg atcgtgctat gcctgccgca aagggcggcc gaatgtttgc 1275241 gccaagcttt ctgtatttgg cgtacatgag gacggaggca tgcgggaata tattgtgctt 1275301 ccggaaagac agcttcacgc ggtctcaaag gacttgcctt gggaggaagc agtcatggcc 1275361 gagccttata cgataggcgc ccaggcagtg tggagaggcc aggtggaaaa aggtgatacc 1275421 gtcctgatcc agggagcggg gcccatcggg atctgtgtgt taaaaatggc aaaactggcg 1275481 ggcgctgctg tcatgatgac tgacttgaac aacgagcggc tggcatttgc gaaagaaaac 1275541 ggcgccgatg ctgttgtaaa tgtccaagca gaacatgttg ccgagcgggt ccttgaatgg 1275601 actgggaatg aaggagcaaa cgtggtcatt gatgctgttt gcctgccgga gacttttgca 1275661 ctttcaattg aggctgtgtc accggcggga catgtggttg tgcttggatt tgatgaaaga 1275721 gcggctcaga tttctcagct gccaattaca aaaaaagaag tcacgataac cggatcccga 1275781 ttgcagacca atcagtttcc aaaagtggta gagcttttga atggaggccg gttaatgcat 1275841 aacgggctgg tgacccatac attttcagtt gatgacgttc atcatgcatt tcagtttatt 1275901 aaggagcatc cagatcaggt gcggaaagcc gtcatcacgt ttgattaaat gactgaatcc 1275961 ggaggtgcga gcatgaatat gacattccga tggtatggac gaggcaacga tacagtcaca 1276021 cttgaatacg tgaagcaaat tcccggtgtc aaaggcatcg tttgggctct ccatcaaaag 1276081 cccgtcggcg acgtgtggga aaaagaagaa atcagagccg aaactgaata tattcaatcc 1276141 tatggttttc atgctgaagt tgtagaaagc gtgaatgttc acgaagcgat taaacttggg 1276201 aacgaagaac gcggccggta tattgaaaac tacaagcaaa cgatccgcaa ccttgccgga 1276261 tttggcgtga aagtgatctg ctataatttt atgccggttt ttgattggac acgcacggac 1276321 atgttccggc cgctagaaga tggatcgacc gctctgtttt ttgaaaaggc caaggtggaa 1276381 agccttgatc ctcaagagct gattcggacg gtggaggaag catccgacat gacactgccg 1276441 gggtgggagc ccgaaaaatt ggctcggatc aaagagcttt ttgctgccta cagaacggtc 1276501 gatgaagaaa agctatggga caatttatca ttctttttgc aggaaattct tcctgttgct 1276561 gaggcctatg gtgttcaaat ggccattcat ccggatgacc cgccgtggcc gattttcgga 1276621 ctgccgcgca ttatcacagg agaggcaagc tataagaaac tgcgggcgat atcagattca 1276681 ccgtctaatt gtatcaccct ttgtacaggt tcaatgggag ccaatcccgc taacgacatg 1276741 gtggagatcg ctaaaacgta tgccggcatc gctccatttt cacatattcg caatgtgaaa 1276801 atttatgaga atggcgattt tattgaaaca tctcatttaa caaaggatgg ttcgatcaac 1276861 attcaaggcg tgatggaaga actgcataag caggattacg aaggatatgt cagaccggat 1276921 catgggcgcc atctttgggg cgagcaatgc cgcccgggat atggcttata cgatcgggca 1276981 cttggcatca tgtatttgaa cgggctgtgg gacgcttatg aagcaatggc aaaaaaagag 1277041 gtgggcatat gatcccgctg catgagaacc tggctggtaa aacggctgtc atcactggcg 1277101 gcagcggcgt gctttgctct gcgatggccc gggagctagc ccgtcatggc atgaaggtgg 1277161 cgattttgaa tcggacggct gaaaaaggcc aagcggtcgt gaaggagata acggcggctg 1277221 gcggcacagc gtgcgctgtt gctgcggatg tgctggacag gatgtcactg gagcgggcaa 1277281 aggaagacat ccttggccaa tttggcgctg ttgatctgtt aattaacggg gctggcggca 1277341 atcatcctga cgcgataacc gatgtggaga catatgaaga agcgggagaa ggccaatcct 1277401 tttttgatat ggatgagagg ggctttctaa ctgtattctc caccaacttc accggtgcgt 1277461 ttctggcctc gcaagtgttt ggtaaagaac tgctgaaggc ggattcaccc gcgatcatca 1277521 acctttcttc catgagtgct tattcaccta tgacgaaggt tccggcatac agtgctgcga 1277581 aagcatccat caataatttt acgatgtgga tggctgttca ttttgccgaa accgggctgc 1277641 gggtcaatgc gattgcccca ggcttctttc tgacaaaaca aaatcatgat ctgctgatca 1277701 accaagacgg aacgttcacc agccgatctc acaaaattat tgcgggaaca ccgatgaagc 1277761 gcttcggaaa accggaggat ttgctcggta cgctcctttg gctggcggat gaatcctatt 1277821 ccggttttgt cactgggatc accgttcctg tcgatggagg atttatggct tattcaggtg 1277881 tgtaacgaaa gcggtgcaac agaaactgaa ccaacatagg ggtgaggttg agatgttttc 1277941 aaaagataag cttcccgtta tccttttttt gttcctggca ggggtgatta attacctgga 1278001 tcgctcggcg ctttccattg cagctccttt tattcaggat gatctcacat tgtctgccac 1278061 acaaatgggc ttgattttca gcagtttttc gataggttat gccattttta attttcttgg 1278121 gggcgtggca tccgaccgct atggggcaaa gctgaccttg tttgtcgcga tggttgtttg 1278181 gtcgctgttt agcggagcag tcgccctcgc ttttggcttt gtcagcctgc tgattatacg 1278241 cattctcttc ggaatgggag aaggcccgct ttcggcgacc atcaacaaga tggtgaacaa 1278301 ctggttcccg ccgacccagc gggcgtccgt tatcggtgta accaacagcg gcacgcccct 1278361 cgggggagcc atttccggcc cgatagtcgg catgatcgca gtggcgttca gctggaaggt 1278421 atccttcgtt ctcattatga ttattggatt gatatgggca gtgctctggt tcaagtttgt 1278481 caaagaaaag ccgcaagaga cgatcaagga agcaccggca ataaaagcag aaacgtctcc 1278541 cggagaaaaa attccgctca ccttttacct gaagcaaaaa acagtcctgt tcacggcgtt 1278601 cgcttttttc gcttacaact acatcctctt cttctttttg acatggtttc cgagctatct 1278661 tgtcgacgag cggggattaa gtgttgaatc gatgagtgtc atcacggtca taccgtggat 1278721 tttaggattt atcgggctgg ctgcgggggg atttgtttct gactatgtgt acaaaaaaac 1278781 ggcccgaaaa ggtgtgctgt tctcgcgcaa ggttgtgctt gtcacgtgtt tgttttcatc 1278841 agctgtcctg attggttttg ccgggcttgt ggcaacgact gcgggggctg tcactcttgt 1278901 cgctctgtca gtgttctttc tttatttgac cggtgctatc tattgggctg tcattcaaga 1278961 tgtggttgat caaaacaatg tcggttctgt tggcggcttc atgcatttcc tcgccaacac 1279021 ggcaggaatt atcggcccgg ctttaaccgg atttattgtt gaccaaacag gcacgttttc 1279081 tggagcattt ttgcttgccg gtgggctggc tgtcttcgct tcacttgctg tgattcgttt 1279141 tgtccgtcca atcattggta agccagcggg aacagaagct gagaatcctg tgtcttatta 1279201 atctggaaat atagtgggag aggcggtatg tttgatgata caatatacag taaataatcg 1279261 cagccggtat gataaggaag ggaattagat ggtaaccata aaagatatcg caaaactcgc 1279321 aaacgtatcc cacactactg tttccagagc actcaacaac agcccttaca tcaaagaaca 1279381 tacgaagaaa aaaatattag agctagcaga gcagctcaac tatacaccaa atgtaaatgc 1279441 gaaaagtctg gcgatgcaaa agtcgcatac gatcgggcta ttctttacaa gcattacaaa 1279501 cggaacctca cacagcttct ttgcagacac tatcaaaggc gtcaatcaag ccataagtga 1279561 ggattacaat ctgtatgtgc gcggcattga tgatctgaaa aactatgact ccgttacacc 1279621 gatgagatat gacggcatca ttttaatgag ccaaagtgac attgataatt cttttattta 1279681 ccatattcgc gaaaaaaaca ttccgcttgt cgtgctgaat cgtgatattg atgatcgtac 1279741 catcacgaat attttgtcca atgacaagga aggctctcaa gaagctgtag aatacttcat 1279801 tcagtccgga catcaagaca tcgccatcat cgaggggatc gaaggcttta aatcctccca 1279861 gcagcgaaag gaagggtact tatccgcact gattcaacat catattccga tcaagcatga 1279921 atacagtgtc aaaggacagt acgatatgga aagcggcttt caagcgatgg agcggctgct 1279981 ggcactgccg aatcctccaa ccgctgtttt ttgttcgaat gatgacatgg caatcggagc 1280041 gatgaatgcg atattcgcaa agggcctgcg cgttcctgat gatatttcgg tgatcgggtt 1280101 tgatgatatt gggttttcac agtacatcac gccaaggctt tcaacagtaa agcgcccagt 1280161 ggagaaaata agcgtgctcg gtgcgcaaaa actcttgtcg ctgatcagcg agcccgaaac 1280221 aaaagcagaa aaaatcttgg aaaacacaga atttatggtg cgtgattcag tcagacgatt 1280281 gacgacgtga tgtcccgttt ttcagcgggc attctttata cagaaaaatg ttaacgtgtg 1280341 cataaagtga gagggaggca ataagggtgc agaagctgaa taaaaatgtg tacgatcact 1280401 atactcagta tccagaaaaa attctccaat tcggagaagg aaactttctt cggggattta 1280461 tcgattggca gattgatcaa ttgaatcaac acactgattt taatgggagc gtggcagttg 1280521 tccagccaag aggctcagaa aaaatcaaac gattaaatga gcaagatgga ttatatacac 1280581 tttttttaca aggaatgaaa gacggagaag cggtaaacga gcatatgatt atcaactcaa 1280641 tcagccgggg aattgacctg ttttctgatt atgaagcata caaagaattg gcatcaagcg 1280701 aaaggcttcg gtttattatc tccaacacca ctgaggctgg gattgtatgt gatgaaaaag 1280761 atcgtttaga ggataggccg caaaaaacat tccctgggaa attaactgca tttctttact 1280821 ttcgctatca ggcttttaaa ggagatcaga caaaagggtg tgtcctgatc ccatgtgaac 1280881 tgatcgagaa taacggtgaa aagctgaggg aaacggttct tcattatgca catctgtgga 1280941 agctggagga aggatttaca cagtggattc atgaggccaa tacattttgt aatagtttag 1281001 tagaccggat tgttccgggt tttcccgtcg acagcattga tgagatcacg gcagatcttg 1281061 gctatcagga tgatttgata gttgtgggag agcaatatta tttgtgggtt atcgaggggc 1281121 ctgattggat tggaaaagaa cttccctttg cggctgcagg gctgcataca aagatcgtca 1281181 gcgacctcac cccataccgg actaaaaaag taagaatttt aaatggcgct catacagcaa 1281241 tgacgccagt ggctttatta tacggcttga agactgttag ggatgcagtc gagcatccgg 1281301 aagtggggcg atttataaga gagctgattg atgacgaaat tcttcctgtt ttaaaaatgg 1281361 aaggtctttc tcagtatgct gacgatgtgc tgaaccgttt taaaaacccg tatattaagc 1281421 attacctgga aagcattgca ttgaacgcca tttccaaatt caaaacgaga aacctgccga 1281481 ctcttaagga atatgctgaa caaaagggac agcttcctga acgcttggtg ttttctttca 1281541 gcgctcttct gtatttttat catgataacg agacattgca ggatgatccg gcagttcttc 1281601 aatttttcaa agaggtttgg tgtcaggagg atggcgacat gcttcggatt gcatcaagag 1281661 tgttaggcga acagcggctg tggggggcag atctcaatga gataccgaag ctgactgata 1281721 gagtcgctgt ttacttgaat catattcatg agctgggcat gcagagggct cttgaacaat 1281781 actgcataca agggggagag gtacgttgaa gtcgtttata aagattcata agcaagataa 1281841 tgtccttctt gctctgcggg atattcaaaa gggagagagg ctgcatgctt acggcgtgtc 1281901 gattgaagta aaggatgata taaaaagagg ccataagatt gcattgcagt ctatcaaaga 1281961 aaacgacagc atcgtcaagt acgggtttcc aatcggtcat gcatcacaag atatctcgat 1282021 cggagagcat attcatgtcc ataatacgaa aacaaacctg tctgatatcc aattatacag 1282081 ctatacaccg agatttgatg aaaatccgta ttctaatgag aaccggacgt ttaaaggttt 1282141 tagaagagaa aacggagatg cgggtgtacg gaatgaattg tggattgtcc caactgtcgg 1282201 ctgtgtcaat ggaatagcag aaaaaatgct gcagcgtttt gtcagagaaa caggggatat 1282261 cgctccattt gataacgtac tggtgttaaa gcatcaatac ggatgctcgc agcttggcga 1282321 cgatcatgaa aatacgaagc agatcctgct gaatgccatt cgccatccaa atgccggcgg 1282381 cgtcttggtg ttagggcttg gctgtgaaaa caatgagctg gcaagaatga aggaagcact 1282441 gcaagatgtg aacttgaagc gggtgaagtt tctggaatcc cagtcggtga ccgacgaaat 1282501 ggaggcaggc gttgctttgc tgaaggaaat tcatgaagcg gccaaaggag ataagagaga 1282561 agacattccg ctgtctgaac tgaagatcgg gctgaaatgc ggaggttcgg acggtttttc 1282621 cggcataacc gcaaacccgc tgcttggacg tttttcagat tatctcattg cacagggagg 1282681 gagtactgtg ctgacggaag taccggaaat gttcggcgca gaaaccatcc tgatgcagcg 1282741 ggctgccaat gaagaagtgt ttcataagat agtcgattta atcaatgatt tcaaacaata 1282801 ctttattaaa catgatcagc cggtgtacga aaatccttca ccgggcaaca aagcgggcgg 1282861 catttctaca cttgaggata aatcgctggg ctgtacgcaa aaagcgggga tttctcctgt 1282921 cacggatgtc ttgaaatacg gtgaagtact caagacaaaa gggctgactc ttttgagcgc 1282981 accgggcaat gatttgatcg cctcctccgc attggcggct gccggctgcc aaattgtcct 1283041 ctttacaacg ggaagaggca cgccgtttgg cacctttgtc ccgacggtga aagtagcgac 1283101 aaacaccgag ctgtatgagg cgaagccgca ttggattgat tttaacgcag gccttttagc 1283161 agaggatgat gttcatgagg aatatgtgct gcgtgagttt atccactata tgattgaggt 1283221 ggcaagcggc cagcttgtga accatgaaaa aaatgatttc aaagaactcg ccatttttaa 1283281 atcgggtgtg acgttataat aagaaaaggc tatccttcaa gcggatagcc ttcttcatta 1283341 aatcaatttt aaaccgctga ctaaaataat ggaagccata ataaattgca gtggacgcgg 1283401 ggagaatcga ggcgaaagat ggctcccgat cagtacgccg ggaattgaac cgaggagcag 1283461 attagctgcc agcatgtaat ccacgcttcc gaagcttgcg ttcaaaatgc ctgctgccgt 1283521 aacaagaaga aaagcatgcg cgatatcggt tccgacaatc tgtgacgctt tcatgttaaa 1283581 taagtaaatc atggcgattg caaataatga gccggacccg attgatgtta atccgacgat 1283641 aaacccaaac acaacaccaa taagaattgt cagcgccctc ttattttcaa gcggcatcag 1283701 ctgccagcgg ttggggcgaa gttttctatc caaaaacaaa cgaacgatga ttgaaatggc 1283761 aaccagcgtt aacacatatc ctagagcgtg cttaataatt tcttcctgat gctggtgaaa 1283821 ggcggggaac aaatgcaata tgccaatggc tagcgaagca ctcggaatac tgccgatggc 1283881 taagtatttt accaatttaa agttaatcgt tttctgccgc caatgggagg caacgccaaa 1283941 cagctttgtg atcgagttat atacaagatc cgtaccgacc gcgatggaag gattaattcc 1284001 aagcacaatt aaaaggggag ttaataaggc cgctccaccc actcccgtca atccgactaa 1284061 ggctccgaca aacaaaccca tcaatatgat gcttacactc atgataaagg cctcctgaaa 1284121 acccgactag aattcacccg aatcttattc gcgttggtca agtattaatt gtaagtgctc 1284181 catcggctgc tgaaaaaccc gagctctatc cgctccctga tggtatcatt caattgacaa 1284241 caccttatac atcaggagaa cacgtctttc aggtgcaacg agcacttgcg gctctgtatt 1284301 tttaccctga taaaggcgct gttaacaacg gaattgacgg cgtttacgga ccgaaaacag 1284361 ctgacgcagt tgcccgtttt cagtctgtta acggtctaac tgctgacggt atctacgggc 1284421 ctgcgacgaa agagaagatc gcagcgcaat taagctgatc aaagaccata aaaatcccgg 1284481 agccgctccg ggatttattt tttcttcttc aactttttta taattccagc actgcgctcc 1284541 ctcacccgaa gcgagtaccc ggaaagccca aaccttccgt aatcaacaaa cttcacacgc 1284601 ctcaccaatt ttttcactgt atcacctgac attatcctct gtttgtattt attatatgtc 1284661 accctttaag aaaaggaata aggacaagag ctgttttccc ttgtcctttt agtgtgatca 1284721 tgcttttttt cgtttatact cgtcaatcag ccgttcgttt tctttgaaga ttcttgctgt 1284781 atgcggactg acttgatagc ttgcgacact ggtggttgaa cgttttttca ggattttaaa 1284841 cggcttcgcc gctctgggct cgcatctgtt ttgaaacgca cgttccatta tccttcacct 1284901 tcctcctcaa ttggcagcac caaatcatat atgctcgtta atgacgtaaa tagcaaataa 1284961 tcaaattccg tgacaatgct gtcagacgtc agcttgatga catagttctg tgtctcgatg 1285021 gtaaaaggga tgagaaccac ttttccgtat tggtcgtaat aaacatcctt tcgatcgagc 1285081 cgtgtttgta catctgccgg atcatccata tgctcggtta accggtcttt atcagcctgt 1285141 gtcgaatagt ggcaaagaga agccgttaag ttcattttat cagcataggt tttcagcagc 1285201 ttatcaatac cttcagcata agcatctata cttccataat aaacatggat cggttcgttt 1285261 ttcaataggt attggtatgt tttcagccga ttgagataca tgtggagcat ttcgttgttt 1285321 tcttcaagaa tttctcttgt gtctgtttca agctcgctgc cggccagttt tttgacatat 1285381 gcacttaaga agataaaagc atcaatcaaa gcaaaactga ctgcgacaat gagataccgt 1285441 tcccagtggg taaataggga agtgggctca tatgtccagt ataccatagc gcccagaaca 1285501 aacagcaaat accaagtttt ccgaatggcg gacatttttt ctttgacctt cgcttcgaaa 1285561 cgccacgtgg catacacgta taaccccagt ccggccacga tgcaccagac catgatctga 1285621 aagaataaaa ccatattcga atccctcaca tctgaaatag gttctgctta ttgtattcga 1285681 gagatccgga tggttttcct gttccatcaa aaaaaccgct cctttgacag aagcggtgtg 1285741 acattaaaat atcatattta aaataaagta ggcgatggca ccaagtgtcg ctgaaatcgg 1285801 aagcgtgatg acccatgtaa tgagcattcg cttggccgta ccccagttta cgccttttac 1285861 gcggtgggac gcaccgacgc caagaattga tgaagaaatg acgtgggttg tactgaccgg 1285921 caaatgaata aacgtggcgc cgaaaataat ggctgctccg gttaagtcag cggaaacacc 1285981 gtttaccgga cggattttca tgatctttcc gccaacggtt ttgatgattt tccagccgcc 1286041 gattgatgtt ccgagaccca tggctgtcgc gcaggcgaat tgcacccagg taggaatatc 1286101 attagcagaa gtatgtaaat tcgctgtgat gagagccatt gtgataattc ccattgcttt 1286161 ttgcgcatcg tttgttccgt gtgtatacga ttgcagggca gctgttacaa tctgcactct 1286221 gcggaattgc ttattcgttt tcgccaagtt gctgtctttg aaaatcagct taacgatgct 1286281 ataaagaata aaaccaagga caaaggcaat aattggtgat agaatcagtg cttcaatgat 1286341 tttaatgaag cccttatagt ttaacgctgc aaatccggct gccgcaatgg ctgcaccggc 1286401 aatagcgccg atgatggcat gggatgagct gcttgggata ccgtagtacc atgtgataag 1286461 gttccaggca attgcagcga gtagcgcagc caaaatgaca acagagccat tttccagcgt 1286521 ataaggatct acgatgtctt tcgtaatggt tttggcaaca cctgtaaacg tcattgctcc 1286581 gacaaagttc atcacagcag ccaatataat ggcatggcgc ggttttaacg cttttgttga 1286641 taccgaagtc gcaattgcgt ttgccgtatc atgaaacccg ttgatgaaat caaacgccag 1286701 agcacaaatg actattagta tcgttaatat taatagaata tccattttta cccctcgtta 1286761 cgcgtttttc ataatgatgg tttcaagatt attggcaaca ctttgacaag agtcggcgat 1286821 ttcttcaagc gtttcgtata tttcacgata ttgaatgact ttgattggat ctgtttcatt 1286881 tccgaaaaga ttctttaatg attttctgtg caagttgtca caactgtgct catactcttt 1286941 aattttgatt gcgtgaggct gaatatcctt taagcgattt tctgccagca gctcgatcgt 1287001 aatcaaaatc tctttcgcac attctctgat atatccgctg aatttatcaa tatgctcgtc 1287061 tgatgaagta attgagaaaa tctccatcat ggcagagaaa tgttcgattc cgtcaagcac 1287121 atcatccaag ctgtttgtca gctgaaggat atcttcgcgc tcaataggag tgatgaacgc 1287181 tttgttaagc tctttaatca tgacatgaac atgattgtca ccttttgttt catattcctt 1287241 taacgtatct gcaaattctt taagagtcgt ttggttagtg accttaaaat tcacaaaata 1287301 ttctgcagtt tcgtctatgt tctttgcaat ttctgttaaa aggagtgaga acttatcttt 1287361 ttttcttctt atcattaaaa accctccata gtttgaatga acaatgcaca catcaaatta 1287421 ttatatagcc ttttgtcgaa aaaaaacagg taaagtcgaa aaaaacgtat cttgactttt 1287481 ttgataaatc gtgtctcctt attttgacct acttcgcttt aaaaaaacga cccaagtttg 1287541 caaaaacttt ctgcttaacg taaaaagtat atcaaaagtt gtgtttttcc tgtcaacttt 1287601 tatcttctgt ttcaccaaaa aacggttccc taaacaaggg aaccgtttta tcagcttgct 1287661 tttcgttttt tcatcccgta ataaacaggc agtccggcaa ggccgatgag gatggataat 1287721 ccgcagctca ttgtatctgt aatgagtgtg ctgcctaaca caaagaagga gcccgcgatt 1287781 gccagaattg gcataaatgg ataaagcgga acactgtagg cgcgcttttc tccctttgct 1287841 cgcttgcgga gaataaacac tgcaaaaaag gccatcacat aaaaaatgta gatcatgaaa 1287901 atggagattt ctgagagctt atcagggttg ctgatcagca tcataatcaa agccaaagca 1287961 atttgaaaag aaatcgcaat ccatggtgtg cggaacgacg ggtgtacatg tgacagtttt 1288021 tcagcaaatg gaagctgttt gcgttccgcc attgcaaatg aaacacgcgg gaaagaaagc 1288081 acctttccat ttaagcaccc aaagatgctg acgataatcc ctacactgat cagctttccg 1288141 ccaattgaac cgaacagcat ggttgcagcg gtgcttgtcg cattttcacc aagcgtgaca 1288201 atttcgttcg ctgacaggat gtgaagcaat gcaaaattaa tgaaaatata gatcgccgtt 1288261 acaattaata atccgcccgt catagcgcgt ggcagcagct tttcgggatt tttcatttct 1288321 ccgccgagag cggcaaggag aatccatccg tcataagcaa acaacgtagc taaaatagcc 1288381 gccccgaagt tcatatcaga aatgctttcg tttactgctg tgaagatgtg ctgatcgcct 1288441 ttccaaaggc caaagacgat gatgcaggca atcggaatca gttttccgat cgttgtcagc 1288501 gtttggacaa aaccgccgta ttttgtaccg ataatattaa tgacgcataa aaagagaact 1288561 gctataattc caatgacttt tgatagtcca gatccccagc cgaaaagatt cgccattaaa 1288621 gatccaaaat ataaacccag cgcgccaata atcgccgggc cgtaaatgat aatctgcacc 1288681 cagccgcaca aaaatcccca aaactcgccg tacacttctt caaggtacgt ataaagcccg 1288741 ccggtttttg gaatctgcgt tccgatttcc gcgattgtca aaccgcccgc cagtgttaaa 1288801 ataccgccta acagccaggc gaaaagcgcc atttttgaat cacctgaata agcaagcaca 1288861 gcgccgggct tcataaaaac accagaaccg ataatggttc cgatgacaag agtaagggca 1288921 aacaagaggc ctatctcttt tttcaaaccg ttgtcttcag tatgcatgtc cttaacctcc 1288981 tatgatgttg aagcttcatg ttgaagaatc tattttttca tattgtaaac cctattttag 1289041 aaaagtgaaa taaaataaat tttctgattt tcgaaatttg ctttgtgtac agcagataaa 1289101 actgtagaaa tacctgtttt aatggtctat aaacgaataa aattcataat ttttatttac 1289161 aaagttcgtg ttttatgtat taggatttta gccggtacag aggggagatg agaattcaga 1289221 aaatgaacga accttcggtg aagctgatat gttgactttc tcatgcgaat aaaatacttt 1289281 gttattagaa caataaatat acaattatga tatgatatct cgaaatcgag ataaaataac 1289341 ctggagggac agcatatgaa agttaacggc attcaccacg tatcggcatt aacggccgac 1289401 gcacaaaaaa acttggattt ctataagaaa gtattaggat taaagctcgt caaaaaatcc 1289461 gtcaatcagg atgaaccgac aatgtaccat ctgttctacg gagatgaagt ggcaaacccg 1289521 ggaactgagc tgacgttttt cgagattccc cgcattgcac cgtttcatgc gggaacaaac 1289581 agtatttctt ctattggatt gcgcgttcca ggcacagaag ccctgcatta ctggaaagaa 1289641 cgttttgaag agcagcaagt aacgcacagc ggcatctcca aaagagccgg acgtgacata 1289701 ttggcatttc aagatcatga ggggcagcga cttgtgctga ctgctgatga ggaaggaaaa 1289761 ggatatggcc tgcctgttaa acagagcggc attccggaag aattttcgtt tcgcgggtta 1289821 gggccggttg aactgactgt gccatatgct gaaccaactt tacacgtatt gacgaatatt 1289881 cttggattta cagaaatcag ccgtgaacca gtcgaagggc aaggaaccgc cgttattctg 1289941 gaatcaggag aaggcggtgc tgcaacggaa atccatttaa tagaaagaaa cgatcttccg 1290001 cgagagcgtc aaggcaaagg gagtgttcac cacgtcgcat ttcgggtaag agatgaagaa 1290061 gaacttgccg ggtggcaccg gatcatcagc cgcgaaggct ttagcaattc aggcatagtt 1290121 gagcgctact atttcaaggc gctgtatttc agagaaccga acggcatttt gttcgagtta 1290181 tcaacagacg gaccgggctt tatggtagat gaaaatcttg atgagcttgg ccaaacgatt 1290241 gctcttccgc catatctaga gcatcgaaga gcagaaattg aagcaaaatt gaaaccgatc 1290301 caataaattg tgattctttt gccttccggc gccgccggag ggcttttttt attaccataa 1290361 ttaattttga cctaaacagc atgccttatt agggaggaaa tatcagatgc tgattgggag 1290421 aaatggctta aaaccctttg caaatatggg tgattggtat ggaatggcct cggcaaaaat 1290481 attgtctttg tttattaata gtttattcat atttgcttgt tacactattt caaagttaga 1290541 caaaaaggag tgaaaaataa gtggaaaaga aaaaacgcga gctggatatc gtcctcctcc 1290601 tcattttgct cgcatctgca ttcttaaata tctataacat ttggaaggac gacacggtga 1290661 atccttatta caccgcggca gttacaagta tgatgcaaag ctttcataat ttcttttatg 1290721 cttcgttcga tgctgccggc tttataacag tagataaacc gcctgttaca taccaaatcc 1290781 aaacgatcag cgcactgata ttcggtatgc acggctggag cgtcatcctg cctcaggcac 1290841 ttgctggtgt aggttctgtc cttcttatgt acttgctgat aaagccgaca tttggaaaaa 1290901 cggcggcgcg tattgcctca tttgttatgg catgtacgcc gatagctgta gctgtagcac 1290961 gtacaaacaa tgttgatgca ttactggtat ttttcttatt gcttgctaca tggcttctct 1291021 ttaaagcgat cagaaaagga aagctgatct ggctgttagc agcatttttc gttgttggag 1291081 taggttttaa tacaaaaatg ctgcaggctt acatgatttt accggctttc ttattgttct 1291141 atctgattgc ggcaaacgcc acaatcaaga aaaaaatcgt ttcattggta agtgcgttag 1291201 ccgtattagc agccgtttcg ttatcgtggc cgctcattgt tgacaatatc cctgcaagca 1291261 agcggcctta tatcggaagc agccaaacca actctgtttt ggaattggct ttcggctata 1291321 acggaatcca gcggctgaca ggccaaaatt caggcggcgg ccagggtgcg ccaaacaaag 1291381 acgcttcaaa agaaatgtct tcttctgata acactcaagc accgcctaat cagtcatcaa 1291441 gcaacagctc atcaagcgat ggtaaatcct caaatggcaa tatggcggcg cctccatcca 1291501 atggccaaat gccaagcggc ggtcaaggag gccctccaag cggcggagat ggcggccaag 1291561 gcggacccgg cggagacgga gggaaaggcg gtacaggaac cggttcgaaa atgcaatcag 1291621 gttcagggat gtttggaacg ggaacacctg gtccactgcg gcttttccaa caagagttat 1291681 ctgatcaaat cagctggctt ctgccatttg cgatatttgg aatcgcaggc ttactgatcg 1291741 ctggcgcaag agaaagaaga agattatctg tagagcagaa ggaaacggtg ttctgggttg 1291801 cgtggcttgt accgattgcc ggattcttca gtgtcgcaga atttttccat cattattatc 1291861 tcatcatgct ggcaccgccg attgcggctc ttgtcggtgc ggggtgggtc gctcttgttc 1291921 atctgtaccg caatcagaca ggctggaaag catggctttt gccgggagca attattgcga 1291981 caactggatt tgaattgttt attctcagaa actacaacga tcaaatcggt gttggatgga 1292041 gtatcggggt aggtgttatc ggcgtgttgt cagcgattgc tttgctgctg tttaaacagc 1292101 gccaaaaacc gttcagttat tatgtttcac ttgcagctct cctcgcattg ctggtgatgc 1292161 cgatgtattg ggcaagtaca ccgcttctgt acggaggcaa cagctcactg cctgaaacag 1292221 gccctcaact cgcatcaatg agcggaaaag gcatgggaat gtctgatgcg actgtaaatg 1292281 aaaaactgat caaatatcta gaggagaata actccggagc tgaataccta ttcgccacaa 1292341 ccgattcgaa cacagcggca ccatatatca ttaaaacgaa aaaagctgtc atggctattg 1292401 gtggatacag cggttctgac ccggcaatca cactgactca attcaaaaaa cttgtaaaag 1292461 aaggaaaagt gaaatacttc ttggcttctg gaatgggaag aggcggaaac aatgacattg 1292521 ttgaatgggt tgagaaaaat ggaaaagaag tagcatcaga aaaatggcaa tcaagttctg 1292581 atcaaaaaac agaaaatact gattcagctg atacatcaag cagcaaggct tcaggtgaaa 1292641 acggcaaaat gggcggacct ggcggaatga atcagtcagc aacattatac gaactacatg 1292701 ctgatgaata ggaggcaaaa acatgagcag acatattcaa tattcaattg ttgtacctgt 1292761 gtataatgaa gagcttgtca ttcatgaaac ctatcagcgc ttaaaagagg tcatggatca 1292821 aacgaaggaa aactacgagc tgctttttgt caacgatggc agcaaagacc gcagtattga 1292881 gattttaaga gagcacagcc tgatcgatcc gagagtgaaa attattgatt tttcaaggaa 1292941 ttttggacat cagatcgcca ttacggcagg tatggattat gcacagggga atgcaatcgt 1293001 cgtcattgac gccgatttgc aggaccctcc tgaactgatt ttagaaatga ttgaaaagtg 1293061 gaaggaaggc tatgaagtcg tgtacgccgt acggactaaa cgaaaagggg aaaccttttt 1293121 caaaaaacaa accgcggcta tgttttaccg gcttctcagc ggtatgacag atattgatat 1293181 cccgattgat acgggggatt ttcgcctcat ggacagaaaa gtctgtgatg aaatgaagag 1293241 attaaaagaa aaaaatccat ttgtaagagg gctagtcagc tgggtgggtt tcaaacagac 1293301 agcggtcgag tatgtacgtg atgaaaggct cgccggagaa acaaagtacc cgctcaagaa 1293361 aatgctgaag ctgtcaatgg acggcatcac gacattttca cataaaccgc tgaagctggc 1293421 aagctatgcg gggattttaa tgtcaggtac tggatttctg tatatgttta tcgtgctgta 1293481 tctgaagcta ttcacagaca gcacgattac cggctggtca tcacttattg tgatccagct 1293541 cctgttcagc ggcattgtcc ttctgatttt gggcgtgatt ggcgaatata tcggcagaat 1293601 ctacgatgaa gccaaagaca ggccgcttta catcgtccaa aaatcgtatg gaattgaaaa 1293661 taaaagactc tatagagacc agcatatgtc ataacctcaa accccctgtc cgtaatggac 1293721 agggggtttt tatgctctga gcacgatcta aagcaaaaga tgctgataga tatatggaaa 1293781 ttgggtaaag aagagattgt gagcttgtac tgcggttcag tcatgctgaa ataaaaacag 1293841 caaaacttaa agatttcgtc ctcggctttg ctgcatgtca gctgttatat tggggggctt 1293901 ttaagaaacg catgattaga gccgtaccag ttatgtttaa tagaatactc gtacccaata 1293961 caattcccca cgtcaacgtc gattcagaga gaagaaagct cagcaaaaga aaagccaatc 1294021 ctgcgcagat catacccagt cccacggttt tcatgttcat gcctcctagc aaacgatgtt 1294081 tctagcatct gatgtgaatg atgtcaatct gtatgatata cggatatctc gtcagaaagt 1294141 ttcatagaac aattaggtct tttatctaat aaaaagcctc agaccgcttt tacggcctga 1294201 ggcattatgt cttacgaagt tttctcttct ttttgatcca gtttaatttt tttcgtcatt 1294261 tctttgccgt ttcggagaat tttcacttca acggtatcac cgatctttgc gtctttatat 1294321 aagatattgc gcaattcact gcctgtatca atttctttac cttttaggcc gatgataata 1294381 tcctccgctt ttaatccggc cttttcagca ggagagcctg aagcgacctc acggatgtaa 1294441 acgcctttat tcagctggct gccgaacagg ccgagtgtgc cttcttggta attttgcggc 1294501 acttgctcta gatcaagcat gctgacaccg atatatggac gttcaatttg tcctttagac 1294561 agcaattctt cagcaatcgg ttttacgtca ttgcttggaa tggcgaatcc gataccctca 1294621 acatcatcct cactgatttt catactgtta atgccgacaa ttttgccgtc tgtatttaac 1294681 aaaggaccgc cgctgttacc tggattaatt gctgcgtctg tctgaatgac gttaatgctc 1294741 gtttcgccgg ctgatgtaga cattgaaacc gttctgtcca cgccgcttac aattccttgt 1294801 gttactgtgc gggacaggtc ttttccaagc ggatccccaa tcgcaataac ggtctcgcct 1294861 gttctaagat cagatgaatc accgaagttt gccacttttg tgacgtggtc atcactgatt 1294921 tggaggacgg ctaaatcagt taacgagtca ctgcctacca gctttgcagt aacctcagtg 1294981 ccgtcatata aagatacctt cagtgatgat gccccttcta cgacgtggtt atttgtaatg 1295041 atataagcct tgccattctc ttttttgaaa atgacacctg accctgaacc gctttctgta 1295101 tcttcgctgg aatcagaaga actagagccg aacaaagagc tgtttgattg tgcctgaaga 1295161 tttgtaatac cgacaatcgc tggtgaaagg tcttctacca tatctgagat tttagaagag 1295221 tcctcgctct tgaatgcaga tgagctgctt gagctttttt tagattcaga ggaggtgctt 1295281 gttgctgtaa cagattgcgt ttgctgctgg ctggatgatt gttttgcagt gtcctgagaa 1295341 tcatggtcac caagcggtgt aaacgtgtaa atgccaagag caagactgcc gccgatcact 1295401 ccgccaagca acggtctgaa ccatccgaat cctcgttttt tcttctcctg atcatgaatg 1295461 acattgcggg ccgagtagga ggcgctctga tcgttctctt tcgttaaaaa gacctcattc 1295521 tcattacctt tcgttctgtt ttcatcacga tagttatcca tcatgttcac tccgtttctc 1295581 tattttcaca tgtctattta tattgatagg tttatgactt gagtttatca taaacaaaaa 1295641 ctgtgggata aaaatgaaaa gattatggga aattgtgaaa aagtgcggaa aacggtacac 1295701 ttcatattgt atatgaaagg actgagtcga tggaacagat tggattgatt ggatatggca 1295761 gcatggcgga tatgatcgct agacagctgt tgaaacatga acaaataaaa gagaatgagc 1295821 tatttattga gacgagaacg aagggggagc ggctgcgggc actcatgtca gattatccaa 1295881 acgtatcggc tgatccgttg gagaattggg caaatacgtg ccaattgatt ttgatatgcg 1295941 tcccgccact ccatgtcatc gaaacaatgc gccgtctgta cccgtatgtg aacagaaata 1296001 ctcacatcgt atccatagct gccggtgtgc cgctgcgtct tttggaggca gaaacagaag 1296061 ccggtatctc acgtgttatt cctgccatta cgtccgaagc agaagccggc atctcacttg 1296121 tcgttcacag tgaagcactg gctgcagaga aaaaagaacg tctgaatgaa ttgttatcgg 1296181 ttttcagccg tgtacgggaa atcaaagaat cgaatttaga tgtggccagc aatttaacga 1296241 gctcggcacc gggattcata gctgcaatct ttgaagaact ggcactgtct gccgtcagaa 1296301 acagcagcct gtccaaagaa gaagcctttg attttctgat tcattcgcta tacggaactg 1296361 gcaagatgct gatcgaaaaa aatatgtctt tcgaggagac gctggaacgt gttgcaacca 1296421 aaggcggaat aacgggagag ggagctgagg tgatacacgc ctctgtgccg gacgtttttg 1296481 atgaggtatt tgaaagaacc ctgagaaaat atgaactgct tacagaacag gttggtaaac 1296541 aaacatgaat ccttgaaaga ggattctttt tttatcactg aatgattgag atttttccca 1296601 gttatattgc atttttcctc tttttttaat ataatttgtt agaatattca taatttagta 1296661 aaaaaggagg agcgttatga aattgtacat gtcagtagat atggaaggta tttcgggtct 1296721 tccggacgat acctttgtgg attccggcaa gcggaattat gaacgcggac ggcttatcat 1296781 gactgaagaa gcaaactact gtattgctga agcgtttaac agcgggtgta ccgaggtgct 1296841 ggtcaatgac agtcattcga agatgaataa tctgatggtt gaaaagcttc accctgaagc 1296901 agacttgatt tctggtgacg tcaaaccatt ttcaatggtg gagggactgg atgatacgtt 1296961 tagaggcgct ttgtttctcg gttatcatgc gagagcctcg actcctggtg tcatgtcaca 1297021 cagcatgatt ttcggcgtcc gtcattttta cataaacgat cggcctgtcg gtgagcttgg 1297081 attaaatgca tacgttgccg gttattatga tgtcccggta ttaatggtag ccggggatga 1297141 ccgggcggcg aaggaagcag aagagcttat cccgaacgtg acgacagccg cagtcaaaca 1297201 aaccatttca agatccgcag tgaagtgctt gtcgcctgcg aaagccggac ggctgttgac 1297261 agaaaaaacc gcatttgccc tgcaaaacaa ggacaaagtc aagccgctca caccgcctga 1297321 caggccagtt ctgagcattg aattcgccaa ttatggccaa gcagaatggg cgaatctgat 1297381 gccgggaacg gaaatcaaga cgggaactac aaccgttcaa tttcaggcga aggacatgct 1297441 tgaagcctat caggcgatgc ttgtcatgac tgagcttgcg atgcggacat cattctgcta 1297501 aaggggtgtt ttaggctttg gcgcgataca tgataaagcg tttttgggca atggcagcta 1297561 cgattttggt gattaccacc ctgacttttg ttctcatgaa ggtcattccc ggatctcctt 1297621 ttaacgagga gagaggcaca aatgaagccg ttcaaaaaaa tctcgaagcc tactatcact 1297681 tagacgatcc tctcattttc caatacattt tctacttaaa atccatcatt acattcgatt 1297741 tcggaccttc aattaaaaaa ccgtcggaca gcgtaaatga tatgctggaa cgcggatttc 1297801 ccgtttcctt tgagcttggg atgacagcga ttgtcattgc tgtgatttct gggctggtgc 1297861 tgggcgtaat cgctgcactc cgccgcaatg gctttttgga ctacgccgcg atgagtcttg 1297921 cagtactcgg catctccatc ccgaatttta ttctggcaac attgctcatt cagcaatttg 1297981 ctgtcaatct caaactattt cccgctgcga catggacgag cccgattcat atggtgcttc 1298041 cgaccgcagc gcttgctgta gggccaatgg cgatcattgc caggctgaca cggtcgagca 1298101 tggtcgaagt tctgacacag gattatatcc gcacagcaaa agcaaaaggg ctttctccgt 1298161 tcaaaattat cgtaaaacac gcactcagaa atgcactcat gcccgtcatt accgtcctgg 1298221 gcacactcgt cgccagcatc ttaacaggaa gctttgtcat tgaaaaaatc tttgccattc 1298281 cgggaatggg aaaatatttt gttgaaagca ttaatcagcg ggactacccc gtgattatgg 1298341 gaacgaccgt tttttacagc gtcattctga ttatcatgct gtttttggtc gatttggcct 1298401 acggtctctt agacccgcgc attaaactgc ataagaaagg gtgaagcgtg tgaatctccc 1298461 tgtacaaacg gatgaacgcc agccagaaca gcacaatcag gtgcctgatg agtggtttgt 1298521 cttgaatcag gaaaaaaatc gggaagccga ttcggtcaag cggccgagtt tgtcatacac 1298581 gcaggatgcc tggaggaggc tgaaaaaaaa taaattagcg atggccggac tctttattct 1298641 tttatttctt tttgtcatgg cagttatcgg gcccttttta tcgccccata gtgtcgtacg 1298701 ccaatcgctg acagaacaaa atcttccgcc ctcagccgat cattggttcg gcaccgatga 1298761 actcggccgg gatgtgttta cccgaacatg gtatggcgcg agaatctcgt tgtttgtcgg 1298821 cgtgatggca gcactgattg attttttgat cggtgtcatt tacggaggcg ttgccggcta 1298881 taaaggcggc aggattgaca gcattatgat gcggattatc gaagtgctgt acggactgcc 1298941 gtatctgctt gttgtcattt tgctgatggt gctcatggga ccgggactgg gcacgattat 1299001 tgtggcgctg actgtgaccg ggtgggtcgg catggcgaga attgtaagag gccaggtgct 1299061 tcagattaaa aattatgaat atgtactcgc ctcgaaaacc tttggcgcga aaacctttcg 1299121 catcatccgg aagaatttgc tgccgaatac tatgggagcg atcatcgtac aaatgacatt 1299181 aaccgtacct gccgccatat tcgcagaatc atttttaagc tttctcggcc tgggcataca 1299241 ggctccgttt gcaagttggg gcgtgatggc gaatgacggc ctgcctacga ttttatctgg 1299301 gcattggtgg cgcctgtttt ttccggcctt tttcatatct ctgacgatgt acgcgtttaa 1299361 tgtgctgggg gacggattgc aggatgcgct tgaccctaag ctgaggaggt agctgtatgg 1299421 aaaaagttct gtcagtccaa aatctgcacg tgtcttttac gacttacggc gggacggttc 1299481 aggcggtcag aggggtgagc tttgatttgt ataaaggaga aacctttgcg atcgtcggcg 1299541 aatccggctg cggcaaaagc gttacctccc aaagcatcat gggcctgctt ccgccttatt 1299601 cggcgaaggt gacagacggc aggattctat ttaaaaacaa agacctttgc cgtctctctg 1299661 acaaagaaat gagaggtata aggggagccg acatttctat gatttttcaa gacccgatga 1299721 cggcgttaaa ccctacgctg actgtcggcg accagctggg ggaagcgcta ttgcgccaca 1299781 aaaaaatgag caaaaaagcg gcacggaaag aggtgctttc catgctgtca ttggttggta 1299841 ttccagatcc cggagagcgc ctaaagcaat atccccacca attcagcggc ggtatgagac 1299901 agcggattgt cattgcgatg gcgctgattt gcgagcctga tatcttaatt gcggatgaac 1299961 cgaccaccgc cctggatgta accattcagg cacagatttt agagctgttt aaagagattc 1300021 agagaaaaac ggatgtgtct gtcattctga ttacgcacga tttaggggtt gttgcccagg 1300081 tagctgacag agtcgcagtc atgtatgccg ggaaaatggc ggaaatcggc acaagaaaag 1300141 atatttttta tcagccgcag cacccatata caaaaggcct gctgggctct gtcccgcggc 1300201 tggatttaaa tggcgctgag ctgaccccga ttgacggaac gccgccggat ttattttcgc 1300261 ctccgccggg ctgcccgttt gccgcccgct gtccgaacag gatggttgtg tgtgacaggg 1300321 tgtacccggg ccagacgatc agatctgact cgcacaccgt caactgctgg ctgcaggatc 1300381 aacgagcaga gcatgcggtg ctgtcaggag atgcgaagga ttgaacatga aaagggggaa 1300441 gaggatgaaa cgagtgaaaa agctatgggg catgggtctt gcattaggac tttcgtttgc 1300501 gctgatgggg tgcacagcaa atgaacaggc cggaaaagaa ggcagtcatg ataaggcaaa 1300561 aaccagcgga gaaaaggtgc tgtatgtaaa taatgaaaat gaaccgactt cattcgatcc 1300621 gccgatcggc tttaataatg tgtcatggca gccgttaaat aacatcatgg aggggctgac 1300681 gcgtcttggc aaagatcatg agcccgagcc ggcaatggcg gagaaatggt ctgtttcgaa 1300741 agataataaa acttacacat ttacgattcg ggaaaatgcg aaatggacaa acggagatcc 1300801 tgtaacagcc ggagacttcg aatacgcgtg gaagcggatg cttgatccga aaaaaggcgc 1300861 ttcatcggca ttcctaggtt attttattga aggcggcgaa gcatataaca gcgggaaagg 1300921 gaaaaaagac gatgtgaagg tgacggcaaa ggatgatcga acccttgaag ttacactgga 1300981 agcaccgcaa aaatatttcc tgagcgttgt gtccaatccc gcgtatttcc cggtaaatga 1301041 aaaggtcgat aaagacaatc caaagtggtt tgctgagtcg gatacatttg tcggaaacgg 1301101 cccgtttaag ctgacggaat ggaagcatga tgacagcatc acaatggaga aaagcgacac 1301161 gtattgggat aaggatacag tgaagcttga taaggtgaaa tgggcgatgg tcagtgacag 1301221 aaatacagat taccagatgt ttcaatcagg ggaacttgat accgcttatg tccctgctga 1301281 gctgagtgat cagctgcttg atcaggataa cgtcaatatt gttgaccagg cgggtctcta 1301341 tttctatcga tttaatgtca acatggagcc gttccaaaat gaaaacatca gaaaagcctt 1301401 tgcgatggct gtggatcaag aggaaattgt aaagtacgtc acgaaaaata atgaaaaacc 1301461 ggcgcacgcc tttgtatcgc ctgggtttac gcagcctgac ggcaaagatt tccgtgaagc 1301521 aggcggagac ctgatcaagc ctaacgaaag caaagcgaag cagctgctcg aaaagggcat 1301581 gaaggaagaa aactataata agcttcctgc gatcacgctt acttacagca caaagccgga 1301641 gcataaaaag attgccgaag ctattcagca aaaattgaaa aatagccttg gagtcgatgt 1301701 gaagctggcc aatatggaat ggaacgtatt tttagaggat caaaaagcgc tgaaattcca 1301761 attctctcaa agctcatttt tgcctgatta tgcagaccct atcagttttc tggaagcctt 1301821 tcaaacggga aattcgatga accgcacagg ctgggccaat aaagaatacg atcagctgat 1301881 caaacaggcg aaaaacgaag ccgatgaaaa aacacggttc tctcttatgc atcaagctga 1301941 agagctgctc atcaatgaag cgccgatcat tccggtttat ttttataatc aggttcacct 1302001 gcaaaatgaa caagtaaaag gaattgtccg tcaccctgtc ggctatatcg atttaaaatg 1302061 ggcagataaa aactgatgga ggcgattgag gaaatactgc ttctttatgc gaaggagcgg 1302121 tattttttct ctttcttgca cgtatacgta gggtgcagag caaatgaaag gagtgttttc 1302181 gttgaattac aagccgaaag cgttgaacaa gggtgataca gtcggagtga tcgcgcccgc 1302241 aagtccgccg gatccaaaaa agcttgacac cgcgctttta tttttagaag agctcggtct 1302301 tcaggtgaag ttgggcaagg cgctgaaaaa ccagcacggc tatttagcgg gacaggatga 1302361 tgagcggctg gcggatctcc atgagatgtt cagagacgat gaggtaaaag cagtgttgtg 1302421 cgcatgcggg ggttttggga caggacgtat cgccgcgggc attgatttca gcttgatccg 1302481 caaacaccct aaaatctttt ggggatacag cgatattacg tttttacata ctgccattca 1302541 tcaaaacaca ggtcttgtca ctttccatgg cccgatgctc agcacggata ttggccttga 1302601 cgacgttcac ccgctgacaa aagcgtcata taagcagctc ttccaggaga cggaattcac 1302661 ctatacagaa gagctttctc cgctgaccga gcttgttcct ggaaaagcgg aaggcgagct 1302721 tgtcggggga aatctgtctt tgctgacgtc tacactgggc acgccatttg aaattgatac 1302781 gagaggaaag cttctgttta ttgaagatat tgacgaggag ccttatcaaa tcgaccggat 1302841 gctgaatcag ctgaaaatgg gggggaagct gacggacgcg gcgggaattc tagtttgtga 1302901 ttttcacaat tgtgtcccgg tgaagcgaga gaagtctctc tcgcttgagc aggtgctgga 1302961 agactatatt atttctgcgg gcaggcctgc tctgagagga tttaaaatcg gccactgctc 1303021 gccaagtatt gccgttccga tcggtgcgaa agctgctatg aatacagcag aaaaaacagc 1303081 cgtaatagag gcgggcgttt cagaaggggc gctgaagaca tgaaaatcat tcgaatcgaa 1303141 acaagccgaa tcgctgtccc gctgacaaag ccgtttaaaa ccgcacttcg cactgtgtat 1303201 acggctgaat cagtcatagt aaggattact tatgacagcg gtgcagtcgg atggggagaa 1303261 gcacccccga cgttagtgat tacaggagac agcatggata gcattgaaag tgccatccac 1303321 catgtgttga agccggcatt gcttggaaaa agcctggcgg gctatgaggc cattctgcac 1303381 gacatccagc atcttcttac aggaaatatg agcgcgaagg ctgctgtaga aatggctcta 1303441 tacgacggct gggcgcagat gtgcgggctg ccgctttatc aaatgcttgg cggatatcga 1303501 gatacgctgg aaacagatta tactgtcagt gtcaactcac ctgaagagat ggcagctgat 1303561 gccgagaatt atctcaaaca aggctttcaa acgctgaaaa taaaggtcgg aaaagatgat 1303621 attgcaacag atatcgcccg tatccaggaa atcagaaaac gtgtcggatc agctgtgaaa 1303681 ctgcgtttag acgctaatca ggggtggagg ccgaaggaag cggtaactgc cattcggaaa 1303741 atggaggatg cgggcctagg cattgagctt gtcgagcagc ctgtccataa agatgatctc 1303801 gctgggctta aaaaggtgac agatgcaaca gatacgccga ttatggctga tgaaagtgtt 1303861 tttacaccgc gccaggcgtt cgaagttctg caaacccgga gcgcagactt gatcaatatt 1303921 aaattgatga aagcgggcgg catcagcgga gcagagaaaa ttaatgccat ggcggaggcc 1303981 tgcggggtgg agtgtatggt cggcagcatg atcgaaacga agctgggcat tacggccgcg 1304041 gcgcattttg cggcaagcaa gagaaacatc acacgctttg attttgacgc gccgctgatg 1304101 ctgaaaacag atgtattcaa tggcggcata acatatagcg gcagcacgat ttcgatgcct 1304161 ggcaaaccgg gcctcggaat catcggggct gcgcttttga aaggggaaaa agagcaatga 1304221 tgcacactgt catatcagca gtggccaaca tctggacagc gcctgattca cctcgtccgt 1304281 ctgatcaatt catgcttcaa ccgactgtaa tgatcagaga ctggctggag cgcatgacgt 1304341 atgatgaacg gcttggatta tgtacagaca atgtaatcca aactcaggtt ctctttggcg 1304401 aaaaggtact tgtgacggcg gaacaggggg aatgggtttc tgtgatcgtg cctagccagc 1304461 catcccgaaa ggatccgcgc ggatacccgg gctggatgaa aaagtaccag ctggaaaaaa 1304521 caaagcccat ccatacacaa cacgatgtga tgatcagcaa acctgctgcc tttttgtaca 1304581 gaagcaatgg ggaaaaggag atcgaattaa gctttttgac agttctgccc cttattgcaa 1304641 aagaaaacgg atattttaag gtttcgaccg tttttgggga aaggtttgtg aggcaaagtg 1304701 atgcagtgcc tgtcagccaa cagaaaggga ctgctgaaga catcattcaa acgggtgcgt 1304761 tttttcttgg ccttccctac ctgtggggag ggatcagcgg gtttgggttt gattgctccg 1304821 gatttatgta cagtatattt aaggcgaatg gatacagcat cccccgtgat gcgggagatc 1304881 aggctaaggc agggaagggt gtcccgcttg atgatatgaa agccggtgat ctgctgtttt 1304941 ttgcttatga ggaaggaaaa ggagcgattc atcacgtcgg tctgtatgta ggcggcggga 1305001 aaatgcttca ttctccaaag acagggaagt caatcgaaat cctcacatta acagagacaa 1305061 tctatgaaaa agaattatgt gcggtgcgcc gctgtttttc agaataagga gggagacaaa 1305121 tgaggcgact gcctttgtta gaggtcagcc agctgaaaat gcattttgac gcagggaaaa 1305181 agcggacagt caaagctgtc gacggggtca cctttcagat tcgtgaagga gaaacgttcg 1305241 ggctagtcgg ggaatcaggg tgcgggaaat caaccttggg gagagtgctg atgcgccttt 1305301 atcagccgac agaaggaagc gtgacatacc gcggcacaaa tcttcatgca ctaagtgaaa 1305361 aagagcagtt tgccttcaac cgcaaactgc agatgatttt tcaggaccct tatgcttcac 1305421 ttaacccgcg catgaccgtt cgagaaatta ttttggagcc gatggagatt cataatctct 1305481 acaataccca taaagcacgg cttctcgtcg tggacgagct gcttgaggca gttgggcttc 1305541 accccgattt tggcagccgt tatccgcatg aattcagcgg cgggcaaagg cagagaatcg 1305601 ggattgcgag agcactgtcg ctgaatcctg aatttatcgt ggcggacgaa ccgatttctg 1305661 cacttgatgt ctctgttcaa gcgcaggtgg tcaacctgct gaagcggctt caaaaagaga 1305721 aagggcttac gtttttattc attgcccatg atctttcgat ggtgaagcat atcagtgaca 1305781 ggatcggtgt tatgtactta ggacacatga tggaaattac agagagcggc accttgtatc 1305841 gtgaaccgct ccatccctat acaaaggcgc ttttgtcctc gattccgatt ccagatcctg 1305901 aattggagga caagcgtgag cgtattctct tgaaagggga gctgccgagc ccggtcaatc 1305961 cgccaagcgg ctgcgtgttt cgtacccgct gtccggaggc gatgcctgaa tgtggagaat 1306021 ctcgtcccca gcttcaagaa atcgaacccg gccgttttgt cgcttgccat ttgtatcgaa 1306081 atgctgaaac gaaggaaaaa gtaagataaa taaaaagagt ggctcctttt tactagagcc 1306141 actccatttg tttatacttg atgtaaaaac tttacacaaa ccgggtaagg gacagaaacc 1306201 gttgatggga ggagtgtcaa tcggccggtt tctttgtctc tttcaaacaa gacaaggttg 1306261 cctgtttctt catttgaagc aacgaggaac ccttccgttg ggtcaaatac aaagtcacga 1306321 ggccagtttc cttctgtcga cactctttct acgaaagcca gctctcctga atattgattc 1306381 acttcaaata cggcgatact gtcatggccg cggtttgcga cataaacaaa acgtccgtcc 1306441 tgcgtgacat gtattgcgct tccctggctg ttatctgtaa aatcatcagg gatggcagaa 1306501 acgacttgga tttctctaaa ttcgccggct gtcgggttgt attcaagcgc aatcacttca 1306561 ttgcttaatt ctgtcatgac ataagcgtat ttttctttcg gatgaaaagc gatatggcga 1306621 ggtcctgcac cgggagcgaa ggaatggctt ccggattcag tcaacacacc gtctttaagc 1306681 ttataggtgt agagcttatc tatacctaaa tcaaccgcta ccacataatt gtgttcaggt 1306741 gtgaaccccg cgtagtgtgt atgcggtttt tcttgtcttt cgtgcggccc ttttcctgtg 1306801 tgagcggcct ctgaaacagg tgattgcaag ctgccgtctt cctgaaccgg aaaaacgtgt 1306861 accttcccgc tgtgataatt ggcagtcagt acgaattgat tttgatcatc aacgcttacg 1306921 tggcatggcg aagggccatc aattaactga tgattcagaa atgtcaattc gccgctgttt 1306981 ttatcgattt gataggcagc aactccgcct tggccgtctg ctttttcgat ggaataaagg 1307041 atggtgttgt ttttattcgt cgccacatat gtcgggttgc ccagcttagc ggccagcttt 1307101 ggctcgctga gtgctttttt ctcagtatca agctcaaatg aataaattcc ttcgcttccg 1307161 ccttttgtat atgttcccac atatcctatg tattttgtca tgcgatttcc cccttaaaaa 1307221 tgatgtcacc tctatattaa cgtatcttga taaaataagc tgttcaaaac atgaaaaagg 1307281 ggaagattct tcattcgcct cgaatcagcg gcattgtgca gcacctgaag gagccgcctg 1307341 atttaataat ttctgacagg tcaatttcga taatgtgata gcctcttttc gatagctgtt 1307401 gattgacatg gcggttgcca gggagactga tgatcgtttt ttttccgatt gaaaggacgt 1307461 tggtgccaag cgtaaattgt tcgtcctcgg gcacctcaat aagatcataa cgttttgcca 1307521 gcatatcggc tgcatctggc tcaatggcct gtgaataaat taacgcttcg ctttcagata 1307581 taatgttaaa tacgcagtcc aaatgcaaaa atttttcatg aagcttcact ggaacgatcg 1307641 tatattcagg aagtgcctct tctagctggc cgatagctga aatgtcggtg cgctggctga 1307701 ttccgacata gacaatgtca tcatcgataa tgacgtctcc gccttcaata ctcgtatcaa 1307761 gcatgcgggt gtaagagata ccttggctgt gaaaaaaatc ttttataacg gcttcttctc 1307821 cttggcgaat cggttcagtc atgcttgaca gaaaggcttt ttctccgatg acaaatccta 1307881 tgtccctagt aaaaacctgt tctgggagtc cgtcgcgaac gggcaaaagg acgacctcaa 1307941 cgttgtgtga cctaagtgcc tccactaagc ggctgtgctg gtcgttagcg gtttttacat 1308001 gaatattgtc atcttcaaaa tgtttttgtg tttcgtttat aacatctttt atggtcatgt 1308061 gctcaggttt gcataagatc actttttgaa gtgtgccgta ttccgttcgg cataccgttt 1308121 tgtgctgaga tttcgggatg gatacgtcca tttgtttttc ctcctaaagt gtgaagaata 1308181 catttattat tccctcatca tgaaaatcat taaaccattt taaattttag acaaatggaa 1308241 gagaatattg tttaatagga gaatataagt gcatttagct aaaagatcag acatcaaagg 1308301 ggagaaaggt atggaaacac cggaaacaag attttgtaaa gagtcaaagg ttgtgaaaac 1308361 cagcagggtg ttcccgcttg acacgaacaa ccataatacg ctgtttggcg gaaaattaat 1308421 gagctacata gacgacattg cctctatttc agcggcgcgc cattgcagac gtgaaacggt 1308481 aacagcttca atggattctg tagatttttt aaagccgatc gggcaaaagg attctgtctg 1308541 cctagagtca tatgtgacat gggtcggcac atcttccatg gaagtatttg tgaaagttat 1308601 taaggagcat ttgatgactg gcgaacggga actcgctgcc acatcctttt tgacatttgt 1308661 cgcattagat tcaaatggca agccggtgcc tgtaccgagg gttgtaccgg aaacagaaga 1308721 agaaatcatg ctgcataata cagctgtaca gcgtgctaat gaacgtaaga accgcaagag 1308781 acacagccag gcgcttgcaa atgcgctcgg aactgataag ccttggtgaa cgttaaaccc 1308841 aaaacataag ttgttttggg tttttttgta cttttcaatg gtgattatta caatggttag 1308901 tccgtttttg ctaggggatt ctataaaaaa gcaacaaatg tcatgttaaa ttgataattt 1308961 tgtgacaact ttattaaaga ttcattttag atatatcttt tattcgtaag atcatgtatt 1309021 ttaaagatat attttaaata catcttttcg aaaggattgt ttataaaatg ttagataaca 1309081 aaacaatcga aattattaaa agcactgtac ccgtattgca acagcatgga gaaacaatca 1309141 ctggccgttt ttacgatcgg atgtttcaag accatccaga gcttttgaac atttttaatc 1309201 aaacaaacca aaagaaaaaa acacagcgaa ctgcactggc aaatgccgtt attgcagctg 1309261 cggcaaacat tgaccaatta ggaaacatca ttccggttgt caaacaaatc ggccacaagc 1309321 accgcagtat cggaattaag cctgagcact acccaatcgt cggtaaatat ttgctgattg 1309381 cgattaaaga tgtattggga gacgctgcaa ctcctgacat tatgcaggca tgggaaaaag 1309441 cgtacggagt cattgctgac gcgttcatcg gaattgaaaa agacatgtat gaacaggctg 1309501 aagagcaagc cggcggctgg aaggagtata agccattcgt tatcgcaaaa aaagagcggg 1309561 aaagcaaaga aattacatcc ttctatttga aaccggaaga cagcaagccg ttacctgaat 1309621 tccaagcagg gcaatatatc agcatcaaag tgcggattcc tgattctgaa tatacgcata 1309681 tccgccagta cagcctgtct gatatgccgg gaaaagacta ttatcgaatt tcagtgaaga 1309741 aagatggtgt cgtgtcttcc tacttacacg atgggctgca ggagggagat tcaatagaga 1309801 tcagcgcacc ggcaggggac tttgttttag atcatgcatc acaaaaagat ctcgttttga 1309861 tcagtgccgg agttggcatt acaccaatga tcagcatgct gaaaacatct gtttccaaac 1309921 agcctgaacg gcaaattctg ttcattcatg cggcgaaaaa cagtgaatat catgcattgc 1309981 gccatgaagt agaagaagca gcaaaacatt ctgctgttaa aacagcattt gtgtatcgcg 1310041 agccgacaga ggaagaccgt gcaggtgatc tgcattttca tgaaggacag attgatcagc 1310101 aattcctcaa agaactgatt gccaacacag atgcggatta ctatatttgc ggttcaccgt 1310161 cgtttattac ggcaatgcat aagcttgtat cagagctcgg atcagcgccg gagtctatcc 1310221 attacgagct attcggcccg caattaagtt tggcgcagtc cgtttgaaca catacatgaa 1310281 actcttctcc tttcagagaa gagtttttta ttgagatata agaaggcaga caagcgccgg 1310341 tttctacatc cggacaatca cagacccgct gccatttgtg catacacggt tttgctgttc 1310401 ttgcattgtt ctcagcaatt cattgtttac ctcaatcgct ctaattagtt gcttcattct 1310461 tagctccaaa ccggccagcc tgtcgattgt ttgctgctgg tagccctcgg gttggggagc 1310521 caatggcaga tcaaagggcc aaagggtatt cgacttctga tttttcatat tgcgtattgc 1310581 gcctccaatc ggtgtcactt tctattatgt tatgttcagg cgatatgcac gttcgcctag 1310641 acactgatgc atagagggcc tgccacgggg cacaataggc tcaatatgac cagcggatgg 1310701 aggtaaagat cggtgttatg gatggtatgg gtatttttac tgaagccagt tatcgtattt 1310761 tcgattgcat atattttgtt tcggcttgcc ggtaaaaaag ctgtgtcaca aatgaacaat 1310821 tttgacctgc ttttgacctt cgcaatcgga accattatca gtgagccgat ccttacatcc 1310881 aagctgccga tgtcaattta ttatgcgggt gcttttttgg tgctttatct tatcatgagc 1310941 aagctctctt tatctaataa atggcgatgg ctcctagtcg tgagcccgac tgtcctaatc 1311001 cgaaacgggg atattgatga acgcggcctt cgtaaagaaa ggctgactgt taatgagctg 1311061 ctcggaaagc tgagggaaaa gggctatgcc gacccggctg acattgatct tgctatcatt 1311121 gaagaaacgg gagaagtaag cgtcatcccg aaagaggaag cgagagcggt gcaggtgcgg 1311181 gatttgaata tggaagctga acggaatttt atcccgattc cgctcatact ggatggcgaa 1311241 atccttgatc ataatttgaa atatctccaa aaaaaccgat cctggctgtt tgagaagctt 1311301 gaggaaaaag ggtacagccc caaactgctg tcttcgatta tccttggcac gatgaatgca 1311361 cgcggtgata tatcccttga tttaaatacc gctaatgaac cgcagcatga tccttactta 1311421 tataaaccgg gaaataacaa ttaagatggc tctctcttgt aatgagagct tttttctttt 1311481 ttaaagggaa tttttgtttg gtgtcaaatg tacctagtta ggaggggaac tgaacatgaa 1311541 ggacttatcc ataagaaacg acatggcgcc aacggtcagt ttgctgtatt ccgcagtgga 1311601 agaaaacagt ctccgtctgg cttccatcgt aagccatatg acacacagtg aactttacta 1311661 taaggggcgc tgccaaacaa aaaacagcac ggctcagctt ttgcaccata tcacaaatgt 1311721 tgatatcaga tgggtctggc gtatcaagga aaatcggatc ccggaccata ttgaacaggc 1311781 atacggcccg atgacagatg aaagcggacg gctgcctgaa ccggtgaatc agccagactt 1311841 agatgaactc ctgaaaagac atcagcatgt agtagagaag ctgaaatcgg tatgcttcac 1311901 tttaactgaa aatgctttga accagccgct ttccttcgaa ggtgacaccg cgacgatacg 1311961 atggggaatt tggcatatgg cagatcataa ccgctatcat caggcacata ttgaagctct 1312021 caaaaaagaa tggaagcagg atgtggcgaa gtatgaacgc taaaacgaag cttgtgactg 1312081 atcgaattcg tttgcgctgt atggaagatc gggatcaagc cactttgttt gggctgcttt 1312141 ttaatgatcc tgacgtcatg acatattatt ccggtttaaa agataagagg caaacccgcg 1312201 agtgggtcaa ttggaaccaa cgaaatgaaa aagggtacgg cgttagtctg tggatcgccg 1312261 aagataagcg gacaggggag tttttggggc aatgcggcat cgttccccag cagatcgaaa 1312321 atcaaaccgt aatggaaatt ggctatatgt ttgcccgccg ccactggggg aacggctatg 1312381 cgcaagaagc ggctcgggcc tgtctggact atggctttaa cgagcggcag ttcggcaaaa 1312441 tggcggcttt gattgatccg ggtaacaaag cgtccatacg ggtagcggag aaaatcggca 1312501 tgcattacag caaaacgatc agaaaatgga ataaaccgat cgcggtatat gaaagaaaat 1312561 cttacaattg aaagatagag ctgagtttag tatcatgata tcatgtaaag ttttctaggg 1312621 ttccgcatgt caattgacat ggactggtcc gagagaaaac acatacgcgt aaatagaagc 1312681 gcgtatgcac acggagggaa aaaagcccgg gagagtcaat ctcatgtgag acgactgtcc 1312741 ggggtttttt tgttttcgga gaatcttaat agatagaaag gaatgactca aaatgaaatg 1312801 gggattggtc gtgcttgccg ctgttttcga ggttgtttgg gtgataggct taaagcacgc 1312861 tgactcagcc ttaacatgga gcggcactgc catcggcatc atattcagct tttaccttct 1312921 aatgaaggcg actcacagtc tgcctgttgg taccgtgtat gccgtcttta ccgggctcgg 1312981 cacagcggga acagtactta gtgaaatcgt tctttttcat gaaccggttg gatggccgaa 1313041 gctattgtta attggcgtgc tcttaatcgg tgtaatcggg ttgaagcttg tgacacagga 1313101 tgagacagag gaaaaaggag gcgaggcata atgctgcact ggatcagttt attgtgcgcg 1313161 ggctgtttag aaatggccgg cgtggccctt atgaatcaat atgcgaaaga aaaaagcgtg 1313221 aaatgggtgc tgttgatcat tgttggtttt gccgcttcat tttccttgct gtcgtacgca 1313281 atggaaacca ctccgatggg aacggcttac gcggtctgga caggaattgg caccgccggc 1313341 ggggcgctta tcggcatcct cttttacaag gagcagaaag acgccaaacg gatcttcttt 1313401 atcgcgttga ttttatgctc agcagttggt ttaaaaattc tgtcataaat tgatttttat 1313461 caaatcttca gtataatgga taaatagttt agacttacaa agataagagg gattattcat 1313521 gaaatcatat atgactcagc ggttggacga ataccgtgac ggaaatgagg ataaaggtcg 1313581 gctcttggtc agctgccccg atcagccggg tatcgtctct gcagtttccg cgtttttatt 1313641 tgaacacggt gccaatatta tagaatcaaa tcaatatacg acagaccctg aaggcggccg 1313701 gttcttcctg agaatcgaat tcgactgcgc aggcattcgt gaaaaaaaat catcacttca 1313761 ggcagcgttt gcctctgttg cggaaaaatt cgacatgaca tggagcttaa ctttggcgag 1313821 cgaactgaag cgtgtcgcca ttttcgtttc aaaggagctc cactgcctgc atgagctgat 1313881 ttgggaatgg caaaccggca acctgatggc ggagatcgct gttgtcatca gtaaccatga 1313941 ggaagcgaga gagctggttg agcgcctgaa cattccattc cactatatga aagcgaacaa 1314001 agacatcaga gcggaagtcg aaaagaagca gcttgaactg ctggagcagt acgatgttga 1314061 tgtgatcgtg ctcgcacgct atatgcagat tctaactcct gattttgttt cggctcatcc 1314121 gaatcgcatc atcaatatcc accattcatt cctgccagct tttatcggtg cgaatccgta 1314181 caaacgggcc tacgagcgcg gcgtgaaact gatcggtgcg acatctcatt atgtgacaaa 1314241 cgatcttgat gaagggccga tcattgaaca ggatattgag cgtgtggacc accgcgataa 1314301 tgcggaagcg ctgaaaaaca tcggaagaac aattgagcgc agcgtgcttg cccgtgctgt 1314361 gaaatggcat ttggaagacc gtgtcatcgt tcatgaaaat aaaacaatcg tctttaacta 1314421 gactgcaaga ggcccgcgca atgcgggcta tttttgatga caaaaaacct tgacaagtgt 1314481 cttttttctt tgcataatat aaaaaaatca ttgagcgttg aagaggatta gtaagcagac 1314541 ctttctgtga cagagagcaa aatgaatcgc tgaaacattt tgccgcatga aacctgccga 1314601 acctgccttg gagtcctagg gggaaaacct aggcgcataa cctggcgtta caggagagcg 1314661 gagcgtgcac aagcgcgttc aatcaaggtg gtaccacgga aacccatttc gtccttatga 1314721 atcaggatga aatgggtttt tttattgtag aagagccgcg gaggagaata aatgaaaaaa 1314781 caaagaatag tagtgaaaat aggaagcagt tcgctcacga atagcaaagg aagcattgat 1314841 gaggcaaaaa tcagagagca tgttcaggcg atttccgtgt taaaaaaagc ggggcatgaa 1314901 atgattctga ttacctcggg tgccgtagcg gcggggtttt ccagcctcgg ttatccatcc 1314961 cgtcccgtta ccatcaaagg aaaacaggcg gcggccgcgg tcggacaaac actgttaatg 1315021 cagcaatata tgaatcaatt taaacaatac tcactgactc cgggacaaat ccttttaacg 1315081 agaaatgatt tttcgaaaag agaacggtat cgaaacgcgt atgctacgat aatggaatta 1315141 ttagagcggg gcgtcattcc gattatcaac gagaacgatt ctacatctgt tgaagaattg 1315201 acattcggag ataatgatat gctttctgcg ttagtcagcg gattgattca cgcggaccag 1315261 ctcatgattc tcactgacat taacggactg tatgatgcca atccaaatga aaatcctgag 1315321 gcgaaacgat ttgattattt gccagagatc acgcctgaat tgcttggata tgcaggttca 1315381 gctggatcaa aggtcggcac cggcggaatg aaatcaaagc tgttagccac acaaaccgcg 1315441 ctgtctctgg gagtgaaagt attcattgga actggcagcg gagagcaaaa acttgcggac 1315501 attttggacg gcaggggaga cggcacttat atcggagaca aagaactatc ttcggttaac 1315561 aacacaaggc agtggattca gttccactcg ccgatatcgg gagaaattat cattgatgcg 1315621 ggtgccgaag aggcgatgat ccataatgga agcagccttt tgcccgctgg agttgtgggc 1315681 gtgaacggaa gctttccgaa aggggcggtt gtggaagtca ggggaccggg cggcgtgatc 1315741 ggcaaaggcc aaactcatta ctcctccgag gagattatgg aggctaaagg caaacgcagt 1315801 gacgaacttg attttgagaa aacgtttgag gttattcata ggaatgactg ggtcaatgta 1315861 aaagactagg aggcggaaaa atgagtgaag tttctgtaaa agcgaagctg gcgaaagaag 1315921 cagcagccga aatgatcatg aaaacaacag ccgagaagga tgaggcgctc agcctcattg 1315981 caaacggact ccgcaaagaa ctggattttc tcttggcgga gaatgcaaaa gacattgtga 1316041 acggaaaaga gaatggttta acaccggaca tcattgaccg tctctcattg gatgagaaac 1316101 ggatacgcga tatcgcggac gcggtggagc tcttaatcga cttagcggac ccaatcggcg 1316161 actctcttga aacgattgaa aaagaaaacg gcctgtttat tgaaaaaatc cgtgtgccgc 1316221 tcggtgtcgt aggaatgatt tatgaggcga ggccaaacgt cacagttgat gcggctaccc 1316281 tttgcctgaa gacagggaac gcggttgtgc tgcggggaag ctcctcagcc atccacagca 1316341 acaaagcgct cgtcagtgtc atttacagag cacttgagca atcagcgctt ccgattcacg 1316401 ctgtgcagct gattgaggat acgagcagag agacagcaaa agagctcttt acgttaaatg 1316461 atggcttaga cgtattgatt ccgcgcggag gcaagaaact gattgatctc gttgtgagag 1316521 aatcaacagt tcctgtatta gaaacgggag caggaaactg ccacatattc attgacgaaa 1316581 cagccaaacc gcaaatggca gaaaaggttg ttgtaaatgc caaaacgcag cgcccttctg 1316641 tatgcaacgc gattgaatca ttgctgattc acaaggcttg ggcaagacag cacggaaaag 1316701 aattgctgga ccagctggaa aacgcgggag ttgaaattcg cggtgatgaa ttggtatgtg 1316761 aacttcatcc ttcaagcaaa caagcatcaa aagaagattg ggaaaccgaa tttttagcgc 1316821 ctgtcctcag cgtaaagacg gttgaaaacg tccaagaagc tgtaaagcat atccaacaat 1316881 acggcaccaa tcattctgaa gcgattttaa ctgaaaatga caaaaatgcg gtatattttc 1316941 aaacggctgt cgatgctgcc gctgtctatc ataacgcgtc aacccgcttt accgacggct 1317001 ttgaattcgg ctacggagcc gaaatcggca tcagcacgca aaagcttcat gcaagaggac 1317061 cgatggggct tcctgcactg acttctacaa aatacatcat taaaggaact gggcaaatcc 1317121 gtgaatagcg gggtaatgtt caatgaaaaa gcttatctca ttacgagata agctttttta 1317181 tacgcgaaaa attgacattt caaatttaat tgtgtacaat ttaattgtat aaaatatatt 1317241 gggggaatga aaaatgagtc agccattatt taccgcaact gtttcagcgg taggaggaag 1317301 agaaggaaag gtcatttcat cagaccgcgt tcttgagctt gatgtcgcaa tgccggggac 1317361 accgagagcc aagaaattag aaaaagcgac aaatccagag cagctgtttg cagcaggtta 1317421 tgcagcttgc tttgacagcg ccctgcagct tgtcgcaaga acagaacggg taaaagtaga 1317481 gacagaggtt acagcaaatg ttagcctgtt aaaggatgaa gcggaccagg gctataagct 1317541 gggtgtgacg ctgcaagtaa aaggagaagg agtcagtgca tcagaattgg aggcgcttgt 1317601 gaaaaaagcg cacggcgtct gcccgtactc aaaagcaacc tccggaaata ttgatgtgac 1317661 acttgaagtt gctgaataaa taaaaagagg atgcctgtac aaggcatcct caattttttt 1317721 gatgaagtgt ttccagtaat gtatatagag cggactttaa ctgtttgaga tcctccccag 1317781 actgctttga gagccccaga attgtccctg gaatgtcaac cgctttttct tttaataacg 1317841 ctccgtcctc tgtcaggctg atcaacacgg accgctcatc ctcttcagat ctttttctcg 1317901 taatcaaacc ctgttgttcc attcgtttaa gcatcggagt gagcgttcct gaatctaaat 1317961 acagctgttc gcccattttt ttgacagtaa gcgtttcatg ttcccataac aaaagcaaag 1318021 ccaaatattg agggtatgtt atattcagct tatcaagcag cggcttgtat tgctttgtca 1318081 tctcccgcga actcgcatat agcaaaaaac aaagctgatt ctccaatttc atatgatcaa 1318141 atttattttc cattttgttc accaactctt ttttgtcatt cgattctatt gtatctgaaa 1318201 aacctcactt ttcctattct cggcaaacat agcatgttta aaaagatcag aaagggaaat 1318261 ataacaacta gatacaaata aggaggttgg gaaatatggc actatttaca gcaaaagtaa 1318321 ccgcgcgagg cggacgagca ggacatatta catcagatga cggtgttctt gattttgata 1318381 ttgtcatgcc aaatgccaaa aaagaaggac aaaccggcac aaatccggaa cagctctttg 1318441 cggcagggta tgctgcatgc ttcggcggcg cgctcgaaca cgtagccaaa gagcagaata 1318501 tcgaaattga ttcggagatt gaagggcagg tcagcctcat gaaggatgag agcgacggcg 1318561 ggtttaaaat cggtgtcaca cttgttgtga acacgaaaga tttagatcgg gaaaaggcac 1318621 aagagcttgt caacgccgct catgaattct gtccttactc aaaggcaacc agaggaaatg 1318681 ttgatgtaaa actagaatta aaataatgac cggcatcctg aggattctca ggatgttttt 1318741 tggtgtcgga catgcggggc gggcacagat ttatgataaa acttcagaga agcgtttgaa 1318801 gcatgccttt aaaccaaaag ttacagatga agcgggtggc tggcacggtg tctgccgtgc 1318861 tgaattgcgc gtatatgctg ttttgtattt gcacagggca tagcggctac ttggagaaat 1318921 aacaaggacc aggccgcgca tgcctgatcc ttttaatatt ctttcttatt ggcgaagttc 1318981 cgccatgctt gaaacgggga taaatgctct gttagtgtca cttgataaaa ggggatcgtt 1319041 ctttcttcag caggtttatc aatttcttta taaatgaatg aatcatcaaa cccggcttcg 1319101 gcagcgtctg tgtgctcagc tgcatagaaa acggctttag gccgggccca gtagatggcg 1319161 cccaagcaca ttgggcatgg ttcacagctc gtatacaaaa tgcagtcatc aagctggtag 1319221 gctcctagca ccttacaggc tttccgaata gctgtgactt ccgcgtgggc agtcggatca 1319281 ttgcttgttg tgacgttgtt ctgtccctct gcaataatgg ctccgtcttt cacgataacg 1319341 gctccaaaag gcccgccgat tcctgcattc actccttcac atgcgagagt gacagcccgt 1319401 tttaagaacg tttcatgatt catcccaatc cctcctgtca atagagtgtt attagtatag 1319461 ccgaaaagaa tgcaaagaac attcttaaaa aagtgcaaaa taaacaaagt atttggggga 1319521 tttgctaaat aagaaaccga ttgtggctgt attatagaaa aaaaccatct gccaaatgca 1319581 gatggttttt tcaaattata ctagctgtgt ctgctgtgct cttgcctgtt ttgcggcttc 1319641 aaccatattt ttcaatgctg caaccgtttc ttcctgctgt cttgttttca atccgcagtc 1319701 tggatttacc cagaagcggt cagtcggaca gacggcaagc gcatcaacga taatattgta 1319761 catttcttca gttgacggca cacgagggct gtgaatgtca tatacaccaa ggccaagccc 1319821 tttcaaatac gggtggtttt ttaagtaatc taaaaatcct ccgtggcttc tgctatgttc 1319881 gattgtaatc acatcggcat caagatcatt gattgtatca acgatatctt cgaagttgct 1319941 gtagcacata tgtgtatgaa tttgtgtctc gtttttcacg gaagaagtgg ttaatctgaa 1320001 agcttctgcc gcccaagtca aatactcatc ccaatcgcgg gttttcaatg gaaggccttc 1320061 acgcagcgct ggttcatcga cttgaatgat ttgaatgcct gcgtcttcaa gcgctttaac 1320121 ttctttgcga agggcaagcc cgatttggaa ggcgatttct ttcctcgaga tgtcgtttcg 1320181 agggaaagac cagtttaaga ttgtaaccgg gcccgtcagc attcctttca catgcttgga 1320241 agtcaatgac tgtgcgtaga ctgtgtcttt cactgtcatc ggttcaataa attcaacatc 1320301 tccgtaaatg actggcgggc ggacacagcg tgagccgtat gattgaaccc aggcatattt 1320361 agtgaaggcg aaaccggcca gcttttcacc gaagtattcg accatgtctg tccgttcaaa 1320421 ttcgccgtga acaaggacat caagctccaa ttcttcctga atatcaatcc atctttttgt 1320481 ttccgcattg ataaagtttt gatactgttc atcggaccac tcagctttcc gccatttttg 1320541 gcgtgcgctc cgcacttcag cagactgcgg gaagctgccg atcgttgtcg tcggcaaaag 1320601 cggaaggccg agagattcat tttgtagggc taaacgttct tcaaacggaa tcgggcgctt 1320661 gaagtcttta tcagttaatt gctcaagctc tttcttttgt tcagaattgg cgcctgttgc 1320721 aaactgttta agcgcctgga tatcagcctt agcctgctga atctcttcgc tgatcgccgc 1320781 ttttcctgat actaagcctt ctttcaaagc tgtcagctcg gccagctttt cttttgcgta 1320841 ggataatccg ttcaataggt ctttttccaa atgctcatca gggtgtttcg ctactggaac 1320901 atgcagcagg ctgctggaag gctgaatcca cagttcatca acttttgcaa tgctgagaat 1320961 atcaagaacg gcatcgagac gctcttcaag gtccgctttc caaatgttgc gtccgtcgat 1321021 aacgccggct gccagcactt tatctgtcgg gaagccatgt gttttaagct gttccaggtt 1321081 tctgcctttg tcgtgaacga aatcaaggcc aattccctga accgggtaag agatcagctc 1321141 ttcataagca tcaacagaat caaaatacgt ctgcaaaagc acattcaagg atgaaagctc 1321201 acttgtaatg ctttcaaata attcttttgc gccgcgtaca tcttcactag aggcggtaac 1321261 gagcgccggc tcatcgattt gaacccattt tacgccttct tcttcaagct ctttcaaaag 1321321 ctgtacatat aatggcacaa ggcgtttttg gatcgctttt gcttcagacg gttcatagcc 1321381 tttagcaagc gtaacgaacg tataagggcc gacaatcaca ggctttgttt ccacaccgta 1321441 ttcctgtttg atccggcgat aatcttcgag ttgtttgttt cttgtcagac ggaactcaat 1321501 gctctcgtca tattccggaa cgatgtaatg gtaatttgta ttaaaccatt ttgtcatttc 1321561 actagataca gcgtctttga ttccgcgggc gatagcgaag tatgtatcgg tagcgtcagt 1321621 caaatgtctg aaccgtttcg ggatccagtt gaagctgact gctgtgtcga gtacatggtc 1321681 atactgtgtg aaatcagaaa caggcacaac atcaatctgc tggtcaattt gtgtttttac 1321741 tgcggataaa aatagttcgt cgatttgctt caaaaacgta tctttatcag tactgccttt 1321801 ccaatacgct tcaagtgctt ttttccattc ccggttcagt ccgattctcg gaaatcctaa 1321861 attcgatgtt ttgatggttg tcattgtttc tcctccttta tatgtaaaac actctctttc 1321921 acccgcggat acaggctgct aagaggtttt ctcacaacaa aaagcctctt tcccatgaga 1321981 gaaagaggct tttctacgta aaacactgcc tctctcatct ctcagacaca atctgatgga 1322041 attagcaccg tgccttatga gacatcagtc tcggcgcgaa aagcagtgcg ccccatttca 1322101 caatggtatt acggtcggtt gctgttgggg tcaaaaggcc aatccctcgc ccaactctcg 1322161 ataagagaaa atgttattaa ttttttgaaa agttgaatca tttgttggta atcttaacag 1322221 taattcaaat tcattgtcaa catagaattt gaaattttta tttacatgat gtggtgtata 1322281 ttatataaga aaaataatct tatagggtca acaaatgtga ttgctctgct ttttctgcga 1322341 gctcatcagg agctgttaaa tacaggaatc cattgcctgc cagcgttttt gcaatatcaa 1322401 gaggaagtgt cctgcggatt agctgtgcga aaacctcaga ttcagaaagc tttctttgaa 1322461 atgattcttc ttcatagctt ttgattaaag caagcgcacc gctgacatga ggggcagcca 1322521 ttgaagtgcc ggtcagctta ccgtacttct tgttgggaag ggtggataag atgttttctc 1322581 ctggtgccac aaggtcaatc tctttattcg cgttagaaaa ttctgataat tctcgcgcta 1322641 cagaaacaga tccaactgca atcacttcat tataagctgc ggggtaggaa agctcttctg 1322701 tgcgttcgtc gccgtcacct tcatttcccg ctgcacaaac gacaagcact ccgtttttca 1322761 ctgcgttttt cactgcttct tttagctctg gcacatcgct tggccctcca agggacattg 1322821 agatgatgtc gactttctgt tccaccgcgt agttgatgcc gttaattatc cattcgtatt 1322881 gtccgctgcc gttctcgccg ccaagaacct tcacaatcaa taggcttgcc tcaggcgcga 1322941 ctccggcaat gcctccgttt gaatcattag ctgcaattgt tccggcgacg tgtgtgccgt 1323001 gtccgttgta gtcggaaatc gcatcttcct tgccgccgtc gtcatccgtg aagttctttc 1323061 cgccgatgat ttgatttttt aaatcagggt ggcttgtgtc gcagcctgtg tctaatacag 1323121 caactttaat atttttgcct tttacccctt ttgcccacat ttctggcgcc ttaatcactt 1323181 taatgccctc aggaagctcg tttacatcca tgatctgctc attcgtcaca tacgggatca 1323241 agcggatttc accattcata aaaaagccct ccttttttat gcttgcaagt ggattcaagg 1323301 gtgttgcctc atattatatg aaaaaagcaa gcgctcggac agagccattt gaagcatttt 1323361 gaaaaaatag gatacacacc aaagaattag taatcttcaa aatattggat ggcttcaaca 1323421 tgtatgactg ggattcaact gtaagtcaag ttataatagt gttggggaaa ggagcagtgt 1323481 catgaaactg aatgaaaaat tatatgcatt tttttcagag catgtggaac aaatggccga 1323541 ggaatggatt gaaacgatgg aggaaagtga tccgaattcg ctttacgccc tacataatgc 1323601 aacagtaacg gaagaattga aagagcagga cagagaattt taccggcatc tgaattacat 1323661 gtatgtttta ccggaaaaac aatttctcga agagtttcaa gagtgggtca ttgagctgac 1323721 caacgatcaa aaacatctcg acacaccggt tcagtatgtc attcgggagt ttatgagaaa 1323781 caggagatta tatacgaagt attttgagaa gttcgcagaa gaaaatgaat cagcgtttga 1323841 accgggagag aagcaaaaat gggcagattt gattgtaaaa gtatttgatt tcaccattta 1323901 tacattcgtt gatcacgctg aaatgaatgc caagcagcaa ttaaacgccc aaagagaaat 1323961 gatattggaa ttaagctcac ctgtcattac cctgagcaaa tcaacagctc tgctgccgct 1324021 tgtcggtgac attgataccg aacgggcgaa gtttattctg gaaaacacgc ttcaagcttg 1324081 tgcgaaaaga cgtgtggagc atctgttaat cgatctgtca ggtgttgttg tggtggatac 1324141 gatggtggcg caccagatct ttaaattgat tgaggcgctt aatctgatcg gtgtccggtc 1324201 aaccctgtca ggaatcaggc ctgaaattgc gcaaactgct gtacagctgg ggattgactt 1324261 ttcgaatatt actattaaaa ccaaccttgc ccaagcatta aactatcatc aataaaaaaa 1324321 tccgctatct gtgatagcgg attttttatg atgcgaaaca taaagatacg agaaaggatc 1324381 ccgcgaataa taagaggacg aggcaaaaga acacccagtc gcgccggttc acgctcaatg 1324441 tcctgtagta tgtccggttt ctgcttcctg taaatccttt cgattccatc gcaagcgctg 1324501 tccgttccgc ttttctgatg gcgcttgcca atagcggtat ggtatatcgt tttaacgcac 1324561 tgattttatt aatgatgccg ctctccgccg ctcctcctct gattttatga gcctgctgaa 1324621 tcagctggac ctcatccttt aacagcggaa gaaagcgaaa gcctgcaatg acaccgtacg 1324681 cgagctttgg tgagagcctg cactgctgga caaggctcag cataaataga atcggatcgg 1324741 ttgtaaaaac aaacatcatc gataaggcgg aaaagcataa aatacgaaac ccgagagaga 1324801 tgccgacaga cacattatcg ctgttaatgg agatagggcc tgcttgaaac aaaaaattat 1324861 ccggtgttgt cggcactttt ccaaaaactg cggctgtcca cacgcatccg aatgctaaaa 1324921 tcaaaaacgg aatcgtaaac aacaaccatt ttttcaatgg gattccggcc gccagtaaaa 1324981 cgcccgcaac gatgatgata taaaaacatg ccggagtgta agggttgtaa ataaacgaca 1325041 gcatgacgac acaacaaaaa accgccgccg ctttcacagt cggattaatg agatgtaacg 1325101 gttgcttcat cacgcacctc ctcttgaaat gccatccatt catatagaag gggaagggtg 1325161 agctttgctt tttgaacaag ccctgtttct tgagaaaaca actgcgctgg agatccgtca 1325221 aaggccaggc ctgtatcgtg aagcacaagc acgctgtcag catacgaaga gactagctcc 1325281 atatcgtgtg taatcataag gacagcagtt ccctctgcct tgatacgttg aatcatttcc 1325341 atgcattcag ccgccgtgcg ggcatcctgg ccaaaggttg gttcgtctaa taataaaacc 1325401 tttacgtcat gcatgagcat agtagctacg ctcagtcgcc gtttttgccc ttggctgatc 1325461 gcaaacggat gatgatcagc caaatgcgca agaccaaaac gctgcagcag gtgttgcgct 1325521 tttttctcag tttcagcatt tgctttctgg ccgaacagaa gctcgtcata caccgtatcg 1325581 gtgacgaatt gatgctcagg gttttgaaaa acaaatccca tccgtttacg caattctttt 1325641 tctttatatt tctgcagcgg ctgatcatag agaaggattt tgccgctttg cggtttcatg 1325701 agactggcca gaactgatag gagcgtcgat tttccagttc cgttcggacc gacaagcgcc 1325761 gttaaagagc cttcgcgcaa cgaaaagctg atgtctttga aaatcgcctg ctgtcctctc 1325821 gcgaacgaaa ggctgctgac ttcaagcaca ctctccccag aaggggcttt cttctttttg 1325881 acatgcccgg caggaatagg ctctttgaac agcatctctt ttgataaagt aaacggcata 1325941 ctcagctttt cctgcagatg acagaccttt ggaatggcga tgcccaattt ctttagtgtc 1326001 tccgcttcat gctgaaatag atttttcgtc aggccatcca gtgccttttt gcctgatttg 1326061 tcgagtacga tcgttctctc aatccaaggc gcccattcat caagctggtg ctcaatgacg 1326121 aggaggctga aacctttttc ccgctgaaga tccttcatca gatgaacgaa ctcccgagct 1326181 gagaaagggt ctaaaagaga ggtcggctca tctaaaataa taagctcagg ctccatcgcc 1326241 aaaatacagg cgagagccac tttctgcttt tgtcctcctg aaagggttga gatcattttt 1326301 tcttttaaat gggtaatgcg taatttttct aatacggcgt tgattttctc tgtcatttct 1326361 tcttttggaa tttgcagatt ttccagcccg aacgctattt cgtcctccac cgtcagcatg 1326421 cagaactgct gatcaggatc ctgaaaaacg accccggcat gctgagtaat cgtttcggag 1326481 gtttcagcat ctgtgaccgg cttttgaaat agaaatacat gtccggactg aatgccgtcg 1326541 caagcctccg gatatagacc gtttaaacaa agggcgagcg agcttttacc gcatccgctc 1326601 ggtcctaata ataaaacaca ttctcctttt tgaagctcaa acgaaatgtc ttgaaaaacc 1326661 ggtttctcgt cttcttcata agagaagctg agctgctcaa ccgtcagaag ctcatcaaag 1326721 gcttgcatgt tctgacgccc gcttccgttt ctttttcagt tcctttccga gtgccattcc 1326781 gtttaacaca cctgtataag cgagagagtc gctgacagct tttccgagaa gccccgccaa 1326841 aagcgcgccg gaaatgaggc ggatcacaag cataatgagc agataacctg gtgaataggc 1326901 tgcatagcca gaaacaaaga gatcatagat aaagctggct actgaagacc ccataccggc 1326961 cagcataagg acagggagag agtatgcttt ccagcgtgtt gcaagaaata cagcctcagc 1327021 cccgagccct tgaacaatgc caatgacgat gaccatcggg ccagacggat ttcccagcag 1327081 gcactcaacg agagcggcaa tgatttcaga aacgagcgcc gcacccggtt ttcgaatcat 1327141 gtacgcggcg atcacagaaa cgataaacca aatgccgtaa attggttcat aggcgattgg 1327201 cccaaacata cctgcaagta cgtttccgaa atgtgtaaat aataaataaa caacggcaaa 1327261 tacgatactg ataacggaca tgatgacaat ttcttttact ttccagcttt tcatgttatc 1327321 cctgctttct gttttttctt gatggactgt tagccgaaag attcacagtc atggtgatgt 1327381 ggtttgtttg ctgctcagcc atgcggaaaa cggcctccaa tgtgctgaat acgtcatgcg 1327441 catccccgtc aagctcgctc gcgtaatgga caccctgtac gaaagtgcct tgggcttttg 1327501 caatgtcgac agcctccata atcaatccca tataatccgg ctcattcatt ggataaaggg 1327561 caaattggca cggcgcttcc gccttcaagc ctcggacagc atcttcattg acacgcttat 1327621 cacctttgga aagatatgta tccccctgtg tgtcacccgg gcatccaatg gaaaacgtgc 1327681 cgttcatgac gatgtgttgt tcgctgtttg ctgcatgaag gtaaatggct tttgcagcat 1327741 cgaatacatg atcaatcgat ccgcgtaaca ccgtgctgat atggtcggtt ttcgtccaaa 1327801 ccttggatgt atctgttttt ttcagcgcag acttgatcac actgataaaa tcatccgtca 1327861 tcggatataa agagaagcga aaaccggcga ttctgcttgt accgcaaata tgctccattt 1327921 ctccgacctc ctgttttttt ggtaaaataa aaaactgcat atcctaaggg aatatgcagt 1327981 catagatcga ttaagcgcac aaaaaaatac accattcggt caacctgcac ttccccacgc 1328041 tggtattatc cagatcgggt cataagggat caaagcgcgt ttcttccgcg ctttatctca 1328101 gccaaaacag cacccctagt gctttccgta tacaattttt tattttgaca tcataataga 1328161 tgataagaat cattttgtaa acaacgaaat catttttttc atatagggac gggagaggat 1328221 ggtcaaattt ggaaaaagga cacatattaa ttgtggaaga tgaagaaaaa atcgccaggg 1328281 ttcttcagct tgaattggaa tatgaaggat acagcgtcac gatcaaacac aatggcacag 1328341 aaggtcttga tgcggcagcg gaaggcgggt attccttggt gcttcttgat gtcatgcttc 1328401 cggggcttag cggactggaa gtgctgcgcc gcttgagaaa aacggattcg cagacaccgg 1328461 tcatattatt aacggcgcga gacagtattc ctgataaggt aacaggtctg gacatcggtg 1328521 caaatgacta tgtcaccaag ccgtttgaaa tcgaggaatt gcttgcgaga atcagggcgg 1328581 cgctgcggca aaatggaaca aaaactgaag atatcggcac ctttcttaca tatgacgatt 1328641 tgcgggtgaa cgaaaaaacc cgtgaagtga gacgcggaga caaagaggtg gaattaacgc 1328701 cgcgggaatt tgatctgctc gtctatatgc taaagcatcc gcagcaagtg ctgacacggg 1328761 agcaaattct aagctcagta tggggatttg attatatcgg tgatacaaat gtcgtggacg 1328821 tctacataag atacatcaga aaaaaactgg actatcctta cgaaaaacag ctgatccata 1328881 cgattcgcgg ggtcggctat gccattaagg ggtaaacgat gaagctgaag accaagattc 1328941 atctatacac ttcgatatca ctgttgattt tattaatttt ggttcatacc gcagtatatc 1329001 tcattttttc gtctgcgctg acatcaaagg atgcggcccg gcttgctgat gagacggata 1329061 acattgccga agcgctgcgt gccgctgaaa cagaaggagt ggctttgcag gatatgctgc 1329121 aggcctatct tccggcaaat ggcatggtgc gtgtagtgaa tggtgatcaa aaagccgtta 1329181 tgacgatcac aaaagaaaaa gcctataaag attttcctct ctcttttcat agcggcgaaa 1329241 cggcagatgt gaggaaacct gacggcaagc tgtttgccga ggctgctgtt ccggtgattt 1329301 ggaccgatgg acaagtcgtg tctcttcagc tggttgaaag actggagaac acagaagaga 1329361 gtctgtttct gctgaaaatc atcttaatcg ctgcaagtgc tgctgtctgc attgcttctt 1329421 tttttgcagg cagcttgcta gcccgccgaa tcatcaatcc gatcagacga ttaatgatca 1329481 caatgaaaga catacagcga gacaaagaat ttaaaacgat ttctttagaa ggacagtcca 1329541 acgatgaatt gtatcaaatg gggctgacat ttaatgaaat ggcaatgatg ctgaaggagc 1329601 actatgataa acagcagcaa tttgttcaag atgcttcaca cgaattgaaa accccgctca 1329661 ctattataga aagctacagc agcctgatga agcggtgggg tgcaaaaaag ccggaggtgc 1329721 ttgaggagtc gatagaagcc attcactcag aagcggtgca tatgaaaaaa ctgaccaatc 1329781 agcttttggc gctggccaaa agccatcaag gactcgaggt tgatctgaaa acaatcgatc 1329841 tgattaaagc ggcgcgcgcg gttatgcaaa cgctccagtc cgtttatcag cgtgacatat 1329901 tgcttgaaac agataaagag agcctgcttg taaaggcaga tgaagaacgc atcaagcagc 1329961 tgttgaccat tttgcttgat aatgcaataa agtatagtga aaagcctatt gagatgtcag 1330021 ccggaacgag gaatggacgg ccatttctat cagtgaggga tgaaggcatc ggaatacctg 1330081 aggagcatat cccgcatttg ttcgaacggt tctaccgggc agatgaggca cgaaacagaa 1330141 aaacaggcgg aacaggttta ggcctttcca ttgccaagca aatcgctgat gagcatggca 1330201 ttgagctgtc tgtcaaaagc aagccgggac aaggaacagc tgtcaccatg caattcagcg 1330261 aacagaatgg gggaggccga tgactaaaac aataaaaaca gtatcttttg ctgcagcagc 1330321 cattttagtt gtcatcatct gtacgtttct catcattcgg caaacccatg agaacgtatt 1330381 gtcaaaggag actgtcgtaa aaaaagtcga agcctcttat gaaggcaagg tcacgaaagc 1330441 aacacaatca aaggataaaa aaacatatga tataaccctt gaaaatccaa agggaactta 1330501 ctttgtaaaa gcagacgcaa tatcggctga cattctttca atgaatagag taaaagcagt 1330561 gaatccatct gccatgacag aaaaagaagc cgagcatctc gcgcttgagc gggtgccggg 1330621 aacggtcaaa aaacaaacac ggcaaagtca agttgccact tataccatac aaaaagaaga 1330681 cgggaaaaca tacgaagtga aggtagacat gcaggcaaaa acagtcttgt ctgccgatca 1330741 aatcagcagc aaagatcaac aaaaaacgcc gattacgaaa aaagaagcca aaacaattgc 1330801 agagcgaaaa acgggcggaa cagcggatga cgcagatctc gaagaaagtg agggcactct 1330861 catctttgaa gtagacgttg atcttcctga taataaggaa gcgacagtga aaatcaatgc 1330921 ctacacagga aaggtagcta acattgtgta tgaagactga cggtttctca tcaaattctc 1330981 atcttgctct cgttttcctt tcatgttgag tatgtaaact gtactcatac aaaacaaagg 1331041 agggctcaca aatgctcaag aaaaaatgga tggtcggtct tttagcaggg tgcctagcgg 1331101 ccggaggatt cagctacaac gcgtttgcca cagaaaacaa tgaaaacaga caggcttctt 1331161 ctaagacgga tgcactcact gaacaagaag cagaagcaat tgctaaaaca gttgttgacg 1331221 gcacagtaga agacattgac agagaccttt acaacggcaa agaagtctat gaagtggaga 1331281 ttgaaaaaga aggtgaagac tacgacgttt atgtagatat tcatacaaaa caagcgctta 1331341 atgacccgtt aaaggagaaa gcagaacaag tcgccataac caaagaagaa gctgaagaaa 1331401 ttgctttaaa gcaaacaggt ggaaccgtaa cagaaagtaa gcttgacgaa gatgacggtg 1331461 cttacatcta tgaaatggaa atccaaacga agcaaggaac tgagacagaa tttgaaattt 1331521 ccgcaaaaga tggacgcatt atcaaacagg agatagatga ctaatcaaaa cccccgctgc 1331581 agcgggggtt tttcatgata agaaaccttc ttttggacaa tctaagtaga aaaggaggcg 1331641 aaacgcatgg aaaagaaaga ggagcaatac atcaatcagg ctgaatatgt ccctcatccg 1331701 acgaaggaag gagagtatgc cttatttctt catgaaacgt atcatttgct ttctgaagat 1331761 gacgagacac aaacaacaga ataagggctt aggcccttgt tttgttccgt aattgtgatg 1331821 taagcgcatt tattactttt ttgagttgac atagcttgtt tttttctgta atctcagtgt 1331881 gtcaattcaa ttaggaactt cgttaggtga ggctcctgta tggagatacg ctgctgccca 1331941 aaaatgtcca aagacgccaa tgggtcaaca gaaatcatcg acataaggtg atttttaatg 1332001 cagctggatg cttgtcctat gccatacagt gctaaagctc tacgattgaa ggcgcccgca 1332061 cgcttttttt gccgtgcttc tttcaccttc aatcccgaag gcttttttta tgcctttaaa 1332121 acgaaaccaa tcaaaggagg tgcggagtat ggattctccc cattcgagtc aatctgaaga 1332181 agtacccata tactatgaca gcaagacaat tgattacacg atgaggagac gaactgccgc 1332241 accttctggc gaggccggca cgtctccgta gaggaggtac gagtcccgat ggttcaaaac 1332301 atgacctatg acgaactcat tttacgcatc attattttac tgcgagacgg gaaaatcagg 1332361 gattttagaa gtgttattga tgagcttcag ccctatgaca tggcatttat ttttaaagaa 1332421 atgccggaaa aacatcgcgc ccgctattta tcttatttaa ctgtagacga tatcactgat 1332481 atgatcgggg agctggaacg cgaatttcag cttgtcgtct taaataaagt cggaaaaaca 1332541 aaagcaacac tggcgatgaa caaaatggac aacgatgacc tcgctcaatt gcttgaagaa 1332601 atggacgaag aactgaagga acagctttta tccagcatgg aagcgtcaga atcaaaagct 1332661 gtacagctct tgatgaatta cccggctgat tcagcgggac gcatgatgac aaaccggtat 1332721 gtgtggatcc ctcagcatta cacggtaaaa gacgcggtcg tcaaactgaa aagcttcgct 1332781 gaaatagctg aatcgatcaa ctacttatat gttattaatg aaagcaaaca gctggttggg 1332841 gttctttcct accgcgattt gattctgggt gaacctgaag aaaaggtgca ggatttaatg 1332901 tttacccgcg tcatatcagc agatgctctt caggaccagg aagaagttgc ccgcctgata 1332961 gaacgttacg attttttggc aataccggtt gtagaagaaa acaacgtgct tgtcggcatt 1333021 gtgacggttg atgatattat cgacgttgtt attcgggaag ctgatgagga ttacgaaaaa 1333081 tttgccgctt ccggtaaaga catcaccttt gacacaaaag cttacgtggc ggcataccgg 1333141 cgtctgccat ggctgatttt actcttattt atcggactga tttcaggaag cattatcagc 1333201 tattttgaag acgcgctgaa gcaggttgtc gcgcttgcgt ttttcatgcc gatggtgtca 1333261 gggatgacag gaaatacggg aacacaatct cttgcggttg tcatcagagg tttgtctaaa 1333321 gaagaaatga acaaaaaaac gattgtgcgc ctgatcttcc gggagttcag aacaagcatt 1333381 tttatcggag cggtttgttc tgtgctgatt gcgattgttt ctatcatatg gcaggggaat 1333441 gcgcttttgg gatttgttgt cgcctcttca ctgttcttaa ccttaatcat cggcacgatg 1333501 tcaggaacga ttatccctat tattttgcac aaactgaaag tagacccggc gattgcttct 1333561 ggaccgctga ttacaacgtt aaacgatatt ttatctttat taatctactt tggcattgcc 1333621 actgcattca ttcactcatt ataaacgtaa aaagtccgtc tcaactgcga gccggacttt 1333681 tattatttaa cggtttttgt accgaaagtg agcattaagc tgcccctcca gcattttttt 1333741 ccgcacttgc ggatcgtttt ttaacatctg ttcttttttg cgcatatcct ttaaaatctc 1333801 tgccgtctgt acgccgtctt cacgcttatt ggcgatatcc atcagccgct ccacatcggc 1333861 aaaggagtat tttcttgtcc cccttgaaga acgctgcggg taaatgagct ttcgttcctc 1333921 ataatacctg atctgtctta cggacaatcc tgtcaattca ctcacaattc cgattgaaat 1333981 cacttttttg tctttataag aatgatcttc tgtggtcatt tttccacccc tggatgtctt 1334041 ttgataatag tatataaaaa acaaagagaa aaaacctgac gcttgtcata ttttctaaca 1334101 tcaaatagaa gatttttgaa aaaatacgga agaaaaatta acaagaataa tgcgtaacac 1334161 ccaagcgcgt tttatccttt atgtaacgaa tcaaacgagg aggaaggata atcatggagg 1334221 aagaaaaagc agtctcactg gcaaaagaaa ttatagagtt ggatatcaag cgtgatgaaa 1334281 tgctggagac gtttatgcag cttgccggag aacaggcttt tcaattatta agatcggttc 1334341 aaaacggaca ataccgaaaa tcttcgtaaa cataaattct ttacattaga ttcataccac 1334401 gttcatttaa aaagagtatc ttttgtatag gatacctcaa aatgaaggag gacgctatga 1334461 gtaatttatt gaaatccgct ttagaaaaag aacgacgcca ttattctgaa aaactctatc 1334521 agataggggt ttataataaa gaggtcatga acaaaatgac gatttctgag cttcggaaag 1334581 aatacgctta tttctttcga agcattacaa atcataaaaa ttatccttat acaagataat 1334641 gtataaggat ttttttgctt ttagaaggaa tttctcgaat tatagcgaat acgtatagta 1334701 agggactgaa ctcttattat atgtaagggt tttcattatt tttttataaa aatcctatat 1334761 acgaggtaga tatgatgaga ttatcgttta acgaagaaga agttgagcgt gcgatgaatt 1334821 tgtacagagt ttttgcaagg gctttcaaaa gtgtgtccga acatagtatc cgtgatagca 1334881 aagagcacgg ttttaatccc actgaatttg ctgtactgga actcctgtac acaagaggcc 1334941 cgcaaaaatt acagcaaatt gggtcgagac ttctgcttgt aagcggaaac gtcacatatg 1335001 ttattgacaa actagaaaga aacgggtttt tagtaaggga gcaggacccg aaagataaac 1335061 gctctgttta cgcacattta actgacaagg gaaatgagta tttggataaa atttatccga 1335121 ttcatgcact gcgtattgcg agagcgtttt caggtctttc gcctgatgaa caggaccagc 1335181 tgatcgtcct gctcaagaaa gcaggcatac acagccagca tttgctgttt cgttaactat 1335241 tctacactct ctatttcagg agagtgtttt tttgtttcca tatgattctt tttaaaacat 1335301 ctttaatctt cctatcagac atttcgccaa ggtatccatt gacgtgtttt ttatactcct 1335361 tcatctgttc gttcgattga aaaaatgccg cgatatactc ttctgctttc tgcatgtccc 1335421 agtttctcat atctgtgacg agtttccttt catgtagaag gtttaaattc atttcctcct 1335481 gtcccggcag tgcatgataa ataaataccg gaagccgttt ctgtaagcat tcactgatgg 1335541 tcacgcctcc gggtttagtc atgatgcctg tcgcctgttc gtacaaacgg ttcatctctg 1335601 ctttgctgtg aaggtaagga atcgcctcaa tcaaggggtg gtgtaaactt ttgacatagg 1335661 agtagagctt ttcgtttctg ccgcataata ttttgtataa gatctttccg cctggcgaca 1335721 gttcctgcac ccattttaaa atcccaccga cccccatact gccccctgtg atgatgatgg 1335781 tatatggcgg gtggtgctgc aaggtatctg ctgattccat ttcaaaattt tggtgaactg 1335841 gaatgccggt caagtatatg ttgttctgat cgataccctc tgatattagc tgcttcttta 1335901 cttccgtgct cggaacaaaa tggtaatcaa tgttcttccg tccccataat tgattcacga 1335961 aaaaatcagt gtatacattc acaaccgtca gattcggata ttcaggcttt agtcggttca 1336021 gcagataaga aggcagcgca tgtgtgcaga aggcgatatc aggctgtttt tcttggagga 1336081 tgtgcctcat ttgctgtgtg aacagccatt cgtacatgaa atagcgtttg tcatgctgaa 1336141 attctccgca ggcgaggagc ctgtaaatgc cgctgtacgt tttcgggaaa tattgaatcc 1336201 attttaaata agccacggag gacaattttt ctaaccgcct atacgaatgt gaaaagatat 1336261 caatcttttc agctgccagc ccttgagact ctaattcagc ctgcaatgca tcagccacat 1336321 gatgatggcc ggtggaaatg cttaaaaaag gaaaaatgag aatgtttttc atgacagtcc 1336381 tcctaaaaaa atatggcaac tatattttga ggagaacgtt cacaaaatat aagggtgttt 1336441 ttgatcataa ggaaggtgaa aagatgaaaa cttgtttcct ttccatatgg agagtggttg 1336501 atccgattta tttctttttt tcaaggctaa gcttgattga caacgatcaa aaaagcgttt 1336561 ttcgagtcag gctgacgaag tacaaaggac atcatgtcgt gcttagcgac ggaacgcata 1336621 taagaaaaaa tgatgtgctc gttaaaatcc acctgcataa cataaagctg atcagggagc 1336681 tgcaaagcat tgagagcgca gtcagaaagg gaatcattat ttatcagaaa gtatatcaat 1336741 cgatgccgct tcttcttgac tatatcaaca atcataaaaa aagcgagaaa atcaaaggaa 1336801 tcattgggat tacaatgctt gacaaaggtg tggaaaggct cggctttgat gtgatcaccc 1336861 cggtgaaccc tttttacaga tgctttaaaa aagtgtctca tgtgccgatt ttatatttga 1336921 cttcaaagcc tgtgagcttg cggcatttac cgaattcatc ctatttgttt atctcaaaag 1336981 aaaagctgca gaaaacctat caaaaaaaag actgatgcct cggtcagcac agtctttttt 1337041 gattaaatct gatgaaatgt cacttcaggg cggcttccga cacggatatt tacgccggtt 1337101 tgtcccaagc cctcgctgat ataaaatggt ttatcgtgat gataatgaag gcctttaatc 1337161 atgttcattc gcacgagctt tcccattttc accaaatgat acggttttgg ccagtgaatt 1337221 tgcccgccgt gaaaatgccc tgacagcagg taatcataat gaacatcttt catatccaga 1337281 ataatatttg ggtcatgtgt taagacaaga tgatagccat tttccagact ttgataagag 1337341 ccggtgatat tactccgatt cgtactgtaa tcatcaatgc cgataatatt gactggtcct 1337401 gcagccgtct cgattcgaac atgttcattt tgcagcgtga tacagccgtt ttcctctaaa 1337461 actcgcttca atctctgaaa gtcctcttct ttcaatacat aatcgtggtt accgaacacc 1337521 gcgtacattc catatgcagg ctttagcttt tgcaaggcgt tcaagtaacc tgccagtttc 1337581 ggaatattac gtttccgatc aagaaaatcc ccggtaagag caatgatgtc cacaggctga 1337641 tcttttgtta aatgatacag ctcctcaggt gagactgaaa tgttttccaa gtgaagatca 1337701 gataaatgaa ggatatttaa tttttttctg gctggaaggc cgtctttttg gtcgattgaa 1337761 atggtgttga ctttcacatc ttttgtattg cggttcgctt tatatagaaa tggcacaaat 1337821 acgagtatgg ccaatgaaag taagattgta aacaaaatat atcccctccc ttctatcagt 1337881 atagtaagtg atcaagccct atggatagcg ggaattaatg ggtagagaca ggttgaaaaa 1337941 cggattgtca tatgatgaat gatttggaag ggaaaaggga taataaattt tgacacatga 1338001 ggcagaacat gccgacggag tcagaataac aaatggatgt gtaagcaatg ttacgattga 1338061 tgagacaaca aaaaaaagaa acatattatc tctggatcgc attatttctt cttttattgt 1338121 atgtatcccc gctttttatt ttaaaggaag atgcccatat ccgggtccac gataatttag 1338181 attccaacat cgcttggtac aaggttctgg ccgatagcgg agaaatcgtc ggcaaggttg 1338241 acgctgccat tccgcaaatc attaacgggc tgccccggga tgcctttggc accgagtgga 1338301 gcggaattgt ttggctccat gctttctttt cttccatgac cgcctatgca ataagccaga 1338361 cggttacaag agttgtcgct ttttttggaa tgtatgtgct gctgaagaaa catataatcc 1338421 cggaaccaaa agcggctttc atccgaattg gcgtatcgct tgcatttgcc ttaacaccgt 1338481 tctggccttc gggaatgctg agtacgcttg ggtacccttt ggcactgtgg gcttttttaa 1338541 atatccgaaa aggggatatc tcatggagag agtggctgac gctgggcttg ctccctctat 1338601 actcaagctt tgttctaggc ttcttctttt tcctggcagg gatggcgtgt ttttggctgt 1338661 atgatgccat tacaaaaaga agatggaatt tgatgttctt aggcagtatt gcatttatga 1338721 cgagtatcta tcttttcgtt gaatatcggc ttgtctattc gatgctgttt gagcacgcac 1338781 cgatgcatcg tatcgaattt atctcatcta ggcatgacgt ttggcattct cttcgactat 1338841 ccataaaaaa ctttgtctat ggccataatc atgtgatgac cgttcatacc gttgtcatcc 1338901 ttccgatcct gatggtcgta tttgctgctc tgctgttcaa acgaaatcgg acaaagccag 1338961 aaaatgttta tctgttttta tgtgtgctta attacgggtt gtcattatgg tatgcgtttt 1339021 ggttcaacaa aatttgggct gttccaaagc agaaatttgc ttttttagca gaatttaatt 1339081 ttgcccgttt tcattttctt cggccgcttg ttatatacgt gagctttgcg cttgctttat 1339141 atctcatttg gcggatgggg aaaggatgga aatggcttgt gtacgccgca gtcgctgcac 1339201 agctgatggt gttggcgcct tttaatgaag aatatacgta tggtgttcat tacaacgcgc 1339261 cgacattcag ggagttttat gcatcagagc aattcaaaga gattaaggaa tatatcggac 1339321 gtccgcaaga ttcgtatagg gtggcgagca tcggactgca tccgtctatc gcccaatata 1339381 acgggtttta tacgttagat acgtataaca atctgtatcc gctctcatat aaatatgaat 1339441 ttagaaaaat catcgaaaaa gagctggaaa aaaattctcg gctgaaacaa tactttgatg 1339501 aatggggcag ccgctgctac ctttttgtcg atgaactcgg taaacgatat gatttcaaaa 1339561 agaactcgaa gaaaacgatc aacaaccttc aattaaatac agatgtattt aaaaaaatgg 1339621 gtggacggta cattttttct tcagttccga tcatgaatgc tgaacaaaac catctcgcgc 1339681 tcgtaaagac gtttgaccat aaagattccg cctggcgcat ttatttatat gaaacaagat 1339741 aaggaggata tcgattgaaa cagtcacagc cagtattaac catcgtcgtc ccgtgtttca 1339801 atgaagagga agtgtttcaa gaaacaagcc atcagctgac agaggttgta gatgatttaa 1339861 ttgaagaaaa attaattgct gaagacagta aaattctgtt tgtcgatgat ggcagcaaag 1339921 accgcacttg ggctttgatt gctatggaga gcataagaaa caagaaggtt accggcttaa 1339981 aattagcctg caatgtcggc caccaaaaag cgcttttagc cggattgcat aaagcgaaga 1340041 ataggtcaga ctgcgtcatt tcgatcgatg ctgatcttca ggacgacatc tctgtgatcc 1340101 gggattttat gctgaaatat catgagggct gcgagatcgt ttacggtgta cgccggagca 1340161 gaaaaaccga tacctttttc aagcgcacga ccgcgttagg gttttatcgt ctcatgaata 1340221 aacttgggat taaattaatt tataatcatg ctgattttcg tttaatgaat aaaaggtccc 1340281 ttgaagagct tgagcgttat ccggaagcga atctgttttt aagaggtatt gtccccatga 1340341 tcggctttaa atcggccgaa gttttgtatg accgcaagga acgctttgcc ggcaaaacga 1340401 aatatccgct gaaaaagatg ctatccttcg cttttaacgg gattacttca ttcagtgtcg 1340461 caccaattcg attctttacg cttttagggt ttgttttgtt tttcctcagc gctgtggcag 1340521 ggattggcgc gtttattcaa aagctgctcg gccatacgaa tgcaggctgg gcgtctctta 1340581 tcatatccat ttggtttttg ggcgggctgc aattgatggg aattggaatc atcggagagt 1340641 atattggaac gattttttct gaagtgaaaa gacggccgaa atacgcgatt gatattgatt 1340701 tgtataatga acagctgagc ccgcttcagc gccaggaaaa agagcggtta gaaaaaaagt 1340761 acagttaaac acggaaagag ctgacttcat tagtcagctc tttttcttca actgatgcaa 1340821 tatagcgcta agcggttcgt cttgcgggtt gcggtaaaaa tcaaaaaatg ggcagccctg 1340881 cttcttaatt cgatcgatga ccgtatcaat tgtaaacaga gcgggtgtta aagatgattg 1340941 cacctcatgc cagtagagcg gggctgcaac agtcccaagc tcatttcctc tcgttgaata 1341001 gggacagata atcgtttttc cttctgcatg ctgcaaataa tcaagataca atttgcagtg 1341061 tctgttttta atcaagcgtt cagtggtaaa gagctcggga aatgcattgg tgcagtactc 1341121 tgcgatcagc tgcgtaaatt ggcgtgtttc ttcatacgta aatgcctcgg gagacaaggg 1341181 aatataaagc tggatgcctt tgttgccgga cagcttcggg tacgatgtga tgccaaagga 1341241 atccaacagc cgcttcagtt catttgcggc ctgcacggcc ataagaaagt catctcgcga 1341301 aggcgggtct aaatcaatga caatctcagc cggacgcctg cttttaatgg tttgaaaagg 1341361 aacgtgaaac tccaaagcaa gctggttgca aagccatagc aatgtagaca tatcctcaca 1341421 gacaatatgt tcatggcttc catcatagaa agactgaaca aaatccggcg catagtccgg 1341481 cttgtttttt tggaaaaatg attcgctcct agatccatgc ggatagcgga tgacggtgac 1341541 agcccggttt ttcagaaatg ggagcaggta gtcactgact tcaatcatat actgaataaa 1341601 atcttctttt gtttttttat tcttttcaaa tatgatttta tccaggcttg tgaactggag 1341661 ctttgggtga accggtttgg agtgtcgtat gacttgcgca tacgtgcatt cggtccagtc 1341721 catttggaat tcgaaaccga taaacgatac ctctcttaat gtgccttgga gaattgttaa 1341781 gtattgaaca gctgcacaaa tcgaaggttc aagcgtaaat tcgcctgagg gtgtttgatg 1341841 tccgtgctgt tccataatct cgcgtatagc gcttttttcc tcatcacgca ttccgtgcga 1341901 gacagaggca atcggtgtca ttattccgtt ttttaacacc gataccgtca gaaacccgtt 1341961 gttagggttg aaccctgtta tgcaaacata agcttgttta aagtttttat atttgagcca 1342021 atcggacgac cgcttctttt caagccattt gctgtttgtt ttcttcgcta caattccttc 1342081 tccgtcatat tttattacca tctcccagag ttgatcaaaa tgatcataac agggaatgga 1342141 ttgaatggtt tcttttgcgt aaggatctgg agatgcagga agctttgctg cggatatgag 1342201 ttcacgcagc gattttttgc ggtccaaata cgaaagaagc gttacatctt ctccgcttcg 1342261 ctctaacaaa tcaaaggcga gaaagcagca cggccgcgcg tttgccgatt cctgaatctt 1342321 gtctggcctt ttcaaacgcc cccgcacttg aaggtgttca aaatctgcac gacagggatt 1342381 caccaaacat acgatttcac cgtcaagtgt cagcggaagc tctttttcta ggtgctgaaa 1342441 ggcagttttg gcgaattgtg tgatttcagg gaaggtgctg ctgagctcca caccatttct 1342501 gctggttaag gtcacacctg aagaatggat gcggagaata cagcggtacc catcatattt 1342561 tacttcgtaa cgccattctg ctccgattgg cggtgacgaa gttaagaccg gctgcatggt 1342621 aaacgccatg cgctatgatg tgccggaggc tttttttcta gttgtttttt gttttttatc 1342681 tccggctcct ttcggttcag cggcttgtgc aggtgcggca gccggtgtct cccggttcgg 1342741 ccttctggtt ctgtcgatgc tggcttgcag agcgcttacc aggtcaatga catcttcacg 1342801 aggtggcgct ttatcaggag tgacagccgt ttctttattt tctagcttgt cgttgactct 1342861 ttgcagcagc gcctgtcggt acgtgtcttc atatttctca ggctcaaact tagcagtcag 1342921 ttcatctatt aatgtgatag cagtttgcag ttccttatcg tttacattcg attgatcagg 1342981 tacacctggg acttgagcgg cgcttctgac ctcatcggga taatggatag actccatgac 1343041 gatacaattt tcataaacgc ggagaatcgc cagctgctgc tttgacctga ttgtcatatt 1343101 ggcgataccg atctttccgg ttgagcgcag cgcctcacgc agcagggtat aggccttcgt 1343161 cccattatcc ccggggccga caaagtagga gcggttaaaa taaatcggat caatttcctg 1343221 aagctgaaca aagtcaacaa tctcaactgc tttctcctca tgctcctgtt ttaagctttt 1343281 taaatcttcg tctgtcagca ctacatattt tccttttaca tattcatatc ccttcacaat 1343341 ttcatcagga ctaagagttt tttcgcaatt tgtgcaaact ttctcgtatt tgattggtgc 1343401 gtgatcctct ttatggaggc tgcgcagttt aatatcttta tcttctgtgg ccgcatatag 1343461 cttgatgggg atgtttacta atccgaagct gatcgatccc ttccacattg tatgcatatc 1343521 gataaacccc tttttttctt tagtgtgaag agaaggagta cgattcatgt gtagtaactt 1343581 atgggtgaaa aaaagccggc gctgttattg cgacggctgt tcaataatga attgttcgaa 1343641 ttgttccgga ggtattggcc tgctgaaaaa gaagccctgc aaatggtcgc agcctttttc 1343701 aaaaagaagc tgcttttgag ctgcattttc cacaccttcg gcaatcacct gcaaagacag 1343761 ctgatgcccc atggcaataa tagctccggt aatttgctct gatttaggat gggtctgaat 1343821 atcgtcaata aatgatttgt caatcttcag cctgtgaatc gggaagtcct tcaaatagct 1343881 aagagagctg tgaccagtac cgaaatcgtc aatactgatt ctgattccta attctgttag 1343941 ggatgacaaa acctttttgg agtgattgag attgtccatt gtcatgcttt ccgtcacctc 1344001 cacttcaaga agctgcggag gaagctggta cttattaagc gtatccttga tgaggggaat 1344061 cagatcttta gattgaaact gtctggcgga aatattaatg gcgacagaaa gatcatagcc 1344121 tttgtcatgc caaatccttg cctgcttgca tgcttcatct ataatccact ttccgatatc 1344181 aataataagt cccgtttctt ctgcaacacc gatgaattct ccgggcggac gcagttgccc 1344241 gtctggtgtc acaaggcgta tcagtgcttc tgctcctgtc attttttgtt ttttcacact 1344301 gaattgcggc tgataatgca agacaaatct atcgttttcg attgcttctc tgagtaccat 1344361 ctcttggtta agcttaacgg tttctttgtt gccgattgaa aaagaatagt atctgtattt 1344421 gcttttgttt cgttctttag ccgcatacat cgccatatca gcctttttca tcaattcaag 1344481 gccatccgtc ccgtcttttg gagatatcgc aatcccgata ctgacagatg tgacaagggt 1344541 gtgatcttga attttgaaag gttttttgaa tttttggata atttttcttg ctaaaacatc 1344601 tgcttcgcct gttcctgtat tggcgtctgt taatataata ataaattcat caccgccaag 1344661 acgggcgata aatccgttat cagggactac agatgacagg cgtttagctg caaactgaag 1344721 caattgatca ccgacattat gccctaatgc atcgttaatc actttaaacc ggtttaagtc 1344781 aagaaagaat acaacagtgt tataatgcaa ggaatgctcg cgattcagca cctttgttag 1344841 atgagagatg gcatgccttc tgttaggtaa gtctgtaagc gaatcataat gagccattct 1344901 atggatttct ttttctgctt tgtactgctt cgtcatgtct ttacaaatga cataaatgct 1344961 gtctagttcc tgattgacct caacaggtat aagcgtaata tttaagtgaa actggccttt 1345021 ttcagtgata agatcgctat cgctgttcat cgcttgttta tcttttttaa cttgctcaaa 1345081 aaggcgctta accttcagtg atgtgtaatt cctccagtca tgcatgctga agccaaattt 1345141 gctgatcatt tcctcaccag cgtgattgga agatattatg tctccttcta atgataaaat 1345201 aaaaattgca tcaatattgt ggacgattaa agactgaaat cgctgttcgt tatcctttat 1345261 gcgttcgctc tgtttaataa actttcgatc tgcatgggaa ctgaataaca ataacgtttg 1345321 gatacaaaaa ataattaaag taacaaaaat tgaccaatga aacgtttgca cctccatatg 1345381 gcttccgggc ggagccatgt ccttatggaa agttgccgca agcatccctg tgtagtgcat 1345441 gcccgaaatc ccaatgccca ttacaattga actgacgcct ttatagaata taagatgctc 1345501 agaatgtttt tttacggcca agtcaaagaa tatttttaac gagacgaaag aggctgcaat 1345561 cgcaatgata attgaaactg taaataaaat aggttcgtaa ataatcatta cccgggaaat 1345621 ggcagacatt ccgatatagt gcatagaagc aatagatgcg ccaagcacaa ctgatccggt 1345681 aagcagtctg taatatgtaa gaatgtgccg gctgacaaaa tataatgaca caaatgatcc 1345741 cgaaacagat gcgccaatgg ctgccattaa aggcatgaat tcatattcca tcggcatttc 1345801 catatggacg gccatcatcc ctacaaaatg cattgaccaa ataccgaatc ccataataag 1345861 tgagccgccg atcagccaaa ttttactttt taagcctgta ttgatggtga ctttccttga 1345921 aagttcaagg gaaatatacg aggcggtaca ggcaattaga atagataaac atatgagagt 1345981 cgtattatat gtaacgtgta tttccaaatg gagattcccc ccgtatcgtg tgttccagtc 1346041 ttgttgactc tctttattat cggctgctta accgcagagt ttcagccttc aaaacgatag 1346101 aaatacgagg gagatctatt tttagttcaa ctgaccgtga aaaatgtgtt aaaatcatct 1346161 tgatgttttc cgaaaagaga aaaatgtatg atacataaac atgaaacaag ggagttggtg 1346221 gctatcgaag agctggttat gtcatggatt gaagcattta aaagcttatc ttattttgga 1346281 atatttctag cgctcagcat tgagtttatt ccggccgaag tcgtcttgcc gcttgcgggc 1346341 tattgggtat ctaaaggcga tatgacactt gctggcgttg ttttggcagg atcgcttgga 1346401 ggagtggccg gtccgcttac gctgtattgg ataggccggt acggaggaag gccgtttctt 1346461 gaacgttttg ggaagtatct ctttattaaa cctgaagcgc ttgataagtc agataatttt 1346521 ttcaaaaaac atgggggctt tgtcgccttc agcggccgtt tcttgcctgg tatcaggaca 1346581 ttgatttcca taccgtgcgg aattgcaaaa atgaatgttt gggtgttttc gctttataca 1346641 ttcattgcta tgcttccgat tacatttgta tatgtttatc tcggtgtgaa gctcggtgaa 1346701 aattggaagg cagtcggctc tattcttgat caatatatgc ttccgatcgg gatagcgatt 1346761 ttggcgctgt tcctgctcta cttactgatg aaaaagagga agaaacgcac gcactccgaa 1346821 caattatctg tatttttgaa aaataaacgt tgacaaatca ctgcgctgcg catattattg 1346881 acgtataaaa tcatatttct tgaaatccca aaggggagta gcgtccggaa tgtattccgg 1346941 aaacaaagtc gtcatttcat ggattgtatc catcggcttt gttggcatgc ctgaattcat 1347001 gtctagcaag acctttgcct tatgtcggca aaggtctttt ttgcatggtc cggccggcat 1347061 aagatcggat gaagagaaag aaaacaactt ttttgggagg gtatcattta tggatgcagc 1347121 attattatta gagtatggtt gggttcttct cgtcttgatc gggctggaag ggattttagc 1347181 cgccgataac gcgctggtta tggcggtaat ggtaaaacat ttgccggagg aaaaaagaaa 1347241 aaaagcgtta ttttatggat tggcaggggc ttttgttctg cgatttggct ctttatttgc 1347301 aatttctttc ttggtcaacg tatggcaggt tcaagcgatt ggcgcgatct atttgctgta 1347361 tatctcagca agccacttat tgaaaagata tgtatttaag aaagaagaca cacataaaga 1347421 gacgaagcaa agcggttttt ggccgactgt tttaaaagtt gaactggcag atatcgcgtt 1347481 tgctgttgat tccatcttag cagcagtagc gctggcggtt acacttcctg ggacatcact 1347541 cccgaagatc ggcggacttg acggaggaca atttctcgtc attttggccg gcggtatcat 1347601 cggactggtg atcatgcggt ttgcggcttc catgtttgtg aagttattaa aggaacgtcc 1347661 aagcctagaa acagcagcct ttgtgattgt cggctgggtc ggagtgaagc ttgctttata 1347721 tacgcttgcc catcgcgaca tagcggttgt ttctgagcac tttatccatt ctggaacatg 1347781 gaagctgata ttctggggtg tcttagcagc aatcgcggtt tgcggctggt ttatgtcagg 1347841 tgggaaaaaa cagccggagg gtgcacaaaa cgaacaaaaa aacagcaccc gtgaacgggc 1347901 gtaatctgaa agactctgct taaaagcaga gtctttttgt gtttgaagcg ttttcataag 1347961 cgaaataaaa taacattttt ataacatctt tgttacaaaa aacacgcata aaaccccctt 1348021 aattctttag aaaggcacga aatcatgtat agaacgtcag aatggtttgt cataattgag 1348081 acattggaaa tcaatatttc tttttctcct ttgcgaatcc ctatcaaatt agctatcatt 1348141 aatgagtagt tatagggagg aactgaggtg aaaccagtgc ttagcctttt gtttaaattg 1348201 ggaaaaaaga agcaaacact tgaaaaagct gttgagagta tacaaaaagg caataaagat 1348261 ctgcaaaatg aattaataca gcaatataag ccatttatcg caaagacggt ttcatccgtt 1348321 tgtaaacgat atatagatga aaaagacgat gagttcagta ttggactgat cgcgtttaat 1348381 gaagctatag aaaaatattc acctgaaaaa ggaaattctc tgctcgcatt tgctgagctt 1348441 attataaaaa gaaaagtcat tgattacatt agaaaagaag ccagaagcgc acaaaatata 1348501 aatatcgatt tacaggaagg agacgatcag gagtcatcac aaagcctgat tgaagccgag 1348561 ctttccattg atgaataccg ccgtcagatt gaacaggagc agaggcggga ggaaatcctc 1348621 tattttcaaa agcagctcaa ggattatggt ttatcgttta aagaactgct tgaaaattct 1348681 ccaaaacaca cggatgcaag gcaaaacgcc ataaaggtgg caatgacgct tgttgaacat 1348741 gaagaattgg ccgctatcct gtatacaaag aagcagcttc cggtcaaaca gcttgaacag 1348801 cttgtctctg taagccgaaa aacgattgag agaaacagaa aatatattat tgcgatgtgt 1348861 attatcatta cgggtgatta tatttattta aaagattatc ttaaaggggt gctgcactca 1348921 tgagaagagg gattatagta gagaaaaata aaaaattcgt cacgttgctg acccctgacg 1348981 gacaattttt aaaagccaaa aatgatcgac acagctatga aatcggagaa gaaatcatgc 1349041 ttccgagtga aacacgcatg ggcagaaggg ccagcttttt tgattttttt aaactgcgcc 1349101 ctttcaaaat ggggattttt acgatgactg ctattatgct ctttattttt atagttctcc 1349161 ccgttttttc taataataag gcctatgcgt atatgacaat cgatatcaat ccaagcgtcg 1349221 aaatggcgtt aaacagcgat tatgaagtga ttgaactgac gcctctaaac gatgagggac 1349281 agaaagtcgt gaatgatata gatgattggg agaagactga ttttaaaaag gtgattgacg 1349341 atattataac cgactgcagt gaacacgggt atgtaaaaaa atcgaaagaa atattgattt 1349401 ccactgttta tgaaaacaca gaagacaata catataaaaa ggctgtgaaa aaacagctga 1349461 atgatgtgac tgaaaaatat aaaacgacat accgcatgga atctctcgag tcagatatgc 1349521 aaacgaggga aaaagcgaag aaagaaggcg tctcaacagg cagctacatc aaatcaaatg 1349581 aaaagaatga caataaagat ataaaagatg actccagcaa accatccggg gaagaggatc 1349641 aaaagagtga tgaaaatgag gatgaaaaca ccgatcaaac tgacacccag gacagcaagc 1349701 aaggagataa tgaacagctg aatgatgcgg attccggaga ccagaaagaa gagaaagcgg 1349761 atgaccagat tgatgatagt gacaaagata aaaaaataaa ggaatcagat gaaaacacaa 1349821 ataccgaaaa agatggggac catgagcaaa ccccaataca agatcctcaa gataaaggaa 1349881 atgaaaataa cggcgctgac aagggccaaa gccaatatca cagggactgg aacaatggtg 1349941 aacaaggcaa gaaccgttct tcgtccagaa gggataacgc ttcagaccga cgtaatccaa 1350001 acggctacag cagtgataat cattcagcta aaaatgaaga ttcgccgagt gcccccggcg 1350061 aataaagacc tgaatttatt tagttgtgcc atttaattgt gattgtgctt gctgtaccag 1350121 ccgctttgtc atttctccgc ctacagagcc gttagcgcgt gcgactgtat cagaaccaag 1350181 gttcacaccg aattcttgag ccacttcgag tttaaattgg tctagtgcct gctccacccc 1350241 tggaacaacg agtttatttc tgctcgccat ctttttcatc tcctttttcg ataaagaaat 1350301 tcttaacgcg tatttagttt gaaatatacg gggtttattt atgctggcaa ttgttgtgga 1350361 gaaaaataaa accccggcct ctgagccggg gtggcgcaga ctatagaatg tctgctgtca 1350421 ttttatgtgc ggttgcctga atatggaatg tcaaaatgga gaggactgta atggcgataa 1350481 tctgtctgat tttaagccat tggctgtcat tcagttcttc aaaacggtga cggagacgct 1350541 ctgtctcctg ttcggcgatc tcctgcagat ttgattcttt catagaagga gtatcttggt 1350601 gatggatggc atcaagcaca tatgcgcagc tttcataata agcaatcggg ctgatgacat 1350661 catcagatct gtctgagatt gtgttaaagg ccacttttaa aatagcccgt atgtgttcaa 1350721 agtcataaat ggattttaaa tcacgtacaa ttaaaagaat aactgcctgt tcaattgagt 1350781 attttttgcc cagctcaggg tgtccgatca gatctttgat atcacgcttt acccagtttt 1350841 gaatcgcggt tgactttaac gaagtcagct cgcataagtt gccaagctct acgatttcat 1350901 ttgtagacag accgtattct tttttctgtt tttttcgttc gtatcttgta agaaattcag 1350961 gaatttctag atgattggct gctttttctg ctgacatgtt cgctgattgg acgagaatgt 1351021 cgagcgggct atgttctcct tgtcctttta gggaatagag cagccgcacc atatcggttc 1351081 gagagagttt aaaaatgttc attgttcacc tctttaaaca atttgacgcg gatataggtc 1351141 tatgtataag ttcaaaattc aagcgtcagc aaattacatt aacatcatac gtcgaattcc 1351201 ttgcattttc aaatggatgt tttataattt aaatatacgg gttcttttga acttaaaata 1351261 acggaggttg ttatggcgaa aagaattttt ctgtttattc taacgaatat tttggtgctt 1351321 acaacaatcg ggatcgtttt gtctgtttta agctctgtta caggagtcgg gacgtacttt 1351381 acagctgatg gcggtatcga tccaatggcg cttcttgtgt tcagtttagt cgttggattt 1351441 gtcggttcct ttacgtctct tgcgatatcc agatggatgg caaagacgat gatgggcgtc 1351501 agagtgctga atccgaaaaa acactcgctc agctatgagg aacagcaatt ggttgatcgt 1351561 gttcacagat taagccgctc tgccggttta acgaaaatgc cggaagtcgg gatttaccgt 1351621 tcacctgaag taaacgcgtt tgcgactgga ccgtcaaaac gccgttcact tgtcgcagta 1351681 tcgtcagggc tgctggagca gatggatgac gcagcagttg aaggtgtgct tgcccacgag 1351741 gtcgcgcata tcacaaatgg tgatatggta acaatgacgc ttttacaagg tatcgttaat 1351801 acctttgtcg tctttttatc gcgtatcgcc gcttggatag caagccgttt tgtcaaagaa 1351861 gatctagcgc cgatcgttca ttttattgca atgattattt ttcagattgt cttttcgata 1351921 cttggcagcc tggttgtgtt tgcgtattca cgccatcgtg aattccatgc tgacagggga 1351981 ggagcggatc ttgccggcaa ggacaagatg attcatgcgc tgcggacgct taaaagctat 1352041 tcttcccgga ttttggaaga cgatcagaca gctgtccaaa cgttaaagat taatggcaag 1352101 aagcgctctt cacttttctc tactcatcct gatttagatg agcgaatcag acggctggaa 1352161 gctaaataat acaaacacat tgttcctctg agagaattct cagaggtttt ttattttatc 1352221 cattgactaa aatcataaaa aaataagcaa gttaagaaaa tgtttcgtaa aagcctttaa 1352281 aaatggacct aatatcttta gaataattac cgtacttaaa aagagaggca gaaggatttt 1352341 acatgagatt aaagtttgga aaattgatac aggccttgtc accggcccag ctgatcgcat 1352401 tatattattt tcttgcagtt actgtggccg ttatattgct gagtttgccg gcggcccata 1352461 aaccgggggc ggattggacg tttattgatg cgctttttac agctgtcagt tcagtcagtg 1352521 taacggggct gacagttgtt gatacagctg atacattcag cacaataggg atttttatat 1352581 tagcatttgt tctgcaattt ggcggaatcg gaattatgac gctcggaacg ttcatttggc 1352641 tgatcatggg aaaacgaatc gggctgaaag aacggaagct gattatggtt gatcaaaacc 1352701 aatcccagtt ttcaggaatt gtcaatctga tgaagcaggt actgtttctg atcttgtgga 1352761 ttgaattttt tggcgggctg atactcggca catatttctt aacctactat gactcctatc 1352821 aggaagccta tttacacgga ttttttgcca gtatcagtgc aacgacaaac ggcggatttg 1352881 atattaccgg taattcgatg attccatttc gccacgatta ctttgtgcag tttattacaa 1352941 tgcttttaat tatatttgga gcgattggat ttcccgtgct tgttgaagta aaggatttcc 1353001 tgttttcaaa gcatcggcgt tatccattta cgctttttac aaagatcacg acgattacgt 1353061 tcggctcact tgtcttgttt ggagccattg gcatctttgc cctggaagca aaccatgcgt 1353121 tcgcaggaaa atcatggcat gatattttgt ttttgtccct gtttcaatca acggcaaccc 1353181 gaagcggggg gctggcaaca atcgatatca gccaattatc agattccaca ctctttttta 1353241 tttgtgcgct gatgtttatt ggagcgtcgc caagctcagt cgggggaggc ataaggacaa 1353301 cgacttttgc tttgaacctt cttgcgctgt ttcattttgc ccgcggcaat aaggccgtaa 1353361 aggtattcaa acgggagctt caccctgctg acttgatgaa gtcgcttgtt gtcacgatga 1353421 tggcgatcct gctcgttttt ggcgcgacac tcattctgac cattacagaa aaacattccc 1353481 tgctggagct tttgtttgaa gtgtgctcgg cattcggtac aaccggccta tcgcttggaa 1353541 ttacggcaga tttgagcagt gttggaaaat gcgtcattat gattgtcatg tttatcgggc 1353601 gaatcggcat cttgaccttc ctgtatctga tcggaagaaa ggaaattgaa gcgaattatc 1353661 actatccgaa ggaaagagtg attatcggat aggcaaaaca ccgcatattt tgcggtgttt 1353721 tttgattacc aaaaaaaaga tgtgtgcctc ctgttcagtt ggagaaccta actccgacag 1353781 gtgcaattta cgctcctgca tcttaaaatg tctgaaaatt ggcgaggagg attcgtatga 1353841 agcgtaaagc tgaagtgaat gaagccatta aaaataacaa tacacctacc gagagcatgg 1353901 accccaattc atataagaca caatatcatg acgaccccaa ttttagaggg gcaaaccgca 1353961 attccaaaca gggccagcag ggaggcatgt aattgtgaag aaaaaccgtc atagcagaga 1354021 catgcaaaat cataaaaagc ctatgaataa aaaggtgctg gaggaagaat tctcaagtga 1354081 actcggggat tacaatgccg gaaagatcat cgaaacgctg gaagtcacca agcctgaaaa 1354141 gaaaaaagaa aaaaacaaaa aacaacaata aaaaagacct cttaggcggc gtcccgctta 1354201 agaggtgctt tttctatttt aaataagcat ttttgcccgt tcctctgaca aattgcaata 1354261 agcttgtcat cctcagctca atgaatggct gagcgactgt cttaacaaag ttgctggaga 1354321 ggactgatgt cagggctgct gttaaaagca agaggatcac taagctttga tagtcagtaa 1354381 gccaatcctc aagcccgacc tgccgtaatg tcttaataat aaacccgtga agcagataca 1354441 cgtaaaatgt ccgggttccc catttggtaa agaaataccg tttttgcgga acgagcgcta 1354501 aaaagctgaa ggttgcccca aaggcgagta cataccagcc gattcgggat agtccgctta 1354561 ccagggtaac gtctccaaat gaagaatacg gttttgaacc aaacagaaaa gaatagtcaa 1354621 aatcgatgcc ccagcagatg acgaatactg cggcaagcac tccgagcgca atttgtttgc 1354681 cgcgttttga tctcaataaa tcaaaatgat gtttatttaa ataaaaaccg acaaggaaca 1354741 tcggtaagaa tacgaatgtc cgtgacaagc tcagcgtgct gctgacaaag tccagataac 1354801 cgatcagcac ggcgattccg cagctgacaa acagcgccca ctgctttgaa agctttgaaa 1354861 aaggatatag gagcaggttc caaaagaata agcttacaag aaaccataac gaccattgcg 1354921 gatcaatcgg gttcacattt gccatgcttt catcttgcat aatgtaataa aagacggaat 1354981 aaataatttg gaaaatcaaa tacggaataa tcagcttgac cgccagcttt tttacatatc 1355041 ccgcccgttt aaagcctttc gcgaaataac cggatacaag aataaatgca ggcatatgga 1355101 atgtgtaaat gaacttgtag aggtagagca taaaatgatt atcattaata aaggaacgaa 1355161 ggatatgacc gaatacaaca aggaatatca ataaaaattt tgcgttatcg aaataactgt 1355221 cccgcgattt actcatagca tcaccttctc tttcatcagt cactaagaga ttattccctg 1355281 ctggtacata ttttaaaata aaagatgaaa aaggaatcta aaaaaatgct gattgttagg 1355341 tcgatgtaaa gtgacggtaa ggatcgtaga aaatgtcttc gtaatgtaat gacgctgaaa 1355401 ttttctgaaa tttatagggc aaatgaagga agttcccgca ttttgtagaa atattgaggg 1355461 ataggttttg aagaaggagt gtacatgcat ggaaactctt ggtgtccaga caaactcgga 1355521 gctgcgagag gaactgaatc gcctcaaaga agaaaacgcg cgactgaaaa aggaattgaa 1355581 tcagcatcaa gtgattgtca acaatacgct cgatgctatt tttatttgtg ataacgaaat 1355641 gcggattgtt caggcaaatg aagcaacaga aaggatgctt caagttgact cggaagattt 1355701 gaaaaagcgt tctgttttgg attttttgtt ttcaatccca aaggatgaac tgaatctttc 1355761 cgtaaagaag ttttttaaaa aaggctttct gtggaaggag gttccgatca ggcttgattg 1355821 cggggcaaca aaatacatag agtttctggc caaaagaggt attggtgagg atttcttttt 1355881 tgttgtcatg agggacatat cttctaagaa gattctggag cgggaattct ctatgaatga 1355941 acagcttttt aaggacttgt ttgacagagc agttgacgga atcgtcctgt ttgataaaga 1356001 tggcggtttt attgatgcaa atttgtcctt ttgtaaaagc tttgaaatca atcataatga 1356061 gctgtctcat ttatctttgt atgagttcat agacagcggc tcacgaaaag atttcgacaa 1356121 tatctggaag gcgctcaacc gcaagggaaa agcgaagggg gagctgcctg tcaagcttcg 1356181 ttcaggagtt caaaaactat ttgaattcac gattacatca aacatcatca gcggttttta 1356241 tatgtccatt atgagggata tcacagagaa gcggtctatg gagctgcagc tctttaaaag 1356301 tgaggagcgc ttcagagaaa tctttgaaaa tgcaatggac gccatcatca tctggtcgaa 1356361 tgacggaaga atcgtaaaag cgaatcaatc agcctgtaaa atttttgagc tgccgatgaa 1356421 tttgctgttg aaaagaaagc tgtgtgattt tctcgttgac tcgcagcaga aatacagcat 1356481 aacgaagagg aaatacgcaa aatacggaga gatcagagaa gagctgctgt ttcaaatggg 1356541 gaacggccaa ttcaaagagc ttgaatttac ttcaaaacgg acaatccttg aaaatcagca 1356601 tttgacgatc ttaagaaatg taagcgacag aaagcggatg gaaaaggagc ttcgggaaag 1356661 cgagctgaaa ttcagaaaag tgttcaacgg atcaatggac ggcaatgtat tgttcgacaa 1356721 tcaatacagg atcatcgacg ccaacccgtt agcaagccat attttgggcc tgtcacatga 1356781 agagatcaaa cagcacagcc tgttagatat tatttctgct tatgaaatag aaaatttggc 1356841 atcaccggca aggcagatta attttgatga aatggacaac gaaattccat ttttgctgag 1356901 cagcggtgat aacagaaaac tcgaattctc atttaaacgg aatattattc aaaatatgaa 1356961 cttggctatc tttaaagacg taacagagcg aaaagaattg gaggagcgcc tgcgcaaatc 1357021 agataccctt catgttgtcg gcgaactcgc agccggtatt gctcatgaaa tcagaaatcc 1357081 gatgactgct cttaaaggct tcattcagct tctgaaaggg agtgtcgagg gagactacgc 1357141 cctttacttc aacgtgatca cctcagaact aaagcgcatc gaatccatca tcaccgaatt 1357201 cttgatttta gccaagcccc aggccattat gtatgaggaa aaacatgtta cccaaattat 1357261 gagggacacg atagaccttc taaatgcgca agccaatctc agcaatgtac aaatgcaact 1357321 tgatttaatt gacgacattc ccccgattta ctgtgaaccg aatcagctga aacaggtttt 1357381 tatcaatata ttaaaaaacg ccatcgaagt gatgcctgac ggcggaaata tttttgtaac 1357441 gataaaggca ttggatcaag atcatgttct aatctcctta aaagacgagg gaatcggaat 1357501 gacagaagat aaattaaagc gacttggtga accgttttat acgacaaagg aacggggaac 1357561 tggacttggg cttatggtaa gctataaaat tattgaagaa catcaaggcg agattatggt 1357621 agaaagtgaa gaagggaagg gcaccgtttt ccatattacg cttcctgtca gacagaatgc 1357681 tgaagaaaga aggaatgatg aatgaactac tatacgacag ccgaaacgcc gctcggtgaa 1357741 cttatcattg ccgaagagga ggaccggatc actcgtctat ttctcagtca ggaagattgg 1357801 gtggattgga aagaaacggt tcagaatact gagcataagg aaacacctaa tcttgcagaa 1357861 gcgaaacaac agcttcaaga atatttcgca ggcgaaagga agacattctc cctgccgctc 1357921 agccaaaagg gcactccttt tcagcaaaaa gtgtggcaag cgctggagag gattccatat 1357981 ggcgaatccc gaagctatgc ggatattgcc gctgctgtcg gcagtccgaa agcggtgcgc 1358041 gctgtcgggc aggctaataa acgtaacgac ctgccgattt ttgtcccgtg ccacagagtg 1358101 atcggcaaaa acagtgcgtt aacaggatac gccggaagca aaacggagat caaagcattt 1358161 ttgctaaaca tcgagcgaat ctcctataaa gaaaaataaa acatatggca cgttcccttt 1358221 tttcacggcc gacatatcat tttattaagt taaaaaagtt ggtctgatga aaaaggagga 1358281 caaagcaatt gaagccgagc cgctctgaga aacttgccgt ttttgccgaa ctgtttgtga 1358341 aactgcatat cttatcaagc gctcaaaaag atgaaatcat caatgttaac aaaaagaaac 1358401 aaaaaaaccg ctgactcggc tccaaatgag caaagtccag cggtttttta atgcaccttt 1358461 tctcctttaa acagctgttc aatctcttct tcatagtttc cggtcataat ccctttttct 1358521 gtgatgattc ctgaaatgag atcatgaggt gtaatgtcga aagcgggatt aaagacaggc 1358581 acattggatg gagcggtccg aactccggaa atctgcctga cttcctcggg atctcgttcc 1358641 tctatcggga tatcagcgcc gcatttgacc tttgtatcaa atgtagataa aggtgcggcg 1358701 acaaaaaacg gaatatcaaa ggcgtttgct aaaatagcaa gaccgtatgt gccgatttta 1358761 tttgccgtat caccgttctt tgcaattcgg tcggctccga cgataacagc ggaaatttgt 1358821 ttttccttca tcgtatgggc ggccatgctg tctgtgatca gagtgacatc aatgcccccc 1358881 tgcatcagct cccaagcagt aaggcgtgaa ccttgcagga caggccttgt ttcacaggca 1358941 taaatgtgta atcccaaatc tttttgtttg gccaagtaaa acggagctag cgccgttcca 1359001 tagcggcttg tcgcgattga gccggcattg cagatcgtca tgatcctgtc gccttttttg 1359061 aaaagctgca gggcgttttg gccgatcaac cggcacgttt cctcatcctc gacctgaatc 1359121 tgaatggctt catggacaag gtttgttttt gcttcattta cggaaatcgc gttttcgacc 1359181 gaatgactca gtctctcaag cgcccatgac aaattaatgg cggtaggccg tgagctgttt 1359241 aaatattgtt tgatgtcttc cagtctgcgg cggaattccg tgacattgtc tgtttcaatg 1359301 tctttggcag caagcgccag tccgaaggca gctgtaatgc cgatcgccgg agcgcccctt 1359361 actttgagcg tgacaatcgc atcaaataca tcctctttcg tcgtcagctc caaatattcc 1359421 gtctcatcag gaagcttttg ctgatttaaa atggtaatag ctgtttcttt ccattcaaca 1359481 gaacgtggaa cagcaaatga atgggtcatg aatagatcat tcctttacaa gtaacttaaa 1359541 taattcaata acatctgtta tcgttttgaa ttccgaacgt ttttcgataa aggctgtgcc 1359601 ggtttcgagc gccaagcgtt ttctgccgat tcgtttatca aacggcacga tcgtatccag 1359661 gtcagctaca tgggcaaggc cgatcgtgcg tcgtatcagc tcacagcccg caaatccgat 1359721 tgcttcttca aaaatatggc tgagcgtatc agtgaggtaa ccgtcgatgt tggcgtaaac 1359781 atccagactg tccttctgcc aggcttcact aaacgtctct tcaaacgttt cccagacctg 1359841 gttgacatgt tcatataacg gctctctgtc agccccgtca cggctgagtg cgttcaaaaa 1359901 taagttggcg ataaattgcc ctacatcaaa gccgatcggt ccgtaaaaag caaactcagg 1359961 atcaatcacc tttgtttcgt gctcacttgc gaaaatgctt cctgtatgca aatcaccatg 1360021 aatcaacgtt tctgcagacg ttaaaaatga ctttttcagc ttagcggctt cgattttaac 1360081 gctgtcatta ttccaaagct tttcgacaaa aggacgaagc tcttcttcaa aatcatttgt 1360141 gtcatggtcg aagaaaggat ctgtaaaaac aagtctttcc gtaatgtcgc atagctctgg 1360201 atttgtaaac tgtttaacaa gctgtttttt caccttaggt tcaagcgcgt aatctgatga 1360261 gtagaaaagt gtttttccta aaaattcacc gatgtgctgc gacagatgag gatagttttc 1360321 accctcaatg agtccttttc ttgcgatctt gaggtgagag agatcctcca tgacggtaac 1360381 cgccatttcc gtatcagaat aaaacactct tggaaccagg tgaggcacat gctcgccctg 1360441 acggatgaga gcgctgcttt cgattcttgc acggtcgatt gtcagcggcc agctttctcc 1360501 caccactttt gcatacggaa ccgcctgttt aatgatcaat gctctgtcat gttcttgatc 1360561 ataaatatga aaaacgtaat ttaagttgcc gtctccgatc tcctggcatg tcagcgtgct 1360621 tttgcttgga aataggccaa gcttcaccgc caacgccaca gcggagcttt catttaacgt 1360681 ttcgtataaa ggtgtttttg tgactcccat catcataacc tccaattatg taattaatta 1360741 atatgtggcc gtaaaaaagc ctccttctca gagagaagga ggcttaacat ctatgtccgc 1360801 ctctcttatc tctcagatca gatctgaatg gaattagcac cgtgccttaa gagaccagcg 1360861 tctcggcgcg aaaaaaatgc gccccatttc acaatggaat tacggtcggt tgcttttggg 1360921 gtcaaaaggc caaatccctc gcccaactct cgataagaga atatattcac ttgtttgaca 1360981 attctaattt atcagttgat gaacatggta acaggtaatt tagttagttg tcaatatatt 1361041 ttttaatata aatcttttct gatatcatcg aaaacaggaa tgctctcccg aacttctgcg 1361101 ctttcttgaa ggtcgatttc cgctcggact atgccttctt cccggccgcc ttcagcaagt 1361161 acacgtcccc atggatcaat aatcaggcta tgtcctgcaa attcattatc cggatttgaa 1361221 ccggtacaat tgcaggctgc gacaaagcat tggttttcaa tggcccgcgc aataagcagg 1361281 cttttccaat gatcaaggcg gggaagaggc cattccgcag aaataaacag cacgttggcg 1361341 ccttttgtcg tatgttttct gatccattcc ggaaaacgga tatcgtaaca gatcaatcca 1361401 gagcttttga cgccgtcaag ctcaaagtat ccgtcttcgg aaccggctga taaatacaga 1361461 tgctcatcca tcagctgaaa aagatgggct tttctgtact ctttaatgat ttgcccttcc 1361521 ttatccgcga tgtacattgt attataaaca tcagaattct tcctgacagc gaccgatccg 1361581 gcgacaatat gaacaccatg tttttttgcc gttttcttca gccagctctg agcggagcgg 1361641 ccgtcttcgt cagcgagttc atcaagattg gccagatcat atccggtcgt ccataattca 1361701 ggcagaacaa gaacatcagc atgtttgctt tctttttcga tgaaaaattc agcctttttt 1361761 atattttccg aaggttttcc gtatgaaata tcaaattgaa gacaagatat cgtccatttc 1361821 atctttttaa caccccaaat ttttctttac ttttttcatt taaccatata tgatgatgga 1361881 ctatcatttc aagatttttt tagaaggtga gaatagatga aatttgaaca gtctcatgta 1361941 ttgaaggaat tgcctaaaca attcttcgct tctctggtgc agaaagtgaa ccgaaagctt 1362001 gcagaaggac atgacgttat caatctggga cagggaaatc cagatcagcc gactcctgag 1362061 catattgttg aggagatgaa acgagctgtc gctgatcctg agaatcataa atattcgtct 1362121 tttcgcggct cataccgtct gaagtcagcg gctgctgcat tttacaaaag agaatacggc 1362181 attgatctgg atccggaaac cgaagtcgct gtattattcg gcggaaaagc cggtctagtc 1362241 gagctcccgc aatgcttgtt gaatcccggt gatacgattt tagttcccga tccgggttat 1362301 cctgattact ggtcgggtgt cacacttgca aaagcaaaga tggaaatgat gccgctcgta 1362361 aaggacagag cgtttctccc tgattacagc agcataaccg ctgaaataag ggaacaggcg 1362421 aaattgatgt atttgaatta tccgaataat ccgactggag ctgttgctac ttccgagttc 1362481 tttgaagata ccgtgcgttt tgcggctgaa aacggaatct gcgtcgttca cgattttgct 1362541 tacggcgctg taggatttga cggctgcaag cctttaagct ttttgcagac tgaaggtgcg 1362601 aaggatatcg gaattgaaat ttacacgctg tcaaaaacgt ataatatggc aggatggcgg 1362661 gttggctttg ccgtcggaaa cgcttcggtc attgaagcga tcaatcttta tcaagaccat 1362721 atgtttgtca gtcttttcag agcgactcag gaggctgcag cagaggcact gttagccgat 1362781 cagacgtgtg tggcagagca aaatgccagg tatgagagca ggagaaacgc ttggatcacg 1362841 gcatgccggg aaatcggctg ggatgtaaca gctcccgcag gttctttttt tgcatggctg 1362901 cctgtgcctg aaggctatac ttctgagcag ttctcagatc ttttgctgga aaaagcgaat 1362961 gtggcagttg cggctggaaa cggcttcggt gaatatggcg agggctacgt cagagtcgga 1363021 cttttaacaa gtgaagaaag acttaaggaa gccgcttatc gaattggcaa actgaacctg 1363081 tttacccaaa aaagcattga caagacctta taacgatggg ataattcaaa ataatttata 1363141 aaatctatat tttcttatca agagcaggca gagggacgag cccgatgaag cccggcaacc 1363201 gacttataaa gcacggtgct aattcttgca gctagcggct gagagataag attcggacga 1363261 gaaacgaaac ctctttagac gcgattgcag tttgaagagg ttttttgata tggatgaaaa 1363321 tgaaaggagc tctggcatga gtgagttatt agcgacatat ctcctgaccg aaccgggagc 1363381 cgatacagag aagaaagcag aacaaatcgc aacaggattg acagtaggct cctggactga 1363441 tctgcccctt gtaaaacagg agcaaatgca aaagcacaag gggcgggtga taaaagttga 1363501 ggagagagag ggaactgctg catcagaaaa acaagcggtc atcacaattg cctatcctga 1363561 aatcaatttc tctcaggata ttccggcttt gctgacaaca gtgtttggca agctgtccct 1363621 ggacggaaaa atcaaattaa tcgatcttca cttctctgaa gcatttaagc gtgcactgcc 1363681 gggaccgaag tttggcgtat acggcatccg gaagctgctg ggagagtttg agagaccgct 1363741 gttaatgagc atatttaaag gcgtaatcgg aagggacctg agtgatatta aagaacagct 1363801 ccggcagcag gcgcttggcg gagttgactt gattaaagac gatgaaattt tctttgagac 1363861 tggtctagcg ccttttgaaa caagaattgc agaaggaaag caaatattga aagaaacgta 1363921 tgaacaaacc ggacataaaa cgctgtatgc ggtgaatttg accggacgta cggctgatct 1363981 gaaagacaaa gcgagacgcg ccgccgaatt gggagcggat gcgcttttgt ttaatgtctt 1364041 cgcttacggc ttggacgtta tgcaaggcct tgcagaagat cctgaaatcc cagttccgat 1364101 tatggcgcat ccagcagtga gcggagcgtt tacgtcttct ccgttttacg gtttttctca 1364161 cgctctttta ctcggaaaat taaaccgata ttgcggtgct gacttcagcc tctttccgtc 1364221 tccatatggt tcggttgcgc ttccaagagc agatgcactg gcgattcatg aagaatgtgt 1364281 gagagaggat gcttttaacc aaacatttgc tgttccgtca gcaggcattc atcccggcat 1364341 ggttccgcta ttaatgcgtg atttcggcat agaccacatt attaacgccg gaggaggcgt 1364401 acatggacat ccgaacggtg cccaaggcgg ggggcgagcg ttcagagcta ttattgatgc 1364461 ggtcctagag gcccagccga ttgatgaaaa agccgaacaa tgcaaggatc ttaagcttgc 1364521 gctagataaa tggggaaagg ctgaagccgt atgacgactc gaaaaccttt tattatttgt 1364581 gattttgacg gaacaatcac gatgaacgac aacattataa atatcatgaa aacatttgct 1364641 cccccagagt ggatggcatt aaaagacggc gtactttcca aaacgctgtc aatcaaggaa 1364701 ggtgtcgggc ggatgttcgg ccttctgccc agcagtttaa aagaagagat tacaagtttt 1364761 gtattggaag atgcaaaaat cagggaaggc tttcgggaat ttgtagcatt tatcaatgag 1364821 cacgagattc cgttttatgt cataagcggt ggaatggact tttttgtata tcctttgctt 1364881 gaaggcattg tggagaaaga ccgcatttat tgcaaccatg cttcatttga caatgactat 1364941 atccatattg actggcctca ttcctgcaag ggcacatgca gcaatcaatg cgggtgctgt 1365001 aagccgtcgg tcatccatga actttctgaa ccgaaccaat atatcatcat gatcggtgat 1365061 tcggttacag atgtggaggc agcaaagctg tctgacctat gctttgcaag ggattattta 1365121 ttaaacgaat gccgggagca aaacctcaat catcttccgt atcaagattt ttatgagatc 1365181 agaaaggaaa ttgagaatgt aaaggaggta caggaatggc tgcaaaacaa gaacgctggc 1365241 gagagctcgc tgaagtaaaa cgggaattgg cagagagaga ttggtttccg gcgactagcg 1365301 gcaatctgtc aattaaggtt acagatgagc ctttaacatt tctcgtcact gcaagcggaa 1365361 aagataaacg caaagagacg gttgaagatt ttctgctggt cgatcaaaac ggagagcctg 1365421 ctgaaagcgg gcattctctg aaaccgtcag cagaaacgct tttgcataca catttgtaca 1365481 ataaaaccaa tgccggatgc tgcctgcatg tccatacggt aaacaataat gtgatttcag 1365541 agttatacgg agaccaaaag aaaatcacat tcaaaggcca ggaaattata aaagcactcg 1365601 gcttgtggga agagaacgca gaagtgaccg ttccgattat agaaaatccg gcacatatcc 1365661 cgacgctagc ggcactgttt gcggaagaga tttcagaaga ttcaggagct gttctgatcc 1365721 gaaatcatgg tattacggct tgggggaaaa cagcatttga ggcaaaaaga gtgcttgaag 1365781 cgtatgaatt tttgttcagc taccatttga aattgaaaac actcgagcat cagctggtta 1365841 aataaaagga ggaattgaaa tggctacaat tcgaattcat gatgaggcaa atacaacgat 1365901 tgaaaatcaa gaggaagtgg caagctttct ggacagtcaa gaggttattt atgagcaatg 1365961 ggatatcacg aggcttccgg aacatctctc agagaaatat gacctgacag aagaagaaaa 1366021 acagcaaatt cttgatacct tcgaaactga aattaaagat atctcaaccc gccgcggcta 1366081 taaagcacag gatgttattt cattgtcaga cagcaatccg aaacttgatg aactgcttga 1366141 aaactttaaa agagagcatc accatacaga cgatgaggtt cgttttattg taagcggaca 1366201 cggtattttt gtcattcaag gccaggacgg cacgtttttt gatgtccgtt taaaccctgg 1366261 agatttaatc tccgtgcctg agaatatccg ccattacttc acgcttcagg aggaccgcaa 1366321 agttgtcgcg gtgagaattt ttgtcacaac tgaaggctgg gttcctattt atgaaaaaga 1366381 cagcgtgaat caataagcgt gagatagccc cgttcatcga acggggcttt ttatatttat 1366441 tgcaaacgcc acttttcata ttgtgacagt tcttttttaa tcagtgtcca aatcaaacct 1366501 aaaacagctg catcgtcaat gaatccaaga ccgaggatta cgtctggaat gatatcgagc 1366561 ggcatgacga tatacaggat tgcggcagtt aacagcaaaa gtgttttaac ctgtgaacga 1366621 gggtagtcgc catttcgcca atcgcgaagc atctgaaaaa aagtagtgat gtgctggata 1366681 catttttttc ggtttttcct ctttaaaatc gcttttccgc ctgccgctcc gagcattatt 1366741 gctttctttt tcttcattgg gcatacctcc tgcctggcgg cgtgtttaag atattcttca 1366801 cctgggtatt gttcttctaa tcctatcaat atatctatta tacctgaaaa attaacttat 1366861 ttaatgaaaa tatgtttaca aataaagtat aatctgtaat aatgcacaat aacccaatca 1366921 aacttgtttc ctatttctta gcggcgaggg gtgaagtgaa tgggcggttc ttctgaacaa 1366981 gaaagattgt tggtgtctat tgatgaaaaa agaaagttaa tgatagatgc cgctagaaag 1367041 cagggattta cagggcatga cacgatcagg cacagtcagg agctggattg tttaataaat 1367101 gaatatcatc agcttatgca agaaaacgaa cattcccaag ggattcaagg ccttgtaaag 1367161 aaattaggct tgtggccccg cagagatgtt atgccagcat atgatgcaaa taaatagcgg 1367221 cctatcagat gcatatataa agagagagct tttcggaagc gctctttttt tctggaaaaa 1367281 attcatatga aagagggaac taatgaagga actggcgatt ctcattaccg aaatggtcaa 1367341 tcaatttcat gatgctttta tttccttatg cggaatattt ggcattcatt taactgacaa 1367401 agaaatgcat ttttgggtga tcggcatttt tggcatattc tttttcggcg tcactcacgc 1367461 tgtgtttaca tggctttcta aatggagtat gacagccttg tcctttatct ataccgttac 1367521 agtcatcatt gtcatcgtat ttgcgattga gattcagcaa aaggtgacgg ggagagggaa 1367581 tatggagttt ttagatgcca cggaaggtat aaagggtttt ttagtatttt ttatgttttt 1367641 tttgcttttg aaaatgctgt tgcgtttcat caaaatcctt ttttctggaa gaccagcaag 1367701 caaatcgaat ggcaatgccc gatcacgaag ataaaaaacc ctcctgacat ggtcaggggg 1367761 gctatgatgc ggatacgggg agggtgatcg tcacctctgt gcctcttcgc acttcacttt 1367821 caatatgaat agagcctccg tacatcagca cgatccgttt acaaacaaca aggccgagac 1367881 cggttccttt ttctttagaa gtaacaaagg gaaggaagat gtgatccagc atttcctgag 1367941 aaatcccttc accgttatcc acaactttga ttatggcttt tttatctaaa gctcctaggg 1368001 agatcgtcag tttgcctcct tcaggcattg actcgaggcc attttttgct acatttaaaa 1368061 tcacttgttt aatatgatct tttgtacatt ttacgagtaa gggctgctcg gttagatact 1368121 gtaattcgac ttcaacattg tatagattgc cctcagaata aatgatcggc ataatttctc 1368181 cgataatgtc ctgaagtgag ttcagctccc atttttcagc tgtcggcttg ccgagaacga 1368241 gaaactcact cactatttga ttgatgcgct ttatctcctg ttcgataatg gagaagtaaa 1368301 gctgatcttc ctcaccttta tatttctttt gcaacagctg aataaagccg cttatcccgg 1368361 tgagggggtt acggatttca tgggctgtgc tggcagcaag cgtcccgatc agctctaatt 1368421 tttgcgcctc gttttctgag cgctccagct gggtctgccg cttcagcaaa taatacagca 1368481 cgagaataaa aaggatattc agcagaacaa taatacatga aagcggaagc acaaggcttt 1368541 tcgacagttc ttctattgtg accgggttcg gatagacttt catattccag ctgatatcat 1368601 ccagatatcc gctgacaggt ttctgatcct ctgcatgaga ggcttgtccg ctcgcaaaaa 1368661 tcattttccc gtcttggttc acaacttcaa tataaacatc agggcttagt aagttaatga 1368721 gatttttcaa ataatcaatt tgaatagctg cgacaagata atctgtcaca ttacgttttg 1368781 agtccaaaac aggcacacaa attgtgaaaa ttggctgacc agtaattctg ctcgaataac 1368841 tatctgaaat gactgtcttt ttagtttcct ttgcttttat aaaaaaagat ctgtcggcca 1368901 ggtttacttt cgtttttaat tcggttgtgc ttgcggtgac gtctcctttg gcattgagaa 1368961 aatagagacc ggaaaatctc ggctctgaat caaaggtctt ttccaaaatt gattgcattt 1369021 tctttatatc aaccggtctg tcgatggcga tggacaagga ggtcattctc gccattgttt 1369081 ctccgattaa ataattgatt ttgttgcggt gaaggtttag caggacactt gcttcttgtt 1369141 tatgttctgc agctattgta tctttttctt tttcatatac gaaaaagctg atgacgattg 1369201 ccggaatcac gaccagtatg atataaagtt tgactctccc gcaggcgcct tttagtattt 1369261 tcaatttgca tcgctccaac atacacctga ttagaggtat tatatcattg tttcttcttc 1369321 tttaataaga aaaaataacc aaaaaaatta gaaaaagatg ttggcaagct tacattttaa 1369381 aaaagaagag aaatattgga aagattttta ttgacatttt ggtctttgtt tattaatgtt 1369441 tctctgtaac ggtttctaaa aggatgattg agacatgaca gaaaaatcac tgaagttatt 1369501 tatcgtgctg tcgcgcgcgt atcggtctat taacgatcat atgaataagc atattcataa 1369561 gcatgggctg aatccgactg aatttgctgt gctagagctt ttgtaccata aaggcgatca 1369621 gccgctgcag cagataggag ataaaattct cttggctagc gggagcatca catacgttgt 1369681 agataagctg gagcaaaaag aacttctcat tcggaaagcg tctcctacag acagacgagt 1369741 gacatttgcg caaattactg aaaaaggcat cggtcttttg aacgatattt tccctgatca 1369801 cgctgctgaa attgatgaaa tgatcagcgt attaagcgaa gaagaggtag agatgtgcac 1369861 cgaaatgtta aaaagagtag gattaaacgc aaaacagttt cataataagt aaaaaaagga 1369921 agcctgatat gtcacaaggc ttcctttttt gctatttttc atttgtttcc gctgcgcctc 1369981 tcggcaaaat gagaacttca acccgccggt ttttgcttcg gccttccgca gttttattgg 1370041 aagccaccgg tttatactcg ccataaccct tggcgctgaa cacttttgca tcgagcttgg 1370101 ggttttcaat caggagcccc ataaagttta ccgctctcat gacgcttaaa tgccagtttg 1370161 attggaattc agaattttta attggcatat tatcagtatg tccgctgata atgatatttc 1370221 ttggcgggtt aatcacaaga agatttgaaa tctcttttgc aagcggcaca tcttccttac 1370281 ggatggtcgc ttttccagaa tcgaagaaga tgctgtcttt aatcgtaatc agaaggcctt 1370341 cactagtcat cttcgtctcc agctgatgtt ccagcttttt atctttgatg aacttttcca 1370401 cctggctctt cacattttca agttcttctt gatcagctgc tttttctttt tctttcttgt 1370461 ttttctcttt ctcttctttt tcctttttca cttcatcgat gccgtctgac tcgttttcag 1370521 gaggagtgac actggagtag tccagtacac cggttccgcc tgtaaaaact tcattaaatg 1370581 attttgagag catttgaaac ttagctgcgt caatcgagct gctcgcgtac agcacaataa 1370641 acaatgccag gagaagagta aggatgtcgg cgtaaggaac gagccatgat tcatcaacgt 1370701 gctcgtcctc atgcttcttc ttcttttttc tcgccatttt gcgcctctcc ttgttctgca 1370761 aatttcaagc ggtccttcgc aggaagatac attaaaagct tttgttcgat gactttcggt 1370821 gcttgtcctt ctaaaacgga taaaacacct tcaatcatga cctcacgcag ttttacttcc 1370881 tgttttgatt ttcgttttaa tttatttgcg aaaggatgcc ataacacata ccctgtaaag 1370941 ataccgagaa gtgtggcaac aaaggcagca ctgatggcgt gtccaagctc atctgtgtta 1371001 tccatatgag agagagcggc aatcagcccg attacagcgc cgagtactcc aagtgtcgga 1371061 gcgtacgttc ctgcttgtgt aaaaatagcg gctcctgctt ggtgcctgtc ctccattgct 1371121 tcgacttcct ctgtcataat atctcttata aattccgcgc tttgcccgtc aacagccatg 1371181 ctgagcccgt ttttcaagaa agcatcatct acatcctcaa tgcttgcttc taaagcaagc 1371241 agaccttcgc ggcgtgcaag ctgagcccat tcagagaaca taggaatgag ttcctctatt 1371301 gtgagctgtt tattttcctt aaataacact cgaaacagcg taggcacttt tttaatttct 1371361 tttgttggga acgcaataac gactgctgag attgtcccgg cgataataat taaaatggca 1371421 gcggggtttg caagggcgct gaaactgacg cctttcagaa ccatcccgac gctcaatgcc 1371481 acaaaagcaa gaataatacc gattaacgaa gttttatcca tagttttcac caaatccttt 1371541 tttactagct tgtctatggt taatatcggt tttggtgccc ggaactttag ggacattgtg 1371601 aatttgttca tgaaatattc aaggaagagg catagaaggg agaaataaac aaaaacgggc 1371661 tctccaaaat tgaaaagccc gggggtctac tgaaattagc agcttgcttg caagctgtcc 1371721 ttcagatggt attcatataa tagtagaaat acatattcac tgtatataaa catgttccat 1371781 ccctccttaa aaaagtgtaa aggatgaagg gaagtagcgc ttcaggagaa gggacggtaa 1371841 tttctaagtc aagagtatga aagtataaaa aaaagcggct tcctaaaagg aaaccgctga 1371901 ttgttatttt gctcgcactt tgattttatc atcttctaaa atcacgtgaa aacttgtgat 1371961 ctcgccatta tcaagcagca gatcggtcat ttcatcctca acccattctt ggatggttct 1372021 tctaagcgga cgtgcaccga atgaagggtg gtagcccagc tcagcgattt tttctttcgc 1372081 ttcatctgtc acattcaagc taatgccccg ttccgccaat gtttcttcaa gttctccaag 1372141 aagaaggctg acgattttga caagatgttc tttttccaat gagcggaact caataatgct 1372201 gtcaaaacgg ttgaggaact caggtttaaa gaacatgctc agtgaatcaa ttaatgtttg 1372261 ttcttcgatg acactgtcat ctgattggaa accgactttc gtttgtttct caccagcacc 1372321 cgcattactt gtcatgatga tcacagtgtc tttgaagctt acagttctgc cttggctgtc 1372381 tgtcagacgg ccatcttcca taatttgcag gaacatatgc tgaacgtctg ggtgtgcttt 1372441 ttcaatctca tccagcaaca caatgctgta aggattgcgg cgcaccttct cagttaattg 1372501 tccagcttcc tcatggccga catatccagg cggtgaaccg ataattttag atacggcgtg 1372561 tttctccatg tattcgctca tatcgagtcg gataatagcg tcttttgtgc cgaataattc 1372621 atctgccagt gttttagaaa gctctgtttt ccctacgccg gtaggaccga cgaagaggaa 1372681 ggagccgact ggtctgtttt tggattttaa tccggcgcgg cttcgtctta ccgcttttgc 1372741 cactttttga acagcggctt cttgtccgat cacgcgttca tgaagttttg cttcgagttc 1372801 tttcattttc gtttgttcgt ctgcctgcag tttgccgaca gggatgcctg ttttttgttc 1372861 aacaatttcc tgaatgtgct cagcttccac agtgacagcg gtatgagcgg aggagctgtt 1372921 cagttttttc tccaatgcga gttcttcatc acggagtttt gccgccagtt cgtaattttc 1372981 ttcttccagg gcttttgttt tttcggcttc aattgcagtt aagcgttcag cggcatcctc 1373041 atcattcagt tcatcaatta acaggttggc ttttgaacct gcttcatcta ataaatcaat 1373101 tgctttatcc ggcaggtgtc tgtcctgaat gtagcgggat gataaagtga cacatgcttt 1373161 gattgcttca tcactgaatg ttacgccatg gtacgcctcg tatttgtctt taatcccttg 1373221 cagaatgagg atagcctgtt caattgaagg ctcctgcacc atgacaggct gaaaacgtct 1373281 ttccagcgcg gcatcttttt cgatttgacg atattctttc agtgttgtcg cgccaatgac 1373341 ttgcagttcg cctctggcta gggccggttt gagaatgttg ccggcgtcca ttgatccttc 1373401 tgcagagcct gcgccgacga gaaggtgaat ttcatcaatg aacagaatga cattttttcg 1373461 ttccttcagc tcagtgatca gctgtttcat tctctcctca aattggcctc tgatccctgt 1373521 gtttgcaaca agagatgcaa catcaagcaa gtatagctct ttgtttttta gtttgtttgg 1373581 aacatcacct tcagcaattt ttaaagcgag cccttcagcg atggcagttt tccctacacc 1373641 cggctcacca ataagaaccg gattgttttt gtttcggcgg tttagaattt cgatcactcg 1373701 cgccacttca tcatcacggc cgatgacggg atcaatgaga ccggcttttg caccgtttgt 1373761 aatattttga gccagctcat caagcaaccc ttttttttcg ctttgttttg ctgcgctctg 1373821 ttctttcggc tggaatgcct gttcaaacgg aaatccgaaa gattgaggac ccatactcat 1373881 tgaaggttta cgggtcagtt cgttatagca agtttcacaa agaaccatct gtttatgaac 1373941 ggaatttatt tgcatgttaa ggcgaatcgt cgcctcgttt tgatgacaat gttgacaacg 1374001 catttgccaa aacctcctta ataatttgat catctttgac caatgaaagt gaataaaaag 1374061 gtctattggg tttgaccttc tttgactatt agtatacggc aaacttaacg gcattcaaac 1374121 caatatgctc aaagcagact gaatatttga ctatctttga ccaattgatt tttaaaaaag 1374181 gccggtttgt ttgaccaact ttgattaata gtatactctg actatctttg actttcaagt 1374241 cttatgcaca aaaatttttg atttgttaca aagtaaaaca tgttttcttc gtcttttcaa 1374301 ggaacttgtc tcataggtta taaaaaggca tatatggaca aaactgcggt tcgttcggag 1374361 ggaagaaatg gaacaatcaa aagggtctgc aagtcagctt gcttttgtgt atgtcggcac 1374421 agtagtcgga gctggatttg cgactgggag ggaaattgtt gagttttttc tgaagttcgg 1374481 ctggttcggt tttttcggca ttctcgtcag cggcggaatg tttacgttac tgggggccaa 1374541 gctgatgatc atttcaaagc gaatcaatgc caagtcatat caagaaatga acatattttt 1374601 gttcggggcg acggctgggc ggattatcaa tgtatttatg ctgtttgttc tccttggagt 1374661 tacatctgtt atgctttcag gggcaggggc gctttttgag gaacagctgg ggatgtccgc 1374721 tcagattggg atgctcatta caatcggtct gagtttaatt gtgatgacta gaggagtaaa 1374781 aggcattttc ggtgtcaatg tgtttgttgt tcctctttta atcatctttt caatgattgt 1374841 ggtggccgac tcttttatat tcagcgaatc acgaaacgca gctcagtggg tctggccgca 1374901 tcgctgggat tggctgttat cagcagtttc ttacggggct ttaaatttat cgcttgccca 1374961 agctgttttg gttccgctgg cgaatgaaat gtcatcggag aaagtgataa aaaaaggcgc 1375021 tttaatcgga ggcacgatgc tgacgattgt gctgtccgcg agttttctgt ctttgtcgac 1375081 tcttccggat gtatttttgt atgatatacc gatggcgcaa gtggtttatc tctttgcacg 1375141 atctgtccat ttgatttatt tactcattat tttcggagaa gtgttcacat cagttatcgg 1375201 taatctatat ggattagaaa aacaagtgca aagctttctt ccagtgaaaa gcaaatatat 1375261 ctttgcagcc attatgatca cggcttatat tacgagccaa atagggtacg gcaggcttat 1375321 ttcaacgatt tatcccttgt ttggctatgt gagcctggcc ttcataggcg ctttgctttg 1375381 caaaaaagct cctcggcggc gcagtttata aatatatata atgaaacgaa ccgtcactat 1375441 agagcgataa ttgatctagg aaccggggac tgactttttt attgtcaaga aaaacatcat 1375501 tatggtaaga tagcagaagt gaaaaaattg aagaaaatcc gtgcgatatg cgggagaggt 1375561 tctagctaca ccctctataa aaaactaagg acgagctgta tccttggata cggccttttt 1375621 tatgtttttc tagagcacct tccgaaaaaa ggtgtttttt tgcgtgaatt agctgtagcg 1375681 atgtctctcg ccggcgtttt tattgcggag aaggagagga atcatgaaaa aagaaaaagc 1375741 aattgtcgta tttagcggcg gtcaagacag cacaacatgc ttactgtggg ccttaaaaga 1375801 attcgaagaa gtcgaaacgg tgacttttca ttataatcag cgacattcgc aggaagttga 1375861 agtggcaaaa tccattgcgg aaaagcttgg tgtgaaaaat catttgcttg atatgtcact 1375921 tttaaatcag cttgcaccga atgccctgac tagaaatgat attgagatag aagtaaaaga 1375981 cggcgaactg ccatccacat tcgttccagg ccgcaatttg gtattcttat cctttgcgtc 1376041 tatcctggct taccaaattg gcgcgcgcca cattattaca ggagtttgcg agacagactt 1376101 cagtggttat cctgactgcc gtgacgaatt cgtgaaatct tgcaatgtca cggtaaatct 1376161 ggcaatggag aagccgtttg tgatccacac gcctctcatg tggctcaata aggcggaaac 1376221 gtggaagctt gcagatgagc ttggcgcgct ggattttgtg aaaaacaaca cgctgacatg 1376281 ctataacggc atcatcgcag acggctgcgg cgaatgtccg gcatgtcacc ttcgttcaaa 1376341 aggttatgaa gaatatatgg tgatgaaagg agagcgtgca taaattgtta tctcaaattt 1376401 atccgcaggc ccagcatcct tattcgtttg aactgaataa ggacatgcat atctcagccg 1376461 ctcattttat ccctcgggaa agtgcgggag cgtgcagcag ggttcacggg catacgtata 1376521 ccgtaaatat aaccgttgcc ggcgacgaac ttgacgattc aggctttctt gtcaatttca 1376581 gcgtactcaa aaaactggtg cacggaaact atgatcacac gctattaaat gatcatgaag 1376641 atttttctca ggacgaccgg tattcgctgc cgacaactga agtcgtggcg aaaacgattt 1376701 atgacaacgt acaggcttat ttagacactt tggagaataa gccgacctgt gtacaggtgt 1376761 ttgtccgtga aacaccgaca agctactgtg tctaccgtcc gaaaaagggt ggtttgaatg 1376821 gctaaaggaa ttcctgtatt agaaattttc ggcccgacga ttcaaggaga aggcatggtg 1376881 atcggacaga aaacgatgtt cgtccggaca gccggctgcg attattcctg cagctggtgt 1376941 gactccgctt tcacttggga cgggtctgct aaaaaagata ttcgctggat gacggcggag 1377001 gagatttttg cggagcttaa ggacattggg ggagatgcgt tttctcatgt gacgatctca 1377061 ggcggcaacc cggctctgtt aaaacagctg gatgctttta ttgaactgct gaaggaaaat 1377121 aacatccgtg cagcgcttga aactcaaggg accgtttatc aggattggtt tacgctgatt 1377181 gatgacctga caatttctcc aaaaccgcca agctcaaaaa tggtaacgaa ctttcaaaag 1377241 cttgaccaca ttttaacttc acttcaagag aatgatagac agcatgctgt cagcttgaag 1377301 gttgtcatct ttaatgatga agatctggaa tttgccaaaa ctgtgcacaa gcggtatccg 1377361 ggaatcccgt tttatttaca agtcggaaat gatgacgtgc atacgacaga tgatcagtca 1377421 ctgattgcac atttgcttgg aaaatatgaa gcgcttgttg ataaggtagc tgtcgatgcg 1377481 gagctgaatc tcgtcagagt gctcccgcag ctgcacaccc tgttatgggg caacaaacgc 1377541 ggagtataat agaaaggaag atgaacatga cgacaagaaa agaatcagaa ttagaaggtg 1377601 taacattgct aggcaatcaa ggtacaaatt atttgttcga atatgcaccg gacgtgctgg 1377661 aatccttccc taataaacat gtaaaccgtg attactttgt aaaattcaat tgcccggaat 1377721 tcacatcttt atgtcctaaa acaggccagc ctgactttgc gacaatctac atcagctaca 1377781 ttcctgatga aaaaatggtt gaaagcaaat cattaaagct gtatctattc agcttcagaa 1377841 accatggtga cttccacgag gactgcatga atatcatcat gaacgacttg attgaattaa 1377901 tggacccgcg ctacattgaa gtatggggca aattcacgcc aagaggcgga atttccattg 1377961 atccgtacac aaactacgga aagcctggca cgaagtatga gaaaatggcc gaataccgta 1378021 tgatgaacca tgatttgtat ccggagacaa ttgataatcg ttaattattc cgttgtgtga 1378081 tacggagtgt aaaaggaagt ggagtcacag taaaatccga acattcagcg ttaattttca 1378141 gcggaaatgt gacctggtca cagcgaagtg tgacccgcac taagctcaat aaaagtggga 1378201 aaagtcacac ctgaaaatgg ctctactcat gggaattgta ttaaaaagtg tgacctgagg 1378261 tgcaacctga actgtgactt ttatgcagtg aaaaattgat agtacagaag cagattaagg 1378321 cgtacaattt gtacgtcttt tcttttttat ccgaaagaaa aaatgcctat ctagagatca 1378381 taggcattaa atattattat caatatcttc atttattttt tggctaagtt tctgaacctt 1378441 ctctttaaca tttgaaacag ctcttttttg aatttcatca attctcctga atatagtcga 1378501 tgacacttct tattagaact tcactttcaa aattgaatat ctcatttatt tctgactgtt 1378561 cttcatctgt taggtgatgg tattgaagtt gtttagcatt tacttcagca gctacatcaa 1378621 tcctaactta gttgttctgg ttgtacaatt tcatattcac cttctgcata ctcttgctcc 1378681 gcataatagc ctccccattg acagagctcc tgcaagatag gtttaagaga ttctccaagt 1378741 tcagtggatg aatattcaac cttcggcggt acttgattat acatctttct gctcacaagt 1378801 ccactggctt caagctctct aagtgtttga atcagcattt tctgagttat atttgggata 1378861 atgcgcttta attcactcgt tctctttggt ccattcatta aaaagtataa tacaaggcct 1378921 ttccattttc cgccaataac ttcctttgtc acttcaaacc cacagctaaa ttttttcatg 1378981 tctaaagctc tccattccac atttattact ttttagttac tatatcacaa aaaagtgggt 1379041 acttccgata atgtgcttac tgaaggatac tatatcttgt aagttgttct tcaagtactt 1379101 aaaggtacta gacataaaat aaaattaatt ctaaaggagt gttaagtatg ggtaaatttg 1379161 aaggtaaaat agcgcttgta acgggtggaa caagtgggat tggtcttgct acagcacaaa 1379221 aatttgtaaa cgaaggtgca tatgtttata ttacgggacg tagacaaaac gaacttgata 1379281 aagctgttaa ccaaattggc aagaacgtaa ccggtgttca aggtgatatt tctaagcttg 1379341 aagacttaga caaactatat gacattataa agcaggaaaa aggtaagttg gacattcttt 1379401 ttgctaatgc aggcatcggc aacttccttc cattaggtga aattactgaa gagcaggttg 1379461 atagaacgtt cgacattaac gttaaaggaa ccatctttac tgttcaaaaa gcgttatcac 1379521 tattcccgga caaagtaggt tctattattg taacgggctc tactgctgga tcaattggca 1379581 acccagcgtt tagtgtatat ggagcatcta aagcagcatt aagagcacta gttcgcaact 1379641 ggattcttga cctaaaaggt actgaaatcc gtgtaaatgt ggttagtcca ggaggtattc 1379701 ttacacctgc ctacgatgag ctttttggtg atgcacttga agaggtactg gaaaatagca 1379761 gaaatactgt tccagctgga aaagttggga cacctgaaga agtagcaaac gctgtatctt 1379821 tccttgcttc agacgaaagc agttacttga cgggtgttga attgttcgta gatggcgggc 1379881 tagcacaggt ataatttcac tgcgcagaga ttacaaatag tccccaaaaa aggttaatgg 1379941 ggatttactt gaagaagtcg tataaaaaag tcgttttcct taaaggacag ggaattcgac 1380001 ttttttatat ttgaatttga ttaacgttgt aaattcgcat tttcctgggg ctactactaa 1380061 atgacctgta aaaaagatta cactgtgaat aaatgtactt aaagtaacgg gggctcttga 1380121 cttttaataa aaaataatat ccctgtcctt gtattctaat acttttaaaa atatttaaag 1380181 gaatccttat gtcctgaata accacatagg aaaatatgtt gtaggttgct ttcttttttt 1380241 gtggggcatc ccacacaagc tatctcgtga tctcacacct gaacgttttt tatagactag 1380301 taccgcgaca agttatatta catatacata ccaataaagt agacattaaa aagtgaaaga 1380361 gaggatggaa atgtgtgaaa attcttttcc ttgagagtca tcccatgtgg ctctatggtt 1380421 taccgaatgg gtttagggaa gcaggacata ccgtaatgat ttccggtcct gtaagtcggg 1380481 aaaatataac tgaaatgata gacgaattta aaccagattt aatagtatct atgggatgga 1380541 caccagagca ttcaagggaa aagcaggcct ggattcgcaa cgctactaaa aaggtgaata 1380601 tccctctcgt ttattgggca actgaagacc cgctgcacac tcaaaacttt actatcccgt 1380661 taattaaaaa gatgaaaccg gattttgttt tcacggtcac gccttctctg tgtaaaactt 1380721 atgaaagcat ggggattaaa gcagctcact tagactttgc atttcacgaa agtatacatc 1380781 accagattaa accattagcg aaatacagtt gtgatatagc agtggtggct aatgcttacc 1380841 ctaattttct tgaagaacat ccggaagtgt tccgttcgtc ctctttaaaa acgcttattc 1380901 gtcctcttat acggaagggt attcgcattg atttttgggg gagaaactgg gaaaaaatga 1380961 gtaaatatat aggaagagaa attccccgca attggatcca tggatacctt gattatactg 1381021 aagcatataa agtttacagt tcagcaaaaa tcattatcgg tttgcaaaac tgtgaaagcc 1381081 aacttacaca acgcacctat gagattcttg gttccggggg gtttttattg acatcggata 1381141 caccagcagt tcgaggtaaa ttcaaacctg gccgcgatct catcgtttct tcctccccaa 1381201 aagaaacatt ggaaaaggtt aaatactatt taaatcatga tagcgagaga aaaaagattc 1381261 agataaacgg taaaaaggct gtaaagaatg attcctatcg gcatagagcc gagagaatgc 1381321 ttgaggtgct aaaaagcaga ggaatcataa gaaacttagg ggaaaccatt cattatgtag 1381381 atgttctcaa agaaaaatac gtgatccatc atgttactcc cggtgaaaca ttatcaataa 1381441 ttgccagtaa gtataatgtt tccctgcagc aactcatgga gcttaatcat ttcaaatcag 1381501 atcaaatata tgctggacaa atcattaaga ttagagagaa actgtttaga aatattaata 1381561 acaaattatt ctaaaggaga gtaatatgaa tgaaggggaa aatacctaaa ataagaaatc 1381621 aagcgaataa agtaaaaaga acgcctcgtt atatggaatt tcccgtgaca tacgaagtat 1381681 atcatgtgga atccggcgat acattatgga cgattgccaa atcctttgaa attccggtac 1381741 aacaacttat gaatcttaat aagctttctt cagatagaat ttatcctgga caaattataa 1381801 agataagaga aagataatct ttgaggtttc ggaagcgaat caaattgaaa tgacaatcct 1381861 cattttttta tttgtgggga acttgatatt tttggggatg aaggggttat gagatgtttc 1381921 aaatgagcta ttactattct ggattaggat gggactttat tcaacacgtt gatcaaacga 1381981 acggagtatt aaatgttgtg tctcctgatt ttttctatat cagaaaagat ggatcattac 1382041 ttctccgttc agctaatccc gatgtgatta aagctcttca tagaagaaaa ttaaaagtag 1382101 ttccttttct aagcaatcat tgggatcagg atttgggacg atttgcatta atgaaccgag 1382161 ttcttttagc taaacaaatt tctcatgcaa tagaagaact ggatttggat ggagttaata 1382221 tcgatataga aaaccttaca gaaaaagatc ggaatctatt tacagatttt attagattag 1382281 taaggaaaag tattcctaga cataaagaag tatcagttgc agtggcggca aatccttttg 1382341 gctggacgaa gggctggcac ggatcatatg attacgagta tttagctaaa tatgcagatt 1382401 atcttatggt tatggcctat gatgaaagcc gccttgctgg gcctactgca agtgtaggat 1382461 gggtggaaaa gtccattcaa tatgttctga cccaaaaaat ctctcctcaa aaactagttt 1382521 taggattgcc attctatggc cgctgctgga tggaaggcca atctgcctct caagccattc 1382581 ccctttacct tgttgttagt aaaaaggcat agcgggacaa ttatttttga caccaagagt 1382641 caatctccaa aagctatttt tactgtcaat cacgataaaa aggggccgtt gccttcggga 1382701 acatatacat tatggtttga aaatgaacag tcactcagag caaaaataaa actcgctcaa 1382761 aaatataatc tgaaaggtct tggcagctgg agtcttggac aagaagatgc gtcagtctgg 1382821 aatacagtgt ttaaaaatat ataatgattt atagttcaga acaaaattcg aagataattg 1382881 caatgaatct ctaaatggac atactgaaag gagtttatta cgagtgcggg taaaacagtg 1382941 agggcattcc ataggccctt ctcccaaaat gttctacacg aggcattaca ttgggcttga 1383001 aatacacatt caaacttatg ttatagtacg cattttacgg atgtgttgaa tttattctgc 1383061 ttccatgatt taatcataca catgctactt gatagcaggg ttatcgcatt tcattcagaa 1383121 ttgttcagga tcgatatgga agcgcacgac taactagaac tttaaaagca tacactcata 1383181 tacttcctga atggatgctg gtttatctaa aaaacatgat gagaattgat tgtacgcatg 1383241 gtgaagcatg acttgttgat aatcgaccat atggtttctc cttagaaatg agggggtttt 1383301 tacataaaaa agacgagcga atccgggggg aattccactc gccgctttct aatgaaaaga 1383361 cgggatgctg gatggcagct cgtctgtttt attataattt aacgaacgta tgtttgtaaa 1383421 ggtgtctttt cgaatgaatt ggttcatata accgttaaga acagattcat tgtaaacatt 1383481 cgctaaggta tgctaagatg catggactat aaaggagtga tatgaagtga agacattgcg 1383541 gttaaacaat gtaacgttag aaatggctgc atatcaagag gagagcgagc cgaagcgaaa 1383601 aattgcattt accttaaacg ttacgagtga gacttaccat gatatcgctg tcctgttgta 1383661 tgaaaaaacg tttaatgtcg aggttccgga acgcgatctt gccttccggg gggaaatgac 1383721 aaattattca acatcattga ccaacctgta cgaaccaggg gccgtcagcg agttctatat 1383781 agaaataacg gaaatagaca aaaacgccga ttcatgatcg gtgtttttta tgtaaaaaag 1383841 ctgccggccg gcagcttttg agaaagcgaa tttcatatgt aaggtgttaa attgtccgtc 1383901 ttgcagtttt ttgaataaat gtggaaataa ggaggtttta ataggagtct ctgatgatct 1383961 tataattttt atgattaaca actgtcaatg aatctaactc aagatcccga tagttatcca 1384021 tgatcgtcac atcaacgata acagaattct catttacttt ttcaacaaca ccggttaatc 1384081 cgtttttaaa ttcaatgaca ttcccaacct tagcgatttt cacaagcttc ctctccttta 1384141 aacataataa tgccttttga aagtattttg cagtattttc attgagaagt aaagcgataa 1384201 ggagttttat ctcccttatg aattgttctg tcgctataaa gatgatatat tgattttcgt 1384261 caatagaaag aaaagggggg aatttttgtt gcgtcccgaa gaaataacag aaatgattga 1384321 acagctgcgc accggcgcca taaacgaact gagagtccag aaagagcatt ttcttgattt 1384381 cagggccgtg ttatctaaac aagatgattt taaacatttc cgaggaattg cccagcaagg 1384441 cggagatgtt atctttcaat acttagaaca gccaagaagc tgaaggtttc tcatacgtga 1384501 gaagcctttt tatcatatat gacagaacac aagcctttta ttacagctgt ctgtaacagg 1384561 tgtaaataaa atgtaaagta ccaaagatgg ataaacatgt tttaatttaa caatatttat 1384621 agaatttcag actgtttttt tgccattaag cagtgagtca tcctctttat tccatcctga 1384681 tacctccttg ggagagttgg aaaatctttt tccgtgaaaa tgaatggatc tcttgttaag 1384741 gttatgaagt gttttttgga gcactttaag gaggaaactg tatgacaacg aaattcactg 1384801 ctctggctgt ttttcttctt tgtttcatgc ctgcagccaa aattgagcat acacaagctt 1384861 cactactgag cgcaaagaag acaaaacatg aagaagcgaa atggcttaca catatagatc 1384921 gaaatacgaa tgaatctttc ccttcactgt ctgctgataa agacaagaaa ataaaaccga 1384981 ttaagctatc agcacacact gaaaagaaag agaaagataa accggacaaa acaaatgatg 1385041 agaaagaaac atatacacag tctgaaaaag agttgctgtc ccgtctcgtt cacgcagagg 1385101 ccaaaggaga atcatataaa ggcaaggtcg ctgtagcaag cgttgtactg aacaggacgg 1385161 agaaaaaagg ttttcctgat acgataagag gagttattta tcagaaaaac gcctttgaac 1385221 cggtcgcaaa cgggagcatt aaccaaaagc ctgataaaga atcgattgaa gctgccgaag 1385281 aagcgctgtc ctcaaaaaat agagaaacag atgccatatt cttttataat ccgaaaacag 1385341 cgtcagataa ttggattcgt tcaagaaaaa tcgtagaaaa aatcggcaga cacgtttttg 1385401 ccgtctaagc atagaagaga caatttgtct cagctgtgct ttttttcata taaagagtaa 1385461 aaataaaata atttttgaac ttgtctcata tgatgttggt agtacaagag acaaggagag 1385521 acatcatgaa tcgatttgtg aaagggatca ttcttttatc cattgccgcc tttttcgctg 1385581 aatgccttga atttgtcgtc aatatgattt tggcgcggga gcttggcgag catgggatgg 1385641 ggctttacat gagtattttg cccacgatct ttttaattat tgtcatcgcg agcctggaac 1385701 tgccgatatc catttctaaa ttcattgccg agtcaaatcc taagcttcat gaaagcatgc 1385761 tgaggcacgc tttcagaatg acagccattt ttactgcttt ttctactgcc gccgctagta 1385821 ttgcgcttcc gtttattccg gtatttgata cataccaccc gtttattaaa gggattgtca 1385881 tcggcttaat tcctgttgtc gcctttactt caatcgccag gggctacttt atgggtgtgc 1385941 agaaaatggg gaagatcgca attgccaatg tgctgaaaaa aatcatccag ctcttgtgct 1386001 tattcctctt ttttcaatgg tactcatttg aattggacat ggctgtgctg atttccttgt 1386061 ttgttctagt cgtgagtgat gtggtcgtgc ttgtttattt atattcacaa tttatcatgg 1386121 caaggcgggc gttatccggc cagcagcaca ttcatttgcg cggaaaggat gtaaggaaaa 1386181 gactgcttgc tgtttcaatt cctacaacag gactgcgtat ttttcatgcg gttgtcaatg 1386241 caattgaacc ctttttagta aaaggagctc ttttggctgc gggcgttgcc gggacagcgg 1386301 cgatcgatca atacggaatg ctggcaggag tggctgtgac gatagggtcg ttccctgctt 1386361 ttattgccca ttcgttaatg gtcgtcatga taccgagtat ttcggaagct tatgcacttt 1386421 ctcagtatga catcgtgtta aaaaggctga agcagtcgat tttcattaca ttaggttacg 1386481 gtatacctgc cgtctgggtc atgttccagt ttgcgggacc tctcacgcat ttgttttttc 1386541 actctcctga agcgcagtat tacttgcagc tgttgtggcc ttactttctc tttcatctgt 1386601 ttgtcatgcc gctgcaggcg tgcttaatcg ggatgggttt tgtgaaagag gctttttatc 1386661 acaatgtatg gagccatatc gttgcgctaa gtatgatgta tgtactggga tcaatggaga 1386721 atctgcaaat gctcgggatt atccttggaa tgaacactgg catgattctt ttgacgagcc 1386781 tgcactatgc cacgatctgc aaagcattga aggtatctgt atttcttacg ggagggacca 1386841 gaacgccgcg aattgaagga tgataaagga acagcagggg caagctaatt gaaaagcatg 1386901 aaaggaagat tccatgttga cgaagcgctt gcttactata tacattatgt tattagggtt 1386961 gattgcatgg tttccaggtg cggcacaagc tgaggaaaaa cagcctgctg ttcccgctgt 1387021 ttttcttatg aaaacgatag aaggggagga catctcgatt ccgaataaag ggcaaaaaac 1387081 aattctccat ttttggacgt catggtgccc gccctgcaaa aaggagcttc cacagtttca 1387141 atcgttttat gatgcccatc catccgacag tgtaaagctg gtaacggtga atttagtgaa 1387201 ttcggaacaa aatcagcaag tcgttgaaga ctttattaaa gcaaacaagc tgacgtttcc 1387261 gattgtcctt gactcaaaag gggaattgat gaaggagtat catatcatca cgatcccaac 1387321 atcatttttg ctgaatgaaa agggagaaat tgaaaaaaca aaaattggcc cgatgacagc 1387381 ggaacaactg aaggaatgga cggaagaata gctgagagca tagactctca gcttttttca 1387441 tatagagaag aagtgaataa acattaatga taattattat caaaaagaaa ttaaaataat 1387501 tataattgaa attctcttcg tgcgtgctat aataaaggaa gacatcaaga aataactgac 1387561 gataaagctg ccttttgggc agcgattttg tttttataag agaaatgaag atgatttacg 1387621 ttctcaatta gagaggagaa ttcgatatga atgaacaagt tatcgttcaa cgcgacccgc 1387681 atgagccatt gaaaacagac aagagggaaa aaaactgggc acagcacgcg gagcttattg 1387741 cagcacttgt atcaggcgct cttattttgg caggctggct cttatccgga tatcaggtat 1387801 tatccataat acttttcttg ctggcttttg tgatcggcgg atttgctaaa gcgaaggaag 1387861 gaatcgaaga aacactcgaa tccaaaacgc tgaatgtaga acttttaatg attttcgctg 1387921 ccattggttc cgccttgatc ggatactggg cagagggtgc tattttaata tttatttttt 1387981 ccttaagcgg agctttagaa acatacacga tgaataaaag cagcagagat ttaacgtctt 1388041 taatgcagct tgagcctgaa gaagcgacat tgatggtcaa tggtgaaacc aaaagagttc 1388101 cggtttcaga cttgcaggcc ggtgatatga ttgtgatcaa acctggagaa cgcgtagcgg 1388161 cagacggtat cattgaatcg ggctcgacaa gtcttgacga gtcggcttta acaggtgaat 1388221 caatgcctgt agaaaaaaac acaggcgaca ctgtattcac aggaacggtg aatcgcaatg 1388281 gctccttgac agtccgtgtc acgaaagcaa atgaagattc gttattcaga aaaattatca 1388341 aactggttga atcagcgcaa aatagtgttt cacccgcgca ggctttcatc gaacgatttg 1388401 aaaatgctta tgtgaaaggt gtgctaattg cggtggcgct ccttttattc gtcccgcact 1388461 ttgcgctggg ctggagctgg agtgaaacct tctaccgcgc aatggtgttt atggttgtcg 1388521 cgtcaccttg tgcgcttgtc gcctctatta tgccggcggc gctgtccctg atttcaaatg 1388581 gcgcccgcaa cggtatgctt gtgaaaggaa gcgtctttct tgaacagctg ggctcagtgc 1388641 aaatgatcgc ctttgataaa accggaactg taacaaaagg ccagcctgcc gtagagacga 1388701 tcagaatagc agaaggattc agtgaagcgg aagttcttga ggctgtctat gccatcgaaa 1388761 cgcaatcaag ccatccgctc gcccaagcca taacggcgta cgctgaaagc cgcggcgtga 1388821 atcagtccgg ctacatatct atagaagaaa cctcagggtt tggcgttatg gcagaagtgt 1388881 cgggtgcgaa atggaaggtc ggtaaagcag gttttatcgg cgaggaaatg gcagcacaat 1388941 ttatgaaaca aacagcatca gatgtcattc aaagcggtca tacaattgta tttgtgaaaa 1389001 aggatgatca aatagcaggc tgtatcgcac tgaaggacca aatcaggcct gaagcaaaag 1389061 aggtcatgga agaactgaac cgacttggga ttaaaacggc catgctgaca ggagatcacg 1389121 aagacacggc tcaagcgatt gccaaggaag ccggcatgac aactgtcgtg gcagaatgcc 1389181 tgcctgacca aaaagtgaat gaaatcaaac ggttaaaaga agaattcgga acgattgcaa 1389241 tggtgggtga cggaatcaat gatgcgccgg cactcaaagc agcggatgtc ggcattgcga 1389301 tgggcggcgg aacagatgta gcacttgaga ccgctgatat ggtcctcatg aaaaacgatt 1389361 tgaaaaagct cgtaaacatg tgccgcttgt ctcggaaaat gaacaggatc atcaaacaaa 1389421 atatcgtgtt ttctctagct gtaatctgcc tgctgatttg tgcaaacttt ttgcaggcga 1389481 tggaattgcc atttggcgtg attggtcatg agggcagcac gattttagtc atactaaacg 1389541 gtttaagact cctaaaataa aaccagcagc ctaatcaggc tgctggcttt ttatgtatca 1389601 agctttccct tcatttttgt ctttatcaga tcttttcata actaggatga gagcgagggt 1389661 gcagcaaagg aaacccgctg cacagcctat gatagagctg taataataaa agcccaccat 1389721 cttcatcccg ataaaaggag cggaaattcc caaaaccgtt aagagcataa ctgcttttcg 1389781 tctgaaaaaa ttcatcagca aacggaacaa cccccctgcg attgaacgtt actgtcagta 1389841 tacaggaaga ggagcaggaa ataaaatgca ttagaaaatg aaggcgtcgt gaaaggcaaa 1389901 caccggtaaa acctgttaca atggaagaca gaacaatgca ttgcaaatgg cagggaggaa 1389961 caagaagtga atagaataca acgcgtctct tcatggctga aggaagcggg gcatactgcc 1390021 gcatttattc atacgaaaga aaatgttttt tacttaaccg gtttttacac agagccgcat 1390081 gaaagattaa tggggttatt tatttttcaa gaagaggagc ctttctttgt ttgtccagga 1390141 atggaagcag gacaggcccg caacgcaggc tggaatcatg aaatcattgg ctatgcggat 1390201 cacgaaaatc cgtgggagct gatagagaag gctttgaaaa agcgaaatat cagcatacat 1390261 atgcttgcgg tagaaaagga ttcaatctcg ctgtcacgtg cagaacagct gaagcatgcg 1390321 acgggcgggg ctcaatttgt ttcagcagaa gaaacactca atcaatttcg cctgattaaa 1390381 gatgacaatg agattcgttt gctgaaagag gcggcaaagc ttgcagatta cggtgttgaa 1390441 gtcggcacag ccgctttgcg tgaaggcatc agtgaagtgg aagtgctcgc tcaaattgag 1390501 tatgagctga agaaaaaagg aattcagggc atgtctttct ctacaatggt tttattcgga 1390561 gaaaaatctg gccagcctca tggaaatcct ggtacagcca cgttgaagaa aggtgatttt 1390621 gttttatttg atctcggtgt tattcttgat ggctattgct ctgatattac aagaacgttt 1390681 gcatacaaaa ccatcaatcc gaagcaggag gccatttacg agactgtgct tcaagcggaa 1390741 aaagccgcga ttgaggcaag caaacccggt gtgagaatcg gagatctgga tttaactgcc 1390801 cgcggaatca ttgaaaaagc gggatatggt gattattttc ctcaccggct tgggcatgga 1390861 ctcggaattt cagtccatga gtatccatca atgagccagg ccaacgatac actgctgcag 1390921 gaaggcatgg tctacacgat cgaaccgggg atttatgtgc cagagatcgg cggcgtacgc 1390981 attgaggatg acgttcacgt aacaaaggac ggagcagttg ctctgaccca atatccaaag 1391041 gatttgatca tactgtaata gaaataaaaa aggactttgt tctcgacatc gtcctttttt 1391101 atctgcatta aataaaaaaa tcatcaaatg ttcgaaaggg tttaatttca tgtttttggt 1391161 tgagaggttt tacagcaaga cagctgccac cgagaacagt gagacataac ccaattaaaa 1391221 tgaagaaacc catgtgatct tctcctttca gctaaaaaca caaaaagata tctggtacgt 1391281 ccatatcata ttgtatgaaa cgcattccag atcaagggga tttagaaaga agggaatcta 1391341 tggctaatat taaagacatt gcagagaaag ccggtgtctc tgttacaacg gtttcccgag 1391401 tcataaacaa tcatccatac gtcagtgaag acaaacgaaa aagagtgttt gaggcaatgg 1391461 aatcattgga gtacacgaga aatattcacg ctgtacattt gtcgaaagga ttttcaaaca 1391521 tgattggtgt tgtcttgccg acggttaatc tgccatattt tgcagagctg attgcaggaa 1391581 tagccgacgc agccgcggaa tccggggttc acctctcttt attccaaaca aactatgaag 1391641 tacaaaaaga aatctttgcg ctgtcccaat taaagcagcg ccaggttgac ggcctgattt 1391701 tttgctcaaa ggcgcttgct gatgagaaac tcatggaatg ggagggcccg attttgcttt 1391761 gccagaattc agataatgcc cgcttcccaa ccatcagcat tcctcaccaa gaagcatttc 1391821 ggaacggctt ggactattta attgccaaag ggcacaaaaa aatagccatc tgtttggcaa 1391881 gaaaaaaagg catgaacagc cattttcgaa tcaaagccta caaagaggca ttggaagaga 1391941 tcggcgaggc atttcgtgaa gactgggtaa ttgagaaagc gattacaatc aatgatggga 1392001 aggcgctttt tcataaatgg aatacgtgga aggaaaagcc gacggctatt tttgttgcca 1392061 atgaccaagt ctcagcaggg ctttttcttg aagcaaagaa ccagcgggtg tcagtaccgg 1392121 atgagcttgc aatcttaagc gttgataacc acgaaatcag ccaagcgctt ggaatcacaa 1392181 cgatcgatat tcagacaagg gaaatgggaa agcaggcatt tgccatattg gaaaaaagaa 1392241 ttcaaggaca gccgattgaa aggaaagttc tggattaccg tctcatcgaa agatcgactg 1392301 tttagtgaat gcattgaaaa aaggtttgac gtgcattctg ttcgttatgt acgatatgag 1392361 gtattgaatg acaaaggagc tgaggatcgt gaatgggtcc ttcacagtga aaaaggtact 1392421 gaataataac gtattaattg cttctcatca taaatacagc gaagtcgttt taatcggaaa 1392481 aggtattggt ttcggaaaaa aacaagatga tgtcattgaa gataaaggct acgataaaat 1392541 gttcatttta aaagacgaga aggaacaaaa gcagtttaaa aagctccttg actatgttga 1392601 tgaaaagctc gttgatattt caaacgatgt catctatcac ataagcaata ggacgaatca 1392661 ctcattaaat gaacatattc acattgcgtt gacagaccat atcgcatttg cgatcaaaag 1392721 gcagcagcag ggatttgata tgaaaaatcc atttctaatg gagactcagt cactatatcc 1392781 tgaggagtac caaattgcca aagaagtcat agatatgatc aatgaaaaag cgggactctg 1392841 ccttccggaa ggggagattg gttttatcgc tctgcatatc cattcagcgt tgacaaaccg 1392901 tccgctgtcc gaggtcaatc agcactctca gctcatggcg cagcttgtcg aggtgattga 1392961 agactcattt caaatgaaag taaataagga aagtgtcaac tatttgcggc tgatcaggca 1393021 tatcagattt acaatagaaa gaattaaaaa agaagaaccg actaaagaac cagaaaaatt 1393081 aatgttgtta ttgaaaaatg aatatccgct atgctacaat acagcttgga aattgattaa 1393141 aatcttgcag caaacattga agaaaccagt tcatgaggcg gaagcggttt atctgacgct 1393201 tcatctgtac cgattaacca ataaaatttc ataaattcag tttatcctta taacgtgtta 1393261 ctgattcgat caggcatgag tgattgaggg aaaaaaacgg gaagttcatt ctcgttcttt 1393321 tgcgcaccca attttgctca tgcctttttg ttgtgtaaaa gggcaaatgt aaacggttaa 1393381 actggaagac ttacgcctgt gaattcgttg tcatgatttt tagctgtaag gtcagactag 1393441 taaaaagagg aggtcaattc ttatgtttaa agcattattc ggcgttcttc aaaaaattgg 1393501 gcgtgcgctt atgcttccag ttgcgatcct tccggctgcg ggtattttgc ttgcgatcgg 1393561 gaatgcgatg caaaataagg acatgattca ggtcctgcat ttcttgagca atgacaatgt 1393621 tcagcttgta gcaggtgtga tggaaagtgc tgggcagatt gttttcgata accttccgct 1393681 tcttttcgca gtaggtgtag ccatcgggct tgccaatggt gatggagttg cagggattgc 1393741 agcaattatc ggttatcttg taatgaatgt atccatgagt gcggttcttc ttgcaaacgg 1393801 aaccattcct tcggattcag ttgaaagagc caagttcttt acggaaaacc atcctgcata 1393861 tgtaaacatg cttggtatac ctaccttggc gacaggggtg ttcggcggta ttatcgtcgg 1393921 tgtgttagct gcattattgt ttaacagatt ttacacaatt gaactgccgc aataccttgg 1393981 tttctttgcg ggtaaacgtt tcgttccaat tgttacgtca atttctgcac tgattctggg 1394041 tcttattatg ttagtgatct ggcctccaat ccagcatgga ttgaatgcct tttcaacagg 1394101 attagtggaa gcgaatccaa cccttgctgc atttatcttc ggggtgattg aacgttcgct 1394161 tatcccattc ggattgcacc atattttcta ttcaccgttc tggtatgaat tcttcagcta 1394221 taagagtgca gcaggagaaa tcatccgcgg ggatcagcgt atctttatgg cgcagattaa 1394281 agacggcgta cagttaacgg caggtacgtt catgacaggt aaatatccat ttatgatgtt 1394341 cggtctgcct gctgcggcgc ttgccattta tcatgaagca aaaccgcaaa acaaaaaact 1394401 cgttgcaggt attatgggtt cagcggcctt gacatctttc ttaacgggga tcacagagcc 1394461 attggaattt tctttcttat tcgttgctcc agtcctgttt gcgattcact gtttgtttgc 1394521 gggactttca ttcatggtca tgcagctgtt gaatgttaag attggtatga cattctccgg 1394581 cggtttaatt gactacttcc tattcggtat tttaccaaac cggacggcat ggtggcttgt 1394641 catccctgtc ggcttagggt tagcggtcat ttactacttt ggattccgat ttgccatccg 1394701 caaatttaat ctgaaaacac ctggacgcga ggatgctgcg gaagaaacag cagcacctgg 1394761 gaaaacaggt gaagcaggag atcttcctta tgagattctg caggcaatgg gtgaccagga 1394821 aaacatcaaa caccttgatg cttgtatcac tcgtctgcgt gtgactgtaa acgatcagaa 1394881 aaaggttgat aaagaccgtc tgaaacagct tggcgcttcc ggagtgctgg aagtcggcaa 1394941 caacattcag gctattttcg gaccgcgttc tgacgggtta aaaacacaaa tgcaagacat 1395001 tattgcggga cgcaagccta gacctgagcc gaaaacatct gctcaagagg aagtaggcca 1395061 gcaggttgag gaagtgattg cagaaccgct gcaaaatgaa atcggcgagg aagttttcgt 1395121 ttctccgatt accggggaaa ttcacccaat tacggatgtt cctgaccaag tcttctcagg 1395181 gaaaatgatg ggtgacggtt ttgcgattct cccttctgaa ggaattgtcg tatcaccggt 1395241 tcgcggaaaa attctcaatg tgttcccgac aaaacatgcg atcggcctgc aatccgacgg 1395301 cggaagagaa attttaatcc actttggtat tgataccgtc agcctgaagg gcgaaggatt 1395361 tacgtctttc gtatcagaag gagaccgcgt tgagcctgga caaaaacttc ttgaagttga 1395421 tctggatgca gtcaaaccga atgtaccatc tctcatgaca ccgattgtat ttacaaacct 1395481 tgctgaagga gaaacagtca gcattaaagc aagcggttca gtcaacagag aacaagaaga 1395541 tattgtgaag attgaaaaat aagggtgtta gtacgccgtg cttgtcagat gacaagtacg 1395601 gttgtatgat ataatattgt gaagtaataa agctttaagt taaaaggaga atgataaaaa 1395661 tggcacaaaa aacatttaaa gtaactgcag attctggaat ccatgctcgt cctgcgacag 1395721 ttcttgtaca aactgctagc aaatacgacg ctgacgttaa tttagaatat aacggcaaaa 1395781 cagttaacct taaatctatt atgggtgtta tgtctttagg tatcgctaaa ggcgctgaga 1395841 tcacaatctc tgcttccgga gctgacgaaa acgatgctct taacgcttta gaagaaacaa 1395901 tgaaaagcga aggactcggc gagtaatgca agaattaaaa gggattggtg cttcagccgg 1395961 catcgcgatt gcaaaagcgt accggcttga agagccagat ttaacggttg aaaagaaaaa 1396021 catctctgat tctgaagcgg aagtaagccg ttttgatgaa gcgattgcac gttcaaaaga 1396081 agagctcgaa aaaatcaaag agcacgcttt gaaagaactg ggtcaggata aagctgatat 1396141 tttttctgct caccttttag ttctcagtga ccctgagctt ctgaaccctg tgaaagaaaa 1396201 aatcagcact gattcagtga acgctgaatt cgctttaaaa gaaacgtctt ctatgttcgt 1396261 tactatgttt gaatctatgg acaacgaata tatgaaagag cgtgcggcag atatccgcga 1396321 tgtaacaaaa cgcgtaaccg gccacctgct tggcgtcgaa attccaaacc caagcatgat 1396381 ctcagaagag gttattattg tagctgaaga cttaacaccg tctgacacag ctcaattaaa 1396441 ccgtgagttc gtaaaaggat tcactactga tatcggcgga cgcacatctc actctgccat 1396501 catggcacgt tctcttgaga ttccagcagt tgttggaacg aaagctgcta caggcacgat 1396561 ccaaaacggc gtgactgtta tcgttgacgg tatcaatggc gatgtcatta ttgacccatc 1396621 tgcggaaact gtaaaagagt atgaagaaaa acataatgct tatttggctc aaaaagctga 1396681 gtgggcgaag cttgtcaatg aaccgactgt ctcaaaagac ggacatcatg tagagcttgc 1396741 agcgaacatc ggtactcctg atgatgtaaa aggtgttctt gaaaacggcg gagaagcagt 1396801 tggcctttac cgtacagaat tcctttacat gggaagagat cagctgccta cagaagatga 1396861 gcagtttgat gcttacaaaa cggttcttga gcgtatggaa ggaaaatcag tcgtcgtgcg 1396921 gacacttgat atcggcggag acaaagagct tccttacctg cagcttccta aagaaatgaa 1396981 cccgttcctg ggatatagag cgattcgtct ttgccttgaa gagcaagaaa tcttcagaac 1397041 acagcttcgc gcgctgcttc gtgcaagtac atacggaaac ttgaaaatca tgttccctat 1397101 gattgcgaca gttaacgaat tcaaagaagc aaaagcgatc cttcttgaag agaaagaaaa 1397161 gctcgtaaaa gcgggacagg ctgtatctga cgatattgaa gtcggaatga tggttgagat 1397221 tccgtcaact gcagtcatcg ctgatcagtt tgctaaagag gttgatttct tcagtatcgg 1397281 aacaaacgat ttgattcaat acacaatggc agctgaccgt atgaatgaac gtgtatctta 1397341 cctgtatcag ccatacaacc cggcaatcct tcgcttaatt acactggtaa ttgaagcagc 1397401 acacaaagaa ggaaaatggg ttggcatgtg cggagaaatg gcaggagacg agattgcgat 1397461 tccgatcctt ctcggcttag gcttagatga gttctcaatg agcgcaacgt ctatccttcc 1397521 ggcaagaaca caaatcagca aattgtctaa acaagaagct gagtcattca aagagaaaat 1397581 cttatctatg agcacgacag aagaagttgt cgcgttcgta aaagaaacat tcaagtaatg 1397641 tacaaaaacc agacggcctc cggcctgtct ggtttttttc ataagtaagg gtatagaagg 1397701 acacaataac atggctagga gggatagtat gtcaaaccaa tttaacgcag gagatactgt 1397761 ttatgtgatc tacagaaatc cgcacgccgc caatgtagcc cacataaagg aagccgaaat 1397821 tgtgcaccat ccataccatg aaggcgagct ttccctgttt atttatgaaa cctatcatcc 1397881 attcgcagag gacgatgctg tgtttgcaag ctatgaagaa gctaaatcgc tttacaaaga 1397941 actgtttgat attgatccgt atgagtaaca aggaaatcat tacaactcat atcctttccg 1398001 cctagtgaga aaagtaacgt tagtaaagga aaaggatgtg gcatcatgca gaacccattt 1398061 gttccgcagc ttgtgtatat agaaccgagg gcgctggaat atccgctggg ccaagaatta 1398121 caagataaat ttgagaatat gggtattgaa atcagagaaa cgacatccca caatcaggtg 1398181 cgtaatatcc ctgggaaaaa tcatcttcag caatatcgca atgcgaaatc aactttagtt 1398241 atcggtgtcc ggaaaacatt aaagtttgat tcatccaaac cctcggccga atatgccatt 1398301 ccgtttgcaa caggctgcat ggggcattgt cattactgct acctgcaaac aaccatggga 1398361 tcaaagccgt atatcagaac ttatgtaaac gtcgaagaga ttttagatca ggcagataag 1398421 tatatgaagg agcgcgcacc agagttcaca aggttcgaag catcatgtac gtcagacatt 1398481 gtaggaattg atcatctgac acacacgctg aagcgcgcca ttgaacattt tggccaaagt 1398541 gatctcggaa agctccgatt tgtaacgaaa tttcatcatg tcgatcacct attagacgca 1398601 aagcataacg ggaaaacgag attcagattc agtattaatg ccgactatgt gattaaaaac 1398661 tttgagccgg gaacttcacc tcttgataag cggatagaag cggcagtaaa agttgcaaaa 1398721 gcaggctacc cgctaggctt tattgttgct ccgatttata ttcatgaagg ctgggaagaa 1398781 ggatacagac atctgtttga aaagctagat gctgctttgc cgcaggacgt tagacatgac 1398841 attacgtttg aattaattca acaccgtttt acaaaaccgg ccaaacgagt gatagagaaa 1398901 aattatccga agacgaagct cgaattagat gaagaaaagc gccgttataa atggggccgt 1398961 tacgggatcg gaaaatatat ttatcagaaa gatgaagagc atgcacttcg agaggcactt 1399021 gaatcctata ttgatacctt tttccctaac gcaaaaattg aatatttcac ttaaacgggc 1399081 tgttgtgatc aacagctcgc ttttttataa aaaacatttt tccattccat caaaacgccg 1399141 taattcaatg attctttatc ctccaaataa ttgctgacta cacgaatagg tgaacgcccg 1399201 caacggagga gaaaggacag cacagggtcg tttttcctgc cttccatcac atcttcaacg 1399261 tactgaacag cgctgatctc gtgtgcgtat ttataataca aaggaatgcg gccgccgccg 1399321 agaaggcgtt ccagtctttt atcaacagtc agctcataca tcgtattcat cagccatttt 1399381 ccgattccaa gctttcgata atgaggagaa acagaaatat ccactacata taaagtattt 1399441 ccatgaggtt catgattttt aatcgatccg ttgtcagttg cttgtgccca tgtatgatca 1399501 ggagaatcag gctcaaattg tacaataaga gcagtcatgg aaccgataat tctgccattg 1399561 atgagcgcgc ataaagcgcc ttccggaaag gttttgatat ggctggcaag ctggtcctct 1399621 gaccacagca attcctgggg aaacggagga gggaaacatt cttcttgaag agaaatcagc 1399681 ctctcgatgt cagtctcagt gtagtttcta atggtcagag cctcaaattt tctgccgtca 1399741 tgcacataca tttgttttag tatgatcatc actctcctta tgttgtttca ttataacgaa 1399801 gattgaattt tcagtaaata tattccgatt ttcttataat ttattttttg attattcatt 1399861 tttcaaacga aagggccgat atagaaatta ggaggggatt ggtttgttta aaaaacttca 1399921 catgaagatt gctgtttttg tttcgattat gttaatcatc acagttgttc tcttaatgct 1399981 gtcttcttat ttgacgctaa aaccgatgat tacagaggat gggaaaaata caactcaaaa 1400041 cgtgacgcag tcacttgaac aaaatattga attgcaatta aagagttatg ccatttcgtt 1400101 atcaagattg gctaatgggg aattaacgca tacatttgta acgaaaccaa gtaaagaagc 1400161 ttctcggctg tttcacgatg acattaagca aatcaaagac aacgatgatt atgttgcgat 1400221 ggcttacata ggcaccgcaa aaaaagaaat gtttacatat ccaaaagcgg atttcgctga 1400281 ggattacgat ccaacatcaa gaccatggta taagcttgca gctgaaaccc cggatcaagt 1400341 tgtttggacg gaaccttata aagatgtcgt gacaggagac atgattgtta ctgcatcgaa 1400401 agcgatctta gacaggcaaa aagtgatagg ggttgccagc tatgacttga aactctctgc 1400461 tatccagagt atggtcaata aacaaaaggt gccttacaaa ggatttgcct ttttagctga 1400521 tgcgagcggc aatcttttag cccatccgtc aaatcaagga aaaaatatat caaaggatca 1400581 aacactgcaa accatcgcat ccgagaaaaa agggatacaa gatgtgaatg ggaaaatggt 1400641 tgtgtaccaa acgattggcg agacaggctg gaaggtcgga acgcaatttg ataccgatca 1400701 attaatgtgg atttcagata aaatgaatcg ggccaatctt tggatatcat tgattgcgct 1400761 tatcataaca attattctca gctacttcct ggccaaaacg ataaccggtc cgatacagca 1400821 gctgatcgta aaaacgaaag ctgtttccgc aggcgattta acagtgcgcg cggaatcaaa 1400881 atctaaggat gaagtcggta ttttaacaag agatttcaat ctgatggttg aaaatatgaa 1400941 ggaaatggtt gagcaagtga gactctcttc agggaaagta tctgacacct ctgaacaact 1401001 aacggctgtg gctgccgaaa ctaatgaaac aagcggacaa attgcaaaag cgattgaaga 1401061 agtagccgca ggggcatcgg aacaggcttc tgaagttgaa accattaatg aaaaatcgga 1401121 aagcctgtca acgaaaatca ggcaaatcgc tgaggaggca ggcggaatta aagaacgctc 1401181 aaaatcgtcc gaggatgcaa gctataaagg acttgacgcg ctcggccagc tgctgatgaa 1401241 atcaaacgaa gccaatatgg aaacgaaaaa ggttgaaacg atgctgctgg atttggaaaa 1401301 tcaaactaag aatattgaag aagtcgttac agcgatttca aacatatctg atcaaaccaa 1401361 cttgcttgcc ttaaatgcca gtattgaggc agccagagcc ggagaaagcg ggcgcggttt 1401421 tgccgtcgta gccgatgaag tgcggaagtt agctgagcaa tcagcccttt ctacaaagca 1401481 tatcagcgag actgtgaagc ttatccagct tgagacaaaa gaggcctctc acgcgatggt 1401541 tgaggcaagc agaatgaatg atgaacaaaa cagtgcaatt cacgaaactg gagaggtatt 1401601 aaatacgata actgcagaaa tgcagtcact ggtacaaggt attgatcaca tttacgcgga 1401661 aattcaaaga atgagtgaag aacagcttgc gatttctgaa gccattcaaa gcatttcagc 1401721 catatcacag gaatcagctg ccgcagcaga ggaagtgaac gcatcaaccg atgaacagct 1401781 tgtcaccctt gataaagtca aacactcaac ggaaacacta aaacatgcaa gccaagagct 1401841 tatgaacaca attgcaaaat tcacattgta atccaattac atccccaaac atcatttgtt 1401901 ttggggattt tttattttat aagatgaata gatatggtag tctagaaaat gaaggaaaaa 1401961 tgataaattt taactaaaat ctaaacgaaa catctgggag gaatgacctt gaaaaaaaca 1402021 attggtttta tcggtcttgg agtaatggga aaaagcatgg catcacatat tctcaatgac 1402081 ggccatcctg tattggtgta cacccggaca aaagaaaaag cagaaagcat acttcaaaaa 1402141 ggcgcgatct ggaaagatac ggtcaaagat ctttcgaaag aagcggatgt tatcatcaca 1402201 atggtcggct atcccagtga tgttgaagaa gtgtatttcg gaagcaatgg aattattgaa 1402261 aacgcaaaag aaggtgcata tcttattgat atgacgacat ctaagccttc gcttgcgaag 1402321 aagattgctg aagcggccaa agaaaaagca ttgttcgctt tagacgctcc tgtttccggt 1402381 ggagacatcg gtgcacaaaa cggaacactc gcgattatgg tcggtggaga aaaagaagct 1402441 tttgaagcct gcatgccgat tttctcttta atgggagaga atattcagta tcaaggaccg 1402501 gctggaagcg gacagcatac caagatgtgc aatcagattg caattgcagc cggtatgatc 1402561 ggtgttgctg aagcgatggc ttatgcccaa aaatcaggcc tagagccgga aaatgttctg 1402621 aaaagcatca caacgggcgc agccggaagc tggtcattgt caaatcttgc tccccgtatg 1402681 ctgcaaggca actttgaacc gggattttat gtgaagcatt ttattaagga tatgggaatt 1402741 gcactagagg aagcagaatt aatgggggaa gaaatgccag gcttgtcgct cgcaaaatct 1402801 ttatatgaca agctagctgc tcaaggtgaa gaaaacagcg gaacacagag tatatataag 1402861 ctttgggtga aataaaaaaa gattgcctgt acgaaacagg caatcttttt ttattatttt 1402921 ccgatgaatt gttgtgtcca gatgcttcca gactcaacgt aaccaacacc gatgtgagta 1402981 aagttagggt ttagaatgtt ttttctgtgt ccttcactgt tcatccaagc ttttactact 1403041 tcttctggtg tcttttggcc cttcgcaatg ttttcacctg ctgttttgta gctgattccg 1403101 aaagatttca tcatatcaaa cggtgagccg tatgttgggc tttggtgatc aaagtagttt 1403161 ttgtctttca tatcctgaga ttttgcgcgt gcagatttgc ttaacgtttc atcaatttga 1403221 agcggtttta agccttgttt ttgtctttct gcatttgtaa gttcaacaac ttttttctca 1403281 tatgcactta cagatgaagg tgcagacgtt gttgtgtttg ttttttcagc agttgcgggt 1403341 gctttagaag cagtgttttg atcagcagct gctttttcag tagtcttttg tgcaggtttt 1403401 gccgtttctg tcttttgaac atcctgaact ttcacgttag attgcttcgc atgtttttga 1403461 agaagctgct tcatctcttt ttcgtttgca gcgtttaacg ttttgatatt tgtgttaata 1403521 tgcagttttt tcactgcatc gttaagtgac atgttttgta ctgtgttccc cgtttttact 1403581 gtaaccacag gctggcagga gagttctttc gctgatgctt gctgtacgcc cccgaatgtg 1403641 aataatccaa ccgcagcggc agcagataaa ataaatgctt tcttcattag ttcgtaacct 1403701 cctagagttg tttgtttcta cagaaaaatc ataacatagc ttttttgtca taaagattcc 1403761 agcactttcc tttgacaaat agagattgtc attttcgtaa agtaaatccg ttgaatcact 1403821 aagaataagg gaatcagcgg tatatatgat tttatcgtac cgttacatag cttccttttt 1403881 tttgaaccgt tagttatatt ttaatgtgtt tttatattga cagctttttt tactcctttt 1403941 cgctgtaaca actattacaa aggtgttaca attaatctca gtatatgtaa atatattgaa 1404001 tgatttgaga ggggtaacca gaagtgactg aaataggacg tgaaccaaag aaaaagagca 1404061 aaggaaacag agcaatcaga atgaaccttt ttttcctagc tgtctttgtt ctattcactg 1404121 cattaatttt taagctcggg gttgttcaaa ttgttgaagg cgaacagcat gaagaagacg 1404181 ctgagaaatc aaatgcaaaa acagcttact atcctgcgcc tcgcgggaag atgtacgaca 1404241 gaaaccagaa agttgctgtc gacaaccaga gcgttccaga aattgtgtat gtatcaacat 1404301 ctagcacaaa aacagaagat aaaatcaaaa cagcgaagcg gcttgcttct ttcattcata 1404361 ttgataccga atttttgaag gaaagggatc ttcgtgatta ctggatcgca gctcatccga 1404421 aaaaagccgc cgctctgctt aaggaatcag aaagcaatct gaaaggagac caggcttaca 1404481 agcttcaaat agagcgtgtt ccggatcaag aattaaaggc tattcagcaa gatgacgaag 1404541 aaatggaaac tgctgcgata tatacaaggt tttcaagcgg aaatgcttac gaacctcaaa 1404601 tcgtaaaggc aatgaatcca aataagagca atagcaatgg aaaaaacgga gcgctgcttg 1404661 atgagaagaa aaactcctcg caaagaccaa aaaatgactt aacatatgat gaaatttcca 1404721 ttgtttctga gcatttagaa gaacttccgg gaatcgatat cgtaaacgat tggacacgaa 1404781 aatatcctta tgacaaaacc ctttattctg ttttcggggg cgtcacgaca cctgatcagg 1404841 gcctgctgag cgaccggaaa gatttctact taacaagagg ctatgcgaat aatgacaggg 1404901 tgggaaaaag ttatttagag tatcaatatg aagaatattt aaattcgcat aaagaaaaag 1404961 tggaatacgt agaagataat aaaggaaatg tcgtcagcca aaaaaccatt gataagggca 1405021 gcaggggata cgatcttcag ctttcttttg acatggagct tcaggcaaag gtagaaaaga 1405081 tcattgaaga agaagtaaga aacagccgtg cacgcggaaa ttacatgctt gacagagcct 1405141 ttgccgtaat gatggacccg aataacggcg atattttatc aatggcaggg aaaaagatag 1405201 atttaaaaac caacaaaatt gaagattatg cgataggggc atttaccacc caatatgaaa 1405261 tgggatcagc agtaaagggg gccaccgtgc tagccggcta tcaggacggg atcccgcatt 1405321 ataaatatta tatcgatgct ccaatgcttt taggaacgaa tcttataaaa aaatcttata 1405381 ctaatatggg aaccatcaat gaattaaccg cattgcaaaa aagttcaaac gtatatatgt 1405441 tcaatgttgc catgcatatt gcaggcgtaa catacaagcc gcatggatct ctcccggctg 1405501 atcagaacga tctactgaaa atgagaaact attacagcca gtttggtctg ggagtaaaga 1405561 caggtattga tctcccgcag gaatcagccg gaatgcaaac cacacctaaa actgtaggag 1405621 gattaatttt agacttagca attggccaat acgatacata cacaccgctt caaatggctc 1405681 aatacatctc agtaatcgcc aatggtggct atcgtgttca gcctagaatc gtcacaagta 1405741 ttcataagcc aggaaaaaaa gaccagctgg gtaaggcgat tgaacatagg aaacctaaag 1405801 tactcaataa gattaataat tcagagagcg atttgaaaca agtacaaaca ggcatgaaat 1405861 tagtcacttc ttcagggaca gcaaaaaata cgtttacaga agatgtatca gggaaaacgg 1405921 gaacagcgga aacattttac tacggcacga atcgcaactg gtgggggaaa aaaacataca 1405981 atctgacttt tgtcggctat tacccgtcga aaaaaccaaa agtggccttt agtgttgttg 1406041 ttccatcagt agatgatgat gataagatca ataaaattat tgccaaaaga gctatccacg 1406101 cctacgcaga gctcgaaaaa aaacacagta aaaaataaaa aacagggtgc acaactaaaa 1406161 gattgtgtgc cctttctttt attcaaaaat tgacgttcac cataagaata gaaggagaat 1406221 actcattttc tagcgaatca tactaggtaa aagtcaatct gtatatgtcg aaacacgatg 1406281 atcatgcaaa ggagggattc tgtggaacag gatacgcagc atgttaaacc acttcaaaca 1406341 aaaaccgata ttcatgcagt cttggcctct aatggacgca tcatttatat atctgccaac 1406401 tccaaactgc atttgggcta tctccaagga gagatgatcg gatcattcct caaaacgttt 1406461 ctgcatgagg aagaccaatt tttggttgaa agctattttt ataatgaaca tcatctgatg 1406521 ccgtgcacct ttcgttttat taaaaaagat catacgattg tgtgggtgga ggctgcggta 1406581 gaaattgtta cgacaagagc tgagcggaca gaacgggaaa tcattttgaa aatgaaggtt 1406641 cttgaagaag aaacaggcca tcaatcccta aactgcgaaa aacatgaaat cgaacctgca 1406701 agcccggaat cgactacata tataacggat gattatgaac ggttggttga aaatctcccg 1406761 agtccgctat gcatcagtgt caaaggcaag atcgtctatg taaacagcgc gatgctttca 1406821 atgctgggag ccaaaagcaa ggatgctatt attggtaaat cgtcctatga atttattgaa 1406881 gaagaatatc atgatatcgt gaaaaacagg attatacgaa tgcaaaaagg aatggaagtc 1406941 ggaatgattg aacagacgtg gaaaaggctt gatggcacac ctgttcattt agaagtgaaa 1407001 gcatccccga ccgtctacaa aaaccagcag gctgagctgc tgctgctgat cgatatctct 1407061 tcaaggaaaa aattccaaac catcctgcaa aaaagccgtg aacgatatca gctgctgatt 1407121 caaaattcca ttgataccat tgcggtgatt cacaatggaa aatgggtatt tatgaatgaa 1407181 tcgggaattt ccctgtttga agcggctaca tatgaggatt taattggcaa aaacatatac 1407241 gatcagctgc atccttgcga tcacgaggat gtaaaagaga gaatccaaaa cattgccgag 1407301 caaaaaacag aatctgaaat tgtcaagcaa tcctggttca cctttcagaa cagggtcatc 1407361 tatacggaga tggtctgcat tccgacgacc ttttttggtg aagcggccgt ccaggtcatt 1407421 cttcgggaca tctcagagag aaaacaaaca gaagaattga tgctgaaatc ggaaaaatta 1407481 tcaatcgcag ggcagctcgc ggcgggaatc gcccatgaga tccgcaaccc tcttacagcg 1407541 atcaaaggat ttttacagct gatgaaaccg acaatggaag gcaacgaaca ttactttgat 1407601 attgtgtttt ctgaactcag ccgtatcgaa ttaatactca gtgaactgct catgctggcg 1407661 aaacctcagc aaaatgctgt caaagaatat ttgaacttga aaaaattaat tggtgaggtt 1407721 tcagccctgt tagaaacgca ggcgaattta aatggcattt ttatcagaac aagttatgaa 1407781 aaagacagca tttatataaa cggggatcaa aaccaattaa agcaggtatt cattaattta 1407841 atcaaaaatg cagttgaatc aatgcctgat gggggaacag tagacattat cataaccgaa 1407901 gatgagcatt ctgttcatgt tactgtcaaa gacgaagggg aaggtatacc tgaaaaggta 1407961 ctaaaccgga ttggagagcc atttttaaca acaaaagaaa aaggtacggg gcttggatta 1408021 atggtgacat ttaatatcat tgaaaaccat cagggagtta tacatgtgga cagccatcct 1408081 gaaaaaggca cagcgtttaa aatttcattt ccaaaaaaat aaaaacaacg gcttaaacgc 1408141 cgttgtttat cgtctgcatt gcttcacgtt tttttaatac aaataattct aaacggtcta 1408201 ggccttctct cagcgtgtcc attgagcatg caaaagacag ccttacatat ccttcaccat 1408261 atgttgagaa cgagctgccc ggcacgagtg ccacgccagc gtcttccaaa agagccatac 1408321 taaaatcaaa tgaagtcatt ccaaatgatt taatagaagg gaagatataa aacgcaccgg 1408381 acggtttaac tacgtcaagt cccatggaaa caagacggtc ataaacatag tccagacgtt 1408441 ttttgtattg ttctctcata atcaatgcat cgtcaaagcc gtttgtgaca gcttcaagcg 1408501 cggctttttg agaaatggat gaggcgcacg acacattgta ttgatgaacc tttaaaatgt 1408561 gctttgcaat gtctttcggt gcaaataaaa atccaattct ccaaccggtc atgctgtgtg 1408621 attttgacaa cccgttaatg acaatcgttt gatcccgcaa ataggttgcg atggagtaat 1408681 gcggtctgtc atatgttaat tcactgtata tttcatcaga caatacgaag acatttctgc 1408741 cttttaagag agctgcgatg cttttcagtt cttcttcaga taaagtcacg ccggtagggt 1408801 ttgacggata aggaagcacg acacacttgg tgttgggtgt cagagcatct tcaatcagcc 1408861 gggcggtaag cttaaagccg tgtgacgtag tatcaacaat gacaggcttg gccccgcaca 1408921 aattgataat aggttcatag cccggataaa taggccctgg cataatgact tcatcaccgg 1408981 gagataaaat cgtccggaat gcagcatcaa tggcttggct tgcgcctgtt gtgatgataa 1409041 tttcagattc agcatcatag ttgaaatccg cttttttctt catataaagc tgcacagctt 1409101 gtctcagctc caggtagccg gcattcggag tatatgacgt cacgttttca tcaatggctt 1409161 tttttgcggc agctttcaca tgatgcggtg tgaaaaaatc aggctggccg attgtaagtg 1409221 aaatgacgtc ttcgtgttgg gctacaagat tcgagaattt gcgtattcct gaaatttcga 1409281 tctctcttgc tttcggattc agcaaatgtt ccataattca tcaccttaac aaatataatg 1409341 agtttatcct attttaccac tagctgatca tttgtcacct ttttaactga tatatttcga 1409401 ttgtatgcgc cttttttcta aacatacctt tcttttcaga aaaaaagaag acaaccagcg 1409461 atttgattgt ctttattgta tcatgttcta ttattgttta tatgtgccaa tttcattaat 1409521 agccataatc aaaatgaagg tcttcgtgcc aaatcagata cggaggatgc tcttcttgaa 1409581 ggtcagctga ttctttcttc atattcaggt aagtttcttc actgatatcc tctaaaacag 1409641 tcatttcgtt ttctttaaat attactaagg tacccattat ttacaccctt ctttggaaaa 1409701 atccttgact attttatcac tgttagttgg aaagtcaatg gttattagga aaaaagtttc 1409761 ttttttgagg aacgcggctt gttgccttcg gaattcgatt ttgaagagct gccattcact 1409821 ttttacaaat tacgccgata tatacagtac aatactgaat gcgaatagcg agggattgaa 1409881 ttgtcgttac aacaatacga aattttattg gattctggta caaatgaatt agaaattgtg 1409941 aagtttggcg tgggtgaaaa tgctttcgga attaacgtca tgaaggtaag agaaattatt 1410001 cagcctgtcg aggtgacatc agtgcctcac tcccatcagc atgtagaagg aatgattaaa 1410061 ctcagaggag aaatcctccc tgtgatcagt ctcttctcat tttttggagt agagcctgaa 1410121 ggatcaaaag atgagaaata tatcgtgact gaatttaata aacggaaaat tgtttttcat 1410181 gtcggctctg tttctcaaat tcacagagta tcctgggaag cgattgaaaa gccgacatcg 1410241 ttaaatcaag gaatggagcg gcaccttacc ggtattatta agctcgaaga cctgatgatc 1410301 tttttgcctg actatgaaaa aattatttat gacattgaat cagattcagg tgttgacacg 1410361 tataatatgc ataccgaggg cttcgatgaa agaagaactg ataaaaagct tatcattgta 1410421 gaggactcac cgcttttgat gcgcctcttg caggatgaat taaaagaagc agggtacaac 1410481 aatatcgctt cgtttgaaaa tggaaaagag gcatatgaat acattatgaa ccttgctgaa 1410541 aacgaaactg atttatcaaa acagattgat atgatcatca ctgatattga aatgccaaaa 1410601 atggacggac acaggctcac aaagctgctg aaggaaaatc cgaaaagctc agatgtgccg 1410661 gttatgattt tctcatcgtt aattacggat gatctgcgtc accgcggcga agttgtaggc 1410721 gcagatgagc aaatcagcaa gcctgagatc agtgatttga ttaaaaaagt ggatacgtat 1410781 gttattgaat aaataaaaac agccgttgcc agaaagaggc acggctgttt ttattttaaa 1410841 agtaactctc gccaagtttt ttaaagaccg gtttatggta agctggctgc tggcgatttg 1410901 gcactagcgg cttttctttc atgccgacat attcttgcaa taggtgtttc gcttttgtta 1410961 aagacatttg agctttagga tttcgatacg attgattaag tgtacctaaa tgcggaagat 1411021 gttcgaagtc ttctttagtt ggaggcatgt gaaaatagta gtctccgatt gagataagca 1411081 cgtccgattg ctgttggctg aaccttggat tttttgaaaa atgaagccct attttctttc 1411141 ctttaccttc tttgacaagc ttttgcaaag cccgtttttt cagcagatat aggtatttag 1411201 ggttgggggc ggtttttgca tggcggttca cagtgtaaac tgcttttgaa agattttcta 1411261 cggttggctg cagatctttc gtatatgcat ggtcgtccat tatttctctc ctttgctctt 1411321 atcaatttct atatgtttag attatacttt tttaaagttg aaatgcaaat attgaatgta 1411381 aaaatgcgct tttttctaag aaaaaaagcg catttttaac ctgcattata cagatcttgc 1411441 cttctttttc ggctgttctt gaaatgcttc ctgaacattc acttccacag cctgagcact 1411501 gtattttggc agtgcaataa aataaaaaat aaaaacgagc aggataataa cacccatgcc 1411561 gtaataaaga taatcaatgt ttgaaacaaa cttagggaat aacagcgcga ctaagccgag 1411621 tgtcaaagat tgtgcaaaca tcataaaagg gtcctgcatg ccgcttacac gtcccatcag 1411681 ttttggatga acaatttttg gcatccaccc tccgattgca atgttgatcg gtccgataca 1411741 cattcccagt gcaaaagctg ccgcgtaata cacccataaa atattggtgt agccgaggac 1411801 gaagatcagc aaacctgcaa tgaaaatcgg tatcgacatt aaaaagtgcg gcttcacttt 1411861 tttagagatg agcgtgccga ttacgcttcc tgccagaagc ccaaacccga gtgcgatcgt 1411921 aaatacagac gtatgccact cataacggtc aggcgccaat ccatatttca ttgtaaacat 1411981 cggcaatacg gcgaatcctc cattgacaaa tccaaaaatg aagaagccaa aaataagaga 1412041 tgccagcaat ttgtttttta aaatatagag gatgccttct ctaaagtcat ttattgaatc 1412101 cttaacagaa gtctttctcc agctgaatgc accgtttggc tgtcgggctt cttttggaat 1412161 ccggcagctg cggatcagca gcccggaaat gataaagctg acaaaatcaa gaataatggc 1412221 gccttcaata ccgattgtgt tgtacataaa cgcgcctatg ccgactccaa acaccataaa 1412281 aatgctaaaa agcatctgat taagccctgc cgctttcgca taatgctcct tcggcagaat 1412341 ggcttgtacc aaactgtttt ctgccggaaa gaaaaacttt gttacagcgc ttctgataaa 1412401 taagatacaa aaaacaagag gaatattgcc ggtaaataaa gtgaaaaaaa gcacgacagt 1412461 caggcctgct ctgatccaat cacaattttc tgccaccttt tttctatcaa accggtccgc 1412521 gacgactccc acgatcagaa atacaaatat ggtcggaaga gaatacatca gctccgccaa 1412581 ggtcgtatat gaaggctggc tgctgaatcg gtccagcaaa aaaaaagcaa aggccatgtt 1412641 gcctactgtc gtgcccattt gagaagcgag tgctgcgaaa aatagacgaa caaaattacg 1412701 atttttaaat atatccataa aaacgctcct taccctaaag gtcccacttt atcatattat 1412761 aaaccgcctg tttttgaaac aaataagaaa acattaccgg ttaatcgtga ctctcgttcc 1412821 gtttggcaca attgaagcaa gttcgatcac gtctttgtta tgcatgcgaa tgcagccttt 1412881 agaaacagcc ttaccaatcg aagcgggatt attcgtccca tgtattccgt agtgctgctt 1412941 tgaaaggctc agccaataag cgccaaatgg gccgccggga ttgcgctggc ggttaataat 1413001 gtaaaactcg ccagtaggcg tttgcgttag tattttacca acggcgatgg gataggtttt 1413061 cattacccga ttatttaggg acagcgtaag ggtcttcgct ccgattgaga ctgcgatatg 1413121 atacggaatt gtataagggt ccggcagtcc ggggatgact atggactgtc ccgcggtgag 1413181 ccctgcctgc agtgacggat tagcctggag taatgcagcc gtgctgattc tgaaatcagc 1413241 cgcgatgctg ttcagtgtat caccttgctt cacctggtac gtaagcagtt tcctcatcct 1413301 ccttttttac ttataagtat tgatgaggag cccatcctgc tacattaatt tgtgcttttt 1413361 aaggtgaaga cagtgatttc aggcttggca agaaaccgca aaggcagcct ggtcatcccg 1413421 aggcctcggt ttacgtaaat atgagtgctg cccgtttgat acattccctc tgtgtagact 1413481 tttccatatg gaggcgtaat aatcggtccg taaaaaggca gctgaatctg gccgccgtgt 1413541 gtatggccgg aaagctgaag gttcacggga taatctgttg ttttcaaggc tgcatcaggt 1413601 tcatggacga gaagaatgga aaaaagtctg tcgctcagcc ttgaaagggt gccttcataa 1413661 tctgggtttc ccagcattaa gtcatcaagc gaagcaatct cgattttgct gccatctgcg 1413721 agtgacaatg tttgatagcc attgcgatat accgtgaaac ctccggccgt catcaggctt 1413781 ttgtaaacgg cagttccata gcctccgtga tcatgattgc cgtaaataca aagcttgccg 1413841 aagggagcat taagctttct caataatgga atgactgcct ggtggtgctg gtacgtatca 1413901 ggattatcaa taatatcacc tgtaaaaaca atgagatcag gtttagattc attaattgta 1413961 agaatgacag tttttaaatc ttcgagagta aagtaatcac tcaagtgtgc atcgctgaac 1414021 tgcacgattt taaaaccgtc aaatccgtgc gggatgagag agctttttat tgtgtgttcg 1414081 gttgtctcga tcatatgcgg ctcgagatac ctggcatagc catatccccc gccggccgtt 1414141 aaagccccgg cagcaagagc gccgaacatt ccttttagaa attgtcttct ggacatcttt 1414201 ttcatttcaa accaaccttt aatagagttt ttctattata tcatctgtat ctgataaaaa 1414261 tctcatatga gcatgtgctg acagaggcag ggatataatg atagaatatt attgaatgaa 1414321 taatcattca caattggagg gataaacatg gaaaaaaagg cggtaattat taccggcggg 1414381 tcaagcggca tgggaaaagc gatggcaaaa aaacaggctg aattagggtg gcacgttatg 1414441 gtgacaggga ggaaccatga ggcacttgag gaaacaaaaa aagaaattca gacctttgag 1414501 ggacaggtcg cttgttttca aatggatgtc cgttccgatt ccgccgcttc agacatgatt 1414561 aaagaagcgg taaaagcctt tggccggctt gacgcgctga ttaacaacgc ggccggaaac 1414621 tttatttgtc cggcagaaaa gctgacgccc aatggatgga aagccgttat tgagattgtt 1414681 ttaaacggca catttttttg cagccaagca gcggcaaggc attggattga ccagaagcag 1414741 cagggtgtca ttttaaatat ggcagccacg tacgcttggg gagcgggagc gggggtcgtt 1414801 cattccgctg cagccaaagc gggggtattg tcattgacaa gaacgctggc cgttgaatgg 1414861 gggagcaaat acggcattcg tacaaacgcg atagcccccg gaccgattga acgaacaggc 1414921 ggtgcggaga agctatttga atcggaaaaa gcgatggccc gcacgatgaa cagtgtgccg 1414981 ctcggccgat tgggcacacc ggaggaaatc gccgctttgg cagcgttttt gctttctgat 1415041 gaagcatcct atataaacgg ggattgtatc acaatggacg gggggcaatg gctgaatcct 1415101 tatccgtttt aatctgaata tttataagtg aatatttaag ttattaagaa cttttatgtt 1415161 cgaatgtaat acctccacaa ttaaccttct tcctatccaa tttgataaca catagagctt 1415221 tatttgttta tgaggtgttg tgtcatacgt aagccaccta atatatgaaa ggtatatttt 1415281 aaaaggggag acgaaatatg aagaacttag atttcaaata aaacattcat ataattactt 1415341 cgttaactaa aaagagaaat tataagaatg aaaggtttca aggttacatc agattgggag 1415401 gaaggtaata taatggacga gatggtatta ttaactcagg aatggctcaa tgaaacgtac 1415461 aaaggaaaaa gtggctacaa ttccattgag gaaaatggga aaactggctg gaaaacaatg 1415521 tatgcattaa ctagagcatt acaactagaa ttgggaatta cacagacttc cgacagtttt 1415581 ggtcctacaa ctttaagaaa gcttaaagaa ttaggcccga tttctacgtc aactaattca 1415641 aaaaaaaata ttgtgaaaat tattcaaggt gctctttatt gtaaaggtta tggtccaggt 1415701 ggattaacgg gtacatttgg tcagggaacg aaagaggcga tagcagaaat gcaattgcat 1415761 atggggcttt ctaaaacaga cggtgtagta acgcctaagg tgtttaaagc tttattaaac 1415821 atggactctt atatcctttt aaatggggcg tcagagaaag ttcgttcaat acagcaatgg 1415881 ctaaataata aatattacaa tagagagaat ttctacttta tgccctgtga tggcctgtat 1415941 tcaagggata ctcaaaagtc tcttgtttat gcaatacagt acgaggaagg gttaagtgat 1416001 agtatagcta atgggaattt tggaccaact actcaaagat tgattcctgt attaagaatt 1416061 ggagaaacag atgaaaaaaa cagttttatt catttatttc aagctgctct aatctttaat 1416121 ggctacaatg ttccttttga tggagtatac tctgaatctg taagatcaaa agtaaaggct 1416181 tttcagtctt ttgcaaaatt acaacagagt ggtactgccg actttcaaac atgggcttca 1416241 cttctagtaa gtactggaga ccccaatcga aaaggagttg cttgtgactc aattactcaa 1416301 attacatcgg acagggcgga gtcccttaag agggcaggtt ataagattgt agggcggtat 1416361 ctaacaaatg cgccggggag tacactaaat aaaaaaatac aaccaggtga attagaaact 1416421 atcttaaaat caggtttaaa tgtttttccg atttatcaaa cctatggggg agcaacaaat 1416481 tattttaata aagaacaagg aaagaaagat gcgtttgctg cttataaagc agcaaaagaa 1416541 tacgggttta aaaataacac tgtaatatac tttgcagtag attatgatgc atatggtaac 1416601 gatttaaaca acaatattat tccacacttc gaaggtataa atgaaataat gaacggtttt 1416661 ttaggttcaa cttacaaaat tggtatttat gcccctagga atgtatgtac tatagtttct 1416721 aaaaaaggtt tagcatttgc aagttttgta agtggtatgt ctactggctt tagcggaaac 1416781 ttaggatatc ctttgcctta caattgggcg tttgaccaaa tttcaacaat tactgttgga 1416841 aatggttctg gaatgattga aattgataat gatatttgtt caggtttgga taatggagtt 1416901 aataccataa atatagtgcc ttcagagaat aagaagtttt ttgatcaaat tgatgtttta 1416961 tatgaaactg ctgaaaaata tgctcaaatg caaagcgact taaataatgg ggtaaaaaaa 1417021 acacaattag ctaatgagtt ggttgcccag tatttaagaa aggatgacta caaagggtgg 1417081 aagtgggtcc ctaccgcagg ccagattgat cctatttatc gtgaatgggc agtaaagcgc 1417141 taggggaaga cctagtaaat ggaattgttg atcctatatc aaaaactgtc ataggaacgc 1417201 agcatcttat ggcaacttat aatgccatta tttatagtgg tggttactct caaacactac 1417261 gagattttgc tggttggact ggagatctat taacaacaat acaggacatg aaattacacg 1417321 ctcaagaatt taattcgcct tatgatgcgg ctatgaaaat aataggtaat atgtatcaat 1417381 ttagcctaga tgatttattt agtgatgtag atgcaattaa tctagcgaat aaaacatcag 1417441 ttggtgctaa tgcacaacct ctaaatatcg caattagaga ttattatagt aataatgact 1417501 gtatgaatag gttcactcaa tttgtaaata atagatttga tggttcgtta gacaaaattt 1417561 tctctgaagc agagtattat ttaaatacaa accttgaccc agttgttgtt ccaattaggt 1417621 tagcctttaa acgtgctttt gatgttgagg attatagtga agagattgga aaaataacag 1417681 cacaagcatt tagagatgtt atcgagaaaa aaatgatatc tgaataaact gcaaaacaag 1417741 cgaacgttaa aactggtcgt tcgcttgttt tattttctat ttaaatttat gatataattt 1417801 ttaaagatta aggagtgatt cattgaagaa attgttaaaa aagttagttg tattattttt 1417861 aagcagttta gttatcatct ttaatgtttg gtactttatt atttgtgctt tttccccaga 1417921 gtattatcaa aatacaaatc ttacttctaa tgaaataata agatttgaaa aactatacca 1417981 catagatttt cctgatgaaa caaaatttat taaagctaga gagtatttgg ctgggcccgg 1418041 aggagatacg tcagctgtat tatatgtgtc tctgccaacc aagcgggtag aaaaagtttt 1418101 atctgattac acgtatatga aaataaacta tactgacaat gtcggttcaa tgtatggagt 1418161 tgacgtttca aagagtgtcg ccggtttaac aactcttaca tttggcactt acgataaaaa 1418221 aggaactttc tataatatga aacatgatga tgattggatg tataaaggca ctgactggaa 1418281 tctttacttt tggacagctg ctagttataa tgctgttatt tttgtatttg ttttggttat 1418341 tgtgaaacaa atgaataaaa ttcttaatta accagtatgt agattgataa tctcaaaaaa 1418401 attttcctct tcttttaaca tactccatac gacctacttt tccatactat gatttttttg 1418461 aaatttgtgg tgtagttata attgtgcgta taatcagaca aagatagaga agcaggtgat 1418521 aacatgttgg atccacttga tattttaacg aacattgatg atgtccttcc atattaccag 1418581 gcgattttta gtgccgagga gcagaaggtt gtcggatatg aggtgcttgg acgaattttg 1418641 gcagattcag aaatccaaag tctcgggccc ttctttttag atgcggggat acccgaagaa 1418701 tataaattag aggttgataa cagaattatc cgccaggctc ttgaccgctt tttagaggcg 1418761 gattctgatc tgctgatttt tatgaatcag gatgccaatc tgctgatgct ggatcatggt 1418821 gaaagctttc tggagcttct gaaagaatat gaagcgaagg gaatcgaact ccaccgtttt 1418881 gtgcttgaaa ttacagagca caattttgaa ggggatattg agcagctcta ccatatgctt 1418941 gcatactatc gtacatacgg aattaaaatc gcagttgaca acatcggaaa agaaagcagc 1419001 aacttggaca gaatcgcgct gctctcacca gatctgttaa aaatcgattt gcaggcgctg 1419061 aaagtgtcac agccgtcacc gtcatatgag catgtgctgt acagcatatc tttattagca 1419121 agaaaaatcg gtgcggcgct gctgtatgaa gacattgagg cgaacttcca gcttcagtac 1419181 gcctggagaa acggaggccg ctattttcag ggctattact tagtgtctcc atctgaaacg 1419241 tttctagaga gagatgtatt gaaacaaaga cttaaaactg aatttcacca atttatcaca 1419301 catgagaaaa agaaactgga gaccgtctat gagcactctg aacagtttta caaacgagtg 1419361 catcaggctg tgacctcttt gagaaaaaac aatctgtctt ctgatgatga ctttattaaa 1419421 aagctggcgg aagagctgac agattgcagc ttcaggattt acatgtgtga tgaagaaggc 1419481 gatcagctga cgggaaatgt gtttaagcaa gatggagaat ggatttatca gccggaatat 1419541 gcggaaaaga actggagctg gcgcccttat tttctggaga acattatgag aatgagaaat 1419601 ctcagaaaag gttttttcag tgatctgtac agtgatttgg aaacaggtga aatgatcaga 1419661 acgttttcat atccgatgga tgatcagatg tatttattta tagacttgcc ttattcttat 1419721 ttatatgagc aggacggact gatttaacgg ctgaaaggcc gtttttttta tgaaatgaaa 1419781 aaaatatcaa aaaacgattg acattgatac tgagaatcat tatcatttaa ttatagagag 1419841 aagctactct ctgttcccca acccctctat cagatcaaga tccgaaaaaa cttggcgcta 1419901 cccccgccaa gttttttatt tgtcaaagca taggacaatc caatgaaaca ataaacctaa 1419961 ctagtggtaa acgtttaaca cggggagaaa cattgagtgc cgaacacccc tgacactgct 1420021 gcacgggtga ggaggaaaat tcgttctgaa atgattattt cagttccgtt gtttacctct 1420081 atccagcatg actcccattg attatggcca cgcgggactt caccataaaa ttcaaaagaa 1420141 ggttttgaca aagttgcaaa aaggcattct taatgctgcc aaagattcga aaaaaattat 1420201 aattatgtgc atgacattca aaaaaagcct caaactaaag aaaaatagtt tttttcactt 1420261 tttttctttg cttaaattca gcagtgaaaa tgccatcctg tccgacttta tggtatgatg 1420321 ctcaatagaa cttgtattat aataaatact tgttgatttg aagttgcttt ttgaaaggag 1420381 tcttttttta gaatgtcaca attaatgggt atcatcacac ggctgcaaag tctgcaagaa 1420441 acagcggaag cggctaacga gccaatgcag cgttatttcg aagtgaatgg tgagaaaata 1420501 tgcagtgtta aatatttcga aaaaaatcaa acgtttgaac tgacggtttt ccaaaagggt 1420561 gaaaaaccta acacatatcc gtttgataat atcgacatgg tttccatcga aatctttgaa 1420621 cttcttcagt aagattcctg aaataggggg aacaagcttc cgcctttgca aaagtaatcg 1420681 aaataaacgg taaggaacat acttgtttca tggttgtaaa tccttgaaaa ggagtgtcgt 1420741 gatggctgat tcttttctgt tttataatct ttcagaagca cagatgacct ttcaagatgt 1420801 gatggaacgg cttaaagcct ttgttcaaaa ggacccccgt tcttcttatg tgttatcgat 1420861 cggaaccgat tcacaggttt accgcgatta cacaaagttt attaccgcat tgcatttgca 1420921 tcgtacaggc aagggagctt ggggctgctt gaaaaatcat acagtcgaca gacccataca 1420981 tagccttcgg gagaagattt cgttagaaac ggcgtacagc caagaaacgg ccgctcatat 1421041 tcttgatgga cacttaatgg atattaccga tctgctcctg ccctttaccg gtgagggggc 1421101 ggatcttacc tttgaagttc acttggatat tgggaaaaaa gggcttacaa aagatctgat 1421161 ccaagaaatg actggacgta ttacctccat ggggattgag gccaaaataa agccggattc 1421221 atacactgcc ttcagctatg caaatcgttt cacaaaataa tttggctgaa aaagccaagg 1421281 taaatgtcga attatgcggt tgacgtttgt tatctgatta cttattctag cggtagagct 1421341 gaaagtaagt tgtcttgctt tcagaggtat tcagtataaa acagggggcc tgattgcgaa 1421401 tgagtcttat cggtgaacga tttacagaag aagaacaaaa acttctgctg aatatcctga 1421461 tcaaccatga gtatgccatc gagctattaa gcagtgagat caacgatata gagacaggga 1421521 ccaaaaacgt tgacggaacc acctacaaaa aacttgtaac gctatacgac cgatttcgat 1421581 ttgaaaatta atgggacacc ctataattga tactccacaa agagtatctt ttttattgaa 1421641 aggaaacttt tcgacaaata ctgataaagt ttatattatt gcaatatagg gaatgtattg 1421701 atgatgaaaa tgaaaagggg tcgaaaacat gataagctta caatcagatc aacttcttga 1421761 ggcaacagtc ggacaattta tgattgaggc ggacaaagta gcgcacgtgc aagtcggaaa 1421821 taaccttgag catgcattat tagtattgac aaaaaccgga tacacagcca tcccggttct 1421881 ggatccttcc taccgtttac atggcttaat cgggacaaat atgatcatga acagtatttt 1421941 tggacttgag cgaattgagt ttgaaaagct tgaccaaatc actgttgagg aagtcatgct 1422001 gaccgacatt ccgcgccttc atatcaatga tccgattatg aagggattcg gcatggtcat 1422061 taataacgga tttgtctgtg ttgaaaatga cgagcaggta tttgaaggga tttttacgag 1422121 aagagtcgtt ttaaaggaat tgaataagca tatacgctca ttgaataagt aggctgtacg 1422181 gtcctatttt tattatatag gcagagtgaa aaaagaaagc gcatacataa tttaaacgag 1422241 aatagggctt gaataagaaa ctaagatttt attagaatgg gagataagaa aaacttattg 1422301 ataacaaaaa ggaggacgac atgcagcttc aagagcttca tatgctcgta gttttagctg 1422361 aggaattaaa tatgagaaag gcggcagaac ggctttttgt atctcagccg gctttatctc 1422421 agcgcttaca aaccattgaa aaggcgtggg gaacaaaaat ctttttaaga tctcaaaaag 1422481 gattaacggt aacgcccgcc ggtgagaaaa tcattcagtt tgcgaatgat gtgacattag 1422541 agcaggaaag aataagagaa aatattgacg agcttgaagg tgaaattcac ggcacattga 1422601 agcttgccgt cgcctccata atcggtcagc attggctccc taaagtcctg aagacgtatg 1422661 tggaaaagta tccgaatgca aagatctcgc tcataaccgg gtggagcagc gaaatgctga 1422721 aaagcttgta tgaggatcag gttcatatcg gcattataag aggcaaccct gagtggaagg 1422781 ggcgcaaaga ttacttaatg acagatcatc tgtatttagt ggatactgaa atttcctgca 1422841 tcgaagatat tgcccataca gaacgtccgt ttatccagtt taaaagtgac agcacttatt 1422901 ttcaggaaat tcagcactgg tggcatcaaa aatttaaaac gtcgccgaaa cagacgatat 1422961 tggttgatca gattgaaacg tgcaaacaga tggcgctgca cggaatcggt tatgccattt 1423021 tgccgtctgt tacccttcaa aatgaagata aagtgaataa aatgcctctt ttagacatga 1423081 aagggcatcc gatcggtcgg gatacatggt tattaggtta tgagcctgcc tttgaactga 1423141 aacaagttca agcttttgta caagtgataa aggatatgct ggatcaggaa aatccatttt 1423201 aaagacagcg aggtgctgtc ttttttttat ttatctgttg acaatgaaaa tcattatcat 1423261 ttaaagtgat acatatgata ttgaaaatca ttatcaacta atggggtgat aacatggcta 1423321 aagccttgat tacatatgcc agcatgtcag gaaatacaga agacattgcc ttcataataa 1423381 aagatacgct tcaggaatat gagttggata tcgattgtgt cgagataaat gatatggatg 1423441 cgtcttgttt aacctcctat gattatgtac tgattggcac ctatacatgg ggggacggcg 1423501 atttgcccta cgaagcggag gattttttcg aagaggtcaa acagattcag cttaatggtt 1423561 taaaaacagc ctgcttcggg tctggcgatt attcttatcc aaagttttgc gaagcggtga 1423621 atttgttcaa tgtcatgctg caagaggcgg gagctgctgt ttaccaggaa acactaaaaa 1423681 ttgaattagc gcctgaaaca gatgaagatg tggaaagctg ccgagcgttt gcgagaggtt 1423741 ttcttgcatg ggcagattat atgaacaagg aaaaaatcca tgtttcataa aggggcaacc 1423801 gctgttacgg catcggcgtt ttctggatat tttgtggcgg tacaaagaga aggcattttt 1423861 cattactctt tggagcaggg ctggagaaag ctttttcgtt tgaaaagtaa gatacactgt 1423921 atcagctaca tagggcctta cttatttggc gttggtgaaa agggaacagt cattcgttcg 1423981 gctgatgaag ggaaaacctg gacgatgtcg agctttccga caaatgcaac agtgtgggcg 1424041 attaccggca gaaacaacgg gtttgtctgc gcccacggta agcattgtat ttatgtatcg 1424101 gatgattttg gtgtctcatg gcgcgtagcc aaaccttttg ccgaatttca taatccccct 1424161 gttatccggt cgttatgcct tcacgggggc aatctcttta tcggcacgca aatacacgaa 1424221 tattttggcg gcatttgggc ttacgacatt aagcgtgaca ctgtccaagt tgtcaaaaaa 1424281 gaaaaaaacc ggatgacggc atccatgctc gtgttcaatg aaaattggct ggtggcggcg 1424341 atgggttctg tgaaaggaaa gcacggtgct gtcactgtaa ggaatctttt gaatggtgaa 1424401 gaattcacca tacaatccag tatgatcaga aatgaagaat catttcttga tctttcagag 1424461 gatgatggca ttatatatgt cactacaaca caagatgaaa atggtttttc gagaatttac 1424521 caggttgatc tcgaagcccg gtcgttaaaa tggttcgata ccattaaggg acatggatgg 1424581 agagtggcca atcagaaaga gaatttcttt tgcgcaggct tgtatgaatg taaatttgtc 1424641 cagccgtacg aagtttcagc aatgattcat tagaggagga acaaggaatt ggcgaagatt 1424701 ttgctcgttt atgcaacaat gtcaggcaac actgaagcta tggcagattt gattgaaaag 1424761 gggcttcagg aggcgttagc agaagtagac cgtttcgaag caatggatat tgatgatgcc 1424821 cagctgttta ccgattatga ccatgtcata atgggaacct acacgtgggg agacggagat 1424881 ctgcctgatg aatttttaga tcttgttgaa gacatggagg agattgattt ttccggcaaa 1424941 acatgcgctg tattcggttc cggtgataca gcatatgaat ttttctgcgg agcggttgat 1425001 acgctagagg caaaaataaa agaacgcggt ggagacattg tgctgccttc ggtaaaaatc 1425061 gaaaataatc cagaaggtga agaagaggaa gaattaataa acttcgggag acaattcgca 1425121 aagaaaagcg ggtgcgctgt ctgatcactc actgggaact gctaaaacgg ctgttccttt 1425181 ttttcttgtc tttgtatctt tcctttgata cagtaatgag gtagaaaatc aggaggagga 1425241 ctatacatat gaaaatgatg gacgcaaatg aaattatttc atttattcaa aatagtacaa 1425301 aatctacacc tgtaaaggtt tacgtgaaag gtgagctgga aggaatcaat ttcggtgaat 1425361 ctgcgaaagc ttttatcaat ggaaacactg gtgtcgtttt cggtgaatgg agcgaaatcc 1425421 aaacagcaat cgaagaaaac caaagcaaaa tcgaagacta tgtggttgaa aatgaccgcc 1425481 gcaattctgc gatcccaatg cttgatctta aaaacatcaa agcgcgtatc gagccgggtg 1425541 cgatcatccg cgaccaagtt gaaatcggtg ataacgcagt catcatgatg ggtgcttcta 1425601 ttaatatcgg ttcagtcatc ggcgaaggca caatgattga tatgaacgtt gtgcttggcg 1425661 gacgagctac tgttggaaaa aactgccata tcggcgcggg ttctgtactt gcgggcgtta 1425721 ttgagccgcc atccgctaaa ccggttgtga ttgaagacga cgtcgtaatc ggcgcaaatg 1425781 ctgttgtgct tgaaggtgta acagtaggta aaggagctgt tgttgctgcg ggagcgatcg 1425841 tggtaaacga cgttgagcca tacactgtcg ttgcaggcac accagctaaa aaaatcaaag 1425901 acattgatga aaaaacaaaa ggcaaaactg aaatcaagca ggaattacgc cagctgtaag 1425961 gaaaagtttg ataaaaaagg cgtggataat atatccacgc cttattcgta taggcaggag 1426021 gaatagaaat gaagatagag gagctcatcg caattcgcag agatctgcat cgtataccgg 1426081 agcttggatt tcaggagttc aaaacccagc agtatttatt aaatgtcttg gaacaatatc 1426141 cgcaagacag aattgaaatt gagaaatggc gaacagggct ttttgtaaaa gtgaacggga 1426201 cggcgccgga aaaaatgctg gcatacagag cggatatcga tgcgctttct atagaagagc 1426261 aaactggtct tccattcgca tcagagcatc acggcaacat gcacgcctgc ggtcacgatt 1426321 tgcatatgac aattgcactc ggcattattg atcattttgt tcaccaccca gtcaaacatg 1426381 atttgctttt tctgtttcag ccggcagagg aagggcctgg cggtgcggaa ccaatgcttg 1426441 agagcgatgt attaaaaaaa tggcagcctg atttcatcac tgcccttcat attgctccag 1426501 agcttccggt aggcaccatt gcgacaaaaa gcggccttct atttgcgaat acatcagagc 1426561 tagtcatcga tctggaaggc aaagggggac atgcggcata tccgcatttg gctgaggata 1426621 tggttgtagc agcaagtaca cttgtcaccc agctgcaaac gattatctct agaaacacag 1426681 atccgctaga cagtgctgtt attacagttg gtaccattac cggaggctcg gcacaaaata 1426741 tcattgcaga aacggcccac ctggaaggca cgatccgcac gctttctgaa gaatcgatga 1426801 aacaagtaaa ggaacggatt gaagatgtag tgaaaggaat cgaaatcgga ttccgctgca 1426861 aaggaaaagt gacatatccg tctgtatatc accaagttta caatacgagc ggattaacag 1426921 aagaatttat gtcttttgtt gctgaacatc aactggcgac agtaattgaa gcaaaagaag 1426981 caatgactgg agaggatttt ggctatatgc tgaaaaaata tcccggattc atgttctggc 1427041 tcggcgctga ttctgaacat gggcttcatc atgctaagct gaatcccgat gaaaatgcga 1427101 tagaaacagc ggttcatgtc atgacaggtt atttttctgt ttatgccaat taagtacaaa 1427161 tgaaagaata aaattccata aaatgagcac tctagtaaac ggaggtgttc aaaaatggct 1427221 aaaaaaattg gaattgaaca atcgttatca gatgtagaag ctgctttaaa agaaaaagga 1427281 tatgacgttg taatgatgaa aagccctgct gatgctcaag gctgtgactg ctgtgtcgta 1427341 acaggtcttg ataataatgt gcaagggata gccgatacgg taacacaagc acctgtcatt 1427401 acagcttccg ggatgacggc tgaagaaatt tgtagcgaag ttgagagcag aattcagtaa 1427461 taaaaaaacc gaagcaaaaa gcttcggttc ttttatttat tctgtttctt tagggaaagc 1427521 gcggtcgaac gcgttcttta tttcttttct caacactcgt tcgactcgcc actgttccat 1427581 attttctgtt ttggcaatga ccctgattac aatttcagaa gtccccagtt cttgaatccc 1427641 gatgacattt gggccttctt ttatttgtgg aagagccgct gccgtttcat cacaaacctg 1427701 ctgtaaaata tgaatcattt catcaatatt tctttcagcc ggcactttaa tgtcaacaag 1427761 agcctgcatg gtaccacgag aatgattgct cacgtttgtg atgtttctgt tggggatgta 1427821 atgcagtgtt ccgtcaaagc tgcggatttg agttgtcctt aagccaacct gctcgacaat 1427881 tccgtcaaag gtggaaacgg taatataatc tccgacatcc aattgtttct caagcaaaat 1427941 aaaaaaacct gtcacgatat cactgacaag cccttgggcg ccaaatccga cagccaggcc 1428001 gacgattcct gcccccgcta aaagagcgct tggatcataa tgaaacaaat ctagaaccat 1428061 gacgaaaaat atgaaaatca atgtataagc aaatatgtta agagtcaggc ttcggagcgt 1428121 atgtgcacgt ccgatagaca agctattctg ctcctcgaat tttgcaaaca gatgtttaat 1428181 gattttcatg cctaatgatc gaacgataaa atagagcaat atcataatgg cgagtttaat 1428241 gagcagaaca ccggcatttg taatcagtcc cgcccaatca tattgtttaa taaagtccat 1428301 gttgagctcc ttttctaatt gattgctgca cattgagact agttaccctg tacatgacca 1428361 tgttaaacgt tttattcaaa aatgtcgaag ccaaagacat acatgatttg ttaaaaattg 1428421 actcaggaaa tctgctttta tataatggca ttgcaatata actaaaaatg gttaatcacc 1428481 ctttattttc atgcgatttt gacctttaag ccaaacaata aattggaggg atacatatgg 1428541 cagaacgtat ggtaggtaaa caagctcctc gttttgaaat ggaagcagtc cttgcaagca 1428601 aagaattcgg caaagtaagt cttgaggaaa acatgaaaaa cgacaaatgg acagtgctgt 1428661 tcttctatcc aatggacttc acttttgttt gtccgacaga aattacagca atgtctgacc 1428721 gctatgacga gttcgaagat cttgatgcag aagtcatcgg ggtttcaact gataccatcc 1428781 atactcattt agcttggatc aatacagacc gcaaagaaaa cggtcttggc cagctgaaat 1428841 acccgcttgc tgctgataca aaccatgagg tatcccggga atatggcgtt ttaatcgaag 1428901 aagaaggtgt ggctttgcgc ggattgttta ttattaatcc tgaaggggag cttcaatatc 1428961 aaactgtttt ccataacaac attgggcgtg atgttgatga aacgcttcgt gttctccagg 1429021 cgctgcaaac tggcggactc tgtccggcta actggaaacc aggccaaaaa acactttaat 1429081 tctttccaag aacgaaaagc ggtctagcat attcgttagg cctctctttt aaaataggag 1429141 ggaaaaagca atgaaattac gtcagcccat gccggaattg acgggagaaa aagcttggtt 1429201 aaatggtgaa gtgacgagag agcaattgat tggggaaaag ccgacgctta ttcatttctg 1429261 gtccatcagc tgccacttgt gcaaagaagc gatgccgcaa gtgaatgaat ttcgtgataa 1429321 atatcaagat cagctgaatg ttgtagctgt acacatgccc cgttccgaag atgatcttga 1429381 ccctggtaaa attaaagaaa cagctgctga acacgatatc actcagccga tttttgttga 1429441 cagtgaccat gctttaaccg atgcatttga aaatgaatat gtacctgcat attatgtgtt 1429501 tgataaaaca ggacagctcc gtcacttcca agccggcggg agcggtatga aaatgcttga 1429561 aaaacgtgtg aaccgcgttc tggctgaaac ggaataggta tctgactaaa tagtatttcc 1429621 taaaaacctg acctcatcag gttttttatt tgtgcaaaaa gcaatggaag aagagtaaga 1429681 agcttatttt tccaaatttg ggtataggaa ttgatgattt gtttgattga tacgctaaaa 1429741 aacacagcta atttttgatg tttttcctca attttagata aatctcatat ctcataactc 1429801 gaaaattgta gatattacac taaatttctt taaagaagta agtaaaatat atattttcaa 1429861 cattatacca aataaactag aaagcccctt aatcccttga gaataaagga ctcttttgaa 1429921 aaataaaaca ttttcagaaa ataaggaatt tttcatagag taaatataat agtaaaatgc 1429981 taaaataata gttgataaaa ttacttttgt aatctaatat cttaattaaa gatgttaatt 1430041 ttgatagggg gtacattgag gaatgtttaa tgaaagagaa gctttgcgct tgcggttaga 1430101 acaattaaat gaagctgaag tgaaagtcat tcgtgaatat caaattgaac gtgataaaat 1430161 atacgcaaaa ttaagagagc tggacagaaa tggaagccct tccgaaatca aaaaggattt 1430221 ccgttctgaa aaaaaacctg actctctgcc ggttctcgct gagcttgcgg ctcaggaaat 1430281 cagaagctat cagccgcaat cacagcagca gtctgttcag cctcagcttc aatctatttc 1430341 ctctcttcct gccggtatac cagacggaac aacacgaaga agaagaggaa cggcaagacc 1430401 gggatcaaaa gcagctaagc tgcgtgaagc tgctattaaa acattaaaac gccacaacgc 1430461 ggcgattaag agctcggagc ttcaaaaaga gattgaaaaa gaaagcggtc ttgaaatccc 1430521 taatatgaca acgtttatgc aaagcttaat taaaatgtac ccggaagtga aaaagccata 1430581 tcgcgggcag tacattttag agggtgaaat cgaatctgca gaatcagcaa acgaataaat 1430641 ataaagaaaa actgcttggc atcgctcaag cagttttttt attgaggttt tttctgtgaa 1430701 ggtttgtttt ctttttcaag attaagctta tacacccact tttgataagg cttttcttca 1430761 gcggctctgt ttttcagctc ttcgattgta tggctcttgg cctggtctga tgattgggcg 1430821 tgggcaagct gtttttgaag cacatgtatc tgtttggtga catcttcaag gatagtctct 1430881 acatgatttg gctgcgcgta ggccgctgga gcttcttctt ccgttttttc tttttgtttc 1430941 gtgccgccat caatatcggc aaaatgagaa gcaatccagg catcgctttc atcaagttgc 1431001 cgtttatacg atataatagt ttcgtgaaat aatttttctt tcgttttttc tatgtctagc 1431061 agtctttctt tcgtttctat gattcgatct ttcatatgat caacttctat tttaatatgt 1431121 tttagctgat attctttttc taccatttgc tcttttagac gcccgttttc ggcttttatc 1431181 aattcggctt gctgttttgc ctgaagcagt gcattttgtt cctgctcaat tgaggcttga 1431241 agttcgctga tccgtttatg aagattttta ttttcttctt cgattttgac tttcgcaata 1431301 tgaagtttat gtttttcttc gatttcggct ctgcgtttat aggtttcagc agatagaagc 1431361 tcctgcaaaa caacgatttt atcaagcagt tcagctctta tttggtgcag ggtttggctg 1431421 gtgtgggagg catgtttttc ttttgttgac atatgtgtta attcggcaga cagctgctgg 1431481 agtttttctt tcatatcggt attttctttg agcagtttgt tatttttctg atgaaagtag 1431541 cttgcttcaa gttcagaaat cagcttatgg caccttgaaa gctcggattt taaataaagg 1431601 ttctcctgag acacgtcgtg gaaaaaagga cctgatcttt tcattcgaac catctccctc 1431661 atgatgttaa cactacaata tgcaaatact gaacagctat tcctctttaa taaacagaca 1431721 agcagtagcg ttgagccttt gcttttgcta tgcttttaac gaaactagag gtgagatgat 1431781 atgaagcatg taaacgtact gctggcaggg ggagcctcac gtcgctttgg agaaccgaag 1431841 gcgtttgtca aatggaaggg caggatgctt tacgaatgcg ctaaagaggc acttggagaa 1431901 caaacggtta tcatcagccg tcccgaattt attgatagat ttcaagaaaa cggtgaaaat 1431961 gaagtgtatc aagatgctga gccatttcaa ggcatggggc cattggctgg tatatatacc 1432021 gcttttaaaa agacagacgg tgatctttat actgttcttt cctgtgacac accgctgata 1432081 caaagaagga cgatgctgga gctcaaacgt ctgatgattg ccggtgcgga cgcggtagtc 1432141 ccaatttcag acggacaagt gcagccattg attgcgattt accacaaacg tatcatgcca 1432201 gttctatacg atcagctttc tgagaagagg ttgagaatat cagatttatt aggcagaatt 1432261 tcggtttgtt acgtacaggc tgaaaatatc ggagcaaacc cggcagagtt tatcaacatt 1432321 aatacacgtg atgattttag ctgtttggaa gaaaaatcga actccctcaa gcgggactga 1432381 cggggcaata acatgataag atgacataaa agataaggag aacaggtttg atggaggaac 1432441 gttattcacg gcaaatcaga tttaagcaaa ttggggaaga gggccagaaa agactggcag 1432501 acagccatgt gctgattgtc ggagcgggag cgctcggcac tgcaggagct gaagggcttt 1432561 cgagagcggg agtcggtacg attaccatta ttgaccgtga ctatgtggag tggagcaatc 1432621 ttcaaaggca gcagctttat acagaaagcg atgccaaact ccgcatgccg aaagccatgg 1432681 ctgccaaaga gcatctatca gcgattaaca gcgagataca tattgaggcg tatgttaccg 1432741 aaggaacagc cgaaacgctt gagccgctga ttgaaaaagc agatgtcgtg atcgacgcga 1432801 cagataattt tgaaacccgc atgctgataa acgatcttgc ccagaaaaca aagacacctt 1432861 gggtctatgg cgcctgtgta agcagccagg gaatgttcat gactgtcatt cccggagaaa 1432921 ccccttgtct gtcttgtttg tttgagcaaa ttcctgtcgg cggggcgacg tgtgatactg 1432981 ccggcattat tccgcctgct gtgcatatcg tttcagcata tcagcaggct gaggcattaa 1433041 agctgttaac cggccaaaaa gaagcaatac agcgggggtt tgtgacattt gatgtctgga 1433101 acaattcgca tatgaagatt aacgttaatc atgtacgccg tgaggaatgc ccatcttgcg 1433161 gagctaatgc ggtatatcct tatcttcagg attggaacac accaaaagct gctgtactat 1433221 gcggccgtga tacagtgcag gtaaggtcag aatcattaaa aagaatcccg aaacaggagc 1433281 tcattaagcg gctgaaaaca atcggcaagg tcgaggctaa tgcgtttttg ctgcatattt 1433341 tttacgagga tttcagaatt gtcattttca atgacggacg ggcactggtg catggaacaa 1433401 atgatgtgaa agaagccaac tccgtgttgg caagagtgat tggactgtaa caacaggagg 1433461 ggtcagaatg ctggagaaaa gaacaccgat accggtagac gaggcagttc ggcgtgtctg 1433521 ccattttcaa aaacaaggtg aaacagaatg ggtggcgctt gaagacagcc ttcatcggtt 1433581 tttagccgaa gatataactg cggatcacca cgtacctgcg tttgaccgtt cgccatacga 1433641 tggttttgct gtcagagcgt gcgatacggc agaagcttca cgtgaaaacc cagttcggtt 1433701 tgaagttatt gaccatattg gagcgggagc agtatctgaa aaagaacttg gcccgtttca 1433761 ggccgtgcgg attatgactg gcgcgcaaat ccctgaaggg gcagatgcag tcgtcatgat 1433821 tgaactgact caagcctttg aggagaatgg gaagtcattt atgtctttaa aacgccgctt 1433881 tcagacgggg gataatattt caaaaacagg tgaggacgct caaaaaggga gtgttttact 1433941 gacaaagggc acccgggtga caccaggagt gacggctctt ttggcaacat tcggatacgc 1434001 atctgtgcct gtcgtgagaa agcctgtagt cgggattatc gcaaccggta ccgaattgct 1434061 gaatgtcagt gatccgctgg aaccgggaaa aatccgcaac agcaatgcga gtatggtata 1434121 tgcgcaagcg atagaagcag gcgcaacacc gctttattta gggaaaatct ctgatgaact 1434181 ggataaaagc tttgctgcag ttaaagaagc gatgaaaaag gtggacttcc tgatcacaac 1434241 tggcggtgtg tcagtcggtg actttgactt tttgcctgcg atctatgaaa aactcggagc 1434301 ggacgtgctg tttaataaag ttgccatgcg cccgggcagc gtgacaacgg tggcgcatgc 1434361 aaacgatatg ctgctgtttg gcctttcagg taatccgtcg gcatgctatg tcggttttga 1434421 actgtttgtc aaaccgataa tccagacatg gctgctcaat gaaacaccgc attcaatttg 1434481 tgcggaagct gttttgacca aggattttcc gaagccgaac ccatttaccc gatttgttcg 1434541 tgcgctcgtg caccatcagg aagggaagct gttggcgaca cccgttggct tagataagtc 1434601 gagctctgtc acatcacttg cagatgccaa tgcatttatt atcctgccgg gcggtacgcg 1434661 aggctacgaa tctggcagaa cggttcaagt gctgctcatc agagaagaga atggaagtga 1434721 atggccttgg tccgtccttt cccgatcgtc caagttgtag gatttcaaaa cagcgggaaa 1434781 acaacgttta ttgagcgcat tcttgaaaaa gcctctgaac agggagtcca tttgggctgc 1434841 ctgaagcacc atggtcacgg cggtgaaccg caaacgctca cggaaggaaa agacacggac 1434901 cgttacaagg cggcaggtgc tgatgtaaca gcggtagaag gtgctggtgt gttacagctg 1434961 actgcccgcc gcaattggga tttggcacgg ctgattgagt tataccaatt tctcgaaaca 1435021 gactgtcttc tgattgaagg ctttaaaaaa gccccttatc ctaaagtggt tatcctaagt 1435081 gaaaaggaag atctggaagc gctgcaagca gtaaatataa tcgccatcat ctatagaaaa 1435141 aaagagcata tgacagagca tcagggatta cccgtttttc atgcggatga tccggttgcc 1435201 gtggattttg tgctttcaca gctgaagggg gaatctgcat aatggaacgg tttgagatta 1435261 cgaaaacacc cattaatact gaaaacatca tcaaaaaagt ggagaaacgg gaagcgggag 1435321 ccattacaac atttattggt acggttcggg aatggacaaa cggaaaaaga acggttcggc 1435381 ttgaatatga ggcatatgaa ccgatggccg tgcaaatgct tgctcaaatc ggcgctgaaa 1435441 tcgaagaaaa atgggaaggt gcctcagctg cgatcacgca ccgtataggt gtgctcgata 1435501 tcggtgaagc agcggtagtg attgctgtat cttctcccca tcgaaaagcc gcatatgaag 1435561 ccaatgagta tgcgattgaa cgcattaaac agattgtgcc gatttggaaa aaagaaattt 1435621 gggaagacgg tgagcaatgg atcggcgacc agctagaaac gacagcttat ccgaacggaa 1435681 aaccagacct aagcgaggga gagcagcatg attaaaattc ttttatttgc agggcttgct 1435741 gaacaggccg gtacacaagc aatagaaata gatatggaac aagcaaccac agatgaaata 1435801 aaagcgagtc taaaagaaca atacggtctt gaatctattg atacggctat gattgccgtt 1435861 aacgaaagct atgtaaaaga aaatacctct gtatcttcgg gtgacacggt agccatcata 1435921 ccgccggtca gcgggggatg aaaaccggac ggcatttcag ccgtccggtt tttctgtatt 1435981 tcattggcat atccccaagt atcctcagca tacaatgatt ttctgtaagc gtttattcta 1436041 catatgttac tccctataaa gtaagagact cactccataa ttagactgaa attttgaaaa 1436101 ataatagaaa tttatttcgg gtatcgatat agtgaagatg ataaatgttg gaaaggtgct 1436161 ggatatggag acatttaaaa gattaaaaat gtattattgg ccgtacagaa aagtgtttat 1436221 gtggtcgctt ctagccatgc ttttgatgac tgcaattact gtcgtttatc cgattatcct 1436281 gcaaattacg attgatgaga tcgtactggg acggcagtat cagcttgcgg cgtgggtcag 1436341 cttaggattt attgcggtga tggttttgaa aggaatggct accttttttc atcagtattt 1436401 aggtgatatg ttcgggatca aatccgttta tcggctgaga aatggtctgt atgaaaaact 1436461 gcagcggctt tctttttctt actatgataa cgcgaaaaca ggagatttga tgtccaggct 1436521 gactgctgat gttgaagggc ttcgtttttt cttatcatac ggtctcgctg agctcattcg 1436581 cttcggcctg ctggtagcca tcagcctgtc ggttatgttt tactattctg ttcctctcac 1436641 gcttgtgaca atagctgttc tgccatttct cgcggttgcg gtataccggt ttgacaaaag 1436701 agtccatccc gccttcagag gcatccgcaa atcgtttgcg aaactcaata caaaagttca 1436761 ggaaaatatc agcggcatta atacggttaa atctctttcc agggaagatt ttcagatcag 1436821 cactttcaat aaagccaatg cagaatacag ggcgcagtat ttacaaacat catccatttg 1436881 gtctgcgtat ttccctttaa tggagttcat tggtaacact tgtattgtag ctcttctctc 1436941 atacggcggt tacttggtta tgcaaaatca gctcaatccc ggcgagcttg ttgctttctt 1437001 cagccttgtc aattatatga tgtggcccat tatgaactta ggttttgtca tcaatatgtt 1437061 ctctcaagca aaagcgtcag gggaacgcct gctcgacatt ctggaaaaag aagaagacat 1437121 tacagatcat cctcatgctt tgcataaaca aaaattaacc ggagatgtcc atttcaaaaa 1437181 tgtttctctt gcatacggaa aagaacaaac aaacgcgctg tgcaatgtaa gctttgaggc 1437241 aaacagcggg aaggtaatcg gactgttggg cccgacaggt tcaggcaaaa gctcagtgac 1437301 acagcttctc accagatttt acagtcctgt tggcggaatg attaccattg atcacaaacc 1437361 catcacagat tattcgttaa aaacccttcg ctccaatatc ggggtcgtac ttcaagaatc 1437421 cttcctgttt tcatctacga ttagatcaaa tatttcgtat gggcggccgg atgcctcaat 1437481 ggaagacgtc atcgaagcgg caaaaagggc gcaggctcat aactttatta tggagcttcc 1437541 tgatgggtat gacaccatgc tgggagagag gggaatgggg ctttccggcg ggcagaaaca 1437601 gcgtattgcc attgcgagag ccatctgctt gaacccgagc attttaatat tggatgatgc 1437661 cacaagcgca gtagatatgc aaacggagca cagcatacag cttgccttaa aagaagtcat 1437721 gaaaaaccgc acaaccttta tcgtcgctca ccgcatttct tcactgaaac acgctgatga 1437781 aattctcgtt tttaataaag gacgcattcg tgaaagggga acacatcatg agcttcttga 1437841 aaaaggcggc tactataaaa agatttacga tttgcaatac cgtgatgtca aaatgattaa 1437901 tgagccgcat gaggtcggat agggaggggc caaatgaaac aagcgaaaaa acagggggtt 1437961 ttagagcgtt tctattactc ttcagatgaa atcattgaaa agccgtttaa ctgggctcaa 1438021 atgtggcggc tgctgagcta tgtcaaacca tatcgaaaaa caattttgcc gctttctttt 1438081 ctcactgtat tgattggcac tgctgtgaag cttgtgatcc ccattttgat cggcgtttat 1438141 gttcttgatc aagcgattac agggagaaac tcggagctgc tgattcagct catttttatt 1438201 attagcggtt tatatgtcct caattacgcc gccaatgtgt taagaatcag gtggatgaat 1438261 cagcttggcc agcatgtcat ttacgatttg cgacagcatt tatttaccca tgtgcagcgc 1438321 ttatcccatc gattttttga tcagcggtcg gcgggatcga tcttagtcag gatcatgaat 1438381 gatattaact ctcttcagga gctctttaca agcggagtca tcaatttgtt gaccgacttg 1438441 ctgcttctgg ccggcgtgat tattattttg tttacgctga gccctgagct gactatagcc 1438501 atcatggtga cattgccgat tatgtttttt atttcaacaa gtctcagaaa aaaaatacgc 1438561 cgatcctggc aaacggtacg gctgaagcaa tcgaagctca actctcatct aaacgaaagc 1438621 attcagggca tccgggtcac gcaggcattt acgcaggaag aagaaaacat ggcgtatttt 1438681 gacggtgtca atcaggagaa ctacgaatca tggcgggaag caactagaaa aaatgccatg 1438741 ttccgtccgc ttgtagaaat gacgaatgcg attgggacgg ctgtcttgat ttggtatgga 1438801 gccacactca tcatgaatga aaccattacg attggcgtct tcgtttcttt tgctttctat 1438861 ctgggaatgt tttgggaacc tatttcgaga ctgggtcagg tctataatca gctgttaatg 1438921 gggatggcat catcagaacg gatttttgag tttctggacg aacagccaaa tgtcaaggag 1438981 aagccgaatg ccattcataa tgaaaagata aatggggaga tcagttttga agaggttgaa 1439041 ttttcgtatg atgaaaaacg aaaagccctt cacgccgttt ctttctctat tcctgcggga 1439101 tcgacgcttg cgcttgtcgg gcatacaggg agcgggaaga cgacgattgc caatttaatc 1439161 agccgttttt atgatgcggc cggaggcacc attaaaatag acggtatacc gattaaggat 1439221 ctttcccttg ccagtctgcg ctctcaaatc agcattgtcc tgcaagatac atttattttc 1439281 tccgggacca tcatggaaaa tattcgtttt ggaaggccaa atgcttcgga tgaagaggtg 1439341 atgaaagcgt cccaagcggt cggagcggat gagtttattt ccgatttagc ggaaggatac 1439401 gcaacagagg tagaggaaag gggcagcgta ctgtctgccg gtcagcgcca gctcatttca 1439461 tttgcaagag cattgctcgc cgatccggct attatcatcc ttgacgaagc aacggcaagc 1439521 attgatacag agacagaagt aaaaattcag caagcgttaa aaacgcttct gaaagggcgt 1439581 acagcagtga tgatcgctca cagattgtct acgatccgcg acgccgaccg catcattgtt 1439641 cttgatcacg gcaggaaaat agaagaaggg aaccatgatc agctgctcgc taaaggaggc 1439701 atttatgccg ggcttgtgaa agcgcaatac agcacagcga tagaataata tgaaaagcct 1439761 tcaatattga aggtttttgg aaatttatta gaaaaacatg aaactttttg atatccttcc 1439821 cgtactattt gttagatatt ctcaaggagg ttttgaaatg gaaacgaatg tagaaaaaaa 1439881 cagcggaacg gcgactgaaa agccttcact tttcggagta atcacaagtc cgtccgttca 1439941 atttgaaaga ataagagaaa ggccggctgt atggggaccg cttttgattg ttgcagcaat 1440001 tatcatcgtc ggtgccgtgc tgcaatcact cggtacggat tatagtgagc ttttgaaaag 1440061 ccaggatacg caagggctat ctgctgaaca aatggaaact gtcgcaacaa taaccaaatt 1440121 tggcggaatg gcaggcgcta ttatcggcgg tatcgcagca ttatttattg cccctcttat 1440181 ttattggctc tgtgtaaaag tatcaggcgg tgttacgaca tataaaaaaa tgctttctct 1440241 cagtctgttt gtctctttga ttagcagtct cggattattg gttaatggaa tcgttgcttt 1440301 tacgactgac gtgaatcctc tttacagcac gacgtcactc gcagggatta tcccatctga 1440361 cggggctctc gccagtgtgt taaatacctt tgaaattttc agcatctgga gctttgtatt 1440421 attagcaatc ggacttcaca aaacgggagg catctcaaaa aaagccgggt ggatttcagc 1440481 aatcattcta ttcggaattt tagttgtatt ttcgcttttt tcaggtttaa tcaattctgt 1440541 ggcgggtgca taagctcatg aaaaaagtct ggatcggaat tggaatcgca gttatagtcg 1440601 ctctttttgt tggaatcaat atataccggt ctgccgctcc gacaagcggc agcgccggca 1440661 aggaggtaca gacggggagc gttgaagaaa atgaaatctc atcaacggtt atggttcctg 1440721 gcacgctaaa attttcaaat gaacagtatg tcttttatga agcggataaa gggacattag 1440781 aagacattaa agtaaaggaa ggcgataaag ttaaaaaggg cacggcttta gtcacctata 1440841 caaatgagca gctgagcctg gaaaaagaac agaaccagtt aacgtctgaa tccaaccggc 1440901 ttcaaattga ccaaattcaa gaaaagttaa aagccttgga cagcaaagaa agagaactgg 1440961 aaaaacaggt aggaaagaaa gaagcagaaa aacaaatcga atctgaacgg acagagcttc 1441021 aaatgcagaa aaaaacagcg gagatcgaat taaaacaaac cgagcttcag cggcagtcac 1441081 ttgccaaccg ggtgtcagat ttagaagtga aaagcgaaat tgaaggcacc gttatttctg 1441141 tcaaccaaga agcggcatcc aaaaagtcag atattcaaga gcctgtcata catatcggca 1441201 acccaaaaga ccttgtcgtc tcagggaaat tgtctgaata cgatacattg aaagtcaaaa 1441261 aaggccagaa ggtcacactc acttcagatg taatacaggg taaaacatgg aaaggcacgg 1441321 tttccgcagt cgggcttgtt ccggatcagc aggagagcgc tgcggcacaa ggaacagaac 1441381 aggcggtcca atacccgctt caagtgaaaa taaaaggaaa tcttccagaa ggaaagccag 1441441 gctttaaatt tatcatgaat attgaaacag ataaacggaa agcaaatacg cttccttcaa 1441501 aggcagtcaa aaaagaagat gaccaatatt atgtgtatac agtaaaagac ggaaaagcaa 1441561 agcgagttga tgtcaaaatc ggcgaagtga cagatgacct gacagaaatt aaagaggggc 1441621 ttacccaaga tgatcaagtc attttgaatc catctgatca ggtgactgac ggaatggaag 1441681 tgaaatccta aatgattcag ctttctaatg tgcgaaaaag ctaccagatc ggaaaggaaa 1441741 cgtttgatgt tctccattct attgatttgg acattcatca aggtgaatat gtctcgatta 1441801 tggggccgtc aggatcagga aaatcgacga tcatgaatat tatcggctgt cttgatcggc 1441861 cgacttccgg tacatatcaa ttggacggcg aagacatttc ttcatataaa gataaagaac 1441921 tggcggcagt ccgtaaccgg tccatcggtt ttgtatttca gcaatttcag cttcttccgc 1441981 ggctgaacgc aaaaaaaaat gtcgagctgc cgatgattta ttccgggata ggcaaaaagg 1442041 aacgtcaaga gcgggctgag agagcattgg aaaaggtcgg gttagccgat cgaatgctcc 1442101 acatgcccaa cgagctgtcg ggcgggcaga agcagcgggt ggcgattgcg agggcgatcg 1442161 tgaatgagcc gaaattgatt ttagctgatg aaccgaccgg cgcgctggat acgaaaacaa 1442221 gcgaggcgat tatggatcag tttacagcat taaatgccga gggaacgaca atcgttctgg 1442281 ttactcacga gcctgaagta gcagattgca cgaatcggat cgtcatggtg cgtgacggaa 1442341 acattgttcc tgccagctcc ggacaaagga gtgtgggaga atgagcctgt tggaaaacat 1442401 cagaatggct ctaagctctg tccttgccca taaaatgcgt tcgatcttaa cgatgctcgg 1442461 cattatcatt ggtgtaggct ctgtcattgt tgtcgttgcg gtaggacagg gcggcgagca 1442521 aatgctgaag cagtcgatca gcggcccggg aaatactgtg gagctgtact atatgcctag 1442581 cgacgaggag cttgcaagca acccgaatgc cgcagctgaa tctacgttta cagaaaacga 1442641 tattaaaggt ttaaaaggaa tagaaggcat taaacaagtc gttgcttcga cttctgaaag 1442701 tatgaaagcg cgttatcacg aagaagaaac cgatgctacg gttaacggaa taaatgatgg 1442761 atacatgaat gtcaattctt tgaaaatcga aagcggcaga acctttaccg acaatgactt 1442821 tctcgcgggg aatagagtcg gaatcatctc tcaaaaaatg gctaaagagc tgtttgataa 1442881 aacctcccct ctaggtgaag ttgtctggat taacggacag cccgttgaaa ttatcggcgt 1442941 gctgaaaaaa gtaacaggct tgctttcttt cgatttaagt gaaatgtatg tgccatttaa 1443001 tatgatgaaa tcctcttttg gcacaagtga tttcagtaac gtatcattgc aggtcgaatc 1443061 agcagacgac ataaaatcgg ctggaaaaga agcggcacag ctggtaaatg acaatcatgg 1443121 cacagaggat tcgtatcaag tgatgaacat ggaagagatt gcggccggaa ttggcaaagt 1443181 aactgcaatt atgacgacga ttatcggctc aattgcaggt atttcccttt tggtcggcgg 1443241 aatcggtgtc atgaatatta tgctcgtatc agtcacagaa cggacgcggg aaatcggaat 1443301 cagaaaatca cttggtgcga cgaggggaca gattctgact cagtttttaa ttgaatcagt 1443361 cgtattgacg ctgattggcg gtctggtcgg gattggtatt ggatacggag gggccgcgct 1443421 tgtttcagcc attgcgggct ggccgtcact catatcctgg caggttgtat gcgggggcgt 1443481 gctgttcagt atgctcattg gtgttatttt cggcatgctt cctgcaaata aagccgcaaa 1443541 gcttgatccc attgaagcgc tgcgttatga gtagcctcat gcaacatgca tgaggttttt 1443601 ttatgtttag tgatttctac tatgaatata aaagactttt ttcattaaaa taagaagaaa 1443661 atgtcgtaca attgtcctta tttttgtcga atttacagtt tacaaaccct atagacatac 1443721 gttaatatgg agaaacgtga aagattttga tagttattga atgaatttga atgattttag 1443781 ttgcctaaac cgaaaatagc gtttacaatg aaattgtatt caaaatgaat acgttttcat 1443841 taggaggtga agcatgctaa ctcctgaacg gcatcaattg attattgatc aaatagaaaa 1443901 gcatgatgtg gtaaagattc aagagcttat aaatctgact aatgcttctg aatcaacaat 1443961 cagaagagat ttatcgaccc ttgaagaacg cggtttttta aagcgcgttc atggtggagc 1444021 ggccaagctt tccgatatca gacttgaacc cgatatgctt gaaaaatcat ccaaaaacct 1444081 tcacgataaa ctgaagattg ctgaaaaagc tgcttctctt ttagaagaag gggattgcat 1444141 ttaccttgat gcaggcacga cgacattgca catgattgat tttatggata aaaccaaaga 1444201 tattgtcgtt gtcacaaacg gggtaatgca tatcgatgca ttaataagga aagaaatttc 1444261 tttttatctg cttggaggat acgtaaagca cagaacgggc gcgattattg gaggcgcttc 1444321 attggttgcc atggaccagt acagatttga caagagtttt ctggggacaa acggtgtcca 1444381 tacagaggct ggatttacaa cgccggaccc tgatgaggcc cttttaaaac agaaagcgat 1444441 caaacaggca aaacacgctt acgtcttagc agacccttcg aagttcggag aaatttcatt 1444501 ttcggcattc gccggaatag gcgacgcaac aatcattacg actgacgctg aagagcttac 1444561 attcgataat taccaagaaa aaactgtcgt aaaggtagtg aaaccatgat ttacactgta 1444621 acacttaatc catctgtcga ttatatagtt cacgttgaag attttactgt aggaggcctg 1444681 aaccgttctt cgtatgatac caagtatcca gggggcaaag gcatcaacgt atcgagactg 1444741 ctgaaaagac accatgtggc gtctaaagcg ctcggattcg tcggcggatt taccggagaa 1444801 tatatcaaaa catttttacg ggaagaaaac ctggaaacag ctttttctga agtaaaaggg 1444861 gatacccgta tcaatgtaaa gctgaaaacg ggtgatgaaa ctgaaattaa cgggcaggga 1444921 ccgacaattt cggatgaaga tttcaaagcc tttttagaac agttccaatc tttgcaagag 1444981 ggagatatcg ttgttcttgc aggaagcatt ccatcttcac tccctcacga tacttatgaa 1445041 aaaatcgcag aggcctgcaa acagcagaac gcacgagttg ttctggatat ctcaggcgag 1445101 gctcttttga aagcaacaga aatgaaacca tttttgatga agccaaatca tcatgagctt 1445161 ggagaaatgt tcggcacggc cattacatct gttgaggaag ccgttcctta tgggaaaaag 1445221 cttgtagaac aaggcgctga acatgtaatc gtatcaatgg ccggagacgg agcgcttctg 1445281 tttacgaacg aagctgttta ttttgctaac gtgccaaagg ggaaattggt aaactcagtc 1445341 ggagcagggg attccgttgt tgcaggtttc cttgccggaa tttccaaaca gctgccgctt 1445401 gaagaagcat tccgcttagg agttacttca ggcagtgcta ccgcgttctc tgaagaactt 1445461 ggaacagaag aatttgtcca gcagcttctt cctgaagtta aggtcacacg tctatagagg 1445521 aggaaacaca agtgaaaata actgagcttt taacgaagca tacgataaag cttaatattg 1445581 agagcaaaga aaaagaaaat gttattgacg aaatggtcac tgttcttgat aaggctggaa 1445641 agttaaatga ccgacaagcc tataaagaag ccattttaaa tcgcgaaagc caaagctcca 1445701 cgggtatcgg tgaaggaatc gctatccccc atgcgaaaac ggcaagcgtt atcaacccgg 1445761 cgatcgcgtt cggacgttca aaagacggcg tcgattatga atcattagac ggccagccgg 1445821 ctcacttagt gttcatgatc gcggcgactg aaggcgcaaa caacactcac cttgaagcat 1445881 tgtcaagact ttcaacgctg ttaatgcgtg aagaaatccg taagcagctc cttgaagctg 1445941 agtctgaaga tgccatcatc gacattatta atcagcacga taaagatgat gacgaagagg 1446001 aagaggaaga agaagcggca ccagcacctg ccggaaaagg gaaaatttta gcggttactg 1446061 catgcccgac aggtattgcc catacattca tggctgcgga tgcccttaaa gaaaaagcga 1446121 aagagcttgg tgtggaaatt aaggtcgaaa caaatgggtc aagcggcatt aagcacaagc 1446181 tcactgccca agaaatcgaa gatgcacctg caatcattgt cgcagcggac aagcaggttg 1446241 aaatggaacg ttttaaaggc aagcgcgtac ttcaagttcc tgtaacggcg ggtatcagac 1446301 gtccgcaaga gcttatcgaa aaagcgatga atcaagatgc gccgatttat caaggcagcg 1446361 gcggcggttc agcagcttca aatgatgatg aagaagcgaa aggcaagtct ggaagcggta 1446421 tcggaaacac gttttataag cacctgatga gcggtgtcag caacatgctt ccgttcgtag 1446481 tcggcggcgg tattctcgtt gcgatttcat tcttctgggg aattcactct gctgatccga 1446541 atgatcctag ctacaacacg tttgcagcag cattaaactt tatcggcggc gacaatgcat 1446601 taaaactcat tgttgcagtt ctggccggtt tcattgcgat gagtattgca gatcgtcctg 1446661 gttttgcgcc tggtatggtc ggcggattta tggcaactca agcgaatgct ggattcttag 1446721 gcggcttaat tgccggattc cttgccggtt atgtcgtgat tttactgaaa aaagtattta 1446781 cgtttatccc tcagtcactt gatggattaa aacctgtttt gatttacccg ctgttcggta 1446841 tttttatcac tggcgtatta atgcaatttg tcgtcaatac acctgtagcg gcatttatga 1446901 atttcttaac aaactggctt gaaagccttg gtactggaaa ccttgtgtta atgggtatta 1446961 tcttgggcgg catgatggcg atcgatatgg gcggtccgct taataaagca gcctttacgt 1447021 tcggtatcgc catgatcgat gcaggcaact atgcgcctca tgcagcaatc atggccggcg 1447081 gtatggttcc tccgcttggt atcgcacttg caacaaccat tttcagaaac aaattcactc 1447141 agcgtgaccg tgaagctggt attacatgct atttcatggg agctgctttc gtaacagagg 1447201 gagcgatccc atttgctgcg gctgatccgc ttcgcgtcat accagctgct gtagtcggtg 1447261 cagctgttgc cggcggatta actgaattct tccgagtaac gcttccggcg cctcatggag 1447321 gagtattcgt agctttcatt acaaaccatc cgatgcttta ccttttaagt atcgtgatcg 1447381 gtgctgtcgt gatggcaatt atcctcggta tcgtcaaaaa acctgttaca gaaaaataag 1447441 aaaaaaagcg tccttggttc gaaaggacgc tttttcttat ccggccggca gggagcgcgg 1447501 ttaagttatg tattttattc ttttttatga taaagtaaaa gaagagaaac aactgacata 1447561 gcaattgtct aggaggaaac actttgaccg aggaaaaaaa tacgaatact gagaaaacgg 1447621 cgaagaaaaa aaccaatacg tacctggaat ggggtaaagc gattgtcatc gctgttctgc 1447681 tggctctcct gatccgtcac tttttgtttg aaccgtattt agttgaaggt tcatctatgt 1447741 atcccacatt acatgacgga gaaaggctgt ttgtgaataa aacagtcaac tatatcggcg 1447801 agctgaagcg cggagatatc gttattatca acggtgaaac ttctaaaatc cattatgtaa 1447861 aaagattgat cggaaagcct ggagaaaccg ttcaaatgaa ggatgacacg ctttatataa 1447921 acggtaaaaa agtagccgag ccttacttgt ctaaaaacaa gaaggaagca gaaaaacttg 1447981 gtgtcagtct gacaggagac tttggaccgg ttaaggttcc gaaaggcaaa tactttgtca 1448041 tgggagataa ccggctgaat tctatggaca gccgaaacgg gctgggactg atcgcggaag 1448101 atcgaattgt cggcacatcg aagtttgtct ttttcccgtt taacgaaatg cgtcaaacaa 1448161 aataaaaacg ccttgctggc ctaggacagc aggcgttttt attttgaaaa agaagcgacc 1448221 aatgcaatgc ataaaaccgt gatgaacact gaaccgataa tagccagcac actgaagaaa 1448281 aggtgaacct gtttgttctc ttttccgcgc ttttctaata gccgtttaga aaaaatgtgc 1448341 gaaaatatgt aaataagggc tatgcctata tataagccga tatctttggc ggtaaagcct 1448401 gttacggcaa ggtaaaagcc cgtaaaaaag atcagtaagc aatattcagt aagtgttaaa 1448461 agcctcaacg tgttcctcca tgagagtgtg taattttcca ggcggatgca ttctctctct 1448521 ttaattgtaa cacagctggc tggtttgggt gtataagtgt tttctctctg ttttatcagg 1448581 gaatcatttc tcttgccctg cattcatggt atacttttat tgatgataga catgatggag 1448641 gataataaat gattgctgta aataatgtaa gcttgcggtt tgcggatcgc aagttatttg 1448701 aagatgttaa tattaaattt accccaggca actgctatgg gttaattggt gcaaacggtg 1448761 ccggtaaatc aacgtttcta aaggtgctgt caggcgaaat cgagcctcag acaggcgacg 1448821 tgcatatgag tcctggcgag cgtcttgccg tcttgaagca gaaccatttt gagtacgaag 1448881 agtatgaagt gctgaaagtg gtcattatgg gccacaaacg cctgtatgaa gtcatgcagg 1448941 agaaagacgc tatttacatg aagcctgatt tctcagatga ggatgggatt cgtgctgctg 1449001 agctagaagg tgaattcgcg gaactgaacg gttgggaagc ggaaagtgaa gctgcgatcc 1449061 tgttaaaagg ccttggtatc tcagaagatc tgcacacaaa aaagatggca gacctcggcg 1449121 gttcggagaa ggtaaaagtt ctcttggcac aggcattatt cggcaagccg gatgttctgc 1449181 tgctcgatga gccgacgaac cacctggacc ttcaggcaat tcagtggctt gaagagtttc 1449241 tgattaactt tgaaaacaca gttattgtcg tatcccatga ccgtcacttt ttaaataaag 1449301 tatgtacgca cattgccgac cttgatttta acaaaattca aatctatgtc ggaaactatg 1449361 atttctggta cgagtcaagc cagctggcgt taaagctttc tcaagaagcg aacaagaaaa 1449421 aagaagagca gattaaacag cttcaagagt ttgtcgctag attcagcgcc aatgcgtcta 1449481 aatctaagca ggctacatca agaaagaaac ttctcgaaaa aatcacgctg gatgatatta 1449541 aaccgtcttc ccgccgctat ccttatgtta acttcacgcc ggaacgggaa atcggaaatg 1449601 atgttcttcg cgtggaaggc ttaacaaaaa caatcgatgg cgtaaaggtg cttgacaatg 1449661 tcagctttat tatgaatcga gaagataaaa ttgctttcac tggccgaaat gaacttgctg 1449721 ttactacgct gtttaaaatc atttccgggg aaatggaagc tgacagcgga acgtttaaat 1449781 ggggtgttac cacatctcaa gcgtattttc caaaagacaa cagcgaatat ttcgaaggca 1449841 gtgatctgaa ccttgtagac tggcttcgcc aatattctcc gcacgaccaa agtgagagct 1449901 ttttacgcgg tttcttagga cgcatgctgt tctctggaga agaagtccac aaaaaagcaa 1449961 atgtactttc cgggggagaa aaggtccgct gtatgctgtc gaaagcgatg ctttctggcg 1450021 ccaatatttt aattttggat gagccgacca accatttaga cctagagtcc attacagcgc 1450081 tcaataacgg cttaatcagc tttaaaggcg ctatgctgtt tacttcccat gaccatcagt 1450141 ttgtgcagac cattgccaac agaattatag aaattacacc taacggcatc gtcgataagc 1450201 aaatgagcta tgacgagttc cttgaaaatg ctgatgtgca gaaaaaattg actgaactat 1450261 acgccgaata aaaaagcaga gatttctctg ctttttttga tacctaaatg tgaaaggaga 1450321 tcacaacatg aaatttttgg ttgtcggagc aggtggagta ggcgggtata ttggcggacg 1450381 gctttcggag aaaggaaatg atgtgacatt tctcgtgcgc caaaaacgag ctgagcagct 1450441 taaaaaaacc gggcttgtca tccatagtga aaaagggaat gtatcatttc agcccgaact 1450501 aatcagtgcc ggagaaacag ggcaatttga tgtcgttatc attgcttcta aagcatactc 1450561 gcttggtcaa gtgatagagg atgtcaaacc atttatccat caagaatctg tcattatccc 1450621 ttttttaaat gggtaccgcc actatgagca gctatttgcg gcattttcaa aagaacaggt 1450681 gctgggcggc ctgtgtttta tagaaagtgc tttagacaac aaaggagaaa ttcatcatac 1450741 gagcgcatcg catcgttttg tatttggaga atggaacggc gagcgtacgg agcggataag 1450801 agcgcttgaa gaggcatttt caggtgtgaa ggctgaagtc atcattagcg ggcatatcga 1450861 gaaggacatt tggaaaaagt atctctttat tgcagcgcaa gcggggatca caacgttatt 1450921 tcaacgaccg cttggcccaa tcctcgccac agaagccgga cgtcacacgg cccaaactct 1450981 tattggggaa atttgcactg ttttacgaaa agaaggtgtt ccggctgatc cggctcttga 1451041 ggaagagagc tttcgtacga tgaccagcat gtcttaccat atgaagtcct ccatgcttcg 1451101 ggatatggaa aacggccaaa cgacagaagg cgaccacctg catggatttt tgattgaaaa 1451161 agcaaaacgt ttatctctcg ctgcaccagt attagaaacc gtttatgcga atctgcaaat 1451221 gtatgaagca gaaaaataaa aaaaggaggc ggaaaagcct ccttttattt acttaaaaag 1451281 cccaatttcc gtttctgaag ataggctctc ttttcccgtc tgccgtaatt ccgtcaatat 1451341 tcatatcctt agaaccgatc ataaagtcca cgtgtgtaat gctttcattt aggccttctt 1451401 tgacaagctc ttcacgagac atctgctttc cgccttcaat attaaaggca taggcgcttc 1451461 cgatcgccaa atgatttgac gcgttttcat caaacagcgt gttatagaaa agaatgtttg 1451521 attgtgatat aggcgaatcg taaggaacaa gtgccacttc acctaaatag tgagaacctt 1451581 catctgtttc caccagttct tttaaaatat cctcaccttt ttcagcttta atgtcgacta 1451641 tacggccatt ttcaaacgtc agggtgaaat tttcaataat atttccgccg tagcttaatg 1451701 gttttgtgct tgataccact ccgtcaaccc cgtctttttg cggcagcgtg aacacttctt 1451761 ctgtcggcat attggccata aactcatggc cactttcatt cacgcttccc gcacctgccc 1451821 aaacatgctt cctaggcagc ttaattgtta gatcagttcc ttctgcttga taatgtaagg 1451881 cagcgtaatg tctctcgttc aaatggtcaa ctttttcatg aagattttgg tcatgattga 1451941 tccacgcctg aaccgggttg tcttcattta cgcgcgtcgc tttaaaaatt tcttcccaca 1452001 gaaggtggat cgcttcctcc tctgatttgc caggaaacac cttgtgagcc cagcctgctg 1452061 atgccgcacc tacgacagtc cagctgactt tgtctgattg aatatattgt ctgtatgtat 1452121 gtaatgcttt gcctgctgct ttttggaatg ccgcaatccg tttggaatct atacctttta 1452181 gcaagtctgg gttcgacgac acaacagaaa tgaaagcagc tccatttttg gcaagctctt 1452241 ctctgccttt tgcttcccat tcaggatatt cttcaaatgc ttcaaacggc gcaagttcgt 1452301 attttaattt ggcgacttcg tcatcctgcc aattcacggt gacgtttttt gcgccctttt 1452361 catatgcgtg ttttacaatt aaacggacaa aatcccgaac gtctgttgaa gcatttacga 1452421 ctacatactg gcctttttgg acattaacgc cgacttctac cgccagctgt gcatatgtat 1452481 ttaatttctg tgaaaatgaa tccatgaatc attcctccaa gcttttttct catcatatca 1452541 aatatgatcc tataaaggaa agaaggagcc caaagtgaaa aacccaaaac gacacgtctt 1452601 gggttttttc aatattatgg atgattcagt tttacagtgc cgcctgcagg cgaatggggc 1452661 atatttgcca aagaaatgct catgcctcca agaataattc cgcttaaaat ggctgcgatc 1452721 gctactcttc ttcctaaatc tcttagcatc tgtttcctcc ttaacgtttc tccatttccc 1452781 acaatatgaa ggaagtgagg aaaaaagaag caagaaattt gccgcgtgtg agaattttgc 1452841 gggtaaagac tatttaattg ccttttgcag cttatcaatc acttctaaag aacggcctgt 1452901 gccgattgct acagattcaa gcgggttttg cgccacgtgt acaggcacga caatctcttc 1452961 tgtgagccat tctttaattc cattaaggag cgcgccgccg cctgttaaaa taacgccgcg 1453021 atcaacaata tctccgctca attcaggcgg acagtcctca agtgtcgctc tgatggcttc 1453081 aagaatatgc aggagggatt cacgcattgc atcttgaatt tcgttggatt gaagcataat 1453141 ggtttttgga agacctgtca cgaggtcacg tccccgaatt tccattgcct ctggtatatg 1453201 ttcaatcaga gcatggccaa tttccatttt tacctgctca gctgtgcgtt cgccgatcag 1453261 caaattgtat tttttacgga cgaaagaaac gatatcctca tcaagctggt ctccgccgat 1453321 cctgatagaa tggcaggaaa caacgccacc gaaggaaata atagcgacct ctgtcgtccc 1453381 tccgccgata tctactacca cattggcaac cggctcatca accggtaaat ccgctccgat 1453441 ggcggctgca actggctctt cgattaaatg aacgtttttc gcgccgcaat ttttcaccgc 1453501 atcactgatg gcgcggcgtt ctactgctgt tgagcctgat ggtgtgcaaa cgactacgtt 1453561 cggttttctg aacgacatgc cgatgctttt tgcggctttt ttcataatgt gctttagcag 1453621 gtcagttgtc atatcatagt ctgcgatcac gccatctttc atcggtctga cagcgacaat 1453681 ttttcccggt gttttaccga tcatgttttt cgcgtcagct ccgattgcaa gcactgcttt 1453741 tgtcgtcgta tccactgcga caacagatgg ttcatttagg ataatccctt tatttttgct 1453801 gtaaacaagt atattagctg ttcctaagtc aatcccgatt tcagttgatt gaaacatgtt 1453861 ttcacccaat ctctatccta atttaatatg attctacatt taaagtttct cagaaatact 1453921 gcgatttttg ggggtgtgcg tcggtaaaga aatgtttttg taaaaaatca aggaactgtg 1453981 taacagaagt aatacatttt tcggttttat ggaaaaaata tcttgtaatt cttatagaaa 1454041 gcgggaaact ttttcaaagt ttcattcgtc tacgatatat tgaggtacat ccttaaaaca 1454101 ttacatgaga aaagaaacat ttaaaggaag aagggttttt atgaaatcaa taggtgttgt 1454161 gagaaaagta gatgaattag gccgcattgt catgccgatt gagttgagac gggcattgga 1454221 tattgccata aaagacagca ttgagttttt tgttgacgga gataaaatta tcttgaaaaa 1454281 gtacaaacct catggcgttt gtttaatgac tggagaaatc acttcagaaa ataaagaata 1454341 cggcaacggt aaaattacgc taagccctga gggtgcacag ctgcttctcg aagaaattca 1454401 agccgcttta aaagaataaa attatgctaa aaaaggcgga gtgatatcat ctccgccttt 1454461 tttgcgtgcc aatttttgat taccgccgcc taagataaga catcaagata tttggtaatg 1454521 aatgatttgg gatactttac atattttact caattatttg tcgaagaatg gtacaataag 1454581 tagagaaaca caagcggcag gtggtcatat gagaaaatat caagctcgta tcatttccat 1454641 cattttggca atgattttta taatgttttg ggattattta ttttatttta taggcaaaaa 1454701 cccgattaat tggcctgttg atattgtgta tactgcagtc acgctggtaa gtgtctggat 1454761 gttggcttat tatattgatg agaaacagca gctggttaag aaaatgaagg ataacgaatg 1454821 gaagtataaa cagctttctg aagaaaaaaa ccgcatcatg gataatttgc aggaaatcgt 1454881 atttcaaacg aatgcaaaag gtgaaattac atatttaaac caagcgtggg catctataac 1454941 cgggttttca atcagtgaat gtatgggaac aatgtataac gattacttca taaaagaaaa 1455001 gcacgtagcc gaccacatta acacccaaat ccaaaacaaa gcgtcttctg gcatgtttac 1455061 ggcaaaatac gtgacaaaaa acggcacgat tttttgggga gaagttcatt ataaacttta 1455121 ctatgaccgg gatgaccaat ttacaggcag cctgggtaca atgtcagata tcactgagcg 1455181 gaaagaggct gaagatgagc tcattgagat taatgaacgg ctggcgaggg aatcccagaa 1455241 actatcaatc acaagtgaac ttgccgcagg tattgctcat gaggtcagaa accctttaac 1455301 atctgtcagc ggtttcctcc agattatgaa aacacaatat ccggacagaa aagactattt 1455361 tgacatcatc ttttcagaga ttaaaagaat cgatttagtg ctcagcgagc tgctgctgct 1455421 tgcaaaaccg caggcaatca catttaaaac acaccagctt aatgagatct tgaaacaagt 1455481 cacgacattg cttgatacca atgcaattct gtccaatatc gtcatagaga aaaatttcaa 1455541 agagacagat ggctgtatga ttaatggaga cgaaaatcag ctgaagcagg tctttatcaa 1455601 catcattaaa aacggaattg aggcaatgcc aaagggcggt gtcgtaacca tttcaactgc 1455661 taaaaccgcc tctcatgcag tgataagcgt aaaggatgaa ggaaacggca tgccgcagga 1455721 aaagctgaag cagattggca aaccttttta ttcaacaaaa gaaaagggca ctggactggg 1455781 acttcccatt tgtttgagaa tcctgaagga acatgacggg gaattgaaaa tcgaaagtga 1455841 agctggaaaa ggcagcgtct ttcaagtggt tttgccttta aaatcagaca gctgagagga 1455901 gaaaaataaa gtgaactcgc ttctgtttgt atacgggaca ttaagaaagc atgaaaaaaa 1455961 ccatcatttg ctggcacaat cggcatgtat caatgagcag gcgagaacaa agggaagttt 1456021 gtttgctgca aaagaggggc ccacagttgt tttcaatgat gaagatgaag gctatatata 1456081 tggcgaagta tatgaagcag atgaattgtg tatacataag ctcgatcaat tttttcaagg 1456141 atatcataaa caaacggtgt ttgtagaaac ggatgtcggg attaaaattg cgcttattta 1456201 ttttatgaac aaagacgggt gtgccggttt tacgaaaata agcagcggcg actggaaaga 1456261 acatcagatg atcagcaaat cgaaaaatcc catttattat tttgcctatg gatcatgcat 1456321 ggataatgcc cgctttcaaa aagcgggagt cgatcactat tttcaagatc cagtaggaag 1456381 agctgtttta aaaggataca caacccgctt cacgctaaaa agggaagacg gttcaagagc 1456441 ggacatgttg gaagacggag gaacaacaga aggcgtttta taccgtatcc cttattctgc 1456501 tctctcctat ctatataaaa gggagggcgt cgaatctctt acgtatcggc cggcatttgt 1456561 agacgttgaa gctggcggaa ggcactacaa agactgttta acctttctcg tcctccaaaa 1456621 agaagcggaa attgccccgc ctcagcacta tcagattgaa atcgaacgcg gagcggagct 1456681 gtatttgtcg cctgagttta ctgaaaagct caagcggcat atgaattcgc tgccaaaagg 1456741 ataacactgt aacaaaagaa tatgataaaa tttgatcaat atcatgtcat ataaaggagc 1456801 accacgatga aaaaagaatt tgcggtaatt gggctgggcc gttttggtgg cagtatttgc 1456861 aaagcattaa gcgaagaagg cgtcgaggtt atggcaatgg atatcgatga agataaagtc 1456921 aacgagtatg ccaagattgc atctcacgca gttatcggtg attcgacaga cgaatctgtc 1456981 ctgaaaaatt taggcctgcg aaattttgac cacgttattg tagcaatcgg ggaaaatatt 1457041 caagcgagta ttttaacgac actcattctg aaagaacttg gcgtccatac gattacagtt 1457101 aaagcgcaga acgattatca cgaaaaagtg ctgtctaaaa ttggtgcgga tcacatcgtc 1457161 cacccggaac gcgatatggc aaaacgaatt gcgcataata tcgtgtccaa caatgtactt 1457221 gactatttgg agctgtctga agagcatagt cttgttgaaa tcgtagctaa cagccgcctg 1457281 gctggaaata cgcttctcga tttagatatt cgcgcaaaat acggtattaa catcgtagcc 1457341 ataaaaaggg gcaaggaagt catcgtatca ccgcttgcaa ccgaagtcat ccaccaagaa 1457401 gatatactca ttgttattgg atcagttaca gacatctccc gtttcgaaaa aagagttctt 1457461 catacaaaat agcagccaaa taagccgtcc tcaaagggcg gtttttcata ttatcagaat 1457521 ataacaactt taatgaactg agcgtcaatt tcttaaaatt tcattgacta agcacaggcg 1457581 ttccgatagc atattgtacc atataataaa aaaaggaggg gcctatttga ataaagaagc 1457641 gctagtcaat aggctgaatg cttcagccaa aagacaaaaa gctgatatcg tcattaaaaa 1457701 cggaaaaatc atggacgtat ataatcaaga atggatatat gaagatattg cgattacaga 1457761 tggagttatt gtaggcctcg gtgagtatga aggcgaaaat atcattgatg cagagggaca 1457821 aatgattgtt ccgggtttta ttgatggaca tgtacatatt gagtcgtcaa tggttacacc 1457881 gattgagttc gctaaagcag tgttgcctca tggcgtgacg acggttgtta cagatccgca 1457941 tgagatcgcg aatgtgtctg gtgaaaaagg gattgagttt atgcttgaac aagctcggca 1458001 tacaccgctg aatatccatt ttatgcttcc ttccagtgtg cctgccgcaa gttttgagcg 1458061 atcaggcgca attctcaaag ctgccgatct caagcctttt tatgaagaag aagaagtatt 1458121 agggctggct gaagttatgg attatgtgtc ggttcagcag gctgaaaaag acatggttca 1458181 gaaactgctt gatgcccgtg tggcaggaaa aaggatagac ggtcatttag ctggtttatc 1458241 aacagacctc attaacattt acagaaccgc atttgtctta aacgaccatg aagtaacatc 1458301 gaaggaagaa gcccttgatc gtatcagaag gggcatgtat gtcatgatgc gtgaaggatc 1458361 agtcgccaaa aacacgctca atgtgctgcc ggcggtgaat gaaaagaacg cacgccggtt 1458421 ctttttctgt acggatgata agcatgtgga tgatttattg tcagagggaa gtgtaaacca 1458481 tcaggtgaaa atggcgattc aagccggact taatccgttt ttagcctatc agctaggaag 1458541 cctcaatgca gccgaatgct acggattaga tacaaaggga gcgattgccc cgggttttga 1458601 cgctgatttg ctttttgtat ctgatctgga aaatgtcact gtcacaatga cgatggtaaa 1458661 agggcagact gttgctgaag acagcaaagc ggtctatcag gatcatgctt caactgcagc 1458721 accagatcag gcactgcttg attctgttaa gcttgctgct cctcttaaca aacaggattt 1458781 tcatatgcca atcgattcag agcagcagat caatgtcatt caaatcatac caaatcagct 1458841 tgaaacacga ttagtacaag ttccggctcc tgttgcccgc gaatttgagc ctgacactga 1458901 gcttgatttg ttaaagattg cagttgtcga gcggcataaa ggattaaaag aaaccggact 1458961 tggtgttgtg aaaggttttg gattcaagag cggagcgatt gccacaacca tttcacacga 1459021 ctcccataat attattgccg tcggaacgaa tgatgaggat atcgcggcgg cagttaataa 1459081 gctgcaggaa attggcggag gattaacaat tataaaaaat ggggaagagc tccattcagt 1459141 accgctgccg attgcagggt tattatccga ccaatctgca gagcaagtga atcaaagctt 1459201 gctgacgctt catgataaat tgtcgttaat cggtttcaca ggcggattta atccattttt 1459261 gacattgtcg tttttagcgt tgcctgtcat tcctgatatt aaaatgacga ctacgggatt 1459321 attcgatgta aaatcatttc aacacatatc actgcaataa aaagaggcac tcccttaggg 1459381 agtgcctctt tttttaaacc tccataatga tcggcaggat cattggacgg cgctttgttt 1459441 tttcgtacaa gaaaggtgca agcgtgtctg taatttcgtt tttgatttca gaccattgag 1459501 tcgtttttcg ttccattact ttttgtaagt gatttgaaat gagctcttga gcgtcgttga 1459561 tcaagtcacc agattctctc atgtacacaa atcctctgga aatcaaatca ggacccgctg 1459621 aaatcttgaa gtcgtccatg tcaatgctga caacaacgat gacaagtcct tcttcagaga 1459681 gaattctgcg atcacgaagt acgatattgc caatatcacc gataccgctt ccgtcaatgt 1459741 acactgaacc ggacgggatt tttcctgcaa ctgaagcctc atcgccttta agtgctaata 1459801 cttcaccatt atccatgata aagcagtttt cctctgggat gccacaatct gttgcaagtt 1459861 tgacatgcat cttttgcatt ctgtactcac cgtgaatcgg catgaagaat ttaggcttga 1459921 ttaaacgaag catcagcttc tgttcttcct gtccgccgtg accggatgta tggatatcgt 1459981 taagagggcc gtgaataacc tcagcacccg cacgatacag ctggttgatt gttcgactca 1460041 cgctgattgt gttgcctggg ataggggatg aagaaaatac gactgtatcc ccaggattga 1460101 ttgaaatttg gcggtgtgtg ccgtttgcaa ttcttgataa cgccgccatt ggttcccctt 1460161 ggcttcctgt acataaaatt gttactttat tagcaggcat acgattgatt tcgttatgct 1460221 caataaacgt atttttagga cagttaatat aaccgagtgt ctgtccaatt tcgatagccg 1460281 attccatact gcgtccaaat acggcaactt ttcttccatt ttgtacagca gcttcaatta 1460341 cctgctgcaa gcggtgaata ttcgacgcaa atgtggcgaa gataattcgg ccgtccacct 1460401 tgcggaaaat gtcatgaatg ctttctccta cacggcgctc agacatggta aactccggat 1460461 tttcactgtt tgtgctgtct gaaagaaggc acaaaacgcc ttctttaccg atttcggcca 1460521 ttttcgttaa gtttgccggc tcgccgactg gagtaaagtc gaatttgaaa tccccagtat 1460581 gtacgatgtt tccgggcggc gtttttacaa caatgccgta ggaatccgga atactgtgtg 1460641 ttgttctgaa gaatgacaca gccgttttgc ggaactttac aatatcatcc tcgccgataa 1460701 tgttcagttt cgtctgtctc aataatccat gctcttcaag tttattccga agtaagccga 1460761 tcgcgagttt tccgccgtat acaggaatat tcacttgtct gagcaggtat ggaataccgc 1460821 cgatgtggtc ttcgtgcccg tgggtgataa aaagcccttt aattttatct tcgtttttga 1460881 ctaaatacgt ataatcaggg atgacgtagt caattccgag cagttcgtcc tcgggaaact 1460941 tgatccccgc atcaatcagt acaatttcat cctggaattg caccgcgtac gtatttttac 1461001 cgatttcgcc caaacctccg agggcgaaaa cagcagtctg atcatttttt acaaatttca 1461061 taccgctcat aactccaata ctttaaaatt ttcgctctgt tgttcatatt ctaagaatgc 1461121 accatcaaca ggtgtaataa actcaatatt aaatttcttt tctttcagct ttgttctgac 1461181 gtcacgctca gatacgcctt caatataaag tgaatctgtc ttttcccgaa caggtacttc 1461241 gtcagccttc tcttgataaa ataccttata aatcattcca aatctctcct taaatgccgt 1461301 atgttagact cgctcattct attatattcg aaaacggaat ataaggaaag ccttgagcaa 1461361 aataaggatc tctcaaaaag tgaaagatcc cttgtcaggc aattgctttc ttacggagca 1461421 ttccgttcca ttgtcttctg agtttctttc ttaatttacg cagcattagc cagtccctcc 1461481 tttaatgaaa aatttgtccc agagttcttt tatacaaata gtatacggag attgaggaag 1461541 acttttcgtg gttattaatg gaatttaata tgatttttga acgaaattgt ttgctgaatg 1461601 acaatctttt tgtatgatga gggtgggaat tgcagaccaa gacgataaag gggaagttgc 1461661 gatggattct aaattaatct tttttgatat tgacggcaca atatatgatc atgataagaa 1461721 tataccggaa agtacgagaa aaaccgtggc ggagcttcag cgccaagggc atcatgtgtt 1461781 tattgccagc ggccggtctc catttttggt taagccgatt ttggaggagc tgggcatcca 1461841 ctcatttatt tcctacaatg gacagtttgt tgtctttgaa aatcaagtga tttataaaaa 1461901 tccgctgcct gaaaatgcaa tcaggcgatt attaaagcag gcggatgaag gcaagcatcc 1461961 tgttgtgttt atggctgagg acacgatgaa agcgactgtt gcggatcacc cccatgttct 1462021 cgagggaatc ggcagcctta aaacagatta tccagagacc gatgaccttt tttatgaagg 1462081 aaaagaaatt tttcagcttc ttttattttg tcaggatgaa gaagaaaaag cttatgccgc 1462141 ttttcctgag tttgatctag ttcgctggca tgagctatcg actgatgttc tgccgcacgg 1462201 aggttcgaag gcagaaggaa tcaaaaaagt gattgagcgt cttccgtttg atatcggcga 1462261 tacatatgct ttcggcgacg gattaaatga tttgcaaatg attgaatacg ttgggacagg 1462321 cgttgctatg ggaaatgctg ttcccgaact gaaagaaatc gcggactttg taacaaaacc 1462381 ggtggacgag gatggaattg catacgctgt caaagaattg ggccttttaa aataaagaaa 1462441 cggctggcat tgtgccagcc gttttctctt ttagcgctca attgcgattg cattttcagg 1462501 ttctttgaaa ggattttcct tatcaatatg atcatagaac ataacgccgt tcaaatgatc 1462561 gatctcatgc tgaaacacaa tagccggaaa tccttttaaa cgaatatcaa tattttcgcc 1462621 ttctagtgtt gttcctttta ctctgatgcg agcatagcgg ggaacataac cgggaatcgc 1462681 ttcatccaca gagaggcagc cctcgccgct tgttaagtag cttttttcaa ctgaatggct 1462741 gacgatctta ggattaaaca gagcatagct gtataattta ccggaagcat cttccgcatg 1462801 aacggcgatc attcgttttt tgatattaat ttgaggagct gcgagtccta cgccagggcg 1462861 cagcttgtat ttttcggcta attctggatt ttggctgttt ttaacaaatt cgatcatgtc 1462921 ggccagctgc tgtttttctg catcagttgg aggcagctca acaggttcgg cagtctctct 1462981 gagggctgga tggccgtcac gtacgatgtt ttccatagta atcaagaaac ttcactccta 1463041 aagcttaata tgtaaattat atcggatttc ttcacaaagg tgcaacgaaa cgaatgacca 1463101 gccgtatatg gctggtcaat ttcatgctgt gtggttagca acagcctcca cctaaataag 1463161 cagctccgac aatgattaac agaatgaata aaacaacgat tagcgcaaag gtgcggccgt 1463221 agccatatcc gcagccacca tatccgtaac caccataact gcagcagcct ccgccgtaac 1463281 catatccata catattacat aacctcctct tttaattacg ccagagcctt tataagtagg 1463341 catagcgtct aatataacct atgtaaaaac aaaaaagttg tatggtcatc tgtcctgatt 1463401 tttcactttt ttgatttaat ttcagtattg catttataca gcacggctat tgccaaatgt 1463461 ccccatggat tctatagtag aaattgtcaa gattggggga tttaacgtga aagacgctat 1463521 aaaacggcgg cctggaatca agatcggagc tttttgtgcc atggcactga tattaacagg 1463581 atgcatggga caggacccgg ttgattcact tcatcattca ttagaaaaag ccgcggaatc 1463641 ggaaaagccg tttcaagaag aacaaaacac actcaaagaa ttagaggcca aagaaaatca 1463701 gctttacgat agtgttatga agctcaatat ggatgattat aaaaaaattg ttgctttatc 1463761 taataaggcg cttgaaaatg tcagcaagcg cgaagaacac ctaaagcttg aaaatgacag 1463821 catgaaaaaa tcggaaacag aatttgagga agcaaaaacg tcagcggaac atattaagga 1463881 aaaagacata aaagaaaagg ccgatgccgc agcaaaccat atggagaaaa gatatacatc 1463941 atatggcact atgtataaag agtataaaaa agcgcttgag cttaataaaa aactgtatat 1464001 gcagctgaaa gacaaagatt tgacaagaga tgatctggat cagcagatcg ataaagtcaa 1464061 tgcttcttat gaaaagatcc ttaaatatag cggagaattt aatgaacaaa ccgaaaaata 1464121 taataaagcc cgggaagatt tatatgatgc tgcaggctat cgtgtgaaaa agagctgact 1464181 cgatcagctc tttttttgaa tgaaatgcga ttcggatttc gttcaaaatt ttcatttcta 1464241 ttgtagtaca gcatagtaag gtatactagt acagttttgg gtgcggttgg catctgtttt 1464301 tttgatgaaa atgtaaagcg aatacattta ttgaaaatca gcgatgaaaa cgattgacgg 1464361 ttcttcttta tttggtgtaa actaatccat gttaagcggt gttgtattag ttttttacaa 1464421 cttcgaaata atacagttca aagcagagtg taactatcct acataaaagg ttttggcaaa 1464481 ctggggatcg gctaaaatat aatacgactt actgctgata ctttagggta ccctaagttt 1464541 gtatgtataa aaggaatgca cgtctaatga ctgtttaaaa gaaaggaaga ggtgacttag 1464601 tatggctgca aaaacgaaaa aagctatcgt tgacagtaag aagcaatttg atgccattaa 1464661 aaagcagttc gaaacgttcc aaattttaaa tgaaaaggga gaagtcgtga atgaagcggc 1464721 gatgcctgat ttaactgatg atcaattaaa agagctaatg cgccgcatgg tatttacgcg 1464781 tgtgcttgac caacgctcta tctcattaaa ccgtcaagga cgtctcggat tttacgctcc 1464841 tactgcgggt caagaagctt ctcagattgc aacgcatttc gcgcttgaaa aagaagactt 1464901 tgttcttcct ggataccgtg atgtgcctca gttaatttgg cacggccttc cattatatca 1464961 agcgtttctt ttctctcgcg gacatttcag aggaaaccaa atgcctgatg atgtgaatgc 1465021 cctttctcca caaatcatta tcggtgctca atacattcaa actgccggtg ttgcgctagg 1465081 tcttaaaaaa cgcggtaaga aagctgtcgc aatcacttac actggtgacg gcggagcttc 1465141 tcaaggggac ttctacgaag gaattaactt tgccggagct tataaagcac ctgcaatctt 1465201 cgtggtgcaa aacaaccgtt acgcgatttc aactcctgtt gaaaaacaat ctgcagctga 1465261 aacaattgca caaaaagctg tagctgccgg tattgtcggc gtacaagtag acggaatgga 1465321 tccgcttgct gtatacgcag caactgctga agcacgcgag cgcgcaatca acggcgaagg 1465381 tccaacacta attgaaacac ttacattccg ttatggcccg cacacaatgg ctggtgacga 1465441 tcctactaaa tatcgtacaa aagaaatcga aaatgagtgg gaacaaaaag atccgcttgt 1465501 acgtttccgt gcgttccttg aaaacaaagg cttatggtct gaagaagaag aagcaaaagt 1465561 gattgaggat gcgaaagaag aaattaagca agcgatcaaa aaagctgatg ctgaaccgaa 1465621 gcaaaaagta actgatttaa tgaaaatcat gtacgaaaaa atgcctcaca accttgagga 1465681 gcaatttgaa atttatacac agaaggagtc gaagtaagcc atggcgcaaa tgacaatgat 1465741 tcaagcaatc acggatgcgt tacgcacaga actgaaaaat gacgaaaatg tcttagtttt 1465801 cggagaagac gttggtgtaa acggcggcgt attccgtgcg acagaaggat tgcaaaaaga 1465861 attcggtgaa gaccgtgtgt ttgacacgcc acttgctgaa tctggtatcg gcggtcttgc 1465921 ccttggttta ggcttaaacg gcttccgtcc ggtaatggaa atccaattct tcggatttgt 1465981 ttatgaagta atggattcag tttctggcca aatggctcgt atgcgctacc gttctggcgg 1466041 acgctggact tcacctgtaa caattcgttc tccattcggc ggcggtgttc atactcctga 1466101 acttcacgct gacagcttgg aaggtcttgt tgcacaacag cctggtatca aagttgttat 1466161 tccatcaact ccttacgatg ccaaaggact tttaatttct gcgatcagag acaatgatcc 1466221 tgttgtcttc ttagagcata tgaagcttta ccgttctttc cgtcaggaag ttcctgaaga 1466281 agaatacaca attgagcttg gaaaagctga cgtgaaacgt gaaggtactg atctttcaat 1466341 catcacttac ggcgcaatgg ttcatgaatc attaaaagct gctgatgagc ttgaaaaaga 1466401 cggcatttct gctgaagttg tcgaccttcg tacagtaagc ccacttgata tcgatacaat 1466461 tatcgcctct gtagaaaaaa caggacgcgc gattgtcgtt caagaggcac aaaaacaagc 1466521 cggtattgct gcaaacgtag tagcagaaat taatgaccgt gcgatcctga gcttggaagc 1466581 acctgtactt cgcgttgcag cgccagatac agtatttcct ttctctcaag cggagagcgt 1466641 atggcttcca aaccataaag acgttcttga aacagcaaga aaagtgcttg aattttaatc 1466701 aaactgcata atcgagaggg aagatgaacg ttttccctct attatatatc tgttttcaat 1466761 gcttacgatg taaactttaa aattgcttaa tcaaactagg aggtcgagaa ctgtggcatt 1466821 tgaatttaaa cttccagata tcggggaagg tatccacgaa ggcgaaatcg taaaatggtt 1466881 tgtcaagcct aacgacgagg tagacgaaga tgatgtactg gctgaagtcc aaaatgataa 1466941 agcagtagta gaaattcctt cacctgttaa aggaaaagta ttagaattaa aagttgaaga 1467001 gggaacggtt gcaactgttg gacaaacgat tattacgttt gatgcacctg gttacgaaga 1467061 tcttcaattt aaaggcagcg acgagtctga cgatgcgaaa actgaagcac aagttcagtc 1467121 aactgcagaa gctggacaag acgttgcgaa agaagagcaa gctcaagagc ctgcaaaagc 1467181 tactggcgca ggacagcagg atcaagctga agttgacccg aacaaacgcg tgatcgctat 1467241 gccttccgta cgtaaatatg cacgtgaaaa aggtgtagac atccgtaagg ttactggttc 1467301 aggcaacaac ggacgtgttg taaaagaaga tatcgacagc tttgtaaacg gaggagcgca 1467361 agaagctgca ccgcaagaaa cagctgcacc acaagaaaca gctgctaaac cggctgctgc 1467421 accagctcca gagggcgaat tcccagaaac acgcgaaaaa atgagcggta tccgtaaagc 1467481 aattgcaaaa gcgatggtta actctaaaca cactgctcct cacgtaacgt taatggacga 1467541 agtggacgta acaaaccttg ttgcacatcg taaacagttc aaacaggttg ctgctgatca 1467601 aggaatcaag ctgacttact tgccttacgt tgtaaaagct cttacatctg cactgaaaaa 1467661 attccctgtt ttaaacacgt caattgacga taaaacagat gaagtcatcc aaaaacatta 1467721 cttcaacatc ggtatcgctg ctgacactga aaaaggcttg cttgtaccgg ttgtgaaaaa 1467781 tgcagatcgt aaatctgtct ttgaaatttc tgatgaaatc aatggccttg caacaaaagc 1467841 tcgtgaaggc aagcttgctc cagctgaaat gaaaggcgca tcttgcacaa ttacaaacat 1467901 cggttctgcc ggcggacaat ggttcactcc ggttatcaac catccagaag ttgcgattct 1467961 tggtatcgga cgcattgcag aaaaagcgat tgttcgtgat ggcgaaatcg tagcagctcc 1468021 agtcttagct ctttctctca gcttcgacca ccgtatgatc gacggagcaa ctgcgcaaaa 1468081 tgcattaaat cacatcaagc gtttactgaa cgatccacaa ttaattttaa tggaggcgta 1468141 atgttatggt agtaggagat ttccctattg aaacagatac tcttgtaatt ggtgcgggac 1468201 ctggcggcta tgtagctgcc atccgcgctg cacagcttgg acaaaaagta acagtcgttg 1468261 aaaaagcaac tcttggaggc gtttgtctga acgttggatg tatcccttca aaagcgctga 1468321 tcaatgcagg tcaccgttat gagaatgcaa aacattctga tgacatggga atcactgctg 1468381 agaatgtaac agttgatttc acaaaagttc aagaatggaa agcttctgtt gtcaacaagc 1468441 ttactggcgg tgtagcaggt cttcttaaag gcaacaaagt agatgttgta aaaggtgaag 1468501 cttactttgt agacagcaat tcagttcgtg ttatggatga gaactctgct caaacataca 1468561 cgtttaaaaa cgcaatcatt gctactggtt ctcgtcctat cgaattgcca aacttcaaat 1468621 atagtgagcg tgtcctgaat tcaactggcg ctttggctct taaagaaatt cctaaaaagc 1468681 tcgttgttat cggcggcgga tacatcggaa ctgaacttgg aactgcgtat gctaacttcg 1468741 gtactgaact tgttattctt gaaggcggag atgaaattct tcctggcttc gaaaaacaaa 1468801 tgagttctct cgttacacgc agactgaaga aaaaaggcaa cgttgaaatc catacaaacg 1468861 cgatggctaa aggcgttgaa gaaagaccag acggcgtaac agttactttc gaagtaaaag 1468921 gcgaagaaaa aactgttgat gctgattacg tattgattac agtaggacgc cgtccaaaca 1468981 ctgatgagct tggtcttgag caagtcggta tcgaaatgac ggaccgcggt atcgtgaaaa 1469041 ctgacaaaca gtgccgcaca aacgtaccta acatttatgc aatcggtgat atcatcgaag 1469101 gaccgccgct tgctcataaa gcatcttacg aaggtaaaat cgctgcagaa gctatcgctg 1469161 gagagcctgc agaaatcgat taccttggta ttcctgcggt tgttttctct gagcctgaac 1469221 ttgcatcagt tggttacact gaagcacagg cgaaagaaga aggtcttgac attgttgctg 1469281 ctaaattccc atttgcagca aacggccgcg cgctttctct taacgaaaca gacggcttca 1469341 tgaagctgat cactcgtaaa gaggacggtc ttgtgatcgg tgcgcaaatc gccggagcaa 1469401 gtgcttctga tatgatttct gaattaagct tagcgattga aggcggcatg actgctgaag 1469461 atatcgcaat gacaattcac gctcacccaa cattgggcga aatcacaatg gaagctgctg 1469521 aagtggcaat cggaagtccg attcacatcg taaaataatt ttcatatcaa aaacagcccc 1469581 gctttgagcg agggctgttt ttttattttg acagcacatg ctgtaatggt ttaatgatgt 1469641 cttctttctt tttcacacat ccctcgattt tcaccacgac atggcgctga tcaacaacca 1469701 taagggtagg gacagtttca atctcatctt cccagccttc ttttttatca tagaccttca 1469761 ttttatctat ttgctcggga taatcttttt ctaaatcaag cagtgcatcg taataaggcg 1469821 cttcctggtc tatttggttc tcatcagaaa aaaacaggat ttgtgtatga tgaatgttgt 1469881 caatccggct ttttttcatc ggattgatgg tggaaagcgt acagcccgat aaagcaaata 1469941 ctattatcag catggggaat accgcgcgat atcgcatcta tcttctcctc tgtataaaca 1470001 gtagttaact agctttagtt tatcacgaga gacggcttaa tctgcttctt gttacctaat 1470061 tgttatataa ttgaaaccgt ttttaaagtg agattacata ttatatcaat cgtttaaaat 1470121 agcaacctgg ggtatattga attttttgct gcattcttgg atgaaagttc aagaaaacgt 1470181 gcaattacat tatgtgctgt ggcatatata tcgagtaaag cttctgtatg aagaagatat 1470241 tgtatgatgg aaaatggaaa aacaaggtga atatgatgat atgaaataaa atgtgttata 1470301 cagtttgttg ttgacatttt aaatgtgaca tattaatata ataacaacaa aagaaattaa 1470361 gcgttttcaa atttcaaaga aatggggaat aagagatggg tacgattgtt tgccaagatt 1470421 gcaacgaagc cattcattac tttgaagatg agaaagtgac aacattatat ggaacttgct 1470481 gcggacaatg tcaatgtcct gttgatgaag agtaaaaaaa agcatgcggc ttaaagccgc 1470541 atgcttttta ttttttattg aattgctttt tgttctttga tgacccggat catatgtaaa 1470601 gtcgagtcct caggtccttg aacagggagg cctgcgtcaa ggtttttaaa aatgtagctg 1470661 atgttttctt ctgtaataat ttctcctggg atgaagattg gaataccagg cggatatacc 1470721 atgacaaatt cagcaataat ccgtccggat gcttctttta atgggatgac ttccgtattt 1470781 gcatagaaag catcacgcgg agtcattgcc aataaaggta tttctggaag cagaacctca 1470841 gtttgctgat gtgttacatc ttgttctgac atttgctgtg cgatctcagt taaagcctct 1470901 acaagccggt ctgcatcatt ttggctgtca ccaggagtga aaatacacaa aatattgtac 1470961 agatcagaaa gctccacctc aatattaaag gattcacgaa gccatttttc cacgtcatgt 1471021 cctgtcaggc caagactttt cacagagata atcaattttg tcggatcata gctgtaagct 1471081 gctttcgacc caagaatctc agaaccgaca caataaatgc cttcaatctg attgaggcga 1471141 tctctcgtct gattggcaag cttgagtgtt tcctcagcaa gctggcggcc ttctgttgca 1471201 aggcgttttc tggcaacatc caaagaagcg agaagcaagt aagaagttga cgtagttgtc 1471261 agcatgctca ggatggattg cactctgtct ttagatacaa ggccttctct catgtttaaa 1471321 atagagcttt gtgtcagtga tccgcccagc ttgtgtacac ttgtcgctgc tatgtccgct 1471381 cctgcctgca tagccgatag cggcaattcg tcgtgaaaat gaatgtgaac gccgtgtgct 1471441 tcatccacaa gcactggcac atcaaacgaa tgagcgagtt ctacgatgct ttttaagtcg 1471501 gctgcaacac cgaaatatgt cgggttgatg acgagaagcc cttttgcatc cggatgctcg 1471561 gtaagcgccc gtttagcaga ttcaagtgta attccgtggg agatgcccaa ttcattgtca 1471621 atttcaggat gaataaaaat tggaaccgct ccggaaaata caatagctgt cataattgat 1471681 ttatgaacat ttcttggaat aataatttta tcaccaggtc cgcaaacagc cattaccatt 1471741 gtcataatgg cgccgcttgt tccttgaaca gaaaaaaatg tatgatccgc tccaaatgct 1471801 tcagcagcca gatcttgtgc ttgtttaata atgccttttg gcgcgtgcag atcgtctaat 1471861 ggttcaatat taatcaaatc tatgcttaac gcgttttcac cgataaattg tctgaattct 1471921 gggtccattc ctgccccttt tttatggccg ggaatgtgga attgaacagg ctgtctgctt 1471981 gcatgctttt tcagtcctgt gtataagggt gtttcatgtt gcgacaattg ttttcccacc 1472041 tttgtaatca tacctatgca taatagtgtg tattaaaatc agtttctcaa ccgtttttta 1472101 gacgtaaaac aaatgaatta tattatgaac ttgaaagaat gtaaagaaca atttatgatc 1472161 aaatgaagat gctttctctt aagggaagta aatctacaag gagtgaagaa aatggagtat 1472221 caatatccga tgaatgaaga ttggacaacc gaagaagcag tggatgtgat tgcatttttc 1472281 cagcaggttg agcttgcata tgaaaaaggg gcggatcgtg aagaactgct taaagcttac 1472341 cgccgtttca aggaaattgt accggggaag gccgaagaaa aaaagctatg cggcgagttt 1472401 gaggaacaaa gtacatattc tccttatcgc acggtcaaac aggcgagaga atctgatcac 1472461 gcgaagatta agatgtaaga aaaagagccg ggggatatcc cggctctttt ttatgcttgt 1472521 gttacttttt gggtgagacg gtacagaaaa gcaagctgtt taaaggcatc gtcgatacgc 1472581 tgaaggaatt cctggttatt catattcagc acttcttctt tttggagctg gatgccgcat 1472641 aacagctcgg ctttctttac agtctgcaaa cgctcaaaca gtgtcttcag ctgttccttg 1472701 tccatttcag actgtttatg tactcccggt tttgtgtgat ctgcagacca aacgaagctg 1472761 tcagggatat ttttcgtaat ggtttcttgg ttcacttcaa gcaatttgcc gtattcttct 1472821 ttgatagggg attcataaat aatcgcgaac catacaaaga cgtggctttc ccataaacca 1472881 atttggaaat gcggcagttt tttatagcct cttttgctgt ttgcgaacgc cacccagctg 1472941 tcagccgggg gattgacgga tcttcttgcg tgctttgcca catgcggaaa catttcatct 1473001 ccggttaaag ctgataaagt tggggcaaaa tgttcgccta gagctgtaag cttcggacgg 1473061 accgtctctt ttaatacttc catgcgcgcg tctaagcctt ctattgtaaa tgtgttaaag 1473121 tcttcttcag tgaaacgcat ttgtgtcatg attttcctcc ttcatgctaa gtatacatat 1473181 tttatcacag ttcatacgag cttcaaaaag attgagcgcg tttgaagtaa ggagaaatgt 1473241 ggtaataaac gagtaggtaa acacacaatt ttcagaatca tgttgcgcgt aaatagaaca 1473301 atcatacgat ataagaagta atcattgttg aatggcaaaa tgggatgctt ttttacaaac 1473361 aaatgatctc tggaaggggc gaaagacaat gaggcaagtt gtaaaagagg gatttaagga 1473421 agagaaaaac aatcgtgttg ctgtctggag actagaggtt gattatgaat tggcaaccct 1473481 atatgaagca atgcagaaag aaaatgaaga gcagattgaa caaagcaaaa acaaacttga 1473541 gcgacttaga aaagaatgga ttcgtcttaa cgggtaaaaa agcgatagtg aaaacgaacc 1473601 gcatgaatgg ttcgttttta cgtgagaagg gatatttttc attttccttg ctttttcatt 1473661 gccgttatca gtatcctata aaataaaagg tctacataga agagaggtac gaacgaatga 1473721 caaattggac ggaaatcgat gagattgcaa agaaatggat aagagaagca ggcgcgagaa 1473781 ttacacaatc catgcatgaa agcctgacaa ttgaaacgaa atcaaatccg aatgatttag 1473841 tcaccaatat tgacaaagaa accgaaaagt ttttcattga tcgaattcaa gaaacatttc 1473901 cgggacatcg gatactcggt gaagaggggc aaggagacaa aatccactca cttgagggag 1473961 tcgtatggat tattgatccg attgatggga cgatgaattt tgtgcaccag caaagaaatt 1474021 ttgcgatttc cattgggatt tttgaaaacg gtgaaggtaa aatcggttta atttatgatg 1474081 tggtgcacga tgagttgtat cacgcattta gcggcagagg agcttatatg aatgaaacga 1474141 agctggctcc attaaaagaa accgtcattg aagaagcgat tcttgccatt aatgcaacat 1474201 gggtaacgga aaacagaaga attgatcaaa gtgtgttagc gccacttgtg aaaagagtca 1474261 gaggcacacg ctcctacggt tctgccgctt tagagctggc aaatgtcgcg gcaggaagaa 1474321 tagatgctta catcacgatg cggcttgcgc catgggacta cgcagccggc tgtgtgctgt 1474381 taaatgaagt aggaggcacc tatacgacca ttgaaggaga gccgtttacc tttttagaaa 1474441 accacagtgt gctagccgga aacccatcta tacataaaac gatatttgaa gagtatcttc 1474501 atgctcggaa gtaggccatt tgagcaggat gatctcagct tgttagaaaa gctcgcggag 1474561 gctcatcctg tatggaaaga ggaggagttt ggagataaag atgcagaaga ctatatcatt 1474621 tcctactcca tgtacaacgg ttcatggctt gtatgggaaa aagacggtat gcctgttgcc 1474681 gtcagctacc atctcgagtg gtctccttca aacggtaagc cgtggctcgg aacggtcctg 1474741 attgacccgg ctgaagaaaa aaagggacat gcgaagatga tcattgaaca gatcagcaaa 1474801 ttgcttagag cgaaacataa agcgatgttt gcgggagttc ccattgagcg cagggaatgg 1474861 atactgtttt taagccaatg cggctttgaa cagctgaaaa cggaaaaaga tgagaaaggc 1474921 aaatcattta tgatcttggt gaagccttta gcagaagctg ccgtatgata atggcagctt 1474981 atttgctgca tgcgggttca ataaaaagcc tctcaaacat tgagaggctt ctgatgattt 1475041 gaaaattatt tttttaccgc atgaatataa tgaatcgttt caaacgctga caaattgtct 1475101 tttcgattac taaagaaaag gtcattgatg tcgtctggtg atagatgttc atagatcagt 1475161 aaaccagatg actctaacag atgttcaatc tcttgataag tgaaacatga tttcatcggt 1475221 tccccgcttg cggcagccat cttcaccata tgttcaactc gattcgacgt cccttttgct 1475281 gtaaaaagtg tttcgtccgc ataatcaaaa acaatagagc ttccaggcgg gacatgagaa 1475341 aataaattgc tgatcaagct tgcattttct tcccgtgtta cataataaga cactccgaga 1475401 aggctgaaga atgtttttgt gtttttaaat ccttcatcta agagaggatc atacgaaaac 1475461 gttttggtga aatccatagg aacaaaatga agatgacccg gaattgtcag atttgcatcc 1475521 ttcagcttat tttttttcaa ttgctgtgtg gccggatgat caacctcgaa aacctgtaag 1475581 ctgttttcta attctggatg ccgaaagcag aaagtatcca gtcccgctcc aagaatgaca 1475641 tactgttttg cccccaggat taattcgttg tgcaagactt tttcacaata agaagcacgt 1475701 gctaggggcg ttggagacag ctggatttgt gcaacccatt ttaatatttt ttcaggatca 1475761 ttttgaagac gttcggcgat ctctttgttg aaaaacgata tttcttgaat catattttta 1475821 ctgatgtcga taaactcttt ttcgttaatg agatcttttg cgataaaatc atcaaaaata 1475881 agaggtgtgt catatcggct gtgatatgca cgggcaaaag ctgaaattag agacgttaag 1475941 ctggactcat ttttcctcat gaaatgatcc tccacaaaaa ataagattcc cctggccagg 1476001 agaatcttat tatacataca aatatattaa tagtaaattt tagcataaat aaattttttt 1476061 gtcaatgttt ttgctcttaa ctggacgcgc gatccttcac atagccacgt gacctgtagc 1476121 agaattcgtc tatcaattat gtggactgaa tcattagctt ttataaaatg cgcacttgcg 1476181 gctgcatccc tctttatgca aatcaggagc ggttttctgt ctcatggcag catcttttcg 1476241 tcgtttcagc tgagagagaa atcaagatat gtaacaataa aagcctgagg gatctcaggc 1476301 ttttcctaat attacaatcc aacagcattc caggctgctt caactttagc ggcatcagtt 1476361 gagccgtaga ggtcacgggc agactgaatg agagctgcct tggcatcttt gaacgtggaa 1476421 gaaggcgtga ggtacgttgt taacgcacgg taatagattt gctgtgattt agatacacca 1476481 agttttgtga tggtgttgta agcggctttg tttggaattc cgctgtttgt gtgtacaccg 1476541 ccataatcgc cttcatctgt gtttggaagg tttcggtaat tggcgtaatt gtcaggctgg 1476601 ttgtattttg tagggttgga caggctgcga agagcaggct ggctgaccgt aatgtcttca 1476661 ccgatgtccc agtcttctgt atcgttaaaa tacccgaata cgtcagagaa agactcgttt 1476721 aatgcacctg gctgattttc ataaatcaag ttggctgttt cttgggtgac gccatgtgtc 1476781 atttcatgcg ctgtcacatc taatgagccg gaaagcggag agaagaatga accgtcgcca 1476841 tcaccgtaaa tcatctggtc tcctgtccat gcagcgttat tgtattgagt gccgtagtga 1476901 acggaagaaa cgattttact gcctttgtta tcatagctgt ttcgtttaaa gtttgaataa 1476961 aaataatcgt acactttacc gaggttatag tgtgcgtcaa cggctgcccg ctgtgatgaa 1477021 gatgtaaatg ttttcgttgt gcttgagaca agcgtgcccg gaaggcggct ttgtctgttt 1477081 tgcaaatcat atgtgatgat ttgggtgcct gttggttttg aaagatctct tagaacatat 1477141 tttccgcctt cataagagat gttcaaagga acagttgcgc cctttagcgt tgttccgctt 1477201 ccagtggcgg cggcatgttc tactttattt tgctgtttta aaatgctgcc tgtttcggcg 1477261 tcaactaaga cttcccagtt tgcaggttca ggctcgacat agcgaatcgt cacgtcgtaa 1477321 gcaagacgat agctgccgtc ttttgtttct atcgctttta attcggcttt attgctgttt 1477381 ttggccgctc cgttagaaac agcgtctggt gatttgccga tagctttgaa agcgagtgcc 1477441 agcgcttttt cagaagagac tttttggctg ttatctgttt ttgcagcaga ttgattgtgt 1477501 aattcaccat tgaccgcata gacattatcg gatttatcga cgtgaacgat cacttgcgaa 1477561 tctttaattg gcactccgtt aacgacaggc gcatatcgaa agtgcttgta tccaagggca 1477621 tcagtcgtgc tttcaacaag cttcagcctt ttggaagggt cacctttaaa aatgttgctg 1477681 ttctttttca aaaactgctt gacagccttg tcatttggtg cagagagttc tgattgcgca 1477741 atcgcgtttt tggagaggaa atttgtttga ttctctttaa gctgatgacc ttcagcagcc 1477801 tgaacacctg gcaggctgat tgataaactc ataaacgaag cagcgacagc aacagacaat 1477861 ttcttaccta aacccacaat aaatccccct ttttgaaaat actgaaaact ttatattgtt 1477921 atattaaact agcattctgg aatactcaac aaaaactaac ataactagac aaaattgata 1477981 gtattgtcct gtgtttgttt ttgttgaata atatcaagat gagtcaagtg tcatgtggtg 1478041 gttcattcaa gagttatgtt ttttacatat caaggggaag atgagatatt tttgtttcat 1478101 cttgaaactt tttgaaaagt ccgctgtcta accgaatgag gccttaataa gaagtaaagg 1478161 attgttgttc gtgttggagt tattcagtca ttatgtattg catttcgaac gttattttat 1478221 attaagcaga caaagcaccc tgctgattca atggtcaatt gttgttctgg cgggcttata 1478281 tcttttggtg catcatccca aaataaaccg gcagcgcaca atgttcttgg cgggtgttat 1478341 attgcggatt gtgctgctgg cgggagtgtc tgttgaactt attcaccagg tgcaatcaac 1478401 aaacttcacc agcgcttact taagagagga cggaaaagaa ctgctgccgc tgctgcattt 1478461 tttgttatac ggatatgtgc tgctgacggc ttttcactat atgctgatgc cgcgtgatca 1478521 tggcggaaag ggtaagtttt atacgttcga ccttgctgtt gtcagtttgc cgatcgtaca 1478581 aatgattttt agtttctttt cgtattggaa ggaatacccg gatgggatgg agccgattgc 1478641 attcgtgttt ctgtttttca tcatcactct tcccattgcg ttgaatgtag tgtttttcaa 1478701 gctgtattgg agaacggata agatcttact aggcttattt tatacgctga ttatcggact 1478761 gcttgtcttg ctgcttgcgc catatcccaa tcaaatctca aaagattatg gtgcagtaat 1478821 gccatatacg atttatttgg caatggcggg atttttgatg agctatcatc tgttccaaaa 1478881 gtcaggaaag gtttatgtgc gtgtgaataa gtgggtgacg atggctgtca tggtgttttt 1478941 tgtcctgctg ttaaatccga tatataacat aggaacggct gctttcgctg tatcaaagcc 1479001 agcaaatgtc catgattcat tcaattttgt cggggagcac atttcatcag aaaaagcgga 1479061 acagatacta aagtcatttt ttcctacgga tgaaacactt tatttgcacg atacaaacat 1479121 ggatgtgcat tatttctact catttgaaag caaaggttac aaagctgagg tagatgaagt 1479181 atcgcagcta attcgtaatt atgaatactt acaaaaagca catgggaaaa agctaacgaa 1479241 tcaggagtac aagcgaaagt ccatcgcttt ccttgagcga cacggacgtg tgttacataa 1479301 ggatcatatc gaaacaaagg tatctcaaga agacggccag acagtcgtac gtatttacct 1479361 gaaaaatcaa cttcataaaa aagatcatgc tgatgatggc gcggtatttt attgggaaaa 1479421 ggaaacctta atggggttta gtgaagatcc ttcgatttat cagcttgact ctcttctgca 1479481 tgttcatata acggaacaag acattcacga caaagtggaa caaatgttta cagcgctgaa 1479541 catatcaaaa cagccttatc agatcactga tattgaaagc gacagcctgc ttggaagcat 1479601 ggtgagagtt gaaacaaaag ttggaattgt tttggaattt gagggcgaat caggttgttt 1479661 acatagtctt tcgcttccga tgaaaaagaa tatctcaatg gctaacagcc ggctgcagca 1479721 tcagatatta tcgatcttcg atgctcgtgg atcagaaaag aagaaaaaaa gcagtcaggg 1479781 tgacatggtg atgtatactg attcttctaa aacatatgag tttgttgaag ctcaaggtca 1479841 gctaaacgtt tatgtataca gcgatacacc tgatcagtca ttcccctata cgtatcgtaa 1479901 tggaacattg gcttacgaaa aagtagcttc tctatatcag gatgtcattt acaaaaagcg 1479961 tatgcgtccg attatcgttc aaagagggga tgaacggcat tatgcatggc tgatcattat 1480021 tcagccgttt ggttcaaatc gccatgatgc ctatgtagtg gatggagaaa cacaagaggt 1480081 gaaaagtctt tatgaatcat aaagaaaaag agtctgtttt tgtagactta tacgacctgt 1480141 ataaagaagg agagctagag gatgaatcaa tggaatggat gaaacagcat gaatccctat 1480201 ttcaaaagaa tgcggaagac ttaaagagta aaacttgttt aaagagaagt cccggtgctg 1480261 aagaagaaag ccaaatcaga tatatgaaag tatacctgtc ttccatgtat atctgtttca 1480321 ttttattggc catttggatg acggtgtggt tttattttta atgaagcata gggattccat 1480381 tgaggacttg tatcggcagt attatcaaga aattttaaat tatttattca gaaggactca 1480441 tcatcttgaa acagccaagg acttagcgca ggacacgttt gtaaaagctc ttaacggtct 1480501 ggcttcgttt agggggcatt cttccatcag aacatggctc tacaccattg cgcatcatac 1480561 ctttatcaat tggtaccgaa gggatgtcaa ataccaattt actgaaatca gcaaaaatga 1480621 agggttaacg caaacaactt atgaccagcc tgaacagtat ctgtcacgga cggtgaaaag 1480681 cgaaacactg cggcaggagc tcctgaagtt aaaagatcag catcaatccg ttttgatttt 1480741 aagagaattc caagagcttt cttatgaaga aatcgctgag atattaggat ggagtctttc 1480801 taaggtgaat accacattgc accgggctag attagagcta aagaaaaaca tgacgaaaag 1480861 tagagaggag gagcggatat gacctgcttt ctagtaagag acctgcttcc tctgtatctt 1480921 gaaggtgatt gtaaaagaga aacggaacac gttatagaag agcatttaaa aatgtgcagc 1480981 agctgcagag acatgtatga cacgatggct gagccatttg aattggaaag cgaacaggcc 1481041 gttgaggagg cttatctgcc ggaagaagaa ctgcgtttta aacagaggta ctatggatta 1481101 ctgatcatga aagctgcctg ctggtttgga gcggcggttg ccatgatgct gatcatcaaa 1481161 ctgctgatat aaaaaaagcg cttgtccgat tccggcaagc gcttttttac attaagcctg 1481221 gggatgaatc atatcgtaaa tagcggcaag ctgttcttgt gacagggcac tgaagagttt 1481281 ttcataaacg tcagcttgca gtggcgttgc acctgcttgt agcgctgcgt ctttatcata 1481341 gctgtacaca tcatcttgta gcacaatggc tgcttgaaga atgtgaatct tgagagaaac 1481401 agcggagaaa aattgttcaa gtgcaagtgc ttctttttct gtgaagccaa gttcaactgc 1481461 tttttctgta tcaaatttgt aatttccatc ctcgagatac acacattgtg aaacaatgct 1481521 gaaaaattct gatgtcgatt cccagagtgt agcaattacc tgagcctctt cttttgtcat 1481581 tcctaactcg acagcttttt cgctgtcaaa ataatataca ccgtcttgtt cgtatataca 1481641 ttgatttaat atatcaatga atgtattgag atcttcgtta gtgctcgcct gatgctggag 1481701 ttgaacagca gtgttatcaa ccggtgtttt tgcgctggct gcatcaggac cgaacgttaa 1481761 tagagcagct gaggtcattg cggcagtcgt taacatagct ttttttacaa atgttttctt 1481821 catgtttctt ctctcccttt tatgaattgt gctacaaatt ccattatagg gagtagtttc 1481881 cggtggagga ataggcgcta tggtatttta tgtgtatcgt tgccgaacta ctttttgaag 1481941 gctgcacgtg tgatcgttag aacgattgtc tatgtatgaa ggctgttttg catcttcctg 1482001 actaagaaac aggggagata aggcttaaag aaatgaaaaa caccgctttc tttgcggtgt 1482061 tttttgatta caatgtcgcc ggcggggcaa tgcttttaat caagcaagcc ttgttcgcgc 1482121 attttctttt ttaatgtaaa tccgccgccc atgacagcgc aaacaagtac aatgctggcg 1482181 ataatgcctg cagggctttt ttcagcgata aagacgccga tcagcataat gctgaaaacc 1482241 gctgcaaatg caaataatag taaaagccaa ttcatttttt tcataaattc catccccttt 1482301 tacgtcttat attaagttta cagaaaaacg tgacgctttt aaagaggatg tgtgatataa 1482361 tatgaaagtt atctaatttt tttaggagat gaaaaagtga aacttcgaaa tgatcttcgc 1482421 aacatcgcga ttattgccca cgttgaccat gggaaaacga ctctagtcga tcagctttta 1482481 catcaggctg gtacgttccg tgccaacgaa caggttgctg aacgcgcaat ggactctaat 1482541 gatcttgaac gcgaacgcgg cattacaata ttggcgaaaa atactgcgat taactataaa 1482601 gatacacgta tcaatatttt ggacacccct ggacatgcag actttggggg agaagtagaa 1482661 cggattatga aaatggttga cggcgtagtg cttgtcgttg acgcatatga aggctgtatg 1482721 cctcaaactc gttttgttct gaaaaaagct cttgagcaaa acctgaaccc tgttgttgtt 1482781 gtaaacaaaa ttgaccgtga ctttgctcgt ccagaggaag ttatcgatga agttctggat 1482841 ctgttcattg agcttgatgc caatgaagag cagctcgagt tcccagtggt atatgcttcc 1482901 gcgattaatg gaacagcgag tcttgatccg aaacaacagg atgaaaacat ggaagcttta 1482961 tatgaaacca ttattaagca tgttccggca cctgttgata atgcagagga gccgcttcaa 1483021 ttccaagttg cccttcttga ctacaacgac tatgtaggcc gtatcggaat cggacgcgta 1483081 ttccgcggca caatgaaagt cggacagcag gtttctctta tgaagcttga cggaacggca 1483141 aagtcattcc gtgttacaaa gatttttggt ttccaaggct taaagcgtgt ggaaattgaa 1483201 gaagcaaaag cgggagacct cgttgcggtt tccgggatgg aagatatcaa cgttggtgaa 1483261 acggtatgtc ctgtagacca tcaagatccg cttccggtcc ttcgcattga tgagccgaca 1483321 cttcaaatga catttgtcgt gaataacagt ccgtttgcag gccgtgaagg caaatatgta 1483381 acggcccgca aaatcgaaga gcgtcttcaa tcacagcttc agacggatgt gagcttgcgt 1483441 gttgagccaa cagcttctcc tgatgcttgg gttgtttcag gacgcggtga gctgcacttg 1483501 tcaattttaa ttgaaaatat gcgtcgtgag ggctatgagc ttcaagtgtc aaaacctgaa 1483561 gttattatca aagaaatcga cggcgtacgc tgtgagcctg ttgaacgtgt gcaaattgat 1483621 gttcctgaag agcatactgg ctctgtaatg gaatcaatgg gtgcccgcaa aggcgaaatg 1483681 gttgatatga tcaacaacgg aaacggccaa gtccgtctca tctttacagt tccttcccgc 1483741 ggattgatcg gttactctac agaattccta tcattaacac gcggattcgg tattttgaac 1483801 catacgtttg acagctacca gccgatgcag gcaggccaag tcggcggacg ccgtcaaggt 1483861 gtacttgtgt caatggaaaa cggaaaagca acatcatacg gtattcaagg aattgaagac 1483921 cgcggtgtca tcttcgttga gccgggtact gaagtatacg aaggaatgat cgttggagag 1483981 cataaccgtg acaacgacct tgttgttaac gtcagcaaaa tgaaacagca aacaaacgtc 1484041 cgttctgcga caaaggatca gacaactaca attaaaaaag cgcgcatcat gtctcttgag 1484101 gagtctctag agtacttaaa cgaagatgaa tattgtgaag taacacctga atccatccgt 1484161 ttaagaaaga agatcctcaa taagaacgaa cgtgaaaaag cagctaaaaa gaaaaaaaca 1484221 gcaggattgt cttaatctcg tgcagaattt gaaaagatag aacccgtacg tttacagggg 1484281 agggaatctt tttgaatgac gtaagcgaac gcctgtcgtt cttcgccgct ctatatcaag 1484341 tagaccggca gcctgcggca ggcatgtggc tgctgtacgg cacgattttt gtgttggccg 1484401 ttattgtatt taagcttgga tttgctaaac ggcttcctgt attaaaatct gcagtggtgt 1484461 atgtattttt ggctttgggc tgcactgttt tgactttttt aggggtgttt ttgcccgtgg 1484521 cagaaggatt ggtcgtcgct gcgctgattt taatcattta caaaatccgg ctgtatcagt 1484581 cgaaaaaagg acagtctgca aaatcataaa agactcagct gaaagctgag tcttttttgt 1484641 gttctgtatg gttaagcggc cgctttattt tttgactttt tcttttttct gctgtcccgg 1484701 gtgaaaagta aattttcccg ttttcagccg ttcctctgtt tttttggcaa tccgatcgtg 1484761 gcattcctgg cacatatatg tatggatcgg gcggtttcga agccgtttcg cgatcagggt 1484821 atcatcatca attgtttcaa ttttatcgca aatagaacat ttgaccctca tcatatcacc 1484881 tctttcacta acatgtatta taccacggat cagaagctgt ccaaaataag aaaaagctaa 1484941 agcgcaaggc tatagcttag tcattgttgt tctttttcat atgatgatca gattgatcgt 1485001 tttgttcctt ctccatttcc tgttgctgtt ttctatttaa ttggtcattt tgctgctttg 1485061 tttgcggttc atcttcattg tcaatcacat cgttaggcac ttcgggaagc actcggccga 1485121 caattgcagc taattcatcc agtatacctg ttaccggatg gccctcgctg atttctctgc 1485181 tcatttcgcg aaggcggctg accgtatcgg gatcagcaat gactactgcg ttggcgccat 1485241 atcgatcatt ctttagcgcc tgagctacag aatatttaat ggtttccact ttgcttctgt 1485301 ccaaagtatc atcgacatca atcccaacaa cagcatagcc tcccagcaca acggctgttg 1485361 catccttgac gtcggggttt ttttcagcaa cgctgacaag atgcttggca atatccgttc 1485421 ttgttccatt gtcttttgtt tcttgagttg tgtcctttac gtgaatcggt ttagtctcct 1485481 gctgtcttgt tgattctttt tcaacattct ggccctgttt tccttgttga taggcacaag 1485541 cggacaggat aagtgtcagc tgtatgataa tgaaaagaat tcgcacttgc gggttccctc 1485601 cttaaaatgc tttcattaat tttattgttg aattaacctt ctatctttat gcacaaaaac 1485661 atatatttta gcaggcattc acctttttca tcaaaagaga agcaggaaga actttgaccc 1485721 ttatatcagg aggctgagac ttgagtaaaa tttatgtgtt agatacgaat gtgttattac 1485781 aggatcctaa cgcgatattt tcttttgaag aaaatgaggt tgtcatccct gctgtcgttt 1485841 tagaagaggt tgattcaaaa aaacggtata tggacgaagt tgggaggaat gcaaggcacg 1485901 tatctaagct aatcgatgcg ctaagacaaa agggcaggct gcatgagcat gtaccgcttg 1485961 acaccggcgg cacactgaga attgaactga atcatcgttc gtttcaccag ctgcaagaga 1486021 tctttattga aaagacgaac gataatcgca tattagccgt tgcgaaaaac ttaagcctcg 1486081 aggaagaaac caaggaaaat ggcaggccgg ttatccttgt cagtaaggat gtactggtca 1486141 gggttaaagc cgacgcaatc ggactgcttg ctgaagattt cttgaatgac cgggttgtgg 1486201 acaatgatga aatgtacagc ggctataaag atttatatat cagccagcag ctgttcagct 1486261 ctttttacgg gaaaaatcaa atttcagtaa acgatgtgaa acagcatgcg ttttatccga 1486321 atcagtttgc tttaatgaag gatgagctag gagggtcctc ctcggcagtc ggaattgcag 1486381 acaaaaccgg aacggtatta aaaagactcg tatttgatga tgaacatata tggggaatca 1486441 ggccgaaaaa tgtacagcag acaatggcat tagagctttt gctgcgggaa gatattccgc 1486501 ttgtcaccct gatcggcaaa gcgggaaccg gcaaaacgct cttagctttg gcggcagggc 1486561 tattacagac agaagacttg ggaatatata aaaagctggt cgtcgcaagg ccgattgttc 1486621 ctgttggcaa ggacatcggg tatttgccag gcgaaaaaga ggaaaagcta aagccttgga 1486681 tgcagccgat ttttgacaac ttagagtttc tgtttaatgc gaaaaaacca ggggagcttg 1486741 atgctatttt ggcgggaatt ggctcaattc aggtagaggc gctgacttat atcagaggga 1486801 gaagcattcc agatcaattt attatcattg atgaagcgca aaatttgacc aggcatgagg 1486861 tgaaaacgtt gctgacgaga gtcggtgagg gcagtaaaat tgtcttaatg ggcgaccctg 1486921 aacaaattga tcacccatat ttagacagtc tgaacaatgg tttggcctat gtggttgagc 1486981 ggtttaaagg acaacccatc tcaggcagcg tgaagctgtt aaaaggtgag agatcaggtc 1487041 tcgcccagct tgcagctgat ttgctgtaac acttaaatga tttcgatctc ttttacatcg 1487101 gtaatcggct gtttgtgatg aaccgggtct tcaaagtaaa tatgcacggg gccgccttct 1487161 tgaatcggct tgcctgcctc actgaaatgg acaatactgt tcagagcggt ttccagagaa 1487221 acggcggcct ttcccgaact tgtgacaaat acacattgtg tcgcagagct gttcggctca 1487281 gcatttttca ggacagtccc aagtctcatt gcgaaactgc cgttcatcag tttttgcttc 1487341 tcatattgct tttccgtctt taatgtaggc ggcgcgattc gcccctctct gatgacgcgt 1487401 tccggatcaa ggtcggattc atccccggct gattgtaaat atgtgtcttg actgtcccct 1487461 ttgcggtcaa acgaaaattt gcgatcatca aaaatccata cgcttggatc aatggtaatt 1487521 ggatatgtaa cattgccttt tacttggata acgctcatga tatgaccccc ttctctcaaa 1487581 attataaaag ttttcgcatg aattgtcact ttgtgtacaa attatgtgta ttgaaatgct 1487641 gagggaacga gggtgtttgc atggtatgcc agcataatga tgagcttgaa gccttagtga 1487701 aaaaggcgaa aaaagtaacg gacaaggggg aggtagccag ctatattccc gccttggcaa 1487761 aagctgataa acacgacctg tcagtggcga tttattattc caataatgtt tgtctgtcag 1487821 caggtgacgt agaaaaaaca tttacgcttc aaagtatatc gaaagtcctt tcccttgctt 1487881 tggtgttaat ggaatacggc aaagataagg tcttcagtta tgttggacag gagccgaccg 1487941 gtgatccgtt taattcaatt atcaagctcg aaacagtgaa tccgagcaag ccgttaaacc 1488001 ctatgattaa tgccggggca ttggtagtga caagtctgat aaggggaaga acggtaaaag 1488061 agagacttga ttatttgctt tcttttatca gaaggctgac aaacaaccaa gagattacat 1488121 actgccggga agtggctgaa tctgaataca gcacttcaat gattaatcgg gcgatgtgtt 1488181 attatatgaa gcagtacggc atttttgaag atgatgtaga ggcagtaatg gatttatata 1488241 cgaagcaatg cgcgattgag atgaacagct tggatttagc gaaaatcgga tctgtattcg 1488301 cattgaacgg cagacatcca gagactgggg agcaggtcat ctcaaaagat gtcgctagaa 1488361 tttgcaaaac gtttatggtg acgtgcggaa tgtacaatgc aagcggggaa ttcgcaatta 1488421 aggtcggaat tcctgcgaaa agcggcgtat ccggcgggat aatgggcatt tcgccttacg 1488481 atttcgggat cggcatattc ggccccgcat tagacgaaaa agggaacagc attgcaggtg 1488541 taaagctttt ggaaataatg tctgagatgt acaggctgag tattttttaa tttatgtcat 1488601 atgcttaaat cctcttgcat tttctgttga taccctttat gataaataga agaattaggt 1488661 actcgcctgg ggaacggagg gatacttttg gcttcagaga tgatagttga ccatcggcaa 1488721 aaagcttttg aactcttaaa agtggacgct gagaagattt tgaagctgat ccgagtacaa 1488781 atggataact taacgatgcc tcaatgtcct ctatatgaag aggttttaga tactcaaatg 1488841 ttcgggcttt cgagggaaat cgattttgct gtccgcctgg gattggttga tgaaaaagac 1488901 ggtaaagacc ttttatacac attggagcgc gaattgtctg ctttgcatga cgcgtttaca 1488961 gctaaataaa tgataaaact caaacttatt aacagtttgg gtttttttat aaccgctatt 1489021 tttctctcat ctcataaaag acggtctttt tttacacatt ccttccgaat cgtatagaga 1489081 ttcttcgtct cgtttgataa attgtagtaa aataaaaaag ataaatacat aaaaaccata 1489141 gataatggaa gttagaagca gggaagagga tgttatgtta aaaaaaatgc taaaatctta 1489201 tgattactca ctgatattcg caatcgtttt attatgcgga ttcggtttag tgatggtata 1489261 cagctcaagc atgattacgg ctgtctcccg gtatggagta agcagtaatt ttttcttcat 1489321 gcggcagctg tttgctttaa ttgcgggtgg cgctctattt attctcatgg cgttgtttcc 1489381 ttataaagca ctggcccatc aaaagtttca gaaggggata ctgcttgtat ctgttcttgc 1489441 gcttatctca ctgtttgttt tcgggcatgt tgccggaaac gcgcagagct ggtttaaaat 1489501 cggcggaatg agtattcagc cgggggagtt tgtgaaactg gtcgtgattt tataccttgc 1489561 agccgtatat gcaaaaaaac aaagttatat cgaccatctg ttaacgggag tagcccctcc 1489621 ggtagtcatg acgcttataa tttgtgggtt aattgccatg cagccagatt tcggtacagc 1489681 catgattata gggttaattg cgacgtgcat gatcttgtgc tccggcttca gcggaaagac 1489741 gctggtgagg cttgtgatac tgggcggaat tgttttcatt ttagtcagcc ctattatcta 1489801 tttgaatcag gacaaaattt taactgaagg ccgtttagcg cgttttgaga gtcttgaaga 1489861 cccatttaag tatgcaaatt catcaggttt gcaagtgatc aattcttatt atgcgatcag 1489921 ctcaggcggc attttcggcc tggggctcgg tgaaagtatc caaaaatacg gatatctgcc 1489981 tgaatcacac actgacttta ttatggctgt cattgctgaa gagctcggca tttttggggt 1490041 attgtttgtg attttcttat tgggttttgt cgtcataaaa ggtttttata ttgccagaaa 1490101 atgcgaggac ccgtttggaa gtcttctggc gatcggcatt tcaagcatga ttgccatcca 1490161 gtcgtttatt aaccttggcg gtgtcagcgg attaattccg attacagggg ttacgctgcc 1490221 atttatcagt tacgggggct cttctttggt gctgctgctg gggagtatgg ggatattagc 1490281 gaatatcagc atgtttgtga aatattcaga gaataagaaa aagaaagagc ccttggcgcc 1490341 gaagggaatg aaaaagaaac agctcaaaaa aactgtttat ctgtaaaaaa caagtgtgta 1490401 caggggaagg atattccgct atgatagatt atattccatt cgggtaaggg ggagaaaagt 1490461 ttgtctcagc aatcgataca aaaagtatta gtagcaaaca ggggagaaat tgcaatccga 1490521 atattccggg cgtgtaccga gttgaatatt cgtacagttg cggtctattc aaaagaagat 1490581 tccggttcct accatcggta caaagcggat gaagcatact tggtcggtga agggaaaaaa 1490641 ccgattgatg cttacctgga tattgaaggt atcattgata ttgcgaaaag aaacaaagtc 1490701 gatgcaattc atccgggata cggtttctta tctgaaaata ttcattttgc gagacgatgt 1490761 gaagaagaag gcatcgtatt catagggcca aaatccgagc atctcgatat gtttggtgac 1490821 aaggtaaaag cgcgtgagca ggcagaaaaa gcgggaatcc ccgtgattcc gggaagcgac 1490881 ggtcctgccg aaacgcttga agccgtcgaa caatttggac aagctaacgg ttatccgatc 1490941 atcattaaag cctcgcttgg cggcggcggc cgcggtatgc ggattgtcag atctgaaagt 1491001 gaagttaaag aagcatatga gcgtgctaaa tcagaggcga aagcagcctt tggcaatgat 1491061 gaagtttatg tagaaaaatt aattgagaat ccgaaacata ttgaggttca ggtcattgga 1491121 gacaagcagg gcaatgtcgt ccatcttttt gagagggatt gctccgttca aagacgccat 1491181 caaaaagtca ttgaagtggc gccgagtgtc tcgctgtcac ctgaattaag ggaccaaatt 1491241 tgtgaggctg cagttgcgct tgccaaaaat gtaaactata taaatgcggg gacggtcgaa 1491301 ttccttgttg caaacaacga gttctacttt attgaagtaa atcctcgcgt acaagttgaa 1491361 cacacgataa cagaaatgat tactggtgtc gatattgttc aaactcagat ccttgttgcc 1491421 caagggcaca gccttcacag caaaaaagta aatattcctg agcaaaagga catttttaca 1491481 atcggctatg ccattcagtc acgggttacg actgaggatc cgcaaaatga tttcatgcct 1491541 gatacaggaa aaatcatggc ttaccgctca ggcggcggtt ttggtgtccg tcttgatacc 1491601 ggaaacagct tccagggcgc cgtgatcaca ccatactatg attcacttct cgttaagctt 1491661 tcaacttggg ctttaacgtt tgaacaggca gctgccaaaa tggtgcgaaa ccttcaggag 1491721 tttagaatca gaggcataaa aacgaacatt ccgttccttg agaacgttgc aaagcatgag 1491781 aagttcctga cagggcaata tgatacatct ttcattgata caacgcctga attatttaat 1491841 ttccctaaac aaaaagaccg cggaacgaaa atgctcactt acatcggcaa tgtgacagtg 1491901 aacggcttcc ctggaatcgg gaaaaaagaa aaaccggcgt ttgacaaacc gttaggcgta 1491961 aaggtagacg ttgatcagca gcctgccaga ggaacaaagc aaattctcga tgaaaaaggt 1492021 gcagaagggc ttgcaaattg ggttaaggag cagaaatctg tccttttaac tgatacgaca 1492081 ttcagggatg cccaccaatc gttattggca actagaatca gatcgcatga tttgaaaaaa 1492141 atcgcaaatc cgacggctgc gttatggcct gaactattca gtatggaaat gtggggaggc 1492201 gcgaccttcg atgtagccta ccgattcctg aaagaagatc cgtggaaacg tttggaagat 1492261 cttcgcaaag aagtgccgaa taccttattc cagatgttgc ttcgctcatc aaatgcggtc 1492321 ggctatacga attatccgga caatgtgatt aaagaatttg tgaagcaatc agctcaatcc 1492381 ggtattgatg tgtttcgtat tttcgacagc ttaaactggg taaaagggat gacgttagcc 1492441 attgatgctg ttagggatac cggcaaagtg gcagaagctg cgatttgtta tacgggagat 1492501 atccttgaca agaaccggac gaagtacgac cttgcatatt atacatcgat ggcgaaggag 1492561 cttgaggcgg ccggagccca tattctcggg attaaagata tggcagggct gttaaaaccg 1492621 caggctgcat atgagctcgt ttctgcgttg aaagaaacga tcgacattcc ggttcacctt 1492681 catacgcatg atacgagcgg aaacggtatt tatatgtatg cgaaagctgt tgaagccggc 1492741 gttgatatca tagacgtggc ggtcagctca atggcgggat taacgtcaca gcctagcgcg 1492801 agcggatttt atcatgcgat ggaaggcaac gaccgccgtc cggaaatgaa tgtccaaggc 1492861 gttgaattgc tgtcccaata ttgggagtcg gtgcgtaaat attatagtga atttgaaagc 1492921 ggaatgaagt ctccgcatac tgaaatttat gaacacgaaa tgccaggggg ccaatacagc 1492981 aacctgcagc agcaagccaa gggagtaggc cttggcgacc gctggaacga agtcaaggaa 1493041 atgtacagac gcgtgaacga tatgttcggt gacatcgtca aggtaacgcc ttcctcaaaa 1493101 gtagtcggag atatggcact ctacatggtg caaaacaatc tgactgaaaa agacgtttac 1493161 gaaaaaggtg aatctttaga tttccctgat tctgtcgtgg agctttttaa aggaaatatc 1493221 ggccagcctc atggcggatt cccagaaaaa ctgcaaaagc tgatcttaaa agggcaggag 1493281 ccgattacag tcagaccggg cgaactgctt gagccggtgt catttgaagc gatcaaacag 1493341 gaatttaaag agcagcataa cttggaaatt tcagatcagg atgctgtggc atatgccctt 1493401 tatcctaaag tcttcactga ttatgtgaaa acgacagaaa gctatggaga catctcggta 1493461 ttagatacac cgacattctt ctacggtatg acattaggtg aagagataga agttgaaatt 1493521 gagcgcggca aaacgctgat cgttaagctg atttcaatcg gtgagcctca gcctgatgcc 1493581 acccgcgtcg tttatttcga actcaacggg cagccgcgtg aagtagtcat taaagatgaa 1493641 agcattaagt cttccgttca ggaaaggctg aaagcagacc ggacaaatcc aagccacatc 1493701 gcagcttcca tgcctggaac agttattaag gtattggctg aagcaggcac aaaagtcaat 1493761 aaaggtgatc atttgatgat taatgaagcg atgaaaatgg aaacaacggt tcaggcgcct 1493821 ttctcaggaa caatcaagca ggttcatgtg aaaaatggtg agccgatcca aacgggagat 1493881 ctgctccttg aaattgaaaa agcataaaaa acaaagagtg tatatcaatg atatacactc 1493941 ttgtttttta tatagaaaat gtggagtgaa acagatggtt agaagagata taaggggact 1494001 tcagagatta tagagtactg tcacaagccc aaaataaaaa gaggcttata cagccaatat 1494061 tttagatgct ttgtagtatg ccgtgcatat ttctttaagc actatctgat ttaaaaggct 1494121 ttaatactta tgttcgcgag ctatagatcc atatgaaatt tctataatca cgatgagaaa 1494181 ggggacagac cgaagtgagc cgctcactga tcatcaagtt cggcgaaggc tggcgattga 1494241 aacgcataaa gcgccaaaaa acaagacata aaaaagacca aagccgccta aggctttggt 1494301 cttgagtcct tatgattgcc tggattcata acggaaacga gcaatcaata ataagaagta 1494361 gcatagaacg ccaaacagac aggcaataaa gaacgagtgg gcaagtgcaa agcccagagc 1494421 cagttcagag tatacgatca taataccgga cagtgcctgt aatgtaatga aaataagaca 1494481 tgagatccat ccccaaaaga tctgtttttg atctttatag gaagtaatag catgaacagc 1494541 ggcaacaata atccatacaa ataaaagtaa ggctgctgct ctgtggccca tttgcaccca 1494601 ttcatggaat tgggtcggaa gtccattgtt cagcgggctg cacagcggca cattaggaca 1494661 tgccagactt gattcagtgt gtcttacata tgcgcctgta tacacaacga tataggaata 1494721 tattaaaatt cctatcatgt gaaattgcat ctttttgccg atttgaagcg gcttaaccag 1494781 tgttctgact gatttatcag cttcaaatat gagcaatgtt aaaataagca ctgaagcaaa 1494841 agaaattaat gagatgccga agtgaagcgc cataatcagc gcgttcgaac cgaatacgac 1494901 agccaatgcg ccaagcaatg cctgaagaaa taaaaagata attgacatga tcgcgagaaa 1494961 cgttgtttca cgaaaaatcg gcgtgatttt tctccatgac caaaacgcaa ggcttagcac 1495021 aaggataata gagattccgc ttgcgaatcg gtggctccat tcaataattg aagccggatt 1495081 cagttcaggg aaaaaacggc cgtgacacag cggccactgt ctgccgcatc cttggccgga 1495141 acctgttttt gtaacgaggg cacccccgat taaaacaatt agcatgacaa atgtcgtcag 1495201 aacaccgaga gcttttaatg ctttattcat acaatattca ccttcttaac atactgctgc 1495261 aattttatat acgttccaag tgtaagcgaa tatgtgtttt gtggcaattc ccagagcctt 1495321 ttgttcacaa aaatataata gaatgacggc ttctggaaaa tgtacacttg attattcatg 1495381 ccgggtctga tagaaataag gtaaacgcaa tgccgatttg gagattgcct tcatctttgg 1495441 taaaattcat aaaaagttca caaataaatt cctgtttgtc gtttaatatt taataggatg 1495501 tttttttaca agatgttatc ttgtatgata gagttgcagg ttattttatt ctcctgcgtt 1495561 aggtttgtaa gggaggttta cgttatggct aactccagaa tcttaaatga tacagctata 1495621 gacggacaaa ttgaagaaac aacggcatgg aaagattttc tgtcccttat taaaataggg 1495681 atcgtcaatt ctaacctcat cacgactttc actggaatgt ggcttgcact gcatatatcc 1495741 ggtttaagtt ttttaggcaa tataaacacc gttcttctta cgttaatcgg gtcttcactg 1495801 attattgcgg gctcctgcgc gatcaataac tggtatgacc gggacattga ccatcttatg 1495861 gagcgtacga aagtaagacc gacggttacg ggtaaaattc agccgagtca ggcgttatgg 1495921 tctggaattt tgctggttgc tttaggattg atcatgctgc tgatgacaac tgtcatggct 1495981 gctgttatcg gttttatcgg agtctttacg tatgttgtat tgtacacaat gtggacgaaa 1496041 cgccgctata cgattaacac agtagtagga agcgtttccg gtgcagtgcc gccgcttatt 1496101 ggatggacgg cagtggaagg gaatatcggt gtcgtagcat gggtgttatt catgatttta 1496161 tttatttggc agattcctca cttcttagca ttggctatta agaaaactga ggattacaga 1496221 gctgcaaata ttccgatgct tcctgtcgta tacggatttg aagtgacaaa aagacaaatt 1496281 attgtgtggg ttgcgtgcct gatgccgctt ccgtttttcc ttggtagcct gggtcttccg 1496341 attgtcattc tcggcttgct gttaaatatc ggctggctga ttcttggctt aatgggattc 1496401 cgctccaaga atatcatgaa gtgggcaacg cagatgttcg tttactcgct taactacatg 1496461 acaatctatt tcgttgccat ggttgtcttg acgcttttct aaaaaataga tatgatgctt 1496521 gttttatcgc ttcaaaataa acgatgacaa ctagtaaatg ccgccttgac ctcttgttta 1496581 atcaggcggc tttactttta tacatagatg gcattttgag taaaaaaact cataatttaa 1496641 gagaagagga aatgtaagtg ctttattggt gataggttgg atggcgatag atttcgatcc 1496701 gctttccgcc tttgtattga ccagaaaagg ggttgggtga aatggtaaag cattggcgtc 1496761 ttattttatt attagcctta gtgccgcttc tattaagcgg atgtggaaaa ccttttttat 1496821 ccacgctcaa gcctgctggc gaggtggctg ataaacagta tgacctgaca gtgctcagca 1496881 cattgattat ggtggttgtt gttgcagtag tatctgttat cttcttttat gtgattgtga 1496941 gattcagaag atcacgggtc ggtgagaaca cgataccgaa acaggtagag gggaataaat 1497001 ttttagaaat cacatggacc gtgatcccga ttttgctgct cattattctt gtgattcctg 1497061 ttgtattata tacgctggag ctagcggaca catcaccaat ggataaaaaa ggccgcaaag 1497121 ctgaggatgc tcttgtagtc aatgttaggg caaatttata ctggtgggag tttgagtacc 1497181 ctgattacgg cattatcaca agccaggagc tgattgtacc gacagatcag cgtgtatatt 1497241 ttaatttaaa agcctctgat gtaaaacatt ccttctggat tccttcagtt ggaggaaaac 1497301 ttgatacgaa tacggataat gaaaataagt tcttcctgac atttgattca aaacgaagca 1497361 aagaggcagg agatatgttt tttgggaagt gtgcagagct ttgcggccct tcacatgcgc 1497421 tgatggattt taaggtgaag acgatgtctg caaaagaatt tcagggctgg acaaaagaaa 1497481 tgaagaacta taagtctaca gcagagagcg atttggctaa gcagggtgaa gaactgttta 1497541 aagagaaaaa ctgcctgagc tgccatgcgg tagagccgaa tgataagcgt gcagaagccg 1497601 ctagaacggc acctaacttg gcgaccttcg gtgaaaggac aaaagtggca ggggtgaaag 1497661 aggccaacaa agaaaatgtg aaggcttggc tgaaggaccc tgacagcata aagccgggga 1497721 acaaaatgac aggcacatat ccaaagctct cagacagcga aacaaatgcg ctttatgaat 1497781 acttaaaagg cttaaaagcg gaaagcaagt agggaagaaa gggagatatt gggggaggtc 1497841 acatatgttg aatgcgctta cagaaaagcg gacgcgcgga tctatgcttt gggattattt 1497901 gacgacggtg gaccataaaa aaatcgcaat tctttattta gtggcagggg gattcttctt 1497961 tcttgtcggg ggaattgaag cgatgtttat cagaattcag cttgcaaagc cggaaaatgc 1498021 gtttctcagt gctcaagcgt acaatgaagt aatgactatg cacggaacga cgatgatctt 1498081 tctggctgcg atgccgctct tatttgcctt gatgaatgcg gttgtgcctt tgcagatcgg 1498141 ggctcgggac gtttcgtttc catttttaaa cgcgcttggt ttttggctct tctttttcgg 1498201 gggcattttc ttaaatctaa gctggttttt gggcggagcg ccagatgcgg gctggacatc 1498261 atatgcctca ctttcgcttc attctaaagg gcacggcata gactttttcg tcctcggact 1498321 ccaaatatcg gggctcggga cgctgatagc cgggattaac tttttggcca cgattatcaa 1498381 catgagggct ccgggcatga cgtatatgag gctgcctttg tttacatgga cgacatttgt 1498441 ggcctcggca ttgattttgt tcgcgtttcc gccgcttacg gttggattgg ctctcatgat 1498501 gctggatcgg ctgttcggaa ccaatttctt taatccggag cttggcggaa atacggtcat 1498561 ttgggaacat ttattttgga tcttcggcca cccggaggtt tatatcctaa ttttgcctgc 1498621 attcggtatt ttttctgagg tcatccctgt gttcgccaga aagcgtttgt ttggctattc 1498681 ttcaatggtt tttgcaatcg tgctcattgg ctttctgggc tttatggttt gggtgcacca 1498741 catgttcacg actggtctcg gcccgattgc aaatgcgatt tttgcggttg caacaatggc 1498801 tatcgcgatt ccgaccggga ttaagatttt taactggctg ttgacgattt ggggaggaaa 1498861 tgtgaagtat acaaccgcta tgctgtatgc tgtctcattt attccatcct ttgtgctcgg 1498921 cggtgtgacg ggagtcatgc tggcagctgc tgcggctgat tatcagtttc atgatacgta 1498981 ttttgtggtt gcgcacttcc actacgtcat tattggcggc gttgtattcg gccttttagc 1499041 cggtgttcat ttctggtggc cgaaaatgtt cggtaaaatt ctgcatgaaa cgatggggaa 1499101 aatttcattt gtattgtttt ttatcggctt tcacctcacg tttttcattc agcattttgt 1499161 cggcttaatg gggatgccgc gccgggttta tacgtttttg ccaggacagg gtctggaaac 1499221 cggcaacttg atcagtacaa tcggggcgtt ttttatggcg gcagctgtta ttcttctgct 1499281 ggtcaatgtc atatggacat cggtaaaagg tgaatatgta ggtgctgatc catggcatga 1499341 cggacgtacg ctggaatgga ccgtttcttc accgccgccg gagtataact ttaaacagct 1499401 tccttttgtc agaggacttg atccgctttg gatcgagaag caggcagggc acaaatcaat 1499461 gacgccggcg gaaccggttg atgatattca tatgccaaac ggctcaatcc tgccgctcat 1499521 catttccttc ggcctttttg tcgcagcgtt cgggctgctg tacagaagtg attacgcttg 1499581 gggcctgccg gtgatcttta tcgggctcgg catcacattt attacgatgc tgcttcgttc 1499641 agtaattgat gatcacggct atcatattca taaagaggaa ctgccgaacg atgataaagg 1499701 ggtgaaggca taatgcaagt tcaagaaaaa ttcaccgcag aaacctttcc agcttctcct 1499761 gaaaaagtaa ccctggaagg gaaaaataaa tttttaggct tttggctttt tcttggcgga 1499821 gagactgttc tgtttgcgtc tctcttcgcc acgtttcttg cgcttcggaa ttcaaatgcc 1499881 ggtgatccgc ctacgacgga aatgttcgat gtgacacttg tattcattgc cacaatgctt 1499941 ctattaacga gcagtttaac gagtgtgtac gcgatgtacc acatgaagaa cttttccttc 1500001 ggcaagatgc agctttggct gggaattacg attttattgg gggcgggctt tttaggactg 1500061 gaaatctatg agttcaagca ttacacccat gaatttggct ttaccatcac aagctctgcc 1500121 cttggttctg cgttttacac gcttgtcggt acacacggcg cccacgtggc atttgggctt 1500181 atgtggatca gcacgcttat gatccgcaat gccaagagag ggctgaatct gtatacggcg 1500241 cctaagtttt acgttgccag cctttattgg cactttattg atgtcgtgtg ggtcttcatc 1500301 tttaccgttg tatatttaat ggggatggtg ggataaacat ggtcgataaa aaaagcagag 1500361 ggcatatcaa tagcgacctt gaatttaaga aaaaaaagca tgcccgggag atgaaatatc 1500421 aagtcctgtc ttttggttta atgatcggtc ttacgattgt tgcatttctg actgtggcca 1500481 cggacggtgt cggcagctgg tttacgattc ctttcattat tttgctagct gcaattcaag 1500541 tcatttttca gctgtattat ttcatgcata tgaatcagaa agggcatgag gcgccggcac 1500601 tgtttttgta ttcaggggtg tttgtcgcgt ttatcactgt gcttgcgttt gtgacaatta 1500661 tatggtggta atttgaacag ccgccggagg tgaagaaatg aatcagttgg agatatttgg 1500721 gtttcgcgcg atgtggagcc cttatctttt ttgtatcctg ttaggcatta cggcgcttta 1500781 tctctatttt tacaggcgaa tgtcttcaaa gccgaatcga ataactggta aagagatggt 1500841 gtgctttctg tcggcgatgc tgtttttata tgcagccgag ggaagcccgg ttgatctgct 1500901 cggacatatt atgttcagtg cgcatatggt gcagatggcc gtcctgtatt tggttgtccc 1500961 gccgctgtta atcgcgggga ttcctgcatg gctctgggaa aaaatcattt tcaggccttc 1501021 aatcaaaccg gttttttcct tttttacgac gcctttaatt gctttgcttt tgtttaacgg 1501081 cattttttct ttatatcatg taccgcttat atttgatact gtcaaaacag atccgtttta 1501141 ccatacatta atcacttggc ttatctttgt gcttgcgttc ttcatgtggt ggccgcttgt 1501201 tcataaggtt gagcgtctac ggcagctcag cggcttgatg aagctgggtt atattatggc 1501261 ggacggtatg ctgctcacac ctgcttgcgc cttgatcatg ttcagcggtg caccgttata 1501321 cgccacctat acagatccgg ctttatgggc tgaggcaatg aggctttgcg tgccagcgga 1501381 tatgatgggg caggtcccat taacagggcc agagatgttg aatacactgc ctttgttaga 1501441 ggatcagcag ctcggagcag tcatgatgaa aatcattcag gaaattgtgt acggtacttt 1501501 tttggccgtt atttttttcc aatgggtgaa gaaagaaagg gaaaaggacg ggcaggagga 1501561 gccgccgtat attcagcaga cgatatcata aaaggtacag cgaaatatgc tgtacctttt 1501621 cgttacattt gaactgtttt taacatgttg gctatgtcct gaatcagtgc cttgcttttt 1501681 gtcacaacct gtacgggaaa ctcttccgtt tctccatatt ctactccatg agggtagtaa 1501741 tgctttccta ggagagggga cattaattga atcacggcgc gcccgcttcc gacatcgcct 1501801 tctgccgcaa taccttgtat ccgcaggtaa aacgtaccct caatcgtcga aaacttcttg 1501861 tcataggtga ctctctcgta atcccattga cccgctctga taagaccttt gctttccatt 1501921 aagtcgtcta gccagctgag ctcagcctta accccttcaa gtccgctttc agtaaacttc 1501981 aacactgacc cctccttata aaaattacct ttcctgacaa tcatagtatg aaagcgttaa 1502041 actttcaatg aatcttcttc ttttgaaagt atgcaaaaat taaattttga cgacaatagc 1502101 actagactaa aggaggttaa acggatgaca aaaataaaag atctgatgac agccgacttg 1502161 caatattgca cggtattaga taatgtatat gaagctgcag taaagatgaa ggacgcaaat 1502221 gtaggagcga taccggtagt tgatgaggac ggggaaacat tggtcggcat cgtaaccgac 1502281 cgcgatctcg tattaagagg aatcgccatc aaaaaaccga actcgcaaaa aatcactgac 1502341 gcgatgactg aaaaacctgt cagtgtggag gaagatgctt cagtcgatga ggttcttcat 1502401 ttgatggcat cgcatcagct cagaaggata ccagttacaa aaaataaaaa actgactgga 1502461 attgtcacgc ttggtgatct ttctttatct gagcaaacga atgaacgtgc cggcagcgcc 1502521 ttatcggata tttccgaagg ggataataga gaagaaggct tttttcatta acacataaat 1502581 ctttgacatg ttaaataggc tgtattgtaa tgggatgtaa acaagagatt gtgaatcgcc 1502641 acgggggtga tagattgaaa aatatattga gagcaatggt tatccttttg attatctgcg 1502701 gaacctatgt tctgtttatt caatatggat ctgttcctga aaagaaatca aatgacagcg 1502761 agcctcaggt gtcgaatgag gaagcgcaaa gcggcaaacg aatacatatg ccgacttcag 1502821 ggttattgtc cttcatgggc aagcacgccg atgaagtaac gaaaaagctt ggggaacctg 1502881 aacgtattga cccttcggct tatgattacg attggtgggt atacaatcaa ggtaaggatc 1502941 aatatatcca aatcggggta ttaaacaata aagtggtcac attattcgcg tcgggtaatg 1503001 atattaacgc caagcctttc aaaattggag aatcaactgg cgaagtattc aagaccaccc 1503061 aggtggcacc atttgtgaat gtagagtata aaggaaattc ctatcggttt gaattttctg 1503121 aagaagatat caatacaaga ccgactgtaa aggtaggaaa gatgtatgtc cagctgtata 1503181 tggacaaatt tgaggggaag ctatccagca tcagggcgtt tgatgcgcag acctttgtaa 1503241 agcaaagacc ttatgaggta gtgtaccgcg gggaattaat taaaccgaaa gccgtttcag 1503301 atgagaaatg gaaaaagatc caaacaacga gcgaaaagca aatccttgat ttgacgaatg 1503361 tcatacgcgt taaacatgga cttgcgaagc ttgagtggga tcagccaacg gcggaagtgg 1503421 catttgggca tagtgaggat atgaaggaaa ataattattt ctcccatgtc tctaaaaaat 1503481 acggctcgct gaaagaccgc ttagaagaag ggcatgttga ttttcagcaa gcgggagaaa 1503541 atatcgcata caattatgtg gacggtccgg ctgctgtaga aggctggctg aatagcgaag 1503601 gccatcgaaa agcgcttctg aattcagatt atacgcatct tggtgtcgga gtagaccgga 1503661 aatattacac ccaaaacttt attaagcgat ggtaatgaaa gccgcggacg aatggttccc 1503721 ggctttttct atttccatac aagctggtct gaatgaatgt gctgatagct tacagataag 1503781 gccgtttccc atcccttcag tcaggctttt tcaccagtgt atagggatat cgctaaaaat 1503841 tcatttggga atgaatatag gcgaacacaa tgcccgacaa aacgatacat tgtagtaggt 1503901 aacgattttc ggagggggtg aggattgtgg cgaatcaaca tgccaatcat tcaatcaatg 1503961 actttaaaca attcgtcaaa aagcatccca agctgataaa agaagtgcgc aaagaacaaa 1504021 gaagctggca ggacgtatat gaaaattggg tcctcttcgg ggagagcgac ccgatttggg 1504081 atccatatcg ggaaccggaa gaagcttctg aagctgtgcc tgaaacaccg caaaaaaatg 1504141 attttgtctc gaaaatggtg acagcggtga aaaagatgga tgtcaatcaa atgaacgaac 1504201 aaatcaataa aatgagccag tcgatctcat cgttgcaaag ccttcttaat acattttccg 1504261 gaagcggaca gaagcattct cagccaggct ctggacagca tcctttttct tttcgaaagg 1504321 attaaaaaag gggagctcat atgcgcaaag aggttcagga atatatttta gcaaacgaag 1504381 aacggaaacg attcatcaga gaacagccga tatggtaccg caggctttca agaaaaccgg 1504441 atgatctgtc ctcctttcag cttgaaatga tgaattttta tgaaaaaacc attccgcatc 1504501 gggtgaatca gtttacgaac gggattcaaa tggcgcaaat gatgatgcaa atgtttcaag 1504561 cgatgcggac aaaagattaa aaggccccga agaagggtct tttttcatgc ggtcataagg 1504621 ttttgttggc ggctgcggtt aagcattttc caattggctg gtttcatggt aaactaacaa 1504681 ctggaggtgc atgttatgta tgcgacgatg gaatccgtgc ggcttcaaag tgaagctcag 1504741 cagcttgccg agatgattct gcagtcggag acggctgaga actaccgcaa ttgttacaag 1504801 cgtctccagg aagatgaaga ggcaggtcgg attattcgtt cttttatcaa aataaaagag 1504861 cagtatgagg atgtacagcg ttttggcaaa tatcatcctg actatagaga aatatcccgg 1504921 aaaatgaggg agatcaaacg tgagctggac ctgaacgata aggtggctga cttcaagaga 1504981 gctgaaaatg agctccagtc cattcttgat gaggtcagcg ttgagattgg gacagctgtt 1505041 tcggagcatg tgaaagttcc gactgggaac ccttattttg acggtttgtc ttcatgcgga 1505101 ggcggctgcg gttcaggcgg aagctgcgga tgtaaagtgt cctgacgaga ctggccgtct 1505161 cgtcttttac atataagaga aaacaggcag gtgattgtat tggagaatag gcgccagggc 1505221 atggttgtgt atctgcactc cctaaagcag agcaaaatgc tgaggaagtt cgggaatgtg 1505281 cactatgtat caaaacgatt aaaatatgtc gtactgtact gtgatatgga ccaaattgaa 1505341 aaaacaatgg acaagattgc gtcttactca tttgtgaaaa aagtggagcc ttcttataaa 1505401 ccgtttttaa aattggaatt cgagtcaaag cttgataagg caaaagaata cgattataaa 1505461 atcggcatat agctataaaa aaatccccgc aggcatctgc ggggtccttc tattccttaa 1505521 tatgttaagg agaaggcaaa gggagaggag aaaccggagg aagaacttat ggggaaacgt 1505581 aagtcttctc cgcggttggc aacaacatcc tctagatgct gttgcttata gtatggacaa 1505641 ggatcatgct gcctatacac ctgtttatca agattagcgt tcattgtttg gaagaatgct 1505701 ttatgttaag ataggattga tttttttcta tgtacatagc ggcgtccggc cgaataaaga 1505761 aacaaaatag cttttagaaa aagtggtgtg gaacatgaga gtaatttctg gatcaaaaaa 1505821 aggccgttca ctaaaggctg tagccggaac atcaacaaga ccgacaaccg acaaagtgaa 1505881 ggaatccatt ttcaatatga tcggccctta ttttgacggg ggcaggggac ttgacttatt 1505941 cgcagggagc ggaggtcttg gaatcgaagc gctttcacgc gggtttgagc attgtatatt 1506001 cgttgaccgt gattttaaag cgattcaaac ggtaaaatct aatttgaaaa cgctggagct 1506061 tacaaaacat gcacaggtat accgcaatga tgcggaacgt gctttgcacg ctgctgctaa 1506121 aagagaaacc ggctttcgcg gaatttttct cgatccgccg tataaggaac aaaagctgaa 1506181 agcactttta actttgattg acgaatatca aatgctggaa gaagacggct ttatcgtcgc 1506241 tgagcatgac agagaggtcg agcttcccga aaccgtagga gatcttgtga tgacaagaaa 1506301 agaaacctat gggttaacag gtgtagcgat ttataaaaag agggggtagt gaggtggcga 1506361 gtatagctgt ctgtcccggc agttttgatc ctgtgaccta cgggcatctg gacatcatca 1506421 aacgcggggc gcatattttt gaacaagtgt atgtatgtgt gctgaataat tcttcaaaaa 1506481 agcctttgtt cagtgtggaa gaacggtgtg agcttctgag agaagtcaca aaagacattc 1506541 cgaacataac agttgaaaca tcgcaaggcc tgttaattga ttatgcaaaa agaaaaaatg 1506601 cgaaagcgat tttaagaggc ttgagagctg tatctgattt tgaatacgag atgcagggga 1506661 catcagtaaa ccgggtgctt gatgaatcta ttgagacgtt ttttatgatg acaaacaatc 1506721 aatattcgtt tctaagttca agcatcgtaa aagaagtggc aagatacaac ggctcggtat 1506781 cagagtttgt accgccggaa gtagagttgg cgcttcagca aaaattcaga caaggatgag 1506841 ggttttgact catccttttt ttgttccgtt tgtcagtctg taagaaaaaa tgataatgta 1506901 cgtaaacagc gcgcatagtg tgacagcagg tccgatctgc acaagcagat tccagccgtt 1506961 tataaaggca gttgacatgt cactgctgtt aagagattta aatacatact gatacggatc 1507021 atgccatgct gtgtaaagag gtttccataa aagcatgacg aagacagcgg cataaacgcc 1507081 ctgcagcaaa cgtgcgataa agaatggttt aaatctaatg tcggtttccg ataaaatacc 1507141 tgccacctga gcttgtacgg aaaagccgct aaacccaaga ataaagctga cgataatggc 1507201 tttttgcaga agagaaacat ctgtctcgct gacaagcttg ctgcctaatg taatttcaaa 1507261 catccctgat aaaagcggaa tgtccaattg agtcggaagc tgaaacaaag tcagtgctcc 1507321 ttttgtgaaa acagacaaaa catcagtcag ctggaccact gacaacagcc gattgaagac 1507381 agaaaataaa ataataaagc cgcctaccat aagaagcgtt tgaacagaag acgtcacggc 1507441 gtcgcctaaa attttaccta agggccgttt ttctgcaagt ctggcggtat gaagagcgtg 1507501 taaagcatct ttgactgaag ggaaaggtat cgttttcttt cttctgagat gctgctcttc 1507561 cttgcggcca taggagcgca ttgttaaacc gacggcaaga ttccccaaat agtgtgcaga 1507621 agctaataaa atgcctagtg atgcgttttg aaagaaaccg acggcaacag cgccgaaaat 1507681 aaagagcggg tttgaagaat tggtaaacga cgcgagccgt tctgcctcta ctcttgaaat 1507741 ctgattttcc tgccgcagac gggcagtgag ttttgcgccc gctgggtttc ctgatgccat 1507801 tcccatagca agaacgaagc cgccgacacc cggcacgcga aagatcggcc gcataaaagg 1507861 ctcaagcaaa acaccgacaa accgcacaat gccaaagccg attaagagtt cggacagaat 1507921 aaaaaatggc agcaatgacg gaaacacaac ctcccaccac atagacagcc cggttttaga 1507981 ggcttcgaat gaggcctgtg gatgtgagat gacagtcgct gttaaaaaaa gaaaaaacga 1508041 ggcaatcaaa agtgtattaa tcttcgacaa gttcattctt acctccccga tgctaaaaat 1508101 gcccaatgac atgtatatca tgataaaata atgtatgatg taaaacggcc aagcagtacc 1508161 tgtcctcttg attctttgta ctaatatacg agcatagggg ttcagtttag accatagaat 1508221 tcggtataca gggaattcag gcaggaggtt aacgctttgg ccaaacctaa aatcgggtta 1508281 gcgttaggat cgggaggggc cagagggctt gctcatctcg gtgtgctttc cagtttacat 1508341 aagcaccaaa ttgaagtgga tatgattgca ggaagcagca tgggcgcttt ggtgggcagt 1508401 ttttacgccg ccggacatga cgtggcaacg atgaaaaaag tagccaaagc ctttaaacga 1508461 aggctttatg ctgattatac ggtgccgaaa ctcggttttt taaaaggtga ccgcgtcaga 1508521 cagcttgtgc atgcttatac attcggaaaa ccgattgaag agctccaaat cccgctgggc 1508581 attgttgcgt gtgatctaca gacgggagaa aagattgtgt tccgaaaagg atcagtgtca 1508641 gatgcagtga gggccagcat cagcatcccg ggtatcttta ttccgcagcg gctggacgga 1508701 cgccttcttg tagacggcgc ggtcgtcgat cgaattccgg tttctgttgt gaaagacatg 1508761 ggagctgata ttatcatcgc ttcggatgtt tccagggttc gaaaaactga aacagcagtg 1508821 catatttttg atgtgattat gcaaagtatg gatatactgc aaaatgaatt agtgcggcat 1508881 caaacaattg ccgcagatat catgattcgc ccttcccttg aaacatacag ctcaagctcg 1508941 tttgccaata ttgaagaaat gatatcggca ggcgaagagg cgacaaaccg aatgatcagc 1509001 aagataagaa aagaaataga gaattgggag ggctcataat ttgctacgta aaaaacattt 1509061 tagctggatg ctcgtcatcc tcatactgat cgccgtttta tcatttataa aacttccata 1509121 ctatattaca aaaccgggag aagcgacaga gcttgcttca ttgataaaag tggagggagg 1509181 ctacccggaa aaaggaagtc tgtccttaat gactgttaaa gtgggaccgg ctaatccatt 1509241 tacatatgtg tgggcaaaga tgcaccctta ttatgaaatt gttcctgatg agagcattaa 1509301 ggaggaaggc gaatcagata aggagtatat gaaaagacag ctccaaatga tgaaaagctc 1509361 gcaagaaaat gcggttatag ccgcctatca aaaggcagga aaaaaagtca gctattcctt 1509421 taacggcata tacgcaagct cagttgtaga aaacatgccg gcaaaaggga aaatagaagt 1509481 cggtgataaa atcatcagcg cagacggcaa aaactatcag tctgctgaaa agctgattga 1509541 ttatatcagc agcaaaaaag cgggagataa agtcacgtta aagatcgaaa gagaagaaaa 1509601 agaaaagcgt gtcaccctta cgttaaaaca atttcctgat gagccggatc gggcaggaat 1509661 cggagtttcg ctttatacag acagaaacgt gaaggtagag cctgatattg attttgaaat 1509721 cgaaaatatt ggcggcccgt cagcagggtt aatgatgtcc cttgaaatct ataatcagct 1509781 gacaaaacca gacgaaacaa aaggctacga tattgcggga acaggtacga ttgatgttga 1509841 cggaaaagta ggcccgatcg gcggcattga tcaaaaagtc gtcgccgcag acaaagccgg 1509901 aaaagacatt ttcttcgcgc caaatcaaaa cggcgccagc aattccgatt ataagaacgc 1509961 agtaaaaaca gcaaaagata ttgattcaaa tatgaagatt gtgcctgttg ataccatgca 1510021 ggatgcgatt gattatttga ataagctgaa agcgaaaagc acctgattct caggtgcttt 1510081 ttctatacat ttaaaaagtg ttgttcatct tcgtcatatc gaatcggtgc atgtccgtat 1510141 tcctgtaggt caaactcagt tctcagcggc tcttctatcg gcaggctgta aatcctgctt 1510201 gcttttacgt ccagatcgag agctggatgg gagaaagagg acagtttgct gacaagcgga 1510261 acagacagtg cttttttctt ttcggataaa taagcctgtc cttttttcgt catgccgaga 1510321 agcctgatat acggcgcctt atcgttgtca agcagctttt gcatatcctg tttttttgtt 1510381 ctggttaaaa tgtgtgtatt catccgctgg agccttgtcc acgtatagcg ttttgttttc 1510441 agcagttcca taaattcctg ataggagctg gattttctga tcgaacgaat aattctgtgc 1510501 tctaaacctt cctccacctc gtatacttgc tgtaattccc gtgccgttac agttgaaagg 1510561 ctgtatttta agtaagaaaa gtagctttca ggtgtatgcc acaatccgaa agatttgcgg 1510621 taagctgcta attcacgtgc agatgcagca gggagaaaac gaaggcaggc ttcgagattc 1510681 tggccaatca tcgcttttct aatgcttgtg gcacttgcta tatggttttc gccttcaggg 1510741 agatcggcat catgatagtc cgaagagatt cgtgccgtag tataaggttt cataggatat 1510801 cccccggtta gaatcgaggt cacatactgg tatcccaaaa tgttatttgg ttttgacaag 1510861 tcaagtgcac tttcagtatg caaaatggag ctgaaggcga tagccgccgc tgctgggtaa 1510921 ctggccccct ttttaagttc ttctttaatt cggtcattca atatatgttt atgctcatca 1510981 ataagctgtg ctgtttctaa aaaaggcttg atatccccat tttcactccc gaaaaacagc 1511041 gcctcacatt caagttcgtt caggatggaa acactgccgc gtgcaaaaat gtctgctttt 1511101 tgcacggcat aaagataagg cagctcaatg acaagatcaa ctccgctttg cagcgccatt 1511161 tttgttcggg cccattttga tacaacagcg ggttccccgc gctgtaaaaa atgtccgctc 1511221 atgaccgcga cagccgtgtc acatccggtt tgcagctttg ctgtttgggc atgataaagg 1511281 tgaccgttat gaaagggatt atattcaacc accaatccga cagctttcat attttttccg 1511341 cctttcttgc tatgtttaaa aacgtatggt acatttgcaa atgaaaactc ttacgcctta 1511401 tttttgtttt aagtgtatgc atagcatatt ccgctgtcaa cgatacttca atggcagcat 1511461 tatgctgtaa agaaaaaata ttgacaaaaa caatcttaaa agctataatc atgtttgttg 1511521 ctttcctgag gtgatacaaa tgaaatggac gatttatcag ctgcatcaaa tgccaaaaca 1511581 aagttttgag tttgatgaaa cagttgagtt aaatgagctg acaaagctga attctgacat 1511641 tcgccgcatt tctcccgttc gggtgaaggg cagagcggat atcaaatcca aacaggtttc 1511701 gtttgatttt acaatttcag gcgaaatgct tttgccatgc tcaagaacac tcgttgatgt 1511761 tccgtatcca tttgaaattt caacaaaaga actgtttata tttcatcaca cggatgatat 1511821 agaagatgat gacgttcaca ttgttgagga cgatactatc gacataactc cgatcgtgaa 1511881 agaagaaatt cttttagaaa tccctatgca aatcttttgt gaatctgaac aagaaaaagg 1511941 agctgctcct caagaaggaa aggattggca agtcatttcg gaagaagaca agaagaatca 1512001 agttgatccg agacttgcag cccttgaaaa gctcttaaaa caagatgatg aatcttaact 1512061 ctttaaggag gtgggaataa tggctgtacc ttttagaaga acttctaaaa tgaagaaaag 1512121 attgcgccgt acacatttca aacttaatgt acctggtatg acagaatgtc cgtcatgcgg 1512181 agagatgaag ttgtctcacc gtgtatgcaa agcatgcgga tcatacaacg gcaaagacat 1512241 aaatgtaaaa agtaactaat gagaaaagcg cagggtgaaa gccctgcgct ttttcttttt 1512301 ctcttcctgt cagcttgcgg aaaatttgtg agtgcaaata gtctatctaa tctattaccg 1512361 gcatatgtat gagataaata agctgacatg gagggagatt gaatttgacc attacaagac 1512421 aagatgcttg gactcaggat gaggatttgc tgctggcaga agtggtgctt cgtcatattc 1512481 gagagggagg aacacagctt tcagcctttg aggaggttgg aagggcgctg accagaaccg 1512541 cggcagcctg tggtttcagg tggaactcgt atgtgagaaa acaataccag tcaggtatag 1512601 agcttgcaaa aaagcaaagg aaagaactga gaaagcaaat cggcgttcat tcggtcaata 1512661 tgccgaattc catgaagcag actgcctcgg catcgtcaga aggaaaacga gatttgtcca 1512721 ttcaggatgt cattcaattt ctcgaacaat tcaaagaaac accgtctgca caagaatttc 1512781 agcttgaaag ggaaaaattg aaggagcaaa tccaatcgct gcaaaaagag cttgaggatt 1512841 tgcggagtga aaatcagaca ttgcggaatc agctagagat gacagaagag gattacaagg 1512901 cactgatcga tatcatggat cgggccagaa aaatggttgt ttcgaaggaa gacggaagaa 1512961 tgaaaaaagc ggctcaagaa acgtaaagaa acgcctgaaa tgaaccggcc ctatagtaag 1513021 aataggccgg ttgttttgat ttctatgcag actctcccgg tgtcatttcg cgatccatat 1513081 caggatgcca gatgagcggg ttttcccctt tgtcccgcgc catatcatac ttaacagttt 1513141 taaagttcat tttgttccaa aattccgctg atttcattct cggatttgtc cggatcggca 1513201 ttttgaatga ttttgcaaat tcaaccaagg ctctcccgta tcccctgttc tggtagcccg 1513261 gaagaacctc aagcttccac agctccaaat aatcctggcg gttgtcaaaa tagggattcg 1513321 atttgccgtt aacttgatac agactcattc gtgctacaag tttatcgcca aaataaatcc 1513381 cgtaaaaagg cgaggtgctg tcattttcaa taatattatc ctgaagttct tcaagcattg 1513441 aaagctcctg aatgccgtat tctttgaatt tcttgaattc ttccagcgtt ttatagttga 1513501 taagcagacg ttctaccttt gtcaaacaaa tctccccctt tgttgtttct acatatattg 1513561 taaacgcttt atttaaaaaa tccaaatatt taaactttaa ttttaagcac atgggatctt 1513621 tgagaagtaa tttcttctta cttctgctat gataatacgt aaatgctaaa ttgggtgtga 1513681 catcatgaaa attggaatta tcggcggagg ctccgttggt cttttatgcg cctattattt 1513741 gtcactttat cacgacgtga ctgttgtgac gaggcggcaa gaacaggctg cggccattca 1513801 gtctgaagga atccggcttt ataaaggcgg ggaggaattc agggctgatt gcagtgcgga 1513861 cacgagtatc aattcggact ttgacctgct tgtcgtgaca gtgaagcagc atcagcttca 1513921 atctgttttt tcgtcgcttg aacgaatcgg gaagacgaat atattatttt tgcaaaacgg 1513981 catggggcat atccacgacc taaaagactg gcacgttggc cattccattt atgttggaat 1514041 cgttgagcac ggagctgtaa gaaaatcgga tacagctgtt gatcatacag gcctaggtgc 1514101 gataaaatgg agcgcgttcg acgatgctga accagaccgg ctgaacatct tgtttcagca 1514161 taaccattcg gattttccga tttattatga gacggattgg taccgtctgc tgacgggcaa 1514221 gctgattgta aatgcgtgta ttaatccttt aactgcgtta ttgcaagtga aaaatggaga 1514281 actgctgaca acgccagctt atctggcttt tatgaagctg gtatttcagg aggcatgccg 1514341 cattttaaaa cttgaaaatg aagaaaaggc ttgggagcgg gttcaggccg tttgtgggca 1514401 aacgaaagag aatcgttcat caatgctggt tgacgtcatt ggaggccggc agacggaagc 1514461 tgacgccatt atcggatact tattgaagga agcaagtctt caaggtcttg atgccgtcca 1514521 cctagagttt ttatatggca gcatcaaagc attggagcga aatacaaaca aagtcttttg 1514581 agctttttcg gtaacatgct atactcattt cggatcacta actatttatt ggagaaagga 1514641 agttctagaa gatgcagcta actgaacttt ccatcaaaaa tcagaatgtg tttgtacagc 1514701 actatataga tggcaaagaa gaaatgtctt ctttttttga ttacagtatt catcataagg 1514761 acatgtggcg cgaaagactg gaagacttat cttcccggtt tttcgcaaga gaggaattgg 1514821 cggcgtactt aacctcttac cataataaat tcggttcaag tgcgatgcag tctgctattg 1514881 agaagctgaa ggacccgtca agtgccgctg tagtcggcgg acagcaggca ggacttttaa 1514941 caggaccgct ttacaccata cataaaatca tttcaatcat tgttttagca aagcaacaag 1515001 aaaaggaact gcaagtgcct gtcataccaa tcttctgggt ggctggagaa gaccacgatt 1515061 tggatgagat taattttgtt cacacatctg aagagaatgg gcctgtgaaa aaaaagctgc 1515121 ctcagtctta ttggaagaaa tcatcagcag cgagtacatc gcttgatcag gaaaagtgtg 1515181 ccgcgtggat agatgatgtt tttgccgctt ttgaagaaac agaccatacg aatacacttc 1515241 tcgacaatgt gaaacgatgt ttaagggaat ctgttacgtt tactgacttc tttgaactgc 1515301 tgatcgcgga tttgttccaa gaagagggct tagttttatt aaattctggg gatccgggga 1515361 ttaaaaagct ggaaacggcc atgttccaaa agattcttcg agaaaatgat gaactcgccc 1515421 gggctgtatc agatcagcag gccttcatgc gtcaagcagg ctacaaaccg attatcgagt 1515481 ccggaaaaga gcaggcgaat ctgttttatg aatacgaaga tgagcgtttt ttaattgaaa 1515541 aagataacgg ccgatttgtc atcaaagagc ttgatctagg atggacgagg gatgaacttc 1515601 atacacatat ggaagaacat ccagagcgtt tcagcaacaa tgttgtaacg agaccgttaa 1515661 tgcaggaatt tctcattccg actttagcat ttattgcagg gcctggggaa atcaattatt 1515721 ggggcgagct caaacaggca tttgcggtga tgggcttcaa aatgcctcct gtcatgccaa 1515781 ggctgaacat tacgatactt gagcggcata ttgagaaaaa actggctgaa cggaatatct 1515841 cattacaaga cgcgattgag cgcggaacgg agaatcaaag agagacatac ttcgagcgcc 1515901 agattccgga agagtttacg gcggtgatgg atcaggcgaa aagccaaatt gaagcgattc 1515961 acaaaacggt ccggcaggag gcgttaaagg ttgatcaaag cttggaacct ttacttctga 1516021 aaaatgccgc ttttattcag gatcagcttc aattcttaga gcgcacggtg atgaagcgaa 1516081 ttgaagaaaa agaaggctac gtcttgaagg attatgaaag aattcaaaat agcattaagc 1516141 cgcttcttgc gccgcaagaa cggatttgga atatcatgta ttatttgaac aggtacggtc 1516201 caaaattctt cacgacattc aagaatctgc cattttcttt tcaaaatcaa catcaagttg 1516261 tcaaactttg aaataaagtt ttaaagaacc ctgactagtt cagggttttt ttttatgggt 1516321 aaacagtgta aaatgaagtt gtggagcgaa gtggtgaata gtggtgagtt aaggagagaa 1516381 agtggggcaa gagatcatgt ttatgggtga atatcagcat accatcgatg cgaaaggccg 1516441 catgatcgta cccgctaaat tcagagaagg cctaggtgag caatttgtgc tgactagagg 1516501 acttgaccaa tgtctcttcg gctaccctat gcacgaatgg aaacaaattg aagaaaaact 1516561 aaaagctctt cctctcacaa agaaagatgc ccgcgcgttt acccgtttct tcttttcagg 1516621 ggcgactgaa tgcgaactgg ataagcaagg cagggtaaat atcgcatcat ctctattgaa 1516681 ttacgccaaa ctggaaaaag aatgtgttgt tatcggggtt tctaatcgaa ttgaattgtg 1516741 gagtaaagta atttgggaac aatacacaga agagcaagaa gattcatttg ctgaaattgc 1516801 tgaaaacatg attgggtttg atatataatg attcttcgtg tataacactc taaaaacaat 1516861 ttcaattcat cctgataaaa ggtgggacca acacaatatg tttcaacaca agacagtact 1516921 tcttcgtgaa accgtagacg gacttaatat taaaccagac ggtacatatg tagactgcac 1516981 actcggcgga gctgggcata gtacatactt attgcagcag ttatccgaga aggggcgttt 1517041 aatcgctttt gaccaagatg atacggcatt acagcatgct aaagaagtgt tgtccgatta 1517101 taaaggacag ctcattctga ttaaaagcaa tttcaggtat ttaaaagaat atttgaatga 1517161 acaaggcgtt acagaagtag acggcatttt atttgattta ggggtgtcct ctccgcagct 1517221 ggatacaccg gagcgcggat tcagttacca tcatgacgca ccgttggaca tgaggatgga 1517281 ccagtcggct acgctttcgg cgaaagaagt cgttaatgag tggcgctatg aggatctcgt 1517341 ccgtattttc tttaaatacg gagaagagaa gttcagtaaa cagatcgcca gaaaaattga 1517401 ggaggcaaga atgaagtctc ctattcaaac tacgggccaa ctggtcgatc taataaaaga 1517461 cgcgattccc gctccagcga gaaggagcgg gggacatccc gctaaacgcg tgtttcaggc 1517521 aatcagaatt gccgtaaacg atgaacttag ggtgtttgaa gaagctttgg agcaggcaat 1517581 tgaggttctg aagccagggg gcagggtatc ggtcattacc ttccactcgc tagaagacag 1517641 aatttgcaaa accactttta aagaaaagtc gtcgcttccg gaacttcctc cgggacttcc 1517701 tgttataccg gaagagtttg aaccggagct gaagctcatc acacgaaaac cgattacggc 1517761 atctcaagaa gagcttgaag agaacaaccg ggctcgttct gccaagcttc ggattgctga 1517821 aaaaagaaaa taacgaaacg cgaacgcaaa attaaaagga ggtcatcagc ctatgagcaa 1517881 tttagcttac caaccagaga aacagcagcg gcatgcgatc agtcctgaga aaaaagtgat 1517941 tgtcaagaaa agggcttcca ttactctcgg agaaaaagtg cttcttgtcc tctttgctgc 1518001 ggcggtgctc agcgtatcgc ttttgatcgt atcgaaggcg tatgcggcat atcaaaccaa 1518061 tattgaggtg caaaagcttg aggagcaaat ttcatccgaa aataagcaaa ttggtgacct 1518121 cgaaaaaagc gttgctgatt taagcaaacc gcagcgcatt atggacattg cgaaaaagaa 1518181 cggcttgaat ttaaaagata aaaaagtgaa aaacatacag gaatgattca aatgccaaaa 1518241 aagaataaat ttatgaatag aggagcagcg attctaagta tttgtttcgc tctctttttc 1518301 tttgtcatcc tggggagaat ggcatatatt caaataaccg gaaaagcgaa cggcgaagtg 1518361 cttgcgacaa aagcgacaga gcagcatgaa aagaaacgga ccatcgaagc gagccgcggc 1518421 tcgattttag accgaaaagg aaaagtcatt gcagaggaca cagcgacgta taaactgatt 1518481 gcgattctcg ataaaaaaat gaccactgat gtcaagcatc ctcagcatgt tgtaaacaaa 1518541 gaaaaaacgg cggaagcatt gtctaaagtg ataaacttgg acaaggccga catccttgat 1518601 atcttaaata aagatgcaaa acaagtcgag tttggctcag ctggccggga tattacgtat 1518661 tcacaaaagc aaaaaatcga aaaaatgaaa ctcccgggca tttcattttt acgggataca 1518721 aaacgctact atccaaacgg agtatttgca tctaatctaa tcggctatgc cgaggttgat 1518781 gaagaaacaa atgaaatttc cggcgcgatg ggattagaaa aagtgctgga taagtatttg 1518841 aaggagcggg acggatatgt gacatatgaa agcgacaaat ccggctggga gctcccgaac 1518901 agcaaaaata aaattacagc gccaaaaaat ggtgacaatg tatatttaac cattgaccag 1518961 aaaattcaaa cctttttgga agacagcatg acaaaagtgg cgcaaaagta taatccgaaa 1519021 aaaatcatgg ccgcagtcgt tgatccgaaa acgggcaaag tccttgccat gggacagcgc 1519081 ccaagctttg atccgaacaa gcgcgatgtg acaaactact ataatgattt gatttcatat 1519141 gcgtatgaac ccgggtccac gatgaagatc tttacactcg ctgctgcgat gcaggaaaac 1519201 gtgtttaatg cgaacgaaaa atataaatca gggacatttg aagttggcgg agcacctgtt 1519261 aaggatcaca ataacggtgt aggctggggt ccgacaacat atcatgacgg cgtcctaagg 1519321 tcgtcgaatg tcgcttttgc gaaactggcg aaagaaaagc tgggatatga ccgcctcaat 1519381 caatatttgc acaaattcaa tttttaccag aaaacaggta ttgatttgcc aggagaagtc 1519441 tccagcaaaa tcaactttaa atatgaattt gataaggcgt caactgcata tggccaagcg 1519501 tctgcggtca caccaattca gcagattcag gccgcaacgg caattgcaaa tgacggtaaa 1519561 atgatgaaac cttatgtcat tgaccatatc gttgaccctg ataaagataa aactatttat 1519621 caaaataagc cggaatcagc cggaactcca atttctgcaa gtactgcgaa aaaggtgcgg 1519681 gatatattag gagaagtcgt tacatcgaag atcggaacag ggcaagctta taaaatcgaa 1519741 ggttttgatg ttgccgggaa aacaggtact gcgcaaatag ccggtaaagg cggatattta 1519801 gacggcacag ataactatat cttttcgttt atgggtatgg cgccaaaaga tgatcctgag 1519861 cttttaattt atgttgctgt acagcagccg caactaaaag caggacaaag cagttcagat 1519921 ccagtatcag aaatcttcaa tccaacaatg aaaaatagcc tgcactacct aaacatcgaa 1519981 ccaactgaaa aatctgactc agataaggaa gaaacaaaag cgcagacaat gcctgattta 1520041 acagatcaaa cggtagctgc tgctcaaaag aaagcaaaag aggagaatct cacaccaatt 1520101 gtcatcggca gtgatgtcgc tgtaaaagaa cagtatccga aagcggatga ggaagttctc 1520161 accaatcaaa aggtcttcct gaaaacgggc ggcaaaatca aaatgcctga tatgacaggc 1520221 tggtcgagaa gagaggttct gcagtacggc gagctcgcgg gaattcatat tgaagtaagc 1520281 ggacaaggct acgctgtcag ccaaagtgtt aagaaagaca aagaaatcaa agacaaaacc 1520341 gtaatcaagg ttaagtttaa aaatcctgat taaaaagaaa gccgtcgtta tgcaggcttt 1520401 ctttttttat gccttcagag gagcatcgtt ctacctgtcc aaattcaggc ataaaatgaa 1520461 acaagcctaa ataaggagtg aacggtctct tgcgcgtctc gaatgtaacg gttagaaaac 1520521 gtttattatt tgttttgctt tttggcgtga tcgtgtttct gatcattgat acaaggctgg 1520581 ggtatgttca gtttgtgatg ggcgaaaaac tgacttcgct agcgaaagat tcctggagcc 1520641 ggaacttgcc gtttgagccg gagagaggcg agattctgga tcggaatggt gtgaagctcg 1520701 caacaaataa aagtgcgccg accgtattcg tcgtgccgcg ccaagttcag aatccgatga 1520761 aaacgagcaa gcagcttgcg gcggtgctca atatgtcaga agaaaaagta tataaacatg 1520821 tgacaaaaaa agcgtcaatc gaaaagatca ctcctgaagg gagaaaaatt tcaaatgaga 1520881 aggcgaaaga aatcaaagcg cttgatttaa aaggtgtgta tgttgcggag gacagtatcc 1520941 gtcattaccc gttcggcagc tttttatctc atgtgcttgg atttgcagga attgacaacc 1521001 aagggctcct tggacttgaa gcctattacg acgatgattt aaaaggggaa aaaggttctg 1521061 ttaagtttta tacagatgcc aaggggaaga agatgcctga tgaagcggat gactatacgc 1521121 cgcctaagga tgggcttgat atgaagctga cagttgattc aaaggttcag acgataatgg 1521181 aaagagagct tgataacgct gaggccaaat atcatccgga cggcatgatt gccgtagcca 1521241 tgaatccgaa aaacggagaa attttgggga tgtctagcag gcctgacttc gaccctgctg 1521301 attaccaatc tgttgatccg tccgtctaca atcgaaatct gccagtatgg agcacgtatg 1521361 aaccgggatc tacctttaaa attattacac ttgcagcagc ccttgaagag caaaaagtaa 1521421 atttgaaacg ggatcaattt tatgataaag ggcatgctga agtggacgga gcgagactgc 1521481 ggtgctggaa aagaggcggg cacgggctgc agacgtatct ggaagttgtg cagaactcct 1521541 gcaacccggg gtttgttgaa ttaggcgagc gcttaggaaa ggaaaagctt ttcaaatata 1521601 tcaaagactt tggttttgga caaaaaacgg ggattgatct ccaaggcgag ggaacaggca 1521661 tcttattccc gcttgagaga gtgggcccgg tggagcaagc aactacggct ttcggacagg 1521721 gagtatccgt cacgccgatt cagcaggttg cagcagtatc cgccgctgta aacggaggaa 1521781 cgctctatac accttatatt gcaaaggaat ggatcgatcc tgttacgaag aaaacggtca 1521841 aaaaacaatc accaatcgca aagaaacaag tcatttctga ggaaacatcc aaacaaatcc 1521901 gctatgctct agaaagcgtc gtcgcagaag gaaccggccg caatgcattt gtagaaggat 1521961 atcgtgtcgg aggaaaaacg ggaactgcac aaaaggttaa agatggaaaa tatcttgaaa 1522021 acaaccatat tgtatcattt atcggtttcg cgccagcaga tgatccgagt ctagtcgtct 1522081 acgttgcggt ggataacccg aaaggcacga ttcagtttgg cggaacggtg gcagcgccta 1522141 ttgtcggaaa tattatgaga gacagtctgc cggaacttgg tgtgaagccc cggaaaaatc 1522201 aaatcgagaa aaaataccaa tggaacgaca caaaaacaat agaagttccg aatgttgtag 1522261 ggatgtctgt ctcagatctt gagtcactat tggtgaatct caatgtggat gcttccggga 1522321 aagggagcaa aatcgttaaa caatcgccag ctgccggaac gaaagtaaaa gaaggctcaa 1522381 agatacgcgt gtatttgact gaagaagatg aaaaggaggc agccgattga ttcgggctgc 1522441 ctattctttt attgcagaaa aaatgctgat atctttcaag attagctgga tgtatccttt 1522501 tatttacgct aaaatatgaa ctgtatgctt aaaatcatta ccacatcatt tgatgtgact 1522561 tcaatgataa aaagaacgaa ttagaatgtt gagaggtttg atacgatgaa acttacaaag 1522621 ctgcttacat acttaacaac cgaaccttct gtaaacgact cacaagaccc tgaaataact 1522681 tcaattgaga tggactccag ggaagtaaag aaagggagtc tttttgtatg tgtaaaaggg 1522741 tatacggtgg atggccacga ttttgcgcaa aaagcagtag aaaacggtgc agcggctatt 1522801 gtggcagaaa gagaggtcga tgtgaatgtt cctgttatta ttgtccggca gtcacttcgc 1522861 gcgctcagcg ttttgtctga tgcgttttac ggacagccga cgaagaagct tcagctgatt 1522921 gggataacag ggacaaacgg caaaacatca acgacccaca tggtcgatga gattctgaaa 1522981 aaagcgggaa aacgcacagg cttgatcggt acaatgtaca tgaaaatcgg agacgaaaca 1523041 cttcctgtta aaaacacgac tccggaaagc gtcacgctgc agaaaacgtt taagaaaatg 1523101 aatgacaagc acgttgacac tgcaatcatg gaggtttctt cccacgcttt gtctttagga 1523161 cgcgtccatg gctgtgatta tgatattgcc gtgtttacga atttaacaca ggaccatctg 1523221 gactatcata aaacgatgga tgagtaccgg catgcaaaaa gcttgctctt ttcccaactt 1523281 ggcggggctt tcaaccatga acatccaaag cgtgccgtcc tgaatgctga cgatgaggcg 1523341 agcgcttatt ttgaaaaggt aacagctgcg catatctcta catacggaat taaaaacgat 1523401 gctgatgtga tggcgaagaa catcagtatc actgcacagg gcacaagctt tgatctcgtg 1523461 acaaacaaag gcacgaagca catcacgatg tctctcgtcg gacaatttaa tgtgtataac 1523521 gtgctggccg ctgttgcgac atgtattgca gcaggcatac cgtttgaaat catcactgag 1523581 gctgttgaag aattgcatgg tgtaagaggc cgttttgaat tggtcaatca gcagcaggag 1523641 tttcctgtca ttgtagacta cgcgcacaca ccggacagcc ttgaaaatgt gctggagaca 1523701 tgcagagaca tgacggaagg aaagctattt gtcgttgtcg gctgcggagg agacagagat 1523761 aagacgaagc gcccgaaaat ggctaaaatt gctgtggagc tggctgacga gccgattttc 1523821 acgtcagata acccgagaag cgaagatcct cgcgcgattt taagagatat ggaagccgga 1523881 gtagagaacg catactatca cagtattgca aaccgcgagc aggcgatctt tttcgcaatt 1523941 gccaatgcca aaaaaggcga cgttgtcctc attgccggaa aaggacatga aacctatcag 1524001 cagatcggaa atgaaacttt cgattttgat gatgctgaag tagcggcgag agccattgtt 1524061 gaactcaata agaataagac gaattcatag gaaagagatg ttactgaata atggagcttg 1524121 aaaagatttt tcatatggaa aaaaatcatg aatatgataa ctacgtatgt cgtttgaaag 1524181 aaacaggagg agaaaaggac aatgcttgag caagtcattc tgtttacaat tttaatgggg 1524241 tttttaatta gtgttctgct ctctccgatt cttattccgt ttttaagaag attaaaattc 1524301 ggccagagta ttagagaaga aggaccgaaa tcacatcaga aaaaatcagg gacaccgaca 1524361 atgggcgggg tcatgatcat actttctatc atagtgacaa caattgttat gacacagaag 1524421 ttttcagaaa taagccccga aatggtgctg cttctgtttg ttacgctagg ctacggtttg 1524481 cttggctttt tagatgatta catcaaggtt gtcatgaagc gcaatcttgg attgacatca 1524541 aagcaaaagc tgatcggaca aattattatt gcggttgtat tttacgccgt gtatcattac 1524601 tacaattttg cgacggatat tcgcattcct ggaactgact tatcatttga tcttggctgg 1524661 gcttacttta tccttgtgct ctttatgcta gtcggcggat caaacgcagt taacctgact 1524721 gacggccttg acgggttatt atccggtact gcggcgattg cctttggcgc ctttgccatt 1524781 ctggcatgga atcagtctca atatgacgta gcgattttct cagttgccgt tgtcggtgca 1524841 gttctgggct tccttgtatt taatgctcat ccggccaaag tttttatggg agatacggga 1524901 tcgcttgcat tgggaggagc catcgttacc attgccattt taacgaaatt agagatcctg 1524961 ctggttatca tcggcggtgt attcgttatc gagacattat ccgttatttt gcaggtcatc 1525021 agctttaaaa cgacaggtaa acgaatcttt aaaatgagtc cgcttcatca ccattatgag 1525081 cttgtcggct ggtctgaatg gagagtagtc gtgacgtttt gggctgcggg acttttgctt 1525141 gccgttttag gaatttacat cgaggtgtgg ttataagtgg aaaatgatca atttttacag 1525201 aaacagcatt ttttaatcct tgggcttgcg aaaagcggat atgcggcggc ctccattctt 1525261 catgaaaaag gcatttatgt tgcagtcaat gatcaaaagc cttttgaaga aaatgaaccg 1525321 gcacaaaagc tttctgaaaa aggaatcgaa gttgtttgcg gagagcatcc agtttctctg 1525381 ttcgatcagc atcaaatcac gattctgatc aaaaacccgg gaattcctta tgaaaatatc 1525441 atggttcagg aagcagagaa acgaggtatt ccggtttgga cggaaattga gctcgcttac 1525501 tacctgacca gcgccaagtt tatcgggatt accggatcga acggtaaaac gaccacgaca 1525561 acgctaattt acgaaatgct caaggctgac tcgcaaaaag cactgattgc cggaaacatc 1525621 ggcacagtcg caagtgaggt tgcctatcat gctgatggag atgaatggat cgttaccgaa 1525681 ctgtcttcgt ttcagctgat gggaacacac gctttcagac cggaaatcag cctgatttta 1525741 aatgtatttg acgcccatct ggattatcac catacgcgcg aaaactatga aaaagcgaaa 1525801 cagaaagtgt accttcatca gactgcttca gataaagcta ttgtcaacca ggatgatgaa 1525861 accgtcgtgc gtcttgctga agccggaaaa gccgaaatcg tcccattttc agtcagcaaa 1525921 acgcttgaac agggcgcata tgtaaaagac agtatgatta tgtttaacgg cgaagccatt 1525981 cttcctctgg aagaggttgt actgcccggt gctcataacc tggagaacat tttagcagct 1526041 attgcagttg tgaaaacggc aggagcatcc aatgaggcgg ttaaaaaggt gctgacaagc 1526101 tttactggtg tgaagcaccg cctccaatat gtcacaactg tgaatggccg caaattttat 1526161 aacgacagta aagcaacaaa cattctggcg acaagcaagg cgctttcagc ttttgataag 1526221 ccggtcattc tgcttgcggg cggactggat cgcggaaatg gttttgatga cttgaaacct 1526281 tatatgaagc atgtcaaagc agtgcttaca tttggccaga cggcgccaaa actcgagaaa 1526341 ctcggcaatg aactgggaat acaacatgtc aaacgtgtcg ataatgttga acaagcagta 1526401 tctgcggcgt ttgcgctctc aaatgaagga gatgtcatcc tgctgtcacc cgcgtgtgcg 1526461 agctgggatc aattcaaaac atttgaagaa cgcggtgaca tgtttataga tgccgtgcat 1526521 atgcttaagt aagggcttgt cttgaagtaa atcggcagcc ctaatgactt taagcttggg 1526581 gtgtcgattg ctttgactac taaaaaaaca tcgcctgatt tgttattggt catcattacg 1526641 ttattattat taacaatcgg attaattatg gtgtacagtg cgagtgcggt atgggcggat 1526701 tataaatttg acgactcatt ctttttcgcg aaacggcagc ttttgtttgc gggaatcggc 1526761 gtcattgcta tgttttttat catgaatgtt gattattgga cttggaggac atggtccaaa 1526821 ttgctgatgg ttatctgctt tttccttctg gtgcttgttt tgataccggg cgtcggaatg 1526881 gtgcggaacg gttcaagaag ctggatcgga gtcggagcat tcagcataca gccttcagag 1526941 tttatgaagc ttgcgatgat tgcattcctt gctaaatttc tctctgaaaa acaaaaaaac 1527001 atcacatcgt tcagacgggg gttcgtccct gcacttggca tcgtgttttc agcatttttg 1527061 attatcatgt gccagcctga cctcggaacg gggacagtta tggtcggaac ttgtattgtc 1527121 atgatttttg tagccggcgc acggatcgcc catttcgtct ttctcgggct gatcggcctc 1527181 agcggatttg tcgggctcgt actatcggct ccatatcgga taaagcggat tacctcatac 1527241 ttaaatccat gggaagaccc gctcggaagc ggatttcaga tcattcaatc gctttatgca 1527301 gtggggcccg gcgggttgtt cggaatgggg ctcggacaaa gcagacagaa gttcttttat 1527361 ctgcctgagc cgcaaacaga ctttattttc gccatcttgt cagaggagct gggctttatc 1527421 gggggaacac ttattttgct cctcttcagc gtcctgctgt ggagaggaat cagaattgcg 1527481 cttggtgcgc ctgatctgta cggaagcttt gtcgcagtcg gcattatttc aatgattgcc 1527541 attcaagtca tgataaatat cggcgtagtc acgggcctga ttcctgtaac aggcatcacg 1527601 ctcccgtttc tgagctacgg aggctcttca ttgactctaa tgctgatggc agttggtgtg 1527661 ctgctgaatg taagccgcta ctcgaggtat taacgaatgt atttccaagc ctcctgtcta 1527721 acatgaagct tggaaacaat tgatgcgata accctgtcca acaaaacagg gttatcgtta 1527781 tgttatagag aaacttagac tgggggaaaa aagaaatgcg aattgcaata agcggaggcg 1527841 gtacaggggg acatatttat cctgctcttg cttttattaa agaagtgcaa agacgtcatc 1527901 ctaatgtgga atttttatat atcggaacag aaaacgggct ggagaaaaaa attgttgagc 1527961 gggagaatat accgtttcgt tcaattgaaa ttacaggatt taaaagaaaa ttgtcatttg 1528021 aaaatgtcaa gactgtgatg cgttttctga agggcgtcaa aaagagtaaa tcgtatttag 1528081 cggaatttaa gcccgatgcc gtaattggaa cgggcggtta tgtatgtggg ccggttgtct 1528141 atgccgctgc gaaaatggga attccgacta ttgtccacga acaaaacagc ctgccgggca 1528201 tcacgaataa gtttctttca aaatatgtta ataaagtagc gatttgtttt gaagaagcga 1528261 aatcacattt tcctagcgag aaagttgtat ttacgggaaa cccgagagcc tctgaagtcg 1528321 tctcaataaa gacgggacga tcattggctg aatttgggct ttctgaagac aaaaaaacgg 1528381 tcttaatttt cggcggaagc cgaggcgctg caccgattaa ccgcgctgtc attgacatgc 1528441 aggatgtgct gaaaacaaga gactatcaag tgctgtatat caccggtgaa gttcactatg 1528501 aaaaagtaat gaatgagctg aaaagcaagg gtgccgctga taatatggtc acaaagccgt 1528561 ttcttcatca aatgcctgag tatttaaagg ccattgatgt cattgtggcc agagccggtg 1528621 cgacaacgat tgccgaaatt actgctctcg gaatcccaag tgttctgatc ccaagtccat 1528681 atgtgacagc gaatcaccag gaggtcaatg cgaggtctct tggccagcat gatgcggcga 1528741 ttgtactgaa agaaacagag ctcagcgggg agaagctgat tgaagcgcta gaccggattg 1528801 tactgaatga gcaaacgtta aaggaaatga gcgaacgaac aaagtcactc ggtgttcctg 1528861 acgcggctgc ccgtttatac agcgtactcg aggaattaaa aaaatagtag aaaagcaaat 1528921 ggaatgcgga ggtttacgat ggagaaagtg atacaggaat taaaagaacg agaagtcggc 1528981 aaggttcttg caaatgaacc gctcgcgaat catacaacga tgaaaatcgg cggacctgcg 1529041 gatgtattgg tcattccaag cagtgtggat gctgttaaag acatcatgga cgtgattaaa 1529101 aaatatgatg tgaagtggac agtcatcggc cgcggatcaa atcttcttgt tttagatgaa 1529161 ggaattagag gcgtagtgat caagctgggg gcgggtcttg accatttgga gcttgaaggg 1529221 gaacaagtaa cagtcggagg cggttattcg gtggtccgcc ttgctacatc attgagcaaa 1529281 aaaggcctgt ccggtttgga atttgctgcc ggcattccag gatcagtcgg cggagcggtt 1529341 tatatgaatg ccggcgctca cggttctgat atgagcgaga tcctcgtcaa agcgcatatt 1529401 ttatttgaag acggaacgat tgagtggctg acaaatgagc agatggattt cagctacagg 1529461 acatctgtac tgcaaaagaa acgcccgggc gtttgccttg aagctgtttt gcagcttgag 1529521 cagaaggata aggaatcaat cgttcagcaa atgcaaagca ataaagacta tagaaaaaat 1529581 acacagccgt attcaagccc ttgtgcggga agcatattca gaaatccgct tccgaatcat 1529641 gccgggaacc ttgtagaaaa agcaggcttg aaaggatatc aaatcggcgg tgcaaagata 1529701 tcggagatgc acggaaactt catcgtcaat gcggggggag catcagcaaa agatgtgctt 1529761 gatctcattg accatgtgaa aaagacaatc cgtgaaaaat acgagattga tatgcacaca 1529821 gaggttgaaa tcatcggcgg aaatcgctga ttcaagttct gactgaagct gttcatatga 1529881 tatactgtaa gcaaacgaca aacggcatca tagtatgccg tttgttttgg aatagacaga 1529941 cttttaacag ctgtttcatt tgaatgaggt gaacaggcaa tgaacccggg tcaagaccga 1530001 gaaaaaatcg ttaacattga agagcggatc cctaaaatta aagagcagag gaaacaaaag 1530061 gcaaaccgcc gtctcatttc atttattatg ctctttttta ttatggtgct gatcattgtg 1530121 tacctgcaaa caccaatcag taaagtatca acaatctctg ttacagggaa tgaaaatgta 1530181 tcaaaaaagg aaattatcga cctttccgat attaacagcg gagatactga gttttggagt 1530241 ttggacaagc aaaaaacaga aaagaagatt cagcaaaata aattagtgaa aaaagcggag 1530301 atcagcaaat cgcttcctaa taaaatcaac attgcaatcg aagaatataa agcgattgct 1530361 tatttagaaa aagacgatgt gtactatgaa gtgcttgaaa acggctcagt tctgccaaac 1530421 gaagtaacgc cggatgatgc cggaccgatt ttagtgaatt ggacaaacgc gaagaagcgg 1530481 tctcaaatgg ccaagcagct cgatgcgttg tcaaattcgt taaaacagtc gatttcagaa 1530541 atttattata cgcctgtaaa aatggatgaa aaccgtatta agttgtacat gaacgacggt 1530601 tatgttgtta cggcatctat taaaacgttt gcagaccgaa tgaagacgta tccttctatc 1530661 atctcacagc taagcagcaa taaaaaagga atcattcatt tagaagttgc cacctatttt 1530721 gaagagtttg ggaaaaacga taaagctgct aaaaaggaag atgaaaattg aggggcaaat 1530781 cagcagtcct tctttccttg attatgctta tcgcaggttt tttgatttca ttttcttttc 1530841 aaatgacaaa agaaaacaac aaaagcgcgg ctgagacgga agagtggaaa aaagaatatg 1530901 cgctgagaga tgaactgctg aaacaagaga aagaaaataa gaagtttgaa aaagaattat 1530961 atcaaaagca aaacaaagtc cgccaggcgg aaaataagct gaagaaagag aagtcggaat 1531021 actataatgt cctcgaagat acagaaaaat acaggatgta tattggggaa gtcggtgtgc 1531081 agggagaagg cgttgaggtg acattggaag atgcgtcata cataccggaa ggggagaatg 1531141 tgaatagtta catcgttcac gaaagccata tcttccaagt agtaaacgaa ctgtatatct 1531201 caggagcggc agctgtcgcc gttaatggac agcgtttgac gcatgattcg tatatcaaat 1531261 gcaatggtcc tgtggtaacg gtagacgggg tgcagcatcc cgctccgttt acggtatccg 1531321 ctattggaga tccagatgtc ctgctgccct cgttaaatat cgctggaggc ctaattgatc 1531381 agctgtcaat ggatcatatt tctgtgtcgg cagaaaaaga gaaaaacgta caaatgaaac 1531441 cgattctgaa aacgaaggaa tgactgaaaa agcgggtgaa atagattgaa aataaagcgt 1531501 tccttcataa gcatcagtgt tcttatggtc atcttcggcc tgatgatatc tgttcagttt 1531561 aattcgttaa agcaccccaa agtccgggat acaagagata tgtgggatat tagggaagag 1531621 ctgacatcag agcagaagaa gcaggaaaag ctgctggctg aaataaacaa atatgacaaa 1531681 ttgctgaata gctattcgca aacgaaagaa atgacaaaag aaaccgcgct aaataatacc 1531741 ttgcaatcct taaaaaaaac agccggcatg accgatataa caggtagcgg aattgtcatt 1531801 acgatttccc cgcttttttc tgaaagctta acaggagagc cgatcgaaaa tccgcctccg 1531861 gatttgctga aaaagctgat aaatgaactc aactcctacg gtgcagagca tatctcgatt 1531921 aatgagcgaa gagttgtgaa tcatacagtc atcagagata taaacggcac tacaaaaata 1531981 gacggatacg cccttgacga ttatccttta acagtaaaag tgcttgccaa agatccggac 1532041 atgttacaca gcagagtgaa ggggtcaggc cttgaggatc tttttgcatc tgaaaattta 1532101 gcattaaaag ccggtaaatc tgaaagcaaa ctaacattaa aagcatatga cagaccactg 1532161 gacgtacaac agctgaaact gcttaaagac tgaaaaggag gagaattgtc atgtggctgc 1532221 ccgtgttggg actggtgctc ggaatagcga ttggactaat gacaaactta acgataccga 1532281 gtgaatactc aaactattta tcgcttgcgg tgcttgccgc acttgataca ttaatcggcg 1532341 gaatcagggc gcatttacaa ggtacatatg atgaaatggt atttgtttcc ggtttctttt 1532401 ttaatattat attggcaata agtttagctt ttctgggagt ccatcttggt gtagacttgt 1532461 atttagcagg tatattcgca tttggagtca gattatttca gaatatagcc gttatcagaa 1532521 gaaatctact aacaaagtgg actctttcta aaaaaaataa aaaaaatgtg atataaaaga 1532581 ggatatacat aggatataac gaatattttc aataaacata aaatgtgaaa agcacataaa 1532641 aatattctgt tgttattttt tgttacacac ttgtaaagcc acattcattg tattgttgtt 1532701 ccgcaaataa tagaatagaa atgatcgaaa tgtgaggagg tgccatagaa tgaacaacaa 1532761 tgaactttac gtcagtcttg acatcggtac gtccaataca aaagtgatcg tcggagaaat 1532821 gacagatgat tcccttaata ttatcggtgt gggaaatgta ccgtctgaag ggttgaaaaa 1532881 aggctcaatc gttgatatag atgagaccgt tcattctata agaaaagcgt ttgaccaagc 1532941 tgaaagaatg gtaggttttc cgcttagaaa agctattgtc ggcgttaatg gaaattatat 1533001 caatattcaa gatacaaacg gtgttgtagc agtttccagt gaaaataaag aaattcaggt 1533061 tgaagatgta cgccgtgtca tggaggcggc acaggttgtt tccgtaccgc atgaacagct 1533121 gattgttgac gtcattccta aacagtttat cgtagatgga agagatgaaa tcaccgaccc 1533181 gaaaaaaatg ctgggtgtgc gtttagaagt agagggcacc ttgatcaccg gttcaaaaac 1533241 aatcttacat aacttactcc gctgcgttga aagagctggt attgaaataa ctgatatttg 1533301 ccttcagccg ctggcagccg gttctgctgc attatcaaag gacgagaaaa accttggtgt 1533361 ggctctcatt gatatagggg gagggtcaac aaccattgcc gtattccaga acggacatct 1533421 cacttctacc cgtgtcattc ctctcggagg cgaaaatatc accaaagata tctccatcgg 1533481 attgagaacg tcaacagaag aagcagaacg cgtgaaaaag caacttggac atgcctacta 1533541 tgacgaagcc tcggaagatg aaatatttga ggtaaccgtt ataggcacca atcaaaaaca 1533601 aacatttaca cagcaagaag cagcgaatat cattgaagcg agagtagagg aaattcttga 1533661 aattgtttca gaagagcttc gcagtatggg aattaccgat ctgccgggag gcttcgtgct 1533721 gacaggagga caagcagcta tgccgggtgt catgtctttg gcacaggatg tgctgcaaaa 1533781 caatgtcaga gtggcaagcc cgaattatat cggtgtaaga gatcctcaat atatgacggg 1533841 agtgggcctg atccaattcg cctgccggaa tgcaagaatc caaggcagaa aaataggctt 1533901 taagatgcct gaagaagcga tacaggaaat cgcagtctca tcatctgagg aacaagagca 1533961 gcatcatcac caaaatgagg tgcagcagcg gccaaaagga aaacaaaaaa cacaagccga 1534021 acataataaa cagagcaaaa tgaaaaaact attaagcatg ttttgggaat agatagatag 1534081 tcattcggca gattaggagg atttagcatg ttggagttcg aaacaaacat agacggctta 1534141 gcatcaatta aagtaatcgg agtaggaggc ggcggtaaca acgccgttaa ccgaatgatt 1534201 gaaaatgaag tgcaaggagt agagtatatc gcggtaaaca cggacgctca agctcttaac 1534261 ctgtcaaaag cagaagtgaa aatgcaaatc ggcgcaaagc tgactagagg attgggagca 1534321 ggtgcgaatc cggaagtcgg gaaaaaagcc gctgaagaaa gcaaagagca gattgaagaa 1534381 gcacttaaag gtgctgacat ggtattcgtg acagctggta tgggcggcgg aacaggaaca 1534441 ggtgccgcac cggttatcgc acaaatcgcg aaagacttag gcgcattaac agtcggcgtt 1534501 gtgacaagac cgtttacctt cgaaggacgc aaaagacagc ttcaggctgc aggcggaatc 1534561 tcggcaatga aagaagcggt ggatacactg atcgtgatcc cgaacgaccg tatccttgaa 1534621 attgttgata aaaacacacc gatgcttgaa gcattccgcg aagcggataa cgtacttcgc 1534681 caaggggttc aaggtatttc tgacttgatt gctacacctg gtcttatcaa ccttgacttt 1534741 gctgatgtga aaacaatcat gtcaaacaaa ggatctgctt tgatgggtat cggtattgct 1534801 actggggaaa atcgcgcggc agaggcagca aaaaaagcaa tttccagccc gcttcttgaa 1534861 gcggccattg acggtgcgca aggcgtcctc atgaacatca ctggaggaac aaacctcagc 1534921 ctatatgagg ttcaggaagc agcagacatt gtcgcttcgg cgtctgatca agacgtaaac 1534981 atgattttcg gttctgttat taatgaaaat ctaaaagatg agattgtggt gacagtgatt 1535041 gcaaccggct ttatcgaaca agagaaggac gtgacgaagc ctcagcgtcc aagcttaaat 1535101 caaagcatca aaacacacaa tcaaagtgtt ccgaagcgtg agccaaaacg tgaggaacct 1535161 cagcagcaga acacagtaag ccgtcatact tcacagccgg ctgatgatac gcttgacatc 1535221 ccgacattct taagaaaccg taataaacgc ggctaatgta aaggacaaaa tcgttttcga 1535281 ttttgtcctt ttttgttttt ctcttcacac tttccttctt ataaagtctt tttccctatt 1535341 gcttccttcg cttagtaaca aaacagataa ttagacccat ttatttttgt gacattttta 1535401 tcattttcat atatatggaa attgaatgac atgaaacgac aatatctgta attcagattg 1535461 tctacagtta atatacagcg atgttctgac aaaccattca ttattaaaag gagggacgac 1535521 acttttttta aaaagcatgt tgaaaaaggg ggatgaaaat gaggaaaaaa acgaaaaaca 1535581 gactcatcag ctctgtttta agtacagttg tcatcagttc actgctgttt ccgggagcag 1535641 ccggggcaag cagtaaagtc acctcacctt ctgttaaaaa ggagcttcaa tctgcggaat 1535701 ccattcaaaa caagatttcg agttcattaa agaaaagctt taaaaagaaa gaaaaaacga 1535761 cttttctgat taaatttaaa gatctggcta acccagaaaa agcggcaaaa gcggctgtta 1535821 aaaaagcgaa atcgaagaag ctgtctgccg ctaagacgga atatcaaaag cgttctgctg 1535881 ttgtgtcatc tttaaaagtc acagccgatg aatcccagca agatgtccta aaatacttga 1535941 acacccagaa agataaagga aatgcagacc aaattcattc ttattatgtg gtgaacggga 1536001 ttgctgttca tgcctcaaaa gaggttatgg aaaaagtggt gcagtttccc gaagtggaaa 1536061 aggtgcttcc taatgagaaa cggcagcttt ttaagtcatc ctccccattt aatatgaaaa 1536121 aagcacagaa agctattaaa gcaactgacg gtgtggaatg gaatgtagac caaatcgatg 1536181 ccccaaaagc ttgggcactt ggatatgatg gaactggcac ggttgttgcg tccattgata 1536241 ccggggtgga atggaatcat ccggcattaa aagagaaata tcgcggatat aatccggaaa 1536301 atcctaatga gcctgaaaat gaaatgaact ggtatgatgc cgtagcaggc gaggcaagcc 1536361 cttatgatga tttggctcat ggaacccacg tgacaggcac gatggtgggc tctgaacctg 1536421 atggaacaaa tcaaatcggt gtagcacctg gcgcaaaatg gattgctgtt aaagcgttct 1536481 ctgaagatgg cggcactgat gctgacattt tggaagctgg tgaatgggtt ttagcaccaa 1536541 aggacgcgga aggaaatccc cacccggaaa tggctcctga tgttgtcaat aactcatggg 1536601 gagggggctc tggacttgat gaatggtaca gagacatggt caatgcctgg cgtgcggccg 1536661 atattttccc tgagttttca gcggggaata cggatctctt tattcccggc gggcctggtt 1536721 ctatcgcaaa tccggcaaac tatccagaat cgtttgcaac tggagcgact gatatcaata 1536781 aaaagctcgc tgacttttct cttcaagggc catctccata tgatgaaata aagccggaaa 1536841 tatctgcacc gggcgttaat attcgttcat ccgttcccgg tcagacatat gaggatggtt 1536901 gggacggcac atcaatggca gggccgcatg tatccgctgt tgctgcactg ctgaaacagg 1536961 cgaatgcctc actttctgtt gatgagatgg aggatatatt aaccagcacg gctgaaccgc 1537021 tcacggattc aacatttcct gattcaccga ataacggata tggccatggt ctggtgaatg 1537081 cttttgatgc tgtatccgct gttacagatg gattagggaa agcggaagga caagtttctg 1537141 tagaggggga tgaccaagag cctcctgtct atcagcatga gaaagtaact gaagcttatg 1537201 aaggtggcag cctaccactg actttgacag ctgaagacaa tgtgagtgtg acatctgtaa 1537261 agctgtccta caagcttgat caaggtgaat ggacagaaat aacggctaaa cgaatcagcg 1537321 gtgatcatct aaaaggaacg tatcaggcag agatcccaga tataaaagga actaaactaa 1537381 gctataagtg gatgattcac gattttggcg gtcatgtcgt ttcgtctgac gtatacgatg 1537441 taacagtgaa accaagcatc acggcgggat ataagcagga ctttgaaact gcacccggcg 1537501 gctgggttgc gagcggaaca aataataact gggaatgggg agttccgtca actggcccaa 1537561 atacagcagc atccggagaa aaagtatatg gaacgaattt gacaggaaat tatgccaact 1537621 cagcaaacat gaaccttgtt atgcctccta ttaaagcacc tgattcagga agtctgttcc 1537681 ttcaatttaa aagctggcac aatttagagg atgattttga ttacggctac gtttttgttc 1537741 ttccggaagg tgaaaagaat tgggagcagg ctggtgtcta taacggaaag acatcaagct 1537801 ggacggacga agaaattgat ttatcggctt ataaaggcca aaacattcaa gtgatgttta 1537861 accttcaatc tgatgaaagc attgcaaaag agggctggta tattgatgat gtagtgcttt 1537921 ctgacaaatc agccggaaaa acagtcaaaa agaataagct gggcgtcgaa aagccgtctg 1537981 gaaagcaaaa gaaaaagcca gtaaatccga aaaaggctaa gccatctgca aacacagcgg 1538041 taaaacatca gaacaaggct atacagcctc aagttttgcc gctcaaggca caagtcagtg 1538101 tagtggaaac aggaaaatca acatattcag atcaatccac agggcagtac acgctgaagc 1538161 acaaagcggg agactatacg cttatggcag aagcatatgg ttatcagtcg aaaacacaaa 1538221 aagtatcttt aaagacggat cagacgacac aagctaattt tacgttagaa gagatgaaga 1538281 agggcacatt aaaaggcacg gtcatcaata aaacgacagg agagccggta acaggcgctt 1538341 ccgtttatgt tgtagaggat gctgcggtgg aaccggctat gacaaacgac aaaggtgaat 1538401 atatgctgga ggcctatgaa ggcgcttata cgattaaagt cgctgcaccg ggttattaca 1538461 gtgatgaatt ttccgttgag ttaaaaggtg atgttacaaa agaaactgca ttgaagcctt 1538521 tcgtcggtta tccgggtgaa attgcatatg atgacggaac agcggagaat gccaattcct 1538581 attttgctgc cggtaacgga tgggcggtaa aaatgacgct cgctgacggc aaggacaaag 1538641 gcatgcttac aggagggctg ttcagattct gggatacaga gttccctgat ccgggcggca 1538701 cagagtttaa ggttgaggta tacgatgcca caggaaaaga cggagcaccg ggcaagaaaa 1538761 ttgcagggcc atttaacgcg gaagctcttc gcaatggcga gtggactaag gtagatctca 1538821 gttcaaaagg gattatggtc gataaagatt tttatctcgt atatatccag tcgaaacctg 1538881 atccgtattc acctggattg gcaatggatg aaaccggcca gaattccggc cgcaactggc 1538941 agtatataga tggaaagtgg cagccaggtg acaaagcgga tggcaactat atgattcgcg 1539001 cattagttga ttatgaagct gctgtacctg agattacttc accgacagac aaatcataca 1539061 caaataagga tagcgtcact gtaaaaggaa acgcttctcc tggcacaacg gtacacattt 1539121 ataatggaga gaaagaagca ggagaaacga aagctgctgc ggatggcacg ttccatgcag 1539181 gcatcatact caacaagggt gaaaatgagc tgacggcaac tgcatcaact gacaacggaa 1539241 caacagatgc ctccagccca atcacggtca cgcttgatca agaaaagcct gaattaacac 1539301 tggacaatcc aaaggatggc gggaaaacaa ataaagaaac gctgactgtc aaaggggctg 1539361 tatccgatga caatctgaaa gacgtcaagg tgaatggcaa aaaagcaaca gtagctgatg 1539421 gttcatactc agcccgtatt cttttggaaa atggaagaaa tgaaatcaag gtaattgcta 1539481 cagacttggc aggcaacaaa acgacgaaaa agacagtcat tgatgtgaac tttgacaagc 1539541 ctgtcatttc cggcttaatt ccgggagagg ataaaaactt aaaagccggt gaatctgtga 1539601 aaatcgcttt ctcaagcgct gaggatttag atgcaacgtt taccattcgt atgccgctga 1539661 ccaatgcaag agcgagtgtg caaaatgcca ccgaactccc gttaagagaa atctctccgg 1539721 ggagatatga aggctattgg actgccactt cttctattaa agcaaaagga gcaaaagtag 1539781 aagtgatcgt ccgagatgat tatggaaatg aaacaagaaa aactgcgaat ggaaaactta 1539841 atatgaacac agaaaattaa gtggaaaaaa agctgccgtc attggcagct ttttttatat 1539901 cctctcatta tacttcctcg acaaattaag cagatttccc tgaaaaattg tattttcctc 1539961 tcaacattaa ttgacagact ttcccacaga gcttgcttta tacttatgaa gcaagaaggg 1540021 gaacagcgtg aggcaagaaa gaaaggagtc agatgtgaaa atctatttag atgtcatttg 1540081 gctgttaaac ttttgttttg atgcactttt gcttttgctc acggcattta ttttaaaacg 1540141 gcatgtaaaa aaaagaagac tggtaggcgg agcgttcatc ggttccagta ttgtcctttt 1540201 gatgtttact cctttttcgc cgattgttga acatccggct gggaagctag ctttttcagt 1540261 tgtgattgtg gtggtgacat ttggctttaa aagatttcgg tttttctttc aaaatttgtt 1540321 ttccttttat tttgccactt ttttaatggg gggaggaatt atcggagccc attctttgct 1540381 gcagtcaaat tctattgttc aaaacggtgt catgattacc aatcaaacag ggtttggaga 1540441 cccgatcagc tggttgttta ttgttggtgg ctttccagca ttatggtttt tttctaaaag 1540501 aagaattgaa gatattgaaa caaaaaacat tcaatatgag gaacgagtca gcgtgcaggc 1540561 agatttgggc agccaaacac ttcatgtcag aggcctgatt gattccggta accagctgta 1540621 cgatcctctt acaaaaacac cggtaatgat catttacatt gataaactgg agccgatttt 1540681 cggaacagcc gaaacgatga tcattcgaaa cacagaccca ttggaagcca tcgaacagct 1540741 cgatgattcc tttcgctttt tagataaaat gaggttgatt ccatacaggg gagttggtca 1540801 gcaaaatcaa tttttattat gcgttaaacc ggatcacgta acgattatga caaaagaaga 1540861 aatgatttct gcagataaat gtttaatcgg tatcagcaca acaaagctgt cggcagatgg 1540921 agagtttgac gcgattattc atccgaaaat gctttcgggc aaggctgtca aacacgtttc 1540981 ataatgttcg caaatgtccg ttacttatca tactcaaacg gcgtgacatt tagaagggag 1541041 aggaagatga aaaaactgaa attacggttg acgcacctct ggtataagct gctgatgaaa 1541101 cttgggctga aaagtgatga agtctattac ataggcggga gtgaagccct gccgcctcca 1541161 ttatctaaag atgaggagca ggttttgtta atgaagctcc caaacggcga tcaggcggcg 1541221 cgcgccattc taattgaacg caatttgcgt ctggtcgtat atatcgcccg taaatttgaa 1541281 aatacgggaa ttaatataga ggatttaatc agcatcggta ccatcggtct aatcaaagct 1541341 gttaatacat ttaatccaga aaagaaaatc aagcttgcta cctatgcctc ccggtgtata 1541401 gaaaatgaaa tcctgatgta tttaagaaga aataacaaaa tccgttcaga ggtttccttt 1541461 gatgaaccgc ttaatattga ttgggacggc aatgagcttt tgctttctga tgtgctcggc 1541521 actgacgatg acatcatcac taaagacata gaagctaacg tcgataaaaa gcttttgaaa 1541581 aaagcgcttg aacagcttaa tgagagagaa aagcaaatca tggagctgcg gtttgggctt 1541641 gtcggtgaag aagaaaaaac ccaaaaggat gtagcggata tgatggggat ttctcagtct 1541701 tatatttcgc ggcttgagaa aagaattata aaaaggttga gaaaagagtt caacaaaatg 1541761 gtgtaaaaaa ttttatggtt agaacccctt gattttacag ggatttcctg atttcgacag 1541821 tttttcggtc tgagtgcagt gcatattttt cccacccaag gagatactta acgttgtaca 1541881 gcagctcctg tagggaggga aaaaagtgtc gagaaataaa gtcgaaatct gcggggtgga 1541941 tacctccaaa ttaccagtac tcaagaatga agagatgaga aagctgttta ggcagctgca 1542001 ggatgaaggc gatgattcag caagagaaaa gcttgtaaac gggaacttgc gtcttgtctt 1542061 aagtgtcatt caacgattta ataacagagg ggagtatgtt gatgacttat ttcaagtcgg 1542121 ctgcatcgga ctaatgaaat ccattgataa ttttgaccta agccacaatg ttaagttttc 1542181 aacatacgct gtacctatga ttatcggaga gatccgcagg tatttacgtg ataataaccc 1542241 gatccgtgtc tcaagatcac tccgggacat cgcttacaag gcgcttcagg taagagagcg 1542301 gttaatcagt gagacaagca aggagccgac tgcagaagac atcgcaaaag ttcttgaagt 1542361 accgcatgag gaaattgtat ttgcgcttga tgccattcag gatccggttt ctctatttga 1542421 accgatctat aacgacggcg gagacccgat ctatgtgatg gaccaaatca gtgatgagcg 1542481 taatacagat tcacaatgga ttgaagagct ggctttaaaa gagggcatga gaaggctgaa 1542541 cgatagggaa aaaatgattt tgagaaagcg attcttccaa gggaaaaccc aaatggaagt 1542601 cgccgaggaa atcggaattt ctcaagcgca ggtgtccaga cttgaaaaag cggctatcaa 1542661 acaaatgaat aaaaatattc atcaataatg aaaagccttt aaaacgatgt tgttttaaag 1542721 gcttttctat tgattatgga tggtttacgt tttggaaaaa gtaaggtatc ctagttcgta 1542781 caaagtttta tgaaaattaa aacaattata aaaggcaata aagaggagga ccacgatgat 1542841 tttgcagctt gacaatgtct cactaaaacg gaatgggaaa tggatactga aagatattca 1542901 ttggaaggtg gaagaaaagg aaaattgggt gctttacggc ctaaatggcg ccgggaagac 1542961 agcgctgtta aatatgcttt gctcatatta ttttccaaca tcaggcgaga tgcaggtgct 1543021 cggccatgaa tttggcaaaa cagagcttgg ggaaaagctc agacgtaaaa ttggcctcgt 1543081 ctcagcagct cttcagcaaa aattgtatcc ggcagattca gcttttgaaa ttgctttgag 1543141 cggagcttac gcttcgattg ggttatatga aacgccaagt aaggaaacca gggaaaaagc 1543201 gataggtttg ttagaggact tgggagcaat tgaatatgcc gatcgccgct atgaaaccct 1543261 ttctcaaggg gaaaaacaaa gagcattgat tgctagagca ctaatggccg atccggagct 1543321 gctgatactg gatgaaccag tcacaggact ggattttatt gcccgggaaa agctgttaga 1543381 tacgattaca tacattgcaa acaaagaaaa tgcaccatct atcctttatg tgactcatca 1543441 tgctgaagaa attttgcctg tctttgataa agccctttta ttaaaacagg gagaggtttt 1543501 tggatccgga gaaataaagg aaatgcttac tgatcaaata ctttccgctt tttttgatac 1543561 gccaatccat gtattatgga atcaggatcg gccgttttta acaagagctg agccgataac 1543621 gaatgcctga caaatatata tagattcatc ctaggggtgc tttgcgaagc tgagagagac 1543681 tttgtctcaa cccttttgac ctgatctgga tcatgccagc ggagggaagc ggtgaaaagc 1543741 ggagtacatc ggactccgtt tgtttttatt aagccgtttc atcacatttg aaacggcttt 1543801 tttgatttta aagaatagga gcggatttac attggatcaa caaatatact ctttgcaaaa 1543861 aaaagtggaa gaacataagg aggagcttat tcagcttgcg aaaacgctga tttcttatca 1543921 aacacctgct ccgcctgcaa gaaatacaga gggcattcag tcttggattg cgggatattt 1543981 aaatgaattg ggattctcga tcgacaaatg ggatgtgtac cctggagatc ccaatgttgt 1544041 agggaagcta aaaggaacag attcagcaga ttattatagc ctgattatca atggccatgt 1544101 agatgtggca gaggtaaaag aggatgaaga atggaagcac gatccgtttc atcccattga 1544161 aaaaaacggt ctcttaatcg ggcgaggcgc ttccgatatg aagggcggaa tggcttgtgt 1544221 gctgtttgct gtcaaattaa ttcgtgaagc aagcattgaa cttccaggtg atctgattct 1544281 gcaatcggtt attggggagg aagttggaga ggccggcaca cttgaatgct gcaagagggg 1544341 ctaccacgct gattttgcaa ttgtcgcgga tacgagcgat atgcatattc aaggccaagg 1544401 cggtgtcatt acaggctgga tcgaaatcaa aagcagtcaa acatttcatg atggaacgag 1544461 acggaatatg attcatgcag gcggaggaac attcggagca agcgcaattg aaaaaatggc 1544521 aaaaatcatt gcggggctcg gtgaacttga gcgccactgg tctattatga aaagttatcc 1544581 cggttttaaa ccaggcacaa atacgattaa cccggcagtt atagaaggcg gcagacatgc 1544641 ggcttttata gcggacgaat gccggctgtg gatcacagtc catttttatc cgaatgaaac 1544701 ccatgaccaa gtggcagcgg aaatagaaga ttacgtcaat cggctgagtg acagtgatat 1544761 ttggcttagg gaaaaccgcc ctgtattcaa gtggggaggc tcatctatga tagaagacag 1544821 gggagaaatt tttccggcat tggaagttga ccctggccac ccaggcgtct tagcgctaac 1544881 tgcctctcat cagaaagtga aacgggagtg tccaattatt gacgtttctc aatcagttac 1544941 agatggcgga tggctgtatg atgccggtat tccatgcgta atatacggtc ctggagatct 1545001 gcacaatgca cactctgtga acgagaaggt atcgattgag cagctagtag agtatacaaa 1545061 aattatactc gattttatca tcagctggtg cagccggaaa aaagaacaat gacatgaaaa 1545121 tttcttcttg ctgacaaggt tcagcctgcc cgttcatata cttgaacaaa aggacggaaa 1545181 aaggacgtga tggaatgatc agcatttcag aatttcaggt aaaggatgtc gtcaatgtct 1545241 caaacggaaa aaagctgggg agtattggtg atattgatat caatgtgacc actggaaaaa 1545301 ttcaggcgat catactcgga ggaaatggga aagttctcgg attttttgga aaagaagagg 1545361 aattggtcat tccatggcga aatatagtaa aaatcgggga agatgtaatc ttagtccgat 1545421 taagtgaacc acatgcataa acctgcttgt ctgccgcaga ttggcaaatg ccggaagtct 1545481 cgattcttcc ggcacatttc atttagaaat atgcaaatcg gcgctcaacg aatgcagtaa 1545541 gatgtggtaa aataagtggg aaattccgct tttttaaatg tttgtcgaaa ggttggatca 1545601 tcatgaatac atatcaccca ttcagtctta ccacaccctc gacactcatg atacaagact 1545661 gggctcaaac gaatcaaaac aacaaagagg tcattgccgg atttacgaca aaaaacggcg 1545721 gtgtcagcca aaagcctttt gaatcgttaa atacaggatt gcacgttcat gacaaagatg 1545781 cagatgtagt taaaaatcgt gaatatattg ccgatatgtt taatactgat ttgcagtctt 1545841 gggtattcgc tgatcagaca catgataatc gcgttcagaa agtgacgcag agggataggg 1545901 gaaaaggcgc ccgtgagtat cacacggctc taaaagcaac ggacgggatc tatacaaatg 1545961 aaaaaaatgt atttttagca ttatgctttg ctgattgtgt gcctcttttc ttttatgatc 1546021 cggttaagtc gcttgtcgga gtcgcccatg ccgggtggaa aggcaccgtc aaacagattg 1546081 gcagagaaat ggtgaagcaa tggactgaga aggaaggttc aaatccctca gatatttacg 1546141 ctgttattgg cccgtctatc agcggagcat gctatacggt agacgaccgc gtcatggatg 1546201 ctgtccgcgc attgccggtt tcagcagacc ttgccgccaa tcagacggca aaggcacaat 1546261 atcagcttga tctgaaagag ctgaaccgtc ttatactgat ggacagcggt ttggcaagtg 1546321 aacaaatttc tgtcagcggt ttatgcacgg aaagcgagcc gtctcttttc tattctcatc 1546381 gccgcgatca ggggaaaact ggacggatga tgtcctttat cggaatgaag gaggcataaa 1546441 agatcttgcg tgttgttgat aatttacgac atataaacga acgaataaac gaagcatgta 1546501 acagatcggg ccgcagctcc gatgaagtta cggttattgc agtcacaaaa tatgtatcac 1546561 ctgaaagagc acaggaggca gtagatgctg gcatcacctg cctcggagag aatcgggatg 1546621 cggaactgct ccgcaaacag gaattgatga aagggaatcc ggaatggcat tttatcggca 1546681 gtctgcaatc aagaaaagca aaatctgtcg tcaattcggt ttcctatatc cattccctag 1546741 accggctctc attagcgaaa gaaattgaaa aacgggctga aggtactgta cgatgctttg 1546801 tgcaggtcaa tacctctctt gagccttcta aacatggcat gaaaaaagaa gaagtcattc 1546861 cattcataca ggagctttcc ggtttcgaac atatccttgt tgccgggctg atgacaatgg 1546921 ctccgctgac tgatgatcaa gatcagatca gaagctgttt caggtcgctg agagaactcc 1546981 gtgaccaggt tcagaagctg aaccagccga acgctccgtg tactgaactg tcgatgggca 1547041 tgtcaaatga ttttgaaatt gcaattgaag aaggagctac ttatattaga atcggctcat 1547101 cgttagtcgg aaatgaaaca gggggtgtac agcaatgagt atgaaaaata aactgaaaaa 1547161 ctttttctca atggaagatg aagaatacga atatgaatat attgagacag agcgggaatc 1547221 tcatgaggag catgagcaaa aagaaaagcc ggcttacaac gggaataaac ctgcgggcaa 1547281 acagaatgta gtgagcttgc aaagtgttca gaaatcctct aaagtggtgt tgagtgagcc 1547341 gcgcgtttat gcggaggcgc aggaaatagc cgaccatttg aagaaccggc gggcagttgt 1547401 cgtcaatctt cagcggatac agcatgacca ggcgaagcgg attgttgact ttttaagcgg 1547461 aaccgtttat gccattggcg gcgatattca aagaatcggc tcagatattt tcctctgcac 1547521 gcctgacaac gtagatgtat caggcacaat ttctgagctc atatctgaag acgaacatca 1547581 gaggtggtaa agcgagatga tcctttatca agttttttcg gttttaagct tattaatcac 1547641 aatatactca tttgccctga tcatatatat ttttatgtca tgggtgccga gtacgaggga 1547701 aacagcagtc gggcgttttt tggcttcgat ttgtgaacca tatctcgaac cattcagaaa 1547761 aatcatccct ccgattgcaa tgctggatat ttcaccaatc gtagcaatac ttgtgcttcg 1547821 gtttgcgaca accggcttgt ggggacttta tcgcatgatt gcgttttaat gtgacagttt 1547881 gataggggct tggcagcagc caagcctctt tacatagaag ggaaagacga tgagcgatat 1547941 atatcagcac ttcagaaaag acgagcgggc ctttattgat caagcgctcg aatggaaaag 1548001 aattgtccag gagcagtacc ggatgaagct gaccgacttt ttagatcccc gagagcaggt 1548061 catcctctct gctgttacgg gacaggcaga tgtcgggctt gccttttccg gcggctatga 1548121 cagagcggag cggaaacggg cgattctgtt tccagagtac attactccgg aagaatcaga 1548181 ttttgaactg caggcgttta acgtccgtta tgctgacaag tttgtctcag tagatcatcg 1548241 ttctctgctt ggtgcattaa tgggcatagg attaaagcgg caaaaattcg gtgacatcgt 1548301 gttttctgag acagcagtgc aattgattgt ctcagccgat accgctgatt ttgtggctgc 1548361 acagctgacc caagcaggca aagcggcggt cagcctagag aaaatcgact tgtcagacct 1548421 taacattcca gcagttgatg tcgaaataag agatgacacg gtttcttctt taaggcttga 1548481 cgccgtctgc gcctctatga gcaggcaatc ccgccagaaa tcacagacgc ttgtgaaaaa 1548541 cggccttgtg aaagtgaact ggaaggtggt tgaagatcct tcatacatag tcgcggaagg 1548601 ggacatgctg tctatcagag gttttggccg gtgcagctta acaaaaatcg aaggaaaaac 1548661 caaaaaagac aaatggagag ttacgtttga acgacaaaaa tagtcggttt ttcagttttt 1548721 ttctccatct gtgcgaaatt tgttttataa tgtgaactag ataaccgtac tgaaatgtaa 1548781 aaatggaggt ggcatcatgc cattaacgcc aaatgatatt cacaacaaga cgtttacaaa 1548841 aagttttcgc ggatatgatg aagatgaagt aaatgaattc ctagcccaag tcagaaaaga 1548901 ttacgaaatt gttctccgca agaaaactga gcttgaagcg aaagtcaatg agcttgatga 1548961 aagaatcgga cactttgcca atattgagga gacattgaat aaatcaattt tagttgctca 1549021 agaagcggct gaagacgtaa aacgcaattc tcaaaaagaa gcaaagctga tcgttcggga 1549081 agcggagaaa aacgctgatc gcattatcaa cgaatcgtta tcaaaatcaa gaaaaattgc 1549141 aatggaaatt gaagagctga aaaaacagtc taaagtgttc agaacacgtt tccaaatgct 1549201 gattgaagct cagcttgatc ttctgaaaaa tgacgattgg gatcatctcc ttgagtatga 1549261 agtcgacgct gtatttgagg aaaaggaata aattctctga ttatcttgac attttcttag 1549321 cttgtcgaat ataatacgtt cataaattca gatgaaaaaa cggttgaaag ggacagtcat 1549381 gtttccttca ggccttcata gcgacccgga gatggtgaga gtccgggatg gccggaatca 1549441 tgtagatcag ccctttagtt tccttgctga actcacagta ggttaggacg ttcatcacgt 1549501 tacgatgctc aagaggaaaa agtgtatgct tgctttttct aaaagggtgg taccgcgaga 1549561 taagctttct cgtcccttat gggatgagag ggcttttttt attttctgaa aaaatgcagt 1549621 ggaggaatga aaatggattt taaagacacg ctcttaatgc cgaaaacaga tttcccgatg 1549681 cgtggaaatt tgccaaaccg tgagcctgac attcaaaaaa aatgggagga agaagatatc 1549741 taccgtcttg ttcaggaacg gacgaaagac cgcccgaaat ttgttttaca tgacggacct 1549801 ccgtatgcaa acggcgacat ccatatgggc catgcactta acaagatttt gaaagacttc 1549861 attgtccgct ataaatcaat gagcggctac aacgcaccgt atgtgccggg ctgggataca 1549921 cacggattgc caattgaaac agctctgaca aaaaacaaaa aggtcaaccg caaagaaatg 1549981 tcagtagcgg aattccgcaa actatgcgaa gagtacgctt ggaagcaaat cgagggacag 1550041 cgtgagcaat tcaaacgtct tggtgtccgc ggtgactggg aaaacccata tgtgacatta 1550101 aaaccggaat acgaagcgca gcaaatccgc gtatttggtg aaatggcaaa acgaggctac 1550161 atttacaaag gccttaaacc ggttaactgg tcaccttcaa gtgagtctgc tctggctgaa 1550221 gccgagatcg aatatcaaga taaacgttca gcatctattt acgtcgcttt tggtgtaaaa 1550281 gacggaaaag gcgttcttga aaacggcgag cgcatcatca tttggacaac aacgccgtgg 1550341 acaattccgg cgaacctcgg aatctcagtg caccctgatc ttgagtacag cgtgattgca 1550401 gtaggtgaag accgctttgt tgtagcaagt gccttagtcg aaaatgttgc atcggcatgc 1550461 ggatttgatc agtatgaagt gacaagaacg gtcaaaggga aagaccttga gaacattatc 1550521 gctgaacacc cgctatatgg cagagactct ctcgttatgc ttggtgaaca cgtaacaact 1550581 gatgccggaa caggctgtgt tcatacagcg cctggacatg gggaagatga ctttatcatc 1550641 ggccaaaaat acggtttaga tgtgctttgc ccggtcgatg aaaaaggtgt aatgacaagc 1550701 gaagctcctg gctttgaagg catgttctat gatgatgcaa acaaagcgat cacacagcag 1550761 cttgatgaaa aaggcgcact tgtgaagctt gaattcatta ctcattctta tccgcatgat 1550821 tggagaacaa aaaaaccaac cattttcaga gcaacagcgc aatggtttgc gtctattaaa 1550881 gatttcagat cagacctgct ggatgccatt aaagaaacca aatgggttcc tgaatggggc 1550941 gagcagcgtt tgcacaacat ggttcgggac cgcggagact ggtgtatttc cagacagcgt 1551001 gcgtggggtg tgccgattcc ggtattttac gctgaaaacg gagaaccggt tattacagat 1551061 gaaaccattg aacatgtttc tgaattgttc agacagcatg gatcaaacat ttggtttgaa 1551121 aaagaagcaa aggatcttct tccggaaggc tttacgcatc ctggcagccc gaacggcaca 1551181 tttacaaaag aacaggatat catggatgtt tggtttgatt caggctcttc acatcaagca 1551241 gtgcttgaag aacgtgatga cctcgttcgc ccggctgatc tatacctaga gggatctgac 1551301 caatatcgcg gctggtttaa ctcttctctt tctacagcag tagccgtaac agggaaagcg 1551361 ccgtataaag gtgtgctcag ccatgggttc gcactggatg gagaaggacg taagatgagt 1551421 aaatcaatcg gtaacgttgt tgttccggct aaagtcatga aacagcttgg tgccgacatc 1551481 ttaagattat gggtatcttc agtggattat caggcggacg ttcgcgtgtc tgacgccatt 1551541 ctgaagcagg ttgcggaagt atatcgtaaa atccgcaaca cgttccgttt ccttcacggc 1551601 aaccttttcg attttgatcc aaaaacaaat gcggtggctg tcgaagatct tcgcgaagtg 1551661 gatcagtata tgctgattaa gctgaacaag ctgattgata aagtgaaaaa agcgtatgat 1551721 gagtacgaat ttgcggttgt gtatcacagc attcataatt tctgcacaat cgaattgagc 1551781 tcattctacc ttgattttgc aaaagatatt gtctacatcg agcatgcgga tcatccggat 1551841 agacgcagca tgcagacagt attctacgaa acgcttcttg cattagtgaa gctttcagcg 1551901 cctatccttc cacatacggc agacgaattg tggtctcatt taacatttgt tgaagagcag 1551961 agcgttcagt tgaccgatat gccggaaaca atcacggttc caaacagtga agcgactgaa 1552021 gaaaaatttg accgctttat ggctcttcgt gatgacgtgt taaaagcatt agaaactgcg 1552081 cgaaatgaaa aaattatcgg taaatctttg gaagcaaacc tgaaattgta tccaaacaaa 1552141 gaaaacaagg agctcttggc ttccataaaa gaaaaccttt ctcagctgtt tattgtgtct 1552201 gaactgacaa tcagcgaaga aaatgaagcg ccgaacgatg cgcaaagctt tgcgacgggt 1552261 aaaatcgctg tcgagaaagc ggaaggcgaa atgtgtgaga gatctcgtgt gatttcaaaa 1552321 gatgtagggg caaatccgaa atatcctaca ctttcattac gcaacgctga aatcgttgaa 1552381 aaatactatc aaaaataatg caaaagagcc cggcgtaaaa gccgggcttt ttttgtgcca 1552441 agagtgacat cctttagaac gaaaggaaaa atcttatggg ctttagatca tcattcacag 1552501 gcaacaataa agatactacg ttaagagcag gagttgtgaa gaatgaatga tcaactgacc 1552561 gcaatttata cggaacttct tctgatgaaa gaagaattac agtcgagatt atttgagtat 1552621 tcttgctttc aggtttctac aagcccgcaa gcagcaatca atcaaaaaca aaaagcaact 1552681 ctgatctatc atattaaaga agaacttcaa gacgttctcc ttgcattgtc caaaatcgaa 1552741 aacggcacat tcggatactg tgaagaaact ggggccccca ttcctcttgc aaagctggca 1552801 gtgctgccga cggcccgaac agcaaacgat tttctttatt ctgtccaatt tgagaaaaaa 1552861 acgcttccga tatggaaatc aacggatatc gaatatggtc aggcactgta tgaataacag 1552921 tgtctgtccg gttaatatgc ctgatatttc tttactccag tgctttttat tgataaaatg 1552981 cataatggat taaagtaacc gtaaactgga ggaacgtttg tgctgtatta tatgattgca 1553041 ctacttatta ttgcagccga tcaattgaca aaatggctag ttgttaagaa catggaactt 1553101 ggccaaagca ttccgatcat tgatcaggta ttctatatca cctcccatcg caatacgggt 1553161 gctgcatggg ggatattagc gggtcaaatg tggtttttct acctcataac aaccgctgtt 1553221 attattggta ttgtttatta catacagcgt tatacaaagg gacaaaggct tcttggcgtt 1553281 gccctcggac ttatgcttgg cggtgccatc ggcaacttta tcgatcgggc tgtcagacag 1553341 gaagttgtgg attttatcca tgttattatt gtcaattaca attacccgat atttaacatc 1553401 gcggactctt cactatgtgt cggcgtaatg cttttattta tacaaatgct gttggacagc 1553461 gggaaaaaga aaaaggagca atagcatgaa tcaaattgat ataaccgctt cagaagaaca 1553521 aaaaagtgag cggattgata aatttttggc atcgactgag aatgattggt caagaaccca 1553581 ggttcagcaa tgggtaaaag acggacaggt tgtcgtgaac ggaagcgcgg tgaaagcgaa 1553641 ttataaaatt cagccgggtg atcaggtgac cgtcactgta cctgaaccgg aagcgctcga 1553701 cgtcctggca gagcctatgg atctggatat ttattatgag gaccaggatg tgctggtcgt 1553761 caacaaacct cgcggaatgg ttgttcaccc agcacccggg catcttacgg gcacacttgt 1553821 aaacggtctt atggctcatt gcacagacct ttccggaata aatggtgtga tgcgcccggg 1553881 tattgttcac agaatcgata aggacacgtc cggtttatta atggtggcga aaaatgatat 1553941 ggcgcacgag tcactcgtaa accaattggt caacaaaacg gtcacgcgga aatatacggc 1554001 ggttgtccac gggcttattt ctcatgatga cggcacaatt gacgcgccga tcggacggga 1554061 taaaaaagac cgtcaaagca tgactgtgac acgtgatggc aaaaacgctg tcactcattt 1554121 tcatgtgctt gagcgttttc aggattttac gttagtggag tgccagcttg aaacagggag 1554181 aacccatcaa attcgtgttc atatgaaata tatcggattc ccattagcag gcgatccgaa 1554241 atacggccca agaaaaacaa tcgactttaa tggccaagcg cttcacgcgg gagttttagg 1554301 ttttgaccat ccacgaacag gagaatatgt cgaatttgaa gcgccgcttc ccgaggatat 1554361 ggcagaatta atcgaaaacc tcagaaaaaa cggttgacag agggtttctt ttctgaaata 1554421 ataaacgaag ctgaatagat tctttaaaac agtccagaga ggctgagaag gataacggat 1554481 agacgggatg cgtgtatagg cgcgcacctt gtcctaaaac ccctctatgc tctggcagga 1554541 ggggtttttt cttctatatg aactgtgagg tgtcacacat tgaatcaaaa agctgtcatt 1554601 ctcgacgaac aggcaattag acgggcgctg accaggattg ctcacgaaat gatcgaacgc 1554661 aataaaggaa tgaataactg cattcttgtc ggcattaaga caagagggat ttacctggca 1554721 aaacgccttg cggaacgcat tgaacagatt gagggaaatc ctgttacagt cggtgaaatt 1554781 gatattactc tttacagaga tgatctttct aaaaaaacaa gcaacgatga accgcttgta 1554841 aaaggtgcag atattccggt agatattaca gatcaaaaag tcattctcgt tgatgatgtt 1554901 ctgtataccg gaagaacagt cagagcagga atggatgcgc ttgttgatgt aggcagacct 1554961 tcctccattc agcttgcagt gcttgtggac agaggacacc gggagctgcc gatccgagcg 1555021 gattatatcg ggaaaaacat cccgacatca aagtctgaaa aggttatggt acagcttgat 1555081 gaggtagacc aaaacgatct cgtcgccatt tatgaaaacg aataatagat caccttttta 1555141 agggcaatcc agagaggttg caaagaggtg cacaacaaag gcccaaaaag tattcggcag 1555201 gtctttgtat gcctctttgc gtaaaaaagc aaagaggttt ttttatacag tcattgagtc 1555261 atcctaaaat gaaagtcaac aatcaggggg aaatcatcat gagtaagaaa aaagtaaatt 1555321 taggggtcag ggatgtcccg acacctttct cttgggtttc attcagcctt cagcatttgt 1555381 ttgccatgtt tggctcaacc attttggttc cgaagctcgt cggaatgagt cctgctgtgg 1555441 cgttggtgac aagcggcatc ggaacactgg cgtaccttct tattaccaaa ggacaaattc 1555501 cggcgtatct cggttcatcc ttcgccttta tttctccgat cattctggta aaagcgaccg 1555561 gcgggccggg agcggcaatg gttggagcgt ttcttgcagg gctggtgtac gggctgattg 1555621 ccttattgat taggcagctt ggaacaggat ggctgatgaa gattctcccg cctgtagtcg 1555681 tagggcctgt tattatcgtc atcgggctgg gactggcaag cactgcagta aacatggcga 1555741 tgtatgctga tccgaacgcg agtgagttgg tctacagctt aaagcacttt agtgtcgcag 1555801 gagttacgct ggcaattacg attatttgtg cgattttctt acgagggttt ttaagcctga 1555861 ttccggttct gatcggaatc atcggcggat acctgtttgc ccttactcaa gggattgtca 1555921 acttccagcc ggtgcttgac gcgaaatggt ttgcagtgcc tgaatttatc attccgttca 1555981 aagattattc accgtcagtt acgctcggca tcgcagccgc aatggttcct gtcgcatttg 1556041 tcacaatgtc agagcatatc ggccaccaaa tggtgctgag caaggttgtc ggacaagact 1556101 tcattaaaaa gccaggtctt catcgctcta ttatgggtga cagtgtggcg acaatcctcg 1556161 cttccctgat cggcggccct ccgacaacga cttacggaga aaacattggc gtgctggcca 1556221 tcacaagagt attcagcgtc tttgtcatcg ggggcgcggc agtgattgcc ctttgcttcg 1556281 gctttatcgg caaaatttca gcgctgatca gttcagtgcc gtcagcggtc atgggaggcg 1556341 tctccttcct gctgttcgga atcattgctt caagcggcct gagaatgctg attgacaaca 1556401 aaattgatta tgaaaacaac agaaacctca ttattacatc agttatcctt gtcatcggtg 1556461 taggaggcgc ttttatccaa gtgtctcagg gcggattcca agtgtcagga atggcgcttg 1556521 ccgcaattgt cggtgtcatc ttaaacctga ttcttccgca ggcgaaggaa gagcaggcag 1556581 acacatctga acaacatcat atttaaaacc ttttaatgaa agtccagaga ggcttggaag 1556641 ggttatgaag agaaggaagc ttcaatgctg ccctctattt aaccataccc cgagtctatc 1556701 ttagaccggg gttttttttc agccttaagt tgaaaagaga ggggaaagaa catgaagcat 1556761 ttaacgacga tgagtgaact tagcactgag gaaatcaaag atttgcttca aacagcacaa 1556821 gagctcaaaa gcggaaaaac agacaatcag cttacaggaa agtttgcagc aaacctgttt 1556881 ttcgaaccga gcacgagaac gcggttcagc tttgaggtcg cagaaaaaaa gctgggcatg 1556941 aatgtgctta accttgatgg aacaagcaca agcgtgcaaa aaggcgaaac cttatatgac 1557001 acgatccgga cgcttgaatc aatcggtgtg gacgtctgcg tcatcaggca cagtgaggat 1557061 gagtattatg aagagcttgt cagccaggtg aacattccga ttctgaatgc gggagacggg 1557121 tgcggccagc atccaacaca atcactgctt gatttaatga cgatttatga agagttcaat 1557181 acgtttaaag ggcttaccgt ctccattcac ggcgacatca agcatagcag agtggcaagg 1557241 tcaaatgcgg aagtgttgac aagattgggt gcccgggtcc tattttccgg cccttcggaa 1557301 tggcaggatg aagaaaatac attcggcacg tatgtctcaa tggatgaagc agttgagtct 1557361 tccgatgttg tcatgctgct gcgcattcaa aatgaacgac atcagtccgc tgtcagtcag 1557421 gaaggctatt taaacaaata cggcttgacc gtagaacggg ctgagcgtat gaagcggcat 1557481 gcgatcatca tgcatcctgc tccggtaaac agaggagtgg agattgatga cagcttagta 1557541 gaaagcgaaa aatcaagaat cttcaagcaa atgaaaaatg gcgtatttat cagaatggca 1557601 gtgatacagc gtgccttaca aaccaatgtg aaaagaggag aagcagcgta tgtcatatct 1557661 cattaaaaac ggctggatac taaacgaaaa tggtgaaaaa acacaagcgg atatccgagt 1557721 gactggagaa accatcaccg caatcggcaa gcttgatgca acggataatg aaacggtaat 1557781 tgatgcaaaa ggtttgctcg tttcacctgg gtttgttgat ctccacgtgc atttcagaga 1557841 gccgggcgga gagaaaaaag aaactattga aaccggggca aaagcagcgg cgcgcggcgg 1557901 ctatactaca gtagcagcaa tgccgaatac gcggccggtt cctgatacaa aggagcagat 1557961 ggaatgggtg caaaacagaa ttaaagaaac atcatgcgta agagttcttc catatgcatc 1558021 cattacgatc agacaaatcg gcgatgaaat gacaaacttt gaagcgttaa aagaagccgg 1558081 ggcatttgct tttacagatg acggcgttgg tatacagaca gcaggaatga tgtatgaagc 1558141 gatgaaacgg gcagccgcaa ttgacaaagc gattgttgca cattgcgagg acaactcctt 1558201 aatttacgga gggagcgtac atgaggggac attctccaaa gcgaacgggc taaacggcat 1558261 tccttctgtg tgtgaatcgg ttcatattgc tcgcgatgtg ctgctggctg aggcggcaaa 1558321 ctgccattat catgtatgcc atatcagcac aaaagaatct gtcagagttg tacgcgatgc 1558381 gaaaaaagcg ggaatcagag tgacagcaga agtatcgccg catcatttgc tgctttgtga 1558441 tgaggacatc ccggggctgg acacaaacta taaaatgaat cctccgctcc gcagcccaga 1558501 agacagagct gctttaattg aaggtctttt agacggaaca attgatttta tcgcaacaga 1558561 ccatgcaccg catacggaag aagagaagaa cacagaaatg aagctggcgc cattcggaat 1558621 tgtcggctta gaaacagcat tcccgcttct ttacacacac tttgtcaaaa atggcagctg 1558681 gtcactgaag cagctgattg actacatgac aatcaagcca tgcgaagcgt tcggtctccc 1558741 atatggaaca ttacaaacgg ggcaagctgc ggacattacg ttaatcgatt tagaaaaaga 1558801 agcagttata gacaaagaga catttttatc aaaaggaaaa aatacaccat tcaacggcat 1558861 cagttgcacc ggctggccgg tcgctacaat tgcggcaggg aagcttgctt atgaagaggg 1558921 gagacttgtc aaatgaagag acgattagta ctggaaaacg gagcggtatt cgagggagaa 1558981 gctttcggaa gcttagaaca caacatggga gaagtcgttt ttaatactgg gatgacaggc 1559041 tatcaggaaa ttttatctga tccttcttac tgcggacaga tcgtaacatt aacatacccg 1559101 cttatcggaa attacggcat taaccgtgat gattttgaat ccattacccc ttttgtcaaa 1559161 gggctgatca tcaaagaatt atgtgagctg ccttccaact ggcgttcagc atacacctta 1559221 gacgagtatt taaaaatgaa aaacattccc ggactccagg gaattgatac aaggaagctg 1559281 acaagaatga tccgcacggc aggcgcgcta aaaggaacat tcgcttcatc tgatgaagat 1559341 atcgaagcag tgctgaaaag actgaacgaa acggaattgc caagaaatca agtatcccaa 1559401 gtatcagcaa aaacagcata tccgagcccg ggaagaggca aacgcattgt cttggttgac 1559461 ttcggcatga aacacgggat tctaagagag ctgaacaaac ggaaatgtga cgtcatcgtt 1559521 gtgccttaca acattacagc ggaagaggtg cttcagctga aaccggacgg tatcatgctt 1559581 tctaacggac ctggagaccc gaaggatgtg cctgaagcga ttgaaatgat taaaggtgtt 1559641 cttggaaaag tgccattatt cggaatatgt ctcggccacc aattattcgc gctggcgtgc 1559701 ggggcgaata ctgaaaaaat gaaattcggc cacaggggct caaaccaccc ggtaaaagag 1559761 ctggctacag gaaaagttgc cttaacatct caaaaccatg gatatacagt ttcgtctatc 1559821 agtaaaacag aactggaagt gacgcatatc gcaattaacg acgatacgat tgaagggctg 1559881 aagcataaaa cattgccggc atttacggtt caatatcatc ccgaagcctc acctggtcct 1559941 gaggatgcca accatctatt tgacagattc atcgaaatga tcgaaacaac agagaaagaa 1560001 ggggaagcgg tatgccaaaa cgcgtagaca ttaacaaaat tttagtaatc ggatctggac 1560061 cgatcatcat cggccaagca gcagaatttg actatgcggg aacacaagcc tgtcttgctt 1560121 tgaaagaaga aggctatgaa gtcatccttg tcaactcaaa ccctgcaacg atcatgacag 1560181 atacagaaat ggctgaccgg gtttacatcg aaccgctcac acctgaattc ctgacacgaa 1560241 tcatcagaaa agagcgcccg gatgccattc ttcctacact cggaggccaa accggtttga 1560301 atcttgcggt tgagctttct gaaagaggcg ttttggcaga atgcggcgtc gaagtgcttg 1560361 gcacgaaact gtctgcgatt cagcaagctg aagaccgtga cttgttcaga acattaatga 1560421 atgaactgaa tgaaccggtg cctgaaagtg agattatcca ctcccttgaa gaagcagaaa 1560481 aattcgtcag tcaaattgga ttccctgtca ttgtccgccc ggcatataca ttaggcggaa 1560541 caggcggagg catctgctcg aatgaaacag agctaaaaga aatcgttgag aacggcttga 1560601 aattaagccc ggtacaccaa tgtctgcttg aaaaaagcat cgccggctat aaagaaatcg 1560661 agtatgaagt catgagagac agccaggatc acgccattgt cgtttgtaac atggaaaaca 1560721 ttgatccagt tggaatccat actggagaca gtattgttgt cgcgccgagc caaacgctca 1560781 gcgatcgcga atatcagctc ttgcggaatg tatcgttaaa actgattcgc gcgcttggga 1560841 tcgaaggcgg atgtaatgtc cagctcgcct tagatccaga cagcttccaa tattacatta 1560901 ttgaagtaaa tccgcgtgtc agccgttcat ctgcccttgc atcaaaagca acggggtacc 1560961 cgattgcaaa gctcgctgct aaaattgcag tcggactttc attagatgaa atgatgaacc 1561021 cggtgacagg aaaaacatat gcagcatttg aacctgctct tgactatgtc gtatccaaaa 1561081 ttccgcgctg gccgtttgat aagtttgaat cagcaaacag aaagcttggc acgcaaatga 1561141 aagcgacagg tgaggtcatg gcaatcggcc gcacgcttga agagtcattg ctgaaggcag 1561201 tgcgatcact ggaagcggat gtgtatcatc ttgaattgaa ggacgccgct gacatttcag 1561261 atgagcttct tgaaaagcga attaaaaagg ccggtgatga acgcttattc tacttagctg 1561321 aagcgtacag aagaggctac acggtagaag acctccatga attttccgct atcgatgtct 1561381 tcttcttgca taagctgttc ggaatcgtac agtttgaaaa agaattgaag gccaatgcgg 1561441 gcgatacaga tgtgctgaga cgggcaaaag aactcggctt ctctgatcag tacatcagcc 1561501 gtgaatggaa aatgaaagaa tctgagcttt acagcttgag aaaacaagcg gggattgcgc 1561561 cggtattcaa aatggtagat acatgcgcgg cggaatttga gtcagaaacg ccatacttct 1561621 atagcacata tgaagaagaa aatgaatctg tcgttacaga taagaaaagt gtgatggtgc 1561681 ttggttcggg tccgattcga atcggtcagg gtgtcgagtt cgactatgcg acggttcact 1561741 ctgtatgggc aattaaacaa gcaggctatg aagccattat tgtcaacaac aacccggaaa 1561801 ccgtttcaac agacttcagc atctcagaca agctgtattt tgaaccgctt acgattgaag 1561861 atgtcatgca catcattgac ctcgaacagc caatgggcgt tgtcgtacaa tttggcggac 1561921 aaactgcgat taaccttgct gacgagcttt ctgcacgcgg agtgaaaatc cttggaactt 1561981 cattagaaga tttagaccgt gccgaagacc gggataaatt tgaacaagcg cttggagaac 1562041 ttggtgttcc tcagccgctt ggcaaaacag cgacatcagt taatcaggcg gtaagcatcg 1562101 caagtgatat cggttatccg gtactggtac gcccttccta tgtacttggc ggccgggcga 1562161 tggagattgt ttaccatgaa gaggaactgc ttcattacat gaaaaatgca gtcaaaatca 1562221 atccacagca ccctgtatta attgatagat acttgaccgg aaaagaaatt gaagtcgatg 1562281 cagtatccga cggtgaaaca gtcgtcattc cgggaattat ggagcacatt gaacgtgcgg 1562341 gcgttcactc cggagactca atcgctgttt atccgcctca gtctctcaca gaggacatta 1562401 agaaaaaaat tgaacaatac acgatcgcat tggctaaagg gctgaatatt gtcggtttgc 1562461 tcaatattca attcgtcttg tcgcaaggcg aggtgtacgt gctagaagtg aatccgagat 1562521 caagcagaac cgtaccgttt ttaagcaaaa ttacgggtat cccaatggcg aatctcgcaa 1562581 caaaaatcat tcttggtcaa aagctggctg cgtttggcta tacagagggc cttcagcctg 1562641 aacagcaagg tgtatttgta aaagcgccgg tcttctcctt tgccaagctg agaagagtgg 1562701 atattacgtt agggcctgaa atgaaatcaa caggtgaagt catggggaaa gattcgacac 1562761 ttgaaaaggc gctctacaaa gccttgatcg cttcaggtat tcaaatcccg aactacggtt 1562821 ccgtgctttt aacagtagct gataaggaca aagaagaagg gcttgccatt gctaagcggt 1562881 tccacgcgat cggctacaac attttagcga cggaaggaac ggcaggctac ctgaaagaag 1562941 cttccattcc agcgaaggtc gtcggaaaaa tcggtcagga tggcccgaac ttgcttgatg 1563001 tcatcagaaa cggagaagcg cagtttgtca tcaatacgct gacaaaagga aagcagccgg 1563061 caagagacgg ttttagaatc agacgtgaat cagtagaaaa tggtgttgcc tgcctaacat 1563121 ctttagatac ggcagaggcg atattgcgag tgctggaaag catgacattc cgtgctgatc 1563181 aaatgccggc agtcaacaca aatcaggagg cggcagtcac tatatgaaaa aagcgtattt 1563241 gacagtatgt tctaaccagc aaattgcaga ccgggtgttt caaatggttc tgaaagggga 1563301 gcttgtccaa gggtttacaa cccctggaca gttccttcat cttaaagtga gcgaagcggt 1563361 tacgcctctt ttgagaaggc cgatcagcat cgcagacgtc aactttgaaa aaaatgaagt 1563421 caccatcatt tatcgggtag atggggaagg gacaagactc ttgtcactga agcagcaggg 1563481 agaacttgtg gatgtcctcg ggcctttggg aaatggcttt cctgttaatg aagttcaacc 1563541 cggaaagacg gctttgctgg taggaggcgg agtaggtgtg ccgcctctcc aagagctgtc 1563601 gaaacgcttg attgaaaaag gggtaaatgt catccacgtt ttaggattcc aatcggcaaa 1563661 ggatgttttt tacgaggaag aatgccggca gtacggagac acgtatgtgg caacagctga 1563721 cggaagctac ggggaaaccg gatttgtcac agatgtgatt aaacggaaaa agctagagtt 1563781 tgatatcctc ctcagctgcg ggccgacacc gatgctcaag gcgttaaaac aggaatatgc 1563841 ccataaagaa gtatatctgt ccatggagga acgaatgggc tgcggaatcg gcgcatgctt 1563901 cgcgtgtgtg tgccatacaa acgaaagtga gacatcctat gtaaaagtat gtctcgacgg 1563961 gcctgtattt aaagctcagg aggtggcgct gtaatgctag aggtgaaatt gccgggactt 1564021 gatttgaaaa acccaatcat tcctgcatca ggctgcttcg gttttggaaa agaattttca 1564081 cgtttttatg atttgtcttg tcttggagct atcatgatta aggctacgac aaaggagccg 1564141 cgctttggga atccgacgcc gcgggtagct gagactggtg ctggaatgct caatgcgatc 1564201 ggtctccaaa atccggggct ggatagtgtg ttgcatcatg agctgccgtg gcttgagcag 1564261 tttgatacac cgatcattgc caatgtcgca ggttctcaag tcgatgatta tgttgaagtc 1564321 gcagaacata tcagcaaagc gcctaatgtt catgctcttg aattgaatat ttcctgcccg 1564381 aatgtgaaaa caggcggaat cgcttttggc acgaatcctg aaatggctgc cgatttgaca 1564441 aaagcggtga aagaggtttc ggatgtaccc gtttatgtga agctatcccc gaacgtggct 1564501 aatatcacag aaattgcatt agcgatcgag gaagcgggag cggacggtct tacgatgatc 1564561 aacacactaa tcggcatgag actcgattta aaaaccggca aaccgatatt agcgaataaa 1564621 acagggggac tttcgggccc tgctgtgaag ccggttgcca ttcgcatggt gtatgaagtc 1564681 agccagatgg tcaacatccc gattatcgga atgggaggcg tgcaaacggc tgaagatgcc 1564741 ctggaatttc ttctcgcggg agcaagcgca gtcgctgtcg gaacagcaaa ctttgtgaat 1564801 ccttttgcat gtccagagat tattgaacag ctcccatctg ttttgctcca atacggctat 1564861 caatcaattg aagaatgcat cggaaggagc tggaatcatg aaaaacaacc tgcccatcat 1564921 cgcgcttgat tttgcgtcag ctgaagaaac acttgcgttc ttagcgcctt ttcagcaaga 1564981 accgttattt gtaaaggttg ggatggagct tttttatcaa gaagggccat ctatcgtgaa 1565041 acaactaaaa gaaagaaact gcgagctatt tttagatcta aagcttcatg acatcccgac 1565101 tactgtaaac aaagcgatga agcgccttgc cagtcttgga gtagacctcg tcaatgttca 1565161 tgctgccggg ggcaaaaaaa tgatgcaggc agctctcgaa ggcttagaag aaggtacgcc 1565221 ggctggaaaa aaacgtccgt cacttatcgc ggtaacccag ctgacaagca catctgaaca 1565281 aatcatgaaa gatgaactgc tgatcgaaaa gtctctgatt gatacggttg tgcactacag 1565341 caaacaggcg gaagaaagcg gactggatgg agtggtctgc tctgttcatg aagcaaaagc 1565401 catttaccaa gcggtgtcgc cttcatttct gactgtcact ccggggatca gaatgtcaga 1565461 ggacgctgcg aatgaccaag ttcgcgtagc gacgcctgcc attgcaagag agaaaggttc 1565521 atcagcgatt gtagtaggac gctcgattac aaaagcggaa gacccggtaa aagcctataa 1565581 ggctgtcaga cttgaatggg agggaatcaa atcttgaaac aaatcatcgc aaaacatcta 1565641 ttagacatcc aagctgtatt tttacgcccg aacgagccgt tcacatgggc aagcggcatt 1565701 ttatcaccga tctactgtga caaccgcctt acgctatctt tcccagaggt cagaaacgat 1565761 gttgcttcag gtatcagcaa gcttgttaaa gagcattttc ctgaagctga aatgattgcg 1565821 ggaacagcaa ctgccggtat tcctcatgct gctcttgcgg cggaccattt gaatcttccg 1565881 atgtgttatg tgaggagcaa gccgaaggcg cacggaaaag gcaatcagat tgagggagct 1565941 gtgcaagaag ggcaaaaaac agtcgtcatt gaagacttaa tttccacagg aggcagcgtg 1566001 cttgaagctt gtgcagcttt acaagcggcc ggctgtgaag tgcttggtgt cgtctcaatc 1566061 tttacgtacg gacttcctaa agcggaggaa gccttcgcaa aggcagaact gccatactac 1566121 tcattaaccg attatgatac gctcacagag gtcgcgcttg aaaacggaaa tattcattca 1566181 gatgatctaa aaaagctgca aacatggaaa cgaaatcccg agtcaaaaga ttggtttaaa 1566241 aaataaaaaa taaattcaaa tgatgtaaag aggcttcaaa gccttgctgt acttgaaaac 1566301 aggctgtgag gcctgttttt ttattaatcc tataaaaaaa gtcgggttga cttatgttag 1566361 aattgtgcta aaatttacta caaatctaaa aacttatcaa gagcggctga gggactggac 1566421 ctatgaagcc cggcaacctg catagtttgt aaggtgctac ttccagcaaa atgaattcca 1566481 ttttgaaaga taagggctgc atgctgttcc tgtctttctt tccgccggat tgaaagtttt 1566541 ttattttaag aggtaaaaag gctatctgta tatcagcagc cgcgaatcac attacatggg 1566601 aaaagacaac cggcagaaag ctactgtttg tttgtctccg aaaggaggaa agaagaaatg 1566661 ttaacgtatg ataattggga agaaccaacg attacatttc cggaagacga tccttataaa 1566721 ggagcgctgt cagttttaaa atgggcatac ggccattacg gcgatcagct tgtttatgcc 1566781 tgcagtttcg gaattgaggg aatcgttctg attgacttaa tttataaagt gaaaaaagac 1566841 gcagagattg tgtttcttga tacaggactt cattttaaag aaacctatga aacaattgaa 1566901 cgagtgaaag agcgttatcc gggtcttaat atcatcctga aaaaaccaga tctcaccctt 1566961 gaggaacaag ccgaagaaca tggtgacaaa ctatgggaaa gagagccgaa tcagtgctgc 1567021 tatcttagaa aggtcgttcc tttaagagag gcgctttcag gacatccagc ctggctttcc 1567081 ggcctgcgcc gtgatcaagg gccaagccgt gccaatacga atttcttaaa caaagatgaa 1567141 aaattcaagt cagtaaaagt ttgcccgctt atccattgga cttggaaaga catttggaga 1567201 tatacatccc ggaatgaact ggactacaat ccgcttcatg accaaggcta tccaagtatt 1567261 ggctgtgcgc cttgcacttc tcccgctttt acagcagaag atttgcgctc aggcagatgg 1567321 aatggtatgg cgaaaacaga atgcggactg catgaataag gagctgcaaa atggaattag 1567381 ccgctatttt atttagcttg tttttcgcga tgaatattgg tgcaagcggc gctgcagctt 1567441 cgatgggggt tgcttacggc tccggagcca tcaaaaagaa aacttacgct ttgatcctat 1567501 gcgcagtcgg tgtctttgcc ggggcggtca ttggcggagg cgaggttgta aaaacaatca 1567561 gctccggcat tattcctgag cagacgatta cactgacgat tgtttgcatc attattggag 1567621 ctgctgccct gtcgctcttt actgctaatc tgctcggcat tcctttgtcg acaagtgaag 1567681 taacagtcgg cgcggttgtc ggcgtgggag tggcttataa agtattgttt gtgaacaatc 1567741 ttctgatcat tgtgtcattt tgggtttttg tcccgctgtt cgctttcggc ttcacctatt 1567801 tcgtatctaa gctgtttcgt tattttaaga ttgaagtaaa atcttctaaa aagcaaaaaa 1567861 tcctcggcat tgttttgtta gttgccggat ttttcgaagc attctctgcc ggcatgaata 1567921 acgtggcgaa tgctgttggc ccgttagtag ctgccggtgt gcttgatgtc ggaaaaggaa 1567981 ccttgtatgg aggagctttt gttgctcttg gcgcactgtt attaggccgg cgagtgctag 1568041 aaacaaacgg gaagaaaatt acgaggttct ccaaagggga aggcattctc ttatccggta 1568101 caggagcggg actggtgatc atcagttctg tatttgggat gccggtgccc ttggcgcaag 1568161 tcacgtcatc gtctattatc ggaataggca tggcgaaaaa cggtccgaac gtgttccata 1568221 aacaagttgt tcaaacgatg ctgaaggtat ggatcgtatc gccgttttta tctttatcga 1568281 tttcttatct gcttgtatcc ttgtttttaa aagcagatta ttattcgatc tttatcatgg 1568341 taagtgtgct tttagcggcg ggcggtgcca tcagcctgac aaaggccatt cgtaaagaga 1568401 gacgctcagt ccacgaacaa ggcgggggaa tctgatcatt aatctgagta attttataag 1568461 ttaactagga ggagatggat attatgagct tagcaccaca cggaggaaca ttagtaaaca 1568521 gagtagatga atcatatgat gtgagcggca ttcaaaaaga aattgaactt gatttaattt 1568581 ctttcgcgga tttggaattg atcggtatcg gtgcatacag cccgattgaa ggtttcttta 1568641 atgaaaaaga ttacgtatca gtggtcgaaa acatgcgtct ttcttccggc gttgtctggt 1568701 ctcttccaat cacgcttccg gtcgatgcgc aaaaagcagc ggaactgtca cttggtgaaa 1568761 cggtaaagtt aacgtatgaa ggagaaactt acggcgttat ccaaatcgaa gacctgtacg 1568821 tgcctgacaa acaaaaagaa gctgtcaatg tgtacaaaac agatgaacag gagcatcctg 1568881 gtgttaaaaa gctgttcagc cgcggcaata catatgtcgg cggaccgatt acgttgatta 1568941 aaaaagcttc aaaacagttc cctgaattta catttgaacc gtcagaaacg agacgccagt 1569001 ttgcggaaaa aggctgggaa accattgtcg gtttccaaac aagaaaccct gttcacagag 1569061 cgcatgaata cattcaaaaa acggctcttg aaacagtaga cggcttgttc ttgaatccgt 1569121 tagtaggtga aacaaaatct gatgacattc cagctgatgt acggatggaa agctaccaag 1569181 tgcttcttga tcattattac ccgaaagatc gtgttttcct tggtgtcttt ttagcggcga 1569241 tgcgttatgc aggcccgaga gaagcaattt tccacgcgct tgtcagaaag aactacggct 1569301 gcacacattt catcgtcggc cgtgatcatg caggtgtagg cgactattac ggaacatacg 1569361 aagcacagga actgtttgac acatttaaac ctgaagaact cggaattaca ccgctgaaat 1569421 ttgagcacag cttcttctgt aaaaaatgcg gaaatatggg aacagcaaaa acttgccctc 1569481 atggcagaga gcatcacgtc attttatcag gcactaaggt aagaggtatg ctgagagacg 1569541 gtgtgctgcc gcctgctgaa ttcagtcgaa aagaagtagt agaagtgtta atcaaaggga 1569601 tgaagaaaaa agaagaagta ggcgtatctt aaggaggact ggcagtgaca aatcgcgata 1569661 ttgtatggca tgaagcctct atcacaaaag aagagtatca gcaaaaaaac aagcataaaa 1569721 gctccattct ctggctgaca gggttaagcg gctcaggcaa atcaaccatt gccaacgccg 1569781 ctgcgagaga attgtttgag caaggctacc aagtcattgt gctggacggg gataatatcc 1569841 gtcacggcct aaatagggat cttggttttt ctgatgaaga ccgaaaagaa aacatccgcc 1569901 ggatcggaga ggtggcgaag ctttttgttc agcagggaac cattgtgatt actgctttta 1569961 tctctccttt ccgcgaggac agacaacagg ttcgcgagct tgtggaagcg ggcgaattta 1570021 atgaagtcta cattaaatgc gaccttgata tttgtgaaca aagagatccg aaagggcttt 1570081 acaaaaaagc aagaaacggc gagattccgt tctttacagg aattgattct ccttatgaag 1570141 aaccggaagc tccagagctc gttcttgatt caggacagca tgaccgtgaa gcgtgtaaaa 1570201 atcagctgat cgagtttgtt aaacaaaaat tgagctgaat atgatctgct gcgttcttct 1570261 cagatgccgg aatgcaagcg agaacatcat cacagcgaat cttctggaag aactcgaata 1570321 gatcggggga aatacgatgg ggaaagtata tattgtagga gcgggtcccg gtgaccctga 1570381 tctgctgaca attaaagcgc tgaaagccat tgaaaaagct gatgtcatct tatatgacag 1570441 attagtaaat aaagagattt tacaatatgc caaagagcaa gcagacctga tctactgcgg 1570501 gaagcttccg gattttcata cgatgaagca ggaaaccatc aatcgatttc ttgtgaagta 1570561 tgcgcaaaaa gggaaaatgg ttgtcagact gaaaggcgga gacccttttg tgttcgggag 1570621 aggaggggaa gaagcggaat gcctctctga aaatggaatt ccgtttgaaa tcattcccgg 1570681 cattacgtct ggaatcgcgg cagccgctta tgccgggatt cctgttaccc atcgggatgc 1570741 gggctctaac gtcgcttttg taacgggtca ctataaaaaa gaagaagatt ttgaggaaaa 1570801 gtggaaagcg ctggctacag gaattgatac acttgtcatc tatatgggta tcaaaaacgt 1570861 gcagcagatt gaaagaaaac tccttgaaaa tggccgggac ggttctacgc cagcagcctt 1570921 tattcattgg gggacaacgg acaagcaaaa atctgttttt tgtacagttg acaccctttc 1570981 agaaacggtg ataaaagaaa acattacaaa tccgagttta attgtcattg gaaatgttgt 1571041 aaattatcac tataagctgg aatggtttga atctgaacta aaaaaacaag atttaagcga 1571101 ggcgttgtaa aaatgaaaca agcaatttta tatgtcggcc acggcagccg ggtcaaaaaa 1571161 gcgcagcaag aagccgcagc ctttttggaa ggatgcaagg cccacatctc tgtgccagta 1571221 caagaaatca gctttttaga gcttcaggag ccgacaattg agacaggatt tgaagcatgt 1571281 gtgaagcaag gtgccactca tatcgcagtg gtgcctctgc ttcttttaac agctgcgcat 1571341 gcaaaacatg atattccgga agaaattgtc cgtgttgcat ctcgatatcc atcagtccgt 1571401 atttcatacg gaaagccgat cgggattgac gaagaagtag tcaaggctgt atatcaccga 1571461 atgaaagaca taggtgttcc gtatgaaaat gccagagtgg tgctcatcgg aaggggaagt 1571521 tcagatccag acgtcaaaag agacgtaacc ggaattgcta atcttcttca ggaaatggtt 1571581 ccagtgaagg aagtcattcc gtgctttttg acagcatgcg gccctaatta caaagaggtt 1571641 ttttcagaac ttgaaaaaga tgacggcata acaaccttta tcgttccata tttgcttttt 1571701 acgggtatgc tgatgaatga aatcgaacga gaggttcaga aattaaaagc ccataatccg 1571761 aacgtctacc tctcttccta tatcggtttt catcctcatg tgaaaaacgc atttttgaac 1571821 cgtgtgagag aaactgcggc aaattctgag ggacaatttg attttgatgg aggttcatat 1571881 gcttccgctg cacattagcc tggaaaagaa gaaggttgtg attgcggggg gcggaagcat 1571941 cgctctcaga aggctgaaaa cggtgatttc tgagggagct gatataacgc ttgtcagtcc 1572001 ggatgtggaa ccggaaatca agcaaatggc agaagagcgg cgtatcaaat gggaaaaacg 1572061 gacaattgaa aaagaagatt atctcaatgc tttcttcatt attgctgcga cggataatgc 1572121 ggcagtgaac aaagaaattg cccaatccgc ttcgcctttt cagcttgtca attgtgtcag 1572181 tgacgctgag cttggcaatg tatatatgcc gaaaatcgta aaaagagggc atgtcactgt 1572241 gtctgtttct acaagcggag ccagtccaaa gcacacgaaa gagcttgctg aaaacgtgga 1572301 taagctgatt gacggcgatt ttgttgctga agtgaacagg ctttatcaga tgagaagaaa 1572361 gaaataagcc agagcataca aatgctctgg cttttcttta tgcggctcag ctttttttga 1572421 gcttgatgac agtatcagca tcaggcgtga caaagacggt atgctggctg tcataagtga 1572481 cgaaaccggg tttcgcgccg tttggttttt tgacatgcct gatttttgta taatctacag 1572541 gcactgaact tgaatcttta gcttttgaaa aataagctgc aattgtcgcg gcttccatga 1572601 ttgtttgctc atcaggttcg ctgcttctga tcacaacgtg ggagccggga atgtccttcg 1572661 tgtgaagcca gatatcgtct ctggccgcca ctcttgtcgt taaatattca ttttgacgat 1572721 tgttcttacc cactaaaatt gtcagccctg aggtggattc atatgtttct aacaccggat 1572781 tgtgcggttt ttgctttttc tggccttttt gctgcttagg gcgtaaatat ttgccctcaa 1572841 caagctcttc cctgatttcg ctgatatccc ggggagaagc ggacgaaagc tgctgaatca 1572901 gctgatcaaa atattcgatc tcttcctgtg ccagcctgat ttgctcctcg acaactgcga 1572961 ccgaattttt cgctttctga tacttcgtga aataggcctg tgcgttttca gaaggcgttt 1573021 tgttcgggtt taaaggaatc gtgattgtcg ggctttcttc atcataataa ttgatgacct 1573081 cagcctgttt atcacctttt ttcagcatat ataaattagc ggttaaaagc tctccgtaaa 1573141 gctgaaattc cttcgcgttt tccgaatact ccagggtttt ctctaatttt ttgattttgt 1573201 tggcattctt cttccgttcg ttcacaacaa aacgctcaag atcctgagcc tgttgcttaa 1573261 cccggtctcg ttcagctttt ccgaaataaa aacggtcgag cagttcgctt aatgaatcaa 1573321 aacggcgcgc ttcgcccttt agatgagtca gctccagcag ataaaaatat tcctttccgt 1573381 ttacagtcgt aatgttggga atgaaacggt gctctttcac ttcggcaaac agtgccagca 1573441 acgcttttgg cagtgtgact ttgttggcaa ggcctgctct gtgaaccgct tctttggcga 1573501 aaagcggaga cacgcctgaa aagtggtcga caatttgttt atcaagcctt ccttcttgaa 1573561 agctgaggtg acgcaaaata tcatcttctg acgcctcaag aggcgatatt ttgtcctgag 1573621 caggcggaag cttataatct tggccgggca gtactgtacg gtagctgttc attgacggtg 1573681 ataaatgctt aagtccgtcg ataatcacat tttctgctgc gtcagtcaaa atgatattgc 1573741 tgtggcggcc cataatttct acataaagct ttcgtacggt ttcatcgcca atttcgtttc 1573801 ggcttttgat atgaaaaatc ataatgcggt ctaagcccgc ttgttcaatt ttctcaatga 1573861 atccgccttc gatatgcttt ctcagcaaca tgcaaaacat tggcggttcg cttggatttt 1573921 cataagcttg tgccgtgata tgcacccgtg aatagctcgg atgtgccgat aataatagtt 1573981 tttggttttt tcccttggca cggatgtgga aaatcacatc gtgcttatat ggctgatgga 1574041 tttttgtaat tcgtccgccc attattttct cgttaagttc gtgtgtcatt ccgtatgtaa 1574101 acatgccatc aaacgacata tgcaatacac cctctcattc ttcctgcatt cgataattat 1574161 agcatgaaat gggacgagtc agaataagca tgcttataga gtgatatctc tataagagag 1574221 caggggagtg gacgagcgga atgaagtttc atgaaatggg acaaacagat ttactagagg 1574281 caaccaatac gtccatgaaa caaggattaa cagaaaaaga ggtaaaaaaa cgccttgaca 1574341 agcatggacc aaacgagctg caagaaggga aaaaaacttc agcgcttctc ttgtttttcg 1574401 cgcagttcaa agattttatg gtgcttgtgc ttctggcggc aacgttaatc tcaggatttc 1574461 ttggtgaata tgtagatgcg gttgcgatta ttgcgattgt gtttgtgaat ggcatactcg 1574521 gtttctttca agaaaggcgt gctgagcaat ctcttcaggc tttaaaagag ctttcaacac 1574581 cgcacgtcat ggcactcagg gaaggaagct ggacaaagat tccttctaag gaactggtgc 1574641 cgggtgatat tgtgaaattt acgagcgggg acagaattgg cgcagacgtt cgaattgttg 1574701 aagcgagaag ccttgaaata gaagaatcag cgctaaccgg ggaatcaatc ccggttgtga 1574761 agcatgctga taaattgaaa aaaccggatg tttcactcgg cgatattacc aatatggcat 1574821 ttatgggtac gattgtgacc cgcggcagcg gtgtcggggt tgtcgtcggg acaggaatga 1574881 atacggctat ggggaaaatt gccgacatgc ttgaatcggc agggacattg tcaaccccgc 1574941 tgcaaagaag actggagcag ctcgggaaga ttttgattgt tgttgcattg cttctgaccg 1575001 tacttgtcgt tgctgtcggt gttattcagg gtcatgatct gtacagtatg tttttagcag 1575061 gtgtctcgtt agcggtagcc gctattccgg aggggctgcc ggcgattgtg acagtggcgc 1575121 tttcgcttgg tgtacagagg atgattaaac aaaaatccat tgttagaaag cttcctgctg 1575181 ttgaaacgct tgggtgtgcg tctatcattt gctcagataa aacagggaca atgacccaaa 1575241 acaaaatgac agtgacgcat gtctggtccg gagggaaaac atggagagtg gcaggggccg 1575301 gctatgaacc gaaaggaagc ttcacactaa acgaaaaaga gatcagtgtc aatgaacata 1575361 agccgcttca gcagatgctt ctgttcggag cgctttgtaa caactccaat attgagaaaa 1575421 gagacggcga atatgtgctt gacggagatc cgacagaggg agcgctgctc accgcggcaa 1575481 gaaaaggcgg tttttcaaag gagtttgttg aatctaatta cagagtgatt gaagaatttc 1575541 cgtttgattc cgcacggaaa atgatgactg tcatcgtaga gaatcaagac agaaagcgct 1575601 atatcattac aaaaggtgcg ccggatgtac tcatgcagcg atcttcccgt atttattatg 1575661 atggctcagc ggctcttttt tcaaatgaaa gaaaagcaga aacagaggcg gtattaagac 1575721 atttggcatc acaggcgctc agaacgatag cggtcgccta caggccgata aaagcaggcg 1575781 aaacaccgtc aatggagcag gcggaaaaag atctgaccat gcttggcctt tcaggtatca 1575841 ttgatccccc gcggccggaa gtcagacagg cgattaaaga atgccgtgaa gcgggaatta 1575901 agaccgtcat gattacaggt gatcatgtag aaaccgctaa agcgatagcg aaagacttgc 1575961 gcctccttcc gaaaagcggc aaaatcatgg acggcaagat gctgaatgaa ctttctcaag 1576021 aagagctttc tcatgtggtg gaggatgtgt atgtatttgc ccgcgtttcc cctgaacata 1576081 aactaaaaat cgtaaaagcc tatcaggaga acgggcatat tgtggcgatg acgggagacg 1576141 gcgtcaatga tgctcctgcc attaaacagg ctgatatcgg cgtctctatg ggcattaccg 1576201 ggacagatgt ggccaaagaa gcatcatctc ttgttctcgt ggatgataat tttgcgacga 1576261 ttaaatcagc gataaaagaa ggcaggaaca tctacgaaaa tatcaggaag tttatcagat 1576321 acctgttggc gtctaacgtc ggagaaatcc ttgtcatgct gtttgcgatg ctgcttgccc 1576381 ttcctttacc gctggttccg attcagattt tgtgggtcaa cttggtgacg gacggattgc 1576441 cggcaatggc gctcggcatg gatcagccgg aaggagacgt catgaagcgc aagccccgtc 1576501 atccgaaaga aggggtattt gcccgcaagc taggatggaa ggtcgtttcc agaggatttt 1576561 taatcggagt tgccactatt ttagcgttta tcattgtgta ccaccgcaat ccggaaaact 1576621 tggcttatgc ccagacgatc gcgtttgcca cattggtgct cgctcagctt attcacgtgt 1576681 ttgactgccg cagcgaaact tctgttttct ctagaaatcc gtttcaaaac ctgtatttaa 1576741 tcggcgcggt attgtcatcc attttgctga tgcttgtagt aatctactat ccgccgcttc 1576801 agccgatttt ccatactgta gccatcacgc cgggggactg gatgctcgtc atcggtatgt 1576861 ccgccatccc tacttttttg ctggcggggt cacttttaac aagaaaaaaa taaattcata 1576921 tgatataatc ttaggggtaa tagcgtgtct attgcccttt tattatgaga acagggaaga 1576981 attgggtgtt ttaaaatgat acgaagtatg acaggcttcg gcagtgcaag caaaacacaa 1577041 gacgatctct ctgtaagcgt tgaacttaaa tctgtgaact acagatttaa agaagtgaac 1577101 gctcgtttgc caaggccttt gctatatttt gaagataagc tgaaacagac cattctgcag 1577161 catattcagc gcggaagaat tgagcttttc gtatccgttg acagcgatat gcttgttgag 1577221 aaaaggcttg aaattgattg gccgctgctc gatgagtttg tcgcagccgc gagagatatg 1577281 aagaagcggt atcaattgtc tgcagagccc gatgtaatgg atttctttaa gcttgatcat 1577341 gtcgtccagg ttcatgaaga acagacgcaa aatgacaagc tggaggcgtt gatcatcgat 1577401 gctgcagaag aagcggtaaa aggtctctgt gaaatgcgtg aaaaagaggg gctgctctta 1577461 gcgaaagact gcctgatgca tattgatcag cttgaagagc tggtgagaga aactgaattg 1577521 ctggctgcag atgtcgtatc tcgttaccgg gaacggctgt atgccagaat caaagaatgg 1577581 actgaagacg tattagacga gagccggctt gtaacagaat gcgctatttt tgcagaccgc 1577641 tctgatatca ctgaagagat tacaaggctg aagagccact tcgcccagtt tcgtgatata 1577701 ttagctagtg gcggagctgt cgggcgcaaa ctcgactttc ttgttcagga gctcaatcgg 1577761 gaagcaaata cgatcggctc aaaagcaaat gatcatcaga tcacaaagct tgtcgttgaa 1577821 atgaaaagtt ctattgaaaa aataaaagaa caagtgcaaa atatagaata gtgactgtgc 1577881 gtattgttta cagacggtct tactaggcta aactagagac gtctatttta cagggggaac 1577941 gtagaagatg acgattaaac tgattaatat cggatttggc aatatcatct ccgccaatcg 1578001 gatgatttcg attgtcagcc cggagtctgc gccaatcaaa cggatgattc aggatgcaag 1578061 agaccgcgga atgctaattg acgctacata cggacgaaga acccgtgcag ttgtcgtcat 1578121 ggatagtgat cacattatct tatctgccgt ccagcctgag acagttgcac acagactttc 1578181 tgttaaagaa gaaattatgg atgaagggca ggggtaattg ccgcatgaaa gaaagagggt 1578241 tattaatcgt tctctcaggt ccctcaggag ttggtaaagg aacggttcga caagcgatct 1578301 tttcgcagga agacacaaaa tttgaatatt cgatttcagt aaccacaaga agtccaagag 1578361 agggcgaagt gaacggagtc gattattttt tcaaaacaag agacgaattc gagcaaatga 1578421 ttgcggacaa caagctgctt gaatgggcag agtatgtcgg caattattac ggcacgccag 1578481 tcgattatgt tgaacagacg cttcaagatg gaaaagacgt ctttttagaa attgaagttc 1578541 aaggggctct tcaagtgaga aatgctttcc cggaaggcct gtttattttc cttgcgcctc 1578601 caagcctttc tgaactgaaa aacagaatcg tgacacgagg aacagaaaca gacgctctga 1578661 ttgaaaatcg aatgaaagcc gcaaaagctg agatcgaaat gatggatgct tatgactatg 1578721 tcgttgaaaa cgataatgtc gaaacggctt gcgataaaat caaagcaatc gttcttgctg 1578781 aacatttgaa gcgtgaacgc gttgcaccaa gatataagaa aatgctggag gttgaataat 1578841 caatgttaga tccgtcaatt gattctttaa tgaataaatt agattcaaaa tatacgctgg 1578901 tgactgtttc tgcgagacgt gcccgtgaaa tgcaaatcaa aaaagaccaa atgattgaac 1578961 atacgatttc acacaaatat gtaggcaaag ctttagaaga aattgatgca ggcctgcttt 1579021 cgtttgaaaa ggaagaccgc gaatagtagc acaagtagca acctatatca tgtaggttgt 1579081 tatttttttc cgtgcggttt tgtaaagtgc agagggggag aattcattgc ttaacaatcg 1579141 aaatgtgtta ctttgcgtga gtggaggcat cgctgtttat aaagcctgtg cgttaacgag 1579201 caagctggtt caggcaggag caaatgtcaa agtgattatg actgaatccg cttgccgatt 1579261 cgtttcaccg ctgacatttc aggcattgag ccgccacgaa gtctatacag atacatttaa 1579321 agaacaaaat ccaagcgtca tttctcatat tgatgccgca gactgggccg acttgattat 1579381 cgtagcgccg gctacggcta atgtgattgg aaaactggca aacggcatcg ctgatgatat 1579441 gctgacgaca acattgttgg cagcaacggc tcccgtttgg atcgcgccgg caatgaacgt 1579501 tcatatgtat gaccacccgg cagtcaaacg aaacatttct gttctttatc aggacggtta 1579561 ttgttttatt gagccaagtg agggctattt agcatgcggt tacgtaggaa aaggcagatt 1579621 ggaagagccg gaaaacatcg taaagctggc cgaaaaacat tttgctgaag aaacatccgc 1579681 tcctttagaa ggcaagcatg tggtcattac agccggccca acgcgggaag cgattgatcc 1579741 tgtccggttt tttaccaata aatcgacggg caaaatgggc tacgcactgg cggaggctgc 1579801 tgttcagctc ggcgcacggg taatcttaat ttctgggcct gtttcacttg atcagcctaa 1579861 aggccttgct gagtttatcc ctgttcaatc ggctgcggat atgcgcgaag ctgtgctctc 1579921 tgtgtatgac gcaagcgata tagtcattaa aacagctgcg gtagccgatt ttacgccgaa 1579981 aacagtattt gaccataaaa tgaaaaaaca agacggcggc atgaccttag aactgaaaag 1580041 aacagtcgat attttgaaag aattgggcga gaaaaagaaa gagcagattt tggtcggatt 1580101 tgccgccgaa acacaagaca ttgaacacta tgcacgtaaa aagctcgccg ctaaaaacct 1580161 tgatttgatt gtggcaaatg atgtgaaagc aaatggggcc ggttttggtg ctgatacgaa 1580221 tatcgtgaca atctttttca aagacgggca taaacgcgaa ctcccgatta tgtctaagct 1580281 cgatgtttct tttgaaatcc ttcaggagat cgcagccctc tcaaaacaaa ccggagagcg 1580341 ctcatgaatt ttgcagaagt catcgttgat gtcagcacca aaaatataga caggcctttt 1580401 gattataaaa tcccagacca tctgaagggc atgatcaaaa cggggatgcg ggtcattgtt 1580461 ccgtttggcc cccgtaagat tcaagggttt gtgacagcag tcaaagaagc atctgaccta 1580521 tcgggaaaat ctgtcaagga agtagaggat ttattagatc ttacacctgt tctgacagag 1580581 gagcttatga ttctgtcatc atggctgtca gacaaaacgc tgtcttttaa aataacggcg 1580641 cttcaagcaa tgctgcctgc cgccttaaag gcgaaatatg aaaaagaatt aaaaattgca 1580701 cacggagccg atcttccgcc gcaagtggaa cggctgtttt ctgaaacaaa gacgctgctg 1580761 tattcagata tacccgatca tgagacgctg aaactgattc aaaggcatgt tcaaaaaggg 1580821 gacattgacg tgacgtataa agtcgcgcaa aaaaccaata aaaaaatggt caggcatatt 1580881 caggcaaatg cgagtaaaga agagcttgct aagcaggctg agggattgtc ccgccaagca 1580941 gcaaaacagc aggcgattct tcactttctc atctctgagc cggaaggtgt gaaaattcct 1581001 gcggcggaat tgtgcaaaaa aacggacacg agctctgcaa ccatcaaaac ccttatccaa 1581061 aaagggcttt tgaaggaaag ctatgaagag gtttacagag atccctatca ggacaaaatg 1581121 ttcaaaaaaa cagagcccct gccgctgaca gacgaacaga gggctgcctt cgagcccata 1581181 cgcgagacat tggacagcga tgagcataaa gtgttcctcc ttcacggcgt gacaggaagc 1581241 ggaaaaaccg aaatttatct gcaatcaatt gaaaaagtac tggcgaaagg aaaagaagcc 1581301 atcgtcctcg taccggaaat atcgctgacg ccgcaaatgg tcaaccgctt caagggccgc 1581361 ttcggctccc aggtggcagt catgcacagc ggtttatcca caggagaaaa atatgacgag 1581421 tggcgtaaaa tccaccggaa ggaagtacgg cttgtcgtcg gtgccagatc cgccattttt 1581481 gctccgtttg aaaatctcgg aatgataatc atcgatgaag agcacgagtc ttcctataaa 1581541 caggaagaaa tgccgcgcta tcatgcgaaa gaggtggcaa tcaagcgggc tgagcatcac 1581601 agctgcccgg ttgtattagg gagtgctacg ccgacattag aatcatatgc tagagcgcaa 1581661 aagggcgtat acgagcttct ttcactgaag caccgtgtta accatcgggt gatgcccgag 1581721 gtttcgcttg tcgatatgag agaggagctt agaaacggca atcgctcgat gttttcagtt 1581781 gaattgatgg aaaagcttga agaaacgatt gccaagggtg agcaggcggt gctgttttta 1581841 aataagaggg gctactcttc ctttgtgatg tgcagggatt gcggctatgt cccgcaatgc 1581901 ccgcactgcg acatttccat gacgtatcat cgttacggcc aaaggctgaa atgccattat 1581961 tgcggacatg aagagcctgt tccgcacact tgtcctgaat gcgcaagcga gcatatccgc 1582021 tttttcggaa cgggaacaca gcgagtggag gaagagctga caaaagtgct gccaagtgcg 1582081 agagtgattc ggatggatgt tgacacgaca tcacggaaag gcgcccatga aaaattactg 1582141 tcagctttcg gagaaggaaa agcggatatt cttctcggaa cgcaaatgat cgcgaaaggg 1582201 cttgattttc cgaatgtcac gcttgtcgga gtgttaagtg ctgatacaac acttcatatt 1582261 cctgatttca gatcggctga aaaaacattt cagctgttaa cgcaagtcag cggccgggca 1582321 ggcaggcatg aaaagcccgg ccatgtcatc attcaaacgt atacaccgtc tcattacagt 1582381 atccagctga cgaaaacaca cgattatgaa acgttctatc agcatgaaat ggcgcacagg 1582441 agagagcaat cctatccgcc atactactat ttggctcttg tgactgtttc tcatgaggaa 1582501 gtggcgaaag cagcggttac agctgaaaaa atcgctcatt ttttgaaagc aaactgcgga 1582561 gctgacacga aaattctcgg accaagcgcg tcgccgatag ccaggatcaa agatagatat 1582621 cgctatcaat gcgtgataaa atacaaacag gaaacccagt tatccgcttt attgaagaag 1582681 atactggaac attataaacg cgaaattgaa caaaaacatg taatgatttc aattgatatg 1582741 aatccttata tgatgatgta agatctcacg tcttggaggg taacaaattg gcagtaaaaa 1582801 aggtcgtcac acatcctgcg gaggttttgg aaacacctgc ggaaaccgtg actgtttttg 1582861 ataaaaagct aaaaaaactg cttgatgata tgtacgacac catgcttgaa atggatggtg 1582921 tcggactggc agcgccgcaa atcggcattt taaaaagagc ggccgtcgta gaaatcgggg 1582981 atgacagagg gagaattgat ctcgttaatc ctgaaatttt agaaaaaagc ggcgagcaaa 1583041 ccggaattga aggatgcttg agctttccta acgtctatgg tgatgtcaca cgtgccgatt 1583101 atgtcaaagt gcgtgcgttt aaccgtcagg gaaaaccgtt cattctggaa gcgcgaggct 1583161 ttttagcaag agccgtgcag catgaaatgg accacttaga cggtgtgctg tttacatcta 1583221 aaataagtaa atactataca gaagatgaac tagcggatat ggaaggatga tttgatgacg 1583281 agaatcgtat ttatgggaac gccggatttt tcagttcctg ttttaagaac cctgatagag 1583341 gacggatatg aagtagtggg ggtcgtcaca cagccggacc gtccgaaggg cagaaaaaaa 1583401 gtactgacac ctcctccggt aaaggaagag gcattgcgcc acggcatccc ggttcttcag 1583461 ccggaaaaag tcagattgac agaagaaatt gaaaaagtgc tggcattaaa gcctgacctg 1583521 attgtaacgg cggcattcgg acaaattttg cctaaagagc ttctcgacag tccaaaatac 1583581 ggctgcatta acgttcacgc atcccttttg ccggaactgc gcggcggtgc tccgatccat 1583641 tattccattc tgcagggaaa gaagaaaacc gggattacca ttatgtatat ggtagaaaaa 1583701 ttggatgcgg gcgatatgat ctcaaaagtg gaagtggaca ttgaagaaac cgacaatgtc 1583761 ggaacactgc acgataaatt aagcgttgct ggcgcgaagc tattgtctga aacggttcca 1583821 aacgttattg ccggcagcat atcacctgaa aagcaggatg aagagaaagc gacgtacgcg 1583881 cctaacatta aaagagagca agagctgctc gactggtcca gaacgggcga agagctttac 1583941 aaccagatcc gcggcttaaa tccatggcct gttgcttata cgactctaaa cggacaaaac 1584001 ttgaaaatat gggcgtcgaa aaaaatagcg gcaccaacaa cagctgagcc cggcacagtc 1584061 gttgcagttg aaaaggaagg aattatcgtt gccacaggta acgagacggc tctgttatta 1584121 accgaactcc agccggcagg caaaaaacga atgaaaggcg aagactttgt gcgaggcgct 1584181 catgttgaag ccggtgatgt gttaggagta aacaatgaaa aaaactagtg ttcgtgacat 1584241 cgcccttgag gcgctgatca aattagaaca aaaccaggca tacagcaacc tgctgctgaa 1584301 atcggtcatt aaatcaaatg aactgagtga tcagaacaga gggcttttga ctgaacttgt 1584361 ctatggtaca ttacaaaata agatcgcgct tgattatatg cttaaaccgt ttatcaataa 1584421 gcctcaaaag gtaaagccgt gggtgattca gcttcttcgc ctatccttat atcaaatgga 1584481 gtatttggag aagattccag acagggcagc cattcatgaa gcggttgaga ttgctaaaat 1584541 ccgcggacac aaaggcattg cttcatttgt caacggcgtg ctccgttcta ttcagcgcga 1584601 aggtgttcca tcctttgacg cgatcgaaga tcctgtccgc cggctggcga cagaaacaag 1584661 ccatccggaa tggcttgtga aagagtgggc ggatgcgtat ggatttgaag ctgcggaaaa 1584721 gatttgccgc atccatctca ttccgccgaa acagacgctg cgtgtcaatc aaatgaaagc 1584781 agacagagct gagctgcttg accaaatggc tgctgaggga atcgaagttg aaaaaggcga 1584841 cctcgctgaa gatgctgtga agctcttaaa gggaacaatt gccggaactc atttcttcca 1584901 aaacggcgaa gtttctatcc aggatgagag ctccatgctc gtcgcccgcg cccttgatcc 1584961 taagtcagat gaaacagtgc ttgacgcgtg tgcggcgcct ggcggaaagt cggctcatat 1585021 cgcagaatta atgaagaaca aggggagcgt tacgtcgctt gatcttcaca aacataaagt 1585081 gaagctgatc aaagaagcgg cagatcggct tggcctgaca atcattcatg cggaaacaat 1585141 ggatgctaga aaagcggggg aaacgtttga aaacgaacag tttgaccgaa tattggtcga 1585201 tgccccgtgc tcaggtttcg gtgttatcag aagaaagccg gacatgaaat acacgaaaaa 1585261 acctgacgac agcgcccgtc tagctgaaat ccagctgtcg atcttgaggg aaatcgcacc 1585321 attagtaaaa aaaggtggca ctcttgtcta cagtacgtgt acaatggacc ggacagaaaa 1585381 tgatgaagta atacatgcgt ttatacaaga acatcctgat tttgaacccg atttgtctct 1585441 tgaaaagcgg ctgcctgaaa aggtgagacc ctttgttcgg gatggaaggc ttcaaatcct 1585501 tcctcattat ttcggaacag atggtttctt tatttgcagc atgagaaaga agggataagc 1585561 aatggcagaa cttaataaaa caaaagtaag aaaagaattg cggacagagc gtccgtctat 1585621 ttattctttt gaattagatg aaatcaaaca atggctgaca gacaatggag agaaaccgtt 1585681 ccgtgcagcc cagatctttg aatggctata tgaaaaacgc gtatcttctt ttgaagatat 1585741 gacaaacctc tcaaaggatc tgcgtgagaa attaaacact cgctttgtgt taacaacgct 1585801 gaaaacggct gttaaacaaa cctctcaaga cggtacgatg aagtttttgt ttgagcttca 1585861 tgacggttat accatcgaaa ccgttttaat gagacacgag tatggcaatt ctgtatgtgt 1585921 aacgacacaa gtcggctgcc gtattggctg cacattctgc gcgtcaacgc ttggaggctt 1585981 aaaacgaaac cttgaagcag gggaaattgt cgctcaagta gtcaaagtgc aaaaagctct 1586041 tgatgaaacg gatgaacgcg tcagctctgt cgtgatcatg ggaatcggcg aaccttttga 1586101 taactttaac gaaatgctcg ctttcttgaa aatcattaac catgacaagg gcctgaatat 1586161 cggtgctcgc catattacgg tctctacgag tggaatcatc ccgaaaattt acgaatttgc 1586221 tgatcagcaa atgcagatta actttgcaat ttctctgcac gcgccgaaca cagaaatcag 1586281 aagccgtttg atgccgatta acagagcata taaactgcct gatctaatgg aagccgttaa 1586341 atattatatt aataaaacag gacgccgtat cagctttgaa tacgggctgt tcggaggcgt 1586401 aaacgaccag gtggaacacg ccgaagagct tgccgacttg ctggaaggag tcaaatgcca 1586461 cgtgaacttg attccggtaa actacgtgcc tgaacgggac tatgtgcgca caccgcgtga 1586521 tcagattttt gcttttgaaa aaacgctgaa atcccgcgga gtaaatgtca caatccgaag 1586581 agagcaagga catgacattg acgcagcctg cggtcagctt cgcgcgaagg agcgtcaaga 1586641 cgagacgagg tgatgagggt tgttaacagc cttaaaaaca gatacaggaa aaatccgcca 1586701 gcataatgaa gatgatgcgg ggatattcaa ggggaaagat gaatttatat tagcggttgt 1586761 cgctgatggc atgggcggcc atcttgctgg agatgttgcg agcaagatgg ctgtgaaagc 1586821 catgggggag aaatggaatg aagcagagac gattccaact gcgccctcgg aatgtgaaaa 1586881 atggctcatt gaacagattc tatcggtaaa cagcaaaata tacgatcacg ctcaagccca 1586941 cgaagaatgc caaggcatgg ggacgacgat tgtatgtgca ctttttacgg ggaaaacggt 1587001 ttctgttgcc catatcggag acagcagatg ctatttgctt caggacgatg atttcgttca 1587061 agtgacagaa gaccattcgc ttgtaaatga actggttcgc actggagaga tttccagaga 1587121 agacgctgaa catcatccgc gaaaaaatgt gttgacgaag gcgcttggaa cagaccagtt 1587181 agtcagtatt gacacccgtt cctttgatat agaacccgga gacaaactgc ttctatgttc 1587241 tgacggactg acaaataaag tggaaggcac tgagttaaaa gacatcctgc aaagcgattc 1587301 agctcctcag gaaaaagtaa acctgcttgt ggacaaagcc aatcagaatg gcggagaaga 1587361 caacattaca gcagttttgc ttgagcttgc tttacaagtt gaagagggtg aagatcagtg 1587421 ctaatcggca agcggatcag cgggcgttac caaattctcc gcgtcatagg cggcggggga 1587481 atggccaacg tgtatttagc tgaggatatc attctagacc gtgaagtcgc aattaaaatc 1587541 ctgcggtttg actatgcaaa tgacaatgaa tttatcagac gtttccgcag agaagcccaa 1587601 tccgcatcaa gcctcgatca cccgaatatt gtcagcattt atgatttggg cgaggaagat 1587661 gatatttatt atattgtcat ggaatacgtt gaaggcatga cgcttaaaga atacataaca 1587721 gcaaatgggc cgcttcaccc taaagaagcg ctgaacatca tggagcaaat tgtctcagcc 1587781 atcgctcatg cccatcaaaa ccagattgtt cacagagaca tcaagccgca taacattttg 1587841 attgatcata tgggaaatat caaagtaacg gattttggaa ttgcgacggc actaagttcg 1587901 accacaatca cccataccaa ttcagttctg ggctcggtcc attacttatc acctgaacag 1587961 gcccggggcg gcttagccac aaaaaaatcg gatatttatg cgcttggaat cgttctattt 1588021 gagcttttaa ccggccgtat tccgtttgat ggagagtcag cagtcagcat cgccttgaag 1588081 catcttcaag cggaaactcc ttcggcaaaa aggtggaatc catcggtccc ccaaagcgtt 1588141 gaaaacatca tactcaaggc aactgccaaa gatccttttc atcgctacga aacggctgaa 1588201 gacatggaag cagacataaa aacagctttt gatgccgaca gactcaatga aaagagattt 1588261 acgattcaag aagatgaaga aatgacaaaa gcgataccta tcattaaaga tgaagaactt 1588321 gctaaagctg ctggcgaaaa agaagctgaa gtgacaaccg cacaagaaaa caaaacaaag 1588381 aagaacggca aaagaaaaaa gtggccgtgg gttttgctca cgatatgcct cgtttttatc 1588441 acagctggaa ttcttgctgt cactgttttt ccgtcgcttt tcatgcctaa ggatgtcaaa 1588501 atacctgatg tctccggaat ggaatacgaa aaagccgcag ggctcttgga aaaagaaggt 1588561 ttacaggttg attccgaggt gttggaaatc tcagatgaaa aaattgaaga gggcctgatg 1588621 gtaaaaacgg atcctaaagc ggataccaca gtcaaagaag gcgccacggt caccctttat 1588681 aagagcaccg gaaaagcaaa aacggagatc ggtgatgtga caggccaaac ggtcgaccaa 1588741 gcaaaaaaag cgttgaagga ccaagggttt aatcatgtaa cagtaaatga agtgaatgac 1588801 gagaaaaatg cgggcactgt cattgaccaa aatccttcag cagggactga gctggtcccg 1588861 agtgaagatc aagtcaaact tacagtcagt atcggacccg aagacattac gcttagagac 1588921 ttgaaaacct acagtaaaga agcagcgtct ggatatctgg aagacaacgg attgaagctt 1588981 gtagaaaaag aagcatactc agatgatgtt ccagaaggac aggttgtcaa acaaaaacca 1589041 gcagcaggta cggcagtaaa gccgggaaac gaagttgaag tgacattctc tctcggacca 1589101 gagaaaaaac ctgcgaaaac agtgaaagaa aaggtcaaga tcccctacga accagaaaat 1589161 gaaggggacg agcttcaagt gcaaatcgcg gttgacgatg cggatcacag catctctgac 1589221 acttacgaag aatttaagat aaaagagccg actgaacgaa cgatcgaact aaagattgaa 1589281 ccaggccaaa aagggtacta tcaagtaatg gtaaacaata aagttgtcag ctacaaaacc 1589341 attgagtatc cgaaagatga ataacaagga gggaaaatat gcctgagggc aaaattatta 1589401 aggcgctaag cggcttttac tatgtactgg atgaatcaga ggattcagat aaagtaatac 1589461 aatgcagagg aagaggcatt ttcagaaaaa acaaaattac ccctcttgtc ggtgattacg 1589521 ttgtgtatca agctgaaaat gacaaagaag gatatctaat ggaaattaaa gaaagaacca 1589581 acgagcttat caggccgcca atttgcaacg ttgatcaagc ggtccttgtt ttctcagcgg 1589641 ttcagccttc tttcagcacg gcattgctcg accgcttcct ggttctcgtt gaggccaatg 1589701 atattcagcc gattatatgc attactaaaa tggatctgat tgaagatcaa gatacagaag 1589761 atacgataca agcctatgca gaagactatc ggaatattgg ttatgacgta taccttacct 1589821 cctctaagga ccaagatagt ttagcggaca tcatcccgca ttttcaggat aaaacaacgg 1589881 tatttgccgg tcagtccggt gttgggaaat cctcgcttct caacgcgatc agtccggagc 1589941 tcggattaag aacaaacgag atttccgagc atttgggccg cgggaaacac acaacccgcc 1590001 acgtggagct gattcacacg tccggaggtt tggttgcaga tacaccggga ttcagctcgc 1590061 ttgaatttac agacattgag gaagaagagc tgggctatac cttccctgat atcagagaaa 1590121 aaagctcttc atgcaaattt agaggctgtt tacatctgaa agagccgaaa tgtgcggtga 1590181 aacaagctgt tgaagacggg gaattaaagc agtatcgcta tgaccattat gttgaattta 1590241 tgacggagat taaagacaga aagccgaggt attagcataa tgataaaggt tgcaccatct 1590301 attctttccg ctgattttgc cgctttaggc aatgagatta aagatgtaga aaaaggcgga 1590361 gccgattgta ttcatattga tgttatggac ggccattttg tcccgaatat cacaatcggt 1590421 ccgctgattg tagaagcggt ccggccggta acggatctgc cgcttgatgt ccatttaatg 1590481 atagaagagc cggatcgtta tatcccggct tttgcgaaag caggcgcaga tatcctgtct 1590541 gtgcatgctg aggcatgtcc gcacctgcac cgtaccatcc agctcattaa agagcaagga 1590601 gtgaaggccg gagtagttct aaacccgcat acccctgtac aagtcatcga acatgttttc 1590661 gacgatcttg atcttgttct tttaatgacg gtgaacccgg gcttcggcgg gcagaaattt 1590721 attcattcag tccttcctaa aataaaagag gttaagcgaa tggcggatga aaaaggaaaa 1590781 aaagatctgt taattgaagt agacggcggc gtcaacaaag aaaccgctcc gctcgtcatt 1590841 gaagcgggcg caaatttact cgttgccggt tcagctgttt atggccagtc tgaccgcaaa 1590901 aaagcaattt ctgaaatcag aggaagtaaa taagcagctt tagaaaagag ctgggcatac 1590961 aatagcctaa gctctttttc ctgtatgcag agaaaggaat cagagatgaa aacaattaat 1591021 atcgttgcgg gaggcccgaa aaatctcatt cccgatctaa ccggctatac ggatgaacac 1591081 acgctttgga tcggtgttga caaaggcacc gtcactctct tagatgccgg gatcattcct 1591141 gttgaagcct tcggagattt tgacagcata acggagcaag aacgccggcg aatagaaaaa 1591201 gccgctcccg cccttcatgt gtatcaagca gaaaaagatc aaacagattt agacctcgcc 1591261 cttgattggg cgctggaaaa gcagccggat attattcaga ttttcggcat tacaggcggc 1591321 agagctgatc attttttagg aaacattcag cttctgtata aaggtgtaaa aacgaacata 1591381 aaaattaggc tgatagacaa acaaaatcat attcaaatgt tccctcctgg tgaatatgat 1591441 attgagaagg atgaaaataa gcgatatatc tccttcatac cgttttccga agacatacat 1591501 gagctgaccc tgaccggttt taaatatcct ctaaataatt gtcatattac gctcggttca 1591561 acactatgta ttagtaacga actcattcat tcacgaggta ctttttcgtt tgcaaaaggc 1591621 atattaataa tgataagaag cacggattaa gcatgtgctt tcattcaatt gctgaaaaca 1591681 atgaacaagg cggttacggg acgttatagg aggggacaaa aatgaaattt tacaccatta 1591741 aattgccgaa gtttttagga ggaattgtcc gggcgatgct gggctcattt agaaaagatt 1591801 aatgcccagg ggttcaaagc cctctttcac cacataaaaa cgcctgccac atatcggggc 1591861 aggcgttcat tttgttatac acgctcaact ttaccggatt tcaaagctcg agcagataca 1591921 tatacttttt taggttttcc gttcacaagg atacgaacct tttgaagatt cgcgccccaa 1591981 gtgcgcttag aagcgttcat tgcgtgagaa cggttattcc cagctgttgt ttttttacct 1592041 gtgataacgc atttacgtgc catttgtttc cctcctcact tgcacaaaac atctactttt 1592101 taacattcat ataatcttag atgctttcga tatggatact ttaaataatt taccacagct 1592161 aaaaaacgtt tgcaactatt gtttcatcat ctttcaagaa aattcacttg acatcttgcg 1592221 gaaacagcag cgctatagta tatgtagagg tacggccagc gattattgcc tggtcttttc 1592281 ataatggaaa ccatatagta gaatagctgt aactctatgc attcgaagga ggaactagtg 1592341 tgtccattga attaagaacg aagtacggac agattgatat atctaatgaa gtcatcgcga 1592401 tggttgcagg aggcgcggcg gttgactgtt acggcattgt cggcatggcc tctaaaaacc 1592461 agattaaaga cggactgact gaaatccttc ggaaagagaa tttcagcagg ggtgtccaag 1592521 ttcgccaaga aggagaacag atacatatcg acatgtatat cattgtcagc tacggcacga 1592581 aaatttctga agtggcacat aatgtccaaa caaaagtaaa gtacacagta aatcaaacca 1592641 tcggactggc agtggattct gtcaatattt atgtccaagg cgtacgagtg acgaacccgt 1592701 agttaggagg agtaggattg tctatcagaa cattagacgg cagaaccttt gccgagatga 1592761 ttcttgcggg agcgcagaat ctgtctcaaa acgccagtgc agttgatgca ctgaacgtgt 1592821 tcccggtgcc ggacggtgat acgggaacaa atatgaacct gtcgatgact tccggagcaa 1592881 gagaagttga acaaatggat acggatgata tcgggaaggt gggctccgcg ttatctaaag 1592941 ggctgctcat gggagcacgc ggaaattcag gagttatcct atcccaattg ttccgcggat 1593001 ttagcaaaaa cattgaaacg aaaaaagaaa ttaatgcact tgagtttgcc gctgcgctgc 1593061 aagcaggtgt agacatggcg tataaagctg tcatgaaacc tgtagagggc accattttaa 1593121 cagttgcaaa agacgctgca aaaaaagcaa tgatcttagc agaaaaagaa accgatatca 1593181 ctgcgctgat gactgcagtg acagaagaag cagaggcgtc tttaaaccgc acccctgaat 1593241 tgctacctgt cctaaaggaa gtaggagttg tcgatagcgg gggcaaaggc ctgctctgtg 1593301 tgtatgaagg tttccttgct tcattaaaag gtgaaactgt acctcagaaa gcagttcttc 1593361 cgtcacttga cgacatggtc agcgcagagc atcacaagag cgcgcaaagc atgatgaata 1593421 ccgaagatat tgaatttgga ttctgtaccg aagtgatggt taggcttgat cagacaaaaa 1593481 gagagttcga cgaaggcacg ttcaggcaag acctcagcca gttcggagat tctctgcttg 1593541 tgattgcgga tgaatcgctg gcgaaggttc atattcatgc tgaagagccg ggaaacgtgt 1593601 taaactacgc ccagcattac ggtgaattga tcaaaataaa aatagaaaat atgagagaac 1593661 agcatacctc tatcatcagt caagaaagca aacctgcaga caacgaaaca ccgccggcaa 1593721 aacagccgta tggcattgtg actgtagcga tgggagaagg aattgcagac ctatttaaaa 1593781 gcattggcgc ttctgttgtg attgaaggcg gccagaccat gaacccaagc actgaggata 1593841 ttgttgatgc cgtgaagtct gtaaatgcag atacggtatt tatcctgcct aacaactcca 1593901 acattatcat ggctgctaac caagcggcca gcgtagtgga tgaacaggtt tttgtcattc 1593961 ctgctaaaac ggttccgcaa gggatgtcag ctctgctggc ttttaacccg gatcaagaag 1594021 ctgaagcgaa cgaggccaat atgctaagcg ccattcagca agtaaaaagc ggacaggtga 1594081 cgttctcagt cagagatact catattgacg gtaaagacat taaaaaaggc gactttatgg 1594141 gcattctgaa tggaacgatt atcggcactt ctgaaaatca gctgtcagcc gcgaaaatgc 1594201 tgctgtcaga aatgatcgga gaagatgatg aaatcgtgac cattctatat ggtgaggatg 1594261 cgtctcagga agaagctgag cagcttgaag cgtttctcag tgaaaagtac gaggagattg 1594321 aggttgagat ccacaatggg aaacagcctc tgtattcgta tatagtttca gcagaataga 1594381 agggcaattt gcccttctat tcttatgtct gcttttaagt gcggcagcgc tgtaacgcgc 1594441 ccgcttgcca ttttatatct gatcaattag tctagaagca aagcgctaat aagctctggt 1594501 tcataaggag gaatagcatg aaatacagaa gcgtttttga tattatcggc ccggttatga 1594561 tcggtccgtc cagctctcat acagcgggag ctgctagaat cgggagagtg gccagaagtt 1594621 tatttggcag agagcctgag cgcatcattg tatcttttta cggctcgttt gcggaaacgt 1594681 ataagggcca cggcacagat gtcgcgatta tcggcggatt gcttgatttt gatacattcg 1594741 atgaacggat taaaaccgct atacaaattg cagaagctaa aggaattgat atagagtttc 1594801 gggtagaaga cgcagtcccg gtccacccga acacagcaaa aatcaccatt tctgatgaaa 1594861 agggtgagct ggaactgacg ggtatttcga ttggcggagg aaagattgaa atcacagaat 1594921 tgaatggttt tgagctccgg ctgtcaggaa atcatccggc catattagtt gttcataatg 1594981 acaagtttgg cacaattgcc ggtgttgcca atgttctggc gaaattttca atcaacgtag 1595041 gacatatgga agtagcccgg aaagatatcg gccagcttgc gctgatgaca atagaggtcg 1595101 atcaaaatat tgacgaccac attctcgacg agctgtcgaa gctgccgaat attattcaag 1595161 tgacaaagat tgctgactag cgaaaagggt caggaggagc cagttatgtt tcgtaatgta 1595221 aaagaattaa ttgagattac taaagaaaaa caaatattga tctctgatgt gatgatagct 1595281 caagagatgg aagtaacaga aaaaacaaaa gaggacattt ttcagcagat ggatcataac 1595341 ctgtctgtta tggaagcggc ggttcagaaa ggactcgagg gagttacgag ccaaacgggc 1595401 ttaacaggcg gagatgccgt taaattgcag gcctatattc gatcaggaaa aagcctgtct 1595461 ggcccgctga ttttagatgc tgtatcgaaa gccgttgcaa caaatgaagt aaatgcagcc 1595521 atgggaacca tctgtgcgac accgactgca ggttctgccg gtgtggtgcc cggtacgtta 1595581 tttgctgtaa aagaaaagct gaatccaaca agagaacaaa tgatccgctt tttgtttaca 1595641 gccggggctt tcggatttgt cgtggccaat aacgcaagca tttccggcgc cgccggagga 1595701 tgtcaggcag aggttggatc agcttcaggc atggcggctg cggctattgt tgaaatggca 1595761 ggaggaacac ccgaacaaag cgcggaagcc atggccatta cattaaaaaa tatgctaggc 1595821 ctcgtgtgcg accctgttgc agggcttgtt gaggtgcctt gcgtgaaacg gaatgcgatg 1595881 ggcgcgtcaa atgcgatgat tgctgctgat atggcattgg cgggcattac aagccgtatt 1595941 ccatgtgatg aggttatcga tgccatgtat aaaataggcc aaacgatgcc aactgcactt 1596001 agagaaacag gccagggcgg tttagcggca acaccgacag gaagagaatt agagaaaaaa 1596061 attttcggag gagcgctagg ttcacgtgaa acaacatcag caaactagta tagctaacat 1596121 taagggtatt gggccggaaa cagaaaaaac attgaatgaa ctcggtattt atgacatttc 1596181 tgatcttctg aattatttcc cttatcgcta tgatgactac gagctgaggg atttagaaga 1596241 agtaaagcat gatgaaagag tcacagtcga agggaaggtt cattcagagc cttctcttac 1596301 ctattacgga aaaaaacgaa acaggctgac attcaggctt ctggtcggcc actatttaat 1596361 cacagccgta tgttttaacc ggccttattt gaagaagaag ctttcgctcg gctctgtggt 1596421 gacggtttca ggtaaatggg acaagcaccg ccaaaccatc tctgttcagg agttgaaaaa 1596481 cgggccgcat caagaagaca aaagcattga accagtgtat tctgtgaaag aaaatgttac 1596541 cgtcaaaatg atgaggcgct ttattcagca ggcgctgacc caatatgcag actcacttcc 1596601 tgatcctctt ccggaaaagc taagaaaaag ctataaactg cctgactatt atcaagcgtt 1596661 aaaagcaatg caccagcctg aaacaaggga agcattaaag cttgccagac ggcggtttgt 1596721 ttatgaagaa tttttgttgt ttcagttgaa aatgcaggcg ttccgaaagg cggaaagaga 1596781 gcagacacaa gggatacggc agcgtttttc aaacgaagaa ctcatgagat ttatcaaaag 1596841 cctcccgttt cccctcacaa acgcccagtc acgcgttctt cgcgaaataa cagcagacat 1596901 gtcttctcca tacagaatga accgtcttct tcaaggggac gttggatcag gaaaaacggc 1596961 agtcgccgcc attgcactgt atgccgcgat cctatccgga taccaaggag cgctcatggt 1597021 gccgacagaa attctggccg agcagcatgc tgattcgctc gtttcgctat ttgaaaaatg 1597081 ggacgtcagc gttgctcttt tgacaagctc tgttaaagga aagcggcgaa aagaactgct 1597141 tgagcgtctt gcggcgggtg agattgatat tcttgtagga acccatgctt taatccaaga 1597201 cgaggtggag tttaaggcgt tgagtctcgt tattactgat gaacagcaca gatttggagt 1597261 tgagcagcgc aaaaagcttc ggaacaaagg gcaggatccc gatgttctct ttatgacagc 1597321 cactccaatc ccaagaacat tagcgatcac agtattcggt gaaatggatg tatctgtcat 1597381 tgatgagatg ccggctggac gaaagcgaat tgaaacctat tgggtaaaac atgacatgct 1597441 tgatcgtatt ttggcatttg tcgaaaaaga attaaagcaa ggcaggcagg cttatatcat 1597501 ctgtccgctg attgaagaat cagataagct tgatgtgcaa aacgccattg acgtgtacaa 1597561 tatgctttct gatatttttc ggggaaaatg gaatgtcggc cttatgcatg gaaagctgca 1597621 ttccgatgaa aaagatcagg tcatgagaga attcagcgca aatcactgtc aaattctcgt 1597681 atcaaccact gttgtggagg ttggcgtaaa tgttccgaat gcaacaatta tggtgattta 1597741 tgacgccgac cgtttcggac tatcacagct tcaccagctg cgcggccgtg ttggacgggg 1597801 tgagcatcaa tctttctgta ttctgatggc tgatccaaaa tcagaaacag ggaaagaacg 1597861 gatgaggatc atgtcggaga ccaatgacgg tttcgagctg tctgaaaagg atctggaact 1597921 gagaggtccc ggtgatttct tcgggaaaaa acaaagcgga atgccggaat ttaaagtggc 1597981 ggacatggtt catgattaca gagcgcttga aacggcaagg caggatgctg cgaatcttgt 1598041 ggcttctgac gcgttctgga aggagccgga atacgctgtg ttaagagatg aattgctgaa 1598101 gagcggagta atggacgggg aaaaattaag ctgagtatca gaagtttttg gtgttcagcc 1598161 agaaacaatc gttgcattcc aatctatgaa attatatact actattagta cctagtctta 1598221 attgtccgga tggtgtttag atatgagaag aaataagaga gaacgccagg aattacttca 1598281 gcagacgatt caagcaaccc cctttattac agatgaagaa ctagcgggta aattcggggt 1598341 gagcatccag acgatacgtt tggaccgctt agagctttcc atacctgaac tgagagaaag 1598401 aattaagaac gtggcagaga aaacacttga ggacgaagtg aagtccctgt cacttgatga 1598461 agttatcgga gaaattattg accttgagct ggatgatcag gcgatatcca ttttagaaat 1598521 aaaacaggag cacgtgttca gccggaatca gattgcgaga ggacaccatt tatttgcaca 1598581 ggcgaattct ttggccgttg cagtcattga tgacgagctg gcgctgactg caagtgcaga 1598641 catccgcttt acaagacagg taaagcaggg tgaacgtgtc gtagcaaaag cgaaagtgac 1598701 ggctgtcgaa aaagaaaaag gaagaacggt tgtcgaagtg aacagctacg ttggcgaaga 1598761 aattgttttt tctggacgct ttgacatgta tcgttcaaaa cattcataaa ggtggagcat 1598821 gcatgagaat agctgtagat gcaatgggag gagaccacgc tcccaaagct gttattgacg 1598881 gagttataaa aggtatagag gcatttgatg atctccatat cacacttgtc ggtgacaaaa 1598941 caacgataga atcacattta acaactacat cagatcgcat cacggtgctg cacgcagatg 1599001 aagtgattga gcctacggat gaaccggtcc gtgccgtgcg aagaaaaaag aactcatcta 1599061 tggttcttat ggcgcaggag gttgcggaaa acagagctga cgcctgcatt tcagcgggaa 1599121 ataccggtgc attaatgaca gccggtctct ttattgtcgg gagaattaaa ggaattgacc 1599181 gtccggcgct tgctccgaca cttccgactg tttcgggaga cggatttctt ctccttgatg 1599241 tcggcgccaa tgtcgatgcc aaaccggagc acctcgttca atatgccatc atgggttctg 1599301 tttattctca gcaagtgcgc ggtgtcactt caccgagagt cggactttta aatgtcggaa 1599361 cagaagataa aaaaggaaac gaactgacga agcagacgtt tcaaatttta aaagaaacag 1599421 caaacatcaa ttttatcgga aacgtggaag cgcgagacct tttagatgat gtggcggatg 1599481 ttgtagtaac agacggcttt accgggaatg ttacactcaa aacgctggaa ggctctgcgt 1599541 tgtcaatttt taaaatgatg agagacgtaa tgacgtctac tttgacatcc aagcttgcag 1599601 cagctgtgct gaaaccaaaa ttgaaagaaa tgaaaatgaa aatggagtat tcgaattatg 1599661 gcggagcaag tctttttggc ttaaaagcgc ctgtgatcaa ggcgcacggc tcttcagatt 1599721 caaatgctgt attccatgcg attcggcaag caagagagat ggtcagccaa aatgtggctg 1599781 cgctcattca ggaagaagtg aaagaagaaa aaacagatga gtagtctgga ggtttttaca 1599841 tcatgagtaa gattgcattt ttattcccgg gtcagggatc acaatttatc ggcatgggaa 1599901 aagagcttta tgagcaggtg cctgctgcaa agcgtctgtt tgatgaagcc gatgaaacgt 1599961 tggaaacaaa actcagctcg cttatttttg agggggatgc tgaagaatta acacttacat 1600021 acaatgcgca gcctgctttg cttacgacaa gcatcgctgt tcttgagaaa tttaaagaat 1600081 ctggcattac acctgatttc acagcaggac acagccttgg tgaatattct gcactggttg 1600141 cggctggcgc tctgtctttc aaagatgctg tttatactgt cagaaagcgc ggagagttta 1600201 tgaatgaagc ggtgccggct ggcgaaggag caatggctgc gattctcggc atggatgctg 1600261 aagcattaaa gcaagtaacc gataaagtca cagaggaagg caaccttgta cagcttgcga 1600321 atctcaactg tcctggccaa atcgtcattt ccggaacagc taaaggggtt gagcttgcat 1600381 ctgaactggc aaaagagaac ggcgcaaaac gcgcaattcc gcttgaagta agcggtccgt 1600441 tccattctga actgatgaaa ccggctgctg aaaagctgaa agaggtattg gacgcctgtg 1600501 acataaaaga cgctgacgtt ccggtcatct caaatgtttc tgctgacgtg atgactgaaa 1600561 aagcagatat caaagaaaaa cttattgagc agctttactc tccggttcgt tttgaggaaa 1600621 gcattaacaa gctgatcgca gagggtgtta cgacttttat tgaaatcggt cccggaaaag 1600681 tgctttcagg ccttgtgaaa aaagtgaata gacggttaaa aacaattgct gtatcagatc 1600741 cggaaacgat cgagctggca attcaaacgc ttaaggagga gaatgataat gcttaatgat 1600801 aaaacggcta ttgtcactgg cgcatcccgc ggaatcggcc gctcaatcgc ccttgatctg 1600861 gcaaaaagcg gagcaaatgt tgtcgtgaac tactccggca atgaagcgaa agcaaatgaa 1600921 gtggtagatg aaatcaaatc aatgggcaga aaagcaattg ctgtaaaagc ggatgtatca 1600981 aatcccgaag atgtacaaaa catgataaaa gaaacattgt ctgttttttc tacgattgac 1601041 attctggtta ataatgcggg aattacaaga gacaatctca tcatgagaat gaaagaagac 1601101 gaatgggatg acgtcattaa cattaacctg aagggtgttt tcaactgcac aaaagctgtt 1601161 acaagacaaa tgatgaaaca gcgttcaggc cgcattatta acgtatcgtc tatcgtcggc 1601221 gtcagcggaa accctggaca agccaactac gtggctgcaa aagccggcgt catcggttta 1601281 accaaatctt ctgctaaaga gctcgccagc cgaaatatta cggtaaacgc aatagcgcca 1601341 ggatttatct caactgatat gacagataaa cttgcaaaag acgttcaaga cgaaatgctg 1601401 aaacaaattc cgctcgcgcg ctttggtgaa cctagcgatg tcagcagtgt tgtcacgttc 1601461 ctagcttcag agggagctcg ttatatgaca ggccaaacgc ttcatattga cggcggaatg 1601521 gtgatgtaag ttttttctcg aaaatttcat cgtagtttct ctagtttttt aaaaacgaat 1601581 ccactataat acttgagggg aggtgaattg ctatggcaga cacattagag cgtgtaacga 1601641 aaatcatcgt agatcgcctt ggcgttgatg aagcagacgt caaacttgaa gcttctttca 1601701 aggaagactt aggtgctgat tccctagatg tagttgagct tgttatggaa cttgaagacg 1601761 agtttgatat ggagatttct gacgaagatg ctgaaaagat tgcaacagtc ggcgacgctg 1601821 tgaactacat acaaaaccag caataagctg atgctaaaag tcccgccgaa acgcggggct 1601881 ttagcccttt attcgtgcag ttattacagc atgccgcttt tacgcgcgct gtatccggtt 1601941 tagtcagaga agcgcggtga acctgatgtg cctatggagg ttactatgtc aaaacactca 1602001 cattataaag ataaaaaaaa gttctataaa aaagtagaac aatttaaaga gtttcaagaa 1602061 cggatttcgg ttcactttca aaatgaaaag cttttgtatc aagcatttac acattcatct 1602121 tatgtgaatg agcatcggaa aaagccgtat gaagataatg aaaggcttga atttttaggt 1602181 gacgctgttt tggaactgac gatctccaga ttcttatttg ccaaataccc ggctatgagt 1602241 gaaggagatt tgacgaaatt gagagccgca attgtttgcg aaccgtctct cgtttcattg 1602301 gctcacgagc tgtcattcgg cgatcttgtc ctgttgggta aaggcgagga aatgacaggc 1602361 ggaagaaagc gtcctgctct attggcggat gtttttgagg catttatcgg agccttgtac 1602421 cttgaccaag gattagagcc ggtcgaaagt ttcttaaaag tttatgtgtt ccctaaaatt 1602481 aacgatggtg ctttttctca tgtgatggat ttcaaaagcc agctgcagga atacgtgcag 1602541 cgggacggca aaggctctct ggagtataaa atctccaacg aaaaaggacc tgcgcacaac 1602601 cgtgaatttg aagccatcgt atctctaaaa ggtgaaccac tcggagtcgg aaacggccgt 1602661 tcaaagaaag aagccgaaca gcacgctgct caggaagctt tagctaaatt gcaaaaacac 1602721 catacgaaac aataaaatcc cccttatgac tcagggggat ttcagtatgt atgccgtctt 1602781 atttgaccaa tgtttatgat agaattgaaa tacttattac ataaggagga tcgctatgtt 1602841 cctcaaacgt ttagacgtta taggatttaa atcatttgca gaacggattt ccgtagactt 1602901 cgttaaaggc gtgacagcag ttgtcgggcc gaacggaagc ggaaaaagca acatcacgga 1602961 tgccattcgc tgggttctcg gcgaacaatc ggcacgctct cttcgcggcg gaaaaatgga 1603021 agacatcatt tttgctggga gtgattcaag aaagcgatta aatctagctg aagttacgct 1603081 tactcttgat aatgatgatc atttcttgcc aattgacttc cacgaggtga gtgtcacaag 1603141 acgtgtgtac agatcaggtg agagtgagtt tctgattaac aatcagccat gccgcttgaa 1603201 agatattatt gatttattta tggactctgg gcttggtaaa gaagcatttt ctattatcag 1603261 ccaagggaaa gtggaagaga tcctgagcag caaagcggag gatcgccgca gtatctttga 1603321 agaagcggcc ggggtgctta aatataaaac gagaaagaaa aaagcagaaa ataaactgtt 1603381 tgagacacag gacaatctaa atcgggtaga agatatatta catgagcttg aaggacaggt 1603441 tgaacctctt aaaattcaag cttcaatagc gaaagactac cttgagaaaa agaaagagct 1603501 ggagcatgtt gaaattgcgc tgactgccta tgatatcgaa gagctgcatg gtaaatggtc 1603561 gactcttaaa gagaaagtgc agatggcaaa agaagaagag cttgctgaat cgtctgctat 1603621 ttctgcgaaa gaagcaaaga ttgaggatac aagggacaaa atacaagcgc ttgatgagtc 1603681 agtagatgag ctccagcaag ttttactggt aactagtgaa gagctggaaa agcttgaagg 1603741 ccgtaaagaa gtcctgaaag aacgaaagaa aaacgctgtg caaaaccaag aacagcttga 1603801 agaagccatc gttcagttcc agcaaaaaga aacggttctg aaagaagagc tttcgaagca 1603861 ggaagctgtc ttcgaaacgc ttcaggctga ggtgaagcag ttaagggcgc aagtaaaaga 1603921 aaaacagcag gctctcagtc ttcacaatga aaatgtcgaa gagaaaatcg agcagctgaa 1603981 aagtgattat tttgagctgt taaacagcca ggcttcgata cgcaacgaac tccagcttct 1604041 tgatgaccag atgtcccaat ccgctgtcac attgcagaga cttgcggaca acaatgaaaa 1604101 gcacctgcag gaacggcatg atatttctgc gcgtaaagcc gcatgtgaaa cggaatttgc 1604161 ccgaattgag caggagattc acagtcaagt cggtgcatat cgtgatatgc agacaaaata 1604221 tgagcagaaa aagcgccaat acgaaaaaaa tgaatccgct ctgtatcagg cataccaata 1604281 cgttcagcaa gcgagatcaa aaaaggacat gcttgagacg atgcagggag atttctccgg 1604341 cttttatcaa ggtgttaaag aagtgctgaa agcgaaagag cgccttggcg gaattcgcgg 1604401 agcggttctt gagctgattt ctacagaaca gaagtatgaa acggccattg aaatagcgct 1604461 cggcgcttct gctcaacacg tcgtgaccga cgatgaacaa tctgcccgca aagcgattca 1604521 atatttaaag cagaattcct tcggccgggc gacgtttctg cctctttctg ttattagaga 1604581 ccgccagctt caaagccgtg acgcggaaac agccgcccgg cattcatcat ttctcggggt 1604641 tgccagtgaa cttgtcacat ttgatcctgc gtatcgaagc gtcatccaga atcttcttgg 1604701 aaccgttctg atcacagagg acttaaaggg tgcaaacgag cttgcgaagc ttctcgggca 1604761 ccggtaccgc atcgtaaccc ttgagggaga tgttgtgaac cccggtggtt caatgacggg 1604821 cggcgcggtt aaaaagaaaa ataactccct ccttggaaga agccgggagc tagaagatgt 1604881 gacgaaacgg ctcgctgaaa tggaagagaa aacggcactg cttgaacaag aggtcaaaac 1604941 ccttaagcac tccattcagg atatggagaa aaaactggct gacttaagag aaaccgggga 1605001 aggcttaagg ttaaagcagc aggatgtgaa aggccagctg tacgaacttc aagttgccga 1605061 gaaaaatatc aatacccatt tagagctcta tgatcaagaa aaatctgctc tgtcagaaag 1605121 cgatgaagag agaaaagtgc gcaaacgcaa gcttgaagaa gagctctctg ccgtatctga 1605181 aaagatgaaa cagcttgaag aggacataga cagactgaca aaacaaaaac aaacgcaatc 1605241 ctcaacgaaa gagtctctct ccaacgagct gactgagctg aagatcgcag cggccaaaaa 1605301 agagcaggct tgcaaggggg aagaggacaa ccttgccaga ttaaagaaag agctcactga 1605361 aacagagctt gcgttaaaag aagcaaaaga agacttaagc ttcttaacgt cagagatgtc 1605421 atctagcacc agcggcgaag aaaagctgga agaagcagca aaacataaat tgaatgacaa 1605481 aacgaaaacg atcgaactga ttgcattaag gcgcgatcag cgcatcaagc ttcagcatgg 1605541 gcttgatacg tatgagcgtg agctgaaaga aatgaaacgc ctgtataaac aaaaaacaac 1605601 gctcttaaaa gacgaagaag tcaaacttgg acgaatggaa gtcgagcttg ataatttact 1605661 ccaatactta cgggaggaat acagcttgtc ctttgagggg gcaaaagaga aatatcagct 1605721 tgaaactgat ccagaggaag ccagaaagcg cgtgaagctg attaaactcg caattgaaga 1605781 gctgggtacc gtgaacctcg gaagcataga tgagtttgag agggtcaacg aacggtacaa 1605841 gtttctgtcg gaacaaaaag aagatttaac agaagcgaaa aataccttgt tccaagtgat 1605901 tgaagaaatg gatgaagaaa tgacgaagcg ctttaacgac acattcgtcc aaatccgctc 1605961 acactttgat caagttttcc gctccttatt cggaggaggg cgagctgaac tgaggctcac 1606021 cgatcctaac gatctgcttc attcaggagt cgagattatc gctcagccgc cggggaaaaa 1606081 gctgcaaaac ttaaacctcc tgtcaggcgg agagcgtgcg cttactgcta tagcgctctt 1606141 attctcaatc ctaaaggttc gtccagtgcc gttttgcgtc cttgacgaag tagaggctgc 1606201 gctcgacgaa gcgaatgtgt tccgatttgc gcagtattta aaaaaataca gcagcgatac 1606261 tcagtttatt gtgattaccc acagaaaagg aacgatggag gaagcggatg tgctttatgg 1606321 cgtaaccatg caggaatccg gtgtttccaa ggtaatttca gttaagctgg aagaaacaaa 1606381 agaattcgtt cagtaacgag gaaagaggtt aaaagatgag cttttttaaa aaattaaaag 1606441 agaaaatcac aaaacagaca gattccgtat ctgaaaagtt taaggatggc cttgaaaaaa 1606501 caagaaactc ctttcaaaac aaagtgaatg atcttgtatc ccgttaccgt aaagtggatg 1606561 aggatttctt cgaagagctt gaagaggttc ttatcagcgc ggatgtcggt tttacaaccg 1606621 ttatggaatt aatagatgag ctgaaaaaag aagtcaaacg cagaaatatt caagatccaa 1606681 aggaagtcca gtcagtgatt tctgagaaac tggtcgagat ttataacagc ggagatgagc 1606741 aaatttcaga actgaacatc caggatgggc gtttaaacgt aatccttctg gtaggtgtaa 1606801 acggcgtcgg gaaaacaaca acgatcggaa agcttgctca taaaatgaaa caagaaggaa 1606861 aatctgttgt acttgccgcc ggagacactt ttagagcggg agccattgaa cagctggaag 1606921 tatggggaga gcgtacagga gtgcctgtca ttaagcagac ggcaggaagc gatccggcgg 1606981 ctgtcatcta cgatgctgtt catgctgcga aagcaagaaa tgccgatgta ttaatttgtg 1607041 atacggcagg gcgtctccaa aacaaagtaa atctcatgaa agagcttgaa aaagtaaaac 1607101 gtgttatcga aagagaagtt cctgaagctc cgcatgaggt gctgcttgcc cttgatgcca 1607161 cgaccggcca aaatgcaatg gctcaggcaa aagaattctc taaagcaaca aatgttaccg 1607221 gcattgcttt aacgaagctt gacggtacgg caaaaggcgg tatcgtcctt gcgattcgca 1607281 acgagcttca catcccggtt aaactagtcg gtttaggaga aaaagttgat gaccttcagg 1607341 aatttgatcc agaatcctat gtgtacggac tcttttcaga tttagtggaa aaagccgacg 1607401 attaagaaaa aggccccaac atcttggggc ctttttcttt tttatcttct tacttgatag 1607461 gcgaaatgat aaaggctgtt atcagtggat accagtcttg actcaccaga aaaaactctg 1607521 aatgggatga tgtcatagta atgaacggaa acagatgtgt aatacgtata gtaaccagca 1607581 gctggcccca aatacattgg aacctcaaat gttccgtttg catcagtcgt tcctgaagca 1607641 gtttgtgttg tgtttccgac cttcgtgtcc gcttcaaatc ttacgggcgc gtttggcact 1607701 ggctgtccgt tttggtcgag taatttgccg cttactgtaa tattgtactt gactcgccaa 1607761 tattgacctt gtccgtaatt gattttaccg tatacccctc catctgtgct gatatttgtg 1607821 attgaggcct tataaggtgc ctcagcagcg tctgcttgct gtgccgggaa acctattgta 1607881 aacagggctg ccagacataa cataaacaat aaaccgattt ttttcataaa aatcctcctt 1607941 aaaatagggt tcatatacaa tatcggaata aattggatga tatttagcgt attttggaaa 1608001 agttaatcgc cgctttgaca agataaaaac ttgacagtgt cattaaaacc gtgtaaacta 1608061 agttatcgta aagggatttg acttaacaaa ggggagagct caaatgtcac tcgaaaagac 1608121 aacgagaatg aattatctgt ttgattttta tcagtcgttg ttgacgtcaa aacagaagag 1608181 ctatatgtcg ctttattatt tggacgattt ctccctaggc gaaatagccg aagaatatga 1608241 ggtttcaaga caagctgttt atgataacat caaacgaaca gaagcaatgc ttgaacaata 1608301 tgaagaaaag ctgctccttt tgaaaaagtt tcaggagcgt aaagagatgt ttaataagct 1608361 gaaggagctt gcttccggtt caaaagaaga ggaagaaatt acagctctga ttgaagcgct 1608421 tgagaaatta gattaggagg cggcaaacta tggcatttga aggattagcc gaccgactgc 1608481 agcagacgat ttctaaaatc cgcggaaaag ggaaagtcag cgaacaagat gtaaaagaga 1608541 tgatgcgtga ggtccgtctt gcgctgcttg aggctgacgt taactttaaa gtagtcaagg 1608601 attttgtcaa aaaagtaagt gaacgcgctg taggccaaga cgtcatgaaa agtctgacgc 1608661 ccggccagca ggtcattaaa gttgttcaag aggaactgac tgagctgatg ggcggcgaag 1608721 agagcaaaat cgccgtcgca aaaaggccgc cgactgttat tatgatggtc ggtctccaag 1608781 gtgccggtaa aacgacaaca agcggtaagc ttgcgaatct gctgcgcaaa aagcataatc 1608841 gcaaaccgat gctggttgct gccgatattt accgcccagc cgcaattaag cagctggaaa 1608901 cactcggcaa acagcttgat atgcctgttt tctctcttgg cgatcaggtc agtcctgtag 1608961 aaatagctaa acaggctatt gagaaagcca aggaagaaca ttatgactac gtcattttgg 1609021 atacggcagg gcgcttgcat atcgaccatg aactgatgga tgaactgacc aacgtcaaag 1609081 aaatcgcgaa tccggaagaa attttcctgg ttgtcgattc aatgaccggt caggacgctg 1609141 tgaatgttgc caaaagcttt aatgaacagc tcggtttaac cggtgttgtg ttgactaagc 1609201 tggatggaga cacacgcggc ggggctgcgc tttctattcg cgctgtcaca aacacgccaa 1609261 ttaagtttgc aggtttgggc gaaaagcttg atgcgttaga gccgttccat cctgaacgca 1609321 tggcatcaag gattctcggc atgggcgacg tgctgacatt gattgaaaaa gcacaggcca 1609381 gcgttgatga agacaaagcc aaagagctgg aacaaaaaat gagaacgatg agcttcacat 1609441 tggacgattt tctggagcag ctcgggcaag tcagaaacat ggggccgctt gatgagcttc 1609501 tgcaaatgat gccgggtgca ggtaaaatga agggcctgaa aaacatccaa gttgatgaaa 1609561 aacagctgaa tcatgtggaa gcaatcatca aatcaatgac tgttcttgaa aaagaacagc 1609621 cggatattat caatgccagc cggcggaagc ggattgcaaa aggaagcggg acatccgtac 1609681 aggaagtcaa ccgtctgctt aagcagtttg atgaaatgaa aaaaatgatg aagcagatga 1609741 caaacatgtc aaaaggcaag aaaaaagggt ttaagctacc ttttatgtaa tcggttatac 1609801 atgataaaac cgttgttaag aaaaaacact ttacaaacac ttttatcatt gttaatatac 1609861 tatcttgttg aaatattttc ggaggtgcta gtaaaatggc agtaaaaatt cgtttaaaac 1609921 gtatgggagc aaaaaaatct cctttctatc gtattgttgt agcagattct cgttcaccac 1609981 gtgacggccg tttcatcgaa acagtcggaa cttacaaccc ggttgcaaaa ccagcggaag 1610041 taaaaattga cgaagagctt gctcttaaat ggcttcaaac tggagcgaaa ccatctgata 1610101 cagttcgcaa cttgttctct agccaaggaa tcatggaaaa attccacaac gctaaacaag 1610161 gcaagtaatg actgatcaac acttggaaga tttgattgtc cacattgtga cgccgcttgt 1610221 tgatcatcca gatgacattc gcgtcataag agaagaaacc gatcaaaaga ttgcgctgcg 1610281 cttatctgtc cataagtcag ataccggtaa agttatcgga aagcaaggcc ggactgcaaa 1610341 agcgattcga acagctgtat ttgcagctgg cgtacagtct tctaagaaag ttcaatttga 1610401 aatatttgac taaaagggag agggccggca cctccccttt ttttacacgc aaaaaaaggg 1610461 taaactgata gaagcttagg caaaatagaa aagcctggac gagtaaaagt tttaaaagcg 1610521 gggagcttgg tgcgatgcaa attattcacc gtgtagccgt tatgcaagtc ttaaccgagc 1610581 gcagtaaaga aaagctttta gcttcttttg ctgagaagaa acaaatgctt gaacgagaat 1610641 gcagccagct ctattttcag cttagaaaac atgagaaaga acagcaaaac cctaatatga 1610701 ttgaacaatt taaaaaggca atagaaaagc gaaaagatga tataaaaatc attgattttc 1610761 aaattgctca agtacataca ttgccgcttg gcagtgagtt gaaagaaaag gaagtcgatg 1610821 cgctgctgac gattgaagcc ggggatgact ggcatgagaa aacagcagcg aacaccatcg 1610881 tcataaaaga cggaaaagta attgaaattc gccagaggtg atcatatgac aaagcgatgg 1610941 tttaatgtag gcaaaatcgt aaatacccac ggaatcaaag gcgaagtgcg ggtgatttca 1611001 aaaacagatt ttgccgaaga acgatacaag ccgggaaaca cgctgtattt gtttatggac 1611061 ggccgtaacg aaccagtgga ggtaacggta aacacacata gactgcataa gcaatttcat 1611121 ctcctgcagt ttaaagaaag acaaaaccta aatgaagtag aagagctgaa aaacgcaatc 1611181 attaaagttc ctgaagaaga attaggagag ctgaatgagg gtgaatttta tttccacgaa 1611241 attattgggt gtgaagtatt tactgaagaa ggcgaactca tcggaaaggt caaagaaatt 1611301 ttgacgcctg gagccaatga cgtttgggtc atcggacgaa aaggaaaaaa agacgcactc 1611361 attccttaca ttgaatcagt ggttaaacat atcgatgtca gggaaaagaa aattgagatt 1611421 gaactcatgg aagggttaat agacgaatga aaatcgattt tttgacgctg tttcccgaaa 1611481 tgtttgaagg cgtgctcggc tcatcgattc ttcaaaaagc ccaggaaaaa gatgcggtgc 1611541 agtttcaagt cgtaaatttc cgagagtact ctgataacaa gcacaatact gttgatgatt 1611601 atccttatgg cggcggggca ggcatggttc tcaagcccca gcctgttttt gacgcggtcg 1611661 aggacctgac atcaaaggca gccgctgctc cgcgtattat cctcgtatgc ccgcaaggtg 1611721 agcgttttac ccaaaaaaaa gccgaacaat tagctaagga agagcatttg ctgttcattt 1611781 gcggccacta tgaaggctat gatgaacgca ttcgcgagca cttggtaacg gatgaaatat 1611841 caattggcga ctttgttctg acgggcggtg agctccctgc aatgatgatc gcagacagtg 1611901 tggtcagact gcttccgggt gtactgggta aagaggcttc ccatattgag gattccttca 1611961 gcaccggact tttagagcac ccgcattata caagaccggc agattacaaa ggtttaaaag 1612021 tgcctgaaac actcttgtca ggaaaccatg caaaaattga agaatggcgg aataaagaat 1612081 cgatcagaag gacctaccta agacgtccgg atctgttgaa agaccacccg cttacagagc 1612141 agcaaagaaa gtggatttct gaatgggaaa aagaatagat tttattgcat aggctatgaa 1612201 attgtgataa gatactactt gtggcttaag cgggcttatc cgctgcaagc ttgaaaacga 1612261 tgttccgctg tgccggtttt tgtggccaag agcatctgtt ggaaggagtt gaaaacgatg 1612321 caaaaactaa ttgaagatat cacaaaagaa cagcttcgta ctgatcttcc tgcgttccgt 1612381 cctggtgaca ctttacgtgt acacgttaaa gttgttgagg gtaaccgtga gcgtatccag 1612441 atctttgaag gtgttgtgat taagcgtcgt ggtggtggaa tcagcgaaac gttcacagtt 1612501 cgtaagattt cttacggtgt tggcgttgaa cgtactttcc cagtacacac accaaaaatc 1612561 gcgaaaatcg aagttgtacg ttacggtaaa gtacgccgtg ctaaacttta ctacctgcgt 1612621 gaacttcgcg gaaaagcggc tcgtattaaa gagatcagac gataatgata acgaacgaaa 1612681 agagcttgtt acctgtaaca agctcttttt ttatacagaa tttgaaaatg ccggacaggc 1612741 atcgtaaaat acataaagga caacaatgaa tcatgcatac tgaagataaa ggcggtgttc 1612801 gtgtcacatg acaattcaat ggttcccggg ccatatggca aaagcaagaa gggaagtaac 1612861 cgaaaaatta aaattaatcg atatcgtata tgaattggta gatgccagaa ttccaatgtc 1612921 atcaagaaac ccaatgattg aagatattct aaaaaacaag ccgcgaatta tgctgttaaa 1612981 caaggctgac aaagcagatg cggcagttac acagcagtgg aaagagcact ttgagaacca 1613041 ggggatccgc tctctgtcta ttaattctgt aaatggacaa gggttaaatc aaattgtgcc 1613101 tgcatcaaaa gagatcctcc aagaaaaatt tgaccggatg cgtgcgaaag gtgtgaagcc 1613161 gagagcgatt cgcgctttga ttatcggcat tccaaacgtc ggaaaatcaa cgctcatcaa 1613221 ccggcttgca aagaaaaaca tagcaaaaac gggagacaga cctggtatta cgacttctca 1613281 acagtgggtc aaagttggga aagaattaga gctattagat acaccgggaa ttttgtggcc 1613341 taaatttgag gatgagcttg tcggtttgag actggcagtc accggggcta ttaaagactc 1613401 gattatcaat ttgcaggacg tggccgtgtt tggtcttcgt tttctcgaag aacattaccc 1613461 agaacggctt aaagagcgtt atggccttga tgagatccca gaggacattg ccgagctgtt 1613521 tgatgcaata ggtgaaaagc ggggctgtct catgagcggt gggctcatca actacgataa 1613581 gacgactgaa gtcatcattc gcgatattcg cactgaaaag ttcggcaggc tgtcatttga 1613641 acagccgacg atgtaaaggc gcgcagaaat gcgggtcttt attttttctt ggctgaaccg 1613701 atacatacag taagggagaa gagaaagtga atacattaac cgtaaaggac attaaagacc 1613761 gtttgcagga agtgaaggat gcacaagacc catttattgc ccaatgcgaa aacgacccga 1613821 gaaaaagcgt tcaaacgctt gtagagcaat ggcttaaaaa gcaagcgaaa gaaaaagcgc 1613881 tgaaagaaca atgggtgaat atgacttcct atgaaaggct ggcaagaaac aaaggatttc 1613941 gcttgattgc aggtgttgac gaggtcggcc gggggccatt ggcaggacca gttgtcgcca 1614001 gcgcagtcat ccttccagag gaatgtgaaa tacttgggct gacagactcc aaaaagcttt 1614061 cagagaaaaa acgcgaggaa tattacgagc ttattatgaa ggaagcactg gcggtcggga 1614121 taggaattgt agaagctact gtgattgatg agatcaatat atatgaagct tcaaaaatgg 1614181 caatggtgaa agcgatacag gatttgtcgg atacacctga ttatttgctt gttgacgcaa 1614241 tgacacttcc gctcgacacg gctcaggcgt caattataaa aggcgatgcc aaaagcgtgt 1614301 ctattgcggc aggtgcgtgt atcgcaaaag tgacgaggga ccgaatgatg agcgcttatg 1614361 ccgaaacgta tcccatgtac ggctttgaaa aaaataaagg ctatgggaca aaagaacatt 1614421 tggaagctct cgctgcatac ggcccaactg aattgcaccg caaaactttc gctcctgttc 1614481 aatctttcag ataaatcacc atggacaagg aggcaccttt ttaaaatgaa catacgaaat 1614541 gatgtgcaaa aggcgctgca gcaccttttc gggcgtacag ccgtcccgca ggaaacatca 1614601 aaagtaaacg aagcgctaaa cggggagaag cgtctcctct taggaaaagt gcttcgttta 1614661 ctaggagatc agcatgccct gatccaagtc ggcaatcaaa ctgttcaggg aaaacttgaa 1614721 actcagcttc gtcctcaggc atactattgg ttttcctacg aaaaaaaaac ggcagagcaa 1614781 acaggccgtc ttcaggtcgt tcaaagcttt gatcaaaatc ctaaaaccat tcaggatgca 1614841 gctggcaaac ttttaaatgc tatttcagtg aagacgtcaa acgcagctct catgatgaca 1614901 ggagcgatgc tgaaaagcaa aacacccgta acagaaaatg atatcaaaac agctgtccgc 1614961 tggatggaca cgctgccttc gcaagacaca aaaaaagcag ttgaaacggt tctcttcgct 1615021 ttaaagcgtg atcttcccat tcactccgag attttgaatg gtgttcacgc tgtgaaatcg 1615081 cctgttccgt tgcatcagca cgtatcccag ctgctacagg caatcgacca aaaccctcag 1615141 cagagccaaa tgatgtcaaa gctaaaggaa gcagtcacgg tgcttttaaa tagtgaaatc 1615201 gatgtccatg cagaacggct gattgataag cttatttctt taaccgacaa tacgaaagca 1615261 ccttctccga cgaatacagc tggaagcagg gagcttagca caccagctgg ctcccccgga 1615321 aaagccagcc tgccgattgc aaatcacaca gcagaacagg gaagcataca agaagagcct 1615381 gttaaaacag cagcagacat tccaattaaa gaagcccgcc agctgctggt gaagctgacg 1615441 gaatctgctg aaaaaaacag tctccaaatt gtgaaagaag cagcaaattg gattaaagcg 1615501 gctgcttcat cgggtgatag taagtcactt gcagcttcag ctgttttaca ggcggcacaa 1615561 gtcacagatc aggaagccga agtcttttta aaggctgttc agcagacagc accccatttg 1615621 gcggataagg cagatgttct ttctttctta tccaaagtga aaacggcaat cggcgcaagg 1615681 gacgaggttg cgttcattaa agcgtttgaa caaggaagcg cagtcacatc tggcgaaatg 1615741 caatccatca agctggctct ttctgcctta agagcatcgc atgaggtagc cgaaccagtc 1615801 aaacaagaag ccgatcagct ttttcataaa ttaaatggcc agcttttcat gcagcaggac 1615861 catccatcat acagccaaat tgtaatgtca tttccgatgt tttcgaagtc aggggttcag 1615921 gacatgactg ttctgtttaa aggaaagaaa gaagcggatg gaaagcttga tccttcccat 1615981 tgccgccttt tgtttttgct gcagcttgat acactaaaag aaaccgtcgt tgattgcttg 1616041 gtacagcaaa aagtcatgac cattacaata gagactgatt tcgagctgca ggctgcgatc 1616101 gatccgatgg tgcccgcgct taaacagggg ctaaaggaaa tggggtacag cctttcaggg 1616161 gtaaacgcta aaaaaagggt tcacaccgaa gaaaaggctt caatcgatca atatataaca 1616221 agtatcagtg atcaggaagt ggatgtgaaa atatgaaaga gcagacaccg atcagaaaag 1616281 ctgttgctct ccattatgac gaacaaaaag acaaggcgcc gagagtgatt gccacaggga 1616341 agggccatgt agctgacaac attataaaag aagcgaaaaa agcaggggtc ccgattcaag 1616401 aagatcggac ccttgtcgaa ttaatgcgcc atttgacggt agatgatcaa attcctgaag 1616461 ctctttatga aacggtagcc gagatttttt cattcattta caaattggac gaaagcgtaa 1616521 aaaacaaaaa atagctaaaa tattccccat ccttctttga aatttatgtt tttaataaag 1616581 taaaagtttg aatgtttaga aggattaaaa gattttgcat cgaactgtag acaattcttc 1616641 cagtattatt atagaatgaa agcgcagtct attttagttt tgttacataa gttaggagga 1616701 tgggaaatga atatccatga gtaccaggga aaagaagtcc tcagaaaata tggggtatct 1616761 gttcctgaag gtaaagtggc ttttacagca gaagaagcag ttgagagtgc aaagagctta 1616821 tccagctcgg tttatgtcgt aaaggctcaa attcatgctg gcggtcgagg caaagctggt 1616881 ggggtaaaaa tagcaaaatc attagacgaa gtaaaagcgt atgccgaaga actattaggg 1616941 aagaccctag ttacacatca gacgggtccg gacggccaag taataaaacg cttacttatt 1617001 gaagaaggct gcgatattaa aaaagaatat tacatcggtc tagtgcttga ccgcgccact 1617061 tcaagaatcg ttttaatggc ttctgaagaa ggcggaacgg aaattgaaga ggttgcggag 1617121 aaaacaccag aaaaaatcaa aaaagctgtc attgatccag ctgttggcct tcaaggctat 1617181 caagccagag aaattgcatt cgctattaat attccaaaag agctcgtggg aaaagctgct 1617241 aaatttatgc ttggactata taaagcgttt gttgagaaag actgctcaat cgccgaaatc 1617301 aatccgcttg ttgtgactgg cgacggaaat gtgatggcgc ttgatgcaaa attgaatttt 1617361 gacagcaatg cgttgtaccg acaaaaggac attatggaat acagagattt ggatgaagaa 1617421 gatccgaaag aaattgaagc gtccaaatat gatctaagct acatttccct tgatggaaat 1617481 atcggctgta tggtaaacgg cgcgggactt gcaatgtcta cgatggatat tatcaagcat 1617541 tatggaggag aaccggccaa cttccttgat gtgggcggcg gtgcaaccgc ggaaaaagtc 1617601 acggaagcat ttaaaatcat tctttctgat caaaacgtta aagggatttt tgtcaacatt 1617661 ttcggcggca ttatgaaatg tgatgtcatc gcagaagggg ttgttgaagc gactagacaa 1617721 gttggtttga cattgccgct tgtcgtccgt cttgaaggca caaacgtgga tctagggaag 1617781 aaaatcctta gtgaatcagg attaaacatt acatctgcgg aatcaatggc tgacggcgcg 1617841 cagaaaatcg tatccttagt ttaagaaaga atgaaaggca ggggaccaaa taatgagtgt 1617901 tttcattaat aaagatacaa gagttattgt gcaagggatt acaggttcta ccgctttatt 1617961 tcatacgaag cagatgcttg aatacggcac aaatatcgtt ggcggtgtaa cacctggaaa 1618021 aggcggaaca gaagcggaag gtgttcctgt atttaataca gtggctgaag cagttcaaac 1618081 aaccggcgct aacgcgtctg ttatatatgt gcccgcaccg tttgcagctg atgcgattat 1618141 ggaagcggta gatgcggagc ttgatctcgt gatttgtatc acagaacata tcccggtttt 1618201 ggatatggtg aaggtcaaac gcttcatgga aggcaagaaa acgagactga tagggccgaa 1618261 ctgtcctggt gtcattacgc ctgaagaatg taaaatcggc attatgcccg gatacatcca 1618321 taaaaagggt catgtaggcg ttgtatcacg ttcaggaaca ttaacatacg aagcggtgca 1618381 ccagctctca gaagcgggtg tagggcaatc tacagctgtt ggaatcggcg gcgaccctgt 1618441 aaatggaaca aactttattg acgttttaaa agcgtttaac gaagatcctg acacacacgc 1618501 agtcatcatg attggcgaaa tcggcggtac ggccgaagag gaagcggcag agtgggtaaa 1618561 agccaacatg acaaaaccgg tagtcggttt tattggcggt aaaacagcac ctcctgggaa 1618621 gcgcatgggg catgcaggcg ccattatttc cggcgggaaa gggacagctg atgaaaaaat 1618681 caaaaccctt aatgcatgcg gaatcgaagt tgcagagaca ccttctgtca tgggtgaaac 1618741 cttaatcaag gtgctgaaag agaagaactt gttcgaaact tgtaaaacgc attaataaaa 1618801 aagggacagc cgtcaaggct gttcctgctt tttctaacaa aaggaggtca atctattgga 1618861 tcaggccgct gtctgcctaa cgatttgcag aatcaatcaa ttattatccc catcccttct 1618921 attaaaatgg tggaaagccg atccgtctat gtcgctgaca tcacccgtgt tacaaacggt 1618981 tactcgtgat caaataaaag cagctgcatt aaaaaacgaa atagaacaat tttatccaaa 1619041 gctcccgcgt gtacttgctg cttatcgtga gcaaggcatt aacaccatcc ctatttcttc 1619101 aaagcaatat cctttctggc ttaaaagcat ttatgatccc cctgccgtac tgtttgcaaa 1619161 aggtgatatg actcttcttt cgaaagggag aaaaattgga attgtaggca caagaaatcc 1619221 aacagcttat gggaaacaag ttgtcaatca tcttacaaaa gagatctgtc gtaaaggttg 1619281 ggtgattgtc agcggactgg cgtctgggat agacggaatg tcccatgctg caagtattaa 1619341 ggcgaagggg cggacaattg gcgtcattgc aggcggattt caacacattt atccccgaga 1619401 aaaccttcag ttagcagatc acatggctaa acaccatatc ctgctgtcag agcacccacc 1619461 tgaaactaaa ccccaaaaat ggcatttccc tatgagaaac cgtattatca gcggactaag 1619521 tgaaggcgtt attgtcgttc agggcaaaga aaaaagcggt tcgctgatta ctgcctatca 1619581 agcattggaa caagggagag aggtatttgc cgtacccggt tcattgtttg acccttacgc 1619641 cggaggtcct ataaaactga tccagcaggg ggctaaagcc atatggtcag cagaggatat 1619701 tttcgaggaa cttcctgaga gaaacgttca atatacggaa cccttttgaa ttatcgtttg 1619761 acaaacggta ttgtaatatt taataatagt gaggatttaa agttgcatat tgttttctat 1619821 ttaattaatg acgttcatga taaagaatga aatgttgaaa gccaaataaa gacagctgca 1619881 aaaataaaat tgaaatatct tgaaaagaga gagaacacct cttgaggggg atgaaaatgt 1619941 ctgattatct agtcatcgtg gaatcgcccg ctaaggcgaa aacgattgaa cgttacttag 1620001 gtaaaaaata taaagtaaaa gcatcaatgg gacatgtccg ggatcttcca aaaagtcaaa 1620061 tgggagttga catagaacag aattttgaac cgaaatatat taccattcga ggtaaaggcc 1620121 cggtattaaa agagctgaaa acggctgcga aaaaagccaa aaaagtgtat ctcgcagctg 1620181 accccgacag agaaggggaa gcgattgcat ggcatttggc acacagtctt gatttagatc 1620241 tcaactcaga ctgccgtgtg gtgtttaacg aaattacaaa agacgctatt aaggaatcgt 1620301 ttaagcatcc ccgcatgatc aatatggatt tagtggatgc acagcaagcg agacgtattt 1620361 tagacaggct tgtcggatat aaaatcagtc caatcttatg gaaaaaagtc aaaaaagggc 1620421 ttagcgcagg acgcgtgcaa tccgttgccc tccgtttgat tattgaccgt gaaaaagaga 1620481 ttaacgactt taagcctgag gaatattgga caattgacgg tacgttctta aaaggtcaag 1620541 aaacctttga agcgagcttt ttcgggaaaa acggcaaaaa acttccttta aatagtgaag 1620601 ctgatgtaaa agagattctt tctcagctca aagggaatca atatacagtt gaaaaagtaa 1620661 ccaaaaagga acgcaaacgt aatcctgctt tgccttttac cacttctacc ctgcagcagg 1620721 aagcggctcg caagctcaat ttcagagcga agaaaacgat gatgattgca cagcaattat 1620781 atgaaggaat tgatttagga agagaaggaa cggttggtct gatcacgtat atgagaacgg 1620841 attcaacccg tatttcaaat acggctgttg atgaagcagc tgcatttatt gatcagacat 1620901 atggaaaaga gttcctaggc ggaaaacgga agcctgcgaa aaagaatgaa aatgcccagg 1620961 atgcccacga agcaattcgg ccgacatcag ttcttagaaa accaagtgaa ttaaaagcag 1621021 tcctcggcag agaccaaatg agactgtata aattaatttg ggagcgtttt gttgccagcc 1621081 aaatggcacc ggctgttctc gatacaatga gtgtcgacct gacaaacaac ggtttgacat 1621141 ttcgtgcaaa tggaagtaaa gtcaagtttt ccgggtttat gaaggtgtat gttgaaggaa 1621201 aagacgatca aatggaagaa aaagaccgga tgctgcctga cttacaagaa ggcgacacgg 1621261 tattatcaaa agatatagaa cctgagcagc attttaccca gccgcctccg cgatatactg 1621321 aggcccggct tgttaaaacc cttgaagaac gcggtatcgg ccgtccatcc acatatgctc 1621381 cgacacttga tactattcag cggcgcggct acgtggcatt ggataataaa cgtttcgttc 1621441 cgactgaatt aggtcagatc gttcttgact tgatcatgga gtttttccct gagatcatta 1621501 acgttgagtt tacagctaaa atggagagag atcttgatca tgttgaagaa ggaaataccg 1621561 aatgggtcaa gattatcgat aatttctaca ccgattttga aaaacgcgtc aaaaaagccg 1621621 aatcggaaat gaaggaagtt gagattgaac cagagtatgc tggagaggat tgtgaattgt 1621681 gcagttctcc aatggtatat aaaatgggac ggtacggtaa attcttagct tgctccaact 1621741 tccctgactg ccggaacacg aaaccgattg tgaaacaaat cggtgtgaag tgcccgagct 1621801 gcggagaagg aaacattgtt gagcgaaaat cgaaaaagaa acgggtgttt tacggctgtg 1621861 accgttatcc ggactgtgaa ttcgtatcat gggacaaacc aattgaacga aaatgcccga 1621921 aatgcggaaa aatgctcgtc gagaaaaaac tcaaaaaagg tatacaagtc caatgcgtgg 1621981 aatgcgatta taaggaagaa ccacagaagt agcggtgagc agggtcttgc tcaccttctt 1622041 tgtgtgttaa aagaaggcct tgaataataa actaggagat gtgaaagatg aaccaacaaa 1622101 cagtgaatgt aatcggagcc ggactcgcag gaagtgaagc agcatggcag cttgccaaac 1622161 gtgggattca agtcaaattg tatgaaatgc ggccagttaa acaaacgcct gcgcatcata 1622221 cagataaatt tgctgagctt gtctgcagca actctcttcg ctctaataca cttgctaacg 1622281 ctgtcggtgt attaaaggaa gaaatgcgtg cgcttgattc agccattatc gctgcggctg 1622341 acgaatgttc ggtgcctgcc gggggcgctc ttgcagtaga ccgtcatgaa tttgccgcaa 1622401 gtgtgacaaa tcgggtgaaa aatcatccaa acgtaaccgt tattaatgaa gaagtgactg 1622461 aaattcctga aggccctact atcatcgcaa cgggtccgtt aacatctgaa tcgctgtctg 1622521 cccagctgaa ggagctgact ggagaggact atttatattt ttatgacgca gcggcgccaa 1622581 ttgtagaaaa agacagcctt gatatggata aagtgtacct gaaatcccgt tatgataaag 1622641 gtgaagcagc atatttgaac tgcccgatga cagaagaaga gtttgaccgt tttcatgaag 1622701 cattaacatc agcagaaaca gtgccgttaa aagaatttga aaaagagatt ttctttgaag 1622761 gctgcatgcc gattgaagtc atggcaaaac ggggtaagaa aacaatgctt ttcggtccga 1622821 tgaaaccagt tggtctagag catcctgtta caggaaaacg cccttatgcc gtcgttcagc 1622881 tcagacagga tgatgctgcg ggaacacttt ataatattgt aggattccag acacatttaa 1622941 aatggggaga ccaaaaggaa gttctcaagt tgattccagg acttgaaaat gtagaaatcg 1623001 tcagatatgg cgtgatgcat agaaacacat ttattaactc tccaagcctg ttaaagccga 1623061 cttatcaatt taaaaaccgc agtgatctgt tctttgcagg ccaaatgacg ggagtagaag 1623121 gatatgtgga atcagctgcc tcaggacttg tagcaggcat taatgcggcg aagcttgtat 1623181 tgggagaaga gcttgtgatc ttccctcagg aaacagcaat tggcagtatg gcacattata 1623241 ttacaacaac aaaccagaag aacttccagc cgatgaatgc aaactttggg cttttgaaag 1623301 aattgccagt taaaattaaa aataaaaaag aacgaaatga acaatacgcg aaccgtgcga 1623361 ttgaaacaat tcaaacaatt tcgaaaacaa tataggtatt gattgcaacc tgagcgcgat 1623421 ttgtgatacc atttaaaagc ccttcctggg gaggtattag gcatggagaa tgttaagaat 1623481 ttcgtaaagt tattcgttga atatttacaa attgaaaaaa attattcaca atatactatt 1623541 gtgaattatg tggattcaat tgaagaattc gagactttcc tgcgcgttca aggtataaat 1623601 ggatttgaag aagctgcata tcaagatact aggatttttt tgacagaagc ctatgaaaaa 1623661 ggtttatcga gaagaacaat aagcaaaaag atatctgcat taagaagctt ttataagttt 1623721 ctgatgcggg aaaagcttat tgaagaaaat ccgtttcagc ttgttcatct gccaaaacag 1623781 gagaaacgga taccgaagtt tctatatcaa aaagagcttg aggagctgtt tgaagtttca 1623841 gatataagcc agccggccgg aatgagggat caagcgctgt tagagctgct ctatgccact 1623901 ggaatgaggg tcagtgaatg ctgttccata actattaacg acgttgattt atttatggac 1623961 actgtgcttg ttcacggtaa aggcaagaag cagcgctata tcccctttgg gtcttatgcc 1624021 cgcgaagcgt tgaaggtata catgaatagc ggaagacagt gcttgctgat gaaggcaaaa 1624081 gaacctcatg atctattatt cgtaaatcaa agaggcggac cgcttacagc ccgtggcatc 1624141 agacatattt taagcgggct tgttcaaaaa gcgtcaagca ctttacatat ccatccgcat 1624201 atgcttcgac atacgttcgc cacgcatctg ttaaatgaag gagcggattt gagaagcgtt 1624261 caagaactgc tcgggcattc caatctgtct tctacacaga tatacacgca cgtttcgaag 1624321 gaaatgttga gaaacacata tatgtctcac catccaagag catttaagaa aaattaaagg 1624381 aggcccttta tgtcatcttt tcatgcgacc acaatatttg ccgtacagca taaaggacga 1624441 agcgctatgt ccggagacgg ccaagtaaca tttggtcagg ctgttgtcat gaaacacacg 1624501 gcacggaaag tgagaaaact gtttaacggc aaagttcttg ctggttttgc gggatctgtt 1624561 gcagacgctt tcactttatt cgaaaagttt gaagctaagc ttgaagaata taacggcaac 1624621 ttaaaacggg cggctgttga gcttgcaaag gaatggcgca gtgataaagt gctaagaaag 1624681 ctcgaagcca tgctgattgt tatgaatcag gatactttgc ttctcgtatc gggaacaggc 1624741 gaggtgatcg aaccagatga cggcattctc gcgattggat caggaggcaa ttacgctttg 1624801 gcagcgggaa gagcactgaa aaagcatgcc ggggaaagca tgtctgcaag tgagattgcc 1624861 agagccgcgt tagaaacagc aggcgaaatt tgtgtttaca cgaacgatca aatcatactg 1624921 gaagagcttg aatagaaagg acttgaggcg catggaaaaa aaaccgttaa ctcctagaca 1624981 gattgtagat cggttagacc aatatattgt cggtcagcaa aatgcgaaaa aagctgtcgc 1625041 cgtggcatta agaaaccgct atagaagaag tcttctggat gaaaagctga aggacgaggt 1625101 cgttccgaaa aacattttaa tgatgggtcc taccggcgtc gggaaaactg aaattgccag 1625161 acgaatcgct aagctttcag gtgcgccatt tatcaaaatt gaagctacta aatttaccga 1625221 agtcggctat gtaggcagag atgttgaatc aatggtcaga gatcttgtgg agacttctgt 1625281 tcggcttata aaagaagaga aaatgaatga agtaaaggaa caggcagaag aaaatgcaaa 1625341 caaacgcatt gttcgtctgt tagttcctgg gaagaaaaaa caatctggtg ttaaaaatcc 1625401 gtttgaaatg ttttttggag gcagccagcc gaatggtgaa gatgaggcgg agagccagga 1625461 agaagcaaac atcgaagaaa aaagaaaacg aatggcgcat cagctggctt taggagagct 1625521 cgaagactac tatgtaacag tagaagtcga agaacagcag ccttctatgt ttgacatgct 1625581 gcagggctcg ggtatggagc agatgggtat gaacatgcag gatgcgctga gcggattaat 1625641 gccaaagaaa aagaagcggc gcaaaatgac agtcagagaa gccagaaaag tcctgacgaa 1625701 tgaagaagca agcaaactca tcgatatgga tgaagtcggc caggaagctg ttcagagagc 1625761 agaagagagc gggattatct ttatcgatga gattgataaa atcgcaaaga acggcggtgc 1625821 atcttcttct gccgatgttt caagagaagg tgttcagcgg gatatccttc cgattgttga 1625881 aggttctacc gttgtcacaa aatatggttc tgtaaaaaca gaccatgtat tatttattgc 1625941 agcaggagcg tttcatatgg ccaaaccgtc tgatttgatt cctgagctgc aggggcgttt 1626001 cccgattcgt gtagaactga acaaactcac ggtagacgac ttcgtgagaa ttttggttga 1626061 gccggataat gcgctgctga aacaatatca ggcattattg cagacagaag gtatatctct 1626121 tgaattttct gacgaagcta ttcataagat tgctgaagtt gcttatcatg tgaaccagga 1626181 cacagataat atcggtgcga gacgccttca tacaatactt gaacgcctat tagaagattt 1626241 gtcgtttgaa gctccagatg taacgatgga gaaaataacg attacaccac agtatgtcga 1626301 agaaaagctc ggaacgatag ccaaaaacaa agatttaagt caatttatat tgtgaaaaat 1626361 ttaatatgag gaatgtttag gaggattatt tatcatggct ttattacaaa aaacaagaat 1626421 tattaactcc atgctgcaag ctgcggcagg gaaaccggta aacttcaagg aaatggcgga 1626481 gacgctgcgg gatgtaattg attccaatat tttcgttgta agccgcagag ggaaactcct 1626541 tgggtattca attaaccagc aaattgaaaa tgatcgtatg aaaaaaatgc ttgaggatcg 1626601 tcaattccct gaagaatata cgaaaaatct gtttaatgtc cctgaaacat cttctaactt 1626661 ggatattaat agtgaatata ctgctttccc tgttgagaac agagacctgt ttcaagctgg 1626721 tttaacaaca attgtgccga tcatcggagg cggggaaaga ttaggaacac ttattctttc 1626781 gcgtttacaa gatcaattca atgacgatga cttaattcta gctgaatacg gcgcaacagt 1626841 tgtcggaatg gaaatcctaa gagaaaaagc agaagaaatt gaagaggaag caagaagcaa 1626901 agctgtcgta caaatggcta tcagctcgct ttcttacagt gagcttgaag caattgagca 1626961 catttttgag gagcttgacg gaaatgaagg tcttcttgtt gcaagtaaaa ttgctgaccg 1627021 tgtcggcatt acccgttctg ttattgtgaa cgcactcaga aagctggaga gcgccggtgt 1627081 tatcgagtct agatcattag gaatgaaagg tacttatatc aaggtactaa acaacaaatt 1627141 cctaattgaa ttagaaaatc taaaatctca ttaatcacaa aaagaaccct ttttgagggt 1627201 tcttttttta tttcaaataa aggaaatcaa taagctttat ttcctgggtt gaaagtcttt 1627261 ctatgtaata attttaataa attttgcatt tttcttcaaa aagtttcaaa aatgccgaaa 1627321 agaaaggaga aaaaacagaa attctgctat tttcaggctt atatcaaggc gagaaatgta 1627381 gttctaacaa tctaggactt tatacctagt tgcaaaatag ataattgtga ggacattttt 1627441 ttacacgaac ttcatagact ttatgcctgt tatttcttac aataagcata tagttttaca 1627501 attctcgaca aggatattga gggtgaaaaa aactgaaatg gaggtaagtg gatttgagct 1627561 tattttctgg aacgatacaa aatcttgaaa atgccttgag cagagcggat attaagcaaa 1627621 aagtcataac taataatatc gccaatatag atacaccgaa ctataaggca aaaaaagtct 1627681 ctttccaaaa tttattagat caagaatcct cgcgtcttga agcgataaaa acagactatc 1627741 gtcatgttga tttttctgat actgattcga attattcaat tgttgcgagc ggagatacat 1627801 cgtatcagca aaacggaaac aatgttgatg ttgacaaaga gatgacagaa ttggcgcaaa 1627861 atcaaatcaa ctatcaagct ttggttgaaa gaatgaacgg taaatttaat tcgctgaaga 1627921 ccgtattaac aggaggaaaa tgatgacagc ttttcatagc ttaaatgttt cagcatcggc 1627981 tttaacagct cagcgagtca gaatggacgt tgtatcatct aacttagcaa atatggatac 1628041 gacaagagct aagcaggtga atggagagtg ggtgccttac agaagaaaaa tggtttccct 1628101 tcagtcaaaa ggtgaatcgt tctcttccat tctcaattct caaatgagcg gaagcgggaa 1628161 tgctggaaac ggtgtgaagg tttcaaaaat tacggaggat gattcggatt ttaatcttgt 1628221 ctatgatccg acagaccctg atgcaaacgc tgaaggatat gtacaaaagc ctaatgttga 1628281 tccattaaag gaaatggttg atcttgtcag cagcactaga tcatacgagg cgaatgtcac 1628341 ggcgatgaat gccacaaagg gaatgctgat gaaggcgtta gaaatcggaa agtaggtgaa 1628401 tgaatgtgat taatgcaatt tctccttttc aggttcaaaa tactcaaaac actcaaaatg 1628461 caacaaatca agtaaacaat agccaaaaaa cagattcttc aaatcaaaca agcttttcgg 1628521 agcttttaaa aaactctatt agttcgttaa atgagtccca agtagcttct gacaacatga 1628581 ctaatgcctt ggctgcagga aaagatgtaa atcttgatga ggtcatgatc gctgctcaaa 1628641 aagctagcat ctctctaact gcagcaacag agttccgcaa taaagctgtg gaagcttatc 1628701 aggagattat gagaatgcaa atgtaggggg tctgacgatt tagagaaaga gtggaatgac 1628761 cgggggttaa catgaatcgt actctaatgc aaatgaaaaa caaaacgagt gagttttgga 1628821 aaaatagatc taaattacaa aagattttaa tggttagtgc tttagcggca attattatta 1628881 ttggaattat tattagtgtt tttgcttcaa attctaaaat ggcgccgctg tacaaagatt 1628941 tgtctgccga agaagcagga caaatcaaag aagaattgga tgcaaaaaaa gtgccaaacg 1629001 aactttcgaa tggcggtaca gtgattagtg ttccggagga tcaggttgat tctttgaaag 1629061 tgcagatggc tgcagaagga cttcctaaaa cgggatcaat tgattattcg ttttttggac 1629121 agaatgccgg ctttggtttg acagacaatg agtttgatat ggtgaaagtg aaagctacac 1629181 agacagaact gtcaaacttg atcaatgaaa tggacggtat taaaaattca aaagtaatga 1629241 ttaatctccc gaaagacgct gtgtttgtcg gtgaagagca atctgcagca tctgcatcaa 1629301 tcgttttgca gattcaaccg ggttatacac ttgatcaaag ccaaatcaac ggattatatc 1629361 atctggtatc taaaagcgtg ccaaacctaa aagaagataa catcgtcatc atggaccaaa 1629421 attctacata ctacgacaaa tcagacagcg atgcagggtc ctacgcggat agttattctt 1629481 ctcagcaagg aattaagtct caagttgaaa aagacattca aaaacatgta cagtcactgc 1629541 tgggtacgat gatgggccaa gataaagtcg ttgtctccgt tacagcagac attgatttca 1629601 caaaagaaaa tcggacagaa gacattgtcg aacctgtgga taaagaaaac atggaaggca 1629661 ttgcagtcag cgctgaaaag gtatctgaaa catatcaggg cgacggtgca gccaacggcg 1629721 gaactgccgg aaccggcgag gaagatgtta caaattataa ggctgacggt gaaaataccg 1629781 aaagcgggaa ctacgaaaaa aacagcaaca aaatcaatta cgaggttaac cgaattcata 1629841 aagaaatcgc tgaaagtcct tataaggtca gagatttagg gattcaagta atggtagagc 1629901 cgcctgatgc caaaaacact gcgtcgctat caactgaaag acaggatgat atacaaaaaa 1629961 tcctttcaac tgtagtcaga acatctttgg ataaagatga aacgcaaaat cagaatttat 1630021 ctgatgctga tatcaataat aagattgttg tttccgttca gccattcgac ggaaaagtca 1630081 atttggatac aaatacggaa gaatcctcag gtatcccgct gtgggcatat attgtaggcg 1630141 gtgttttaat cgcagcgatc attgttctga tcattatgct tatcagaaag aaacgggcgc 1630201 aagaggatga atttgaggaa tatgagtatg aggttcctca agaaccaatc aatttgcctg 1630261 atatcaacga agaggaaaat gaaacagcgg aatcagtcag acgaaaacag cttgaaaaga 1630321 tggcgaaaga caagccggaa gattttgcaa aactgctgag aagctggctg gccgaggatt 1630381 aggaggaatt agaaatggcg agacgtgatc aagataagct tacaggaaaa caaaaagcag 1630441 ccattctcat gatttccttg gggttagatg tgtcagcttc tgtctataag cacttaaccg 1630501 atgaagaaat tgaaaggctt actctggaaa tatcaggtgt tcgaagcgtc gatcatcaaa 1630561 aaaaggatga aatcatagaa gaatttcata atatagccat tgcgcaagat tatatttctc 1630621 aaggcggttt aagctatgca agacaagttc tggaaaaggc gcttggagag gataaggcgg 1630681 agaacattct aaacaggctg acttcttctt tgcaggttaa accatttgat tttgccagaa 1630741 aagcggagcc agaacaaatt ttgaatttta tccagcaaga gcatccgcag acgatggcgt 1630801 taatcttgtc ttatttagat ccagtgcagg ccgggcaaat tttatccgag ctgaaccctg 1630861 aagtgcaggc tgaggttgcg agaagaatcg cggtcatgga tagaacgtct ccagaaataa 1630921 ttaacgaggt agaacggatt ctggaacaaa aattatcttc tgcatttact caggattata 1630981 cacaaacagg cggaattgaa gctgttgtgg aagtgttaaa cggggtagac agagggacag 1631041 agaagacgat cttggattca ttggaaattc aggatcccga tcttgctgaa gagattaaaa 1631101 agcggatgtt tgtcttcgaa gatattgtca cacttgataa ccgtgcaatt cagagagtca 1631161 ttcgcgatgt tgagaacgac gatttgctcc tttcattaaa ggttgcaagc gaggaagtca 1631221 aagaaattgt gttcaacaat atgtcacagc gtatggttga aaccttcaaa gaagaaatgg 1631281 agtttatggg ccctgtacgt ttgaaagatg tagaagaagc tcaatcaaga attgtaagca 1631341 tcgtcagaaa gcttgaagaa gccggtgaaa ttgtaatagc aagaggcgga ggggatgata 1631401 ttattgtcta atatcattaa acaagaatca tctatttctc cacaaaagga aaaaagaaaa 1631461 ctttctatac aagaggtgcg tattgatcat tctcaccttt tgcaggctga agagaacccg 1631521 gaggcgctta tggcccgagt gaaagaggaa gctgaccgga tttctgagca ggcaaacagt 1631581 catatagaaa atattcgccg tcaaattgaa caggagaaaa acgattgggc ggctgaaaaa 1631641 cagaagctta ttgaagaagc aaaagccgag ggctttgaac aaggagtagc gctgggcaaa 1631701 gctgaggcaa tgaaacagta tgcagaactg atcggccaag caaacagtat aactgaaatg 1631761 tccagaaaag ctgttgagga caagcttgaa gacgctaatg aagaaatcgt tgagcttgcc 1631821 gttgccctag caaaaaaagt ttggcagcaa aagtctgatg ataaagaggc tttcctcctg 1631881 cttgtacaac aggttataaa cgaagtgaag gaatatgacg atatatcaat ttatgttgat 1631941 ccatattact atgagacaat ctttcagcaa aaagatgaaa tccagcagct tctttataaa 1632001 gaatgtcggc ttggcatata tgctgatgaa aaagctcaaa aaggaacctg ttatattgaa 1632061 actccttttg gcagggtaga tgcgagtgtt gacacacaat tgatgcaatt gaaagataaa 1632121 cttctgacag cgctggaagc aggtgcagct gaatgaagac acagagtctg atagattgta 1632181 tagaaatgac agactcgtat aaacggtacg gaaaagtcaa gcgggtaatc ggcttgatga 1632241 ttgaatcaaa agggccagca agctcaattg gtgacctgtg cctgatttat gcaaaaggac 1632301 agtctgggaa agtcattaaa gctgaggtag tcggcttcca ggaagaaaat attttgctta 1632361 tgccttattt agaggctgcg agcattgcac ctggcagcat tgtagaagct actggggaat 1632421 cacttcgggt taaagttggg accggactga tcggacaagt catcgatgct tttggagaac 1632481 cgcttgacgg aaagcttctg ccgaaagggc tttcgcctgt atcaacggag caatcaccgc 1632541 ctaacccgat gaaacggccg cctatccgtg aaaagatggg tgttggagtc agatcaattg 1632601 acagcttgct gacagtcggt aaaggccagc ggattggaat ttttgcagga agcggtgtcg 1632661 gaaaaagcac cttaatgggg atgatcgcca agcagacaga ggctgactta aacgtcattg 1632721 cacttgtcgg agaacgcgga cgagaggttc gggagtttat tgaaaaagat ctggggaaag 1632781 aggggctgaa acgatcgatt gtagtcgttg ccacctcaga ccagccagca ttaatgagat 1632841 tgaaagcggc atatacagcg actgcaattg ccgagtattt ccgagataaa ggccaaaatg 1632901 tcatgtttat gatggattct gttacaaggg tggcaatggc gcagcgagag attggactgg 1632961 ctgcaggaga gcctccgacg acaaaaggct atacaccttc agtgttcgct attttacctc 1633021 gtttactaga acgaacaggt gcaaacgagc atggaaccat tacggcattt tatacagtgt 1633081 tggtagatgg ggatgacatg aatgagccga ttgccgatac cgtacgcgga attttagacg 1633141 ggcatattgt gttggacagg gcgcttgcca ataaaggcca gtttcctgca gttaacgtac 1633201 taaaaagcat cagcagggtg atgtcaaaca tttcaacaaa acagcatctg gatgcggcaa 1633261 ataaattccg tgaactttta tcgacatatc aaaattcgga agatctcatt aatatcggag 1633321 cttacaaaag aggatcatcc agagaaattg atgaagcgat acaattttat ccgcagctta 1633381 ttcaattttt aaagcaggga acagacgaac cggctttatt ggaagaaagc attgctgcat 1633441 taactagttt gacaggaaat gaggaataaa cgtggcttat caatttagat tccaaaagct 1633501 gctggaacta aaagaaaatg aaaaagacca atccttatcc gaatatcagc aatcagtttc 1633561 tgaatttgaa aacgttgctg aaaaattata tgagaatatg agcaaaaagg aattgctgga 1633621 acaaaataag gaaaagaaat taaaaagcgg catgagtgta caagaaatga ggcactacca 1633681 acaatttgtc tcaaatcttg ataatacgat ctatcactat caaaagcttg tcattatgaa 1633741 aagaaatcaa atgaatcaaa aacaagaaat tttgacagag aaaaacattg aagtgaaaaa 1633801 gtttgaaaaa atgcgtgaaa aacagtttaa aatgtttgct cttgaagata aagctgcaga 1633861 aatgaaagaa atggacgata tttcgattaa gcagtttatg attcaaggcc attaggagcg 1633921 aatgtaatgt ccggcaaaaa gaaagaatca ggtaagttcc gttcggtttt gcttatcatt 1633981 atcctcccgc tgatgtttct attaatcgca ggggggattg ttctttgggc tgctggtatc 1634041 aatgtcttaa agccgataca ggatgctgcg gcaaaaacgc cggttcttaa agaattggtc 1634101 cctgaaaccg aaaataaaaa aggcgcagca tcaagtaagg atagcagtaa tacggcagct 1634161 ctggaaaaga ccattaagga tcaaaaaagt gaaatcagta tattgaataa agatttagaa 1634221 acaagtaaat cagaaatcga caggctcaat caaaagatcc gttcacttga aaagacggct 1634281 gaggatcaaa aaaagtcatc agaagatcat actgaaggat cagcagactc gaaagcttct 1634341 tctgaaaatg acaaagtgat cagtgtgtac aaaagcatgg acagcggaaa ggctgctaaa 1634401 attattgccc aattaaagga gcaagaagca ctgaaaatat tgaatggcct aagcaaaaag 1634461 cagcttgctg acatattggc gaaaatgact cctgagcaag cagcaaccta tacagaaaaa 1634521 attgctgcca gccaagaata gggggaatga aaggtgaagc tgcttgaatt agccggacct 1634581 ttgctgcaaa ccacaacggg ttctgccgct aaaaacatga aaagtagcca gggagttttt 1634641 caaaactggc ttatgtctga ggctggattg aaggaacttt cagaacaagg aaagggaact 1634701 cctaattctg aagatcagct tttagcagat gcgcttaaaa agatcggtga atggctaaat 1634761 gcaagtcctg aagatcaaga caaacaaaat gcggatcttt tgcaaacatt aagcaaactg 1634821 acagggaagc aattggatgc gaatgctctg caaatgttgc aaaatctttt gcaagcagtt 1634881 gaatcaaaaa tgtcaggcgg gacggatcaa ttgctcacag aaacggagaa aatcttttca 1634941 gaagctaaaa cggctctgag tgccaatgat tctgcttctg acattaatgg agcactgaag 1635001 tctgataaag agcaatcaaa tcaggaaaat gaagtatccg agcctgcaaa agagcttatc 1635061 tatatccaga tgttcattag ccagctcgta gaagggaata agctgactga tctcgggaat 1635121 ggcaatgaag ctcatgccat ttaccaaaat ggagatcaat tcctttctgc attagaaaag 1635181 aagggtgtat ctcaacaact aattcaggat cttaaacagc aaatattcac taaagctgag 1635241 tcaagttcaa aactttactc gatgacagcg tcagagctga aaagttttca aagcttaatg 1635301 gatcaaatgt ctatgcttcc tcaaaaaggg accaaagaat ggagtttagc tgaaagccag 1635361 ctgaaagcct tcttgttatc gaaatcatcc gaatcatcac aagactttgg gaagagtgtt 1635421 ctcacaccgc tctcgcagag ttcatccagc aaaaatgcat cggatgtttc tggaagtatt 1635481 cagcctgtag atagtaaatc aggactccaa atgctgtttt cggggtatcg gggcatagga 1635541 ggagttcaaa cacttgatct gcagcagatg tcatctgata taccaaatgc cgaaacaaaa 1635601 acggtggctg atcaagtgat taatgcgtgg aagcagatga aatatacgcc tttcggcaga 1635661 tcgacgggaa gtttcactat tcggctgaac cctgaacatt taggatttgt cacaatcaag 1635721 ctgacaaatg aaaatggaat gtttcagagt aaaatcatag catctagcca atcagcaaaa 1635781 gaattgcttg aacagcatct tcctcagctg aagcaatcat tgccgaatat ggccgtccaa 1635841 attgaccgtt ttactcttcc ggtccaaagc ggggatcagc cgatatacgg ccagcttgct 1635901 gatgaacaga aacagcagca agaggggcag agacagcaaa gacagaaaaa gcaatcaaat 1635961 gattttggcg atctgctcga tgaagtgtcg atggttgaaa tggaggaaga agaatgactt 1636021 ctataagttc agaatataaa ctgcctgaaa aaacgaacac tgtgtcgacg aacaacagca 1636081 gcttggggaa agacgagttt ttaaaaatat taatgactca agttcaaaac caagatccgc 1636141 ttaacccgat tgacgataaa gaatttatca gccagatggc gactttttca agcttggagc 1636201 aaatgatgaa tctgaatacg acaatgactc aattcgttga aaaccaagat ccgtttacaa 1636261 cgtatgttga ttggatggga aaagaagtat cttggactga tggtaaaagt gcaacagata 1636321 aaacaggcac agtaagctct gttaaacatt ttaaaggaaa ttattatctc gttcttgatg 1636381 atgggaccga gatcagtcct gcgaatgtca tgtctgtggg acaatcatct aaataaaaac 1636441 atctggggga atatattatg ttacgttcac tttattctgg aatcagcggt atgaaaaact 1636501 ttcaaacaaa gcttgacgta atcggtaaca acattgccaa cgtaaataca gtaggattca 1636561 aaaagagccg tgtgaccttt aaagatatgg taagccaaac gattgccggc ggttctgctg 1636621 ctggtgcaac aatcggcgga acaaactcta agcaaatcgg tttaggttca tcatctggca 1636681 caattgatac aattcattca acaagcgcga cacaaagcac aggaagaaca cttgatttag 1636741 caattgacgg cgacggttac ttccgaattg atacaggtga cgggacagct tatacaagag 1636801 cagggaactt ctatttagat aatactggaa cactggttac aggtgatggc taccatgtac 1636861 taaatatgaa tggcggaaca attaaaattc ctactgatgc tcaaagcttt agcattggtt 1636921 ctgatggaaa ggtgtcaatt gttgatgctg aggggaaaac acaagacggg ggacaaatcg 1636981 ggattgttac ttttgccaac agtgatggat tggataaaat cggaagcaac ctataccgtg 1637041 aatctttaaa ctctggaacg gccagtgcag cgaaccagcc tggtgacggc ggaactggtg 1637101 ctcttaaatc aggatttctc gaaatgtcta acgtcgattt aactgacgaa tttactgaaa 1637161 tgatcgtagc ccagcgcgga ttccaatcaa actcaaaaat tattacaaca tctgatgaaa 1637221 tccttcaaga actggttaac cttaaacgtt aaggagggag gggaggcgag taatcgcttc 1637281 tccgctgttt tatgattaaa gtaacccgtt tgaacgggca gccctttaca ctgaatgcgc 1637341 tatttattga acagattgaa tgttttccgg atactacaat tactctgtca aatggtaaga 1637401 agtttgtagt aaaagaagat gaagaagctg ttctggaaaa gatcgcagct ttctaccgaa 1637461 aaatacaaat atttgcaatg gatcaaggaa tagaggaacc ggaatgaaga aaaagttaat 1637521 gatcatatta ctaattattc ttatcgtaat tggtgctctc ggggcggcgg cttattttgt 1637581 tttaggcgga aagtccgaaa aaagtgaagc gaaaaaaagt attgatgaaa tcgttgcgtc 1637641 ttctgttgat gtagaagaga tcacaacaaa tttaaagtct gataacatta tccgtcttgc 1637701 tattaaactt gaaactgatt ctgataaatc aaaagaagaa cttgagaaac gtgatttcca 1637761 agtgaaagac gctgttatat cactgctggc tgatacgaat gctgatcaga ttgagggaga 1637821 caagggaaaa gaaaccttta agaaggaact aaaagataaa ataaatagct acctccaaga 1637881 aggaaaagta gaaaaagtgt atattacctc ctttaatctg caataaagca taatttgaca 1637941 gaatacggag gtgaggaaaa tgtcaggaga agttctctcc caaaatgaaa tagatgcact 1638001 gctctctgca atatcaactg gtgaaatgga cgctgaagag ctgaaaaaag aagaaaaaga 1638061 gaagaaagtc aaggtttatg atttcaaacg tgcgctgcgg ttttctaagg atcagatccg 1638121 cagtttaacg agaattcatg acaattttgc aagacttctt accactcatt tttctgctca 1638181 gctcagaacc tatattcaca tatctgtcag ttctgttgat caggttccgt atgaggaatt 1638241 tatcagatcg attccaaaca tgacgattct gaatctattt gatgttcatc cgatggaagg 1638301 aagaattatg atggaggtca accccacgat agcttatacg atgatggatc gagtcatggg 1638361 cgggattgga atcagtcata acaaggttga cagtttgaca gaaattgaaa caaaaatcat 1638421 ttctaattta tttgaaaatg cactgggtaa ttataaagaa gcttggcagt caattgctga 1638481 tattgaaccg gaaatgactg agtttgaagt gaatccgcaa tttgttcaga tggtatctcc 1638541 taatgaaaca gtcgtggtga tctcgctcaa tactcaaatt ggtgaaatca gcggtgtcat 1638601 taatctctgt atcccgcata ttgtactcga gccgctcata ccgaagcttt cagtccacta 1638661 ttggatgcaa tcagaccgaa atgagccaaa gcctgaggaa acaaagtcgc ttgaaaaacg 1638721 tatcatgaca gcacaaatac ctgtcgtggc cgagctcggc acatctgaac tgacgataga 1638781 agagttttta agtttagaag tcggagactg cataactttg gacaaatcag tcacggatcc 1638841 tcttactgta ttggtcggag ataagccgaa atttttagga caagccggcc gggtgaatcg 1638901 aaaacaggca gtgcaaattt tagatcacga cataagaggt gaacaagatg gagaataata 1638961 gattatctca agatgagatt gacgcgcttc ttaacggtac tggcagcacg cttgatgagc 1639021 cagagattcc ggaagtagat gacttatcgg aaatggagcg tgatgcgatc ggtgaaatcg 1639081 gtaatatttc attcggcagt tctgcgacag cactgtcaac gcttttaaat caaaaggtcg 1639141 atattacgac tccaagcgta acggtcattc caagaagtaa aatcagcgat gcgtttcctg 1639201 aaccgtatgt agcgattgaa gtgaattata cggagggctt cagcggaagc aacctgttag 1639261 tcgtggaaca aagtgacgcg gcgatcattg cggacttaat gatcggggga gacggaaaag 1639321 gtgcggaccc ttcactgggt gaaatccatt taagtgcggt tcaagaagca atgaaccaaa 1639381 tgatgggatc ggctgccaca tcaatgtcta ctgtattcag taaaaaaatt gatatttcac 1639441 ctcctcgggt tgaattgctg gatgttactg aagaaaaggg tacagaccgt attcctgatg 1639501 atgaaatgct ggtgaaagtt tctttcaact taaaggtggg agaattaata gactccagca 1639561 ttatgcaact ttacccattg acatttgcga aagatttaat ttcaagcctt atgaactcag 1639621 aaagtgcaga ggaagaagaa acggtgcagc ctgaagttac atacgaacag ccgaaagagc 1639681 ctgtgacgcc agagccgcgt attgaaccga agcaacagca gcagccgcca aaaaggcagg 1639741 gaacagcaaa aaaagcagcg ccagttcagg tttcaccggt ggaattttcc gcgtttgatc 1639801 caaacgaagc tgtacaagcc cctattcata atctggatat gcttttggat atcccgcttt 1639861 cgattactgt tgagcttggc agaacgaaga gaagcgtaaa agagatttta gagctttctg 1639921 ccggaagtat tatcgagctt gataaattag ccggtgagcc tgtagatatt ttagttaatc 1639981 agcgtatcgt tgccaaaggc gaggtcgttg tcattgaaga aaacttcgga gtgagagtca 1640041 ctgacatttt aagccaggca gagcgcatta ataatttaaa ataacgaaac acaaggagag 1640101 agatagatta tggcacatag aattttaatt gtagatgacg cagcatttat gcgaatgatg 1640161 attaaagata ttttggttaa aaatggtttt gaagttgtgg cggaagctga aaatggagca 1640221 caagcggtag agaaatataa agagcattca cctgaccttg ttactatgga tatcacgatg 1640281 ccagaaatgg atggtattac agcattaaaa gaaattaaac aaattgatgc gcaggcaaga 1640341 atcatcatgt gttctgctat gggacagcaa tcaatggtta ttgatgccat tcaggccggc 1640401 gctaaggatt tcattgtgaa acctttccag gctgaccgtg tgcttgaagc aatcaacaaa 1640461 acattaaatt aaagggtgta cgactgttga aaaagagtca atattttatt gtttttattt 1640521 gttttttcgt tttattcagt gtacatccga ttgctgctgc cgcggcagac tctgataatt 1640581 caactgtaaa cgaatggttt caaaagaaag atgaaaaaac tgcagatcaa tcagagcaaa 1640641 agaaagaaaa aacaacaaaa actgctgatg agacggaggg agcggctgct ccttctgtct 1640701 cagcttttga ttttgtaaag atgattttcg ctttactgtt tgttatcgtg ctgatttacg 1640761 ggctggttaa gctcatgaac aaaagaaatc ggctcctaaa gccttttcaa tatgttgaaa 1640821 atattggcgg cacatcggtc ggtcagaaca gatccataca attgatcaag gtcgggaaaa 1640881 gtgtgctcgt cgtcggtgta ggagagacga tccagctgct gaaagaaatt gaggatgaaa 1640941 aagagattga agtcattctc agtcagcatg aagaggcaat gtcaagcaaa atagagtggc 1641001 aaaagtttgt gaagccgctt aagagttctg aacatcagcc gcagcaaaaa ctgccttcat 1641061 tttcaaaagc attaaaagag caacttgaag agttaaaaca aaaccgttct gaaggaaaga 1641121 agaaaggccc acgtcatcat gaatgagttt ataaatattt tcagttcaag cgatccggaa 1641181 aacgtaagtt cgactgttaa attactatta ttgttaactg tattttcagt ggcgcctgga 1641241 atattgattc ttatgacttg ttttactcgc atcgtcattg ttctgtcatt tgtcagaact 1641301 tcacttgcga cgcaatctat gcccccaaac caggttctaa tcgggcttgc gctgttttta 1641361 acatttttta ttatggctcc tactttttca gaaattaata aagaagcgct gaccccatta 1641421 atggacaaca aaatcagctt ggatgaagcg tatacgaaag ctgaggaacc gattaaagaa 1641481 tttatgagta aacacacaag gcagaaggat ctggcgctgt ttatgaatta cgcgaaaatg 1641541 gataaacctg aatcattaaa ggatattccg ttaacaacaa tggttccggc ttttgccata 1641601 tcggagctta aaacagcatt tcaaataggt tttatgattt ttatcccttt tttaattata 1641661 gatatggtag tggcgagcgt cttgatgtca atgggaatga tgatgctgcc tccagttatg 1641721 atttctctgc cctttaaaat attacttttt gttttggtag acggctggta tttaattgtg 1641781 aaatctttgc ttcagagctt ttagggtagg tgctaaacgt gagttcagaa tttgtaattt 1641841 ctatggcgga aaaagccgta tacgtaacgc tgatgatcag cgggccatta ttggctattg 1641901 ctttactggt cggtttaatt gtcagcatat ttcaggcgac aactcaaatc caggaacaga 1641961 ctttggcgtt tattccgaaa atcgtggcgg ttctcctggc tctcattttt tttggtccgt 1642021 ggatgctgtc gacgattctt tcatttacaa cagagctgtt ttctaattta aatcgttttg 1642081 cagggtaatg tagagatgaa ttcaattatt gacttatttc ctgctttttt attggttttt 1642141 attagaatct ctgctttttt tgtaacgatt ccgctatttg gacatcgaaa tgtgccagct 1642201 gttcatcgca taggttttgc tttttttctt gcggtcattt gtttcagcac cattgataaa 1642261 ccgccctctt tggagataga tgagcactat atgcttttgg cgtttaaaga agctttggtc 1642321 ggcctatgtc tgggtttaat tgcttatatg atgattgccg cagtgcagat tgccggctcg 1642381 tttattgatt ttcaaatggg attttcaata gcaaacgtta ttgatccgca aaccggtgca 1642441 caaagtccgt tgattggcca gtttatctat acgatggcac ttttgtttat gctgagtgtc 1642501 aatgcccacc atttgttgct ggatggtatt tactacagct ttcagtatat ttcagttgat 1642561 caggcatttc cgaatttcgg cgatgaaaag tttgcctatt ttattgcgaa aagctttaat 1642621 gcaatgttta ttatcgcttt tcaaatgtca gcgccggttg tggccagttt gtttctagtt 1642681 gatttagcat taggtatcgt ggctcgaact gttccgcagt taaatgtatt tgtggtcggt 1642741 ctgcctttaa agatcgctgt cagtttcatt atgctcattg tatgtatgtc cgttatcttc 1642801 gtcgttgtcc ggaatgtttt cagtttaacg attgaaacga tgcggaatct tttagcattg 1642861 gtcggtgttt cttaatgaag cttagagttg acctgcagtt ttttgcggga gagaagacag 1642921 aaaaagccac tccgaaaaaa cggaaggata cgcgaaaaaa agggcaggta gccaaaagct 1642981 cggatgtcaa taccgccgtt tctttactgg taatattcct ttcgcttatt gcaattggtc 1643041 cgtatatgag agacaggctg ctgtcattca tagaaacatt ttataccgaa tcgctcacaa 1643101 tgaagctctc agaatcaaat gtgcatacat tgtttgtcag cttattaaag gatatgggca 1643161 tgatactcgc accgatcttg cttgttgctc ttgttgcagg agtcgtaagc aactatatgc 1643221 aggttgggtt cttgttttct gctgaagtga tacagcctaa gcttgaaaaa ctggatccga 1643281 tcaaaggctt taaacgaata tacagtatga gggcgattgt agagctgatt aaatcaattt 1643341 tgaaaatcgt agtcgtcggt tttgcggctt ttgctgtgct ttggctgcat tatggagaaa 1643401 ttctccggct tcctctcctg acacccgaag aggcactttc tttcgtttca aaactcactt 1643461 tgtggatggg actaagcggt gcaggtgcat tgttgattct tgctggtctc gactatttat 1643521 atcagagatt tgactatgag aaaaatatca aaatgtcaaa acaagatata aaagatgagt 1643581 acaaaaaatc tgaaggagac ccgattatca agtctaaaat taaacaaaga cagcgggaaa 1643641 tggcgatgag gcggatgatg caggaagttc caaaagcaga tgtcattatc acaaacccga 1643701 ctcactatgc gattgctttg aaatatgatg aagaaaaaat ggacgcacct tatattgttg 1643761 caaaaggcgt cgaccacctt gcgttaaaaa tcaggaaaat tgctaaagag catgatgtca 1643821 tgatggtaga aaacagaccg cttgcccgtg cgttatatga tcaagtggaa attgaccagg 1643881 cagtgccgga agaatttttt aaagttttag cagaaattct ggcttacgta tataaaacaa 1643941 aacaaaaagt atattgaatt tttcgattta aaaggagaga aaaaacagca tgtcaacaag 1644001 agatttatcc gttttaataa gtgttgtcct cattgtggcg atgctggtga ttccatttcc 1644061 tccatggctg ttaagtattt tgatcattat taatatttct cttgcgttga tcgtgcttct 1644121 caccacaatg aatatgcagg aagcgcttca gttttcgatt tttccgtcac tgttgctgct 1644181 tttgacccta tttcgtttgg gcttgaacgt ctcaactacc cgttcaattc tttcacacgg 1644241 tgagggaggt aaagtcgtcg agactttcgg aaatttcgtt gtcggcggaa atgtattagt 1644301 tggactcgtt gtatttatca tccttattat tattcagttt atcgtcatta caaaaggtgc 1644361 tgaacgtgtt tccgaggttg cagcaaggtt tacgctggac gcaatgccgg ggaagcagat 1644421 gagtattgat gctgatttaa acgcagggat gattaccgaa caggaagcga agcatcgccg 1644481 cgaaaaagtg gcaagagaag cagactttta tggagcaatg gacggtgcca gtaaatttgt 1644541 aaaaggtgac gccattgccg gaatcatcat tgtgatgatc aatattattt tcggaatcgt 1644601 gatcggaatg cttcagcagg gcatgtccat tcaagaagct gcttcacact ttacgatgct 1644661 gactgtaggg gatggaattg tttcgcaaat cccggcactg ttaatttcta cggctacggg 1644721 tattgtggtc acaagagctg catctgaagg aaacttaggg catgacatta caggccagct 1644781 gtttgcgtat ccaaagcttt tatacgtcgc agcagctacg atcatgcttt taggtatttt 1644841 cactccgatc ggcatccttc tgacggggcc gcttgcggga ttgcttgctt ttggcgcata 1644901 tacactatct aaatcaggta aggaaaaaga agaagtggat gagattcttg aggaagaggc 1644961 tgaggtggac gagcttaaaa gccctgaaag tgttgttcag cttctgcata tagatccgat 1645021 agaatttgag tttggatatg gcctgatacc gcttgctgat gccaatcaag gcggtgattt 1645081 attagaccga attgttatga tacgccgtca gttggctttg gaactcgggc ttgtcattcc 1645141 tgtcgtgcga atcagagata atatagcgtt gcagcctaat gaataccgat tgaaaattaa 1645201 aggaaacgaa gtagcaaaag gcgagctgtt gcttgatcat tatttagcga tgtcgcctac 1645261 tcctgaggac gatctcattg aagggattga aacagtggag ccttcattcg gactgccggc 1645321 taaatggatt agcgaagcgg taaaggatga agccgacatg cttggttata cagtagttga 1645381 tcctgcatca gtcgtttcaa cgcatattac ggagaaaatt aagcagcatg cccacgaatt 1645441 gatcggaagg caggagacaa aacagctgat cgatcacttg aaagaatcgt atccagtcct 1645501 ggttgaagag gttacgccga atccattgtc tgtcggtgat attcagaaag tgcttgctaa 1645561 gcttttaaaa gaaaaagttt caattcgaaa cttagtaacg atttttgaaa cacttgctga 1645621 ctatgggaaa ttaacaacag attctgatct cttgacagag tatacaagac aagcgcttgc 1645681 taaacaaatt acagcccagt ttgccaaaga aaatgaagtg ttgaaggttg ttacttgttc 1645741 cggccgtgta gaaaaagcaa tagcagacgg tgtgcagcag acggaacacg ggaactattt 1645801 atcacttgaa ccagatattt cagaaagtat agtgcgctct gtcgccaaag aagctgaaca 1645861 gctctcatta cgtcaggaaa ccgcgattct tctttgctcg ccgcctgtca gaatgtatgt 1645921 gaagcagcta ctggaacggt acttccctga tcttccggta ctctcttata acgaacttga 1645981 ggcgaatgtt gaggtacaaa gcattggagt ggtggatatt taatgaaaat aaaaaaattt 1646041 actgctgctt caatgcaaga agcggcactt ctcatcagaa aagagttagg taatgaagcg 1646101 gtcatattaa attcgaaaaa aattaaaaag cgaaaatggt ttggcctcgt caacaagcct 1646161 gctgttgaag taatcgccgt attggatcag gactttcttg agaaaaaaac gcctcagaag 1646221 gcagctgaac cgaaacaaac attaaaaact ccggtcagca gtccaaaaat agaggagaga 1646281 acatatcccc ctcaaattcc ggcgcaacag gagctaggtg atttttcagc atatcaatct 1646341 gtacttcctg agccgctgcg aaaagcagaa aagcttttgc aagaaacagg gatcaaagag 1646401 tctacgaaaa cgaacactct gaaaaaattg cttcgcttct ctgttgaagc aggcggcttg 1646461 actgaagaaa atgttgtcgg caaacttcag gaaatactat gcgatatgct gccctcagca 1646521 gacaagtggc aggagccaat tcattcaaaa tatatcgttc tctttggttc aacaggggct 1646581 ggtaaaacaa ctacactggc taaactcgca gccatatcta tgcttgaaaa acataaaaaa 1646641 atcgctttta ttacaacaga tacgtatcgt attgcagctg ttgaacagtt gaaaacatac 1646701 gctgaactgc tgcaggctcc tctggaagtt tgctatacaa aagaagaatt tcagcaggcg 1646761 aaggagctat tttctgagta tgatcatgtg tttgttgata cagctggaag aaacttcaaa 1646821 gacccgcaat acattgatga actgaaagaa acgattcctt ttgagagcag cattcagtca 1646881 tttcttgttt tatccgcgac tgcaaaatat gaagatatga agcatattgt caaacggttt 1646941 tcatccgtcc ctgtcaatca gtatattttt acgaaaatag atgaaacgac ttccttaggt 1647001 tctgtattta atatactggc agaatcaaaa ataggtgtcg ggtttatgac taacggccag 1647061 aatgtgcctg aggatataca gactgtatct ccacttggtt ttgtgaggat gctgtgcaga 1647121 tgaacagata tgaccaagca gcaactttac gggcgaaaat ggaaaaacgt gagcgcgttc 1647181 tgccaatggt ttattcacaa aaagcgaaga cacttgctgt catcagcggc aagggcggtg 1647241 tcggaaaatc caatattacc ttaaatatgg cacttgcgct gcaggataaa ggtaagaagg 1647301 tgctgctcat cgaccttgat atcgggatgg ggaacattga tatattaata ggaaattcat 1647361 cgtctgccac gataatcgat gttttaaccg atcgtaagcc tttgctgcag tcattatccg 1647421 ttggcccaaa gggtttgcgg tatatatcag ggggaaccgg tcttgatgtg atgtttcagc 1647481 tcgatcagag aaaatggacg ttttttgcca atgaactttc tcatgcatta agccagttcg 1647541 attatgtgct gtttgacatg ggagcaggct tatcaaaaga tcaactgcct tttattttat 1647601 cagcagaaga tattttgatt attacaactc ccgagccgac ggccattatg gacgcataca 1647661 gcgctgtcaa gcacttggtt ttgacagaaa ataagctttc aatgaaggtg gctgtcaatc 1647721 ggtgccgtga ccaaaaggaa gggcttgacg cttttgcccg cctctcccgt acaattcata 1647781 tgtttttgga tgttcaggtt cagtttgccg gttccgtttc tgacgatgtg atcgtgagca 1647841 aagcggttgt cgaacaggtt ccttttttca taaaaagccc tcaggcaaaa gccagccggt 1647901 cagtccgtat tttagcggac gccttgtttg aaagagaaga aacgagacac aaagaagaca 1647961 aacagacatt tattgagaaa ttatcttctt ttttaatgag gagggcttaa tttgattcgt 1648021 gtgcttgtag ttgatgattc agcttttatg agaaaaatga taagtgattt tctgaccgaa 1648081 gaaaagcaga tagaagtaat cggaactgcg agaaacggag aagaagcgct taagaagatt 1648141 gaattattaa aaccggatgt tattactctt gatgttgaaa tgccggtcat gaatgggaca 1648201 gatacgctcc gcaaaattat tgagatttat aacttgccgg tcattatggt gtctagccag 1648261 accgagaaag gtaaagaatg cacaattaat tgtttggaga tcggtgcctt tgactttatc 1648321 acaaagccat caggctcaat atctctggat ctatacaaaa ttaaagaaca actagttgag 1648381 cgtgtcgtcg cggcaggact ttccggcaag cggaaacgtc ctgtttccca gacagttcgg 1648441 cccgaaccta ttgtgcgtgc tgtcgttaag cctgaattaa gcaaaccgaa acctggcacg 1648501 ggcagacaaa ttgtgtgtat cggcacatca acaggcggtc cacgggcgtt acaaaaggtg 1648561 ataccgaagc tccctaagga tttgaacgca ccagtggttg tcgttcagca catgcctgaa 1648621 gggtttactg cttctttggc tgatcggctg aatcatttat ctgacattca ggtaaaagaa 1648681 gcaaaagatg gtgaagcagc tcttaacggc tgtgtttaca tagcaccggg cggaaaaaac 1648741 atatccgtta ttaaaaacag cgaaggactc caggttgtgc ttgataacca tgacacacca 1648801 agccgtcata aaccatctgc tgattattta ttccgttctg tcgggaaact gacagattat 1648861 gaaaaagtag cggttatcat gaccggaatg ggcagtgacg gcactgctgg actaaaggac 1648921 atgctaacag ccggcaatgt gaaagccatt gcggagtctg aagaatcttg tgtcgtatac 1648981 gggatgccaa aagctgctgt taaagcgggt ctcattcatg agattaaaca tgtggaagat 1649041 atcgcagcat ccatcacaag ctgtgtgaaa aaagagaggg tgtgattcaa atggatatga 1649101 atcagtattt agatgtcttt attgatgaga gtaaagaaca tttacaaaca tgtaatgaaa 1649161 agcttcttct tttagagaaa gacccgactg atcttcagct cgtacatgat atattcaggg 1649221 ctgcccatac attaaaagga atgagcgcaa cgatgggcta cacggattta gcacatctta 1649281 cccatctgct tgaaaacgtg ctggatgcaa tccgaaacgg agacatggaa gtcacctcag 1649341 actggctgga tattttgttt gaagctctgg atcacctgga aacaatggtt cagtctatta 1649401 ttgatggcgg ggatggtaaa agagatatct cagaagtgag tgccaagctt gatgtgaatg 1649461 gtgcgcacgc tgaatccgct gcctccgctg aacctgcaga agcacagagt tcagcatctg 1649521 attgggaata tgatgaattt gaacgcacag ttatacaaga agcggaggag caaggcttca 1649581 aacgatatga aatcaagatt tctctgaacg aaaactgtat gttaaaagca gttcgtgtct 1649641 atatggtgtt tgaaaaacta aatgaagtcg gagaagtagc caaaacaatt ccaagtgctg 1649701 aagtgcttga aacagaagat tttggaactg actttcaagt ttgtttctta acacatcaat 1649761 cagcggaaga cattgaacaa ttaatcaatg gcgtgtcgga aattgagcat gttgaagtca 1649821 ttcaaggggc tcctttaaca tcagctgaaa agcctgaaga atctaagcaa gaagattcac 1649881 cagcagcagc tgtacctgcg aagcaggaga aacaaaaaca gcctgctaaa aacgatgaac 1649941 aggcgaagca ttcagccggc ggatctaaaa caattcgtgt caacattgac aggcttgatt 1650001 ctttaatgaa cttatttgaa gagcttgtca ttgaccgcgg gcgtctcgag cagattgcga 1650061 aagagcttga gcataatgaa ctgactgaaa cggttgaacg aatgacgaga atttccggag 1650121 atttgcaatc gattattctg aatatgagaa tggtcccggt tgaaactgtt tttaacagat 1650181 tcccgagaat gattcgccag cttcagaaag agctgaataa aaaaattgaa ctctcgatca 1650241 tcggtgcgga aactgaactg gatcgtacag taattgatga aatcggagat ccactcgttc 1650301 acttgatcag aaacagtatt gaccatggta tcgaggcgcc ggaaacacgt ttgcaaaagg 1650361 gaaaaccgga atcaggaaaa gttgtgctta aagcttatca cagcggcaac catgtcttta 1650421 tcgaagtaga ggatgacggc gcaggcctta atcgaaaaaa aattctggaa aaagcgcttg 1650481 agcgcggggt cataacggaa aaagaagctg aaaccttaga agacaaccaa atttacgaat 1650541 tgatttttgc tccggggttc tcaactgctg accaaatttc tgatatttcc ggccgcggtg 1650601 taggacttga cgttgtaaaa aacaaactgg agtctcttgg cggttcagtc agtgtgaaat 1650661 cagccgaggg tcaaggctct ctattcagca tccagctgcc gcttaccttg tctattattt 1650721 cagttctgct gattaagttg gaagaagaga catttgccat tccgatttct tcaatcattg 1650781 agacagcagt tattgacaga aaagacattt tgcaaacgca tgaccgtgaa gtgattgact 1650841 ttagagggca tattgtccct gtcgtttatt taaaagaaga gtttaaaata gaagatacaa 1650901 gaaaagatgc ggaacagctc catatcattg tcgtgaaaaa aggcgacaaa cctactgcat 1650961 ttgtggtgga ctcctttatt ggccagcagg aagttgtgct gaaatcactc ggagattatt 1651021 taacaaacgt ctttgcaatt tccggagcta ctattttagg agacggagaa gtagcgctca 1651081 ttattgattg taatgcactg attatttaac cattcgagga ggtgtctcac atgactgcag 1651141 aaattaaaac aggcgaaaaa atgatagtct ttatggtaaa tggcaaagaa tatgccattt 1651201 ccgtcactca ggtgaaatca attgaaaaat ggcaaaagcc aacgagggta cctggcgtcg 1651261 aaccatatat ttgcggggta atcaatttac gcggggtggt gactccggtt attgatttaa 1651321 gaaaacgcct gaatttgcca gagtatgaaa ttacagatga aacacgaatt atcattattg 1651381 cttatcgtga tattgaagtc ggctggattg tggatgaagc gaatgatgtg attaccgtac 1651441 acgaaagtga aatagaatct gctccagaag gcgttcagaa agatacggat gtgtcgatcg 1651501 aacagattgt gaaacaagag aacagactct taaatattat tgatgcgaac gcggttttgg 1651561 ataaagaatc atctcagtcc gctgtgcccg atcaagctta atcttaaagg ggttatgaca 1651621 tgagtatttt taatggaatc aaagaagagc agatggacat tttgcgggaa gtcggcaata 1651681 taggcgccgg ccactccgcc tctgcaatgg cccagctgtt aaatagaaag atagatatgg 1651741 aagtcccatt tgcaaagctg ctgtcttttg atgagcttgt tgattttttc ggcggcgccg 1651801 atgtcccggt tgccagcatc tttttaagaa tggaaggcga tttaacgggt tcaatgttct 1651861 ttataatgcc tttttttcag gcggagcagt ttatcagaga gctgattgga aaccccgatt 1651921 ttgacataga ggacttaggt gaagaccaca tgagctcatc cgctttgcat gaactgggca 1651981 atattttagc ggggtcatat ttaacagctt tggcggattt gacgaaactc cagctctatc 1652041 caagtgttcc tgaagtctca ttggacatgt tcggagctgt gatcagcgaa gggctgatgg 1652101 agctcagtca ggttggagaa cacgccattg ttgtcgacac gtcaattttt gaccaaagcc 1652161 atcagcagga gctgaaagcg catatgttta tgctgccgga ctatgattca tttgaaaagc 1652221 tctttgtcgc cttaggtgca tcattatgag tacaactgag gctgttgtta taaaggttgg 1652281 gattgctgac gtgaagatcg cccgcttccc ggataccatc cggacctctg gtttgggctc 1652341 atgtgtgggg ctggtgcttt atgataaaga aaagcaaacg gcgggtcttg ttcatgtcat 1652401 gcttccggat tcgacgttat cgaaaactgc cgagctcaac cgggctaagt acgctgacac 1652461 cgccgtacag accacgattg atatgctgat agaagcggga tgccggaaat ttgcattaaa 1652521 agcaaagctg gccggcggat cagagatgtt taaatttaaa tcgacaaatg atttgatgaa 1652581 gatcggaccg agaaatgtat tagcgataaa agaacagctg tctttattta atattcctat 1652641 tattagtgaa gatacgggcg gctcaagcgg ccggacgata gaatttgaac cgaagtcctg 1652701 catgctgcat attcgaactg ttaaacaagg tgaaaaaacg atttaattaa ggtattaggg 1652761 ggataacaat gcaatccttg aattatgaag atcaggtgct ttggacgcgc tggaaagagt 1652821 ggaaagatcc taaagccggt gacgacttaa tgcgccgtta catgccgctt gtcacatatc 1652881 atgtaggcag aatttctgtc ggactgccga aatcagtgca taaagacgat cttatgagcc 1652941 ttggtatgct tggtttatat gatgcccttg aaaaatttga ccccagccgg gacttaaaat 1653001 ttgataccta cgcctcgttt agaattcgcg gcgcaatcat agacgggctt cgtaaagaag 1653061 attggctgcc cagaacctcg cgcgaaaaaa caaaaaaggt tgaagcagca attgaaaagc 1653121 ttgaacagcg gtatcttcgg aatgtatcgc ccgcggaaat tgcagaggaa ctcggaatga 1653181 cggtacagga tgtcgtgtca acaatgaatg aaggtttttt tgcaaatctg ctgtcaattg 1653241 atgaaaagct ccatgatcaa gatgacgggg aaaacattca agtcatgatc agagatgaca 1653301 aaaatgttcc gcctgaagaa aagattatga aggatgaact gattgcacag cttgcggaaa 1653361 aaattcacga actctctgaa aaagaacagc tggttgtcag tttgttctac aaagaggagt 1653421 tgacactgac agaaatcgga caagtattaa atctttctac gtcccgcata tctcagatcc 1653481 attcaaaggc attatttaaa ttaaagaatc tgctggaaaa agtgatacaa taatgaattt 1653541 catggttagc gagtgaaaaa catgtcaaca ctattatggc ttttaagctt tatgctccac 1653601 ggcgttcttc tgtacgctgt cattatcctg tatacgaggc tcgctgcagt gaaagaaaca 1653661 gaaaaacagc aaaaacagat acttgaagag acggaaaaca ccttggcggc atttctgctt 1653721 gaattaaaag aagaaaatga gaaactgata gaaaataaag cttcatctgc aagtcaatca 1653781 gatgaagaat cccaaaagtc aggccttcag acctctgaaa catatcaaga gcgggatcca 1653841 gtccaagagg cagagaatct tcctgaacat attgaaggtc tgattacaga ggttgaccgt 1653901 cgggaagagc tcgtaaacag tgaggtccaa tcatttgaag accaggtcat agaattatat 1653961 gaacagggat attcggcaag tcaaattgcc cagaaaatga agagcggaaa gacagaaatc 1654021 gagctatttt taaaatttcg ctccaaaggt gtaaaggatt cttgattgtc ggataaagct 1654081 gtgttatatt atgtcttggt gttaaataca cacgcttaac gatttatgca gagggtgctg 1654141 caggcggcag ttctgtacaa aaatgaccta agcggaggaa aaaaaccatt atattaggag 1654201 gaaataacat gtcagtcatt tctatgaagc aattgcttga agctggtgtt cacttcggtc 1654261 accaaacacg ccgttggaac ccaaaaatga agcgttacat tttcacggag cgtaacggaa 1654321 tctacatcat tgaccttcaa aaaacagtca aaaaagtaga ggaagcttac aacttcacta 1654381 aaaatcttgc tgctgaaggc ggaaaaatcc ttttcgtcgg aacaaaaaaa caagctcaag 1654441 attctgttaa agaagaagct caacgctctg gcatgtacta tgtcaaccaa cgctggttgg 1654501 gcggtacatt aacaaacttc gaaacaatcc aaaaacgtat taaacgtctt aaagacattg 1654561 aaaaaatgca agaaaacggt acgtttgatg tacttcctaa aaaagaagtc gttcaattga 1654621 aaaaagaatt agagcgtctt gaaaaattcc taggcggaat taaagatatg aaggatcttc 1654681 ctgatgcatt attcatcatc gatcctcgca aagagcgcat cgctgttgcg gaagctcgca 1654741 aattaaacat ccctatcatc ggtatcgtag atactaactg tgatccagat gaaatcgatg 1654801 ttgttatccc agcgaacgat gacgctatcc gcgctgttaa acttctaact tctaaaatgg 1654861 cagatgcaat cttagaagcg aagcaaggcg aagaagaagc ggaagttgct gaagaaactg 1654921 caccagaaac agaaacaaca actgcgtaac ctattcaaaa ggtgataaga gggactgcct 1654981 tttatcacct tttttcaaga aaaatgtgta atatacatac tcttgtttaa acatataagg 1655041 aggaatacaa atggcaatta ctgcacagca agtaaaagaa ctgcgtgaaa aaactggcgc 1655101 gggcatgatg gattgtaaaa aagcgttaac tgaaactgac ggagatatgg acaaagcaat 1655161 tgacctttta agagaaaaag gaattgcaaa agcagcgaaa aaagctgacc gtatcgcagc 1655221 agaaggttct actcttatta aaactgacgg caacaaaggc gttatcctag aagtaaactc 1655281 tgaaactgat ttcgttgcga aaaacgaagg ttttaaagag cttcttaaca ctttagctga 1655341 ccaccttctt gcaaacacgc cagctgatgt tgaagaagca atgggccaaa aaatggaaaa 1655401 tggctcaact gttgaagagt acatcacaag cgcagttgct aaaatcggtg agaaaatcac 1655461 tcttcgccgc tttacagttc ttacaaaaga cgacagctct gcattcggtg cgtaccttca 1655521 catgggcggc cgcatcggtg tattaactgt tctcaacggt acaactgatg aagaaactgc 1655581 gaaagatatc gcaatgcacg ttgctgcagt taaccctcgt tacatttctc gtgatcaagt 1655641 atctgaagaa gaaacaaatc atgagcgtca aatcttaact cagcaagccc tccaagaagg 1655701 caaacctgaa aacatcgtag cgaaaatggt tgaaggccgt ctgaacaaat tcttcgaaga 1655761 aatttgtcta ttagaccaag cgttcgttaa aaacccagat gaaaaagtga aacaagttat 1655821 tgcagcgaaa aacgctactg ttcaaacttt tgtccgctat gaagttggag aaggcatcga 1655881 aaaacgtcaa gaaaactttg ctgaagaagt aatgaaccaa gtgaaaaaat aatggtgaaa 1655941 agatttcgcg gctaagtcgc gtcttttcag gcagtatagg ggacacattt tgtgttccct 1656001 atttttaaaa ctatatttac aaaccttttt ttctcttgca taatagaaaa cggcaatgtt 1656061 tacacttgga ggttatcatg gaaaaaccaa aatacaaacg tatcgtatta aagcttagcg 1656121 gggaagcatt ggcaggagaa cagggaaatg gaattaaccc gactgtcatt caatccattg 1656181 caaagcaagt gaaggaaatc gctgagcttg aagtcgaagt ggctgttgtt gtaggcggcg 1656241 gcaacttatg gcgcggaaaa acaggaagtg acctgggcat ggaccgcgcg actgctgact 1656301 atatgggaat gctggcgaca gtaatgaatt cgcttgctct tcaagacagc ttggaaacac 1656361 tcggaatcca gtccagagtg caaacatcca ttgaaatgag acaagttgct gaaccgtaca 1656421 taagaagaaa agcgatacgc cacttagaga aaaaacgtgt cgttattttc gctgcgggca 1656481 caggaaaccc atatttctca actgatacga cagctgcact gcgggctgct gaaattgagg 1656541 cagacgttat tttaatggct aaaaataacg ttgacggtgt gtataatgct gatcctagaa 1656601 aagatgaatc agctgttaag tatgaatcac tttcttatct tgacgttctt aaagacggcc 1656661 tggaagtcat ggattcaaca gcttcctctt tatgcatgga caatgacatt ccgcttatcg 1656721 tcttttctat tatggaagaa ggaaatatca aacgtgccgt tatcggtgaa tcaatcggaa 1656781 cgatcgtgag ggggaaataa cgtgtcaaaa gaagtattaa ctcaaacaaa agaaaaaatg 1656841 gaaaaagcaa ttgctgctta tcagcgcgaa ttggctactg tacgcgcagg ccgtgcaaat 1656901 ccatcattat tagataaagt aacggttgaa tattacggag cgcagacacc tttaaatcag 1656961 ttgtcttcta ttaacgtgcc tgaagctcgt atgctcgtta tcacgccata cgataaaaca 1657021 gcaatcggtg atatcgaaaa agcgatttta aaagctgatt taggtcttac accaacaagt 1657081 gacggcaata tgattcgaat tgcaattccg gcactaacag aagagagacg gaaagaatta 1657141 gtgaaagttg taaaaaaata tgctgaagaa gcaaaagtag ctgttcgtaa cgttcgccgt 1657201 gatgctaacg atgatctcaa aaaacttgag aaaaacggag acattactga ggatgaactg 1657261 cgtgcttcca ctgaagacgt tcaaaaactg acagatgaat atgtgtcaaa aattgacagt 1657321 gtcacaaaag acaaagaaaa agaaatcatg gaagtttaat gaaaaactat gtacaataga 1657381 taatagtgaa aagaccctct catgtttaca gggggttttt ttgttaatac tgttgattac 1657441 attgattatc agcagggaat gtaacctttt tgggtgacgg aggaatctca tgctcaacat 1657501 actcaaaaat tggaagaatc agcaaactgc ggcttccaac ttagaacgtt atacaaaaga 1657561 agacatactt aagggagaaa ttcccgaaca catcgccatt atcatggatg gaaatggccg 1657621 ttgggctaaa aaacgctctc ttcccagaat tgcaggccac catgaaggga tgaaggtggt 1657681 aaaaaggacc acgaagctcg caaacgaatt aggtgtcaaa gtactgacat tgtatgcatt 1657741 ttcaacagaa aactggaaaa gaccgaaaat ggaggtcgat tttttaatga agcttccgga 1657801 agaatttttg aatacgtatc ttccagagct tgttgaggaa aatgtacagg ttcggatcat 1657861 tggggatgaa acggctttgc cggcgcacac attacgtgcg attgaaaaag ctgtacagga 1657921 cacggcgcaa aacgacggaa tgatccttaa ttttgctctt aactatggag gccgtactga 1657981 aattgtcagt gctgcaaaat cactcgcgga aaaagtgaag gaaggctctt tgaatattga 1658041 agacattgat gaatcgcttt tttctactta tttgatgact gaatctttgc aggatcctga 1658101 acttttaatt cgaacgagcg gcgagataag gctgagtaat tttatgctat ggcaggttgc 1658161 ctacagtgaa tttgtcttta ctgacgtctt gtggcctgac tttaaagaag atcacttctt 1658221 gcaggcgtta ggagagtttc agcagagagg ccggaggttt ggcggaattt agaggatggt 1658281 ggacatgaaa caaagaattt tgacaggtgt tctggcagca attgtatttt tatttttggt 1658341 tattgtcggg aaattgccgt tcaccatatt aatttatgct atgggcagtg tggcgctttt 1658401 tgaactttta cggatgaaaa agctgaagct ggtttcactg ccgggtttga tcggtctttt 1658461 attattgtgg atgttcttat taccaagcca gtattcgttt tttgaagcgg acgggatttc 1658521 caaaatggaa atcgctttat ttgcggtact gctattgctg acttacacag tgttggtcaa 1658581 gaacaccttt acttttgatg aagtcgggtt tattacgctt gcagcaattt acatcggaat 1658641 gtgttttcat tattttatcg aaatcagaaa tcttgaccaa tacggattaa catacatttt 1658701 ttatgcgtgt gttgtcattt ggtccaccga ttccggtgcc tattttgtcg gtaaatcgct 1658761 tgggaagcgg aaactgtggc ctgaaatcag tccgaataaa acagtggaag ggtttgcagg 1658821 cggaattgtc atcgcacttg tattggcgac gatttttcag cttgttgcac aacttccgat 1658881 cccgtatatc tatctgctgt tgatcacgct gtttttgtct gtttttggac aactgggaga 1658941 tttagtggaa tccgccttga aaagacatta cgatgtaaag gattctggga atattcttcc 1659001 cgggcatggc ggtatattag accgttttga cagtttcttg tttgtcatgc ctttcttgta 1659061 ctttctgctt gccctttttt cataaaaaag tctaatatga atatgagact gatcatgcag 1659121 caataagaat aggagtagtg gcaactttga aaaatatttg tcttttagga gcaacaggat 1659181 caatcggcga acagactctt gatgtactgc gtgcacatca agaccaattt cagctggtat 1659241 ctatgtcgtt tggcagaaat attgataagg ccgttccaat gattgaggtc tttcagccga 1659301 agtttgtctc tgtcggtgat ctggatacat atcataaatt aaaacaaatg tctttttctt 1659361 ttgaatgcca aatcgggctg ggagaagaag gactgataga agcagcagtg atggaggagg 1659421 ttgacattgt tgtcaacgct ttgcttggaa gcgtcggtct tatcccgaca ttaaaggcaa 1659481 ttgaacagaa aaaaacaatt gcgcttgcaa ataaggaaac tcttgtcact gcagggcata 1659541 tagtaaaaga acatgctaag aaatatgatg ttccgctgct gcctgttgac agtgagcatt 1659601 cagccatttt tcaagctctt caaggcgaac aggctaaaaa cattgaacgc ctcatcatta 1659661 cggcatccgg cggaagtttt cgggacaaga cgcgggagga gctcgaatca gtaacggttg 1659721 aagatgcatt aaaacatcca aactggtcaa tgggtgcaaa aattacaatt gattcggcta 1659781 caatgatgaa taagggatta gaggtgatcg aggcacactg gcttttcgat ataccttatg 1659841 aacaaattga tgtggtttta cataaggaga gcatcatcca ttcaatggtt gagttccatg 1659901 ataaaagtgt gatcgcacag ctcggaactc cggatatgag agtccccatt caatatgcgc 1659961 tcacttatcc tgaccgattg ccattaccag atgcgaaaag gcttgaatta tgggaaatcg 1660021 gcagccttca ttttgagaaa gctgattttg acaggttccg atgcttacaa tttgcttttg 1660081 aatcaggtaa aataggagga acaatgccga cagtgctaaa tgcggcaaac gaagtagctg 1660141 tcgctgcctt tttagctggc aagataccgt ttttggctat tgaagactgt atcgaaaagg 1660201 cactaacccg ccatcaatta ctgaaaaaac cgagcctggc ggacattcaa gaagtggaca 1660261 aagatacccg gggatacgtc aattcaatac tcacataagg tggtatgttc gtgaatacag 1660321 ttatagcgtt tatcattatt ttcggaacgc tcgttttctt ccatgaactg ggccatttat 1660381 tgctagccca aagagcggga attctctgcc gtgaatttgc gatcggcttc ggtccaaaga 1660441 ttttttcttt caaaaaaaat gaaacagttt atacgatcag gctgcttccg gtcggcggat 1660501 ttgttcgtat ggccggcgaa gatccggaaa tgattgaggt gaaacccgga tacacggtcg 1660561 ggcttctgtt taataaggaa gatcaagttg agaaagtcat catcaatcaa aaggaaaaat 1660621 atccggatgc tttagtcatt gaagtggaaa cagcggatct agagcatgac atgaagatca 1660681 ccggttatga acaggggaaa gaggacgaac tttccagctt tactgtcagc gaaacatcct 1660741 tttttattgt agacggagaa gaagtgcaga ttgcgccgta taatcgccaa tttggttcca 1660801 aacctgtatg gcagcggatt aaagcaattg ctgcagggcc gattatgaac tttattttag 1660861 cttacgtcat tttagtgatg cttgggctga ttcaaggcgt accgtcaaat gaacctatgc 1660921 tcgggcagct gacagacaat ggacgggcgg ctgaagcagg gctaaaagaa ggggattata 1660981 tccaaagcat taacggagag aaaatgaggt cttggactga cattgtctcc gctgtaaaag 1661041 aaaacccgga gaaagaaatg gacgttgcag taaaaagaga taacaaaacg cttcatattt 1661101 cggtgactcc ggaagctgtt aaagatgaga acaaaaaaac aatcggacgt ttcggttcct 1661161 atgcgccgac tgaaaaaggc gtactctcag cggttgctta cggcgcgaca tcaacagttg 1661221 atgtcaccaa agccatttta accaatctga gcaaattagt aacaggccaa tttaaactcg 1661281 atatgctgtc aggtcctgtc ggcatatatg acatgacaga ccaagtggcg aaaacaggga 1661341 tcgtgaactt atttcagttt gcggcgtttt taagcattaa ccttgggatt gtcaacctgc 1661401 ttccgattcc ggcacttgac ggaggaagac tgttgtttct atttattgaa gcgattcggg 1661461 gcaaaccgat taacagggaa aaagaagcat ttgttgtgtt tatcggagta gctttcttaa 1661521 tgcttcttat gctggttgtc acatggaacg atatccagcg gctgtttttg taaacgaaaa 1661581 gtaaatcaat cagaggtgcg aagaaatgag acaaagcttg acgcttattc ctacgctccg 1661641 tgaagttcca gctgatgccg aagcaaaaag tcatcagctt cttctgagag caggatttat 1661701 cagacagaat acgagcgggg tatacagcta tatgcctctt gcgtataagg tgattcaaaa 1661761 cattcagcag attgttcgag aggaaatgga gaaaattgat gccgtagaaa tgctcatgcc 1661821 cgcattgcag caggcagaga catggcagga atcaggcaga tggtatacgt atggtcccga 1661881 actgatgaga ctaaaagacc gtcatggccg tgaatttgct ttaggggcaa cgcatgaaga 1661941 ggttatcact tcgcttgttc gcgatgaggt taaatcttat aagcgtctcc ctctgactct 1662001 ttatcaaatt cagtctaagt tcagagatga aaaacgtcct cgcttcggtt tgttaagagg 1662061 ccgcgaattt attatgaagg atgcgtactc tttccatgca tctgcagaga gcctggatga 1662121 aacgtatcaa aaaatgtacg aggcctattc taatattttt gcccgctgcg gcattaatgt 1662181 aagacctgtt atcgctgatt caggcgcaat gggaggaaag gatacgcacg aatttatggc 1662241 actttctgcg atcggagagg atacgattgc gtattctgat gaatcacagt acgcggctaa 1662301 tatcgagatg gctgaagttc ttcaccagga agttccttca gatgaagagc ctaaagctct 1662361 agagaaggtt catacgccta acgtgaaaac aatcgaagaa ctgactgcgt tcttacaggt 1662421 ttcggctgaa gcgtgcatta agtcagtatt gtttaaagct gatgaccgtt ttgtcttagt 1662481 gcttgtaaga ggggatcatg aagttaacga tattaaagtg aaaaacttgc ttcatgcaga 1662541 agttgtagag cttgctacac atgaagaggt cattcagcag ctcggaacag agccaggctt 1662601 tgtaggccct gtcggtattc atcaggatgt ggaagtatat gccgatcaag ctgtgaaagc 1662661 aatggttaat gctgttgccg gggcaaatga aggagatcat cattataaaa atgtcaatgt 1662721 gaatcgtgac gcgcaaatta aagaatttgc tgatcttcgt tttattaaag aaggtgatcc 1662781 ttcaccagac ggcaagggaa cgatccgttt tgctgaggga atcgaagtcg gacaagtctt 1662841 taagctcgga acacgctatt cagaagcgat gaatgcgaca tatttagatg aaaacggacg 1662901 cgcgcagcca atgctgatgg gctgttacgg aatcggtgtg tcaagaacgc tttctgctat 1662961 tgctgaacag catcacgacg aaaaaggctt aatatggcca aaaagcgttg cgccgtacga 1663021 tcttcatatt cttgctttga acatgaaaaa cgatgggcaa agagagcttg ctgaaaagct 1663081 gtatgccgat ttaaaagcgg aaggctatga agtgctctat gatgaccgtg ctgagcgtgc 1663141 cggcgtaaaa ttcgctgatt cagatttaat cggccttcca atccgcatca ctgtcggaaa 1663201 acgagctgac gaaggaatcg tcgaagtgaa aattcgtcaa actggtgagt caactgagat 1663261 ttcagtagac gaattatctg cgtttatcag caagcagtaa tcaccataac gatttatcaa 1663321 aaaacatgtt aaaatagaaa taatagaagg tacctcattg cctgaggtac cttcacttat 1663381 gatgttttta gggagggata ctgtcttaat ggaacagtta tcagtaaaca gaaggcagtt 1663441 tcaaattctt ctgcagcaga ttaatatgac agatgatacc ttcatgacat actttgaaca 1663501 tggcgagatt aaaaagctga caattcacaa agcttctaag tcttggcatt ttcattttca 1663561 atttaaatct ttgctgcctt ttcaaatata tgacacatta acaacgaggc tgacgcaatc 1663621 gtttgcccac atagcaaaag tgacatcttc aattgaagtt caggatgccg aggtcagtga 1663681 aagtatcgtt caagactact ggtcacgctg cattgaagaa ctgcagggca tttcgccgcc 1663741 gattatcagt cttttaaacc agcaaaaacc gaagctgaag ggcaataaac tgattgtcaa 1663801 aaccaaaaca gatacagaag cggctgcgct aaagaacaaa tacagttcca tgattcaagc 1663861 agaataccgt caatttggct ttccggatct tcagcttgat gctgaaatat ttgtatccga 1663921 gcaagaagtt caaaagtttc gggagcaaaa gcttgcggaa gaccaagagc gggctatgca 1663981 ggccttgatt gaaatggaga agaaagataa agaaagtgat gaagaccaag caccatctgg 1664041 tcctcttgtt atcggttatc aaattaaaga taacgaggaa atccgaacac ttgacagcat 1664101 catggacgaa gaacggagaa ttacggtcca aggttatgtg tttgatgtgg agacgcgcga 1664161 gctgaagagc gggcgcacgc tgtgtatctt caaaattaca gactatacaa atagtatttt 1664221 gatcaaaatg tttgcacgtg aaaaagaaga tgcggcgctg atgaagtctc tgaaaaaagg 1664281 aatgtgggta aaagcacgcg gaagcattca aaatgataca tttgtcagag accttgtcat 1664341 gatcgcaaat gacgtaaacg aaataaaagc aaaaacccgt gaagattcag cacctgaagg 1664401 agaaaaaaga gtggaattgc atcttcattc cccaatgagc caaatggatg ctgttacggg 1664461 tatcggaaag cttgtcgaac aggcgaaaaa atgggggcat gaggccatcg ctttgaccga 1664521 ccatgctgtc gttcaatcct tccctgatgc gtattctgcg gccaaaaagc atggaattaa 1664581 aatgatttac gggatggaag cgaatctcgt ggatgatggc gtgccaattg cttataatgc 1664641 cgcacatcgt ctgctcgaag aagaaacata tgttgttttt gacgttgaga cgacaggatt 1664701 gtctgctgta tacgatacca ttattgagct ggctgcagta aaagtaaaag gcggagaaat 1664761 tattgataaa tttgaggcgt ttgcgaaccc gcatcgtccg ctttccgcca caatcataga 1664821 gctgacaggg atcacagatg atatgctaca agacgctccg gatgtcgtag atgtaataag 1664881 agatttcaga gaatggattg gcgatgatat tcttgtcgct cataatgcaa gctttgatat 1664941 gggattctta aatgtagcct ataaaaaact tcttgaagtc gaaaaagcta aaaacccagt 1665001 cattgatacg cttgaacttg gacgttttct ctatccggaa tttaagaacc accggttgaa 1665061 cacactttgt aaaaagtttg atatcgagct cacacagcat caccgtgcga tctatgatac 1665121 tgaggcaacc gcttatttgc ttctgaaaat gctgaaagac gcagctgaaa aaggtattca 1665181 gtaccatgat gagttgaatg aaaatatggg tcagtccaat gcttatcaaa gatcaagacc 1665241 gtatcatgca acattacttg ccgtgaacag cacgggactt aaaaatttat ttaagcttgt 1665301 gtcactttct catattcatt atttttacag agtgccgcgt attccgagat ctcagcttga 1665361 gaaatacagg gaagggcttc tgatcggttc tgcttgtgac aggggagagg tttttgaggg 1665421 aatgatgcaa aaatcgcctg aagaggtgga agatatcgcg tcattctatg attaccttga 1665481 ggttcagccg cctgaagtgt atcgtcactt gctggagctt gaactggtcc gtgatgaaaa 1665541 agcgctgaaa gaaattattg cgaatatcac gaagctgggg gaaaagctta ataaaccggt 1665601 tgttgctacg ggaaatgttc attacttgaa tgatgaggat aaaatctaca gaaagatttt 1665661 aatatcctca caaggcgggg caaatccgct gaataggcat gaactgccga aagtgcattt 1665721 cagaacgaca gacgaaatgc ttgaagcttt ttctttctta ggtgaagaaa aagcgaagga 1665781 gatcgtagtc accaataccc aaaaggttgc ttctttagtt gatgacatca agccgattaa 1665841 agatgattta tatacgccga aaatcgaagg cgctgatgaa gagatcagag aaatgagcta 1665901 tcagcgtgca agaagcattt acggggaaga gctgcctgaa attgtcgaag cgcggattga 1665961 aaaagagtta aagagtatta ttggccacgg atttgctgtt atttacttga tctctcacaa 1666021 acttgtaaaa cgttcactag atgacgggta tctcgttggt tcccgtggtt ccgtaggatc 1666081 ttcattagtt gcgacactta ctgagattac tgaggtaaac ccgctgccgc cgcactatgt 1666141 ttgtcctgag tgccagcatt ctgagttctt taatgacggt tctgtcggtt ctggttttga 1666201 cctgcctgac aagacatgcc ctcattgcgg aacgcctttg aaaaaagacg gccatgatat 1666261 tccatttgaa acgttcttag gatttaaagg ggacaaagta cctgatatcg atttgaactt 1666321 ctcaggggaa tatcagccgc aagcacacaa ttacacaaaa gtattgttcg gagaagacaa 1666381 tgtatatcgt gcgggaacaa taggcacggt ggcagaaaaa acagcctacg gttatgtaaa 1666441 aggctatgcc ggagacaaca atcttcatat gcgcggtgcc gaaatagatc ggctcgtaca 1666501 gggatgcaca ggtgtaaaac gtacaactgg acagcaccct ggcggtatta tcgtagttcc 1666561 ggattatatg gatatttatg atttttcacc gatccagttc ccggcagatg ccacaggttc 1666621 agagtggaaa acgactcatt ttgatttcca ctccatccat gacaacctgt taaaacttga 1666681 tattctcgga cacgatgacc cgactgttat tcggatgctt caagacttaa gcggaataga 1666741 tccgaaaaca attccgacgg atgatcctga agtgatgaag atcttccagg gaaccgaatc 1666801 actcggtgtg actgaagaac agattggctg taaaacgggc actcttggaa ttcctgaatt 1666861 cggaacccga tttgtccggc agatgcttga agatacaaag ccgaccactt tttctgagct 1666921 cgttcagatt tcaggcttgt ctcacggaac tgatgtatgg cttggcaatg cacaggagct 1666981 catccacaat aatatttgtg agctgagtga ggttatcggc tgccgtgatg acattatggt 1667041 ttatttaatc tatcaaggcc ttgagccgtc ccttgccttt aaaatcatgg aattcgtgcg 1667101 taaaggaaaa ggattaacgc ctgaatggga agaagaaatg aaaaataaca atgtcccaga 1667161 ctggtatatt gattcctgta aaaagattaa atacatgttc ccgaaagccc acgccgcggc 1667221 atatgtctta atggcagtcc gcattgctta ctttaaagtg catcatgctc ttttgtatta 1667281 tgcggcttat tttaccgttc gtgcagatga ctttgatatt gatacaatga tcaagggctc 1667341 tacagcaatc agagcggtaa tggaggatat aaacgctaaa ggacttgatg cttcaccgaa 1667401 ggaaaagaac cttctgactg ttttagaatt agcgcttgag atgtgtgaga gaggctattc 1667461 attccaaaaa gtcgatttat atcgctccag cgccacagag tttattattg acggcaacag 1667521 tcttattccg ccgtttaact ctattccagg gttagggacg aacgctgctt tgaacattgt 1667581 aaaagctcgc gaagaaggcg aattcctctc aaaagaagat ttgcaaaaga gagggaaagt 1667641 atcaaaaacg attttagagt acttagatcg ccatggctgt ctggagtcac tgcctgatca 1667701 aaaccaattg tcactgttct aatatggaaa gcagaatttc tcagaaattc tgcttctatg 1667761 catacataag cgcaaaaagt gccatcgtaa tattagagtt tctgtcactt gcttaggtat 1667821 gaaggtaagc gtatatccat ttgcaataaa aatatggtta tggtatagtt ttattggaaa 1667881 tgctaacgat taccgaggca aagagtgggg aaacccgctc ttttgtattg aacaggagaa 1667941 ttttgtctcg acatgttcat cgtttacttt ttagcccctg ctcttttgaa gcagggtttt 1668001 tatgcagagt gacgagacga atatgagatc gacagcacaa ggaggaagaa catgagcaaa 1668061 aaagtgactg acaccgttca agaaatggct cagccaatcg tagacagcct tcagctggaa 1668121 ctcgttgaca ttgaatttgt caaagagggc caaagctggt tccttcgcgt gtttattgat 1668181 tccgatgacg gtgtggatat tgaggaatgt gccaaagtaa gcgaagcttt aagcgaaaag 1668241 cttgatgagg cagacccaat cagccaaaat tactttcttg aagtctcatc tccaggagct 1668301 gagcgtccgc taaagaaaaa agccgatttc gaaaaatcac taggaaaaaa cgtatacatt 1668361 aagacgtatg agcctattga cggcgtaaaa gtgtttgaag gtgaactggc tgaatttgat 1668421 ggacaaacag tgacagttga gatcacgatc aaaacaagaa agaaacggat caatattccg 1668481 tatgaaaaga tagctaatgc aagattagct gttacattct aatgaataca aatgttttaa 1668541 ggggggagac cgttaaatga gcagtgaatt attagatgct ctcacgattc ttgaaaaaga 1668601 aaaaggcatc agtaaagaaa ttatcatcga agcaatcgaa gctgcgttaa tttctgctta 1668661 taagcggaat tttaatcaag cgcaaaatgt acgggtggat ctaaaccgtg aaactggctc 1668721 catccgtgta tttgcaagaa aagatgtcgt tgacgaagta tacgaccaga gattagaaat 1668781 ctcaattgaa gaggcacagg gcatccatcc ggaatatatg gtcggcgatg tcgtcgaaat 1668841 cgaagttaca cctaaggatt tcgggcgcat agctgctcaa acagcgaagc aggtcgtcac 1668901 acagcgtgtg cgcgaagctg agcgcggtgt gatttattct gaatttatcg accgtgaaga 1668961 agacatcatg acagggatcg tccagcgtct ggacaataaa tttatctacg tgtctttagg 1669021 caaaatagaa gccttgctgc cggttaatga gcaaatgccg aatgaaagct acaagcccca 1669081 tgaccgcatt aaggtatata tcacaaaagt agaaaaaaca acgaagggtc cgcagattta 1669141 tgtgtcaaga acacatccag gcctgttaaa gcgtttgttt gaaattgaag tgcctgaaat 1669201 ttatgatgga actgtcgagc taaaatctgt tgccagagaa gccggcgacc gttcgaaaat 1669261 ttctgttcgc acagatgatc ctgacgttga tcctgtcggt tcatgcgtag ggcctaaagg 1669321 ccagcgtgtg caagcaatcg tcaatgaatt aaaaggtgaa aaaattgaca ttgtcaactg 1669381 gtccagtgat cctgtagaat ttgtcgcgaa tgcgctcagc ccttccaaag tgcttgatgt 1669441 cattgttaat gaagaagaaa aagcgacaac tgttattgtt cctgattacc agctgtctct 1669501 ggcaattgga aaaagaggac aaaacgcacg cttagctgct aaactgacag gctggaagat 1669561 tgatattaag agcgaaacgg acgcaagaga acttggaatc tatccgagag aacttgaaga 1669621 agatgatgag ccgctcttta cggagcctga aactgctgaa tcggatgaat aagaggtgac 1669681 tttaggtgaa taaacacaaa aagatcccat tacgcaaatg tgtagtgact ggtgaaatga 1669741 agcctaaaaa ggaactgatc cgagttgtac ggtcgaaaga aggcgaaatc tcagtagacc 1669801 cgaccggaaa aaagaatggg cggggtgctt atttaacgct ggataaagag tgcatcttag 1669861 cagcaaaaaa gaaaaacact ttgcaaaatc aatttcaatc acaaatcgat gaccagattt 1669921 tcgatgaatt gctggaactg gcggaaaagg tgaaaaaata aaatgtctgg aatggaatgg 1669981 tttcccttgc tgggtctggc caatcgagct cgtaaggtcg tgtcaggcga agacttggta 1670041 ataaaagaaa tcaggaatgc gcgtgcaaag cttgtcctgc ttacagagga tgcatcatct 1670101 aacacagcaa aaaaagtaac tgacaagtgc aattattata aagtccctta taaaaaagtc 1670161 gagagtcgcg cggttcttgg acgctctatc ggtaaagaag cccgtgtcgt tgtcgccgtc 1670221 actgaccaag gttttgcgaa taagctgatc agcttgctcg attaatattt ttgggggtga 1670281 acgaatggct aaaatgagag tatacgaata tgcaaaagcg ttaaatgttt caagtaagga 1670341 aattttgacc gcactgaaga acatggattt agaagtgaat aatcacatgg ccatgcttga 1670401 agaaaaggcc attaaaaagc tagatgccaa atataaaaaa ggcggcgcag ctgctaaatc 1670461 tcaaaagcca gcagaaacga acaaaaacaa acagccacaa ggggttaatc agcaatcagc 1670521 tggaaatcaa ccaaataaaa ttcgagacgg aaagaagaat gacgtgcaga ataatcaatt 1670581 taacaaaaac aagaagaata acaacaacaa aaaaaataaa cgcaacaaca acaataataa 1670641 aaaccaacat cagcaaaagc ctgtaaagcc gaaaaaagag cttcctgaga aaattacatt 1670701 ctctggcact ttaacagttg gcgcacttgc tgaagagctt ggcaaagagc cttcagaact 1670761 cattaaaaag ctgatgcttc ttggcgtaat ggcaaccatt aaccaagagc ttgataaaga 1670821 cacaatcgaa ctcattgcat cagaatatgg tgttgaaaca gaagaggtca ttgtgcttga 1670881 agaaacagag ctggaaaaat acgaagagcc tgataatgaa gaggatcttg aaattcgtcc 1670941 tcctgtcgtg acaatcatgg gccacgttga ccatgggaaa acaacgcttc ttgacagcat 1671001 ccgtaaaaca aaggttgttg aaggggaagc aggcggaatc actcagcata tcggcgctta 1671061 tcaaattgaa gagaacggca agaaaatcac gttcttggat acaccgggcc acgccgcatt 1671121 tacaacaatg cgcgcacgcg gtgcagaagt aactgatatt acgattcttg tcgtagctgc 1671181 cgatgacggt gtcatgccgc aaacagttga agcgattaac catgcaaaag cagcagaggt 1671241 tccaatcatc gttgctgtga ataaaataga taaagaatcc gcaaaccctg accgtgtaat 1671301 gcaagaactg acggaatacg gacttgtccc tgaagcttgg ggcggagaaa ccatttttgt 1671361 gccgctttcc gctttaactg gaaaaggcat tgatgagctc gttgaaatga ttttgcttgt 1671421 cagtgaggta gaggaactga aagcgaatcc gaatcgtcag gcaaaaggaa cggttattga 1671481 agctgaactc gataaaggca gagggtcagt cgcgacgttg ctcgtacaga ctggaacact 1671541 gcatgtcggt gatccgatcg tagtcggcaa tacatttggc cgtgtccgtg caatggtcaa 1671601 cgacattggc cgccgtgtga aaactgccgg cccgtcaact ccggttgaaa ttaccggttt 1671661 gaatgatgtc cctcaagcgg gagaccaatt ccttgtcttt aaggatgaaa aaacagctcg 1671721 ttctgtcggt gaagcccgtg cttcgaaaca gcttgaagag cagcgcagcg ataaagcgaa 1671781 gctcagtctt gatgatttat ttgagcaaat taagcaaggt gatgtaaaag acatcaacct 1671841 catcgtaaaa gctgacgttc aaggatctgc tgaagcttta acggctgcac ttcaaaaaat 1671901 tgaagtagaa ggcgttaaag tgaaaatcat ccatacaggc gttggtgcga ttactgaatc 1671961 agacattatc ttggcatctg cttccaatgc aattgttatc gggtttaatg tgagaccgga 1672021 cggaaatgct aagagtacgg ctgaagctga aaatgtagat attcgacttc accgtatcat 1672081 ttacaaagta atcgacgaga ttgaagctgc catgaaaggt atgcttgatc ctgaatatga 1672141 agaaaaagta attggtcaag tagaagtacg ccaaacattc aaagtatcta aaatcggtac 1672201 aattgccggc ggatatgtta ctgaaggaac cattacgcgc gacagcggcc tccgtttaat 1672261 tcgtgacggc gtcgtcatct ttgaaggcga agtagatgtt ctgaaacgct ttaaagacga 1672321 tgtgaaagaa gtttcacaag gctatgaatg tggtattaca attaagaaat acaatgacat 1672381 tcgtgaaggt gacatccttg aagcgtttgt catgcaagaa attgaaagaa cgtgatcgga 1672441 tttgcggagt gtgaatgcat catttatgat gcaggatcgc taaaagaaaa gcgtgccgtt 1672501 ctgaagcgga ttttaaccag ggttcaaaac aagttcaatg tttcgatttc ggagattggc 1672561 tatcaggaca cctggcaaag aaccagcttc ggaatcgccg ctgtttcttc ctctcgcgtt 1672621 caaacagaaa aagaactgca gcgcgtccta gcgtttatcg attcttttcc tgaaattgaa 1672681 cggacgatca ctaggacaga gtggttttaa cttagaggtg attgaattga gtatgagagc 1672741 aaaccgtgtc ggcgagcaaa tgaaaaaaga actcggtgat attatcagcc gcaagctgaa 1672801 agacccgaga attggttttc tgacagtaac ggatgtacgt gtatcaggtg atttgcaaat 1672861 tgcaaaggtg tatatctcgg ttctcggtga cgagaaaaaa cgggaagaag cgctgaaagg 1672921 gctggcaaaa gcgaaaggat ttatccgatc cgaaatcggc agccgcatca gacttcgaaa 1672981 aacgcctgaa attgaatttg agttcgatga atcaatcgat tacgggaatc ggatcgaaac 1673041 actgattcac gaattacatt cagagaaacc atctgaataa aaaaagagag gataggcgta 1673101 tatcgtctgt cctctttctt cgtttataag aaaaaaactc aaaagaagga gtgaaaggca 1673161 aatggttaac ggagttctcc ttttacataa acctgttggc atgacatcgc acgactgtgt 1673221 catgaagatc cgaaagctgt taaaaacaaa aaaagtagga catacaggaa cgctcgatcc 1673281 ggaagtatca ggcgtgcttc cgatttgtgt aggaagagcg acaaaaatag tcgaatactt 1673341 aactgaaaaa tctaaaacgt atgatgcaga aataacattg ggcttttcaa ccacaacaga 1673401 ggatcaaacc ggagaaacgg tggaaacaaa gcctgtcaat cacgacattg ataaagcgga 1673461 tgtagaaaag gttttaaaca gtttaaaggg gaaacaagaa caaattccgc ccatgtattc 1673521 cgctgtaaaa gtaaacggca aaaaattata cgaatacgca agagcaggga ttgaagtaga 1673581 acgtccgaaa cgtatgataa ccattgaaga cattgccctg acaacagaga ttaaacatca 1673641 tggagaaacc gcaagcttcc ggtttacagt gacttgctcc aaagggacct atgtaaggac 1673701 gctggcggtc atgatcggag aaaagctcgg atatccggcc catatgtctc atttaatccg 1673761 tacggcatcc ggagattttt ctctcgacga atgctttact tttgatgaac tcgaagcaca 1673821 ggcccaatcc ggaaccgtgg aagagcatac agttcctatt gaacgtgcgc tcaatcattt 1673881 gccgaaatgg atcataagtg atacattagc taagaaagta gaaaatgggg ctttgcttga 1673941 gacgcccgag cagttttctg aaatgacaag tggagaccgt attgccgtct ttactgaatc 1674001 cggaacctgc ttggcgatct atttccctca tcctgcaaaa aaagggctgt taaagccggc 1674061 aaaagtattg atgcaaaaaa gcgaacaata gaaaaaaggt gaccgttctg tgaagacgat 1674121 acatattaca catcctcatc atttaataaa agaggagcag gcaaaatcag tgatggcgtt 1674181 aggttatttt gacggcgttc atctcgggca tcaaaaggta atcggcacag cgaagcaaat 1674241 agccgaagaa aaaggtctga cattagctgt gatgaccttt catccccatc cttctcacgt 1674301 gttgggcaga gataaggaac caaaggatct gattacgcct cttgaagaca aaataaacca 1674361 aattgaacaa ttaggcacag aagttctgta tgtcgttaaa tttaatgaag tgtttgcttc 1674421 tctttctcct aagcagttta tagaccagta tattatcggc cttaatgtgc agcacgcagt 1674481 ggcaggcttt gactttacgt acggcaaata cggcaaggga acaatgaaga ccatgccgga 1674541 tgatttagac ggaaaagctg ggtgcacaat ggtagaaaaa ttaacggagc aggataaaaa 1674601 aatcagttct tcgtatatcc gtaccgcgct tcaaaacgga gatgttgaat tggcgaatgt 1674661 cttgcttgga caaccttatt ttattaaagg aattgtcatt catggtgata aaagagggcg 1674721 gaccatcggg tttccgacag cgaatgtcgg tttaaataac agctatatcg ttccgcccac 1674781 aggtgtatat gccgtaaaag cggaagtgaa cggcgaagtt tacaatggcg tttgcaatat 1674841 tggctataag ccaacgtttt atgaaaagcg ccctgaacag ccttccatcg aggtcaatct 1674901 gtttgatttc aatcaagagg tatatggagc cgctataaaa atcgaatggt acaaacggat 1674961 tcggagcgag cggaaattca atggcatcaa agaattaact gagcaaattg agaaagataa 1675021 gcaggaagcc atccgttatt tcagcaattt gcggaaataa cttgcaacgc acgcaaattt 1675081 tattctaaaa tatttgcata taggcacgat ttttagtatg atagttttcg tagtcttaaa 1675141 accattgctt ggcaatccga agtcaccgac ggttgctagg taactggggc taaatatgat 1675201 ttggaggtga aacaggatgg caattactca agagcgtaaa aaccaactca tcaatgagtt 1675261 caaaacacac gaatctgata ctggatctcc agaagttcag atcgctatcc taactgactc 1675321 aattaacaac ttgaacgagc atttacgtac tcacaagaaa gaccaccact cacgtcgcgg 1675381 tcttcttaaa atggtaggta agcgtcgtaa tcttcttacg tatctgcgta ataaagacgt 1675441 aactcgttac cgtgagttaa ttaacaaact aggcttacgt cgataatcgt aaaaagcggg 1675501 aggattcccg cttttttatc gtattaaagc gaaatttctt ataacaaatc attgaaatcc 1675561 ttttacatac tactttgaca ttgatatgtt caattcattt cgttcataat aggagtaatt 1675621 gattatttca cacaacgaag agaggagttc gtaattgtat gggacaagaa aaacatgtct 1675681 ttaccataga ttgggccgga agaacgctta ccgttgaaac cggccagctt gccaaacagg 1675741 caaatggtgc tgtgatgatc cgctacggtg atacagcagt acttagtaca gcaaccgctt 1675801 caaaagaacc taaaccgctt gatttcttcc ctcttactgt aaactatgaa gaaagattat 1675861 atgcggtagg gaaaattccg ggcggattta ttaaaagaga aggacgtcca agtgaaaaag 1675921 cggttcttgc cagccgttta attgaccgtc cgatccgtcc tttgtttgcc gatggattcc 1675981 gtaatgaagt tcaagtcatc agcattgtca tgagtgttga ccaaaactgc tcttcagaaa 1676041 tggctgccat gttcggttca tctcttgcac tttctgtatc ggatattccg tttgaaggac 1676101 cgattgcagg ggttactgtc ggacgcattg atgatcaatt tatcattaac ccgacagtcg 1676161 atcagcttga aaaaagcgat atcaatcttg tcgttgccgg cacgaaagat gcgattaaca 1676221 tggtagaagc gggagcggac gaagttcctg aggaaatcat gcttgaggcc attatgttcg 1676281 gccatgaaga gattaaacgc ctgattgcat tccaagaaga aattgttgca gcagtcggca 1676341 aagagaaatc tgaaattaag ctctttgaaa ttgatgaaga gcttaatgaa aaagtaaaag 1676401 ctttggcaga agaggatctg ctgaaagcca tccaagttca tgaaaagcat gcccgtgaag 1676461 atgccattaa cgaagtgaag aacgcagttg tggcaaaatt cgaggatgaa gaacatgatg 1676521 aagacacaat caagcaagtg aagcagattt tatccaagct tgtgaaaaat gaagttcgcc 1676581 gcctgattac tgaagagaaa gtaagaccgg acggccgcgg tgtcgatcaa atccgtccgc 1676641 tctcttcaga ggttggcctc ttgccaagaa cgcacggttc aggtctattt acaaggggac 1676701 aaactcaggc cctcagcgta tgtacgctag gtgctctggg agatgtgcaa atccttgacg 1676761 gcttaggtgt cgaagagtcg aaacggttta tgcatcatta caacttcccg caattcagcg 1676821 ttggggaaac aggaccgatg cgcggaccgg gacgtcgtga aatcggacac ggagcactgg 1676881 gtgagcgtgc gcttgagcca gttattccgt ctgaaaaaga cttcccttat actgtccgtc 1676941 ttgtttcaga agtgcttgaa tcaaacggtt ctacatctca agcaagcatt tgcgcaagca 1677001 cacttgcaat gatggatgcc ggtgtaccga ttaaagcgcc agttgctggt attgcgatgg 1677061 gtcttgtcaa atcaggcgaa cattacactg tcttgactga catccaaggc atggaagacg 1677121 cgctcggaga tatggacttt aaagtagcgg gaactgaaaa aggcgtaacg gccctgcaaa 1677181 tggacattaa aattgaaggc ctttccagag agattcttga agaagcgctt cagcaggcga 1677241 aaaagggcag aatggaaatc ctcaacagca tgcttgcaac attaagcgaa tcaagaaaag 1677301 agctttctcg atatgcgcct aagatcttaa caatgaccat taatcctgat aaaatccgcg 1677361 atgtcatcgg accaagcggg aaacaaatca ataagatcat cgaagaaacc ggtgttaaaa 1677421 ttgatattga gcaggacggc acaatcttta tttcctctac agatgaaagc ggcaaccaaa 1677481 aagcgaaaaa aatcatcgaa gaccttgtga gagaggttga agtcggccaa ctttacctag 1677541 gtaaagtgaa acggattgaa aaattcgggg ctttcgttga aattttcagc ggaaaagacg 1677601 gtttggtgca catttcagag cttgcgcttg aacgcgtagg gaaagttgaa gatgttgtga 1677661 aaatcggaga cgagattctt gtcaaagtca ctgaaattga taaacaagga cgagtgaatt 1677721 tatcccgcaa agcggtgctc cgtgaagaga aagaaaaaga agaacaacaa tcttaaatga 1677781 aaacataaaa ggagcctggg agacccggct tctttatttt gaagcttttc aaaagcaggc 1677841 gggttctacc ttgtccttct ccttcataat gtgaggtgag ggggggacag aacatgtaca 1677901 aaaaatttgt accgtttgcc gtttttttat ttcttttttt tgtctcattt gagatgatgg 1677961 aaaatccgca tgcacttgat tatatagggg caatgaaaaa agatacggtg actgtcacgg 1678021 cgtcaaaaga cccgttatat gaagaattgc ttcaaaaagc gccggagtac gaagttaagc 1678081 cccagaatgc aagaattgat aaagtgtgga aaagcattcc aggctacaat ggattaaagg 1678141 tcaatattga acaatcatat aaaaaaatga aacagcatgg taagtttcgg gaaaaagatt 1678201 tggtgtacag tcaagtaaaa ccaagtgttc atcttgagtc acttcagcct gagcctattt 1678261 ataaaggaaa tcctgacaaa ccgatggtgg cttttttaat caatgtggca tggggaaatg 1678321 agtatttgga aaaaatgctt cctattctgc aaaagcacca ggttaaagct acgttctttt 1678381 tagaaggcaa ttgggtgaga aacaatgtac agctcgctaa gaagattgca aaagacggac 1678441 atgaaatcgg aaatcattca tacaatcatc cggatatgag caaactgact acaggaagaa 1678501 tttccgagca gctcgacaag actaatgaac aaatagaaca aacgatcggc gttaagccaa 1678561 agtggttcgc tccgccaagc ggaagtttca gaaaagcggt tatcgacatt gcagcagaga 1678621 aacagatggg aacagtcatg tggacagttg atacaatcga ttggcaaaag ccggctccgt 1678681 ctgtacttca gacgagagtg ttaagcaaga tacataatgg tgccatgatt ttaatgcatc 1678741 cgactgaccc tacggcggaa agtcttgaag cgctgattac acagataaaa gacaaaggat 1678801 atgcgcttgg aacagtcact gaactaatgg atgaaacaag actattgaag taacagatga 1678861 aggcagcttg tctttgaata ggaggaacaa atttgattaa acgatatacg tgtcaaaatg 1678921 gtgtaagaat tgtgctggaa aataacccga cagtccgttc tgttgcgatc ggcgtatgga 1678981 tcggcacagg ttcgagacat gaaacgccgg agataaacgg aatttctcac tttttagagc 1679041 acatgttctt taaagggacg agcacaaaat ctgcacgcga gatagcagaa tcttttgatc 1679101 gtattggcgg ccaggtcaat gcgtttactt caaaggaata tacctgctac tatgcaaagg 1679161 tgcttgacga gcatgcgaat tacgcgctgg acgtattagc agatatgttc tttcattcaa 1679221 cgtttgatga aaacgagctg aaaaaagaga aaaatgtagt atatgaagaa attaaaatgt 1679281 atgaagatgc gccggacgac attgtacatg atttattgag caaagccact tacggcaatc 1679341 attctttagg ctacccaatt ttaggaacgg aagaaacgct tgcttccttt aacggtgact 1679401 ctctcagaca atacatgcat gattattata cgccggaccg agtggtgatt tcggtagcgg 1679461 gcaatatatc tgacagtttt atcaaagatg tagaaaaatg gttcgggtca tacgaggcga 1679521 aaggcaaagc gacaggcctt gagaagcctg agttccacac ggaaaaactg acgagaaaaa 1679581 aagaaacaga gcaggctcat ttgtgccttg gatttaaagg cttagaggtt ggccatgaac 1679641 gtatttatga tttaatcgtc ctcaacaatg tgctcggagg cagcatgagc agccggctgt 1679701 tccaagatgt gcgtgaagat aaaggacttg cttattctgt ttacagctat cacagctcat 1679761 atgaggacag cggaatgcta acgatttacg gcggaacggg tgcaaatcag cttcagcagc 1679821 tgtcggaaac aattcaagaa accctggcca cattaaaacg tgacggcatt acctcgaaag 1679881 aactggaaaa cagcaaagag caaatgaagg gaagcttaat gctgagctta gaaagcacaa 1679941 acagcaaaat gagccgaaac ggaaaaaatg aactgctgct cggcaaacat aaaacattag 1680001 atgaaattat caatgaatta aacgccgtga acttagagcg tgttaatggc cttgccagac 1680061 aattgtttac cgaagactat gcattagcac ttatcagccc ttccggcaat atgccgtctt 1680121 aaaaaggaaa gcctgcccca taatggagca ggcatttttt aatccctttc atcatacata 1680181 gtacaagggg gtgacagaca tgcggctcag tgaattatcg ggaaaggaaa ttgtagacat 1680241 caaaagagct gaacggctcg gagtgctcgg ccagaccgat ttggaaatca atgaacagga 1680301 tggacagatt acagcactcc tcattcccac agttaagtgg tttggtttga gaaagcaagg 1680361 tcatgacatt cgtgtcccat ggcaccatat tcaaaagatc ggttcagata tgattatatt 1680421 agatgtacct gaggaaatgc ctcctcgaca agagtaaata gcccaattga ctgtgaagcg 1680481 ggctctaaag aaaacatctg aaacatcggc tgccggagcc gatgtttttt tatatggaaa 1680541 aagcgcatct tttatattca ccggtatttc cttttgatca taagatgaag gggagcttaa 1680601 caactagaga tccagtatat acaaagaagg tgaacgttta gaatgttaac cggattgaaa 1680661 attgcagtta tcggcggtga cgcaagacag ctcgaaatta taagaaagct cactgaacag 1680721 caggctgaca tctatcttgt cggttttgac caattggatc acggttttac cggggcagta 1680781 aaatgcaata ttgatgaaat tccttttcag caaatagaca gcatcattct tccagtatcc 1680841 gcgacaacag gagaaggtgt cgtatcgact gtattttcga atgaagaagt tgtgttaaaa 1680901 caggaccatc ttgacagaac gcctgcacat tgtgtcattt tctcaggaat ttctaacgcc 1680961 tatttagaaa acattgcagc tcaggcaaaa agaaaacttg ttaagctgtt tgagcgggat 1681021 gacattgcga tatacaactc tattccgaca gtagaaggaa cgatcatgct ggctattcag 1681081 cacacggatt atacgataca cggatcacag gtggccgttc tcggtctggg gcgcaccggg 1681141 atgacgattg cccgtacatt tgccgcgctc ggggcgaatg taaaagtggg ggcaagaagt 1681201 tcagcgcatc tggcacgtat cactgaaatg gggctcgttc cttttcatac cgatgagctg 1681261 aaagagcatg taaaagatat agatatttgc attaatacca taccgagtat gattttaaat 1681321 caaacggtac tttctagcat gacaccaaaa accttaatat tggatctggc ctcacgtccc 1681381 gggggaacgg attttaaata tgccgagaaa caagggatta aagcacttct tgctcccggg 1681441 cttccaggga ttgtcgctcc taaaacagct gggcaaatcc ttgcaaacgt cttgagcaag 1681501 cttttggctg aaatacaagc tgaggagggg aaataaggat gtcgtcatta aaaggaaaaa 1681561 gaatcgggtt tgggctgacc gggtcgcatt gcacatatga agcggttttc ccgcaaattg 1681621 aggagttggt caacgaagga gctgaagtcc gtccggttgt cacatttaat gtaaaatcta 1681681 caaatacccg atttggagag ggcgcagaat gggttaaaaa aattgaagac ctgactggat 1681741 atgaggccat tgattcgatt gtaaaggcag aacctcttgg gccgaagctg ccccttgact 1681801 gcatggtcat tgcgccttta acaggcaatt caatgagcaa gctggcaaat gccatgacgg 1681861 acagcccggt gctgatggcg gcaaaagcga caatccggaa caatcggcct gtcgttctgg 1681921 gtatctcgac aaatgatgct cttggtttaa acggaacaaa tttaatgagg ctcatgtcaa 1681981 caaaaaatat cttttttatt ccattcgggc aagatgatcc atttaaaaaa ccgaattcaa 1682041 tggtagccaa aatggatctg cttccgcaaa cgattgaaaa ggcactcatg caccagcagc 1682101 ttcagccgat tctagttgag aattatcagg gaaatgacta aatttacaga aaatctttcc 1682161 caaactaaaa aattcggtca tcacccgcat attctatggt aaaataaaac gtaaaatcat 1682221 agtcaaatca attcaatgaa gctgattggc ggaaggagtt ttacagatgg gaagaggttt 1682281 acacgtagct gttgtcggag cgacaggggc tgtgggacaa caaatgctta aaacacttga 1682341 agacagaaac tttgaaatgg acacacttac attgctatct tcaaaacgct ctgcggggac 1682401 aaaagtcacg tttaaaggcc aagagctgac tgttcaggaa gcttctcctg agagctttga 1682461 aggggtaaat attgctttgt tcagcgccgg cggaagcgta tcacaagcat tggcaccaga 1682521 agctgtaaaa cgcggcgcta ttgttataga taatacgagt gcgttccgca tggatgaaaa 1682581 tacaccgctt gttgtgccag aagtgaatga ggcagacttg catgaacaca acggcattat 1682641 tgccaatcca aactgctcta caatccaaat ggttgcggca cttgaaccga tccgcaaagc 1682701 atatggctta aacaaggtca tcgtatcaac ttaccaggca gtatcaggag cgggtaatga 1682761 agctgtaaaa gagctttaca gccaaacaca ggcgatttta aataaagaag aaatagagcc 1682821 tgagatcatg cctgtaaaag gtgacaaaaa acactatcaa atcgccttca acgcgattcc 1682881 gcaaatcgat aaattccaag ataacggcta tacgtttgag gaaatgaaaa tgataaatga 1682941 aacgaaaaaa atcatgcaca tgcctgacct tcaagtagcg gctacatgtg tgagactgcc 1683001 aatccaaact gggcactcag agtccgtcta catcgaaata gaccgtgatg acgctacagt 1683061 tgaagatatt aaaaatctat tgaaagaagc tccgggcgtg acacttcagg atgatccaag 1683121 ccagcagctt tatccgatgc ctgctgatgc tgtcggcaaa aacgatgtgt ttgtaggccg 1683181 catccgcaaa gacttggaca gagcaaacgg ttttcattta tgggttgttt ctgataacct 1683241 attaaaaggc gcggcatgga actctgttca aattgcagaa agcctgaaaa aactaaacct 1683301 cgtataaaag agagaatttt ctaaagacga atagaagaga gtaaggcgct atcagcctgc 1683361 tctcttctgt tacgtccgaa taatttggag tgaaaacagt gaagataatt gttcaaaagt 1683421 tcggcggaac atcagtaaaa gatgataaag gccgcaaact ggctttaggg catattaaag 1683481 aagcaatcag tgaaggatat aaggttgtcg ttgtcgtttc agcgatgggc cgaaaagggg 1683541 acccgtatgc aacagattct ttgctcgggc tgctttacgg cgatcagtca gcgatttctc 1683601 ctagggagca ggatttgctt ttatcttgcg gagagactat ttcctctgtc gtctttacaa 1683661 gcatgctgct tgataacggt gtgaaagcag ctgcgctgac aggggctcag gctggctttt 1683721 taacgaatga tcagcatact aatgcgaaaa tcattgaaat gaaaccggag cgtttattca 1683781 gtgtgctcgc caatcatgat gcggtagtcg tcgcaggctt ccagggcgca actgaaaagg 1683841 gtgatacaac aacaatcggc agagggggca gcgatacgtc tgcagccgca ctcggagcag 1683901 ctgttgatgc ggaatacatc gatattttca ccgatgtaga aggcgtgatg actgctgacc 1683961 caagagtggt agaaaatgca aaaccgcttc ctgttgtgac gtatacggaa atctgcaacc 1684021 tggcgtatca gggggccaag gtcatttctc cgcgtgctgt ggaaatcgca atgcaggcca 1684081 aggttccgat ccgcgtccgt tcgacttatt cgaatgataa aggcacattg gtgacatcac 1684141 atcactcttc caaggtcggc agtgatgttt ttgaaaggct gattacggga atcgcccatg 1684201 tcaaagatgt cacgcagttc aaagtgcctg cgaaaatcgg ccagtataac gttcagactg 1684261 aagtgttcaa ggctatggca aacgctggaa tcagtgtcga tttctttaac attacaccta 1684321 gtgaaatcgt ctatacggta gccggaaata aaacagaaac agctcagcgt attttaatgg 1684381 atatgggcta tgatccaatg gtgacgagaa actgcgcgaa ggtatcggcg gtcggcgcgg 1684441 gcattatggg tgttcccggt gttacgtcca aaattgtatc ggctctttca gaaaaagaaa 1684501 ttccgatcct tcagtcggct gacagccata cgacgatatg ggtgctcgtc catgaagcgg 1684561 atatggttcc tgctgtaaac gctttgcatg aagtgtttga actttcgaag taaatgtgat 1684621 tgaatcatga tgaggtgaat aaaatgaatt tcggaaatgt gtctacagcg atgattacac 1684681 cctttgacaa taaagggaac gtagactttc aaaaactgtc tacactgatt gattacttgt 1684741 tgaaaaacgg aacggattct ttagtagtag cgggaacaac tggagaatct ccgacccttt 1684801 caactgaaga aaaaattgcg ctttttgaat atacggtaaa agaagtaaac ggacgggtgc 1684861 ccgttatcgc tggtactggg agcaacaaca cgaaagattc cattaagctg acaaaaaaag 1684921 ctgaggaagc gggcgtggac gctgttatgc ttgttacccc gtattacaat aaaccttctc 1684981 aagaaggaat gtaccagcat tttaaagcaa ttgcggcaga gacatctctt ccggttatgc 1685041 tctataatgt tcctggccgt acggttgctt ctcttgctcc tgaaacgacg atccgtttgg 1685101 cggcagacat tccgaatgtg gttgcgatta aagaagcgag cggagacctc gaagcgatta 1685161 caaaaattat tgctgaaaca cctgaagact tctatgtcta ttcaggggat gatgctctaa 1685221 cgcttccaat tctttcagtt ggaggtagag gagttgtgtc agtggcgagc catattgcag 1685281 gcactgatat gcagcaaatg atcaaaaatt atacgaatgg gcaaacagct aatgcggcac 1685341 tgattcatca gaaactgctg ccgattatga aggaactgtt taaagcgcct aatcctgctc 1685401 cagtcaaaac agcgcttcag ctgagaggtc ttgatgtcgg ttctgtgcgt ctgcctctag 1685461 tcccattaac tgaggatgaa cgtctgagct taagcagcac gatcagcgaa ctgtaagaaa 1685521 atttcataca gtgaaacaaa cgcggtcatt ctcacattca gctgagtttg accgtttctt 1685581 ttacatattg gttttcccta aaccttctgc tttatcttgt tttctaaatt tactttcagt 1685641 tataatagga acaagtgatg atggacgggt atgagactag gaggatatag attttgaaaa 1685701 agaaaaatac agaaaacgtt agaattatcg cccttggcgg tgtcggagag attgggaaga 1685761 acctttatgt cattgaaatt gactcagaca tatttgtcgt tgatgccggc cttatgcatc 1685821 cagaaaacga aatgctcggt attgatgtag tgattcctga catatcatat ttgattgaac 1685881 gggctgaccg cgtcaaggca atctttttaa cgcacgggca cgatgaaaat atcggcggcg 1685941 ttttttactt attaaacaag ctgtccgttc cagtgtacgg aacaaaactg acgcttgcac 1686001 tgttaagaga gaaattaaaa caatacggac ataaccgaaa aactgattta agagaaattc 1686061 actccaaatc tgtcattaca tttgaatcaa caaaggtatc gttctttaga acgattcaca 1686121 gcattcctga ttctgtaggt gtgagcttta aaacatcact tggatctatt gtatgcacgg 1686181 gagacttcaa atttgaccaa acacctgcac ttaatcagac gtgcgacatt ggcgagatcg 1686241 ccaagatcgg caatagcggc gtgctcgctc tgctttctga cagtgcaaat gcggaacggc 1686301 cgggttacac cccttcggaa gcggctgtca gcggagaaat ttcggatgcg ctgtataatt 1686361 cacagaaccg ggtgattatt gctgttttcg catccaatat taaccggatt cagcaagtca 1686421 ttcatgcagc ggctcaaaat ggcagaaaga ttgccgtagc cggaaaaaat cttcaatctg 1686481 tcctgcagct ggcgagaaag ttaggatata ttgaagcaga tgatgaattg tttatttctg 1686541 tacaggatgt caaaaaatat ccgaagcgcg aagtggccat tattacagcc ggaagccaag 1686601 gtgaaccatt agctgctttg acaagaatgg caaacaaagc tcacaaacag ctgaacattg 1686661 aagaagggga tacggtggtc attgcgtcaa ctccgattcc cgggcaggaa ctcatttact 1686721 ctaaaacagt agatcttctt gcgagagccg gtgcacaagt catctttgcc caaaagcgtg 1686781 ttcatgtatc aggccacggc tcacaagaag agttaaagct gatgatcaac ctgcttaaac 1686841 caaaatattt gattcctgta aacggcgaat acagaatgca aaaagctcat tcaaaaatcg 1686901 ctgaagaaac cggcatgaag cgcagtgaca tcttcttaat tgaaaaaggc gacgtcgttg 1686961 aattccgcgg ccaaaacgta aaaattgggg ataaagttcc ttacggcaat attttaattg 1687021 atggtttagg tgtcggtgat atcggcaata tcgtattgag agaccgccgc ttgctttcac 1687081 aggacggaat tttaatcgtt gtcattacac ttgataaaca aaagaaacat cttgtatcag 1687141 gaccagaaat tatcactcgc ggctttgttt atgtaagaga gtctgaaggt cttatcgtac 1687201 aggctactga gcttgtacgg tccatcgtga cagaagcgac tgaaacatca aatgtcgaat 1687261 ggtcaacgct gaagcaggca atgcgggatg ctttgaacca attcctttat gaaaaaacga 1687321 aacgtaaacc gatgatcatc ccaattatta tggaagtata atgactgact aaagaccgga 1687381 gctgctccgg tctttatttt ttgtccttca agccgggatt gaatgaagta tctttgttca 1687441 taatacaaag agaaactcgg aaaggatgaa agcgagatgg atcatcgtat ggaaaacaca 1687501 gaagaagagc gtcctgaaaa aaatgatgcg aaggacagca ttatgaataa aatacagcag 1687561 cttggtgaaa cgacgcttcc gcagctgccc caagatacaa atattcattg tctgaccatt 1687621 atcggacaaa ttgaaggcca tgttcagctt cctccgcaaa acaaaacaac aaaatatgaa 1687681 catgtcatcc cgcagattgt ggcaattgaa caaaatccca aaattgaagg cttgctgatc 1687741 atattaaata ctgtcggagg agatgttgaa gctggtcttg ccatagcgga aatgcttgca 1687801 tctttatcga aaccgaccgt ttctatcgtg cttggcgggg ggcattcaat cggcgttccg 1687861 attgctgtat cctgtgatta cagctatatc gccgaaacag caacgatgac gattcatcca 1687921 gttaggctca ccgggctggt catcggggtg ccgcaaacgt ttgaatacct ggataagatg 1687981 caagaaagag ttgttaaatt tgtgacaagc cattccaata taaccgaaga gaagtttaaa 1688041 gagctaatgt tttcaaaagg aaacttaaca cgcgatatcg gaacaaatgt agtcggtaag 1688101 gatgcagtta aatacggatt gatcgatcac gcaggcggtg tcggacaggc aatcaataaa 1688161 ctgaatgagc tcatcgatga agcaaggaaa gaagaaggac ggatgattca atgattcttt 1688221 ataccgtgat gcctcaggaa attgtgtttg cagaacagaa ccaagagaca agcgcacatg 1688281 agcaaattga atataaaggt gtaccgcttc tagtcgaaat gaaagggaat gaagcggaag 1688341 tcattcaaat catgagcacc aatccaatgc attttctgca tccggacatt tcaccgggac 1688401 aaaagctgaa attaaacgta taagaatcca accctttttt aagggcaaaa tatgctataa 1688461 taggggaatc ctacagaaaa aacgcagcct gtaaacggct gctttcttca ttatgtatga 1688521 acttacattt tttaacgcag taaggtgatg agtgtggcaa agaaaaaacg aaaatcaaga 1688581 aaaaaacagg cgaaacagct caatataaaa tacgagctca acggattgct gtgtatagcc 1688641 atttcaatta tcgcaatctt gcagctgggg gtagtcgggc aaacgtttat ctatttgttc 1688701 cgcttttttg ctggagagtg gtttatttta tgcttgttag gtttattggt gttaggagtc 1688761 tcactgtttt ggaagaaaaa aaccccaagc cttttaacga gacgaaaggc cgggttgtac 1688821 tgtattatcg caagcatatt gctgctttct cacgtgcagc tatttaaaaa tttgacgcac 1688881 aaagggtcta ttgagtctgc aagcgtggtg cgcaatacgt gggaattgtt tttaatggac 1688941 atgaatggca gctctgcttc acctgattta ggcggaggga tgatcggtgc gctgctgttt 1689001 gcggcttcac actttttgtt tgcgtcgact ggttctcaga tcatggcaat tgtcatgatt 1689061 ttgatcggaa tgattttagt aacaggacgc tcgctgcaag aaacgctaaa aaagtggatg 1689121 agcccgattg gacgttttat aaaagaacaa tggttagcat ttattgatga catgaaatcc 1689181 ttcaaatcaa atatgcagtc atcgaaaaaa acgaaagcgc cgagcaaaaa acaaaaaccg 1689241 gcccgcaaaa aacagcaaat ggaaccggag cctcctgatg aagaggggga ttatgaaaca 1689301 gtatcgcctc ttattcattc agagccgatt atctcaagct tttctgatcg taatgaagag 1689361 gaagagtctc cagttataga aaagcgcgcc gaacctgtgt cgaagccgct tcaggacatc 1689421 caaccggaga caggtgatca ggaaactgtt tctgctcctc ctatgacctt tacagagctc 1689481 gaaaataagg attacgagat gccgtcactg gatttgctgg cagatccgaa gcataccggc 1689541 cagcaggctg ataaaaagaa tatttatgaa aatgcgagaa agcttgaacg cacattccaa 1689601 agctttggcg taaaggcgaa agtcacacag gttcatctcg gaccggccgt aacaaaatat 1689661 gaagtatatc ctgatgtcgg agtgaaggtt agcaaaattg tcaatttaag cgatgattta 1689721 gcgcttgcgc ttgctgcgaa ggatatcagg atcgaagcgc ctataccagg caaatcagca 1689781 atcggaattg aagttccaaa cgcagaagtg gcaatggttt cgctgaaaga agtgctggag 1689841 tctaaattga atgacagacc ggatgcgaag ctgttaattg gactcggccg caatatttca 1689901 ggtgaagctg tattggctga gttaaacaag atgccccacc ttttggtcgc aggcgcaacc 1689961 ggtagcggga aaagtgtctg tgtcaacggc attattacaa gtattttaat gcgggcgaaa 1690021 ccgcatgaag tgaaaatgat gatgatcgat cctaaaatgg tagagctaaa tgtctacaac 1690081 gggattccgc atttgcttgc tcctgttgta accgatccga aaaaagcgtc gcaggctttg 1690141 aaaaaggttg tcaatgaaat ggagcggcgg tacgaattat tttctcatac gggtacaaga 1690201 aatattgaag gatacaatga ttatataaaa cgcgccaaca atgaagaagg agcgaaacag 1690261 ccagagctgc cttatattgt tgtcattgtg gacgagctag ccgatctcat gatggtcgct 1690321 tcatctgatg tggaagattc gattacgaga ttgtcccaaa tggcgcgggc tgccggcatc 1690381 catcttatta ttgcgacaca gcggccatcg gtggatgtta tcacaggggt gatcaaagcg 1690441 aacattccgt cacgaatcgc gttcagcgta tcttcacaga cggattcaag gaccattctt 1690501 gacatgggtg gcgctgagaa gcttcttggc cgcggcgata tgctgttttt acctgtaggg 1690561 gctaacaaac ctgtccgtgt gcagggagca tttttgtcgg atgacgaagt ggagaaggtc 1690621 gtcgaccatg tgattactca gcagaaagcg caatatcaag aagaaatgat tcctgaggag 1690681 acgacggaaa ctcattccga ggttactgat gaactttatg atgaagctgt tgaattaatc 1690741 gtcggcatgc agacggcatc tgtttcaatg ctgcaaagaa gattcagaat tggctatacg 1690801 agagcggcgc gcctgattga cgcaatggag gaacgcggtg ttgtcggacc gtatgaaggc 1690861 agcaaaccta gggaagtatt attatcaaaa gagaaatatg atgagctctc ttcttaatga 1690921 agggagttcc gctttctata gttgtcaata atgatattat gtaaactgat cacctttcta 1690981 tttatttttt cgacaaaaca tgatatagtt gtcccaattg ttcaataatt tttatcgaaa 1691041 gtggtttacg gaggggaaac atgtctacaa aagctgataa tcggcacttg tatttgaaag 1691101 taattgaacg aattaaagag gatataaaaa atgggatcta cactgagaag gaaaagctgc 1691161 cttctgaatt tgagctttcc aaaaagcttg gtgtcagcag agcgacgcta agagaagcct 1691221 tgcggatact ggaagaagag catgtgatta tcagaaggca tggtgtaggc acttttgtcc 1691281 attctaagcc gttatttctt tcgggtattg aacagctgaa cagtgtaacc aagatgatag 1691341 aacaggcgaa tatgacccct ggcacgattt ttctatcatc acaagtgctt atgccgtctg 1691401 aagatgatac gaagagattt cacttggcag aagggcaaga acttttttac cttgaacgag 1691461 tcaggacagc tgacggacag ccgattgtgt attgtataga caaaattccg atgaatattt 1691521 tgccgaattc tttttctcat cagcaagaat ctatgtttga cctgctagag aaaaattcag 1691581 gctccgtaat cagctatgca gtaactgata tagaaccgat cggctatcac gataccattt 1691641 ctccagtgct tgaatgcgat ccggaaacag ctcttttgct gttaaaacaa acccattacg 1691701 atcagcacga taaaccggtg ctttattctt taaattattt tagagcggat aaattcagat 1691761 ttcatgtttt gcgtaaacga ttctaaaaac ggacgcctgt atgtgtctgt ttttttattt 1691821 gcactgattc atgtttcttt gtacatactt tcattccggt taacgcaata tataagggat 1691881 gacaagaaag tgaatgggtg aaaatgttga gagagaaaaa tggaatgaaa aatattattg 1691941 cattgtcttc tgtcccgctt gtgatgacac tcgggaactc catgctgatt cctgttcttc 1692001 cgatgatgga gaaaaagctg tctgtgactt catttcaagt atctttaatc attactgtat 1692061 attcagtagt agcaattatt tgcattccga ttgccggata tttgtcggat cgtttcggga 1692121 gaaaaaaaat attgcttcca tgcctcctca ttgcaggatt ggggggagcc gtagctgctt 1692181 ttgcctcgac ctatatgaaa aatccttatg ctatgatctt ggcggggcgg gttcttcaag 1692241 gcattggttc tgcaggtgcc gctccgattg tcatgccgtt tatcggcgac ctgtttaaag 1692301 gagacgatga aaaggtcagc gcgggtcttg gcgatattga aaccgccaac acgtcaggga 1692361 aggtactgag tcccatactt ggagccttac tggcttcttg gtattggttt gtaccgtttt 1692421 ggtttattcc gtttttctgt ttgatcagct ttttgctcgt attgtttttg gtggccaagc 1692481 ctgaagaaga tgaagatgcg cctgctgttt ctgagtttat taagagtgtg aagaaaattt 1692541 ttaaacagga tggtcgctgg ctttatacgg tcttcattat cgggtgtgtc attatgtttt 1692601 tgttatttgg cgtattattt tatttatcag atacgctgga gaacaagtat gctattgacg 1692661 gagtagctaa aggcggatta ctggcaatcc cacttttgtt tttgtcaacc agttctttta 1692721 tagctggcaa aaagatcggt aaagataaag gccgaatgaa attttgcgtt gttacaggaa 1692781 tgattctgtt aaccctttcg tttattgcct tgtggtggaa ccacagtttt tattttttat 1692841 ttgtcttttt aagctttggc gggattggga ttggaatggc tcttcctgct ttagatgcat 1692901 tgataaccga agggattgaa agtgaacaat gcggaaccat ttcctccttt tacaatagca 1692961 tgcgctttat aggagtagct ctcggtccac ctgtttttgc tgcattaatg tctaatgcaa 1693021 actggattat tttcatactc tcggcgtttt gcagcatcgt ttctttattt ttagtgctct 1693081 ttactgtaga tgctaaaaaa agtgaagaag aaaaaaactt agggacggtc tagccagccg 1693141 tctttttttg cgctttcttg cacagtttac aactgtacct atacagcatg cggaggttat 1693201 tgtttcctta taaatcctac agttgctata attacatgaa agagtgtttc tgcggatgct 1693261 gaaaattggt cataatacat actaattaag aaatgaacga aggaggttcc atatgtcata 1693321 tgttaatgaa ctcaaatcaa agcacggcgg tttaaccgca cacattgtaa aaacagaaaa 1693381 attcaaaacc gtctcgctta tttttaagat gcttgcgccg ctgacaaagg atcaagtcac 1693441 caaaagagcg cttctcccgc atgtgcttct tcgcggaacg aaaagccatc cgaaaaccgc 1693501 aggattgcgt tcatacttgg atgagctgta cggcacgtca gtatcggctg atcttacgaa 1693561 aaaaggagag cggcatgtca ttacgttcag gcttgaaatc ccgaatgaaa aatatttaaa 1693621 agaccaaacg ccgcttctcg agaaagggct ccagcttctc gcagaactcg tcttttcacc 1693681 tgctttggag ggagacgctt ttcagtcaca atatgtggct caagaaaaac ggacgcttaa 1693741 gcaaagaatc caagccgtct atgatgataa aatgcgttat tcgaatttaa ggctgataca 1693801 ggaaatgtgc aaaaatgatc cttacgcgct tcatgtcaat ggtgaaatcg acgatgtcga 1693861 tgacattacg gcagagcaat tatacgaaac ataccaaagc gctatccaaa aagaccagct 1693921 tgatctatat gttgttggcg acgtggacag taaccaggta caatcggcaa ttgataagta 1693981 tttcaaaaca gaagagcgca ctcttggcat gattgaaaac aatcacgctg atgaaaaagt 1694041 tcagccaaaa gaagtaattg atgaagagga tgtcaagcaa ggaaaactga atatcggcta 1694101 ccgcaccagc atcacttata cagatcagga ttatcctgct ttacaagtgt ttaacggatt 1694161 gttcggcgga ttctctcatt ctaaactttt cattaatgtt cgggaaaaag ccagtcttgc 1694221 ttactacgcg gcttcgcgta tagaaagttt taaaggcttg ttaatggtga tgtcaggcat 1694281 tgaagtgaaa aattttgaac aggcggtttc gattattgct gagcaattcc aggcaatgaa 1694341 aaatggcgat ttcagtgagc aggatatagc acagacaaag gccgttattc gaaatcaagt 1694401 gctggaaacg attgatacag catacggttt atctgagttt ttatatcagc aggccgctgc 1694461 tcaagtcgag attcctatcg aagactttct tgccaatatt gagaatgtca caaaagagga 1694521 tatcattaaa gccggcgaaa agattcagct tgatacgact tatttcttaa aagggacgga 1694581 gggtgcatct tgatcaaacc aatcgaatat gaacagcttc aggagacgct gtatcatgaa 1694641 aaaatgtcca acggccttga tgtttacgtt ttgccgaaaa aaggcttcaa caagacatat 1694701 gcggtcttta caacaaagta cggctcgata gataaccggt ttgtcccttt aggtaaaaac 1694761 gagatggttc acgtgccgga cgggattgct cactttcttg agcacaagct gtttgagaaa 1694821 gcggacggag acgtttttca agatttcagc aaacaggggg cttctgccaa tgcgtttacg 1694881 tcatttacaa gaacggctta ccttttctca agcacatcaa atgttgaacg caatttagag 1694941 acgcttatcg atttcgtaca ggacccatat tttactgaaa aaacggttga aaaggaaaaa 1695001 gggattatcg ggcaggagat taatatgtac gacgataacc ctgattggag gctttacttc 1695061 ggggtcattg aaaacatgta caaagagcat cctgtcagaa ttgacatagc gggaacagtg 1695121 gaaagcattt cacatattac aaaagacctt ctttatgaat gctatgaaac gttttatcac 1695181 ccgagtaaca tgctcctttt cattgtcggc cctgtagatc ctgaagcgat tatttctcag 1695241 gtaagagaaa accaggggaa aaagccgtat actgatcagc cggagatcaa acgagaagaa 1695301 gtgaaagagc aagaagcggt tttccgaaaa gaaaaagaga tcaaaatgaa cgtgcaggga 1695361 ccgaaatgcc ttgttgggct gaaatccaaa aatccgttta aattaggcaa agagctctta 1695421 aagcatgaac tttcaatgaa cttattgctt gaagctcttt ttggcaaaag ctctgcccag 1695481 tatgaatcac tttatgaaaa aggatatatt gacgaaacgt tcagctttga ttttactgct 1695541 gaatatgggt tcggttttgc ggcgatcggc ggagatacgc ctgagcctga tcaattggct 1695601 gaagacattt caagcatgct tttgcgcgcc ggtgaactga ttactgctga aaagattgaa 1695661 cttgccagaa agaaaaagat cggcacattc ttaaaagcgc tgaattcccc tgaatacatc 1695721 gccaatcaat ttacccgtta tgcgttcttg gatatgagcc tgtttgatgt tgtaacggta 1695781 ctcgagcaga ttaccctcga ggatgtccag aacgtaatac aagaggaaat cgctgcagac 1695841 agactgactg tctgcaaggt tgttcctaaa tcataaacaa aacatccctc cagtgtgagg 1695901 ggtgtttttc tgcggaaaga aggaaagagg atgaacaaaa cagcactaat caccggagca 1695961 agcggcggca ttggcaaaag catcagcgaa acccttgcag ctagaggata caatctgctg 1696021 ctgcattaca atacaaatca aaacgcggca gcggagcttg ctgaaaaact aagtcagatg 1696081 tttggcgtaa atgcggagat attacaagct gacctgtccg cgcaagatgg agcagataag 1696141 ctgacaagtt caattgttca gccgattgat gcgattgttt taaacagcgg acgaagccat 1696201 tttgggctga ttacggatgt agataacgca acggtccagg aaatggttca gcttcatgtg 1696261 gcgagtccgt atatgctgac gagaaacctt ctgccaggca tgattcggaa taaatcggga 1696321 gcgattgtgg ctgtcagctc gatttgggga gagactggag catcctgtga agtgttgtac 1696381 agcatggcaa aaggagctca gcattcattt gtaaaaggat tggctaagga gctggcgcca 1696441 agcggaatca gagtaaacgc cgtagcgccg ggtgcagttg atacaaatat gatgaatcaa 1696501 tttaccccgg ctgaaaaaga agagatcgct gatgagattc cgatcggccg gctggcccgg 1696561 ccgcaagaaa ttgcggatgc aacagctttt ctcctgtctg aaaaagcgtc atatatcacc 1696621 ggccaaattc tgtcggtgaa tggcggctgg cactgctgat ccgaaaatat tcggtgtata 1696681 gtttcttttg cgaaggacac aataatcttg taacttcaca tgaaatggag gaaacaagca 1696741 tgtcagtatt agaaaactgg gatagctgga aaaacttcct tggcgaccgt ctgaactatg 1696801 cgcaagataa aggtatgagc caggatacga ttacagatct tgcgacagaa atcggcagct 1696861 acttggctaa tgaagtggaa tctaagaacg agcaggaaaa agtgctggca gatctttgga 1696921 gtgtagcatc aaaagatgaa cagcacgcca ttgccaatat gatggttaag cttgttgaaa 1696981 ataacagcac tcactaggaa gagaggggat ttttcctctc ttttttatgt tttcctcatc 1697041 acagcaacat tcttctttct aattagagaa aaatgcttta tgataaagga aggtaaaatt 1697101 ttgccacaat gaagggggta tatcatttgg caaagctcga atggtatttt gaatatgaaa 1697161 ttcaagtgaa ccgccccgga ctgctcgggg atatttcatc tcttcttggg atgctttcta 1697221 tcaacatcgt aacgataaac ggcgtcgatc tttccagaag gggaatgctc ctcaggtgcc 1697281 gccatataga tcaaattaaa cgattagaat caatcttaaa aacgatggaa acaattaaag 1697341 taacgaagct tagagaaccg aggcttcgcg accgtcttgc cgtacgccac ggccgttata 1697401 ttcaacggga tgccgatgac aagaaaacgt tccgctttga acgggacgag cttggcttat 1697461 tagtcgattt tatggccgaa ttgttcaaaa aagaaggcca taaattaatc ggaatcagag 1697521 gtatgccgcg tgtcgggaaa acggaatcga ttgtagcctc tagtgtgtgc gagcaaaagg 1697581 tggctgtttg tgtcatcaac cttgctgaag cagacgataa gaagccagct gattgccgat 1697641 gaatacagca ctgaaaatgt ctttatcgtt gacggaattg tgtcaacacg aagagggtca 1697701 gaacgccatc tccagctggt ccgagaaatc atgcggctgc ctgcaacaaa agtggtggag 1697761 catccggaca tattcgttca aaatacagag tatacactag atgactttga ttatattatt 1697821 gaactgagaa atgaccctga tgaggttatt acatatgaac atgccgagga accccaaatg 1697881 tttgatcaat ccgggttttc aagctttgat ttttaaaatt ggaaggtgtt tgttgtgact 1697941 gaactaggaa tccggctcaa agaagccaga gaggaaaaag caatgtcatt ggatgatctc 1698001 caagcggcaa caaagattca aaaaaggtat ttaaccgcct tggaggaagg aaactatgac 1698061 attattccgg ggaagtttta tgttcgggca ttcatcaagc aatatgcaga agccgttggg 1698121 cttgatgcgg atcagctgtt tgaggagcat aaaaaagata tccctaatac gtatcatgat 1698181 gatgtgtctg aaaagatctc cggcatgaat cttcaaaagg aaatgccaaa gccagcatct 1698241 aaggcgctgg agctgctgcc aacaatactt gttattctcg gcgtgattgt cgtgattgcc 1698301 attgtgtacg cgatcattca atttgccaat cacaaaaaca gtgatgatca caatgcggca 1698361 tcagaaaaag caattacgca aagtgagagc aagtacgaaa tccctaaaga ttcaacgctg 1698421 aaagagaatc aaaataacag ctctgaaaaa gagacagaca ctaaaaaaga aacgaaagaa 1698481 aacgaagata agaaaaaaga aaatgacagt gagaagctgg agattaaagc tgctggcact 1698541 gaaggatcgt taacgactta tgaagtgtcc ggcgctgata aaatcgagct ggaactgaag 1698601 gcatcagaca gctcctggat tagagtgcgc gatgaaaaca gcagctcttt aaaagaagga 1698661 acgctgaaaa aagacgaaac ctataaaaaa gacataactg atcagaaaca agttgatatc 1698721 cgcaccggat atgcacctaa tctgaaaata aaaatcaacg gtaaggttct ttcatatgaa 1698781 cttgatccga aaaaagtgat ggcacaaacc ataaagattg taaataaaaa ggaagaaaag 1698841 tcatcttaat taccagatga cttttcttca cgtccgagta tgaaattgga ggggctttat 1698901 gtttaactta ccaaataaaa tcacactagc tagaatcgca ttaatcccaa tcttcatgat 1698961 tatcatgctg gcgccgtttg actggggcag gctcgaagtt ggagacgaat ccatcccggt 1699021 cgcacatttg gcgggggcca ttctatttat tattgcatct acaacagact gggtggacgg 1699081 gtattatgcc cgaaaattaa atctcgtaac aaacttcggg aaatttcttg atccgcttgc 1699141 ggacaaactg ctcgtatccg cagcgttaat tatccttgtt caatttgatc tcgctccagc 1699201 ttggatggtc attgtgatta tcagcaggga gtttgccgtg acaggtttaa ggcttgtctt 1699261 agccggaaca ggagaagtcg tagctgctaa catgcttggt aaaatcaaaa cctgggcaca 1699321 gattattgcg gtatctgcat tgcttcttca taatcttcca tttgaacttg tgtcattccc 1699381 gtttgcagac ttggcgctgt gggtagccgt cttctttact gtcgtctcag gctgggaata 1699441 tttctctaaa aattgggaag cgttaaaaac atctaactaa gaaagaagga cttcgtcatg 1699501 gaatttccaa aaaaagcaga aataattgca gtcggttcag agttgctgct tggtcaaatc 1699561 gccaatacaa atgctcaatt tatcagcaaa cagctcgctg aaatcggggt caacgtattt 1699621 tatcatacag cggtcggaga taacccggag cggctgaagc aggtcatccg cattgctgaa 1699681 gaacgctctg acttcattat tttttcagga gggcttggac ccacaaaaga tgatctgacg 1699741 aaagaaacga ttgcaaatac gctgggacgt ccgcttgtgt taaatgatga ggcattccaa 1699801 tccattgagg actatttcaa acgaacaaaa cgcacgatgt cacctaataa ccgaaaacag 1699861 gcgcttgtga tcgaaggctc tgacgtgctg gcgaatcact ttggaatggc cccgggaatg 1699921 ctcacagagc atgaatcgcg ctattatatg cttcttcctg gaccgccgag cgaattgcgt 1699981 ccaatgtttg aaaacgaggc aaagcctctt ctgctgaaaa agatgggttc aaatgaaaaa 1700041 attgtgtcaa ctgttcttcg ctttttcggt atcggtgaat ctcagcttga agccgatttg 1700101 gaagatatta ttgatgcaca aaccaatccg acaattgcgc ctttggcggc tgatggagag 1700161 gtgacgctgc gtctgacagc caaacacgcc gatgaaaagg aaacagagcg tctgttaaaa 1700221 gaaacagagg ccgttatctt agagcgtgtc ggtgaatttt tctatggtta cgatgatact 1700281 tctcttgtaa aagagctatc tatagcatgt aaggaaaaag gcataacaat ttctgcggca 1700341 gaaagcttta ccggagggct gttttctgaa tggctgacgg atcatagcgg tgcctcaaaa 1700401 ttatttgccg ggggcgttgt ttgctataca aacgacgtga agcagaatgt gcttggtgtc 1700461 aagaaggaaa cattagatcg ttttggggcg gtcagcaagg agtgcgcatc cgaactggct 1700521 aagggtgttc aaaaactcac tggcagcgat atcggcatta gctttactgg tgtagcagga 1700581 cctgatgctc aagaagggca tgagcctggg catgtgttta tcggcatttc cgcaaatggt 1700641 aaagaagagg ttcacgagtt tcactttgcg ggctccagaa cggggatcag aaaacgcggc 1700701 gctaaatacg gctgccattt aatcttaaag cttttagagc aaaaataata ttttcagcac 1700761 attatcctcc taagaaaaca tgatttctct gatacattat gatattttga taggaatcac 1700821 gccaagaaaa aatccgaata tgcgttcgct tttttcttgg caaatccctt caaacagggt 1700881 atagtatatg tagtggtaac ataaaggagg aaaaaataga atgagtgatc gtcaggcagc 1700941 cttagatatg gctcttaaac aaatagaaaa acagttcggc aaaggttcca ttatgaaact 1701001 gggagaaaag acagatacaa gaatttctac tgtaccaagc ggctccctcg ctcttgatac 1701061 agcactggga attggcggat atcctcgcgg acggattatt gaagtatacg gtcctgaaag 1701121 ctcaggtaaa acaactgtgg cgcttcatgc gattgctgaa gttcagcagc agggcggaca 1701181 agccgcgttt atcgatgcgg agcatgcgtt agatccggta tacgcgcaaa agctcggtgt 1701241 taacatcgaa gagcttttac tgtctcagcc tgacacaggc gagcaggcgc ttgaaattgc 1701301 ggaagcattg gttcgaagcg gggcagttga cattgtcgtt gtcgactctg tagccgctct 1701361 cgttccgaaa gcggaaattg aaggcgacat gggagattcg catgtcggtt tacaagcacg 1701421 cttaatgtct caagcgcttc gtaagctttc aggggccatt aacaaatcga agacaatcgc 1701481 gattttcatt aaccaaattc gtgaaaaagt cggtgttatg ttcgggaacc cggaaacaac 1701541 acctggcggc cgtgcgttga aattctattc ttccgtgcgt cttgaagtgc gccgtgctga 1701601 acagctgaaa caaggcaacg acgtaatggg gaacaaaacg aaaatcaaag tcgtgaaaaa 1701661 caaggtggct ccgccgttcc gtacagccga ggttgacatt atgtacggag aaggcatttc 1701721 aaaagaaggc gaaatcattg atctaggaac tgaacttgat atcgtgcaaa aaagcggttc 1701781 atggtactct tatgaagaag agcgtcttgg ccaaggccgt gaaaatgcaa aacaattcct 1701841 gaaagaaaat aaagatatca tgctgatgat ccaggagcaa attcgcgaac attacggctt 1701901 ggataataac ggagtagtgc agcagcaagc tgaagagaca caagaagaac tcgaatttga 1701961 agaataaaaa taaaataagt ttcaaatgat acaaaaggct gagtgaaaaa ctcagctttt 1702021 ttgtattttg caaaaaaatg ataaaaatat tgcttttttt gacaactttt ttagggcttt 1702081 attcgtctaa caaaacgtgt gcaaaatgga atttattttg ggaggaaaaa atgaatgaca 1702141 agcccaaccc gcagaagaac tgcgaaacgc agacggagaa aactaaataa aagaggaaaa 1702201 ctgttgtttg gtcttttagc agtgatggtt tgcattacga tttggaatgc tcttcatcga 1702261 aatagtgaag aaaacgaacc atctcaagaa actgcagcgg tttcaaatac cgatcagaaa 1702321 aaagaggtca aaaagaaaac tgccaaaaaa tcagaggaac aaatcaaaac agtggatcga 1702381 aaccaaaaaa tcagcaatta tttaaaagag atcggtttca gcggaacagc catgattgtc 1702441 agaaatggag aaatcgtaac aaataaaggt tttggctatg ctgaccgtaa acactacatt 1702501 caaaataatc cattgacatc tttttatgtc ggttcatcac aaaaagcgct gattgcaact 1702561 gctattttgc agcttgagga aaaggggaaa cttcagacaa gtgatccggt aagcacgtat 1702621 ttacctcatt ttcccaacgg acaaacgatt actttgaaga atctgcttac acatacatcg 1702681 gggataaacg gacatattga aggaaacggc gccattactc cggacgattt aataaaagat 1702741 atagaacttc agggaatcaa acgtcagccg ggcgtatggg actacaagga ttccaactat 1702801 tctgttcttg cttatattat tgctgaagta agcggtgagc cctatgaaca gtacataaag 1702861 aatcatattt ttaaacctgc gggaatgacg catgcaggct tttacaaaac atatgaaaaa 1702921 gaaccttatc ctgccgtcgg gtataagatg gagggcagca aaacagttac accgtatata 1702981 cctgatttat cccagctgta tggagcgggt gatatttata tgagcgctat agatatgtac 1703041 aaatttgacc aagcgctgat agacggaaaa ctgtattcgc aaaaaagcta tgaaaagatg 1703101 tttacgccag ggagcagctc cacatacggc atgggatttt atgttgctcc cggaagctat 1703161 tcaaaccatg gtgttatgcc gggcttcaat atcttgaaca gctttagcaa atctgggcaa 1703221 accattgtta ttttgttctc aaacattcaa aataatgcta aattgggcca agtgaacaat 1703281 aaaatatacc agcttctaaa tcaagaatga ttggcgatct tcttttggat gaattgcatt 1703341 cggcacgtga aaagaagact ggcctgcaaa cgttaagatg gcaagcttga caagtatttc 1703401 cgacacattt acaatgaagt tgtaacattt gtttttttaa catgattgtt aaaccattta 1703461 aacttgacaa gggcgatgaa cacactcatt ccctgtgaag gttctgtatg ttgagaaaac 1703521 tagacaatgt acatgccgac actttttaag caacaaccaa gttcatagca agaggaggtg 1703581 aaagtatgac cccaattatg atggttctca tctccatttt gctgattcta ctcggtttag 1703641 ttgttggcta ctttgttcgt aaaaccattg ccgaagcgaa aattgcgggc gcacgcggtg 1703701 cagccgagca aattcttgaa gatgcgaagc gtgatgctga agcactgaaa aaagaagctc 1703761 tgcttgaagc aaaggatgaa atccacaaac ttcgaataga tgctgaacag gaagttcgtg 1703821 aaagacgaaa tgagcttcaa aaacaagaaa accgtttact ccaaaaggag gaaaaccttg 1703881 atcgcaaaca tgagggaatt gataaacggg aagcgatgtt ggagaagaaa gatcattctc 1703941 tgaatgaacg acaacaacat attgaagaga tggaaagcaa agtggatgag atgattcgta 1704001 tgcagcagtc tgagttggaa cgaatttcga gtctgactcg tgacgaagcg aaacaaatca 1704061 ttcttgagcg ggttgaaaac gagctttcac atgacatcgc catcatgaca aaagaaactg 1704121 aaaaccgtgc gaaagaagag gcggataaga aagcgaaaaa cattctttca ctcgccttac 1704181 agcgctgcgc agcggaccac gttgccgaaa caacggtatc agttgtcaat cttccaaatg 1704241 atgagatgaa aggacgtatc atcggacggg aagggcgtaa cattcgtacg cttgaaacgc 1704301 tgacaggaat tgacctgatt attgatgata cgcctgaagc tgtcattctt tccggatttg 1704361 atccgatcag acgtgagaca gccagaattg ctcttgataa actcgttcag gatggccgta 1704421 ttcatccggc acggattgaa gaaatggttg aaaaatctcg ccgcgaggtc gatgactata 1704481 ttcgtgagat gggtgagcaa acgacatttg aggttggcgt tcatggcctc cacccagatc 1704541 tcatcaagat cctcggccgc ttaaagttcc gtacaagcta cggtcaaaat gtgcttaagc 1704601 attccatgga agtcgcattc ttggccggtc taatggcatc ggagcttggt gaagacgcaa 1704661 agcttgctaa acgtgcgggt cttcttcacg acatcgggaa agcaattgac catgaagtag 1704721 aaggaagcca cgttgagatc ggggtagagc ttgcgaccaa atataaagag cacccagtcg 1704781 tgattaacag tattgcatca caccacgggg acgaggagcc gacttccatt attgctgtac 1704841 tggtagctgc agcagatgcg ctttccgctg caagacctgg cgcaagaagt gagacgctcg 1704901 agaattatat tcgaagactt gaaaaacttg aagaaatttc tgagtcctac gaaggtgttg 1704961 aaaaatcatt tgccattcag gctggacgcg aagtgcgaat tatggtgaag ccggattcaa 1705021 ttaatgatct tgaggctcat cgactggcgc gagatatccg caagcgaatt gaggacgagc 1705081 tcgattatcc aggtcatatt aaggtgacag taatcagaga gactcgagcc gtagagtatg 1705141 caaaataaag tgatgcgcta agcatcactt tatttttttg acggcaagga attttcaaga 1705201 agaaaggatt tacaaaatga gaattttatt tatcggagat gttgtcggtt caccgggccg 1705261 tgacatggtc aaagaatatg taccaaagct aaaaacaaaa tataagcctc actttaccat 1705321 tattaatggt gaaaacgccg cacatggaaa aggcctgacg gaaaaaattt atcacagctt 1705381 aatccagtcc ggcgcagatg caatcacaat ggggaaccac acatgggaca aaaaagaaat 1705441 atttgatttt atagatgacg ttccgaactt ggttcgcccg gcaaactttc ctgaaggaac 1705501 accggggaaa gggatcacat atgtgaaagc aaacggcaaa gaactagcag tcattaattt 1705561 gcagggacgt acgtttttgc cgccgcttga tgacccgttt ttaaaagcgg atgaattgat 1705621 cgcagaagct gcgaaaagaa caccgtacat ttttattgac tttcatgccg aagcgacaag 1705681 tgaaaagctc gcacttggct ggtacacgga tggacgggca tcggctgtag taggaactca 1705741 tacacacgtg caaacagcgg ataaccgcat tttgccgaag ggaacggcat atattactga 1705801 tgtgggaatg actggcccgt atgacggtat actggggatg gacagagaga cgattattaa 1705861 gcgattcaaa acgaaccttc cagtccggtt tactgtcgct gaaggaaaaa caacgctcag 1705921 cggagttgtc attgacattg acgatcaaac gaaaaaagcc gtgaaaattg agcgtatttt 1705981 aatcaacgat gatcacatgt tctttgaata gttgaacata tggttatttt ataaaaatat 1706041 taaaaagaaa agcaggaata tagcaactcc ttagtgaata tagtaaaaat ggaaggtagc 1706101 ccgctatttt tgaaaagcat tgtggggatg gctttttgga tagcaacatc taataatgat 1706161 tgttctaatg aacactcact tatccattgt aaaactaagg gggagcagaa atggaaatct 1706221 taaaagtttc agcaaaatcg agtccaaatt cagtggcagg tgcgcttgca ggcgtgttga 1706281 gagagcgagg agccgccgag attcaagcga tcggagcggg tgcattaaac caggctgtaa 1706341 aagctgtggc gattgccagg ggatttgtgg cgccaagcgg cgttgatttg atttgtattc 1706401 cggcttttac agatattcaa atcgatgggg aagaaagaac agcgattaaa ttaatcgtgg 1706461 agcctcgcta aaaacaaata aagcattctc aacctgtttg cgtaatgcaa acaggttgtt 1706521 tttcatttat tgtgatattt tctcccgata gtatttttag cacataaatg agcgaatata 1706581 caaaatcaga aatgagctaa aacgtttcaa aaaaaatttc cgcccatttt tcaagacaga 1706641 tacttttgtc cttctggaaa agacagttct gtttacgctt attccatatc atggtacaat 1706701 ccgaatataa caagaatttt tcaaggagga ttgtacatgc agagtggaaa gatgaaagct 1706761 ctaatgaaaa aggacggggc gttcggtgct gtgctgactg aagttcccat tcctgagatt 1706821 gataaacatg aagtcctcat aaaagtgaaa gccgcttcca tatgcggcac ggatgtccac 1706881 atttataatt gggatcaatg ggcacgtcag agaatcaaaa caccctatgt tttcggccat 1706941 gagttcagcg gcatcgtaga gggcgtggga gagaatgtca gcagtgtaaa agtgggagag 1707001 tatgtgtctg cggaaacaca cattgtctgt ggtgaatgtg tcccttgcct aacaggaaaa 1707061 tctcatgtgt gtaccaatac tgctataatc ggagtggaca cggcaggctg ttttgcggag 1707121 tatgtaaaag ttccagctga taacatttgg agaaatcccg ctgatatgga cccgtcgatt 1707181 gcttccattc aagagccttt aggaaatgca gttcataccg tactcgagag ccagcctgca 1707241 ggaggaacga ctgcagtcat tggatgcgga ccgattggtc ttatggctgt tgcggttgca 1707301 aaagcagcag gagcttctca ggtgatagcg attgataaga atgaatacag gctgaggctt 1707361 gcaaaacaaa tgggagcgac ttgtactgtt tctattgaaa aagaagaccc gctcaaaatt 1707421 gtaagcgctt taacgagtgg agaaggagca gatcttgttt gtgagatgtc gggccatccc 1707481 tcagcgattg cccaaggtct tgcgatggct gcgaatggcg gaagatttca tattctcagc 1707541 ttgccggaac atccggtgac aattgatttg acgaataaag tggtatttaa agggcttacc 1707601 atccaaggaa tcacaggaag aaaaatgttt tcaacatggc gccaggtgtc tcagttgatc 1707661 agttcaaaca tgatcgatct tgcacctgtt attacccatc agtttccatt agaggagttt 1707721 gaaaaaggtt tcgaactgat gagaagcggg cagtgcggaa aagtaatttt aattccataa 1707781 agggggataa acatgacgaa ggaatttgag tttttaaaag cagagcttaa tagtatgaaa 1707841 gaaaaccata catggcaaga cataaaacag cttgaatcta tgcagggccc atctgtcaca 1707901 gtgaatcacc aaaaagtcat tcagctatct tctaataatt acctcggatt cacttcacat 1707961 cctagactca tcaacgccgc acaggaggcc gttcagcagt atggagccgg caccggatca 1708021 gtgagaacga ttgcgggtac atttacaatg catcaagagc ttgagaaaaa gctggcagcc 1708081 tttaaaaaaa cggaggcggc acttgtattc caatcaggct tcacaacaaa ccaaggcgta 1708141 ctttcaagta ttctatcaaa agaggacatt gtcatctcag atgaattgaa ccatgcctct 1708201 attattgacg gaattcgact gacaaaggcg gataaaaagg tgtatcagca cgtcaatatg 1708261 agtgatttag agcgggtgct gagaaagtca atgaattatc ggatgcgtct gattgtgaca 1708321 gacggcgtat tttccatgga tggcaacata gctcctctgc ctgatattgt agagctcgct 1708381 gagaaatatg acgcatttgt gatggtggat gacgcccatg catccggagt acttggcgaa 1708441 aacggcaggg gaacggtgaa tcacttcggt cttgacggca gagtgcatat tcaggtcgga 1708501 acattaagca aggcaatcgg agtgctcggc ggctacgctg caggttcaaa ggtgctgatc 1708561 gattatttgc gccataaagg ccgtccattt ttattcagca catctcatcc gccggcagtc 1708621 actgcagctt gtatggaagc gattgatgtc ttgcttgaag agccggagca tatggagcgc 1708681 ttgtgggaga atactgccta ttttaaagca atgcttgtga aaatgggtct gactctcacg 1708741 aagagtgaaa cgccgattct tcctatttta ataggtgatg aaggtgtggc aaagcaattt 1708801 tcagatcagc tcctttctcg cggtgttttt gcccaaagta tcgttttccc gactgtagca 1708861 aagggaaaag ccagaattcg cacgattata acagcagagc acaccaaaga tgaactggat 1708921 caggcgcttg atgtcatcga aaagacggca aaggagctcc agctattgta acaagaggaa 1708981 gagtttactc ttcctctttt gattccttat tgattattat tctcaatgag tgtacaatga 1709041 taggttgcca gttgtgcaga gcttcaataa cctttatact gaagggtgga agtttggttt 1709101 gaaaggagaa aatatgacat gaatgaaaaa caaaaattag agagcggaca agttcatcca 1709161 tcggacaaaa aatccgagaa ggattacagc aagtactttg aagctgttta cattccgcct 1709221 tctttaaaag acgcgaaaaa acgaggcaag gaagccgtta cttatcataa tgactttaaa 1709281 atttctgaac aatttaaagg attgggagac ggaagaaagt tctatatccg tacgtacggc 1709341 tgccaaatga atgaacacga tacagaggtt atggcaggga tctttatggc gctcggttac 1709401 gaagcgacaa actctgttga cgatgccaat gtcattttgt taaatacatg tgcaatccgt 1709461 gaaaatgctg aaaacaaggt gtttggtgag ctcgggcact taaaagcact gaaaaaaaac 1709521 aatcccgatc tgattttagg cgtgtgcggc tgtatgtccc aagaggaatc agtcgtgaac 1709581 cgtattttga aaaaacatcc gtttgtcgat atgattttcg gaacgcataa cattcatcgc 1709641 ctgccggagc ttttgtcaga agcatacctt tcaaaagaaa tggttgtaga agtttggtct 1709701 aaggaagggg acgttattga aaaccttcca aaagtccgaa atggaaaaat taagggctgg 1709761 gtcaatatca tgtacggctg tgacaaattc tgtacgtatt gcattgtgcc ttacacacgc 1709821 ggaaaagaaa gaagccgccg ccctgaggat atcattcagg aagtgagaag gctcgcaagt 1709881 gaaggctata aggaaattac tctgttaggc caaaacgtaa acgcgtatgg aaaagacttt 1709941 gaagatatga cgtacggact tggtgatttg atggatgaac tgagaaaaat cgatatcccg 1710001 agaatccgtt ttacaacgag tcatccgcgc gactttgacg accgcctcat tgaagtgctg 1710061 gcaaaaggcg gaaatctgct tgatcacatt catcttccgg ttcaatcagg aagctcagaa 1710121 gttctcaagc tgatggcccg caaatatgac agagagcgtt acatggagct ggtgcgaaaa 1710181 attaaagaag caatgccaaa cgcttctttg acaacggaca ttatcgtcgg atttccaaat 1710241 gaaacggacg aacagtttga agaaacgctt tctctatacc gtgaagtgga gtttgacagc 1710301 gcctatacgt tcatttactc tccgcgtgaa ggcactccgg ctgctaagat gaaagataat 1710361 gtaccgatgc gtgtgaaaaa agaacgcctg cagcgtctaa acgcactggt gaatgaaatt 1710421 tctgctaaaa aaatgaagga atacgaaggc aaggttgtcg aagtattagt tgagggtgaa 1710481 agcaaaaata accctgatat tcttgctggc tatactgaaa aaagcaagct tgtcaatttc 1710541 aaagggccga aggaagccat cggcaaaatc gtccgcgtga aaatccagca agcgaaaaca 1710601 tggtcgcttg acggagaaat ggtaggagaa gcaatcgagg tgaaatgaga tgacgctcta 1710661 ctcaaaaaaa gacattgtgc agcaggctcg aaaccttgca aaaatgattt ctgaaacaga 1710721 agaggttgat tttttcaaac gggctgaagc gcaaatcaat gagaatgaca aagtgtccac 1710781 aatcgttaat cagattaaag ccctgcaaaa gcaggctgtc aatctgaagc attatgaaaa 1710841 gcatgaagcg ctcaaacaag tagaagcaaa aattgacgcg ctgcaagaag agcttgaaga 1710901 gattcctgtt atccaggaat tcagagactc gcaaatggaa gtaaatgacc tactgcagct 1710961 cgttgcacac accatttcca accaagtcac aaatgaaatc atcacatcaa ccggaggcga 1711021 cctgctgaaa ggggaaaccg gttcaaaggt gaagcattca aataacagct gttctctcta 1711081 aacacggtgc ctttacaggc ccgtgttttt ttatcatttg tgcggttaaa aatgaactaa 1711141 ataatctatg taccaaatgt tcaattggtt tttctgtgct cagccgcgta taaactttat 1711201 cgcacttata agtaaagttt ctaggcaccc ctgcatacaa tggaacagaa actttgtatt 1711261 tttatatttt atttataaaa atgcacacta gacaaatgcc cagcataaga taacacgaag 1711321 aagaacaagg aggcatgccg gaatgtctga atacagggaa attattacga aggcagtagt 1711381 agcgaaaggc cgaaaattca cccaatgcac caacaccatc tcgcctgaga aaaaaccgag 1711441 cagcattttg ggtggttgga ttattaacca caagtatgac gctgaaaaaa ttggaaaaac 1711501 ggtagaaatt gaagggtatt atgatataaa cgtatggtac tcttacgcgg acaacacaaa 1711561 gacagaggtt gtcacagaac gggtaaaata tgtagatgtc attaaactca gatacagaga 1711621 caataattac ttagatgatg agcatgaagt gattgccaaa gtgcttcagc agccaaactg 1711681 ccttgaagtg accatttcgc cgaatggaaa taaaatcgtt gtgcaggcag aaagagaatt 1711741 tttggcggaa gtggtagggg aaacaaaggt agttgttgag gtcaatcctg actgggaaga 1711801 ggatgacgag gaagattggg aagatgagct tgatgaagag cttgaagaca tcaacccgga 1711861 gtttttagtg ggagatcctg aagaataaaa aagggactag gggagacagt acccccaagt 1711921 ctctttttta tattgatata tcattctttt atcacttttt gtttatgtta taatgaaggt 1711981 tggaaaatag aaacgttgat acatagtgag ggattaaaca atggccggtt atacgcctat 1712041 gatacagcaa tatttaaaaa taaaggcaga gcaccaggat gcctttttat tttttcgcct 1712101 gggtgatttt tatgaaatgt tttttgagga cgccaaaaaa gcgtcacaag agctggaaat 1712161 tacgttaacg agcagagacg gcggtgcggc tgaaaaaata ccgatgtgcg gtgtgccgta 1712221 tcattctgct tccgcgtata tcgaacagct tattaaaaaa ggatacaaag tggcgatctg 1712281 tgaacagacg gaagatccga aagccgcaaa gggcgttgtg aaaagagaag tagttcagct 1712341 gattacgccc ggaactgtaa tggacggcaa aggcatccat gagtcggaaa ataattttat 1712401 cgcatctgtt tcagcctgct cgaacggata cggacttgct ctgtctgatt taacaacggg 1712461 agaaaatttg gctgttttga ttgaacggct tgaagacgtc atatcagaaa tttattcagt 1712521 cggcgcacgg gaaatcgtgg tttcaggaag cttggatgcc gatacagtgg cacagctgag 1712581 agagcggtgc ggtgcaacga tttcaattga agacggagaa acagacgaac acgtaacgat 1712641 cattgagcac ttaaataatg aagatataac aaaaacattt ctgcgcttat atacgtattt 1712701 gaaaagaacc caaaagcgca gccttgatca tcttcagccc gtgcaggtgt atgagcttga 1712761 ggaagcgatg aaaattgact tgtactcaaa gcgtaatctg gagctgaccg aaacgattcg 1712821 ttcgaaaaat aaaaaaggct cccttttgtg gctgctggat gaaacaaaaa cggcaatggg 1712881 aggccggcta cttaaacagt ggattgaccg gccgcttatc agagtcaatc aaatcgaaga 1712941 gcgccaagaa atggtggaaa cattaatgtc ccatttcttt gaacgggaag atctgcgtga 1713001 acgtttaaaa gaagtatatg acttagaacg ccttgccggc cgcgttgcat tcggaaatgt 1713061 caatgcccgg gatttgattc agctgaagga atcgttaaag caagtgcctg gcatcaaaca 1713121 gctggttgct tcactggctc atgacaaggc caaggaacgt gcaaagcgca ttgacccttg 1713181 cggggatgta cttgaactgc tggaagaagc gctgtacgaa aaccctcctt tatcggtaaa 1713241 agaagggaac ctgattaaag atggttataa tcaaaagctt gatgaatatc gtgatgcaag 1713301 cagaaacgga aaagactgga ttgcccgcct ggaacagcag gagcgggaat acacaggcat 1713361 tcgctcttta aaggtcggct ttaataaagt tttcggttat tacattgaag tgacaaaagc 1713421 aaacttgcat ttgcttgagg aagggcgtta tgagcggaag cagacgttaa ccaatgcaga 1713481 gcgctacatt acacctgaat taaaagaaaa agaagcgctc attttagagg cggaaaataa 1713541 catctgtgag ctggagtacg agctgtttac cgagctgcgc gagaaagtga agcagtatat 1713601 tccgcggctg cagcagcttg caaaacagat gagcgagctg gacgcactgc aatgctttgc 1713661 gacaatcagt gaaaatcgcc actacacgaa accagagttc tctaaagatg aagtcgaagt 1713721 gattgaaggc agacacccgg ttgttgaaaa agtcatggac agccaggaat atgtcccgaa 1713781 caactgtatg atgggcgata acagacaaat gcttctcatt acaggtccaa acatgtcagg 1713841 gaaaagcacg tatatgagac aaatcgcgct catttccatt atggcgcaaa tcggctgctt 1713901 tgtacccgcg aaaaaagcgg tgctcccgat tttcgatcaa atttttacgc gaatcggcgc 1713961 tgcagatgat ttgatttccg gacaaagtac atttatggta gaaatgcttg aagcgaaaaa 1714021 tgcgattgtc aatgcgacga aaaacagcct cattctgttt gatgaaatcg ggcggggaac 1714081 gtccacttat gacggcatgg cgctggcaca ggcgattatt gaatatgttc acgatcatat 1714141 cggcgccaag acgctgttca gcacacacta tcacgagctg accgttcttg aggacaagct 1714201 gccccagctg aaaaacgttc atgttcgcgc tgaagaatat aacggaacgg ttgtctttct 1714261 tcatcaaatt aaagaaggtg cggctgataa aagctatggt atccatgtag ctcagcttgc 1714321 cgaactgccg ggagatctga ttgcgcgcgc tcaagatatt ttaaaagagc ttgagcattc 1714381 aggaaacaaa ccggaagtgc cggtgcagaa acctcaggtg aaagaagagc cggcacagct 1714441 gtcctttttt gacgaagcgg aaaagccggc tgaaacacca aagctttcaa aaaaagaaaa 1714501 gcaagtgatc gatgctttca aatcacttaa tatactggat atgacaccgc ttgaagcgat 1714561 gaatgaaatg tacaagctgc aaaagaaatt acattaaaac ggggtgatga atgtggcaaa 1714621 agtcatccaa ctgtcagatg agctttcaaa taaaatagcg gcgggcgagg ttgtggaacg 1714681 gcccgcctca gtcgtcaaag aattggtgga aaatgcgatc gacgctgaca gcacagtcat 1714741 tgaaatcgat attgaggaag caggccttgc atccattcgg gtcttggata acggcgaagg 1714801 aatggagaat gaagattgca agcgagcttt ccggcgccac gcaacgagta aaataaaaga 1714861 tgaaaatgat ttattcaggg tgagaacgct cggtttcagg ggagaagccc tgccgagtat 1714921 cgcgtcagtc tctcatctgg agattacaac aagcactggt gaaggagctg ggacgaagct 1714981 cgtcctccaa ggaggaaaca tcatttccga atcgcgttcc tcaagcagga agggaactga 1715041 aattgtcgtt tccaacctgt tttttaacac accggcccgt ttgaaatata tgaaaaccgt 1715101 tcatacagag cttggaaaca ttacagatgt ggttaaccgt attgctctgg cgcatccaga 1715161 ggtatcgatc cgcctgcgcc atcatgggaa aaacctgctt caaacgaacg gaaacggaga 1715221 tgtgcgccat gtactggcag cgatttacgg cacggctgtc gccaaaaaaa tgcttccgct 1715281 gcatgtgagc tccttggatt ttgaagtaaa gggatatatc gccctcccag agattacacg 1715341 ggcgtcgaga aactatatgt cgtctgtggt caatggccgt tacattaaaa atttcccgct 1715401 cgtcaaagcg gttcatgaag gctatcatac gcttctgccg atcggacgcc atccgattac 1715461 ttttatagaa attacgatgg acccgatttt agtcgatgtc aacgtgcatc catcgaagct 1715521 tgaggtccgg ctcagcaagg aaacagagct tcatgactta atacgtgacg gaattaaaga 1715581 tgtgtttaaa cagcagcagc tgattcctag tgcccaggtc ccgaaaaaat cagcacctgc 1715641 catcaaaaat gagcagcagt ttataacctt tgatgaaaag cctccggaaa aaaaagttcc 1715701 ggaaaaatcg actgcgccat cttattcacc gatgaagctc agctcagtcg taaaagagcc 1715761 ggttgatgcg gaggaaaaat tgccccctct ccaatttgat gctcctccta tcgttgatca 1715821 ggaacaaacc cttgaggtgt ccgatgtttc agcagaacag cctgaaacat ttgagcagga 1715881 atgccatgag gaacagccgc agccagcgtc tgatcgggtt ccaattatgt acccgattgg 1715941 ccagatgcac gggacttata tattggcaca aaacgaaaac ggcctatata ttatcgacca 1716001 gcacgccgcc caagaacgta ttaaatatga gtacttccgt gaaaaggtgg gggaggttga 1716061 gcctgaggtg caggagatga ttgtaccgct gacgttccac tactccacaa atgaggcttt 1716121 gattattgaa cagcacaaac aagagctcga aagcgtcggt gtctttttag agtcattcgg 1716181 ctctaacagt tacatcgtcc gctgccaccc agcctggttt ccaaagggag aagaagcaga 1716241 gcttatagaa gaaatcattc agcaggtgct cgactccaaa aatatagata ttaaaaaact 1716301 tcgcgaggaa gcggcgatta tgatgagctg caaaggctcc atcaaagcaa atcgccacct 1716361 cagaaacgac gaaatcaaag cgcttctgga cgacctccga agcacatcag acccatttac 1716421 atgcccgcac ggccgcccga tcatcattca ccactcgaca tatgagatgg aaaagatgtt 1716481 caaacgcgtg atgtagcggg ggtggtaggc attgatccat tctctgaatg gatcaatgct 1716541 ttttttgtac tccttcgagt gtcagattat aagaaacggt tgtaaacgtg tgagcagtgt 1716601 taacgcatta tacttcatgg ttcctccgta taacaaaatt tccatttaca ggcaattggg 1716661 attaatgtat attttgggtg agggggtgga aacatatggc atgtggtccg aagatcatta 1716721 tctttttgga tgaacttgat gatccaaatg tgagaatcat tttagaatgc agaatttaaa 1716781 ttacaacatt gtgttttgct ccctgttcgt gtgaacaggg agattttttc gtttatataa 1716841 ctggtgatgt ccaaatatag ggtgttatga attttccata tctgccatcg gctttaagct 1716901 gcttctctat taggctggtt atcaaaagca agttcaatga tagccatgaa agctgatatc 1716961 acaacaagca agacatctgg aatataaata gactgcataa agtaatctgc aaaacagatc 1717021 gttataagat tgctgataaa atacagtata aaagcaaaaa gtgcagtctt tttcaatgaa 1717081 agtgattttg ccaaaatgat agagataatc tttgtgagtg ggtctatgat taaacctaca 1717141 gcaaagcagg ctaaaataaa taaagctaat gtttgattgg aagcgtatgt gatgccaagt 1717201 atggagaata agcctttcat cccgaagaaa aagccgccga agatgactgc aagcgcgatg 1717261 gccgcgataa aagtaataga tacaattccg attaattttg atctcaggtt aaaatcttta 1717321 gagtgctcgt tctgttcttt ttggttcatg tatgacactc ccttcacctg cttactcata 1717381 caaacagcac ccttgaatca gcccaaaata tctataagtc tgttttctga cgaaaatagt 1717441 atagcatatt ttaacaaaac caaaaaaggc cctttccact ggggaagggc ctttttcatc 1717501 atgttaactc ctgagattcg ccgaagcttt ctcttttttt ggccaaataa aatagctggc 1717561 tgtaatgaga aagtcaatgc ctataatgac agtccacagt ttaagaatgc cgctcaacgc 1717621 ctcggttcgg gaagagtcat tgataaaata gatcatccct gccaatagtc ccgcaccaat 1717681 taagtaggcc agcacatgtc ttagccagcc tttcgcaccg tgcttggcat ggtccattcc 1717741 aaaacgtttc agcggttttg ttcctttttt tgtcacataa tattgaaact tttcatctgc 1717801 ccattgaatc atttgtttcc cataagcgat cgatataccg atgtaaacag ctgcaatccc 1717861 atgggctgcg gtcgctgagg ctccgcggta aaggtccaca ccagttgccg ctaacaagat 1717921 caaatcgata actggagtta aggcaaggaa tagcagtcct aatgtatgtc gtttgaatac 1717981 gtagcgtaca gcaagcccca aaacaatgac aacccaaaac gcaatttcac agaaaacaat 1718041 catccatgcg ataccgttca atccattccc ctcttttcaa tacagttgta ttatttaaat 1718101 aatatgttac catctttgtt tttgtaacac aactgtatta taaaaattgc cctctcattt 1718161 ttttcttgtt acaataaagc tatgccaaaa caaattgacc atgagaaaag aagaaaacaa 1718221 attgcagaag caacgtggcg cgtcatttta gaacgaggga tggagggagc atcagccaga 1718281 aatattgcaa aggaagctgg attgtcatta gaagcttgat cggcaatagt tacccttatt 1718341 atcaagataa gaaagaaaag gatttttcgc tacgctcaaa tcctttaaaa aaacacaaaa 1718401 gaccacattt tttaatgtgg tcttttattc ttcaactaaa gcacccatta gttcaacaaa 1718461 cgaaaattgg ataaagtggg atatttttaa aatatatatt tatgttacag taatattgac 1718521 ttttaaaaaa ggattgattc taatgaagaa agcagacaag taagcctcct aaattcactt 1718581 tagataaaaa tttaggaggc atatcaaatg aactttaata aaattgattt agacaattgg 1718641 aagagaaaag agatatttaa tcattatttg aaccaacaaa cgacttttag tataaccaca 1718701 gaaattgata ttagtgtttt ataccgaaac ataaaacaag aaggatataa attttaccct 1718761 gcatttattt tcttagtgac aagggtgata aactcaaata cagcttttag aactggttac 1718821 aatagcgacg gagagttagg ttattgggat aagttagagc cactttatac aatttttgat 1718881 ggtgtatcta aaacattctc tggtatttgg actcctgtaa agaatgactt caaagagttt 1718941 tatgatttat acctttctga tgtagagaaa tataatggtt cggggaaatt gtttcccaaa 1719001 acacctatac ctgaaaatgc tttttctctt tctattattc catggacttc atttactggg 1719061 tttaacttaa atatcaataa taatagtaat taccttctac ccattattac agcaggaaaa 1719121 ttcattaata aaggtaattc aatatattta ccgctatctt tacaggtaca tcattctgtt 1719181 tgtgatggtt atcatgcagg attgtttatg aactctattc aggaattgtc agataggcct 1719241 aatgactggc ttttataata tgagataatg ccgactgtac tttttacagt cggttttcta 1719301 atgtcactaa cctgccccgt tagttgaaga aggtttttat attacagctc cagatcatcg 1719361 aattcctgtc tgagttgatt gacttggcaa aagaacgagg gctaaacaaa ccagataaac 1719421 aaatacgtgc gcaggctcag caaatgatga aaacacagcg cgcctatgat ttggagtcgt 1719481 acactgttaa gcctctccct gatcctgaga cggtaaaatg ttattatttc cgcaacaaaa 1719541 gcaggtcttt ctttggtgat ttagacactt atttcacttt atcaaatgaa aaagaaccgt 1719601 ttgatcaagc tgcctattgg gaggaatggg agcggcaaat tcctcatttc cacctggtgg 1719661 atgtcgattc aagcaaccac ttcatgatat taaccgaacc gaaagcgtca acagccctgt 1719721 tagaattttg cgaaaagctc tattcaaaca ggggagtagt gaatgcgaat ttccttaagg 1719781 ctttccggaa gaaacatgaa gcgagggaag aaaaagaaac agatgaattg gtgaagcgct 1719841 gagaaaacac aaacgccccc tcttttaaaa gggggcgttt tgaatgttat tttgaaagtg 1719901 aaacagggag actttctaat cctcttaaaa agacattttt tctccattga atgtcatcag 1719961 gtgcaaccgc aagttcaata tcaggaaatc tcttcaaaag tgctttaaat gcaatgtggc 1720021 cttccagcct ggcaagaggc gctcctaagc agaaatgaat gccaaaacca aaagaaatat 1720081 gtctattagg cgaccgattt atatttaata tttcggggtt ctcaaaaaaa ttcgggtcgc 1720141 gattggcaga tccgatgcct ataaaaatca tgtctcctct tttgatcgaa tgccccttat 1720201 atgtaaagtc ttcgatggcc caccgatttg ccatcataac gacaggtgag gtgtatcgca 1720261 gcaattcttc aaccgctgta gcgatcattt caggctgctg cttgagcttc tcacattcct 1720321 tcttgtgctg cagcaatgcg agggtgcctg agccgagtaa gttaacagtt gtttcaaggc 1720381 cggctacaac gagcaagaac agcatcgaat agagctcttt ttcgcttaac ttgctgccgt 1720441 tttcctcagc atgcacaagt ttgctgatta aatcgtcttt tggctttatt cttctgtcat 1720501 ggatcagctt agcgatataa tctttaaatt cacgaagggc ctgatttgtc agctctctat 1720561 taccttcaga ggtatcaacc atcgcattgg tccagatttg aaactgtgac cgatcttctt 1720621 ttgggattcc catcaattca gatataacaa taaaaggcaa aggggaagcg aaggatttca 1720681 tgatatccgc tttattttct ttttccattt catctaaaag ctgttcagca atttgttcaa 1720741 tgctgccgcg cagattttca atggttcggg gagtaaatgc ttgatgaaca agtgatctca 1720801 ggcgggtatg gtcaggtgtg tcttttgcca gcatatgatc ggatacaaaa tcgatatctt 1720861 cactaacgtt gagcattttg atttgttctt ggttcatcac attttttacg tctcttgtaa 1720921 ttcgattgtc ttttaaaaag gccatacaat catcgtatcg ggtaattaac caggccggat 1720981 atgtggctcc gaaccgtttt aattcaaatc ggtgaatggg ctcttcctct ctaaatcgtc 1721041 ctaaaactga aaaaggattg tgatgaaact ctttaccatg cggatgaaac atcaattttt 1721101 ccatttgcat tctcctcgcc taatagggta aatagatgaa tcaaattgct gaattagttt 1721161 acaaaaaaca gaatgatttg aaatgtaatc ctgtctctaa aactatatat ctatcttagg 1721221 cgtcattcaa tagggagaag aacgaaaaaa gtgaaaaaac ggctcgatat aaagcagcgc 1721281 ctttgaacga aagctcaaag gcgctacgct gtattatttt gatgaaagtg gctgtcagct 1721341 gtgctggata tcaattgtat atactgcacg atctgttacg accttcaatc cttcgttttc 1721401 ttggtgaata tgaagctcac ctaataaagg aatctcatag gcattttgcg gaagcggtac 1721461 gtttccgtcc tcagtgaatg ttgttccttc gccttctaaa acaagctctt ctttcgcaac 1721521 ataatcatca ggatgattcg tactgcgtat agccactttt tgaaggtgga gaacaatctg 1721581 atccaagtct gatatctctt catcatgggt caattcacct tttctaatat caagcgtctg 1721641 gccgactttt gattccagcc attgagaaag ctgtgtattc gtgtgtgcca tcaatattcc 1721701 tccttttgat ctacacgata ctattcccaa ttgctgcatc ttttacacgg gaaagagccg 1721761 ccccactctt tatgtatgaa acagttcgct gttgagtgcc ttgatatagc gtacggcaga 1721821 acgctggacc gattcgtcgg cattttcttt gacaacttta gagaaagcat tgtaaagccg 1721881 gttgaattga agcggtttta ctttggctgc tatttcttca actttggagg cgggaagggg 1721941 aatgagattt gggtagctgt acataaagct gacccagttt cgatccgccg caaccgtaat 1722001 gatatctccg gtcaatagac agcctttccc ttcattgccc ttgctccaat gcaaaacagc 1722061 accgccttta aaatgtccgc ccagtcggta aaggtccagt cccggcttca tattgagcgt 1722121 ttcccctgac cagaagtgaa tgtgattgct tggccttgtc acccattctt tatcatcctc 1722181 atggatatag atcggcgcct gaaacgcttc agcccactca acctgagtag agtaataatg 1722241 tggatgagac aaggcgatgg cttgaatacc gcctaattcg ttgatttggt caattgtctt 1722301 ttggtcaaga tatgtcatgc aatcccacag cacattgaag cccttatgct gaataagatg 1722361 ggctgtttgt ccaatcgcaa actctggttc agttttgatg ctgtaaagat gctcttcttc 1722421 ctttttaagg atgttttgaa ggtttccttt ctcacgcatg tcttcaaggg ttgtccaagt 1722481 ttgtccatcg ggatgaatat actgtctttc atcctcgcaa atcagacacg agttgggcgg 1722541 atctacagtc tgtgcatgtt gcacaccgca tgtattgcag atataatatg gcactttctt 1722601 cacttccttc atctattttc cattatttta ccttatgatt atgaatattc aaacgaaaaa 1722661 accggcagtt ctgctgagag agaattgccg gcttttgatg atgtttattg gccgggaacg 1722721 gaattttctg cgttgacagc gcccgctccg tagatattcg gatcttcatc tttccatttg 1722781 tccgtgccgt ttttcaaaag ctcttttact tcatcagggg taagatccgg gttttgctga 1722841 agaattaaag ctgcgattcc tgcgcaaatc ggtgttgcca tcgaggttcc tgacattgta 1722901 aagtactgag accctacacg gcttgacttt tggagcttat caatataaga attcggagag 1722961 cgaagggaaa taatattaac acccggcgct aaaatatcgg gcttttcttt cccgtatact 1723021 gtcgggccgc ggcttgagaa ggaagcgaca gtatcatcat cgctgcttgc agtattgtta 1723081 tcgtcaagcg cacctactgt aatcaccttt tcgctcacgc ccgggcttgc aatggtctgc 1723141 gaatcagggc ctgagtttcc ggcagcgaca cagacgacaa tccctgcgct ccacgcttcc 1723201 tcaaccgctc tgactaacgg atcttcctgt tcatgatcat atctaagggc atcgcccccg 1723261 agcgacatgc tcataatatc aatcggttca tcggggttgt cctcattgta ttgaatacac 1723321 cactcaacac cctctataat atctgctaac gttcctgaac cctgcttgtt taataccttt 1723381 acgccgatga gattggcttc cggtgcaggt ccgcggtatt gaccggaaga ggatgcaccg 1723441 ctgcttgcga catcacctgc acagtgtgtg ccatgaccat tatcatcgta cggctctgtt 1723501 ttttgattga ccatgtccgc gaatccgata attcttcctt ctagatcagg atgcgggtag 1723561 attcctgtat cgacaacagc gacagtaaca ccttttcctg tcagggtttg cccgtttctg 1723621 acgacttcct tcgcatggct tgcttcggtt gccgtgtcta aaagcgcttt gacttcgcgg 1723681 tttaaataca ctttacggat attgctgcat tcagagagaa gggaatgtaa tgctgaagga 1723741 gtaacctcgg cgctgcagca gttgattttg ttgaagcggc tttttagctt gctgcgtttt 1723801 tctttttgca gcacctctcc agccatttga aagccggtct cgtgacagcc ttcctcaaat 1723861 tcgataatga ctgacatttt ttttctgttt tgcaatttgg tttcgaaaaa tttatgcaag 1723921 aagcaaggag tccatttgaa gggcttgtaa agttgcaata cggtttcccg taacggccaa 1723981 tctagcttgt gagcatttgc tctcaccatt tgtaccatag agtacccaaa catgtatttt 1724041 cctcctatta taaggttctc tgtatactct atgaacagat gataggtttg gtaagtttgt 1724101 ttgtcctctg taagagacag acaagagttt gtttttctga atctttcgca ttagatacga 1724161 tagattcaga agctgaggaa atcattgggg attgaaaaag aacgtttgtt cgtattataa 1724221 tgtgatcata tcaaactggg aaggggagag caaccgtatg aatttctact tgcaccgatc 1724281 tttggaaagc caaatgccaa tcagcattat atatgaagaa agacggaacg attagtaaaa 1724341 gaacgattat tgtgagacag aaaagcaaaa cgaaaatcaa agcattttgt ttttcgaaac 1724401 aacagatcag aacattttta ttggactcta tcctctcctg tgattttgtg agaacaaata 1724461 agcaaaatct ctattctgca ggccggtaac agctgtccgt ctcagcaacc gggcagcctg 1724521 ttactaaaac cctccttaaa cctatataca tttatttgcc aagtgaggtt gttcctacct 1724581 tttttgtctt tcctctcaac cttttttcac tcttatttga aatgaaccgc taataaccgt 1724641 gacaatcaat tgattttttg aaaccgggaa ctttttcact gatgatattg tgtatacaat 1724701 ggtaagataa aacctattgg ctaaacctca tataatgaac cgcgccattc ttatgaaagg 1724761 agttaaacat gagaagattt ttactaaatg tcatattagt cttagccatt gtcttgttct 1724821 tgagatatgt tcattactca ttggaaccag aaccatcaaa tcagccagat acatattcaa 1724881 atttcagcag cttggcagag aatgagagcc cagccgatta cgatatttca tataatgaga 1724941 aaaaaggaag caaagtctta attatgtctc cgcatggcgg aagaattgaa ggcggagtaa 1725001 gtgagcttgt gcgttatttc aataatgaat actctacata cctatttgaa gggttgaagt 1725061 cccatgataa ccaaacactg cacattacaa gcaccaactt tgatgagcca ttggcaaaaa 1725121 agaaaatcaa ggagcatcaa tatgtggtgg cttttcacgg atataaagga gagaacaaga 1725181 atacccttgt agggggaaca gaccgaaagc gggcgaaaat gattgtgaga gcccttgagc 1725241 ggagagggtt ttccgctgag ttagcgtcgt ctaaaagcgg tcttgctgga ttgaatgccg 1725301 aaaacattaa taaccaaggg gaaacggggc taagtatcca gctggaaatc agccgtgagc 1725361 agagagaagc attttttgat gatttttatt ataaaaatag aaaatacaca aagaacagtg 1725421 aattttatgc ttatgtcagt gcgatcaaag gtgtcctgga aaaagagtat tcgtaacaag 1725481 cagatcagaa gacaaaataa gagaagatca gtagactgaa ataggataaa aaaggaggca 1725541 aaacaatggc agatcatcat ttttatttaa aagcgaactg gccgggtaac cgtaatgatg 1725601 tcggtacgat cgaaagcgga aacctgatca catcgatttc cattcctaaa gaaatggatg 1725661 gcccgggaga agggaccaac ccagatgaaa tgcttctcgg ggcggcagcg acctgttaca 1725721 ttattacact tgcagcgatg atggagagaa gcgggctgga aaaagaagac ttacagatgg 1725781 agtcagaagg cattgtcaac gttacaaaag gagtctttac atacaaaaag atcattcacc 1725841 gtccctctgt cgtgcttaaa catgatgctt cacaagacga cgtcgcattg gcgcacaaac 1725901 tttgtaaaaa agcggagtcg tcatgcatga tttcgcgtgc aattcaagga aatgtcgagc 1725961 tgcagcttga agcctctgtg aaactgggtg gagaataaag aaaacagacg gtcactcaca 1726021 ggccgtctgt tttttatctt cagcgtgggc tttcgattga tttagcacga ccacgcctgc 1726081 aatgacaagc gtgagaccga atacaccttt taaactgatg gtttcgccaa aaagcaaaaa 1726141 cccgacaatt gctgtaagcg cggtaccaac gcccgaccat gttgcatacg cgcttgataa 1726201 gtcaattgtt tttaaagaaa agcttagaaa cgtaaaagca gaaagaaatc cgactatgac 1726261 tccggcaatg ggccaggctt gtgtaaatcc ttctgaaagc ttcaacatcg tgctcccaaa 1726321 cacttcagat acaatggcga gagccaaata aagcaatcct ctcatcttca tcactccttt 1726381 acggccaatt aagtaacacg acccctgata gtaataaaag aatcccgata agccctttgg 1726441 cattcagatc ttccttgaac cattttactc cgatcactgt cgtcagcacc gtgcctgccc 1726501 cgctccaagt cgcataggag aggctcaggg gaatatggtt taaagtcagg gacagcatat 1726561 aaaaggcgag ggaatagcca ataacgacca aagcacttgg cttccacttt ttgaagccat 1726621 cagatacttt cagcatggct gctcctatcg attccgaaca tatggcaatc gtgaggaata 1726681 tatatcctat caacatcatg aattctcctc actatatttt tagattagaa aaaaaacttc 1726741 agctagaaaa atattagtgt atgcctatgt atgagtcaag agattcattt tcacacactt 1726801 aaaaagaccc ctttttaagg ggtcttttgc gtttaataat aaaaagggaa cggggcatac 1726861 ggataatagg ggtatccgcc atacaaataa ggattaaata aagcgcttcc tataagcccg 1726921 cctgcaaggc cgccgataaa cggtcctcca aaaaatccga atggccggcc aaacccataa 1726981 ccaaatccgg gtcttccaaa cccgtaaccg aacccgaacg gtcttccaaa cccaaatggt 1727041 ctcccgaatc cgaacggcct tccaaatatt cttgtatctt cagggctgaa atgctctaac 1727101 tcgttcatgt tttctttcct cctgtaataa agtgtagatg atgcagtgta ttcaccctgc 1727161 ccggatttga ttgggcgaat cgaggaaaag gaggatgtga acacattggg cctgtatcag 1727221 tctgactggt caaaagcacc gccccacgca catgcttatc atgtcaaaac aacgagagaa 1727281 cagggccatt atcatctcat cgaagggttt actcagccgg caaacggatc aaataccgat 1727341 cagcatacac attactatac agggatcact tcatttgaaa acggccattt tcatcggtat 1727401 tacggaatct caggaccggc gattccctta gcagatggca cacattatca tgaaatcgaa 1727461 gaaacgacgt atctggccta taacgagccg attgagatcc agtacggagg ggttgtgtac 1727521 gatcccggag atgacagaag aaaaacgcat cgtcataccc tgaaaggaaa gacaagggaa 1727581 attgtcggca atgagccgct cggctggtag aaggatgttt accgatgcaa aaaaagggca 1727641 aaatggatag gtggttgtcc atgttgaatg ctataatggg gggagattta taaaagagag 1727701 tgatacatat tgaataatac gaagcagccc gttgtcattt tagtcggacc gacggcagtg 1727761 gggaaaacca atttaagtat tcagctagcc aaatccttaa acgcggaaat tatcagcgga 1727821 gattcgatgc agatttataa agggatggat attggaacag ctaaaattac cgaacaggag 1727881 atggagggag tgccccatca tctgattgac attttagatc cccaagactc tttctctact 1727941 gccgattatc aaagcttagt aagaaataaa atcagcgaga ttgcaaatag aggaaagctt 1728001 ccgatgattg tcggcggtac agggctttat atacaatctg tgctttacga ttatacattt 1728061 acggaagagg caaatgatcc cgtgtttcga gagagcatgc aaatggctgc tgagcgggaa 1728121 ggcgctgact ttcttcatgc caaacttgct gcagcagatc ccgaggcagc agctgcgatt 1728181 catccgaata atacaagaag agtcattcgc gcactggaaa ttttacatac gtccggaaaa 1728241 acgatgtccc agcatttgaa ggaacaaaaa cgagaacttc tgtacaatgc agtgttaatt 1728301 ggcctgacaa tggatagaga cacgctttac gaaagaatta atcagcgggt cgatttgatg 1728361 atgcagtcag gccttcttcc ggaagtgaaa cgcttatacg acaagaacgt gagagactgt 1728421 caatcaatac aggcgatagg ctataaagag ctgtatgcat attttgacgg ttttgtgaca 1728481 ctttccgatg ctgtcgaaca gctaaagcag aactcgaggc ggtatgcgaa acgccagctg 1728541 acgtggtttc gcaacaaaat gcaggtcaca tggttcgata tgacaccgcc tgttgatatg 1728601 gagctgaaaa aaaaggaaat tttcacacat atagcaggaa aactcgaact ttaatcgaaa 1728661 ctgtatgata tagagaatca aggaggacga aacatgaaac cgattaatat tcaggatcag 1728721 tttttgaatc aaatccggaa agaaaatacg tatgtcactg tttttttgct gaacggcttt 1728781 cagttgcggg gccaggtgaa aggctttgat aactttaccg tattgttgga atcggaaggt 1728841 aagcagcagc ttatatataa acatgcgatc tcaacgtttg cgccgcaaaa aaacgtccag 1728901 cttgaactcg aatagatcaa aaaatgccat gtcaagacat gaggaaaggc tgtcgggggt 1728961 tcccggcggc catttttaac atgaatccac ttttgctcca agctttttgt gtaagctgac 1729021 catgccaagg cacggtcttt ttttatgaga acaacatacg gaagtaaaaa tggtatatta 1729081 tgtataaaat gaatttggga gtgatcgatc ttgtttgaaa gtgaagcaga actgagacga 1729141 atcaggattg cacttgtatg gatagctgtc tttttactgt tcggggcgtg cgggaatcaa 1729201 gataccatta ttgaaacaga caacggcaat tcagactatg aaacgcctca gcccacctcg 1729261 tttccacttg aacataacca ttttggcgtt atggaggacg gctatatcaa aatttatgag 1729321 tataatgagt cccgcaatga ggtaaagctg aagaaagaat acgcggatga tgagcttgaa 1729381 taaaattcac aagcattcga atttacaaag cggatgccag ccgctaaact aaatacagac 1729441 acagatcaaa cagagggtga aaacatgaag cataaagtga tcgtgaatca ttgggaagaa 1729501 atttgcgaag atgattcttg ctatgaatac ggaacaagta tcattgtgaa cggaaaagaa 1729561 ttaatcagag aagcgtcaat tatcactgct ttgaaggcgg ttttagaaga gatcggcgcg 1729621 gatgttgaaa tagaagaaac agtagagagc gaaaaatgct gtgatagctt aagaaaaaaa 1729681 aatctagact actaagcagt tttttttcat gttatgatat acatcggcta aaaacgacac 1729741 cccgagtagg acgagagatg attctcgttc tgctctcttt tttgggccct aatgagtctg 1729801 cccgtttgcc tgatttgatc aaaatatgaa tttttcataa aaacgaatct atatattgtg 1729861 tttttgctag agggtagtat actatatata gtgttagtga tgagagattc atattttttg 1729921 ataggtcgtg ataaaacgtg gtacaaatca tatttgattc gaaaacaggg aatgttcagc 1729981 ggtttgtgaa taaaacaggc tttcagcaga tacgcaaggt ggacgaaatg gaccacgtgg 1730041 acactccgtt tgttttggtc acctacacga caaacttcgg ccaggtaccg gcatcaacac 1730101 aatcatttct cgaaaaatac gcccatctct tattgggagt cgctgcgagc ggcaacaaag 1730161 tatggggcga taactttgca aaaagcgccg ataccatttc aagacaatat caggtgccga 1730221 tcttgcacaa atttgaactc agcggcacat ctaaagacgt tgaattgttt actcaggagg 1730281 tagaaagagt tgtcacaaaa tcaagtgcca aaatggatcc agttaaataa cgaaatcatg 1730341 atccaaaaag atgggaaatt ccagtttgat aaggataaag aagctgtaca tagctatttt 1730401 gtagattata tcaatcaaaa cacagtcttc tttcacaatt taaaagagaa gctggattat 1730461 ttggttgaaa accaatacta cgaagaggaa ttcttaagcc tttattcttt tgaagacatt 1730521 aaagaagtgt ttaagacagc ttacgctaag aagtttcgtt ttccttcctt catgagtgcg 1730581 tttaaattct ataatgacta tgctttgaaa acgaatgaca agaaaaaaat cctcgagcgt 1730641 tatgaggacc ggatctcaat tgttgcgctg ttcttcgcta acggcgacac tgagaaagca 1730701 aaagaatatg taaacctgat gatcaatcaa gaatatcagc cgagcacacc gacatttttg 1730761 aatgccggca gaaaacgccg cggtgaactt gtgagctgct tcttgctcga agttaatgat 1730821 tctttaaatg acatttcaag agcaatcgat atctccatgc agctttctaa gcttggtggc 1730881 ggggtttctc ttaacctgtc caagcttcgc gcgaaaggtg aagccattaa agatgttgag 1730941 aatgcgacaa aaggcgttgt aggcgtcatg aagcttcttg ataacgcgtt ccgttacgct 1731001 gaccaaatgg gacaaagaca aggctccggc gcggcgtatt taaacatttt ccaccgcgat 1731061 atcaatgatt ttcttgatac gaaaaagatt tctgcggatg aagatgtgcg tgtcaaaacg 1731121 ctttcgatcg gtgttgtcat tccggataag ttcgttgagc ttgcacgcga ggacaaagcg 1731181 gcttatgtat tctacccgca cacgatttat aaagagtacg gccagcacat ggatgagatg 1731241 gacatgaacg aaatgtacga caagtttgtc gacaaccctc gggtgaaaaa ggaaaaaatc 1731301 aacccgcgga aactgcttga aaaattggcg atgcttcgtt ctgaatcagg ctatccatac 1731361 atcatgttcc aagataacgt caataaagtg catgcgaata accatatttc caaggtcaaa 1731421 ttttctaacc tttgctctga agtgctgcag gcatctcaag tttcttcata cacagactat 1731481 gatgaagaag atgaaatcgg tctggatatt tcctgcaacc tgggttcgct taacattctc 1731541 aatgtcatgg agcataaatc aatcgaaaag acagtcaagc ttgcgacaga ctctttaaca 1731601 cacgtgtctg aaacaacaga catccgtaat gcgcctgctg taagacgggc aaacaaagcg 1731661 atgaaatcaa tcggcctcgg tgctatgaac cttcacggct accttgcgca aaacggcatt 1731721 gcgtatgaaa gtccggaagc gcgtgacttt gcaaacacgt tctttatgat ggtgaatttc 1731781 tactccatcc agcgttctgc ggaaatcgca aaagagaagg gcgaaacgtt tgatcaatat 1731841 gaaggatcaa cctatgcgac aggtgaatac ttcgacaaat acgtttcaac tgatttctca 1731901 ccgaaatacg aaaaaatcgc taatctgttt gaaggtatgc atatcccgac gacagaggac 1731961 tggaaaaagc taaaagcatt tgtcgctgaa cacggtatgt atcacagcta cagattatgc 1732021 attgcgccga caggctctat ctcatacgtt caatcaagca cggcgtctgt tatgccgatt 1732081 atggaacgga ttgaagaacg aacatacggc aactcaaaaa cgtactaccc aatgcctggg 1732141 cttgcatcta ataactggtt cttctataaa gaagcctacg atatggacat gttcaaggtt 1732201 gtggatatga tcgccactat ccagcagcac attgatcagg gaatcagctt tacattgttc 1732261 ttaaaagaca caatgacgac ccgagattta aaccgaatcg atctgtatgc acatcataga 1732321 ggaattaaaa ccatttacta tgcaagaacg aaagatactg ggcaagacag ctgcctttct 1732381 tgtgttgttt gattaaagga gagtttatag tgacaaaaat ttatgacgca gcaaactggt 1732441 caaagcatga agacgatttt acccaaatgt tctataacca aaacgtgaaa cagttctggc 1732501 ttccggaaga gattgcttta aacggcgatc tcctcacatg gaagtacctc ggaaaaaatg 1732561 agcaggacac ttatatgaag gtactggccg gacttacgct tcttgacaca gagcagggga 1732621 atacggggat gccgatcgtg gctgaacacg tagatggcca ccagcggaaa gcggtgctga 1732681 actttatggc gatgatggag aacgctgtcc atgcgaagtc gtactctaat attttcatga 1732741 cccttgcacc gactgaaacg atcaatgaag tatttgaatg ggttaaacaa aataaatatt 1732801 tgcagaaaaa agcgcaaatg attgtcgggc tttacaaagc cattcaaaaa gatgatgaaa 1732861 tttcactgtt caaagccatg gttgcttccg tctatctgga aagcttcctt ttctacagcg 1732921 gtttctatta tccgttatat ttctacggac aaggaaaact gatgcaaagc ggtgagatca 1732981 ttaacctgat ccttcgtgac gaagcgattc acggcgtgta tgtcggtctc cttgctcagg 1733041 aaatttataa taaacagaca gaagagaaaa aagcagagct tcgtgaattt gcgatcgacc 1733101 tcctgaatca gttatatgaa aatgagcttg agtatacaga ggacttgtac gatcaagtcg 1733161 ggctctcaca tgatgtaaag aaattcatcc gctataatgc gaataaagcg ctgatgaacc 1733221 ttggatttga tccatacttc gaagaggaag acattaatcc gatcgtttta aacggattaa 1733281 acacaaaaac aaaatcgcat gacttcttct ctatgaaggg gaatggctat aaaaaagcga 1733341 cagttgagcc gctcaaagat gatgactttt attttgaaga tgaaaaagag cagatataat 1733401 atctgctctt ttcggcttga aggttcaaat gaggaggacg cagtacccat gggaaaaatg 1733461 gacgaaatga ttttagttgc cccgcgcgat gatgtgttta aaaaagaaag cttaaccttc 1733521 cagggcgtgt acagtgaaga tagcagagta gcagaaatca tggctcagat tgaagcggcc 1733581 tatcgtgaaa tgagaagagg ggacgcagaa gaagatccgc gtttcaagca gccgatacct 1733641 tatgtcgtca ttaagcgtga agatgaagtt tttctttacg agcggctggc tggcggcggt 1733701 gaatcacgtc tgcacaacaa gctttctctc ggttttggcg gccatatgaa cgccatcgaa 1733761 ggggcagctt catttgctga agtcttaaag ctgaacacag accgtgagct tgaggaagaa 1733821 ctgcaaataa atgaagaaga taaacaggcg attgtcacac tgggattgat caatgatgat 1733881 gaaaacagtg ttggcaaagt gcatatcggt attctttctg cgcttcaatt aaagcctggc 1733941 gcacaagtgg aagtgaagga gaaagaacaa attgcgggta aatggatgaa agtttctgaa 1734001 ttaaaacagg atgatatcta caaccgtctg gaaacatggt cacagtttgt tgttgatatt 1734061 cttgaataaa aaaacccggt ttctcgcgat gaggagccgg gtttttttat gagacgctcg 1734121 tccccgtctc ggctatgatt ctaggatcac aatagcgtca aagccggcat ttttcgctct 1734181 ggcagcgagg gtgtctgcat tgtctttgga tgaaaatgcg ccaatctgca ctttgtataa 1734241 tccgtccttt aaaaggacaa tcgagtcaaa acctttggct tcggcattac ttgcgagcga 1734301 gtcggcattc gctttgactt taaatgcgcc gatttgaacc ttatataacc ctgagctgga 1734361 agtcttttta aggttaaagg cttgctccag cccgtttgca tgtcctctcg ctaagctttg 1734421 aataaaactg ctcgttttca gcttatttgc atcggaaacg gtatcaatga agccgttctc 1734481 ggtcaagagg gcaggcattg ccgactccct taggacgtgg aagttcgctg tttttttgcc 1734541 gcgatcggca aagtcgacag cttgtatcac ttcagagtga attgtcgatt gataagtcgt 1734601 cgtcggggct cctacatctg gataaatata gctttcaaaa cctgtgcctc ccccggaatt 1734661 aacgtgaatg gacaaaaaga aatctgctcc ccagttattt gcggcatttg tccggtcgtt 1734721 taagctgaca tattggtcgc ttgtccggct cagcagcaga gaaacgcctt catattcatt 1734781 agttaatatc gtacgtaagg ctaaagcgat ttgcagggtt aacgttttct cctgaaggcc 1734841 attacctgtt gcgcctggat cagacccgcc atggccagga tcaataaaaa ttttaaccat 1734901 ttttcatcac ctcattacag gatatgaaaa aacacggctt ctgcttgtac gattatcatt 1734961 caactgaaaa atgaggaaat aaccctttca catccagaaa ttatttctcg ggaaagcgca 1735021 caattcaaca tgaagcgaca acagatacgg tccgacatga aatctgtgca tacgccatat 1735081 gtttgtatgt actatgggtt cggttaacct gcactgattc ctgctggttt taagctttgc 1735141 gttcatatta aatcaagcat ttaaaacgta aattgatgag gaaagctcct ttcattaaag 1735201 acaccgcttt ataaatcgaa aaaaagaaaa acacttcagg tatcttaggg cgggtaatac 1735261 gtttcgtaca aaaatcagcc cgttgtatga aaaagaaata atgagaaaga agctcactat 1735321 aatactctga caaaatgatt aaaaacaaaa tctcatggtt tgtccacccc atgtccgtga 1735381 atacaataag aaataaagta tttctcggga aagcgcagga ttccttattg ttcccgaaaa 1735441 aagcaattgt ttcgacacat gataggcgtt tgtcacaatc ggcatccgct tgaatatcat 1735501 atagagagaa cagagaggtg aagatgttgg agcgcgctgt gacttataaa aacaacggac 1735561 agatcaacat tattctgaac gggcaaaagc aggtgctgac gaatgctgag gcagaggcgg 1735621 aatatcaggc tgcattgcaa aaaaacgaag caaagcacgg cattttgaag gaaatcgaaa 1735681 aagagatgag cgcattagtt gggatggagg aaatgaaacg caacatcaag gaaatatacg 1735741 cctggatttt tgtgaaccaa aaacgcgcgg agcaaggctt gaaggttgga aagcaagcgc 1735801 tgcacatgat gtttaaagga aatccgggaa cgggaaaaac gacggttgca cggctcatcg 1735861 gcaagctgtt ctttgaaatg aatgtcctgt caaaaggcca cttaatagaa gcggagcggg 1735921 ctgacctggt cggggagtat atcggacaca ccgcccaaaa gacgagagat ttaatcaaaa 1735981 agtcattagg tggcattttg tttatagacg aagcctactc gctggcaaga ggcggcgaaa 1736041 aggactttgg gaaagaagcg atcgacacac ttgtaaagca tatggaagac aaacagcatg 1736101 agtttatttt gatactcgcc ggatattcac gggaaatgga tcattttctc tcgttaaatc 1736161 ccggactcca atcaagattt cccatctcca ttgattttcc ggattactct gtgacccagc 1736221 tcatggagat tgcgaaacga atgatcgatg aaagggaata ccagctcagt caagaagcgg 1736281 aatggaaatt gaaagattac ttaatgacag tgaaaagcac gacaagtccc attaaattca 1736341 gcaatggacg ttttgtcaga aatgtgatcg aaaaatcgat cagagcacaa gccatgaggc 1736401 ttttaatggg agaccaatac ttaaaaagcg acttgatgac catcaaaagc caagatcttt 1736461 ccattaaaga agaagcatct ggatctgcat agacctctca gtttttgaga ggtctgtttt 1736521 ttgctcgtat ttccgctttt caaagcaatc gatttgtggt atacacatgc agggtttggt 1736581 atgataatac tactgcccaa tatgcaaaag aaaggaacat ccatttgaac gaacaagaaa 1736641 cgattcagga gaaagccatt ttagtcggat gtcagctgcc gcatatcacg gatgagcatt 1736701 ttgaaaattc tatggaagag ctagcatctc tgacgaaaac agcagacgga aaagtactga 1736761 ccagcgtcac acaaaaacgg aacagggctg acgccgctac atatatagga aaagggaagg 1736821 tagaagagct gaaggcactc gtggaagagc ttgaagctga tctcctcatc tttaatgatg 1736881 aactgtcgcc aagtcagctg aagtcattgg caacagcaat tgaagtgaag atgattgacc 1736941 gcacgcaatt gatattagat atttttgcaa agcgggcgag aacgagagaa ggcaaacttc 1737001 aaattgagct ggctcagctg caatatgcac tgccgcgtct gacgggacaa gggatcaacc 1737061 tttcccggca aggcggagga attggggcaa gaggtcccgg ggaaacgaaa ctggaaaccg 1737121 accgccgcca tatcagaaat cgcattcatg aaatcaacac acagctttcc actgtcattc 1737181 gccatagaag ccgataccgt gaaagaagaa agaaaaacgg tgtgcttcaa attgcgcttg 1737241 tcggctatac aaacgcaggg aaatcaacat ggttcaaccg cctgacgagt gctgacagct 1737301 atgaagaaga cctcctgttt gccacgctgg acccgatgac cagaaaaatg gtcctgccaa 1737361 gcggctacag tgttcttctt tcagatacag taggatttat tcaggatctt ccgacgacat 1737421 tgattgctgc attccgctca acgcttgagg aagtaaaaga agcggattta attctgcatt 1737481 taattgattc ttcaaatgag gattatgcgg gacatgaaaa aacagtgctt cggctgcttg 1737541 aggagcttga agcagatgat atcccgatgc tgacggctta caataaacgt gatcaaaaac 1737601 tgcctgattt tataccgacc gccggaaggg atcacattat ggtcagtgcg aaatttgagg 1737661 acgacgctgc agcctttaaa gaagcgattc agcgctattt gcgccaagaa ctgttaacgt 1737721 cttttgaagc acatgtgccg gcaagtgaag ggaagctcct ttccagaatc aaatcggaaa 1737781 cgatggtaga ccgcttctat tttaatgaag aaaatgaaca gtatgacata tccggctatg 1737841 tccaagaaga gcaaagtatc atcggtgaat taaagaagta tatgtaggaa ggaaatataa 1737901 agacatgttt gacacattaa cacacggaga attattgaag aaaacggcaa tggaagtgga 1737961 agcggacatt gccggcattc ataaacaaat agaagaaatc agcgagcgaa atgagtggag 1738021 agtgcttcaa agctatagaa aacacaaagt aagcgacact catttcacgc cgtctactgg 1738081 atacggctat gatgatatcg gaagagacac gcttgaaagc atatatgcgg atgtgtttgg 1738141 cggagaagcg gggcttgtaa ggccgcaaat catttcaggc acacatgcca tctcaattgc 1738201 tttgttcggt gtcctcagac cgggggacga gctcctttat atcacgggca agccgtatga 1738261 tacgctagag gaaattgtgg gcgtcagggg tggagaaaac gctggttcgt taaaggattt 1738321 tcaaatcggc tataatgcgg ttgatctgac gaaagacgga aagatagact atgatgcagt 1738381 cgccgctgcg atcaatccga agacaaaagt aatcggcatt cagcgctcaa aaggatatgc 1738441 gaatcgccct tctttcttaa ttagtgaaat aaaagaaatg atccgttttg taaaagaaat 1738501 caatgaaaat ctgatcgtct ttgtggacaa ctgttacgga gaatttgtgg aagagcttga 1738561 gccttgccat gtcggagccg acctgatggc gggatctctc attaaaaatc ccggcggcgg 1738621 ccttgcgaaa acaggcggct acctcgtcgg aaaagcgaaa tggattgaag cttgctcata 1738681 ccgtatgacg tcacccggca tcggcagaga agcgggggca tctctttact cgctccaaga 1738741 aatgtaccaa ggcttctttt tggcgcctca cgttgtgtct caaagtttaa agggagcggt 1738801 gtttacagcg agattccttg aaaaactcgg cttcacttca aacccgaaat gggatgcgaa 1738861 aagaacggat ttaatacaat ccgttgagtt ttctgacaga gaaaagatga ttgctttttg 1738921 ccaggctatt caatttgcat cgccaatcaa tgctcatgtg acgccttatc cagcctacat 1738981 gcctggatac gaggatgatg tcattatggc agcagggacg tttattcaag gagcaagcat 1739041 cgaattatca gctgatggcc ctatccgccc gccgtatgta gcgtatgttc agggaggatt 1739101 aacctattcg catgtgaaga atgccatatg cagtgcagtg gattcattga tgcaaaagca 1739161 attaatttaa attttttaaa aatttctctg gatttgatgt taagaatcct tacatcgtat 1739221 tgacacataa tataacatca cctataatga aactaagtta agaaaaggag gaaattgaga 1739281 tgagtgataa tattcgccgc tcaatgcctt tatttccaat aggaattgtc atgcagttaa 1739341 ctgagttatc agcaagacaa attcgatatt atgaggaaaa tggactgata tttccagcca 1739401 gaagtgaagg aaatagacga ttattttcat ttcatgatgt agataaactg ttagaaatca 1739461 agcacctgat agaacaaggt gtaaacatgg caggaattaa acagattctg gcgaaagccg 1739521 aagccgagcc agaacaaaaa caaaacgaga agacgaaaaa accaatgaaa catgatctgt 1739581 ccgatgacga actgagacag ctcctgaaaa acgagctcat gcaagccggc cgttttcaaa 1739641 gagggaatac attccgtcaa ggcgacatgt cccgcttctt tcattaatcc gttagcaact 1739701 gttttgctat atacatttac cttttaagag gaggaatttt accaaatggc aaagtacact 1739761 agagaagata tcgaaaaatt agtaaaagaa gaaaacgtga agtatatccg ccttcaattt 1739821 actgacattc ttggaacaat caagaatgtt gagattcctg taagccagct tggaaaagcg 1739881 cttgataata aagtcatgtt tgacggttct tctattgagg gattcgttcg tatcgaagag 1739941 tcagacatgt acctgtatcc agatctaaat acatttgtta tcttcccatg gacagctgaa 1740001 aaaggtaaag tagcacgttt catctgtgat atttacaatc cggatggcac accttttgaa 1740061 ggtgacccgc gaaacaactt aaaacggatt ctgaaagaaa tggaagacct cggcttcagt 1740121 gattttaacc ttgggcctga gcctgaattc ttcttattca aattggacga aaaaggcgag 1740181 ccgacgcttg aactaaacga caaaggcgga tatttcgact tagctccaac tgatttagga 1740241 gaaaactgcc gccgcgatat cgtacttgag cttgaagaga tgggctttga aatcgaagcg 1740301 tctcaccacg aagtagcacc tggtcagcac gaaatcgact ttaaatatgc tggagcagtc 1740361 cgctcttgtg atgacatcca aacatttaaa ctagttgtca aaacaattgc ccgtaaacac 1740421 ggcctgcatg cgacatttat gccaaaacca ttgttcggtg taaacggttc aggtatgcac 1740481 tgcaatctat cactcttcaa aaatggtgtt aacgcattct ttgacgaaaa cgcagatctt 1740541 cagttaagtg aaacagcgaa gcacttcatt gcaggtatcg tgaagcacgc aacaagcttt 1740601 acagcagtaa caaacccgac agtaaactct tacaaacgtc ttgttcctgg ctatgaagca 1740661 ccttgttatg tagcatggag cgcgcaaaac agaagcccgc ttatccgtat cccggcttct 1740721 cgcggcatca gcacacgtgt tgaagtacgc agtgtagacc cagctgcaaa cccatacctt 1740781 gcacttagcg tattgcttgc tgcaggatta gacggaatca aaaacaaact ggaagcgccg 1740841 gctccaatcg accgcaacat ctatgtgatg agcaaagaag agcgcatgga aaacggaatc 1740901 gttgaccttc cagcaacact tgcggaagca ctagaagaat tcaaatcaaa cgaagtcatg 1740961 gtcaaagcgc tgggcgagca cctattcgaa cacttcatcg aagcaaaaga aatcgaatgg 1741021 gatatgttcc gcacgcaagt acatccttgg gaacgcgaac agtatatgtc tcagtattaa 1741081 tatctcaatc ccttggcact aaaagtgtca ggggattttt tatgttaata ggtaataaat 1741141 tatggagcgg cactgctaaa aagcagggtc acttttagtc tatgtcacta ataattctat 1741201 gtactaaatt tttaattagg gaaataattc cacgcttaag gaagcaatac gcataaataa 1741261 ttcgacaaat tctgtgataa ttccattgtt caatacttct accagcaata ataagatgag 1741321 taaggtagat gtttatcatt gacatcataa ccaaatgaat ccataattac gttgaaatct 1741381 aaatcaattt tcaaaaagga gatttctatg aaaaaattga ctatcttctc cgggggatta 1741441 ggagcggttt tttctgtact ggctcaactg tttgcggtta tagatgactc ttacactttg 1741501 gggaatttat ggtttttagg tgctttggcg ggaattataa ccatgcttgc ttcaatccag 1741561 acaaataata aaccagtctt cagcatatta ttaattgcta gttcagtaat aggtctactt 1741621 ggaactggtc ttgtatacat cataccaaca ctgttcaata taataataat ttataaattt 1741681 tcaaaagtaa gccaataagc caatgggaaa attaaggttc tttttttatt taacatccct 1741741 ttgacaaggt cggtgataaa tcgcagaatg tttatgcttg caactaatcc accagcgggg 1741801 gcatcggtgg gcatgattat ctaacgccat gtttctagga taccggaatt gaaacatttg 1741861 ctgaggcatt tcgtgaagct gatcaccaaa tgaccatttc catagaggca cgtctaaaga 1741921 agctatcata ggaggacaat actgtgtgga aagctttaag tcaattactc aagaaacaga 1741981 aaaatcaaag tccaagcgat gaagattata tacagattcc agaattagaa gtaaaagttt 1742041 tggggatgct tcacagtatc aatatagacc tggttaatgt aatagcccaa gcagaaaagt 1742101 ctaaggagtt tataggacaa atcgaaggca tctggcattc tatagcaaat caattttatt 1742161 cactcgccca agggtttgag aatgaggata tcaataagct ttctgcggat cttgatcatg 1742221 ctgccgccac ttgggaagct gttgctaata aagcaaaaga gtttgtaaca aattcatacc 1742281 aagggtaaaa gaaaaataag ggcctgaaag ggctcttttg cttatagtca tatttcccgt 1742341 aagtattact ttttggattt aataaatttt aaagcgtgtt tgtttcactg aattcatagt 1742401 caaaagggga atgtttttat gcttggaatc aacgttgaaa aatcaaatga aaacttaatt 1742461 atcaattggc agctatccaa aattgaaatt ccaatcaaag aaatcaatga tgtatttctt 1742521 gatccaaact atgggggaga ggagaaaagc gcagtaagga ttgggtttcc ttatggctca 1742581 acagataggg tagtaattaa aacagcacgt aacacttaca ttttgttcac cactaatcct 1742641 gctttaatta tgagtaaaat tgtttcttaa taaacagttt atgtcccttt taaatttatc 1742701 tattaatgtt ctgtgtggta aaatttagtg agatgattta aggaggagga gcatttatgg 1742761 aagaaataaa agttagttca catgacacta gatggtatta agaaagcagt ttctaaatat 1742821 ggtacattcc ctatgtttca tcatggagga tatgtcatgg aagatgctac ttttcatttc 1742881 aaagatcctg ctagtcctca agaaattagc gatatagaac agaagctagg tgttactttc 1742941 cctaatgact ataaagagtt tttgttacag cacaatggga tggaaatgtt tgatgggatt 1743001 gaaatactta gcttagaggg aatcattgaa tataatgagg ttcaagattt cccagaggga 1743061 tacgttttaa ttggatatca ttttgatgga agatatgtca tagacacaaa caaatcaaaa 1743121 aatggattag gctatatgct atatctagac tcaattgatg atattgaaga tgcgattaac 1743181 ttagattcta atttcgagat atggtttgat atgctagtgt ctttaaatgg aacgaaatat 1743241 tgggaagtaa atccgaatct ccaagagtat tataaactgg tttcagaata acacttcggc 1743301 aaaagaaaaa attatgacta atttcaacaa ccaaagaaac tgcaatttga gggaagtata 1743361 atgacaattt acgagcaaat taaggatgct ttgaaaaata agatcaatga gttggtttca 1743421 cctcaagaag taaagaaaac ccttcaagaa aaatacggaa ctaatccgga tagcattatt 1743481 ttatcagatt attgttataa ccggtataat aaggggattt cttttaataa gcacctcttt 1743541 gaatatatga atagaagttc ttacaaatac ttaggtgaaa actctcttta tacaggactt 1743601 attttcagaa aatcaaaagg ggaagataag gaagttatcg taggcgaatg ggtaaacggt 1743661 gttaaatcac tccgagaagc ttctgttact aataaccaaa taaatgatca agccgaaatc 1743721 attagtaaag aacaacttgt aaacctttat aatgaatata accaaatcct gagatatgaa 1743781 atgaatgtat tgaactgtaa gcctacagaa ttgaggcatt taattggcag aatcggtgaa 1743841 ttcatttgtg caatccaaac caacggcact ctggcacgtc aaactaatca gcatggattt 1743901 gatgttgtga gtgatggcag acggattagt gtaaaaacaa cagctcaatc aagtggtttt 1743961 atttcgataa ataaaaatac attttatgat tttgatgatt tttttgtagt tcaatacgta 1744021 aatgatgatt ttaaagttat tttcttcggc tcaaaggaag aagtgcaaaa aataagcaga 1744081 atttatggaa gccaatacga agttgaaatt tcacttctta aaaagcttaa taaggaatac 1744141 caattaaatt aaacaatctt gttggtaaca aacatcctct tacttattgt aagaggatgt 1744201 ttgtttaatt cttacatatt ttatctttgc aatctggctt acgagttgca tccacagtaa 1744261 atgatcttac ttcgtcttta gttttgtcat aaattcccca tattacccct cagagaagga 1744321 tagggggatt attttggaga atcatattcc attgcttgtt cacagtcagt aatccttgag 1744381 ttgttctagc aagaggcaat attgttgaat aagaatagtt ttaaagaggt tattgttgtc 1744441 ttcatattga aataaagatt aagtatatta gaggggagtt gctttaatgc acataacaac 1744501 aaaaaggtta ttgatacgtg aatttgaatt caaagattgg caagcagtat atgagtatac 1744561 atctgatagt aatgtaatga agtatatacc tgaaggggtt tttactgaag aagatgcaaa 1744621 ggcatttgta aataaaaaca aaggtgataa cgctgaaaaa ttccctgtca tactaagaga 1744681 tgaagactgt cttataggcc atattgtttt ttataagtat tttggtgaac atacatatga 1744741 aattgggtgg gtgtttaatc ccaattatca aaataaaggg tatgcttctg aggcagccca 1744801 agctatcttg gaatatggat ttaaagaaat gaacttacat aggattatag ctacgtgtca 1744861 acctgagaat attccctcat accgagttat gaagaagatt ggaatgagaa gagaaggctt 1744921 ttttaaaaaa tgtattccaa aaggcaatga atggtgggat gaatattatt acgctatttt 1744981 agaggaagag tggaattgaa ctttattgag tgcggcaata caaacaaatt atcaccctct 1745041 acttagaaca tattagttaa atgaaggtga tatataaagt gatatgacag tgattaaatg 1745101 ggattcaatg agctccggtg aattgttttt aggtgagttc actaaggatg atacctgata 1745161 cgcagccata ccattcgagc gttaatcatt ttataactga tcttttcact tttgcccacg 1745221 ggggaataag accctattta agtttgccag acgattgttt gatccgttgt tgatgattgt 1745281 caggattttt tgtgaaggaa tatctttata tagtggttga ttattccctt ctggtaaaaa 1745341 ttgatctatg ttgaattgct taacatgtca ttgaactcag agaataaagt gaacctgcca 1745401 cagatgttca ttatctttta gggggttcca aaaagaccgt attcctatcg atcgctcaga 1745461 gtgaaaatgg tatactaaag ttacaatcac aggaaggaat tacaattttt ttagatctac 1745521 ataaaatcat ctgattaacc gaaagtgaga atgtgtgaat gaatttaata gggtatattg 1745581 aggaaaggtt tcaaaacctc gaattaattc ctagcatcta taatcaatgg ggcacaggaa 1745641 tccatttttg tcttggggaa aatatctatc aactcaaagc aaatgaagaa ttgaatttaa 1745701 agatgtttcg gattgtatat gaacaaacct caatcatttt taatgaatta tttgaacaaa 1745761 atgatgacat attccttgtg acgaatatgt ataagcacaa aaagaaagag aaatgtataa 1745821 gaaaattaaa ggtgtatcaa ccgtttctaa aatgtaaaaa tcatttgaat caaattatgg 1745881 tgaagacata tccctatcct ttcgaaatca ataaagctga agaatacgag atgcaacaat 1745941 tttccctgtt atgcaaacct cgagacttac gtgtaactga attacttaaa gcagccagta 1746001 atgaggattt tccacaaaaa ccgaaattcg gaggttactc tattgattac cctgatgttt 1746061 tctttgtgaa cattacaaaa gacattattt tctttatcta tgatgaccgc ggatgcgaag 1746121 tcatagctca tgatttcaaa cgaatacgtc cactttatga aaaatatcac gactgggtag 1746181 aagagtataa gtgcatgtaa tacttttttt aaaaacgatt tatcaggaaa ggcagaatta 1746241 gattatgagg gccttacata caagatgtaa acggttattg aaactaagat ggtattatgt 1746301 gatgatgaga gatctgcatt tttattagta cttgatgaaa gattagtgga ttttgattct 1746361 caaggtggaa accatattag tgtttattta gttactcact ttgagttatc tgatcaatcg 1746421 tataaagatg tattaagctt taatgatgat cttttgggta tggagcataa ctgttcgtat 1746481 gcaatggata ttctaagcgt taaagaggaa cttgatttcg atttcccatt taatatgctt 1746541 gcaataaaaa gctatgtaca agaattaata aaaatgttag ggattgatat cactctgcct 1746601 gaaatgaaag aaagagattt tgacaaactt tctcaaaact aaataaaact actattttta 1746661 aagagaacgg agacttgctt tcaatatgaa tgttaaaaaa gctgcagctg ttttttcaat 1746721 cactattcca attatctcag ccatcttaat tattaatttt tttacaggat ttatgtcaat 1746781 tccatggcaa ggaatgccgg tgttttttcc attattactt tctcctatag gaatcatttt 1746841 agcgttcgtt tcaataaaga caaataaacg gtgtgctgta tatgggattg tcttaaatgc 1746901 aattatgttt ccatttcctt ttttctggtt tatcggaggg gctttgttat ttggagttta 1746961 aaatccatta ggcattacgc ttatacattg gtattttcga gcttgtcaaa agaaggaata 1747021 aaaaaacttc agaattgctt ggctttactt tatgttgaaa ggggtcgagt aaggtggata 1747081 ggaaaaagga tgaaatacaa agaaaatata gggaacaaat gagggagaag aaagaacgag 1747141 aaaaagaaga tggcagttca catacttttg aaattgttgt tgtgctagcc attatcattt 1747201 tgatgttttt ctttaattca gttttcaagg ctttttagat attgtacaga tgactttcag 1747261 gatgtttgaa aaaataaccc tttgagatat ataccgcatg aaagtattga aggacttatg 1747321 aaaattcaag agccagttga atcttaataa ttaatcacca aataatgggg atgtaaaatg 1747381 aagttgtata atgaatttat caatatagct aaaacgttta ataaagagtt agacataatt 1747441 ccattattat atggatcttt aggtcttgaa aaggtaactg ggttagactt ttccccagaa 1747501 gatattgatc tccttattcc tttaattttt ttagaggaaa agtgggaaaa actaaaaaaa 1747561 gtgatggaac tgcatggata caaaatggtt gatttacatg agcatgaatt taagaaaact 1747621 aatacaaaaa taggcatttc ttacattgag gatttaaaac catttgcaga tgtagactat 1747681 aataacctag agatttttga agatggcgga gcgaaatatc atttgctaac gattgatgat 1747741 tacctcaaga tttataaaaa gtctttatta gatggttata gaagaaggaa gaagaatcat 1747801 aaagaccaaa gtaaaattaa catattgaat aaattaatac ggaattaatt tctgtattcc 1747861 cttttgtttc cagtctcaat taaaattttt aagattaaaa taagtttgaa ggaaaaatca 1747921 tagtgtttaa cacagccatt aatcctcaga cagtcaaata gccatttcta ctccggttga 1747981 aagcttctct atttttgctt cttatttatc tttcctgtat tgatatatgt atgtagggtt 1748041 ggacttataa cataaactat tctggccatt ccgttctttc aattcatgac cgggcttgcc 1748101 atcagcataa atctaggcta acagtctcca tacatcctgt gatcaccttt atcaaactct 1748161 taaatgcaac ttaccactaa ccaattcttt atttcgcata gatcatcttt gtcatgtgtt 1748221 tacacaagaa tctgttttgg actgagacac tgaatataac aaaacagtca aaaatcaata 1748281 tttaattcat tctgtttaaa ctttctgaaa aagatgttga aaaagtcgaa aggattttat 1748341 aatattaagt caagttagtt tgtttgatca acaaactaat gaaatgaact ttcattatcc 1748401 acaagataag atcttactaa tatggatgga agggggataa gagggtcgat ttaatggagc 1748461 taaacaatat aagaaacgaa agaatgaggc ttttatcctt ttccaggtat ataaggtatg 1748521 acgaaaaaag atgaattttt tgcttgctga tcaccatatt tttttgcact gttttgaaag 1748581 cgcttttata aaagtttact gaccgtaaat tcgagaaatt gttataccgt ttcacactgt 1748641 tccatattaa aggatcgaaa aggggagaaa tcatgctcag tgaaaatgta aagaagatta 1748701 gcatggttga aaaagttgga tatgcgtctg gagattttgc ttgtaattta atttatgcaa 1748761 cagtgtctac gtatcttttg ttcttctata cagatgtttt tggtttatcg gcagcagcag 1748821 ccggtactat gtttttagtg gttagaataa tcgacgctct cgctgatcct tttatcggaa 1748881 caatagttga cagaacgaac agcagatttg gacgctttag accgtatctt ttattcggag 1748941 cttttccatt tgtcatactg gcaatactct gttttacaac accagacttt tcggatatgg 1749001 ggaaattaat atatgcctat ataacctatg ttggcttgtc gcttacatac acaacgataa 1749061 acgttccata tggcgcgtta acttctgcaa tgactagaaa taatcaagaa gttgttagta 1749121 taacttctgt tcgcatgtta tttgcgaatc ttgggggact tgtcgttgca ttttttgttc 1749181 ccttactggc tgcttattta agcgatactt ccggcaacga gtctcttggc tggcaactaa 1749241 ccatgggtat tttgggaatg ataggcgggt gccttttaat cttttgtttt aaaagcacaa 1749301 aagagcgggt cactcttcaa aaatccgaag agaaaattaa atttacggat atatttgagc 1749361 agtttcgtgt taatcgtcca cttgttgtat taagtatttt ctttattatt atttttggag 1749421 tgaattccat cagtaattcg gttggcattt actacgtaac gtataactta gaaagagagg 1749481 atttggtgaa gtggtacggt ttgataggaa gtttacccgc tttggtcatt ttaccgttta 1749541 ttccaaggct tcatcaattt ttggggaaaa agaaattact aaactatgca ttattactga 1749601 atattatagg cctcttagct ttactgtttg ttccgccaag taatgtttac ctcatacttg 1749661 tctgtcgatt aatcgctgct gctggaagtc tcactgccgg gggatatatg tgggcgctta 1749721 ttcctgaaac aattgaatat ggagagtaca ggactgggaa aagaatgggt gggctcattt 1749781 acgctataat cggatttttc tttaagtttg gtatggcctt aggaggagtt gttccgggtc 1749841 tggttcttga taagtttgga tatgtagcaa atcaggcaca aaccccggcg gccttaatgg 1749901 ggattttaat tacaacaacc attattcccg tgttcttgct tgttctagct ttaattgata 1749961 ttaatttcta taacttagat gagaaaaaat ataaaaacat ggttcgagaa ttagagaata 1750021 gagacaaagt ttatttggat catattgatg atttcaaggc ttaaaaaaga aaataaactg 1750081 aggaggagtc ccaaatgaag attaccaatc ccgtacttaa aggattcaat cccgatccaa 1750141 gtatttgtag agcaggagag gattattata tcgctgtatc tacatttgag tggtttccgg 1750201 gagtccagat acaccactca aaagatttag taaattggca cttagttgca catccattac 1750261 agagagtttc acaattagac atgaaaggaa acccaaattc aggtggagtt tgggcaccat 1750321 gtttaagcta tagtgatggg aagttttggc tgatctatac ggatgttaag gtagtagatg 1750381 gcgcatggaa agattgtcac aattatttag ttacttgtga aacgattaat ggtgattgga 1750441 gtgagccgat taaattaaat agctcggggt ttgatgcttc tttgttccat gatacggatg 1750501 gaaaaaagta tttattaaat atgttatggg atcaccgtat tgatcggcac tcatttggag 1750561 gaattgttat acaggaatat tctgataaag agcaaaaatt aatcggtaaa ccaaaagtta 1750621 tatttgaagg aactgataga aaactgacag aagctccgca tctttatcat atcgggaact 1750681 attattattt attaactgca gaaggaggaa cacggtacga acatgctgct acaattgctc 1750741 gttctgcaaa tattgagggg ccatatgaag ttcatcccga taatccaatt ttaacgtcat 1750801 ggcatgaccc aggaaatcca ttgcaaaaat gtggtcatgc atccattgtt caaacacata 1750861 cagatgagtg gtatttagct catttaacgg gacgtcctat tcatcctgac gatgattcaa 1750921 tttttcagca gagaggatac tgtcctttgg gcagagaaac agctattcaa aaactttact 1750981 ggaaagatga atggccctat gtagtaggtg gaaaagaagg aagcttggag gtagatgcac 1751041 cttctatacc cgaaacaata tttgaagcaa cgtacccgga agttgatgaa tttgaggatt 1751101 caacattaaa tataaatttt caaactttaa ggattccatt cacgaatgaa ttaggttcat 1751161 tgactcaagc gccaaatcat ttacgattat tcggtcatga atcattgacc tcgacattta 1751221 ctcaggcatt tgtagccaga cgctggcaaa gtctccattt tgaagccgaa actgctgttg 1751281 agttttatcc ggaaaatttt caacaagccg ctgggttggt gaattactac aatacagaga 1751341 actggacggc tcttcaagtc acgcatgatg aagaacttgg gcgcattctt gaattaacaa 1751401 tatgtgacaa cttttctttt tcacagccat taaataataa aattgttatt cctcgtgaag 1751461 taaagtatgt atatttaaga gtaaatattg aaaaggacaa atattattat ttctattctt 1751521 ttaacaaaga agattggcac aaaattgaca ttgcactgga atcgaaaaaa ttatcagatg 1751581 attatatccg tgggggagga ttcttcacag gggcctttgt agggatgcaa tgccaagata 1751641 ccagtggtaa tcatattccg gccgacttta gatattttcg ttataaagaa aaataatttg 1751701 cacatgaaaa aggagatttc tattttagaa ctcctttttc atatgagaag gtgccatgtc 1751761 actattgctt cagaaatact cctagaataa aaaaactcat ctttaaagat gagctgtcca 1751821 ttccataaaa aattacattg taatcatgtc cagaaaatga tcaatcacaa tggaggacat 1751881 tcctaatgcc ggtgcattct gtcctaagga agatggcaat aattcatagc tattgcctaa 1751941 ttgggaataa acccttgatg atacttcact tctcattgaa tttaaaacca taggatgcga 1752001 ttcaattatg ctatttctta aaattacggc ttgtgggttg aaagtattta gaatattggt 1752061 aaggcctatt cctaaataga atccaaaatt ttgtaatgca tttaaggttc cgatatcatt 1752121 cagatgggcg aggtttatga tatcttgata ggacagtttt ttctctttgg tctgaagaga 1752181 ttttaataaa gccttctctg aagcatacaa ttcccagcat cctcggtttc cgcaactgca 1752241 tttaggacca ttaaagtcta ttgtcatatg tcccatttct ccagagaagc cgcttactcc 1752301 tctatataaa tgattgttga taataacacc gatccctatt cctgtgctga tacttacgta 1752361 aataatgtta tcgtgatttt ttgcagctcc aaatactttt tctccatatg cgccagcatt 1752421 tgcctcattt tcaataaaaa caggcacatt gtacttctct tgtatcgaag attttaagtc 1752481 aatatctctc cagttggagt tcggagtgaa aacaattttt tgatctttat caatgagtcc 1752541 aggcacgcaa atacctatac caataagccc gtacggagat tggggcattt gcgtaataaa 1752601 gtgatgaatc atatcaatca aaatgtcttt cgttatttct ggagaattgg attccaaatg 1752661 gcggtattga tcaagaacga ttgttccttc aaggtctgtt aaaatgccat taatataatc 1752721 cacaccaaca tctattccaa cggagtatcc tgccttttta ttaaaaacaa gcatgacagg 1752781 tcttcttccg ccacttgatt gtccttgacc tatttcaaat accatacttt ctttcattaa 1752841 cgtgtttacc tgtgatgaga cagttgattt atttaatcca gtcatttcag ataattttgc 1752901 tcttgaaata ggtgaatttt taaggatttc ttttaataat aacttttgat ttactttttt 1752961 gacaaaggtt tgatcagcga tatccacttc atccactcca tttgtttaat ctttaaatta 1753021 agtatcaaca tagtacatag cgaatcttcc ctttattata tctaatgtgt tcataaaaaa 1753081 ctaaaaaaaa tattgaaaat actgacgagg ttatataaga tgaaaataag ttagtttgtt 1753141 taaacaacaa actaataggt gatgtactta ctatatgaaa taaaatgcat ctgtatttga 1753201 atgaatttat ttttaagggg gaaatcacat ggctcaatct cattccagtt caatcaacta 1753261 ttttggaagc gcaaacaaag tggtttacga agggaaagat tcgactaatc ctttagcatt 1753321 taaatattat aatcctcaag aagtaatcgg cggaaaaacg ctgaaagagc atttgcgatt 1753381 ttctattgcc tattggcata catttactgc tgatggtaca gacgtttttg gagcagctac 1753441 gatgcaaaga ccatgggatc actataaagg catggatcta gcgaagatga gagtagaagc 1753501 agcatttgag atgtttgaaa aactagatgc accattcttt gcttttcatg accgggatat 1753561 tgcaccagaa ggcagtacgc taaaagagac aaaccaaaat ttagatatga tcatgggcat 1753621 gattaaagat tacatgagaa atagcggcgt taagctatta tggaatacag caaacatgtt 1753681 tacgaatccc cgtttcgtcc atggtgccgc gacttcttgc aatgcagatg tgtttgcgta 1753741 tgctgcagca caagtgaaaa aagggttaga aacagcaaaa gagcttggcg ctgagaacta 1753801 tgtattttgg ggcggccgtg aaggatatga aacattgtta aataccgatt taaaatttga 1753861 gcttgataat ttggctagat ttatgcatat ggcagtggat tatgcgaagg aaatcgggta 1753921 cacagggcag tttttgattg agccaaaacc aaaagagccg accacccatc aatacgatac 1753981 agatgcagca acaaccattg cctttttgaa gcaatatggc ttagacaatc attttaaatt 1754041 aaatcttgaa gccaatcatg ccacattagc cgggcataca ttcgaacatg aattacgcat 1754101 ggcaagagta catggtctgc ttggctctgt tgacgcaaac cagggtcatc ctcttttagg 1754161 ctgggacacg gatgaatttc cgacggattt atattctacg acattagcaa tgtacgaaat 1754221 cctgcaaaat ggcggccttg gaagcggcgg attaaacttt gacgcgaagg tcagaagatc 1754281 ttctttcgag cctgatgatc taatatatgc ccatattgca gggatggatg catttgcaag 1754341 aggattgaaa gttgcccaca aattaatcga agatcgtgtg tttgaagatg tgattcaaca 1754401 tcgttaccgc agctttactg aagggattgg tcttgaaatt atagaaggaa gagctaattt 1754461 ccacacactt gagcaatatg cgctaaatca taaatcaatt aaaaacgaat ctggaagaca 1754521 ggagaaatta aaagcgatat tgaaccaata cattttagaa gtataacagg ataagctcca 1754581 gatcctgcta tcaataccaa gtcactgaat tacccgtcat gattcctttc ctattgcttg 1754641 ttgttatgac gggtaacttc tataattagg atttatttag agtgaatggt tttttaaaag 1754701 ggcaaggagt gaaaaaatga agtatgtcat tggaatagat cttggaacga gtgctgttaa 1754761 aaccatttta gttaaccaaa acggcaaggt ttgtgcagaa acgtccaaaa ggtatccgct 1754821 catccaagag aaggcgggat atagtgagca aaatcctgaa gactgggttc agcaaacaat 1754881 tgaagcattg gctgaattgg tttctatatc caatgttcaa gccaaggata ttgacgggat 1754941 aagctattcg ggacaaatgc atggattagt actgcttgac caagatcgtc aggtgttacg 1755001 taatgcaatt ctttggaatg ataccagaac aacgcctcaa tgtataagga tgaccgagaa 1755061 atttggcgat catcttcttg acatcacaaa aaaccgtgtt ttagaagggt ttacattacc 1755121 taaaatgtta tgggtaaagg aacatgaacc tgaacttttt aaaaaaactg ctgtgttttt 1755181 gcttccgaaa gactacgtgc gattccgtat gaccggtgtc attcacaccg aatactccga 1755241 tgcagcagga actttacttt tacatattac tcgcaaggag tggagcaatg atatttgcaa 1755301 tcaaattggt atttctgcag atatttgtcc tccgcttgtt gaatctcatg attgtgtagg 1755361 atcgctgctt ccgcacgttg ccgcgaagac cgggctatta gaaaaaacaa aagtgtacgc 1755421 tgggggagca gataatgctt gcggcgctat tggagcaggt atcctttctt ccggaaaaac 1755481 attatgcagt attgggacgt caggggtcat actttcctac gaagaagaaa aagaaagaga 1755541 ctttaaaggg aaagtccact tttttaatca tggaaaaaag gattcttttt atacgatggg 1755601 cgtcacgctc gctgcaggat acagcttgga ctggtttaaa agaacgtttg caccaaacga 1755661 atcgtttgag caattattgc agggggtgga agctattccg ataggagcca atggactgct 1755721 atacactcct tatttggttg gtgaaagaac gccgcatgct gattcttcta ttcggggaag 1755781 cttgatcgga atggatggag cccataatag aaagcatttt ttgagggcaa taatggaagg 1755841 tatcacattc tctttacatg aatcaattga gctattccgc gaagcgggaa aatcagttca 1755901 tactgttgtt tctattggtg ggggagctaa aaatgatacg tggctgcaaa tgcaagctga 1755961 tattttcaat acgagggtaa ttaagttaga aaatgaacaa gggccagcta tgggggctgc 1756021 aatgctggct gcctttggaa gcggttggtt tgaatcactt gaagaatgtg cagagcagtt 1756081 cattcgtgag gctgctgcat tttatccaaa ggcgcaaaat gttcaaaaat ataaaacact 1756141 atttgatttg tataagaaca tttacactca cacaaaggat ctcaatacag ctttgaagag 1756201 ctttcgaaaa aactaatgat gttattgtct ggagatcaac cgaagaacaa ttaatgatca 1756261 atcatcatca aaggcctttg ataacatggc tgccttcttt tgaaaagatg gtgagaataa 1756321 ggtatcgcaa cctttaaaca gtattggagt atccagcaga caaaacgaac gagtggaacc 1756381 gtattttgtc agcgaacact tcaagaagtg gggaagctta ggaatgccaa tgggtaagat 1756441 gtatgaaacc gcgctaacga cggtagaggg atctcttgat ttatgaagaa ataggaagga 1756501 tgttaacaca caaataaccc ctcacattga cgtgaagggg tgttttttat tgttactata 1756561 cagcggaaat tttacaggct agttgcatga ttttagcttg ttaagcagaa tggaactaga 1756621 ctctccatca tctctttctc attctttgga aactgcattc tgctaggttt gctgcttttt 1756681 ttaacaaaca gtgtttttct atttcacaca gccattaaat cctctgttcg tcacataacc 1756741 gctcttactc caaattgaca gtttatctga ttttgcttct tgctcatcta gtctgaattg 1756801 gtctatgtat tttgtgttag gctcatatac atatgctact ctggccaatc cctctttcaa 1756861 taatgtctct tgaacagatt tgccgtcaac ataaacgtat gctaacagtc ttccatactt 1756921 atctctgcga tcgcctttat caaattccag ctgtagctta ccgctgttga ccaattcttt 1756981 atttcgtttc gacgcatcct caccgtatgg ttgaacacaa gaatttggtt tcttcgtctc 1757041 aggtgtatca acgagcaagt agcgaactgt gtctttcttt ccgttgtaaa taaccttaat 1757101 cgtatctcca tctattgctc tatctaatgt aacattgacc aatttcttct gattttttga 1757161 atgaggcgtg ccagcctttt gttctgtctg attatattca ttagagtgag tatcttgaga 1757221 gacttgctcc gtcccattag aatctgaatg gtttttggct gcgtgatttg atccgcaagc 1757281 tgccaaagta atacttaaaa cgattgcgat catactgatc aaaatcttct tcatattgat 1757341 tccctcttta tcattttctc ttttcgcgat taaacatcat cattataacg atatggacat 1757401 tttttgtgaa tggaaaactt caagggaact tataacactc caaattgcca atagttaact 1757461 tcacaacgag atgatcaaaa catcaccatc acatagcgga aataaataat cctgaaaata 1757521 atattgactg aaaatgcttt tagaattatg ataatatgag aaatgacaat aatgtgacaa 1757581 agacattact acaacataac aactaatagc ttaggtttat tctattggtt aaaaatgtaa 1757641 acggttacaa atccagaggc gaaaatctaa gatagagatg actttagttt tgactcaata 1757701 tccacactga aagagcttat taagtattct taaaggcagg ggaaatggat atgaatgaac 1757761 atcgaaatcg aaggttgaaa ttaataatga tttcagcaac ttttggaggg cttctctttg 1757821 gatatgacac cggagttata aatggagctt taccttttat ggcaaggcca gatcagcttg 1757881 atttaacacc tgttacagaa gggcttgtta cgagtattct tttattaggt gccgcgtttg 1757941 gagcgttgtt atgcggaaga ttggctgatc gatatggccg ccgtaaaatg atccttaatc 1758001 tttccttttt atttttcctg gcatcactgg gaacagcgtt agcacctaat gttttcatca 1758061 tggcggtctt tcgtttttta ctggggctgg ctgttggagg agcctcggcg atggtgccgg 1758121 cctttttagc agaaatggca ccgcatgaaa agagagggcg tatggtaacc caaaatgaac 1758181 taatgattgt tggcgggcaa tttttagcat atgtttttaa tgcgatcctc ggtgtaacaa 1758241 tggcaaatac gggacatgtt tggagataca tgctagtcat ttgtgctgta ccggctatca 1758301 tgttatttgc cagtatgctt aaggtaccag aaagcccccg atggctaatc tccaaaggca 1758361 aaaacagtga ggcgctgcga gttcttaaac aaattcgaga agataaacgt gcagaagctg 1758421 aatgtagaga aattcaagaa gcggtagaaa aagatacagc actagaaaag gcatcactca 1758481 aggacttttc tacaccatgg ctgcgccgtc ttttatggat tggaatcggt gttgccatcg 1758541 tgaatcaaat tacaggtgtg aactcgatta tgtattatgg cacacaaatc cttaaagaat 1758601 ctggttttgg tacaaaagcg gctttaatcg ctaatattgg aaatgggctg atatcagtta 1758661 ttgcagttat atttgggatt tggctggtcg gaaaagtgag acggcgtcca atattattga 1758721 ttggtttggc agggacgact acagcgctcc tattgattgc gattttctca attgtgcttg 1758781 atggatctat ggcacttcct tatgtagtgc tttctttgac cgttttattt cttgccttta 1758841 tgcaagggtg tgtaggacct gtgacttggc ttgtcatagc ggaaatattc cctcaaaggt 1758901 taagaggact tggttctggg ataagtgttt ttttcctttg gatattaaac tttgtgatcg 1758961 gttttgcttt cccgatcttg cttagctctg taggtttgtc ttttacattc tttatatttg 1759021 tggctttagg tgtattggca atcggttttg tgtacaaatt catgccggaa acaaaagggc 1759081 gtacacttga agaattagaa gagcattttc gttctcgaca cgatcataat actcctgaac 1759141 aatcagttat tgaggtataa atatgttgaa aatctctctt cttataggag ggattttttt 1759201 agtttcagaa aaaacaaaat ccctctggta gagggatttt gattcagcat tttaagatgt 1759261 tctacacgta taatactgga gttgatactt taaaaatctc gccatctctt atataaaaac 1759321 gagggatgcg gcggcttaat gtagacacga cttcatagtt aatcgtattg agcatttcag 1759381 ccacttcatc aacggaaatc tcggctcctt tttgcttacc gtaaatcacg acttcatctc 1759441 cttgtttacc ttcaccgttt tctcctaaac tgaccatgat catatccatt gttactcttc 1759501 ccgccactgg cactcgtttt ccgcgatgaa gaacaaaccc gcgattggaa agggcacgag 1759561 aatagccgtc agcatagcca atcgggagtg tagcaattac ttcattaggt tctgcgatgt 1759621 atgtagcacc atagctaacg gttcggggtt ctgtccgcat ggttttcaca taagcgatgc 1759681 gtgcctttaa acttaacgca ggttcaagct taacgagatt tagttgttta atataggctg 1759741 aaggatataa accatataag ccgataccta aacggatcat atcagcgcta aattccggaa 1759801 atgcgatagc tgcagccgtg ttgcacatat gcacggtggg cagctcaatc ccctgttttt 1759861 ttaaaaagct gagaaaactg atgaattttt catgctgcag ctttgtgagt gttgtgtccg 1759921 gttcatcagc tgtcgaaaaa tgtgtgaaaa tccctgtcca tctgaggaat ttacttgcct 1759981 ttaaggcttt cactacctct aaaagttctt cctttgtgcg tacacctaat cgtcccatgc 1760041 cggtatccac gttaatatga atggccagcc ggttagcact cgcttctttt tccaatatct 1760101 cgtttgcttc tttcatccaa tcaacctgaa atgctgataa tgttatattc caagctgctg 1760161 acttctttac acaactaagg gatgtaaaac caagcacaag gataggtgct gtaatcccag 1760221 ctttacgtaa aacgattcct tcctccacac tggcaacagc gagctcactc gccccgtgtt 1760281 ccagtgcatg gcgtgccact tctatagacc cgtggccata accgttcgct tttacaacag 1760341 ccataatttt gctcttatgt ggaatatgac ggcggatcgc tcgcaaattc tttttaacgg 1760401 catcaagatt gacttcgatc caaacttctc ggcaaagctt tatcatcaac gcttccttcc 1760461 ttcttatgga ttataaatac cacctattgc cgcaagaata aatgttaatt gttggatgat 1760521 tcgatcttat tttattcaac tttatttgaa atcattcaac agcaaatcca tgtgatacga 1760581 gaaggtgcct atcaatgttc gaataatagc aagtacggga tacatgaggc ttgtaagtgg 1760641 ggtgttaatg gatgcggcga ccgaggatta caaaaatgat tatttgtttt gggacatttt 1760701 tttctaaggg tagatgataa cgagaaatct aatcaggaaa tacttaccgt tgttatgaac 1760761 attgaagaac cttttaaatg agaagggctg aggaaattct gtaaaagata atcggttgaa 1760821 aaggcagtcg attccttgtt ccataaacct aacatcagag tatataatta tactcgtatt 1760881 cacaaaaatc gtttaagtaa ggggtataca tgaatagggg agttagtttt caaataccga 1760941 atgaatatgg aaattttcta tggagaatac tgcagccggt agaaatagct aattataggt 1761001 ggcaaacgag tggggaatct tattttgttg tagaaggaga gctcgatgat gaggagcttt 1761061 ttcatgacta cgaaattgtt gagggggcag tttttgagca acaattaaaa acgaatcagt 1761121 actataccat tttcgttgaa ctgaaagcat ttccatatgg aaaaatggtt aatcaagtca 1761181 atacatatga agagtttgct gacagtgatt gcgaacttgt ccttttgata gcagataata 1761241 gctacgtttc gatttactgt aaaaacaaaa atatcattga aaaactttac ttcaatgctt 1761301 tacagcatga ttttgaagac gttcaattta taactgatga aaatgacaca agaacaagcc 1761361 ttactgtatg atactcaata aaaattaaag gagctagtac atgacaatgc aaattaaaat 1761421 caagtatcta gatgaaacac aaacaagaat cagcaaaatt gagcagggag actggattga 1761481 tcttcgggca gctgaagatg taacaatcaa aaaagatgaa tttaagcttg tcccattagg 1761541 tgttgcaatg gagctgcctg aaggttacga agcacatgtc gtccctcgtt caagtacata 1761601 taagaacttt ggcgttattc aaacaaattc aatgggtgtt atcgatgagt catataaggg 1761661 agacaacgat ttctggttct ttcctgctta tgcattgcgt gatactgaaa ttaagaaggg 1761721 tgatcgtatc tgccagttta gaatcatgaa gaaaatgccg gcggttgaat tggttgaagt 1761781 cgagcatttg ggaaacgagg atagaggagg actcggttca acaggtacga agtaaacaaa 1761841 ataaatcctt ggctgtcttc atgctgtgtg attgatcaat ggaggtttca gccaaggtac 1761901 atataaatat tatgtataaa atgaatattt taatacgaag gatttaatta aaaacaaagt 1761961 ttaaaaaggg aagttttgaa aaagtgaaat agtaataact aaagtcgata aagaacctaa 1762021 agatgtcaaa gaaacaattt ttctggtgct ttgctttttt gaaggtttac ttagctcgtg 1762081 gataactgcc ccccataaaa gcatggatgc taaaattata atacttatat acataaagat 1762141 gctcctttta ttatatttac agtttttaca tttttatcga ttttaccaca tttaggattg 1762201 agttgtcgat gaaacaagca tctctataaa gaaatacttt tatctaaatt tttataaata 1762261 ggggaaggca actaaaaact agtaatgcca ctaataataa gccaagttaa atgacttgtg 1762321 ttcattaata attgaatttt acagcagcca tgagcacaaa aaaatctgag ttcgtcgata 1762381 aatatcataa aaaagccccc ggtatgtcgc cagggaataa atagacgttt aagagattta 1762441 gtgatgtttt ttatatgatt cgacaaaatc ataataatga tcatcgtcat cataatactt 1762501 tttttcgtaa tgataatcgt gatcatcgta atacttttta tcatggtcat catacttttt 1762561 gtcgtaatca taatgttttt tatcatgatc ataatacttg tcgcaatcat aatgcttctt 1762621 atcattgtcg taatactttt tgtaatatgt ttttttccaa gtataatact cttctttata 1762681 ttttttataa taacccaatt aaattcctcc tttatgttat tcgaatttaa tttatgaagt 1762741 ttaaatgata tggtatggtc aaatgaaata agaatagtaa aaagaggctg tttaaaacac 1762801 tttctgaaaa acaaaacgga tagctgttta tgaaaataag agcgagagag agcactcaat 1762861 cactgtaaaa taatagtaaa gtgtatagag agattagtat acgtaaaaag ggactttctc 1762921 attgaagaat atttgaacgt tatggttaag attcaagagc tctatgatgt gatttttcac 1762981 actgcttttg aaggatttag agttagacat caaaaacaaa cagcaaaacc ggctagaaac 1763041 agatcatata aggaatgaac cgctgccaaa tatcataaaa aagttgttaa tgatcaaatg 1763101 aatgaaatta gagagaattt attttaaaga aagcccaatt gcacatggac aaatgacaat 1763161 tgatattgag gtaaaataca atgcattaaa tcagaaaaag ctattggagg atttaatgtg 1763221 tttagacaat ttccaatttg gtatacacaa acacctgact atttgaattt ttatgtaccg 1763281 caatatcaaa ccatttcgta taatcctcaa caatgttatc aacggtgtat gtaccaaact 1763341 ggcggtaact atgagctatg tgacagacta tgttatggag aaatacaggt gtaaaagagg 1763401 gggattaact cctctttaaa cacacagtga gtggaataag atcctcactt tatctgcaag 1763461 tgcttagtat ttgcgataat attgcattcg taataaatta tgcttagcaa ctgaaaatga 1763521 aagaaggata tgaatagtca tgacgcaatt cgataaacaa tacaattcaa ttataaagga 1763581 tattatcaat aatggaatct cagacgaaga gtttgatgta agaaccaagt gggactcaga 1763641 tggaacaccg gcacatactc taagtgtaat cagtaagcaa atgagattcg acaactcaga 1763701 ggttccgatt ttaacgacaa aaaaggttgc ctggaaaaca gccattaaag agttgctctg 1763761 gatttggcag ctgaaatcta atgatgttaa tgatttaaac atgatgggcg tccatatttg 1763821 ggatcagtgg aaacaagaag acggaaccat cggacatgca tatggatttc agctggggaa 1763881 gaaaaacaga agtctaaatg gagaaaaagt ggatcaggta gactatcttc ttcatcaatt 1763941 gaagaacaat ccatcttcac gcagacacat tacaatgctg tggaatcctg atgaattaga 1764001 cgcaatggcc ttaacgccat gtgtatacga gacacaatgg tacgttaaac atgggaaact 1764061 ccaccttgag gtaagagcac ggagcaatga tatggcattg ggaaatccat tcaatgtatt 1764121 ccagtataat gtgttgcagc gcatgattgc tcaagtgact ggttatgagc ttggtgaata 1764181 tatctttaac attggggatt gccatgtgta cacacgtcat atagacaatt tgaaaattca 1764241 aatggaaaga gaacagtttg aagcacctga actatggatc aatcctgaag tgaaagattt 1764301 ttatgacttt accattgatg atttcaagtt aatcaactat aaacatgggg acaagctttt 1764361 atttgaggta gcggtttaat gctgcctttt tattgtgcag tgaatagata gcaggtatcc 1764421 taatttcatt aagcaatctg gaagatgaat aaaaattgaa ggacaaacac gtataataca 1764481 taaaaaagat taactctaca gttaatcttt tttattcaga agaaaatatc ctaactttga 1764541 aactaaatac aaagtaaaag caatcattac agttctagat attacaattc catgaatagc 1764601 tagatcatat ccagcaggta tcaacgcatt tgtattacac ataaaatata tagatattag 1764661 aagtgctaca ataactaaaa tcattccaaa aagacttgtt ttttcatatt tcataccaat 1764721 ttccaccctt attaaagtta ggtttaaaca aaagagctga agaaacgaac tatgaccagt 1764781 atgctccaag gaaaaccgcc agacaatgct ggcggctttt tgctgcttcg tttatttatt 1764841 aacagagatc gtaacgttat ttcctgcaac tgaaaccttt gcgaaatcct gtgtatctac 1764901 cacaggagtg acggctttat tgtcgatagt gatgttgtta aaagaggtcg aaaaggttgc 1764961 tttgatcgca tcacgctggc tttcatacga aacagccgcg gtagcaagtg ttttccattt 1765021 tgaaatcgtg ccgatgttgg ttccttgaat ttctgtgata atccgtccgg tgtagccgtc 1765081 attgttcgtt ccccaaaggg tcatgcgcgt attgccgctt aaatttttat agattgtcat 1765141 ttggactgtg cttccagggc ggaagccttt attgtatgtg aatttgtctt ttccttcgat 1765201 gtacgtttct tcatttttgg acccaacctt catgaggggc ttccagacgt tgtattgttt 1765261 gctgtactga agcccgatat cggcttcagt tccgcttgtt gccctaaagc cagaataaat 1765321 atagggagta gagaccgagt cgttgttttt gacagtttca ggaagcacga ttttagctgt 1765381 aaaaacggcg cccgtactgt tcaggtagac acggccgccg attccgttag gcagctcgga 1765441 tgctgctttt gcgacttgag cgtctgccgc gggtaaacct ggtatacctg atgaaagggt 1765501 tccgaaaaga actgctgttc ctactgcacc tgcaatcaat acttttttca ccaaaattcc 1765561 cccttttgat agtggtttcg ccatttatta taccttattt tggaactgga tttacgtata 1765621 taaatcgaca aaatatttca ttttgaatga tgtaaggtcg aaacgcttcg ccaatctgaa 1765681 agctatatac ctttatcaga ggaaagaatg agatcacatt cgttttaacc gatttgaaat 1765741 tttcctcaaa ataaaagtac aaatgcttaa agaaacgatt attaaaagaa tgcccgctat 1765801 cgtttccaag cctgtaaaaa agaggtgacg tttcatcaat gtctgtcctt gtaaaatgat 1765861 aaaagcacag ataccgacta agaaaagaaa acaaatactt aggattgcta acgctttacg 1765921 tgagtatgtt ttcatttcat ctttaaaata cagcaatacg aaaataaagc agataacatt 1765981 ggctattgtt ctaatcacct caaagctttt catgacaact gatataaata gacaaagtaa 1766041 aatgagataa aatacgatgt ttctatacaa aaaacctctc cttttatgta ggatcctcaa 1766101 agagtttata aaagtttctt tgtaactgca ataaattgaa tgcgctcact tatgaactaa 1766161 ctaaactatg tactaaatat tcactattct ttttcagatt cagtcaccaa ggttttcata 1766221 gaaagggaag cttcagaaat atacatatag tgcacaaaca aaaaagaccc ggcaatagcc 1766281 gggggaaagt aaaaacgagg agatgttaat ggcgtttagt agtgtttttt atgcttttta 1766341 tactctacaa cataatcata gtctttttta tcgtgatcat aatatttttt atcatagtca 1766401 tcatattttt tgtcgtaatc acagtcataa tcttttttat catattcgta atacttctta 1766461 taatacgttt ttttgaccgt ataatactct tctttgtatt ttttgtaata acccatatat 1766521 actcctcctt tatttttact acgctttatt atacggcgag tagattttgc ggcttggaca 1766581 gttaaaatca tagaaggaaa aaagggctgt ccaaatgata gaaaaagaca gatgacacaa 1766641 aaacaaatca aaataaagag ccgatttttc atcggcccaa acgatttatc ctacatttgt 1766701 ttgtcttctt tgttttctga gtcatttttt ctgatatcct gagtcagtcc gcttgttgct 1766761 tgtttaaatt ctgataaggc ttttcctgct gcacggccaa gcgccggcag tttatcaggc 1766821 ccaaatacta aaaaacccac aaacaaaata acgagtattt ttgtgaagct taattccata 1766881 tccttttccc cctgattgaa gtacaacctt ttaaacaaat tataagagat agcagtacaa 1766941 atgggaatgc atttattttg aacattttaa aaccagcaca aagacggatt cataaaacgg 1767001 ctgctgctga atataatgtc caatgccacc tgcctaagaa gcaggaggca ggctggatca 1767061 attatgtagc tctgccggaa atgatacaaa cgtagcggct atcattgaca tagaggagtg 1767121 gtgtagctga tgagattcac taaggtagtt ggatttttgt ctgttttagg gttggctgcg 1767181 gtttttccat taacggcaca agcagaaaaa gccggaactg cgggggctgg agagtgggat 1767241 aagttgggga cttacacata tacttactca agtccgacgg tatactcgac cggaggagat 1767301 tttagagtgt gcctttcagg aagcactcct ttttctgttt cactgcactt atatgaggat 1767361 gatcccggtg acaatcctga tgattatgta ggggcaaact atttttcacc cggagaatgc 1767421 cacacctttg gcagtattgg aaaatttgta gatgggagca ataacaaggc cgagttcttt 1767481 gttaccgatt actctggtaa atctaaaact gttacgtttt atgattgatg gactcaaatt 1767541 gtgaagtata acccttggaa aaaaacaaaa aagagagata cctctctctt ttttattctt 1767601 cgacagcctt acgaagccgt tcatttacaa tgccagtcca gccgccatcc atcttaccgc 1767661 gaacgacgga gcttttctcg tttgctttgc cgatcacttc attcggctct ttccagccgc 1767721 tgtgaataag ggtaaaccct gtcttttccc ccaagtcttc taattgaaag gtaacgaccc 1767781 atccttctgt atcccattca aaagaaagtt cagttggagc ttgaacagcc aaaactttac 1767841 aaggggacgg cccaaacggc gattgtaagt gaaattcttg tccttctttg agctgaaagt 1767901 cattgggcat aaaccacttg gcaatgcctt ctgaagtaga gactgtctcc cagactttct 1767961 gaatgggagc ctccagagta atgctttttg taatatccgg taatgcattt tcgttgtttt 1768021 gagccatttc gtttacctct tgacatatga tgttttttca attcaatcat ataataacta 1768081 ataagatcat gtccatagcg tgcattattt atgctagagc tgctgttgaa cagcgtgtca 1768141 gtcgccagtc tgatctgtga atgggagaat tctgcatgcg cgaaaaagag agagaggtgt 1768201 atgttgtcat ttcgttcatt cttgtttgca gccgcaactg ttatgtttga actgggattc 1768261 ctgttcagcc aatttatttt gcgatttttg ttttaatagt aaatgagcca ttttctaaaa 1768321 caggaggttt tttatgcttg gaaaaatcaa agcagccatt gataatagtc cagggaagcc 1768381 ggccagaatt ttagttagtg aaaaagcgtt tcagcaatta gaggaagaaa tgcgctttgt 1768441 ttacgtttcc aaaccgaaaa cgataatggg gattcctgtg gaagtttcag atcaggcaga 1768501 aagcttcaag ctggaatttt agttttccca gactgctaaa aggctcattt tgtgttaatt 1768561 atgcaaaatg gtcaggttga tttctttaaa agcatgatga aatgttcatc atgctttttt 1768621 attgagaaaa aagacgaaca taaaaaatag gtatacggga aaaataatcc tattagagag 1768681 aggggaactg acagatggat aacatgatat caacacttac tgactggaat gtgtggtttc 1768741 aagcgttagt agtatttctc gttccatatg taatctataa agtgtttact tggattcatg 1768801 tataagaagg tgcaatgatg aggtggcgga acaatcagta caaaacacag aagcagcata 1768861 aatcagatta ttcgacagct gaaaagcagg atcaggatgt gttaaccggt aacatcggat 1768921 acgacttaga acatgtaaaa agaaaaatag gacataacgg ggacgttcat ttccgtgagc 1768981 ttgaaatcac tcaattacat gtgaaagcgg cattgatctt tgttgaagga ctgtctgatc 1769041 aggacttgat taataaagga ctatcagtgt tagtcatgaa tcaacctaat caggtaagcg 1769101 atgaaatttc tcaatccggc aaaggtattt taacttcgaa acagataaaa aatcaaatcg 1769161 tatcaatcgg tgatgtcata gattcagaga aaatcagtga tatcgtgttg aatgttttca 1769221 tgggttcgac agcgcttctc atcgatggaa taccgcaggc ctttcttctg ggaactgtaa 1769281 aaaaacaaaa tcgaagtatc gaggagccgc tttcagaagc gcttgtcaga gggccgcgca 1769341 caggctttac agaagagttg agtacgaata cagctctttt gagacagcaa ggaaaaaatg 1769401 atcaattaac attgcagaga tttgaagtag gaacacgatt aaaaaaggat ttaattatcg 1769461 cttatatgaa tgacattgca gatccaaaag tagtcgagga agtaagaaaa agagtgagag 1769521 ggattgagat cgatcatttg ccggagtcag gctacgttga acagttaatt gaggataatt 1769581 atttgagccc gttcccgcaa gtacagagta cagaacgtcc tgatcgcgtc ataagcggat 1769641 taatggaagg aagagtagct attctgcttg acggcactcc gtttgctttg attgttccag 1769701 tcactttcag catgatgctt caatcgcctg aagattatta tgaacggtgg ttcccgagct 1769761 cgctcatcag attgctgagg ttcatcgcag caatgataac gttattcgca cccgctttat 1769821 atatatcatt tatttctttt catcctgggt taattccgac caagctggcg atttcaattt 1769881 ccgggacgcg ccaaggtgtt ccgttcccat ctctgattga agccttattt atggaagtcg 1769941 cgattgaaat tttaagagag gcggggcttc gtttgccaaa accaattgga cccgcaatag 1770001 gcatagttgg cggattaatc atcggggaag cagctgtgca ggcggggatt gtcagtccaa 1770061 tcatggtcat tgttgttgcg ctcacagcaa tttcttcatt tgccatcccg cattatagca 1770121 caggtatagc acttcggatg cttcggtttg gcgcgatgtt ttgtgcggcg gtgtttggat 1770181 tgtttggagt cattatgtat tatctgctgc taagcagcca tgtcgtaaag ctaaagagct 1770241 ttggtgtgcc atacgcaagt ccggcagtgc cctatcactt aaaagattgg aaagactttg 1770301 ttatcagaat gcctctttta gtcatgaagc gccggcctaa aatgatgaat acagataata 1770361 caaaacgggt gaagtgatga actcgacagg atggtgataa agtctcatgt tcagcccaac 1770421 cagtaaaatc acaaccgctc aggcaacgat tatcatcatt aattatatgc ttgctgccgg 1770481 agttcttacg ctccctcgga cagtaacaga acaaacacaa tctcctgatg gatggatttc 1770541 agttttatta ggcggggtcc tagcggtaat agccgggatg attatagcta aattaagcca 1770601 gcagtatcct aaggagacct tttatgaata ctcccgacat attgtaggaa aatggctcgg 1770661 gcatctgatc agtattgttt ttattactta ttttctggca ctcggtgcat ttgaagtcag 1770721 agtcatgtcc gaaatcgtgg atttttttct cctcgaaggg acaccttctt gggccatcat 1770781 tatgacagtt ctttggattg ggctttattc aattacacaa ggcctagatc cgattgcacg 1770841 gctttttgaa atgatttttc cgattacggt catcatcttt ttaacgatag ccctcatgag 1770901 tttaggcata tttgagatca acaatttgcg ccctgtatta ggtgatggaa tcatgccggt 1770961 tcttagaggt gtaaagacaa cgaacctttc atttacatgt tcagaaatta tgttcatttt 1771021 agtagcattt atgaaaaagc cgaaaaatgc ggtgaaagca gttgtgatcg ggacaggcgt 1771081 tgtgaccagt ttttatatga ttacgatgat tatggtcatc ggtgcactat cagttgaggg 1771141 agttgtgacg agaacatggc cggggcttga cctgatgaga agttttgaaa tacctggttt 1771201 aatatttgaa cggtttgaat catttctgct tgtgatttgg attatgcagc tttttgccac 1771261 gtttattatc actttttatg cagcttccct gggagtctca caagttttta aaaagaaacc 1771321 cctttcatgt atgtttgggc tgcttcctgt tatatatatc ctctcttgca tgccgaaaaa 1771381 tgaaaatgac gtctttatat tgggcgatac ggtcagtcat atcgctttgt atatatttgg 1771441 cgctttgccg attttgctgt tagtcatttc gaaatggagg aaaagaggtg aaaagtaaac 1771501 taaaacgtca attgcctgct atggtcatag tatgtctgct gatgatttgc gtaacaggat 1771561 gctggagcag tcgggaaata gaagatctgg gtctcacatt cgctatcgca attgataaag 1771621 gaaaagaaac gaacactgaa aaagagttaa aagaagaggg cgggagctat ccgaaaaaag 1771681 acaacattac gctgacctat caatttgtta atgaaaaagc ggcaggcgcg ggcacaagcg 1771741 ggggaggcgg tagcggacaa ggagcgcaaa aagcgtacat taatataagt gaaacagggg 1771801 attcattaca gcagatcgga agtgaggttg cattaagacg ggaccgagaa gtgtttagcc 1771861 cgcatttaaa agttgttgtc atgagtgaag atgtgctgca cacatttcct atcgacgaaa 1771921 tgctggatca attttttcgt gataatgaaa tcaggctgag ctgtcttgtt ttatctgcta 1771981 aaggggaagc aagagacgct ctccagctga aagagaacgg agaaattccg gcatttcggc 1772041 tgattggatt aggtgaaaat gaacataaag tttccagaat tcttccccct atgacactcg 1772101 cgaaactaat tggaaaactg cattctggca gcagcttttt actgcaaaat gtggttgcgg 1772161 cgaatggagc ggtcaagtat tccggagcag ctgtaatcaa cggaaaatcg aaaaaaatga 1772221 taggcacctt aaatgaatat gaaactgagg ggattacatg gattagagga gaagggaaag 1772281 gcggagttgt caaaagtcat gataaaaaga gccaacagac gttagcgtac gatatcaata 1772341 aaatcaaaag cagaattcag ccaatcgtaa aagggaaaga tatttcattc catgtcgata 1772401 ttgaatcaga aggcgatttg gttgaaaact ggaacacaaa agaggcgttg gacacccagt 1772461 ttatagatcg tctcgaaacg actattgaaa acgaggtaaa gaaaatagtt ggtcaggtat 1772521 taaaaaaaat tcagcatgat tataaagcag atgttgcggg ttttgatgaa tcttttagac 1772581 ttacatatcc tcacttatgg aaaagggtga aaaataactg ggatgacacc ttcagtaaag 1772641 ccgacatcac atacagtgtg aacgtcacaa ttactcattt cggcacggtt aaaactcagt 1772701 aatgaatccc aaggaagaga aggaaacctc tcttctcttt tttatgcatt tattaggata 1772761 aagatacttt ttttggagag atatacactt ttcaaatcga ccaatatgct aatataggaa 1772821 ttgcttgaaa tagaagggag aaggggctgt gaggcagaaa ccgatttatg tagaaatcga 1772881 aatgaaatct gatctggata cactctggga atatacacaa aacccatcac tgcataagga 1772941 atgggatctc cggttttcaa atattacgta tttgaatagt cagccatgcg aaaaacagaa 1773001 gtttctttac gaaacaaggg taggctttgg attaaaggtg tcaggtacag gagaaaccgt 1773061 cggtgttttc aacaaatgtt catctgaaag gtcttcttca ctggcttttg gctctgatca 1773121 tccattatct ctgattcggc atggaagcgg ctactggaag tatatacaga gagaaaatgg 1773181 gaaaatgacg tttttaacac agtaccaata caaaacagcc tacggactgc tgggaagatg 1773241 gattgatcgt ttattatttc ggccgctgct tggctgggcg actgcctgga gctttgatgc 1773301 attaaggctt tgggtagagc aaaataaaca tccgaagcgc ttcattcgat ctgctatcat 1773361 ctatgtgttc atgtgtctgt ttttcagcct gttttggttc tatcaaggct ttgcaggtgt 1773421 taagacaagc atattgacag gaacagcgga gataggctta gctattttgt ggctgcttcc 1773481 tttaaaaaga aaatggatca ttcatggtgt ccaggcttgt atttttgctg ggtttgcttg 1773541 tctaggttcc gaaatattca tgtgggttct attgagtgtg ttttccgctg caagcggcgc 1773601 tcttagcctg cagctcccca gtgccaggcg cacaaaacga aagagaaaga agtgacattg 1773661 tgagttcgat ttatgaaaaa tcaattatta actatcattt gctgcatccc aagctgcaga 1773721 aacggtacca attagacggg tctcatacat tcagcgggac gggaacgatg tcagaaataa 1773781 gcggaggctc ttttctggtt agaatgctgt taaagctggg tgtttttttc agatgcttct 1773841 tttcagaaag aggcaaagac attccattta caatacaaaa tagaacttgt cttttgaaat 1773901 cgcaacatac aggaatagaa tggaatcgta catttttctt taaaggcaaa aaacgtttct 1773961 ttgatgcgtt aatgatatat gacgagaaag aaaatagaat acttgatttc ttcggcaaac 1774021 ctcatctgct gctgtctgtt ttgacgttcg aggcatctct tgacggctct cttacgatca 1774081 catcgggaaa gcaatggcta ttgatatgcg gaaaaagaat cccgctgccg aaatggctga 1774141 ccggtacatc cgaagtttgc gaaacgtttg atgaaaaaaa gaattgtttc accattgaag 1774201 tgcatgtgca aaatacaatt cttggcactc ttttctttta taagggaacg tttcaggagg 1774261 aagagagaga atcatgaaac gaaatggcat agtcagtgcg ctttgtttta ttggatttct 1774321 tgcagcagaa gcaccggata tttcagtggc agaggcactc gttttgttat ccattctatt 1774381 tttcgtgccg ggaatttttc cttttgtttt tcgtcaatct ccggttcgtg ctgctcagtt 1774441 tatggaaaac gggctaatcc agtgctatcc tgtagccgca ttctttgcgg tgctggctct 1774501 agtgacggag gttgggggtt tcgcacttat ctggtggatg tacacagttt ttaatgcatt 1774561 gtatgcgatc ctccgccttt gggaaacaaa gatacataga atcgaagaga catcagtttt 1774621 gttcggtctt atttatttgg cgggaggagg attttggttt tttgcttatg ctgcccattt 1774681 gcagatcatg caatttggcc ctctcatcat tttgctgact gctgtccact ttcactattc 1774741 tgcttttctg atcccgatct tcaacggttt actcggcaga accattagaa aacatcggat 1774801 gttgtacagt tggataacat gggtgatttt gctttcgccc cttcttatcg cactgggcat 1774861 cacatattca aaaacacttg atgtcattgc ggttagcatt tatatggcgg cgatttatct 1774921 tcatgcattt ttggtgttca cggcagcttt tcgcaccaag acggggacat ttcttattcg 1774981 gctttcttcc gctgttttaa tgataacgat tgctttctcg atgatttatt catttggtgt 1775041 ctttcggcaa gaagttacat tgaccatcaa tcagatgatt tggattcacg gttttgtcaa 1775101 cgcgtttggt gttatcttgc ccgctctcat agggtggaga atagaggatg cgaaaccttt 1775161 tgatgcagac agtgtaaaga cattcagccg tatctacgga aaaagaaaga ttggagaaga 1775221 atttttagct aacattcaag ctgaaaataa cgctcggtac agcggacttg tggatgatat 1775281 gggcagcctg cgttcaaaag atttttcacc agaaaaactg gcgccgctca ttctttcgtt 1775341 ttatgaacaa accatcgaat acaatattaa agcaaaagta acatggagca cgtggtttcg 1775401 gccgcttgca attatttacg aatggttcag cagaagaatc ggccaaatac atctttcgac 1775461 gaaccctgac tggtatagga tgtacagcaa gataaaaggt gttcattcga aaaaagacgg 1775521 aagggaaaga gtacgtgcct ggattagaac aaatgaaaaa aacgaaacca tttttaccgc 1775581 tctttattca gtgtatcgtt caaatggaga ggggtatatg aatatttctt taccgcttcc 1775641 attcagcagc atgacaggta ttttaaaacc atatcatcat caggagaagc tggttttaac 1775701 aagcaggcgg agaaaaagca gagcggggga tgaggggatt tatctgcaaa caagagcggg 1775761 aacttgtccg cttcctttat ctgaaacctt tctgatagaa gctgtacatg acaacaaatt 1775821 aaccgctgtt catcatatgt ggctgtttgg aataaaattt ctaactgttc attacagcat 1775881 tacacatatt aaccagccta ttgaaagaac ctaacacaaa gaagaagctt cgtctgccag 1775941 ttgtaatgag atgaactgtt ttaaaattct gcaccgcatc aagacaggaa aggaagggtt 1776001 tatggtgttt tatatcagtt tatttctgat tctttggctg gctgctgggt ttgcagtggg 1776061 aatgaaacaa gtgtatgtcg atcagctgtt tgataaagct gtgatcgaaa gactggaaaa 1776121 agaagcgaat gatcatggac atgctgaccg gatgatcaaa cagcgcgtcc tttatattgc 1776181 agcagtgaca gtaagcgggt ttatttctgt ttattatgaa atgaaaacaa tcccgcaaag 1776241 gcgaaacata agaaaaattg aaaaaaacat catgaaatta aatcaagcaa aaaaacgaag 1776301 aatgaagaga aaataaaaag tgcacaggcc aaagggcagg tgcatttttg ttttgtatgg 1776361 aaaatggggg aggtggtgcc agcttacttt tcataaattc aaaaatgaga agaacagcgc 1776421 ccgggctaat ggtatataat attgtgaatt taacaaaaat ttaacaagga ggacgagaga 1776481 attcgtgcta aagcctcaaa gagacctaca ttctgttgat ttggacttag aggcggagta 1776541 gatgaaaccg gccaaagtat ccctgctccg ccgtttgctc cattccttga agcatgttga 1776601 ttgtaacata gccaaacgtt ttccatcaac tattaaaatt gtaaaattat tgatgatttt 1776661 tatggtgttt actccgattt cttcaattta tgctgaagat gtatatcaga attttgagga 1776721 attaaaaaac aatgaagatc cttctgatta tggcgttgtt acgaaagaaa ccggaagccc 1776781 tgttcttgtt ttagctattc acggaggagg tattgaaggc gggacaagtg aagtagcgag 1776841 agagctcagc aaagagtact cgatgtattt atttgaaggc ttaaaatcgg caggaaactc 1776901 agtcctgcac attacgagca cacactttga tgaacctcgg gcccttaaaa tgacgggaaa 1776961 tcatgaatat gtcatttcat tacacgggta cgcagaagaa gatcagcaga tcgaagtcgg 1777021 cggtacagat cgcgtaagag cggcagattt agttgagaaa ttgcagcatg ccggttttcc 1777081 tgctgtattg ctcaatatgg accatccgca tgcgggcgtt agtccgaata acattgcaaa 1777141 taaatcaaaa acaggtttaa gtattcagat agaaatgagc acagggtttc gaaagtcttt 1777201 gttcggcatc ttttctttaa aaagcagagc tgttactcaa aatgagaggt tttatgagtt 1777261 tacagaagtg atgttccgtt ttctcaaaaa tagctactga aaaataggag gcgataagac 1777321 agcctcctat tccttatgct tctctttcgt ttcgggaaac agctcgtccg cggcttccgt 1777381 ttgatactgc aacgtgttat ctctcgctga cagttcattt cggaaatttt catcaagcac 1777441 atttttcagt aaataccgat gaaaaaagta ttcaaaaaca gtaagacagg cagcggaaag 1777501 gagagccgct ccaaatggtg agaaatcgtt tcttgtttgg gttaaaacaa atacccaaag 1777561 aataacgaat gaaaggccaa agtcagccaa tgaagctgta atattgtttg ttctgggtaa 1777621 gacgagcatg tcaccagaaa gataggaaac aaaacctaag aaaagtgcaa taaacatcac 1777681 acttaaaaag gatgcgtgat agactctgtc caaaatcaca tataaaaggg cgagagtgaa 1777741 agcaatcttt gaagcaagcg caatgatatg tttcatttga ccacctaaat tgttattttt 1777801 tgaagaaaat tcttgggcgt aaacaaatga taaataatgc aattcaaaac cattcataat 1777861 ggtcatgtta ctattttaaa cagtccgttt ttgtttacac tggtattttt ttcagctgta 1777921 tgaaactttc ttatgaaaaa agtcgtatat gtggatgatc agctttcaag gggggaatga 1777981 tttgtggaga taaaaggaat caatcacttg ctattttcag tttcgcattt ggatacatcg 1778041 attgattttt atcaaaaagt gtttggtgca aagcttttgg taaagggaag aacaactgca 1778101 tattttgata tgaacggcat ctggctagcg cttaatgaag aaccagacat cccgagaaat 1778161 gacattaagc tttcttatac ccatattgct tttacaattg aagatcatga atttgaggag 1778221 atgtcagcta aattaaaaag acttcatgtc aatattctgc ctggcagaga acgagatgaa 1778281 cgcgatcgaa aatcaattta ttttaccgac cctgacggcc acaaatttga atttcatacc 1778341 ggaacccttc aagacaggct tcgatattac aaacaagaaa aaacgcatat gcacttttat 1778401 gatgaaacgg ccttttgata gcacaaccat atttcatata aggttaaatt taaagaaggg 1778461 tgttggtgga gactttatgt ttggggaagg tttctacccg acttgttcaa cgatgccata 1778521 tcttttgaac tgcacaagtg attgggtgaa ggtgaaattg aaatacacat tacattacat 1778581 tttatatgaa gaaagcgagc tgttttatca aatgttgaac taattaaact atgtactaaa 1778641 ttttcagtat atttcaattg ctttgcccct taataaatat aaaaccgcat ccttccacga 1778701 cctaaaaaat gaaacgtttt taagaagatg gcgtctaata ttctaaatgt tcatattttg 1778761 ataaaagttt cctaaaggaa agaaaatttc ttgacttcaa caatcttttg gtggataatt 1778821 atggtgtaaa catgatgttc tttttcctcc tattcgggct cgcacccaaa agtcagggcg 1778881 agcctgcttt ttttgaacaa caaaccccct ctccgtaaag gaagaggggg ttattttatg 1778941 catctgatag atcaatagat taatggacgg ttctgaacac gccaatcact ttccctagaa 1779001 tgctgacatt ctgcaaaatg ataggttcca tcgttgggtt ctcaggctgc aagcgaatgt 1779061 gggtatcctc tttatagaat cgttttacag ttgcttcatc atcttctgtc atcgcaacta 1779121 caatttcccc attgttcgct gtgttttgct gtttaacgat gacatagtcc ttatcgagaa 1779181 taccagcatc tatcatactg tctcccataa tctccagcat aaatacatgc tcgtctggag 1779241 gaaccatgcg gtcagggagc ggaaaatatt cttcaatatt ttctactgct gtaataggag 1779301 atcccgccgt gactttcccg atgaccggta cattaacgac ctggctttgc ggaatgtcta 1779361 cttcttcatc aagaatttct attgctcttg gttttgtcgg atctcgtctg atcagccctt 1779421 ttgtttccaa acgggccaaa tggccgtgga cagtagaact ggacgcaagc ccgacagcct 1779481 ctccgatctc tctcacggaa ggcggatatc cttttgattt aacctctgct ttaataaaac 1779541 ggaggatatc aagttgcctt tttgatagct tcgtcatttt tcgcacctca aaacgtcgat 1779601 tttaagaaga ttatagcatg attttcctta cagtacaaac ataggttcga aaaaacaatt 1779661 gacagaaacg tttgttcgta tatactgaaa ttataaaaat gcgaacaaac attcctgttg 1779721 gaggttatga tcatgagtaa agaatctatt atttttgtcg gtctgtttac agtgattttg 1779781 agcgcggtta tccttatgct gtcatataca agcagcggcc aagagcttaa tcagtatgtt 1779841 aaaatagaag tccagcaagg cgacacactc tggtcaattg ctgatcaggt agccgataca 1779901 aaaaagataa acaaaaatga ttttattgaa tgggtagctg ataaaaatca acttcaaacc 1779961 tctgatatcc agccgggtga tgagttagtg atcccattga aaaagaagca tcaggatgca 1780021 tatgaattag caactgtaag atagagagga aagagagata aaatgaaagc actcatttat 1780081 gcccgtgtaa gcacaaataa agaacagcag gaaacgtcat taaagcggca ggaggaggag 1780141 cttacggcca ttgcagcgga gaacggcatg gaagtggtca aagtgatttc agaaaaagcc 1780201 agcggatatg aaatggatcg ggatggtgta tttgagctgc tcgatgagat taagaacgct 1780261 gatattgatg tcattttggt tcaggatgag acaaggctcg gacggggaaa cgcaaaaatc 1780321 gcactgcttc attgtattta tagagaaggt gtgaaagtct atacaacggc tcatagaggt 1780381 gaactggagt tatcggaggc tgactcaatg gtcttggaaa tcgtcagcat tgtggaagag 1780441 tatcagcgaa agattcacaa catgaaaatc agacggggaa tgaaacgtgc agtaaaaaac 1780501 ggttttaaac cgcaaaaaaa cttaaaaaac caacatggga acagtggaaa agaaaaaata 1780561 gaggtgccaa tctcagagat cgtccgcctg agagcgaata aactgacgtt tgctgaaatc 1780621 gcggctaccc taagagggtt tggctatgat gtctctaaag caaccgttca ccggcgtttt 1780681 caggaataca tagagaatga agagactgca gagtgaatca gttgtaaaac tttttttgat 1780741 ctagtactat atagacaaaa tgcaataaag gagtttaaca tgatttcaaa cgcgaaaatt 1780801 gccagaatta atgaacttgc tgccaaagct aaagctggcg ttattacaga agaagaaaaa 1780861 gccgaacagc aaaagctccg tcaagagtac ttgaaaggtt ttcgttcttc tatgaagaac 1780921 acgttaaaaa gtgtgaaaat cattgaccca gaaggcaatg atgttacacc agaaaagcta 1780981 aaaagagaac aaagaaataa caaacttcac taatataaga ggaatacggc aatatcgtat 1781041 tcctcttttg catatactat aatcaaaact cttatgtgac aaaattcaac aagtttctct 1781101 caaatttaag ctgaaacagt tgagaaaaag tcgtcagaca tttatgatgt aagggtacaa 1781161 cacataagga aggggatttt tatggataca attgaaaaga aatcagttgc taccattcgc 1781221 acactgtcaa tagacgctat tgaaaaagca aattctggtc acccagggat gccgatggga 1781281 gccgctccaa tggcatacac gctgtggaca aaatttatga acgtaagtcc ggcaaaccct 1781341 ggctggttta accgtgaccg ttttgtttta tctgctggac acgggtcagc actattatac 1781401 agcatgcttc atttaagcgg gtttgatctt agtattgaag atcttaaggg attccgccag 1781461 tggggcagca aaacaccagg acatccggaa ttcggacata ctgccggtgt tgatgctaca 1781521 acaggtccgc ttggccaagg aattgccatg gcagtcggta tggcaattgc tgaacgccat 1781581 ttagcggaaa catacaaccg cgattcattt aacgtagtcg atcattatac atacagtatt 1781641 tgcggtgatg gtgatttaat ggaaggtatt tcttctgaag ccgcttcact cgcaggccat 1781701 cttcagcttg gccgtctgat cgtactatac gattctaatg acatctctct tgatggagac 1781761 ctcgaccgtt cattctctga aaacgtgaaa cagcgttttg aagcaatgaa ttgggaagtt 1781821 ctttatgttg aggatggaaa caatattgaa gaattaacag cggctatcga aaaagcacgc 1781881 caaaatgaaa agaaacctac attaattgaa gtgaaaacga caatcggatt cggttcacct 1781941 aaccgtgccg gtacatccgg tgttcacggt gcgccgcttg gtaaagaaga aagcaaatta 1782001 acaaaagaag cttacgcgtg gacatatgaa gaagacttct acgttccgtc agaagtttat 1782061 gagcatttcg ctgtagctgt taaagaatca ggtgagaaaa aagaacaaga atggaatgct 1782121 caattcgcta aatataaaga agtttatcct gaacttgctg aacagcttga actggcaatc 1782181 aaaggagagc ttccgaagga ctgggatcaa gaggttcctg tgtatgaaaa aggaagcagt 1782241 ttggcatccc gtgcatcttc cggtgaagtt ctcaacggac ttgcgaaaaa aattcctttc 1782301 tttgtcggag gttctgctga cctagcggga tcgaacaaaa cgactattaa aaatgccggt 1782361 gattttacag cggttgatta ctcaggcaaa aacttctggt ttggtgtacg tgaatttgcg 1782421 atgggtgcgg ccttaaacgg tatggcgctt catggcggtc ttcgtgtatt cggcggaact 1782481 ttctttgtct tctctgatta cctgcgtcct gcgattcgcc ttgcagcgtt aatgggcctt 1782541 cctgtgacat atgtcttcac acatgacagt attgcggttg gtgaagacgg tccgacgcac 1782601 gagcctgttg aacagcttgc ttcactccgt gcgatgccta acctttcttt gatccgtcca 1782661 gcagacggca atgagacagc agcagcatgg aagcttgcag tgcaaagcac tgaccaccca 1782721 acagcgctag tgcttacacg tcaaaacctt cctaccatcg atcaaacatc tgaagaagca 1782781 ttggcaggag tagaaaaagg tgcatatgtc gtttctaaat ctaaaaacga aacacctgac 1782841 gctcttctca tcgcttccgg atcagaggta ggtcttgcaa ttgaagcgca ggctgaattg 1782901 gcaaaagaaa atatcgatgt ttctgttgtc agcatgcctt caatggaccg ttttgagaaa 1782961 caatctgatg aatacaaaaa cgaagtcctt cctgcagatg tgaaaaaacg tcttgcaatt 1783021 gaaatgggct catcatttgg atggggcaaa tacacggggc ttgaaggtga cgttctcggc 1783081 atagaccgat tcggtgcatc tgctcctggt gaaaccatca ttaacgaata cggcttctca 1783141 gttccgaacg tagtgaatcg agttaaggca ttaatcaata agtaagcttt tgaaagagga 1783201 tgagtcaaat catcctcttt ttcttgttta tccgacaaaa atagtattgg ctgtttaaca 1783261 gtaatagaca attctttctt ttcttctttt gtataataga gagcaaatga aatgctgctg 1783321 gaaaagggga tgaaaagatg gaacgtcact actatacgta cctgatcaaa gaggaatttg 1783381 ccaatcacta tttcggccgg gaatcggtta tgtttgagct gtttcaagac tatcattgga 1783441 caagccttga aaagcagcag tatgaaatga cagagaaaca gattcaatat attacacaac 1783501 caatcccgat tttacatatg catcagcggt taaaaatgaa tttaaacaag acggattaca 1783561 ggcagctgga ttatatttat agaatagctt tgccgaaagc aaaaggccac gcgacgttta 1783621 tgatgaagga gcacatgata gaaattgtgg cttcgggaga ttacgaggca gaaacgatat 1783681 tctttgaagt gttaagaaaa gtaagccctt gctttttagc aatggatttc aattcgaagc 1783741 gttacggatg gctaaatccg gtgaaagaaa gaaattttgt ctaaaaccga agaaaaagag 1783801 atgtaaatgt tgtataatag cttttggttt agtacacttt aaactagaca acatgaagga 1783861 ggaaataaaa tgactttatg ggttggcatc ctagtgggcg ttgttgcatt gctcataggt 1783921 gttgcactcg ggttttttat tgctcgtaaa tatatgatga gctacctgaa aaagaatccg 1783981 cctattaatg aacaaatgtt acgcatgatg atgatgcaaa tgggaatgaa accttctcaa 1784041 aagaaaatca atcaaatgat gaaagccatg aataatcaaa cgaaataata cgtaaagatt 1784101 atgatataga gaaacatggt tataaaataa aaaaccctta tacgggtttt ttattttgca 1784161 atcattcatc acccgctact gctcgaaggc gctgcttttg atattgtatg agaagatggt 1784221 caagctcctg actgagctct atcgtaatat gagatgtcat tccgttcgcc atgacaattt 1784281 gcagcagctc tgctcttttt ttttcaattt cttttaatag atgctctcta atcacaggga 1784341 tgtatccttt catacattag atcttcaaag tgaatgttta tattatatcc atatttatac 1784401 taattttcaa atgagaagga gtataatgtc tcaatgtcaa attaaattat ataagttttt 1784461 tctgaaaata gaaatccttc aagtgaaagt gttaaaaaaa tgaaatgatt ttgtcataac 1784521 ttgaaggaat gtcaaatcat gaagggatga tgacatggga gacgtgaatt attttttgac 1784581 attcggagcg gggtttttat cctttatttc gccttgctgc ctgccgcttt acccagcttt 1784641 tttgtcatat attacagggg tcagcatgga cgatgtaaaa actgaaaagc tgctgctgca 1784701 gaaaagaagc ttgtttcata ctttgtgttt tttgcttggc ttttcagtca tttttattgc 1784761 tttaggctat ggaacatctt ttattggcag cctgtttagg gattatcacg atgcgattcg 1784821 gcaaattggc gcgttgctta ttattttgtt cggtttcatt acactcggtg tgttccggcc 1784881 tgaggctatg atgaaagagc ggagaatcca ttttaagcat aaaccaagcg ggtttttagg 1784941 gtcggtctta atcggaatgg catttgcagc tggatggaca ccatgtaccg gtccgatatt 1785001 agctgctgtt atcacacttg caggcaccaa tccgggctca gcggtgccat acatgatgtt 1785061 atatgtactc ggttttgcgg taccgtttct tttattgtct ttttttatca caaagctgaa 1785121 gtggataagg aagaaccagc ttttcattat gaaagctggt ggcgttttga tgattgtgat 1785181 tggtgtgctg ttattcttta attggatgag cctgatcatt attttgctgt cagatctttt 1785241 tggaggcttt actggttttt gacggtaaat tactttcgta ctactactaa tccttttgtt 1785301 tttggtacaa taagactatt atctgtggaa atcgattgtt ggaggggaat atgacaagag 1785361 ttttagttgt agacgacgcc aagttcatga gagtgaaaat cagagagatc ttggaagagg 1785421 caaattacat aatcgcaggc gaagcggcgg acggtgaaca agcagctgac ctgtataaaa 1785481 aactgcgccc ggaccttgtg acaatggata ttacaatgcc ggtgaaaaac ggcataaaag 1785541 cgcttcgtga tatcttaacc tttgatccta aagcgaaggt catcatgtgc accgccatgc 1785601 gccagcaaag aattgtaacg gaagcaattg agctgggggc aaaggatttt attgttaagc 1785661 cgtttgagga aacaaaagtg ctggaagctg taagccgcgt tatgggacat taaagtcatt 1785721 tcttttcaaa atggtttttt ttattgtttt ggagtatagt atatagtatc aacactccga 1785781 gaaacaaagg aatgataagt atgatgatta tagtttcatc aattattgct gtgttaatgg 1785841 ctgtagctgt gatggtggtc agaataaagt cctctgacaa gcctgtttca ccaaaaaaaa 1785901 tcattcttcc gccgattttt atgagtacgg gagcgttaat gtttttattt ccggtatttt 1785961 gggtaactgg agcagagttt ttggaagcat tcactttagg tgtgattttc tctatttttc 1786021 taatcaaaac ttctaagttc gaaattaaaa ataatgaaat ttacatgaaa cgctctaaag 1786081 catttgtttt tatattagtc ggtcttttgg tgatcagaat cgtgatgaaa tcgatcttga 1786141 gcacatcaat tgattatggt gcactgagcg gaatgttttg gattctggct ttcggtatga 1786201 ttgtgccttg gagaatcgcc atgtatttat catatcgaaa acttcataac gagctgcagt 1786261 catctaatat tcaaatgaat taaaaaacct ttcctcttgt caggaaaggt tttttatttg 1786321 agaagggtct gataaggttc caaatcgatt tttttgtccc gcagatgcct ttttaagaag 1786381 gtatggtctc ttttaggagt tgcgagaata tagcctttga tcataagttg ctgatcaatc 1786441 tttgctacct tttcttttaa tgcaagctca ccgattttgc ctgcgatttt agcttttgct 1786501 gcatctctga acagctctgg cacgggcgca gtcaattcat ctagaaactg tttgttttca 1786561 tcgttccata aatgtctgct gttttcaata tagtaatcct gccaatcaag ctctgatctg 1786621 ccgtcctctt ttggtaaacg ctttaaaaac tttcgaaaca tgaaaaaacc gccgattgat 1786681 aataagacta ccatcatgat tacccaaaac agaataaacc ataaaaacca tccttccagc 1786741 atcaatcatt cccccttatt ctaaccatat tgtatacgaa gagagattag aagaacacag 1786801 taaaaaaaga atagaaaaaa gtgatagacg tctagtcaaa agagatagta gatcatattc 1786861 tattgtatag tgaatctgct atttggccat gggagagtca ctagagggta tttgacgata 1786921 aatggacgga aaaaaagtca ctttcataat aggggatgaa agtgactttt tatgtttagc 1786981 tgagaggaaa ttgaagagaa aaagaagagc catcttctgt ttctttattg acggcgactg 1787041 tgagtatttg attttcgcat tcgacttgaa tgtttttgtc attaaaataa aaaggaagca 1787101 tcatttgttt ttcaaaagtc tgtcctgacg atttgacagt taagatgaac tcgcatccag 1787161 aaagggtaac tgttacttgt gtaggctgta aaaaagtcag atccgcttct ataatatact 1787221 gctgacttgt ttcatataaa tcaataggca atgtttcgtc gtaccaggcg aaggggtctt 1787281 caaaaaattg ccgaagccat tcatccatac tatcgaaatc attcgcatcg ttgcgttttg 1787341 aatggttcat ggaagcattc ctccacatat caaccttgct ttacatcata tgcggtggat 1787401 tataaatggg tgaacgcata aaaaaacaga cactaaggtc tgcttttctt acatatcatg 1787461 gcttgagttg tgcttttgtc ttgtatggtt tcggtttttt acttttttgc ttccgcttag 1787521 aggctcgggt tggccgggat tgtgtccttt aggggcgttt ttatgcatat ctttacttgt 1787581 attcttattg gtcataaaat gagaacctcc ttaaaagagt tcggtgttat tgattggttt 1787641 ttcttttttt gttattttgg cgttctgctt cagtcagtac aagctggtcg ttttcaatat 1787701 agccggcgcc tttgccttgg ctttttgcgt cattcattcc gttaatgacg tgattcgctt 1787761 ttcttttgac catcattatc acctcaatca taatatggct tcttttattg tgttatatga 1787821 gagagcgtaa acagtaaaaa ttaccggtac atttttctca taagtcgaac ttattgtatt 1787881 taataaaaac attgatattt acttatgtat gattttgttt taatatgaaa ttgtgagaaa 1787941 attgtgatgg aatgtaatgt tcatctgaga atgatctgat ctgaaggggg attttggaga 1788001 atggcaaacg agcaaaaaac tgcagcaaaa gacgttttcc aagcgagaaa aacgtttact 1788061 acaaatggga aaacatatca ttactactct ttaaaagcgt tagaagattc aggtatagga 1788121 aaggtttcga agcttcctta ttccatcaaa gttcttttag aatcagtatt gcgtcaagtt 1788181 gacggcttcg ttatcaaaaa agaacacgtg gaaaatttgg caaaatgggg aactgccgaa 1788241 ttaaaggata tcgacgttcc gttcaaaccg tctcgtgtta ttttacaaga cttcacaggg 1788301 gttccggcag tagtagatct ggcttcactg cgtaaagcaa tggcagctgt cggcggagat 1788361 cctgataaaa tcaaccctga aattcctgtt gatctcgtta tcgatcactc tgtacaggta 1788421 gataaagcgg gtacagaaga tgcattagca gtaaatatgg acttggaatt cgaaagaaat 1788481 gcagagcgct acaaattttt aagctgggca aagaaagcgt ttaacaatta tcaggcagta 1788541 ccgcctgcaa caggtattgt gcaccaggtc aaccttgagt tcttggcaag tgttgtccat 1788601 gccattgaag aagacggcga gcttgtaacg tatcctgata cgcttgtcgg aacagactca 1788661 cacacaacaa tgattaacgg tatcggtgtt ctcggctggg gtgtcggtgg aattgaagct 1788721 gaagcgggaa tgcttggaca gccttcttac ttcccagttc cagaggtaat cggcgcgaaa 1788781 cttgtcggca agcttccaaa cggaacaaca gctactgact tggcgttaaa agtaacacaa 1788841 gtgctgcgtg aaaaaggcgt tgtcggtaaa tttgttgaat tcttcggacc gggaattgct 1788901 gaactgccgc ttgcagatcg cgcaacaatt gcgaatatgg ctccggaata cggtgctaca 1788961 tgcggattct tcccagtaga tgaagaagcg cttaactacc tgcgcctgac tggccgtgat 1789021 cctgaacata ttgatgttgt tgaagcatac tgcagaagca atggcttgtt ctacactcca 1789081 gatgcggaag accctcaatt tactgatgtg gttgaaattg acctgtctca aattgaagca 1789141 aacttatcgg gtccaaagcg tcctcaggat ttgatcccgc tatctgctat gcaggaaacg 1789201 tttaaaaagc aattagtcag ccctgcaggt aaccaaggat tcggtttaaa tgctgaggaa 1789261 gaaaataaag aaattaagtt taaactcctt aacggcgaag aaacagttat gaaaacgggt 1789321 gcgatcgcca ttgctgcgat tacaagctgt acaaatacat caaacccata cgtgctgatc 1789381 ggcgccggac tggtagcgaa aaaagcggtt gagttagggc ttaaggtgcc taattacgtg 1789441 aaaacgtcac ttgcaccggg ttctaaagtt gttacaggat atcttgtgaa ttcaggcctt 1789501 cttccataca tgaaagagct tggctttaac ctcgttgggt acggctgtac aacatgtatc 1789561 gggaactcag gtccgctttc accggaaatc gaagaagcgg ttgcgaaaaa tgatcttctg 1789621 attacgtctg tcctttccgg aaaccgtaac tttgaaggac gtattcaccc gcttgttaaa 1789681 ggcaactatc ttgcttcacc gccgcttgtt gtggcatatg cgctggctgg aacggtaaac 1789741 attaacttaa aaaccgatcc aatcggtgtg ggcaaggatg gtcaaaacgt atactttaat 1789801 gatatttggc cgtcaatgga cgaaatcaat gcacttgtta agcaaactgt tacgccagag 1789861 ctattccgca aagagtatga aacagtattt gatgacaaca agcgctggaa cgaaattgaa 1789921 acaacagatg aagctttata taaatgggat aacgattcaa cttacatcca aaacccacca 1789981 ttctttgaag agatgtctgt tgagccaggc aaggttgagc cattaaaagg actgcgtgtt 1790041 gtcggtaaat tcggcgattc agtcacaact gaccatattt ctcctgcggg ggcaatcgga 1790101 aaagatacgc ctgccggaaa gtatttgcaa gaaaaaggtg tttcacctcg tgactttaac 1790161 tcctacggct cccgccgtgg aaaccatgaa gtcatgatga gaggaacatt tgccaacatt 1790221 cgcatcaaaa accaaatcgc accgggtaca gaaggcggat ttacgacgta ctggccgact 1790281 ggtgaagtaa catccatcta tgatgcatgc atgaaataca aagaagataa aaccggtctt 1790341 gtcgtattag caggaaaaga ctatggtatg ggatcttcac gtgactgggc tgcaaaagga 1790401 acaaaccttc tcggcatcag aacggtcatt gcagagagct tcgaaagaat tcacagaagc 1790461 aatcttgtat tcatgggtgt gctgccgctt cagtttaaac aaggtgaaaa tgcggataca 1790521 ctcggcttaa cgggtaaaga agtcatcgag gtagatgttg atgaaacagt tcgtcctcgt 1790581 gaccttgtga ctgtaagagc aatcaatgaa gacggcaatg taacaacttt tgaagcagtc 1790641 gtccgctttg atagtgaagt tgaaattgat tactaccgcc atggcggcat ccttcaaatg 1790701 gtgcttcgtg aaaaaatgaa gcagtcctga tgaatcaata ggaagagaag gcatttcgct 1790761 ttctcttctt tttatgacac aatgtgctgc ggaggtggca tatgctgaaa aaatggctcg 1790821 cagggatcct gcttatcatg ctagtcggtt atacgggatg gaatttatat caaacataca 1790881 gcaaaaaaga agtcggaatt caagaggggc aacaagcacc tgatttttct ttgaaaacgc 1790941 tatcaggaga gaaaagctct ttacaggatg caaaaggcaa aaaagtgctg ctcaattttt 1791001 gggcaacttg gtgtaagccg tgccgtcagg aaatgcctgc gatggaaaag ctgcaaaaag 1791061 agtacgccga caaacttgcg gttgttgcgg taaatttcac ttcagctgag aaaagtgaga 1791121 aacaggtccg agcgtttgct gatacttatg acttaacgtt ccccattctg attgataaaa 1791181 aagggatcaa tgctgactat aacgtgatgt catatccaac gacatatatc ttagatgaaa 1791241 aaggtgttat ccaagacata catgttggca ccatgacaaa aaaagaaatg gaacaaaaac 1791301 tggatcttga ttagattcag ttttttttat actcaaatat gcttacaagt tttcagaatt 1791361 ggaaaaaata aaagaatatg cggaggtgag aagcgtgaag aagatgagaa aacgttcttt 1791421 tcatgagctc gtcatggaaa acaaaaaaga gctgatgacc aatacagagt atttaaatca 1791481 gcttgaggaa aagcttgaac agcgatttaa gcaaaaataa cctttaattt gtattcatgt 1791541 ttacccctcc ttttgagaaa cctatctgtt gaggagggat aaacatggga aacaacaaga 1791601 aaaacggtca gcctcaatat gctccaagcc acttgggtac aaagcctgta aaatataaag 1791661 ccaataaagg ggaaaaaatg catgatactt caggacagcg gccgattatc atgcagacaa 1791721 aaggcgagta gcgaaaattc gagtttattt ctaggaggta catccgaatg acaaagaacc 1791781 aaaatcaata tcagcagcct aatcctgatg atcgttctga caatgtggaa aaattgcagg 1791841 atatggttca aaatacaatt gaaaatatag aagaagcaga agcatcaatg gagtttgctt 1791901 caggagaaga taaacagcgt atcaaagaaa aaaatgcaag gcgcgaacag agcattgaag 1791961 cgtttcgtaa tgaaatacag gacgaatctg cagcgagaca aaacggatac cgttcttaaa 1792021 aaaccaggga aacctggttt ttttctttct gatttgatta tggtaaaatg gggctaaatt 1792081 gacgttaagg gagcagagta atcttgcatg tatcaaaaaa agaaatagaa gtgcgttatg 1792141 cagaaacaga tcaaatgggg attgtctatc acgcaaatta tcttgtgtgg atggaggtcg 1792201 gcagaacggc cttgattaag gacttaggct ttttatatag tgatatggaa aaaaaaggcg 1792261 ttctgtcccc agtcgttgat atcaatattt cctataaaaa gccgcttcat tacggagaaa 1792321 ccgcggttgt acatacatgg atagaggact ataacggatt taaaaccgtc tatggttacc 1792381 acatttataa tccggccggt gagctttcca tcaaagccac ctcatctcat atttgtgtgg 1792441 ataaagaaag ctttaagcca attcaattcc gcaaagcttt tcctgattgg cacacagcat 1792501 atgaaaaggc caaaaaatag ggaagtgaac gggatatggc gtttggtgtg aaacgggagg 1792561 aacttaaccg gtggaaacaa gcagtgaaaa gaggagaaat cgcattttta acacattact 1792621 ggctggatga ccgatttcca gaagcaaaga ccgtgacaaa agccggctgt gcagacattg 1792681 ataagctggt tcagtgggga gcggcgtacg ggttaaaaaa agaatggatc cataagaaaa 1792741 gtgaatttcc ccactttgat ctgctggggg aaacacaaaa atatattttg gaacaagaaa 1792801 acctaaccga tcatcttata cgatttcatt tgtaaaaaaa gaacgcacat gaagtgcgtt 1792861 cttttttatt ggtattcaaa aaccggttca tcagcgtctt ctgaatagct gacgagaagg 1792921 tcgtggttat caaagtacca taaatcactt tcttcaataa agaaggtaat gccatcagct 1792981 tctgcagtga ctccagcctc ttgtggggca tctttcgcta caccgagaga aaaacccttt 1793041 tgaacgttgc tgcagcctcc atagcggacg aaaaagcgaa cctggtctcc gctttccaaa 1793101 tcgagttctt ctttatacca gttcaatgcg tcttcgttaa ttgtcatatt cataacagaa 1793161 cacccctttg ttcttcattt gaattttctc tattataaac gtattaggct attctgtgtc 1793221 aaaagagaag ttttttaagc ttataaccat tttactttag gttctgtttt attgataatt 1793281 cgtttaatgt tcgctcggtg tctgtatatc acaaaaatag tgagcagggt aacgacaatc 1793341 aataaatacg tatcatggac aaagaaacta tatataacag tatagatccc tgttaacatc 1793401 gatgagagag aaacaaattt agtcaagtat aaaaagatga agaataccgc aaccatcgtg 1793461 ataaataaca ggggtgcgta aaatagcaaa acgcctcctg atgtcgccac ggctttaccg 1793521 cctttaaatt tggcgaagat gggaaacacg tggcctaaaa ccgcaaagac tcctgcaaga 1793581 agcgggtgaa tatcaacatg catgagaaaa ggcaatgcag ttgccagtgt ccctttcaaa 1793641 atatctccgg ctatgacgac cgaaccagct tttacaccca atgtacggaa tgcattggta 1793701 gcgcctaagt tgccgcttcc gtgctcccga atatcaattc ctttggcaag cttgcccaca 1793761 attaagccag atggaatgct gcctatcaag taggccaaaa taatcaataa agcaattaac 1793821 atctacattt ctcctttttc aaattccctt ctttttattt taacatgaga tgtcatgatc 1793881 tgatgataag tttttttgta aagtttgctt acaaatcaaa tcaaacatgc atcatatttt 1793941 gatttctcct gttttgatcg tgtaaaataa gtgaaaaagg agtgacacac gatgcaaaac 1794001 ccttctaaag cggaaattaa agagattctt caaagaagca aacgtatagc ggtagtaggg 1794061 ctttcagacc gtccggatag aacgtcacat atggtttcaa aagcaatgca ggacgcgggt 1794121 tatgaaatta tccctgtgaa ccctacaatt gatgaggcgc taggtgtcaa agccgtttca 1794181 tctttaaaag agatagacgg tccgattgac atcgtaaatg tattccggcg ctcagaacag 1794241 cttcctggag tggcggaaga gtttttagag acagatgcgc cagtattttg ggcacagcaa 1794301 gggctagtta atgaggaagc ataccagatg ctaaaagaaa aaggcagaac ggttatcatg 1794361 gatctgtgca taaaagtggc acacgctgta acaaaatagg tgcagaactg caaaaatcct 1794421 tgtaaattca aggatttttg ctttttaatt ttaagatatt gtttgcgtat tacggtgaaa 1794481 cagatacaat aaagcttgaa cagctttttt tgaatacctt gtccagctgg gtttcggccg 1794541 ttcgatttgc gaaggtctgc tgctttatat ataataaaca aacatacgtt ctcatagtgt 1794601 aaaaacagca ctagccgatg ttttgagaag aactgattcg ttagctctat gttgcgattg 1794661 caaacatatt ggttataatg aggagtccaa ggcagtactg gctcgaggcg aggtttataa 1794721 aaaatatctt atatacaaat gatgtgtaac actgaaaaga gaaagacaat gttagttttt 1794781 gaaaggggtt tgtacgtttg gctagaaaac agcaatttga ttacaacgaa gatgccatac 1794841 aggtgctcga aggccttgag gctgtcagga aaaggccggg tatgtatatt ggctctactg 1794901 acgcgcgggg tttgcaccac ttggtttatg aaattgtaga taactctgtc gacgaggtgc 1794961 ttgccggcca tggagatcac ataatcgtca aaatacataa agacaatagt atttctgtac 1795021 aggatagagg ccgcggcatg ccgaccggaa tgcataagct cggcaaacca acccctgaag 1795081 tgattttaac ggtgcttcat gccggaggga aattcggcca aggcggctat aagacaagcg 1795141 gcgggctcca cggagttggt gcatcagtcg tgaatgcttt atctgaatgg ctgacggtta 1795201 ccattgagcg ggacggtttt gtctatcagc agcgatttga aaatggagga aaaccggtta 1795261 catctctcga aaagatcggc aaaacaaaaa agacgggaac tcttacacac tttaagccag 1795321 atccaacgat gttcagcaca accacttata attttgaaac gctctctgag cgcttaagag 1795381 agtctgcgtt tttgttaaaa ggactgaaaa ttgagctgat tgatgaacgc aatgaccagc 1795441 gtgaggtctt ttattatgaa aacggcatag aagcgtttgt tgcttactta aatgaagaaa 1795501 aagacgtctt gtctgaagtg gtctcgtttg agggtgagca tcattctata gaagtggact 1795561 ttgcgttcca gtttaacgat ggttattctg aaaatatttt gtcgtttgtc aacaatgtca 1795621 gaacaaaaga cggcgggacg catgagtcag gtgcaaaaac tgcgatgacg cgtgctttta 1795681 atgaatatgc gcgaaaagtg gctttgctga aagaaaagga taagaacctt gaaggcaccg 1795741 atataaggga agggctttca gccattattt ctgtccgcat tcctgaggag cttcttcaat 1795801 ttgagggaca aacaaaagga aagctcggta ccagtgaagc aagatcagcg gtggatgcga 1795861 ttgtttcaga gcagcttgct tactttttag aggaaaatcg ggacaccgca acgcttcttg 1795921 tcaaaaaagc aatcaaggcg agccaggcgc gcgaagcggc acgcaaagcc cgtgaagaag 1795981 caagaagcgg caaaaaacga aaaaaatcag aagcgacttt aagcggaaag ctgacgcctg 1796041 cgggttcaag aaacccggca aaaaatgaat tgtatctcgt tgagggagat tcagcaggcg 1796101 ggtcagccaa gcagggacga gaccgcagat tccaggcggt tctgccttta cgcggtaaag 1796161 tcattaatac agaaaaagct aagcttgctg atatctttaa aaatgaagag atcaatacga 1796221 tcattcatgc gatcggcggg ggagtcgggg cagatttctc aatcgatgac atcaactacg 1796281 acaaaatcat cattatgacc gatgccgata ctgacggcgc ccatattcaa gtgctgcttc 1796341 ttaccttttt ctatcgctat atgaaaccgc tcattgagca tggcaaggtg ttcattgcgc 1796401 tgccaccttt atataaggtc agtaaaggaa gcgggaaaaa ggaaatcatt gaatatgcat 1796461 ggtctgatga agagatgggg gatgtcctga aaaaagtcgg caaaggctat accattcaac 1796521 gatataaggg tcttggagag atgaacgcag accagctgtg ggaaacgacg atgaatccgg 1796581 agtcccgcac acttgttagg gtcaaaattg acgatgcggc acgtgtagag agacgtgtga 1796641 cgacgttaat gggagacaaa gtagagccgc gcagaaagtg gattgagaaa aacgtcgctt 1796701 tcggcttaga tgaagaaagc aatattttag aaaatgaaaa cttatcggtc gctgaggagg 1796761 tttaatgatt gtcacagcca gaattatttc atgatttacc attagaagag gtgatcggcg 1796821 accgttttgg acgctacagt aaatatatta ttcaagacag ggcgctgccc gatgcgagag 1796881 acggattaaa gccggtacag cgcagaattc tgtatgcaat gcatacagat ggaaacacgt 1796941 ttgataaaaa cttcagaaaa gcggccaaaa cggtcggtaa cgtcatcggt aactatcatc 1797001 cgcacggtga cagctcggtt tatgaagcaa tggtgcggat gagccaggat tggaaagttc 1797061 gtaatgtgtt aatcgaaatg catggaaaca atggaagcat cgacggagat cccccggcag 1797121 ccatgcgtta tacagaggca cgattatctc cgatagcatc tgagcttctt cgggatattg 1797181 acaaaaacac ggttgaattt gtgccgaact tcgatgatac aagcaaggag cctgtcgtac 1797241 tcccggcgat gtttcctaac ctattggtca acggatctac cgggatttca gcaggatacg 1797301 cgaccgacat tccccctcat catctgggag aagtcattga tgctgtcatt aagcgtattc 1797361 aaatgccttc ttgctctgtt gacgaactca tggaagttat taaagggcct gattttccga 1797421 caggcggtat tattcagggc gttgacggga taagaaaagc ttacgaaacc ggaaaaggaa 1797481 aaatcattat ccgcggaaag gctgaaattg aaacaatcag aggcggacga gaacaaattg 1797541 tcattactga aattccattt gaagtaaata aagcaaacct tgtaaaaaaa atggacgagt 1797601 tccgtattga taaaaaggtt gaaggcatct cagaggttcg tgatgaaacg gatcgaacag 1797661 ggctgagagt ggtcattgaa ctgaaaaaag aagctgatgc caaaggcatt ttgaatttct 1797721 tatataaaaa tactgatttg cagatcacat ataacttcaa tatggtggct atccataacc 1797781 gccgtccgat gctgatgagc ctgccgtcta ttttggatgc atatatcgga caccaaaagg 1797841 aagttgtcac aaaccggtcc gtttacgagc ttcaaaaagc aaaagacaga catcatatcg 1797901 tagaagggct catgaaagct ttgtctattt tggatgaagt gattgcaaca atccgttctt 1797961 ctagcgataa acgtgacgct aaaaacaatt tgatcgcgaa atatgaattt acagagcctc 1798021 aggctgaagc catcgtgtca ttgcagctat atcgtttaac caataccgat atcacagcgc 1798081 ttaaggaaga ggcagaagag ctcggtaaaa aaattgaaga gctcgaatct attctgagca 1798141 atgataaaaa actgctaaaa gtgattacaa acagcttaaa agcactgaaa aagaaatatg 1798201 cagatacgag acgctccgtg attgaagaaa aaattgaaga aattaaaatc aatctcgaag 1798261 tcatggttgc atctgaggat gtatatgtaa ccgttacgaa ggatggttac ctaaaacgga 1798321 cgagccagcg ctcatttgcc gcttccaacg gtcaggactt cggaatgaaa gatacggaca 1798381 ggatgctgca tcagtttgaa atgaatacga cagacgtgct gctgctcttt acgaacaaag 1798441 gaagctacat ctattgtcct gttcaccagc tgcctgatat cagatggaag gacatgggcc 1798501 agcatttttc aaatctaatc actattgacc gtgatgaaac gattgtaaag gctataccga 1798561 taaaagaatt tgatccgtcg gcatatcttc tattctttac gaaaaacggt atggtgaaaa 1798621 agacagagct cactcattat aaagcacagc gttattctaa ggcacttgta gccttaaatc 1798681 tgaagggtga agatgaactg attgatgtac atgtaacaaa tggggaaagc cagatcttta 1798741 tggccactca cttagggtat ggtctatggt ttggagaaga cgaagtgaat gtagttggcg 1798801 cgcgtgcggc aggtgtcaaa gggattaact taaaagagga tgactttgtt gtctccggtg 1798861 agattcttca gcaatctgat tcaattgtct tgttcacaca gcggggagcg gttaaacgca 1798921 tgagtctttc tgagttcgag aagacatccc gtgcaaaacg cggtgtcgta atgctaaggg 1798981 aactgaaaaa gaatcctcac cgtgttgtag cactgttcgc ttgcggtctt gaacagcgac 1799041 taatggcaga aacagaaaaa ggcgacagaa aagaactgca gacaaaagag ttgcggacaa 1799101 acgacagata cagcaatggc tctttctttt ttgatgaaga ggaatcaggc aaggttacag 1799161 ctgtttggcg ccttcataca gaacaataat aaaaaacccg ctcatactat atgagcgggt 1799221 ttcgtttgtt ttttatcagc tttcatggtt ggtgaataga tctgttacag catgaatgac 1799281 ttcaatcccc tgccatacaa ataaattcag cgctgtgaaa gaaaataagc ctaaaatcac 1799341 cattcttaag ataaacaaca tgtttaacag cctcctcata ttttcgttac ataatcgggt 1799401 gatgttgaac atgaagtttg ccgaaataag acgattgata aaatttggcc agtataaagc 1799461 tttttttccg ctgacgtctg cgggagtatc ccgtactttt gctttcagcg gtcagcagca 1799521 gaacagccat tgcccataaa gcggtcagcg taaatgcccc tgtgatggat ttcttctcat 1799581 catcagcatt ttggccggct ttcatctcat gcatttcctg ctggtcggct acggctttat 1799641 aatgatggcc gatatcaaag gcgtggggaa ttgagaacaa atgaaaactg gcaatcgcca 1799701 agaataagat ggatgctttc aatatcgtta cttttttcaa atgatctccc cctcctttaa 1799761 tattactgaa tatttttata ataatacccc aatccatcct aaaagtaaac ctgatttatt 1799821 aaatttaaaa ataaatttaa ctttgttaag tatatatctt tttgcttatt tttgaaagag 1799881 aaaacttctt ttattagcgt atgtataccc ggtttatggt gtgaataaaa acatatttta 1799941 aatgatatgt tgtttaggat ttattacttt atttatgtgt aaatcaaaga gaaaggcaag 1800001 agaatgggaa gaaatgatta cattgttaat agggtactct ttttttaaag ccagtttgca 1800061 aggaatgttt ttattcgtag gaaaataata gagaaggggt cgacagagta acatctggct 1800121 atgacaatat tcttctcgaa aaaacttcct aattcgtcat attgtgatat aataaaactc 1800181 gttatgttaa aaaatctaac atcaaaatcg aattcgtatt gaattgatga aaacgggagg 1800241 taaatatgga gtcttttttc aatagtttga ttaatattcc aagtgatttc atctggaaat 1800301 acctatttta tattttaata gggcttggat tattttttac catacgtttt ggttttatcc 1800361 aattccgtta ttttattgaa atgttcagaa tagtagggga gaagccggaa ggaaataaag 1800421 gtgtttcatc tatgcaggca ttctttattt cggccgcatc ccgagtcggc acagggaatt 1800481 tgactggtgt agccttagca attgcgacag gcggaccagg cgctgtattt tggatgtggg 1800541 tagtggctgc agtaggcatg gcttcaagct ttgtcgaaag tacattagca cagctttata 1800601 aggtaagaga cggggaggat ttccgcggag ggccggccta ctatattcaa aagggtcttg 1800661 gtgccagatg gcttggcatc gtttttgcaa tcttaattac cgtctcattc ggcttgattt 1800721 ttaacgctgt tcaaacaaat acaattgctg gagcattgga tggcgcattc catgtaaata 1800781 aaatagttgt agccatagtt ctggcggttt taactgcgtt tatcattttc ggcggtttaa 1800841 aacgtgttgt cgctgtttca cagctaattg tgccggttat ggcaggcatt tatattctta 1800901 tcgctttatt tgttgtcatc acgaatatta cggctttccc tggcgttatc gctacaattg 1800961 ttaaaaatgc tttaggtttt gaacaagtcg tcggcggcgg aataggcggc atcatcgtta 1801021 tcggtgcgca acgcggactt ttttcaaacg aagcaggaat ggggagcgca ccaaacgcgg 1801081 ctgcgacggc tcatgtatcc catccggcaa agcaaggctt tattcaaaca ttaggcgtat 1801141 ttttcgatac atttatcata tgtacgtcca cagcatttat tattttgctg tacagtgtaa 1801201 cgccaaaagg cgacggcatc caagtcacac aggctgctct taaccatcac attggaggct 1801261 gggcgccgac tttcatcgca gtcgcaatgt tcttgtttgc attcagttca gttgtcggca 1801321 actattatta tggcgagaca aacattgaat ttattaaaac aagcaaaaca tggctgaaca 1801381 tttaccgtat cgctgttatt gctatggttg tgtatggatc tttatcaggc ttccaaatcg 1801441 tttgggatat ggcggacctc tttatgggta tcatggcgct gatcaactta attgtgattg 1801501 cgctgctgtc aaacgttgct tacaaagtgt ataaagatta cgcgaaacag cgtaagcaag 1801561 gacttgatcc tgtgtttaaa gcgaaaaaca tcccagggct gaaaaacgct gaaacatggg 1801621 aagatgagaa acaagaagca taatataaat ataaaacaaa gctgcattca atagttgaat 1801681 gcagcttttt cattattgga aataaattta atttttcgac tcgaatgaaa aatgacgtgt 1801741 aaagtcccaa ttcagtccag ttttctttgt tctatatgtg tcatgtgtgt cttattcatt 1801801 ggaggtagag caaattgaca ggcttttaaa cctccccaaa acaagaaatt aggttgatag 1801861 acaatcatga gaaagatttt tacaatgagt tcgtgctcat aagaagtgta gagccaaaat 1801921 gatgcgaagg aggaaaagat cagatatgaa acggtcaatc tctattttta ttacgtgttt 1801981 attgattacg ttattgacaa tgggcggcat gatagcttcg ccggcatcag cagcagggac 1802041 aaaaacgcca gtagccaaga atggccagct tagcataaaa ggtacacagc tcgttaaccg 1802101 agacggtaaa gcggtacagc tgaaggggat cagttcacac ggattgcaat ggtatggaga 1802161 atatgtcaat aaagacagct taaaatggct gagagatgat tggggtatca ccgttttccg 1802221 tgcagcgatg tatacggcag atggcggtta tattgacaac ccgtccgtga aaaataaagt 1802281 aaaagaagcg gttgaagcgg caaaagagct tgggatatat gtcatcattg actggcatat 1802341 cttaaatgac ggtaatccaa accaaaataa agagaaggca aaagaattct tcaaggaaat 1802401 gtcaagcctt tacggaaaca cgccaaacgt catttatgaa attgcaaacg aaccaaacgg 1802461 tgatgtgaac tggaagcgtg atattaaacc atatgcggaa gaagtgattt cagttatccg 1802521 caaaaatgat ccagacaaca tcatcattgt cggaaccggt acatggagcc aggatgtgaa 1802581 tgatgctgcc gatgaccagc taaaagatgc aaacgttatg tacgcacttc atttttatgc 1802641 cggcacacac ggccaatttt tacgggataa agcaaactat gcactcagca aaggagcacc 1802701 tatttttgtg acagagtggg gaacaagcga cgcgtctggc aatggcggtg tattccttga 1802761 tcaatcgagg gaatggctga aatatctcga cagcaagacc attagctggg tgaactggaa 1802821 tctttctgat aagcaggaat catcctcagc tttaaagccg ggggcatcta aaacaggcgg 1802881 ctggcggttg tcagatttat ctgcttcagg aacattcgtt agagaaaaca ttctcggcac 1802941 caaagattcg acgaaggaca ttcctgaaac gccatcaaaa gataaaccca cacaggaaaa 1803001 tggtatttct gtacagtaca gagcagggga tgggagtatg aacagcaacc aaatccgtcc 1803061 gcagcttcaa ataaaaaata acggcaatac cacggttgat ttaaaagatg tcactgcccg 1803121 ttactggtat aaagcgaaaa acaaaggcca aaactttgac tgtgactacg cgcagattgg 1803181 atgcggcaat gtgacacaca agtttgtgac gttgcataaa ccaaagcaag gtgcagatac 1803241 ctatctggaa cttggattta aaaacggaac gttggcaccg ggagcaagca cagggaatat 1803301 tcagctccgt cttcacaatg atgactggag caattatgca caaagcggcg attattcctt 1803361 tttcaaatca aatacgttta aaacaacgaa aaaaatcaca ttatatgatc aaggaaaact 1803421 gatttgggga acagaaccaa attagttaag cttttttttg gcggacatca gtaacgatgt 1803481 ccgtttttat catctaatag gaggtttgcg ttgtggatga aatactgaaa cagtatatgg 1803541 tgctgtataa aaaaatgagt aatatgataa atggtcccga ctatccaggt aaggaaaaag 1803601 acatccagca tcaaaaagat cagatcgaag tttacgaaaa acagctgcag caaggatttt 1803661 ctacagatta tgactatgat gtgtttgctg attctgttat caaatgcgca tatggcgata 1803721 tgacgctgga agatttagaa gccgtttatt atggattgac aacaccattt ttttgatttg 1803781 tcattcagca gtaaaatttc aatttctgtc tcactaactt aagtatactt tgatattgag 1803841 acagaaattt atttattttg tttacttcct agaatatata ttatgtaaac tagaaaagat 1803901 gaagaataaa gctttgctgt ttttatgtac atcctttctt cttcctgtaa ttcagcaaca 1803961 aaataaaaaa gcgatttccc aatcggaaaa tcgccaattc agacactcta ttatttatgt 1804021 gtgtctttgt gctcttaacg atttacaaca aatgttgtca cgctttgagc tggaagatga 1804081 gcccaaaaat gattgcctga tacagtgaga ttcgttccag gttgtagatt gctgctgctg 1804141 ctcgtgatcc atctagatac gtttgaagca gatccattct gcaaaacaaa gttttggttg 1804201 actcctgtgt tgcttttatt gatggcaaca ataacgacct tgttgtcacc tttataggct 1804261 gacacgtaaa cgttcgcatt agggtttttc gttgcatcaa tccttacata gccgggacgc 1804321 acaaactttg agaaatgagc catattgtag ccgcgtttgc tgatcgtacc atcttctttc 1804381 ataggtccat atgatcttcg gatgtaccac catacataag cttgaaagtc cccctctacc 1804441 atcgcattgt gaatatgctg tgaaacatcc aatgcctcag gccatcgatc cgccgagttg 1804501 gtatcactgt ttggatagta tacttccgtc atccaaaggt ccttccccgc tcctttttgt 1804561 ttgaaaagag gataagggaa ttggctgacc tgggtgccgt acaggtgagt tccgagaata 1804621 tccatattgg caagagcctg cggatcgttc aagatcgggt ccgacaaatt cttcaagtat 1804681 tgaaatgact caggcgcaat gacgcgggca ttgatcgagc cggcgttttc tctcataaag 1804741 cgaagtattt cttgcggcgt ccaccacgtc cactcgtgag cgtaatcagg ctcgttttgg 1804801 accgaaatcg cgtaaagatt cacaccatta ttcttcatga aggtaacaaa atcgttaaga 1804861 tgctgcgcgt atgctgcgta cttgttgtat ttcagccgtt tagccgatgt gtcaccattc 1804921 cgattaaagg tctcaaccat atcacttgga ggattccaag gagaagcaaa aacgattgct 1804981 ccgtgtttga ccgcactctt tgcagtctcc acctctttat accaattatt tcgattttca 1805041 tctacatgaa ttcttaagat tgaaaatcct aactggttct gtccattgcc aaaagcagtt 1805101 tctctttgag ctgctgtaag atccccagcc caagccggat gattcatccc tccaaaaccg 1805161 cgaatcactt gtttctctgc agatacatta actgttacat cacttgctgc caaaacttca 1805221 gtagcgcctg gccctaacat gactgacagc atagtgaaac atactaatag tacacaaatt 1805281 gtttttttta tgcgtggaat catttattcc tctccttcgt catgtgtctt ttacggtatt 1805341 aaaaaatctg catggcatat ccataatggc gggctgttcc ggtgctggcc cgtacttcac 1805401 ccgcctcgtt tttaagcggt cccattacga gtactatctt tgcgtaaact gccagtaatc 1805461 aaaattaaac aagtttcctg tacctgttcc ggtaaataca aagaatactt tgtgcacacc 1805521 ggttgccccg cttaccgcag tttctatttc cctccacgtt tgcgctccgc ctgttgaagg 1805581 cacattcaga gttccaacaa gcttaccgtc tgcactgtcg aggcgcactt ctattttccc 1805641 gcctaaagtg gatgctacat ttgctttaaa tgacctggca ccgcccgctc cgaagtctgc 1805701 atttcctaca gcaatccagt ctccattttg aatgcttgtt acatgctgat tatttactgg 1805761 cccgccgggt gctgtggact tctctgtcaa aatgcgtcca ttccaagcaa acgtttcagc 1805821 ttctacccgg ttatatgggt ttaaattgga aatttgtgtt acacctgcat aatttgccgc 1805881 tacctcttga atagatccat ctgcattatg caccagctta ttaatatggg gagagcggta 1805941 tcctttgccg gccccgaaca gagcggaact gacagtttgc gcatggtaca ccacatacca 1806001 ctcgttttta aaattgaaaa cagcatgatg gttgtttccg ccacctccga aaaatgcacc 1806061 cggatttttc aggaagtgcc ctctatatgt aaagggaccc atgggacttg aactggtcat 1806121 gtagccgatc tcacccgggg gtttatcggc cgggtgcgtg ccgccgaaat tgatgcaata 1806181 ggagtaataa tatgttccgt tatacttgtg caatcccgaa tcttcaaaca tgaaaggcgc 1806241 atcaattgta gatgcacttc caacaacact cgtcatatca ggccccaatt ttatgactct 1806301 agccgtttta ggattggccc attgtccctg cgttggattt gaaacgccag gaacgcctcc 1806361 gccggcatac aggtaaccgg ttccgtcgtc atctacaaat actgccggat caaaaagcca 1806421 tacaacacca gacattcctg gcgtacttgg cgttacgagc ggttttccga ttgggtcggt 1806481 ccatggacca atcgggctgt ctgcggtgag aaccccgata cctccgccgc tgtttgcgaa 1806541 ataaaggaag aatttatcct tgccattaat ttttttaact gcgattgacg gtgcccatga 1806601 cgcacctgcc cattttgcaa ttccacggcc tccattagct ccattggcac ctgctaccgg 1806661 aatggctccg tggtctgtcc agttcaccat atccgctgaa gatatgacga atactctatt 1806721 caaattggca aatgaattat ctttaattgt tccgttgcta ttatattcat agtcatcact 1806781 tgacatatag atgtagactc ttccgttata ggtcagcgca accggatccg ctcccaaatg 1806841 atggtcgata agcggatttg aattccctat atgttttgca attgtagtac tagtggcagc 1806901 atacgcagac ttcccagata agcagctcaa taataaaact agaatccata aacatacgct 1806961 acactttttc ctcatcactt cacatcctcc tttttcctta aaatggggga ttttcttttg 1807021 gaatttgata acaacaggtc acgaagattg cacgcataaa gtagccggaa gctgtttagc 1807081 aatgttccca gttgttctga aagctcatct tcatgtgtct ccattctctc ttttcttcga 1807141 ggagatcgca ccactccttc aaaattgttc aaaaaaactt ccccattcct agcgaccatt 1807201 gtccagaaaa taaaaagaca ggattgttca tggcctccca ctaatcacat tgaacggaga 1807261 ttacatcatt atccaagata tccctttatc taacatccta catcattaaa aaaattgtgt 1807321 atagaaactt ttggaggagt tagtgttcga ttctacaaag gaactggata catttattca 1807381 ttgataagat ggggctaaca ctccgtttat atttgtatgt tttcagacac aaaaaacagc 1807441 cgttcaatgc ggctgttttt ttcaagagta taagactatt gagcggtata cccgcttttt 1807501 catgttttgt tcatatttta ttaattgttt attcaacact gtccgctata gtaatccata 1807561 tcaacaaata tgactgccac tcgcatcttt tatgaaggga ggttcgttac gctgaaagaa 1807621 aaaataaaga cattaggccg tttttgcacc gtaggcgtcg gcaatacgct gatagatttt 1807681 ggtgtcttct ttcttcttac cgcttgtcat gtctcttatc tgccggcgca gatctgctcc 1807741 tatactgcag gtatcgtcaa cagctatgtg tggaaccgga attggacgtt ttgtgtgaaa 1807801 cgtaaggctg acgggaaaga gatcgtgcgt tttctcatga ttaatattgc cgcgtcaggg 1807861 atcacctttt tgctgcttta tttgtttcaa aattgcggct gctcgctttt ggtgagtaag 1807921 ctcgccgcca ctatcggcgg aatgatgatg aattttatcg gaaaccgaat ctgggtattt 1807981 ggagattcgc tgaaaaacat acaggatcag gagtgaagat gaatgagaaa aaaagtgaga 1808041 aaagcggtta tacccgcagc gggtttagga acgagatttc tgccggcgac aaaggcgcag 1808101 cctaaagaaa tgcttccaat cgtcgacaaa ccagcaatcc aatatattgt agaagaggcc 1808161 gcagagtcag gaattgaaga tatactgatt attacaggga gaaacaaacg ctcgattgaa 1808221 gatcattttg atcggtcggc ggaattggaa ttcaatctcc gggaaaaagg caagacggag 1808281 acacttaagg aaatgcagca gattgccgat ttggccaaca ttcattacat ccgccagaaa 1808341 gaaccgctcg gattaggcca tgcggtgctg tgtgcggagc attttatcgg agatgagcct 1808401 tttgctgttc tcttaggtga tgatattatg gtgtctgaaa caccggctct tcggcaatta 1808461 atggatgtat atgacgttta tggcacagag gttgtcggtg tacagtcagt tctccctgag 1808521 gatgtcagca aatatggtat tataaataca tcagggtctc aagggcatgt atatgaagtg 1808581 aacgatttag tggaaaagcc ttctcctgaa gaagcacctt cggaaatcgc agtaatggga 1808641 cgttatgtgc tgaattcttc gatcttctcc gttttgaaga caattggcag aggcgcgggc 1808701 aacgaaattc agctgacaga tgcgcttcgt gaggtttgcc gtaaggagcc gatccatgcc 1808761 cggctgctgg aaggaaatcg atatgacatt ggcgataagc tgggctgttt taaagcgagc 1808821 accgaaatcg gcttaatgcg tcccgaaatg agatctcagc ttttggccta tttagaagat 1808881 gtgatcaaac gggaaacgaa agaaatgctg cggtaaaaaa attgtaacca tcttgctcgt 1808941 caatcagtca tataatagtg aaaaagatta ggacaggttg tgaagaatgt gggcagtttg 1809001 ataagcgaaa ttttaacatg gctgacgaac atgggatatg cgggtattgc gattgggtta 1809061 atgattgaaa tcattccgag tgagattgta ttagcttatg gcggctatat ggtatcggag 1809121 ggcacgattg gatttattgg cgcaattatt gcgggtgtta tcgggggcac cattgcccag 1809181 atctttattt actggatcgg tcgctatggc ggcaggccat ttctggacaa atacgggaag 1809241 tatttattga ttaaaaagca tcatatcgat atgtcggaaa actggtttca gaaatacggc 1809301 gccggagttg tcttctcggc tcgttttata ccggttgtca gacatgccat atccattccg 1809361 gcaggtattg ccagaatgcc ttttctcaaa tttgtggtac tgactgtgct tgctatcatt 1809421 ccatggtcta tcctgtttgt ttatttaggc atacagctag gaagccagtg ggatgatgtt 1809481 gagaatatag caggcactta tacaacaccg attatgatat tggctgttgt cgtgatagcc 1809541 ctttattttg tgattaagaa acgtacagcc atatttaaac gatagctagc ggatatgcat 1809601 aggggtgact gacgctcccc tatgcatatt tttttacttg cgatgttgat ttgccagctt 1809661 cagattctcc gctaaaaatg cgacaaacac ttcatcccgc acgagcgatg cggcataatt 1809721 tctcttaata aaccattctg cctcttcaaa cgctgcgaat gtttcgtctt gggtttctcc 1809781 gttaatttga atattccatt cgttgtctaa agggaaaaga aaaaatctca tttgtgcgcg 1809841 attttcatat aatgatccat tcgcagatcc ctttagatta tagatgttac ggaaggcatc 1809901 cggccgtaca ggatcaatac ggaaagcttc agctacaaac aactcgtata cttcatcggt 1809961 tattgaacag ccggacgctt ttgcatgccc tccgccgcca tatcggccgg cgatttctga 1810021 cacatcgatg taatcatgaa tggtgcggag actgactcgt tttgacccca tgctcaaaat 1810081 cgcaatgtaa tcgaggtgcg ggttatcttt ccctagcctg ttccccagct ctgaatggta 1810141 cgattcagcg tgaacgatgc ctacacagtg ttcgtgaaca aaggtttgta ccatttccct 1810201 tttctttctg cggaggtagc gctcgatttt ttcgtcttct aaatcaagca gtttttcttc 1810261 aaaatcatcg aagaaaaatt cgtcatgcgt ggaaaggcgc tggatcattt ttgcttcaaa 1810321 ttcatcgatt gacagcaaaa agaaaagatc attaagccgc ttcgcctgtt tttgatcgta 1810381 ccgctcccac tcccatgtat cgtattggcg gacgagctct gtgaattgat ctaaggcgtt 1810441 tgtcggtttc atgaagccat tttcaatgag atagccatat aaaagcgatg tcgcggatgt 1810501 gagccttcca tcatcgtatt ccacctggac aaatccccat tcatgctcat tcaaatgaag 1810561 ggctgtttta tgatggtcaa tgagcttcac tttgccccct gcatgaacat actcattcaa 1810621 tctctcttcg ttttcttcat tgacggcgag atcggtgatg aataacgcgt cctgtctgtt 1810681 gctctccttc gctttttcta aaaagtactg cacctgtgcg tttaagccgt tgacagagtt 1810741 ataccggatc tctacgtctt ttccgaacgc caattttgct acgattccgc atcctactcc 1810801 gtccaagtcg ttatgtgaat ataaatgata cataatgtag gccccttttt atgataaact 1810861 gacaattgcc gctagaggtg cggcagcctt tatttactat tctaaaaaac caagcgtttt 1810921 atgcaatggt aattagttga cataatgttg ttattgtaaa tatataaagg agcgcttttt 1810981 ttgcgctcct aagttcttgc ttttacaccg gataaaccgg atgctttcga ttggtaaatg 1811041 tcatttcctt tgtcatgtat gccttgagcc gtttggccag ctcatcacgc agcgaattgg 1811101 ctgggataac agcatcaatg atcatttctg aagccagacg gtagatattg atgtcctctt 1811161 tgtattcctc ccgtttgctg ctgataaatg cggctctctc ttcttctggc agctcggcga 1811221 tttttttagc gtagacagcg tttacagcgg cctcagggcc catgacggcg atttgggcgg 1811281 ttgggagcgc tagacagcaa tccggttcaa atgccggccc tgccattgca tacaaccccg 1811341 ccccgtaagc ttttcggaca atgacagaga gttttggaac agttgcctcc gacatcgcag 1811401 aaatcatttt cgctccgtgt ctgataatcc cagcctgttc tacttttgtg ccaatcataa 1811461 aaccggggat atcggctaag aacagcaatg ggatatgaaa agcgtcacat aaggtaataa 1811521 acttagccgc tttgtctgct gaatcgtgga ataagacgcc tccttttacc ttcggctggt 1811581 ttgcaacaat gccgacaggc tgtccgtgga ttcgtgcgag gcccgtcaat aattccggtg 1811641 caaataaggc tttgatctca aaaaatgagt cttcatctat gacccgctca atgagctcat 1811701 gcatatcaaa aggtgcgttt tgattttgcg gaatgacgtc ggcaagcgga gtttcgaagt 1811761 gttttggcgg gcgtttctca tgaatgggcg ctttttcttg aaaatttgcc ggaaagtaag 1811821 acaaataagc ccgcaccagc tgtatggctt cttcttcagt ttctgcaaga atatctccgc 1811881 agccggagat tgagcaatgc atacgggcgc cacccatttc ttcgagagac actttttctc 1811941 caataaccat ttccgccatc cttggcgaac ctaaatacat ggaggcgtta ccgtctacca 1812001 taacgacgat atcacagaag gccggaatat aagcgcctcc tgccgcagat ggtccgaaaa 1812061 gcagacagat ttgcggaatg cgtcccgata atttgacttg attgtaaaaa attcttcctg 1812121 caccgcgtct ccctggaaag acattgattt ggtcggtaat tcgggcgcct gccgaatcga 1812181 ctaaataaat gagcggacag tttaattttt cggcgatttc ttgaattctg atgatttttt 1812241 caactgtttt tgctccccat gaccccgctt tcactgttga atcattcgcc atgacgcaaa 1812301 cggtttggcc gccgattttg ccgatagcgg ttacaactcc gtcagcggga agcccgtctg 1812361 acatacattc cgcaaaaaaa gcgtcttcta gctcaatgtc atcgtcaaag agaagggaaa 1812421 gccgctctct gacaaagagc ttgccttttt cccgattgct ttgatgatac ttttccgctc 1812481 cgccttttcg aatccgttca gcccgttctg ttcgttcctt ttcataatcc atcagcattg 1812541 cctccctttt atattccctt gtatacggcc cgtctttttt cttgaaaggc ctgaagccct 1812601 tctctcctgt cttttgtcgg gatggtttgt tcatacgctt tttgttcaat cgcaaggcct 1812661 gtagcaagat ctgtctccaa tcctttattg attgcaaatt tagcctgacg gacagcgatc 1812721 ggtccgttgg cagaaatggc tgcggccagt tcctctgctt ttggcataag gtcacaagga 1812781 gccgtgacat gctctacaag gccgatttct tttgcttcgt gtgcggtcac gcgtctgcct 1812841 gtataaatga attcttttgc ttttcctctg ccaatcagcc ggggcagcct ttgggtccct 1812901 ccagcgcccg ggataatagc taaccctgtt tccggaagtc ccagcacagc tgcttcagtt 1812961 gcgattcgaa ggtcgcatgc caatgccaat tctagtccgc cgcctaatgc gcttccattt 1813021 atcgcagcta tgaccggctg cggcaaggca tcaagtaaag ccgccgttct ttgaatgaga 1813081 gatacacttt ccagaacctg atcttctttc agttttatcc gttccttcag gtctgcccct 1813141 gcacaaaacg ctttttcacc ggtgcctgtg aggatgacgc aacggatgtt tgagttaaat 1813201 tcaatttcct ggataatcat ttgcaggttt ctaagcattt ccgctgaaag agcatttgct 1813261 gcctgaggcc tgtttaaggt gatcaacgcc atatgttcat ttttaacagt aaaaagaata 1813321 gaatctccca ttgtatgcgt cctccctttt atcaagatga tttaaacacc tgtaaatttc 1813381 tgctcggcag cggtttgccc attttttctt caatccattt ggccgcagat agcagttttt 1813441 ctagctttac atttgttttg atatccatct gttcaagcat gtacacgata tcctcagttg 1813501 cggcgtttcc tgatgaacct ggcgcatatg ggcatccccc aagcccgcct gccgagccgt 1813561 cgaacaccgt gatgcccatt tggagtgctg tgaccatgtt ggccagagcg gttcctctcg 1813621 tatcatgaaa atgcagggca atttgattag ccgggaatcg tgccaaaaga gcttcaagta 1813681 cagtttccac ttgggcggga ttagctgctc caatcgtatc tccaagcgac agttcagaaa 1813741 tcccaaattc aaatagagct tctgaaaggc gaatgacttg ttcaatgggg acatcttttt 1813801 cgtacggaca gccgaaaaca gtcgagaggt aggctcttgt tgtgaggttt gctttttgtg 1813861 cgtcgttgtt tacttgtttg agtatatgga gggattcaga agtggattta ttgatgtttt 1813921 ttctgttgtg cgtctcgctg gcggacataa aaacgcaagc ctcgttaatg cctccttcaa 1813981 gtgcattctc cagtcctctt tgattcggga caagtgccgc gtacgttacc cctttttctc 1814041 ggtcgatgcc ttttgctaca tcgatagcat ctcgaagcgc cggaatccat ttcgggtgaa 1814101 cgaaggatgt gatttcaata tacgacagcc ctgtccggga aagctggttg atccaggtta 1814161 ttttatcctc tgttgcgatc caaacgggct cgttttgtaa gccatcacgc gggccgactt 1814221 ctttgattgt cactttttta ggatatggca tggtcttcct ccaaattatt gagtggaatt 1814281 gctcagttcg agcagtacgt ctccttcatt tacaaagtcg ccttcctttt ttttgacttc 1814341 ttttacgatt ccgcttctat ctgcaacgat cgggatttcc attttcatcg attccaaaat 1814401 ggctacctcc tggccctttt cgatttggtc gccggctttg acgtggactt tccacaggtt 1814461 tcctgccatt tgtatgctaa ccgtcatgac aactgcctcc tttataggtg ctgtttcaaa 1814521 aagtcagtcg tgacatcccc ttctttaaat gcctttgttg ccgcagcctg tatgaggagc 1814581 ggaaggtttg ttttgattcc ctctacacga tagtcgcgaa gcgctgtctc tagtttttca 1814641 attgcttctg ttctggtttg gcctttgaca atcatcttag cgatcatcgg gtcataaaaa 1814701 ggggtaacgg tgctgtcttt tgctaccgca cattcgtgtc tgactccttt ttggtcagga 1814761 agtgaaaacg cagtgatcgt acctggtgac gggaagaagg tcttgggatc ttccgcgtat 1814821 attcgaacct ctatcgcatg cccgttccgt tggatgtctt tttgggagaa tgtgagtgta 1814881 tggcccgcag caatccgcag ctgctgctca actaagtcca ggcctgttat ttcttcagtc 1814941 acggggtgtt caacttgcag tctcgtattc atttcgagga aataaaaatt ttgtttctgg 1815001 tcaactataa attcgatggt gcctgcgttc gtatagccga ttgccttcgc tgcttttacc 1815061 gctgtttgac cgatcttcat tcttagttca tcgtctacaa atggagacgg tgcttcttca 1815121 atgacttttt ggtggcgcct ctgaacagag caatcacgtt caaacagatg tactgtatgg 1815181 ccgtgttgat cggccaaaag ctgaacctcg atgtggcgcg catgttcaat aactttttct 1815241 atatacatag acccgtcacc gaaaaaatct gctgcgcgct ttttgtttcc ctcgtacgct 1815301 ttttttaatg cttcttcatt ttcaacacgc tgcattccga tgccgcctcc gcccgctgaa 1815361 gctttcagca tgacaggata gccgatttga cttgcggtgc ggcaggctgc ctctatatct 1815421 ccgagggatt cagaaacgcc cggcaccaca gggacacctg cagcctccat tgcttttcgc 1815481 gcttcaattt tgctgcccat ctttgcgatg atatcagggg aaggtccgat aaacacgatg 1815541 ttttcttgct tgcagcgttc agcgaaccgg ctgttttctg ataacaatcc atatcccggg 1815601 tggatcgcgt cggcttttgc ttttttcgcc gtctttatga ttctctctat atttaaataa 1815661 ctttcactga ctctcgattc cccgatcaaa tatgcctctg tagcggcttt tgtatggggc 1815721 gcgtccttgt ctgcttctga ataaacagcg accgttttaa tgccgagacg gctgcatgtt 1815781 cggataattc tcattgcaat ttcaccgcgg ttggcgatca gtacttttgt aaacatgatt 1815841 tcacctcatt gacttgatga taagttgaac atttcaatcg ttttttctcg cagtttatat 1815901 ttttgaattt tgcctgaggc cgtcatcgga tagtcatccg taaaaataac ataacgcgga 1815961 attttgtggc gggcgatttt ccctttgcaa taggctttaa gctcatcagg tgaaacgctt 1816021 ttaccgtctt tcagtttaat ccaggctgca gcttcctccc cgaatttggc gtcaggcaca 1816081 ccaaccacct gtacatctaa aacagcggga tgctggtata aaaattcttc aatttcccgc 1816141 ggataaatgt tctcgccgcc tctgatgagc atatctttta atcttccggt gatgcggcag 1816201 tacccgtctt catccatgac agcaagatct ccggtaaaca gccatccgtc atgattgatt 1816261 gcttttctgg tcgcatcttt gtctttataa tagcctttca tgacgtgata gccacgggtg 1816321 cacagttctc cctgcatgcc tctttgaact tcttgacatg tcccgggttc tacaattttc 1816381 acctcagtat gtggcagggc acggccggtt gtttcgactc ttcttatgaa ggaatcattt 1816441 gctctcgttt gtgtaatgac tggcgaggct tcggtttgtc cataggcgat cgtaatgtct 1816501 ttcatgccca tcctttcaat cacagctttc atcacttcac ttggacaggg agagccggcc 1816561 atgattcctg ttcggagcgt cgatagatca tatgcatcaa aatccggatg atgcagctcg 1816621 gcgataaaca tggtaggcac accatggagc actgtgcatt tctctttttc taccgtttta 1816681 aggacggtaa cgggatcaaa ttcttgcacg ggtatcatgg ctgccccgac ggatacacat 1816741 gccaaaaccc caaggacgca tccaaagcag tgaaaaaacg gaacagggat gcacatgcgg 1816801 tcttgagagg ttaaagccat acattcagcg atattagcag cgttattgat gacattgaaa 1816861 tgggtcagca tcacgccttt tggaaaccct gtcgttcctg atgtgtattg catattaatc 1816921 acattgtctt tatccaggct gttcattctc tcttcaagct cagcatctgt cactgttttc 1816981 gccaatatct ctgtatcgtc ccaatgatac atgccagaca atcgtttatt gccaatatag 1817041 atcagcgttt ttaaaaaggg atagcgttca gatttcagtt ggccgggctt tgcttcttgc 1817101 agttctggaa ttaaactgtt cacgatgtct ggataagaag tgcccctgta tgaatccatg 1817161 ataataagcg ccgcggcatc cgattgcttt aacaagtaat caagctcatg tgcttgataa 1817221 ttggtattga cggtcacgag cacggctccg atcttcgcag ttgcgaactg gacggcaagc 1817281 cattcagaga tattagaagc ccatatggcg acgtggtctc cttttccaat ccccatccgc 1817341 atgagacctt tagcggtttg acggcacaga ctgtcaaatt gagcgtacgt atagcggata 1817401 tttcggtctg gatacacaac agcatctcga tcgggatacg catcagctgt ttgttccagc 1817461 agcctgccga ttgtggaatg gatgagttca gccattcatt gttcctcctt tcttaatgat 1817521 aggaaagcgt ttacattttt attttaaaag ctgtctggcg atcacgagac gctgaatttc 1817581 agatgtgcct tcaccgattt ccattaattt tgcgtcccgc agcatccgtt ccaccccata 1817641 ctctttcata tagcctgaac ctccatggat ttgaatggct tgattgcaag ctcttgtcgc 1817701 catttcagat gcgaatagct tggcgtacgc cgcttctttg gtgaacgggc ggttatgatc 1817761 tttcagccag gcggctttta acaccatttg ccgtgccaga tcaatttcca tcgccatgtc 1817821 agcaagctta aattgaatcg cttgaaagga agaaatcggc tgtccaaact gctttcgctc 1817881 tttcgcatat gccaatgatg cgtcaagggc cgcttgggca atgccgactg caagagcagc 1817941 gatggagatt cgaccaccat ccagcgtata tagaaactgt ttaaaccctt ttgttggatc 1818001 gccaagtaag ttggccgcag gcactcttac atcttcaagc aagatttccg ctgtattcga 1818061 accgcggacg cccattttat cgtacgggct cgtaatcgta agtcctggtg tgtcagttgg 1818121 cacgattaat gcggagatga tgttttttcc gtctttgttt ttgcctgtta cggcggttac 1818181 aataactgtg cgtgcgtagc ttgcattagt gatccagcac ttttcgccgt tgattacata 1818241 ctcgtcacca tttgaaatcg cttttgtttg agtgcctcct gcatctgagc cggcatttgg 1818301 ctccgtcagg ccgaatgatc cgagtgctgt gcctgaagcc agcggcgtca aatgcgtctg 1818361 tttttgctct tctgttccga agtagtaaag agggcttgcg cctagcgaga ccgctgcagc 1818421 atagcttaat ccagtactgc cgcaggcttt gccgacttct tcaaccgcta aggcatatga 1818481 aatcgtatca ccgccagatc cgccgtattc ttctggaaat ggaataccca tcagaccgag 1818541 ttcacccatt tttttaaatg tttgcatcgg gaactcgcct gtttgatcta catgttcagc 1818601 gtgaggagca atttcttttt tcgcaaaatc ttttaccatt tcacgcacca tttgttgttc 1818661 ttttgtcagc tcaaaattca catcgtttcc tccttcacat ctttgtaaca tcctattagg 1818721 cgagttctat aatcattccc tgacaagaaa agtctgaaaa ttaaaactga atcatttttt 1818781 atgtgataat atcagcggga tgagcaaata catgcagtag gcgcatacca tccatatcgt 1818841 aaacgcaata acttggccct ttgataaagc cgggaagatg aggggaagat tccaaaggga 1818901 aatcgtatcc atcaataaac cgaccgctga tccccatata cctagcttga tcaccgcgaa 1818961 ctgtgattga tcgagttttt gatagagaaa gaacacaagg cataaaacaa gagcagtgcc 1819021 cgctcccaag agaagaaagt tcggcaaaaa ggcttcttca gccggatcag tcaacacagc 1819081 atctccgaac agcacaaaaa ataatgtggc acctaaccag actagaaatg aaaacgtaaa 1819141 acacgtcctg tacgtgtttc tcttcgattt tatttttatt tagtactagt ttctcagatt 1819201 ccaataatgg taaatgtcca aacaccgcct ccatattcat gtgaatctca cctttgtttt 1819261 ttaaaaaatt cagcggttta ccatcgtttc ctgtcccaaa atcacttttt aaaaaaagac 1819321 gacttagaaa gccgtccttc tcatttctta ttttgttgtt cgtttggaag ctttgctttc 1819381 gttatgaagc cggtctgctg aagtgacata atacgtatat ttcttgttgg gatctgccgt 1819441 gttatctaag aaggtttgct gctcatgtgt ttttctttgc gttgccagca atgttctctg 1819501 ctttttccct tcggctctgt atatcgcata ataggctgtt tctttcgttt tttgatttga 1819561 tgggtgatct ttaatctgca gaagattgcc gtttttgtct tcggtgactt tcgtaagctt 1819621 cggttttttt ggggcggtat tgtcaagcca aggcatttgc ggaaccagtg ccggcttgct 1819681 gtaaagatcg gtgctgagac tgtctttgat gccaagcgga tttttgttga ggtccttgag 1819741 gctgaaatgc atgcttcctt tcaccagttc aagctggcgg ttcaaagtga tttgccgcac 1819801 atattcctca ggatcggacc aaggcggatc aaaattgtta ttgattttat atgctgcctg 1819861 gccaatatat aagtgaacag gcctattttt gacttcattg ctccaccaat cagccagcac 1819921 gtcgtaagcc gctgcgttaa agccgatact ccaataaatt tgcggagcaa tataatcgat 1819981 gtcgccttct tggatccaat gccttgtgtc tgcatataga tcgtcataat ttctgacgcc 1820041 tgcttttgta ttcgatccgg tcgggtcatc tgcggcgttt ctccatactc caaagggact 1820101 gatgccgaat ttgacatacg gttttgcagc tttaattgtt tggttgattt gtttgacaag 1820161 ctggttcaca ttgtcccgcc gccagtcatc gatattagaa aaagcgtctt ttccgtattg 1820221 ttcgtactgt gcttgatcag gaaattcctg tcccgctatt ttataagggt aaaaataatc 1820281 atccatatga acagcatcga tatcataatg ttttacgact tcttcaatgc ctttgacgat 1820341 aaaatctctc gcttctggaa tgcctggatg ataatacagc tggtttccat aggcggcaac 1820401 ccaatctgga tgttttcttg ccgggtgatc ctcagacaat ttattaagat ctgtatgatt 1820461 cattgtaata cggtaaggat taaaccacgc gtgaaattcc aaatttcgtt tatgggtttc 1820521 ttcaatcata aatgcaagag gatcatagcc ggggtccttc ccttggacac cggttaagta 1820581 ttccgaccaa ggcccgtaag ctgacggata aaaggcatca gccgtcggtt taatctgaac 1820641 gataacggca ttcattccca ttttttgcac atcgtccagc agtttgatat actcctgttt 1820701 ttgctctttc acagataacc cttttttgga cggccaatca atatttaata cggaagcaat 1820761 ccatacggct ctcagctccc tgtcagactg cgcattggcc ataaacggaa cggaaatgac 1820821 aaacgttccg atgatcaagc tgacaaggaa acggacaatc gacttttggc aaaccttcat 1820881 tctgtttctt ctcccccatt acatcacttt cactattcgc tattacggta ttcccgggct 1820941 ataaaagggt gattaacaga atgtctatct cactaaataa acgaaaaaag tcctaaagca 1821001 tgttgtgaac cgcttttagg actttttatc attcatcatg gtttgcagac tttttaacac 1821061 atcaataagt tttacgccga caccgacagc cgtttcaagg atcgcttgtg ctccggcaat 1821121 ggctaaaata aagatcagcg gtattgcaat acgaggcaaa aaaagatagc caagtccgat 1821181 caagatggca caccaaacac cggcacacca gtagcaattg agcatgtatc caaagttaga 1821241 agccggcacg cttttttcat ctacatgccc gttttgatca acaatccttt tctttttcat 1821301 aaaaggtttt cggataaatt ctgtgatttt gtcaaataca atcaaatgtg tcagcctgta 1821361 actggctaga atcagcatga taaaagttag aaaagaaaga cggtccattg agaagcctcc 1821421 aagaaaaagg atgatgttat cattcccaag tgtcccttat ccattcttga tacaaaaaga 1821481 aagacggaca gagaatggcc tctgtccgct aatccgcttt atcgtttgtg cagtattact 1821541 tgatttgaag tgatcttttc taaaatgtcg aggatgatgt cggcattctt ttcagcatat 1821601 gttccttcca gcatgtcttt atgagcgcca aaacccgtgt actcactata gtttccgcag 1821661 gcgccttccc atttcgttaa gcctgtatgc ccgctggttt cggggtggat tccagcttcg 1821721 atgaaatgaa tgcttgcttt gatgtggcct tcattcagca attgtgccca atattcctga 1821781 tagtttcttt ttttcttcat caccttttct ctgactgctt caggcagata tgctgcagat 1821841 tcgtcattac cggtatcgat aggcaaaggc tgttctttta gataagcgtc cacgataatg 1821901 aagtcgctga cttctaatcc tttgcgctcc atagcctgtg ccacttcaaa agccaggttt 1821961 ccgcctgcag agtagcctaa taaaacgtat gggccctcag gctgtatgtc cgtcatgcaa 1822021 ttaacatatt gttcaatgcg ggtgtcttgt tcaataaagt gaaacccgta tacggctgcc 1822081 ttctcattca gcaataaagc aaggtcttta aaataaatgc caaatcccga tatcggcggg 1822141 aagcagaaaa gattttgcgc gccgtgctgg ttcagtttga tcacatgctg ttcatttgct 1822201 gctgtcagct gtttagaata aagtttttcg gcaagctgag cgattgtcgg atgttcgaac 1822261 aagaaatcaa tcggtatgtc aatgttctgc tgatgtttta gtgtatgtat gacttgcagt 1822321 gctcttagtg aatgtccgcc aatagcaaag aagtcatcat caatactgat tgtgttaaca 1822381 ccgaggactt gcttccaaat gttcgccaat tcttcttcaa ccaagtttct tggcaatatg 1822441 atgttctgtc gtttggcagg cttattttct ggaataggca gcgcgctgcg gtctattttt 1822501 ccgtttccgg taagcggcat ccgctccaca cgcacccagt gctgcgggat catatagtct 1822561 ggaagcacac gcgccaaatc ggcgcgaaaa tccgtatctg tttttttgtg atcaccgacg 1822621 taatgagtgt acagctgcgc ctctccatct ttttctctca atgtcactgc tgcttcttga 1822681 acgccttcca tttctaacag gcgcgcttct atttcggcag gctcaattcg ttttccgcgg 1822741 attttcattt gcctgtcaat tctgctgatg tattctaagt ttccatcagg cagccagcgc 1822801 gccaaatcac cagtacggta tattctttct ccaggcaaga aaggatgagg agaaaacaca 1822861 gcatttgtca gatctactct gttcaaatag cctttagcga ctccatcacc gccaacacaa 1822921 agctcgccgg gaacgcctat tggcaaaaga cgtccttttg tatctaagat gtaagcggtg 1822981 ctattactga ttggttttcc aatcggaatc ggccccgcat agtctctctt catttcaaaa 1823041 aaggttgaaa aagtcgtgtt ttccgttggc ccgtaaatat tatgaagcgc gagatctgga 1823101 caggcgtgtc tgacggcatt catcagggca ggagagagtg cttctcctcc gacatataac 1823161 gtatggagtc cgcgaaacat gtcagctcgt acctgtgcca gctgattaaa aagagctgtc 1823221 gttaaaaata gcactgtaat gtcattttca agcaaatacg ctccaaaccg atcaggtgtc 1823281 agcattgtcg atttatcaat gatatgaagg cttgcgccat ttaaaagtgc cccgaacatt 1823341 tcaaaggtga cggcgtcaaa gctgatagat ccagtcataa taaaccggtc atcaccggac 1823401 gcagacgtgt aattgctgtt tctgacaagg gacacgacat tgcgattcgt gatcatgacc 1823461 cctttcggcc ggcctgttga tcctgaggta tacatgatgt acgcaagatc atccgggctg 1823521 gagctgatat taatagggat atcgttctct tccatcaatc cctgcgcatc tgaaatgata 1823581 catgttcctg agaacgcagc gttttgctcc aatccctttt gaacaatcag catttttgcc 1823641 tgcgtttcct caagcataaa gctgactcgt tcaggcggaa gctccgcatc aagcgggagg 1823701 tatgctcccc ctgcttttaa tacggcaagc acactgatca tgaattcggg agaatgtgca 1823761 gccaatattc cggctgtctc gtttttccga aatccctttt gaattaactc tctggcgagc 1823821 gcattagagc gtttatcaag ctctttatac gaaatagaca tattgccata cacaagtgcg 1823881 gtatggtctg gcgtcttttc tgcttgttcg cgaaataaat cgataattgt atgattcttt 1823941 ggatactccg tttttgtatt gttgaactgt gtgacaatct gctctttttc tgttgcatca 1824001 agaaaagaaa aatcagcaat tggcatatga gggtgctgtg cagctgtgct aagcgcttgc 1824061 gtaaattgcc tcttgataca gctgatccag gcagcatcgt aaacgaatgc attatagctg 1824121 aacttgatga caagctcttc gccaggagca acgacaagat taaagttata tcctgattgc 1824181 tcggatactt gaacttgatc gatttgcagc ggtgaatcgg tttgatcagc ggaatcggcg 1824241 attttctgct gtaacggata gttttcaaag acgataatgt gatcaatcag ttcctgtttt 1824301 aatgcggtgt ttgcctgaat atcaaataaa ggctggcagg taaacggctc agcttccagc 1824361 atttctttct ggcagcgtat gagcagctcg tgaaacgttt cgtcttggtg tgttttaatt 1824421 cgaatcggta tggtattgat aaacaaccct atcatttgct ccacgcctgg gatttctgac 1824481 ggtcttcctg atacaactgc gccaaacaca acgtcgtctg tgcggttata ttgctgcagc 1824541 atcacacccc agactgcctg aataagggta gcgagcgtga cgccgtgttg tttggcagtc 1824601 tctttcagct tgtctgtcag tggtttattt aatgaaaata tcaaatcttc acggtgataa 1824661 ctttcttttg tttctttatc agacacacga ggcagaggtg atggagcgct gtagtttttt 1824721 aaataggtat cccagtaggc cgctgctttt tctttgtctc ggtttgtcag ccatgaaata 1824781 taggtgctgt acggacggac agggtctaat gaaagcggtt ttcctgcatg aatcgattga 1824841 taaatttgca taaattcctg cataacgata cctaggcacc atccgtccat taaaatgtga 1824901 tggtgactcc agatacagac atgctcatct ttagctgttt tgaatagaga aatccgcatc 1824961 agcatgtctt tttgcagatc aaagcctttt tgcttgtcct tctctttaaa gcgttcaata 1825021 tactcattct ggtcgtttgt cggcagatga gaaatgtctt cgctgttcaa atggaattca 1825081 cgttctgtca tcacgacttg ccgaggtccc gacaaatgcg ggacgtgcgg caaaaacacg 1825141 gttctgaaaa tatcatggcg gtcgataatg gcttgaatgc tgcgctggaa ccagtcatag 1825201 ctgaggcttc ctttaatggt gaagagcgac tgctcaacat acgccccctc ctctttacgg 1825261 aggaaggaat gaaacagcat cccttcctgc atatgactca gaggataaat gttcttgatt 1825321 tttttaatgg tattcatagt gtctgcacct ttcttcacgg attcattagt gaaaactgag 1825381 catatcagcg atctcttgca gggcgtcctc ggtcagttct tgatcatcaa aatcactgat 1825441 cgtcttttct gtttcgcttt tgttctggca gtgttcgatc agctgtaata aaaattgacg 1825501 gcatgtttcg ctaagctgtt cgatggtttt gcgctgaaag cgggcattgt cataagtcat 1825561 attgacagtc aattttcctt ctgcagcgat tgcgctgata tccagcgact gttcacggtt 1825621 ccatgttgtg ctgatatcac ctccggcacc cagcggagag aatgagaagg cgtcctcctc 1825681 aggtacttca gctgtgcggc cgctttcaaa ttgaccaaga taattaaagc tgatttctgg 1825741 tgcacctgtg aaattgatgt cttttttgcc aggcggagtc aaatatttga tgacaccgta 1825801 gccgaatcct ttgtcaggta cacgtctcag tgtatctttt gttgttttta gcacatgaac 1825861 catgctttct tccgaatctg gcaagtctgc gttcagttta atcaataacg gataaatggc 1825921 ggtaaaccat ccaatcgtcc ggctcacatc tattcctttt aatacatcct ctcgcccgtg 1825981 gccctctaat gatagtttga aggcggattg attggtccaa tggcgcagcg caagaatgac 1826041 agaagcgagc agcatgtcct gcgtatcagt gttatatgcg ctgttggcgt cttttaagag 1826101 tgctgctgtc tctttatcgt ttaaggtaaa cgaaattgtg gaccgttgtc cctcgtgtgc 1826161 tctagttcca tcgatttgat caaaaggcaa tgcctctgtt tgatactctt cggcttcgcg 1826221 ccaatacttg agctgtttca ttagctgctg gctttcagcg tagtcagaga gctttttcgc 1826281 atacgcttta aacgagcttg ttttaggcgg cagtttgata tcctccccgc cagcagcttg 1826341 gcgataccct aaagccaaat cttcaagcag aacccgccat gagatgccgt caacgacgag 1826401 gtgatgagca gataaaaata agaaatcacc gtcaattgtg tggaaaagac cggcttgcag 1826461 cagcggacca ttcttcaaat ccattttctg ctgaatatca agtacatggc gcttgataag 1826521 aggttcatac ggtctatttc catcagtgcc gtccggagct gacaaatcaa tcatctgaag 1826581 gccgtacaac gcgtcgtccg aatgactgag cggccgatta tattgatccc actttccttg 1826641 ttcattctgt gtaaacacca ttcgcagcgc atcatgatga cacgttattg cttttaacgt 1826701 ttttcgcagt gcgtcttctt gtacagaggt gcttcgatgc agcattacgg actgattaaa 1826761 atggtgtttt tcttttatat cttgagaaag aaaccatttt tgaacaggcg accattgtac 1826821 gtctccctca accgcagctt ggctggaact tgtatctgaa tcacggatat aagctgccaa 1826881 ttcttgaatg gtcggatggc taaacaaatc tttcactgcc atttgcttgc ctatccggtg 1826941 aagccgcgca gatacctgta acgctttgat tgaatctccg ccaagttcaa agaacgaatc 1827001 agctgttccg atcttttctg cccccagtac ttctttccat atatctgcca gtatttgttc 1827061 cattttgctg gatggcggga ggaatggacg ttcaccttcg tggttgtata caggttttgg 1827121 aagtgctccg cgatccagct tgccgtttgg tgacaatgga agtgagtcca gtttttcaat 1827181 aaacgcaggg tgcataaaca ccggcagctt gttttgtaat tctgagcgta cagcatttgt 1827241 gctcaaccct ggttttgtca ccacataagc gcttaattcg gtttgtcctg acgctgttac 1827301 atgagcaact actgcggcgt cttttacacc ctttatacac cggatgaccg attcaatttc 1827361 tttcgtttct acacggtatc ctctgatttt gacttgatca tcgattcttc cgagatattc 1827421 gagtgtaccg tcggccatcc atctggcggc gtctcctgtt cggtacattc gtgcttcggg 1827481 tttaaatgga ttctgcgtga atgctctctc tgtcagttct ggaagattaa cgtaccctct 1827541 tgcaagccct gttcctgcta tacaaagctc tcccgcaaca ccgattggct gaagctgatg 1827601 attgctattt aaaatcagca cttgagttcc gtcaatcggc tggccgatgc ttacgtatgc 1827661 ctgcttttcc atatgtctca tgacggtagt cgccacgctg ttttctgtcg gtccatattc 1827721 gttggcgagt tcggtatgcg gacatatagc taagctgcgg gcgatcaatt cgcggtcagc 1827781 cgcttctccc gccagtgtga cgactctaag cgtctttaca tcttccggct gcactacgtc 1827841 caaaagcgct cgatataaaa caggcacaat aatcatatgt gtaatccgtt gacgagacag 1827901 ctgatgctta atggccagaa tatccttcgc ttcctcttca tgaagcaaaa cggcttttgc 1827961 acctgacaaa agcggtgtaa acatactagt tataaagccg tcaaatgaga aagaaaagag 1828021 ctgcagaatg gtatctgtct cgttgaatgc ataagcgttt cgccgccact gaagagtgtt 1828081 agcaatccct ttatgctcga ccattacccc ttttggacgg cccgtcgttc ctgaagtata 1828141 aatgatataa gccaaatgat gggcagacga catttgcggc agcggcgatt tgtcgtcttc 1828201 ctctacgctt tctatcgtca agatctctcc ttcaaagtca gcaagtactc ccagatccgc 1828261 ttcatttatt gtcatcagca gtttcgttcc gctgtcgctg aggatatagc gtttccgttc 1828321 tttcgggtat tcaggatcaa tgggaacgta acagcctccg gctttccaca caccaagtat 1828381 ggatgctatc atactgaacg aacgatgcat catgatgcct actggtgtgt ccggcttaac 1828441 acctcggctg cgcaatgcac gtgcgattcc attggaccac tcgtcaagct cctgataagt 1828501 gagtgttttg tctccgctga caagtgcaga agcttttggt gttcgtgcag cttgctgctc 1828561 aaacaattga ctgattgttt gaactccgta ttgattcgct tgcccggtgt taaactcatt 1828621 aagcagctgg tgccgctctt cttgggtcag gatgtcgata tggttgagtg tcaccttcgg 1828681 gtttttgccg atgatgctaa gtacatttgt taaatgcgat gcccagcgtt caatggtggt 1828741 tttctcgaac aatgcggttg aatattcaaa aaggaaatga atgtttccgt cgccctcaga 1828801 tgcctgtagt gtcaaatcga atttagaaac gagatgagaa acttgtgccg gcttcatttg 1828861 caaatcatga agatgcaatg gctcgtaatc attattttga acaactaaca tcgcatcaaa 1828921 cactgggttc cggctcatat ctcgtgtcaa ttcaagctta tcgacaagct cttcgaacgg 1828981 gtaattctgg tgctcaaagg cttccaatgc tgtctcacgc acttcctgca aatactgtac 1829041 gaatggcttc ccgccctccg ggcgcgtccg aagcgccagc gtgttcacaa acatgccgag 1829101 tatcggctca agatccttgt gcggccggcc ggcgattggc gagccgacga tgatatcttc 1829161 ctgtccgctt aagcgtgaca agaacgcggt gtaagccgca aggagcacca tgtacagtgt 1829221 gcttccgttt tctcgtgcca gcttgtgaag gcctgatgca acctctggtt ccagcgtaaa 1829281 tgagaccttg tcacccgcga agcttcgcac cggcgggcgg gcatgatcag cggggagatc 1829341 cagcacaggc agctcgccct cgagctgctt cagccagtac gcctcctgca ttttgtacgc 1829401 gtctcctgtt ttgaatcctt cttgccatac ggcataatct ttatattgaa tgcgcagcgc 1829461 cggaagcttc cgattattgt acagctcgcc gaattcttga atcagaatgt tgacggaaac 1829521 accgtctgaa atgatgtgat gcatatcaac cagcaatagg tgccgctcat ctgatacctt 1829581 tacgatttgg gcacggaaca gcggcgcttg gctgagatca aacggtttga taaatgcggc 1829641 tgcggcctcc tgttcggttc gtgcgccgag aactgtagtc tgtaacgtaa acggcacctc 1829701 gtcatggatg cgctgcaccg gatcgcctcc ttcgtcctgt tcgaaggagg ttcgaagcga 1829761 ctcgtggcgc ttgatcagct cttggaaagc tctgtccatc ctttcagggt tgagcttccc 1829821 ttcgagctct aacacagccg gcatattgta gcctgtccct ccgtcctcca gctgctgaag 1829881 gacataaatc cgcttttggg cagaggaaac cggataggtt tcctgttttt cagcgggctt 1829941 aatcgcttca tatggactgt ccgttccttc acggataacg gtagccagtc cttctaccgt 1830001 cggatgggca aacacatctt ttagcggcac ctgtacatcg aattctttgg tgatccgtga 1830061 gacaagcgcc gttgctttta aggaatgtcc cccgcggtca aaaaagttgt cgtgaatccc 1830121 gacagggcca tttttcagca cgtcctccca cagctgagaa agcttcatct cagtcacgtt 1830181 tctcggcgct gtgtaggtct ccgcatctgc cgctccgcca ggagctggca gggcgtttcg 1830241 gtcgagcttt ccgcttggcg taaccggcca ctgttccatc tctatcatat aggctgggac 1830301 catgtagccc ggcaacagtc tctcaagctg cgctcggact tcgtttcttt ggagcccttc 1830361 tacataagcg cataattccg gctccccgct gtctgtccgt acggtaacgg ccgcctctct 1830421 tacaccttct atacttctta gtgccgcttc aatttctccc ggctcaatcc ggtagccgcg 1830481 gattttcacc tgatcatccg tgcgcccgag gaattcaaca ttcccgtcag ggagccagcg 1830541 cgccacatcc ccggttttgt acatgcgttc acccgggtaa aacgggtctt caagaaaacg 1830601 ctcctccgtt aatgccggcc gattcaaata acctctggca acacccgctc cggctatgta 1830661 cagttcgccg atacatccaa caggcagcat ccgctgattc tgattcagga gatataatct 1830721 gacatgatga acaggttttc caattgggat ccgttcaagt ttttcatgcg gcggacaatc 1830781 aaagaatgca gcttctacgg ttgcttccgt tggcccatag gaattggtta ttgaaacatt 1830841 tggaagcaac tcgtaaaatc gggagacaag atgggtcccc agctgttctc ccccagaaaa 1830901 cactcgcttg agtctgtttg tcttaatcgg tacagagcga tattttatat gttctaaaaa 1830961 tgcatggagc attgaaggca caaaatgcat agctgtgatc ttttgttctt ctatggcctt 1831021 cgcgatcact tcaggttctt tttcgcctcc ctgaggaagc agataaacag aagctccggc 1831081 ataaggccac caaaacagct cccatattga agcatcgaat gaatatgatg ttttgtgcat 1831141 aatcatatct gaatgcttta gctgatagcg ggactgtagg gaattcaaaa aattcaccgc 1831201 tgatcgatgt tcaatttcaa cacccttagg catcccggta gagccggatg tatagatgac 1831261 ataggctaaa gattgcggga gaacatccac attcggattg gacaaacgat gtgccagtcc 1831321 gctatttgtc tgattgagat agacaatctc tcctgtaaat tccggaacat gaaggccggc 1831381 agactgaagc aggagaatgt ttgtaccgct gtcctccagc agaaagctga ttcgttcttc 1831441 cggataatcc gggtcgatgg gcagataagc gccgccagct ttaagaatgc cataaatgcc 1831501 aagcagcatt tcaggtgaac gctttcctat aatggcaaca gtcgtttcgg gttttacccc 1831561 ccgtccgatc agctcccagg cgatacggtt agcctgttcg ttcaattctt tataggtcat 1831621 cactccatct tcgaagataa cggccgcctg atcaggcgtt ttttctgcct gctgttcgag 1831681 tgcatagtgg agcgtttgat tcattgaata gcccgtctcc tcaaacagat ggcatgattc 1831741 aatgaaatct cgctcttctt cttttgttaa gattggaata ttgtccaatt ctgtttcagg 1831801 actggcagct gtatgttcca caagcgtggt gaaaaggctg gcccaccttt ggatggtttc 1831861 tttctcaaac aaagctgtac tgtattcaaa ctgacagaaa agctcggaat catgctctgt 1831921 aacgtatagg gaaatatcaa attttgatat tgggtgctcc aagtcgttcc actgaagctg 1831981 tacatcattc atttttagct tttgctgttc catattctga aggactagcg ttgtgtcaaa 1832041 caaaggattc cggctcattt cccgctgcac accgagtttg tccacaagct cttcaaacgg 1832101 gtaatcctga tgctcatacg cttctagtgc cgtctgtctg acttctttca gaaattcctc 1832161 aaatgtctta ttacccgccg ggcgtgtgcg gagagccaat gtattgacga acatcccaag 1832221 aacagcttca aggtcggcat ggggccgtcc ggcgataggt gaaccaatca cgatatcatc 1832281 ctgaccgctt aaccgagaca aaaaggctga atacaaagcg agaagcgtca tataaagcgt 1832341 gcttctgttt ttatgggcga gccgctttat gcgggccgtg atctctttgt ccaattgaaa 1832401 ggttactttt ccgcctatga attgccgttc tgccggacgt cgtttatctg ttggaagctc 1832461 cagtatagga aggtccccgc taaactgctg ctgccagtaa gtctcctgct tttggtacga 1832521 gtctcccttt ttaaatttct gctgccatac ggcgtaatct ttatattgga tccgcaatgg 1832581 cttaagctgc cggtttgcat aaagatcggt aaattctcgg attaggagct gaacggatac 1832641 gccatctgaa atgatatggt gcatatccac cagcaataca tgcttctcgt ttgacacttc 1832701 tataaggcct gctctaaata atggcgcctg gctgagatca aagggacgga caaatccctc 1832761 gatagtggtc tctttactta acgtaaacgg cacttcggtg tggatacgct gaaccggctc 1832821 gtcatcagct ccggatacaa aggaagttcg aagcggctca tgccggctga tcagttcttt 1832881 acatacagca gacagtttgg cgacatccag tgcaccttcc agttctaaga ccgcaggcat 1832941 gttataggcg acaccctcat caagctgttg aagcacatag attcgttttt gggccgaaga 1833001 tacaggatat gtatcccttt tttctgctgg ttcaattgct gcatacagat tttgttctgc 1833061 ctctcgaata attaaagcta atccttcaac agtcggatga gcaaagatgt ccttaagtga 1833121 aacttgcaca tggaattcct ttgcgatccg tgacataagc actgttgctt ttaacgagtg 1833181 accgccattg tcaaaaaagt tgtcttggat gcctatatgc ccattcttta gcacatcttc 1833241 aaatagttgc gaaagctttg cctctaacag atttcgaggg gcagtatatg ggtttccgct 1833301 gattgaagca tctggctccg gaagtgctgc gcgatctact tttccgtttg gggtaagagg 1833361 tatgctgtca acccatatcc atttcgccgg aatcatgtat tctgggagct cactagccat 1833421 ataactgcgt aaatctattg tgttcagctt ttgtacactg caatagtaag cgcataattc 1833481 atgttcaccg ttttgatctt gccagatgag aatggcagcc tcactaatgt ccggatgatt 1833541 cattagcgtg acttcgattt cttgcggctc aattcgataa cctctgattt tcacttgatt 1833601 gtctgcccgt ccgatatatt cgatgttgcc gtcttcaagc cgtctggcca aatcacctgt 1833661 ccggtacatg atcacatcag gcttgaatgg atcggatgaa aatttgtcgc ttgtcagttt 1833721 atcgtgattg acatatcctc tggcaacact tgcgccggaa atatagagtt cgcctggtac 1833781 gccgcatggc tgaagctgtt tttgatgatt caaaatatat agatcagtac agcctatcgg 1833841 tttaccgatt ggcggaagct caggaatagg gtctccagga tgaatggtat acgtagatac 1833901 cacatgagtt tctgaaggtc cgtaatgatt gtgcaggtgt atgccgcgtt tacgcaacac 1833961 atcttggaaa aggtctgaaa tcattaattg ttccccggct gcgatcaggt gtttgacgcc 1834021 atcaggaaac gagttcgcaa gttctcgctc gctgaaaatc attttgataa aagcagttgg 1834081 gagaaacaca atattcgtct gatgcttgtt tataaatgca aacagctgag gcacatctct 1834141 ttttatggct tctggcacga tgtggagtgt gccgcctttc agaagcgcag aaaatatttc 1834201 ttgatagcag acgtcgaagg aaggcgtcgc aaattgcaga acatctgctt caaagtcaat 1834261 gccggagtga gtatattcga acttcagcaa gttagccatg tttcgatgct caaattgaac 1834321 accctttggt ttacctgttg tgcctgatgt ataaatcata tacagcagat cgtcagcatt 1834381 gttgactgac tttatgttac tgccgtctac tttgctttcg atatcttctg gatgagtgat 1834441 aatgtaattg tcttctaacg atgagggaag atgcgcttgt gaaacaacat gcgaacagcc 1834501 gcaatcatgc agaatataac ggattctgtc agcagggtaa tgcggatcaa ccggaacaat 1834561 ggcgccgcct gctttcaaga taccaagaac acctgtgata aacgccgctg agcgttccat 1834621 cataatcgca acgggttcct gtctcacaac gcctttcatt cgtaaatgcc gtgccaatct 1834681 gttagccgct ttattcagtt ctctgtatgt taatgagcag gcttgatcaa ttacagcatg 1834741 agcatctggt gtcttttccg cttgcttttc aaacatggca tggatggttt cgtaaactgg 1834801 tgtttgatct gtgatttctc caatcagctg ccgcttttca gtatctgtcg tgatatcgat 1834861 ttcttcaggt ggaagattcg gattatttaa gatttgtgat acagcattca gaagatgctc 1834921 tttgacagag agcacaaaag accgatcgtg ctgctccgca tcatagttca ttttgatatg 1834981 aatttcttcc cctggcgcca ccataagata aaagctgtag ttggtttcat ctgcgacagt 1835041 gaaattatga atctgaaaaa gatcagaagc atgttcctgt ttgttcagca tttgaatctc 1835101 ttgctgcacc ggatagtttt caaatacgag aatatgatca atcagccctt gcttaacagc 1835161 tgagcgggat tgaatctcat ataaagggtg gtagctgtac gcttcagcgg caagacggtc 1835221 tttttgcata tcttttataa gttgaagaaa aggcgttttt gccccctgca cccgaaccgg 1835281 catcgtatta atgaaaagac ctaccatatg ttcaatgcct tcgatttctg cgggtcttcc 1835341 tgaaatgaca gaaccgaata cggcgtcatc gttattatta tatttttgca gcagaatgcc 1835401 ccaaatggta tgaaaaatcg tactgagtgt cacttcttct ctagcagcaa gctctgaaag 1835461 cctgctgctt tcttccttag agaatgaaaa tgtaacgtgt tcctgcctgc tttttccctt 1835521 tgtttttttc tgcttcggga gcacggtttg ctgttcgtgg ccggaaagat aatgatccca 1835581 ataagaaacc gcctgctctt tgtcttgctc catcagccat ttgatatact ttccgtatgg 1835641 ctggaccggc tccaatgtta ttggggatgc atttacataa gatgcgtaaa tatgcagaaa 1835701 ctcctttagc acaatgctga ggcaccaacc gtccatcatg atatgatgaa aggtccaaat 1835761 gcaagagtac tggctctctc ctgtttgaat cagagcgatg cgcatgagca catccttttg 1835821 caaatgaaac ccccggtccc ggtccttttc tttccattgc tcgataaact gtgattgctc 1835881 cgcctcgttt aaatgagtaa tgtcttcttc cagtacgatg acatttcgtt ctctcagaac 1835941 aacctgctgg ggggaggaaa cattttggct gataaaaatc gttctgaaaa tatcatgtct 1836001 ttctacaaga gcgttgatgc tgttttgaaa aaactgcggg ttgacttttc cttctattgt 1836061 aaaagaagct tgctcaacat acgcctgtga atctttttgc aggagggaat ggaaaagcat 1836121 cccttcctgc atgtaagaca gcggataaat atcctgaatt gaattcgctt ttgtcatgtt 1836181 catgtctcct gtcacgattt tctacaattc ttccaccaag ctggatatgc tgtccaagtc 1836241 ctctgccgtt aatgattgac tgctgaaatc gctcagtgtc ttttctgctt tctgttgacc 1836301 ggcgcagtgt ttcataatgt ccagcaaaaa gtgttcaatc ctgttaataa gctgttccat 1836361 tgtgtttctg tgaaagcggg ctggcggata actaagattg aaatggagct ttttgtctgc 1836421 tgccattgca ctcatctcga tgatttgctc gcgcttccat gtatgagtga tatcctttcc 1836481 gctaccaagg cttgatgggc ggaaggtgtc ctgtctttcg atgtcgttga actggcccaa 1836541 atagttaaag ctgatttcag gtgtttttga aaacgtaatg cttttatttt cagggtgtgt 1836601 aaggtatttc agcataccgt aacctacccc tttgtttggt atccggccca gtgtatcttt 1836661 aacggttttt actgaggttc cgagctcatc cctatgattt tcaaagctta tgagggccgg 1836721 gtacatggat gtaaaccagc cgaccgtcct gcttatatct aactctggca gaatgtgttc 1836781 tctcccgtgt ccttccatag cgatacggag cttgcttcct cctgtccatt cacaaatcgc 1836841 caaggatgct gcggttaaca gaatatcttg tgtatctgtg ccataggcgt gattgacgtt 1836901 ttgcagcaag acggcggtgt ctgcttcagt cagtgaaaag cttaatgagt cccttttgct 1836961 gaagtcgatg ttcacatgat gcggtatttc atagggcagt tctgcggctt gctgttcttc 1837021 tacacttcgc caatacgcct cttcgcgaat cagcttactg ctttgggcat attcctgtat 1837081 gcgtcttgcg tattcctggt aggaatccgt tttaggcgga agctggatcg tctggcctgc 1837141 agcagcttgt tgatatccgg ctgacaaatc ctccagcaaa atccgccatg agacaccatc 1837201 aacgacaagg tgatggatcg caaggaacaa gtaatctccg gtcagtgttt taaacaaagc 1837261 ggcgtgcaac aatggtcctt cctgcaaatt gatgctttgc tgaagatcgg caacttcttg 1837321 tttgattttc gtctcccagc cgctttctga ctgtgaaaga tcagagattc ttaagctgta 1837381 tagctgtgac tcatgaatgc cttggttgat ttgaatccat cgcctgtcat cgttgcgata 1837441 aaccatccga agcgcatcat gatgctccgc cagttttttc aaggctggtc taagggcgtt 1837501 ttcagacaaa cgtccagaat ggaatagcat gacagactga ttgaaatggt gtctttcttc 1837561 aatatcttgt gaaaaaaacc attgctgaac aggcgtccaa ggaacgtcac cctgaatggg 1837621 tccttgctct atgattctct ctgacttacg gataaatggt gataagtcct ttatctttgg 1837681 atgacggaat aaatcactta cctgcaagct tagtccatag cgcccaaggc gtgcagaaac 1837741 ttgaagggct ttgattgaat ctccgcccaa ttcaaaaaac gaatcctcta ttccgatcct 1837801 ctggatgcct agaacctcct gccagatcaa tgccagctgc tcttcaagtt cgttgcgtgg 1837861 cgggatgtat gtttgtttag atgcgacatc tggttcaggc agtgctttcc ggttcaattt 1837921 gccgtttgat gtgagcggaa gagtctccat ttcaatgata tacgccggga tcatatagtt 1837981 tggcagcgaa cgcgcgagaa gagaacgcac ttgttcagca ttcgtgcctg cttttacgct 1838041 gatatagcca aacagctctt tgctcccggt ctgggctgta cgtgctaaca ctgcggcttc 1838101 tttgaccccg tctatttgac gaagtgctgt ttcgatttca cccagctcca cccgatagcc 1838161 tctgactttt acttgatcat caatacggcc aacgtactca attgtgccat cggaaagcca 1838221 gcgcgccaga tcacctgtgc gatacagtcg atcgccaggt gcaaatggat gtgggacaaa 1838281 tttctctttc gttaaatcag gacggcccaa atatcctctg gcgacgccat ctccgccgac 1838341 acaaagttca ccgacagctc cgaccggctg cagcactccc cattgattta agataaaagc 1838401 ggtggaatta ccaaccggcc gcccgatcgg aatggaaagt tcatatgttt tttgaatgtg 1838461 aaggcatgtc gaaaaagttg tattttcggt agggccatat ccattccata tagatacttc 1838521 agggcagaca tttctgattc gattgacgtg gctcggcgac aaagcttctc cgccaataat 1838581 caaatgtttc agctgtgaaa atgtttgttc attttgctct gtcaaatgat tgaatagaga 1838641 agatgtcagc caaatcgttg tgattccttg atgttctatg tacctcttaa gctgatggga 1838701 atcgagaaat gtttgttgat cggacagatg caaagcggca ccatttagca gcggtccgaa 1838761 aatttcaaat gacccaacgt cgaaaccgat tgatgatgtc atcagaaggc ggtcttcagg 1838821 tgtaaatgta atataattgc tgtttttaac aagacgaatt acacttcgct gctcaatcat 1838881 gacacccttt ggtttaccgg ttgatccaga ggtataaatg atatatgcaa gtgaatgggg 1838941 ccctgctgaa gattcaacgt tcttcgcctc tccttgcttt tgaatatctt cgattatgat 1839001 ttgttcacat tcaatgccta atagccgttt ttctgttttt tcagattgaa ggagtaatgc 1839061 tgccctgctg tcagacagca tataagctat gcgttcaaca ggcagattag aatcgatagg 1839121 cagataggct cccccggctt ttagaatgcc cagcattcct gcaatgagtt ctggtgttct 1839181 gcctgtcaac aaggctacaa cactatcagg ccctacgccc tttatctgta gaactgaggc 1839241 aatttgattt gcccagctgt tcaggtcctc gtaagtgaat acttgggtgt cgctgacaat 1839301 tgctacagca ttaggtgttt gttctgcctg catttcaaag agtctgctga tggtttcatt 1839361 tcttggataa tctatttttg tacgattgag ctcgtggata aggtaatggg cctcatcctc 1839421 attcaggata tttattgttc cgagagcggc tttgttgtct ttgatgatgg agagtaacat 1839481 attgttgaag tattgaagcc acttttctat cgtttttttc ttatataagt cagtactaaa 1839541 ctccatttgg aacgtcagca aaccgcgggg ctgttcctgg gcatataggg ttaaatcaaa 1839601 tttggacgtt tgatgcccat tgtttgctgc aggtttgaga caaagttcat ccagctccaa 1839661 cgattcctga tccatatttt gaagaacaaa cattacgtca aacagcggat ttctgctcat 1839721 atctcgtgtc aattcaagct tatcaacaag ctcttcgaac gggtaatctt ggtgctcaaa 1839781 ggcttccatt gctgtctcgc gcacttcctg caagtactgt acaaacggct tcccgccctc 1839841 cgggcgcgtc cgaagcgcca gcgtgttcac aaacatgccg agtatcggct caagatcctt 1839901 gtgcggccgg ccggcaattg gcgagccgac gatgatatct tcctgtccgc ttaagcgtga 1839961 caagaacgcg gtgtaagctg caaggagcac catgtacagt gtgcttccgt tttctcgtgc 1840021 cagcttgtaa aggcctgatg taacctcttg atccagcgta aatgagacct tgtcacccgc 1840081 gaagcttcgc atcggcgggc gggcatgatc agccggaaga tccagcacag gcagctcgcc 1840141 ctcgagctgc ttcagccagt acgccccctg cgttttgtac gcgtctcctg ttttgaatcc 1840201 ttcttgccat acggcataat ctttatattg aatgcgcagt gccggaagct tccgattatt 1840261 gtacagttcg ccgaattccc gaatcagaat gttgacggaa acaccgtctg aaatgatgtg 1840321 atgcatatca accagcaaca ggtgccgctc atctgatacc tttacgattt gggcacggaa 1840381 cagcggcgct tggctgagat caaacggttt gataaatgcg gctgcggcct cctcttcggt 1840441 tcgtgcgccg agaactgtag tctgtaacgt aaacggcacc tcgtcatgga tgcgctgcac 1840501 cgggtcgcct cctgcgtcct gttcgaaggc ggtccgaagc gactcgtggc gcttgatcag 1840561 ctctttgaaa gctctgtcca tcctttcaag gttgagcttc ccttcgagct ctaacacagc 1840621 cggcatattg tagcctgtcc ctccgtcctc cagctgctga aggacataaa tccgcttttg 1840681 ggcagaggaa accggatagg tttcctgttt ttcagcgggc ttaatcgctt catatggact 1840741 gtccgttcct tcacggataa cggtagccag tccttctacc gtcggatggg caaacacatc 1840801 ttttagcggc acctgtacat cgaattcttt ggcgatccgt gagacaagcg ccgttgcttt 1840861 taaggaatgt cccccgcggt caaaaaagtt gtcgtgaatc ccgacagggc catttttcag 1840921 cacgtcctcc cacagctgag aaagcttcat ctcagtcacg tttctcggcg ccgtgtaggt 1840981 ctccgcatct gccgctccgc caggagctgg cagggcgttt cggtcgagct ttccgcttgg 1841041 tgtaaccggc cactgttcca tttctatcat ataggctggg accatgtagc ccggcaacag 1841101 tctctgaagc tgtgcacgca cttcgtttct ttggagccct tctacataag cgcataattc 1841161 cggctcgccg ctgtctgtcc gtacggtaac ggccgcctcc cttacgcctt ctatgcttct 1841221 tagtgccgct tcaatctctc ccggctcaat ccggtagccg cggattttca cctgatcatc 1841281 cgtgcgcccg aggaattcaa cattcccgtc agggagccag cgcgccacat ccccggtttt 1841341 gtacatgcgt tcccccaggt aaaacgggtc ttcaagaaaa cgctcctccg ttaatgccgg 1841401 ccgattcaaa taacctctgg caacacccgc tccggcaatg tatagttcgc cggcgacacc 1841461 ggaaggctgt acggctaaat gcggatctaa aacatacaaa cgcgcaccag gtacgggctt 1841521 cccaatcgga atccgcaaac ggtctctgtc ccgttctgga tctaacacgt aaaatgccgc 1841581 gtctaccgtg gcttctgtcg gcccgtagcc atggattaat gatacctgcg gcaatacaga 1841641 agcaaaacgg gctgccgtac gcggcgcaag cggttcacct ccggcgaata cacgctttag 1841701 gcttgtcctg tcactcagcc tttcgatttc cgcttgatcg agaaagctgt tcagcatagc 1841761 cggaataaaa tgagccgttg tcacgttttc ctgatgaatg gcttgtacga tcaatgcgga 1841821 gtctttttcc cagccgggcg gaagcagata cgccgaagca ccggaaagag cccaccaaaa 1841881 cagctgccac acagacgcat caaaggaaaa agaggttttc accatgacaa tgtcatcttc 1841941 cgaaagccga aactggtgct gcatgccggt cagaaaggaa acagcctggc ggtgctcaac 1842001 ggccactcct ttcggctgcc cggtagagcc cgatgtatag atgacatagg cgagagatcc 1842061 gtcgctaaca gaagcagaca catgacgttt tacttcttca cactcaagag atgtcatgtc 1842121 cacttcaagc gtttcgccag aaaagtttgg tgcggagcat cccggctgtg tcagcaagag 1842181 cgatgccccg ctgtctttca gcatgtagct cagccgctcc tttggatacg caggatcaag 1842241 cggcaaatac gcccctccgg ccttcaatac agcaaggaca gcgatcagca tgtcaggtga 1842301 gcgttcagac aggacaccga cgatactttc gtttgtgacg ccgcgtgccg caaggtgcgc 1842361 agccagccgg ctggcgtaca tatcaagctc agcgtatgtc agcgaaccgc ctgaaaagcg 1842421 aatggccagc cgctccggtg tgactgccgc ctgtcgttca aacagcccat gcagggttgg 1842481 ggcttcaggt gaaacagata ctgtcctgtt attttgagaa acgattttcc gtgttttgtc 1842541 ctcatctagc aacgtcatct ttgacacagg aagagatgga tcagagatga cgtcagagac 1842601 catgtgcagc aaataatctt ttatttcgga catcatgctt ggttgataag cgctggtctg 1842661 aaaatgaatc cgaacgtaca aggtacggcc tgggatcact ttgacactgc aactataatt 1842721 ggtcacctct tccatctcaa aatctttgac ggagaaatca aatgaccccg cttgattcag 1842781 ctcttcgatc tcttgctggg taggtgtatt ttcaaagacg ataatatgat cgatcaactc 1842841 ttgctttaga gcactctgcg cctgaatatc atacaaggga aagtaactat aggcttctgc 1842901 ctcattcatg tccttttgca ttctcctgac taggtcagaa aaagacagag aatcactttg 1842961 ggctcgaata ggaatggtat tgataaaaag cccgaccatg ttttccacat cttttagctc 1843021 agaaggtctg cctgatataa ctgaaccgaa cacagcatcg ctgctgcgat tgaccttttg 1843081 aagcataatc ccccataaag cttggaaaac agtgtttagt gtcgcaccag aagctgctgc 1843141 gattttctgt aattcggcgg tttctttttc gggaatggca aacgtgatct gctgtagtgt 1843201 cccattcgga atttgatctg ttcttttcgg caggggtgta gatttttcga aatgctgaag 1843261 cctctttttc cagtactcag ctgcttcttc acgatcttgc tgcatcagcc atttaatata 1843321 cgtcccgtac ggctgtacgg gaggcaaatc aggaagctgg cctttaccca gcgcttgata 1843381 aatatggaga aagtctttaa tgacgatgcc taaacaccag ccatccatta aaatatgatg 1843441 gtggctccag atacagacat aatgatcagg cgcccatttt aaaatagata ttctcatcag 1843501 tacatccgtt tggagatcaa agcctttgga tttgtcctgc tctttgaatg cctcggtaca 1843561 atgttcttta tccctttcat tgagatggga aatatcttca atatgaatag ggcaatgacg 1843621 ttgcttgagc acgacttgac gaggtttggc tacattttta tagatgaatg ctgttcgaaa 1843681 gatatcgtac ctgtcaaaaa cagcatccat acttttttgg aaacgctcca agtcaagctg 1843741 tccatggatc gtaaaagaag cctgttcaaa ataagctctc gactgttcat catacagtga 1843801 gtgaaaaagc atcccttcct gcataaatga caaagggtat atatcctgta tttcaggttg 1843861 ctgcggcatc agtgaatctc ctctcctata gtttgttgac ggctcccatg atctcactca 1843921 attcatcaag cgttaagtct tcatcagtga aatcagatgc gctccactct tggttttctt 1843981 tgccggtaca atgctcaatg atgttttcca gagtctgttt aaaatgcctg gaaaatgttt 1844041 ggattgtttt ttcctcaaat tgaaacctgt tatagatgat gtgcatgttc aggcaccccg 1844101 aagaaacggc gccgctgata tccagtgcat aaggacgctc ccagttcggg ctgatctcat 1844161 ttcctggctt gatgtcagac acctcaaagg catttgattg aatatcctga tcaaactggc 1844221 ctaaataatt aaagctgatt tctgggctgt ttttctgaga gccccatctt ttgctgatat 1844281 atttcagcac gccgtagccc gcgcctttat gcggtatacg gtgcagcata tcttttgtct 1844341 gtttaataag gtggcccagc cgctcttctt tgtccttatg atcggaatct ctcatatcaa 1844401 gccacacagg ataaatggag gtgaaccagc caacagttct gctaatatcg atgtcctcaa 1844461 gatatgattc ccttccatgg ccctccatgc tgattttaaa ttggttattt cccgtccatt 1844521 tctgcaaagc aagacctaaa gctgtcagaa ggatatcatt catctccgtg ctgtaagctt 1844581 tatgtgcagc cgttaatagt aattctgtgt gatggcgaga tagctcaaaa tcaatcactt 1844641 ctgtatcttt gaatgtgtta gatgctgcgt cattgtcttt tggaataggc tggatgtgac 1844701 ggttctcgca ctcatcccag tacgctgctt cgcgctgcac ctggcggctt atagagtagt 1844761 cagctattct ttgtgaatac gttaaatatg aatctgtttt ttgcggcagt ttaatagatt 1844821 ctcctgagac tgcctgtttg taagctgttg aaaaatcctc aaacaaaatg cgccaagaaa 1844881 ccgcatcaac aactaagtga tgaatcgtta gaaataaatg gtcaccattc tcggttctaa 1844941 acaatccagc gtgaagtaag gggccggttt ccaaacgaat atgttcttgc atccggctgg 1845001 ctgcttcctc aatcgtgttc cgggcttctg ttaggctatc ctttacatca aacagttcaa 1845061 gtgcatatag ctcctcatct gaaagatcta tccctctgtt tatctgcact tgcctgccat 1845121 cttcatgccg gcatacgatt ctcagtgcat catgatgagt cacaaggctt tttagtactt 1845181 ttctaagcgc agcctcatca aatcgttcag cccggtagat cataacggat tggttaaaat 1845241 gatggctttc cagagattgc gagaaaaacc actgctggat aggtgtccaa gtaatctcgc 1845301 cttcgaccgg gccttggtca atggcgcgta cgtcttttcg aacccgggcg gacagttcac 1845361 caagagtctg atgttcaaac atctcacgta ctgtcgtttc aaatccgcgc tgcttcagtc 1845421 tggcacaaac ctgcagcgct ttaatagagt ctccgccaag cttaaagaaa ttggcgctta 1845481 cacccagctc atctacatta agaagctctt cccaaatttc agccatcacc gtttcaatct 1845541 catttctagg actgatatca tcagctgtat aagcttgttt ttcaggctct ggcagggctt 1845601 tctgatcgag ctttccatta acagtcaccg ggatgctgtc aatttgtatc atacgggcag 1845661 gcagcataaa gtcaggcaag gcgtttttta ggtaagttcg gatgtctgat atattcgcag 1845721 cctgttgatc ttttatcacc atatatgcat atatagctgt ttgcccttgc tcgtctgctc 1845781 tggtaatgac agccgcctct ttaatcattg gatactgaag aagtgccgct tggatttcgc 1845841 ctaactcaat acggtgccct ctgactttca cctgctcatc aatgcggcct aagtattcca 1845901 gctcgccatt tgacaggcgc ttagcaagat ctcctgttcg gtataatctg tctcccggaa 1845961 gataaggatt ggatacaaaa cggtcagcgg tcagctcatc tctgttgaga tatccccgtg 1846021 ccacaccttc gccgcctata tacagctccc ctggaactcc ggtcggctgc aggttcatat 1846081 gggcatccat cacatgagcc tgcagagtag aaagaggccg gccgatattg cttttatttt 1846141 ttgcaatgtc tgctgcggac aattttttga atgttacatg gaccgttgtt tctgtaatac 1846201 cgtacatatt aatcaaatca gtatgaggat atttttcatt ccagctttga agcaatccgg 1846261 gctgtaaggc ttcgccgcca aaaatcacat agcggatgtt taaatgatct gtatgatttt 1846321 ggtcttcaag catcaagccg taaaaagcag tcggggtctg attgagtaca gtgacgcgct 1846381 ctttttttaa caataatcgg aatgcttggg ggtcacgggc tgtttcttta gagaccacga 1846441 ctaatgtact tccgttcaat aacgcaccga acatctccca tacagagaaa tcaaagcaat 1846501 aagaatgaaa taacgtccag acgtcttcat ggttaaattc aaaaggcagg ttttgatgct 1846561 tcaagagact gatcacattg cggtgctcga caatgactcc ctttggctga ccagtcgttc 1846621 cagatgtgta tatcacgtat gcgggctgat ccgttactat ttcttcaatg tttacatcag 1846681 ccggaattga gttgttttca cattcatcga tatacaaaat atgcccggtg tagtctgcag 1846741 gtttgtttag accgcgctct gtcagcagca gttttgctcc gctgtcattg agcataaagc 1846801 taatacgctc cttgggatat tcaggatcaa tcggcaaata ggccccgcca gcttttaaaa 1846861 tcgataaaac gccaatgatc atatcaggtg accgatcgag catcagaccg acgatatcgc 1846921 cagttctgac cccttgtttg atcagcatag cagctgcccg ctcggctttt tcattcaggt 1846981 ctcgatacgt aagctgagaa tggccgcaca ccactgcgat atgctccgga tactgagcta 1847041 cttgcttttc aaataagctt actatgtttt catttctcgg ataagctgca tactgcccca 1847101 ttttttcaag gagtaaccta cgctctgcag caggaagcaa ttgcatgttc gaaattctca 1847161 tctcagtatc cgccgttacc ccttttacca attcaataaa ataggatgcc cactgcgtaa 1847221 tggtttcttc ttcaaaaaga gcagtgctgt attcaaaacg gcagcgtatt ccactcagat 1847281 gctcctcagc atgtaatgtt aaatcgaatt tagatatatc atgtttagga gtgacagacg 1847341 aaatcgacag accaggcact tcgaaccgga aatcttcact gctttgaagc acaagcatcg 1847401 catcgaacag cgggttgcga tttacctctc gatttgtatc gagcttatct gccagctcct 1847461 caaaaggata atcctgatgc tcgtaagcgg tcagagccag gtggcgaatg tcatgcaaat 1847521 aggagctgaa cgttttgtgg ccctcgggct tgctgcgcat cgccaatgta ttgacgaaca 1847581 ttccgatgac gcgctccaga tcagcgtgcg gtcttccggc agcaggcgaa ccgacaacaa 1847641 tatcctcttg cccgcttagc ttagataaca aaatagaata gacagccaga agaatcatat 1847701 acaatgttgt tcccgtttca gccattaaac ggtgcagttc atcagccatg tctttatcaa 1847761 tgttgacttc aattgttcca cccctgaaat cagggagacg cggccttgtt ttatcaagcg 1847821 gtaattctag tgtaggaaga ctcccgccaa gctgaccgag ccagtaggcc tcctgttttt 1847881 tgtatagctc tttcgggtgc ttctcttgct gccaaacagc aaaatcctta taatgcaggt 1847941 ttaaagctgg caactctttt ccgcaatata agtcagtaaa ttcttggaca agagtgctca 1848001 tcgagacacc gtcggcaata atatggtgca tatcgagcag caaaaagccg cgattattgc 1848061 ccattgtaat gacacatgct ctaaaaagcg gaccggatga tagataaaac ggtttgataa 1848121 aggtctcgat tgcagactca agcatttgtt ctgattccat ttcaagctct tttagatcaa 1848181 aagccatctc tggataaatg atctgcacag gctcgtctct gtcaagcaca aaaacagtcc 1848241 gtaatgcttc atgccgattc acaagttctg tgagaacgct tctcaaccgc tggcgattca 1848301 gatttccgcg taattcaagt acagctggca tgttgtagcc tgtgctgtca tctgccagct 1848361 gatgaagagc atataatcgt ttttgcgaga aagacagcgg atagacatct ctttgatccg 1848421 caggttcaat ctgtgtaaaa gcgtgttctt ttaagctcat caatttgacc gccatgcttt 1848481 caaccgtcgg ataagaaaac acctcactga gcggcagctc gacattaagc tttttatgta 1848541 ttcttgatac cagtgcggcc gcttttaagg actgtccgcc taactgaaag aaatcatcac 1848601 gaatgccgat gtgctgttta ttcagcacat cttcccaaat atgtgcgaga tcagcttcga 1848661 ttaaggttcg gggcgccata tatgtgacac tcgtattgtt ttctggttca ggaagcgcaa 1848721 acctgtcaag cttgccgctg gatgttaatg gcatctggct gatgttgata atacttgctg 1848781 ggatcatata ggacggcaat gtcccggcaa gatgctgata caaatctggg aggctgtttc 1848841 ccttttccgg aacgatataa gcaacgagct ccttttcctc agcagaaaca tcacgggcca 1848901 gtaccgctgc ttcttttacc cccggtgctt gtcgaagaac tgtttcaatc tctctcagtt 1848961 caatacgata acccctaatt ttcacttgat catcaaaacg tccaatatat tcaatcgttc 1849021 catcaggcaa aaagcggcct gcatcacctg ttcggtataa acgctcccct tcaaggaatg 1849081 gatgatcgga gaatgctttc tgtgtcagct cttgctgttt gtagtatcct ctcgcaagac 1849141 ccgcgccgga aatacacagt tcacccgccg cgccgatcgg ctgcatttga tttccgtgca 1849201 aaacaaatac ttttgtgttt ctgatcgggt gtccgatcgt gatcctctct tttttattca 1849261 gatgccgcaa tattgttgtt gccacactgt tttctgtggg cccgtattca tttgccagtt 1849321 cagcagaagg acaaattatt tgattcaact caagcagatc aggcgtgacc gcttcacccg 1849381 caaatgtcac aatacgaaga ctttttgcat cgtcagcagt catcacttcc aataacaccc 1849441 tgtacaggga aggaacaatg atcatgtggc tgaccttata acgggctatt tttcgcttaa 1849501 gggccagcac atccttcgct tcgtcatctg ttgtcagcag tacgcacgca ccagataaaa 1849561 gcggggtaaa taagctcgtt acacagccgt caaacacgta cgaaaacaaa tggagggata 1849621 tatcctgttc ggtcatgcta tactcttccc gtctccattg caatgtattg gcaataccgt 1849681 gatgatcaac taaaacccct ttagggcgcc ccgtcgttcc cgacgtatag atcaagtagg 1849741 ctagatcacc tggcggcata tttggcgctt ctgtttggta actttctgta tgttctatcg 1849801 ttatcgtatt tccttcatag gacggaggga tcaaggaaat aaggtcttct tctatcagca 1849861 attgagccgc ttgactgtcc ttcagaagaa aagaaagacg ttctgctgga aaatgtggat 1849921 caagcggcat ataagcgccg cctgctttcc aaatcccaag cagagctgca ggcatttcca 1849981 ttgaccggcc catcattaca gcaacgatat ccccagatcc aacgcctttt tctatcaggg 1850041 cgtgcgcaat ctgattggct cttacttgta actggcgata ggtccagcac tcgtttccca 1850101 ttttcaatgc agcagcttca ggtgttttgt gagcttgttc ctcaaacaat tggggtatcg 1850161 ttttgttcac ataaggacgc tcagtttcgt taaacaattg gataacctgt tgctcctccg 1850221 gcggcacgat attgatgtca ctgacggcaa catcgggatt tgtcaaaatg caatccagtg 1850281 cttgctttag atgcccctga atcctcagca tctcctcccg ctcgtaaacg tctgcgttgt 1850341 agctgaattt gatataaaat gattctcccg gaacgataac gatattaaag tcgtaattgg 1850401 tttgttccga cattgaaatg tcactcagct tcagagcgcc ttcgtcattt tcactctcca 1850461 cgcttaatgc ctgatgaagc tgtacagggt aattttcaaa aacaaaaata tgatcgatca 1850521 acccttgctt caatggacta tggttttgaa tctcataaag cggataatac ccatgctgtt 1850581 cagatgataa aatatcctcc tgcacggctt tgaccagcga agaaaatgtt atgccttccg 1850641 cagatcggat tcgcactgga acagtattga taaacaaacc gaccattgat tcaatcccgt 1850701 caatcgctga cgggcgtccc gaaatgacgg agccaaaaac ggcatcatct gcagcattat 1850761 atcgatggag cagcacgccc caaatactca taaacagcgt gtttaatgtc actccccagt 1850821 tttgggcagc ctctgtcagt ttctcaacca tatccggcgc taatgaaaag ctgacctggt 1850881 cggctttata attcccgtct gccgtgcggc gctttattcg gggaatagaa gcagtattgc 1850941 cgtactcctt caaatattcg ctccagtagg cagcagtctc ttcttgatct tgttctccga 1851001 gccattcaat ataacggctg tacggcaccg tgctgccaag ctgtacaggt gagttatttt 1851061 tgagcgaatc atacatgctg aaaaactctt taagaataat gccgagacac cacccatcca 1851121 tgatgatatg gtgatgtgtc cagacacatg tatattggct gtctcctcta tcaaaaaggg 1851181 caagacgcat taaaggatct ttttgcaaat caaatccttt ttcccgatcc ttagtcataa 1851241 aagcatcaat cagcgtctgc tgttcttgat cagccaggcg agaaatatct tctctatata 1851301 ctgtcaattc acggtttgat agaactacct gctgcggacc tgtaagatct ggtacttctt 1851361 taatgaaaat cgttctgaaa atatcatatc tagaaacaag aaggtttaag ctcttttgaa 1851421 acgagtcgac gcatagattc cctgtgatcg taaacgaggt ctgttcgata tatgctttcg 1851481 agctgaaatc cattagtgaa tgaaacagca ttccttcctg catgtgcgat aacggataaa 1851541 tatcttgaat ttgtgccgat tgtgccatca attccacaca ccttttcaaa agttaaagat 1851601 ctttcacgag atcttcgatg ctagataatg cagacaacgt taattcttta ttgctgaaat 1851661 cgctcaatgt tttttcgcgt gcttttttct gcgaacaatg ctcaatcgtc tcgataagat 1851721 gcctgtgaaa acgatccata aagcactcaa ttgagtgttt gctgaacact tgggtgtata 1851781 ccgcttttac gtgaagccgt ccgtccgtaa tgagagcatt gatgtccagc tcatactctc 1851841 gttctctctc acccgctatt tcgtaacggg gctggtaata tgataattga aacgtttcaa 1851901 cttccttctc ttcgctaaat tgaccgagat aattaaagct gacctcaggc tctttatgcc 1851961 gcagttctcc tatgtgtgtt aacaatccgt atccagttcc tttgttcggt actcttctca 1852021 gcatatcttt tgtcgtctta attcggtatg cgagctgatc ctcgaaaggc tcgggaatac 1852081 ccatgtctag cagaatagga taaatggagg taaaccatcc aactgtcctt gaaatatcaa 1852141 tgtttggcac atgcccttct ctaccgtgtc cctcagtgct gatcacgatt tggtcatgcc 1852201 cagtccattc agaaagcgcc attcctaaag ccgtaagcaa aagttcgttg gcatcagtac 1852261 cataggcttg ctgggtttca aacagcaatt tttcagtcca gtccccggat agtacaaacg 1852321 ctgctgcgtc gctgttcatt tggagtttgt ctggcacatt ttctatgtcc ttaggaagaa 1852381 aagcagtgtg agcgtctaaa atcgtttgcc aatacgtttt ctctgaaagc aattgtttac 1852441 tttcagctat ttgggtaaga ccatcggcgt aggataaata agaatccgtt tttggcggta 1852501 attggatttc tttcttttct aaagcctgtt gatatgctgc agctaaatcc tcaagcagaa 1852561 ttctccaaga aacgccatct atcacaagat gatgaagtgc aatcagcaaa tgatcccctt 1852621 ctgccgtttt aaacaaacct gcttgcagta agggcccttt ttctacattc attttgcttt 1852681 gaatgacggt ttcctcagcg gcaagttttt catcaagatg agccctttcc agcgatgctt 1852741 ttgtccaatc tgaaatataa aggccaaaca gttcatgatc cttgtgattg attccgcgat 1852801 taaactgaat gacatggccg ttttggtcac gttggaaaat catgcgaatg gcatcatgat 1852861 gctcggttat tttacgcagc gctagatgaa gcgcgttagc attgaatcct ttttcactga 1852921 aaagcatgac ggactggttg taatgatagt gaaaagcatg tacctgtccg aaaaatcttc 1852981 gctgaatcgg ggtgagttca gcttcacctt ccgcaggtcc ctggtccgct tgagatgcca 1853041 atggtgtgat atgtccgcat agttcctgaa tcgttgaata acggaataag tcgcgtattg 1853101 tcatgctcca gccttcagct gccagacgtg ctgccacttg taatgcttta attgagtctc 1853161 cgccaagctc aaaaaaggaa tcgtgaatgc cgactcgtga catgctcagt acatcttccc 1853221 atatatacgc catcgttttt tgtaagtcgt taactggtgc ggtatatgga cgcgataaca 1853281 cattatttgg agccggcaag gcatttctgt ccagctttcc gtttagggtc agcggcatgt 1853341 ttactaaagg aatcagatat gcaggaatca tatacgctgg cagttccttt gttaaagcag 1853401 cacggagagc attcgtattg acgtctgaag gcacaatata tgctgccaaa ccagcctgtc 1853461 catttttatc atgctgaacg gcaacagcag cttctctgac aagccccgtt tgaagcagaa 1853521 cactttcaat ttcttctgtt tcaattctgt atccatttat ctttacttga taatccattc 1853581 ggccaagaag ccggatcgtt ccgtttggaa gccagcatgc tcgatcaccg gttctgtaca 1853641 gcctttctcc agagacaaat ggattttctg taaatttcat ttgcgttaag tcaggtttat 1853701 gatgatagcc tttcgcaaca cctgccccgc cgatgcacag ctcgccggca acaccgatcg 1853761 gctgaatttg atcagtctgg ctgagtacgt acatgtgtac attcggcagc gggctgccga 1853821 ttggtacgtt atctcccgta cactctccac ccatactggt ttcatagaaa ctcgaatcaa 1853881 tggttgcctc tgtgacacca tagctattaa tgatgcgcat gctttggcca aagcgatctg 1853941 tcaatgtttt gaaatcttga gctttcacca tgtcggaacc aagaatcagt atgtctaagt 1854001 caggaagctt gaactggtta cggtatacat actccatcac cgggataatg agagccggtg 1854061 tcgactccat caccgtgatt ctctgagatt taatgatttt atatatttca gcaggttcca 1854121 gccgtgtttc atctgggcaa acgattagag tcccgccgtt ggtcaatgtt ctcgccaaat 1854181 ctcctgagaa gacatcgaat gaaaagctcg cgatttgaag cagtctgaca ggcttccgat 1854241 ccagttcata aatttgacgc caagcaagag cagcatgagt aaagttctga taggtgacaa 1854301 taacaccttt aggcgcaccc gtcgttcctg acgtataaat gatatatacc ggctcttcag 1854361 gagcaggaga taagttaagg ttgcagttac tttcttcaaa agagccctca tcgtcaagga 1854421 agatgtgaga catctcagat tcaggcgagt tcgaaatcaa atgcttcaac tctctctgta 1854481 aaagaagaat atctgccccg ctatcacgaa gaatgtattc aatacgagct tttggataat 1854541 gtgcatcgat tgggatatac actccgccag ctttcatcac tgccagaact ccaacaattg 1854601 catcgatgga ccgcttggct aaaacagcca cagttggctt cggtcctttt ctgttttgca 1854661 atgttcgtgc cagacgattg gctctttcat ttagaaggcg atagctaatc tctgtttcgt 1854721 tatcaataac agctatatgt tctggatttt cttcagcttt cgcttcaaat atgcgatgaa 1854781 aaggaatatc tttttgagca aattcaactt gagttttgtt aaattcaaag actatttttt 1854841 gtttttcttt atcactaagt atgtttattt gtgcaaggct tgtttcagga gttgaaagtg 1854901 cctcatgcag aaattcgata aaatgatcag cccagcgttc aatcgtagct ttcaggaata 1854961 cttctgtact aaattccatt tcgcagcaaa tagatccact tatttccgta gctattaatg 1855021 tgatatcaaa taaggaaatg tgatgtgcga aattggcagg ccggactttt atttctctca 1855081 gatctatgtc ttgtttttcc acattttgaa ggataaacat cgcatcaaac actgggttcc 1855141 ggctcatatc tcgtgtcaat tcaagcttat cgacaagctc ttcgaacggg taatcctggt 1855201 gctcaaaggc ttccaatgct gtctcacgca cttcctgcaa atactgtacg aatggcttcc 1855261 cgccctccgg gcgcgtccga agcgccagcg tgttcacaaa catgccgagt atcggctcaa 1855321 gatccttgtg cggccggccg gcaattggcg agccgacgat gatatcttcc tgtccgctta 1855381 agcgtgacaa gaacgcggtg taagccgcaa gaagcaccat gtacagtgtg cttccgtttt 1855441 cacgtgccag cttgtgaagg cctgatgcaa cctcttgatc cagcgtaaat gagaccttgt 1855501 cacccgcgaa gcttcgcacc ggcgggcggg catgatcagc cggaagatcc agcacaggca 1855561 gctcgccctc gagctgcttc agccagtacg cctcttgcgt tttgtacgcg tctcctgttt 1855621 tgaatccttc tcgccatacg gcataatctt tatattgaat gcgcagtgcc ggaagattcc 1855681 gattattgta cagctcgccg aattcccgaa tcagaatgtt gacggaaaca ccgtctgaaa 1855741 tgatgtgatg catatcaacc agcaacaggt gccgctcatc tgatatcttt acgatttggg 1855801 cacggaacag cggcgcttgg ctgagatcaa acggtttgat aaatgcggct gcggcctcct 1855861 gttcggttcg ttcgccgaga actgtagtct gtaacgtaaa cggcacctcg tcatggatgc 1855921 gctgcaccgg atcgcctcct gcgtcctgtt cgaaggaggt ccgaagcgac tcgtggcgct 1855981 tgatcagctc tttgaaagct ctctccatcc tttcagggtt gagcttccct tcgagctcta 1856041 acacagccgg catattgtag cctgtccctc cgtcctccag ctgctgaagg acataaatcc 1856101 gcttttgggc agaggaaacc ggataggttt cctgtttttc agcgggctta atcgcttcat 1856161 atggactgtc cgttccttca cggataacgg tagccagtcc ttctactgtc ggatgggcaa 1856221 acacatcttt tagcggcacc tgtacatcga attctttggc gatccgtgag acaagcgccg 1856281 ttgcttttaa ggaatgtccc ccgcggtcaa aaaagttgtc gtgaatcccg acagggccat 1856341 ttttcagcac gtcctcccac agctgagaaa gcttcatctc agtcacgttt ctcggcgccg 1856401 tgtaggtctc cgcatctgcc gctccgccag gagctggcag ggcgtttcgg tcgagctttc 1856461 cgcttggcgt aaccggccac tgttccatct ctatcatata ggctgggacc atgtagcccg 1856521 gcaacagtct ctcaagctgt gcacgcactt cgtttctttg gagcccttct acataagcgc 1856581 ataattccgg ctccccgctg tctgtccgta cggtaacagc cgcctctctt acgccttcta 1856641 tgcttcttag tgccgcttca atttctcccg gctcaatccg gtagccgcgg atttttacct 1856701 gatcatccgt gcgcccgagg aattcaacat tcccgtcagg gagccagcgc gccacatccc 1856761 cggttttgta catgcgttcc cccgggtaaa acgggtcttc aagaaaacgc tcctccgtta 1856821 atgccggccg attcaaataa cctctggcaa cacccgctcc ggcaatgtac agttcgccgg 1856881 cgacaccgga aggctgtacg gctaaatgcg gatctaaaac atacaaacgc gcaccaggta 1856941 cgggcttccc aatcggaatc cgcaaacgat ccctgtcccg ttctggatcc aatacgtaaa 1857001 atgccgcgtc taccgttgct tctgtcggcc cgtaaccatg gattaatgat acctgcggca 1857061 atacagaagc aaaacgggct gccgtacgcg gcgcaagcgg ttcacctccg gcgaatacac 1857121 gctttaggct tgtcctgtca ctcagccttt cgatttccgc ttgatcgaga aagctgttca 1857181 gcatagccgg aataaaatga gccgttgtca cgttttcctg atgaatggct tgtacgatca 1857241 atgcggagtc tttctcccag ccgggcggaa gcagatacgc cgaagcaccg gaaagcgacc 1857301 accaaaacag ctgccacaca gacgcatcaa aggaaaaaga ggttttcacc atgacaatgt 1857361 catcttccga aagcggaaac tggtgctgca tgccggtcag aaaggaaaca gcctgacggt 1857421 gctcaacggc cactcctttc ggctgcccgg tagagcccga tgtatagatg acataggcga 1857481 gagatccgcc gtcagcagga gtaaactcat ggttttctgc tttttcgctc gcaagagatg 1857541 tcatgtccac ttcaagcgtt tcgccagaaa agtttggtgc ggagcatccc ggctgtgtca 1857601 gcaagagcga tgccccgctg tctttcagca tgtagctcag ccgctccttt ggatacgcag 1857661 gatcaagcgg caaatacgcc ccgccggcct tcaatacagc aaggacagcg atcagcatgt 1857721 caggtgagcg ttcagacagg acaccgacga tactttcgtt tgtgacgccg cgtgccgcaa 1857781 ggtgcgcagc cagccggctg gcgtacatat caagctcagc gtatgtcagc gaaccgcctg 1857841 aaaagcgaat ggccagccgc tccggtgtga aagctgcctg tcgctcaaac agcccatgca 1857901 gggtgaaagc tttaggcgaa acagcttccg tcttgttaaa ctcatacaac aatttttgct 1857961 tttctcttgt attcgtcata tctaattctc ttataaagct gtgcggatgt ttaagggcgt 1858021 tttccagtat ggtaagcaga tgagattgta ttcgtttaat atcctcaaga gaaaacaagg 1858081 tattttgata gtcgaaattt aattgaatgg ttccattgtc tatccgttct tgtatttgaa 1858141 ctgaaagttc gttcgcggtg tatccgctga aataaagcgc tgtttcatag tcaaaatcat 1858201 ctgcattgtg ccactgaagt ggctgatact gcatagatat accgataagg ttgtgtaaat 1858261 ccttctgttc atttcttaat tcatttacaa gcaaattata aggaaaccgt tgatgacgca 1858321 taacagaaag ctgttccctg cctattgtgc ggacaaagga aagaaaatct gtgtcaggat 1858381 caaccgttat tctgattgga agggaactaa cgaacatgcc gagcatttct ttttcagcct 1858441 ttgaacctct gttgccatag taggtgccaa tggcaagatc ttttttagaa gtgattcggc 1858501 tgatgcatat gtaaaatgaa gccataaata aggaaatgat attgatcttg tgttcttcgc 1858561 agaagattcg aatcgtttgc tctagatcag gtgaaagaat gatggtgtct ctggatgcag 1858621 atgtgctctg tttttgtaag gacgtctggt cggctaacga gtggtattcc aacgggtgct 1858681 caaaggtttg cgtccaaaat aaacggtcct ttgcaaaccg tggagattgt agatattgac 1858741 tctctttttc gatgtagctc aagtaagaag gttccggctg atcaggtaaa ggatctttct 1858801 ttttcatttt ttgataaaga tctataattt gatttcccat cacatttaaa gagattccat 1858861 ccattatgat atgatggaat ttcgcaaata gccaaacttc atgagagtca attctaagga 1858921 ggtaaaattg aaaaagaggc gagttgaaca gtttaaatgg aatgctcgct tgatcctgaa 1858981 tccattgctc tatttctatc atttcaacat ttgaaaaatc aattattcta agtggataat 1859041 atttatattc agtaaggtgc aatcgaggct caagctcttc tccttctaac agctgaaatc 1859101 taatggcgtc gttgcgggag atggaatgat tcagtgctcc ctccagagta tcaagctcaa 1859161 tattgccttt aaatttcaca caagctgtaa gattgcaaat gctggtatct ggctccagca 1859221 gttcggtaaa ccacactctc ctttgggcat gggttaaaga ataagtatgt tcgctcaacg 1859281 gattccctcc agttctcata ataagaggat aagaaaatgt agaaaaaagc agaaaaatga 1859341 caataaaaga aattatatga ctatataatc catatatgca ctatattaac ggatattttt 1859401 taaagtacaa taaaaaacat taaattttta taacattttt tttgaatata gtattatttc 1859461 tttatttttc gtttcttttt ttatcaaatt tccggatata aagtgataaa agtattgttt 1859521 tacataaggt cttatacact actttttaat cggactaatt ttcttttgtg catcattctt 1859581 ctaattgttg gaaggttcga caaagcgtta ttacagacat aaaaaaacct gttttctctt 1859641 ggaaaacagg tctcccgcta ttattgattt gccaaaatga cagcgatttg atcctcaata 1859701 tcttttccat cctcttcatc aatcaatcca tttagaagaa tagagaaaac aagttttttt 1859761 ccgctctttg tttctgcgta ccccgataga gagcttaccg tactgagcga tccggttttt 1859821 gctcttactt ttccttgtgc aggagtgcct ttcatgcggt ttctcagcgt tccgcccacc 1859881 attctgtcag gattccccgc aacaggtaaa gaatttagat aagccgagaa ccaactctga 1859941 tcctgaatgt catataacag ctgtgaaagt tgatctgagg atacagcatc aatatgtgag 1860001 attcctgatc cgtcccttaa gacgagtgat ttagaatcaa caccaaattc cggaagcgta 1860061 ctgtttaaca cttcgagccc cttttcccag ctcccttctc cttttttcac tttccccatc 1860121 tcttttacga gcacttcggc atgtccgtta ttacttaatt tcatgaacgg cacaaaaagt 1860181 ttcgataaag gcattgagcg atgagagagc agcacatctg aagaactagg tgcttcaccc 1860241 gtcttgatgt cccctttcac agtaatacct tgttttttta gtgactgctt aaataaatct 1860301 aaggcatatc cggcaggctc ccagacagaa atccattcct ttgtcttgtt tgcgtcaacc 1860361 ggtacgctcc cttcaattgt aatcgtgttt gttccatgct ctctttcgat tgtgaggtct 1860421 ttctctgaac cggcagcagt cgttttagca tcgttcttta tcgttatata atcggttttc 1860481 ggagagacag acacggcagg ctcttcccct tctttttgat ttggggtgac ctcaacaatc 1860541 acagtgcctg catcatagtc ttcgtttgga gacgctgtta gagcggagat tggcgcgcca 1860601 taatatgtgt attcatcgct ccaaggcata tcaggtgata atcgcatgtc atcatgccac 1860661 gtatcatcac cgatcagatt gcctttaatt acttttacgc cggaatgttt caatatctca 1860721 gccattttgt caaaatcaga tggtaaaagt gtcggatcgc ctttcccttt caaataaagg 1860781 ttaccattca gctttttccc tttcagtgtt ccatccgtcc ggacctcggt tgtaaaagaa 1860841 tagttctcgc caaggacaga aagtgccgcg gccgctgtca aaagctttag agaagaggca 1860901 ggcctcattc gggtgtctcc tgaatgttca tatagaacag cacctgtttc cgcagagcga 1860961 acggtgatgc cggccattgc gccttcgagg gcaggatgat cagctaaaat cttatcgatc 1861021 tgcccggaaa gtgcatcttg tttttcagcg gcaagcgcag cctgatgcat ataaggcacc 1861081 gaagcaacga cgaaaagcag taaaacagca acataaagct ttatgctttt tttcattaat 1861141 ttccccgcct ctctgcgctt catcattggc tattgatgat tcagttcaat ggtgatactg 1861201 cttttagctg tcgtttcttc tcccggctcc agcacttgta aaccagtgag tgacgaaggt 1861261 aaatcaagat tcactgcgtt tgtcacccat gtgtaaggct cagggcataa atacccttgt 1861321 tttccgtccg cattgtatac aacccaatgt ttaaactgtt catctgcctt ataaataatg 1861381 ctgatatgtg catgctgatg ataaatgact gcctggtttt ctccgcccct cttctgataa 1861441 gaagataaaa agacatcatc cagctgcttg tggcgcaaat ccattccttc atgcaaagct 1861501 tctttatacg ggacatccat cagcttcccg gtcggcagca ggcgttcatc caactcccat 1861561 tgctgatctg ctgtcaggga gaataacgag ctttctgccg gaaatataaa tgtagtatga 1861621 taaccaattc cccaaggaaa cgcttccttt cctttgttca tgaccgtcgc atgtttaaat 1861681 agggtattct ccttgatcgt gtatgtcatc cgaacgacgg catgatgagg aaattgcttc 1861741 tgcacatggg gaagctcaga aagatcaatt tctgtttcaa caatcactcc ttcatcagtt 1861801 tgcttcgtgg tcacgacatt ccacttttca tggtaaagaa acccgtgaag atggttgtgt 1861861 ttatccttct cgttgatatc aaaatgatac gttctgcccc ggaaactgaa tgtaccgtca 1861921 cttatgcggt taggcgggaa caggattgga atgccataca atgttggtgt gtcgtgaaaa 1861981 ctttctgctg tttccggttc acgcaaaagc tggacatttg ttgttttgtc cacgagagaa 1862041 atgacgttgc tcccccactc agggacaaca atcatttcta gatgttcgtt gcccgctttg 1862101 atggccggcg ttcccaaata cgtgattttc tcaataaagt ttgccatgtt tactcaacct 1862161 ctccttgatt cattgctagt ataagaattc aatgtactgt accatatttc ctccatttta 1862221 tattttcccc tatcaaataa aaaaacaccg ttcaaactta tgaacggtgt gattcggagg 1862281 ctattggatg agacgtgtga tttgtttctt tttccagacg aattgataat acccataaat 1862341 caacagcaag ctgacggcaa acgcagctgg ataaccaacc cagacgccga gtatttcaag 1862401 ctttgtatag tgagaaagga cgaaagcgac aggcacctct actccccaga ttgcaaaaat 1862461 actgatgacg gtcggccata aaactgttcc gcttgcccgc atcgttgcag aaataatttg 1862521 ggcatttcca aacagcaaat agctccacag tgtaatcatc aaaagacggt gcgcaatgta 1862581 aagcgtctct tgctcggtta aaaataacga taaaatctga tgtgaaaaaa catagatcag 1862641 aatgatcagt acgccgccaa tgatataatt cagccaaatc ccaacgcgaa tgacctgctt 1862701 taagcggtca aactcgtttg ctccgatcga ttgcgcagcg aaaatagaaa ccgcaatacc 1862761 aaggctgacg gccggcatct gtacatagct ggccacctgg ttgaccactc cgtatgcagc 1862821 tgttgcatta gagccgtaat gattgacgaa tgaaataacc gctatctctg ataatgagac 1862881 aagaatcata ttgatgcttg ctgggacccc aagacgcagc aggagaacca gcagttcctt 1862941 atccattttc aaataacgac gcactgtttt atcaaattgc agcgggtgtt ttcgctttcg 1863001 taaatacacc attaacacga gaaaagtcgc aatcgtggaa atgacagttg catatgccga 1863061 gccgtatatg cccagtttcg gaaaaccaaa catgccaagg attaaaacag gcaaaagcgc 1863121 gatgttgatg accgtgctca caatcagcgt ataaaacggt gtcttggaat ctcctgttcc 1863181 gcgcaaaaag gtagtatatg caaaatataa aaacataaac ggcatagcat aaaataaaat 1863241 acgtgcatag ttagcgctga catgaatgac attttcaggt gttcccatta aacgaaggat 1863301 atccagggtg aaaatactgc cgataacggc taacacaacg cctaataaaa atgtaaacgt 1863361 gagtgtcgtc ccgacaacag cctttagccg ttcctcattt ttcgctccgt aagcttgtcc 1863421 tatcagaatc gaacttcctg aaccgatccc aatcgtaaat gagattaaaa gaaaaaataa 1863481 cgggaaaaag gatgatacag ctgccactgc atcaacaccg agccatctgc ctacagccat 1863541 catcccgact agctggccga ctgattgcag cacattgctc agcagaagcg gcactaaaaa 1863601 gagtgacatc gaccgccaaa ctgatggttt gcttttcttt tgagttacaa gaggttcttg 1863661 tgatgtttcc atattaaagg actcctttat ttgaaatcgt ttttaaacat gccctcattt 1863721 tttgacaaaa acaggatatg taacatgtta ttattcatca ctgcacttat gaaacccttc 1863781 ccgattcttc taattttaca catcttttta gcttatgaag aataaactag caagtaatgg 1863841 cgtatttttt gtgagtaaaa gaataaaaaa taatttatgc aaaagtattg taatctatcc 1863901 gtaattattg taacatttgt aacataagag aaagagattt tgaaggagag agcgataatg 1863961 aaaaaatgtc ttctatttct aacaaccatt gcacttattc tgtcattaag cacaaatgca 1864021 tttgcgaaaa atacatcagg cgatttatca caaaaacaag cattacagtt ggcattatcc 1864081 gctagagaac atttttggaa caccatgagc ggccacaatc cgaaggtgaa aaaagcagtt 1864141 tgcccatcag gcacattcga gtatcaaaat cttcaatatg tatacatgtg cagtgatcta 1864201 ggcactaaag caaaagcggt gaattattta actcctattt ttacaaaaac agcaatcgaa 1864261 aaaggcttta aagattatca tttcactgtt tcaaaaggaa aacttgctgt tccaatcggt 1864321 gacggagaca atcttttgaa ttggaaaaaa tcaactgcta aactgatctc taaaaaaggc 1864381 agcacaatca catacgaatt tactgtccct acattagacg gatccccttc tgcaaaacgg 1864441 aaagtgacat ttgtgaaaga aaataaaaaa tggaaagtca atcaatttga cgcagttata 1864501 taagaaaaac gcccggtata agcgggcgtt ttttatttgg tttgcataaa gaaagacaac 1864561 aggcgaaaag tgcctgttgt ctttttgtga atataacgct ctaggagaga ttcgaactcc 1864621 cgacctgcag tttaggaaac tgctgcacta tccgctgtgc tactagagct tttggtattt 1864681 atatagtagc tctgatgatc aatattttca agcgatttgt attaaagccc tccaaaaacc 1864741 ttatatgcgg ctcttgtcgt atcttcatca ataccgatat accgcattgt aattgatggt 1864801 gatgaatgat tcagtattct ctgcagctcg gcgatgtctt tcgttcgctg ataaaaatga 1864861 tagccaaacg ttttccggag tgtatgcgtc cctatctcct caagtccgca cgctgcagcg 1864921 gcctctctta aaattctgta ggcctgaatg cgggaaatcg gcttcctggt ccgcactgat 1864981 ttaaaaagat attcgttttc cttcatgtct ttcgtatact cgtatatttc ctgtttcagc 1865041 gattctaaaa taagaatctt tcttttcttt ttcgttttgc tttcagtcgc ccataaatga 1865101 tctttatttt gaacgtcctt cacttgcagc ggcagaatat cagaaatacg gagcgcgctg 1865161 ttgatgccga aaataaacag aaaataatcc cgcttgtttt tgttaagcaa atactgtttg 1865221 acttcttgga ttttctctag actgcgaatc ggctgtacaa tatgcatcaa aaaactcctt 1865281 aaaaaccgtt atgtaacatt ttgaggtcta tgttactatt atagctgaaa aacgttgaat 1865341 gtcaaagtgc ggcggcgttt atgtaacata atatacatag tgttacataa gcttttaaaa 1865401 aagcttcttc caaccttcac cctataaaat aagctttaaa gcctcttata aagcttttaa 1865461 cctcttggat acttatcccc ctactaatca tcaaaaaacc tcttaaaatg aaatctgaca 1865521 ctcccaattt tctggagctt ccgcaaaaat atacaaaaaa agacacaatt tcaaattgtg 1865581 tcctaatcct catcctttac atcaatatct tccgggatcg gttcatttaa tatttcctgc 1865641 acaagtgctt tgtaattctc cagctgttcg agatgcgttt tgaactgttc cttataaatc 1865701 aaaaattgct ccccgtcatg aacggctctg attttccctt cgagcaccaa gcttttaata 1865761 taatcctctg aaagatttgt atattctgct gtttcttcaa tcgttaaata catatagcag 1865821 tcccttctta atccgtatgc tgattctaat atagcacatg gctcatatca atataatcaa 1865881 ttctgcacag aaaaacggca ttatgcacta tataatatac catttgtcac ttgtgaaaac 1865941 gctgtaattt ttttacgcta agattgtaac aatacagctt catataggag ggagaacatg 1866001 aaaagaacgt ggaacgtctg tttaacagct ctgcttagtg ttctgttagt cgctggaagt 1866061 gtcccttttc acgcggaagc taaaaaaccg cccaaaagct acgatgagta caaacaagta 1866121 gatgttggaa aagacggcat ggttgcgacc gcacatcctc ttgcttctga aatcggtgct 1866181 gatgtgctga aaaaaggagg aaatgctatt gacgcagcgg ttgccattca atttgcactc 1866241 aatgtaacag agccgatgat gtcaggtatt ggcggcggcg gttttatgat ggtgtatgac 1866301 ggaaaaacga aggatacaac gataatcgac agccgtgagc gtgctccagc aggcgcaact 1866361 cctgatatgt ttctggacga aaacggcaaa gcaattcctt tctctgaacg tgtaacaaaa 1866421 ggtactgccg ttggtgttcc aggcactctg aaagggctgg aagaagcctt ggataaatgg 1866481 ggaacccgtt cgatgaagca attaattacc ccttctatta aactcgctga aaaaggcttt 1866541 ccgattgatt cggtgttggc agaggccatt tctgattatc aggaaaagct ttcacggact 1866601 gccgcaaaag atgtattttt accaaatggc gaaccgctta aagaaggaga tacccttatt 1866661 caaaaggatt tggctaaaac atttaagctt attcgctcca aaggcactga cgctttttat 1866721 aaaggaaaat tcgccaagac gctttctgac actgtccagg atttcggcgg atcaatgaca 1866781 gaaaaagatt tagaaaatta cgacattaca attgatgaac cgatttgggg agattatcaa 1866841 ggctatcaaa tcgctactac tcctcctcca agctccggcg gtattttctt attgcaaatg 1866901 ctgaaaatcc ttgatcattt taacctttca caatacgatg tccgctcatg ggaaaaatat 1866961 cagctgcttg ctgaaacgat gcatttgtca tatgccgacc gtgcgtctta cgcaggtgat 1867021 cccgaatttg taaatgttcc tctcaaaggc ctgcttcacc ccgattatat taaagaacgc 1867081 cagcaattaa tcaacctaga tcaagtgaat aaaaaaccga aagccggtga cccttggaaa 1867141 taccaagaag gatcagcaaa ctataaacaa gttgaacagc cgaaagacaa agtagaaggc 1867201 caaacaaccc actttacagt tgctgaccgt tggggaaatg ttgtttctta tacaacaaca 1867261 atcgaacagc tattcggaac gggtattatg gtccctgatt acggtgttat tttaaacaat 1867321 gaattaacgg attttgatgc gataccaggc ggagctaacg aagtacagcc aaacaaacgg 1867381 cctttaagca gcatgacccc gacgatttta tttaaggatg acaagcctgt cctcacggtt 1867441 ggatctcctg gcggggccac aattatttca tccgttttgc aaaccattct ctaccacatt 1867501 gaatatggta tggaattaaa agcagctgtt gaagagccga gaatttacac aaacagcatg 1867561 agctcttacc gttacgaaga cggagttcct aaagatgtcc tcagcaagct aaacggcatg 1867621 ggccacaaat tcggcacaag tccggtggat atcggaaacg tgcaaagtat atcgatcgac 1867681 catgaaaacg gcacctttaa aggtgtagct gattcaagca gaaacggcgc ggcgatcggc 1867741 attaatttaa aacgtaaata aataaaaaac tgtactcgct tcaaatgagt acagtttttt 1867801 catgcagatc tttaaaataa aaactgacaa acgtctttat tctgctaatg cacgtctatc 1867861 ttcatctttt catttcgttt atctcatcaa gaaatgtctg aaacgcactc gtaataaaaa 1867921 agtctttcct gtatataaag acgatctcta agtcttgata tgatggtggc agctgatgaa 1867981 tccatacatt tgtacgatgc tcggagccgt caacagcgga ctttgggagc agcgccgtac 1868041 ccatcccggc ggaaacacct tttataatag cctccaatgt gccaaactct atgatttttt 1868101 gattgtgtat gcctgcttcc tctagtaatc ttttgaccct gtcacgatga gaacagccag 1868161 ccccaaaaaa gagcatcggc tgctgaagca tgtcttctgc cgtcccttct cgtgatgaaa 1868221 tcaaaactaa ttcatcatgg gagacatgga gttgtctaac tgcagcgtgt tcaaccggcc 1868281 catatacaaa agcgccatca actttatgat caagaacctg ttgaatcaaa tgatgcgtat 1868341 cagctgtgtt cactgataaa tccacttcag gaaaacgcct gaggaaggat gctgcatgct 1868401 caggcagatg cgttaccgcc attgtttcca gtgatccgat ccgcaaaggc ccttttggtt 1868461 gcctgctcat tcgggtcgat ttttcagctt ggtctaacag cgataatact tgatctgcat 1868521 attgtaaaag attttctcct gcagcagtca gcttcattcc ccgattcgtt cgatgaaaaa 1868581 gcctgatatt caaatcttcc tcaaggttat gcactctggc tgtcacattc gactgaacat 1868641 aattcagcat ttgggctgct ttcgttatgc ttccttcgcg agcaacagcc tgaaaaatct 1868701 ttaaatctcc gctttccacg cgctctcacc tgcttgctat gatgaaaagt gatattggct 1868761 atcatatttg ttcattttac tcgaagaaaa ccgctatgta aaatatgtaa agatatgaaa 1868821 atacaattaa tgaggaggca gacagcatga aagctgtaat tcacaacgga aaagccggtc 1868881 ttctggggtt atcagttcag gacgttccat caacaaagcc tggatacgga gaggtaaagg 1868941 ttaaattaaa atctgcaggc ctgaatcatc gtgacttgtt tcttatgaaa aacaaatctg 1869001 aacaagatcc tcacatgata ctgggttctg acggcgcggg tatcatcgaa gagattggtg 1869061 aaggcgtgaa aaatgttact gttcagacag aagtagtcat tttcccgaca ttgaactggg 1869121 atttgacaga aaatgttcca cctgtacctg agattctggg aggtccttcg gacggaacac 1869181 ttgctgaata tgtgatcatt ccttcacaaa atgcaatcaa aaaacctgct tatttatctt 1869241 gggaagaagc gggcgtttta cctttatccg ctttaactgc atatcgggct ctgtttacaa 1869301 aggggcaatt aaaaaaaggc gagcatctat tgatacccgg catcggcagc ggtgtagcaa 1869361 cctacgcttt atttatggct aaggcgattg gggcaacagt aagcgtgacc tcccgcagtg 1869421 aggagaaaag aaaaaaggcg ctgaaattag gtgctgatta cgcatttgac agctacagca 1869481 attgggatga gcagttgcag ggaaaaaaga tagatgttgt tcttgacagc ataggacctg 1869541 ccctcttttc ggaatacttc cgccatgtaa aaccaaatgg ccgtattgtc agctttgggg 1869601 caagctcagg ggataatctc agttttccgg tgcgttcttt attctttcct caggtcaatg 1869661 ttttgggaac ctcgatggga agcggtgagg aatttcaagc tatgctcgct ttcattgaca 1869721 aacataagct gcggcctgta attgaccgga tatatccttt agaaaaagca tgtgaagcat 1869781 ataaaagaat gcaggaaggc agacagtttg gaaacatcgg gatcgtaatg gaataaaaaa 1869841 agaaaccggc tggcagccag accggtttct cttatatgat aatccccttt atttacggaa 1869901 gaactgaact ccccatcaaa tatcgatcca cttcacgcgc cacttcacgg ccttcattaa 1869961 tcgcccatac gattaagctt tgccctcttc ttgcatcccc tgcggcgaat acaccatcga 1870021 tatttgtttg ataatcccca tatgctgcac tgattttgtt atttactgaa ttaacaccga 1870081 actgtttcaa cagcggctgt tctgtgcctt caaagccgat agcgataaag acaagctgag 1870141 caggccatac tttttccgtt ccaggcagct cgcggaactc gtattttcca tgctcatttt 1870201 tcactttttc catttggatg gtatgaagct ctttcagctt tccgttttta tccgcgacca 1870261 tttttgtcgt ttgaatggag tattctctcg gatctcttcc gaattttgct tctgcttcct 1870321 cgtatgcata ttcaagcgta aagacgtgtg gctgttcagg ccacatattg tcattcgtgc 1870381 gggctggcgg aagtttcggg tgtttgccga attggtgcac gcttttggct ttttgacgca 1870441 gagcggtagc cacacagtca gctcctgtat ctccgcctcc gattacgatg acatctttcc 1870501 ctttggcatc aatgaattgc ttgtctttaa aattagaatc taaatagctt tttgttgcaa 1870561 gtgtgaggta gtccattgcg taatggactc cttttgagtc gcgtccttcg attaagaggt 1870621 cccgctgttt ttgagcgcct gtgcataaga tcacagcatc aaattgctcc tttagctcat 1870681 cagctgtaat gtcaacaccg atttctgtgt tcgtgacaaa atcaattccc tcttgcgtca 1870741 gcaatttaat tcggcgttct acaatgccct tctcaagctt catgtttgga atgccgtatg 1870801 ttaaaaggcc gcccgctctg tctgctcgtt caaaaacagt gacggaatgt cccgcttgat 1870861 tcagctggtc agcactcgcc agtccggctg ggcctgaccc gacgatggcc acttttttgc 1870921 ctgttcgttt ttttggaatt ctaggttgaa tccagccgtt ctcaaatcct ttatcgataa 1870981 tggtccgctc gatgttttta attgatacgg ccggatctga aatcgctaaa gtgcatgatc 1871041 cttcacaagg agcggggcat acccgccctg tgaattcagg aaagttgttt gttttcaaca 1871101 gacgttccaa tgcttccttc catctgcccc ggtagacaag atcattccat tcaggaatta 1871161 agttgtaaat cggacagccg gatgtaaatc cgttaatgtc cgcaccgatc tggcaaaacg 1871221 gtgtaccgca atccatacac cgcgcccctt gccgtttcga tgcttcttct gaaaaaggag 1871281 cagaatattc tttccaatcc tttaagcgag tgagagggtc ccgctccgca ggtttttctc 1871341 gtttgatctc cataaatcca gttggtttcc ccatgttcct ctccccttcc ttactgtact 1871401 accgcttgtt tttgtcccga tgctgctgta ttctgctttg gcttcgtgtt ggcctcaaaa 1871461 gcgaacatga tggcttcttc atctgataaa cctgcagctt tttgctcttc gatgcttgcg 1871521 agcatttgtt tatagttttt cggaatgact ttgacgaatt ttttcacact gtcttcccat 1871581 tgatctagca gatcttctgc tttttggctg tttgtatacg cagtatgtct ttcaagcatt 1871641 gctttgattt gctggatttc tttctcatcc tctaatgatt caaataaaat catctcaagg 1871701 ttgcatttgc gtttaaacgc tttgacatct tcggtcagta cataagcgat tccgccggac 1871761 atacctgccg caaagttttt gcctacatca ccgagaacga caacgctgcc gccagtcatg 1871821 tattcacagc cgtggtcgcc gatgccttct acaactacgt tcacaccgct gtttcgaacg 1871881 gcaaagcgtt caccagcacg cccgttaata tatgcttctc cgcttgtcgc accgtaaaaa 1871941 gccacgttgc cgataatgac attgtcatcc gaagcagagt tgaatccttc tgatgacttg 1872001 acgatgattt ttccgccaga aagccctttt ccgacgtaat catttgagtc tccgtccaaa 1872061 taaagcgtca tccctttagg aacgaaagct ccaaagcttt ggccggctga tccggtaaag 1872121 tgcagcttga ttgtatcttc aggaagacct tcttctccgt aacgctttga gatttcactg 1872181 ccggttatcg ttccggctac acgatttgta ttattgattt caatcgaaat atcagcttct 1872241 tttccagatt cgatggcttc ttgtacggcc gggagaattg ttgtaatatc aagtgattga 1872301 tcaattttat gattttgcgg cgattggaac gtccgcaccc cttcaggctg ataaagaagg 1872361 gtagacaaat caagctggct tgctttccag tgctcctttg cccgttcact tgcatgaagt 1872421 acatcagtgc ggccgatcat ttcatcaaat gtcttgaagc ctaacgcagc catgtactca 1872481 cgaacttctt cggcaatgaa cagcatatag ttcacaatat ggtcaggatc tcccatgaac 1872541 tttttgcgaa gctctggatt ttgtgtcgct acaccgacag ggcatgtatc caaatggcag 1872601 gcacgcatca tgacacagcc gagtacaact aacggagccg ttgcgaaacc aaattcttcg 1872661 gcgccgagca aggcagccat cacaacgtcg cggcccgtca tgagctttcc atctgtttct 1872721 aatacaacac ggtcacgaag tccgttcagc attagtgttt gatgtgcttc tgcaaggcca 1872781 agctcccacg gaagccctgt atgtttaata ctggttttcg gagaagcgcc tgtacctccg 1872841 tcatagccgc tgatcacaat gacatctgca gtcgctttgg caacacctgc agcgattgtt 1872901 cctacacctg cttttgacac cagctttacg ctgattcttg cgtcacggtt ggcatttttc 1872961 aaatcgtgga tcagctgggc taaatcctca atcgaataaa tgtcatggtg tggcggaggt 1873021 gagattaatc cgacacctgg cgttgaccca cggacatcgg caacccatgg atataccttg 1873081 ttgccaggaa gctgcccgcc ttcacccggc ttagcacctt gagccatttt aatctgcagc 1873141 tcatcagcat tgacgaggta atggcttttg acaccaaacc gtccggatgc aatttgtttg 1873201 atcgcacttc ttctatcatc gccgttctca tctggaacaa agcgtttggg atcttctccg 1873261 ccttcaccgc tgttgctttt tcctccaaga cggttcattg cgattgctaa agcttcgtgc 1873321 gcttccttac tcaaggaccc gaatgacatc gcacccgttt taaaacgttt gacaatcgat 1873381 tcagcggatt caacctcctc caacttcaaa ggcttgcggt ttccgtcaaa tgcgaacaag 1873441 ttccgcaaaa atccgatgcg ttcttcatca gccgcttttg tatactgttt aaacagattg 1873501 taatcatttc tgcggcacgc ccattgcaaa gtatgaatcg ttttcggatt aaacgcatga 1873561 tgctctccgc catttctcca ttggaagtca cttcccggtt caagcgtttt gctgtaatca 1873621 tcctgatacg cttcccggtg gcggcgctgt gcctcttctg caattgtttg taaatcgatg 1873681 ccgcctagct gtgatgcagt acctgagaaa tagcggtcga tcacatcgcg gctgattcct 1873741 accgcctcaa agatttgtgc gcctctgtag ctttgcacag ttgaaattcc catcttggac 1873801 atcactttta cgacgccctc agtaatgctt tttccatatt tgctaaccgc ttcttcatag 1873861 ctgatatcca aacggccttc atcaatttcc tgcttgtagg tcgcataagc gagataaggg 1873921 ttaatcgcat ctgcgccata accgattaac gctgcaaagt gatgcacttc acgtgcttct 1873981 cccgattcca caataatgct gaccttcgta cgcagccctt tgcggattaa gtgctggtgc 1874041 agtgcgctta ctgccagaag cggcggaatt ggtgtcagtc gttcgttcat ctttttgtct 1874101 gataaaatta acaaacttac gccttggctg atggctttct ctgcctgtgt gaacatgtcc 1874161 tttaaaccgc gttcaagatc ctctgaaaac agcacatcaa ttttttggct ttttaaatca 1874221 ggatgaacaa tcgttttcaa tgcgtaaaac tgttcattgg ataaaacagg tgtatacagt 1874281 ttaatccggc gaacatttcg ttcacttgga tgaagaagat cgccttccgc accgagccaa 1874341 gtcatcgttg aagtgacaag ctgctcacga atcgcgtcga ttggcgggtt cgttacttgt 1874401 gcaaacagct gtttaaagta gttaaacagc gattgcgctc ggtcagaaag tacagcaagc 1874461 ggagcgtcat tccccattga accaagggga tctttgcctt ctttaataac aggaattaga 1874521 tacttttgga tatcctcata tgtgtatccg aatgccttct ggcgagtaag aagatcacta 1874581 aattgttctt cttctcttga ctccggatca ggatttactt gtacaagctc ttcttcaagc 1874641 catttttggt acggatactc agttgcaatt tgtgttttga cttcctcatc ggagataata 1874701 cggccttctt ccaggtcgat taaaagcatt ttcccaggct caaggcggtt tttatataaa 1874761 acgttctcct gttcaacttc aataacgcct acttcagatg agaaaataat ataatcatct 1874821 tttgtgacat aataacgggc cggacggaga ccgttccggt caaggatcgc cccgatttgt 1874881 ttaccgtcag taaatgaaat agctgtcggt ccgtcccaag gctccatcag ggagctatgg 1874941 tactcgtaga acgccctttt ttccttggac atatgcgtat tttccgtcca aggctctgga 1875001 atgagcatca ttgccgtatg tgccggtttg cgtccagcca tcacaaaaaa ctcaaatgcg 1875061 ttatccaaaa tggaagagtc actgccatca gcattgagaa tcggcaaaat cttgtttaag 1875121 tcctcaccga agctttcaga aacaaattgc tgctcacgtg ctctcatcca gttgatattt 1875181 ccgcgaaggg tgttaatttc accgttgtga accaaatagc ggttaggatg cgctctttcc 1875241 catgtaggga atgtattggt actgaagcgt gaatgaacaa gcgcaaaagc agaaacgaat 1875301 gcttcgtctt gcagatcaga ataaaatgca tcaacctgtt caggtgttaa aaggcctttg 1875361 taaacaatgg tctggcttga aagactggca aaataaaaat caagaccttc cgttactccc 1875421 caattttcag cctgtttacg aatgacatac aattttcgtt caaaagataa attgtccttt 1875481 agatcagaac ttgcgccgat aaatacctga cggacaaacg gacagctttt ttgcgccact 1875541 gttccgattt ttccgacatt tacaggtaca gttctccatc caagaacgac ttggccttct 1875601 tgttcaatta gtgcattgat ttgcttttca attttttttc tttcatcttc cttctgtgag 1875661 aaaaagacca ttcctacccc gtaacgttct ttttctggca gattgatgtt tttgcactct 1875721 tttctaaaga aagcatcagg gatttgaacc agtaagccgg ctccgtctcc tgtatccgga 1875781 tcactgcctt gccctcctct atggtctagc tggcaaagca tcttaagtcc ttgtttgaca 1875841 atgtcgtgag tctgcttgcc ctttaagtgt gcatataggc cgattccgca tgcatcatgt 1875901 tcaaattcag gacggtagag accttgagct tttggcattt gattgtacgt cataattcct 1875961 ctcccccgat caatttccga taataccggt cataaaatct aacaactcta taatcattgt 1876021 aggttttcaa aacgatataa acaatatata atttagatca aaagaatctc aaaatgagat 1876081 agatggatgt gagacaaaca tggagctgcg ccaactgcgt tattttatgg aggtggctga 1876141 aagagaacac gtttcagaag ccgctgatca tttgcatgtg gcccaatcag caatcagcag 1876201 acaaattgcc aatcttgaag aagaattaaa tgtgacctta tttgagcgtg aagggagaaa 1876261 tatcaaactc acgccaatcg gaaaagaatt tttaattcat gtgaaaacgg cgatgaaagc 1876321 cattgattat gcgaaagagc aaattgatga gtatcttgac ccgcatcgcg gaacggtaaa 1876381 gatcggcttt cctacaagcc tcgccagcca gcttttgccg actgtcattt cagcgtttaa 1876441 agaagaatat ccgcacgtcg aatttttgct gcgccaaggc tcctataagt ttctgattga 1876501 agctgtcaga aaccgcgata ttgatctggc cttattaggg ccggtgccga cgaatttctc 1876561 tgacataacg ggaaaaatat tatttactga aaaaatttac gcgcttgttc cattaaatca 1876621 tccgcttgct aaacaaaaaa cggttcattt aatcgatttg cgcaacgacc aatttgtatt 1876681 gttcccggaa ggatttgtac ttagagagat ggcaatcgat acttgcaaac aagcaggctt 1876741 tgctcctctc gtttccacgg agggtgagga tttggatgcg atcaaagggt tagtgtccgc 1876801 aggaatgggc gttacccttc tgcctgaaag tacttttgct gaaacaacac ctcgttttac 1876861 tgtgaaaatt ccaattgagt tccctcaagt aaaacggact gtcggaatca ttaaaccgaa 1876921 aaatagagag cttgcgcctt ccgcgaatga tttttatgag tttgtcattc aatttttctc 1876981 taagctggag cagtatcaat aaaaaaaatg aacccgagct tctatataga agcttcgggt 1877041 ttttttctgc aaattaattt acaggtaaag aaaaatccac atggcaaaca aatgcttctt 1877101 gatcaattag agctctattt gtcagttcct ttttcttttc cggttcttga agctgtacag 1877161 aagagtaatt gacgattcca aggccgattt ccgtcccttt tgaatccatc agccgaacaa 1877221 ctgaaccgct tttgaatttc cctttaatct tctgtacacc gtctaggtat aaactcgatt 1877281 gtccgtttgt tatttttcgt gaacaatcat ctgataaaat catttcacct tccggaccgg 1877341 aattaaaagc gatccattgc tccttttgat tcaacggaag cgttccttct gcttcaaaat 1877401 aggtgccttc cgcctgttca tgaacggcgt ggtataaaat atcgccagca tctgcctgac 1877461 ctaggaaacc tttaatgcca gacgccatta cgattttaaa cgcatcaagc ttagagcgca 1877521 tgccgccggt gccaacgatg cttccagtgt cacctgcgca tgcttcgatg tcaggtgtta 1877581 tttcactcac ccgctgtatc tttttcgctt ctggatttgt gcgcggattg ccgtcatata 1877641 atccgtctat atctgataaa atcacaagca tatctgcatc aatcaatcct gcgacttttg 1877701 ctgcgagcgt atcattgtcg ccaaacttga gccgattgac ggtaactgtg tcattttcgt 1877761 ttatgatcgg gatgatgccg cgctcgagca gtacattcat tgtattcctg acattgttgt 1877821 atcgatattc atcagaaaaa tcgcttctcg taattaaaat ttgggatgcg acatagccgt 1877881 gtgccaaaaa cagctttgaa taagcctcca ttagcaatcc ctggccgatt gaagctgatg 1877941 cttgtttttc tggaagcttc tcgggccttt ggataaatcc gagcttccga tatcccgccg 1878001 ccactgcgcc tgaggaaacc aaaatcactt cataaccggc gtctttgagt ttgacgacct 1878061 ggtcgaccaa cgcttctaat tttcgaatgc tgatttctcc atgaaggctt gttaatgaac 1878121 tgcttccaat cttcacaacg actcttttca tgcttgtatc aggcgtcact ttatcactcc 1878181 tgatagcggc gctgcagttt tttcgatatc ttcgctgatt tcctttgaac gcttagccgc 1878241 atgctttatt gcttgagaaa tcgcttctcc gccgccgctc tttttcaagg cttgcagccc 1878301 cgctgctgtc gttccgttcg gtgacgtgat attatctctt aagatctcag gatgttctcc 1878361 tgtttccatg agcatttttg cggcacctaa aagtgtctgt gcgccgatgc ttcgagataa 1878421 ctgtttatcg aggcccgctt cctcgcctgt cttttcaatg aattccatta aataataaaa 1878481 atacgcgggt ccgctgcctg caattccggt gaatatatcc atttgatttt cttggattgt 1878541 atagacttcg cccatgcatc cgagcaatgc ttcggccagc ttcttcaggt cttccgacac 1878601 atatttgcca agggcaatag ctgttgcaga agcgccaatc atactggaag tgttgggcat 1878661 cactctgaca accggctgtt cattaagcaa tgattgttca ataaaagagg tagttatgcc 1878721 ggcaaggacc gacaatatta attgatgggg ttgaatacgt gattttagtg atgacagagc 1878781 gttttcggcg tcttttggct tcattgccaa aatgagcaca tccatgtctt caatacatag 1878841 ttggttcggc aaggcgcctt taatgccata ttgaagttca agttcagtta atcgctctgt 1878901 attgctgcgg tttgtaacgc agatgttttg tttcgggatt ttgttggctc gaacgatacc 1878961 tgatatcatt ccttccgcca tagatcctgc tcctataaag gctactttct tttgatcaaa 1879021 gatcggtaac atctcctttg ttcgcttttt tgttcgcatt ttcacacgtt taaaatgtta 1879081 ccacgtgagg aaatgatgtc aagtttgaag gccattattg atttgtattg tttcttttcg 1879141 acaaatatgt ataatgaaaa gcagaaaaca cccggttcac actgctgcgc cgggtgtttg 1879201 tttctattaa aaattatctg agagagcttt ttcaatcagt tttttacagc gatccagctc 1879261 taccttcagc tgttttttat atagcttggc agcttcgtaa tctttaaatt gatagaggac 1879321 gacttcctgg agcttagccc cttctttttt tactttaatt tgttttagta tcccgtcatc 1879381 aagaagctca tgcaaagacc ggtatacttc tgtatgattt ggtttaaaac caatctcttt 1879441 aaattcagac cgaagtactt caagcagctt taacccatag agtctctctt gctctgtcat 1879501 cgttatcata taaagcttca aaaatgcgcg ctgtttcact aaaaagcctg ttgaactcct 1879561 tttttcttct ttcatcatat gcactccttc ttctgtcact gacaacacta tgtactaaat 1879621 attcaatttt cttttattgt tttccttctt tatattaaag actgatagtc cagttatttc 1879681 atgtttactg attataggtg tagcggaaaa aataaatttc gactgaacat ttggtacata 1879741 gttttcttag ttctattata gcctgcattt actgctatct tcaatttaaa cgattgccag 1879801 ggtttacata tctcatttta ccggtacgga tttcattcaa ataaaaaaac ctgtcgaaag 1879861 acaggttttc atttttaagg atttgttgac cataatcccg ctgttttgat gaaaatacga 1879921 ggatctaatt tcagttgtgc caccatgtac tcagcaagat cctcaggctg cataactttt 1879981 tcaggattac cgtctgttaa gttcaattcg atagacatat cactagcgac agtgctcggc 1880041 gttaacgcgc tgactctgat attatgtttt ctcacttctt gcataagaga ctctgttaac 1880101 ccgagaacgg caaatttaga agcgctgtaa gcacttgtta cagcagctcc tctttggccc 1880161 gctgtagatg aaatattaat gatgtctccg gctttgcgtt cgatcatttc cggaagcacc 1880221 gcgcgagtga catggtacac acccattagg ttgacttgaa taatattttc ccactcatca 1880281 gctgacagat ctaagaaacc gccaaatttg ctgatgccgg cattattaat gaggatatcg 1880341 atatcaccga gctgttcctt cacttgagct acagcttggt taacctgatc ggcatctttt 1880401 acatctgcag cagcaaatgc agcttttaca ccaagcgctt tgacttcttc agccactttt 1880461 tctacattag cggaagtccg gccaattaac ccgatattca cgccttcttt ggcaagcgcc 1880521 agagcagtag cgcggccaat tcctctgcct ccgcctgtga ttagtgcagt tttatgttgt 1880581 aaactttgca attgaagcac cctttctttg tttacatatg tacgatatca cattataagt 1880641 acaatacatc caatacgcaa atcaaacgaa ctgtgtaaat atcatttctt ctgattaaaa 1880701 aaacggatac agggtaatga cataagaaaa ggagtgaaca tatgattata gtttatatca 1880761 gtcttgcagt attagcagtt tctattatct tcttaggagt taccgtgatc caaaacaaga 1880821 aaaaaataga ccccgcacta aaggagcttt cctctgttac gcaggctatg caaaaacaaa 1880881 tcgaaggatt aaaaacagaa acagagctgc tgacgcaaaa acaaaagaag attcagcagg 1880941 atgtccaaat aaaaaaatac acgcttcagc agaccgcagc tgaagtgaaa gaagttcccc 1881001 aagcagtcaa agaggtgtgg caggcaggac attttaatag cagataagga tgaatgagat 1881061 cccgttgtta cgatcagaat ggacaaatgg gatctcattt ttcgaggagg cttacacatg 1881121 attataaacc gcagctgctt aaaagagttc gcagaaaaag tacattttct tccctcttca 1881181 cttacaaagt ccgatttact tactgatcca tttcgtctcc atcaagaaaa cgaacttggc 1881241 atctactatt cacctcataa tgaatttatc aatcgggatg cctcgcttgt gattgccggg 1881301 atcacgcctg gtttttccca gatgaagaca gcgtacgaaa cagccgccga aagcctgctg 1881361 caaggcggga ctcttgagca aatggcagta gacacaaaaa tagcagcggg tttctccgga 1881421 tcgatgagac ataaccttat taccatgctg gatttatgcg ggctgccgca agcttttggc 1881481 attcaaagcg ccgcaaagct ttttggagaa ttacggcata tgctccatac aacttccgtt 1881541 attaaatatc ctgtctttat ccagcaaaaa aactataccg gatacaaacc ggctatcact 1881601 cattctccta tcctaagcac ttatgctttt gggcacttcc ctgcagagct taaccatgtg 1881661 acgggaccag ctcttctcat tccgttagga aaagcggccg aaacagtgtg tgaaacattg 1881721 atcagacagc acagcctcca gaatttgatt tgccttaacg gctttcccca tccatcaggc 1881781 gcgaacggcc atcgtttgaa acaattcagc aaaaacaaag agcaactaga aagacaaatt 1881841 cgttcctttg ctgcattggt tgatttcgct atagaaaaga ggaaataaaa gggatatgat 1881901 aaacaaaaac acaaacgtgg ggagtggttg aatgtttcct atattagaaa cggatcggct 1881961 tatacttagg caaatcacag atcaggatgc ggaagccatt tttgcttgtt tctcaaacga 1882021 tgaggtgaca cgctattatg ggcttgaaaa catggaatct atagaacagg ccatttcaat 1882081 gattcaaacg tttgctgccc tctatcaaga aaaacgcggt atacggtggg gaattgaaag 1882141 acgggacact aaagaactga tcggaacaat tggctttcac gctctggccc aaaagcatag 1882201 gcgcgcggaa atcggttatg aaatcatccc ggagcattgg cgaaacggat ttgcatcaga 1882261 agtcatttca aaggtcgtat cttacggatt ttctgccctt ggactgtcgc gtattggcgc 1882321 agttgtattt accgataatg aagcatcaaa tcgtctgctt ctaaaaatgg ggtttcaaaa 1882381 agaaggcgtt ttaagacagt acatgtatca aaatgggact ccatatgata caaatgtgta 1882441 ctctattgtg aaaccaagag aatgacggta ttctcttggt ctgtgccaca tcccttttcc 1882501 tttaaaaaga taaaaagcgc ccctcaaaca gggcgctttc taattaagat gcatattgag 1882561 gagatgtttc ctccttaact gctttttcct caggtatatg aatacatttt gtcaagaccg 1882621 cacttgcaag gtaaagggcc gcaaagatcc agacgacacc ttgcgcgccg acgagaccga 1882681 tgaacagcca agcgagtgca gggccgacaa acgctgataa acctgcagct aaattcaata 1882741 cagacatggc tgccccttta tcttttcctg ccaccgtcgg cacaattgca ccaatcggca 1882801 catagcctgc cagcaaaccg ccccaaataa agccgatcac gctgacaacc gctaaacttc 1882861 cgccggagaa aacaggtgcg tagtataata agacggtgaa aatgccgcag ccgactccgc 1882921 cgaaccaaat aacagtattt ttccagccga atttatcgcc gacaataccg aagataaggt 1882981 taaacacaat gttccccagg aaaatcgttc cccaaatttg cagccacaca ttggttgaaa 1883041 ttccatgctg ggccatgtgc atcggcaaaa agactggaaa accatatgta ccaatgctgt 1883101 tgatgattct gatgattccg cctgtaagca cgcgcggatt tgtaaataga atcgtaaccc 1883161 cttttaaaag ctcctcggct gtttctgatc tttttctttt cttcttttca aaacggtctt 1883221 tattgataaa caatgcaaag aatgcaccga gacataccca gaaaatagag ctccaaagcg 1883281 tattcaaata accgaacgct ttgatcgcgt agcttgagta ccaagcgccg aacacaaaca 1883341 tgccgaggca atatgcaatc caaaaccagc cgacagcagt gctcagtttg ctttgcggtg 1883401 ttctgtaaat gacccatgtc aagaaagaat aagcaaaaag cgggtaacct aaccctttta 1883461 cgaagtaagt cacatacatc actggcaggt tcagctgttc aaatccaaat acgataaaag 1883521 cagctgtacc gatcacataa aacaacagcc ccataaacat cgttcgtttt gcgccaaatg 1883581 cttcgagaca tacacccgaa aaccaggaag ctatggcaag cgcaattccg tatatactaa 1883641 aaatggaagc ggactgctga acggtgagcc cgttttcgat caaaaaagga ctgagccagc 1883701 cttgttcaag gccatctccc atcataaaca aaacaacccc taaaaatccc caggcaagcc 1883761 gcttcggtat tcctatttta tccaacatat ctgtctcctc cttagatgct attattcatt 1883821 accgtattac cttattaaag ttgaaaatta aatgattcct caaaacagca gaaattccgt 1883881 cttaaattaa tactttgctt tctgatcctg aaaaaaagcg ctgtgtttgc ttccattcct 1883941 catataaagc caattctatc tgacagtcct tcggttcgat cacccggaca tttgctgaca 1884001 tctcctccgt taattgaaag gtttcattgc aaatgactgc agcaccgacg acagatgcct 1884061 gatgatatcc ctcttggaca tagacctttt tttgaagaag atccgcgata tattgagtga 1884121 gcgctttgct ttggaatccc cctccgcaca cccaaacata atcacgttca aacggagtaa 1884181 cctctgttaa aatgtcaaag ttccatttga ttgaaaatgc gatctcttct agcgctgcac 1884241 gtacaaaatg tgccctcttt aaatgtgctg acagcggggc atcaaaaaga aaaccgcctc 1884301 tcgttaacgc attcttttca gccgataaat aagagccgag agccgctaca catgcatggt 1884361 cttcttttgc aagtgcagaa atctcctcct ccattacttc gtacgtttca ttcggataaa 1884421 aaatctgttt taatttttga taattcaagc cggtaattcc cggattcgtt tccacaagcc 1884481 aatgcccttg atccgtatga cagttcaacc aggctttatg ttttgtgtcg ccatgatcct 1884541 cagtaatttt ggttattggc gttgttgtcc ctgatacaat gacaatgtcc tcaagtccag 1884601 ctccggtgct tttgacagcc agctgtgtat ccccgccccc tgctataacc ttagcattta 1884661 ttgaaaggcc taattcggat gcatattcat ttgctatcgt tccaattgct gttcccgctc 1884721 ttacaagagg cggaaggata gatggagaaa agccgaaaat gtcgcacatc tcttctgacc 1884781 aagtgttttg cttcacatca aatagcaggg tttctgttgc ctgtgatggt tcatatgtta 1884841 atattccgct cagttggtac gtcacccaat cactgatgct tgtaaagctt gcagtctttt 1884901 cccataaaga gggctggcgc tgttttaatc cataaagctt gagcgcagaa aaaagtgcag 1884961 ttggcaggcg gcctgtgctg ctgtatatct cttcccaatc gggaatgccc gcctcccact 1885021 ctcggccgcg attatcgatg ttcggcagcc cgagaaaagg attgccgttt tgatcaatca 1885081 aaacaatccc ctgtctttgg ctcgtcgatg tcaaaccaat gatgtcaata tcacacgaac 1885141 gggatagcgc acgttttgcc aaattcatca cctgcttcca cagcacctga ggagaaaaat 1885201 aacggctgtc cgggtaaagc gtctctgtgg aatactcgat gtcctcccgt tcaactgtta 1885261 gaacactgcc agttacactc acgaccgcta ccctcgcatt gcctgtgcca atatcaaaaa 1885321 cgagatagcc tttttgtttt ttcattctgt tagcctcctt tcttatcccc ctgttttcag 1885381 tgcgtccttg ttatacattg tctgaatatt aagagttttt tcacccttcc actttttgag 1885441 ggctttattc agtatcgtca cgtgatgatc ctccacttca aatgttgctc cagcgagatg 1885501 cggtgttgcc agaacattag gcaatgaaat caattcataa tctgattcct ctggaggttc 1885561 atgataaaaa acgtctagta tcgcaccgct gattttatgt tcttttaata caaataaaag 1885621 atcttcacgg tttacaacaa ctgctcttga agtattaacg aaaatcgcac tctctttcat 1885681 cagatcaaaa tattgccgat ctatcagtcc gagtgtttcc tcagtgcgag gcagatggac 1885741 agaaacgata tcgctgtctg aaaacaccgt tttaagagat gctttttcat acaacggatg 1885801 atcgtcttga atgtatggat cgtaatattt tatcttacag tcaaacgcag tcagcagttt 1885861 tgcaatcctt tgcccgactg cgccgaaccc aatcatgcca accgtttttc ctgttagctc 1885921 atttccttta aatttgacat aagcctgcag gtaatcactg tcccactctc catccttcag 1885981 ccactgattc gaggcgctgg tatggcgcag aaaggaaatc acatttccaa taaacatttc 1886041 ggcaacggct tgtgcattcc gccctggtgt ataaaaaaca ggtatgcccc tttttgaggc 1886101 agctgccaca tccacatttg agggcattcc cctgcaaaca ccgacaaatg aaagttcggg 1886161 aacagaagca aatacgctgt ctgttacctg atcaagttca gtaatcaagc ctgtcgcatt 1886221 tgttgctttt agcagctgaa tgagttcatc ctcccgatat gccctacctt gttccttcca 1886281 agattgataa gcaactgagc caaacaagtt ttcaagctct tttcgtcctt cttcgttgta 1886341 cggtgctgta accaaaaccg tcatgctgca aaacatcctt ttcatcgtat ttttcataaa 1886401 aaaaatctct ttccgaagat ggaaagagat tcatatatag gcgcgctctg ttacaggcag 1886461 acgccggtat aaaccttgct ttcctatctt tcaagctagc gcttgctgga attggcacaa 1886521 taatgttgcc gaggtttcat agggccagtc cctccacctc tctggataga aaatattgag 1886581 tatgtaattt tcagaatgaa gaatacgttt atcataaaga agactcagat tgatgtcaat 1886641 ctcttttttt cagaattgac gttatcatcg gaaatgttat aattcttaca aaatatctaa 1886701 ctagagagag gaactgggcc atgagatctt ttgccacaca acaaaacggc attttcaaat 1886761 ccgtttgctc gctggactgc ccggatcagt gcggattgtt aatacataaa aaagacggga 1886821 aaatcgtaaa agtgcaagga gaccctgatc atcctgtcac agctggaaac atatgcaaca 1886881 aagtccggaa tatgacggag cgcatctatg atgaaaagcg gctgactaca ccgctcaaac 1886941 gaacaggtgc gaaaggccaa gcgatatttg aaccgatttc ctggaaagag gcaatcgata 1887001 cgatcacctc ccgctggaaa cagctgattg atgaagaggg agctgaaagc atacttcctt 1887061 acagctttta cggaaatatg gggaaattga cagctgaagg aatggaccgc cgcttttttt 1887121 accgcatggg gtcaagccag cttgaacgga cgatttgcag caaagcggga tctgaaggct 1887181 ataaatatac aatgggcata agcgcgggaa tcgatcctga ggaaaccgtt catacaaaac 1887241 tatttatttt ttggggaatc aacgcggtca gcacaaatat gcaccaaatt acgatcgccc 1887301 aaaaagcgcg aaaaaaaggt gccaaaattg tcgtgatcga tgtgcataaa aatcaaacag 1887361 gacgtcttgc agattggttt atcccaataa aaccgggaac cgacagtgca cttgctcttg 1887421 gcatcatgca cattttattt aaagaaaacc ttcatgatga agcatttctg tccgagtaca 1887481 cggttggcta tgaagagctc cgtgaacacg tgaaacaata tgatcctgaa aaggtatcga 1887541 cgatcaccgg tgtcagtacc gaagatattt accgactggc aaaaatgtac ggggaaacct 1887601 ccccttcttt tatcagaatc ggaaacggac cccagcatca cgataacggg gggatgattg 1887661 taaggacgat tgcctgtctt ccggcgatca ccggccaatg gctgcacaca gggggcggcg 1887721 caattaagca taacagcgga attttagaat ataacacaaa tgccttgcag cggcccgact 1887781 tattgaaagg gcgcaccccg aggtcgttta atatgaatca gcttggcagg gtgcttttgg 1887841 aaacagaccc gccgattcgc tctctattta tttacggaac gaaccctgcc gtcgtcgcgc 1887901 ccgaagcaaa caaagtcaga cagggcttgc tgcgggaaga cttgtttact gtggttcatg 1887961 atttgttttt aacggaaacg gctgcatatg cggacattgt actgcctgca acatccgctt 1888021 ttgaaaatac tgatttttac acctcctact ggcaccatta cattcagctt cagcagccgg 1888081 tgattgagag atatggggaa agcaagtcta acactgaggt tttccgatta ctggctgaag 1888141 ccatgggatt cacagaccag gagcttaaag attcagatga agtattaatc cgccaggcgc 1888201 ttgaccatcc agataatccg catttggcag agattgatta cgattcactt actaagcatt 1888261 catttatgaa agcgaaacgt gaaaagccgc tgtttccggg cgaacttcca acgccaagcg 1888321 gaaaaataga attatattca gaaaaaatga aacaagacgg cttccctgct ttaccgacat 1888381 atacacctct tgtaaccgat aatgaacatc cgtttatgta tgttccgggg ccaaaccata 1888441 atttcttaaa ctcaacattt tccaataatg aaaaacacat caagcttgaa aagacgccaa 1888501 agctctttat caacacaaaa gatgctgaaa aacacggaat cgttgatggg gcacctgtac 1888561 gaatttggaa cagccgggga gaatgcgagc tgaccgctgc agttggagaa caagtgctgc 1888621 caggtgtcgt tgtcagccaa ggattatggg cggatgaaca aggaaaaaaa cagcttgtaa 1888681 acgcgctaac cccagatcgc ttgtccgata tgggcggcgg cgccaccttt ttttcaggcc 1888741 gtgtacagat tgaaaaggtt tgaaaaataa tgaaacccgg agtatgccaa gcccgtataa 1888801 cataacatcg acataatgga ggcatacaca tggacgtttt tttaggaatt ggtattgctt 1888861 tggctggata ttttatcggt gaaggcttaa agcagaggaa ccaaaccaaa ggtaatgaac 1888921 aaaatgatat cttcctaata aaagaacggg atatttactt ttacattgga ctttttttag 1888981 gaataacaac gactgaagca aaacagttag ctggagacat ggcagacctg ccttacatcg 1889041 aaataaacgg aaaaaaatat gtccagaaac atatgttaaa agattggaca ttcacattag 1889101 ttgaaaaaca tcagggtgaa taaaacaaat ctgaggagag cgagattcat tgtcacgctc 1889161 tcctctgttt agctgtatgg atcctgccac caaaactttg tgctataagc gctgataaaa 1889221 cgataaacca ccatctatgt tctttcctca aacaactcaa gatgcccgtt ccacaacaat 1889281 agtttttata ttcctttgat gacgtgatgt tcttgatgaa cgtatgtatc gtaaaacact 1889341 tagaaaacct attcggtttg aatgtgtgct ctcattatgc ccccatactg cgcctttatc 1889401 cgcggaggat ttttttaaaa aaatatgaaa cctaaagctt ttagatcctg aatttttatt 1889461 gaacctccat atttctccga ttggtaaaaa ttagcctata caccggaagc tgtacgttta 1889521 taaaggatca gagaatccca taaccagtaa atcactgcag ccgcaatact taacatataa 1889581 taaaagtacg attgcaatgt ccatgctatt gacgcaggtt cattgataac aaaaaacagg 1889641 aaagctgcga taaaagcaac cacactgtaa atcaataggt acatgacatt gaaagttctc 1889701 gcttttttct gcaacttcat ttggagcgga acagcaaaaa ggccatacac cacaaaaccg 1889761 tataataaag caattgctgc cgtaaacaat gcaattatca tatcgccata cataacgaaa 1889821 gaataaaacc ctaataacaa accaaatgta aggctggata gccctaatgt cattaaataa 1889881 tatgatgcga tttttttcat tttttcaccc cccttgtttg atttattcac agtgctgtta 1889941 gtataaattc acaacctttg tatttctttt atcgagatgt cttccctaac gtgctatacg 1890001 caatgcgcta ataaaaggtt tcaaaaatga cgttctttta ttagataata cgctggctga 1890061 aaacgcctct cctgattggc caaagcgcga atgaaaaaag tgcatgaata cctgcccaac 1890121 agacagaata agaagagttg atatttcaac acttttcgta aaggggtgaa accaatgagt 1890181 aagaaaggta ttcaaaattc aagtattgaa caaataagaa atgaccatga gactgaaaca 1890241 gcttttaaag cagatgatcc taaaaaacac ggttccgatc ctaaaagaac gaaataagtt 1890301 cttaccccca ctaaaatatc aataatctgg aggaagtaaa gtgactcaaa aaaacggtgc 1890361 agacagacct gatgattata aaagattttc ttcattagac aaggaatatg attttcagca 1890421 atctatacgc agcaatactg agacagaaag tgtaaacact gaaacacaaa ctcataacaa 1890481 agaaaacaaa aatgacacaa cagatgttgc cgggaaatac tttgagccct cagattataa 1890541 aggaagcacg caattagaaa aaggattggc tgaaactcat gaacaggtca gcgatgacta 1890601 ttttgaaggg acaatcgatc aaaatttgga ctagccatac aaacggaact aacttaaaag 1890661 aagtcagtta actctgtttt tagaaacaac cacagtaaaa gtagccaacc cccaccgaat 1890721 aagatggggg ttgcacgtaa gtagcctgtt taatatttaa aacgattaat gacggtttga 1890781 agttcttctg ccaactgaga tagagattct gcggcatagg agatttcccc cattgaatga 1890841 agctgttcct gtgatgaatt tgcaaccgct tctgtatttg ctgacgtttc ttttgtacca 1890901 gcagccaatg tatgaactgt gtgctgaatc acttcaacgc ctgaagtaag ctgttgagtt 1890961 gctgctgcaa cttcttgtat ttgagaagtg acctgttcca ccaggttcag tatttcattg 1891021 aaatttcctg ttgtctcttg agaaagaaca atacctgagc tcacattttc ttgaacaact 1891081 ttaatattat ttaccgtttc tatcgattcg ttttggatgg tcgctaccac cgattggatg 1891141 tggtttgcag atttatttgt ttcatccgcc aacttccgaa cttcttctgc caccacagca 1891201 aatccttttc cttgctctcc ggctctggcc gcctcgatcg ctgcatttag tgccaacaaa 1891261 tttgtctgct ctgaaatcgt cgtgataagc gaagagatat cgctgatttc tgctgtgctc 1891321 gctaccaatg tttgcaatcc attgccggct gaatctacag atttatcaat gaatttcatc 1891381 tggtctaaca tcttgttgac ggacttagag cctatttcag ccttgtctct catcgaagaa 1891441 gaaagatccg ctatgttccc tgtatttgaa gcgactgatg atatactgtc taataattca 1891501 gtgatggatt ctgcgctctt ttctgtcatt gagctttgct tcacattgct gtcggcagcc 1891561 atctgcatgg ctcgtgaaat atgttcagat gttgatttcg attcttccgc gcttgccgat 1891621 aattcttcag aggaagcggc gacttgttca gatgagctgc tgatctgctt cacaatttga 1891681 gttaatgaat gagtaaaaga attaaaagat tgggcaagct ggccaaattc atctttattt 1891741 ttcacaatga cttttttggt taaatcagcc tcgccgtgtg caatttcctc cagctgctta 1891801 tttatgcttc ttagtggcac cataatggac tttaacagca ttatgcttag aacaatgcct 1891861 aatattactg atatccctgt gacaatgata atgagcgatt gactcatttt cccattgccc 1891921 tgtatttcat cctttagatc ctctacctct tgatccaggc gatcagacag cttattgaca 1891981 gccggagcta cgccttcttt tcttattgtt ctttcttctc caaaatggat ggtttctgct 1892041 tttttaggat ttgaagagta ggctgttact acttgctgat tcaaagctct atactgagta 1892101 aaacttgtct taatgtcttc aatattggat tgatacttct cttcatcaat caagtcatta 1892161 acccggtcaa ggctctttaa gacatcgtct gcttttccct tcataccctc gtcgtattct 1892221 ttgtctctgg taatcaagaa gcctctttca tcatttgata acccggtcaa ttcatattgg 1892281 atgtgtttta tctctttttg gaattccatt ttgtctttaa gttcttcatt ctttttcaca 1892341 gtagaagaaa tcataaatac tgaggagcct ccaattccaa taattgaaac aactaatatt 1892401 gatataatcc ccagcaattt tgttttcact ttcatgtgtc gttttccctt tccgcacaat 1892461 gtaatggctg aaataaaata tgttcaagcg cgtttgaatc caattcgctt acgctcatgt 1892521 ccataatatc gacacgtgtt atcaagtttt atagtgatat tcttatatga ataagcaaat 1892581 tctttacgtc tctgaactta cagaaaaacc ttaagtaaaa tttgcagtct tttgcggtat 1892641 gtaagtcact cttattcgtt tttctaaaaa aggcttttcc cacctcaaat tggctgaacc 1892701 ggctgttttc tcgaaaatat aatacaatac gcagcataat atgaaggagc gaaacttaaa 1892761 tggggatcat caatggtaaa gaattcattg accgattgaa taaactagaa aacgaaatat 1892821 ggtatgatgg cgaaaaaata aagggtaaca tttctgagca tcctgcattt aaaggaataa 1892881 tcaaaacaaa aagctcactt tatgaattgc aaacaaagga tgagttaata catgaaatga 1892941 cttattgcct tcctggagat cataatcgaa tcggcctttc ctatctccag cctaaaacaa 1893001 aaaatgattt gaaaaaaaga aggaccatga ttgaacattg ggctagacat actcatggaa 1893061 tgatggggag aagtccggat tacatgaata cggttatgat gagctttgct tcgtcagcgg 1893121 agcttctaaa agataaagag aattgctttc ctgaacatat actagatatg tatgaacaag 1893181 ctgctaagca tgacctttcc tttacccata cattcattac tccgcaagtg aaccggtcac 1893241 agtcctattt tgggctaagt gaaaaaccga tatctgctaa agtcattgat agaaccgaaa 1893301 aaggtttaat gattcatggc gcacgactgc ttgccacaca aggcgggttg accgatgaaa 1893361 tcttggtttt ttcagcgcct aaatttttct ttgaaacaga tgaagcttat gctttttcaa 1893421 tcccttctaa tacaaaaggc gtaaaattca tcacaagaga atcatttgta ttaagcgact 1893481 cttcctttaa tcatccctta agctcaaggt atgaagaaat ggattcaatt gtggtttttg 1893541 atcatgtgtt agtgccgtgg aatcgtgtgt ttttttacga taatgtggaa gcagctaaag 1893601 attttatgac aaaaagctct tttcatgcct ttacctttca ccaggttgtc attaggcaaa 1893661 tgataaaaat tgaatttcta ttaggtgttg cacagcttct tgtcgacacc attaatgttt 1893721 ccgaatatca gcacatccaa gaaaagctct cagaaatcat tgtgggattg gaaacaatca 1893781 aagccctcat tgacaaatcg gaaaatgatg ctcagttaga tgaattcggc tatatgcgcc 1893841 cctgtttaat tcctcttcaa gtcatcagta cgatcattcc taagctatat cctcgattta 1893901 ctgaaatcat acaattaatt ggagctagcg gaatggtgac actgcctacc gaaaatgcat 1893961 ttgactcaga gatacgggaa gatcttgacc aatatcttca agcaaccaat acaaatgctg 1894021 aagaacgtgt gaaaattttc cgtttggcat gggatttaac aatgagttca ttcggaacta 1894081 gacaaactca ctacgaaaga tattttttcg gagatcctat tcggatttca agcaggctgt 1894141 ataccagtta tccaaagcag gagcagttga acatgattaa aacattttta catgcagata 1894201 cagaacattg aaaaaacagc gggaaaagat ccgctgtttc gtatttttta ttcaggaaac 1894261 tgaacatggc ccggtactgt ataggctttg gacgttccgc tttcaggcag ctttggaatg 1894321 gtgtctttca caacttttcc gcggatgtca gtcattctga ctttgagaga gccagtacct 1894381 aaattcgtac tcacaaaatg gttatagtcc attttctcca tgttgatcca cttaccatcc 1894441 ttttcatatt ccattttcat aacaggatac ttgtgatttc tgacttggat tgctgcccac 1894501 cacctgctgc tgccttcttt gatccggtac gtgaaattgc cggtgattgg ggctttgaca 1894561 acacgccatt taatattgat ttttccgtct ttcatattgc cgattttacg gaaggcatta 1894621 ggtgacagat caagagctcc ccgagcgcct tcgggataaa gatcagtaac atatacggtt 1894681 gttttccctt ttggcccttc aacttccaaa taagagccgg caagtgccgc ttttactcct 1894741 ccgtaattga gatccgccgg atttattgca gtaatctcca tatcggaagg aatgggatcc 1894801 agcaggaaag ctcctcctga atagcctgac cctgtatacg ttgcataacc ttcatgcagg 1894861 tcgtcatatg ctgccgaagc ttgcggggaa aaacagaaga tcgtcaacaa aaccatacca 1894921 acaaatgcac tcatgatctt tttcatattt ggtcctcctc aaaccagact tcaaatgaga 1894981 atcattatca ttataagact caatccatct ggtttgaaag aggaaataga ttcatagttg 1895041 attttaaggc aaattcacta tcattcatat atcaaatgta ggtacttatg aaaaagccaa 1895101 tacaaatgaa cgaatgtgca cttcagccga atgtcttatt tttccctctc aaaattcgca 1895161 tttcaataac gaaatgaaac aggctgttgg cctgataaca gctatacagg aaaagctatt 1895221 tttccccgct cagtttcaac ttagctgtca tcatgatgcc aaagatcagc acaatcggaa 1895281 cccaaataat gaagtgataa aaatcaggct cagccagagc aacaataata gcccctacac 1895341 aatacaaaat aatagccagt gctcttaaca cagtatctct taagaaagtc ttcttttgct 1895401 tcttaaaaaa caaacggccg gatatatcct ctaaaagaga agccaaagtg ccggtcaaca 1895461 cagttgaaga aatacctgca atccccagtt tttttgctgc tgtagtttga atccccatag 1895521 aaatgctcat gagtataatt agaatgtgca caggaacaaa tgcccggtaa aaagaaagac 1895581 aagcaaagac aaacaaaatg aatgcttcaa gtgcgagggc ttttgtcaca gcagaaggcc 1895641 aaagggtatt ttccgccttt ccgaccatca atgtagcaat gatcacgccg catataaatc 1895701 cgattagcgc agtcaaggaa ttaaaaacag tgacctgaat ggatttgccg atagctaacc 1895761 ccaataatac aatgtttcca gtcatattag ctgtgaacac atgtcccagg cttaaatacc 1895821 cgattacatc cacgattcca gctgttaaac ataaaagtga tagcaaggtg tttcgataag 1895881 ctgctgcagt caacggtgta tcaatccttt cttctatttc aattgttagt atgtcttttg 1895941 gcgcaatctc tattttttaa gtaacccaac attaattagg aagatagaac ctattattcc 1896001 tttccattaa ctgtaataat aatccccgca aggaaatgat taaaattgaa aggaagcata 1896061 ttgtgatgaa acgactttgt ttatggttca ccgtctttag cttgtttttg gttctcttgc 1896121 ctggaaaagc attaggtgca gtcgattttc cgaatacctc aacaaatggc cttttaggtt 1896181 ttgccggaaa tgccaaaaat gaaaaaggca tctctaaaac gggcacaacg ggtggaaaaa 1896241 acgggcagat tgtttacatt caaagcgtaa atgatttaaa aacccatcta ggaggatcca 1896301 ctccgaaaat tttagtgctt caaaatgatc tttccgcatc tgcgaaaaca acagttacca 1896361 ttggctcaaa taaaacactc gtgggctctt acgcgaaaaa aacgctgaaa aatatttatt 1896421 taacaacttc atcagctttt ggaaatgtca tttttcaaaa tttaacgttt gaacacagtc 1896481 cgcagattaa cggaaataat gatatccagc tttatttaga ttccggtatg aactattgga 1896541 ttgatcacgt cacattctca ggtcatagct ataatgcaag cggaagcgat ttggacaaac 1896601 tcgtgtatat cggaaaatcc gcagattata tcacgatcag caactcaaaa tttgcgaatc 1896661 ataaatacgg tttgatttta ggatacccgg atgattctca gcatcaatat gacggctacc 1896721 cccacatgac aatcgccaat aattattttg agaacttgta tgttagaggc ccaggtctga 1896781 tgagatacgg ttactttcat gttaaaaaca attacagcaa taattttaac caggcgatta 1896841 caattgctac aaaagcaaaa atatattccg aatataatta ctttgggaaa ggcagtgaaa 1896901 aaggcggcat ccttgacgac aagggcactg gttatttcaa agacataggc agctatccat 1896961 cactcaacaa gcaaacctct ccgctgactt cttggaatcc tgggtcaaac tatagctatc 1897021 gtgtccaaac gccggaatat acaaaagaat ttgtcacgaa atatgccgga tcacaaagta 1897081 caactctggt atttggctac tgatataaaa gaggccctgc gttaaaaacg ctgtgcctct 1897141 ttttatacta taggctattt ttaagcgatc cttgtaattc catcaagatc cagcgtcggt 1897201 caaactaaaa agcatatgtt cttttccaca ataacttctt aactggcttt cttattatac 1897261 cagtttatcg caagtgaaaa gaaatcattg ttctgaacct gtattaaatg aacgatcgtc 1897321 ccacaaacta cttaaaaacc cctaaaaagg atgatggata tgtgcggcag gtttactttg 1897381 tactctgcat ttgatgatat tattgaccag tttgacatcg atcaattttt tcctaaaggt 1897441 gaataccagc caagctataa tgtcgcacca tcacaaaaca tccttgcaat catcaatgat 1897501 ggatcaaata atcgcttagg caagcttaga tggggactta ttccaccttg ggcaaaagat 1897561 gaaaagatcg gttataaaat gatcaatgct cgagccgaaa caattaccga gaaaccggcc 1897621 tttcgaagac cgcttgtcag caaacgctgc atcataccag cagacagttt ttatgaatgg 1897681 aaacggcttg attccaaaac caaaatccca atgcggatca aattgaaatc atctgctctt 1897741 tttgcgtttg ctggcttata tgaaaagtgg agcacacatc aaggataccc tctttatacc 1897801 tgcaccatca taacaactga gcctaatgag ttcatgaaag atatacacga ccgaatgccg 1897861 gttatattgg cccatgatca tgaaaaggag tggcttaacc ccaaaaatac aagccctgat 1897921 tatctgcaaa gtttgctgct gccttatgat gctgatgaca tggaagcata ccaggtttca 1897981 tcattagtaa attcacccaa aaataattca gctgagcttc ttgatgcaga aaatcatatg 1898041 tagtgattga aaaaattctc tagcaagaac ttgtcaaata gctttgttcc ttaggtgcca 1898101 atccctctag taattatgaa tatttagtac atagatcaat tagttatctt tagcatcagt 1898161 ttgaaataat tttattatgt aaacttaaat aagcaatgtt attcctttca tataaaatag 1898221 tttacatttt tataaaatcg cttcactttt ctattttgtc agcaaaaaaa ctgaaccaca 1898281 ttaaacttat gaaacctgcc gcacctgtgg attgcaaata tgatataagc ccatagaggt 1898341 aaatccatac actttccctc ctaagaatta aatgaaattt ctttcatctt acatgaaggt 1898401 cttctttctt ttgtttatcc agtgtaatac ttaataatat gttgatgaat gcagctggaa 1898461 aatatataaa tcccactcca agaatgccta gtatcgtact taaacttact atgtaattct 1898521 ttgtcatcgt ttgactgtca atcaatatta gaagtgaaat caatccagct aaaacaccta 1898581 taaaccaagc atcgccaaca gcataagaat catccagcat ccctaaccat cgccccaata 1898641 tagagctccc aatggcagtc aaactggata aaaatatgag tgctttcatt tcttctcctc 1898701 ctttaaagcc aatcaaactg gtagaaatcg gccattgaat ccccattatc gaatggttac 1898761 catttcattt ccacattaac attttaaagc tcattacaat acgattcaag cagaaaaacc 1898821 ctacataacg tatatatagg gatttaataa aacacaggcc aaaattcagc tctatctact 1898881 ttaaaaagat atgaagggca gctgtgtgat ctgttacgtc tttacgtacc gggatatttc 1898941 acaacaggca ctttcttctt gcgcagagaa tcaagcatga ctgatccagc attcaagttg 1899001 ctttgtacta attctttagg cgtcaatgcc atccactgat tgagtgacac atctgcatag 1899061 cggttacttt tgaacatttc taaaaaccat aatgtttctg taccagtgtt ttgtatatag 1899121 tgtccggcat tagaaggcac gtatccaacg tcgcctgctc tataatcaaa tgtgcgggca 1899181 gtcccatttc cgataaatac cgtcattcgt ccctgtcctg ttagataata ttgccactca 1899241 tcgctattgg gatgccaatg aagctctctc atcgcgccag gctcaatctg aacaagtgca 1899301 gcggctatcg tttttgaaat tgggaagtta gaagaatcca caattcgtac actcccccct 1899361 ggcatttgaa ttgggggttg atttaacagc tcgtgtttaa aggtcatggg gacttttcca 1899421 tatggtgact gaatgtcttc actggcgact gatcccggca cattcccttg gtagatatag 1899481 acttgctcag acggaagaga gttgaaagca ttctccggga caccgaaatt tgcagacaga 1899541 acatcttttg gtgtgtgtgc aagccaatct gaaatggtta acgttgaaaa ctcagaaaag 1899601 ttcccatcat cgaaaacgag cagaaactcg cagtgttcca atccctgtat ggaatgcgga 1899661 attcctgccg ggaagtacca aaggtcgccg ggaccaacat cagcaatgaa atttcgtccg 1899721 tcttggtcaa cagcggtgat acgtgcccgt cccaaaagca tataagccca ctccgcttgc 1899781 ttatgccaat gaagctcgcg gacgcctccc gcagttaagc tcatgtttac acctgcaatc 1899841 gcagtcgaaa tcggaagctg tcttacggtg atttctcttg accagccgcc gtgatctaat 1899901 ttcatgggag cgtctgagaa tgaaaatctc aagttaggaa tcataccctc atctgtaaca 1899961 ggcggaacaa atatattcgg attttgaata tcccgtatta tatttcgcgg gcctgtatca 1900021 atagctccag ctccatcact tcgaataggc tgcggcacgt ttctgtcttc atgattgatt 1900081 ggttgttgtt ccaacagcat gcacctcgtt ttagaaatga acaagatttt atttcagcct 1900141 atgcagaatc ttagattgct gtgcctagga atccgcaaat aaaaaagtga ccaccaatgt 1900201 gatcacaaat acatcaaata aactattttt tataccatgg cttcttatgt aatttgattg 1900261 cttctgtctg ttttttctgg cctgtcctcc actccacttt tactaataca tcatgaccta 1900321 tcacttcatc ttcaggcata taatcaaagg tggaaatatg gtcctccatg cgtcccccac 1900381 ccggcatttc atcacctgtg tactccgata agtcgtactc atctacgtta tcatcttgat 1900441 acttttcgcc atctacatac agagtaattc tttcaacaac agtccacttt tcttccttct 1900501 tactcccctg ccaatataga tttagaaaat aattgggtcc aattgaagtt ttgtctgatt 1900561 tttcaaggtt agacatccac agtccgcttt tcccgctgcc ctcatatttc actttgttcc 1900621 ctgacaccat tacaaataat gtgatgatgc agatgatcaa gaatccagca atgatcaata 1900681 gccatttctt aatattgttc ttttttctca tgtttttcct cactttccta actttttagt 1900741 aggaaaatac gatcaaaatg ttaccgaaaa gaaaataaga aagggctaat gatctaacag 1900801 atgactgtct aaacttttga cttaaattaa agtgctttct aaagacaaga ttaaaacgta 1900861 taacagctct taaatgcatt ttttgtttca ttgagtcaag aaccttaaaa tggcttttta 1900921 ttattaaaaa tcaagctagt gtattaagta acttttcaaa tttatttata ctcatgatct 1900981 cgtgagtcac aaatctccca tcaaaaaaaa cgctaaaagt tgtccaaata gctggtgact 1901041 tttgtgcctc ttctttcgat gataactgaa ttgactgaaa ttgaacccct ttcttttcag 1901101 tcaattcccg caaatcattt atcatgccca ctgcaaacgg acactgagct gtatagtata 1901161 tcgtaatccc cttttcattg atagaatcac ttttcacctg gctcttaaat gcaggagaat 1901221 ctgcaaggcc attccaagtc aaagccatta attgaaaata aggggcagct tcatcttgta 1901281 gagtaaaccc catatgctca aagaaatgct tatcacttaa atagggcagt tttttcttgc 1901341 ctgcgatatg gataatgcca tccatgccgc acgctttcgc atctgctata catttgtcca 1901401 acaatcgttt cgcatgaccg ttatttttat atctgccaga cacccacaga caattaatgt 1901461 acataaaatt aggcgcattg ataggcaccc atgcctcatt cgcaggtagg tattcaataa 1901521 agacttttgc ccgttcatgt aagcgataga acaccaatcc ttcatccatt cgagctttga 1901581 gccatctctt cttttcatta actgcatgct catattgttt cgtgcttaat gcacagcaaa 1901641 tatgattgtc ttcaatattg tcctttgtga tttcaatgta gcacatctcc tctttccccc 1901701 ctttaacata attacatgga attcaacttc acactttaca tgcctaatag aataaatacc 1901761 cgttccaact taaatacttt ttcttttcca ttttgccaat taactgtaaa acccttcttt 1901821 tattcagata ttatcttgat tcctatatca cccatttcaa atccaaagtg tgttcatctt 1901881 tgaggattag atgcactgct tatgctataa atacagtaca cgaagttttt tatttgaagt 1901941 aatatttgtt acgggacagc aatagtaaat aagtgataaa aggggaatta aacttggtgg 1902001 aaaaatgtta ttcttgttta atttgcggat acaaaggatt aattcaaaat cctttgtata 1902061 aaggcgagta tcaaaaaacg tttgacattt gtccatgttg cggttttgaa tttggctaca 1902121 gtgaggatca tgatgtgagg ttaggtttta ttgtaactcc tgatcattta attgaggctg 1902181 catttcaatt gtatcgcaaa caatggcttg agagcgggat ggtaattgct catccggaag 1902241 atattccaga agaattgaaa aatggcaatt gcttaaaatt tgaagttttg ttgaaacaat 1902301 tgaaaaaact aaatcttgac atagaaaatt ttgaaattag cggtttttaa tgatgaaaca 1902361 ggttgcactt gtttaggttt cactgtcatt atcagtaaaa tgttaagttg aaatgcgcaa 1902421 tcagtcacaa agtctctatt cgtattcaat aaagactttg tgatcatcga caaacatttc 1902481 actcccatcg gataaagtat ccaaaaggcc tcctctggtt cttctctata gtcattaatc 1902541 acagtcactt tgacatttga ctcagctatg attggttttc caacaatttt tcgttttttc 1902601 ctcaggcaaa gtaagagatc gaatcatcaa agccattcca tctttactgt ctaattaacg 1902661 ccatcttcag tgaatttaaa ggtctgtttt aaattgcgtc cttcttgccc cttctgtgtc 1902721 caaattataa caacctctaa ttcagaggcc ttatctgcca gcataaaatg attgaacttc 1902781 agcggtgagc catcatttaa actttcagct aacattttag aatcttcttt tggtttgaca 1902841 caattttcat cgggacatcc aaaaagcgaa aaccttgtga ttgaattagg gtcatttcta 1902901 tacaattgca catccactgt agctgctttt tcccctatat ttttgacttc caaggaatat 1902961 acttgatatt ctcctttatg aggtctcgta aattccttta cattttttgc ttcacttact 1903021 tttactgacc actggtctgt tttttgtgta ataggcaaca ccgtaaaagt cagggcatgc 1903081 gcttttgatt ggcaaaacgt aaatccaact gctgtaaaaa caattacaga aaataatacc 1903141 cttttcactt catttatccc tccttccttt cactggccgc tccttaaaga attgattttg 1903201 agcaatctac aagctctctt aaccaaaacc ttacctgagg ttttgtcttt actgctctgc 1903261 atttatttct ttcggtatcc gagaaggagc tttggggatt tttctcaatc tgctgttaat 1903321 cacatcagaa gagtatagcg taataatcat acttccccca tacctttttg cccgaattaa 1903381 gattggttgg ttatattggt tttgaaagcg aaagtcagga cctccccagc ttaccgtcgc 1903441 atcccgtccg ggcggtacat atggtacact tctagtatga gaatagcgct gaacgatctg 1903501 cagtcctgca cgatctactg cattaaatag agttgaggac acctgacaaa ttcctcctcc 1903561 tacaccttca gacaactccc cttttacaat aatgggtgca cttttatatc ctttgttccg 1903621 agttctcatt cccacaactt ggttaaacga aaacgtctca ttagggaaaa caacgtgatt 1903681 gtcgattgct tttgcagaaa gagaaatatt gtgtgaacgg cttttattgc ttgagttaaa 1903741 atacgtcacg tactgaccaa gctgctgcgt actgatgtga gctagcagct cgctgtcaac 1903801 tttcggataa atgttcattt ccggcacttc tatcttggag ggaccttgcc cataaaaata 1903861 cgcataaaac ttttccataa acgcctgttg atacagtttg tagccaaccc tgcccgggac 1903921 gatgcttcca tgatcgttaa ggacagcatt tatcggctca cggtacactt tctgatcaag 1903981 ctgtttgatg aatttactgt atttttcata gtcaaccatt ggagtgccgg gaagaggcat 1904041 tgtaaagtct tcacggttaa cagtggcaat cgtccgtcct tgctgtgtga ccgttaaact 1904101 gtcctgcggc tcactcggct gagccaataa aaaaagacca gtgatcaaaa tttgtatcat 1904161 aagtcggttt acctcccaat cattagtatg aacagccgct tatcctttga tgtatttctt 1904221 cccatcgttt gtttgaatct ttagacgttg ataaaaacct tcataaaaga gcttagcttt 1904281 atgttcacac cgatccctga gctcactgag gcacacggtt cattcagtcg gcaagtttga 1904341 agtagttcag catctcccag tgatgaggga tgcttttttg tcttgtcaaa aatgaaaagg 1904401 gtctcctata acaacaaaaa atcaatccat ttcaatattt ttttattgag aaacgataaa 1904461 ttttttgtta cattcaatta gacaacaaat aaatgaggtg cttgttatga atcgaatgtc 1904521 gacaattttt ttaaagatag ctttggttct tattggaatt ccaattcttg ctttatgcat 1904581 ttttttagtg cctaaggtag ccaactattc agcagaatta tttccaaata tcgcttatat 1904641 aaaatatctc gttttcatct atttgtatgt aacggcgata cctttttact ttgctcttta 1904701 tcaagcgttc aaacttttaa gctatattga caaaaacaaa gctttctcgg gtttgtctgt 1904761 aagagctttg aagaatataa aatattgcgc agtcactatc agtatctttt acgcagcagg 1904821 catgcctgtc ttttatctga tggccgagat agacgacgcc ccgggtatca ttgtgatcgg 1904881 attggttatt atttttgctt caatggtgat tgcggtcttt gctgctgttc ttcaaaaact 1904941 gttaaaagaa gcgattgata taaaatcaga aaatgactta acggtctgag gtgatgacat 1905001 ggcgattatt atcaacattg atgtgatgct tgctaagagg aaaatgagcg taacagagct 1905061 ttcagagaga gttggcatca ccatggctaa tctttcgata ttaaaaaacg gaaaagcaaa 1905121 ggctattcga ttatcaactt tagaagcgat ttgcaaggct ttagaatgtc agcccgggga 1905181 tatattggaa taccgaagtg atgaagacac aggattcgta aagaaaaaat atgaaggatc 1905241 aacagaaaaa taaagtgatt ggcggtgagc ttatggacat aaacttatat ccatctagct 1905301 gctatactaa gcgtcccttt catacacgaa gaacacaact atggaggagg catacatcat 1905361 gagagccata aaacaaatcg tccattttgg ctgggaacaa gccctttcat gtttgtttcc 1905421 tgccgttatt tttgcctctt tggctattac gcaaatcatc ccactgccct tcttgccgcg 1905481 gtatgactgg ctgctcatta tctgcgttct catgcaattg tggatggtgc gttccggtct 1905541 tgagacacgg gatgaattaa aagtgatcac attattccac cttattgggc ttgctctgga 1905601 actttttaaa gtccatatgg gctcctggtc ttatccagaa gaaggatact ccaaaatatt 1905661 tggagtacct ttgtatagcg gctttatgta cgcaagtgta gccagttatt tgtgccaggc 1905721 atggagaagg cttaaggttg aactggttaa gtggccgtct ttttttgcag ttgttccgct 1905781 tgccgcagcg atttatttga attttttcac ccaccatttt tctatagaca ttcgatggtg 1905841 gttatcaggg cttgtcatca ttgtcttttg gcaaacatgg gttacatacg aggtgaatgg 1905901 agctcgttac cgtatgccgc tcgcactttc ttttatactc atcggatttt ttatatggat 1905961 agcggaaaat atcgctacgt tttttggagc ttggaaatat ccaaaccaaa tcgatacatg 1906021 gagtctcgta caccttggaa aggtaagttc atggctcttg ctagtgattg ttagctttct 1906081 tatagtagca tcattaaaac aagttaagga gcagagtccc acaaaggcag agatggatga 1906141 atctttttct tagcatacgc atacaagctc ccaaatagag tgaaaagcaa cgttcaaatg 1906201 gttgcttttt tcttttatgt aactctgccg gtgagtattc atcttcttca aatttcatcg 1906261 caacacgata actgattcag attacaactg ctttcaacac tttgacaaac tcatgcgccg 1906321 ccggcgttat ctcttcaaat gaatgtgcga tgacgccaat atcgcgtgtg accctaggaa 1906381 agatgtcctt tttaatcaat tgatgcggga cggatgaaag tgtaaagttt gaaatgatgc 1906441 cgatacccaa gttatttttg accatattaa tcaaggtttc ggcattttgc acagttaagt 1906501 tttcctttaa ttcgatgttg tattgcgaaa atgcgtttga catcgcgatt tcatgaccgc 1906561 ctttacaaaa aatgaggtca tcttgatatg tttcaaggtc gacatgcttt tcaagtttta 1906621 attcgtcacg ctgcggcggg atgacggcca ccatatagtc gttacacaat agctgatttt 1906681 caaacggttc aaatggagat gctgcgatcc cgatatcaac cgtccgatct tcaacccatc 1906741 cttttatttg gtcagaggtt ccttcgatca attctatgcg gatcagcggg tagtttgatc 1906801 tgaatgccgc aatcgcctgt ggcatgatat ttgttgaaac tgcaggaaat gaaccaattt 1906861 tcaccttccc gtttaacagc ttgttttccc ggttggctac ttgatatatt ttgctttcaa 1906921 ttcccttcat ttgcctcgcc agcagcaata tttcttttcc gatgtcagtc agcattaaac 1906981 catgatgttt atccctgatc aataatttga gctgcagtga gctctccagg ttttttatcg 1907041 ctttacttac cgccggctga gagatgaaca attcttttgc cgcttctgta atatttaatt 1907101 tctccccaac ttttacaaat atgtgaagat ggttcatgtt cataaccatt tggttatacc 1907161 cccaataata aaaatgtatt tcagttatac ataaatgtaa catatgatag aaaccagcac 1907221 gatattttaa caagaaaggc ggcttcatta tggtaaaagt tatgctggga atcatatctg 1907281 tcacacttat ttggggttat acttgggttg cgatgaaagt aggaattcat gacatccccc 1907341 cgcttttatt ttcgggtttg cgcctgttca tcggagcagt tcctttattt ctcattctct 1907401 tcatccaaag aaaaaagctt tcaattcaaa aagaacatct caaaagctat atcatcatga 1907461 gcctgttgat ggggctgggc tatatgggga ttttgacgta tggaatgcag tttgtcgatt 1907521 cagggaaaac ctctgttttg gtatatacaa tgcctatatt tgttacggtg atcagccatt 1907581 tttcattaaa cgagaaaatg aatgtgtata aaacgatggg actggtctgc ggcctcttcg 1907641 gactgttatt tatatttgga aaggaaatgc tcaatatcga tcaaagcgct ttatttgggg 1907701 agctgtgcgt acttgtggca gcgcttagct ggggaatcgc gaatgtgttc agcaagctac 1907761 aattcaagca tatcgatatt attcacatga atgcctggca ccttatgatg ggagccgtca 1907821 tgttattggt gttttccttt atatttgagg cggtcccttc agccgagtgg acatatcagg 1907881 cggtgtggtc attgctgttt aatggcttgc tttccaccgg ctttaccttt gtcgtatggt 1907941 tttgggtgct caatcaaatc caagcgtcaa aagcatccat ggcattaatg tttgttcccg 1908001 tattggccct attctttgga tggctgcaat tgcacgaaca gatcaccatc aatattatcc 1908061 tcggcgcact gctgatatgc tgcgggattt ttatgaatac atttacattt tcacgacgga 1908121 aagtgtgaat gatatacatt tcccctgtca tttgggcttc atgtgacagg agaagactat 1908181 tacgagaaag tcttctagaa tcctgacgac agcctattaa acaatgaaaa aagctaatgt 1908241 ctgcatgtag acattagctt ggctggcgtt taggctggtg agaatccaga tactttttta 1908301 ttaccattct ggctgatcaa actgaaaacc gtatagacct tttactttaa catctccgca 1908361 atctggatct tttgtcaaaa tcaaataatg agtcttataa ggcatcgtct caactcgatc 1908421 agttgcacta aaatcaaaat gatcccccga gaagtttttt tcactaacgg ttatttcata 1908481 tcctgacaaa gtcattcgca tgattcttgc gttaattgta catccttcag tatcgaaaat 1908541 ggtgaatctg tacccaaagt gagatgtcca atggtttgaa tttaggtcat cagacttcat 1908601 aaaccatttt tcattctctg tcattgtaaa actcactttc tcctcatctt tcacgataac 1908661 ggccgaagct tcccctacat ggatagtcaa agccaaaaga aatgtaaaag ctaacatcaa 1908721 catctttttc aaaagagttc ctcccgatat cttttacttc aatatattgg aagggtcttt 1908781 tctgatcaag acagtcttct ccaaatgaat ctttagcacc atgaaatgag ccttaataag 1908841 aacagtttta acccaaatca acctctattc gaaataaggc ttaccaatct atattctttt 1908901 taaaagtttc tgcatttctt tatttagctc ctagacacat ataaaaaatg ctcctataag 1908961 ttcaggagca ctacaaaaaa ctgctaaagt gttttctatc gatttattgt attcattagc 1909021 tcaaagaaat attcaggctt ttgagtctta tttagcttat accatgaacg caatgtatct 1909081 ggtgcaaata catctaattt tttcaatact tctaccgcaa attccagagg agcaattcct 1909141 gatgcagtaa ccaaattttc atcagatact gcaggcccct tttcatagaa tgtttctcct 1909201 ttgtaattag ggcagaccat attcatatag tcgaggtcat tgcttgtgtg ctttctcgaa 1909261 tttaagtatc cttcattcgc gaggcccaag gttgccccac aaattgcagc aatagtcgtg 1909321 ccgagcttta aagcgtcgcc aacttttttc aagatcggct gatgaatatc ttctccccaa 1909381 gtgtttcctc cgggtaaaat gataagatct tgactcccaa gagtacattc gtcaagagaa 1909441 atatctggtt ttatgcttaa tcctcccaac gtagttatca tttctttatt aacccctact 1909501 gtaactactt ttaaagatgc tgcatcttgt ttaaagtatc tccctgagtt tagttccgca 1909561 attaaatatc catattccca gtctgacatt gtgtgaaata cgtagagata aacttttctc 1909621 gtttgcatcc aataacactc caatcacaat tgataaagct ttctaataga tgactttgct 1909681 gacagtcatt gtcagctttt ttgttgattc tattcttatg cccttgttct cccaacttat 1909741 aaaaatataa gatcaattga ttctatgttt actagcgcaa aggggtttgt tacactaact 1909801 gtcatgggaa acatttcaaa ggtaatacaa aatcatttga atgaggaggc ctgatgaagt 1909861 tgaaaactaa agcgtcaata aaattcggaa tatgtgttgg gcttttatgt ttaagcatta 1909921 ctggtttcac accttttttc aactcaacac atgccgaagc aaaatccata gaagacacaa 1909981 acatggcaag ctgtataacg aataaaaaat ttgttcaact tgagaaaaaa tttgatgcca 1910041 ggcttggtgt ttatgcaatt gatataggtt caaacaagac aatcgcctat cggccgaatg 1910101 aacgatttgc ttacgcatca acctataaag ttctagccgc agctgctgtc ctgaagaaaa 1910161 actcaattga aaaacttaat gaagtcatcc actacagcaa ggacgatctt gttacatatt 1910221 ctccaatcac agagaaacac ctagatacag gcatgagcct aaaagaaatc tcggaagcgg 1910281 ctatccgtta cagcgataat accgctggga acatcttgtt gcaacagctt ggcggcccta 1910341 aaggttttga aaagtcactg aaacagattg gggatcatgt aacgaaagct aaacgattcg 1910401 agacggatct aaactctgcg attcctggtg atattcgtga caccagcacc gcaaaagcac 1910461 tggcaaccga tcttaaagcc ttcactttag ataacactct cacgactgac aaacgcatga 1910521 tcttaaccga ttggatgcga ggcaatgcta ctggtgacga actgattcgg gcaggcgctc 1910581 caataggatg ggaagtcggc gataaatccg gagccggaag ttacgggaca cgaaacgaca 1910641 ttgctatcgt ttggccgcca aacagagctc ctattgttgt ggcaattctg tcaaaccgct 1910701 ttacgaaaga tgctaattat gataatgctc ttatcgctga ggctgcaaaa gtcgtcctta 1910761 acgatctcaa ataatatgtt tagccttttg ccacaaagga aaagacatta cttttttaac 1910821 ttctaccgtt cattttttga tgaacggttc tttcataaga cctctagaat catatattta 1910881 aacaccacaa aattaaacat tattataatt aacagcaagt tttcatttta tggaacaagt 1910941 aaagtttgaa tctgacaaga attaagacta agcaccctaa aatccgtttt cttttcttcc 1911001 aagaatatac tccttagtgc aagccattat aaagatacaa gtgaacatac aatgcagaca 1911061 actctcttaa gtctcttatt ctgtgaccaa tttgtaatac tcatgaatat ccggactcac 1911121 ttccaatatt tcgtctcgtt cgaagacact aacatatcaa accacttgaa ttaacataac 1911181 tgaacttgat attggtcact ggcagtttca atgcaataga acaacatttg ttgtctcaga 1911241 ggttatctat atgagaattc aacaattttt ttataataat tcatattttt gtatcgttgc 1911301 acttggtgga tttgactctt ttcgtgtatg gaaccacact tttatttttt cacctctttt 1911361 gagatcatct gtgttatcaa tctcacttaa tcctacaatt actatgttat ttttaaactt 1911421 gttcataagt tgtccttcag aaagattgta atcttctttt cctggagctt ttgtatcggt 1911481 aatgagaatt gccctttcat tgtctttaag cacgacatag cctactaggc tctgcatctt 1911541 tgtttcgtct ccgttttgtt catttttatt gcagcctgca aggaaaataa tgagcataat 1911601 gagcactatc aagcttactc cgattttagg catctttctt cctcctcttt aaactcatct 1911661 ttaaaataaa caacaggata tcacccaacc catctacttc tttttgcaat tcataacagc 1911721 agcatactca ttctccaatt cctcaacctt ctttttattc tttctcaaat atttgcatgt 1911781 ggtagccctc gatattatcc gcttactcat ttttgcgctt tcaaatatat tattgaaggc 1911841 cgcttctttc tggattccag cataaatata cttatcctta ctgtcgttta ctatcgcaac 1911901 ttccattaaa atcgagattt ttactttttt tatgatccat tattcacttc caaaataact 1911961 tccaattaca acataatata tgtataaatt gtaaatggag ttgatgtaat tgaagattag 1912021 gaaaatctta ttgagttctg ctttatcctt tggcatgcta atatccgcgg ttcccgcatt 1912081 ggctgctggc acttcgtctg aggttgcagt aaaaaatgaa gaatatgatt atgacactat 1912141 ataccgcatt agtcctctgc caatggactt ccagccaaca atagaataca acggttatac 1912201 ttatacgctt acacgtcatt attttgatta ctcaatcggg ttttacacgg ctatttatac 1912261 aaaagttgtt taaacttata aaggagcttt ttagctcctt tttctcttgt tttaagcaag 1912321 gtatttcttt ctatgtggtc ccctatcaaa tacaacatca acattctcca gttctctttg 1912381 acacgaacaa aatctaaagt ttggttttaa atgctggtaa taaaaaattc actttaaaga 1912441 agtgccgccc gcaaaatacg gcttttgtac actacgccaa ttttatattg aaaagccaga 1912501 cctcctcaaa gaggttccag cttttcttaa tgtgctatcg atcttcgtta gttcaacggg 1912561 aactttatca ttcggtacaa atgcagcctc ccaacttcta gttagggctg atggcggaat 1912621 atctgacggt tctctacaca catcagacat tagaagattt caatgtagcc ttctgtacca 1912681 tgaacgcgaa ttcgttgccc atcttttatc agcttggcag cattttcaac gccaacaact 1912741 gcaggtaagc catattcacg ggctataaca gctccatggg tcatcagccc cccaacttcg 1912801 gtgactaggc cttttatgga tacaaacaat ggtgtccagc ttggatcggt aaaggaggta 1912861 actaatatat ctccatcttc taaatccgca tcttccatgt ttaaaatgac acgcgctcgc 1912921 ccctctataa ctccggagga aacaggtaga cctacaatcg ctccggctgg gagattttct 1912981 cgtttatact cacctgtaac gatttcacca tcagacgtga taacacgtgg tggagatagt 1913041 ttttcatata atgtgtactc gtcttttcgt gtactgatga tttgataatc cagtttatgt 1913101 gtgcgcacga cttcgtgaag ttcttcaaaa gtgagatagt atatatcttc tttttcatga 1913161 ataacgcccg cttctatgag ttgttcggct tctttcagta aagcctgctt ataaacgaag 1913221 tatcgattaa ccatgccgta ttttggatat tccctaaacc cgctgaaatt ccggatgata 1913281 tctatcgctc gttttgtttc tttggctttt tgttcaccat ccggtaattg cttcaatcga 1913341 tctaataact cttgttcttt cttcaaagct tcctgtcgcc cttgctcaaa tttccgatgg 1913401 ccgacattag gctcaaaatt tttaatatta ttaagaatca ttgggacaag tgtagttggt 1913461 ttttcgctcc atcgagttct tgtgatatca atctctccgg tacatcgcat tccgtatttg 1913521 ctgagataat catagatcgc gtctcgggtt ttgcttccgc catcaaactt agccagttca 1913581 tccaaaaagt tatcatcttt tacatgttgt aagtaatcaa ttacctctgg ataaggacga 1913641 atcacatctg cgacgtctaa tagcgcaaga cccatttctg aagtaatatt atggggtaca 1913701 gattgagaaa gcgtatctgc tgcgtttttt tcacctaacc actcgttcat tttttcgtta 1913761 atccataatg aagcattcat agcagttcga attagaaccg aactttttgg gttaaataaa 1913821 atcttcttta attcctgaat atcttccaga ataaaacgaa ataaatctga tcctgatttc 1913881 gtttggatgt tttgttttaa ctcttctatc gatgtttgac tgctctcaat caaatcagac 1913941 acgattgtcg gatcgttttc aacttgagcc ggcatatctg cattgcctct gctgggattt 1914001 ggtgctgttt tatcatttgg tatcgacttt atgaaatctc gtcgctttat tatggtcata 1914061 agtgcgtctt ttaagagctg atcgtgctgc cccatgcctt ttaagaaaac ttctctgctg 1914121 tcaggggatg ccagatgatg tgtgacatca acaaatagcc ttccaccggc tttacgcatg 1914181 ggtgcaacag tcgtcaacag aaaaaaagac aatcccagtg gttttatggg atccgtcatc 1914241 atttgttgat gaccaacaga aatatagacg tgattttctt ggtcactcgc ttcagggatg 1914301 gggaataaag tagtgattgg acgactctgt acaatataaa aagtatcgcg ggccaaacac 1914361 cattcgatat cttgcggctg gccgaaatga gcttcgatct gtcttccaat gcgtgccagc 1914421 tgtaaaattt gttcatcagt cagtgtttga gccttttgct gatcagaatc gatctgctgt 1914481 gtttctgttc cgccttcttt tcgtccgtag atagccattt ttttagttgc tattctctta 1914541 tcgatgattt gcccatcctg tactttaaaa caatcggcag ataccaagcc agaaaccagt 1914601 gcttcaccaa gtccaaaacc ggcatcgatg gataacacct ttcggttgga ggtaatcgga 1914661 tcagcggtaa ataaaatccc cgaagcctga gggaaaacca tcctttgaac gataacggat 1914721 aaatagactt ggctgtggtc aaatccattt tgcatacggt aaataaccgc gcgatccgta 1914781 aatagggacg cccagcattt actgatatgc tgcaagattg catcgacgcc ggtaatattt 1914841 aaataggtgt cttgttgacc ggcaaaagaa gcatgtggta aatcctcagc agtcgcacta 1914901 gaacgcacgg cataggcatg ttcctcgcca aactgggaga gatattgagc cactgctttc 1914961 acaacatcgg aaggaatgtc tacttccata atgatttgcc gaatcttccg gctgatgtta 1915021 ccaatctgat ctcggtcctc aacttttagc atggtcaatt gatccaacaa cacttgtaac 1915081 gtttcgtttt gttcgatggc tttttgatat cctactgttg tgacacaaaa tccttctggt 1915141 acttgtatac cttgaatttt tgataattcc cctaaatgta acccttttcc tccaacgagc 1915201 gaaagctgtg ttttttcaat ttcatgtaaa ccgagaacca aagaactcat tctacatctc 1915261 cccttcaaaa aaaaatattg acaagagctt cctagcagga tataataaaa ttataagatg 1915321 gatatctata actttttaac tagaaagcgc acgtagtgtg attatatcac cgtgtctgtt 1915381 tttgtgcaat ataaaaagaa cctgggaaat ttcaccaggt tcttttctta atttccatag 1915441 ctagtcgcat taaaaaactt ggtttgagct gattcaatcc tctaaggaaa tcctaaagtt 1915501 gggttctttt tgaacttact tgctttgttc gtagagtccc cattcataaa ttggactttt 1915561 tgttcttaac agtcccacct ttaactagta taaagttatg aggatctggt taactactag 1915621 atatttttat tttgaataag gcttatgttt gataaagaag ggttatgtaa aggtgtctgt 1915681 tgtgagcaag cgctgactac aaaaaattga tagcattctc atttaaatac cattctatta 1915741 acctataggg aaagttttaa aaccagatgg agaataccct acctccagca attccaaggc 1915801 cgttcaccta gtagaaaaca acctttaacc attactaacg attttaataa tcattgatta 1915861 taaaacttct caaggaacga tcagcagccc gttagctacc cctgattaag gatgatctgt 1915921 taccacactg ttacgttaga acttccacta ctttgatatc cttctgtcgc catgacttgg 1915981 taagcccaat tactgcccag attcattcca tggctcttcc atgcgttcac atgattgctg 1916041 aaagtgattg tagcgttgct tccggttggt ctcttcgact ggcgaacact ccagtactgc 1916101 gtaaaagtag tgcgatcgcc atcaatggaa ggtgcgttat aacgtgtagt tgtatatatg 1916161 tcatatgtac ccccatcact ttttacagta cctttatacg ttccagtagg tctataagta 1916221 ccccatgaat ccactacata atattctatg agaggtgatc tcgtccaacc atataaagtt 1916281 aaatatccat tgccattcgg cgcccaaact ccggcattat agtttatcgt cctaaatggc 1916341 gaacctgtag tccaaccttt accaacaaca aaatttccgg tattagacca attaacactg 1916401 taattcccgc cagacccatt gacagcgttt actataccgc ccccatcagt ccaattttgc 1916461 cagtagtctg tgctagctgc agaggcggtt gccgaaaaca agctaatact cattaaagct 1916521 gccgataatc caactaagaa attcttttta aacttaaaca tatgttacct cctataatat 1916581 tttttccgac tttgaggtag cactcgtata catttaaaac attcttaatt actaacgcca 1916641 aagcttttga tcgtcccctt cagtataata ccacgaattc atgagcaaat attaaaagta 1916701 tttgtaattc aattacaaat acctagaaac acattataag tggtcttctt ccaccatatc 1916761 ctgatccttt tttcgcagga tcacaattct tgtttctaat tcagatggag taatatctgc 1916821 aatgaattcc cattgaacca tttcaaataa aggagatata cattagagat tgtgaaatta 1916881 ttgtagctgc cgcttgtcta atgaagggaa gcaaatttat gaagaatatg aagaactgaa 1916941 gaagaaaaca attaaggtta tactaagaaa gaactgctca attaaaatta ttgaccaaat 1917001 ttgaggatga tagcttagat cagttttaca aagaagttgc aagattttta tttgaaaggg 1917061 ctctgaaaaa gaaaaaaaag aattgacaat cagggtaact gtgggatgta accgagcctc 1917121 caattcaaaa taaatatctt taactttctt tttttattta aagagggact gtatatccct 1917181 ctttaaaatt aagctttaga ttgctgctga aagtaataaa aattgtactt ttgatcaaac 1917241 ccttcttcgc taccacaaag aaaaataatg aattcaataa atgcgataat agaggggata 1917301 ccagtccagc aaaacaaaat atatagaata ccttgtccta ctcttcccaa ataaaactta 1917361 tgtattccca gacccccgaa gaaaaatgct aataatgccg ctacaatttt gttcttcttg 1917421 cttaccatga cttcctccta gttcattgct accattttta aagtaatgct ttcacattat 1917481 aatgcatttt ccgccagaaa tcgtgaaaat tttgaaattc ttttgagatt ttttatttta 1917541 ttgagaaatg aaagctcata taattgaact agatggtttt gggaggcatt tattcaaaat 1917601 gtattgccaa agattacggc aattacgaaa ggcacacaaa ttaacaatgg aacagttagc 1917661 tgagaaaatt ggaattgcaa aatcaagtta cggcgggtat gaagctgaaa gcaaaaaacc 1917721 accattggac aagttggtta ttttagctag actatatgat gtttcagttg attacatact 1917781 tggattaaca gatgatcctg atcctaaagt ggaaagaaaa aatctaaaag agtttttaga 1917841 aaaaccagat attcactggg atggatataa acttacccct gagatattag atcctatacg 1917901 gaaaattttg aagttggtta ctgcaaacaa caattaaaaa agccctcata agggcttttg 1917961 cataaaacaa ttatttcatt gaattttctg gactcatttc aagaagttta ttcatgatga 1918021 tagctaaact ttcaccagct ttttgtagct tctcacctgc ttttatcaga gtaattaaag 1918081 cacttaaaaa gtccactaag ctattttgat ttattgcaac tgtttcttta taagctttgt 1918141 aagcttcttc aaactgatca aattgcacac ctttcatagc aacaacagct aatttatctg 1918201 aaatatttcc atatgactct gttaaactaa aaaatctttt gacattgatt agtaaggcaa 1918261 tgcactttaa ataatcgtgc cccagaccaa tatgtaaatt gcctgcagca aacagcaaat 1918321 cgttcaaaac tgtgtacggt tcaccattcc ttgcaactgt ctcaatccct ttgtataagt 1918381 ataataaaaa gacaaatgaa tttttatctg tggaacgctc aggtaataag gacactataa 1918441 taacttactt taagccaaaa catccaaata aaaaggctgg ttataattat tataaaaatc 1918501 aataggaact ataaatatat aaagagggat tgctatgcca aaattatata catgtttaat 1918561 ttgcggatat aaaggattaa ttcaaaaccc attaaacaat gatggtgagt atcaaaaaac 1918621 atttgatatc tgcccttgct gtgattttga atacggctac agtgaagatc atgacgtaag 1918681 cttaggtttt attgtaactc cagattattt aattgacgct gcaattcagt tataccgaaa 1918741 acagtggatt gagaatggaa tgaaaactgc aaatcctgaa gatattccag aagaattaag 1918801 aaacggtgac tgcttaaaat tcgaggtgtt gttaaagcaa ttgaatagcc taaatctcga 1918861 tactgaaaac tttgaaatca agggatttaa tggttattaa gcagatccaa gcccccatat 1918921 gggggcgttc ttattattgt acagtctatc agaactattt atagaaaaac tatttaatgt 1918981 attgtataaa tatcactgac cttttctttc tccattcaac ttccttaacc ctcaactgtt 1919041 tgctgctgca tcacattcct cctttttgat ttttgtgtat caagcctgta caatattcaa 1919101 aaaccctaaa ggatgatgaa catgtgtggc aagttcactt tattttctga gtttgatgac 1919161 atcattgagc aattcaacat agatcaattc ttacctgaag gtgaatatca ccctagctat 1919221 aatgtcgctc cttcacaaaa catcctgaca attatcaacg atggatctaa taaccgtctg 1919281 ggtaaactta gatggggtct tatccctcct tgtgctaaag acgaaaagat cggttataaa 1919341 atgattaatg ctcgtgctga aacattggcc gagaaaccca gctttcgaaa gccgctcgga 1919401 agcaaacgtt gtatcatacc ggctgacagt ttttatgaat ggaaacgcct tgatccaaag 1919461 actaagattc ctatgcggat taaacttaaa tcgtcgaatc tctttgcttt tgccggctta 1919521 tatgaaaagt ggaacacgct agaaggcaat ctgttgtaca cttgcacaat catcacaata 1919581 aagcctagtg agcttatgga agacattcat gatcggatgc cagttatcct aactgatgag 1919641 aacaaaaagg aatggctaaa tcctaaaaat actgatcctg attatctaca aagcttgttg 1919701 ctgccttatg atgctgatga catggaagca tatcaggtat cttcattagt gaattcacct 1919761 gagctcattg aatcccatta agtaccactg ccatatcgct ttatatacca cctcctctta 1919821 gctaatatgt tctaagtagg aggtggtatt ttgtttgtat ctccaatgct attgcattca 1919881 ataaaagagc cttttgatga cgagagctat atcactgagc ttaaattatc aagactaaaa 1919941 ttaaaataag ggctcataca tagttgatat atataatatg tattgagacc tttattgaac 1920001 aaacgccccg tttgttaaag tggaaatctc tataattaat agccgacttt taaaagttcc 1920061 aatctaaaat tatcctctaa atcggctagc ttcattaact tctccgatat acctttccaa 1920121 tctttattta cagacataga atgacatatc ccaaacacct tagcctgttc agtcttcaac 1920181 actgataaat gtgaatgcct atctttaaaa tacattgcat aatcgttggc ccttcttgca 1920241 cttaattgga aaaggaagaa tgttgtatgc cttatagtat cagctgtaat aggggcattt 1920301 aataattgat cagcataaaa acaaattgct tcccttccaa ttaaccctat atccactttt 1920361 tcgaatttcc gataagttct cttaaaataa tcaattgctc tctcgtatat ttcgttattg 1920421 tctaatgtga caaccttttt tgctgtagac caatatttat tgattccttt cctatacgga 1920481 atcctttccg ccatccaagc cttcttaaat tggtccagtg ataatggaac aaatggaaag 1920541 cctgctggat cttgcacata aatattttca ttatccattt ggtaccctag aacataatgg 1920601 tcagaaccat ttaaattttt atgattcgga tggtatgtta gctcccccat atctaaaggg 1920661 cctagaatga cagggttttg tttgatttgc tgttttaata acggaaatgg gtcatctaag 1920721 tcactagctt gctgatgttc ttctgcagta aatccaagga tgtttaaagc ataattgata 1920781 ccatcatcag gatctctcat actaaaataa aggttttttt catattctat catggcacct 1920841 aacccaacac cagttaatat ctctacaagt tgaggagata cattttctcc tattgatgaa 1920901 agaaacattg cagttgaatt tgaataacag taatggccat ttcctatata cactaacatc 1920961 acctccgggt agataagtta accttacaat tttgaaaatt gaaaatccat attaaattgc 1921021 tccgttctcg tattcatcat ctggatcatt tttatcaaca ataatgatct tctcgccaat 1921081 ctccgtttta cgatcgacct ctacgtattc gcgcttgatg ctgctaagtg tttcgtcagc 1921141 cagtacgtga atcattacag ttgagttcgc tttaatttcc gtcatttact gcacccttta 1921201 tatttttttt atgttttttc aattcttttt agattttcat attggatttc actcttttaa 1921261 ttatagaggc gtgtcataca catgccatct aagagagata ggacaatttt gtcttggagg 1921321 tgaaagctaa tgaattttct tcttgatctt tttacaaatt ggacttttga taaagtcctg 1921381 gattatacac tagctgctgt aatttggtct gtatttaaat ccagatcaaa gcagaataag 1921441 tatccaggct atttcgagaa aatacgccgc tatagaaatt tacatcccct tctgcgatcg 1921501 ttatcgatgc gtgtactttt atcgataacg atccatcctt atatgtttag ttaaaaacta 1921561 tcttttattt agacttaatg ggataaaatc ttcattgtaa aactcttccc actcagcaat 1921621 taagtttcta taatagtttt ggttagagtc ggttggcata gattcaatat tgtcaaaacc 1921681 attaataccg acatctaatt ctactgtcac taatccttgg taaaacttct tataattctt 1921741 tttaattact ttgaaaaatt caacatcaaa gaagtcttca tattcagttg ctccactcca 1921801 agaatcataa gaggacttaa cacgataatt aaaaagaacc aaaactaact catctttcac 1921861 atcttttgat atttgctcca ttaattgatt tagtccttca ctggcattaa aatctacaat 1921921 gcttaatcgg aagtcaatcc aagtaacagc ttcatctttt aaccttcctt ctccgtcttc 1921981 attcacttca attaatacat atctgtcagc cataattccc tcctaattta tttgtttaaa 1922041 atcacgattt taactattta tgatccatta gtcacttcca aagcaacttc catttaactc 1922101 ataattaata tataaaatgt aaatggagtt gatatatttg aaccttcgaa aaattttatt 1922161 gagttctgct ttatcattag gtatgctggt atctgctgct cctgtcttgg caacaagttc 1922221 ttcgtctgaa gtgatagtaa aaagtgatga atatgattat gacaccatat atcagcttag 1922281 ccccctacca aacttcaagc cttctattga atacaatgga tatacttata ctctcacacg 1922341 ttattatttc gattactcaa ttcagtttta tacggctatt tatacaaaag ttgtttaaac 1922401 ttatagggag cttttttagc tcctttttca cctttttaag caagatattt ctttctatgc 1922461 ggtcttttat gtatgaaatc aaatgctttc cctaattcct tctcttctgt taccgctgag 1922521 tccatatctt atattgcatc taaggtttag tcagtcgaga tcattgaata tatagtactt 1922581 tactcagaac attttgctta ttaaggacat aataagtgtt cgtattaatt tttcctgtta 1922641 cgataacgat caaaaacaaa ataatttatc tcattttaag acagaagtta ttctgctttt 1922701 tcaaaaaaat attcttgatt ttcccttttt tagatgcatc cataaagcat tcgatcataa 1922761 ccattatatg taactgaaat gcaggtataa gagttattat atagggatta cactaccatt 1922821 atctgggggt gtattaacat ccaaatactc aaaagcaaga acaaatgtac ccatagcact 1922881 tccatttcca caccctatcc aaattttcat tttcctaatt ccacatcaaa atcacccttt 1922941 ttcacatcgt aatcactatc gtaaaagcct atagtatcaa cgtttttcct tcttaaaatt 1923001 ttcttttttt ataaatatct tcccaaaaca accactttcc cctactcccg cttatgtttt 1923061 acgatcgttt accccctatt tactaattaa agtatcaaaa attcttatgt ttactgtctt 1923121 tttagctcat tataaatttt tacgataagc aattgccttt gcttttggat atgacttgac 1923181 tgtatttggt gacgatttaa cagagaaatt taatgctctt ctgacttttt taactgcatt 1923241 gggcattatt gttgatccaa caactcaagg tatttctgat agtgaacaag caatggatta 1923301 tgattcaccg agataaaccc catacccttc tcttgattga ggagggtatt tttttcgttt 1923361 tttcaaatga aaaaattgca gaaaacttta catcctttta caattttttc aatgactatg 1923421 ttatgattgt tttcgagaga tttttgaaat tttcagaaag aggggtttaa atgagtaaga 1923481 tcgcttctga agttgtcgct actacactga atgactggta cattgctata aaaaaacaaa 1923541 aggttgatga atcaataaaa tattattcag agataaagaa actttttgat gaaatggaag 1923601 aagatcaaga agttcttgcg tattatagtc tattagaaga aagacataaa atgttgctgc 1923661 attcttcacg aggagagcct ttacaaaagc acacctattt tactgaagac aatcaaaact 1923721 tcataacaaa aacaaatgat aaattagaat acaactttta tttatttgaa gcaatgtacg 1923781 aggcatacaa caaaaactat gatcgagcaa ttaacctata tggattagct gagaaaaagc 1923841 ttgcagaaat tccagatgaa attgaagcag ctgaatttta ctctaaagtc tcttacttat 1923901 atactcttgt taaacaaagc attgtggcac aacattatat aaaaaatgca atttcaatat 1923961 ataagcgaca ccctgattat aaatgcaaac tagctacatc aacaatgatt gcagctgcaa 1924021 actatgctga tatgaaacga tttgaggaag cagaacaata ttacttagaa gcaattgata 1924081 ttgcaaaaga aacaaaagat gaatttttaa aagctcaatt atttcacaat cttagtatcg 1924141 tttattctga ttggaacaaa cctgataaat gcattgaatc tcttgaaaaa gcaataggaa 1924201 atgaatcttg gttacattcg atttattata taaattcttt attcatgatg attaaagaac 1924261 tctttaaaat tgacgaaaaa atgaaagcca ttaattttta caataaagca caggaaagac 1924321 tcatattaat ggagaataaa gtatacgaag ccaaaatcag catcctgtat aacctttatt 1924381 gtggggaatt aaaaaataat ttcaataatt gtattagtaa tattgagttt ttaaaacagc 1924441 aaaatgaact tgaaagtgta gatgaattgt cctacatagc tgcaaaaagg tttgaatcaa 1924501 taggtgcttt tgaagaagca acgagctttt tcaatgcgaa aatttgggct gaacagaaaa 1924561 tgaatcaggt ggagggaatc ttatgaaaaa acttgtgctt tgcgtatcta ttttagctgt 1924621 gattttaagt ggagtagctt taacgcaatt gagtacagat tcaccatcta acatccaggt 1924681 agctgaaagg ccagtcggag gttaaaaaag gttgattaat taatttagcc ctactcaaac 1924741 atttgagtgg gcttttattt tatgatttat gtccaccggt cagccctgct ctgtggagcg 1924801 cagtacctgc aaacgtaact gagatacttc tcactgtttt ttgcccgagt aaaacttatt 1924861 aaagaacatc aagcaacact tataaatatc catcgtgata tttgtgggaa aatcaattgt 1924921 tttggatcga tgaaaaccac cgccaagctc atctttactg tatccaattc ctagacttat 1924981 tgttcgacca actttattat atgtacgtgc ccttcttgcg acttcctcac aaatctccaa 1925041 gagcacagct ttaatctctt ctctctttgt ataatcccta aacaaaatct gactcttacc 1925101 aaaactaatc tgcccctgca tcaatggagc tcctatttca gataaatcaa ttccgtgagc 1925161 atgatagtac aactggtttc ccattattcc gaacttcttt tcaagcagct ctaaaggaaa 1925221 tttagctaac tgacctacag ttgatatacc cattcgattc agatttcttt ccatcctccc 1925281 tcctatcccc cacattttag acaaaggtcg aactttccag agtctatttg gcacatcttc 1925341 atatctccaa cgtgcaatac cactctttgt tttcttactc tccaggtcaa gtgcaagctt 1925401 actaagcaac atattgtcac caattccaac tgtgcacatc aaaccaaatt ctctccacat 1925461 gctgctttgg attgctttgg ccatttcttc aggattctct tttcctgcat ctaaaaaaga 1925521 ttaatcaatt gaatacgtgt ggacacattt ttcaggaaca aatctgtaaa acagctttgt 1925581 aatctcagtt gaaactctga tgaaaagctt catttgtgga tttacaatgt atattcttgg 1925641 atcttcaggt atctcaaata gtctcgatcc tgttttgatt ccaaaatctt ttttaagtgc 1925701 aggagatgca gctaacacta cacttccctg tctatccgta ttccctacaa cggcaagata 1925761 acatgttaaa ggattaagcc ccattgctac agccgataca gaagcataaa aggatttcat 1925821 atcgacacag agtatattct cacgtggaaa ttgtgagtaa tcagtcattg tatataactc 1925881 ttatgatgtt attcatgttg atataaactg tattgtcgtt ctggtctttt acgtgaagct 1925941 tttgttgttc aaaattaatg taatgtactc tgccggtaac attttcaaca aatcccttgt 1926001 taaagagttt gaatttcaac tctttattaa attccaatgc ctcagaaacg agaatatcca 1926061 tctcatcaat ttgtttgtca tctaaagatg gcttttcaac ttttgatcca tcaatcaaat 1926121 cttgtttaag ctgtattaat tgttctagca tcattgatgt ccattgatag ttcctcgatc 1926181 cctaaacata tcgactcact ccttgattga tctaatatca acagaacaaa cgttccttat 1926241 tcaatataga tcagaacaaa agttcgatgt aaatgttggt aataaaatat aaaggtcaat 1926301 aatgatatcc gtagtattaa taaaggagag attcttttcg acgagggaga gtgtgatggt 1926361 gaatgaagaa gaggttaatt ggatttttgg tcttagttcc tgctttgatt atgtggggta 1926421 taactttaat cgaatcaaac aaaaagaccc ctgtagaagt tttagaaagt gcttgggatg 1926481 aatttgggtt atttagtttt gaaattggaa taacagatcc ggcaattaca ataggcatgg 1926541 atcaaaccaa aagtgaagca aaactccgtg aatatttaaa agataatctg tctagagaag 1926601 ccaaggaaaa atataagatt tatatattca aggatgatac tgataagctg gagaaagagc 1926661 atcaagaata tttgaaagaa aataatctca ataagtaaaa cgcccagcaa ttaaaactgg 1926721 acgttaaaaa acattagtta ttctttattt ttttttagta ttcacacgta atctctctct 1926781 atcttcttta aaagaggata tgtagttttt agactctaat gcagtcacca acgctttatt 1926841 agttctatta tttgagatct ttattcgtct gcctttttca gcaatttcag agtaaggttc 1926901 ccctatttta gttaaaaatt cagtaattga ttcattatca atatgcttta tttgtccagc 1926961 tagcaacgat aacctagtat ccaatgttgt aggtgattca agcaaaaagg ttagtagttc 1927021 attggtgatt ttcaggttat gctcattaat aaaataaatt gtatctttaa gaatatcatt 1927081 atttccatct gtcaaacagt tagaatttaa atgttgtaca aatatttctt tgttaaattg 1927141 agagagctcg ttgctatcta tgagttgctt tatatcattg gcatcaaggg aaaaatcacc 1927201 ttgtttatca ataaactcgt cagggtttct caaagcgagt tggatatgaa gtgtatcaaa 1927261 atttaatttt aactctttaa aattttccgg tgttagagat aacaaatcat tatcaatcaa 1927321 taattttgct cttttttcac taacatttcc gagcggaaag taaatccaac tttgaatact 1927381 agcaattaac acttcgaatg tttcgtctgt aatatcccga ctattaatga tttcttctga 1927441 gatatcttct aaaatcgctt cgtcaaattt atcatcaaac gcctctatat tatttttaga 1927501 gagctctttt ctattaacag gattgtttaa gaaagctatt aagaaatcag gcattttttt 1927561 attgtattct acataagaag taataacgtt tgaccagcat gcaaccattt tattttcacg 1927621 gatcacaatt ggccataact ctttaatcaa ttcaccaata tccgagatgg caaaagtttt 1927681 tttcatgatc attgcatgct ttactctctt atctaaatcc tcccgattta ataactccag 1927741 aaaactttcc tctggttcct caatctcctc agtaagtaaa actttttcaa caaatatatc 1927801 aatattgtca tttacgtaat tgataacagc ctgctgatca gagtttttaa ctgcagcata 1927861 cgttatattg ggagcatcat ttaaaataac tgataaagtt ttgatattaa tttcgtatag 1927921 atttcgttga acaacaaagt catatattgt ttcagaattt agcaaatgat ccaaactttt 1927981 aaatttaact tggagtttta atagtagttc ttttattttc tcctcatcag atactaagct 1928041 gagaagattt aagtacttgg ataatgtgaa agacatgacc gactctttat tcattcggat 1928101 aatatcagct atatcagcat atgtaagtat atctgacaag tattcctctt ttttctgttg 1928161 tgtataattg gatctaagtt caataaaact ccaaaaatca tcccatttac tagatatcga 1928221 ttggataaag gcagctttat ttattgccct ttctttaaaa ccatctatga atgtaacaga 1928281 ttctttactt ccatttgcaa gtcgctcaat tatgctatca taataattac ggtattcaga 1928341 atgatccatt atatagttta agagatgaaa attaagtacc tctatttgct taaattcagc 1928401 accaactaat ttgctcatta ttttaccgat attatccagc tcaaagctgt aaggcaatga 1928461 ctcgtggttt ttaatactaa atacaaattt aatatcggaa agacttaaac tttctggata 1928521 gaagtaagtg atgtaatggt tatacatttc atcaatatat ccatgacgta gcaggtaaac 1928581 aagtaatttt ttctcgtaaa gcttatcaga aaatacatcc tttgaattca tttttgtaat 1928641 taatacttgt aaagattgcg ctcttatttc ttgcttttct ctctctaatt ccaatagttc 1928701 tttcttgaat ttttggattt catttttctc tatagccttg atggcatctt ctctttcaaa 1928761 gtagttcggt ttccgaccaa aaacagttgc aatttcttta attgtcgctg gaccatttct 1928821 atttcttaaa taacaataga tagtatccgc attttttaac ttctcaaaaa accgatcttt 1928881 attagatgta ttgcctctaa atacctcgcc atctatatta atatcataat tagaattcaa 1928941 atttgatatt tctaattcgc tcaagtatat aaaatttaat tcagcaattg attttaaaga 1929001 ctcaacttct atattcgcta atttcctctc taattgttgt attttagcat taattaattt 1929061 tatttgttcc tcaattataa gttgtttttt ttgaaagatt tcatatacca accctttgtt 1929121 atattgtaat ttagaaaaat ccacaggata aatatttttg tagattatca ttgctaacat 1929181 tttgttagga tcaagatcaa ttgcacttag tttttgttgg tatataacaa attcattaaa 1929241 aatattcttt aatactctca tgtcatcaat gtaaattgtt acatcctcta agaaatgagt 1929301 gtttatcaaa tcagaatatg gtgaatgttt tattttcttt ttaagtatgt ctcctgaatt 1929361 agatgcatta ataattggta ttactgggat aataaaatca aaaaattttg tgcggtctct 1929421 agttaacttt tcagtgtctg catctccaaa aatatcatct tttatcgcat atataaaaac 1929481 aacacgtcta tctatttgtt ctgaattatt tataagttca tttaattctc ttaatctttc 1929541 aaaaatacct atattattaa agcgatctaa gtcctcaaat attacaacat tatacttgga 1929601 ggcttcaaaa aaatataata tttcatctaa atatttatca aatatagaag agttttcttc 1929661 ccctgtattt ttttctaacg ttgtattagc aattgtaacc ttattcaatt ttaagttggc 1929721 acggacaaaa tgataaattc ttttatatgc gagtagagga tatactataa agaacagtgc 1929781 taataatata gtcagtcgta tttgttgctg atcttcagta ccgagactcc ttgaaactaa 1929841 cgtctcagca tatattcctt taagtgcatc aggtttaaaa aggtagatgc caactataat 1929901 aaatgcaaaa aagaaaatca aatttataat tatgctctta gtccttatat gcttaattct 1929961 tttaaaccta gaaaagggaa tggttctatc gtgtacccgg tatatcattt gttgcaagat 1930021 gcttttctct aacttattct ccatatcatc cgtatctgtg ttgaatgtag ctaaggatat 1930081 atttaagaaa ctatattccc tgctgtattg tttttgaaag gtatttaata tgctactttt 1930141 tccagacccg tagggaccag ttagggcgat atttttcact tttttatttt ctaaccccca 1930201 acttagtgct ttagaatatt ttccatcagt gtcgacatca ttgctaggag aaagatcttc 1930261 aaaaaggctt tcttccttaa cattaggttc ttttagtcta atcagaagtt tctctaacca 1930321 ctgcacaaat ttttttttga tttcccccaa aaaaaacaaa tcctttctaa actttcaggt 1930381 gtaatacgaa ttaataaaac tggagcaaag aactaaataa atgagtatgt agcaatgaca 1930441 aatcatttct cttccatcta atatagtcct ttatcgccag ttgaaattca ctattaattg 1930501 taacatgaaa gggcattaaa agtttctgaa aaaaagatga tcaataaaca acacagcgcc 1930561 caattacagg actgtttcat atttaaattg aatttttata agcattaatt gcttcatttc 1930621 gcagcagcat attatctttg ttaaccatgc ctaagttgta agcttttttg ataatatcta 1930681 atacctgaga atctaacgcc gaaagattac cgcctggatt aaatcttgat ttccaataat 1930741 ctaaagaatt atttaggtca agtgagcttt ttttgttctc gggtttaact acttcatttt 1930801 tctcaagtgt ttcacagaat tcactaaaac caatggatct actgggagct gagttatttc 1930861 ccccgtatcc ttctgtagcc aagctgcaaa atgctaagaa ttttggatca taaataagat 1930921 cgcttcagtt tacatttacc actgataatc acaatcctct caaagctttt tataattgta 1930981 gcaccttttc catttttaca catattaaat atcgacaatc attcaaatga tttaataatt 1931041 gaatacaaaa aagaacctgc attttgcaag ttcctttcac gttgtcaata tattgtgaat 1931101 ttttaacgac aagggcattt atgtatagta tgatatttcc tgtacagtaa gttttgctca 1931161 ctcgagggag tcttgctcat cccctaatga aaggggtgat gctatgtcaa cattccaggc 1931221 attaatgcta atgcttgcaa tcgggtcgtt tataatcgcc ctattgacgt atatagaaaa 1931281 aatagacctc ccttgagcct cagaacctga agggataggc ctacctagaa ccacatcgag 1931341 caagcccttt gatgggcaac tttttgtaca gagccggggt gttggtagca cctcggtctt 1931401 ttttatttta tgcatttctc attaaagaaa tgcactgtaa tgtattgtaa aactgattat 1931461 aacacatttt ccgtgaaatg cattacaata aacctcaaga gacttggaaa gcttttttat 1931521 tgtttcttgt aacgttataa tgatctaaaa tagcgcacaa gcctttatac atcttcatca 1931581 tttcttactc ttctagctcg tctttcaaca ttccaattcc caatctttcc ccagacattc 1931641 ttgttagtcc atttccctag cttagtttta tcaaaccatt cctgaaacaa agatatttca 1931701 tctttccttt gcattgtatc ttttaaaagg aaataatgta ttatccaaaa gatataaaga 1931761 gctgaacaag aaagtccaaa aataagttta tttacctcta accaatttcc taaaacttgt 1931821 tcgcctaaat atttatcata tagaaggggt ataaaagcaa atgctgaagc accgacaaaa 1931881 aaagctagag tttctttaaa ccatctaaca aaaacaaaaa cagcgcttaa aatataattc 1931941 gttctaaaaa gaactttata ccaattataa ttcttgttta gagtaacaaa tatacttcta 1932001 tattctttat taactgcttg atctaacatt ctcattttat aaaataattt tttcctattc 1932061 tcgctgttct tgtttaaaat atactctctg aaacaatctt ctgtattcaa aatttgatct 1932121 atcaataaga tgtttctaag ttttgatagc ttcccctttt tcccactata ttcttcgaaa 1932181 aatttttcta taaggaccat tttatggttt tcatcttctt cattctttat ttcttttagg 1932241 gaataataca taggctctaa aattttttct aatgtttcac ctgattgaga gtagaatcgt 1932301 tctatacttt tttgtctttg attgaatagc aatgcaacta tacccgtaat tactgcagta 1932361 agaataccat tttgttgtat ccaattccaa atatctaata actccaatta agcttctccc 1932421 cttctctctg aatttacttt taatacgggc taaaataaaa aaggtttcat ataaaacggg 1932481 actagaaaac ttctgtcact ttaattattt aatccaataa aataagctct cattgcgaga 1932541 gcttatttta tttagattga ggatgtgcaa ctcaagcctt ctattgcgct atagcaatac 1932601 ttttgcttaa tcgtcccagt cttcatcctc atcccagtca tctttcgctt cctgaatctt 1932661 attataaaaa aattcaataa agctgtctgc aacagtatct tgataaccaa ttaccctatc 1932721 ccattcaact acagggcatt ctccgtcttt cattttattt gtatctagac agtaagcaaa 1932781 gtaatcaaca tcttcaataa ccacaagtcc atcagtaagg ccatagtgtt ctttatattc 1932841 attagttcta tttacaactg atgcatgatc aaagttgtag cctaaaacca aaacgccgaa 1932901 taaaccacca gcaccgtatt tttctaaaaa ccatttataa ctgttgggga gatcgcattg 1932961 gaggttttct tcaatgcgac caatgttttc atgacttgca ccttctgtaa atatagcatt 1933021 ttgtttattt tcattaataa agttctcaac cttcgaataa atcatataaa cacctcaatt 1933081 ctcattttca aattgtttcg ctctccattt ccaatatctc tttctaaagc tctcgtattg 1933141 tgcttttaaa accttatcat ttctaaaact ttcaccatca gacttaagct gatgaatgac 1933201 atcactatat tttgtatgta agctgttcgg gatttcaagc attgggccag gttcttcttg 1933261 aatcaagtga tgtaaattaa tctgtgtacc gtcttttgca taaggggcat tcccgttttt 1933321 cattagctga agatttgtaa caccgaattc tgttttttga ttaatatcaa tatctttcat 1933381 agtatacact ctacggctta catctttaac tttccccttc gcctttacct tcccctctat 1933441 ttcatatgca tcatactttt ctttatttag ccaaggaggg cttttctttt ggccagtaaa 1933501 cggttttctt gttccatccg gtattttctt cgcattagtc aaaagttcat tcttaaggtt 1933561 ttggctatca accacattgt atggcacgtt atctgctaga gcaagcttat acttagggtt 1933621 gtaaggcagc aaatctggaa tcttaacgtc cttgattttc ttacctgctt gacttgcttt 1933681 atttattacc ttgcccgctg catctgcttt gttaatggct cctgcacctt ttgtaccaac 1933741 aacagctaca gccactgaac caatagcata ggtaacccat cttgatctag aataggcatc 1933801 tccattcacc atatcctttt gatatgactc ttctattgct gctgaaatgg catcgtatgt 1933861 tttcactgga tgcatagctg cattacccag tgctgagagt gtttctcctg gatcggtgat 1933921 gaagtcccat atgccggtta cagtgtcttt tcctacatcg tataaaccaa ctcctacacc 1933981 ttttacgata tcccaggtga tttctcctgc tccttctagc tgcttcgctt gttcaatttg 1934041 cactgcaagc tgcacttgag ttggctccag attctcgtac cctactttct tagcaatctc 1934101 taaatattca tcagggtcag atacaccgtc attaagtttt ttctttaatt ccttgatttc 1934161 acgttccttt gcttcttctt tcttcacact taagtaagct tcagaatgct tttcaatatc 1934221 gccttttttc ttatgtatgt cactttctct gtacgcttta gcgttatagt gaattggtgt 1934281 agcgtttttt cctttgcctg ttgattcctg cagcttttta aagtcttgct gaataaattg 1934341 ttcgtttggt tctgtttcag cgtattctgt ttttaaatcc tcatcaagct tgtttagctt 1934401 atcgattgtt ttttcacgtt tgtcatctgc agaagaaagt ttgtctttga agtcttctgt 1934461 tgagaatatt tcaaggggaa ggatatcatt gatgttgttt aatatgtctt tcattgcttt 1934521 tttctgttca gacataatgg attttgattt tgcataagcg ttagccaact cgtgttctag 1934581 aaaggattct tctatgtaag catcagacat cttcgcatct tcaagtgttg cagacatgct 1934641 gcttaagaaa gcaatcttca tatcgataag atcaatccat tggtctgtta cgccgacatg 1934701 accatgataa aatgctttaa tgttgtcagc acccttgcct gaaaattcac tgtcatctag 1934761 gttagctact tccttaaacg cttttttgag cttcaccatt tgcgacctta gttccttata 1934821 ctctttggtt cttttatccg cttcaaagag taatgaatca gcctcaaata ccttcatatc 1934881 attctccttc ctagactact tctatgtaaa ttttaccaca gtaatctaat tgaataacag 1934941 aaaaagacag ccaaaatgac tgtcttatac atcacacact atcttgttct ataataattt 1935001 tctgcggtat agtagcgcca atcccaaaaa ggttccccat tggccaatat ataccggtct 1935061 aaaaattttt caaagtttaa atttaatgga ttatattcta aaccactttc aaatatatag 1935121 agatagttgg gatcaccttg gttcacttta tctttatcga tcattaaatg gcattcttcc 1935181 aataagtagc caattggaat accattgata tcttcaaaca aatcttcata ttttaactcc 1935241 tcttcaatct cttcaaggct aaatagctga agtcctccac ctatattctc cccatcagaa 1935301 agaatctcaa aaattttcgc accgttatgt agtgtcatga acttctgata atcctgtgga 1935361 agggtaagct ggtgtttagc ctcaaagctt tgaatgtcat tcagggttgc tttgtcctgt 1935421 gaaaaagtaa caaggaactc catgatatca ccttctgaac aaaacaattt aatggctcct 1935481 ttttcgtcta aaagactttt caagccattt acagtcttat gaacaaagtt agtcacatac 1935541 atcacccctt tatttccttt taacaataac ctttcaaatt ccaaaagatg tgaacagatc 1935601 gtgataggtg ctcttttcag tgaatataat gcaataaatt ctaaaaagag gtgcctccaa 1935661 aaattgaatt ctctaatgaa tgatgacatg gtaaagatca ttagaaatgg ccttagcgca 1935721 tcgcagcatc caaagcacat tcttgttata ggagctggat tgtccgggct tgtatcagca 1935781 tctttgttga aaaatgccgg tcacagagta acgattctcg aagcgagcgg cagagcgggc 1935841 ggccgtgtct gcactttgag atctcccttt agtgatgatt tgtatttcaa cgctggcccg 1935901 atgcgcatac cgaataacca ttcgttaacc ttagaatata tcaaaaaatt caaattgcca 1935961 acaaatgtat ttatcaacag aaccccgatg gacatcattt atgcaaatgg aatcaaaaca 1936021 cgtctccaag tttttgaacg agctcctgga atattgagat atccagttgc accaaatgaa 1936081 caagggaaaa cgtctgaaga gctgatgctt tctttactgc agcctattct aaattttatc 1936141 aatcaaaatc cagcaagaaa ttggcggatt gtcgaagaac aatacaaaaa tcattcgtta 1936201 agctcttttt taaacacgta tttttcatat ggcgcgatcg atatgatcgg tgtacttttg 1936261 gatatggaag cgtatatggg gatgtccctt gttgaagtat tgcgggaatc tatctttttt 1936321 tcatcccccg ctcacttcta tgagataact ggcggtatgg atctgctgcc tcacgcgttt 1936381 cttcctcaat taaaaacaaa cattctatac catcaaaaaa tgatgaaaat gtctcagggt 1936441 gaaaatcgtg ttacgatcca ttgtcagcat caacaaacgg cagaattcac atcattcaca 1936501 gctgatctcg ctattgtaac cattcctttt tcaacattgc gatttgtaaa agtcgaacca 1936561 taccattcat tctcttacta taaacggagg gccatccgtg agctaaacta tatcagtgca 1936621 acaaaaatcg gcatagagtt taaaagccga ttttgggaaa aagccggtca gcacggcggc 1936681 aaatctatta ctgatcttcc gattcgtttt tcatattatc caagcagaaa tattggagca 1936741 aatggacatg ctgtcattct ggccagctat acatgggccg atgaggcact gatatgggac 1936801 agtctttcag aaggagagcg aatccagtat actttactga atttatctga aatctatggt 1936861 gatattgtgt ggtctgaatt tgtgtctggc acttctttta gctggagcca gtacccgtat 1936921 tctgcgggag gttttacagc tttcgaacca ggacaagaat tagagctgta tccctatatt 1936981 cctgtccctg agggcagagt tcatttcgcc ggagaacacg cctcactcac tcatgcgtgg 1937041 atgcaaggcg cgattgaatc tggaatacgt gttgcttatg aggtcaatcg cttaccttag 1937101 atcatgctca catcttgtta aaactggttg atataaaaag aagtgaagaa tttatactcc 1937161 tttgtttaaa agattaattc aaatatggga tgtctcaaca ttcggttctt tattatcttt 1937221 atacacgttt tgaatgcgga cctccctttt cttccataat cattaataaa tacccaacca 1937281 taggaaacgt tttaattaac catcgggcga actttctttc actgtataac gattcttaat 1937341 gttgcttttt atcctttact tgtcctctct ttttttcatt gacttacatt tcttgaaaac 1937401 cagtataaat cctaaaggaa ttttgtaaca aatacagaat tggaaagaga agcgccaaaa 1937461 gaaatgctaa ctccttatct caaagacaaa actgcgctta tattaaaaga aagaggtgtc 1937521 tttagaatgg ttcattttaa aaactgccct gatccttctc taaacgccaa ttctcagtct 1937581 caccccgaat tttcatccga attagaacat attaagacaa gaatgcaaaa ctttattaag 1937641 cactcggtta cagaccaaaa tatcgaagtt actgacgcaa gggtgacggc cgaaggagag 1937701 gtcacctctc ttttaaaaga acgtctcgac aaggaatatt ataggctttt atctaaaatc 1937761 acccgggaag taaatgtggc tgacttcggc gctgttccag atggaagaga caatactgaa 1937821 gcttttcgaa aagcaatcgg gaatggccga gtcaaagtac atgttccagc gggagaatac 1937881 ctcgttcaag ggattaaact tccatcttgg acaacaattg ttggacaagg taaagggatc 1937941 acagtgatta aattgcatga agacactcca gcgcatgaat gggtgattac aaatgatgat 1938001 tatcaaaatg gaaatcgcaa tatttttgtc caaggaatgt cattagactg gaatccaagt 1938061 agacaatgcg gtgtgagaaa tccaggggga cagttctcca gttgtttaac ttttgctaag 1938121 gttgaatatg ggtggatcaa agatgtggaa gcgattaacg caggtcttca tggtattgat 1938181 attacatcgc caacgtatga ccatttgcct gataccgatt ggacaaaaga cggatcaaga 1938241 tatatttgga tcgataactg tgtgacatat ggttcaggag acgacggcat taccacccat 1938301 tatagcgaat acatctttat ttcaaactgc cattcaggaa atccgcgggg aacagaattt 1938361 gctgaaggtg tttcaaactc caacggaata gaaattgacg acggctctag gcatgtgtgg 1938421 cttttgaata actttacaag cggcaacatc cgcggagttg aagtaaaagc ccatgaactg 1938481 tggccagcct ctcaaaacgt ccatatcata ggccatattt cttatcgcga tgttcgtgca 1938541 tttgatcttc gtcatattgg tcaccatcaa attacagatc ctgaaagcac aacagcatac 1938601 gatgtcacac tcattgattg ttcagcagtt gaaccagttt tcaactcgct ttacgatgct 1938661 gtgaccccaa gagcgctggt tatttcggca tataaaaacg ttaatgtaag cggattcaca 1938721 gcgattggtg atccagacta tgattataaa gaaaaccctg tcgtagcctt gcaatatcgc 1938781 agccaaaata taaccattaa tggtattaaa attcgcggtt ttaaaaaagc cggtgttgat 1938841 attaatttat caggcggatc aaataaaact gattatatta aaatttcaaa ttttgatatt 1938901 tataaatctg ctccaaaagg aatttcaatc ggtggaggcc tctacaatgt caatattcta 1938961 aatggaacga tgattactga caatgggaca gttgcaattc agtcccccaa taatcaggcc 1939021 acaattctcg gtgtacaatc agaaggttat agtgtggcag cctcaatcaa aggccaaaca 1939081 taccaacaag ttccaatcaa tttgaaagga ggcatacagc ttgcaacgac ctctggcttt 1939141 gccgttaacc aaacaagcgc agttatagca ggtaccggcg acattacggc ccgcggagaa 1939201 agaaatgcgg tcattagctc ttctggaggc tccagtactg aaggctctcg cgcattaatc 1939261 gcttcttcaa ataacgcaca tattagagga aaccaagcgt caagaacaat actgtcttct 1939321 gaaaatatta tacttgagga accatacacc gtggcaggag gtcatcaatc aataaagtgg 1939381 cttcttgact ctgttcgggg aaacgggacg tttgccggtg caatcagttc ttctttaggt 1939441 ggatatggag agtattttga gagttcaact ggacagttaa tccatactgg tacaatcgtg 1939501 actttaagag gtgaaaaaat tgtgcccgcg aatgttggag attatatgct tggcgttatt 1939561 tcagaaactt cagctttcat ttcaggagcc tccagtttcg tctggcaggg ccgttatttg 1939621 acaaatgagt tcggcggatt tatttatgaa acggtgactg atgaggaaag cggtgaactc 1939681 atacgtgttc ccaaacaaaa tccagactac gatacagcgc tggaggcaaa ttatcattca 1939741 cgggcagcaa gagacgaatg gcacgttgta gggttggttg gccaacatta tgtgcgtatt 1939801 gacgaaactg tcaatcaagg agattatctt acggcacata atggaatagg aacaaaagcc 1939861 actgaaggaa gctggaaagt aatgaaaata acctctgctt acacatcaga aaaagggtat 1939921 ggtatcgctc taaccgtcat caaatagtgg atacgccgac cagttcaata tatgtttatc 1939981 caaataatta gatctctttt ctaggttctt tattccttgt atgttattat caattttcaa 1940041 tatctaccaa aataccccta atatactatc gtaattaact tatattataa tcaaaaaaat 1940101 tttgacagct gttccttctc gttattcatg aaagttgcta ttgaaatgag taaatggata 1940161 tcatattaga cttctatagc aaatacacca tatatatcct ttaagtattt acaaattgaa 1940221 aatgtttcat gaggcttatt aaaagtattg ttcttttatc atctgtaagt cgatacaaac 1940281 tgcattaaga tcacacctaa atctcactga gttttttctt acaaataaaa tgaaaaccct 1940341 ttccattcta aattcatttc accgttacta aaagtaatcc ttgcattcct tcgccctcca 1940401 tgctatattc atatagcgat gagctgaatt gtgtaagccg atgtacatgc ctttacggca 1940461 cacacgaatg tggcgtgtgg tgcatcgcct caatacgcaa agacgtttgc cttaggcaaa 1940521 cgtctttttt tgcgttatcc gatttttgtg ccgtttggga caggctgatc cggctgcaaa 1940581 aggacgacgt cgccctggcc gggtatgccg ccgaggacca agacttccga tttaaatccg 1940641 gcgatccggc ggggcggaaa gttcacgact gctatgactt gcttgttgat gagaccttcc 1940701 ggcttgtaac gcttcgtgat ttgtgcgctc gattgtttta tgccgatttc agtcccaaaa 1940761 tctatcacaa gcttgattgc cggtactctt gcttcaggaa attcttccgc ttttacaatt 1940821 gttcccgttc tgatatccaa tttctcaaag tcatcaataa ctgccatatc aataactcct 1940881 ttttctccta ttgtaaagga gatatacaat attcttttaa ctaaagagcc atcatttttt 1940941 atccgaatat aaggtgtttc gatacaggcg gggcggcatt cctgtgcttt tcgtgaacca 1941001 tcttgtaaaa gaagaaaggt tttgaaagcc cagcgcctcg ctcacgacgg taagagtttc 1941061 atttctctcc atcagcattc tttttgcttc ctcaaggcga aggtcggcaa tatagttctg 1941121 cggggacttc cctgtctgtt ttttgaacca gcttgaatag taagctgggt gataatgctc 1941181 gatttctgcc agcttcttaa tcgtcagccg ctcaaataaa tggctgtgaa tgtatgcaat 1941241 tgaggcatag ctatgggatt gaagcttttc ttttatgtat tgtactagca tatgaagcga 1941301 gttggctgtt ccggcctttg cttcctctgt cagcaagtac ctgatcgaag accagaaagg 1941361 atcgagggca gcttcaattc ctgatcctgc acgatactca tcaattttca ttgcatgaag 1941421 cggaacatcc agtacaagac attcatttct tccgatagaa cggaagcgat gctcgcactg 1941481 cggcggaata tataaaaaat gatccggatt taatttcacc tggcgcccct cagtctcaag 1941541 atcaatactc ccttcaagcg gaaaaagaaa ttggctgtac gcgtgcttat gtgaatgata 1941601 tagccgtgtg tatgtccgtt tttcgcaaat tatctcttga agcgagtcca ttagcaaacc 1941661 ccttcctttg gtcatctttt aatccggtaa tggtgttccg atataggcga aaagccgatt 1941721 tttccatata aagaaactgc cgccagattt tctttcatca cttgtaaaaa catgcgttcc 1941781 gctccgttgt tttttgccca ttcagtcaac accctgatca cttgggttcc tgcccctttt 1941841 cctctgtgct cctcagctac aacgatatta ctaagtccgc cataaccatc aatgacagaa 1941901 accgtgccaa gcgctgtcag gctttctttg tcatacatct tgaaaaaagt tttacacggc 1941961 ggcatgcgtt cgaatatgtg tttgtaacct ttgtgacgct cgggtgaaaa cccttctaat 1942021 tgaataaatt catctatcca aacagatgat ggctcttgtt cccacttgta tgtaaatcgg 1942081 ctgttgtcat ttgttcggct cataattgac cggcacaacg ctgtcatctg gaagcactcg 1942141 tctacctttt cataacggct gtctgccaat gcgtcatcaa gccctttcgg tgatgcgttg 1942201 ctaatatgaa aacaaacagg taagcctaaa ctttgataaa aaagttcggc ctctagctga 1942261 aaatcccctt caggcatatc cgcagacgtc catacgctat ttgccctttt ggttacgcca 1942321 aaattcgctc tgagaagcca tttccctatg cttttttgaa aataagccgg ccatgaagct 1942381 gccgctaatc gttcaatctt gcgaatgtca tccattgcat aatgcctctc ccctatgtat 1942441 actcccttga tattatacaa tattcagaaa tataagacat ccatttattt gtttacataa 1942501 tatttttatt gtttattaat aatcctgaca aaaatgtccg aattgaaaat gacaggcttt 1942561 ctaaaatgtc ctcctcacgt tcaaatgctt cttttgcgat taaaacagta aagccatgca 1942621 gcagacttct gagccccctt gtcgcatgaa tggcagtctt ttcacttgca tagccgtttt 1942681 caatgagcag cttcgtcaca agacagacaa tttggtcaga gacgatttcc gtccgtttgt 1942741 cgtgaacctt aagaagagcc gcttcataat atccgggatt ttcaattgca aaatcaacat 1942801 atgcatgagc taaagaaagc atcgcggaat ctccctttcg ttcggttacg gagtccgcca 1942861 tttgatcaaa aagctttgtc agtcctctga cagcaagttc tgctctgatc gcttgcagcc 1942921 cgttgatatg gttatacaat gacggggggc gaacattcat ttttttagaa agtgcagcaa 1942981 gtgagacacc atttacccct tcctgatcgg caatctctgc tgcagcgtct acaatcattt 1943041 tttgggtcaa acctattctc ggtgacatgc tcatcatcct ttctttgctt tttggatcgc 1943101 ctgtctcatc cgctctgaag gtgatcgcag gaattttcca tgtccgacag cgagacagga 1943161 aggcgcctta tcggcgagca attgtgcact tttgatggcc tcctccttat tccatgtggc 1943221 gaaagcggga aaaggaaacg cccattttat ctgacctgat acagcgattc ctccgcgcaa 1943281 ctgaaacgca tctcctgcta ttaaagtgcc gtttcttgta tcaagaaatg acatgctgcc 1943341 cggtgtatgg cccggtgttg gaatggcaag cagagaacca attgtttcac cgcccgtcag 1943401 cagttggtga ggctttgttt gtatgtgttt cggaatacct ccttttatag gcgtctgcgg 1943461 ctcatcttgc cgcaaagatg tgtcaccttg gagcaagaat gaatcccgtt ccgagatcat 1943521 gacctttgca tgcggaaatg tttgtgccaa tgtatccagt gatccgacat ggtccccatg 1943581 tgcatgagtc agtaaaatat gctgaagcgg ttttccaagc tgattcacag cttgaataat 1943641 ccctttatag ctgcctggca gtgcggcatc aataagggtg acttcgtttt cttcctctac 1943701 taaatagcaa ttaaccggaa acaatgctgg aaaaaaagtc agctgccaaa ccgtttggta 1943761 ctgagtaatt ctcatctttt tattcctcct aacaaaaact aatggtgtta gttttattat 1943821 taactaacac cattagtttt tcaagagttt attatttttt tatcgctaca taaatgttaa 1943881 cttgtgctcg ctgtggcact gcggcatttt gatcatacat ctcaaagtca cctgtaaacg 1943941 tgcgcagatg ccgcttatcc caagtccaaa tttccttcca cgtttcaagc acaatctctt 1944001 caataggacc gattctggaa gtgaaaacgg cgtaagcgga agccggcaaa tcaatatttt 1944061 catatggtcc cggaagaatg tcgtcgtatt cctgaaacgt tccgactgaa aacgtataaa 1944121 acccattcgt ctcttgttca taattcgaat ataaggcaat aatgctcttg tctttttcag 1944181 cctgtgataa aagagcgctc atatcctgct tccataattg atcccacagt gccggaatcc 1944241 tcctttcttc cgtcatttcc agtgcgttgc ttgtccgttg tgatagtccg gcaaatcgtt 1944301 tcaggtctaa gtgtgttata tgtgaaaagc ccatacgatc tcctcctttt tttaagatta 1944361 tagacaaaga aacctgacag cagtgtgtca ggtttcatat attttttgca tgtgatgaat 1944421 ggtttctttt actttatccc ttatatgaag aggctgcaga acctcaatat cctttccgaa 1944481 ctggagcaaa aaaccgatca gccattgatc ttctggaagt gaaatcaccg cctggcagat 1944541 ttcatcttcc tcacaacagt gaaggacatc atatccgaac cattcaccta tacgctgacg 1944601 tgctgacggc tgaacaagaa taaccaattc agttaaacgg tccttttggt accaactctt 1944661 atcccatggc aaagtgtcca gctgaatgtc ttttctgata aatgtctgat gtaagatggc 1944721 cagatctttc atccggttca gtttaaaaaa gcgaaaatca tttcttacca ggcagtaggc 1944781 atataaatac cagtgccccg ccttgcaaac caatgtataa ggttcagttt cccgaagtag 1944841 tgtttccccg cttgcgcttg tatatgtaaa agatatcgtt aacaaccgat cgatggcagc 1944901 gctgattttc tcgcgcagcg tcttttgatc ctcagtatgg ccccaagccg tcatgtcaat 1944961 aaaccatttt tctgtttggt gcttaaatgc ttgagtagat tgctcaggta taaggtgttt 1945021 gattttttga taggctgtgc tgtgagaaac gggttcatac atagatgaaa cgctttgcaa 1945081 agcggaagca attgcaaaca attcctcctc cttcagccac tctctttcaa gccgatacgt 1945141 ttccatgatg ccaattccgc ccccggaacc ctgtgaggtc acaatcggaa taccagccct 1945201 attgatcgtc tcaatatcac ggtaaattgt tctgacagat acttcaaaca gctcagcaag 1945261 ctctgcagcc tgcacttgtt ttttgctgat caataacaca accatcgcta acaaacgttc 1945321 cagtttcatt ctgcgcacct tttcttcttg tattttccaa caaaacaatc ataacatttt 1945381 gataaagctt gggcatatct attatgcggc ggaatacacc tcgcatatgc tatgaaaaca 1945441 ggggtttccc cttctttttt gtgttcagta tttatttcag ctactatttc cgaccggata 1945501 agcatacact tctcaacgga ggggatttca catcatgcat cttacacttc agagcgttta 1945561 tcctgccata atcatcatct tttttctgta taaaaaaatt aaaaggtcca tcggatacca 1945621 gccgctgaag ccccgctggc tgttcacccg tatcattctt ttctcgctgt ttgcttttgg 1945681 actttcaatc ttcagcgcca ttcacccttt tttatatgga tatctcattt tgggcattct 1945741 tggcggatgg ctccttgtct ttttcgctaa gaaaaacatc tcttttgaaa aacgcagagg 1945801 aaagatctat tttcggactc atatttgggt agaggtgatt ctcttaactt tatttctatc 1945861 aagatttctg tatcgagtga cggagcttta tcttacctca cctgatctaa accgccttgg 1945921 atcatacagt cagtcaatcg gaacggaccc tctgacaatt ggcgtctgtt ttctgatagc 1945981 cgtttattat atcggttttt cttcttttat catcaagctc agcagaaacg aacttgaaca 1946041 gcacgaatac aataaagaaa aagacatcct tgcccgctaa cagcgagtta agcaaggatg 1946101 tctttttcaa tcatgctgtg tatgatggat catttgctga agaacatcta aaacatgttc 1946161 atcctccgga gagtaataaa tcgatgttcc ttctctgcgc gatttgacaa gccggagatt 1946221 ttttaaaaat ctaagctggt gggacacagt ggattgcagt aaattcagct tttctgcaat 1946281 tccgtttact gcatgctcac cttgggacaa taaatggaga attctgattc gggtaggatc 1946341 tgaaagcgct ttgaatgttt gcgcgactag aaacagcgtc tcctcgtcca gatcagcagc 1946401 cgattgttcc gtttctctaa attcagtcat atgtatcacc tttctttatt catagtttta 1946461 tcttataaca aatgcgcttg agtgcaaacc agcctgcttg tattccattt caatctcata 1946521 gtttaaattt atgtttcaaa tcaggttttt acttggtctg atataccctc ttatgtcata 1946581 ataaaaaagg tcatactgct ccaaacattg agggtgaaac acagtgaaga aaaagagaaa 1946641 aggctgtttc gctgctgcgg gttttatgat gatttttgtc tttgtcatcg cctctttttt 1946701 attggtcctg ctttttttca accgggattt aatcaaaaaa cttccgatcg atacgaaaac 1946761 gattgttttg gaacgtttaa ccgattacaa acccttggtg gaagaagagc ttgaaagcca 1946821 aggactctct aattatacat cactcatatt aggcatgatg tatcaggagt caaaaggaaa 1946881 aggcaatgat cccatgcagt cctctgaatc tctggggtta aaacgcaatg agataacaga 1946941 ccctcaactc agtgttaaac aaggcatcaa gcaatttacc ctcatgtaca agaccggtaa 1947001 ggaaaaaggc gtggatttgg ataccattat tcaaagctac aacatggggg caggttacat 1947061 tgattttgta gctgaacatg gaggaacgca tactgaggaa ttggcaaaac aatactccga 1947121 gcagcaagtc aaaaaaaatc ctgatctgta tacttgcggg ggaaatgcga aaaatttccg 1947181 ctatccgtat tgctacggtg attatacgta tgcagaaaaa gtaaaagaaa aaacaaaaac 1947241 tgttgaagaa tctttgcagg ttgcaacact tgaaaccatg gaatccaagg ctcatgaata 1947301 agagtctatc aatttactga caaaagccca aaaatgaatt tgggcttttg ccatgtttac 1947361 acgtaaaaaa agccatactg agtatggctt ttaataatac ggtgaaatca tcaaatatac 1947421 aataacgcct gtaaggctta catacagcca tagaggcatt gtccatctcg caattttttt 1947481 atggcgctcc acctgcatgc tgaagcctct gatcagcgta aacagcgcaa gcggcacaat 1947541 aattgcagaa aggcagatat gtgtaattaa aataaagaaa taaatcgggc gcataatacc 1947601 ttctccgcca tagagcgtgt tttccgcaat cgagtggtac gtcacatagc aaatcaaaaa 1947661 tagtaatgtt gttgtgaacg cagccaaaat aaagcgtttg tgagctttga tatttttctg 1947721 tttaatcata atcagcgcgg ccaataagaa gataaacgta aagctattga atatcgcatt 1947781 cagcattggc aaaatgtgaa tattcgcatg gctgaactga tctaatttag gcataaaaaa 1947841 cagcactgcg attaaaccgt taatcagaac tgtcagcgta aggacaatcc ccgtgtaatt 1947901 tttcggttta ttttctgttt ggttcatttg gtgacctctc ctaatttgta ctggctatcc 1947961 aaatcgtatg caaattcaaa gaagatgtca acggtttcga ttgcttcgtc agaaattaga 1948021 cacacttcaa aggccggagg ctattagccc cggcctgtta ggtttacgcc tcttttatca 1948081 aatgttcaat gaccttatgt tcattttcat tcagcaggtt cttttgaatt ttcgaatgaa 1948141 tgggtttatt catatgctga tccaagatat cggccgtttc tttatccccg gcaataacca 1948201 ttcgttccca tcttttcgcg gcagcttttt gatcaaggct ggcagccagc cgcttataca 1948261 gtctcgattg gttctctgtt acatgttccc tcatccggtt ctcttcaaat ggtggcgctt 1948321 tgtctacagc ggaatggcta ttcttccaag actcattgat catatcatac tcataacgct 1948381 ccaccgcctc aatttttcct aaaacagttt caataatttt cacttcatgc tgctgagtta 1948441 aaataaacgc cgtacttggg tatgtctggc gcaaaccctt tagctgatcc aggacagctg 1948501 tttcttccca gtaaaatctt gtatctacag ggacttgaag cttaataggt tcccatatgc 1948561 cgctgtcgga aacaaaaaac acgagactgc ggggcatgtc ttttcccatt gcattcaagt 1948621 attgattcat tttagccctg attccatcca gacacttttc ctcctctgga tcactagctg 1948681 ccaaatactc ttttaatcgg ctgaatcctg actttagggc aatcttccat tctcccccct 1948741 gctgctctgg atctctcatg tctgtattga gatacagaga gagaatttta tccggcggtt 1948801 ccaattggac atactgtaat ttgttaatca atgaatcaat cgccattccg attcctcctt 1948861 tttcacaggt tagttttctt tttcctctct taaaaacgat caaacctgac tttccgctaa 1948921 tttctagtaa taatggaatt gttgtttaca atacgcctct cttctaatac aattggtaac 1948981 tgtgtttcta agctgttttt tgaaaggagt ttgatcttgt ttactgttaa agaaaaaaat 1949041 cgtcaagagc ttgaggaaga actaaatgat ttagaatttc aaatttatcg catgcaggag 1949101 aatatgaagg atttatctaa agatgccaaa gtgcttggta ttgatcaatc gaaacatgat 1949161 gagtggatga ttgtttcctc gattgatgat ggccaaacat gcaaaattat gctaactgat 1949221 tgtaaaacgg cataccgagg aaaaggctgt ttttcacttg tagcgtctta caaggacgat 1949281 gccattcata taggggatat aaaaggccct ccgaatcacg ggtttggctc catttgcatg 1949341 aaatatttaa aagatattgc aagagaccat aatataccga aagtcaccgg agacatcgcc 1949401 aaacgggatt ggaatcatgt agaccggctg attcactttt atgaaaaaca tcacttcaaa 1949461 gtatgtatcg atcatgatac ccaatccggc agcattaagt gggttgattt gtaaaaaagt 1949521 ctggaagaaa gagccaagat atgctgtaat ggtataaaac cattgatgga gggttctatg 1949581 tacgcctcaa aactgaaaaa gggagacgaa atccggatcg tgtctcccgc gaccagcatg 1949641 tctatattat caaatgaagc aaaaatccaa gcaaaaacgg cgttagaacg cttaggttat 1949701 cgggtaacca tcgctgaaca cgcaaatgaa tgtaacgaat ttgattcatc ctctatcgag 1949761 tcaagagtcc atgatctgca cgctgccttt tttgatccag gcgtcaaagc gattttaacg 1949821 acactcggag ggtttaattc aaatcagctg ctgcgttatc ttgattacga gaaaatcaaa 1949881 cgacatccaa aaattctgtg cggttattcc gatataaccg ctctttgcaa cgctatttat 1949941 caaaaaacgg gtcttgttac gtattcaggt ccccacttct caacatttgc aatgaaaaaa 1950001 ggactcgatt atacagagga gtattttctt tcttgctgcg cttcagacga tccgtttgaa 1950061 attcacccct caagtgagtg gagcgatgat cgctggtttt tggatcaaga aaacaggcgt 1950121 ttttatccta ataacggccc tgttgtaatc caagaaggtt atgcggaagg tactttaatt 1950181 ggcggaaact tatgcacgct taatttgctg cagggaacgg agtattttcc cgaaacagaa 1950241 catactattt tattgattga agatgattat atgtcagaca tccatatgtt tgaccgcgat 1950301 ctgcaatcac tcatccacct ccccgctttt tcacatgtaa aggcgatttt gatcggcaga 1950361 tttcagaaag catcaaacgt atcaatagat cttgtaaaag ccatgatcga aacaaaaaaa 1950421 gaattatccg gcatcccgat catcgcaaat ataaatgccg gacatacctc gccaattgcc 1950481 acgttcccta taggaggaac atgcaggatt gaagctattt cgggtacatc acgaatatgg 1950541 attgataaac attaatcagc ttgtaaattt ttttacaagc ttttttagcg caatcggcta 1950601 tgcatgccgc acgagacatg acaaatgtca tataggaggc atgatgtgtg ctactacaaa 1950661 agacttctct cattagcgta tactgaaccg agacacacaa tgagaggata cttactatga 1950721 ctgaacaaac cattgcacat aaacaaaaac agctgacaaa gcaagtcgct gcatttgctc 1950781 agcctgaaac aaaaaacagc ctgattcagc ttttaaacac gtttatccca ttcttcggcc 1950841 tatggtttct tgcttatctc agcctcgatg tctcctatct tcttacgtta gcattaacgg 1950901 tgattgccgc aggttttctg acaagaattt ttatcatctt ccatgactgc tgccatcaat 1950961 cttttttcaa acaaaaacgc tataaccaca ttctcggttt tctgacaggt gtcctgactt 1951021 tattcccgta tcttcaatgg cagcacagcc attcgattca tcatgcaact agcagcaatc 1951081 tggataaacg cggaacagga gacatctgga tgttaacagt aaacgaatat aaagctgcat 1951141 ccagacgaac aaagcttgca tacagacttt atagaaaccc gtttatcatg tttattctcg 1951201 gaccgattta tgtttttctg atcacgaacc gttttaacaa aaaaggcgca agacgcaagg 1951261 aacgtgtaaa cacatacctt acgaatctgg caattgtcgc gttggctgcc gcttgctgtc 1951321 tgatctttgg ctggcaatcg tttttactgg tgcaaggccc gatatttctg atttcaggtt 1951381 caatcggtgt ttggctgttt tatgtgcagc atacctttga agattcttat tttgaagcgg 1951441 atgaaaactg gagctacgtt caggctgctg ttgaaggcag ctcattttat aaactcccga 1951501 aactgcttca atggctaaca ggcaatattg gttaccacca cgttcatcat ttgagtccaa 1951561 aggtgcctaa ctataagctt gaagttgctc atgaacatca cgaaccatta aaaaacgtac 1951621 cgacaatcac cttaaaaaca agcctgcaat cacttgcgtt ccgtctatgg gatgaagata 1951681 acaaacagtt tgtgtcattt cgggctataa aacatatacc tgtaagcctt ccgcctgatt 1951741 caccagaaaa acagaagctg cggaagaatg cctgatgata aaggaggtct tctaatatac 1951801 tagaaggctt cctttttatt gttggagggt gcattctggc tttcacaatg ataaagttac 1951861 aagtaagatg aaaagctgaa aatgaggtaa gatcatgatt aaaaatcatt ttacatttca 1951921 aaaactaaac gggattacgc cctatatatg gacgatattt ttcatcctcc ccttctactt 1951981 tatatggaaa tcatcatcta catttgttat tattgtcggc atcattttga cgcttttatt 1952041 tttttcggta tatcgatttg cttttgtctc aaaaggctgg accatttatt tgtggggatt 1952101 tttattaatt ggcatttcaa ccgcctccat tactctgttc agttatattt attttgcttt 1952161 ctttattgct tattttattg gaaacattaa ggaacgcgtc ccttttcata ttttatatta 1952221 tgtccattta ataagcgcgg ccgtcgcagc caatttcagt ctcgtattaa aaaaggaatt 1952281 ctttctgaca caaattcctt ttgtcgttat taccctcatc agcgcaattt tattgccctt 1952341 cagtataaaa agccgcaagg agcgcgaacg acttgaagaa aagctcgagg atgcaaatga 1952401 acggattgca gaactggtaa aattagaaga acgtcagcga attgcccgcg atctccatga 1952461 tacgcttggg caaaagcttt ctcttattgg tttaaaaagc gacttagcaa gaaaattgat 1952521 atacaaagat cccgaacaag cagctcgtga actgaaaagt gttcagcaaa cagcgcgaac 1952581 ttctttaaat gaagtaagaa aaatcgtttc ctctatgaag ggcatccggc tcaaggatga 1952641 attgatcaac atcaaacaaa ttctcgaagc agctgacatt atgtttatct atgaagaaga 1952701 gaaatggccc gagaatatct cattgctgaa tgaaaacatt ttgagcatgt gcttaaagga 1952761 agctgtcaca aatgtcgtca aacacagcca ggctaaaact tgccgagttg acattcagca 1952821 gctctggaag gaagttgtga ttacagtgtc tgacgatgga acattcaaag gagaagaaaa 1952881 ttccttttca aaaggacatg gcttactcgg gatgagagaa cggcttgagt ttgcaaacgg 1952941 aagccttcac atcgataccg aaaacgggac caagcttacc atggcaattc ctaataattc 1953001 aaaataaaca taaaggatgg cttatatgat tagtatattt attgcagaag atcagcaaat 1953061 gctgctgggc gctttaggat cacttctaaa cctcgaagac gatatggaag tcgtaggcaa 1953121 aggtacaacc ggccaagatg ctgttgattt tgtcaaaaaa cgccagcctg atgtatgtat 1953181 tatggacatt gaaatgcccg gaaaaacagg gcttgaagct gctgaggagc taaaagatac 1953241 aggctgcaaa attatcatct taaccacctt cgccagaccc ggttactttc agagagctat 1953301 taaagctggc gttaaaggct atttgttaaa agacagtccg agtgaagagc tggccaacgc 1953361 catccgtagc gtcatgaacg gaaaacgcat ctatgcacct gaactgatgg aggacttata 1953421 cagcgaagct aaccctctta cagatagaga aaaagaagtg ctcgaacttg tggctgacgg 1953481 taaaaacaca aaagaaatcg ctcaggaact cagcatcaaa agcgggacgg tgcggaatta 1953541 tatctcaatg attctagaaa agcttgaagt gaaaaatcga attgaagcca ttacccggtc 1953601 aaaagaaaaa ggctggttta aataaaaaag gatcttggca tctgccagga tcctttttgt 1953661 taacctgaaa ttcccgtttg agaacctcgt cgcaaccaga attaaattga tccatatcct 1953721 cgctcctacg cccgctgaac gattgtttgg ttaacagccc aataaaagac tggattgaat 1953781 gatatccctg ttaaaatggt cggccattgc acatcagcag aatttctgat attgattata 1953841 ttgtattttc agtatgacaa agttgtgcca cttcgctccc gaagctgcca tgcccaactg 1953901 caagagccta atatcacaat aaaaaaccgt ctgaaatcaa tccgattccg taaatggtat 1953961 ctgctacatc caactgctta ttatctgcca aaaacaccag ctcgtttcgc tgatcaaaga 1954021 tagtaacaac cagctataaa tgtcatgatg ccgaatgtct ctgtaatgtg gaatcaatct 1954081 tttaacccga gagcccctga atcgcacata aagaaaaacg ggaccacttt cttttatcag 1954141 catatgatat aaacagctct aagcagaaca aaaaaagaca caagccaaaa gcttatgtct 1954201 tttatcacaa tctatattat tagtttaaga ctttaacact tacagttttg acgccccaat 1954261 tagaagcatc acttttactt ggtacaaata cgtcgatttt atttccttta atagcgccgc 1954321 cagtgtctgc tgctgttgct tccccgtagc cttcaacata gactttagaa cctagcggaa 1954381 ttacattagg atcaaccgca ataactttcg cgttcgggtt cttatttaag tcaatgcctg 1954441 tagctgtaac gccggaaatg ccgccgtcgt tagcagtgta agcagtagca gtaactgtta 1954501 gttcttttga agcttcttga ttatttgtat ttgattgaac agccttctcc tctgtgttaa 1954561 cagaagtttc tgcctcagcc tttgtttctt gtttaggttg ctgttgtaca gcttcttgtt 1954621 taggttgctc tttttgcaca gcctcttgtt ttggcgcagc ttgaggtgcg tttgtttgcg 1954681 cattctcagt agctgtgttt gctgctgttg cctgaccttt tactgaaaga gttgatccag 1954741 catagatcat gtcagagctt aagttattcc aaactttcag gttgttgact gtcgtgccga 1954801 atttttgagc aatcttagaa agcgtatctc ccgctttaat tgtatattgc ccagtcgtgg 1954861 ttgtttcttc tgaagaaatg gtcagttttt ctcctgcaat gattttatca gaagttaact 1954921 tgttccattc ttttaagtcc tttaggttca ctccattttt ctgagagatt ccccagagcg 1954981 tatcaccctt ttgcaccgta atttcttttg cagaagcgtg agctccgaat gcagttgttg 1955041 aaagtgcagc aactgccaca aaggacataa tcgtcttctt cataagtaaa tcctcccttg 1955101 ttagcttttt attggcggct aacaggtgat atcgtaacac acgtaaatgt caaatcaata 1955161 acaaaaagat atgatttaga ttacagttcc tttacatgaa ggatttctct ctgatggaaa 1955221 gacttgctga acccttgata taataggctt cgcaggtctt tttattttga ggcgaaacag 1955281 agaaaataaa atgtgttttt tatagaaaaa aagattgttt ttctgttttt ttagtctgtc 1955341 atccttgcat aagcctgtat ttcttgtaaa aaaagccggc cgtattttgc tcttttttgt 1955401 tctccgactc cttttataga caaaagttca tcatcattta cgggctgttt tcctgacatt 1955461 tcttttaacg tttggtcaga gaaaacaaca aatggcggaa caccctgctc agccgcaatt 1955521 tctttccgaa ccatgcgcaa tcgttcaaat agctcgtcat tttcagtaat cgctgccgct 1955581 tttaacgctt cttttctcgc tactgataat tctcctttca gcacattcct tcctttactg 1955641 ctgacaaaaa gagtcggaaa cgttccgtct gacatcctga tgaagtcgtc agaaataaga 1955701 aattcgataa aatcactgat ttcgccaacg gattggtgtt ttaatatccc gtatgttgaa 1955761 aggtcggaaa agccgttttc aagaactttt ttatttttgg agccggcaag cacctgggca 1955821 accatcgtct tgccaaaccg ttctttcatg cgaatgatac aagataagac catttgcgcc 1955881 tcccgcgtca cgtcatgggc cgctcttgta tcggtacagt ttccgcactg tccgcacgca 1955941 tcaggctcct tttctccgaa atacataagg ataaaacgct gcagacaatc ttccgtatga 1956001 cagtagtcga ccatttgtct cagctttttt aaatcctgct tttgtttctc ttcatgttct 1956061 gattgctcaa ttaagaagcg ctgcaccata atatcctgcg gtgaaaacag gagaacacat 1956121 tcactggcaa gaccgtcccg tccagctcgt cctgcctctt gataatagct ttccatatct 1956181 ttcgggattt gtgcatgcag aacaaatctg atatttgatt tatcaatacc cattccaaaa 1956241 gcagaggttg ccaccatcac ttgaagctca tcattaagaa atctttcctg ctgctctttt 1956301 ctcacatcat cagccaaacc tccatgatac cggcctgccc tgacctgatt tcgtttcaat 1956361 ctctcatata tccgatcagc ttcttttctg gtcgctgtat agacaattcc tgcttcatgc 1956421 ctgttgtttt gcacatattc gtctataaac cgatctttat tttctccttt tactacttta 1956481 aaggttaaat tctctcggga aaatccggta tataccgtgt tttctttttg aatatgcagc 1956541 tgtttgcaaa tatcatcatg aacctcgggt gtggctgttg ctgttaacgc catgatgaca 1956601 ggcttgtcgt gtaattcacg gaacaagatt tcaatattcc tgtagcttgg cctgaaatca 1956661 tggccccatt gagaaataca atgcgcctcg tctattgcga ccaaaggaac atctatgccc 1956721 tgcaaaatcc ggataaactc tatggacgtt agtcgctctg gtgtaatgta aaaaagctta 1956781 taagcccctt ctttgagtcc gttcagcctc tcatatattt cctgattgga ttgtgtgctg 1956841 ttaatgtagg cggcgttaat ccccgcttct tctaacgcat caacttgatc cttcatcaag 1956901 gaaatcaacg gtgaaatgac gatcgtcgtc ccttcaaaca ttaatgccgg aatctgatag 1956961 caaatcgatt tgccgcctcc cgtcggcata atgcaggccg tattttgcct cgcttccgtc 1957021 accaagcgga tcgcttcatc ttggccgctc cgaaacttct cataaccaaa ataatgagcc 1957081 agaagggatt gggctctatg taacataacg tgtaaacctc gcttttcctt gaatttctcc 1957141 catcatatca taaaaaagcg gccttcattt ctttcacaca aaaatggaat attcactata 1957201 ccaaaccttt ttagataaaa taaaaagcca tttccgaaaa ggaaatggct ttcgctacgt 1957261 cttgccgtat gcaagtaaga aagttttaaa ccaccactcc tcaaagtggg tgtttgcaga 1957321 aacgttcctg tcgtcctctg caatggaggc atgacattcc ggcttcgata taaaactccc 1957381 tattacagct taaaggttaa aacttaatta acaatacgca caaagtagct tctttaatat 1957441 agtacaccat caggcgcttt taatcaagag gtcagaacaa ttgtttagaa aaactttttc 1957501 cagtgaataa aactgttttt tctccaaaat acctgacaat tcgacaaaca aaaaatatat 1957561 tacaataaaa aaaatagcct ttattgctaa aagcgaatga ttattttctt ctatattaat 1957621 gtgtatatac aaaaagactc ctatttgtaa cgataggagt cttggcttta ttagaatttt 1957681 gcagcaagat cttttgcttc ttgtaaacct ttttcaacga tttcttgcgc ttgatcaggt 1957741 gctgcgttat gtccttcgat gacaactgtg tgcaagtctt gaacacccca gaaaccaaga 1957801 actgttttca tgaagtttaa tgacatttca agtgcagcca ttggtccttc tgagtagaca 1957861 ccgccgcgag cgttaagaag cgcaactttt ttgccgccca ttaaaccgac tggtccttct 1957921 tgtgtgtatt tgaatgtaac gcctgcgcga gacagataat caacataagt atgaagcact 1957981 gctggcactg tgaagttcca aagcgggaat gcgaaaacaa ctttgtcagc ttttacaaac 1958041 tggttcagat atttgtcagc aattgctgct tgttttttct catcttctgt catttccatt 1958101 ccttgacctg ctttaaatgt tccgttaatc atatctctgc caaggtaagg aaggttttcc 1958161 ttatgaagat ctaattcaac cacttcatca ttagggttgt tttctttata agcagctaag 1958221 aaagcttcgt aaagtttagt tgaaacgcct tcttcagctg tacggtcgct tgattttaca 1958281 aataaaactg tagacatttg tattcctccc ggtaaacttt ttatatttac ttacaaatag 1958341 tatgttactt tcttttttac gtaaagtcaa tcactttatt ttgaatatga gatttttttt 1958401 caaaaaaagc aagtacatct aatatcggtg tacttgcttg gcatttttac ttcgaatctt 1958461 gttcacgatc caagatttca tacgtctgcg agcttttttg atcaattgtt tctttgttgg 1958521 ataagtcttt tacctgttca tgaaactctc tttcataaga aggagcatct gtctccagat 1958581 catcctccac atcagcttgg gcctcaactg tcattcttgc ataaggaaca gcttcaagtc 1958641 tttcgtaagg aatctcttgg ccggtttttt cacacacgcc ataagttccg tctttcatct 1958701 tttgtaatgc acggttgacc tcctctaaca gctcccggtc aatctctttc actgtttggt 1958761 ctgtcatccg gtctgtgacg agcgtcccgt ggtctgccat atggttgtca accccattgg 1958821 aaagctcccc cacttcttcc gtcattgatt ctgtttcctt tttctcgcca gacaattctt 1958881 tttgcatatc gagcaattta tgatagagat gctgtgtttg ttcttttgtc agtgccatgt 1958941 atatcctctc ctttctatcc tgtttcccgt tttgccttct gtcaaacatg gaaacatcga 1959001 tggaaagatg agctactgcc tttttgaacg gatcgtgacc gctggcgtcg atggtgcttc 1959061 gggttttcgt tggcactttt tgtccttctc ttctggcggt atataatagg ttgcgcctat 1959121 atttaatctg ccgctcagtt catcaatggt cagctcgccg aattcaagat gatagtcaac 1959181 tttttcgaca ttcagcgttt caatatgtat ataggtttct tcagactctt gtttgctgct 1959241 ttgtttttgt ttctcaatca ctgagagtct ttcttcacat tcacgcagtt tgtcaagttc 1959301 tggtttcaag caatgcctga tcagcgaccg gaacattttt ttcatgacat cacgaccctt 1959361 tgcatactcc tctttcgtct acatatataa tgaggtatat cccatagaaa ggagaggttt 1959421 tcatgcttcc gactaacatc aatatttctc atctcaagac taactcgata ggcaccggct 1959481 catcccttac ctttggttct gcggagttaa ggaacaggtg ctctgctatc aaaagaaata 1959541 acggttttgg ggaacaaaat gcagatggta ttgttatggt cattccgatt gaatcaattg 1959601 atgaccgtga tgtgtcagat gcactcagta tgaaaatcaa tcatcaataa caatggtttt 1959661 cgcttgacct tcgtcttttt gaatagtgat gtataggatt ccgtctttaa aaatggcatt 1959721 catctttcca tgaagatgat cggaaagcgg aattttcttt tcaaaacttc cgtatttccc 1959781 ttctttttgg cgaaagtcct gttcattaaa ataggaaaag cgctgcccct tcaccactaa 1959841 ataatctccg tacgataata tgtgaacgtc ttgtttacgg tagcctggaa gataaattaa 1959901 aaactgcact tccgcaacgg tatctacaat atccatgctc ggaaatgaag catctccttt 1959961 ccctcgctga tcttgctgcg caaacggaaa cggagattgg ccatttgtca taaaaggggt 1960021 tttttggtct tcatcaaata cctgtttcca aaagtcaccg ccgtacatct gctgtgcgaa 1960081 ttccatccac tgcttcatct tttcgaaatc catttgaagc cccctgtctt aacatacttt 1960141 ataaccgcca gcatacaact atagaaagga ggtttgcctg tggttcaacc aactccgtat 1960201 atcaatatta atattttcat gctgaaaatt aattcctttg aaaatgcttc agcggttaac 1960261 gtaggacaaa atttattggc agaatggcaa aattcagata aaaaaaatca aggctacgga 1960321 cagaattttg gagatgcgag cggatttatg ggcacgagaa gccatgtgga tgacagagac 1960381 caaattgatt ctccggcctc ttttgaaagt gaagcggtta actcctcaat caaaaggaag 1960441 tgatgagatg ttcttttcac cctccgtcgt aaatgtcggc ggatttaaaa tcaatacgat 1960501 ggatcgaggt tcctctttaa cactcggtcc gtatcagcag gtcgattact ttttatcagc 1960561 taaaataaat caagggtttg gagaagaaaa tggcgacttt actcctcttg tcgtgccgat 1960621 ttcaaatgta ttagatgcag atcttgttga ttcgaactca gcgaaaaaca gtgtggtgta 1960681 ataagaacag ggcgcacatg ccctgttctt gtttttatat ataaaaaaag cctaaccatt 1960741 ttttgaacgg ctggctcatc aaatattcag ctgcacaaat gctttgtcag caccgcctga 1960801 acctcgctta aatcggtgtc tttcgcaaat tctaattcga aagttttgct tcttgtcatc 1960861 aataaaagcc cagtgtccgg atcaaacatt cccgcttctt ggatggcaaa gctttcaatt 1960921 gttttatatg gaagaaatac acgaaccttc tttttagaaa acattttatt gtcaaagaaa 1960981 atgatccgct tatttgtaaa gcaaatttgg tccactcgga gcttataaat cgattcaatt 1961041 ctttcccctt caacgagcaa agcctcaagc ttctttgcgt ccgttgatct gctaacagaa 1961101 aaaataccca atgaagaacc cctctttctg catttatcta tttgttttat cattcactac 1961161 ataaaaataa gtcctttatc cctatataag aatacgacat agaagacatt taaaccatta 1961221 cgaacagatt acatttttca aatttttgat ttgttttttg gcttttaagc tgttgtcatc 1961281 aagtaatacg cacatataga gaaaaaagtt tcaatattca gcaatgtttt tataaaaaag 1961341 tggtttttaa tgattttttt aattttgttt tatatttcct gttttaacca caaaaaaacc 1961401 gcagctgagc tgcggtttta tgtatcgact gcttttaaca aaatctgttt gatgcttcaa 1961461 ggaagcatta catctcttcg aagtattctt tataatagcc gccgacttta ttcgtattgt 1961521 cgaccacaaa gagaaactcc tctgtttcat tttttacttc atattctttt cccggcgtta 1961581 aaacgcggtt tacgatatat ttttttgcgt ttgtctgcac acactttact tttttaatgg 1961641 tttctttttc aagccaattt ttatgaatca tgatgaaatc tccttttctt atctataagc 1961701 ttattgtagc ttttttcttt tgtaaattgc aatatcggtt attcattgat tttgccttga 1961761 tttctattat agaatgtttg tatacgctta cgtttgaagc aactatcaca gcttatttct 1961821 gctattcaat ccaggaatca atgtgctatc accaagaatc tcagaacaga ccataaaaaa 1961881 tgactggagg tttgttacgg atgagttctt taacgatgca agtgacgaaa aggctggaga 1961941 catttttaca gggaacaaag aagctttata ttgacggaaa gtttgttccg agtgcctcag 1962001 gggcaacctt tgacactcca aacccggcga ccggcgaaac cttgatgacg ctgtatgaag 1962061 cccaggctgc ggatgtggac aaagctgtta aagctgcccg gaaagccttt gaccaaggtg 1962121 aatggagaac aatgtctcca gcttcgagaa gcagactgat gtataagctg gcagacttaa 1962181 tggaagagca taaaactgag cttgctcagc ttgaaacact tgataatggg aaaccgatca 1962241 atgaaacgac taatggagat attccgctgg ctattgagca tatgcgctat tacgccggct 1962301 ggtgtacaaa aataacagga cagacgattc cggtttccgg cgcttatttt aattatacgc 1962361 gtcatgagcc tgtcggtgtc gtcggccaga tcattccatg gaatttcccg ctcctgatgg 1962421 cgatgtggaa aatgggcgcg gcacttgcaa caggctgtac aatcgtcctc aaaccggctg 1962481 aacaaacacc gctttcagct ctttatttgg cagaattaat tgaccaagcc ggtttccctg 1962541 ccggtgtaat caacatcatc ccaggattcg gtgaagatgc gggagaagcg ctgacgaacc 1962601 acgaagcggt tgataaaatt gcctttaccg gttccactga aatcggaaag aaaatcatgt 1962661 ccaccgcagc gaaaagcatt aagcgtgtga cattggagct gggcggaaaa tcgcctaata 1962721 ttcttctgcc ggatgcgaat ttaaaaaaag ccatcccggg cgctttaaac ggtgtgatgt 1962781 ttaaccaggg ccaagtctgc tgtgcgggct cacgtgtctt cattcataaa gaccaatatg 1962841 atgaagttgt tgatgaaatg gcatcctatg ctgagtcact ccgccaagga gcgggacttc 1962901 ataaagatac tcaaatcggg cctctcgtaa gcaaggaaca gcatgagcgc gttctttcct 1962961 atattcaaaa aggaaaagat gaaggagcaa aagcagtgac cggcggaagc tgtccttttg 1963021 aagcaggata ttttgtcgca ccgactgtgt ttgcgaatgt tgaagacgaa atgaccatcg 1963081 caaaagaaga aattttcgga cccgtgctga ctgcaattcc gtacgaaaca gtcgatgaag 1963141 ttattgaacg ggcaaaccat tcagaatatg ggcttgcagc cggactatgg acagagaacg 1963201 tcaagcaggc tcactatatc gcggaccgac ttcaagccgg aaccgtttgg gtcaactgct 1963261 ataatgtgtt tgacgcggcg tctccatttg gcggttataa acagtcagga ctcggacgag 1963321 aaatgggatc atatgccttg gataattaca cagaagtcaa aagtgtatgg gtaaaccttg 1963381 aagactaaca tgtatgttta aaaaactgct gcctgccagc agtttttttc tttctgtaat 1963441 ggcagtaaaa gacgctgaat atatatgctt ctgaaggagt tgagcgtgat gggcacactt 1963501 caggagaaag tgaggcgttt tcaaaagaaa accattaccg agttaagaga caggcaaaat 1963561 gctgatggtt catggacatt ttgctttgaa ggaccaatca tgacaaattc cttttttatt 1963621 ttgctcctta cctcactaga tgaaggcgaa aatgaaaaag aactgatatc atcccttgca 1963681 gccggcattc atgcaaaaca gcagccagac ggcacattta tcaactatcc cgatgaaacg 1963741 cgcggaaatc taacggctac cgtccaagga tatgtcggga tgctggcttc aggatgtttt 1963801 cacagaactg agccgcacat gaagaaagct gaacaattta tcatctcaca tggcggtttg 1963861 agacatgttc attttatgac aaaatggatg cttgccgcga acgggcttta tccttggcct 1963921 gctttgtatt taccattatc actcatggcg ctccccccaa cattgccgat tcatttctat 1963981 cagttcagct catatgcccg tattcatttt gctcctatgg ctgtaacact caatcagcga 1964041 tttgtcctta ttaaccgcaa tatttcatct cttcaccatc tcgatccgca catgacaaaa 1964101 aatcctttca cttggcttcg gtctgatgct ttcgaagaaa gagatctcac gtctattttg 1964161 ttacattgga aacgcgtttt tcatgcacca tttgcttttc agcagctggg cctacagaca 1964221 gctaaaacgt atatgctgga ccggattgaa aaagatggaa cattatacag ctatgcgagc 1964281 gcaaccatat atatggttta cagccttctg tcacttggtg tgtcacgcta ttctcctatt 1964341 atcaggaggg cgattaccgg cattaaatca ctggtgacta aatgcaacgg gattccttat 1964401 ctggaaaact ctacttcaac tgtttgggat acagctttaa taagctatgc ccttcaaaaa 1964461 aatggtgtga ccgaaacgga tggctctgtt acaaaagcag ccgacttttt gctagaacgc 1964521 cagcatacca aaatagcaga ttggtctgtc aaaaatccaa attcagttcc tggcggctgg 1964581 gggttttcaa acattaatac aaataaccct gactgtgacg acactacagc cgttttaaag 1964641 gcgattcccc gcaatcattc tcctgcagca tgggagcggg gggtatcttg gcttttatcg 1964701 atgcaaaaca atgacggcgg attttctgct ttcgaaaaaa atgtgaacca tccactgatc 1964761 cgccttctgc cgcttgaatc cgccgaggac gctgcagttg acccttcaac cgccgacctc 1964821 accggacgtg tactgcactt tttaggcgag aaagttggct tcacagaaaa acatcaacat 1964881 attcaacgcg cagtgaagtg gcttttcgaa catcaggaac aaaatgggtc ttggtacggc 1964941 agatggggtg tttgctacat ttacggcact tgggctgctc ttactggtat gcatgcatgc 1965001 ggggttgacc gaaagcatcc cggtatacaa aaggctctgc gttggctcaa atccatacaa 1965061 aatgatgacg gaagctgggg agaatcctgc aaaagcgccg aaatcaaaac atatgtaccg 1965121 cttcatagag gaaccattgt acaaacggcc tgggctttag acgctttgct cacatatgaa 1965181 aattccgaac atccgtctgt tgtgaaaggc atgcaatacc ttaccgacag cagttcgcat 1965241 agcgccgata gcctcgcgta tccagcaggg atcggattgc cgaagcaatt ttatattcgc 1965301 tatcacagtt atccatatgt attctctttg ctggctgtcg ggaagtattt agattctatt 1965361 gaaaaggaga cagcaaatga aacgtgaatc ttatcaagcg gagatgttca attggtgtga 1965421 agccctgaaa gatcagattc aaaagcgagg tcagcttgac cagtttgaag atcaaatcga 1965481 caagatgatt gaggctctgg aagatgacca aacaacagaa gaagattggt ataaacaggc 1965541 cgctgccctt tatcgggata ttacagaatc agatgataca agtgaaagac gcgcttatgt 1965601 ccctataggg aaacacgtgc tgccaaagct tccttacaaa tactccgcct tagaacctta 1965661 tatatcacgc gatattatga tccttcatca tacaaaacat catcaaagct atgtcgatgg 1965721 cctgaacaaa gcagaatcag agcttaaaaa agcgagagcg acaaagaatt atgacttaat 1965781 cactcattgg gaaagagagc ttgcgttcca tggagcaggc cattatttgc atagtatttt 1965841 ttggttttct atgcatccaa acggaaaacg gcgtcctaca ggggcattgt tccaaatgat 1965901 agacctttca tttggaagct attccgcttt taaagaacat tttacccagg cctctaaaaa 1965961 agtggaaggc gtcggctggg ccattctggt ctgggcacct cgatcaggac ggctggagat 1966021 tttaacggca gaaaaacacc agctctttag ccaatgggat gtgatccccc ttttaccgct 1966081 tgacgtatgg gagcatgcct actatttgca atacaaaaat gaccgggcca gctatgtcga 1966141 tcactggtgg aatgtcgtgg attggcgcga ggctgaaaaa cgttttgagc aggcaaaaga 1966201 agtcgtttgg aagctctatt aaaaaaagcc ccctttcctc gggggcttcg tgtgttaaaa 1966261 aatacctatc acatgcaaaa acacgatgat gatggcaaca ggagatagat atcgaatgag 1966321 cagcagccaa accgcaaacc actttcgttt gagattggaa ccgcttttca gctcgtcaaa 1966381 caaatcctgt ttcggtattt ttagcggaac aaaaatcgaa atcagtaacg cacctaacgg 1966441 cattaaaata ttgctcacaa gatagtcagc cgcatcaaaa atagacagat gaaatatagt 1966501 gacgtcactt aagacaccgt atgataatgc agacggcaca ccgacaataa aaatagcaat 1966561 accgcctaac caagcgaatc gttttctctt attgatatcg cctttcgaca gtactgcgac 1966621 caaaatttcc agcattgaaa aagcagatgt caatgcagca aataaaaata gaagtaaaaa 1966681 tgctaataaa aagataattc cgaacggcat ttgattaaac acagtcggca gaacgttaaa 1966741 taacagaacc gggccttggt ctggcttgag gccgaatgaa aatacagctg gaaaaatcgc 1966801 aattccggcc attacagcaa caagcatgtt cataacagtt acagatacag cggactgtac 1966861 cagattttcc tgtttctcta aataagcgct atacgttacc atgacagata caccgacact 1966921 taataagaaa aaggattgtc ccattgcata taaaatggta ttggcatcaa ttgcagttaa 1966981 atcaggcatg aggaaaaatt tgattccttc catcgcgcca tcaagtgtaa ccgaacgcac 1967041 cattaaaatg atgaataata gaaaaagcgc cggcattaat acttggcttg ctttttcaat 1967101 tccgctgctt accccttttg caacaactaa aattgttacc accataaaga gcagctggcc 1967161 tcctacagcc aaataaggat ttgaaatggt acttgcaaat atcgtatcaa aaccagatgt 1967221 ttgcgataaa ccgccagtga agccttttat aatataaatt aaaatccatc cgcctacgac 1967281 actgtagaaa gatagaagaa taaagcacgt caccatgcct aaataaccga tccaatgcca 1967341 cttcgttcct ggagcaagtg ttttatagga ctgaacggca tctttctgtg ttcttctgcc 1967401 tatgatgaat tcacctaaca ataaaggcag tccgattaaa accgtaaata aaataaaaat 1967461 aagtaaaaat gcgcctcctc cgctggttcc ggcaacatat gggaatttcc atatcgcacc 1967521 aagcccgata gctgatcctg ccgcggctaa aataaagccg agcttcgaag accattgatt 1967581 tgcttccttc accgtatcac tcctatttga tctaaccatt ataaaggttc attgtaagaa 1967641 tatcttccta tatagtcaag aacattttaa ttagtttaca tcatatatct atagacatct 1967701 gccaaaaact aatattgaat tattcagaaa attatttata ataagagaat gttatgaaat 1967761 ttgtaagaat ttctgctgaa gttcttgata agtgtgttag gagtgttttt atggacatca 1967821 ttagaaaaat aagccatttt gcaggacaaa cctttggcat atgggtcatt gtttttgcag 1967881 tgctgggatt ttctttccca tctttattta cgtggatcag ttcttatatt acgatttttc 1967941 tcggcattat catgtttggg atgggcctta cactgcaagc cgatgatttc aaagagctgg 1968001 tcagaaagcc ttggcaagtt attattggag taatagctca gtatacgatc atgccgctcg 1968061 ttgctttcgg cctcgcattt gggcttcatc ttccagctga aatcgcagtt ggtgttattc 1968121 ttgtcggctg ctgtcccggg ggaactgcat ctaatgttat gacattctta gcaaaaggaa 1968181 atactgccct ttctgttgcg gttacgacaa tttctacctt attggcacct gttgtaacac 1968241 cgttgttgat tatgctgttt gccaaagaat ggcttcctgt ctcgccgggg tctttgttta 1968301 tctcaatctt acaggcggtt ttatttccga tcattgcagg tctgattgtc aaaatgtttt 1968361 tcagaaaaca agtggcaaaa gccgtacatg cccttccgct tgtttctgtc attggcatcg 1968421 ttgcgattgt ctcagctgtc gtcagcggca atcgggaaaa tctgcttcaa tcggggttgc 1968481 tcattttttc agttgttatc ctgcataacg gtatcggtta tttactgggg tttctttgtg 1968541 caaagctttt aaaaatggat tacccgtctc aaaaagcgat tgcaatcgaa gtcggcatgc 1968601 aaaactccgg gcttggggct gcacttgcca cggctcattt ctcaccgcta tctgccgtac 1968661 caagcgcaat attcagtgtg tggcataacc tttcaggttc tatgcttgca acatattggt 1968721 caaaaaaagt gaaaaagaag caagctggat ccaaaagcag caatctatca ctttaaatat 1968781 gcatcaaaaa gggtacatca ctttatcgtg atgtaccctt ttttattatc cttctaataa 1968841 aagctgttca ggatcttcca gtaaattttt gattgtcacg aggaaaccaa ccgcttcttt 1968901 accgtctaca attcggtgat cataagataa agcgatatac atcatcggac ggttttcgaa 1968961 acgctcttca tcaatggcta cagggcgcag ctgaatctta tgcatgccca gtataccgac 1969021 ttgcgggctg tttaaaattg gagttgacat caatgaaccg aaagtccctc cgtttgtaat 1969081 cgtgaaggag cctccctgaa gctcgctaag ggttaattta ttgtttcttg cttttttcgc 1969141 aagctcgccg atctcttttt cgattcctgc aaatgtcagg cgatccgcat cccgtacaac 1969201 cggaacgaca agaccttcat cagcagcaac agcgattccg atatcgtaga attttttaac 1969261 gatcaactca tcgccttgaa tttctgcatt caacagcgga tattttttca atgcagccac 1969321 gaccgctttc gtgaagaaag acataaagcc gagcttcact tcattttgct caaaaaattg 1969381 atctttgcgg cgttttctga gattcatgac agccgtcatg tccacttcat taaatgtagt 1969441 cagcatcgct gatgtttgct gtacctctac aaggcgtttt gcaatcgttt gtctgcggcg 1969501 tgacattttt tgcacttcaa caggtttgtc aaagctttgc tgtgcttttt gagcctgagg 1969561 ctgctgcttt tgctgaggag ccggttttga tgccggtttt tcgtacgctt cgacatcctg 1969621 cttgcgcact cttccaagcg gatctccagt tggaacttga gacaggtcaa ttcctttttc 1969681 tctcgcaagc ttacgggccg acggagaagc gatcgttctt gattttgctt cagattgtgc 1969741 ttcctcgctc acctcttgtg cagctggttc agcctgtttc tcttctttta cgctttcctt 1969801 gctttctgtt ttctctgtag gagcaggggc agaactttca cccgcgcctt ctgaaatcgt 1969861 accgataatt tctccgacct ggacggtatc acccgaatct ttcaatacct cttgaagtac 1969921 acccgattct tctgctgtca attcaacatt cactttatcc gtttctagtt caagcagata 1969981 ttcaccctgt tctacatagt caccaggctg ctttaaccat tgggctattg ttccttctga 1970041 gattgattct gctaattcag gtaccttaat ttccgccatt ttttcatttc ccccttagtt 1970101 tttgcgagtc aagctatcag atacaatacg ttcctgttct tttttatgaa ctgtcggatc 1970161 tccctctgca gggctggatc gtcttcttcg tccaatatat tgaacgctta ctccctctgg 1970221 tgcaatctct gtcaaatacg ggctgatata accccaagcc cccatgttct gcggctcttc 1970281 ctgcacccaa acgatttctt tcaggttcgg aagttttgca aataattctt tgactccttt 1970341 tgccgggaat ggatacagct gttcgattct cgcaatgtga agccactctt taccgtcttc 1970401 taacttatta aaatgatcgc taatgtctat agacacttta ccgctggata atacaagtct 1970461 ggttactttt tcatagtcat gagaaagtcc cgactgttca taaacaggct ggaagcggct 1970521 ttcgctgagc tcctgcactt ccgacaccgt atttgggttg cgaagaaggc tcttcggcgt 1970581 cataatgacg agcggtctga tttcttcacg aagcagcatt ttagcctgtc ttcttaaaat 1970641 atggaaatac tgtgccgcgc ttgtcaggtt ggcaaccgtc cagttgtttt ccgctgcaag 1970701 ctgcaggaat cgctcaattc ttccgcttga gtgctcaggc ccctgtccct cgtaaccgtg 1970761 cgggagcagc atgactaatc cggatttttg gccccatttc gcgcgtccgg cagaaataaa 1970821 ttggtcaaaa tacacttgag cagcgttggc aaaatctccg tactgtgctt cccacaaaac 1970881 aagcgtttcc ggtgaatgca cgttatagcc gtattcaaaa ccgagaaccg atccttcaga 1970941 cagcgggctg ttatgaacag caaatgatgt gctgcagtca gataagtgat gaagcggcac 1971001 aaattctttg cccgtctcac tgtcatgaag cacaaggttt ctttgggcga acgttccgcg 1971061 ctcggaatcc tgtcctgtta aacgaatcgg tgttccgtct ttcaaaattg aagcaaacgc 1971121 gagtgattct gccaaagacc attccacttt tctgtcatca tcgaacgcct tggcgcgtct 1971181 ttctaaaatg cgctttagct tgccgaaaac attaaatgac tccggccagt tgatcaattc 1971241 gccattcagc ttgcggagca catcaaaatc aatcgaagtg tccacatctg ggaaaccgtt 1971301 tgatacaggc tctggaagtt caatttcaca agcagtgtgt tcctttttag acggaacttt 1971361 ctgatatgca tcctcaatgc gcttcgttac cgatttttcg atgttttgaa cgacttcctc 1971421 ggtaaccacg ccttctttta ccagcttttc agcgaaaatt tgtttgacgg tcggatgctt 1971481 tctgacagca tcatacagca ttggctgagt ggttgacggt tcatccattt cgttgtgtcc 1971541 atagcgtctg tacccgatca aatcaatcag aaaatccttg ttgaatgttt ttcggtattc 1971601 gaccgcaaac ttaacagctg aaagacaagc ttcaggatcg tccgcattca cgtgaacaat 1971661 cggaatttca taacccttgg ccaggtcgct ggcatatttt gtcgatctgg attcagcgct 1971721 ttctgttgtg aatccgatca tgttattggc gataatatga atcgcaccgc ctacttgata 1971781 cccttttaaa gagcttaaat tcaatgtttc agctacaatt ccttccccag ggaatgcagc 1971841 gtctccatgg attaaaatgg ccagcgattt tgtttcatct tgtaccgggt atccgctttg 1971901 tgttcgcgtt tcctgtgccg ctcttgtgct gccttcaaca atcggattga taaattccaa 1971961 gtggctcggg ttgttcgcta acgtaatgcg cgctgatttt gtttcagcgt cttgaagctc 1972021 ccgattcgcc cccaaatggt atttgacatc ccccgtccat ccgtagctga ttccaatgga 1972081 tccctcagac ggtacaagat ctttgttcgg cgcatgctgg aattcagaga agatgatttc 1972141 atacggtttg ccgagcacat gtgccaagac attcaggcgt cccctgtgcg ccatcccgat 1972201 gttgacactt gtcgtgcctg atttgacaga ttgtgcaata atgtcatcaa gcactggaac 1972261 aagagcgtcc agaccctcaa tggaaaagcg cttctgcccg acgaatgtgc ggtgcaaaaa 1972321 ctgctcaaag ccctctactt ctgtcaatct ttccagcaca gctgacagct tttcagctga 1972381 gttcttctgg aacagctcgc cagattcaat ctttcttgtc agccactcgc gctctttgaa 1972441 gtcatgcaca tggtcaaatt caaaagagat ggttctttta tacgtatttc gtaaatactg 1972501 aatggcttct aaaccgttcg aaatgttttt aggagcgtct ttgcagatga cagacgcagg 1972561 tattgctttt atttcctctt ctgttagccc gtaatcggat aatggaaaaa gttcgctctt 1972621 tttctcatcc tttctgagcg gattgacgga agcgttcaaa tggccatagg ttcggatatc 1972681 ttctgcaagt ctgactgcgg atgcgatctt ttgaatcaga tcggctgtaa cacgtccctt 1972741 ttcttttgtt cccgaggcct cttttatatc gcttggcgga gcaccgagct cgtcgaacat 1972801 ttccttcaaa tccgggtcaa tgctgttcgg atcctgggta tactgatcgt aaagctccag 1972861 cgcatagccg aggttcggac cgtaaaaatc ttcccaattc attcgttgtt tcatactatt 1972921 ttgaaacatt tgaatattac ccccaactta aataatcaag tgattgattc actatcttga 1972981 aataactttc gaacgctgtg tccaaaatta tgtaataaaa acgcttccaa cgatatttta 1973041 ccactgtttg caatttgatt ctaccttgat tgttcacaaa atagtaaaaa acctttataa 1973101 aaaacaaaaa atttaatcat tcgaaaaaac aaacgccaaa aagcatagga ttaagggcta 1973161 tcctatgctt ttatgaagca gttttttcag cagcggatac aaaacatccg gtagctgatc 1973221 aacatccggg acaaatatac tgaattttcc gtacatatcc tggatcgtct tcatttgcga 1973281 ttcttctatt tctgagttgg agagaaaaac atttatcact tctattcctc tttttcgggc 1973341 ttcgataacc gcctcacttg tatcaacgat cccattttgt tcgtagccaa atgcggccgg 1973401 ctctccatct gagaaaacaa ttaagaactt ttgcgcctcg ctgcgatgca gcattttttt 1973461 cgtcatctgc ctaattgcgt acccgtcacg gttatcttct tctggctcaa gctgcataat 1973521 ggccggtcca gaatcttgtc ttaatgatga ttggaaggga ataaccgtat tgaaatagtt 1973581 tggctggctt ttttcggttg catcatttgt gtcctcccaa aaaccgacaa tctgatgcgg 1973641 aaccgctacc gatttcaacg cttcgtgaaa cagcacgatt cctcgttttg tttcgtccat 1973701 tttgtcgaac atgctggcgg aacaatcgac cagcaatgta aaaactgcgt cgatttctga 1973761 agatggttct tgctttttgt agaacaggcg cggatttcgc tcagtgaagt aacgaagaag 1973821 cttattgttc agtctcccgg catgaaggtc tgttctcggc aatgtttttt tatgctccag 1973881 cgttttttga atcatttgtt tcaaacgctt ttgatacgat tcaatcgttt ttgcctgctg 1973941 tttataagaa agctcttctt cactggttgc cggctgcggt tctttataaa ttggaaatgc 1974001 atatttattt tctttgccgt cagccatacc cgctccgttc ggctggtctt tttgggactc 1974061 cagcgcttcc agcttggaat agtctttccg tttcgtttgt ctggctgatc cttgaacaga 1974121 gccaagggcc tgatctccat cgtcgccttc ccttgaagca tcttttccta aatctgattt 1974181 tgcgccgtgt tcaatatcaa attgaaggaa gcttttagac ggtgcttctg tttcccggtg 1974241 ccatgtcggc atttcttctt catggatatc ctcatcaccg tctgattgtt ttggaagcgt 1974301 gatgtcatca ctcagcttcg gcgctttttt ctcttcttca aataacggct gttctgcagc 1974361 ttttgcgtaa tcaagctcag gcaaaaagaa gtaggtgttc aacatgtctt tatcgagtac 1974421 ctcttcaagt ccgtccatga ggtcctcaac aattttcaga acctgccgtg tcgaatctgc 1974481 ttcatacaca cgcaagagct gctgctcaat aaacgggcgc atcagatcga tatcttcacg 1974541 catggatgga agggtctcga gcggcgattc cgctgtgagc ttgaaataga tcgcgcaaaa 1974601 gagcgcatcg gtaaaaatgc ttcgttccaa atttaaggtc agctgggttg agaaatgttt 1974661 tctgtacatg tcttttcgct tcgcaaatac atgtttcgta cccgggcgct cacgtttgat 1974721 gcattcttcg atcctaatgt cttcaagcag cataaagagc tgcttggcaa aacttttaaa 1974781 cgtaagatgg cgatggatat cattcaaaaa gttcgcaaac tcatgcagcg agctatatct 1974841 tgttccgact gaacgcaggt agacgtcgct tttcagaccc gcttccatgt cctcagctgc 1974901 cctgtctttc caaaagtggc tcatatagat tttcttttca aatggattgt aataggactg 1974961 aacgccatac tccacttcta ccgcttcact cttggtgagt gttttggcca aatcagtcag 1975021 catcataaat aaaaatgaat caatcgtgct gtcgttaaat ttgataaatt tcatcgcagc 1975081 cccctcattc aaacagagtt tctgcaatat ttcggacagc cgctttttcc cgatcatcat 1975141 caagcttttc tacaattccc cgctcaatgg cacgacgcgg cggaatataa gcagctaaat 1975201 cacatgtatc gattaaagct ctgatggatg ccgcttcttc agacacctgt ccgttattgg 1975261 cctgaacgat caagtcagag gaaagcgtga taaatctgtc aatcaatttc tcgtctttca 1975321 aggctgactg agacatgagc acttgtttca gcagctcgcc tttaatataa ggcacatcaa 1975381 tgatgacaaa acggtttttc aacgcttcat tcagaggaac agttccgaca tagccttcat 1975441 tgatggctgc aatgactccg aaaccgcttt tagcccgtat gacctcgcct gtaaacggat 1975501 ttgtcatcat ttttctgtaa tctaatacac cgtttagaat aggcagtgtt tccggcttcg 1975561 ccatattgat ttcatctata taaagaaaat ggccttcctt cattgccttt gtaacaggtc 1975621 ctgaaacaaa ctcgattgtt gcctggccag attgattttc aatcgtttta taaccgacca 1975681 atgcctcagc gtccaagtcg actgaacagt tgacgctgtg catcggttta tgaaaatagc 1975741 tggacaatgt ttctgccagc tttgtttttc ctgaacctgt aggccctttc agcaggacat 1975801 ttttccccat ggctaatgca ataatggcgt caaataaaat ggcttcatcc tccgcctcat 1975861 agcctgatgt tcctataagc gattgaaact ctggggaaat aggctgctct ttatatgata 1975921 aaagcttttg ttgtatatct tccggcaatg ttaagtgctg tagttgagtt gtcatagaca 1975981 gattcccttt cctattcata ttccattaac gagtatacta aaaaagcccc tgtatgctca 1976041 atacaaaagg gcctggatga tattactgct tctcgttatt tcccaaaagg gctccgcaga 1976101 caatacgcgc accggaattg ccgcttgggt ttgtcagata atcgtccgct tgttcatgaa 1976161 taataaatgc acttccgtcc tcgtcgagaa tatttagttt acttcctttt ttcagtgaag 1976221 tgtcaggcgc attcattatg acatctacct ttccatcagc accgacttca aggttcggca 1976281 gatctccggc atgatgcccc atcggattat taaagccgtg ttctttgttc agtggattaa 1976341 agggaccgcc cgctgattca aaatccggcc tgacacaaga acctttctca taaatatgaa 1976401 aaccgagaga agcacctgga cgcaggctgt ttgcggaaat atgaatatcg aggccttcat 1976461 catctgattc tttgatctct ataaaaccga ctgctttccc ttcacgattg accagctgga 1976521 catgatgacc aaacgctgac gtttcaacca cttttttttc cggcacccgg ttaggagggt 1976581 ctggaggttt tttttgtccg catccggcaa ctcccagtgc cgtcagcatc atcaacagca 1976641 agagacggtg catactgtct cccccttgtt ttttctaaca gtgtggtcaa tcattgtctg 1976701 gtataaacaa aaaagcctat aaaaggcttt ttgtcatact catttttaaa aataacttct 1976761 tgcgcccaag taccgctgtt tccaatacga attgctgaga ttggaaatgt cgacgcccga 1976821 tgagcttgca tgaataaaat caccgccgcc tagataaatc cccatgtgag acgggccgga 1976881 tttatatgtg gtaaagaaga caaagtctcc tactgacggc tggctgactt tctgcatgac 1976941 attccaatac cctgccgtac tcaatcttga tatagatgat acattattaa tgaggtaata 1977001 aatgaagccg ctgcaatcaa aaccggcagg cgtgtttccg ccccatcggt aaggcactcc 1977061 gacatatttt ttcgcttccg ttatcattct gtcaatcttc gaacctattt gaatgtttga 1977121 ccctgagtta tcttttggct ttgttggctt tgtcggattt gaaggattag attttgatgc 1977181 tcccgaaata gtcagaacct gcccgatttg caacacatcc gatgataaat tgtttttatc 1977241 acggatgctt tggacagtga ctccgagccg atttgcaatt ttccacagcg aatcgcctgc 1977301 ttttaccttg tacgtcgttg tttttgaggg attggagttt gacggctttt tggaaccgct 1977361 gtttccgttc ttaggtgaac tgcttccttt tattttgagc acctgtttag gataaagtgt 1977421 atctgatgtt aagccattta aggtttttaa ttcggctaca gtcatattta agctgtttgc 1977481 gattttccac agtgagtcac caagcttgac cgtatatgta ctttttgaag aacctgaaga 1977541 attggaaccg ctgtttttct ttgatccatt tgatccgctt gaactgcttg tccctttgat 1977601 cttaagcttt tgccccggac gaatcaggtc actgctcagg ctgtttaagc ttttaagctc 1977661 agaaacactc attttatgat ttttagcaat catccatagg gaatcaccat atgcaactgt 1977721 gtatgttgat gttttgcttg aattagatgg ggatgtcgtg ctttttttgc tgctttcagg 1977781 aaccttaaga ctttgtccga cataaagcac cgttgatttc aatttgtttt cggatttcag 1977841 agctgatatt gtcgtatcat actggcggga aagtttccaa agagagtcac cgctttttac 1977901 ttttatcgtt tttgcttccg cgggtgctgc ggccatcgac gacccaacaa ctgcagaaac 1977961 agccaagccg gctacaatct tctttttcat tcattcaacc tcctaaactg tttttttgca 1978021 aaaacagcta gtattttgtt tccaaaaatg gcacacaact gttttatcgt caatttttca 1978081 gcaagttaaa cccttttcaa acatttggcg cagcattttc agcatcgttc gacctttaaa 1978141 ccttcaaata aacatctaac attttacata agcacgatat gtttttcgaa agtctaagga 1978201 actatttaag cgagggtaaa aatgatggtt ttctattgat gaacgaagca gtttctcctc 1978261 ctttcttgtc tatttttcta atcaattctc tatcggcgtg tcaaatccct tcctctgcat 1978321 tcttatgaaa tggcaaaaag cctgttcttt cgataagaac aggcttttac actatgcatt 1978381 tgctgattga gttttttgtt ttacagcttc aagaatgctg tcggctgctt ttttagagcc 1978441 gcctgccgct ttcagtgatt gtccaatttc ttttgccttt tcagcatacg aacgattatt 1978501 cattacttct tgtatcgtct ctttcagtag gctttcagac aattcttcct ttttaattac 1978561 ttttcctgcg ccgacttttt ctacctgatc tgcgacaaca aattggtcgc ctcccatcgg 1978621 aatgacaacg agcggggttt caaaatacaa accttcactt gtgctgttca ttccgccgtg 1978681 ggtcacaaat aagctggctc ttttcaagat ctcaagctga gggacatacg ggcgtacaat 1978741 gaaattctcc ggaatgtcgt ttaactcact tgttttaata tgcttgccga tggaaagcac 1978801 aactttaccg tcaaagtcct tacacacttc aaggcattga ttaaaaaact gcttttgatt 1978861 attaaaaatg gttcccattg aaataaacag cacgttttca ttgtcaatct gatcaaatgg 1978921 gaaatcattg tttccggctc tttctgtaat ggaaggaccg acaaatacat atcgctcgcc 1978981 aaattgctca gccagtggct gaaatcccct tgatgtaaag acgattgtca agtcaccatc 1979041 agctaaaaaa acatcaaatg gcttcttgat ctctgcttga aaatcagcat ttaacgtttc 1979101 tgcaagctgc tggtatgatt cataatgagg cgaatcttca agtgatcctt tcatgtacgc 1979161 tcccatcatt tccttcgcaa attcctcatt catcgcaaag gttgtacaca atgaaaatct 1979221 tggcagcttc agcatgttgg caatgacttt acccgcgaga agatggtgat catatatgac 1979281 ataatcatac gattcatgtt tgacttcctc ataaatatga gtcgcgatat ccttacaggc 1979341 tttcaaaaaa gcgcagagca tttctgtgaa atctctttct tcatcgccgg ttgcgttttt 1979401 cccgaagtaa tctcctctga aatcatgata ctcacgaaac tctatatcaa gagctgtgat 1979461 tttttcttta tattccttca ctgcgtagta cgtaatgttt tctccccggg atttcagctc 1979521 cttcatcaca ccgatagagg gattaatatg cccttcaccg gggaaaccga tcattaatac 1979581 attagccatg cggcagcacc cttcctttga gaatttatgt aatattttat acggtactat 1979641 aaatgcataa acaggtaaag tatttcactt aattaatatt catcatatat aacttttcta 1979701 ccagtttata ttccctgtct tcaagacaaa aagcattcag cttgaagcga atgctttaat 1979761 aaagatgcga attcagtcat tttgtctcat gataggattc ttaatcaggc cctttttatt 1979821 atttttacgt tcttggtgaa attaacggat ataatacacc gtctttggca aacgacatct 1979881 tccctgtttc ctctgaaacc acgagcacca gtgcatccgt atagcccgac ataccaagag 1979941 ccgcccggtg ccgggttccc aaatggatat ccacttcctt cgtcgtcagc gggagcacat 1980001 tggctgctga cacgagtttg ttttccctca ctaataaagc gccgtcatga agagggtttc 1980061 cgggaaaaaa gatgctttca attaatgaag agctgatctc ggcgtgtagg gaggtgcctt 1980121 tttgaataaa acgttcaacc gggtctgctc tttcaatcac aattaaagct ccatgcttat 1980181 gttccgataa ggctttaatc gccttggcca gctcaataaa tgccggcgta aattcctcaa 1980241 tgtatgattg caaataaaag gaggatgcaa tcccctgcat gtcctgaaaa acgtgcccca 1980301 aatcatctaa ttcacaaagg agacactggt ctttttcgtg aagcgttttc aagattagag 1980361 atgcatcacc taatatttgc tctaagtaca cctgtatttt ccccttgaac gcattttctg 1980421 atatctgctc atagcgcata gccttcatct cctgtttaaa tttccaactt ttcacgaatg 1980481 cttatcttat tgatgcacat tctattggta aaggagggat gtaaagaatg gaaatcgaaa 1980541 gaatcattca gtatatttgc acctttttag gcgtgatttc gctttctttt atttatgccc 1980601 aaatgtttag aaaaacgaaa ccgacaaaaa aagaataggc ccggcgttca ttgcttttta 1980661 tacataaaat gttataattt ctctcgttat gaaaaagaaa cggagatcaa tgtatgaaag 1980721 aaactcaaaa cgcccgggaa aaaatcaaac agctcttgca cattttaata ccgatattca 1980781 ttacccaagc ggggctttct ctgatcactt ttctagatac tgtgatgtca gggaaagtca 1980841 gccccgctga tttagctggt gtcgccattg gctcaagcct ttggacccct gtttacacag 1980901 gacttgcagg tatattaatg gcggtcaccc cgattgtcgc tcagttatta ggtgcagaga 1980961 aaaaacagaa gattcccttt actgttttac aagctgtata cgtggccgcg cttcttagca 1981021 tcgccgtttt agtgattgga tatgctgcag ttgaccttat tcttggccga ttgaaccttg 1981081 atattcacgt gcatcagatt gctaaacact ttttaggctt tttatcactg ggaattttcc 1981141 ctttatttgt ttacaccgtg ttgagatcat tcatcgactc attaggaaaa acgagagtca 1981201 ccatgatgat tacactcagt tctcttccaa tcaattttgt attgaattat gtatttatct 1981261 tcgggaagtt cggaatgccg gcacttggag gtgtaggcgc gggactggca tccgcgttaa 1981321 cttactggtg tatatgcatc atcagttttt tcattattca taaaaacgca ccgttttctg 1981381 aatacgggat ttttcttacc atgtataagt tctcttggaa agcatgcaaa aatttgctca 1981441 aaatcgggct gcctattggg ttcgccgtgt tttttgaaac gagcattttc gcagctgtca 1981501 cgcttctcat gagccatttt catacagtga ccatcgcgtc ccaccaggca gccatgaatt 1981561 ttgcgtctct tttatatatg ctgccgctta gcgtgtccat ggctctaaca attgttgtcg 1981621 gatttgaagc gggtgcagcc cgttttaagg atgcacgctc atatagctta atcggcatca 1981681 tgatggcgat cggcttttct ttgttcactg ccgcctgtat ccttttattc agagagcaaa 1981741 ttgcgggcat gtacacttct gaccccgatg tgctccggct gacacagcac tttttaattt 1981801 atgcgctatt ttttcagctt tccgatgctg ttgccgcacc gatccaggga gcactcagag 1981861 ggtacaaaga tgtgaactat acgcttgcgg ccgcttttgt ctcttactgg gtcattggcc 1981921 ttccggtcgg ttatatggtc ggtacgttta caagcctcgg tgcattcggc tattggattg 1981981 gattaatagc gggactcgcc gccggagcag ttgggctgtt tttcaggctg gcaaaactgc 1982041 aaaaacgtta ttcgcaaaaa caacacattt aaaagaggtg atcaatcatg gcaaaaaaca 1982101 aaaaattatt cgagtatctt tcccagcatg cggaaaccat cagttcaaca tggtatgaaa 1982161 caatcgagga gactgatccc aattccattt atgcctcaac agaccctgtt gtcattcaca 1982221 atttaaagag ccagaatctt gcctttaact ataaaataaa ccgtattttt atagatgatg 1982281 aggacgtata cttgcctata ctgaaagaat gggcctttga agtcacacag gatcaagagc 1982341 atttaaaaac tcctatccac tatattattc gggagtttgt cagagtgaga gatttatatg 1982401 tttcttatgt gaaagaattt gtccatctca atcagaatac tgtgaaaagc gaagaagccg 1982461 aagacctgta tcacgccctt ataaaagcgt ttgatcttgt gattcatatt tttatagaag 1982521 aaatgtacaa aaacacaagc cttcagcttc aggcccaaaa agatatgatt actgaattga 1982581 gcgctccggt catcgtgctg tttcacagcg tcggactgct gcctttaatc ggagatattg 1982641 atacagtccg cgccaagctg attatggaaa acacactgca tcaatgtgcg aaaaaaaagg 1982701 tgacacaact gtatattgat ttgtcaggag tagctgtgat tgatacgatg gttgcccatc 1982761 agctgttcag tctgattgag gcgcttcgtt taatcggtgt ttcttcaact ttgtctggaa 1982821 tccgtccgga aatcgcgcaa acagcggttc agctaggttt gtctttcgaa ggtatttcct 1982881 tgagatccac tctcgcttca gctattgcat cggacttaaa attaaaaaag gtataaggct 1982941 taaggcctta tacctttttg attaatcatt ccattgatac gtccaatata tttcttcttc 1983001 aaaccatgtt gccataacag gttcattatt tttcaatttc tcttcaagct ctctgagcat 1983061 gccttctgtt tgtgtgcggt gagctcttaa cgcattcatt ttaatatcag ctacttcttt 1983121 gatatcaagt acgacatcag cttcgccgag aacctcttct ctgttgcggg taatggccat 1983181 gcagattgta cgcggacggt cttctttctt tttgcggtat aatgcacgga taaccgcttc 1983241 cccgcatgca tcatggtcag ggtgcacacc gtgtccggga taaaatgtga caattaaact 1983301 tggttttaca tcatctatga tctcttccat gatatcagct aaatactcat cgtcttcaaa 1983361 ttcgagcgtt ttgtcacgga gtccaagcat ccgaaggtca ttgatatcca tttctttgca 1983421 agcgttgatg agctcttgtt ttcttagcag cggcaacgtt tcccgattcg cgaaaaatgg 1983481 atcgcccata tttctgccca tttcacctaa agtggcgcag gcatacgtaa cgggaatgtc 1983541 tttttttctg tttaaggcaa tgaggcctgc cactccatat gattcatcat cagggtgagg 1983601 caggattact agtacatgtt ctttcattat tattcaccct tttctttaaa ctgtgaacgg 1983661 tttttcgctg atttgcagag aaatagccag tttaccgccc ggcaggtgtc ccgccattaa 1983721 taaacggttt tcttcatcta ccgtgtattc agtcaagcct tcagcataaa tccagccttc 1983781 ttctgttttc aagccaacgc ggtaaggccc gttgcctttg atttttgcct gatgataagt 1983841 gacttttgca ttgcgaatat acgcaacaac cgtcatgttc ttttcattta agtgcgctga 1983901 ataagaacct gtggtggttt ctaaatggat atatacaggg cggtccgcat atcgttctaa 1983961 agatgcttgc acatcttctt ttatgatcgc tttcatgatt gctcccctct ttcttctttt 1984021 aaatactctg cacgttctgt atgtaatttg accagctgat atttcacagc cggttcgagc 1984081 tgtgaattca caatgcgctg aatcgcggca aaatattttt ccagcatcgg ttttcggagt 1984141 cttggatgtg ttcgtttatc caagagctca agatcaatcg cctctgctac cgcttctgcg 1984201 tcatcatgtg cgagagatcg gttattccaa agtgaagcat aggctttcac tatctcttta 1984261 tcattgtcca tcgtcttgct cctttatgtc ttacatacat gaaatgatta tacataatat 1984321 atgcatcagc tgaaaagcca aaggcctcaa tggctttttg acgcccgttt ccacttcact 1984381 tgtgaaaacg taaacaagag cagcgcagcc catatacagc tgaatgtaaa agccttcgag 1984441 cttgaaaatg gctcatggta aacaaacagc ccgatcagca gggtaatggt cggcgcaata 1984501 tattgtaaga taccgacttg atacagtggc agccgtttcg ctccttccgc aaacaataag 1984561 agcggcaaag ccgtaaacac accggccaaa aagagaagca gccacgtccc tccgctttct 1984621 gcacccgctg gctgaacatg tccgctgaac agcaaatacc ccaatgcaat gggcataatc 1984681 atgaatgttt ccagcgttaa accgatggcg ctcggcaggc ttgttctttt tttgcttaac 1984741 ccgtacagcc caaagctgaa tgcgagcaga agcgcaacat aaggaatgga gccgtattgg 1984801 aacgccgaga tgatgacacc ggctgccgca atcgaaacgg ccactaattg caggcgattc 1984861 agtttttcct ttaaaaataa aatcccaagg agcactgata caagcggatt aatgtaatag 1984921 ccaagactag cctcaagcaa aaagccatgg ttgacagccc atatgtatac aaaccagttg 1984981 atcgaaatca ggatagaagc aagaaataaa gagaggatcc ctccgttctt tttcagagag 1985041 cgcaactcct gccatcctat tttccattgc cgcaagaaaa aaagtacgat acacataaaa 1985101 acaaaagacc atataatacg atgagccaaa atatcaagag ccggcagctg ttcgagaagc 1985161 ttccaataga gcggaaacag gccccacatg ataaatgaaa cggctgtgta aataacgcct 1985221 ttttttgttt ctgcatgttg cattgatatc cctgcctttc tttagagcat cttatattat 1985281 atcacgtgaa agatctggtg ggcatatact attttgtccg tgaagaaagg atgtgaagac 1985341 aatgtttgag tggaacaagt actttccttt ccacaatcaa ttttctaaag aagcattaaa 1985401 aaaagctgat ccgaaagaag ttgaaacgta tgtcaatcgt gtgatggaaa gtgtgttcgg 1985461 cagtgattat gcggctcaat ttcctttccg cgatcctctc ccccaaaaag aacatcccgc 1985521 caaacctgat gcaaaacctg atgtcaaacc tgatattgat atattcgaaa cagcagacca 1985581 tgtgtttgta aaggtgccaa tcagcgaaga atggctggaa caagtgagaa tcaaacacac 1985641 atctcacgaa ttatggttgg aaaacctccc aagagcagat catccgaaaa aagtaaacct 1985701 tccttgttta gtcaaacgca aaggaacaaa agccgtctat aaggatggcc ttctggaagt 1985761 catgtttcaa aagcagcaag actacaatat gtccgaggta gaaatcatcc gataaaaaac 1985821 ggcctgcaat cgatgcaggc cgttttttat taatagaagc cgggatatcc cccgtatggc 1985881 acgccggcac caaaaccgta cggtccgcct ccatatccat aagggccagg aggataggca 1985941 tagggacgag aatagttaaa cagcgcactc ccgagaaaac cgcctaataa accgccgact 1986001 agaggagcgc caaacaaaaa aggactacgc gccggatatc cggctggacc tgggattccg 1986061 cgtaaatacg aatgatgagg gtacatgatt ttttcctcct ttatgtctgc ctatacgtaa 1986121 agtattcagc aaggaagaaa aacgattggg ctacggactg tctatgattg ttacatcaca 1986181 agccctgcca ataacacaca gccgagccct gtaaccgaaa gaactgttgt aagcagcgtc 1986241 caggtttgaa atgtttcttt catgctcaag ccgaaaaatt cctttaccat ccaaaatcct 1986301 gcatcattta catgacacgc aatgacactg ccggctcctg ttgcaagcac cattaacgca 1986361 gggtttacac tgccagcctc cataagcgga gctgccattc ccgctgtggt aagcgcagcc 1986421 acggtagcag agcctagaca cagacgcaga accgcggcga tggtccatgc aacgaatagc 1986481 ggcgacatgt ttgtttgacg gaaaaaatca gcgacataat cgccgactcc gccgtcaatc 1986541 agcacctgtt taaacgctcc tccccctcct atgatgagca gcatcatcgc aatttgcgaa 1986601 attgattctg aaatagatct gccgatttcc tgcatagata ttttacgggc atatcccatc 1986661 gtatagagtg caagcaacag cgaaatgagc attgccgttc ccggagtgcc gataaattct 1986721 ataatgtctt ttccttttga atgttcactc aataataaag aaaaaattgt tgccattgcc 1986781 ataaagataa ccgggaataa agacgtgaca gcactgatcg caaagcccgg tgtttcatcc 1986841 agctgaaatt ctttccttgg tcctaacccc gataggtttc catgcttttg atacgcacca 1986901 ggaaaccgtt tcatcgcaaa tttattaaat aaaggcccgg caatcacagt tgtcggaaca 1986961 gcgatgatga ttccaaaaag cagcacctgg ccaatatggg caccatatgc aactgagata 1987021 gcagttggag caggatgcgg gggcaaaaat ccgtgagtaa catttaaggc ggcggccatc 1987081 gggattccca gatacagaaa aggcattttt aattctttag caatcgcgta aacaatcggt 1987141 atcaacagaa caagaccgac ttcaaaaaat agggcaatcc cgatgataaa agaggcaacc 1987201 acaaccgccg cctgtattcg tttcctcccg aatttgtcaa tcagcgtaat ggcgatccgg 1987261 tagccgcccc cagcatctga gacaagcctc ccaagcatcg cgccaagtcc aaacactaaa 1987321 gctaaatgcc ccagctgccc gccaattcca gtctcaattg aaagaacaat tttattgata 1987381 tccattccaa gtccgatggc tactaaaaat gaaacgacaa tcagtgagac aaaggtattt 1987441 aattttactt taataatgag aaataacaga atcagcactc cgacagctac aattaaaatc 1987501 ggcatggtac ccctccaaaa gtgttttata tgattctcgc gacaatgttt tggcgctttt 1987561 catgcctaga tgaacagaaa gcgctttcat taataactaa aaacgtcttg gttatatgat 1987621 tgttatcttt tgatcaacta atatgttcat actaatctcc taatcaatga ctgtcaatcg 1987681 tttttatgag cttgtctcga ttacctaccg cctaacccaa tgatttatta gttatatgtt 1987741 gattaacttt tggttatatg ttatgttttt taaagttgac tgccaatcat tatatctctc 1987801 cattgtctgg aagcaaatga gacaatatga gaacagacgg ataacaactt cataagagga 1987861 ggagtacaca tgccattatt gcgttttgat gtaattgagg gccgtgatga aaaatcgctg 1987921 caattgttat tagatactgc tcaccaagcg atggttgaag catttggtgt tccggaaaga 1987981 gaccgttatc aaattgtcca tcagcatccc gcaaacgagc ttataatcca ggatgcggga 1988041 ttagggtttc agagaaccaa ggatatggtc atcattagca tgacaagcaa agcaagaacc 1988101 gaaagccaaa aggaaaaatt gtatgctctg cttgctgaaa ggctagaaaa aaaatgcgaa 1988161 atttcccctg acgacctcat ggtatctatt actgagaatg gtgacgcaga ctggagtttc 1988221 ggtctcggtg aggcgcaatt tttgaatgga aaactataag atttcgtctc cccacaaaaa 1988281 aaagaagaga gagctccaaa gaagctctct cttttttcat aaatgcggaa gtcatcagta 1988341 tagaagcatc cagcaatacg aaaaacctgg atctcctttt atatccggtt taaatgccaa 1988401 ttggaagctg actgggtttt ggctgaaaat ataaaatttt gctgatttgc ataataagat 1988461 acatcataat ccccatttac aataggttgg atgttatagc ttattgatca tttcctattt 1988521 tatatatccc cttcatatgc acatgacatt tttgccaatc cggaaatatc agtctgacaa 1988581 atataaaaag tcatgtaaac gggtgtgaac cgtacttaca tgactcacca tggaaacaaa 1988641 ggctcttttt caggtgccgc tttccttatt tctcttcttc acacactgtg tcaccaggct 1988701 cgcaaaattg atcggcccat gcctgcattt cttgaaatac agcttgaagc gctgttcctt 1988761 tttcagtcag cgtgtagatg actttgaccg gcgtttcagg gagaacctgc cgttcgacaa 1988821 tctcgttttg ttcaagctcc ttcaagcgct ctgccaacat tttttggctg atcatcggta 1988881 ttgtttccgt tatctcttta aaccgtttcg gcccatccat tagcacatgg atgatcagac 1988941 cgttccatcg ttttcccagc aatgagaatg cggattccat tttagggcac atcgtatttc 1989001 ccataagtct tcatcccttc atctattgat tgacatgtat tcaatgatcc attacaataa 1989061 tctttcaagt tacatttagt aagcttctaa cttttctatt atcataccac gtttatccga 1989121 aggaggaaac actatgacga atactctgga tgttttaaaa gcacgtgcat ctgtaaagga 1989181 atatgataca aatgccccga tctctaagga ggagctgact gagctattag accttgccac 1989241 taaagcgcct tctgcttgga accttcagca ttggcatttt acagtattcc acagcgatga 1989301 atcaaaagcg gagcttcttc ctgtagcgta taatcaaaaa caaatcgttg agtcttctgc 1989361 tgttgttgcc attttaggcg atttaaaggc aaatgaaaac ggtgaagaag tttatgctga 1989421 attagcaagc caaggctata ttacggatga aatcaaacaa acattgctcg gccaaatcaa 1989481 cggtgcttac caaagcgagc aattcgcacg tgattccgct ttcttaaatg cttctttagc 1989541 tgctatgcag cttatgattg ccgcaaaagc aaaaggttat gacacttgcg caatcggcgg 1989601 atttaacaaa gagcagttcc aaaagcaatt tgatatcagt gagcgctatg ttccggttat 1989661 gcttatttca atcggcaaag cagtgaagcc tgcgcatcaa agcaaccgtc tgccgctttc 1989721 aaaagtatca acttggctgt aaggatatga aaaaccttag tccgaaatcc ggactaaggt 1989781 ttttttatac aatcgcctct ttgtaccatt cacgagcctg ttcagcttca tgctgagtca 1989841 gctgatggcc cccgtcctgc cagtaaacgg aggctgatgc cccgctgtca cgcaaatagc 1989901 ggtaaagctc ttctgattct tccttcgtgc aaagaggatc gtatttcccg gcaccgataa 1989961 aaacagggag ccccgccata tcaggcagct cgataccccg aatcggaacc attggatgat 1990021 gcagaatagc cccttttaac acatctttat aatgaaaaag caggcttgcc gcaatgtttg 1990081 cgccgtttga ataaccgact gcaatcactc ggccgcgatt aaactgatgc gtttctgcag 1990141 cctcgtcgat aaaatctttc aattctcttg tccgcaccac aagatccttt tcatcaaaaa 1990201 ctccttcact cagacgtttg aaaaatcgcg gcattccatt ttcaagcacc gatcctctga 1990261 caccaagcaa atgggcatca gggtctataa accgccccaa tgaaagcaga tcgtgttcat 1990321 taccacccgt gccatgcaac agcaaaagta cgttgtcaga tgttcctttc tcataaatat 1990381 gcttcattat aaattccccc ttttaaagtt caggtaaaat gtctgtaatt tgttgtctat 1990441 gtttctccag ccattcaggc agttttaagg aagtccctag ctcagcaaac gtttcatctg 1990501 tcataaagcc cggttcatct gtggcaattt caaataagat accgcctttc tccctaaaat 1990561 aaactgatgt aaagtattcc ctgtcgagaa tttctgacga aggcagatgg ttttcagcaa 1990621 taatcggcag ccatttcgcc tgttcctttt tcttagtccg aaacgctaca tggtgtaccg 1990681 taccatatcc tccgactcct cttttttcag gatgtaaatg gacatcaatg acaccgccga 1990741 ccgccgctga agatgccagt ctgacaatct ggtcttcttc ggccactttg gtgtatccaa 1990801 agctttccgt taacaattgt atggtcgcct gcgggtcgta ggaatatagc agcacacctt 1990861 tcattcccgt aattgcttca tttgttgtga tcccgtcagg cgtccactcg cttttgccgc 1990921 ttttcgcatc ctccatgatc gccagcggaa ggtcttctgt atcatcaaaa ataagacctt 1990981 tttcaccaaa caacgttttt tcctctaggc tcagcccgct tttctcaaga cgttccttcc 1991041 aaaaagacag ggagcctgag ggaactgaaa agtacacccg gcccgcttgg ccttttccta 1991101 ccgttccctg tccgcttcct tggaacggaa aaaaggtcat tattgtaccg ggatctccgt 1991161 tttgattccc aaagtaaaaa tgatacgttc cgggatcatc aaagtttact gtttttttaa 1991221 cgagcctgag cccaagcact tctgtataaa atcgcaagtt ttcttgcgga tctctggcga 1991281 atgctgtgac atggtgcaat ccttctgttt tcattttctc actcctattt atctcgattt 1991341 caagatattt attattttaa acctttattg aaaaggatgc aaaccatgtg ttttgattaa 1991401 ataattgaaa aaatcatttt tttctaataa ttatcttgtg atcttttctt acaactgcta 1991461 ttatagtgag cattatcatg tttcaggagg aaagtaaatg gttaaaaaag cacttattgt 1991521 tattctcatt cttttgccat tcgttcagct cgcgcttttg ccgcttgtga atcgaataga 1991581 accgattatg ttcggcctgc cgtttttcca cttttggctg ctgctgtgga ttattgttac 1991641 gccgttatgc tcgtttggca tttatcagat gcaaaaaaaa gatggaggac ttgaataatg 1991701 caagggaatc tgactgcact tctcattact gctattattg ttttaaccgt tgtctgtatc 1991761 ggctttctcg ccggaagaga caaatcctca cgtacttctg tggaagaatg gtctgtcggc 1991821 ggcagacgct tcggcggtct tctcgtctgg tttttagtag gcgctgacct ttatacggcc 1991881 tatactttct tagggttgac cagtactgct tttacaggcg gaagtgttgc atttttcgcc 1991941 attccttatt ctgtgttggc ctactttatc gcctacttct tcttgccaaa actttggaaa 1992001 gttgcgaaaa ttcataaatt aacaacactc gcggattatg cccgggaacg ttttaacagt 1992061 aagcttttgg caagcctcgt tgccatcgtt ggggtactca tgcttattcc gtacatatgc 1992121 cttcagctga gcggcattca agacacgctt caggttgccg gcactggcta tattaacgta 1992181 aaattcgttg tgatcatttc atttattctt gttgctcttt acacattctt cagcgggatt 1992241 aaagggccca catatacagc catcattaag gacattttag tatgggtcat tatgctgttt 1992301 atggtggtgt ccctccctct cattcatttt aacggctgga cgccaatgat tgacacgtta 1992361 gtgaaggaag cgccgcaaat gctgacgata ccgtcagaag ggccaaaagg cattccttgg 1992421 tttatcacag catctattgt ttccgctctg gcacttttta tgtgggcaca tgccgctaca 1992481 ggtgttttca cggcgaaaag cgctgatgca gtaagaaaaa acagcatgtt tttgccgctt 1992541 tataatatcg tgttaatttt ggttattttt cttggcttta tcgcctttct tgttctgccg 1992601 gaagatacaa atccaaggct ggcgctgctg catttgattc aaacatctta cggcggcgtg 1992661 gcacaaggct ttgcatatgc cactatcgct cttgcttcat taataccttg ttccattatg 1992721 gcaatcggcg catcgaattt attcgccaac aacctatacc gggatttgat tcatccgaat 1992781 gtgtcgcaaa gcaagctgac tcttgtcaca cgttcaatgg tgtttgttgt catcggtctt 1992841 gcgctgctgt ttggaatgct gttcccgact gccttagtga cacttcagct attaggtgta 1992901 tccggtatgg tgcaaatctt ccctgcgatt gctgtcagcc tgttctggaa aaaccaaacg 1992961 aaagaagcaa cggttatcgg attattagcc ggcctagcgg taacgtttat tgtgtatatc 1993021 actcaatccg cacatggcat ttatgaagga ttctggggat tggccgccaa catgatcgct 1993081 gtggtcatcc tgaatccgct gttcgttaaa aacgcgggat ccaatcctgt cattgaaggt 1993141 ttatttggca aaaaacaaga cgctaatcca aatcaaaagg gcgcataaaa aaaccatacg 1993201 cggcagccgc gtatggtttt ttttacattt cttttttcag tgtttcaatt gccttttcca 1993261 tttgcgtatc attatcagac agcttctttt gaagttctat cattaatttc gttgttgtat 1993321 cgccagtcag tatgcctgtt tcattcagct tctctttttt ctggaactgt ttgacgacag 1993381 atacaaaatc ctggtcatac atactgttaa cctttacctt gtaaccaagt gctttgagca 1993441 ttttctgagc cactttgacg tttgtgcctg tatcacctga tttgtacgtt ttatctgcgt 1993501 ccaaatacgg cagcttcgcg taatcaggca gctctgcttt cacttgaggc ttgatgcctt 1993561 ttttgtgaat ccattcgcca tcagcagtca gccatttggc aactgtcagt ttgacggtag 1993621 agccatcatc atattctttt gccgtttgta ctgtaccttt gccgaatgtc gtctcgccga 1993681 ttaacggtac gtttgacgat tcatgaaggg cagcggccat aatttcggct gcgcttgctg 1993741 taccgtcatt tactaaaacg acggtcggct tggtcacttt ccgttctttt tcggccttca 1993801 tgacttcttt tgaaccgttt ttgtattcaa cctgcatgat gtttttccct ttatcaatga 1993861 acaggttgct catcgtaatc gcctgttcca ttaagccgcc cgggttgcct ctcaagtcta 1993921 aaatatagcc tttggcgcct tttttctcta aactgtcaat cgcatctgtc agctctttag 1993981 ctgttgtttc agagaaagaa gtgatttgaa tttctccgat gttgttgtct ttcatctctg 1994041 aatagacagt ctctacagga atggtatcgc gcttaatgga aagatcgata ttccccactc 1994101 ccgctctgtt cagttcaagc ttcacctttg tgcccttttt gcctcggatt aaagcgacgg 1994161 cttcatttac attcatgcct tttacgcttt ttccatttac cttaatgatt tggtccctcg 1994221 gtttgatacc ggctttttca gcaggtgaac ctttaattgg ggatacaata aggatttctc 1994281 cgtctttctc ctctacttgg gctccgattc cttcaaaaga tgctgaaatc gtctcgtcga 1994341 atgatttcgc ttgctcttga tccatatatg tagaatacgg atcatccagt gattgaatca 1994401 ttcctttaat tgctccgtct actaatttgt catcatctgt tttttggtaa taatcacttt 1994461 tgatttgctc atacgcttta tttaatttgt cgaacttgct gtctcctgtg cttgctgatt 1994521 tttggcccag gatactggaa ttgcccgtaa taaataaagt aagcgccgaa gcgacaactg 1994581 cagtgatcag cacaataaaa aacagtttta attgccgttt caattaaaca ccaccttttt 1994641 cttcttacat tattatcatg gacgaattct tattcgtcaa ctcggagcag aaatgaaaga 1994701 gaaacgccct tcttttgctt ttcataaacc tatgtcttta tacgacatat gataaggaaa 1994761 aaggaggatt cgatattgag ccgatattta gaaatgctgt ccttattcgg tgtcgcaggg 1994821 gcgcacccag gcgggctggc tttttcaaaa gcggtcttgc aaaaggctgc accctctccg 1994881 gatcagccga ttcttgatgc cggatgcgga acagggcaaa cggcggctta tttaggacat 1994941 ttgctgtatc ctgtaacagt cgttgataaa gatcctatta tgcttgagaa agcgaaaaaa 1995001 agatttgcga atgaagggct tgccatccct gcatatcagg cggagctgga acatctcccg 1995061 ttttcttctg agtccttttc ctgcgtcctg tcagaatcgg tcctcagttt ttcacgcctg 1995121 acatcctctc ttcaagaaat ttcaagagtt ttaaaaccca gcgggatgct gattggtatc 1995181 gaagctgctt taaaaaaacc aatgccccct gcagaaaaga agcaaatgat ggatttttac 1995241 ggatttactt gcttacatga agaaagcgaa tggcataaac tcctaagatc ctatggcttt 1995301 caaaaaacag aagcgatgtc acttcttccg gaagacatgg aatttgaacc aaccacagaa 1995361 atggatttat cgcaaacgat tgatcccatc tattacgata cgcttcaaac acattatcag 1995421 ctcatgcagt tatatagtga gtacatgggt cattgtattt ttatcgcgta caagtaaaac 1995481 ggcgtatcgc cccctgtttt cgtccaacct ttttttccta tctatcatat gctgatagaa 1995541 agtcaggata ggaggggaac aatattggag agatattatc atctttgcaa aaaccatcaa 1995601 ggtaaagtcg tcagaattac agagagaggc gggagagttc acgtcggcag aattacccgt 1995661 gtaacaagag acagagtttt tatagctccg gtcggcggag ggccaagagg tttcggttac 1995721 ggatattggg gcggttattg gggatatgga gcggcttacg ggatttccct cggtttaatt 1995781 gcaggagtgg ctctggctgg tttattcttc tggtaagcat agaacaaatg ctagattcac 1995841 cagacacaat gaagcccgct tatctagtgt aagcgggctt ttcattttaa attttcttca 1995901 ctttttcaaa gtactcttca agcgttaaat cattatcttg gatgaccttt gcggcttttt 1995961 tgcctacata gcgcagatgc catggctcat attcatattt cgtgatatct tctttatttt 1996021 tcggatagcg aataataaag ccatatttat aagcattgtc ctgcacccat ttcccgtctg 1996081 ccgtgcttcc gaacgcttca tttagctcaa agccattgct ccggctcgaa atgtccatcg 1996141 caaggcctgt ttgatgctcg ctttcacccg ggtaagcgac cgcttccttt gccttccttt 1996201 ccccttttag gcttacttca ttgtcaaaaa tgactttctg tctgtcatac gaacggtacc 1996261 ctgagacagc tgccagttca tagccttcct ttttggcagc atcgaacatt gtttttaatg 1996321 cgtcggccgc ttcttttctg atgtaacgtt tttgaatctt ttcttcaaaa gaaaactcta 1996381 catcaggtat gacaagatcg ctaggttcat agtttccggg cagtgcatat tgtttattga 1996441 caagcgcgag tatattttct ggattttgaa tggtttccag accatcgact tttttaatat 1996501 cattgaaata ctggctttcc aatgaaaact cactgttttg agtgtttgat tttttgctgt 1996561 cagctgtttt ttgttctgtt tgctttgttt ctgctgtggt tttcgtatcc ttttgagcat 1996621 ctccgttcga catgctgcag ccggctccga ctattgccgt tacactcaga gcggcagcca 1996681 gtgagaacca tttaccggac tttttcatat tacattacct tccttttatc aatcgtttcc 1996741 gcatgcataa agaagaggct gccggcaccc agcacgcctc ttgatatatt ttattgtgat 1996801 acggaatgta aagccacttc tatcatatca tgaaatgtcg tttgacgctc ttccgctgtc 1996861 gtttcttctc ctgttaatac gtgatcactc acggtgagaa ttgacagggc ttttcttccg 1996921 tgcttcgctg ctaatgtata caatgcagtt gtttccattt caacgccaag cacaccgtat 1996981 tttgcaagtt tttcaatttg cgaatcgtca ttgtagaact ggtcagctgt aaatacgctt 1997041 cctacagtca ccggcacacc tttatccttt gcggcatcat aggcattttt taaaagctcg 1997101 aaatctgcgc aaggcgcaaa atcaacgctt ccgaaagcaa ctctgttcat ttgtgaatca 1997161 gttgaggagg tcatcgccaa aatgacgtct cgcactttga catctttacg aatagcgccg 1997221 caggaaccga ctcttattag attttgcaca tcgtagcttt gaattaattc attcacataa 1997281 attgaaatag acggaactcc cattcccgtg ccttgtactg agattttttt acctttatat 1997341 gtacccgtaa atccatacat gcctctgact tcattgtagc attctacatt ttcaagatac 1997401 gtttctgcaa taaattttgc tctgagagga tctcccggca aaagcacagt atccgcaatt 1997461 tgtccttttt cagcacctat atgtacactc atctcatatc ctcctgtaaa tctaaattat 1997521 catccagccc gtccatttta caacgaatgt catgatgaaa caaacttcag cattgattat 1997581 aaaggaatat atcgaaaaaa gaaatgttcg aggatctgtt aggcacttcc tcagaaaaac 1997641 ggataatcgg ggtgttaatt tgaaaaccta accgcaggaa ggaggggtgg gacatgggta 1997701 aaaaacatcg taaccggatc accggccaaa aaaagaacaa tcatatacct gaaaaagata 1997761 tcattgcagc tgaagaagca cacgggaaag aatattccgc tgccaaacgc aagccttaaa 1997821 actgcagaaa actgcgggtt tccgcagttt tcttttcatt atgtcgtttg tacaatcaga 1997881 cgattgattt tcctccagcc ggcgggaagc agttgataat atgttttccc ttttctgcct 1997941 tcatcaatca ggatcacgtc ccctgtggcc atgaatcttg catcataatc actcggaaca 1998001 gtgtcgaata cattaaacaa agagaatgct cttttcagca cgtcttgatg atcgctcccg 1998061 ttcagttcag ttcgatagac ggctctgtag cccttttttt cgccaaaccg gggtgtctga 1998121 aatattgtca cgtcatagga acaagacttc tttttaaaca cggataacat catcaagatc 1998181 ccctcccttt tatttcttta acatattggc gtttttgctg tgttttcctc tctctatttt 1998241 tgtcgaaacc gcttaatctt ttcgtcaaaa ccttttacta ggaaaaacag aagcaagccg 1998301 aggctaaagc ctcctaacac gtctgtcaca aaatgaaccc ccagatacac tctgcttatg 1998361 ccgactaaaa cagcaattac accggctatg atatatacca tttttttatg cttagacaaa 1998421 aacgggagat gtttcactaa aaagtaagca ataacaggat agacacaagc agcattcatg 1998481 gaatggccgc tcggaaaact gaaggatgat tcatgaacca gcggtgcaaa atcaggcctc 1998541 actctttcga tccattcttt taagactttg tttaacagcc gatctgtgcc gaatactaag 1998601 agcatcaaca ggccgtccca tgtttttctg tagaaaaaca tgcctgctcc aatgatgaca 1998661 attagaggga gcagaaaaga agaagcacca agatgcgtga tccccgtcat gacttcatta 1998721 agccatggct gacggatcaa aacagctgcc ttgcttattg cttcatctgc agattgaaca 1998781 gcatttgtat gaatggccgc agctagaatt aaaaagaaaa gaaacaaact aacgggcttg 1998841 tacaatttta accacctcaa ttttcacaga agtcatagaa catgaataat aaaaccggag 1998901 ctgaccgctc cggttttaag cctcactcat cttcatccag ctcttcatct atcatacatt 1998961 tttctatcaa ataatcaaag gtaatatcag cgatttcaaa cagctcatcc tcactcggta 1999021 tgtagccccg tcttgcaagc tctctgtaaa aaaattcagc gatttcttcc gtatcaatca 1999081 caagatctat ttctttcatc tccgtaccgc ctcctttttt atgttttatg aaaaaacagg 1999141 ctgaattata cccggtgttc taaacaattc tttcagtcat atattgaata aaaaacgagc 1999201 catgggaggc tgacgctatg attgctaaaa tgatggaagc actggacgga gaaagatttg 1999261 atatcataat ggaaaaaacg ctcaaaggaa tgacgcgtgt gatgatttgg ggctgtctgc 1999321 catatttttt atatgtcttg atccgtatgt tcacaaatta actgaaatgc tcttttaaac 1999381 tttccaaaac aaacatcatc atgtctttat attcttcatc ctgaaacatt tcgtacagaa 1999441 ttttgtagtc attataaata tccagaagct catcaacaat tgacacagca aggatgtgaa 1999501 gggtatcttg atcttcatca ccgccttcaa actgaagaag agcagacgat gcgatatctt 1999561 cgccgatctc atggccagtt tctccgacat aatggacaaa caacagctga tgcacaaact 1999621 ggtccatttc atattttcta agcaccagcg tgagatcctc ttcctccgtt tcaagccact 1999681 ctccatcctt taaacgggtc agctcataaa tgatatcttc ccagccatct tctaaatatc 1999741 tccaaatttc tgttctatgg ccgataatgc gaaagagttc ttttccataa tctttaacat 1999801 aaacaacgtc cccaataagg aattcatact caatatcaag cttctccatg tcgacaatga 1999861 caccctcata atctttataa agctgaatag atgattcaaa gtataaaact tcgttatgat 1999921 tgacttcata aagatagtgt ttatcaattt ggtgtacttt tgtgatggtg ccgactgttc 1999981 catacataat gacgactacg atatccccta cttggaattt cggtttattt tgcttcatgg 2000041 tgtctccccc tcgccgcaac atttctcata cgctatcgta tgccgggtga agccaattcg 2000101 catgggcatg aaaaccaaag gaaatatcca attatggtat gggtatggac ataaaaaaat 2000161 ccgcagtgat ctgcggatga aacagctatt atctgccgtg cacttcagac tcgtattgat 2000221 cccaagcttc atcaaacgtc gccatcgtgt gaaggtaatc agcattcagc tccaaatatg 2000281 aactgatttc atgataatcg gttgatgttt ttggaaagct gtgatcctca tacgcctgat 2000341 tggcaaattc actgatgctg tccttcggct tagggtgtct gtatttcaat aaatagtgat 2000401 aaaaggattt catgggtttc ccctcctgat gtctgtcttt tgttgttcta ttatacagtt 2000461 caagtgtaaa attacaacaa aagaatactg aaacatgact caggagaagt caaaatagtt 2000521 gcgtttcaaa attctttctg tctccatgag ctgctgatat gtcaggcttt caggcagttt 2000581 ttttgtttga attaaaagca gctgatcctc aatctcttta accgtgtttt cctcttgata 2000641 ggtcataccg caggaagaac ataccatggc aggggtgtct gtcagttcta tagccctcgt 2000701 tccatcaggg agctcccagt acaccgtgtt cctgccgggc accgcttcga gctcgccgca 2000761 ccattcgcat gttttcatga agaatcccct ccgcattcag tctctttctg ttttttctgc 2000821 tgcgccaaaa atttcttttc tttgagctga tctcttttct cacgccgatc ttttaatgtt 2000881 tcatgctccg gatttgcgat gtatgcctct ctccttttga ttctgtctac attttcaggt 2000941 gtaaacgaaa cttctttgtc agcaaaaatg gcactcagcc cgatcggctc ctttttgtca 2001001 gcggtttcag ggaaaacgga ctcaaaatag gcgtctgcct gattggggat ataattctct 2001061 ggttccggat atgacgtaat cacaccttca aaatttctta agatcacttt gtcaggactt 2001121 tgtgacagga catagtttgg ctgcagggcg attttacctc ctccgcctgg tgcgtcaacg 2001181 acaaaggtag gaaccgcata gcctgaggta tgacctctca gcccttcaat gatctccaaa 2001241 cctttggaaa caggagctct gaaatgccct attccttctg acagatcaca ttggtaaata 2001301 taataaggac ggactctgat ttttaccaag tcatgcatga gctttttcat aattggaacc 2001361 gaatcattaa tacctgctaa tacgacagcc tgatttccga ccggcactcc cgcgttcacc 2001421 agcttttcac atgcctcaac ggattcttct gtcatttcga tgcttgtgtt aaaatgggtg 2001481 ttcagccaga ccggatgata ttttttcaat atctcgcaca gatgatcggt aatgcgctgc 2001541 ggaaagacga cgggagctct tgttccgatt ctgatgactt ccagatgcgg aatgctgcgc 2001601 agctctttta aaatatattc taaaatttgg tcgttgatga gcagcccatc accgcctgaa 2001661 attaaacaat cgcggatttc gggtgtttcc cggatataag caattgcagc atcaagctgt 2001721 tttttgggga cgcccattcc gatttgtccg gaaaagcgcc ttcttgtgca gtagcggcag 2001781 tacatggaac attgattcgt gacaagaaac agcacacggt cgggatagcg gtgtgtcaga 2001841 ccgggtaccg gtgaatcttc atcctcatga agcgggtctt ccagatcgta ttttgttttg 2001901 tgcatttctt cagaaagcgg cacagactgc atgcgtaccg ggcatctcgg attgtcgggg 2001961 tccattaaag aagcatagta aggtgtaata tttaagggga tcgttttggt agaaattctg 2002021 acgccttcct cttcatcctc ggtcagatta atgactttct ttaaatcatc taacgttctt 2002081 acagtgtgtg tcagctgcca aagccaatcg ttccatttct cttccggaac gtccttccat 2002141 aactcgatct ccttccaatg ccgtttcggt ttataccatt tgtttttcaa acgaactcct 2002201 cctcgcgcat attttgactt acagttgctt gcaccaaata ttcatgtttt caaggccttc 2002261 ggctataaag caattattga tcagccttcc gccatactga taacctgaat ggtacaacac 2002321 agcattcatc ccaaaagacg aagcacgggc gagagaaaac acatgaacga tatcctctcc 2002381 agccatttct ttttctaacg cctcgattaa aaagcttgtt aacgaatggc cgcgatattc 2002441 cggcagcaca gcgcaatcgg ttatttctgc atgcccaagc tctggattga tttctgcgct 2002501 tgctgcgctg atcaggcggt catgatcaag catgatataa tacaccgtat ttgcattcat 2002561 cgtcttttca atataagcgg ggtcaaatac cggggttggg tacgtgcgga atactttttt 2002621 atacagcatc gatagctggt acatgtcgtt tgtttctgct tttctcatcg taaaaacggg 2002681 tgtactgtcg ttgcgaagac ggggcgctgt gcgatatatg gcttcgatga tctcctgttc 2002741 ctctgtataa gaatctgttt gtctccggct ttctgaaagg taacgtacca tgacacaagc 2002801 cgaatggccg agataatagc cctttagata gccctccggc gcaaataatt gtttggcaag 2002861 gatcggctca tcatgctgct tcgcatagac aatgattttt tctgcattct cttcttttgc 2002921 cgctgccacg atatccggca gggccttctc aatggctccg tcataacgaa ccactctgat 2002981 tcgtttatta aagccgtcat ggtccaaaac tgctgtgaca ccgctactct ttattgactt 2003041 gagcatccgc atcctcccca tctgtatgaa ggccgcacca atccatgaca aaaagtgcaa 2003101 taattttagc agattctatc atggcttcaa cctcaatgta ttcattggcc tgatgagccg 2003161 tttttgtttc ccccggcccg aaaacgatca ctggtgtatc tcctgcatgg tacaaaagcc 2003221 ctccatccgt tccccacggg gaagcctcaa taatcggctc tgtctgtttc attttttgat 2003281 aggctgattg cagcacagaa attaaagggt gatcatcagg taaatcattc ggcagccatt 2003341 gagcgccaaa ccattcgact tgtacgggat ggcgtttaaa ccattcgtca tggtattcta 2003401 aatccttcag ccagttttcc aattcaagtt ttacagcttc tggtttctca tggggagcaa 2003461 ttccgcatct cccttctatg acgacacggt ctgcaactga agatggccag gcaccgcctg 2003521 agatggtgcc gatattcacc ggtaccggta ttgggatatt gtcatacagc ggatctgaaa 2003581 ttctcgcatt gcggactttc tccagctctt gtatcgctgt gataacgtgc atgctttttt 2003641 caatcgcgct taccccttca tagcgtgtgc ccccatgtgc ggataatccc ttcacagtga 2003701 tccgaaacca catcgaaccc tgctgcttaa taaatagttt catattcgtc ggttcaggaa 2003761 tcagcgcccc gtcagcacga tagcctctca tgatggcgga aagtgtaccg gcgccgccgc 2003821 actcttcatc tacaacactc tgaaacaata catctccctt cagtttgaca tcgcaggcgt 2003881 gcagggcttc taaagcaaaa agaagggctg tattgcctcc cttcatatcc gttgagccgc 2003941 ggccgtatat tttaccgttt tcttcgacag cttgatacgg ttcatacttc caatccttta 2004001 cgcttccttc aggcacaaca tcgatatggc cgttcaaaat cagggacctg cctccgccgg 2004061 ctcccgtttt tttagccacg atattcgggc tctcatgaaa atcggatcgg ttagatttaa 2004121 agtagggatg ctgttttaat tgctttatgc ttggctccca tacatcaatg tccatatgaa 2004181 attgccgcag cttttcaagc acaacagctt gggcgttaaa ctctgacccc aatgtgcttt 2004241 tttccccaat cagccttttg agaagacgaa tggctttggc cgaatgctga tcaagccact 2004301 cgattacttt tctttcaatg tcttgcatcc tcattccccc tcttaagaaa aaggcatatc 2004361 tattttgatt tcagcttctg tcagcctcgt cacctcatcg attgtcgagc cattcatcag 2004421 ctcttttaaa atgaagtgat ggctatcgac ctcaagaacc gctttttcgg taataatcaa 2004481 atctacacag cctgcagcag ttaatggcag cgtacatctt tctgttaatt taggccttcc 2004541 cttttgatct gtatgactca tgacgacaac cacttttttc gctttttggg caagctccat 2004601 cgccccgccc ataccaggca ccttttttcc cggaacaagc caatttgcca aatctcctga 2004661 ttggctcacc tgcagggcgc ctaaaatcgt aatgtcaatt ttgccttttc tgatcatcgc 2004721 aaaagacatg gttgtatcaa aataagaagc cccttttaca gcgcggacag gatatcccgc 2004781 ggcgttgcat aaatgcgcat cctcttctcc cttttcggga ctttctccaa tgccaaggac 2004841 accgttttcc gcttgaaaca tgacctgcat gtcaggcttc aaaaagttcg gtaccaagga 2004901 agggataccg ataccgagat tcacaatcat gccctgctta atttcagtag cagcgcgttt 2004961 tgcaatctgt tctctttctg ctactcccaa gcccatttcc acttcactcc ctcgcttcgt 2005021 acaaccccct caacaaaaac ccccggtgtg acaatcattt cttcagaaat ctcccccatc 2005081 ggaacgatac gctcagcttc ggcaaaggtt ctcctggcgg ccattgccat aagcgggttc 2005141 atattgcgcg cggttttgtc atacgttaga ttgccgaatt catctgcaat gtaagcattg 2005201 atgaaagcaa aatcagcagt cagcgcctct tcaatcaagt atcgttttcc cgccactgtt 2005261 acgatgtcct ttttttcgca aaccatttga ttatcaatgc ccacgtcggt taaaataccg 2005321 ccaagccccg ctccgccggc gcgaatccgt tccgcaagcg ttccctgagg tgaaaattga 2005381 acctctaacg tcccctctgt catctgtttt ccggctactg gattggaacc gatatgcgag 2005441 gcgatcaggg ttttgacccg ttgattaaca ataagcgggc cgattccgat atccgggaaa 2005501 ccggcgtcat tgcaaatcac agtcaaatcc gttacaccgc tgtccaatat cgcttcaatc 2005561 aatgaaggag gcgacccgac tcccccaaaa ccgccaaaca tcagaaccga tccatcccga 2005621 acatctgcaa ttgctgtgtc aatgctgatt gctttttgaa atggcgccat ttaatgtcaa 2005681 tcctttttta agtttttttc gaccgctgca actgtttctg aaaaaataga gataagctct 2005741 tccatttcac cgtctgaaat agtaaaagga ggagcaataa tgacagcatc tccttctcca 2005801 ctgtctattc cagctttgga aggataaaca atcagcccgc gttttttcgc ctcgctgaca 2005861 ataagctggg ttatcgcctg ctctggcgga aacactttct tcgttttttg gtctgccaca 2005921 aattcaatgc ctaatagcag tccttttccg cgcacctcac ctataatgcc gctttgagat 2005981 gccgcctcat caagcttctt cttcagcaca gcgccctttt tttctgattg tttgatcaag 2006041 ccgtgcttta acacatatcg caaaacttca agagcagctt tggctgaata gggatgtgca 2006101 ctatatgtgt gaccgctcat aatcacacct gacccttgtt ttatggtttc aataatagaa 2006161 tcagatacga cggcagcagc aataggtgca taccccgcac cgagtccctt ccccagtaca 2006221 gcaatatcag gtacggtatc ccaatgctct gtcgcgagca tccttcctgt tctcccaagc 2006281 cccgtcatca cttcatctgc aataaaaagc acatcgtgtg tgcggcatac ctcacttaat 2006341 ctctcataat atcccggagg cggagtaatc gctgctcctg cagcaccaat aataggctca 2006401 gccacaaagc cggcgatgaa ttggcttccg attcttttaa tcatggtgtc cagttcatca 2006461 gctgcagtct gaacaaagtc ttcttccgtc tcgtgattca gccgataaat atgtggagct 2006521 gagatagctg gataccgctc aatgagatgg gtgaaccggt atctcctttc ataaaaacca 2006581 gacaatgaaa gcgctcccaa agttattccg tggtaactgc tccatcgaga caaaaagatg 2006641 gatttttgtg tttgcttttt ttcctgccaa tactgaatgg cgattttcat agctgtttct 2006701 atcgcttctg atccgctgtt gacaaaaaaa gaccaattca catctccggg cagctcctgt 2006761 gccaagagag cggctaattg ctcggcgggc tcactcgtaa actgtgagcg gtaagcaaaa 2006821 gacacctgat caagctgttc tttcagcttc tcagtcacat cacgaactcc gtggccgata 2006881 ttacatgtca ccgcacctga cgagccgtcg agatattttt ttccggtctg atcataaaca 2006941 tatgaaccct tcgcataact gacaaccgga taggccgagc taagctctgg cttaatcaaa 2007001 taactgctca tgctcccacc tcaaaacccc ttttaccata ttgtatgagt gtccaaatgg 2007061 cggcatgacg ttccccgcaa aaactttttc acataaaaag agccttccta ataaggaagg 2007121 ctcttttgaa atttcagcat ctagcaaata aaagcggctc caacaataat taataaaatg 2007181 aacaagacaa caattaacac aaatgtattt gtcccgcagc caaatccgta accgtaccca 2007241 gagtatccat acatgctgtt ttcatccttt cttatcacga tatacgacat tttatgcggg 2007301 ccaagtccca aatggtttgt gcaaacgcct atttcatgta aggaaataat gaaatacagt 2007361 atgcacccgc tcatattttt taaacgtcag cttttcgtaa aactgagttg caccgtcagt 2007421 gcttgcagcc actaagtagg ctgcttccat tcctagtgat ttggcgatgg acagcatttc 2007481 tttcactaag atactgccgt agcccttcct ttgaaactga tctaaaattg ccacttcttc 2007541 gattttagcc gttttctctt gatgatcgat aaacagctcg ccgcacccaa tgggaacttt 2007601 ctgtgcctgg tcgctgtaac aaacaacaag aatgattata tctgcttcat agaaaggata 2007661 ttttcttttt aatttttgtt cagcgattgc ttctccaata taaatggaat cgtaaatttt 2007721 cataatagaa gatccgtcgc taagactttt tgccgtcccc catgcggtta aaggatgtcc 2007781 catctgcccc ttccagtcac taagcttcat gtcatatagt agctcatcct cgacgacaaa 2007841 accgcttttt acaagtgact gcttcaaacc gagcggaaaa acatgctgcg gcgacgcttt 2007901 taaatggaga taattcgcat caagcagctt tggtacggag ggtaaaaagt taagtaaccg 2007961 ctccaatgga aacgtatcat ggagctgaac aaagttatga gaaaaaattt gcggaagctg 2008021 cggatctctg tatacgctgt aatgatcaaa cgatgccgat tcagacgtta acaatatata 2008081 ttgatgttcc gtttttgaat aatgtcctgt catgaacgtc tcctttttat gacctatacc 2008141 tttactctgt tgcaatattc aatttcttta taatctcatc gtacaccgga taaaacggct 2008201 ttccaattgg aaattgctga atatttcgga aagaagcgga gattggcttc tgatgtaaaa 2008261 aaaacttcct tgttacttgt tcactaatcg ggtgaaagac gccgtttaga aacaaaaacg 2008321 gctcgcgttc gatgaaaaac agacgtcggc caggcggatt tttgatcaat tcagatcgtt 2008381 tccacgtaat cggcggccct tccggaagcg tctccatctc ttcttttcca attgtcacta 2008441 tgtcttttct ttgaaattga taaaattgaa acgcatactg gtccacaatt cgcctttttt 2008501 ttccggcttc gatataaaat attgcaggat ggtcagcttc ctttactaaa atataattcg 2008561 gaatgtttaa aattttgcca atcctatatt ggaataaata tgggtctgga acagcgacag 2008621 tccgatttag atacaaaaaa ccccactttt ctccaacagg atgccttaca ccctgatcaa 2008681 aaaaatacac attttgatct gaacctttta caaaagagcc gtcaatcaaa tcggcgggca 2008741 gaaaccgata tgcattttga aatgaatctg gggttttata ggttgtgtct aatacttcat 2008801 ttatcggcag aaatggggta aagttgttga gtctcgccca aaaaattgcg tcgccatgat 2008861 tccaatgctt catatcatca tcccagtagc ctccaaattt atggtgaatg agattaagta 2008921 acgaacggcg atgcataact gagcaatgat caacttgaaa agcggcctga tcaagcactg 2008981 cattggcatt tctgtagaaa tgtgagattt cctctcccct ttcgtttaca tgtacaactt 2009041 tttgttttga atagaccgcc tgcgcttcag gcttatgtga aaactcttgc accatacggc 2009101 tcagccgctc aggatgataa acagtgtcgt cagtaagata ggaaatgtaa tcgccgtctg 2009161 caaatgggag cgcactgtta attaatgtgg cataacgggc tgtttttaat cgatctgcag 2009221 gatgcacgaa actgttatga tattgaatgc gccggtcatg gagatacttg tgaatcaccg 2009281 cagttgtttc tgcattcgaa tgatcatcca tgataaaaag ctcccaaaga tcatgcgttt 2009341 gctgtatcac gctttcgatc gctttttgca aataatcggg tttgttgtaa cttgttaaaa 2009401 taatagacac tttctctccc atctataccg cctcccgccg tcaaacataa aaacggctcc 2009461 gcagcaagca gagcctctgt catcatttaa aaagcacccc agcttacaac acttgagagt 2009521 gaaacatgag atctcgtgtt atttaacggg ttttggaaaa taaccaaatc agtcagaact 2009581 tcttttacga tgacattttg aagtgtatct ccgttgatca aattgacttt tgaaaccggt 2009641 acgcccagct cttttgcaaa aacaagctgg cgtctgaggt cagatggatt tccttcagaa 2009701 gacgattgac gtatcagcag aatcagcaaa agcaaaataa aatgcagatc atcttggttt 2009761 tcttctcgat ccacttgttt ctctaaatcc aaatcatccc tctcccttat ccttatctct 2009821 gtttcacaat atgtgcgact tcgatttatg gtataggcta tgtccactcc attaaaaaat 2009881 cagcattttc cttaaataga tgaaaaatag atcaggtacg gcgttcgact cataccaaat 2009941 aacagccgga agaatatgaa taacgtgagt tcactatcga ataggaggtg tgtgtaatga 2010001 gctctgaaaa tgcacagtta aaaaaggatt taattaaagc cgttttaagc cctttatttc 2010061 caactgcaac agaaggagga gaaaatatgg atagtaatct taaagccttg cttgatgctg 2010121 ccatcgatca aaaagtagat gaaagtgaaa cggttacggc agaatctatt ttagaccctt 2010181 ctcttccggc aagatggatt tttgccagaa ttacgccagg cactacaatc agcattgtga 2010241 ctgattcagg tgacatgatc ggaccggttg ttttcgttgc tttcgatcag gttcacggga 2010301 tcgtatttgt aacacaggaa agctccgtca ctccggcagg ccaagctaca acattaattg 2010361 atgtagacaa agtagaaagc gttacgttct tttcataaca tccgatgaaa gtcttgtata 2010421 tccagtcggg atacggagga atatacagtt attttgatcg ctgggctgaa gaatgttttc 2010481 agaacactca tacagagtat atgattgcag ataaacctga agcagaatct ttgatgaaga 2010541 tcgaagcgtt tcagccggat ttcacactta tgatggttgg agaccgcgtt cctcacgact 2010601 ggctgacctg gttaaagggt aaggatatcc ccgtgtatgt ttggctgacc gaagacccat 2010661 tttatatgga tatcagcctt caggtaatta agcttgctga cgccatatta acgatagaac 2010721 aaaatgcagc tctctactat caagagctcg gctaccagaa cgtctattat gttccgatac 2010781 cagttaacca tcggctgttt aaaaaaatgg gcaccgaaca ttcctatcat tcaaatctgt 2010841 taatcatcgg ctatccttac cctaatcggg ttcagcttat gaaagaagcg gtccatctgc 2010901 cattcacggt tcgggtaatc ggcaaggaat ggggaaaata tctgcctaaa aaagtgctca 2010961 aacagccgca tattgatgtc gtcagcacat gggttccacc cgaacaggcc gttcattatt 2011021 ataatggggc agacatcgta attaatgcgc atcgtcccta tcattttgct ttcaaccaaa 2011081 atactatgcg catcaaaaat gccagtttta ataaccgaac gtttgatatc gctgcatgcg 2011141 aagcatttca attaacagat ttacccgcgg cgcatccttt ttcatccatt atttcttatc 2011201 acggcatgaa cgactttaag gaaaaagccg ctttctatat caaccaccct gaagaacggc 2011261 aaaaagctgc agcagccaat tataaagaga ccgtacccgc atttacgttt gatgagcttc 2011321 ctgcaaaact aaaagcgatt catctggcgc tttcttgaaa aatcgttcat tgctatgaac 2011381 gattttttta ttcatagaaa aaagcagctg cacaagctgc tttctattct agccgtcaga 2011441 acggtctttc agcttcctcg gatttacctg tttatgaaga tcaggcattt cgccgagatg 2011501 ctgtgcaatt tgttcccacg atacaatttt gaaattttga ttgacggctt gtccgttatc 2011561 aatattttcg ccgtcctgcg ccacaaaaat cccgtacgga tattttgggc caagtccgaa 2011621 accgagaaca tcaataccat ccgtgtcact agtaccgtct atcttctcgc catctgtaat 2011681 ctcaaagttg gctacatagc gatttttccc ctgccgttca tacattgcat agctgttatt 2011741 tccttgactt gaagccatga gatatccttt gccatttggt gcataataga ttgtcagtcc 2011801 ttcaatatca gctgtcaaat gatctcctgt cgcacggtca acaacctgcc cctttgaccc 2011861 tccgccgggc tcagcgttaa atttccagat ggcctcatct tcctctgcta tgtataggtt 2011921 tccgtactca tcatccgcaa caaggccttc ggtctgagaa ttcaacttaa attcacgcac 2011981 ctttttccct gttacataac cctttccacc atcaacaatt tcatactgct caaattcccc 2012041 ttgtttgcct gtcactaatg cgtaaaatgc tcctgttttc tggctgtgat acaagctgaa 2012101 tccataaacc tcagaaatat tggtggaaat aggatggttc ggatctgtaa tgcttttcaa 2012161 ttttccttta tccccgtcta ttgcatatac ttcaattgta ttttttcctt cggaccggtt 2012221 ggatgcggca gcaatatcaa ttttttcgcc gttcaatgga aaatcatagc gcagatcgac 2012281 attattgagc ttgccaaact cataagaatg aagctgtttt ccgtctaaat catacacaac 2012341 gagccctgac ttcttatttg ttgtaatcaa cttgcttttt tccgggtgtt tttcatgaac 2012401 ccaaatggcc gggtcatctg ctgcatcatc gccagatgcg accggatctg tctccgtgtg 2012461 tgcagtcact ttgaaatgat gttcctcatt cacataatga gccgacaccg aggttgctgt 2012521 caggctaagc aataaacccg cggcagtgct tagcagcatt gtttttggaa ccttcatttg 2012581 gtaccctcct cttttatcac taacactact attgtaaaat atatacaggt gattaccgtg 2012641 aggaaaatga accttttttt atagggtttc tgactcataa acaacttatt ccccaaagag 2012701 gtggtgagat gactttgcca gatttacttt tgcggagcga aataaaaata tgttgaatat 2012761 ttagtacatt atttatttag ttttgttttt ccctagttac gtccgttttt ccattttcta 2012821 ttaaaaaaga acactttgtg acatgatcat tcccctaaat tttgttttat tggttgcttt 2012881 cattaattcg attacaaagt tgaacatatg atgcatggta gagaaacgag agttggagga 2012941 taagccatgc ctaaacagca aacagcagaa ctaaaaccat ttttccataa caaaacagtt 2013001 ttagtcactg gcggaacggg ttcaatcggg agtcaaattg tcaaacgcct tttgatgctt 2013061 acacctaaac aggtgattgt attcagcaaa gacgacagta aacagtatgt catgagccaa 2013121 aagtatgcgg aggataagcg gctattattt gtacttggag atgtacgcga tcacagaagg 2013181 gtgaatcagg tgatgaaagg cgtcgatatc gtctttcacg cggctgcgct gaaacaggtt 2013241 ccgacatgtg aggaccatcc atttgaagcg atccagacca atctcatcgg cggacaaaat 2013301 gtggtggaag ctgccctttc acaccgagtg cagcatgtca ttaatatcag tacagataaa 2013361 gctgtatctc ctgtgaacac aatgggtgcc accaagctgt tatctgaaaa gctgtttcat 2013421 caagcaaacc gccacgtcca aaacaaagga accttgtttt gttcggtccg ctttggaaat 2013481 gttctcggtt ccagaggttc ggtcatcccc atattatttg aacagatgat ggagggtgaa 2013541 cctctgacca tcacagacaa aaacatgacc agatttttca tgtcaataga cgatgcagct 2013601 acattgacat tacaatcggc tgctattaca aaaggcggag aaacctttat tttcaaaatg 2013661 gaatcactga aacttgaaga actgattcat gggtttgaag aatatgcatc gcagcacggg 2013721 ctcccgcggc cggctgcagt agaagtgggc aagcgtccag gtgaaaagct tcacgaagaa 2013781 ttaacatctc cacatgaaat tgaatcactg tatgaatggg gcaaccttta tgcgatcctt 2013841 ccagagccgg aaaaacatcc tgactttcgc aaagtcaatc tgcctgggta tcaatcagat 2013901 caagccccgc tcattacgaa agaaagaatt gctcagatta ttgaagaatt gcatcaagag 2013961 aaaaaggcat aaaaacaagc ctgtctatcc attaggcagg cctgttttta acagtttatt 2014021 tattaaagag atgcagatag ctttcgtatc cttcttcttt tagcttatgc ttcggaacaa 2014081 accgcagcgc tgctgaattt atgcagtaac gaagtccgtt tggccccggt ccgtcattaa 2014141 atacgtggcc aagatgagaa tcagcagttc ggcttcttac ttctgtgcga atcatgccgt 2014201 ggctcgtgtc cagtttttct tccacttctt cttcaatcgg ctttgtaaag cttggccagc 2014261 cgcattggga atcaaattta tctttggatg taaacaatgg cttgcctgac acaatgtcta 2014321 catacaaccc ttcttcctta tgatcccaat attcattttg aaatggcggc tccgtgccgt 2014381 tattttgcgt tacttcatat tgcatgcgat ttaatgactt tattttttct tctttattgt 2014441 acgccattta tttagccccc caatgctcgc tgataaatcc cgctcgtccg gaacctgtcc 2014501 ggtagcgctg ataatgtgct ggattctttt tataaaaatg ctgatggtag ccttccgctt 2014561 catagaaagg ttcagctttt aaaatgtccg ttacaatcgg atctttaaag atgccgcttt 2014621 ccgccagacg ttgcttggaa gcttccgcaa gctccttttg tttatcatta tgataaaaaa 2014681 tggctgcgcg ataggaactg ccgcgatcag caaattgccc tccggcatct gtcggatcga 2014741 tttgctgcca aaataattca agcagttttt cataagggaa tacatcagga tgaaacgtga 2014801 tttgaacggc ttcacgatgt cccgtcgttt cactgcacac ctcttcgtac gtagggtttt 2014861 cagtatggcc gcctgtatac ccggacacca ctttttcaat tcccggctgt tcgtcaaaag 2014921 gtttaaccat acaccaaaaa cagcctcctg caaatgtggc gatttctttt ttttcagaca 2014981 tactggtgcc tcctttgtta atacgtggta ttattatatt atagcatgta aaaatagaat 2015041 gaaaatgatt ctgcttttca ataaaatcta taggttttaa gcaatatgct tatgtaatgg 2015101 aggttcacaa atttgaaagt aagaacacag atgatgtacg atatggaaac tttactccgt 2015161 aaagtcttta aacaaatacg caatgaaatc aatgaaattt tagataaaga gctgtcgcgg 2015221 aatgaattca ccattcttcg aatccttagt gaacaagggc ctaaaaaagt cactgaattt 2015281 gcgcctattt tagaggtatc ggcaagccac attacggctg tgaccgatgc gctggtagaa 2015341 aaggaatgga ttacgagaat cagatcgaag gaagacagac gcatcatccg cattcatatc 2015401 actgaagcgg gcgaaaaagt ccttcagcac tttaacgaga aaaaaacgga atatttcttt 2015461 aaacgctttg actgctacac tgatgctgaa cttgccacgt taatcgagct cttcagcaaa 2015521 cttgataaaa aacggtgaaa aaaagcacat accgatatat aggtatgtgc ttttcgcagt 2015581 gcttcactta tttttcagta aacagcttca ttgctttcca gcggccatat ctataataca 2015641 aaaatgccgc gcagctgcta aataaaaaac tcattccgat tccaagcccg attccttttt 2015701 gtccaagcca agctgaaaat agagctgtga aaggatacct caacacccaa aacgagatca 2015761 aatttaatac cagaacctgc agcatcgctc ccgcggccct gacgattccg ttcagcacaa 2015821 aattaacccc aataaaaggg tagaaaaacg cgatccactt caaatattgt tcaccaaatg 2015881 cgaccgcatc aggctcactg ataaataacc ttatgaggta tttaccaaat acccaaatca 2015941 taaccgcaat caccagcatg caggaaataa cagctatcac acctagcctt gcaattgttc 2016001 ccactctttt ttcgtttccg attccaatat tttgccctgc catactattg acggccgtac 2016061 cggcagccat tgctggaagc gtgatgatgc tatcaagccg ctgcaccgcg ccaaagcctg 2016121 ataccacgtg atccccgtat gagttaacaa cactcataat cgccatcata ccgcctgtaa 2016181 tcaccatcat ctgcagacct gccggaatcc cgagtttcaa aatcagcgcg gactcttccc 2016241 acttgggcat tctcggaatc gagaatggca caagcttgtg tttgatgaca taaaacaacc 2016301 catacaaaaa cgcaatgccc tgtgacaaaa tcgttgaata agccgctccc gctattccca 2016361 tgcggaacac agaaataaag agcggcgcaa gcactgtatt cagtacaaca gcaaacgcaa 2016421 taaaccggag aggtgtcttg ctgtcgccca gcgcacgaag cacagtactg ataaagttat 2016481 aaccaaacaa aaataaaatg ccgataaatt gaatctgtaa atacgtctca gcaagcggta 2016541 tcattgactc cggcgttttt agaagacgca gcaaaagctc tgagagaaaa aaaccggccg 2016601 cgccgaatcc gatgcttagg cctgttaata aaacaacaaa agcgttaata tacgacgcca 2016661 ttccttttat atcatctttt cctttttgct gagataaaat ggttaacgtc gcattgttaa 2016721 ggcccaaaat aaaagacagc acggtcaaaa caatcgtgct tgataccgcg gctgccccaa 2016781 gggcctttgc ccccagtaaa ttgccgatcc acaagctgtc tataaattga aaggaaacct 2016841 gcaatgcgtt tccgagcata ataggcattg aaaacagtac aagctgtttc agcacgttcc 2016901 cctgtgtaaa atcgtatgct ttcatctttt ctccttgtgt tctcaaattt tcttcggacc 2016961 acacgaaaaa agagacgttg tttcatgtct cttttttcat gacttatcgg ttttttttcg 2017021 gtctcgcata ccgaatgtaa acaccatcac acttaggaac aaggcacaat aggaaacatt 2017081 caaatacatt tgatccatat cttcagcagc cagatgatga taagcaagcc agccgaagta 2017141 cagggaaaat gtaaaggata ataaactgaa atactggtaa atccgtttca ttttcagtca 2017201 cctctattgt ttaggatggt aataggaaaa ctcaatttca tctttttcta aatttatctt 2017261 atccgctttg acatacattc cattcgttaa aggcatttct gacaaacgca cttcaatgct 2017321 tttatctccg gggtgaacat ggacaaatga cggcaattca taaaagctgt ccatataatt 2017381 taacacaaag ctaattggta tactcaattt ccctaacgaa aatttcgtga cattcagctc 2017441 tacatcaccg ttttttttca cggtcggctc aaaagcgata aacgcatcaa tagacgtgga 2017501 aaatgccttg attttccctg cgacatgaac atcatcatca atctctactt tataatcaag 2017561 cttgtttgat gctttgtcgt ttaaatatga gttaacaaac gcagctaatg attcttttgt 2017621 gcttgtcact tgaaatccat actcgctctc agatgcatct ttcacctgag cctgttcccc 2017681 cggaagcaaa acaagtgcca caaacccggc ggcgaggata aaattgattg caagcaatat 2017741 aaaaaacagt cgcttccact tattcatgct gtcaccctac tctttcggta atccttcttt 2017801 tttaatggct tgatagacgc gctttgcgat aagagaataa cccgtaccat taggatgaaa 2017861 atcatcttcc tcagaaattc ggctgctgtc acttttttga ttaaacaaat cttcgatatg 2017921 gacgattttt gcatgtttat cttttttcag ctctttttca gcaatatggt tccaatccgt 2017981 gacgacacca tttatttcat ttagttctga taatgtaaac gtaaacggat tgtacatgct 2018041 gacataaatc agctcagcgt gatcattcag ctcgcgaatt tcagaaatga ttttttcaaa 2018101 gcgcttttcg tacggttttt ccgcttcctg aaacggttca acggttaatt gcagaaagtt 2018161 ttggcgaagg attttcatca aatcattacc gccaattgta aaaaagacat aatctgcgtc 2018221 ctttatgcct ttttgaacct ttttatcttt tagtttttct aataaatcat ccgaacggtt 2018281 cccttttaca gcataatttt tcacgtcgac cgttttgact tgtttatctg accggataga 2018341 atccgccacc ttgccgacat atccctttcc gtcgggatct ccgactcctt ctgtcagcga 2018401 atctccgaca gccgctatga caatgtgttc ttttgttttc gtttcatggg ctttttgttt 2018461 tccctcagat gatgtacgta tgctcgtaca cgcagtaaga agcaaaatca aactggccat 2018521 gattgaaaaa atgcgcagct tcaatcttgt tgctccttcc cattctacta gtggaaagtg 2018581 tatcatgttt tagaagattt gcaaatgcct agtctcttag cttacttgag tgtactggct 2018641 gacttcacat cggaaatgat atcatcgtac ggtgtattct ccactccatt gtaatctttc 2018701 agcaccttac cgtccggacc taccaaataa aaagaagatt gatgaatcac ttggtcctct 2018761 ccctccggct tctttacgat cgctttaaag ctcttaagtg cgaactcctc aatctcactc 2018821 tggctgtatc ccgtgagaaa atcccagtta tcaaaagata atggataatt tgcggcaaat 2018881 ttcttcagct gtttcggctt atcgttttct ggatcaacac taaatgatat gatgcggaca 2018941 tctatatttt cggctttcag ttttttttgc agatcggtca tatgagcggt cattggcgga 2019001 catatagttt cacaattggt aaaaataaaa tccgccagcc atacttctcc ttttaaactc 2019061 tctaaagaaa cgttcttgcc gtcttggttt tgaaatgtaa aaggctccac ctcgtaattg 2019121 agcggatctt taatctgctg tcctccgcat gcacacaaaa acagaaaaat cagcccagcc 2019181 gttaacccct tgataacctt catgacatcc atcctttcca gccagcataa aaacgctttc 2019241 taaaaccgtc cttactgtcc catgtttgta ttcgatactg agcaaaaaaa atcctgcatg 2019301 cctccccatt aacgattaca aaggagggca tgcaggtaaa aaacggcatg ttacgcgttg 2019361 tgctttaaca cctcttgatg aaatacagcc tgataatctg cccacttcat ccgccgcttc 2019421 atataatgtc ggaaagaata cacttttgcc ctgctgtttg atgaaaacac ttcttttaag 2019481 tagaattgca aatggtgatg taacataaag aaatagtgct catcttcctt taatacaggt 2019541 atttctgtca ctttcacctg aatcccgtca ccgcgtttga actctaggct tttgagtaac 2019601 aagctatcaa tcctcttttt tgtttttctt ctattatata tgatgccagc cgggctgtct 2019661 gtcattttgc gcggttgtgt aaaaaaatta gattagcaaa tggaacaagt cctcatcctt 2019721 gttcacctct acataatgaa acggtttttt gttcatccgt tcaatcagcg gcccataatc 2019781 ggctttgttc tgcagctcga tgccgacaag agcaggtcca ttgcttttat tatttttctt 2019841 cgtatattca aaccttgtaa tgtcatcatt cggcccgagg acttcgtcaa gaaattcgcg 2019901 gagcgccccc gctctttgtg gaaaattgac gataaaataa tgctgaaggc cttcaaaaat 2019961 caaggaacgc tccttcattt cctgcattct tccgatatcg ttattgcccc cgcttaccac 2020021 acacaccacg tttttccctt taatttgatc cttgtacaaa tcaagcgctg cgacagaaag 2020081 agctccagcc ggttcagcaa caaccgcaca ttcgttatat aattcaagaa tggatgtaca 2020141 tacttttcct tcaggcacaa ggagaatgtc atcaacgaca gtttccagcg tccggaaggt 2020201 ttcctcgcca atttttttaa cagccgcccc atctacaaac ttatcaattt tatcaagtgt 2020261 gacgacatgc ccagctttgt ttgattcaaa gtaggatgcc gctcccgccg gctcaacagc 2020321 aattaccttt gtatcaggag acacgttttt caaatatgta cctaccccag agagaaggcc 2020381 gccgcctccg acacttgcaa aaagaaaatg cggttctgta tcaatgtcgt ttaaaatctc 2020441 gactgcgagc gttccctgtc cggccatcac atccggatca tcgaacggat ggataaacgt 2020501 ccgagattcc gcctcacagc attcagcagc gcttttatac gcgtcgtcaa acgtatcgcc 2020561 tgtcaaaata atatcgataa atccttttcc gaatagttca acttgagata ctttttgtct 2020621 cggtgtagta gacggcataa aaattttccc gtgaatgcca agatgtttac acgaaaatgc 2020681 cacaccttga gcgtggtttc cggcacttgc acacacaact ccgttctctg tctgctcgct 2020741 ggaaagctgt ttcattttat gataagcccc tctgagctta aaagatctga caacttgcaa 2020801 gtcttcgcgt tttaaataga tattgcattc atatctctca gaaagtctgt cattcctctg 2020861 caaaggtgtg tgaatgacaa cgtcctttac gttttggtga gccttcaaaa tgtctttcac 2020921 ttggatgaga gagttttctt taagcaacgg tttcatgtac agattccttt cttgttttaa 2020981 atccctattt aatatgccat tataacatga atattcaaaa aataagacaa ttatttttat 2021041 ttaataatta aaaaaataca gactatgtcc accacatctt gtggtaactt ctgttcaacc 2021101 attatcctgc agagccaaga aaaaagatga tcgtaaaata aagggtgttt tcaaccaaaa 2021161 ggcatgatat aatgaaacca attagaacca aaaggagcca attgatgaat agtgcaccaa 2021221 aactcaatac atttcaacat ctaatcggag aacatcaaac ttttctggaa gcgaagcgaa 2021281 tcgccaagca gttctcgtta tcggagcttc ctgtcttaat aacaggaaaa atcggaacag 2021341 gcaaaaatca cttcgcacat gccatacact tggaatcttc gagaagcaat gaaccgttta 2021401 taagcgtcaa ttgcagcacc cattcggaag aaacccttat tcatgagctt tttggcccta 2021461 acggaaacac aggtgttttt caaaaagcgg tacgaggaac cctttttctt gatgatgtat 2021521 ggcgcatgcc tgcttctgta caagctcagc tgttaaaagc gcttgattca gacacggaga 2021581 aaccgcgaat gatctgtgct tctgcagacc gatccgtgga acatacattc aggcaagact 2021641 tattctacag actgaacatt ttaacgctca cactgcccga attatcggaa cgaaaaagcg 2021701 atattccgct tttgacacag cattttctct caaattctgg tcagcaattg ttaatcgatc 2021761 cctccgtttt tcccgtgctt gagaagcatg catttgaagg caatgtcagg gaattaaaaa 2021821 acgctgcaga ttatatggcg gcagtatcaa gcgggggaac gattcagcca tatgacctgc 2021881 cgccgtatat tagaggcacg atagacggaa aaacgtcgaa gaaaaaagcg aaactgctta 2021941 ctttaatgga aaaagctgag tttttgttta ttttggaaac aataaaagta ttgaacgaaa 2022001 aaggagaacc tgccagcaga cggatcattt ctgaacacag caaaaatacc caaacctcgt 2022061 taactcctca gcaggtcaga agccgtctcg actatttgga gaaaaaagat tatgtcacca 2022121 aaagccgcgg acgcgcaggc acaaaaatta cctttgaggg cttgagcttt atagagacgt 2022181 taaaaaatca aatgatctag cgatcgaaag gagaatgtac ttgtttacaa tcaaagaaga 2022241 gatcgccaat gcgattacac acggcatcgg tgtcctctta tccatcccag cattagtgtt 2022301 tctaatcata tttgcggcta attacgggtc tgcatgggac attgtcagct ttacaatatt 2022361 cggtgtctct atgctgctgt tatatttgag ctccaccctg cttcacagca tcacacataa 2022421 aaaaacgaag gacattttgg agattattga tcatagcgca atttacgtac tcatcgccgg 2022481 aacctacacg ccttttttgc ttgggccgct gaaaggcaca ctcggcttta ccctgttggt 2022541 tatcgtatgg tcacttgccc taggcggaat cgtttttaaa attttctttg tgaaacggtt 2022601 tatcctattg tcaaccttcg tgtatttagt catggggtgg ctgatgatta ttgcagttaa 2022661 acctttatat gcttcactga gcggagcggg attcagcctc ctttttctcg gcggcatttt 2022721 atactctgtc ggaaccatct tttacatttg gaaaaagatc cccttccatc acgccatttg 2022781 gcacagcttt gtattgggcg ggagcgctgc catgtttttc tgcgtgctct tctattgtgt 2022841 aaaggtgcct ttcctttcgt aacagtaaca gaaaagcgca gtcttcacga ctgcgctttt 2022901 ttatgcacgt aattgttttt cattggcagg tatataagct tttgaaaagg acaattcaat 2022961 gtctgccggt tttaagcgtt taaaaaacga gccattttgc atgttatctg ttcctttcgt 2023021 ttccaccatc accaacggaa gatgatagcg ggccgcaagt tctacaggat caatagaacc 2023081 atctagtgaa agaatcaggc tttgtccctt ttccagctgt tttgtcacat cttcatatac 2023141 cttttctgaa tccccgtctg aaatcacatc catccgatcc agccattgcc cgataaaagg 2023201 caagcggaac acttttgggt tagcgataaa gccggccggt tcctcaatat atccagcaat 2023261 taaggccagt tcagccaaac gcaaacgggg atgcacatac aaaacaggac cgtgtggtat 2023321 tggctctggc tgatggatcg tcacaactga accggagatg ccgatacagc cttctaaaaa 2023381 cgcctttggc tgttcgtaca caagagccat ctgttttttg tatgacagac ggggatcgag 2023441 cattgtttga ttaaataatt gtttcatatt ttttaacagc atatacacaa tataaaccac 2023501 tagaaggctg tagcgaacca attaaaatcc tcccgcttta gaagaattct ttttttcata 2023561 cattagaaat tcgtaatcat acgggttttt ttcgtctttg gtcccctgct cagaagaaac 2023621 cagcttccaa ttggattcat caaattcagg aaagtgacgg tcaccctcaa actcgtgatg 2023681 aattttcgtc atatacagtc tgtccgcata agggaacagg tccgtataga gctgagcccc 2023741 tccgatcaca aagcattctt cagggcctga acaaatgtcc agtacatcct ttaatgaact 2023801 gacaaccgtg catccctgaa attctgaatc cggcgctgag gtaacgacaa tatttttccg 2023861 atttggaagc ggacgtccga tcgattcaaa tgttttccgg cccataatga ttgaatggcc 2023921 cgatgttatt ttcttaaagt atgcaagatc attgggcaaa tgccacggca aatcattgtc 2023981 tttgccgata agcctgttgg catccatcgc aaaaatgaat gaaatcatac gctgaccgcc 2024041 ccttttatat gaggatgcgg atcataatcc tcgatgataa agtcctcaaa tgcaaagtta 2024101 aaaatagaat caacctttct ggcgaaacga agctgcggaa gcggtctaac atctctttcc 2024161 agctgcaaat tgacttgttc aatatgattt tggtaaatat gaacatcacc aaacgtatgg 2024221 atgaactcgc ccggttcaag cccagtcaca tgagcaatga tcatggttag gagggcataa 2024281 gatgcaatat taaacggcac acctaagaaa acatcggcag agcgctgata cagctgacag 2024341 gacagcttgc cgtcagacac atagaattgg aacaggcaat ggcacggcgg caacgccatt 2024401 ttatcaattt caccaacatt ccaggcgctg acgattaagc gtctggagtt cggatttgtt 2024461 ttaatatctt caataagacg ggaaatttga tcaatggttt ctccatcagc tccccgccaa 2024521 gaacgccatt gggagccata tacaggtcca agttcaccgt tttcatcagc ccactcattc 2024581 cagattcgca ctccgttttc ctgcagatag cgtacattcg tatctccttt taagaaccac 2024641 agcagttcat gcgcaattga tttaaagtgg agttttttag tggtgagcat cggaaagcct 2024701 tcccgtaaat taaatctcat ttgatatccg aaagtgctga ttgttccggt cccagtccgg 2024761 tctccctttt tctcaccatg ctctaaaaca tgtctgcaga aatccttata ctgtttcatt 2024821 tttttcatcc tttaaaagta gtcttctagt agtgtaacac aataaaaaat catttctgaa 2024881 cccagaaatg atttttttat agtcagctga cgacaggctt ttcatcctgt tctttttctt 2024941 catcttgcag atcctgatgc gtatgtgcaa ttctgctcgc cgctgctgca gcaagagctg 2025001 ccacaatatc atccaaaaag gtgtgaatac cgtctggact ttcatcaagt tccttaataa 2025061 ttccaatctt ctctttatcc aaataaccga aattggtcaa accgatcgac ccgtacacat 2025121 taacgattga aagcgggata atttcatcta tgccgtaaag cggttcatcc gtttcaacaa 2025181 ggtgctgcag cggttcgggg agaagtttct gttctgcaag ctgatcgagt gcaaggcctg 2025241 tcaaaacagc atgaataatt tcacgtttgt tcaggacttt ttctacattc tccatgcaaa 2025301 cactgagcgg cagatttgga ttgtattttt cctgaagttt ttgaacaatc cgtgcaatat 2025361 cttctatcat aacgccccgt ttgttcagca tatcctttgt tatatcgacc atttcattca 2025421 ttgtgtactt tttcatgtct aatggcatct cctttaggca ctcatccagt tgggaggcgt 2025481 gttgcggtcc cagtaaatgc tcccaagctc atgatgtgat tgaaatccat cttctgctgt 2025541 atgataatga aaattaaacc agtagccgtc atgaggcggg tggtctcttc gcacatggaa 2025601 tctgagaaga tcttctccag ttgtccgatt gtaaacgttg aaaatttttt ccgttttgcc 2025661 cgctgaaggc atgcttgaga tcacaacatc ttggtacgcc tcatcatctt gcaatgtcgc 2025721 taaataatca ctaatcacat tttcgatttt tggcaggatc tctttccgat agtcatcctc 2025781 aatgacagga gcgattctgc tgccgaattt taaaaaggac tgatcctcag cgctgtcaag 2025841 gagctgttcc ttgtacgatt gaaaaagcag ttcaggatct cgcctgtcat ccgactcatc 2025901 atcgtacagg tcatgctcat cataaaaagc ggtgtaatca ttctgctcaa gactgctcgg 2025961 ctgtccggaa ggcttgtccg ccataagggc agccggagga gatacgagcc cgaacgttac 2026021 aatggtaaat aaaaccacaa gggtctttct catccacaat ttcatgactg cttattcctc 2026081 tctattttat tgtcatgttt ctcttatttt agcacatcca aaacatgcaa gtcatgtact 2026141 atatgaaact gatatgcaaa ttaggagatt cgttgctatg cactttgtgt aaaaacgctt 2026201 acaatatttc atgaaaggag gctttccgca tgattgacgc tctgtttgcc acagtttcac 2026261 tcttaacatt attatacttt gtcgtcatgg aggtcaccga ttaacagaaa gcccgtgata 2026321 tgaatcacgg gcttgtttga atgacgccat aatggaacag tgctgttttt cttttcatga 2026381 cgttaaaacc aaactgttca aaccgcgggc ttttccagtg gtcttttagc acaacgcttt 2026441 ttctggcgac tcgtaccgct tcattgatac atccttcgtg caaaacggaa tcctctgcca 2026501 aatcacgtaa aggcgcgatg ccgtcagagg tttctacagg ttcatgaaac attggatcga 2026561 aataaaccac atcaacagag ttgtcaggga gctgcttgat gtgttcaaag caatcaccat 2026621 tcttcacctg gattcttctc atcgcagctt gaagctcttc tatacccgtt tcccatgaat 2026681 gcagccccgt cctcactaaa acagacacaa gatggttttt ttcaatccca acaacagaac 2026741 ccgtttcgcc tactgccata cttgcgataa tggcatctga ccccaacccg agtgtgcaat 2026801 ctaaaaacgt atccccttca gataagccgg cagcccgaag cataggttct ttctccccct 2026861 gtaagaagcg tttggctctg aacatcgctg tattcggatg aaaaaagaat ttggcacctt 2026921 gtttcgtata cagctcaaac cgctctttgc cgaccacaag caaatcacgt tcagctgatt 2026981 tcagcaggtg ctcaaccgtt tgtttattcc ggccgcagta tggcatattt agctctttag 2027041 aaagctgctt tgcagttttt atggtgtgtt cagacggtct atagcttgtt gttatcatct 2027101 tctgtactcc caaaaagaaa atgcccggag aacgggcatt tagcagtgcg catcgaaggc 2027161 agcagtcaga tttttcatga tttcttccat atcgtgtcct tcaatttcat gacgcggaat 2027221 aaaatgtacg acttctttgc ctttcaaaag agccattgat ggtgaagaag gctcctggcc 2027281 agtaaaatac tcacgcattt tcgcagtagc ttctttatct tggcccgcaa atacagtcac 2027341 cgtattgtca ggtgttttgt cattctggag gactgcctgt gtagccgcag gacgcgcaag 2027401 gcctgccgcg cagccgcata cagagttaac gactacaaga gttgtgccct ctgccttttc 2027461 cataaagttt tctacttctt ccgctgttgt taactcttca aaacctgctc cagtcagctc 2027521 gcggcgcatc ggtacgacaa gctggcgcat gtattcttca taagccattg acataaaaaa 2027581 agccccctct agtatccttc atctgaagta aaggatacta tagagagggc cggatttcaa 2027641 atgttcacgc cttaaaataa aagaaagtgt ccccagctat ctagattttc ataataccgc 2027701 cggtgttggc acttgtcaca agtttagaat aacgtgccag gtagccggtt ttcactttcg 2027761 gttcaaaacc tttccagttc gcttttcgtt tttcccactc ttcttctggc acttgtacat 2027821 ccaagatgcg tttttcaata tcaacgataa tatggtctcc gttttcaaca aaggcaagcg 2027881 gcccgccctc agcggcctca ggtgatacgt ggccgattga gaggccacgg gaggctccgg 2027941 aaaaacgtcc gtccgtaatc aatgccactt ttggcccgag tcccattcca acgatttggg 2028001 atgttggcgc cagcatttcc ggcatgccag gtccgccttt tggcccttcg tatctgatga 2028061 tgacaacgtc gccttctttt acttttcggt tgataatgcc gtcaagcgcc tcgtcctgag 2028121 aatcgaatac gacagccggc ccttcgtgtc ttgtaatccc attctgtacg ccgcctgttt 2028181 taatgatagc gccgtccgga gctagattac cgaataaaac agcaaggcct cccttttcag 2028241 tgaatggttg atccagcggg tgaatgacgt cataatcctt tacttcatgt ccggcaatgg 2028301 tttctccaag agtttttcct gtaacagtca gcgcatctaa atgaagcgct ccttctttct 2028361 tcgaaagctc attcagagcc gctgaaacgc cgcccgcttc gtgaagatct tcaataaaca 2028421 catccgatgc aggcgccagc ttagccaagt gcggcacgcg ctcagcgact tcgttaatgc 2028481 gttctaaaga gtattcaacg ccggcttcgt ttgcaagggc aagggtatga agaacggtat 2028541 ttgtagaacc tccgagcgcc atatcgagtg caaacgcgtt atcaatcgct tttactgtaa 2028601 caatatcacg cggtttgata tctttgcgaa tcgtttccat taattgcgca gccgattttc 2028661 tcacaaactc tttgcgttcc ggagatgttg ccagaatggt tccattaccc ggcaaagcaa 2028721 gaccaagtgc ttctgacaga cagttcattg agttcgccgt aaacatgcct gagcaagacc 2028781 cgcacgttgg gcatccgaac tgctctagtt cttgaagctc gttttcgttg attttccctg 2028841 cttggtaggc gcctacccct tcgaatactg aggaaaggga gatttttcgc ccgtcacttg 2028901 ttcttcctgc cgccatcggt ccgccgctga caaaaatcgt cggaatgttg atgcgcattg 2028961 ccgccataag cattcccggt gtgattttgt cgcagttcgg aatacagacc attccgtcaa 2029021 accagtgtgc ggatacaacc gtttccacag agtctgcgat aatttcacgg cttggcagcg 2029081 aatatctcat accgatatgc cccattgcga tgccatcatc taccccaatg gtattaaatt 2029141 caaacggaac gccccctgct tctctgattg cttcttttac gattttccca aactcctgca 2029201 agtgaacatg accgggaacg atatcaatgt atgaattaca caccgcaata aacggcttgc 2029261 cgaaatcctc ttcttttacc cctgctgcac gaagcaaact gcggtgcgga gctctatcga 2029321 ttccttgtgt gatcatatta ctgcgtaatt ctgccatggt gatcctccta aattctttca 2029381 attgtttgat tggattttat tttgacaatt ttcagtttat ttatgggctg tttttgcaaa 2029441 taagataaat acaggccgcc ctcaccttgt tttgttcttt cgtgttttta tatttatata 2029501 gctttctttc gatttgaacc ctccaactat taatattgtt acttactata aatagttttc 2029561 ggatattttt caacaatatt cgaaataatt tttataaaaa gtgaattcac ataaaaaagg 2029621 tgcatgatct gcaccttttt tatctttatt cgcctttttt tctgctttcc gtcatttgtt 2029681 tccaaacaga accttttgct tcttctccat gctcaatacg ttcaagcgcc attttgactt 2029741 gaaggctgac ctcaaattcg gggtcatctt cggcagcgcg caaagcttca attgcacttt 2029801 catcgccgac ttcgtacagg aacatggcgg cacgccagcg aacaagcttg ctggagtcgc 2029861 ttaatgactt gatcatagca ggaatggctt gaggatcgcc gatatcagac aggcagtctc 2029921 cggccgttct tctgactgat acagctttgt cctcaagtgc tttatacaat agaggaagaa 2029981 catcaggtgt ttcaatcatt cctaagtaca caacagcctg tcttctgatg gacacctttg 2030041 gatcatccaa tgccttctgt aaaaccggga tatcctcttc tttcggatcc atctgttcca 2030101 agtgtgcata acgctttttc cagtcctcat catccagcat atcaagcgtt actttatacg 2030161 ctttgcgctg tacagcttgt tttgcttcgc cctttccttg agcggctgct tcagtcagtc 2030221 gtttcagccg ttcatcactg tatgccgctt gaagctcttc tgtcacatca tggccgattt 2030281 catcaaagtc accgaatctg acaccttgtt ctttccaagc ccgctcaaac acaacattgg 2030341 aagcttcaga tctaagtttt aagatcgcct gctgaaagcg ttcaggtaag ccgaagcgtt 2030401 cttcccgctc tccatcggtt aatttaactt gcataggaat gccgctgaac atctgcacaa 2030461 aaacttttac ctctccaaaa gattcttgat cagaacgatt ttcttctgcg ctttcagcac 2030521 tttccatccc aaatgcagtg cggacttgcg gtaaaatgtc tttccagtcg tatcttgcat 2030581 tccgttcaac agcaagaaaa tctgcgacgt gatatacccc tttaactcca tctattttaa 2030641 ggatttccgc tataacaagc ggtgcgcctt ctgcttgctc aggtttatag ttattgcttt 2030701 tgcccgccgg aagctcttcc gttaagatga ctttcattgt attcgggctt ggtgtaggtt 2030761 caattgattt tatcttcatg atcgtcctcc tatagcatat ctgtgactta ttctatcata 2030821 gtcgctccaa gccttctatt acgacgtttc ggcatcaatc ccgggtatgt ctttttctaa 2030881 ttggcggaca aattgaagca taaaattgtg tctttcttct gccagttccc gtgcagtgtc 2030941 tgtattcatc atatctttca gccgcagcag cttatgaaaa aaatgagcgt aggcgctttg 2031001 ctcatctcca taaaggccat gcccttttgc gcccgcaaac atgaaagctc tcgcaatgcc 2031061 gacagcacca atcgcatcaa gtctgtcagc atcctgtaca gcttttcctt caattgagag 2031121 cggctccttc gccaatttcc ccctgtcccg aaaggacatc cttgttataa tatgaatcac 2031181 cctgtcagca ttctcttttc ctactccgaa aaaaacgagc tgatcatata cttcgctcac 2031241 agaaagcctg accgtgtcag gcagcttcac atcaattaaa tcatgaacca aagccgccgt 2031301 ttcaacaatg aacaaatccg ctttttcctt ttctccaata tacgctgcaa gatctgctac 2031361 tcttgataca tgatgccagt catgtccaga gctttcgtca gtcaggatag attgaaccca 2031421 tgtcctgatt tgctctgcct gcttcaattc cttcacaaaa acaccctctt tttattgctc 2031481 taatagcttc acgatatcgt cttccaactc tttcggattt gtatttggtg aataacggcc 2031541 aacgatttct ccatttctat ccactataaa tttcgtgaaa ttccacttga tcgccttagt 2031601 tcccagcatc cctttcgcat gttctgtcaa atacacaaac agcgggtggg cgtttttccc 2031661 gtttacatcc acttttgaaa acataggaaa tgtaacaccg taatttgttt cacaaaattc 2031721 ctgtatgtca gcctcttcac caggctcttg gttcatgaat tgattgcagg ggaaccctaa 2031781 gatctccagc ccctcctgct gatatgtatc atataattcc tgcagctgct tcaattggga 2031841 agtaaaaccg cacttacttg ctgtattcac gatcatcagt acctttcccg cgaaaggctg 2031901 aagtgtcatg tctttccctg tgattgtacg taccttcata tgataaatag acatgtaagt 2031961 ccctcctatg tccttggtgc tgattatttt acctttttta aatcgcaatt caaaatgtaa 2032021 acatcaatta agaactcata agaaacctaa cgatatgagc gtcagttcat tatcaattca 2032081 tatggctcgt tttttatctt atcattctat aaaacattac aattccctct tacatctttg 2032141 aaaatcattt tactgtgaaa ccaaaaggcg tgtcagtgcg ttttatttaa agagttttct 2032201 gttgtttccc cctcaacacg tatagataga ttgaaaattg gcgtgaaaat tcctataatg 2032261 aagaaaatta aacggggaaa taatggaggt ggcacgttgc ctattaatat accaacacac 2032321 ctgccggcaa aacaggtgct tgaaagtgaa catatatttg taatggatga aagcagagca 2032381 tttcatcagg atatccggcc gcaaaaaatt attatattaa atttgatgcc gaaaaaaatc 2032441 caaacagaga ctcagcttct cagattgctt ggaaattcgc ctttacaggt tcatttcaca 2032501 tttttaatcc caagcacaca cacgccgaaa aatactgcga gagaacacct tgacgaattt 2032561 tacacgactt tttccaatat ccgtcacaag aggtttgacg gcatgattat caccggtgcg 2032621 ccgatcgagc atttggcgtt tgaagaggtt tcatattggg aagagctcaa ggaaatcatg 2032681 gagtggagca aaacaaatgt cacttcaacc ttgcatattt gctggggtgc tcaagcaggt 2032741 ttgtattacc attacggtgt ggaaaaaatt caaatgccga aaaaaatctt cggtgtgttc 2032801 gaacataccg ttctttcaaa acacgaaaga ttggtaagag gttttgacga gctatactac 2032861 gtgccgcatt cccggcatac agatataaat atggaacagc ttcaagcagt gcccgagtta 2032921 aacattctta ccgcatcaaa ggaagccggg gtttgcttaa ttgtgtctaa agacgaaaaa 2032981 caagtctttt tgacagggca ccctgaatat gatacaaata cgcttcttca agagtatgaa 2033041 agagatttgg aacgaaacct ttctactgtc gaggccccta aacattattt tgcaaaaggc 2033101 agcaacgagc cagtgaatcg ctggaaagcg catgccacat tattgtttat gaattggctg 2033161 aattattacg tttaccaaga aactccttat gaatgggact aatttttctt tttttagtga 2033221 tacgctgagc aaaaaatatg ataaaataca tctgattcag tctgcgtata acaaaaattt 2033281 aaaatactgg aatccaaatc atttaaaatt agcttaactt tttcactgca ttaataattc 2033341 gattatgtat ttgtgttatg tttatgtata gacaataact ccttacgatg catgaagctt 2033401 gcttgttgtt gattacattg aggtgaattt acttgaatac caataaaaga gtattaattt 2033461 tgactgcaaa ttacggaaat ggacatgtgc aggtagccaa aacactttat gaacaatgtg 2033521 tacggctcgg ctttcagcat gtaacagttt ctaatttgta ccaagagtca aatccgattg 2033581 tttcagaggt aactcaatac ctttatttaa aaagcttctc aatcgggaaa cagttttatc 2033641 gtttgtttta ttacggagtt gacaaaatct ataataaacg taaattcaat atttacttta 2033701 aaatgggtaa taaaagattg ggcgaacttg tcgatgaaca tcagcccgat attattatta 2033761 atacatttcc gatgatcgtc gtgccggaat acagacgccg aactggaaga gtcattccta 2033821 ccttcaacgt tatgactgat ttttgtcttc ataaaatttg ggttcacgaa aacgtggata 2033881 aatattatgt ggcgacagat tacgtgaagg aaaaactgct ggagatcggc actcatccaa 2033941 gcaatgtaaa aatcacagga attccaatca ggccgcaatt tgaagaatcc atgcctgttg 2034001 gcccgatata taaaaagtac aatctttcac caaacaaaaa agtgcttctg atcatggcag 2034061 gtgctcacgg tgtattaaag aacgtaaaag agctgtgcga aaaccttgtc aaggatgacc 2034121 aagtgcaagt agttgtcgtg tgcgggaaaa atacggcttt aaaagaatct ttgagtgcgc 2034181 ttgaagcgga aaatggtgac aaattaaaag ttctgggcta tgtggagcgc attgatgagc 2034241 tatttcggat cacagattgc atgattacca agcccggcgg cattactttg acagaagcca 2034301 cagccattgg agtgcctgtc attctgtaca aacccgtgcc tggccaggaa aaagaaaatg 2034361 caaacttctt tgaagaccgc ggagctgcca tcgttgtgaa ccgtcatgaa gagattctcg 2034421 agtcagtcac ttcccttctt gcagatgaag ataccttgca tcgcatgaag aaaaacatta 2034481 aggaccttca tttagcaaac tcctctgaag tgattttaga ggatatcctg aaggaatcag 2034541 aaatgatgac cgccaaacaa aaagccaaag tgctatcgta atggcgtact tgagagcata 2034601 cgaaaatcgt gtgctctttt tatttatatt cagccatcaa taaaagcggt tacatttttt 2034661 tatggaactt gcccttcttt tgaaaaataa gccgtttcgc aacttgacgg gtgctcccag 2034721 atggtgtata gttgaaccat catttaacaa tgaatcaaag ttagatgatg acaaaatttt 2034781 ttttagcaca tgggtgctac agtactagga ggaattaagc aatatgcaaa acggtaaagt 2034841 aaaatggttc aacaacgaaa aaggattcgg cttcattgaa gttgaaggcg gagacgatgt 2034901 atttgttcac ttcacagcta tcgaaggaga tggatacaaa tcattagaag aaggacaaga 2034961 agtttctttt gaaattgtcg aaggtaatcg tggacctcaa gcttctaatg ttgtaaaact 2035021 ctaaactcaa tacatgatga tgagatgaca aatagaggag aggcattcgc ctctcctatt 2035081 tgattttcat ctggatttca atcgccaaaa tgttttgttt acacctctgt tcaatctctt 2035141 caacatactt ttccattgat ggttttcctt ttttcgcgat atcggccagt tcttctaaat 2035201 cactgtatat ttctataaat gttttgtgaa ggatcaactt caagtcttta tcatccatag 2035261 ctgcgttccc cttctctatc aagatacctc aaatagtaaa acggtcctat ttattctggt 2035321 tcaatagtta tatcggctta tttttatttt cttttctatt ttggtacata aatttcaaaa 2035381 aaactctgca aaataatggc ggaggtgttt tttgtgactt cagaatttca taatgaggat 2035441 cagaccggct ttacggataa gcggcagctg gaactagcgg tggaaacagc gcagaaaaca 2035501 acaggagccg cgacgagagg ccaaagcaaa acattagtcg actctgcata ccaagccatt 2035561 gaggatgcta gagaactgtc acaatctgaa gagctggcag ctctcgatga tcctgaattt 2035621 gtaaagcagc aacagcagct gctagatgac agcgagcatc agctggatga attcaaagaa 2035681 taaaaaccgc agcttctgcg gtttttattt ttagtgattg gttaagacat ctccgtattg 2035741 tttcaacttt tcaccaaccg tacatttatt gatacaaaat gaatgcgcat aagttttgcc 2035801 aaattctttg cgaaactgct tcttaataaa acagtccttg caatattcat cgtgcagttc 2035861 tgtcagttct ttaaagatca ttttcttatc caatatcgtc atctccgtta cggtctaatt 2035921 tcgtgtggct ttctacgaat tgatgggata gaattttttt agcgaggccg tcagcttcct 2035981 gattgtcttt tcgttgtatt gtttcgtagg ttggagtaag cttcagcgat tcaaggagtg 2036041 cttctatttt gtccagccat tcattatgag atggatcata acaaggccag ctgccgtcaa 2036101 gctgattcag cacaacaagc gagtcccctt tgattgtaat tgaatttctg cttgccccaa 2036161 gctctcttac ttctcttatt gcttcataaa gcgctgcgta ttcagcttca ttattggttt 2036221 tcagccggaa gcttttattt tttctcaagc gatgccgggt tcctcccaat gaataataga 2036281 tgacgatccc gagaccggcc agttcgctct ctttatcgaa actgccgtca aaataaacag 2036341 taatgtcatc aggctcttga gcaagctcct ctgtcagctt ttccaattcc ttcagcgtcc 2036401 agctgccgcc tttctcgtct tcgaactcta gctccttcat gtatggaaaa cggccaagtt 2036461 ctctggcgaa cgtacgtgcc tgctgtgctg tcagccagtc ttcgctaaaa aatgagacgg 2036521 atcccgttcc ttttgcttct attttcaaat gcggtctgag cttcattaca atcaccttac 2036581 cattcattag ttgccgggct tatgctataa tcaaaccaat cttaccccgg aaaggaagct 2036641 ttttcatctt gtttaataat tcgttttgga tcttttttgc gatcattcat tttatcattg 2036701 ttcttttatt ttataaagga tttggcaaaa tgggactgtt tgtttggatc ggttttgcga 2036761 cagtctgcgc caacctccaa gtcgtcaaaa cagtcgaact gtttggctta acagcgacac 2036821 tcgggaatgt gatgtatggc acaatctttt ttgcgacaga tgtgctgaat gaaaaatacg 2036881 gaccagctga agccagaaaa gcggtatggc tcggattctc aacgctcctg acgctgacat 2036941 ttgtcatgca gggcgtgctg cttttcgaac cggcttccag cgacatatca caaacagcgc 2037001 tggaaacgat cttcggattc cttccgcgag ttgcgttagg aagtctgctt gcctttatct 2037061 tcagccaaac gctggatgtt tatgtatatt cggcaattag aaggatattt ccttctgatc 2037121 ggcttttatg gctcagaaac ggcggcagta cagcagtcag ccagttgttt gatacattca 2037181 tattcactgc agtcgccttt ctcggcattt atccggcaga cgtgtggctt catattttta 2037241 tttctacata tttgattaag tttgcggtat ctttaatttc attgccttat gcctatgcag 2037301 ccaaaaaaat gatacctaat gatgaaagga gttcataatg cctacagaaa tatatgtaga 2037361 cggcgcaagc gccggtaatc cagggccttc cggtatcggc atttttatca aacatgaggg 2037421 aaaagcagaa tctttctcta ttccaatcgg agtgcataca aaccaggaag cggaatttct 2037481 tgcattaatt gaagggatga agctatgtgc aacgcgcggg tatcaatcag tttcctttcg 2037541 aaccgattca gatattgtgg aacgcgccac tgagcttgaa atggttaaaa atataacgtt 2037601 tcaaccgttt gtagaagaga tcatccgatt aaaagcggca ttccctcttt ttttcatcaa 2037661 atggataccg ggcaagcaaa accaaaaagc cgatcttctg gcaaaagaag cgattcggct 2037721 gaatgaaaag aattaaatct tgatcattgg ttcatcctaa tggcgaggtg aactaacatg 2037781 aaaaagaaag ataaaggccg gctgaccggc ggtgttactc cgcaaggcga cctggaaggc 2037841 aatacacata atgaccctaa aacagagctt gaggagagag caaaaaaaag caatacaaaa 2037901 cgctagagag gatctaaacg atctctctag cgttcagctt ttcaagcata cgctcaattc 2037961 ctttaatttg gtggcggcga agcatgtcag ccgcctgctc catttgcaaa gtaaataaag 2038021 cgtctttcag tgtgcaggcc agcggcactg agcaatggat ttccgcaagc ttcctcgaca 2038081 tctccaaatc gcttaaacct tgctgaattt ttccctgctg tccttttgga agaagagaaa 2038141 gattttccaa taaacggtca atcgtttcgt attcacgaat cagtttgtag gctgtttttt 2038201 ctccaatgcc tttgactccg ggatagttat cactggaatc acccataagc gctttaatat 2038261 caatcaaagc cttcggcatt acgcctgttt cttcataaaa agtctctttt gtatagactt 2038321 tataatttcc gattcctttt tgaagcaaag caacgcttac tttatccgtt aacagctgaa 2038381 gtaaatctct gtcccctgtt accaccgtaa tgtccgcttc attcgcaaat aaatcggcaa 2038441 gagtaccgat acagtcatcc gcttcatagc cggcaaagcc aatattcatg attccaagct 2038501 ctgcggctgc ttcctttgcc aaatcaaact gcggaatcag ctccacaggc ggcgcgctgc 2038561 ggttggcctt ataatcttgg aacaagtcat ttcggtacgt tttgctcccc atgtcccagc 2038621 agcagacgac gtgtgtcggc tggaatgttt ccacagctgt aatcaaatgc tttaaaaagc 2038681 cgttgacgcc gttcgtcggc accccgctgt catttatcat aaagttgcga tgtacggccg 2038741 tggcaaaaaa ggcccggaat aaaagagcca tgccgtcaac cagcaatagt ttattattat 2038801 tcatcaaata actccctttt ctttcattcc ttctatttta tcataaagca gcccaaaaat 2038861 aaaaaacagt atctctttaa ttagagatac tgtttgaata tttatcaatc gttgtgtctt 2038921 ttgttgctgg cgatcagctt ttcagcttcg cgtcctgcgt aagagtcaaa atgggtttga 2038981 aatccgtttt tctttttggc gttgttattc gcctgtgcat ttctgtttcc gagctttgtt 2039041 ctgcccaaca tgaatccccc cttacgtcgg atgcatatag tatatgcttc cggcaggagg 2039101 ttcactcgcg acaggatcat ccagcttaca tgcggcttac gtattctctg accatttctt 2039161 ttgatacaag ccgtcttgtc gggacgatgc cttttttagc gagctgattc atttgctcgg 2039221 taatttcatt aattgcatct gtagtataag gctcatcgtt tctgcattta gcaacagctt 2039281 cttcaatcgc caattcacgc atattttcaa gacgcataaa tgctttgata tgctcgtgct 2039341 gttttgatga atgtgctgaa attgctttat gtacctctga cattaatcgt tcatctcgct 2039401 tttttctatt tagtctatca tgacttgaaa tacaagccaa ctgaatttta catttttatt 2039461 gtattgtctg aatttttcca ggagatgcac gcctgatacg ccatttcaat ctctttcgca 2039521 tgttcccctt ccgcatatcc tcttaaatat gtctcttttt gatccgttat ttgcgcgatt 2039581 gctttttcac ccatatcttc ctgtaagcgt ctgaggtgag cagtgtaatg agatatcagg 2039641 ctttcttctt cattttttat ccatgcctct gtgattttcg taagtttcat ccgtacagct 2039701 tcgataaagg tcgcttttcc tttctgctca aaaaactgct tcggtgattt gatctctttt 2039761 agttcctgct caaaagcacg ttcttctatt tccggttcaa cttccttcaa ctgtatgccg 2039821 ttcgaatgct gatcacccgc ataaacggaa aaataaccgt cctcgtttaa tgttttttga 2039881 aaatgatcca gccattcttc attgatatgc cgttcgatga aaccgctcat gcgaacatca 2039941 agcgttttga tttcctgaat atattcaaat agatattcat gtaaggctgt tgtcatcgct 2040001 ttactgacgt tctttttcca atccccgttt tgcagcccgg gatgaaatgc cgattttaat 2040061 aaatcatttg caaaatatga taatcgctgt gcaatgtgat atagctgctc tcttgtatct 2040121 ttttttactt tttcaatgat ggtttttgag ttccgccgtt tctcgatatc ggccgctgtc 2040181 cgctcaaatg acagcataag gcactgtttc tgcgcttcct tctcttctcg ggactgatgc 2040241 tgggattggt gaagctgaaa aacagtttcg catagtttgt ctgcctccga actgagctgc 2040301 gctgctgacg ctttttttac atccacttcg ataaaccggt ctaagtgttt tcttactttc 2040361 gagaactgat tataaaatga ctccggtttt cccaccagtt cctccttact tgatacggta 2040421 aagagctgcg gctcataaac cccttctttt acaagctctg cgctgacata atcggtcact 2040481 gtttcgagct ctgttttatc ttttgcaagg tctgcagcat taataataaa aaacatttta 2040541 tccatgctga gcgattcttt cacaagtcca agctttcgca aaaatgaacg gtctcctttt 2040601 gaaaaagagt gctgataata agtcatataa aaaaatgcat cagcatcttt gatatattgg 2040661 aatgccagtt ctgtatgccg tttattcatg ctgctcgcgc cgggtgtatc aacgatcgta 2040721 atcccttttt cagtgagcgg gcatgtatag tagaccgtta cctctttcac agcacaggcc 2040781 gttgtttcct ctgctacata cggctttaat tcagagagcg gaatcgttaa tttcttctgt 2040841 tcctgtatat actgctgata cttctcgtat gcaagcagga aattgctgat caatttcacg 2040901 tgttcttcct gcagcctgtt ttttttgact gccttttccc acttctctgt gaaggaacgg 2040961 cctgccggct cctttggtat tccggtgagc tgcaaaattt cagccgttaa gtcatcctct 2041021 gtcttaaaca ctacattcgc tgttttgttt aagttgccat tgattggctt tgtgatcttg 2041081 ttaattgtcg ctgtggttgg cgttggtgag gatggcagca ctctttcgcc gacaagcgca 2041141 ttggcaaatg atgatttccc cgagctaaag cctccaaaaa gagcgagtgt aaatttccgt 2041201 tcctcaagcc ttttcaccct ttcacgaaac gctgaagttt gctttaacaa catgctgcat 2041261 tcgcctaaaa tgtcagacaa agtgtaaaag cgtttgattt ggtcttgaag cggcatttct 2041321 tgttccattt tgatttctga tttcggcatc ggctgcgccg tcagctggct tcggccttgt 2041381 ttctgctctg gagccgccac tcttgttttc ttcgatttaa accattctgt gtctatatgc 2041441 attgggcatg cggactcttc ttcccaaatg gcccacaggc gatcggtttt ctctcgggca 2041501 ttattctcta aacgtgcctg ttcttgaaga aagacaagtt tttctgattc ttggacgagc 2041561 cggtcgttaa ttgtttgcac atctttggaa acacgctctt tcaccatagc ggagagcacc 2041621 tttatgatgt ctgcggcttc tcttttcgcc tctttccgga tgagctctgc caagtctttt 2041681 gtatattgca atacatattc agaggaaaag gctgcaccat gcttgaccgc gtgttcaatg 2041741 atgcttatat caagcggtgt gcgataggcc tgaatcagct tttcactttc agcggtatag 2041801 acatcaaata ccttggcgag tttatgaagc gtgtctatca tatgccaatc cgcttcggcc 2041861 tctgttcgtt ttgccacatc agagaaaaaa gcattccgcc ttttatctct ttcctgtgca 2041921 gttttcgctt tagaaaagaa aaagccggtt ttaaaggaag gctcttgtga ttctaaaaat 2041981 gcagccgcca attcacgcat ttcaaaaggc gtcaggttgg cgttttttaa aatacgattg 2042041 atttcttcct gcatcctctt ctctgcctca gtcatttgtt tttcggcctc atccaattga 2042101 tcacgcagcg attggaccag tccagtatgg atattaagct gttcagcgaa actcggagcg 2042161 cctgtttcgt ctttcttcag catttccgta tgttccttta gcagattacg gactttttgt 2042221 tcggttaaag cctgcatatt gctttttgat tgctgttcta ttctgcttaa ctcttctctc 2042281 agggccccca tctgattgaa cgggtgatcc ggttctgtta ctgatgtaaa atagagcgct 2042341 tcccttgaaa tcccttcatt gcaaagcatc tcctctacct gcgcttgata gtctccaaat 2042401 ttcgtctccg tctcatcatg gcggtcaatt tgattgacga taaaatacac attcggaatg 2042461 ctttctttta ttgatctgag aaactttaca ttttcctcag cgtgcacgtg attatagtga 2042521 acgacgtaaa acagcgcatc cgcttggtga agaatagaag cagccgatag aaaatgcgca 2042581 tcatctgttg aatctatccc tggagtatca atatacgcaa ccccggaatc gatctcagta 2042641 tacctgtcaa aaatttcgac gctttcaatc tgttccccgt ctttacaata ttgctgcacc 2042701 ttgtctttct ggtaagtccc ttccagctca gcacacgctc cgtctgttgt atgaagccga 2042761 actcgctttt ccccgtttct gatcacaaca aggttagcgc ttgtcggaat cgggcttgtc 2042821 ggcaaaatat tctccattaa caggcagttc agcagtgacg atttccccgc tgaataatgc 2042881 ccggtaaacg cgatataaac ctcttcatca gccgcttttt tcatgaccgc agccagttta 2042941 gcagcccttt gttcatcttg attctcaata aattgcttat aaagttcccc ggttttatgc 2043001 aaaagctctt ttctgttttg atctgtcata agtctgaacc cctttgtgcc gtttcaattg 2043061 tgaacctttt tcgaaagatc tgaattcatt cccttttcat tttacacaag aataaaccaa 2043121 atttctttag gagaatagaa aaaagccgcc attacggcag cttctataaa agaaaatctg 2043181 caacttttac aagttccaga ttcatcaaac agatttatta gagattcctt ttaatacaaa 2043241 accaattaat acactatatg tacaaaccgc tccaagcaaa aacagcattg tcatttgctt 2043301 caccatcctg attgagaatc tttttcaaac ccattttaac atggttgaga atgattttca 2043361 atcgctattt tacgctgtat tcctgtaatg ctttgtcttc tgcgcgaatt ctgacgctta 2043421 acaacacggc attgaaaatg gaaaacagac acatggtgac gtatgcttga taaagcagcg 2043481 gaatcagcaa aatttcgagg ataacaacgg catagtttgg atgtttcatc catttatatg 2043541 gacctttttt tacaagctct acacctggaa caacaaggat tttcgtattc caatatgctc 2043601 ctaaggaaca aagcgcccaa taccgtacga tctgtacgct taaaatcact gcagcgatac 2043661 cgagccacca gctggacggc tgtttattca tcagcagcac ctcggcaatt aaggacagga 2043721 aaaaaaggat atgcatcgta atgatatacg gatagtggct ctcgccaaat tcaattgctc 2043781 cttgcttctt taccttttgt tcgttttgcc tggccactgc catttctgct gctctttgaa 2043841 caatgagaat ggcgatcaac aaccaaaaca tgagtcaggc ccccttttcc cagctgaata 2043901 atagcaactc tgatgagaaa cccggcccta atgcgccaat cagtcctcgt tcagcttcct 2043961 ttttatgtcc gttctgcaga tggtctttga tcacatacaa gattgtggct gaagacatat 2044021 ttccgtgctt ttgcaaaatg ctttgcgcag atgaaagctt ttctgacgac agcccgagac 2044081 ttttgatgta tgcatcgatc actttttttc cgcctggatg cgccaaaaaa acactgatat 2044141 catggaatga cagcttatgt ttgtccaaaa aaatctgtac atttgttttg agccattttt 2044201 ccaccaaggt cggaatgtct cgtgagaaaa tgactttgaa tccttgatcg gtaaagtccc 2044261 agcccatgac atcttctgat tgtttcatca aaacagattg ggcgtccatt atcttcggcg 2044321 caagcttcag ctttgacacc ctgcggtccg ccttctctcc gcataataaa gctgcggcaa 2044381 tgccgtcacc aaaaagcgag gtgccgatca gattgctttt tgttttatct tccggctgga 2044441 atgtcaggct gcacagctcg gcagaaatga caagcacaaa agcctcagga tacgctttgc 2044501 agtattcggc tgcacgcgca agtccgctgg ctcctcctgc acagccaagc ccccaaatcg 2044561 gaatccgctt cgtatatgga gaaaacggaa gttcattcat aagccgcgcc tcgatactcg 2044621 gtgtggaaag acctgtactg gagacgaaaa aaacagcttc cactttctca taaggaatgg 2044681 cttcttgaaa aaattccgga tgagagaggc actcacgaac agccgctctg ctgtgtttaa 2044741 gtgtttcttc tatgtatatt tgattttttt cttcaaagct gtgcccctct ttataccatt 2044801 caatcggctt aacaaactgt ctcgaatgga tttgcccgtt tttaaaggag gataacagcc 2044861 tgtcaatatc cttaaaagaa tgctgaaaca tatagcgggc gaactcggcc gctttctctt 2044921 ggtttacatt atacgcagga agacttgttc caatggataa aataaacgcc atgcgatcac 2044981 ctctttgcat acattgtgcc gcaacaatct tttttatatg caaaaaaaac tccgccgcgg 2045041 cggagttaga ctgctgtttt ttgttcagcg aggtcagctt cttgttctat ttttttagct 2045101 ttagaaaaaa cgttatatac aatatttaag acgactgcag taaagctgcc cgccacaatg 2045161 ccattcgttg taagcagcgt taaggcactc ggaagctgtt tgaaaatatc cggcacaacg 2045221 gtcacaccga gccccaatcc cactgagcaa gcaacaatca gcagattttc ctgtttcgca 2045281 aaatcaatgc ggctgagcat tttaattccg taagcaatca ccattccaaa catcgccacc 2045341 attgcaccgc ccaaaacagc ggatggaata atagtcgtga aagcagcgat ctttggaaac 2045401 agcccaaatg ccattaggat cacacctgtg accacaatga cggcattttt tttgatccct 2045461 gtgagctgaa caagcccgac attttgagag aatgccgtgt aaggaaaagc gttaaaaata 2045521 ccgcccagaa gcacagccag tccttcagct cgatagcctt tagacaaatc tatctctgtc 2045581 aaacggcggt ttgtcaggtc acctaaagca aagtaaacac cagttgactc cacaaggctg 2045641 acaattgcaa cgatggacat cgtaatgata ggcgctgcgt gaaaagacgg cgctccgaag 2045701 taaaatggct gaatcatttg aacaactgcc gcgtccgaaa cattatcaaa ttgaactttt 2045761 cccataaaat atgcgatgaa ggtgccaatc aaaataccga tcaaaatcga gacggacttg 2045821 ataaagcctt ttgtaaaacg gtatagaagc acaatgatac tcaacacggt aaaagcaagt 2045881 gcaagattgg agagatctcc gaaatctgca cttccttctc cgccggccat gttattcatg 2045941 gcaaccggca tcagtgtaat accgataatc gtaacaacag agcctgtcac gaccggcgga 2046001 aaaaacgata cgagctttcc aaagaaaaat gaaataagaa tgacaagaat gcctgaagcg 2046061 ataatgctgc cgtaaactgt tgaaacccca tattcagatc caatcgctat catcggcgat 2046121 acagctgtaa aggtacagcc aagcactacc ggaagcccga tcccaaaaaa tcggttgctc 2046181 cacacttgca gaagtgtagc cacaccgcac ataaaaatat caatcgatac taagtaagtc 2046241 agctgctcga cagtcagtcc cattgctttt ccgacaatca gaggaacgac aatggcgccg 2046301 gcatacatgg caagaacatg ctgaatccct aaagacagcg ttttgccgaa tccatttctc 2046361 atgaatgaac ctcctgtacg aaggacactt ttccttcttc taaagactga attcttgcca 2046421 aagattccac tcggtagccc agttttacaa gttcatctct tcccggctga aatgactttt 2046481 caataacaat gccgattccc gcaatagaag ctcccgcttg cttcacaatc gacacaagcc 2046541 cgtgcgctgc ctgtccattt gccaaaaaat catcgataat cagcacatga tcctgatccg 2046601 acaggtgggt cccagacact gcgatttggc tttctgtttg cttcgtaaag gaataaacag 2046661 acgctgtcag caagttgtcg gtgagtgtta acgatttatg ctttctcgcg aagacaactg 2046721 gcacacccag cttcaagccc gtcattacag cgggagcgat acctgatgat tcgattgtca 2046781 caattttggt aataccgtct tttgcaaacc tagacgcaaa ttcatcacca attctctgca 2046841 taagcagcgg atcaatttgg tgattcaaaa aagaatccac tttcaatacc tgatcagata 2046901 atacgacgcc ttcttcctct attttccgtt tcagtgcttc catcctgtct acctccgtta 2046961 tgagaataaa aaaagcattg cccgctcaaa taaagagcaa gcaatgctga tatcacaaaa 2047021 aaccgtacac gtgcggttcc attgctcacc catagtcgga catttacggt gcccggtaga 2047081 aacttgcgtg ccatatccac gcgattatat gagtgttcct attatattgt aataaattat 2047141 atcaagattc taatctcttg cataggctga aaataaaaat tcccgaactt taattttgtt 2047201 tttttagata tcattcgtat ttcaagggga ttcgatataa aagagtctga cgaccgcgcc 2047261 gccaggcttt tgattataac agatagagat ttgaatattt gtttgataaa taatcaatta 2047321 aatagcgaac attcagctct tctcctgttg catctttaat aatgtctaac ggctttttcc 2047381 gttttccgtg aatgtgcacc ttttccgtca gccattgctt tatcggatgg aactctcctc 2047441 tttccaagag agcgtcaaat tcagggagat cctcaagcat tttttgtttc agctgagccg 2047501 catacatgta gccgagcgca taggatggga agtagccgaa atctccacct gcccaatgga 2047561 cgtcctgtaa aatcccctct gcgtcggtct gcggtgtaat ccctaaataa tcctggtatt 2047621 tttgattcca aagcgacggc agatcttcca cagacacttc attgctgaaa atcgcttttt 2047681 caatttcata acggatgatg atatgaagag gatacgtcaa ttcatccgct tcgaccctga 2047741 taaatgaagg ttttgattca ttgattgccc ggacaaaatc atccagggag atgtccttga 2047801 actgtacagg tgatgcctct tgaatcttct tatagtacgg agtccaaaaa tgcttgttgc 2047861 ggccgataaa attctcgtaa aataatgatt gcgattcatg aattcccatc gatgcgccgt 2047921 ctgacaagtt cgtgccactg agtgcttcat caatattttg ctcgtaaatc gcgtgcccgc 2047981 actcatgaat ggtcccaaag atcgccgtcc ggaaatcttt ttcatcatat ctcgtcgtga 2048041 cccgaacgtc tccccgattc agcgtagttg caaacggatg aacggtttca tcaagtcttc 2048101 cgccatcaaa atcgtagcca agctcctgta aaaaatacag actgagctct ttttgctttt 2048161 ctttcgggaa cgcttttgta ataaagcttg tatctggttt atttccggaa gctgtcacct 2048221 gtttaacaag agggataatc gcttccttca gctcagcaaa caactgatca agcaccttta 2048281 ccgtgacgcc gggctcaaac aaatcaagca atgcatcata aggatgctct tgatatcccc 2048341 aatacgtaat aaaacgttta ttgaattcaa tcagctgttc taaataagga gaaaacaagc 2048401 tgaaatcaga ttttcctttc gcttcctccc acgctgtttc tgcctttgaa cacagaatca 2048461 cgtattcttt gtattcagcc tcagggattt tcttattctc ttcatactct tttttcgcca 2048521 gttccactgc ttttttcgta tcttccgaca agtcatcaaa tcgttcatac aggacatcga 2048581 taagctcctt cattcgatct gatgtttgga tattgaatat atctgttgaa agctggccga 2048641 tactttcggc acgatcctct gagccatttt tcggcgcgcc tgttctggag tcccagtgca 2048701 ttaacgcaac tgcttcgctg taatgtgaga ttctttttaa aagatcaaaa aattcttttt 2048761 catatgtatg tatctccata tccattccct ccctattcta gccgttccat tacaggctaa 2048821 tggaaggggg tatgaaagtc aaattgtttg tataaaaggc tgccggtatg ttttgtggca 2048881 gcctttttat tcagttgatc gtcatttgat tttttggcgg aggtgttctc cgctttttct 2048941 gcttgatttt tttatctacc cacactgttg ccagcggggt taagagcgag gtgacaataa 2049001 cgcttgtcgc gataattgca gttgccgact cagcaactgg cgcaaatgag gcattcgctt 2049061 ccgctaatgc atatggcacg gctacagccg cccctgccgt agaagaagcg gccactcccg 2049121 cgacaccatc tccccgcgca ataaaacgat caagcaaaaa caaagaactg cccgataaaa 2049181 tgacgacaga aactccgata aaaatgccga gcagccctga ttggatcagc attccaaaat 2049241 tcaaggtatt gccgagcgaa aaggcgaaaa atggaatgat cgccggcaca accttgctga 2049301 ataagtctct gagatcatga tccagatttc caagtataca tccaagtaaa aacgggatga 2049361 ctgtcgctgc cagcgtttcc catgggaatg cggcaagtcc cgtcacacca aacgtcacca 2049421 tggtcataaa aggaccagat tctgtactga taaaggcgaa agcgcccgca tcctcttttc 2049481 ttcccatgtg attcatgagc gccaaataca gtccgccgtt cgtttcattc attaccgcga 2049541 caattgctaa aacagaaagg cctgcaaaaa agccggattg tatgccatcg tcaggtataa 2049601 attgcgctgc gatcacgccg agcagcgccg caaatccgat cttccccaat aataacgtga 2049661 ttccttttct tgcgatatag cctgaagaac gaaaatcaat cgttgctcct acgcaaaaga 2049721 taaaaacacc cagtatcggc agcgttccgg taatcaaagc acccgtaaac cctccaaaga 2049781 actccgctgt tccaggcgca aacgtgttga gcgccgctcc aagaaatagc ggaataatca 2049841 tcattccgcc aggtacccgt tcaattgtcg ccttgatttt catattgtgg attctcccat 2049901 cctccggtta tgaaaaaaca attccactta cacttggaaa acagcctgca aatcctcttt 2049961 tgaacagctg cccaactggc tgccgactcc gacggcgcca gctccggctc taagccaatc 2050021 aggcacttca gacggatgta tcccgcctgt cggaataaag gtcacctgcg ggaaaggacc 2050081 cgctaaattt ttcataaacg gaatgccaaa cacaccgctt gggaacagct ttaatgtcgt 2050141 aaaaccgaat gtcagcgctt ccataatttc gctcggagtc aagacgccgg ggatataatg 2050201 tgtctttaca aaagatagat gttcagcaag atcagctgaa aaacccggac tgacaataaa 2050261 ctgcgcgcca gccttagcag cttccccagc ttgctgcgcg ctgatgaccg tacccgcgcc 2050321 aattaaaata tcttccctat tacggaagga ttcgataata tctgatgccc cgggggtcgt 2050381 atacgtcact tcaactgcac gaatcccttt atctaataaa ctctcaatct gctgacaggc 2050441 ctcctgctta tcctttgaac gaatgactgc aatcagcttt gcttctttca gacggttttc 2050501 aacgactttg gactccatat taataatccc ctttcttttg gtgaaccgtt ctttgagcag 2050561 ataaaaaaga agctaatttc tccctggtcg gcaaaccgtc catatccccc ggtgcctgca 2050621 cttgcaaagc gccaatcgca tttccccttt gcaccgcatc cttgtacgac aaaccgtcta 2050681 ggataccgct gattacaccg actgcaaatc cgtctccggc gccgaccgta tcaaccaccc 2050741 ggtcgacccg gcagccttct agaaatcctt cacttgtccc cgttttaaag taagcgcctt 2050801 cttttccaag tttaatagca acaaagctgg cacctttttt caaataatag tcggcaatgc 2050861 cttcaggtgt tttttctccg gtcaatagct ctccctctgc gatacccggg aaaaaccagt 2050921 ctgcaagccc agccagatca ttgattgtgt gtaccattgt tgcttgatca ggccaaagcg 2050981 aaggtcttac attagggtcg aatgaaatgg tcttccctgc gtttctcatg tcgttcatga 2051041 catgatacgt gaagtctttc atctcggctg ataaagcagg cggaatacct gtcacatgca 2051101 aatggcctgc gcattgaaaa taatctctcg gatattcagc tgtagttaat gtgcttgcag 2051161 ctgagttttt cctatagtag gtaacttgcg ggtcgccttc tttcactttt gacttcagca 2051221 gcagcccggt gggattttcg tcctgcgagc ggatcacgcg ggacacatcc actccctctt 2051281 ttttaagctc ttgtaaaata aacgttccga gctgatcatt gccgaccttg ctcatccatc 2051341 ccattcgaaa tccgagtctg gcaaggccgc aggcgacatt gctttctgct ccggcaagcc 2051401 ctttagaaaa agtggatact tcatgaaggc ctccatactc atttgcataa aacatggcca 2051461 ttgattcccc gaatgtcacc gcatcaagct tcatctcttc ccaacctcct cttagttgag 2051521 ggcacctagg attaaagtga ctttctcatg atgacttttg cctctaattc aatggtttga 2051581 ggcgctcctt tgtcaccttc aatccttttt aatacacgtt ccatcgccgt cctgcccata 2051641 tcatgtgacg gctgggcgat cgttgtaatg cctggaccga tcagtttgta ccactccgta 2051701 tcatcgaatc ctgcaatccc tatatcttga gggatgcgca ggccaagctc ttccatacag 2051761 ctgatgattt tcagcataat caagccattc aaagccagaa tcgctttttt ttgctccggc 2051821 atttccttgt gaaaagaacg aagctccgcc ttaagctgct ccttgtcctt tacgtcaatt 2051881 tcatgcaatc tgacaagccc gttcacattt tgaaccgaag ccatttcctg atacacagct 2051941 gctctttctg cacgagggct gatagaggaa atcggttcgg taaacagcgc gacatcagta 2052001 taccctttgc tgtacacctt ctgaagaatc tcttttgtga tccatctgtt gtcagtcgtt 2052061 acggtatcca gtttcagatc cggcagtttc cggtcaatta agattgttgg aatttgctgt 2052121 tcagcaaaag cgcggagtac atccttgttt tcccctgttg cgtttaaaat caagccctca 2052181 accgaatggg cttctagctt taagagcatt tcccgctctt tttcaggact gttatctgtg 2052241 ttgcacacca taatgctgta tccatattga tcacaaacct cttcgactcc cctgaaagca 2052301 gcgaccgaaa aaggatttgt aatgtcagcc acaacaaatc cgattaactt gctttttttt 2052361 attttcaaac cttgtgccat tttactcggc cgataattca attctgcgat tgccttttta 2052421 atgtttttca ctttttcagg agaaatcgcg tcaatttttc cgttaatata gcgggaaact 2052481 gtcgatttcg aaactcctgc acattcagct acgtctttga tggttgtatg gcctgttgtt 2052541 ttctttttca ttcaagtgct cctgtatctc atatatttga aaccgatttc aaaaccgtta 2052601 caacaaaaga ataccataat tttaaaattt gggaagagtt tttttaataa tatgtcaatt 2052661 cattattttt tcgttgactc ttttcactat ttatcctaaa attttctttg aaaccgttac 2052721 caaaatattt tcattcaagt gatgctgaaa tcctaaccaa gggggaaata taatggaaaa 2052781 tcgttattct gtacatcctg aacaagtaaa acgctttaca acagaggagc ttcgcagtca 2052841 tttcttaatg gattctttat ttacagaaaa caaacttacg atgtattact cacatgaaga 2052901 ccgggttgtc atcggcggag cggctccagg gcaaagtgaa ctgaagcttg atgcaggtga 2052961 ttttctaaaa acagacttct ttttggaacg gcgtgaaatc gggattatta atgtcggcca 2053021 gcctggtgcc gttagagtcg gcgatgatga atatgtgctt caaacaaagg attttctcta 2053081 tattggaatg ggcaatcagg atgtatcgtt ttcaagcctg aacggggaaa aagcgaagtt 2053141 ttacttcgtc tccgcttgcg cccacaaaag ctatccgaca caaaaagccg ccctatctga 2053201 actgacaccg gaccgccttg gtgatgatgc agcgtctaat gtcagaagtc tgtacaaagt 2053261 cattcatcag gatggcatta aaagctgtca gctgatgatg ggaataacga tgttagatca 2053321 aaacaacaac tggaatacca tgccagcaca cgttcatgac cgtcggatgg aggcttatct 2053381 ttatctggat cttgaaaagg actcaaaggt atttcatttc atgggccagc cggacgaaac 2053441 acgccatctt gttgttggaa atgagcaggc tgtcctttct cccgcttggt ctattcattc 2053501 tggcgcagga acatcaaact atagctttgt gtgggcgatg gctggagaaa attacacatt 2053561 tacggacatg gatctcattc caatggatgg gctgaaataa gatgggttat ctacatgacg 2053621 ccttttcatt aaaaggaaaa acagcgctgg tgacaggccc gggaacaggg atcggtcaag 2053681 gaatagccaa agccctagcc ggggctggcg ctgatattat cggcacatca catacaagca 2053741 gtctgtctga aacacagcag cttgtggaac aggaaggccg gatatttaca tcttttacat 2053801 tggacatgag caagccggaa gcgataaagg attctgcagc tgagctgttt gaaaacaggc 2053861 agatcgacat ccttgtcaat aatgccggca ttattcatcg ggaaaaagcg gaagattttc 2053921 cagaagagaa ctggcagcac gtactgaatg tcaatctaaa cagcctgttt attctgacac 2053981 agcttgctgg caggcacatg ctgaaaagag gtcatggaaa gattattaat attgcctctc 2054041 tcctgtcttt tcaaggcggc atcctcgttc cggcttacac cgcgagcaaa cacgctgttg 2054101 ccggtttgac aaaatcattt gcaaatgagt gggcagcgtc aggtattcag gtcaacgcaa 2054161 tcgccccagg ctatatttct actgcgaata caaagcctat tcgggatgac gaaaagcgaa 2054221 atgaggacat tttaaagaga attcctgccg gccgctgggg ccaagcggat gatatcgggg 2054281 ggactgcagt ctttttggca tcacgtgctt cagattatgt aaatggacat attttagcag 2054341 ttgatggcgg ctggctatcc cgctgacaaa taaaaaagct gacgaacgat cgtcagcttt 2054401 tttccattac atcatgtgcg gttcaacagg caagaccttt ttgacctcat caatgatgcg 2054461 ttcattttct ccgccagcgt aaatgtgaat cgagccgctg tcttgattcg agcgaatcag 2054521 gcgcccgatg ccctgccgta cacgtaacaa catatatggc agatcaactt cttcgaacgg 2054581 atcttttttc gctccgttgc gcttcgctgt aaatacagga tcgtgtggcg ggaacggtaa 2054641 tgaccaaatg gtaacattct tcaatgcgtc accgggaatg tcgagtcctt cccataagtg 2054701 aactgaacaa agtactgttt cttcttcctc ttggaatttc tctactaagc tgctgatttc 2054761 ctcatcacct tcgaagaaaa ttggatacgg cagctcccat gccgccgaca gctctttaaa 2054821 ctcgtttaat tcttcaaaag aagggaaaag caccagcgtt cttcctttgt atcgtttgat 2054881 tgtttcaatc gtttcagccg ttttttgttc agcgtccata tctgtttttg cgtatagatt 2054941 aatactcatt tgctcgtcat aatcataagg ggaatcaaca gttaatgaca aataatcatg 2055001 aatcccaaga ctgtcggcaa tataatcaaa cgaaccgcct tctgacagcg tagcagaaga 2055061 aaagatataa ggaattttct tagaaaacac tttttcgcca agtacttctg ctaccgttct 2055121 cggcatcacg acaaaggttg attctgcttc ctttttctcc agccagctga tcgcatcctt 2055181 ttgatataga gataatgaat acgccatttg ttcaacatat tcttccacta ctgacagttc 2055241 gtattgatca atcgtataca tttcagactc aaatacaagt gcctcaccga ttttatcaag 2055301 taaacggcaa agctcgtccg ccgccttttt gacacgatgg tcatttttta tttctaaacg 2055361 gtgtgaaccg gctacttcct ttgattcttc agaaagaaca tagaaaaatt cgtcgtttgc 2055421 gagaagcgca tcttcaatca attctgcaaa ctcttctctg atgtcatttt gcagcaatcg 2055481 ttctaaaaac aattcaagag tagactgctt cactctatag gttagcgctt tttgcgcagc 2055541 aaactctaac aagtgcccct catcaaatac aactgcacta tgatcaggca agagcggcag 2055601 ctggccctct cgtttgcgtg attcttccgt ccacacatgc tccatataaa aatcatggga 2055661 acaaatgatt aagtccgttg acttgcggta gtaatctctg gaaagtgtca gaccgcatct 2055721 gtgtctcata tcacaagtca gacagtcctg aaacgagtcg tagcttacgt cagaccactc 2055781 ttcattcgat agatttgcgt actgcttacg gtcgccatac ggataaaagc gctgcatcgc 2055841 ctgggactcg tggacaaatg acggtaacga ctcataaaga tccagccatt tatcatcatc 2055901 agaacgctgc attgtttttt caagcttctt caagcataaa tattgctcat gtgattttga 2055961 cagccttgta tcaattttca gatcaagatg ctcagccagc ttagaaatat cgccctcttt 2056021 tttcaccagc tgttcaatta atgtttcatc cgcacaagcg atgatggcag gtttgccgac 2056081 ataccttgca tagctgattg caaaaagaag atataccagc gttttccccg ttcccactcc 2056141 agcttcggcg aacatgactt ttttctcttt aaacgcccgc tccagctgaa aagccataaa 2056201 tacttgctcg tcccgaagat caaacccttt ttcgggaagg atatcgtaaa acacgtcacc 2056261 aatccaattg ttcaattctt cataaaaatt ctttgttttc gttaaagaaa aaggcaaacg 2056321 tgatgttgtc acctagttcc aacccccaac tattcgacat tcagaccacc aataatatca 2056381 ttttccgctg atgaatacaa taaaaaactt ggcaatgcca agttttttgc agtttactta 2056441 cgattgatca catgcgacga taaaaaagga tggtctgttg aataaatatg ttctaccgct 2056501 ttttctaaat cagtttgcgc atgcgaaatc acagacggag acgaatcagt cccgagctcc 2056561 ttcagctcgt ttgctgttgc gtcaagcgcc ctttgaataa gattaaaatg ttcgctgttc 2056621 agcatgagat cacctctgat ggaaataatc atcattgtat gcgaactttt cattttatat 2056681 acatgcttta ccgcatgtta tcaccgaaac atgcacaaac tacacttgat attccgtctc 2056741 cggattatcc gtcttatcaa caatattcta tcagggagtg atgttgacat gagttataga 2056801 aaccgattag atcagcattc tgaactgttt catcacaatt ggacgcggcc taaacgttca 2056861 aagtctcaag taaacggtca cactgaaatg tcccaaacca acattatatt gagaagcaac 2056921 gcgaaagctc accgttggta acgatagaat agggctgaaa gatgaaagaa gacgcatgca 2056981 gagcgtcttc tttttatgcg ttttctgttt tcttgcgctg cggtcttact tttgaccagt 2057041 attgataata atccgtttta ataaacccgt taaagagttt tcgtttcttc gttgcttttc 2057101 tgccatatgc ttcctcaaag ttttcatttg atgtcagcat atacacagac caagtatcaa 2057161 gcggctcgaa cgcctgcccc atttctttgt acatctgctc aacggctttt ttctcgccga 2057221 gacgctctcc atatggcggg ttgccgacaa ttacgccaaa ttccagattt gtggtaaagt 2057281 ctttgacctg catctgtttg aactggatta gatctcccaa tcctgcttcc tctgcatttt 2057341 cttttgcgat ttgaaccatg cggtggtcta tgtcgctagc gaaaattgta agcggctgat 2057401 cataatttgc cttttcttcg acttcaagcc gcgctttgtt ccacagatct ttaccgatcc 2057461 attcccaatc ctctgataca aaatcgcggt tgaatcccgg ggcgatgttt tggccgatta 2057521 gcgccgcttc tatcgcgatt gttccggagc cgcagaaagg atcaacaaac gggcggtcag 2057581 gcgtccaatt ggttaattgc accaaagcgg cagcaagtgt ttctttaatc ggcgcaccgc 2057641 cctgatcgac acggtatcct cgtttgtgaa ggcccgtccc tgatgagtcc agtgtaatca 2057701 aagcctgatc tttcaataaa gatatttcca ctttatactc agcacctgtt tcttcaatcc 2057761 aatcattggc tttgccggac tgcagcttga gcttttcgac aattgctttt ttgacgatcc 2057821 gctgacagtc aggaacgctt gcaagtgttg attttaccga ttttccgatg acagggaatt 2057881 tcccgttttc aggtataaat gagcgccagt taatcgcttt cgttttttca aacagttcat 2057941 caaatgtttt cgctttaaaa gaagcaacct gaacctttat gcggtcggct gttctaagcc 2058001 aaaggttcgc acggcagatg gcaagtgcat caccttcaaa aataactttc ccgttatcaa 2058061 ccttgcattc gtatcctaaa tctcgtactt cctttgcgac aacagcttca atgcccatcg 2058121 gcgccgttgc aattagtgta tacttcttca tcgtatcacc ctgtctttta aaacttttct 2058181 cttttcaaga taaaagctct ccttatacgg gagagcttgt tttcatcatt ttaaatgtaa 2058241 gtggtctaac gttctgtaag ccatgttttg ttccatcgta ctgcaaacgg ctcatcacct 2058301 cgtactcagg cggcaatcat ctatctacag aaagcattct gtccttctct ccgttgaatt 2058361 ccgttaagaa ggttccccta ccaaaatttg ggtttctcgc tcgaggggtt taccgcgttc 2058421 cactctcacc atttctagtg agacttcgtc actgtggcac tttcaaggat actcagccat 2058481 atccgaagac gtaggctttt ttcctgccgt cagcctctaa agactgccct agcttatgac 2058541 ttcgctaggc acgaacacta cgggcatctc agcaccgtgc gagcatggac tttcctctac 2058601 agattcaaga tctgcagcga ttacccgaac gttaagaaca tgaattatta tataacaact 2058661 gattacaatt tacaagcgcc atttttttca agcgtgatca atcataaagc ttgctgccaa 2058721 aaacgtgttt ttctaagtta gacagccgtt ttaaaatatc aaagtttgtt gtgttagatt 2058781 gcacaggctg ttttttgctg gcttcttcaa gctgtttttt cagctgcaga ttttcctgct 2058841 gcagttcttc aatttcttga tggaaggttt cataatcctt aataatcata tctaaaaatt 2058901 tgtcaacgtc ttcttgcttg tagcctctaa cgcctgtttt aaattctttt tccaaaattt 2058961 ctttcgcaga aagctttact ttatcagcaa gcatcttttt cacctcgtat cgtgaatcat 2059021 cacatatatt ttttcagaaa tctgtacggt tgtcaaattt ctctctcatt gttagtagct 2059081 gtcttcctcc actgtcactc tcaagtcatc cattgtaata aagtagatgg gatagccatc 2059141 ctgttcgcgc cttttttccg ctgtcccaag catatactta ggggagcctt ccttttccgg 2059201 gtcatataaa agcagaagcc cgtcggactt atcaatgaag aactgatttt tttgtttgaa 2059261 ttgaagcggg ctttcataag gacggtgagt caggcttgct tcatagtctg cctgagccag 2059321 aactgcttca tactgttctt tattcggttc tttccagttc ttttcctgct cgtaaaatgg 2059381 tgtgatgaca gctaccttta agtcagggta ttcctcctgc aaatcatatg cagcttctgc 2059441 cgcccacagc tcaactccaa gctggcccga aattaaaatc cattctaatc cttcatccaa 2059501 aaaagcaatc agccggtttt taatggcttt ttttatgtaa tacagcgcct tgtcatcctg 2059561 cttaaatatc cccagttcaa acggtttata gcccgttatt gccaatactt tcatcatttc 2059621 acctgcttta aaaaatgggg ctcccgtggg ccccatttgt tgtgctgcat tgtttacacc 2059681 atcaagctgc acgttttcca tactagtagt cgcagcaagg ttttcctgct tgaaaatgct 2059741 gatgcgtagc cgggtcaaca tttgagaaag tgtgtggaaa gtagtgaacg tgctgaaaat 2059801 gctggtggtt tacgtttgtt gtatgctgtg ggtgaatgtg cggcacgata gtcttcgaaa 2059861 acgtatggtg ttcacagcaa tgagtaggat ggacaattgg cgccatcata tgcggtctgc 2059921 agtgatgcat gataaaatcc cctttccata aactttatta caatactaag ttatgaaaaa 2059981 taaggggtac atgttctgat gcaaagacct attttaaaag tgtgcaatta agctgtcttt 2060041 aaagtttgaa aacacaaaag caatcaaaaa taccacaaca aagaacaagt aaaaaacacc 2060101 cttatacata ccaactctcc ctttaaaaat aactaacgtc attttacagg attcgccgct 2060161 attctacaac aaaatcaatg tgaattcagc aaaaaaaatt catggcgaaa caagtcgtct 2060221 tttgcgcttt cccggggaat atttaagagg aatatttcct ctttagccgg gcaattctca 2060281 catgcagttt ttcagtttct ttctctgata agcatgccgc atcgctaagc gattgctctg 2060341 ctacttgcaa tgcttttccg aattcttttt tcttatgctc aaaatatttc gcgagctcta 2060401 ttacagcagc gtatctgcac ttctggtttt gcgagcggga cagcttttcc caaagcggca 2060461 ctgcttcttc caagcggttt tgttttttgt acaggagcga taaatccagc cgtgcactgt 2060521 cctggtcctc aaacgatttt tctataagcc tttccaactg cttgatcgct tggtccgttt 2060581 ctttatgagc cataaaccat ttcgccatag cataggcttc actgtgttct tttggcgcat 2060641 gtgattctga aaggattttt ttagacatat ggatgtacaa tgaaatgagt gataacacat 2060701 ccatttcatt atgatgcagg acacctttta aaagatccgg ctcttgcgcc ttgataaaat 2060761 gaaagtaaag cattggcgcc aagtagcccg gtgtgtcttc tagcctgcgg atgccgagct 2060821 cctctttttc aaccgtgcca agagatacac ggtccatttt gtgtttccac aggcgtctag 2060881 ctccatgcaa aagatcaaag tggccaaact ccggaagctt cggaagtctg tcacggatca 2060941 aggtgtgcct tgttttcacc tgcggccaat caaaggcttt gccgttgtag gtcacaagtg 2061001 atgtaatgtc aacctcgctt aaaaagcttt ggtacaaggc gacttcgttc cccggtttgg 2061061 gcaaaagatg ctgtttgact gtcactcggt cttcatatac tctcgcatgc ccaagcaaaa 2061121 aaatggtatt cccagctcca cccccaagac cggttgtttc tgtatcaaag aaaaagaggt 2061181 tgtttttgtt ataccctttt gctgacaatg tatgcgacag gccgctttga ttccacagtg 2061241 tgatcacttc ctcaagctca gaaaagctgt ataacccatg gcggtgagaa agcggatatt 2061301 ctacttctct gatgaggcaa tattcatctt cgaagatgaa aggcttcatg ccaaaagcct 2061361 cccactcttc taaaaacggg atgtcatcaa agtggttttc ttgtttgcct gcttctattt 2061421 tttgttctcc ttcgtcgagc gccatgtgct ttttcatccg ttggagtttc ccttttaatg 2061481 acatatccgg cctccctcct tacgacattt gatccaacag ctgcaaaatt ctttcctttg 2061541 cttttatccc ttctatttcc gtacctatac aagacggaca gccgtcatga caaggacaat 2061601 gtgtaatcag ttgtttcgcc gcttcattaa tgtctgaaaa acgtttaaag acttcctccg 2061661 ccaaaccgat accgcccgga taatgatcat ataaaaatat ggttggcaat ccggtatggg 2061721 ctgctttaat ttgagaaaca acatgaacat catttcgatc acacatgata tacacaggga 2061781 caatatgctg cagcacattc gagatgccaa gaagcagctg ttccagtgtc ttttccccga 2061841 tgtcttcatc cgctgttttg atttcgagcc aagctgcact tgtatgcagt tcttcttccg 2061901 gcaaatgaat aggtccagac ccaatatttt caaaagtggt catttttatt tttttaaaaa 2061961 tggtcggcag ggcattgaca gtgacgtctc cgtagtgcaa tgacgtacgg cttttttctt 2062021 tcgttttatc gatttctaat accttcagct gaactgccag gtttgcatcc gtataatatt 2062081 cgacatcgac ttttctgaca tacgcctttt tatggtccca atcgagcttc tcaacttgat 2062141 actgaacgcc ttcatgcaaa taaatcgctt catcatgcaa aagcgtcatc gcactaaaac 2062201 ggtccatttc accgataatc cttacatttg caatatccga ctgatcaact ataacgacat 2062261 tttcctggga ggcggaacgc aaactgatgt ttgacgcagg gaacgactca cttgcccaat 2062321 ggtaccgttc gccgttgcgg tgaagaacag cctcttcctg aagatactca agaatatcac 2062381 tgacttccat ggctccaaat tcttcatcag ctctaaaagg aagctcataa gccgcacact 2062441 ttaagtggtc tactaaaata atcaaattct ccggattgat tcttgcagat tccggcgaac 2062501 gattaaagaa atattcagga tgccgcacaa tatattggtc aatcggtgtt gaattggcta 2062561 ccatgataat caaagattca ccgtgtcttc tgccggctcg tcccgcctgc tgccaagcac 2062621 ttgcaacact tccgggatac cccgtcatta cacacacttg cagctggccg atatcaacac 2062681 caagctctaa ggcattcgta ctgaccactc ctaaaatgtc gccttctctc agtcctcttt 2062741 cgatttctct tcgctctttc ggcagatagc ctccccgata gcctctgatt gattttgttc 2062801 caatctcttt tttcacaagc tcctgaatat ggcttaaaat aatttccacc cgaactctgc 2062861 ttctggcaaa aacaatggtc tgcactttgt ttttaaggaa ctctttcgcc agttcattca 2062921 cttctgcggt tgcgctcctt ctaatattca gcggtttgtt cacaattggc ggattgtaaa 2062981 acacaaaatg cttgcgtccg ctcggtgcgc cgttgtcatc gaccagccgc atcggtttgc 2063041 ctgtcagctg ctctcccaat tcctttgggt tggcaatcgt tgcggaagta caaataaaaa 2063101 ctggatcact tccataaaac cggcagatcc gcttcagccg ccggatcaca tttgccacat 2063161 ggctgccgaa cacacctcga tacgtatgaa gctcatcgat gacgatatac ttaaggtttt 2063221 caaacaaact gacccatttc gtatgatgcg gtagaatggc agaatgcagc atatcggggt 2063281 ttgtaatgac aatatgacct gcttttctca ccttttgtct gattgccgga gacgtatccc 2063341 cgtcatatgt aaagctttta atatcaatgc ccatttcatc aataatttca tttagctcgc 2063401 tcttttggtc ttgtgccagc gctttagtcg gaaataaata taacgcccgg tttgtttcat 2063461 cttgggcgat ggactgcagg actgggaggt tgtagcataa cgtttttcct gatgctgttg 2063521 gcgttacggt aacgatgctc tctccttttt gcacatattg aaaagcggaa tattggtgag 2063581 tatatagttc atcaatgccc cttttcgaaa gggccgcttt gattctctcg tctatacttt 2063641 cgggcatagg ccttgttttt gcttcccgag gctcaatttc atgccaattc acaacgtttt 2063701 catttccttt taaatcagaa atgagttcag tcagtgattt ctttttcatt ctttacacct 2063761 ctttgtcaag tacagtttac cgaatatttg tttgcatggc taggtgcaaa ttttatacag 2063821 ttgaataaaa aaagcaaggc atacgccctg cttatttcgc ttttattgta aagagctttg 2063881 attcgccttt acgagcagcc ttttcgcctg ccgataccat tgatcctaca gcctcaccat 2063941 tcattataac gattgggatg actgtgctgc tcgctttttc ttttattaat tccaaatcac 2064001 atgtaatcag cgggtcaccg accttcactt tatccccttc tttaatgtgg gcagtaaatc 2064061 cttctccgtt catattgact gtctccagcc cgacatgaat taacagctca attcccgagc 2064121 gagtccgaat gccaacggcg tgtttggtgt ggaaaatctg aatgacttca ccttcagcgg 2064181 gagaaacgat ttcaccgcta gaaggttcca ccgctattcc ttctcccatc attttctgtg 2064241 aaaaaacagg gtccggtaca tctgacaggt ccattactgt accgtctgcc ggagaataaa 2064301 taacctcttc tgtcaccttt tcctgaattt tgcccattcc gaataatttt ttcagcaatg 2064361 tattttctcc cttctcattc acttcaaccg ttatcccttc attcaccact atttaaccac 2064421 actttcaatt ttgcttcaat ttataacaac atctggcata gacgcataat ctggttaaaa 2064481 aaggcggtgg cgatattgga attccatgat gacaaaaaga acgaactgca aaagaaagaa 2064541 gaaatcataa cggaggcaat cgacactctt tttcaatcct cagcgttcgg caaccttata 2064601 aacggatttc agaacctaat caactcgagt ttaaaggatg tgcagacgac catacatgtc 2064661 agagaaagag atactgggct gtatatcgat attaccattc cggcgacgtt tcgagatggc 2064721 gagatcgtcg ttgatgttaa atcgaggtat ctccatgtaa cactccaaga aaaacagaaa 2064781 caccaaaatg aggctacctt tacaagcatg acaagaacgg ttcagctgcc ttatgaagtt 2064841 cgccaagaag atatggaaac gtcttggaac gagcagacaa tgacactttt ctttccaaaa 2064901 aataagcatg aatgaacgat tcattcatgc ttctatcatt taaaaaagct ggtaaatccc 2064961 tttattaaag atccgacctg attcattgca ctcattactt gacctgtcgt atccatcatt 2065021 ttattaaaat caaattgccc attggctttt ttgaactgcg acataatgct ttgaaattgt 2065081 gaaggctgct gttgattagg ccttgggata ggataagggt tagaaaatac aggcggctgc 2065141 ataggcatag gctggatcgg agcataaggc tgataataat cctgctgtcc ataatgctgc 2065201 tgaggcagtt gttgctctaa ataaccgggt gcagcctgct gataatatcc ttgcatatgc 2065261 tgaggataat aatagcccat ttgccgagga tagcttcgag agctcccgtt cattgcgatt 2065321 cccccctaaa cacaacatat ttctcttcta tatatgtatg aatgacttct attgtttgtg 2065381 tcacaagtga tgattagcat ttgtcaaatt gtgtcgaaag tttaaatttt ttaaaaacag 2065441 aaaaaagtcg aatcattatg gtaccatatt ttcaatacag atgagagggg atgcaccata 2065501 atgaacgtat catacttaag caaacgtttt gcagaaatga agaaatatga aacagactgt 2065561 atgaataaac tgatggactt tgccaagttc ctctatattc aaggacatct cagcataact 2065621 gagtttcgta acagtatgaa ggttctcgaa gcaaatggag cagaaagccc ggcatatgag 2065681 atgaattaac gtccggcccc ctataaaaac gaaaagaaga cagcctttta ccggctgtct 2065741 tctcttgcaa tttcatcctt tactgcgtgc aatgtataaa ggactgactc agtgatgtcc 2065801 ttgaatcgtt ttttatgaat atgatgaaca taagattgaa ggaccaattc caggaaatta 2065861 tcctttacgg cctcaatttg ctctttatgc acatattttg gccggcggac ttttatcaat 2065921 tcaagagcac cctctgccca gcgagcagcc agttcatcat tctcttcaac tgcaggcttt 2065981 atcgtctcaa aaaaatcata agaatgatta ctgttttttc cttcctgata ccgatcagcg 2066041 cctttttcag caacttcaat catttgctcg gtcatttcca gcaaagtttg tgatagcaat 2066101 atctttcacc tcaatgccta tcgtaccaaa tttcactcac aaattcagcc gatgcggtat 2066161 accttctcaa acgcatacct gtgttcaggc gattgataca gctcatttat acaaatatga 2066221 agatctatga tttcttcttc gagcacactt aggcgatcgt tctccgtttc ccgcatctca 2066281 gcctctaatg catttacaga atgattcagg ctttgctcag ctcgcgttaa ttcatcttct 2066341 atatcagaaa gcatacggag aatatctgtc ttgcatacat aaccggacat tcgtgtacct 2066401 ccctttcctt gtctctcccg gttaacattc tttgctctca aggctctttc cttcctcatg 2066461 acaaaactag aagcaaatcg ccaaacaaac aggtattcca cgaaaagctg aagttttcga 2066521 caaaaacacc cgcaaaaatt gtatgatcct cctcattaat gcaaacgata cttgtgagga 2066581 ggtgccgtat gaaaacaaga ccgaaaaaag ccggccagca aaaaaagact gaatcaaagg 2066641 caatcgattc tttagataaa aaattaggcg gcccgaaccg cccttctacg taagaagcaa 2066701 ggaatttcct tgcttcttta ttttttcagc cactgctcca ccgcaaaaag cgcatgaagc 2066761 tggcgctttt tatgtaaata ccagtctgtc aattcaatct gcttcggcaa ttcctcgcgc 2066821 ctaaagaacg ttttctttat ctttccatga aaccaatctg ttttcgttcc gtctaatgag 2066881 tggattaact cagggtagca tgtccttagc ataggagatg ttctttttgt aatcccgatc 2066941 atcttttcca tatcaaaacg ggaacctgtg tgcggcactg tgtgcaaaaa gtgataaaaa 2067001 gaggagaaca attctggctt gaacagcaat tgagacagct gctttcccag ccttatcctt 2067061 tcctccgcct ttgaaaagcg tttcactgaa atgccgtaaa aaaacccatt tgaggaagga 2067121 aaaataacgg tgttaaaatg aaaccagtca cttaaataaa aaggaatcgt gtcaaaaaca 2067181 ttctttttaa acgaaggatt ttgtataata ggtgtttgga tagtgttttg ttcatttata 2067241 atgagggcat acattagccg ctccgtattt cgctcatgcc aaaaacgggt ccattcttcc 2067301 gacataaatt gtgagacgcc aaacacatgc agcagatgaa acagcggttt cccaactctt 2067361 tttgaccagt ggtataaaag aagctgcgga taggcatccg aaaaaataag ccagttcgct 2067421 ctttcatagg ctaaaaagaa ccatttttgc tgtctctcac ggagtccaag ctgaaacaga 2067481 ctgcctttta agtcagtcat tgaccagccg gcattacgag aaacgaaaga agccaaaagc 2067541 gaccatttga tttccggatg acggtcgtaa aatgctttat aagcatttgt tcttgaaatg 2067601 ttatccgcgt ttttcatttt tgtctgccgc tcaatccggc tcagaagctt tctgatggcc 2067661 tgttgttctt gcacgttcat tcacttccgt catgattagt ttaataagga ggatgagaaa 2067721 gtgattcggt atcctaatgg aaaaacattt cagccgaaac attcggtttc atcccaaaac 2067781 agtcagaaaa gggccccgtc ttacagtaat cgcggaatga ccctcgaaga tgacttaaac 2067841 gaaacgaata agtattatct gacaaaccaa attgccgtta tacacaaaaa gccgacacct 2067901 gttcaaattg taaatgtcca ttatccaaaa agaagtgccg cagtgattaa agaagcttac 2067961 tttaaacaat catcgacaac agactacaat gggatttaca aagggcggta tattgatttt 2068021 gaggcgaaag aaacgaaaaa caagacctct ttccccctgc agaattttca tgaccatcaa 2068081 atcgagcata tgaagcaggt aaaggctcaa gacggtattt gttttgttat tatatccgct 2068141 ttcgaccagg tttatttttt ggaagccgat aagctgtttt atttctggga cagaaaagaa 2068201 aaaaacggca gaaaatcaat tcgaaaagat gagttggaag aaacagctta tccgatttct 2068261 cttggatacg cacccagaat tgattatatt agtattattg aacagcttta tttttcgcca 2068321 tcatctggtg cgaaaggttg attaacgaaa ggttgagatg ttatgtcaga tcaatttaac 2068381 agccgtgaag ctcgacgaaa agcgaacagc aaatcgagtc cttcaccgaa aaaaggcaag 2068441 aaacgaaaaa agggcggatt gtttaaaaag acccttttca ctttactcat tctgtttgtt 2068501 ttaggcgtag tcggcggtgc tgttacattt gccgtcatgg tttctgatgc gccgtccctt 2068561 gatgaaagca aattgaagac gccttattca tcaacgattt atgataaaaa tggaaaagag 2068621 atcgccgaag tcggcgccga aaaacggacc tacgtctcga tagatgaaat tcccgatgtt 2068681 gtaaaagaag cctttatcgc gacagaagac gctcgttttt atgagcacca cgggattgac 2068741 cctgtccgta tcggcggtgc attagttgcc aactttaaag acggcttcgg ggctgaaggc 2068801 ggaagtacga tcacccagca ggtcgtcaaa aactcccttc tttcacatca gaagacgttg 2068861 aaacggaagg tgcaggaagt atggctttcg attcagctgg agcgcaatta ctctaaagat 2068921 gaaattttag aaatgtattt aaaccggatt tatttttctc ctagagcata cggaatcgga 2068981 aaagcggcgg aagaattttt cggcgttact gatttaagca aattgactgt cgaacaggct 2069041 gcgacgcttg caggaatgcc gcagagccca acagcgtaca acccggtcaa aaacccggat 2069101 aaagcggaaa aacgacggaa catcgtactc agtctgatga aaaagcaagg atttatttct 2069161 gattctcaat ataacaaagc gaaaaaagtg gcagtgaaag acgaaggcgt cgtgtcacag 2069221 aaggaatatg aaaaagcaag tacaaacaaa tacagcgcat ttgttgaaga ggttatgaag 2069281 gaaattgatg aaaaatctga tgtcgatcca tctgctgacg gattaaagat ctatacgaca 2069341 ttagatacaa aagcacaaga taaactagat gaattaatgg acggagacac cgtcggattt 2069401 actgaaggca tgcagggcgg tgtgacgctt ctcgatacca aaaacggaga agtccgagcg 2069461 attggtgcgg gacgcaatca gcctgtcgga ggctttaact atgctactca aactaaggca 2069521 cagcctggtt cgaccataaa accgattttg gactacggac cagttattga aaataagaaa 2069581 tggtccacat acgaacaaat tgatgactca gcttatacgt attctaacgg aaaaccgatt 2069641 cgtgattggg accgcaaata tctagggcct atctcaatgc gttacgctct ggcccaatca 2069701 agaaatatac ctgctttaaa agcattccag gcagtcggta aagatactgc tgtagacttt 2069761 gcaaatggac tcgggcttgg tttaacaaaa gataatgtaa cagaggccta ttctattggc 2069821 ggtttcggtg ggaacgatgg tgtttctcct ctgacaatgg caggtgcata cagcgcgttt 2069881 ggaaataacg gaacgtataa tgaaccgcat tttgtaaaat ctatcgaatt taacgatggc 2069941 acgaagcttg acttaacacc aaaatcaaaa tcagccatga gtgattatac tgcgtttatg 2070001 attacagata tgctgaaaac agctgtgaag acaggtactg gacagcttgc acaagtacct 2070061 ggtgtagaag ttgcaggaaa aacaggaacg actaactttg atgataatga agtcaaaagg 2070121 tacaatatcg ctagcggtgg cgcccgagat tcttggttcg ttggctacac accgcaatat 2070181 acagctgccg tctggacggg aatgggagaa aacgaggctg gaaagaaatc actttcagct 2070241 gaagagcaaa aagttgcaaa gcgcatcttc gcccagctca tcgccgatgt cgatgacgga 2070301 agcggatcat ttgagaagcc tgacagcgta gtggaagcca ccgtagaaaa aggttctaat 2070361 ccggcaaaac tggcagggcc aaatacgcca agcgataaga agctcacaga gtactttgtt 2070421 aaaggcacag ctccttctac tgtttctaaa acatatgaga aagaagaaaa agaggaaaca 2070481 gctaaactgt ctggtttaaa cgtgaaatac gataaagaca atcaatcttt aacgttaagc 2070541 tggaattacg acggagatgc gacctttgct gttaagcaat ctgttgacgg cggcagctac 2070601 tcggaaattc aaaacagctc tgcaaaagag gcagttattt cgggtgtgca gccaggatct 2070661 gtatacaaat tcgaagtaac agccgtcagt gatgatggca aaagtacagc ttccacatct 2070721 tatgaggtgc caaaagctga agacgatgaa gataaaaaag accagcaaca aacggatgat 2070781 gaaaaacaag atgatgagaa gactcaggat gatacacaaa ctgatgattc tcaaaaagat 2070841 gacggtcaga cggatcaaga tcagacagat gattcaacaa acgatcaaga caaaaaacaa 2070901 gacaatacga acaccaatcc gtccgacaac aataaccaag accaatcaaa cgataatgat 2070961 aacgacaaca gtaacaacca ggatacgtcg gatggtgatt cgaactctgg taagaatgat 2071021 tcaacaggtt ctgacacgaa taaaaataaa acagacacat ctaataaaac acaaacaaac 2071081 tcatcatcca ttgaaaaaac aaattaaaca aaaaagccgt cacctttggg gtgatggctt 2071141 ttttggtaca caataaaaaa cctcccgttt taacaggagg ttttatcgat tcatcgcatg 2071201 atatttataa aaatgctttt tcatttcggt aatcagctca tcaagctgaa taaagcaatg 2071261 gtattgggtc ggcttaagaa gaataaattc cactcgttca gcccaattaa tcggctttgc 2071321 gggatatgat ttctccctca gttcttgcca atcgagcgat ttcaccggct cacctgctgt 2071381 ccaatgtaac gaagccagca aacacacaat gccctttaac atttcgtttt ggtcacatct 2071441 cgattttcgt gtttgaaaga ctgggagaag tgatgctttg atgtcatccc acacttcaaa 2071501 taaaagcgga acgtatttcc cgctgtcctc ccatggcaaa tcgccttgta attccgtgca 2071561 gaaatcaaaa tacacgggat tggtctgcaa ggttttcttc atatccgagg aactcttctg 2071621 gccaagactg cgcaagtatt gctcatagga agccaacact tcttttgctt gcgtcatcgt 2071681 ttcaccagtc cttttttatc cctcttctgc ccttctctgc acaaagaaag cagcggacac 2071741 tccgcacagc gcggagattg ggctttacag tgatatctgc cgaagaaaat aagccggtga 2071801 tgcgtaacgg accaatcttc tttgggaacc ttgcgcatca gcgtcttttc aacttccaga 2071861 accgagtcct tccaccggca aatgcccaat cgtttgctga ctctctccac atgggtatct 2071921 acggctatgg ccggcacgcc aaacgcaacg gataccacta cgtttgcggt ctttctcccg 2071981 acccctggca gtttgacaag ctcatcgcgg tctctcggca cttctccgcc gtaatcttca 2072041 ataatcattt tactcagctt ttgaatattt ttcgctttat tacgatataa accgattgat 2072101 ttaatatcct gctgaagctc ttccagcgga acagccaaat agtcttccgg ccgtttatat 2072161 ttttggaata atgttttggt cactctgttt acaagtgcat ctgtacattg cgcagataaa 2072221 gcaacagcca ccactaattc aaaaggattg gaatgaacca gttcacactc cgcatgagga 2072281 aacatgtcac ctatcttgtc taaacagaat tcaatttgtt ttagatttaa cacgattgtc 2072341 accttttcac tttattgttc aagccaattg taaaaaggaa cctgcctttt atactctttt 2072401 tgcggttcat tctgctttgc ttgtacacgc cggaattttt ggctgtgtat ttttgcctgc 2072461 tccacagttt taagcccatt tttcttccat tcaaacaaaa tccggtcaat gtagcggaaa 2072521 ctgagttttc ctgatagtac agcctctttt aacgcgtgtt tgatcagttg tgcgtcatgc 2072581 tgatcctggt cctgccagat cgccagcgtt tcacactcca aaggcgataa cggtcttgcg 2072641 aactcttcct caaaaatggt ataaaggctt ttttgttccc cttctgcttt tctttcctgt 2072701 gtttgattct gtgcaagctg aatatactcg tacagcttgc cccataaagg ctgaagagaa 2072761 tatttctcaa atttgatgcc gttttgatcc tcgcattctt caataaacag aaagcctttt 2072821 tgaataaaca tccgcaatct gtttgtacat tcttcaacag aaattgacat accttcctgc 2072881 agctgattcg gtgtaggaaa atatgatcct ttttctaaat gcattttaat ttttaacagc 2072941 agaataagtt ctgtttcatt aagcccaagc tgtttataat gcgtgagcag aagattgggg 2073001 atggttgatg ttccctgctc ctgcatatca ataaattgct gttttttcat cgtcacacct 2073061 cttactgtaa aggattgtga ttgccccttt actgtaaaaa gtctcccttg caggagactc 2073121 ttttttgttt catttgaatg tattacggat acagacggtt taacagtctt gggaacggaa 2073181 tcgtttcacg aacgtgaggc gctccgctga tccaagctac tgtccgctct aatccaaggc 2073241 cgaagccgga atgaggaact gatccatatt ttctaagttc agcataccat ttataagcgt 2073301 cagaatccag tccatgttct ttaagacgcg attccaaaag ttccatatcg tgaatccgtt 2073361 cagacccgcc gatgatttct ccatagcctt ccggcgcaat caagtcagcg caaagcacaa 2073421 cgtcctcacg gtcagaagcc ggctgcatat agaacggttt taaggacgtc ggatagcgag 2073481 tgatgaatac cggtttgtca taatgttcag caatcgctgt ttcatgaggc gctccgaaat 2073541 catctcccca ctcgatatcg tcaaagcctt tttctttcag aaattcaatc gcttcatcat 2073601 acgtaattct tgggaacggg gctttgattt gctcaagttt tgacgtgtct cttcccaatg 2073661 tgtttagttc aattttgcaa tttttaagaa ctgattgcac gatgaaagaa acgtaatttt 2073721 cctgtacttg aaggttttct tcaaattcta caaacgccat ttccggttcg atcatccaga 2073781 attcgattaa gtgacgcttt gttttagact tttccgctct gaatgtcggt ccgaaagaga 2073841 atacttttcc taaagccatt gccgcagctt ccatgtagag ctgtccgctt tgagacagat 2073901 atgcatcttc atcaaagtac tttgtcgcaa agagttctgt tgttccttca ggtgcgcttc 2073961 cagtcaaaat cggcggatcc acttttacga agccttcgtt attaaagaat tcgtaagtcg 2074021 cgcgaatgat ttcattacgg attttcatga tcgcatgctg gcgctttgaa cgcagccata 2074081 aatgtctgtg atccatcaaa aattccgttc cgtgttcttt tggtgtaatt ggataatcgg 2074141 tcgcttcgtg aatgacttca atatctgtca cagcaagttc atatccaagc ggagaacgct 2074201 cgtcctcttt gacaatccct tttatataga gcgacgtttc ctgcgtcact gatttagctg 2074261 tttggaaaat gctttcttcc acttccgctt ttactacgac accctgaata aaaccggtac 2074321 cgtcccgaag ctgtaaaaac gcaattttcc cgcttgaacg cttattagcg acccaagctc 2074381 cgatcgttac ttcctcacct acgtgcttgt acacttggtt gattgttgtt ttcaacatat 2074441 ttccctccaa aacaagaaag acattcggaa gctcattgcc ccgcgaactc ttttatcatc 2074501 actttattat acccgctctt aactaaccgg gtcaatgcag ataaaaagcg gcttttctgt 2074561 cagccgcttt ttgatctgtt agctatgttt ttctacaaaa cgcttgattc tttcaatggc 2074621 ttcttcaaga agatctaacg atgttgcata agaaagacgg acattctcag gagagccaaa 2074681 tccggatcct ggaacaatcg caactttttc ctcctcgaga agcgctttaa caaattcatc 2074741 tacatctttg aaaccgcaag attgagctgc ctcttttgca tttgggaaca agtaaaaagc 2074801 accttccggc ttcacgcagc tgaaccctgg gatttctatg agctttgcat agatcgtatt 2074861 taatctatgt tcaaatgctt ctctcatttc ttccaatggc tcagaaggcc cgttataagc 2074921 agcaatcgct ccgtattgtg cgattgatgt cgggtttgac gtgctgtggc ttgcaaggtt 2074981 cgtcatcgct ttaataatgt cttcagagcc tgccgcataa ccgattctcc agcctgtcat 2075041 gctgtgggac ttcgatacgc cgtttataat gaccgtttgc tctttcagtc tgtctgacag 2075101 ctgtgcaatg gaaacatgtt tctttccgcc gtatgtaagt ttttcataaa tttcatctga 2075161 cacaatcaag atatcatgtt caaggcacac ttcaccgagc gcagatagtt cttcttccgt 2075221 atacatgaca ccagtcgggt tgcttggaga gttaataacg attgcttttg ttttttccgt 2075281 aattgcattt ttcagctgct caggcgaaat tttgaagtga ttttcctcaa gcccttctac 2075341 ataaacaggc tttccgccag cgagtttcac ctgctccggg tagcttaccc agtaaggcgt 2075401 tggaataata acttcatctt cttcatccaa aatcacttgg aaaagggtat acagagcatg 2075461 tttggcacca gtgcagacaa taatttgaga cggtttgtat tcaatattct ggtcgcgttt 2075521 aaatttctct gcaatgctgt ttttcagttc agccaaacca ccggaaggcg tgtatttcgt 2075581 atggccctcg ttcatcgaac gcacagcggc atcaataata tgctgcggtg tattgaagtc 2075641 aggctcgcct gctcctaagc cgatgacatc atggcctgcg gctttcagtt ctttcgcttt 2075701 cgctgtgatt gccagtgtgg ttgatggtgt taatgcggat actctttttg ccagtttcaa 2075761 cttgaactcc ccctaattcg tcttaaggcg tgatattttt gagaatcttt ccagttgtaa 2075821 agtccacata acttaaactg tattgccctt ctttgtctaa gtacgtcact tcccaaagca 2075881 ggacgtttcc ttctcttgcc agatgaacct ctttttgctt tgaaaccagc ccttcatcct 2075941 ttatgatttt cgccgctttg tcttcagaga ttccctcttt cgcttctttt gagagaattt 2076001 ttgctttttt atcagcagga acccagacat ataatgcagt gcctttttta tccgttccct 2076061 ttacaacata atatttttct tttccgacaa atgtttcgac ttgatcaaca tgggcgagat 2076121 cggtttcttt tttagcttca gcagctgctg cttcgtgccc ctcttccttt tgtgccatgg 2076181 ctgatttata aatgcttgcc gagacaagaa gtactgctaa aaaaataata ccaaaaatga 2076241 cggtaaatat taatgctttt tttctcatct tctcacctac gtacgataaa tggtaaaaac 2076301 ggcttggttt ttgttttctt catccagcgc aaggccgaac atcagattgt ctcttttcag 2076361 tgtacgattc aatgtgtcca caattttata cagatcatca gaatgctcta cattaattgt 2076421 tgaaagaatt tcgattttac tttccatttt ttcatcctcc agtttgaaca aatattgtta 2076481 gtcatactcc atttcaggac acgccatact agtatcacag agcgggaaat ccgcttttaa 2076541 ataaaacacc atcctactcc cacaccgcaa aagccgcttt atgcggcttt tattcttttt 2076601 cccctgcaac ataagcttca agctcgctgt cagtcatttc ggatactgag gttgtcggca 2076661 aggcatcaag aaacagccgg ccgtaaccag cggttttaat ccgtctgtcc aatataataa 2076721 tcgttccctt gtctcccgca gaacgcagca agcgtccgat tccttgcctg aaggtcagca 2076781 cagcttccgg taatgacact gtttgaaacg gattctttcc ttttttgcgg gcaagctcac 2076841 attttgcagc atgaagcggg tgatcagggg accggaatgg gagcctcacg atcattactg 2076901 tcgtcagctc atcaccaggg aaatcaacgc cttcccaaaa atgatttgtt ccgagcagga 2076961 tcgcctgatt ggatgtttta aaagtcttca tcagtttgcc gggacttccg cctgtaatcc 2077021 cttgtgccaa gagctgaatg ccggaagcac tcatgttatg cttaagctcc tggtgaacct 2077081 ttttcagcat atcatgggat gtaaacagca caaggatttt aggctgtttt tcctttgcca 2077141 tcagttcgat ataacgggct gtatcctgta taaattcagg ttgccctgta tcctgaattg 2077201 atttcatttc ttttggaatc atcacctgca tacgctcatc gtaagaaaag ggtgactcaa 2077261 ttctcattgt ccgcgggaaa aagtcactca gtcccagtcg ttcaatcata aattgaaaag 2077321 aaccttcgac tgtaagagtt gcagatgtca gcaccacact atttttgcgc gcgaaaaact 2077381 gatcagccag aagttcacca ggttcaagag gctgtgcgta aatggccact gcatttttcg 2077441 caccctttgc atctatttca atccaaaccg cttcatcgtc atcagagcca aagaagagct 2077501 tctgcaacgt ctgacagtaa tgctgcaagc ctttcatgct tctttggtat tcatcggcta 2077561 aaaagacggt tttgctcttc atgcccttca aatgtttttc cataagggat gactgcgcct 2077621 caaaaagctg ctgcaaatgt gtcagcatgg aacaaagcct ctccgcacca tctgttaaga 2077681 tcgaccagct tttatcctgg ctttctttgt tcaccttaaa cactagacgg tttaagtctt 2077741 ctttaggttt tcttcgtttg acaaaagaat gtacagagct aaagaaagca tcactttctg 2077801 cttgaacgtg ctgaagccac tcttccaatt cgaaaaatga atcaaccggc aggctgtttc 2077861 gctggaatag ctgtctcatc ttttttagaa gtccctgctc cttcagagtg ccgattctgc 2077921 tcaatttcgt atgcaattct atgtacgtgg ctcttttccc taaatgttcg cttgccgcac 2077981 gttcaaaatg gtgtgcttca tcaataataa atgtgccgct ttcgggaagc ctttttttat 2078041 ggctgccttc atcggtcagc aaaagagaat gattggtgat caccaaatcg gaacgcatag 2078101 caatctgttt ggcccgctcg taaaaaccga tcacatgctc actgcgactt cttttatagg 2078161 agtcatcgtc ataagccaat ctgtcccaca gcaattttcc gcctgaaggc aaattcagtt 2078221 ccgctacatc tcctgtattt gtctctgtca gccaaacaag aagctgtgcc tttgtcagta 2078281 cggcatcata attatcatct tcttcatgaa gcacctgctc aaatttatac aggcataaat 2078341 aatgcgattg cccttttaaa atcgccgctg ttaccggaaa tggaaacaga tcttggacaa 2078401 tcggcaaatc ctttgtgaga atctgctgct gtaaaagcgt cgaatacgtg ctgattatga 2078461 ccggcttttt tgatttcttg gcaaaaagcg cagccggaat aagatagcca atcgtttttc 2078521 cgatgcctgg aggagcttca atcagcgcat gctcacgatt ggcaaacgca tcagccacct 2078581 ctctcatcat catcatttgg ccgtctcttt tttcataccc aggcattaac tctgacagcg 2078641 ctttttcatt tcccgcttcc cagctttcga tctcaaatga gaagttctcg tcctcattta 2078701 tacgaacatc gatagcttca ggttctctga cagaaaacga agaaaagcgc gtatagcccg 2078761 gtatctcggt atgtctgttt tcattaatga acatatccaa caaatgcgtc agatcactga 2078821 tgaaatgctg cgaaagcctt cttaactgct ttaatgtcgg ataaggaagc tgccgcagct 2078881 tttcaaggat ttccaaaaaa ataagccctg tcacttcagc atcgctgtca gcccggtgcg 2078941 gctgatcatg ccgcagctga agctcctcgc ttaattccgt cagcttatac ccttcaaatc 2079001 ccggaaaaac aatgcgtgag agctcgacag tatcaagcac ttcacaatct gggagctgaa 2079061 agcccgcctt atgtagctca tacttgacaa atccaaggtc aaaatggata ttgtgggcga 2079121 caaaataagc gccgtcaagc aattggaata cttcttcagc aactgcttca aatggctgtt 2079181 cattctcgac catttgatta gagattccag taagctgctc aataaaagca gggattgatt 2079241 tatttggatt aatgtatttt gaaaaccgct cagtaatttg tccattttcg attacaaccg 2079301 ctgcgatttg tatgatttta tcgcctttct tcggcgaatt ccctgttgtc tctacatcta 2079361 taacaacgaa ccgttgctta ttcattaaaa tggacacctc aattcttgca tacgacaaaa 2079421 gtgtaacacg ttttgtacgg aaatggagcg gcaaaaccgt tttactctca aaatcttaaa 2079481 agaaaacccc cgataaaggg ggcttttctt ctacaaaatt gtacgggctg gttcgttccc 2079541 cagcatttgt tcaattttgt tttgatcatt cagaacagcc actttcggct catggcttgc 2079601 cgcttcttga tcagacatca ttttgtagga aataataatg accttatctc cttcctgcac 2079661 aaggcgtgcg gctgcaccgt ttaagcatat gacgccgctt ccccgtttac caggaataat 2079721 atacgtttca agacgtgctc cattattatt attcacaatt tgtacttttt cattaggaag 2079781 cattcccaca gcatcaatga gatcttcatc aattgtaatg cttcccacat agttcaggtt 2079841 tgcttccgta acagttgccc tgtgaagttt gccgctcatc attgttcgat acatattata 2079901 ttctctccat ttctcgaata tcaataatga tattatctat taaacgcgct tttgaaaaag 2079961 caactgcaac agcgagaatc atctttccag caatttcatt cacaggctcg agttccggat 2080021 aggaataaag ctctacatag tctatggttc cgctagtcgt ttcaatgata tcttttgcag 2080081 cttttatcac cgcttcagga tctctttcac cggcttggac aagttccgca cttgtttgaa 2080141 gggcccgata cagcttaggc gcttcttttc tttcctcagc tgttaagtat acattgcgag 2080201 agcttttggc taagccgtct tcctctctga ccgtatcgac aggaaccaat tcaatatcca 2080261 tgaagaagtc gctgattaac ccatcaacaa cagctacctg ctgcgcatct tttaaaccga 2080321 aataggcacg agtcggcttg actagattga aaagcttcgt cagtacgatc gcgaccccgt 2080381 caaaatgtcc ttctcttgag cgcccgcata acacgtctgt gcgtctttct acatgaatcg 2080441 tgacattctt ttcaccggga tacatatcat gagcatctgg cgtaaaaaga atatcgactc 2080501 cggcgttttc tgcaagagct gcatcccgct caatatcgcg cggatatgct tcaaaatctt 2080561 cattagggcc gaattgtgca ggattcacaa aaatactcat aataacggcg tcgttttctt 2080621 gtcttgcttt gtctgctaag gttaaatgcc cctcatgcag aaaccccatc gtcggaacaa 2080681 atccgattga cttgccctct gaatggtatt gttttatggc ttctttcagc tgtgaaatat 2080741 cagtaatctg tctcatctta ttttcccccg tacaagccgt caagcactgt ctggttcatt 2080801 tgaaaggaat gcttttgttc agggaaagca cgatgtctta catcctgaac atatccgctg 2080861 attgctgttt cgatggtttc atcaatgcgc gtatattgct ttacaaattt aggtgttctc 2080921 tcaacaccgt ggccgataat atcatgataa acgagaactt gtccgtccgc tttcacacca 2080981 gccccgattc caatgaccgg tatgcttagc gtctcggcaa ttttggctgt gagttctgcc 2081041 ggcacacatt ccagcacaag catcatagct cctgcttctt cgcattttat actgtcttct 2081101 attaattttt tggcgctttg ttcgtctttg ccctgtactt tatagccgcc cagtacgccg 2081161 actgactgcg gtgtcaaacc taagtgactg actactggaa tgcctccaag cgtcaatgcg 2081221 cgaatggatt caaacacgcc ttctccgccc tcaagcttca gtgcgtcagc tccgctttcc 2081281 tgaacgatag ccgctgcatt tttcagcgta tcttccttag acaggtgata agacataaac 2081341 ggcatatctg tcacaataaa ggtattcggc gcaccccttt taacggcttt tgtatgatgg 2081401 atcatgtccg caactgtcac accgacagtt gaatcaaggc cgaggacgac cattccaagt 2081461 gaatcaccga ctaaaatcat gtcaactccc gcttgttcag caagtttagc tgccggataa 2081521 tcataagcgg tcagcatgac aatcggttct tcagactcct tcatttttag aaaatccagt 2081581 tttgttttca tgttttctcc tcctcatgtt tagaggagat gatctgccgt tttcttctgc 2081641 aagccaaaaa accttccgtt acaacgagaa ggattcttca ctttctaaag ttcggcgagt 2081701 ttcatccctc tgtcccagtc cttttttgga tcaaggcaga ctgctgcaat gtctatctat 2081761 tttaataata ggtgcagttc gcaggcgata ctgcccaatg gaagtatacc aaaatcaacg 2081821 ggcttgtacc aacacattag cccaattcga tatcggcaga atagattttt ttaatgcctt 2081881 cgttcgtttc taaaagcaga acgccttcat catctatacc taacgcctta ccgtaaaagg 2081941 ttccgtttaa cgttctggct ctcatattag tgccaatacc gagcgcatag ctttcccata 2082001 aaagcttaat cggcgtaaat ccgtgcgtca tataatcccg gtaccgtttc tcaaagcata 2082061 gtaaaatatg ctggatgacg ccggcccgat caattttttc cccagcagct tggctgaggc 2082121 ttgtcgcgat gtccttcaat tcatctggaa aatcattagg ctgctggtta acgttaatgc 2082181 cgatcccaat gatcactgaa cgtacgcggt cttcttcagc ctgcatttcc gttaggatac 2082241 cgactgtttt ttttccgtta atcaaaatat catttggcca tttaatatcc gtttggatgc 2082301 ctgctgcctc ttctattccc tgcacaacag ctactgcagc aagcagagtc agctgcggtg 2082361 ttttttggag cggaatgtca ggccgcaaaa tcaggctcat ccaaacaccg tttccttctt 2082421 gagaatgcca taccctagac attcggcccc ttccggctgt ttgtttgtca gccaccacaa 2082481 gggtgccttc cggtgcgtta ttattcgcga gctcatgagc cgttttttgc gtgcttgaaa 2082541 gaacgtcatg gtaaataaga tgctggccca tcacttccgt ttttaatcca aaacgaattt 2082601 cgctttcact gagttttccg ggttttttga tgagccgata tccttttctt ctaacggctt 2082661 ctacttcata accctctttc cgaagctctt caatatgctt ccacacagca gttcttgaac 2082721 agccgagagc atcactgatt ttttggccgg aaataaattc attgccggcc tgagaaaata 2082781 attcaataag gtcttttctt aatgttgacc gcatgtcttc agccactcct ctatgtgttt 2082841 cttttgattg gagagcttcc ctgtcacaac agcctgctcg atccactgta attcttctga 2082901 cacccatttt ccggccggcc ggtttcgaag cgcaagcaag tccttacccg tgatatcaag 2082961 atccttaagg cttttgatcg gcaggttttg ataagcgtac tgaatgtcct tcagtttctt 2083021 ttcatccagt ttttcgtttt gccgaagctg cgatattttg gccgctgaga gcagtgcttt 2083081 tttcccagct ctgtacattg tcattgcgtc aaggctctgg ccaaacgtat cggcaatgtg 2083141 aatggcttcc ttgatcactt ttcccgggag cttccaggct ttcaggaaaa ggggcgcgtc 2083201 tttcaaaact atgccaaggt taattaaaag agcagcccaa agctcctcac gggatgttaa 2083261 agagaagaat ggaaactcac tcgttgaaat caggttttct cgtttatgat aaaaaccagg 2083321 aagctcttca tacaatctcg tttgaatgag tgtttgaagc gcctggcgag aagctcttcc 2083381 ctgcagcaat ttctcaaact ctatagtttt tcgttcgact gaaacatggg agaggagtga 2083441 tttttctttc gcaatggctt cttctgtttc cggtgaaagc gtaaagccaa gctggctcat 2083501 aaagcgtacg gctctcagca tacgaagcgc atcctcttga aatctatcct caggctttcc 2083561 aacggttcga atcactttct gatcaatatc tttcttgccg ccaaaataat caagcacctt 2083621 cccgtccgct gtcatggcca tcgcattgat cgttaaatct ctgcgtttta gatcctcttc 2083681 taatgatgag ataaattgca cttctgacgg tcttctgaaa tcaacataat cagattcagt 2083741 ccggaatgtc gtgacttcat aggtttcatc ctcccagagc acaataatgg tcccgtgctc 2083801 tttgcctaca tcaacagtcc gctgaaacag ccgttctact tgatcaggtg ccgcatctgt 2083861 cgcgatatcg acatctccga tcgttcgttt catatagctg tcacgaactg cgcccccgac 2083921 aaaataagcc tgatggcccg cttcgattaa gatgcggagc acgggaagtg ctttgataaa 2083981 aactttttcc atgtgatcac tccggttctg ctaaatcggc ataaatctgt tcatactggc 2084041 tgacaatttt tttagaagaa aattcatttt caagcatctc tattgccgcc tttgtaaaac 2084101 gattgcttag ctgttcatct tctaaaatgc tcatcgcgcg ggctgttgcg gccgtaacat 2084161 caccgacatc caccaaaaat ccgctcacat tgttttttat aacctcaggg ataccgccaa 2084221 tgtttgttcc aatacaaggc actccgcaag ccatcgcttc aagcaggaca aggccaaagc 2084281 tttctttttc agatagcagc agcttcaaat cgctaataga ataaagatct tcaacacggt 2084341 cttgatttcc aagcattaag acttggtctt ccaagccata ttttctgata agctcgcagg 2084401 ctgtcgattt ctccggaccg tctccgacta aaagcagctt cgctttcgtt ttgccagcga 2084461 tattgcggaa cacacggatg acatcctgca cgcgtttaac ttttctgaag ttggacacat 2084521 ggatgacgac tttttcatct ggtaaaattc catgtttctc tttaattgcc gctgtgtttt 2084581 tcttcagata cacgcgctcg tctataaagt tataaatcgt ttcaattttt ttctccggtt 2084641 taattaaatc gtatgtttca gccgcaagcg ctgaggagac ggccgtcacc ctgtctgatg 2084701 actcaatagc aaaacggatc agatctttta gagacggatc ataacctaac accgtgatat 2084761 ccgtgccatg caaagtggta acaatgccga tattgcgttt cagcatttgt tttgcaagat 2084821 aggcgcaaac ggcatgcggg agagcatagt gagcatggat aatgtctaaa ttctcccgtt 2084881 ccgccacctc agcgattttg cttgccaatg tcaaatcata cggaggatac ttaaaaacag 2084941 catattgatt aacctcaact tcatgaaaat gaatattggg atgatatgta ttcagtctaa 2085001 acggaatgct tgatgtgatg aaatggattt catgtccctt ttcagcaagc tgcttcccca 2085061 gttctgtcgc aatgatacct gagcctccaa cgctcggata gcatgtgatt cctattttta 2085121 gttttctcat tgttcgcccc caagcacatc atgatcaagc atcagcatcc gtttggaaaa 2085181 gaaaccttcg gcatactcca cgcccgcttc tttaccgtaa agcttttctc tcgcttcaac 2085241 gatttcaata tacccattcg tcagaggagt agaaacggaa tcctttgacg ggataaactg 2085301 gcttttgtag gcgttgaggc tttgtttctt tgcctctatt gtatccgaga tatcaataac 2085361 aaaatccggc tgatgaaaac catttatcat ataatagtaa accttgctga ctttatgcgc 2085421 cggaaggctt ttttcgtctt tatatttatg gattccggcg gaaaagatcg cttcttccac 2085481 cagtgcagcc gcattgccgt gatccggatg gcgatccttt ttatacggca taaaaaccgc 2085541 ttttggccga cagattctga tgacagtgac aattgaccga attgcctgat cactcattat 2085601 taggccgcgg tctggaagcg ttagctgaat tcttttatct gcgcctaata tgcgggctgc 2085661 ttcagctgct tcttctttac gcaaactgac cgtaccgtta gaagagagtt ccgcttctgt 2085721 caaatcgcat atcattactt ttttttcctg tttgacaaac ttcgctattg tgccgcccat 2085781 tccgatctcg acatcatcac tgtgggcgcc aaaagcaaga acgtcagcat tatacattcg 2085841 gctcttctcc ccgaagaagg tcacggaatt cgaaaacacc ttcatcaagt gtgcgcacaa 2085901 gaatttccgc agtacccata tttgtggcga gcggaatgga atacacatca cataaacgga 2085961 ttaatgccga gacatccggt tcatgcggct gcgcggtcag cgggtcgcgc aaaaaaatga 2086021 caagatcgag tgcattggca gcgatcagtg caccgatttg ctggtctccc cctaaagggc 2086081 cggattgaaa acgttcaatt tgaagacctg tcgcctcatg aattttcaac cctgtggttc 2086141 cggttgcgta tagatcatga ttctttaaaa tatcccgata ggcagtcgta aattgaacca 2086201 tatcctgttt tttcttgtca tgcgcgatca aagcaatttt cattgtttat ccccccgtct 2086261 aatcaatgat attttctaaa ccatacacaa gctgatcaat cttcatgact tgttcgactg 2086321 acagtttaac gcctgacatg aaagaagcac ggttataaga atcatggcgt atctgaagcg 2086381 tttggccatc catgccgaac atgacctcct gatgcgcgat cagtcccgga agacggacgc 2086441 tgtgcaagcg aataccgttt tgctccgctc ctcttgctcc tgggagaatt tctttttcat 2086501 ccggatgtcc ttgctgcttt tctttacgga cttctgaaat catttccgct gttttaagcg 2086561 cagttccgct tggtgcgtca agcttctggt catgatgaag ctcaataatc tcaacatcct 2086621 caaaatagtt ggcagccatt tttgaaaatt tcatcatcag tatcgcaccg agcgcaaaat 2086681 ttggcgcgat gatggctccg atcccttttt cttctgttaa agatgtgagc tcttttaaat 2086741 cagcttctga gaaaccggtt gttccgacaa ctggacggac tccgtgctct aatgcaattt 2086801 ttgtatgtac ttttccgatt tcgggcgttg ttaaatcaat caagacatcc ggttgtgttt 2086861 ctgtaaaaca ggcatggata tctgtgtaaa tgaaagcatc tgactcaaca ggcatcacat 2086921 cagataattt ttgctgatcg tatgtatggt ctatggcccc tacaaggtca aaatgtggtg 2086981 ttcgttctgc caatttaaca gcttcctgcc ccattcttcc acgcggtccc gcaatgacta 2087041 atttaattgt ttcgtttgac atcttgatct cctctacttt ccttcttctt ttctggtcca 2087101 gcgatcttta tctcttgtat taaatttatg catgactcgg tcgtgagctt cctctaaaga 2087161 gatatcaaga gagttggcta aacaaaccaa tacaaatagc acatcgccta tttcctcttc 2087221 catgctttta tcatcttcag tcgctttttt tggtttttct ccataacggt gattcacttc 2087281 tctggcaagc tcgcccagtt cttcagtcag cctcgccatc atggccagcg ggctaaaata 2087341 tccttcttta aattggccta tgtaacggtc tacttcagcc tgtatgtctt tcattgtttt 2087401 atcactcact gaacgaaacc tcctatcatc ctcttacatg ttagctaatt cagatacgtt 2087461 tgacaaatgt ttaagcacgt ttgctgtttt ctttttcatc cactataata taaacgctat 2087521 ctaatggaag gaaaaggggt tttgtgtgat gcttggagaa attagattaa aaaacatatt 2087581 ttttatttta atcggagcgg caattttttc atttggcttg gttcatttca atatgcagaa 2087641 caatctggct gagggcggtt ttacaggtat tacacttttg ctttatgccc ttttccacat 2087701 cagcccctct atatcgaacc tggtgttgaa cattccgatt ttttttattg gctggcgttt 2087761 gctcggcagg acaatgtttg tttataccct tgtcggcact gtagccttgt ctttgttcct 2087821 cagcatcttt cagcgatatg aaatccatat gccccttcag cacgacttag cgctcgccgc 2087881 tttatttgcc ggcgtattca tcggagccgg actgggtatt atttttaagt tcggcggtac 2087941 gacaggcggt gttgatatca tcgcacgttt agtgaataag tattttggga ttccgatggg 2088001 cagaacgatg tttgctttcg atgcctgcgt catcattttg tctttgctta cttatctctc 2088061 ctataaagaa gcgatgtata cgctggtagc tgtatttgta gcggcaagat taatcgattt 2088121 tattcaggaa ggcggatacg ctgctaaagg cgctacgatc atctcttcga aaaacgacct 2088181 gattcagaaa aagattcttg aagaaatgga acggggcgtc accattttga aaggacaagg 2088241 ttcctacaca aaagaggata tagatgtact ttattgtgtg gtgccgaaaa atgaattggt 2088301 gatgctgaaa agcgtgatta actccattga tccccatgcc tttgtagcgg taagcgatgt 2088361 tcacgatgtg ctcggagaag gatttacgct tgatgaaaat aaaaatccgc ttccgcgctg 2088421 acatgtaata gaaaaaaggc ggctgaccgc cgcccctcat ccttatttag ggtagtccct 2088481 ttttttcagc ttgttttttt ccgccttgta ctttctgtaa ccgacatagg taagagcagt 2088541 aatgatgata ctgccggttg taatgatcac ccagagtaaa gacggatcgg catcatcctc 2088601 ctccaccctg tcaaacacat ttttcaggtc atgctgaaga agggaaagcc gttcaagctt 2088661 cgtgctctct gtcatttgct gaaattcctc ttgctcaata acatctatat gttttccgac 2088721 tgtttcaagc tgatcctctg atacatcgat tgtaagactg gggtaaatca agtcatataa 2088781 actgataaat tcattccatt tttcatgaaa gcttgtgctt ccattctttt ggacatctcg 2088841 cttcagttca gtaaaagctt ccataatcgg tttttccagt gagccccaaa gcgggtcaga 2088901 ccgattgtca accgcatcca tcagcattct gaactgcgcg gctgctctga gtttttgtgt 2088961 gtctgatgta tcagcttgct ttaaactccg aaccatatca ttatagccca atgtgatttg 2089021 acgaatttgg gctcccgtta gcatggggtc ttgctgtttt ttctcagcgg attttaatgt 2089081 tttttcaaaa tactccaaga cttgaagcgc ctcttcatat ttcgcctgtc gggtcatttg 2089141 aaagactgta tcggataaat cattcaattc ctcgaggctt ccccgctctg cagccttggc 2089201 atttccatta taaaaaataa gtgcaatcaa caaacagatc gtcagctttc gtttcatgca 2089261 ggtccctccc actctctctc cttacagaat atgaagaaag ggacaaggat agaccaacat 2089321 tgtctttaca tcagctcaag cttcgtttgc ttttttgaga ccacaagaaa gtaagcaagc 2089381 gcgattgaaa agatacttag ccaaaatgtt ccgtatccta tttcagtcat ataatcagaa 2089441 agcatagagt attgcggcat catatcaaac aagtagtcaa tgacatcgtt atgcagtgtc 2089501 cagactgcag caattgcaag atgccaaaat gaaaaacgaa aatacggact gtataatacg 2089561 ccttgaactg ccattgcaaa atgcgaagca attagcatgt agccctccca cggcaagtca 2089621 ccagttactg caagcacaag aaaattcata gccaccgccc ataggccata ctttacgagg 2089681 gtaactagcg caagcgcctc taaaagcgga gcattccgtt tcatgagaaa ggcaagcagc 2089741 acaaacagaa agaaaaacgt tgctgtcgga ctgtccggaa caaaaatcag gaaacgggcc 2089801 ggtgtctcca aaagctgcgg caagtaccaa tagtagccgt aaaccgttcc cagaaaatta 2089861 atggctaaga caagaataag catcggccgc tgccctaata catattgaaa ccatttcaca 2089921 tcgaatcaac tctcagtctg taaaaataat atgtccatat aaaaaagctg acgccgggtc 2089981 agcttttgat aataaaagta tatccttcca tttgacaatt cacaatacgt tattttgcgg 2090041 ttgtttcaga aataaatttt gcaagttctt cgagctgctt atcatttcct ttgaacacac 2090101 ccgccggcat tttgcctttc ccttctacag cgattttttt gatttcatcc ggtttcagcc 2090161 cgctgtcaac caatgaaggc ccggccgctc ctccctgaag gttatcccca tggcaagaaa 2090221 tacagccctg ttccttaaaa accttatatc cttctgcatt ggtgtcaatg tcggcttctt 2090281 ttgtaatttt cccctgttct tctgccttgg cccagtcatg agtagcaact gactgccacg 2090341 tcaaaaatac agcagcggaa atggccagaa gcatcatacc gacagcgacc ggacgcttcc 2090401 acggccttct ttctgtccct ctgtctagga atggagccaa aagcagggcc ccaaaagcga 2090461 gacctggcat aatcatggcg ccgaccactg taaagcttcc ggcggcgtat tcatacttca 2090521 acagctggta taagaaaaga aaataccaat ccggcagcgg aatataacca gtatcagtcg 2090581 ggtccgccat ccgctctaaa ggcggctgat gcacaatcgt caaaacgaga aaaccgatga 2090641 gaaagacagc tccaaccatc cattccttta acaagaaatt tggccagaaa gcctctgttt 2090701 tacccggata ctccgaataa tccttcggta tattcggctt tttttcagcc ggtatccttg 2090761 agtcgcctac aaatttcatc cctttgcccc ggtgcatgtc atcccctccc ttttattcgc 2090821 agatcaagag tttaaagcgg tcctgaaatc ccctgcttcc ggatcataat aaaatgtgca 2090881 gccatcagcc cgaacaatgc ggcaggaaga aaaaatacat ggatcgcaaa aaacctagtc 2090941 agcgtttggg cgcctacaat atccggatgc cctgcaagga gcgttttaac ttgcgttccg 2091001 atcaaaggcg tggcttcggc gatctgcagt ccgacttttg ttgcaaacag agccttcata 2091061 tcccaaggaa gcaagtagcc tgtaaagcca agaccgagca taacaaaaaa gatcagcaca 2091121 ccgacaatcc agttcagctc gcgcggtttt ttatacgcgc cttggaaaaa gaccctcagc 2091181 gtatgtaaaa acatcatcac aatgaccagg ctcgcacccc agtggtgcat ccccctgaca 2091241 atctggccga atgccacttc attttgcaaa taatataccg attcccaggc atttttgata 2091301 tcaggcacat aatacatcgt taaaaacatt ccagataata cttggataac ggttacaaaa 2091361 aacgtcagtc ccccaaagca atacacaaac gcagagaaat gatgggcggg attcacatgt 2091421 tccggtactt cgtgatcggc aatatccctc cacatcggtg taatatcaag ccgctcgtct 2091481 acccagtcat aaattttgtt cagcatgtca cccttccccc ttaggctttg cttttccaag 2091541 atacaggaag ccgtctttta cttcttgctc ataatgatca agaggcgcaa gcggcggcgt 2091601 gccagggaca ttggtgccgt ccttttcata gagtccgtaa tggcatggac aaaagaattt 2091661 attcgggttt ttaggatcac tattccagtt caccgtacac cctaaatgct tacaaattgg 2091721 cgaaagtgct acaatttcat ccccgttttt gaagacccag gctgatcttg actcttctga 2091781 ctcataccag gcatcgactt gattaatttt aaaatcaaag cgctgcggct cttttgtcaa 2091841 ctcatcaacg ctgacaacct gaaccatatc ctgcttccct gtcgatttta ataccgggtc 2091901 gagtgcgaag cgaaccatag gcatgagcat actagccgcc ataaaacctc ctacgcctgt 2091961 gagcgtataa ttcaaaaatt gacgtctgga tatatcatgt tttccgccca tctcttctcc 2092021 cccctctaag tcacccctgc aaactgacta aaatagaaaa tattgcaata actctagaca 2092081 ccctcataat atatgaatct ctcagcaagg tcaatatagc caaaatattg tttataagga 2092141 aatgtaagtg tttttataaa gtgctccata actgtaacaa aacgttcaaa atttcagcag 2092201 tgcgttcatc caatattttt ctttttaaag agtcatttaa atgctctaat ggaacagacg 2092261 atgtaacaat cattttgcct aacgcatcct cagctctcca actttcgtca gatgtgagca 2092321 ggacaacatg cggaaattcc gttatcagct cttcccgcaa atccttaagc ccttgaacgg 2092381 ttatttcatt tctatcaaca tatgtataag gcggaagtaa atatacccgt ccctttaact 2092441 gcctttcaag ttcttctgag agaagctgcg taaactcgcc tttctccgcc gccattttaa 2092501 aatggttatt aacccttatg ttaattaatg gtatgacagc ggtatcaatg taatccttag 2092561 cttgtaaata gtccttggca tcagtgattc tccacctcat cgttctcccc ctttacggca 2092621 acaagccttg caattcactg caaggctggt catattatgt gagctgattt aattggcgcg 2092681 ataattgttc aaatgcctct ttatcatgac gatctaacgc gtcgtcaatg tcttttaata 2092741 atttttctct ttggaatgtg gaaatagcgt gctctaaaat ctgttccgcc aatccctgat 2092801 cttttttatt ctcaaaaagg tttttcggaa tatgcgggtt ggactccagc accgccgcat 2092861 attcaggtga gctgtaagcc gaacggaaat taagctggat aaacaaatcc tgctgtttat 2092921 ttaatctaat atcatgaaaa gatttttccg cgtcggtagt catgacattc tctttataga 2092981 accggaacgg aacttcttca acacaatgtg ttgacattat aatgcctctc gggcaaaatt 2093041 cagcctgctc cacaaaatga accttctcca tgagagaatc atggctcatt aagtagttca 2093101 agatccaaac gcactctcgg cgctttaact gataatggtt taaaaaccaa cggataaaat 2093161 cttttttctc attgacagaa acaggggtct gcatgtaatt ccctcctcta tcgttcgtat 2093221 aatctatata cttatatgtt ccacatgaat ggttaatatt cctgcttatc tagaaaattc 2093281 atcctcgatt cgcaaaatcg tttcttcaag ctcttcattg gctccgtcca tttcaagaac 2093341 ctttttcaaa agcggcagcg cttctttttg aagaccttct tctaatagga agcttgcgta 2093401 ttcatataag aaatctctat cctcccggta atgaagatag gcagcctcaa aggattgttt 2093461 tgcttcctcg tattgctcta attcagtata tgcgcttgca agataccaat tgtatttagg 2093521 atcttcttca ccgtagcttc gaacctcttg aataagatca atgatctgat cataatcctc 2093581 ttctttgtga tacacggcaa gaagtgtatg aagcgcctcg acaaagcccg gatcaagcgc 2093641 aagcgcctcc tgaagcagct tcttcccctc ttctgacttc ccgattttca aggccatttt 2093701 ggcggcataa aggaaaagtt ctttgttata ttcatcatat ctgatcccct cttttgccgt 2093761 ttttaatgcc tcttcataca ttccttcagc ttcatagctt ttcgagagcg gcatataaag 2093821 tgaagtataa gatggatcaa gctcctttaa atcagacagc tgcttaatag ctgttttcac 2093881 aagccccgcc tgtaaggctg taaaaccata gccgaaaatc gtattaggat caggattctc 2093941 atcgacagct ttctcatacc atggaatggc atcctcaaat tcacctgagg cacttaacga 2094001 ttctgccagt ctttgatgga cattaacgcc cccgatctca ctctgctcct cagccgttgt 2094061 tttaaaatat tgaaccgctt ttgcataggc tccctgagca aagtaaagtt ctcccagtgc 2094121 aaaatcaata acaggttcat tgtccagaat ggactttgcc tggaaaagct tttgttcact 2094181 gacttcgaat aacccctgca tctgataaag atccgccata agcagcaaac tttccggata 2094241 tgatggatct gtttccggaa tagtctccag cacagcgagg gctttttctt cttcgtcaat 2094301 atctattaaa agttcagcgt agaaattcgt cagttctgtt tcatttggat ataaatcatg 2094361 tagatcacta atcagtgaaa tggctttttc tacatcgccc cactcgtaat aaagctgggc 2094421 tgcaatggct ttatcttcat catgcagctg tttttcagcc ttcgagagcg tgttgaggcc 2094481 tttttctgtt tcacctgctt caactaattt tatggcttct tgaatcaatg tattcaaatc 2094541 ggaccggtcc tttcttttcc tatacaacat caaccataca aaaaaagctt tatttgttcg 2094601 ggttaatctt atcataattc agacgaatgc ccccggcaaa taagatgctt ctgtacggaa 2094661 gggaattatt gagtcttatt agtttaccaa aagatcttga gatagaaaat gaaaaaagga 2094721 agatcgccct ctgtacagta aagcagctct ttgacctgcc ggcttgtaag taaagcacat 2094781 cccccctttt cgtttttcta tccgttctat aagacaagct atgttttttc gcctcgaatt 2094841 atgatctgca taaaaaatcc tgaagtaaaa cttcaggatt ttttcgaaag cttatttaaa 2094901 tgctcgaaga aggttggata agaaacgtga atggcatccg tgtgctcgat ttcaatcggc 2094961 tcctccgtta tacaggaagc aataccaagc atcattccga ttcgatgatc tccgtggctg 2095021 gacactgcag cgccgccttt caacgtttgt ttgccataaa ccttcattcc atctgctgtc 2095081 ggttcaattt cagcacccag cttgcgaagc tcagaaacaa cagtatcaat acggtttgtt 2095141 tctttcactt ttagctctgc cgcgtcctta ataacggtgg ttccttccgc ctgagtcgca 2095201 agaagcgcga tgatagggat ctcatcaatt aaacgcggaa tgatatctcc tccgatttca 2095261 actgccttta gagatgacgt ttctataatc aaatctccat aaggctctgc accgctatca 2095321 gcagatggtt tgatttcaag ttttgccccc atgttttgaa ggacatcaat aatacctgtc 2095381 cgagtcggat ttaaacctac gtttttcaat acaattctgc tgtttggaac catcgcgcca 2095441 gcagcaagga aaaacgcggc tgaagaaatg tctccaggaa caaaaatatc agcagctgtc 2095501 agtttctggc caccagcaat ggaaacactc gtttgatctt cagaaagctt aacgccaaaa 2095561 gcagaaagca tccgctcagt gtggtcccga gatttatggg gctctgttac agttgttgtg 2095621 ccctcagcct gtaatccggc cagcaaaaca gcagatttaa tttgcgcgct tgcaacaggt 2095681 gatacataat caattccttt taatgaagcg ccgctcactg acagcggtgt aaactctccg 2095741 ccggctctgc cgtcgatttt agcccccatt tttttcaaag gctcagtcac acgcttcatt 2095801 gggcgtttcg caatgctctc atctccggct accgcgctgt aaaaaggacg gcccgccaat 2095861 attccgagca tcaggcgaat cgttgtacct gaatttccga catctaaaag gctttctggc 2095921 tctttcaggg catcgattcc ttttccgtga atcacgacat cgctgctgct ttgctcaatg 2095981 tgaacaccca tttttctaaa gcaatcgatc gtgctcagac aatctgctcc cggcagaaag 2096041 tttttaactg ttgttgtgcc tgccgctagc gcgccaaaca taacagagcg gtgagaaatg 2096101 gatttatcac cgggaatatg tatttctcca tgtaaggtct gcaccttatc tcgtttcatt 2096161 ttttccacct caatcagcat aaaaagtttc atattccgcc cgggcttcaa tgcattgttc 2096221 tgcccttttg cggtcgtcat cagactgaaa actgatcctt aaaatcccgt taatatcctc 2096281 tcgtgtttcg ataatgcgga tattcgtgat actgatgcgc tccgcagcta agatcgctgt 2096341 tatctcggat attacacccg gatgatcggg tacatccaca tataaatcat aaaatgcagg 2096401 tatcgctccc ttctgccgaa gcggcagccc gtcgcgataa tccttggctg ttttaaaata 2096461 acgaaataga ttttccgcat cttcttgttc tacatatgta cggatcttgt caatttcacg 2096521 aatccactca tcaaaacggt ctaagatttt atctttatta tgtaataaaa tatcccgcca 2096581 cattgccggg ctgcttgatg caatccttgt aatatctctg aacccgccgg cagcaaaacg 2096641 cttaacaagc ggatacaggt tttccgaatg atgggtttgg tgaacaaggc tagctgctac 2096701 aatatgcgga aaatgactga ttacgcttgt aacgccatca tgctcctctg gcgacatttc 2096761 cacaaaatgg gcattcgtcc ccttcagcag gttttttaac tgttccacag cttgtttgtc 2096821 cgttttctgg cctggcgtta aaatataaaa tgcattttca aacaggaact ccttcgcagc 2096881 ggccactcct gatttatgtg aacccgccat cggatgccct ccgacaaatt gatagcggct 2096941 aggcagcact tgatcagcgt aatcaaccac tttttgcttt gtgcttccta catccgtaat 2097001 caaaagctca tgttcaattc ctgaatgagc cagctcttca agcataacca gtgtttgttc 2097061 aacaggtgtc gcaatgatta ctgtagctgc ctctttcaca ccgctaataa acgaatcagc 2097121 acgatcgtct atcacgccta attttaatgc cgctaccgcc tgttcatcag agatgtcgat 2097181 tccgataatc cgtttgccgg gatgattttt tttgatggct agggcaatcg aaccgcctat 2097241 caatccgaga ccggcgagca atattgtatc tttcatttga ttcatacgtc atcacctggt 2097301 ttatagacta aagaggtgat atttgatcac ctcttataaa atttcagcta aaatggcaag 2097361 tatttcttca ttttgctctt ttgttccgat cgtaatccgg agtgatgtcg ggaaacctaa 2097421 tgcgtttcct gaccggacga tatagccttt ttccagcaga gcctgaaaca gttcatcagc 2097481 aggacgttta aagtcaatta acacaaaatt tgtctgtgaa gggtagcact ttaaaccatg 2097541 agttttcgca aaatcataat actgctgaag gcctgcatta ttttgctcga cacaggaagc 2097601 aataaacgct tgatcatcaa gtgctgcaat cgccgcagcc tggcccagac ggctggtatt 2097661 aaacggctct ctcgccggct caatctggcg aatcaggttc tcgtcagcaa ttccgtatcc 2097721 gactctgagc gctgccagac cgtatgcctt tgaaaatgtg cgcaaaatca tcaaattgga 2097781 atacttgctt aagagcggca cggtttccgg gtaatcctct gctgttacat attcataata 2097841 tgcttcgtca agaacgacaa ggacacgaga aggaacgcgc tccagaaatg cgagtaattc 2097901 tccttcagat gtataagtgc cagtcggatt attcgggctg catatccaaa cgacttgtgt 2097961 ctgttcgtcg atggcttcta acatggcgtc taaatcatgt gagccgtcgg gacgaagtgc 2098021 aatttcacgt acttcagcac cttcaataac cgcattatgt ttatattgcg gaaaagtggg 2098081 ggcagcagta accgtgtttg ttttatcgtt taaaaatgcc cggcagatga tctgtatgat 2098141 ttcatcagaa ccgttgccga aaataagtga tgtttcgctg acattgaggt gcttactgag 2098201 ccttgtccgc aaagcggcgc tatacccgtc cgggtaaagg gctagctgtt gaatctcatg 2098261 atgaagcgcc tcttttgcag cctctgaaca gccgtaagga ttctcgtttg aagcaagctt 2098321 cacaacttta tccaagccat attctgattt cactgcttca atcggctttc caggctgata 2098381 aggcttcagc tgttttaaat gttctttgat acgcaaatca gtcacctcat tttaaactgt 2098441 acaagccgct aaacgccatt gcataatcct caaactcctg cagcgcctga tttctcgttt 2098501 cagcgctgat gagccggtcc tttaattctt ctatttttct gacgagcgca cttcccacta 2098561 cgacaccgtc actaatttca ttcatcttta tgacctgttc acggtttgat ataccgaacc 2098621 ctacagcaac cggaacagtg ctgagattct tcacagtacg aatgaacggg tacacggatg 2098681 aattgaactc attgcggaca ccggtcacac ccagagaaga tacacagtag acgaacccct 2098741 cggcttgttc aataatggtt ttcaaacggc tttcgcttgt cggcgcaact aaagaaatat 2098801 acgtcacctc atggctttta cattcctctt gaaggctgtt gctttcttct aatggcagat 2098861 ccggaacaag cagaccgtca atatgatttt cccgcagtaa agcgaaaaag tattctttgt 2098921 tcaattgtaa cacaggatta taatacgtaa agaggataat cggaatattc actccgtttt 2098981 ttttcatttc tccgcctaat tcgattgcct ttacgatatt cattccttga tcaagcgccc 2099041 gctttgaagc ccgctggatc accggaccgt ctgcaagcgg gtcagagtat gcaacaccaa 2099101 gctccaatgc tgtggcgcct gctttttgga gtgacttcgc cagttcaatc gaaacctcag 2099161 gaactggatc gcccgccgta ataaacggga taaacaattt ttctgatggt tgaagatcca 2099221 atttaaacat gggctttcac ctcttcttcc aatacattca ttaatgtgtt gacatccttg 2099281 tctccccggc ctgataaaca gacgagaatg agttgaccgc gatccattcc tttggcgagt 2099341 ttgaatgctt tcgctaacgc atgggcagat tcgattgccg gcaaaatccc ctctttttct 2099401 gacaaaagct ttaatgcatc caccgcttct tcatcggtta tactgtcata agtgacacgg 2099461 ccgcttttat gcaaatatgc atgctccgga ccgattccag gatagtcgag accggctgaa 2099521 atagagtagg gctcaataat ttgcccgaac tcatcctgaa tgagataagt caatgaaccg 2099581 tgaataaccc ctacggttcc tttcgaaata gtggcggcat gaagaggtgt atcaattcct 2099641 tttcctgctg cttcagcgcc gatcagttca acatcttcat ttaaaaatgc ctgaaacata 2099701 cccatcgcat tgcttcctcc gcctacacat gccactactt tatcaggcat agtgccttca 2099761 atacgtttca actgatcctt cgcttcctct ccgatcattt tttgaaattc acggaccact 2099821 tgcggataag gatgcgggcc gacaactgat ccaatcatat aaaagtgatc ctcacaatgc 2099881 tgaacccagt accggatcgc ctcatttgtg gcatccttca atgttccgtt tccgcttgtt 2099941 acaggcacta cctccgctcc aagaagcttc atgcggaaaa cgttcagaga ctggcgggca 2100001 acatcctctt cacccataaa cacagtacag gaaaagccga atttggctgc aactgttgca 2100061 gcggcaacac catgctggcc ggcaccggtt tcagcaatga ttttcgtttt gcccattttt 2100121 ttagcaagca gcgcttgacc tagcgcatta ttgattttat gagaacctgt atggtttaaa 2100181 tcttctcgtt tcaaatagat tttcgcgccg cctaagtatt cagtgactcg atcagcgtat 2100241 gttaatgcag tcgggcgtcc ggaatagtcc tttaacagct tataatactc ttcacgaaaa 2100301 gcgggatcat ccttgatttg tttaaatgct gtttgtattt catctaacgg ctgcatgagt 2100361 gtttccggaa caaactttcc gccaaaatca ccgtatctgc ctatttcatt cggatatgga 2100421 tacatatcgg ttcatccttt cttctaaaag cctcatcaga ttctgatctt tttgtccgtt 2100481 tttttcaatt ccgctggcaa ggtcaattcc ttctggctgc catttcaata ggcgtgtgat 2100541 gctatccgga ttcacgccgc cagcgataaa gcagcgttta ccaatagccg cctgctgata 2100601 ttccggcaca cattcccaag aaaatgcaac accagttccg cctctagacc cttttacaga 2100661 tgaatcaatc acaaagccgt caacattatc tttaaagcgg gctatttctt gagttgtgtt 2100721 atcttgatgg tgaagcgcct tccatatttc acagcctgtc agcttgcgaa gagcagcagc 2100781 atccgccggt ttttcatcac cgtgaagctg aatgacgtcg agcttcaagc tcttggcaat 2100841 acgtgacatc gtctctattg attcattaac aaaaacacct gcaacctgtt tttcgacacg 2100901 aacttggttc agccattttt tcacatcttc cggagatact tttcgtttgc tttcagcaaa 2100961 aataaatcct aggtaatcag cctgtgattc cgccgcaagc tgcaaatcct ttagtgaccg 2101021 aataccgcaa tattttaatg ccggtttctt cacaacctca ctccctaaac aaagcatgga 2101081 ttgctttacg ctgagaagtt tgtctcatca atgattcacc gataagtaca gctcgcgccc 2101141 catgttcatt gacaaatgtt aaatgttcta aagaaccgat tccgctttcg ctgacaagca 2101201 aggattcttt cggaacgaga gatgcgattt gttctgtctg ctttacagat gtttcaaacg 2101261 tttttaggtt tcgattattt acgccgagaa tgtcgggtgt gaacactttc aatatttgtt 2101321 ctagcgttga tgcatcatga acctccacta acacgtccat ccccttttca cctgcttcaa 2101381 gatataattc atgaaggtgt aagggatcaa gcacctcgcc gattaacaat atggcatccg 2101441 ctccgattct tcttgattcc tctacttgaa gagaatcaat aaaatctttt ctaagtacag 2101501 gaatcgaaac agcacgcttt acgtctgata aatagctgtt ttccccttga aaaaacgggg 2101561 tgtctgttaa aacggaaatc gcatctgcct tcgcagcctc atagtctttt gcaatctgca 2101621 caggtacaaa atcctcttta ataagccctt ttgacggcga tgctttcttc acttcggcaa 2101681 tcaacccgat aaaccgattc gggcttgcca gcgcctcctt aaatgaacgt ttctcgaaag 2101741 gctgctctac cggcagaacc agtgttttca cttcttcttt cttttgtttg atgatttttt 2101801 caagcataga tctcttcctc tttctgcttt agtcgttcaa gctgcgcggc agcgcctccg 2101861 cttgtaatcg tctctaacgc cagctccgtt ccttccttca gtgaggcggt aattcccgcc 2101921 gtgtaaatcg cagcacccgc attaaaagcc gtaatagata aagcggaact gctgctttta 2101981 ttttcaaaaa tattctgaat gagataagcg ctctctttcg gagactgcac ctgtaaatct 2102041 tcaagtctgc catttgtgaa accgaaatct tcgggtgaaa cggtatactc ccggcgctct 2102101 ccgtccttta attcaatcac gtcggtcggt gctgtaattg aaagctcatc taaaccgtca 2102161 cggcttgata caaacataac gtgcttcggc tgaaacgtct ccagtgcgct tgccatcagt 2102221 ccagcttttt caacagaata gaccccaatc acctgacgct tcgcctgtaa aggattgctg 2102281 agcggcccaa gcagattaaa taccgttctg aaacctagct cttttctagt acctgctaca 2102341 tgtttcatag acgaatggta aagcggcgca aaaagaaatc ccatgttgtt tgtttcaatg 2102401 ctgcttttga ccttttcggg agtggtttga atagaaacct ctagctcctc taaaacatca 2102461 gcgcttccgc ttttagaaga gacagagcga ttgccatgct tagcgatttt cgcaccagct 2102521 gccgaggcaa caattgccga ggccgttgag atattaaaag tggaaatacc gtctccccct 2102581 gttccgcatg tatcaacaat atcaggaagt ccatcgactg taagagcgtg tgcccgcatt 2102641 gccttcacaa aacccgcaag ctcttctggc gtctcccccc gatgagcaag aattgacaat 2102701 atccccccca tttcagaagg agtcatttcc gctgccatca tcatattcat cagcgtttca 2102761 gcctcaccgg cagtaagggt ttttccgtca acgcacaatt gtagaaatct gttcatcagc 2102821 tttatcctcc ttgctatgaa acatgtcttc tgcaatatga atcgttttca gcagcgcacc 2102881 ggctttatta cagctttctt cgtattcggc ttccggaaca gaatcagcaa caatgccagc 2102941 acctgcctgt atcgatgcaa caccgttctt tacactcatc gtgcgaatcg taatacaaga 2103001 gtcgatattc ccgtcaaacc caatgtaggc aatacaccct ccgtatgtct ctctcggtgt 2103061 tggctcgagt tcttgcaaaa gctgcatggc acggattttg ggtgcgcctg ttaaagtccc 2103121 cgccgggaaa gcagacatca gtgcatcgac aggatgaacc ccttttttca atcggcctgt 2103181 aaccaccgag ataatgtgca tgacatgtga aaaggaaaca atttttgtga actccggcac 2103241 agaaacagaa ccatactctg ctactctgcc gatatcgttt cgggcaagat caacgagcat 2103301 gtaatgctcc gctttttctt tttcatcctt catgagctca accttcagtc tctcatcttc 2103361 agctttgtct gcaccgcgtt ttctcgtacc ggcaatcgga tggatttcta agtgcccgtc 2103421 ttgaacgtgt attaaccgtt ccggagagct gccgactatt tctctgtcta gcagtttcat 2103481 ataatacata tacggcgaag gattgacgat cctaagcact cggtataact caaaagcatc 2103541 tgcttttatc ggcacctcaa atttttgtga taaaacaccc tggaagatat cgcctgcttt 2103601 tatatagctt ttgatttttt ctacatcagc cataaaagcc gatttttcat aattagaaga 2103661 tactgtctca aagctgggtg tcttgtatga atcagcagaa agaaacagct cttttatgtt 2103721 tttttggtcc atcatttttt caatgagatt ttgaagctcc agatgatttt gatggaatac 2103781 atccattttt tcgttttttg tttcctctcc agtgagcctt gcatattgga taaagtggac 2103841 gtttttggtt tcatgatcat acgcaattaa tgtccggcaa acaaacagca tacacttttc 2103901 catgtctgtt tctttggtat gcgaaggaac agaaggctca atcagcggga tcatatcata 2103961 gcttaagtac ccgacagctc cgccgacaaa aggaatgcca agctcaggtg ttttgatttt 2104021 gtatgtggta ttcatccagt tcagcacttc ttttagttca tttcctgtgt aaagagattt 2104081 gctgtcctga tcagcggccg aaaaacggcc ctgctcttct ttaattgtga gaaatggatt 2104141 caggccgata aacgaatatc tggaccaagt ggatgtatcg tccttgcttt caagaagata 2104201 cgtaatctcc ctgtcaagct tctctatcat ttgaatgggt gtcagtgtat cgactgtgaa 2104261 ggtctccaca atcggtatcg tgtggtggga caagctgtcc tctaaaaatg cggaaatgtt 2104321 tgattggaaa ttcattgctc tcactcctta tggcaaggag aatgagaaga tggcatgaga 2104381 ggataaaata ctatataaca aataaaccca aaagaaagac ttcttttggg tagaataaac 2104441 ataatgtctc agctcaacta aactcattct ctgctaccct attctctaac tcaactcatt 2104501 ctaattgctt tatacacact cttgtgtatt tctaagctgt tcttatcgta ttacaattca 2104561 gtattttttg tcaatgataa atcgggcctc aatacgacaa ctttttctaa atatacatgt 2104621 ctgatctgat cctgagggac atctgtctgg accgtcatca tgactcttat gcactttttc 2104681 agaccgcctg ttacgtccat ttcctgcata catgttaccg gtacatactg ccatcctgaa 2104741 agctcgcgaa cagcttttgc cgggaaaaca gcgtgcaaat caggtgtagc cgacagaagc 2104801 atttgaacaa catcttccgg ttttgtatga ttttcttcta tgattttctc taacagctgt 2104861 ttagtttttt gtaaaatttc ttcttcagta tcccgttcaa ctgtagttgc tccgcgaatt 2104921 ccgcgaatca tcatgatgtc tcctccaatc gccatttgtt cagccagctc tcaagttcat 2104981 ttctggaaaa tgtatgatca gcaactttcc ctaattcgtt gagcacaata aactgaatct 2105041 tcccgccacg ggttttctta tcattcatca tacggttcaa gagaaccgaa gtttccgtct 2105101 cttttctgat ttgacttgga taacccaggc tttttagcca gctgaccaaa cgttttctgt 2105161 ccatttcaca gcctacagtc ttttcgctta tatataaagc aaactgcatt ccgagggcta 2105221 cggcatcacc gtgagtgatc tgcccatatc catattccgc ctcaacggca tggccgagcg 2105281 tatgcccaaa gtttaagtaa gctcttatcc cctcttcttt ttcatcctgc tgaacgacag 2105341 acgctttaat tgaaatgcct ttaaaaatca tgtcattcag ctgatcatta gtgatatcac 2105401 gcagtgagtg gatattcagc agctcctcca gaaacgctct gtcatagata aaagcgtgtt 2105461 taatcacttc tgccattccg gacctaagct ctttttcagg cagagaacgc aggaaatctg 2105521 tatcatagag cacggctttc ggctgataaa acgcaccgat tagatttttt ccaagcggat 2105581 ggttcacggc tacttttcct ccgactgcgc tgtcatgcgc caagagcgtc gtaggcattt 2105641 ggatgaaatc aatgccgcgc ataaaagtgg cagccacaaa accggcaaga tcccctacaa 2105701 caccgccacc gaatgcgatg atgcatgagg agcgatccat atgaaaacga atcgcttcac 2105761 tctgcaattt tgtgtacatg tccatggatt ttgcctgctc tccactcggt accgtcactt 2105821 ttttcacagg ccatttttct tgcagcaaat ggagcatttc atcaccatac aggcggtcca 2105881 cttcttcatc cgtgacaaac ataatccttg ttaaaggcct gtttaaagag gttaatagtt 2105941 cgcaagcctt ttttctgata ccttgtccga taaaaacagg atatgacgag gaagcagttt 2106001 gaacatgcag tgtcttcatt aaaattccct cgacagtttt ctcatattct ccacattttc 2106061 tctaatgcgg tcaatttgat ctaatccgaa ttgttcaacg actgcgttcg caatttccca 2106121 agcgacagcc gcttcagcga ctacacttgc cgcaggaaca gcacagctgt ctgaacgttc 2106181 aatgctggca gaaaacggtt ctttcgtttc aatatcgaca cttttcagcg gtttatacaa 2106241 agtcggaatc ggcttcatga ctccgcggac aacaatcggc atccctgtcg tcatgccgcc 2106301 ttccagtccg ccaagtctgt tagtagcacg ggtgtatcct ttttcctcgt cccaaatgat 2106361 ctcgtcatgg acttcgcttc catttcgccc tgctgcctca aatccgatgc cgaattccac 2106421 acctttaaat gcgttaattg acagaacagc ggcagcaagc ttgctatcca gcttgcggtc 2106481 ataatggaca tagctgccca cgcctaccgg cattccctcg acaatgactt ctactattcc 2106541 gccgatggaa tctccgtttg cctttgcttc atcaatggca gccatcattt ttttgcctgc 2106601 ctcttcatcg tagcatctga caggagactc ttccgttaca cgctgcaagt cttcaattga 2106661 cgtatactct gttttttcag ctttaacagc gccaatttgc aacacgtggc ccgccacctt 2106721 aatgccaagc tcagaaagaa tctttttagc tacagcccct gccgccactc tgacagttgt 2106781 ttcccttgct gaagaacgct caagcacatt tctcatatca cgatgattat atttaattgc 2106841 accgtttaag tcagcgtgcc caggtctcgg tctggaaatc tggcgcttca tttccttttc 2106901 ttcatcttct gtaatcggag cggcgcccat gatttttgtc caatgcttcc aatcgttatt 2106961 ttcaactacg agagcaattg gcgaaccgag tgtacgtgca tggcgcaccc cgctcataat 2107021 tttggcctgg tctttttcga tctgcatgcg gcggccgcgg ccgtgtcctt tttggcgtct 2107081 ggcaagctca aaattgatat cttcctccgt tatgtaaagc ccggcaggta caccctcaat 2107141 aatggttgtc agttgggggc cgtgtgattc tccggctgtt aaatatctca tgacttcttc 2107201 tcccttcatc gcattaacgc ttttaagtaa gactactata acatattttt cagcaaaaag 2107261 tcagtctatc ttttttgata aaagaatgta tcggctggga ctaggccaaa tttctcggga 2107321 ttgaagattt gctcggtgct gccgacaaaa agaactccat tcttcttcaa gctatgtgcc 2107381 atttttaaat acagctcttc cttcgcgctt tctgtaaaat aaataaatac attgcggcac 2107441 acgattaagt caaagtcttg ttcataacga tccgccagca aattgtgctt tttgaatgta 2107501 atattctttt tgatttccgt tttcacttca taacttctat ttgcgttttg cgtaaaataa 2107561 cgatctttca cagatagcgg cacttcctgt aaagaccgct cctgataaac gccttttttc 2107621 gctttttcca atgctttttc atcaatatcc gtcgctaaaa tctgatagcc cggaagacct 2107681 ttttgctggt ccaaaagcat ggcaagcgtg tatggctcct cccccgttga gcaggcggca 2107741 ctccaaattt ttaaaggcct agaggtcttg attaacggca gaattgcagt ctcaagaact 2107801 tcccatcttt tataattacg ataaaattct gaaacattga tcgtcattct gtccaatgtt 2107861 tcatttaaga gagcttgatc cttttccaat gccgcagcaa agtccttaaa gctttggaac 2107921 ccctttttct cataaagtga cgttagcctt ctcttcattt gtgcttcttt atatagtgtt 2107981 aaatcgactc cggttaattg tttccatttc gttgtaaata cgctgtatgt atccatctct 2108041 actctcccag tctcgctgtc tttttgtcct agtatagctt gttttatcag gaaattgtat 2108101 tgtttcaata aaaaaatcag cttttcagct gattttagat cgttgggaaa ggcagaggtc 2108161 tgatgcacac tgccattcaa ccctttattc actttaatgt aaacctttac aaaacagaac 2108221 aaaaaccggc ggcgttatat gttgccggct ctgttgctta ttttcacaat gattaataga 2108281 tccagcctgc cataagctgc tgatatgata ctaattcttc attcttaaag aaaatgttaa 2108341 tctcgcgttc tgcactttcg agagaatcag agccgtggat gatgtttttt ccgacaaaca 2108401 tgccataatc cccacgaatc gtaccaggta aagcttcttt agggtttgtt ttcccgatca 2108461 gctgtctcgt cacttcaatg acattttcgc cttcccacac cattgcgaat acaggtcctg 2108521 aagtaataaa ctcaacgagc tctccgaaga aaggcttacc ttgatgttcg gcgtagtgtt 2108581 tctcagccat ttgttcagtc actctcatta acttggcgcc agctaattgt aagcccttac 2108641 gttcgaatct agataaaatg tccccaatga gctgacgttg gacaccgtct ggtttcacca 2108701 tgataaaagt cttttccatc atattctcca ccccatcatt atgtatgtat aggctttcac 2108761 actgcacacc gaaatcgtaa catctttctg ataattaatc aatccggggc ggagaaattt 2108821 cttaatatct acaaaaatta aaattttctt ttaccgatat attttgcgat ggctgcaaga 2108881 gacgagcgtg cgcgccctcg aggaagcgtg tttaatttct gaaaagcttt ctgcagatac 2108941 atttcgctta ctgccataga tgcttcaatt gcatctgttt ttttgatttc ttcaatgatt 2109001 ggttcaagct gttcctgcgt tgtctcactg ttaatcaatt taagctggtt ttttaatgca 2109061 ggatttttca gggcatacag cactggcaat gtgacgtttc cttgaagcaa atctcctcct 2109121 acgggtttac ccagctcttc ctcagttgaa gtaaaatcaa gaatatcatc aataatctga 2109181 taagacatgc cgacgtaata cccaaaccag tacaatgcct tatgaatctt ctcatcagct 2109241 ccagacgcaa tggcaccaag ctggcagctg accgcgatca agagagctgt ttttcttttg 2109301 atacggcgga gatacgttct gagattttgt tccatgttgt atttgtcttt gatctgctca 2109361 atttccccta gacaaacttc aacgatcgtc tgtgacaaaa tcctatgggc tttcggttcg 2109421 ttaattctcg tcatcatttc aagagatccc gcaagcatat aatcgcctgt gtacatcgca 2109481 atacgattgt cccactttgc tttgattgtc ggttttcctc ggcgaagctc tgcatcatca 2109541 atgacatcat catgaaccaa agatgccatg tgaatcattt ccagagtgac ggcgacatat 2109601 ttaatcttat taatatcata atcgccaaac atgccagaaa gcagcacgaa aacaggccga 2109661 atacgtttcc ctccggcctg cagcaggtga agacctgcct cgcttaaaag cgggtaatcg 2109721 gaacgtacgg tttgttcaag ttctctttcg attacatcaa tatcgtcatt taaaaaagag 2109781 taggccattt taaatttcat atcattcacc caaacatctg tgttttcatt tccatccgat 2109841 atgcgtggca gcgactccgc cagtaaacga atgatattta acatttttca ggcccgcctc 2109901 ttcaaacagg cctgccagtt ccttcattcc agggaaatct ctggctgatt cttgaagcca 2109961 agaatattct ttatagctct tcgcaaacag tttcccgaaa aacggcataa tatacttaaa 2110021 gtacataaag taagcctgtc tgaatccgaa catttccggc tgggacgttt ccagacatac 2110081 cacctgcccg cccggcttca ctacacgtct catctctttc agtacagtca agtaatcagg 2110141 gacattgcgg agtccgaagc caatggtgac ataatcaaat gtatcatcat caaaaggaag 2110201 ctccatcgca tttccgtgca gcagttcaat ttggctgaat ccgccgtctt ttactttctg 2110261 ctcgccgaca ctcagcatat tttcactgaa atccaagccc ttgatctcgc cgcttttgcc 2110321 tgccgctttt gcaagagcga tcgtccagtc agccgttccg cagcagacat caagtgcttt 2110381 tgcgccttcc tttacattca tgatgcgcat cgttttgtcg cgccattttt tatgctgctg 2110441 aaaactgatg acagagttca tttggtcata atttttatat attttttcaa atactccgtg 2110501 tacgcgctgt tcttttgagt cctgcataat ggtttaccct tcttccactt tctgatgata 2110561 ggtttgatct tggctgattg tcttcagacg gtttattaaa atgttctgaa taggtgaatt 2110621 tagaggcaga agtgactcaa tgctgttttt cgctttttta aaacaatctt ctaatatctc 2110681 ttcttttgtt tttcccagct gtataaaact gccgatcaca tccagaaatg catcatttcc 2110741 gttcataagc cgcttaaata caaaaaaatc actcgacagc tttttccagc gcgggaggtt 2110801 gaagtgttcc gccacacgat ggaataaagc tgattcaacg atgccgacac tttcgaaaaa 2110861 atcgttttcg tccttgaaag aacggtcata cagacgaatt ttatgttcgt tgatttcttt 2110921 aatggctgta gcaagcgtcc gaatcatgta gatatccttc atttcagata gtaaagagta 2110981 gtacagcccg ctgaaataat cgcccgcgag aacagtcaat tggcggtttt tgttttcgtc 2111041 tcgttttatg actctagctg tcgtcacttc atcatgggta tcaagggcgc tttgtacaag 2111101 catcgctgtt acaatataat tttctctgtc gttgtttttt atgtcggctt cttcaaataa 2111161 agcatgaaaa agaagaagct tatcctcatc aattttcggc gcagaaatat gcttcgctaa 2111221 ataaggatga gacagctttt gttttaattt cgtgttcaga ttggctaaag ttccgtagat 2111281 gtcttgcaaa aatatcaccc ttgtccccaa attcacattt atttcttaat ctatgtatga 2111341 gttttatctt ttcattcgct tacgcaggta tcattatagc ataaaaaaaa gaaattggct 2111401 gtatcctccc gctgtttgcg agcatttgct tttaacagcg gggacagcca gcttattttt 2111461 tttcgctttt catttctccg tacgcggttt gaatcagtgc ctctcctctg actttaatgg 2111521 cagaagtatg ctctgtaaac tgagcgatga tcacttctcc cttgtcgagt ttttcggaat 2111581 ggtgaaactt tgtgtctgtt cctcttgtca ggccgatcac attcactccg tcctcaacgg 2111641 ctttaatgac gacaaaatca cttgaatgct tttggttcat ttatagcacc ctctatcttt 2111701 attagtcctg gcgtttaata tgttccaata cttctgcacg ggcagcggca tcatctttaa 2111761 aaacgcctct gactgctgaa gtcacagttt tcgcacccgg ttttcttaca ccgcgcatcg 2111821 tcatgcacat gtgttccgct tcaaccacta ccattacgcc atgcggatca agcgtttcta 2111881 cgatgctttc tgcaattgta gaagtgatgc gttcctgaag ctgcgggcgc tttgcaacgg 2111941 cttcaacggc acgtgccagt ttgctgagtc ctgtgacctt tccgcctcgc gggatatatg 2112001 caacatgtgc ttttccataa aagggaacaa ggtgatgctc acacatagaa tgaaacgcta 2112061 tatcttttac aagaacaagc tcctcatggt tttcaccgaa gatagtctgg aaatgttctt 2112121 ttggatcttc attcaagccg gagaatactt cggcatacat ctttgcgact cttttcggag 2112181 tatcaagaag cccttctcta ttcgggtctt ctccgatcgc ttctaaaatt tgacgaacag 2112241 cttgttcgat ttgctcttta ttaacttctt tcatgttcta tgtcctccac caatgaatac 2112301 atttaatttc gattctagca catatgcccc gctaaaagca aagtgaatgc cctgtcagga 2112361 agcccatgct cttgaaatat gaaaagcccc ttagaaaggg gcttttctgt gaagaaataa 2112421 agtgtatgta agctagatgc atacacgatc tatattcaca attattttcc ggcaactgcg 2112481 tctttaagcg ctttacctgg tttgaaagca ggtactttgc ttgctggaat ttcgatttct 2112541 tcacctgttt gaggattgcg tcctttacgt gcagaacgtt cacgcacctc gaagttacca 2112601 aaaccgatca gttggatttt atcaccgttt ttaagtgcat ctaagatcgt atcaaaaaca 2112661 gagtcaactg cttttgtagc gtctttttta gacaattcgc ttgcttctgc aaccgcattg 2112721 ataagttctg ttttgttcat gcctttcacc tcctcccaaa aggatacatt cagttcgttt 2112781 attatcattt cttcacagtt cagtctgatt ctaaacctgt ctcagaaaaa aatgagagca 2112841 agtaagagaa agacaattaa acggcttttt aagaaaaact gcactctgag gaatgtttgt 2112901 ccaacaaagt gaagaatttc tgtatgtaga gtaacacata taaaaagcca tatcaagcat 2112961 tttaaagcgt caatcccttg ctcgtcaagg atttaaggtg atttaccgaa cgaatattcc 2113021 tttttttcct tttttcatcc tattccttga tccttttcca ttattaagag caaagaaaaa 2113081 agacctccca ttctataaag aggtctaccg gtattacagg atgatggcga ttaagccgcc 2113141 agagccttcg tttatgattc tttctaatgt ttcttttaat ttataccgtg cgttttcagg 2113201 catcaatgac agctttgcct gaatcccttc tctcacaatt gagctcagcg accttccgaa 2113261 gatatcggaa ttccagatgg agagcggatc atcctcaaag tcctgcatta aatagcgtac 2113321 aagctcttca ctttgttttt ccgttccgat aatcggggcg aattcgcttt cgacatctac 2113381 tttgatcata tggatcgacg gagcgacagc tttcagcctc acaccgaatc gcgagccctg 2113441 ccttataatt tccggctcat cgagactcat atcagctaaa gcaggcgctg caatgccgta 2113501 tcccgtctgt ttgaccattt ttaaggcatc agacacttga tcatattctg ttttcgcatg 2113561 ggcgaagtct tgcatgagct caagcagatg gtctcttcct ctgatttcga cgcccacaac 2113621 ttcttttagg atttgatcat atagatgatc aggcgcgtac aaatcaattt ctgccacccc 2113681 ttggcccagc tcaattccgg ctaatccggc actttcaatg aattcaaact cgctgaattg 2113741 gccgacaacc ctgtctacgt cccggagccg tttaatatcc ttaaccgttt ccttcacgga 2113801 ctcctgatag ctttcacgca accaatggtt ttctttcagc accattaccc agcttgggag 2113861 attgacattc acttctagca ccggaaactc gtagagggcc tctctgagca cactcagcac 2113921 atctgattcc cgcatgctct ctacactcat tgccaatacc gggatatcat atttttcgct 2113981 taaatcctgg cgcatggctt ccgtttccgg gtgatacggc ctgactgagt tgatgaccat 2114041 aataaaaggt ttgccaacct ctttcagctc ttcaatgact ctttcttcag cctctatata 2114101 gtcacttctg gcgatatctc caatggtgcc gtctgtcgta atgacaactc cgatggtcga 2114161 gtgttcttga atgacttttc gtgtgccgat ttcagcagcc tcatgaaatg ggatcggttc 2114221 ttcgtaccaa ggcgtattga tcatccgcgg cccgttttca tcttcatatc ctttagcgcc 2114281 gggcactgtg taacctacac aatctactaa tcttatattc acatcgagtc cgtctgacac 2114341 atgaacagac atcgcctgat tcggaacaaa tttaggctct gtagtcataa tggttttgcc 2114401 ggctgcgctc tgcggcagtt catcctgcgc tcgggcccgg tctgcttcgt tactgatatt 2114461 cgggagcacc acaagctcca taaatttttt aatgaacgtg gattttcctg tacggacagc 2114521 acctacgact cctaagtata tatcgcctcc tgttcgttca gcgatatcct tgaaaatatc 2114581 gaccttttcc aagtgatccc ctcccggact tcctatcctt ttcaatttta ttaagctctt 2114641 tcaatcaaac acaggacact atatgtgtat gacgttgtcc tatttgaata tgacatcttt 2114701 agaaaatttc tcatcctcaa tctattaata taaaaaaacc tttctcccta tttgtatgca 2114761 agggagaaag gttcattcct ttttcatatc attttctaaa aaaacaggtt cctgtttgtc 2114821 atttaccgta tattttacag aaaacgcggg gacaaagggg gtttcatgcc aaatcatatc 2114881 ctggatttca gtcccgggtt taaacgtttt tttgcttttt ttgaggcaag aagccagctc 2114941 agtccggtaa tcggcatata tttctccgtc tccgtcaatc ataagcggca aggaattccc 2115001 tgagattggg cttgtcactg taagagagct gccatcccca agcttcttct catcgagtgt 2115061 aaataaatca cgagatagca catccttgta aggcggatat tgatgctcct gacgatacat 2115121 ttggatgcgc aatttcacat cgcgaatttt ttctgccatc tttagatcaa ttaatttaac 2115181 agtcggatcg ttctctacgt caacaagcac gtattgatag tctcccccgc tttcaaatgc 2115241 cgtacttgga ggttcagcta tgtatcttgg cgctaaccgg ttaaagtcta tcggatattt 2115301 ttgatatagc ggtgtcgaca tatctttggt ttgaatagga agcagccctc catttgcctt 2115361 ttgaaattca tcaacagcag attgaacctg ctttagctgg tcttgataag gaatggcatg 2115421 cacactgctt ttccgttcat ttggatataa acatccggat aaaaacacga ctgccgcaaa 2115481 aatgattgcg cacttcagtt tacccataca gcacttcctt ttacagcttt attcattgac 2115541 agggccgcta aaaaccacga caaacacaat aattccagat atgagcatac acatgtatgc 2115601 gaatgatgaa atcgcaatct tcaaaaaacg gttttggcac ttaaagcggc ttaaatagat 2115661 ggaagctaca gccagaaaca tcagacccat ggaccctaga gcaaaccaca ttttcatcaa 2115721 tgccagattc aatgacgtgc gcctccccga tatgtaagat ataagcgtta tattatattt 2115781 taatatacag cgccggaaaa gatcaaccag attttccatc cattgataga acaaaaaaac 2115841 tgaagcaaag agggggacct tcgcttcagt caacttgact atattcacct gcacgtttaa 2115901 gaaacactct cttggacttc gatgctatag tatgcgactt ggcatacaga tgcatcctct 2115961 attgcctaaa tcggcaaaat gtttcaggag atcccaagac ttgggtgttc ttctgttttt 2116021 cgggctttcg ttcaattaag atatgcgatt caccatttga ttgacacttt tacttcactt 2116081 gattttcaaa cgtatttacc aaatcctcca tctcgtgggt tttccctctc gccattaaag 2116141 attcaacagc ggtttccact ttttgtccgt tgaataggac ctgatggaga gcttctgtaa 2116201 tcggcatttt aacatcatat ttcttcgaaa gctgataagc cgctttcgtc gtgcggacgc 2116261 cttcgactac cattcccatc tcttcaagaa catcttcaag cttgtaccct tttccgagca 2116321 aattgcccgc acgccagttt ctggaatgaa cacttgtgca cgtcacaatc agatcgccta 2116381 ctcctgtcaa tccagagaac gtcaagggat ttccgcccat tttcgttccg agtctcgcga 2116441 tttcggcaag tccgcgtgta atcaaagcag ctttggcatt gtcaccgtac cctaaaccat 2116501 ctgtaattcc tgcagcaagg gcaataatat tttttaaagc ccctccgatt tcaactccga 2116561 taatgtcagg atttgtgtac acccgaaaat tgtgattaat aaatagatcc tgcacctctt 2116621 ctgctgccct catgctcttt gaagatgcag taacagttgt ggggtgccgc agccctactt 2116681 cttccgcatg actcgggccg gaaaggacaa cgatatcttt tctgacatca ctcgggagct 2116741 caatttccat aatttcagaa atgcgcagaa gtgaatctgg ctcaataccc ttgctgacat 2116801 gaacaaagac tgcctttttc gttataaaag ggacagcctg tctcagcact tcccgaattg 2116861 cttttgtcgg gaccgcaacg ataatgacat ctgcgtctga aacagcctct ttcatatctg 2116921 ttgttccttt aatggatgta gacagcttaa cattcggcaa ataatctttg ttttcatgca 2116981 actcattaat ttgatgaatt aaatctgcac ggtgagccca cacacacact tcatttccat 2117041 tatcagttag aactaaagcc agtgctgttc cccaactccc cgctccaagc attgtgactt 2117101 ttttcatgtt tgattcacac ctttttattt tctagctctt gcaaatattt tgattggtgt 2117161 cccctcaaaa ccgaacgcgt ctctgattcg gttttctaaa aaccgttcgt atgaaaaatg 2117221 catcagttcc ggatcgttta caaacacaac gaagcttggc ggctttaccg acacttgagt 2117281 cgcatagtaa attttcaaac gagaaccgtt atgagtcggt gtcggattca ttgccacagc 2117341 gtccatgatg acatcattta agacgtttgt ttgaactcga agtgaatgat tttcactagc 2117401 tttgataatc gcaggcatca gagtatggat ccgttttttc gttaaggcag acataaatag 2117461 gattggcgca taatccagaa attgaaaatg atcgcgaata ttttcttcaa attctttcat 2117521 cgtgctctca tctttgtcaa cagcatccca tttgtttacg acgatgacga cggccttgcc 2117581 cgcttcgtgt gcataaccgg cgatacgctt gtcctgttca ataatgcctt cttcgccatc 2117641 cagcacaacc gccacgactt ctgagcggtc aatcgctttt agcgcccgca gtacactata 2117701 cttctcagtc gtttcataga ctttcccttt ttttcgcata cctgcagtat cgacaatgac 2117761 aaactcctgc tggttgtaag taaatgacgt atcaacagca tctcttgtcg ttccagccac 2117821 gttgctgaca ataacgcgtt cttcgccgag catcgcattc acaagtgaag actttccgac 2117881 atttggacgt ccgatcagac agaattgaat aacttcttca ttgtatttcg tttcaggaat 2117941 gtttttaaaa tgctctgcaa cggcatccag taaatcaccc agtccgagtc cgtgtgttcc 2118001 cgaaattgga tacggctcgc caaagcctag cgaataaaaa tcataaatat tcgctctcat 2118061 ttctgtgtta tccagtttat taaccgctaa aacaacaggc ttttttgtgc ggtacaaaat 2118121 tttcgccact tcttcatcag cagctgtcac gccttcacgg ccgttcacca taaaaataat 2118181 cacgtccgct tcatccatgg cgatttcagc ttgctggcga atctgcgcta aaaacggctc 2118241 atcaccgata tcaataccgc ccgtatcaat caaattaaaa tcataattca gccattcagc 2118301 cgagctgtat atccgatccc ttgtcacgcc aggggtatct tctactattg aaattctttc 2118361 tcccgcaatc cggttaaaga ttgtggattt tcctacattt ggtctcccga caatggctac 2118421 gacaggttta cccatagtac ccttcctttc aatccagccg ctttcatttt tacataaatt 2118481 ttcaaccggt tattaaaatc atttcattca cttttatgaa aagaaaccct tcagaggaag 2118541 ggcttaactc atttattata tcagttttta ctgggatcac aactattctt aaaaatgttt 2118601 cacgatcaaa tacacgtcat ctccgattct gtgagctatt ccatcaagga tcgcctcaag 2118661 atttttagcg aaaagctcca tctccttttg gtcattgcaa aaaaagacag gtgctccccc 2118721 tgcaacccga tttcgatttg tcgtgattac agacaaaatc actttcgtaa gagattcact 2118781 catcctatca ccttatcctg attcttgata aattcagtcg gcattctaat cgcattttcc 2118841 agggttggaa cattgctaat aatttgaaca gccgtttcgg gatggtgaat ttgcgggaga 2118901 acaaatactg ccactctccc atcatttaaa tcccgttttg caattggtgt caaagatggc 2118961 tctcctgaat cccgataaac cccgagcaca ttggaaacat caaataaaat ggcctgacgc 2119021 tgccctaaat ttgctatcgt cgctgctgaa ttaaagtttt tcggcgtcaa aataaagccc 2119081 atgccatgct ttaaaatcag ttcctgtttc tctggaagcc cgatattcat catataaata 2119141 ttatcaacaa acagtcccgg accgtcaaag cgcggcttta tgtactcgat atctacaata 2119201 tccttcaaca cactgcccga cataaacttc atggccagta aaaaacaaac gacagccgct 2119261 atgactgcag cccagatgga taaaaacaca tacgcagagg ttgtcaaaag cgctgtaaag 2119321 atcacaatat aatttctgct ttcaaacgca atggcaatcc cctcaatata tgtgcttccc 2119381 cttgagacaa gttcatacga atccatttgc gtcaatgtgt tccgctccat gtttcggaca 2119441 tctctaaatt gcgtcgctgc caatgttaaa aatgtgatgg ccgtaaattc ctcctgcaaa 2119501 agcgccggca taataattgc acctaaacca gccgctatca accccagtgc gatgtgaatc 2119561 actttcccat gaacataggt cggatactgg cggtaatccg ttttcagcat ataaagcctt 2119621 gtcgcaattc cggcaatgac cccagcaata atcggataga tgtaatcact catgacattt 2119681 tggtagctcc tttgtttgat cttttgcttt tctgaccaat ctggcttgcg aggtgttcgt 2119741 atttagatat gccaaacagc aatatcatcc ccgcagaaca cgcattcagc cattgaaagc 2119801 cgccgacagc catagccccg gccaacttct ggatcacaaa tgaatacacc agttcgcctt 2119861 ggcacatccc taggacaaat aagacaagct gcttctcaaa attcctttca acagaagctg 2119921 ttaaaagcac tattaatata acagcagccc actcaggttt tatgatgaac caaaccgggt 2119981 catataatgc aaaaagataa acaaacgcat acgcggcaac aagcgtcaga tagaccatga 2120041 tgtaacgaaa acgatacatt cccaaatacc cggcatagac acatccgcaa acgaaaaaca 2120101 tcaaatatgc agcattcagg gaaaaatata aagcgatgtc atgtatgctt agaataatat 2120161 tagttaaaat aaagacagag acggcaattc gtcttttcgt cttttcaaaa ataaatgttg 2120221 tcagaaccca cagaaaccac attgaccaat agtaataaaa ttgttccatt ttacttcctc 2120281 catattccca gtatggagtt caagcacatt ttttaaacaa tcgatctcac attaaggagt 2120341 atgatcatgg gaaaagacag acaagagaaa aaactcaaag cttcaggcag agtcgaatca 2120401 gatcgcgacc agtccattca ctatgacgga gcgacaagcc ttgaacaaaa cggaagattc 2120461 aaaaagcgaa aatcataata caaaaagccc aaaccacata tggttttggg cttttatcat 2120521 ttatcgcaca ctatagcttg atgtattgac ccctctctct gtgagccaat gatgggtttc 2120581 acctttgatc acaaggggcg ccttttgtaa atcggcaatt gttctggcac ccagcacggt 2120641 cataatcaac tttaattcct caaggatcag ctgaatctcc tcaagcagtc cttcctcacc 2120701 gctgtcagtc agcgctttta aaaaatgccc tgccattccg gtgcaagagg cccccagcgc 2120761 aattgccttt gccacgtcaa gcgcatcttg cagaccgcca gaggcgatca tggtgcttgc 2120821 aggaaactca gagcggattt ccgccaaact tgcagctgtc gaaatgcccc acgaattaaa 2120881 aaaggagatt tgccgctgtc ttcggagatt ttcgattttc gagaaatttg ttcccccgta 2120941 accgccaatg tcaacagctg cagcaccagc ttcatacagc tttcctgctg atgctttgct 2121001 cataccgaag ccgacttctt tcacaatgac cggtacactg acccggctgc aaatttgttc 2121061 aatgcgtttc aatgcgccgc taaagcttct gtccccttca ggcatcacaa tttcctgaat 2121121 cacattgagg tggatctgca gtgcgtttgc tccaatcatc tcaacggctt cctttgcctg 2121181 agcagccgtt gcctcgcttc ccaggttggc aaaaatcagc ccgtttgggt tttcctttcg 2121241 aacaatttca taggaaagac gctctgatgg atcttttaat gctgacattt gcgatcccac 2121301 agcaagggga attccagcct gagaagccgc tcgcgcaagc gatttattaa tctcatatgt 2121361 aagttttccg ccgccgccag tcattgcatt gataaaaatc ggcgaactgc ttgaaagttc 2121421 gccgattttt gtggaaatat ctacttgttc taatgcaaga tcgggcagac tgacgtgaac 2121481 aaacgtaata tcatcaagac ctgtttcccg cttctggccg atggacaagg catgattgat 2121541 gtgttgtctt tttcgttctg ctcgagtcac gtttatcacc aattatttta gtttattcag 2121601 cttatctccg atcagatctc caagctggaa gccagtgctt gtttcttcct tcgcttgata 2121661 ttgacggtaa tcttcctggt cagctttagg cgtttcttca agttcacgca tgcttaatga 2121721 aatgcgctcc tcattttcat tcacatcaag aaccttcact tttacagtct gtccttcttc 2121781 aaggacttca tgcggcgtgc cgatgtgttt attggaaatt tgagaaatat gaacgagacc 2121841 ttcaacacct ggaaggattt caacaaaggc accgaagctt acaagacgct gtacagttcc 2121901 ttcaagcaca tcgccaggct tcactttttc gccgatttgg ttccaaggtc caggcagtgt 2121961 atctttgatc gataaagaaa tacgttcatt atcacggtca accgataaca ctttcacttt 2122021 tacttcttgt ccctcttcaa caacgtcaga cggcttctct acatgagagt gggaaagctg 2122081 tgaaatgtgt acaagtccgt cgatgccgcc aatatcaaca aacgcgccaa agtcagtcag 2122141 gcgctgtact ttgccatcaa gtacacttcc aacttcaaga gactgaagaa gttcttgttt 2122201 tttattcgct tgttcacttt caacaacagc acggtgtgaa aggatcacgc ggtttttatc 2122261 acggtcaagc tctacaacga gcagtgacag tgtttttcct ttatagtcag tgaagtcttc 2122321 aacgaaatgt gcttcaacaa gtgatgccgg aataaaaccg cgaacgccga tatcaacgac 2122381 aaggccgcct ttcacgacat ctttcacttc agcttcaaac acttcttttg tttcaaattt 2122441 tttctcaagg tcttcccaag cgcggtctgc atcaacagca cgtttagata aaatcaaagc 2122501 atcgtcttcc acttttgtta ctttcaggtc aagctcgtcg tctactttaa caacatccga 2122561 tgctttctct acatgaagac ttgataattc actgattgga ataataccgg attgtttgac 2122621 attgataatt tctacatcta catgtttgtc ttctaccttt gtcacaatcc ctttaactac 2122681 atctccaacc tctggcactt gaacatcaat ttgattcatt tcctctgtca tttgaataac 2122741 ctccttggtc caaacctaca cagcttaatt aaaacggttt gaaagctgaa catataacat 2122801 gcccgctttt agccgaatat gtattaaaga atcatccaaa aaagtttttt gaatgatcaa 2122861 taaaaagttt tattagtatt aacttctaat aaaaggacag gtttgtcaag caataacatt 2122921 ctatcttcgt tgaaaaattc aaaaaaagtg gcatttgcca tcctcagcgg gacttttgct 2122981 ccacagcctc gaggatttta tcagctacct cttgaatgga aagcgatgtc gtgtcgattt 2123041 caagagcgtc ttctgcttta cgcagcggag atacttcgcg ctctgaatca agcttgtctc 2123101 ttcttgcaat ttcctcaatt aatgtttcgt agttgacatc aaagcctttt ttcacatttt 2123161 cttcataacg gcgtttcgct ctctcttcca cagatgccaa aagaaagatt tttacttctg 2123221 catttggcag cacatgcgtc ccgatgtcac gaccatccat gacgacgccg cctttttccc 2123281 caagctgctg ctggcgtttc accatttctt ctctgacact tctgtgcttg gccgcaattg 2123341 aaacttggtt gctgatttca tctgttctga tcgcctcagt tacatcggtg ccgtttacaa 2123401 acactttttg tccatctttt gttgtaatca gctcaatgtc tgtccgcttt agcagctcag 2123461 ccagtttttc ttcatctgtc agatcaacgt tttcctgtaa agccgcgtac gtaatcgccc 2123521 gatacatcgc tcctgtatca atatatatgt acgatttttt ctcagccaca attttggcaa 2123581 cggtgctttt ccccgcagct gccgggccgt cgattgcaat cgataatttc ttttccataa 2123641 ttcctctcct tgctcttttc tcctctaagg attgtatcac gaactttatg aaaaagggtg 2123701 aaaaattgat gaataattaa tgtttgaagg tttcaatcct attgttttcc tccattttat 2123761 ccaccccttc atattgaatc acttttgata cgtatggttc aatatgctga tagtgaaaaa 2123821 gaaattggac accaagtaaa atgatggcct gaatgaacaa taatttgatc agcagccgtt 2123881 caaatgtttt cattggagca cctccattac aaatagtatg gaagtgtttg ccgatgttta 2123941 ttccattcgg gcctttcttc tcttatttaa ctggcgcctg atgcagtatt gaagcaaagc 2124001 ctgctggtca cctgctgcaa tttctgaata ctctaaagtc atttttcgtt tttctgactt 2124061 ggggtcatta aagattcgtc tgacaactgc ttctgtttct atttgacgtg tgtgctcctc 2124121 ttcaggaaga cggatgatca ggcgcaatga ttcccccgat tgaaaagaaa ggccatcagc 2124181 taaaaccacg gcgatgccgc ctgcactgat gttataggat agtgtgcgga tctcttcttc 2124241 atttcccggc tgaatttgca catctaatac cgcatcagtt cttacatatt ggcggcgctg 2124301 gattcttttc attttttcac ggggaggcat ttcaagacag atcatttgaa gtttgtcctt 2124361 cactttacct tttatacggc ttataaagcg ataaggaact tcgtcttttc ccacaaactc 2124421 taccgttact tccatatcgt tatgtaaaat cacagttcgc cctgtaacta catcaacagg 2124481 atacgcgatc aaaagttcat tgttttcgat gctgaccgcc ttgctttttg cctttttcaa 2124541 ttcattttct tctatatatt ctaaaagtac attttctcca atctctatca ttgacttcac 2124601 tctttcgcat tcaatatact cacgttttta ttaaagcacg taatgaaaaa aaggaaaaga 2124661 catttagtcc tttcctcctg tttttatagg tctttatata taggttctgc attttttagt 2124721 ttttcaacct tttcttccga tccgtctttg gcattgatat acattctgaa tgtgtcattt 2124781 tcaattgtcc caagcatttc gtagcataac acttcttgac ctagttcatt tgtaatcaaa 2124841 gcgagccttg tttctctcac ttgtacattt ttatttaatt tagactttgc ctctgcttca 2124901 gtaattgcag gcttaggtat ggttcttttt ctgtgagatg tgaggaagtc tcttgctgaa 2124961 aagccgacaa cctcaccgtc atccaaggcc actttcatac gaattgcctc ggggtacatc 2125021 cggactttat tttcaacagg aacatatgaa aatacaccga ttttatcata ttgggcactt 2125081 tcatcaattt ccaaatcatc tgtttcaaat ccgtttttct ttaaaaatgc aagcgctcgg 2125141 ttcgatccgt catttaaact gattttctga tctttcactt ctctgttttg gatcaagtat 2125201 accggatgcc cgcccttctt cgtaatatcc atataaatca ctgctttatg gtctgggtct 2125261 ttcatgctga tgctatatac atcgcgattt gttttttttc cgctctttac cactttaatt 2125321 gaataattgt catctggggc aaagcgctca gcaatttgtt ttgcttcctg ttcggaaatt 2125381 tgttttccct tcagatggct gaagcctttc tcttcttttt tcgtactggt gaaactcggg 2125441 ccaagatcag tgccagtgga gaatgcacca acattttttt cgactgtttt aaagctgttg 2125501 ataatcgtat tatcactttg tttttcgtca gaagccagag ccatttctac gtccatccag 2125561 cgaaggtttt tgctcatgac aaggtgctga acatgacgca attcattttg tatatcttcg 2125621 gactgctgat atagcttatt tagtgatgta tactcgtttt tatcaagcgg cttttggtcc 2125681 aaatctctga ctgacgtttt atagctgaaa tcgccgatct ttgataatag ctcttcagtt 2125741 ttattaaacg gcattaatgt aagcggcagc tgactgacgc tgttatgagc ttctgatgta 2125801 atcctccaca catcgatcaa tgcaggcgac agtgattttt ggctgttcat ggcaagtgtt 2125861 gttccgattt tatcatgaag ctgatccacc tgataggtaa gctcatgaaa cgcccgctga 2125921 tagttatttt cagcatgaag aagaactgcg tctttttcct ggtgttcttt gtatccccag 2125981 tagcctgtac cgactattgc aataccaagc acggcgatta aaattcctct gatcatttat 2126041 cacacctctt tttatgcttt ctcatatctg ctactcacag aaaatgtgtt taccgattct 2126101 tttaatctgc ggacgccccc aaatccacgg acttgtagcc gtatccggat taaagtagta 2126161 aagtgcttcc tctgatgggt cccagccatt gatggcatcc agcactgctt ctcgtgccgt 2126221 ttcattcggc tgcatgtaaa tttgtccgtc ggctactgct gtgaaggcaa gcggctcaaa 2126281 aataaccccc gctactgaat ttggaaataa cgggctgttc aaacggttta aaatgactgc 2126341 tgcaatagca acctgcccct cgtacggctc gccccgggct tcgccataaa ccgcttgagc 2126401 aagcagcctg atatcgttgt tggaaaatcc accaggcatg ttcgctgcta ccgcatcctg 2126461 ttttcttgct tttgctggtg tattgttttg ctgtttattc gcattcgctt taggcttctg 2126521 cgttgttttt tccgcaggct gtttctgccg tgcttctgct tgttgtcttg ccttttgtgt 2126581 tgctgctttt gatggtttcg tctgatactt tagcggaatt tttccgtaat gcgtgaatgt 2126641 attcccttta ttgagctgtt ccatgacata ttcacgatag tattttgatt tacatattaa 2126701 ggtttgcttt gttttagctc ctacaaggcc gtcaacctct tttaacccga attgatcctg 2126761 aaaatttcga actgcccagt acgtccccca tccataaacc ccgtcaattt ttccgttata 2126821 atatccgttg tattgaagac gcgcctgaag ctcgaccaca tcatcccctg ttgcccctct 2126881 ttgaatgacc tgattcgaaa aggcagagat cgtttcagta ttaataaacg tcgttattgt 2126941 aaaggaaaaa aggatgagac atgccataat cgatcctttg gacttcatct tttcaagcct 2127001 cctactgcaa atttttaagt gtaatcgtat tttctgtaac gaggttattt ttatacactc 2127061 tttccttgtt atccctcaga acataaaaac tgcacacaaa aaagccgcac ggttgctgtg 2127121 cggcttctat acttgcatca tattaacgga acgggctttt ttcgctttac gcaaaccaaa 2127181 ccaccataaa aataccataa atggaagcat ataataaatc caattgctaa gcgctgttag 2127241 gataaaatca tatgatccat gcaaaaggga tgggacaact aaagaaagag taagccactt 2127301 tacacgcgcc ttatcagcgg aaaaacgggc ttttccaagg taaaatccca ttataacgcc 2127361 aatcaaggca tggcatgaaa caggcagcag cgccctgaca aacgcatgct ccacgccgtg 2127421 gccaattaaa taaagaatat tttcgagggt tgcaaaaccg agtgatacac ttgcaccgta 2127481 cacaatcccg tcataatgct catcaaagtg ggcgtgcggg taaacactga tcatcagtat 2127541 aaaccatttt aatgattcct ccaaaaaccc cgaagataaa aaagaaacga aaaagcttcc 2127601 gcctcctaca ttctcttttt caagtacata ctggataaac atgatgggaa atacaagaac 2127661 aaccccgaga aaaaacgacc gtagcaccat atgtacaggt tcattatcat actgatcttt 2127721 taaataaaaa taacttaata acgcgatgcc gggggcaatt cctgcagaga tgattgcaaa 2127781 catcaggcaa cctctttcct ttatattcct acatctatcc taccatgttg tttaaaattt 2127841 tacatctgtc tgcacttaaa aaaacaaaaa gagcatacga atgcatcata tgctcctcat 2127901 ctttaatggt tttctctttt ggcgatttcc gctgcgatat gccccccgtg aaacctgccg 2127961 ttttcaataa atatttcatt tgcattgttt cccgcagcaa taacaccggc aataaagaca 2128021 ccttcaacgt tcgtttccat cgtttcttcg ttgaaaaatg gacgccctgt ttctttatca 2128081 atttcaacac caattttttc aagaaattga tgatcgggat gatagcctgt catggcaaat 2128141 acaaaatcat ttttaatggt aatgagttct ttctctccgg agcgaaacac aacttcattc 2128201 tcggtgattt tttcgacaca agctccaaat tccatacgga ttgtaccgtt tctgacgaga 2128261 gcttcaaatt ccggcagaat ccacggctta atgctcggag aatactcatt gcccctatat 2128321 aaaactgtga cacgcgcccc agatttcacg agttcaaggg cggcgtccac gcttgaattt 2128381 ttcccgccga tgacaacaac atctttatca aaatacgggt ggccttcttt aaaataatga 2128441 aatactttcg gcaaatcctc accgggtacg cccatatagt ttggatgatc ataatagcct 2128501 gtggcgatga tacaatatgg cgtcgtgtag gtctcttttg acgtctcaat aacgaatgtg 2128561 ttattttgcg ttttcgtcac tttacgcacc atttcaaacg cattaacacg gatgtttttc 2128621 cgtttaacga cttcccggta atacgataaa gcctgaattc tgacaggctt cctgttctct 2128681 gtaataaatg ccacatctcc gatttcgagc ttttcacttg aactgaaaaa ggtttgatgc 2128741 gtcgggtaat tgtaaatact gttaacgaca ttgccttttt cgatgacgag ggcatcaatg 2128801 ccaatttgtt ttaggtgaat ggcagcagat agtccacaag gtcctccgcc tataataatt 2128861 gctttttctt gaatcatttc tgtcaactcc tgcgattggc atttcacttc atattttcta 2128921 tttccgaata aaaaaatctc ctattttatc ataggagatt ttttattttt atgcaaatca 2128981 tcaacttata tccagcctct aaaacgcgaa gcttcagcca ttttgcgaac gccgaccata 2129041 tatgcagcga gcctcatgtc aattcttcgg ttgttagcca tttcgtaaat attgttaaat 2129101 gatttgacca tcattttttc taatttttct tctacctctt cttcactcca gtagaagcct 2129161 tggttattct gaacccattc aaaataagaa actgttacgc caccggcact tgccagcacg 2129221 tctggtacaa gcagaatgtc ccggtctgaa agaatttttg ttccttcaag cgttgttggt 2129281 ccgttcgctg cttcaacgac aattttagcc cggatattat gggcattttc ttctgtaatt 2129341 tgattttcaa tcgcagcagg aacgagaata tcacaatcca gctccagcag ctcttggttg 2129401 gtaatggtat cgttgaaaag ctttgttacg gtaccgaagc tgtcgcgtcg gtcgagtaaa 2129461 taatcgatat caaggccttc cggatcataa agtccgccat acgcatctga gatgccgaca 2129521 acttttgccc ccgcatcatg cataaatttt gccaaatagc ttcccgcgtt tccgaagcct 2129581 tggacaacga cacgcgcacc tttaatatcg atgcctctct tcttagccgc ttctttaata 2129641 cagatggtaa caccttttgc tgtcgcagat tctctcccgt gagatccgcc aagcacaagc 2129701 ggtttgcctg taataaatcc aggcgaatta aattcatcaa ttcttgaata ctcatccatc 2129761 atccaagcca tgatttgtga gtttgtaaat acatccggtg ccggcacgtc ttttgtcggg 2129821 ccgacaattt ggctgatcgc tctgacatac cctctgctca gacgctccag ctctctaaac 2129881 gacatatccc ttggatcaca aacaattccg cctttaccac cgccatatgg aagatcaatt 2129941 atgccgcatt ttaaactcat ccaaattgaa agcgccttca ccgccttcac ctctttttct 2130001 gttacgttcg ggtgaaaacg tatcccgcct ttcgttggac cgacagagtc attgtgctgc 2130061 gcacgatatc ctgtgaaaat ctttactgaa ccgtcgtcca tacgaacagg tatttttacc 2130121 gttaataatc tcatcggctc ttttaacaat tcgtatacct cttcgggata tcccaatttt 2130181 tccagagcct tatgtattac ggtttgggtt gattttaata catcaagttt gtcctcttct 2130241 gtatgaccgg tgtttcgatc ggctgccatt tgagttaacc tcctagaatc ttctgtttct 2130301 cacatgctcc ctttcagaga atagtataca ccttcatatg atctgtgcat agaataaacg 2130361 ttatgttttt ccatgttttt taacgaaaaa aaactgctga aatcagcagt tttccgttgc 2130421 attcttatga aaaatgagtt tgtatcgttt ctacggcatt accgtccata atgagcttac 2130481 catactcttg caggcgataa atcgttaaag ttgtcggatt gccgtattca gccagaaccg 2130541 ccacaacccc ttcagccgta tgtgacccta gatcttcaag gcttaaaaag tactgcccgt 2130601 catagtggta gacagttccc cctgtgatac cgattcgctg taagctttct gaaagctgaa 2130661 tgatatcttc aaaggaatgg aattgatata tgatgtccgc gctttcatca agcttgactt 2130721 gcatttcgat gtaatcatca tcatactcat cgtcttctga atcggcgtct tggttctttg 2130781 ttacaatcac gaccatccct tgtgcttgga gagaatacac ttccactgca atcggtccat 2130841 tcgcttcaaa gccgagctct gtatttgctt cattcatcat atctttaaat aactggtgga 2130901 ctttaaatga gtccttccag aggtcttctt ttgtcaatcc ccggtctgtc aaatcatcga 2130961 gggttaaaaa gattttgatc ttattataat tcagacgctc aagccgcata acgttccctc 2131021 ctgcctctac ttgcacacaa atcatataac acattatatg agatgatgag tcataggttc 2131081 ttaattgtta tcagtttaca ctgagttcac tagtaagaca agcacaatgc agtttttatt 2131141 gccatacgga tttttgcttt ttagaagtta ttctggcccg caaagagtca caatgtgagt 2131201 ttcaggctca gcacctaaac gaagaggcac ttttgtcgtg ccgtagccgt tgctgatcag 2131261 atatgccgcg tttttaacaa tacctgtttt ccccagttca taaggaccga attttccaaa 2131321 cctgatctgg cctccatggg tatgtccgct gagtatcaca tcaataccgt catcttcatt 2131381 gatttgttca tgaatctccg gattatggca aaccagaata ttcagctggc tttcatcaag 2131441 ttctttgatg gcttcctcat aatgatccat ctccatcctg atatcatcaa cccccgcaat 2131501 cgcaatcgta tgcccattgt atgaaaacgg gactgactca tttctcagag tgatgacgcc 2131561 gtgcgcttta aatatggaat acagcttatg ctgcctgact tcataatcat tattccccca 2131621 cacaaacacg atagggaccc cgaaatgtac gagccttttg atgttttcct cgattctcgc 2131681 actgggcacc ccgccctcag ctaaatcacc gccgattata accaagtggg gggcatggct 2131741 tcgcgctttt tctaaaaggt cttgatcgat gagacgtttg tgaatgtctg aaataaaaaa 2131801 gattgtcaga ggcggcttgc ccttcatctt tgataaagga aacgtatgtg tcttcaaatg 2131861 attgcctttt gctgttgcat acatttttgc cgtcattgcc gctgccgcaa cagttagtac 2131921 accggcaatt ttcactgata gcttcataaa aaactctcca ttctttttag aacttatcaa 2131981 taagacggac aataaaaaaa gacgtttcta tcgtttgaga aaacgcccca ttttatttac 2132041 tttcaaaata tagattaatg tcatatttgt gcttcatcat atgaaaaaca gactctctcg 2132101 ccttccattt atcgggctgc ggccagagat cagtgctttt ctgaataatt tcacatctca 2132161 gtttatggaa atcagtctcg gatttttctt cctttttctt gaaataatat gaagtgcagt 2132221 aggcaaaagc ggttgccagc atccaaaata aataaaaggt atggctaagt atttcttgaa 2132281 gtataagctg aggctccggg cttttgatca tgatcataac acataataag cctaggcaga 2132341 taagtgaagc ccatcgccat ctgcggcatt gtgctgcata attttcgaat ttttgttttc 2132401 gttttaccag cgcttggagc atctgtttgg tcggcgcgtc tgtaaactga tccagctgat 2132461 tccataagga ttccatacgc ttcacacctt gtccattttc attgctacaa tatatgaacg 2132521 taaaataaaa ataataccct attcatccat taaagggatg tccaaaactt gtccggtgta 2132581 aacatcattt ccattcagat gattatatgc tcgaattttt tcttctcctg tccggctttt 2132641 ataatacttc atggaaatgc ggtatagcgt ttctttcttt tggacggtgt gcttgacaac 2132701 gcgattcggc acattttgaa ctggctcagc tggctgttct tgctgttgta ctgttgattg 2132761 ggaagaggaa gcagccgcgg cggttgcttc ctccttattt ggcgagtctt ctttttccgc 2132821 tacagcagtc tgtttcttat cagcagctgt ttgctctttt ggcttggaat cttctggctc 2132881 tttttttgac tccttctgca gtgcggtttc tttagtgtct gcggtatcgt ttttatcctc 2132941 tgatttcggg acaacctcat atttgctttg gctgctgtca ataaaaacat cttcataatc 2133001 gtcatgatta tccgggtggc tctttagata aaataaggtg actaaaacga taaccggcac 2133061 aaatacaaat attactgcga gtactgtgaa taatggcgtt tttgttttgc cttgcttttt 2133121 tttctgttct ctttgatttt ttacagattg tcttgtcgga aggctttctc catcatcgac 2133181 ataatcgtcc gccaatgcgg cgttttgatc ttcataaaga ttctgggctt ttcttctctc 2133241 tactctcgac atgttcgtca tgtttatccc tcctcacatg ttcaaaacga atctgacagg 2133301 caaacacggc atcaatgata aaatgcgccg tcatcggaac aaataagttg ccggtccatt 2133361 catacatcag accgagcaaa aagctgattg ctgtcaccat aataaataac agccattttg 2133421 acaaataccg aaagtgcaga gcggcaaata taaggctggc cgtccataaa ccgatatgag 2133481 tctgcagcac tcctctgaat aacatttctt ccgcgaaagc aatcagaagc gttaaaaata 2133541 taatatgagg gattgacctc ttactgaata tttttttatt gattccgccg tcatcatata 2133601 aatgagacgg aaaccatttc attactgcca tatcggctaa aataacaata acagctatag 2133661 aaacaccata ccagatgatt cgcatatcgc gaatgtccca gagctttaat acgtcccgta 2133721 catcctcaaa aaagaacagt cctgctgcag cagcggcaaa gatgatgagt agctgcgtca 2133781 aatataactg cttcagcata tcatggtcag tcatatgctg aatataatct ttttgctgtt 2133841 tcagttcagc tcacctacag tctgcaagct gaatatccgg tgcaattccg aactccagct 2133901 gtctaatggc gccattttac tccgttcccc tttttgttca tacaaggata aatcaaaacc 2133961 gcaatgtgaa cagcacggga ggtttccgtc atcaggctcg tatgattcat caaagtaggt 2134021 taacagtgcc tgccttaaac agccgtcacg ctgaagcaaa aatgatacac ggtgcatttt 2134081 ttccagcttc agctccatgc gatatgaaat ttctttcttc atcagttcaa ctgatgtttt 2134141 tccctgcata aagagatgaa tcatcatacg ggcctgtgtc tctccgacgc catactgaag 2134201 taatacgtca cgcagccttc tctcatcccg ctcctccgtc ttctctagca cacggattac 2134261 gtcggcgatt tcttcagctg tgacactctc catctggata atttgttcct gcaattcaaa 2134321 atcccctggc gcccgcagca aaatgctgac actcggcttt ccgtcgcgtc ccgctctgcc 2134381 gatttcctgc ataaaagctt ctgccgtctg cgggagatga aaatgaatca catatctgat 2134441 atcaggttta tcgacaccca ttccaaacgc attcgtacaa catatcacat caagctggtt 2134501 atgaataaac tgctgctgaa ttaaaatcct gtcccctgac tccaaaccgc catggtaaaa 2134561 gtcggctctg ctgctcgttt tgcttttaat ttcacccgct aattccttag cccatttccg 2134621 tgttggacaa taaacaattc ccggaccttg caggttttca accagctgaa tgaccctatc 2134681 tattttttcg gcagtatccg ccgcattttc aaccctcagt gcgatgtttg ggcggttgac 2134741 tgagttgaga tggcgtacag catgctgcag ctccagcagg ttcatgacat cttgcagcgt 2134801 ttcctttgta gccgtggcgg tcaatgccag aacgggtggg tgtccaagtt tttttctcag 2134861 ctgtccgagc tttgaataat caggcctgaa gtcgtgtccc cattcagaaa tacaatgcgc 2134921 ttcgtcaata acaaataggc taatcggaac gcttttcaat ttttccaata catatggaga 2134981 ctgtaaagct tcaggagaca agtacaaaaa tttatatcga tgaatatgtt ctaaaacaaa 2135041 ttgtctttcc tgcctgttaa gcatgctgtt caaagctgca gcacgctttt ccccccgggc 2135101 tttgagctgc tgcacctgat cctccattaa agaaagcagt ggagaaacga ttaataccat 2135161 gccatcaagc atataaccag gcagctggta gcaaagcgat ttccctcccc cagtcgggag 2135221 cattgcaatg gtatccttcc cgctgagtat gctttcaata atgtcctgct gccctttttt 2135281 aaaggaagta aaaccaaaaa actgatataa cgtttgctgt aatttagtca tattgctgca 2135341 cctgctttgt caatgccagt ctgatttgaa agtagctgaa ccgctgttcc agcccgtcgc 2135401 gaatttgttt gattttattc gtccgcatcc gtttggcaaa ctctgcgatt tgaagctggt 2135461 cttctgctga tacatagtca ttaatcataa acgcaggctc atggagagaa atctcgacaa 2135521 tgtggtcttc aatcgtcgct gttttcagct ttctgatttc agcaattcgc tgtatcggaa 2135581 acccttgttt gaccatctgc catgttttcc tcgtcgactc tgtcagggca ttatctaagt 2135641 gcacatcaga aaggagatcc tttaacaaag catcttcaca ctccggaaga gaatgaataa 2135701 aataatgtac cgaagcccaa aacatgatat agacatacca ttcgtcttct ttcagcgtat 2135761 cagcaagctg cctgctcgta taaccgatcc gatggtgcga ggttaaggag tagacaaaaa 2135821 tttgcgctgc tttgttttca atctttttca aatgcgcctc aagcatggca aaaaggcttt 2135881 ttgccatctc tatatgatcc gtatgccggg acaggtattt ctttacccag tgaagtgtct 2135941 tatgatcctt tgtgacaggg atatactgcc tgctcccttg ctgtttatgg gataggacct 2136001 gcacaagcag cgaaagcctt ttccaaagca cgccggcagc ctgctgataa tgagcgccgt 2136061 gacaatgaac gggccaaggc cgctcgctaa gggcatgtct caaaactgct gcgccgctgg 2136121 ctgtcacttt gtatgtatct gattcagaca ttggcgcgag atatgaatgc ttttcaagct 2136181 tgtcaagcga cgcagaaata tcgcttctcg aacattttgc cgccattcca aagtattttg 2136241 cagtctgaaa taagccggca tcttgaatgg tctgtgacga tctcttgcct ttgaataggt 2136301 gaaaaacagc gcttcccgac cgttccccgt ttattttgca aagacaatcg agaaccataa 2136361 tatcgaagta atttaatgac aacctatcca cctacattct tcctgacaaa aatcgttgat 2136421 ttgctctttt tattttaaca gatttcaaac agaaatcgac gtttaaagtc atcattaagg 2136481 gggatgttat gtagataacc ccttatgtga taagcattct caatcatttt tctgttgaaa 2136541 tgtggcagca acatcattac aataagtaag aggaataggt gttaaattga ttaaatataa 2136601 agattgatcc atttgttcca ccaagaacaa tctgggaggt tttattcatg gcaaagtaca 2136661 caatcgtaga caaagataca tgtattgcat gcggcgcttg cggagctgct gcaccagaca 2136721 tttacgatta cgatgatgaa ggcatcgcgt tcgtaacgct tgatgaaaac aaaggtgttg 2136781 tcgaagttcc tgaggtactg gaagaagata tgattgacgc atttgaagga tgccctactg 2136841 attccatcaa agtggcggat gagccatttg aaggcgaccc gcttaaattt gaatagaagt 2136901 aactaaaaaa agctcccgaa cgggagcttt tttatttaat ggatatgtgc acttcgctgc 2136961 tgctcaatcc atggcttaag cttgataaaa attagtgaga atacaaccgt aattacaata 2137021 ccttttatca tgttaaacgg caggatacct gcgacgactg ctgtttttag cgcgctgtcg 2137081 gataatgccg gtgaatgtaa aaaccacgtg tatgccggaa gaatcagaac ataatttaaa 2137141 atactcatta aaatggtcat cgctgcagtt cccaaaagca ggctgacagc caagcccttt 2137201 gctgagttga gttttttaaa taagaaagca gtcggtaata taaagagtgt tcctgcaata 2137261 aaattcgcaa cttgccctac aggaactccg gccatgcttc cctgaatgat atactgaaga 2137321 acatttttta tcgcttctac ggcaataccc gccaaaggtc cgtaaatcag aatggcaata 2137381 attgcgggaa cgtcgctaaa atcgattttt aaataatccg gaagacccgg aaacgggaaa 2137441 tttaacagca tcaaaacaaa tgcaatgctg ctcagcatgc tgaccacaac taattttttt 2137501 actttcactt cattctctcc ttttcgatca catcttactc gaaaacggaa aggttctttt 2137561 ccagccaata aaaaaaccgc ttcatatata aaagcggggt ttcgaaaatt aggctaggca 2137621 aagaaacgtt tgaaaaattc aatttcaaaa cgcttatgaa cctccatctt ctcccatcca 2137681 gactgtactg tcggctccgg aatctcaccg aatcctgctg taaagacagc tcgcgggctt 2137741 agagccattg gctcatcacc gccggtaggg aatttcaccc tgccccgaag attgatcata 2137801 tgaaatttaa ttacattata aacgataact ggttggctgt atagagaatt gcttcaaatt 2137861 aaatatatta cctgcaagct gtcagatcat tgatttatta ggctttactt ttatccttta 2137921 ctgcgtcaat acacgttgac actcttttga gaatatgtta aattatcaga tatttagttt 2137981 gtcaatttag gaggaaatct aacgatgttt cgagtattgg tctcagacaa aatgagcaac 2138041 gacggtttac agccacttat tgaatcagac tttattgaaa tcgttcaaaa aaacgtagca 2138101 gatgcagaag atgaattaca tacttttgat gctcttttgg tgcgaagcgc gacaaaagta 2138161 acagaagacc ttttcaacaa aatgacttct ttaaaaattg tcggaagagc cggtgtcggt 2138221 gtcgataata tcgatattga tgaggctacg aaacacgggg taatcgtgat caatgctccg 2138281 aacggcaaca ccatttcgac agctgagcat acatttgcaa tgatctcttc tttaatgaga 2138341 cacattccgc aggctaatat ctcagtgaaa tccagagagt ggaaccgcac agcttatgtc 2138401 ggttcagagc tttatggaaa aacgcttggt attgtaggat taggccgaat cggaagtgaa 2138461 attgcacagc gtgcgagagc gttcggtatg actgtgcacg tttttgatcc tttcttaacg 2138521 gaagaaagag cgaaaaaaat cggcgtaaac agccgtacat ttgaagaagt gcttgaaagt 2138581 gcggatatca ttaccgttca cacgccttta acaaaagaaa caaaaggctt attgaataaa 2138641 gaaacgattg caaaaacgaa aaaaggcgtt cgcttaatta actgtgcgcg aggcggaatt 2138701 atcgatgaag cagcacttct cgaagctttg gaaaacgggc atgttgcggg agcagcgctt 2138761 gacgttttcg aagtcgaacc gccagttgac aacaaacttg ttgatcatcc attagtcatt 2138821 gccactcctc acttgggagc atcaacgaaa gaagcacagc tcaatgtcgc cgcccaagtg 2138881 tcagaagaag ttctgcagtt cgcaaaaggc ctgcctgtca tgtcagctat caacctgcct 2138941 gccatgacaa aagatgaatt tgctaaaatt aagccttacc atcaaattgc aggaaaaatt 2139001 ggcagccttg tatcacagtg catgaaagaa ccagtacagg atgttgccat tcaatatgaa 2139061 ggcacaattg ctaaacttga aacatcgttc attacaaaag cccttctgtc aggcttttta 2139121 aaaccgcgcg tagactctac tgttaatgag gtcaatgccg ggggtgtcgc aaaagaacgc 2139181 ggcattagct tcagtgaaaa aatttcctct tctgaatctg gatacgataa ctgcatcagc 2139241 gtaaaagtga caggagaccg cagcaccttt actgtaacgg ctacgtatat tcctcatttc 2139301 ggagaacgaa ttgtcgagat caatggattt aatattgatt tttatccgac tggtcacttg 2139361 gtgtatatcc agcatcaaga tacaacaggt gtcatcggcc gagtaggacg tattctcgga 2139421 gataatgata ttaacattgc aactatgcag gttggccgta aggaaaaagg cggagaagcc 2139481 atcatgatgc tttcctttga cagacatctg gaagataaaa ttgtgaaaga actaacaaat 2139541 gtccctgata ttgtgtctgt gaagctcatt gatctgccat aattaaaaaa actcaagcta 2139601 tatagcttga gtttttttat tgttctatcc ccgtgtgttt ttatgcaaaa tatctaagac 2139661 actccttagc tcagaaacag gaatttggcc tggtgcggac gcctcttctc cagctccaaa 2139721 agtacaagcc gatccaaaaa cctcaccgct cagcctgctg atgagccctg ttgcagccat 2139781 tgacattgta ataatggggc ggtctgcata tattgttttc attgtatacg tcgcatcaag 2139841 cagtgttagg agatctccag tatcattcgg catgacagcc atttttggaa tatgcgcgcc 2139901 taagtcctgc atttttcgaa gtctggaaat aatttcatct tttacaggtg ttttttcaaa 2139961 gtcgtgattt gacatcacca catagacgtt gttttcttcc gccagcgata ctaacgcttt 2140021 tacatttgca tctcctgaaa ataattcgat gtctatcaga tcgatgtctt ttgtttggat 2140081 tgccgattcc agcaaagcaa gataggagct ttcgtccatc tccatgctcc cgccctcttt 2140141 gtgggttctg aatgtaaata gaaatagctt gtcttctaaa gatttacgaa gcttagaaat 2140201 gagctttgtg accgcttctc tgtcattcgc tttttcaaat acgtcgactc tccattcaac 2140261 aatgtccgga ttcagtaatt ttactgcctc tgcttcattc agaatttgtt tttccgtctt 2140321 tcccatcagc ggaatgatga ttttcggcat cccttccccg atggaaactc ctttaatcgt 2140381 taacacgttc actcgtctca aatcctttca atctttacct tgttttatta tacacgtaca 2140441 actttttttt gaaaatttct attatatgaa tagcaactaa aaaagagcct taaagggctc 2140501 tttttagttt aaggaaatcg gatttggagc agctggcacc ggaattgcat ctgatatgtc 2140561 atatttgccg atttttttcg ttctggtttc cgtaaaggtc acttctgtga agccaaactc 2140621 ttttgcagtc aaaagtagtc cctcaatcat taaaataccg gcaatagaat catcaacttc 2140681 tgactccttt gaaaagcgga tatataagtg tttctgtttc ttcgttacag attggacagc 2140741 acccgcttga ataagaggtg tcgtatcttc ttggctgctc gattccattt ccttaatcgc 2140801 ttcttttact gtatcaaaag aatgatttga cggaacgaga aagtcttgtc cttgtttatt 2140861 ttggtacaag tagtaggatc gttttgactg tttgggaatc gaaatttccg taaaagtgcc 2140921 atatgagcca atccgaaccc cagtctcatt ttgatccgat aaaaatttga ctttttcata 2140981 aggactccat tttaaggatt ctttaagcaa tttttttaac agtgtatcat cttttataga 2141041 aaatgccgta gctggctgat ggactcgtat acttaattcc ttctgctttg gtttttcctt 2141101 tatttctact tcatctatga aggttggaat tgtaatggca tgatcaagga tgcccaattc 2141161 actactttca aacagcatat cctggatcgt ttggtctgca tttgtttttt gaatgctgac 2141221 gggtatgatt gcagatgtat cggcatcagc aaccgctaca gtgatgtaat tgtcttgttc 2141281 cttttcagga acgacaaacg atgtctgatc caaggacgat gcagcttttg ggctgtcttc 2141341 tgtctcagtt ttcgttactg cgttctcttg ggacgcttct ttttgttgag gctgtgcctg 2141401 atcaaagaaa tgaggagaaa taatgaaggc gatataaacc gcaattgcag cggcacacgc 2141461 ggggccaatc cacctgacag cgggcttatt tttacgcttt gccatcgtca gccgcttgta 2141521 aatatcctga ggcgaacgat ggtctttaac tgccggaagt tgacttaaca actcctttat 2141581 ctgttcttcg ttccattctg acttcatcat ccattagctc ctccctcaaa agctccatat 2141641 gtttccgaag tactttgagc cctctgtgtt gggtcgtttt tactttgctt tccgagaagc 2141701 gcagagcctt ggctgtttcc tgtattgaat atccctgaat aaaccgcaag ataatcacag 2141761 ctctttgatc gattgtacat tgatcaagcg cagcataaat ttcccggaca ttttcatgtt 2141821 gaaccgcaag ttcgtccggc agcaattgct gatccctgac atcctgtgta tcccagtcaa 2141881 atgtaccgag tatacgctgt ctgattgttt gctgtttacg gaaccagtct atcgcaacat 2141941 ggcgtgcgat agacaaaagc catgtttttt cactgcttct tccttcaaac gtatgataag 2142001 aatttaatac ccggatataa acctcttgaa gaaggtcttc tgtctggttt ttatccttta 2142061 ccatataaaa taaaaattgg tacaaatctt gatgatatgt atcatataat aattgaaagg 2142121 tttcttccat ttgaaacccc tccgttcact tttttgtcgt atgaatagct tgaaaagtta 2142181 cattacaact atattacgag taactggaat ttggaaggga atttatatta acatatcctt 2142241 aaattttatt aatgttggct attaaaaaaa cacccgctca gtcagcgggt gtttcttatg 2142301 gaacaagatt cttcggcaaa ttcagactcg attttaccgt tttgtcggaa tataaaaaga 2142361 aaatgttgtt cctttatcta ttcggctgtg cacagtaatt gatccgttgt gggcttccac 2142421 gatattttta acgatagcca gccctaaccc ggttcctgct ctgccccttg tccgcgcttt 2142481 atctgcctta taaaaccgct caaagataaa tggcagatct tcttccggta tgccagaccc 2142541 ggagtctttg atatcaattt tcaatccatc cttcacagaa tggactgaaa tggagacact 2142601 gccgccggct gaagtatgcc gcagcgcgtt atcaatcaaa ttggtaaata cctgctccat 2142661 cttgtcttca tcaaacataa attcctcttc tgtgagagaa atgtcatgat ctaaagcaat 2142721 atttttttct ttcgcaacac cggaaaactt ccgaatgatc ttttctaaaa actcattcac 2142781 attgattttt tcataatgta agcctgtatg gcctgattcc attcgggcta aatcaagcaa 2142841 atcattaact aaacggccca ttcggagcga ttcgtcataa atgatttggg caatttcttt 2142901 ccggtcttct tcagagcttg caatgtcatc gacaattgct tcactgtatc cctgaagcat 2142961 ggagatcggt gttctcagct catgactgac atttgcgata aagtcctccc gcagcttatc 2143021 aaggcggcgt tcttctgtca tgtcacgcag tacggcaacc gctcctctga cgtgcgattc 2143081 cgcataaagc ggcgacatca aaagcaccca tgatctgcct tgaagcgtca tctcaatcat 2143141 ttgttctttt tcagtgctga cagcgttttg aaacagctct tttgcttcag gcggaagatt 2143201 gtcgccttct ttgatattca tgttctgttc ataataccaa gcctgaagaa aacgttcagc 2143261 cggcgggttg gtcacaagaa tcgtaccgtc aatattaatg gtaataaccc cgtcagccat 2143321 actgctcaaa atgttagaaa gctgctcttt ttcttgattg agcgcattga tatgaaagtt 2143381 aagctgccgg cccatttgat taaaagcggt cgccagttca ccgatttcat cctgagttaa 2143441 aatcgggatt tttgtatcga acttgccctt cgccaaatcc tgcgcgcctt ctctcatttt 2143501 tcggagaggg tacgtgaccc tgcttgataa aaagaatgcg aaaaatgtgg tcagcacaat 2143561 cgcaattcca gcggcaagaa aaatatagcg ggtcgtatgt tttgttgtat ctttaacggc 2143621 aagcaaagac tgggataaaa agaccatgcc tttctttccg tctttttcat acgggacacc 2143681 tacaatcagg cgttcattat ccgtgtctgt atcgctcagt cccgtccgtt tgcttacttt 2143741 tttatggtct ttgagagctt tatttaagtc tttgtcatgc tgtatttgct caaccgtaat 2143801 agacgacagg cgatttttat cattcggaga ataccagtgg ttcttctcat cctggatgat 2143861 ggcaatgctt gttaagttat cagcgagttc ccaagtgatt gaccttgcca gtgcctggtc 2143921 ctcgtgattt tctaggatga cagcaacttt attcgcaagc tgtgttaaat cattctcagc 2143981 ttcttccaca tggtagtttt caataaactc cagcaaaaga accgttaaaa tgaacaatac 2144041 gatcaagacg agtgaaagga tcgtaaacca cagcttgcct actacgcttt tccaaaattt 2144101 cattcagcgc cgacctcaaa tttataacct acaccccata cggtgacaat ttttttcgca 2144161 gcttccggag ataccttgtt cagcttctct ctcaagcgtt tgacgtgagt gtccactgtc 2144221 cgtaaatcac caaaaaactc atattgccac acttctttca gaagcttttc ccgatcatac 2144281 accttgtcag gcgttttcgc taagaaatat agaagctcat actcttttgg cgtcaggctc 2144341 acttctgttc catcagctgt tacgcggtga gcatcatggt ctattgacag atgtgaaaac 2144401 acgagcacat ttttcgtcgg tgtattggca ttgaaataag aggtttggga tgctcttctc 2144461 aaaagggcct ttacacgcag cacgacttct ctcgggctga acggcttaac aatataatca 2144521 tctgttcccg cttcaaaccc ctgcacccgg tttgcttctt ctccttttgc ggtcagcata 2144581 ataatgggtg tcgctttttt ttcacgaatt tgccggcaca cttcaattcc atcagtcccc 2144641 ggcatcatca gatcaagcaa aattaagtca taattggctt caagcccttt ggcaatggct 2144701 tcatcaccat tttcagcttc atctatagca taattttcac gttcaagata cattcttaaa 2144761 aggcggcgaa ttctggcttc gtcatcaact actaatattt ttgtttcgtt cgtttggtcc 2144821 atgttttccc cctgctttcc ttctgttact ttcattttat caaatcgtga gaaagtttga 2144881 gaactgtgtc gctttcaaag gactatgcat aagaatgaag tccggcaagc acaagattta 2144941 cgaatattaa attaaacata ataatagcaa aaccgattac ggccagccat gctgacttct 2145001 caccgtgcca gcctcttgac agtcttaaat gcaagtaagc ggcatagaac aaaaatgtga 2145061 tcagcgccca tacttcctta gggtcccagc cccaaaatct ggtccacgcg agctgagccc 2145121 aaatcattgc aaagatcagc gcgccgagtg taaagatcgg aaatccgatt gatacggccc 2145181 tgtacccaac ctcatccacc agatcaagat tgacgttttt caccagcgga tgtaatagag 2145241 cgctgattct ttttctgatg atcagacgga gagccccata caacacaaga cctgctccaa 2145301 atgaccaaat gacagtgttc acttttctgc ctgagaaaag cgcgggaaga tcaacaagcg 2145361 gttccattct tccttcggtc aaaagctctc cctgatgcgg accgacaagc gcgggcattt 2145421 cgtacaccat cacgcttttt tctttacttt tgtccaccca gttaaactcc gcttcatagc 2145481 ctgcaagacg aaatgccgat gtgattgcaa taaaggcgac ggttgtgacc aggataaaca 2145541 taatcgcttc aagccagaag gtctttttgc ttggctttgt ctggtctaca tgcttcaaaa 2145601 gaaagatgac accagcgaca aagctgatgg caagtatagc ttgcccaagc gcggccgttg 2145661 ttacgtgaat atacagccag ttactttgga gcgaaggaat taaaggcgag atatctgtcg 2145721 gaaacatgct ggcgtaggca atcagcaata aagcaattga cagcgtaaac aggcctaatg 2145781 aaggcaatct atagagaaaa taaagaatga taaacgccaa aacaagcatc atgccaaaag 2145841 cggtggtgaa ttcaaacata ttgctgacag gcgcatggcc gcttgcagcc caccttgtga 2145901 tgaaatatcc taggtggcag aaaaaaccga caatagaaag ggtgattcca atgttggccc 2145961 atcggtttgg cctgcccttt ttatctttat tcccgcgtat ggccccgccg aagattggga 2146021 cagcgattaa atacacaaga aaggccgcat aaagaaaatt tccgctcagc tctgccatga 2146081 catcactccc ttttcgccta tttctgtgtt ttgattaatt ctttttggtc caccggttca 2146141 gtcagtccgg aatcagccaa tataaatgct aaatccttct tcaggccaaa ccagttttta 2146201 ttggtatgcc ctgctaccat aactgcaccg tcctgtgagt gcagccaaat tcttcgatgc 2146261 tgccagtaca taccttgaat gacaccgatc ataaaaatgg ctccgccgac agcaagcacc 2146321 cagagtgtca gatcctttct gactgtaagt ccagtaatgt ttttcgtttc gacatggtca 2146381 aatttcagct tgtatttatt attgcctgat ccttcgatgg tttcttggat ggcgacaaag 2146441 ctcttttcgc ctttcggttt gtccggcgtt atgatattaa agacaaaagc cggattgtta 2146501 gggatctttg tttttgtgct cggctctccg tcctgattaa aatagaagtc aggcaggtag 2146561 ctggcgattt ccaccttgta accgttacca agatcataga ctgaatctgg atccagaagg 2146621 ttgatcttca ggctcccaaa ggattttttt gtttttttat caatcagctg gaacaccatt 2146681 tggtcaagct gattctcttt gtaatccacc tggtaaacgg aaaaagaatc aaaacgcagc 2146741 ggctgattga cacggatgtc ttcttctgtt actttttcca gcttcggctt ctcgccataa 2146801 acaatttttc cttctctctt gtagagtacg gcatcagttt gaaagttctt tgccactcta 2146861 ccgtccccga ctctgtcaat ggcatctgca aatacctttt tttccgtttt gctgttatag 2146921 gtctctacgc tgaattgatt gtttttcaaa taatattttc cgtctgtacc cggaattgct 2146981 gcggtttcgc cttctctgac ccaaagcgtc tcatcgacgt acatgccagg cacaaatctc 2147041 agcatcgcac caatcagaaa gatgatcaat ccaatgtggt tgacatacgg gccccagcgg 2147101 gaaaagcgtc ctttttcagc aagaatgctg ccctcttttt ctctgattct ataatgtttt 2147161 ttctttaata gagtaactat cttttctttc gattccccgt tcagtacagt aactgtttca 2147221 ctgaacaagc gctgccttct taaaaaggcc gggctccttc tgacaccttg gttttttaac 2147281 gctctataca acggaatgac ccgatcaagg ctgcaaatca cgagtgaaat gccgatcgag 2147341 gcaatgagca gcaaatacca ccaagaacca tataaatgat gaaacccgag caaataataa 2147401 agctggccaa acgtgccgta ctgctccttg taataagtat cagcctgtgc gcccggaggc 2147461 agataggctt cctggggaaa aatggtgccg aacgctgatg cggcaagggt tatgacgata 2147521 agccatattc ccaccttaac cgaggaaaag aaattccaaa ttttgtcgat gatcgttttg 2147581 ttataggttt gcgaacgtct tgcgcttccg tcatatctca tatcagcgag cggaggttga 2147641 gtttcctgaa gagctcttcc gcacgattcg cataaaacgg ttccgaccgg gtttatatgt 2147701 ccgcattcac atttgacttg cttcatcccg aagtctctcc gggttttatg agattcatat 2147761 aatcgtgtat catgctttct gtcatagtgc cggtcaccac cttgacaact tttccttccg 2147821 gattgatcaa aaaggttgtc ggaagcggag atacgtcata ggcatcaagc acttggcgat 2147881 ctgtatccag aacaaccggg aaattgactc cgtaggattt cataaaatta tgtactgcta 2147941 tctttgactc cccaacattt acagcgacaa tttcaacacc ttggctttta aaatgcttat 2148001 attggtttgc catataagga aactcttttt tgcacggttc acaccatgta ccccagaaat 2148061 tcaaaaaaac acctttccct tttaagtcac tgagctcgat acgtttccca ttcgtatcct 2148121 ctaggacaaa attcggtgcg tcggaccctt cggatatact ctctttgccg gcaaatacag 2148181 cgttgtaaat ggtatagccg agtgcgcaga ttaaaacgag aaggatgccg gtccgaatga 2148241 ataaacgcct ttttttcttc attgtccact gcccccttcc ccctattgca gatccattca 2148301 attatatcat tgcacgttca tttcacattt cttacttttt gaaggttatg tgaaatttag 2148361 aaagcgtttt taccgtgatc cgccagtgct ctgagccttt ttacttcgtg aggcgtaagc 2148421 tctctggcat cgcccgtgtg caggcctcgc aggtttaaaa acgcgtattc ctcacgcttc 2148481 agcttgatta cctcatgtcc gatcgcttca aacatgcggc gcacttgtct gttgcgtccc 2148541 tcatggatcg tcagctgaat aatgcttgtc tgctttttct tatccaaaga cagcagcttc 2148601 gctttagcag gcgctgtttt gccttcctcc agcctaattc cgcgctccag ctttctgagc 2148661 agctctttag gcgggattcc tttcaccttc gccacgtatg ttttgtctat ttcatactta 2148721 ggatgcatta gcttattggc gaattcgccg tcattggtta aaagcaaaag accgctcgta 2148781 tcatagtcca gacgcccaat cggataaatg cgctgcggaa tatttttaaa aaagtccgtc 2148841 accactttgc gtcctttatc atcttgcgct gcggaaataa cgcctcttgg tttatataag 2148901 agaaagtaaa ccggctcttc gcgttcaacc tttaacccgt ttacctcaat ctgatcagaa 2148961 ccggtgacct taacacctag ctctgttact actttgccat tcacctttac ttttccttct 2149021 ttaatcagct cttctgcctt tctgcgcgac gcaactccgg catgagcaat cactttttgc 2149081 agtctttcca tgtctttcac ctcaagtatt atcttacttt tttcaacctt aacaaacaag 2149141 ctttttcaaa ttcctatgcc aaatctaaaa aaaacgccgt tttcaggcgc tcccaaataa 2149201 taacgtaacg atgatgatag atgcaactac gccgattaaa tctgcaagaa gtcccacctt 2149261 taatgcatca cccatttttt taatgccgac tgctccgaaa tacacagtca gtacgtaaag 2149321 cgttgtatct gtagatccct gcatgacgga agccagcctg ccgataaagg aatcgggccc 2149381 gtatactgca attaaatcgg tcgtcattcc aagtgcggcc gtaccggaga tcgggcggat 2149441 cagagcaagc ggcactactt cagcagggat gccgatagcg gagaaagccg gttttaaaag 2149501 atccattata aaatcaagcg cgcctgatga tctgaaaaca gttatagcga caagcattcc 2149561 gactaaatag gggataatgg aaaaggcaat ttctatcccc tctttcccgc cttcgacaaa 2149621 cgattcatat gtcggaacct ttttgatcgt tccataaaga agaattccgg caataatgat 2149681 tggaatcatg gctaaagaca gccagttgat gatttccatc cgctcacctt cccttctttt 2149741 tgcggcggta ataaaaatac cgatcaatga taatggcacc gattccggaa ataagcgttg 2149801 ccaaaatgct tggcccgacg atatctgtcg gcgttttgga ggaataagcc attcggacag 2149861 cgatcaccgt tgtcgggatg agtgtgatgc aggacgtatt aacagctaaa aaagtaatca 2149921 tcgaccggct tgcttccgat cggtttccgt tcagcttttt catttgttcc attgctttaa 2149981 tgccaagcgg agttgctgca tttccgaggc cgaagaaatt cgccataaga ttagataaaa 2150041 tatagcccat cgccgggtga tccggcggta tatcagggaa cagtttagat ataaaaggtc 2150101 tgcacatccg gctgaaaata tccaaaagcc ctgactgctc ggcgattttc attaagccaa 2150161 gccagaaaac aagcacgctc atcaatccaa atgagatcgt aatcgcttct ttcgcaccct 2150221 taaacacggc ttcatttaca tcttgcagag ttccgttgca catcgcaaaa acgagtccga 2150281 tcacggttaa actgacccaa attatattga ccattttgct ccgcctgccg cattcagaaa 2150341 gattgattta aacgtttcaa aaaattgttt cttcggtttt tgatgccgct cattttcata 2150401 atagatcggc acttttgcga tggttgcatc gttgaacatg atctccatgt gccctacgat 2150461 gtcagggatt ttcgaggcat ctttttccca tgcttttttc ggcttgagca gtgtggtatt 2150521 aatttttaca ttttcttttt cctcttcggt cagcaaatag gtgatatcac gtttgataaa 2150581 agccttcgat tcataaaatg tgcctttcag ctttggaata tccccttttt ttgcaattaa 2150641 ataggtttga taatgctcaa acacatagtt aaacatcttc atatggtcat cccaatcatt 2150701 agggtcatta atggtgacgg ctatcaggtc aatgccgtcc tttgaagccg tagagaccag 2150761 tgtccgtttt gcaagttttg tatagcctgt ttttcctcct gtgctgtacg gataaagcat 2150821 ggtcagcagt ttgtttttgt ttttccatac gctttccatc gtttccgctt tgtatatttt 2150881 tgtgcctgaa atcttttgat agtctttcag cttcatagca tacttagtta aaatggccat 2150941 gtcataggct gttgaataat gattttcatg gtcgtccaat ccgtgcgggt tttgaaaacg 2151001 ggtgtttttc ataccaagct gctcggcttt ttgattcatc atataaacaa acccatcgag 2151061 gctcccaccg acatgctcag caatcgcgac agcggcatcg tttcctgatc ttagcatcag 2151121 gccatacaca agatctttca gcttcacttt ttgaccttct gttaaataaa tggcggagcc 2151181 ttctgttctg acagcatttg ccgaaaccgt cactgtttga tccattttgc cggattcgat 2151241 ggcgaggacg gcggtcataa tttttgtgat gctcgcgatc cgcctttttt gatgctcatc 2151301 cttggcatat aacactctgc ctgacgcacc gtcaataatg atcgcgcttt ttgcactgac 2151361 atctatagca gcatgtgctg tattcacatt tacggttgca ataagaaaag aaatcatgat 2151421 cacgaatact gcttttttga aaatgcgcat gtttgctcac gtccttgtgg tggtttgtac 2151481 aagtttatgc gcatgtccat cagttatgaa taacaattat atttctggaa gcaaacataa 2151541 aaaaactctc cctgaaaaag ggagagtaaa cgttatctga ttggcgccat gcttgatccg 2151601 gacgcttcgt aatgagccag ctcttccctc atcttcagaa aggccgcgct caacggcaat 2151661 aataattgct caagcgacgc aggaacagca tgataaaact caattgcgct gaccccggta 2151721 taagacgccc ggctattttc acaccacgtg tcttttttcg gcataaagaa ctcttcaatg 2151781 cattggtgat acacattata aagtgttttt tccgctctgg cttcctgaaa aggctcctgc 2151841 atcaggagac gacggcacgc ttctgcgcct ccttcacaaa atactgccat tcttctcaga 2151901 gtgctaagca catcacagca gtatcctttt tcaataggca attcagcctg taaggactca 2151961 agcgtcgttt gatttaggta atcgttcacg gtattgacaa ccattgataa gaattcgcct 2152021 gttttttgag tctgcgctcg cacaatcgaa tgtcccattt cgtttggtat cttcccctca 2152081 tgtatttgtc tctcacattt tgcttctttc atgatagctt cttccttata tcttatgatg 2152141 atgaaaaagc gcgattcatt aaacttctat tttatatctt cgaaggtttg gttaaagttt 2152201 tcaaaaaata aatctgcttc ttcttgaaga acgtcttctt ccgcattttc aggcagcggc 2152261 ggaagctcgt ccagcgtttt cagaccgaat tgttcaagaa aagtcggcgt agtaccgtat 2152321 aaaatggccc gccccggacc atcggcacgc cctacttcac acaatagcgc cttcgcgaca 2152381 agactgtgta aaatccgctc tgattttact cctctgattt cttcaatttc tgctctcgta 2152441 attggctgtt tgtatgaaac aatggccagt acttctaaag atgcttgaga aaggcccttt 2152501 gacggcactt caatcagttt tttcaagtaa ggcgcaaagt cttttttggt agagagcatg 2152561 tacgtatctg catactcaat aagttcaatc cctcgtgtat ctccgcggta ttcgtccgcc 2152621 acatccgcca tgatcgtgtt cagttcaggc tcttcgattt caagcactgt taacagctgc 2152681 ttttttgtaa gcccttcatc gcctgccgca taaagaaggg cttccacaat agctttccaa 2152741 ttcacgatat caagccccat gaatggattc actccccgta atgtaaatat ctgaaaaatt 2152801 gtgctcctgt tcaatgagga ccagctgatt tttcatcagc tcaagaacag ctagaaaggt 2152861 cactactaaa tgttcttttt gctcatatgg aaacagatcc ataaagttaa ttctcgttcc 2152921 tctagatttc aagctgtgca cgatttcgtt cattctggct tcgattggta tgtcctgtct 2152981 tgtaattgtt gtttccatcg gcctgtttat ttttttgcgt ttcagcactt tttgaaaagc 2153041 tccgatcata tcatagaccg tgacagagag cttttgctca gactgtttta cttcttttgc 2153101 atattcactc aaatcactcg gcggtttcgt gaacgatttt tgtctttctt cttcccgttc 2153161 ttttaaatcc ttcgccgcat ctttatattt tcggtactca atcagctttt caatcagttc 2153221 ctcccgcgga tcttcttctt caagtaattc atcttcaaaa agctcctcct cttgcttcgg 2153281 gagcagcatt ctgcttttaa tgctgagcag cgtggcagcc ataaccaaat actcgctggc 2153341 aatgtcgagc tcaagcacgc gcatcgtatg tacatataat aaatattgtt cagtgatctt 2153401 cgccacaggt atatcatata tgtcaatttc aagacgattg attaaatgaa gcagcaggtc 2153461 caatgggccc tcaaacgtat caattttcac ttgatattct tccatcatct caccattttc 2153521 aagtatcact ctcattgccg gaaaaactgg ctaccctata gtataagcca ccaaaaagct 2153581 ctcgtccaat actatttcat atcctgtttt gaaggagttt gtacagaata ttcaaaacac 2153641 aagaggtgtt tgctcggagc gcagaagcgg gagaaaaagc ctttgcttct ggttttcctt 2153701 tctaagaagc actagaggcc gggcgttctt ttttcctttt atcccttcta tggtacacta 2153761 aaagcacatt aaaggaggaa gcaccttgta tccgaaagct tatatagatt atctcgttga 2153821 gtttcatgcg acacgggatt attttgaatg ccatgaaata ttagaagaat attggaagga 2153881 agatccgcca aagaaacgaa aacgctattg ggtgggcttt attcagcttg cagtggcttt 2153941 atatcatcac agaaggcaga atacagccgg ggcaaaaaga ctgatggcga acagcatccg 2154001 gattcttcaa gcagaacacc gggcagtcga agacttaggg cttgatcatg gccgtttgct 2154061 cgaacttatg caatcggttt acgaacaaat cgaaaccgtc tctgcctata aaagcattat 2154121 actgccaatc aaagatgaga aactggagga agcatgcagg atcgaatgca ggaaaaaaaa 2154181 gtatacatgg gggcagccca gtgcactcag caacatattt cttatcgaca aacaccgttt 2154241 gcgggatcgg actgacgtca tccgtgaacg tgaaaaagaa atagaacgca gaaaaaaaag 2154301 cagagactga tcacagcctc tgcttaatta ttgtatgaaa tgtcttgatc ctgctgacct 2154361 tgacaacgtt cgaaaaagct ctgcgttaat tcatttggaa ccagtacttg cgttttgaat 2154421 aaatgcttta aagcatccat catctgtttt ccgattcctt gatggcgatg agaaggattc 2154481 acactgatat gccggatctc aacctcagaa tccttttttt cgactccgat tgctccgacg 2154541 atatcctcgt cctctttcca aagaaagagc tggcggtctg tatccgtttc gtagtcctta 2154601 attgtctgct gaagctgctt aaggtctttt tcattcggca taaacgaaag aagccccatc 2154661 gcaatctttt caaacgattt tttataacga attaacataa aaacccctct atatccaaaa 2154721 tgtccagtct gctattaacg gatacgaata ggtgatccgt tttctcacat tatatcattt 2154781 tcgccatatt tttaaactgt tttcagcaaa ttattcaaat gagcggttta aatttgccat 2154841 ttcaatggca gaaacagcac aatctacacc tttgttgccc gcttttgtgc cggcacgctc 2154901 gatagcctgt tcgatgtttt cagttgttac aattccaaag atgacaggta caccagtagt 2154961 gtttgctgct tgcgcgatgc cttttgcagc ttcattgcag acataatcgt aatgtgtcgt 2155021 tgcgcctctg atgacagtgc ccaatgtgat aatagcatca tatttttttg tttccgccat 2155081 ttttttcgca gcaaacggta tttcaaatgc gcctggaacc caagccacat caatgtcatt 2155141 tgtgtctacg ccatgtctga gcagcgcatc ttctgctccg ctcagcagct tgctcgtaat 2155201 aaaatcatta aatcttccta ctacgattcc gattttaaga cctgtaccaa ctaaatttcc 2155261 ttgtatgata ttcatatgat tcccatcctt ttttgtgata tttgtgatta gaaatgaagt 2155321 aaatgaccta gcttgttcat tttggtttgc aaatattttt tattgtgttc tttcgcctcc 2155381 atttgaagcg gcactctttc tgaaatactg agtccgtagc cttcaaggcc tgcgattttt 2155441 cgcggattat tcgtcaaaag cttcatattc cggacaccga ggtcgcgtaa aatttgtgct 2155501 ccgatgccat agttgcgaag atccggcaag aatccaagcg cctcattggc ttctacggtg 2155561 tcatagcctt gttcctgaag cttataagct tttaatttat tgattaaacc gatgcctcgt 2155621 ccttcttggc gcaagtacag gagcactcca cggccttctg cggcaatttg gttcagcgcg 2155681 gcgtgcagct gcggtccgca atcacagcga tgagagccaa acacgtcacc tgtgagacat 2155741 tctgaatgca cccggaccaa taccggttct tctccgaacg gcacatctcc catcacaaat 2155801 gcgacatgct cttttccatc tacctcattt gtgtatccat aaaccttaaa tgtcccaaaa 2155861 tcagtaggca gcgtaatgtc aacttcacgc tcgacaagtg ttgtcagatt gtaacggtat 2155921 tgaatcaaat ccttaatggt gatcattttt aattgatgct ttttcgcaat ttcaatgagc 2155981 tcaggcactc tcgccatcgt tccgtcttca ttcataattt cacaaatgac gccggctcct 2156041 ggagatccgc aagcttcagc aagatcaaca gcagcttctg tatggcccgc tcttttcagg 2156101 acacctcctt ttttcgcaat cagtggaaaa atgtgccccg gacgctgaaa atcagatggc 2156161 acggatttgc tgtccagcaa tgcttgaacg gtaaaagatc tttcttgagc gctgatacct 2156221 gtcttcgttt cacgatggtc tatgcttacg gtaaatgcag tgtggtgaga gtctgtatta 2156281 tgctcaacca tagggtgaag atcaagcctg tctgcgattt cctcactgag cggcgtgcag 2156341 atcagtcctc tcccatgtgt cgccataaag ttaatgactt ccggcgttgc atgctcggca 2156401 agagccacaa agtctccttc attttctctg tcttcatcat ctacaacgat gatgacttcg 2156461 ccttttttta aagcgtccag tgcttcttct atcggatgaa acatgcaaat cttcctctct 2156521 aaaagccgtt ttcgcttaag aaggcttttg taatggtttg ttgggtctta ttttcattgg 2156581 ctttatgcaa aaatcgatac atatattttc cgatcatatc gcattcgata ttcactttag 2156641 agccgatcgt tttttctgaa aagatcgttt cgctgatcgt atgcggtatt aaggagatcg 2156701 tcactgtgtc ttctgtcagg ccgaatatgg ttaagctcac gccatccaca gtaattgatc 2156761 cctttaaaac caatgttttt gttaatgacg ggtccatttt taaatcatag taaactgcgt 2156821 tgcttttctc ttcaattcgt gtgatttccg cagttccgtc gacatggcct gagacgaaat 2156881 ggcctccgaa acggccgttt gccgccatcg ctctttccag atttactttg cttccttttg 2156941 ttaaatcatt cagtgacgta gctttgactg tttcaggcat aacatccact gtgaattgat 2157001 tttttgtaaa atcagtgaca gtcagacaaa tgccgttcac tgcaatgctg tcgccaagat 2157061 gaacatcctc taaaatcttt gagcatttaa tagttaaggc cattgcatgc cctgcttttt 2157121 tcatggattc gattgtgcct gtttcttcga taattcctgt aaacatggtc accatcctat 2157181 tcctttgtcg gttttgccgt cagtttgata tcacggccga tttgggttat atcagtgaat 2157241 tgtaataagg ggacatcttt cattgattga aaaccttcac cggagattaa gctgggagca 2157301 tgcgttcctc cgattagttt aggggcaaaa tagaagatga tttcttgaaa acagccttct 2157361 ttgacaaagc ttccgtgaac agctgaaccg ccttccacat acaccgacat gatgccttct 2157421 tccgctagga tcttcaaaac atcaggaatt tgaatgcgct cggtttcaag tgtaaatatg 2157481 ttcactccga aagctgaaag ccgttttttc ttttcctcgt ctgcgcgtgc cgtcgtaaaa 2157541 atccatgtcg gcgctatttg atcgcaaatc actttagcgt cctcaggaat cgagagtacg 2157601 gtatcaagta tgacccgaac cggctgtttt gttacattcg gcagtctgca ggttaagctc 2157661 ggattgtcgg ctttcactgt gccaactccg actaaaatgc tttggtgtgt tttcctgtat 2157721 tgctgagcat cctgtcttgc agcctctgac gtgatccatt tgctgtcacc cgtgctggta 2157781 gctatcttgc cgtcaaggct ggcagccgct tttagcgtga cgtacggaag gcctgtcctc 2157841 ataaagtgca gaaatttttc attcagcctc tccgcctggt ctgccaggat gccttccctt 2157901 acctcaatgc cagcttcttt catcatgctg atccctcttc cagccacaag cggattagga 2157961 tctctcatcg ccacgaacac tcttttgata ccagagttga taatcaattc tgcacatggc 2158021 ggtgtttttc cgtaatggct gcacggttcg agtgtaacgt aaatgtcggc accctctgca 2158081 tgtgctccag ccatatggat ggcatgaact tctgcatgag cttcaccata ttttaaatgg 2158141 gcgcccattc cgacaatttg tccgtccttt acgacaacag cgccgacgag cggattggat 2158201 tcggtctgtc cttcgccctg cttcgcaaga tctaaggcca gcttcatata atactcttcc 2158261 atttgtttcc ctcccctctt ttgttattta ccgtcaaaaa agccccgaat ttataaaaaa 2158321 ttcggggctt taggtatttt acgcaatagg aaataacact atgcattttt aaacattttg 2158381 catagcggct catcatcctt ctcccatcca gactttcact gtcggcttca gcttaaactg 2158441 aatccaccgc gtgcttatgc acacgggtca cgggctctaa agcaaatgtg ctttactacc 2158501 gccggtcggg atttccaccc tgccccgaag gatacaatct ttattcattt gtccttattg 2158561 gttattatag cgatcctttt taaagtacgc aatgaaataa acttacaatt tgagaaaaac 2158621 aaaacatcac ccttcgatcc gaaaggtgat gttttttaat cattcacttt tgcaaccttg 2158681 attaatccgt cgatccgctt tgatttgctg aagtaagcct taatcttgtc accttctttt 2158741 atatcagata aatcctgatt taattttttt ccgttgaaga tgattttcgt tccgttttct 2158801 gctactccat gatactctga gccgtcaatt ttcgtcactt tatattcctg gatggtgtat 2158861 tcctcttctt ccgaggacaa ggtttgtcca attgctgtcg gaacatcctt cagctcaata 2158921 tcatttatgt acatataacc gcctgcaagt aaaagcaaaa gcactaacag aatggtaatc 2158981 ttggttttta ttcttcccat ttctaaacct ccagccaata tgaatctatt cattcatatg 2159041 agttattcct ttttttcatg aataaaaaac cgtaaattct cgtaaattat taatataacg 2159101 atgcataacg ggaatatgtt tcacatttct gcaaaaattt cttttctata gatatacgaa 2159161 tttatgttct gtttttaggg gatgaccgta aaaaagatat aaaaaaagca gccccaatgg 2159221 gaagctgctt gatcctaatt tgttttgcgc atttcgttaa acgggtagaa aacaaacttt 2159281 gacgtacccg caatttgttt tttcgtgaag aggccaaggc cgttacggct gtccatggaa 2159341 ttgcgacgat tgtcacccat cacaaaatac ttgttatcag gcactttaac cgggccgaaa 2159401 tcatcggtca aatggtcaaa accgtcctgt ttcgctctct ttttattagc cgccaaataa 2159461 ggttcgtcca cctttttccc gttgatatag agctggtcat ttttcatctc aaccgtatcg 2159521 ccgggaaggc cgataatacg tttgacatag tgaacatcat ctccgtttaa cacgacgatg 2159581 tctcctctat caaactcgcc gatgtatttg actgtcatat taacaaaaac cctttcacgg 2159641 ttgtgaagtg taggatacat agagtcacca tcaacgacat acggcgcaaa aataaagttg 2159701 cggatgagca aagcaagaac gacagcaatc acaattgctt ttgcccattc taatattgac 2159761 tttttcttcg aaacattttc tgatttcaac tgatttcctc caataaacaa cggtcttcaa 2159821 tttatgttat cacgaatcga aaaaaaatcc cattaggacc attgaagtga ttttacaaac 2159881 tgttaatctt catcttctac ccacatcatg cctatttttt cttgtcgatc ataactaggc 2159941 ctgaaaatat tgaaagaaat gaatcgcata attcagaagc gatggactca gaagaaagag 2160001 agttctcata tgcaaaatct ttagatcgta tataaagcat gaggttacgg gcagtttgtt 2160061 catttactgc attccattga tctcccagtc catgataccc atggcacttg acaaaacaat 2160121 taacgtcatg aaggttactg gaatgtttgc ggcaacctat ttcacaggtg ataaccgcac 2160181 cccgtttttt gctttcataa tatgtttaaa atcattcaag ctcgaaaaca tggatcagcc 2160241 tccaaaaaat aaatccaata tattcccggc agttgaagac tctttattat aaaactctga 2160301 atatccgcag ttcttacagt aaaccactag aaatcggtta tgctgcacgt caaacagctt 2160361 tgataatccc gtgccggttg tagctatttc tttttgtccg gcttcagtac taccgcattt 2160421 tatacagcct ttgttgttca tatcgcgatc tccttttcat tacatcacgt ttgtttgatt 2160481 tattttacta caaaatatca atcccaatga cccgtactac tttaaagttt acttaatttt 2160541 gattacatac taattgggtt cgtttctcag cttggtaaat cttctggaga aacggaaaag 2160601 ctccatgacc aaaacattca aactcagcca aacaccgccg aaggcgtaac ccgcagcaac 2160661 atcactcgga tactgctcat aaagtacaca cggctcagcc cgatgaggaa taaaacgata 2160721 ataaacaaaa aaatgcaaca gtttgcagac gcgtcttgtg agaatgacga acaaaaagat 2160781 aagcacaaaa accaaaaatg acaaatgccg ttaaagtctg ttcgctcggg aatggatata 2160841 atacatgact ttccaaagga gcgtgaacag gatgaaggga atgaaagagc cgtctgattc 2160901 cctcttcata aagctcccca ccaatgacta ggaaaaataa gaaagagagt tcgattttcc 2160961 gatcttgccc tctgaatacc gtccaaaaaa aagttagaac aataacggct aacagaacac 2161021 ctctcgacgc aaaagctttc tgaattgcag ctgggcccag tctatacccg atccaatacg 2161081 acatgctcac tcccacagct ccccaatccg gccgctaaca tgcttagcac ccagtttaac 2161141 ttttcttgaa acacgagaac accggcaaac tctcccggtc caagtaaagc tagaagctct 2161201 aacatcaaga caataaacaa gacggcatat ccgtactgtt cgagcaaccc cgtcaaaact 2161261 tgcatgtgat tctccttaaa cttttttgtt cttttatcat tcccaatcca ctttttgtat 2161321 aatcagcaca attttatctt cagtcgtcca acaacattgt ctatggcggg atcttctctc 2161381 atacattctt ttttgacata ggaggagcaa tagcatgaaa tgggaggaaa caaaagatac 2161441 gcagggagtt tgccaaaatt ttgggcagtt cgttctgcca ccgagtcagg tgtttgtttg 2161501 cccacctcat cccttgtcaa ttccccattt ttcccgtttg aggttcgaaa tggtaaagta 2161561 tttcacttag tttcttacat gaagaggtaa attctttgct caccgaacta ggatagcggc 2161621 gtatggcgat ttctacattg cataaccact ggttatttag tgagccgtga gcaatgtata 2161681 tgcactttga gtcagcacag gatgatccta ttacattcgc cagaaaagca gctgccgcat 2161741 tcagagtagt taaaagaata gacagatatc tgggcttccg gaagctttaa aggaggctct 2161801 tttttcgagc atttttataa atcaataaaa acaggcatct cctaaatatt tttgccgata 2161861 agtttacgct aatcaactct agcactaata catataaaaa atagaatgat atgaaaggag 2161921 acttgatagt atgattgatt atcctattaa tataaacaac gtttccggga acagtgtaat 2161981 taacgtaggc ggcgctttta tgatcaggcc tttaactttg tccaaatctg tgtttggctc 2162041 cggaggttta aacacaggaa ttgtctttga aaataacttt gtaagcaaag ctaaaatgat 2162101 taatcatcaa tttactgatc aaaacgtcac caaaactttt taatgtattc aatacacggg 2162161 ggtcactaac taaacacctg gttttgccaa ccgccatcag cattcggcgg ttttttattg 2162221 aacatttttg gccaataaaa aaagcttcct ctctaagagg aagccttttg cctgccgatt 2162281 agccttctac acgaacttct ttcatgacat cgccattaga catgtttttc gcgaattcta 2162341 atccgcttgt tactttacca aatacagtgt gaacaccgtt caaatgaggc tgtggctcat 2162401 gaacgatgaa aaattggctg ccgccagtgt cttttccggc atgtgccata gaaagtgcgc 2162461 ccgcctcatg tgtatgcggg ttgccttctg tttcacattt gattgtgtat cccggaccgc 2162521 ctgtaccagt tccgtgcggg catccgcctt ggctgacgaa gccagggatc actcggtgga 2162581 atgtaagccc gtcataaaag ccttcgttcg caagcttttc aaagtttgca acagttccag 2162641 gtgcagcttc aggataaagt tcaaattcaa ttttgttccc gtcttctaat aaaaagtaac 2162701 ctgttttcaa ttgtatgcct actttcttta ttttaatttt caaaggagat tatgtatagg 2162761 ttatagcctg tctctccttg tcgcggctat tataccacac ctttcggggg aaaacgaatc 2162821 tcccgagctt tactaaaaaa taaaaatgaa acctgaatct ctttatctcc gtctaaccta 2162881 acggaactgt atttttcatg attcaggtcc tcacaaagca gcactatcca gctgcttgtg 2162941 aaattgaagg aggtcaaact gctttgaaga aaatttggat tggaatgctg gcagcggccg 2163001 ttttgctgct gatggttccg aaggtcagtc tcgcggatgc cgcagttgga gatgtcattg 2163061 taacactggg tgctgatttg tcagaatctg acaaacaaaa agtgcttgat gaaatgaatg 2163121 tccctgataa tgccacaacg gtaaccgtga ccaataagga agaacatgaa tatttaggaa 2163181 aatatatatc gaacgcgcaa atcggatcga gagcgatttc ttcatcgtca atcaccattg 2163241 ccaaaaaagg ctccggattg aatgttgaga cccataatat cagcggcatc acagatgaaa 2163301 tgtacctgaa tgcactgatg acagccggtg ttaaagatgc gaaggtgtat gttacagcac 2163361 cgtttgaagt atccgggact gccgctttaa ctggattgat taaggcgtat gaagtttctt 2163421 ctgacgaagc gatctcggag gatgttaagc aggtcgccaa ccaagagctt gtcacgacat 2163481 cagagcttgg agacaaaatc ggtaacgaaa atgcggcagc cctgattgca aaaatcaaag 2163541 aagagtttgc taaaaacggg gtgcctgata ataaagctga catcgaaaaa caagtggatg 2163601 acgcagcttc tgatttaaac gtcacactta cagacagcca aaagaatcag cttgtctccc 2163661 tattcaataa gatgaaaaac gctgacattg actggggaca ggtcagtgac cagctagata 2163721 aagcgaaaga taagattacg aaattcatag aatcagatga aggcaaaaac ttcatccaga 2163781 aagtcattga tttcttcgta tctatctgga atgcgattgt atctatattc aaataagaaa 2163841 agcgccgaaa aatcggcgct ttcttttatt gctttacacc cgttttaaat ggcagatcaa 2163901 gttttacaat atcttcgtat gtttctcgct tcacgactaa atgagcctca ccgttttcga 2163961 caaatacaac ggcgggtctc ggaatacggt tataattgtt ggccatgctg tatccataag 2164021 cgcctgtaca aaaaacggca agaagatcgc cttcttttac ttccggcagg tcaatatccc 2164081 aaatcagcat atctccgctt tcacagcact ttccggcaat tgataccgtt ttgtcatgcg 2164141 cttctccgat cctgttggct gccgcagctt catatttagc ttggtaaagc gcaggacgaa 2164201 tattgtcgtt catgcctccg tctacagcca catattggcg gacacccggc acttcttttt 2164261 gagagccaac cgtataaaga gttgtgcctg cgtctcccac gagagaacgg cccggttcga 2164321 tccaaatttc cggaatgtca aaaccgtaac gggaagcatt ttctttcaca gcttcgataa 2164381 ttttttcaac gtattcagtg gcatgaagcg gttcatcatc ttccgtataa cgaatgccga 2164441 aacctcctcc aagattcagc accttggata caaatgaata tgaatctctc cattcgtcta 2164501 gttttttgaa gattttttcc gctgctaaca caaaaccggc cgtatcaaag atttgcgagc 2164561 cgatatggca atggacaccc agcagctgaa tgtgttccga ttgtaatact tgttcaatgg 2164621 cccgttcagt ttgtccgtta tgaagatcga aaccaaactt tgaatcttcc tggcccgttg 2164681 taatgtagtc atgcgtatgc gcttctactc cgggcgtgat ccgaagaaga acatcgatgg 2164741 agtgacccgt ttctttacat aggtcttcaa gaagcgcgat ttcatagaaa ttatccacca 2164801 caatgcagcc gatgcggtgc tcaagcgcca tccgcagttc ttccctgctc ttattgtttc 2164861 catgaaagtg gatgcgttct gccggaaagc ctgctgcaac agccgtatat agctctcctc 2164921 cggatacgac atctaaagaa agtccctctt cctcagcgag ctgaatcatt gcgactgatg 2164981 agaatgcttt gctcgcatat gccacctgtg ctttcagccc tgcagaaata aacgcctgct 2165041 taaagctttt agcacgctca cgtattaaag ccacatcata tacgtaaaga ggtgtaccat 2165101 atttctccgc taaatagaga gcatccacac ctccgatttc taaatgacca tgttgatttt 2165161 gtctgcttgt gccgtgtaag aacaatgtca ttccctcttt ctccgcttat ggatgaaagg 2165221 acagttttat ggactgtccc ttcataatta agacatacat tatcatactc ttcagtcagt 2165281 ttcaatgcga ttatgaattg gtaggctgcc ttaagcgatt tttggggtga acgatgctgg 2165341 gtcttacttt tgcgccaggt ttcgctgtgc ggacaagaac ctgccacagc gcctttccgt 2165401 taaagggaat cagcggccat aagtacggtg tctgaaggga tttgatgctt gccatggcaa 2165461 taattagcac tgtaaatccg atgacgagcc cttttatatg aaataaagca acgagtatca 2165521 tgaggacaag acggctcatt ttgtttgcca agcttaattc ataactaggc gtcgtaaagg 2165581 ttccaatcgc cgcaagtgag acgtacagaa tcacctcagg agaaaaaagg ccgacctcaa 2165641 tcgcaatctg cccgatcaga acagcggcaa ttaaacccat tgctgtcgat aaagccgtcg 2165701 gtgtgtgaat ggcagccatt ctgagaaact cgattcctaa gtcagctaaa aatatctgca 2165761 ggatgatcgg gatatgcgta tctttattta aaccgataaa tttcatgttg tccgggagca 2165821 gatcaggctg aagcacaaag agaaaccaga tcggaagaaa taaagtagaa gcaagaatac 2165881 cgaaaaatct tacccatctt aaaaaggtcc cgactgaagg cgcctgccta tattcttcag 2165941 catgctgcac atggtgaaat aaagtcgtcg gggtaatgat cacactcggc gatgtgtcca 2166001 ctataatgat aacatggcct tctagaacat gatttgcggc cacatccggt ctttctgtat 2166061 agcgcacgag cggaaaagga ttatagcttt gattaacaat gaattcctcg acagttttgt 2166121 ctgccattgt taatccatcg acatcaatgg atgcaatttc tttttctacg atctcaacca 2166181 gatccggatc agctatatct tctatataac aaatgcttaa atccgtcttt gaccgctcac 2166241 caactttagt catcttgact cgaaggcgtt cgtctctgat ccgccttctg agaagggccg 2166301 tattgacgac gatattttca acaaatccgt ctctggctcc cctgaccacc ttttccgtat 2166361 caggttcttc cgggtttctg cccggatagc ttctgacatc aattataaat gcgaagcctg 2166421 caccttcaac aatgacagcg acgagcccgg acagcacttg gtcggtggtt tcatccaagg 2166481 tttttacttt ttcgacctgg gcgttaagca gcctgttttc gacgatgtcg accagctcat 2166541 cagggtcttc tttccgattg ttaatggcaa caagctctct cattaaatga ataatatagg 2166601 ctgtatcgca taatccattt agatagtaaa gctggatctc tttatctaaa atcgtgagct 2166661 tgcgaacacc tacatcatag ctcgtcccca tcccaacacg gtttttgaaa tactcttcat 2166721 ttttagctgg attccgataa acccgaattt tctcttcctt gtggtccggc atgatacccg 2166781 ctcctttcta aaataaactc gaccgctttc atggtgattg gcgacccttt tgagatatcg 2166841 tcttttctgc ccattttgcc gatatccccg ataccgacaa taagcgggag atcaagttta 2166901 tcaaggcaat agactgtatc tccactcatt ctgtggtcat caaattccct ttccccgact 2166961 ttatcgacgc cgtattcagt tatttctcca ttgcggtcaa tgcttacatc gaccctggtc 2167021 cattcagcct gatgtgtttt tgacgcgacc gcaatcacac cgagcacttc aatagacgga 2167081 tgggttgcga cataggttag agcggcttct cccgggccct ctccttgaag gccggagtcg 2167141 tcaaacatga caaatacagg atcatacggt gctgaggcga tcagcttgac aagctcggcg 2167201 ccgctgcggg tggaaggatt cccttttgat tgtgaaatac atcggcctcc cactttgctt 2167261 gcggcgtatt caattgtttt agcggcataa acatccccgt ctgttaccag tatgaccttg 2167321 cgttttgtcg tcatgtcggc attatccttt cggtttgaaa ataacagcta cgataaaggc 2167381 gaaaagaata gcggctgaga taccggccga ggtcagctca aaaatcccca tgccgattcc 2167441 gataaatccg tgtatatgcg cctgatgcat ggcgccgtgc agaagactgt gaccgaagct 2167501 gacgatcgga acggtggcgc ctcctccggc aaattcaata aatttatcgt aaatgccgaa 2167561 accatctaat attgcaccga ttacaacaaa tgatgtcatg acatgagctg gcgtcaattt 2167621 aaaaatatcc aagagcagct ggccgacgat acagatggcc ccgccgcaga caaaagccaa 2167681 aaggtagtcc atattaagat gcacctcctg cacgctcaaa tacaaccccg tgggcgatag 2167741 tcgggatggt ttctttttgc tggatcatcg tcgggcttaa tagcgccccg gtcgccacga 2167801 caaatacacg gtttagtttt ccttctctca gctgcttaaa aatatgagag taggtgacaa 2167861 ccgctgaaca agcacagccg ctccccccgg caaagacctg ctgatccgga gtgtaaatca 2167921 gaagcccgca atcatcatgc tttgtgccga ctggatatcc atcttctttt aaaatgtctt 2167981 ttacgattgg agaaccgacg cctgacaggt cacctgtcag gattagatca tagtcatccg 2168041 ctgtccggtt gagatcttta aagtgctgct taatcgtatc agctgcagcc ggagccatag 2168101 ccgatcccat atcaaaagga tctgtaattc ctaaatcaga aaccttcccg acagtcgcac 2168161 ttgtgatttg gatatcaccc ggtgtctgac tgatgacaac tgcaccgctt ccggttacag 2168221 tggaggtagc agtgtccggt ttttggcctc cgtattctgt cggatagcga aactgtcttt 2168281 ccgcagttgc attgtgactg ctggtggcag cgagtgccct tttggcaaac cctccatcaa 2168341 ctaaggctga tgcgacagcc actgtttcca ttgatgttga acaggcgcca aacatacaaa 2168401 gaaatgggat tttcaagtgt cttgccacat agttagccgt cacgttttgg ttcagcaagt 2168461 cgcctgccag caataggtca atatcatctt ttgtcagatt gtttttttga agtgcaacat 2168521 taacagcgtc ttccatcagc tgccgttccg ccatttccca gcttttttga ttacaatgca 2168581 tttcgtcata ggttttatca aataaagagc caagcggtcc gtctttttcc tttggtcctg 2168641 ctgccgttcc cgctgagttg acaaatatgg gatgttcaaa tacccaggtt tgctttcctg 2168701 ttaatttcat tttcttctcc tcctatgaca tcagtttctc aaaagcaaac cgaatcattc 2168761 caacgatgta tgcagctaca actccgaaaa caataacatt tcctgccagt ttaaacatat 2168821 ttgtcgctac tccaagcact aatccttcgc ttttatattc aagagccgca cttgccatac 2168881 tgttggcaaa acccgtgaca ggtacggctg aacctgcgcc tgcgaattgt ccgattctgt 2168941 catagattcc aaaccctgta agcagggcag aaattaatat cagcgttgca gctgttggat 2169001 tccccgcagt tttttcattg aaatcaaaaa aatggatata aaaattttgc agaccttgcc 2169061 cgattgcaca aatcagtccg cccactaaaa aggcttttac acagttccag acgtaaggcg 2169121 gcttaggctg atatgttttc acttttgatt tgtaattttc ttttatgttt gtcatcttga 2169181 aacctcctta tgaatggtca ataaagtaca gccagtgaaa taaagatccc gcgattttcc 2169241 caatcacgat ggccattaac agaataatga ttttacttct gagcccgatt cgtttcgcca 2169301 aaatcggcag gacatttaaa acctctgtaa gagcagccgc tagcatcccg acgaacaaac 2169361 ctgccagaag cccgaccggc acagctatcc attttgttag ataaagatga ttcatatgaa 2169421 gcgtctccca tcccccgcaa accgcgccaa gaataacagc cgcttcataa gcctgaacaa 2169481 atctcattgt tttggtgagc tgcatcagcc gcggaatgat tcccattacg gttaaaaaag 2169541 caacgaaacc cgcccccacc gttatgcctc cgccgagccc gacaaaaatg atgaacaata 2169601 cactaacgat catgcagatc ctttatggtt tcttgattct catgcatggc cacatattga 2169661 tcgagatcaa gctgatagtt aaacatctca acctccagcg ggctgggctc ttcatttagg 2169721 cgctttttaa atatgtggtt aaaaaacacg atcatcccca gtcccaaacc gatgctgtat 2169781 gggatttgaa gcaaatatgg atagtcattc ctctctccgg ttatgatttc atatagtgcg 2169841 atatgaacat ctctcatgct tacatcctca tgaaagttca tgatggcaag acacgatcca 2169901 ataaacagaa gcagccagac accgataaat agaaccgttg ataaatttcg ctttcgatac 2169961 tgaatttcaa caatggtttc tgctccgcct acggtttgaa catcaattgt cgggtcttgt 2170021 aaatgaatgg ctctgaggac ttgtatgata tccagaatta cgatattttt atctttttcg 2170081 ctcacctgat aaagcggcat agccgaaagt ttctttttca gctgaagctg cccttctatt 2170141 tgcgcggcat ctccaacggt aataatatcc cctggatgtg ccagcactcg gtggcgaagc 2170201 cggataaata ttcgtcgttc catcattgat caccatcttt cggtggttat atatgtagta 2170261 tgtggttcga ttttgttctc attcatccgc tcgaaaagac cataaattac cacgcttttg 2170321 cacaaaaaag ctagcctgca ctgcagacta gccatccgta tgatccattt gaaccttgat 2170381 ctgttttaat attttctttt caagcctgga aacctgcacc tgagagatcc cgagccgctc 2170441 agccacctcg gactgtgtct ggtctttata atatctgaga tagacgatta gtttttccct 2170501 ttcctccaaa tcgctgatcg cttctttcag cgcaattttg tcaaaccatt tttcttctga 2170561 gttgtcagcg atttgatcaa gcagggtaat cggatctccg tcattttcat aaacggtttc 2170621 gtgaatcgaa gatggagccc ttaccgcctc ttgggccagt acaacatcct cagcttcaat 2170681 ctccaaatgg tcagcgatct cctgcaccgt cggcactctg cccagtgttt tcgaaagctc 2170741 atccttcgcg cgccggattt tgtttccaag ctcttttaat gaccgtgata cctttacggt 2170801 tccgtcatca cggataaatc gttggatttc tccgataatc atcggcactg catacgttga 2170861 aaaacgcaca tcataggtta aatcaaattt gtcaacagat tttaacagcc cgatgcagcc 2170921 gatctggaag agatcgtcag gctcatatcc tctgtttaaa aaccgctgta cgacagacca 2170981 aacaagacgc atgttttttt ctatgaggag gtctcttgcc tgctggtcgc cattttggct 2171041 ttgtttgatt aattccttta cttcatgatc cttcagctga gcgtttttgc cgtttttctt 2171101 aacctccaca tccataacaa atctccttaa ttacaaagcg ctttgctttt tgataagtgc 2171161 tttgttaagc gaatcgttgt tcccatttca ggcgatgaat cgatactgac atcatccatg 2171221 aaattttcca taatggtaaa gcccattcca gagcgctcaa gctcaggctt agtcgtaaat 2171281 agaggctgac gggcttcttc aagatctgta atgcctaagc cttcatcacg aatagtcata 2171341 tatacgacat gatcttccag cgtcactgaa atgtaaactt tcccttcaca gttctcttca 2171401 tatccatgga taatcgcatt cgtgacagcc tctgacacga ctgttttgat ttcagtcagt 2171461 tcatccattg tcgggtccag ctgagctata aatgaagcaa ctgtcacacg ggcgaacgat 2171521 tcattctgac tgagggcaga aaactcaagg tgcatttcat ttttcatgat gccaccccca 2171581 gtgtcaggag tgcctgctgt tcagattgtt caaatcggat aattttaaac agacccgaca 2171641 tatcaaacaa tcgcttcacc gcaggagaga tagcgcaaac aaccatttct ccgccaattt 2171701 gcttaatttg cttgtatctt cctaaaataa cgccaagccc cgagctgtcc ataaaggaaa 2171761 ggtcctccaa gttcagcacg atatggcgaa tatcatcctt ctccaatgat tgagtcactt 2171821 tttgcttcag ggtttcagcc gtatggtgat cgagttcgcc tgttaatcga atacaaagca 2171881 cagattcttt gacattcatg tcaattccaa ggctcatgct cattcctcct tgatatgatc 2171941 ggataatgag tgtttcgatt tcgacggaat gaattccttc accgtgacaa aactagtggt 2172001 cattcggcat aattacttaa attttgtcca gtctcccatc gtccgcttta agaatgtgat 2172061 aaacccggct ttcttcatat cttcttttgc agcaacagga ctttcagcga gtacttctcc 2172121 atcctttttc agaacaagag tgccaagctc ttggcctttt tgaatcggag cactaatatt 2172181 gtccttcatc ttgatttctt ttttcacatc gttcatatcc tcgccttttt tcgtcaatat 2172241 tgaaatcggc tcagatgtag tgagttcgat aaatttttgt ttcccttttt tgacctttac 2172301 ttttgctact gtttgatttc gtttatataa aggatgcgtt tcatattggc taaaggcgaa 2172361 gtcaagcatt tttgtcactt gcgcgtttct ttctttaggc gtgctcgctc cgaatacaac 2172421 cgctatggcc cgcatgtttc cttttttagc cgaagcagtc agacaatatt tcgcttcgcc 2172481 tgtatagcct gtttttacgc cgtctacacc aggataaaat ttgataaggc gatttgtatt 2172541 tacaagccaa aactttttat ctgtattttc acgcagataa tcttcatacg tgccggtaaa 2172601 cttcgtaatt gattcgtatt tcaataattc cttagccatg attgccatgt cataagcaga 2172661 gctgtagtgt ccttcctcgg tcagtcctgt tgggttttta aaggatgtat ttttcaatcc 2172721 cagctctttt gcttttttat tcattttctt cacaaattct tcttcagagc cggaaataaa 2172781 ttcagccatg gcgacggaag cgtcatttcc cgaagcgatt gcgatgcctt tcagcatttc 2172841 tttgacagtc atttcttcgc cgggctcaag gaatatctgt gagccgccca ttgacgccgc 2172901 atgctcgctt gtacggacct tatcactcat tttgattttg cctttatcta aagcttccat 2172961 aatcaaaagc atcgtcataa ttttcgtcat gcttgcaggc gccagtctct cattgctgtt 2173021 cttgttgtaa agcacttttc ccgtgtcacg ttctatcagc accgcagact tcgcttcatg 2173081 agcaagctcc gatgtacgtt ttccgtcttg ttttgcaaat gcagacggtg caaatgtaag 2173141 cagcattata ccaatcaaca aagtggataa aagacgtttc atctcaaaag ccctccattt 2173201 cataatcctt tttatttttt ccaagcgtga tggttttata cgccactgat ggaaaatgtt 2173261 tcgaattttg ggcataaaaa aagacagctg tgtgatatca gacacagctg tcttttggtc 2173321 ctgcattgat tcatatttat tcgtactgag cgacgatcgc tttaacaagc tttaagaatc 2173381 cagcttttac tttttcggtc acttccataa cttcatcgtg acttaaaggc tgatccagaa 2173441 ttccggctgc cgcgttagag atgcaggaaa tgccaagaac ccgcattccc gcatgattcg 2173501 ctacaatgac ttccggaaca gtagacatgc cgactgcatc agagcccatc gttcttaaga 2173561 aacggacttc tgccggtgtt tcgtaagaag gtcctgtcac agcagtgtac acgccttttt 2173621 gaattgggat attaaggtct ttcgcaatct tttcagccag gctggacaga tctttgtcat 2173681 aggctgaaga catatctgga aatctggcgc cgaaatctgc ttcgtttggc ccgattaacg 2173741 ggtttgttcc cataaagttg atatgatcgg taataatcat taaatctccc gcacggaatt 2173801 cagtgttgac accgcctgcg gcatttgtca cgatcaacgc ttccacaccg agcgctttca 2173861 tcacgcgtac agggaatgtg actttctcca ttgagtagcc ttcataaaaa tgaaagcggc 2173921 cctgcattgc aatgacggaa actccttcaa gagtgccaag cacaagctgt ccggcatgcc 2173981 cttcaacagt agataccggg aattcaggta tatcttcata tttcagcttg accggatttt 2174041 cgatttcgtc cgccaaaatg ccaagacctg agcctaaaat aaggccgatc tttggagatt 2174101 ccggcaggtt ttgtttaata aaagcggctg cgcgttcaat tctgtccttc aagaaacagt 2174161 ccccctattg taataaagat aaaaagcttt tcccgtattt cggtttattt gtttggaaat 2174221 tatcagcgat cgttgcgcca atatcggcaa atgtatctgc aagcggcagc atttgcgctt 2174281 tcttatgttt tttgctgtaa gcgagaatcg gcacatactc gcgtgtatgg tcagtcccat 2174341 gatgaatcgg atcattgccg tggtcggctg taataattaa cagatcgtct tctctcattt 2174401 tttcaaacac ttccggaagc cgcgcatcaa attcttcaag cgcgcgtccg tagccttcag 2174461 ggtcacggcg gtgtccgaat aacgcgtcaa aatcaacaag gttcgcaaag ctcagacccg 2174521 taaaatcttc tcccagcgta tcgatcacct tgtccattcc gtccatatta gaaaccgttc 2174581 tgcgtgaaga agtaatgcct tctccgtcgt aaatatcaga gattttaccg attgaaatca 2174641 catctaagcc gcagtctttc aattcattca tgacagtgcg gtcaaacggc ttcagcgcat 2174701 aatcatggcg gtttggcgtc cgtttgaatt gacccggctc tccgacgaac ggccgtgcaa 2174761 taatgcggcc aaccatatat ttcggatcaa gcgtcagctc tctcgccgtt tcgcaaatgc 2174821 gatacagctc ctcaagcggc acaacctctt cgtgagcggc aatttgcaga acagagtcag 2174881 cagacgtgta aacaattaaa gcccctgtct ccatgtgctc ctggccaagc tcatccaaaa 2174941 tcgctgtgcc ggaagccggc ttgtttccaa taattttgcg gccagatctc ttttccagct 2175001 cttgaagcaa ttcatcagga aagccttccg ggaacacttt aaacggttta tcaatgtata 2175061 aacccataat ctcccaatgg ccggtcatcg tatctttgcc gtttgacgct tcttgcattt 2175121 ttccataata ggcaagcgga tgttctgttt tttctacacc tttgatatct tcgataagac 2175181 caaggccgag ctttgccata ttcggcatat gtaatccgtt catatgctcg gcaatatgac 2175241 cgagcgtatg agcgccttcg tcattaaagt cagcggcatc cggcgcttcg ccgattccga 2175301 ctgagtccat cacaattaaa aacacacgat tatatttgta tgcaggcatc ttgaaagcct 2175361 cctttttttc tatacgtcta ttgtatcgct aagaggtctg acaactcaag tataaaccgt 2175421 tttcattccc gttgacaatg tatttggaaa taatgagaaa cttcaatatt ttctgtcgct 2175481 ctaaacaaaa aagccgcagc cacctgcggc tatgctcgcg gatgaaactg cttgtacaca 2175541 tccttcagcc ttgttttcgt cacatgcgta taaatttgcg tcgtggatat atccgcatga 2175601 ccgagcattt cctgcaccgc tcttaaatct gccccgttct caagcagatg cgtcgcaaag 2175661 gaatgcctga gtgtatgcgg agtcagctct ttcttaatgc cggcttccaa tgcgattttt 2175721 ttcaggttct tccaaaatcc ctggcggctg atctgtttgc cgtgatgatt taaaaagagg 2175781 gcgtcagata cattattttt taacagtttt cccctggctt ttgtcatata ttcctcaatg 2175841 gcggaagcag cggcttcacc gattggcaca atccgttctt ttcttccttt gccgaagcat 2175901 cggataaacc ccatagataa atgaacatca gccgttttca attcaatcat ttcactgact 2175961 cgtatgcctg tcgcataaag cagctccagc attgctttat cccgatatcc gaaagggctc 2176021 gtcagcttag gcgtgtccaa taaccgctcg acttcattga gcgcgagcac cttcggaagc 2176081 gcccgttccg tcttttgtgt ttcgatatga acggaagggt ccttatccgt tactttttcc 2176141 ctgagcagaa attgatgaaa agagcgaatg gatgccaaat gccgcgccga tgtcttgccg 2176201 gatttccccg agtccttcaa atgctttaag tattggataa tatgtatgcg ggtaacgtga 2176261 ttccaatctg taacatgaag ggtttctgtt aagtagagag aatagctttt caagtcacgt 2176321 tcataggata cgatcgtatt ttgagagagc cctctctcta ccataacgta gtggatgaaa 2176381 tcctttattt gatctttcac tcttgatcta ctccccgttt tggtaaaaaa agatcaaccg 2176441 gtcgaaccat ccgccttttt catcctgatc catttcaaca acttttacag cggagccttc 2176501 cggtttatca taccgatgat agttttcata ctcttgattc acccatatca tagcataata 2176561 gaacaaagcg gtaaaaccgg taaacaggat gaaaactttc aatgcatcga cagctgtttt 2176621 caggaatctt cccatgtcct aatcgatcct ttccctatgg ttccagttat ataaaccata 2176681 tgccaaatca gaaaggtttt atacatagaa acagcaaaaa accctttccc catgagaaaa 2176741 ggttcgcgct cggcaccgtc tattcagttt cttttccgtt acagcggtgg caaatgccgt 2176801 gaaacgtcaa tctatgatct ttaatcttaa atttccaatc acgttcaatg atttcttcca 2176861 cgtcttcaag caaatcttct tcaatttcat caacggctcc gcactccatg cacaccaagt 2176921 ggtgatgaaa gtgagctgcg ccctctttcc gaaggtcgta acgggacaca ccgtctccaa 2176981 agttaatttt atctacgact tttaattcag ttaataattc aagcgtacgg tatactgtag 2177041 cgagaccgat ctcaggagat ttctctttta cgaggaggta tacatcttct gcgcttaaat 2177101 ggtcttcttc gttttcaagc agcactctta ctgtcgcttc acgctgtggc gtaagtttat 2177161 agctggatga gtgcagttgt ttcttaatac gatcaatacg gttttccatg tctttccctc 2177221 ctacgccgca ttccatgact cattataaca aaatacgcgc agagttccaa ctataattat 2177281 tataaactga taaataaaat ggttttcttt taataatgat tttaaaaaag tctagatgta 2177341 agcttttcca ttaaaacagg agataagtat gcttcaaaga gagatgaaat cagcgctaaa 2177401 aacagaatga ccagcagcac aaaggcatac cgcccgaacc attgaatcgg cgcgtcatgc 2177461 aggcttcgtt tcacgaacag ctgtctgatt aactttaaag aaaacgcaat tgcacatgtg 2177521 cccataatga gataagccgg aatcagcagc acattttgcg gcaaaacgga gacaaatgat 2177581 aggaaaaacc cgcttactcc catctgattg actaggaacc cgacagtaaa gccgacgacg 2177641 atccctttca gaaagatcat aatgaaaata atcggcatcc caatgacgga aattcccagt 2177701 atccacatca ggcctaaata ctttgcatta tgaaagatac tttgcccaaa catatcagct 2177761 gaacttgcct gttttccatc cgaaagctgt ccaaaaaatt gacttaagta gtagtataaa 2177821 tcttctttct ggctgatggt catactgttg acaataatcg cgccaaagat gacacccatg 2177881 aaaaacagca ctgacacaaa tatataaaga gagagatgat ctttgacatg cctgagaaac 2177941 atgtccttat aagagatttt tcgcataccg tttcctcccg cccgctctag tgatttgatt 2178001 taatagattg tatgaaagaa acagaaaaac atgccctttt tcaaaaagaa acaatagaga 2178061 tgaatgctag gcggcttttt ggggcacaaa aaaatcctta tcatcaactg ctgtatgatc 2178121 ataaggattc ttatgcttcc gtttattcaa aatctctttt ttgctttttg tcattcttcc 2178181 atgtgtgctg aaagatggtg tgctgcctct tgataataag acgtcacgtc cgccgtttct 2178241 caatcgatgc ccccgcttct ttttcgcttg gctttttgcc atgtgatcac tccctttttt 2178301 attttcatag taatgataac aaaattgaac aatgataaga aaaaaacagc acctgctacg 2178361 acaggtgctg tttagctaca tttatttcac tgctgtaaga gctgcatgct cgacagctgc 2178421 tgctaccgca tgatggactt ttgaatcaag cggctgaggg acaacatcac cttgtttagt 2178481 gcaagctgcg atggcctctg ctgctgcgac aagcatatca tgattaatct ccgtgctttt 2178541 tgcgttaagc gctcctctaa aaatccctgg aaaaccgagt acattattaa cagaacgccc 2178601 gtcagctgca tatgcggcgc cagcctgcag tgcggcctcc ggctcaattt ccggcttcgg 2178661 attcgataaa gccagaatca cttgaccaga acgtacaaat gccggtttta ttaaacccgg 2178721 aacgcccgtt gtagcaatga caatatcaca tgtttccata agctcctcaa tactggaaac 2178781 tgcctgtccg ccgtattgtt cgagacggtt cattgctgac tctgatttgt ctgttccgta 2178841 tacagcattc acaccataag ccatgaacat ccggcagatg gccacgcctg ctgcgccaag 2178901 gccgatttgc cccactttcg cttccttcag gtcaaccccc gcactcctgc atgccgaaat 2178961 ggcagctgcc agcgtcacta cagctgtacc atgctggtca tcgtgcataa cagggatgtt 2179021 cagctcctct tttaggcgat cctcgatttc aaaacaatgc ggcgaaccga tatcctcaag 2179081 aaggatgccg ctaaagcccg gagaaatatg ttttactgtt ttgatgattt cttcaggatc 2179141 actcgtatca agcagtatcg gaatgccgct aatacccgcc agctgatcaa ataaagcagc 2179201 ctttccttcc atgacaggca tgccagccac agagccgata ttcccaaggc ctaaaattgc 2179261 ggttccatcc gttacaattg caacagaatt gctgatcgtt gtataaatag aagctttttc 2179321 aggttctttt tcgatcagtc ggcacacgtc cgcaacacct ggtgtgtaga cacgtcccag 2179381 ctctgccagt gaacggatcg gcattttgct tttcatttgg atttttccgc cttcatgtgc 2179441 ggacaggact tcatcagata cggtgtgaag cctgatccct tctccgaggg cctgtacagc 2179501 cgcgatcact tcctgaagct gttcttcatt ctccacttga acggtaatat tccgcattgt 2179561 gtaattgggt ccgactttta ccgtctccac ttcaccaata tccccgccca gaaggccgat 2179621 ggccgtagcc acccttccaa gatttccggg aaccgaaggc gtttcgatca tcagtgtccg 2179681 aatcatgtgt ttcgctatca ttcagtgatc ctcccctatt agcctagttt ttcggcttta 2179741 actgtattgt ttttcgtata ccatataaat tttcctgtat aaccatagat aattgcaaga 2179801 cctattgcta caaaactgag ccacataaac ggcagataag agaaggtaga aacacctaaa 2179861 ataccagcca tgtaaatccc attatcagac caaggaacca tccccgaagt caatgttccc 2179921 ccgacctctg agttacgtga taacactctt ctgtccagat gtaagcgatc atagctgtct 2179981 tccataattt tcggagtcaa aataagagat acatacatcg cacagccgaa gatgtttgct 2180041 aaaaacgcta cgatcagtgt agacaatgtg acattgccgg ctgaagttaa tttcttttca 2180101 aacgttgaaa caatgacttt taacacgccg agtttctcaa gcagaccgcc aaaaccaagg 2180161 ccaaagatga tgacgacgag agaatcaagc ataccgacaa ttccaccgcg gtttaacaag 2180221 ccgttcaaaa attcaacatc cgttttaata gagaagccgt tgtacgcagt tgcaatcgca 2180281 tgggcaatat ccattccttg gaaaacaaca gcccagattg caccgagtaa agcgccaatt 2180341 acgataactg gcatagatgg ctttttcatc gccaataaga ctatgacgag aactgccggg 2180401 atcagcatcc aaatatgaat gtcaaacgtg ttttgcaaag atgattttaa gaattcaact 2180461 ttatcaagat caatattttt cccgccgtac ataaatccaa caactgtaaa gagtatagct 2180521 gtaatgacat aagcaggtat tgataaataa agcattgctc tcacgtgagc caatacatcg 2180581 acttttgata gtgaagaagc tagaactgta ctgtcagaca gcggagacag cttgtcccca 2180641 aaataagcac ctgaaagaat agctcccgct actagaggaa gcggaatgcc taacccctct 2180701 ccaattgcga tcatggcaat gccggcagtt ccgactgttc cccatgacgt tcctgttgcc 2180761 acagacataa tggaacaaat aattaacgtt gccagtaaaa agatacttgg gtgaataaat 2180821 tccagtccgt aataaatcaa agtcggcaca acgcctccgg caatccatgt tccgatgagc 2180881 gccccaactg aaacgagaat cagtacggct tcaaggccat ttgatatccc atgtacaatc 2180941 gcattttgta aatctttata agaataaccg agtctaatac ctaaaagcat tgcaataaac 2181001 catgaaacaa aaagcgccag ctgtatcggc aagtcgagaa agactgtaaa cgatagaaca 2181061 agtgctaaaa atactcctag tacaataata atttcaaata gtgttggcaa tcttacatcc 2181121 ttcaaaagaa gtcccccttc atgtaaaagc taaaacgctt tcaatatata gtgcaacacg 2181181 tatactatac ttcctcatcc ctatgttgta aacagcttat tcatccgact attcggagat 2181241 gaataagctg tattttatac aaattttatt tttctaatag ttctttccct gcgatacctg 2181301 gtttggtcat ctcatatggg tttaaaataa tatccaattc ttcttcagtc agcacatcat 2181361 gctgcagaca aagatcccgg acagattgcc ctgtcataat tgcttccctg gcaattctag 2181421 ctgccgcttc atacccaaga tgcggattga cagctgtgat cacgcctgcg cttttttcta 2181481 cgtattgctt catacgcttt tcgttggctt caatgccttt taagcagttg tcagtgaacg 2181541 aacggaagcc gttgttcatg atgctgatgg attgaagcaa attaaagaca agcacgggct 2181601 ccatgacgtt caactcaagc tggccggctt ctgaagcaag gcagattgta ttgtcatttc 2181661 cgataacctg gaacgcaatt tggttgatca gctccgccat aaccggattg actttccccg 2181721 gcataataga tgaacccggc tgacgtgcag gcagagaaat ttccgcaagt ccggcgcgcg 2181781 gtcccgacgc cattaagcgc aggtcgtttg cgatcttcga catgttcatc atgcagactt 2181841 ttaatgaagc tgatacctct gtataggcat ctgtattttg tgtcgcatca acaagatgat 2181901 cagcgccgac aagaggaagc ccgctaatat cagcaaggtg ctttactacc tgtttgatat 2181961 attcaggatc agcgttcagc cctgtaccaa cagcagttgc gcccatgttg acttcataca 2182021 ggtgctggcg cgattgcttg attcgtttga tatcacgctc gagaacacgg ctgtaagctt 2182081 cgaattcctg gccaagacgg atcggaaccg catcttgaag gtgtgtccgg cccattttaa 2182141 taacagagtc aaactcctgt gctttttgct taaacacact atgcatatct tccattgttt 2182201 tcagcagttt ttctaagagc ttcaatgtgg aaatatggat agcagtcggg aacacatcgt 2182261 tcgtagactg tgacatgttc acatgtgtgt ttggacttaa atggatataa tctccctttt 2182321 tatgtcccat gatttcaagc gcccggtttc cgataacctc attcgcgttc atgttcatag 2182381 aagttccggc accgccctga atcggatcga cgataaactg atcgtgccac ttgccttcca 2182441 gaatctcgtc agcggcttgt acgatagctt ggccaattcc ttcatacagc cgtttcacgt 2182501 ccatgttggc aagagccgca gcttttttca caatcgccag tgcgttaatc atttcctcat 2182561 ggattttgta tcctgtgatc ggaaaatttt cagaagcacg gagcgtctga attccgtaat 2182621 aaacatctgc ttcaatttgt ttttccccaa ggaagtcttt ttccacgcga tattcttttt 2182681 ggccgtttaa cataatcttt aaccttcttt ctctttgctg gttatcgttt ttacatttta 2182741 caggacaacg tcatcagcta tcggcgtttc cataattctc ttgacgacag gaagatccga 2182801 agactgacct agcgcccaca tcaattttgg cacaattgct tctgtgttca tatttcttga 2182861 tcggataatt aagtcttggt tgactctgcg gccaacctcg taaatgctca tgtcttcgcc 2182921 ttcttcaaga cattgagtcg taatgacgac gacaatgccg ctttcgatca gttcattcac 2182981 ttttgacaaa atgtctctgc cttcaaacgg cactcctccg ctgccataac tctcaatgac 2183041 aattcctttg tacatgcttt tcagggcatc aaacatttcg ggctttaagc ctggatgcag 2183101 cttcagcaga catacatctg tgcatagtga agtgtcaact gtgaaggtgt cgttctcagg 2183161 ttccgttact tgtttgttgt attcgatccc gtcttcattg ataaaagcga tatatgggta 2183221 attgatgctt tcaaatgcgt cgtagctttt cgttcttaat ttgatcgcac gcgttccctg 2183281 aatgactctg ccgtcaaaca caacataaac gccgcccacg ccttcacagg caaatcgaat 2183341 ggcatctgta atattttttt tggcatcggt tttttggaac gtgatcggaa tctgcgagcc 2183401 ggtgatgaca atcggctttt tggcatgctg cagcatatac gatagtgcgg cagatgtata 2183461 ggccattgta tctgtaccgt gagtaataac aaacccgtca taggcatcat aattttcctt 2183521 aacggcttct gctatttcca cccagtattc aggctgcata ttggtgctgt ctatattcat 2183581 aagcgactga gtttccattg tgtaatcgtt atcaagtttt gatacgtaac ttaataattc 2183641 atcagccttg actccgggag ccagcccatt ttccccttca actgaagcaa tcgttccccc 2183701 agttgtcaac atcaataatt ttttcatacc atgcacctct tcactgtatc taaagatggg 2183761 ttgcgagaag gtattcgctt ttcgcatact tttaatgcaa ttatagacac ggaaaataaa 2183821 atacgcaaga cattattatt caattcgcgt acacttccta atacctatat gatataatca 2183881 gctcaaggtg aaaaaggagc ggaagttcat gaatctagat cgtttaactg aattgagaaa 2183941 aaagaaaaat tggtcgcttc aatatacagc tgaccttctc ggtatcgcaa aaagcacata 2184001 tgccggctac gagtcaggct accgacggcc ttcacttgaa gcgcttgcca tgctggctga 2184061 cctctttgac acaacctgcg atgaactttt aggccgcgag aaacaaaagc agactgctcc 2184121 tcaggccata gaattggcca cgtggagcag cctcgacttt accatttctg ttgatggcca 2184181 gccgctgagt gaagatgaaa tcatccagct gattaccttt atacgcacaa aaagaaaagt 2184241 acaggaggaa ctgagttaat ctttagctca cggtttaatt ttaccgtagg ttcctcctcc 2184301 tccggctttc aattccagtt ttccggatct cgcttttacg ataagcgccg cggttttcgg 2184361 cgggacaacg cgagccaaat cttcttctgc agcctcatga agaacagcca tttctgttcc 2184421 gaaggctttt tttagtttgt ccagcgtttt cgggcctaca cccggaacaa attgcagcgg 2184481 gatctgatgt acatatcgcg gacgcgggac gcgaacttca agctgatcac tcaattcacg 2184541 caatctatcg ctgactccct tggtaaatct ggcttttccg caattcgcgc acgctgtttc 2184601 cccgcttaca gcaggctctc cgcacgcttc gcaagccgtc tgataatatt tccccaataa 2184661 cgggtccaag ccataatttg cgataatttt cctgtcatct tgtcccttta atgcaagagc 2184721 aaattcagta aaatcagctg actgcacata taattcatta tattctctgc cgattttccc 2184781 caacgaatgc gcatcagaat ttgttaaaaa aggatacgga ttcaattgcg atacgtgtga 2184841 tgccatgtct gtatcacagc ttaatccaag ctccaccgcg tctatcatag atggatcaaa 2184901 aacctcagtt aagcttgatt taaccccttt tccatataag cttttatgcg gcgtaaagat 2184961 atgggcgggg ataaacaggc cgcccatatc ctgcactttt ttttgcaggt ttaagcccgt 2185021 ttcataaatc cgctgcgagc ttaaatgaat atttttcagc cgggctgaca gccagtttga 2185081 aaactgtttc atatcagcca gcgtcggcat aaatacgagc acatggatcg gtccgctgca 2185141 ggcttcatca taaatctcca gctcgctccc caataaaaga gtcgtgctgc gataacggat 2185201 tcctcccccg tcaagctcgc gatattttcc agatgaaatg ccttcctcaa gctctagaat 2185261 gacttccgga gaatgacagt cgataatgcc gaggagttca attcctttat gttcactggc 2185321 ttcaaccaaa attctgtcca gcgttaatgt tttggcgcct gttattttga cagcccttcc 2185381 tgtaaaggtc cggccgatat gaatgtgcaa atccgcgtaa atctttttca tttttgtgct 2185441 tggagcgctt ctttcagctg aagatactga atcgcgtagg ctgttttagc atcatatact 2185501 tcacgcgatt caaccagctt tagcgcatct tcaagcgtca cctccatcac ttcaacaaac 2185561 tcgtcctcat caagctcccg tttttcttca agcacagaaa gctcctcagc aagaaaaacg 2185621 tgaacgattt catctgcaaa tccgggtgat gtataaaacg cagttatttt tgtcagtttt 2185681 tttgctgtat aaccggtttc ctcttcaagt tcccgaagtg ccgtatactc cggctcctca 2185741 cctttttcaa gcttaccggc cggaatttca acgatcgtcc gctcaagcgg cttacggaat 2185801 tgtttgacca tgatgatttt cccttcatct gtgacggcta gtaccgctac agctccaggg 2185861 tgtttcacaa tttcacgttt actggctttg ccgtttggca gctctacatc ctcgacataa 2185921 agatcaatga ctttacccga aaaaatctgt tctttggcaa ttgttttttc ttctaatgat 2185981 ttcatttctt catctcccgt tctgtctcta tatgatgccc catacatttt atcatactag 2186041 agcaaaaggg ggcttcttcg tgaaagtgca ccgcatgcca aaaggtgttg tcttagtcgg 2186101 aaaagcatgg gaaattcgag cgaagttaaa agagtatgga cgcacatttc aatatgtgaa 2186161 agattggatc tcaaagccat aaaagttgaa actttagctc ctttatatta cggtcaatac 2186221 aaagcctaaa aaaggagtgt gcacatgaga aagcgcaaat tgggtacatc tgatttagac 2186281 attagcgaag tcggactcgg ctgtatgtct cttggaactg aaaaaaacaa agcattgtcc 2186341 attctggatg aagcgatcga gcttggcatc aactatttgg acacagcgga tttgtatgac 2186401 cggggacgca atgaagaaat tgtcggtgat gcgatccaaa acagacgcca tgatattatt 2186461 ctggcaacaa aagcgggaaa ccgttgggat gacggaagcg agggctggta ttgggaccct 2186521 tcaaaagctt acataaaaga ggcggtaaaa aagagcctta cacgtctgaa aacagattat 2186581 atcgaccttt atcagctcca cggcggcacg atagaggaca acattgatga aacgattgaa 2186641 gcgtttgagg aattaaaaca agaaggtgtc atccgctact acggcatttc ttccatccgc 2186701 ccgaatgtga ttaaagaata tgtaaaaaaa tcaaacatcg tcagcattat gatgcaattc 2186761 agcctgtttg acagacgccc tgaggaatgg ctcccgcttt tagaggaaca tcaaatcagc 2186821 gtagtcgcca gaggtcctgt tgccaaaggg ctcttaactg aaaaaccgct tgatcaagct 2186881 tcagaaagta tgaaacaaaa cgggtacttg tcctattcat tcgaggaact gacaaatgcc 2186941 cgtaaggcaa tggaggaagt ggctcccgat ctttccatga cagaaaagtc gctgcagtat 2187001 ctgctagcac agccggctgt cgcttcagtg attacaggcg ccagtaagat tgagcagtta 2187061 cgggaaaata ttcaggcagc aaatgcacgg cgtttaaccg aagaggaaat caaagcgctc 2187121 caatctcata cgaaacaaga catttacaaa gctcatcgct catagcagaa aaaccagcac 2187181 ctgtacgggt gctggtttat ttatattgat gccaatccat ttggctttca tttaggagtt 2187241 cttcaaagct cttatttttt tcgatctctt ttttctttct aatctgttct gctttttctc 2187301 ttttctgcct cttttcatcc tcttccttca attggctctt catctccata agctttgctt 2187361 tgatatcgga ttgaaggccg tcttttagct ggtgtttgtc aatggatttt tgttttttca 2187421 tgcagacttc ccccatgttt tgttttgaag ccagtttatc acggagcata taaactgaac 2187481 aagcagactc tcttctgatc actttctcag cgtagcagtg tttaggtata atgatcttaa 2187541 acacgaattg cctatatatt tcgttgaaag gtgctgtgac ttttgaagaa aatccttttg 2187601 gccattggcg cgctcgtaac agctgtcatc gcaatcggaa ttgttttttc acatatgatt 2187661 ctattcatca agaaaaaaac ggatgaagac attatcaaaa gagagacaga caacggacat 2187721 gatgtgtttg aatcatttga acaaatggag aaaaccgctt ttgtgatacc ctccgcttac 2187781 gggtacgaca taaaaggata ccatgtcgca ccgcatgaca caccaaatac catcatcatc 2187841 tgccacgggg tgacgatgaa tgtactgaat tctcttaagt atatgcattt atttctagat 2187901 ctcggctgga atgtgctcat ttatgaccat cgccggcatg gccaaagcgg cggaaagacg 2187961 accagctacg ggttttacga aaaggatgat ctcaataagg ttgtcagctt gctcaaaaac 2188021 aaaacaaatc atcgcggatt gatcggaatt catggtgagt cgatgggggc cgtgaccgcc 2188081 ctgctttatg ctggtgcaca ctgcagcgat ggcgctgatt tttatattgc cgattgtccg 2188141 ttcgcatgtt ttgatgaaca gcttgcctat cggctgagag cggaatacag gctcccgtct 2188201 tggcccctgc ttcctatcgc cgacttcttt ttgaagctga ggggaggcta tcgcgcacgt 2188261 gaagtatctc cgcttgctgt cattgataaa attgaaaagc cggtcctctt tattcacagt 2188321 aaggatgatg actacattcc tgtttcttca accgagcggc tttatgaaaa gaaacgcggt 2188381 ccgaaagcgc tgtacattgc cgagaacggt gaacacgcca tgtcatatac caaaaatcgg 2188441 catacgtacc gaaaaacagt gcaggagttt ttagacaaca tgaatgattc aacagaataa 2188501 aaaagcgaaa ggcctcttcg gctctttcgc ttttttatgt tacagaacgt cggtaatgcc 2188561 atccatattt tctctgatcc attcaatcgc aagatctatc gttgtaaact cctgcgtctc 2188621 gaaggtcatt tcatcctgca atagccagac atctttcttg atggactctg ctcctccgat 2188681 tgaccagtga agcaaggtat aaggatggtt ttgattcagg aaggataccc acgttttatt 2188741 ttgtgctgtg ttcttcattg ccttcagctt ttgttccacg tttcgcgtct cctactttac 2188801 taatatgctc attctggggc tgagcatttc agccgggctt ttcagcgcca atgttttggc 2188861 tttttcattg taatcgatcg tcatttgatc gtcaaaaaac actttttgcg acgattggat 2188921 atacagcgga atgccgttcg tttccagctg ctcgcactgt cccgttaatt cttctgccag 2188981 ccagattgtc gggacaccgc ttaccgcgca gccgcatcct tctgcatcgt aacgaagctg 2189041 ggcttttttt cccgggttgg cgtcaaacgc ctgctgcagt gcctgttttg ctgcatctgt 2189101 cacatgtatg ttcataaggt gaaacccccg ttttcatcat tttcgctatt gtagcataca 2189161 atactgccat tcgcattgtt tctgcctttt ttccaccgct tcgcattttc ttctgcagtc 2189221 ttgatccact catctttccc ttgtatatac tgattgatgc tgtcagggtg ctgggccgcc 2189281 agctgttttt tgagaacggc gtattctttc gctatgtttg gatgagctct gagataatct 2189341 ctgaataaca gatgcctttc aatagcaggg tttccctgtt cgtacatatg gacatgatga 2189401 gtgcgtttat ttccgccctt ttggaaataa cgcctgcccg ctataccgtt ctcacctttt 2189461 ggtgtatagc cgttggcctt catttgttca tcaaattggc tcacggcttc aatgcttctg 2189521 acttcaatta acatatcaat gattggcttc gctgccatgt taggtattga tgtgcttccg 2189581 atgtgatgaa tagcgataat ctccggcccg aacacaagtt tcagccgttc tttttcttca 2189641 tcgaaacatt ctgcccattt ttcgttgtag agaatgatct caacttttct tttcggatac 2189701 aaatgaaaga ccgacagcaa tagaccctgc gctgctttga cggtttctgc cttttggaat 2189761 ccggcctgtg tatagagtga cacagccggg gtattgttct cggctgtgac tacttcgatt 2189821 ttctcagcgt cttcattatg atcaatgaca aattgcagaa gcgctcgtcc aattcctttt 2189881 ctgaaaccgt caggatgcac aacaagcctg caaatggtga gataatgcat gtttttctca 2189941 tatgaaatga caccgatcag cttgccgttt ttccgatatc ccgcaaaccg ttcatgggat 2190001 gcttgaatat cctttacctt ctcttgtaaa gcgggaatac cgtcaaaacc gataatctct 2190061 gtttccttta tgtaggcggg gatctgtacg gctaaaatct cacgcgctat agtggcttcc 2190121 ttatgctgga gaaattcaat cattcgtgtt ctcctgaaac agccgctgtc tgtcgacttt 2190181 tgcgacgcgg actgcatacg actcgtacca aacgcttctt cctttttctt ttgctgcttg 2190241 atgttcagtg tgatgcctcc aatggttaat tgcgtccata ctgtcccaat aggaaactgt 2190301 gatgcccctt ccatccgctt cacgtacgct ttccacgcct aaaaatccag gctgatccgc 2190361 cgcaagtgat accatccgct ccgctgtttc tccatatcct gtgtcatttt cgcttttgac 2190421 agaagaaaaa atgactgcat agtaaggagg ctcaggtgtt tttgataaaa aatccatcat 2190481 atttccccct catatgtttt tgacaaatag taccctgtct tggcccgggc catcatagtt 2190541 tgcaaacact gagatgccat ttaccgtttt ggtgcccttt tcaatatcaa accccaattt 2190601 tgtgtgatat gcgattgata ccttattcac aggtgaagtg acacacttca cccgggtgca 2190661 gcccctttgt tttactgttt cgataaatac atcatacaat tgtttcccaa tttgcatttt 2190721 tctgaaatcc ggatgcacac cggaaaaatg aatgtacgcc gtttcaggat cggattgcga 2190781 ttgaaatccg attaaaaatc ccgtcatgct gttatgttcg gatgtaataa agcttgtgtc 2190841 ctgaaaatgc tcaaaaaata gtctcggcaa tttttctttc agctgtctgc cgccccacca 2190901 ttcattcagt acagacgtta ccatttcata atctgaagac gtgattgttc gaatatccat 2190961 tacgatttga tctccctccg tctggcaaaa cgaatgtcag ctctttttct cacaatataa 2191021 aaattatatt ttgcctggct ggaattgtaa atgccttctt tcctgtatca tacgtttcca 2191081 gactgccgag ggaacaatgt ttgatcattt tacgcctatt tctcccccaa acaggaggag 2191141 agactttaca gcacaatatc aagcacttga tcaagtttca gcttataaag ctgatcctcg 2191201 tctcctttta tccatactgc tttttcaaac tcttcatacc ggcagatttt cccggtgcag 2191261 cagacaatct caccgtcctg aaagcagctg acagtgatat cctgagcaaa ctccatcgcg 2191321 gcgcaaagcg tttgattcat ctcttccagc ttatcggggt caaggatcgg cttttgcagc 2191381 ttctgtttaa gtcgctttct ctccagcagg ctttgcttat gttccggcag aaacatcctg 2191441 ctcccttccc acagcaggtt gccccttttt aaatggtcgt tcatttataa tgccccccta 2191501 ttttagccgc acgttcaaat gcctggcctg ccgctgtcag tgacgccgcc ctgatgattg 2191561 ctgtatcgcc gaatcgattt ttaatgccat ccatcacata gcctaggctc attttctttg 2191621 cataatcctg aaataaattg agctgccata tgtcatcaga tgagagctga gacagattga 2191681 caccgaggcg gcggacgggt ttcccgtccc aaaatgtaag aaacagccgt cgtacagcct 2191741 catatacatc ctgcgtagaa ttagtcggct ctgccagctt cacttgccgg ttgaagcccg 2191801 tcggccaatc aaaatcagca ccccggcagc tcactgacac tgtctgcccc atgaccccgg 2191861 cgtttcggct tcgcctgcac acctcttcac tcagctcaag caatacgacc ttgatttctt 2191921 tgtcaaagtg ttcgtagtct ctcgggagag tcattccatg acctatcgcc ttttgcccgt 2191981 ccagagacga agttgacaca ggggaatagt cgattccgtt tgccgtcatc cacagcacgt 2192041 ggccgttaat gccccatttc ttttttaaaa gatcgagcgg aaaagccgcg agcccgccga 2192101 tcgtgctgat gcccattcga tttaaatgat gcttcatgcg gctcccgacg ccaaacatgc 2192161 tgcccaccgg gagcggccac atttcggttt tcatattttc tttcgttaag gtaaaaatac 2192221 cgttcttatt ctttttggca aaattgtcac acgcaatttt ggccagcgct ttgttagggc 2192281 cgattccgac ccgtgcataa acgccgatct cccgcatgat tctgccctga atgcttttcg 2192341 cgatctccat cggcgtccca aacagcttct ggctgcctgt aatgtccatg aactgttcat 2192401 cgatggaata cggctccaca aggtctgtat actcctcgag aatggccgta atttgcagtg 2192461 atacatcaat ataccgctgc atacgcggcc ggagcacaac agcctcagga cacttttcct 2192521 gcgcctccca cagccgtgaa gcattcacca cacccttttg tttcgccagc gggcaggcag 2192581 ccaatacgac tccgcccctt ttttcagggt cacccgaaac aatgacgggc ctatttttca 2192641 aatgtggatt ttccgctttc tctacagatg cataaaacga ttgcatgtca acgagaaaaa 2192701 tcactttttc tttcatcata cacacctcta aaaagaactt atgttcgctt ttcattatat 2192761 gcgaaagtat gttcgtttta tactggtaaa tgattcttgt ctgacagaaa atatgatcca 2192821 agggtttgag agaagaaaaa catttagtag aataaaagcg aagcataagg ataggagagt 2192881 catgatggag aaatttgtcg aaaaaatgct gggacaggca ttgcggcaat acggcagaaa 2192941 cgttgctata gatccgttaa gcccgtatga aaaacaaagc ctgaaagcgg ctctacaaga 2193001 gagacggaat gaagaaccag atgaggattt gcatgcgcat atagaagata tcatttatga 2193061 ctatgtcaca aaccaaggcc tgttctctta aacgcatgac tgtcagttct ttcagccgct 2193121 gatgcggctt ccctttgaaa acaccgcctg aaacaaataa acagtctcag gcttacagaa 2193181 aaaaagcagg attttctcac gctccataga ttcatatggc ctggcgtaaa attcccctca 2193241 atgctcgcgc aaaacggaat aagctgtcca tgatcacgcg tatacacttt ttcgaagaga 2193301 tgtgctctct tgttctgtca tgcggtccat gccggttttc agcgtacatc ttgatctcat 2193361 agccggtttc actgccgata tgatccacgt tctggcggct taaactaaca caccctcact 2193421 gaccaatcgc tttgcttttc atcggacatc ccgtcatttt ccttctttca agatgtaaac 2193481 tccgtcagcc acacgcatcc tcaacgcata gtatattgcc atccatacaa tcaggcatac 2193541 tacatgtcaa taacgaaata ttttgaacga tctattggag aaggaaattt tttcatatat 2193601 gatagagaaa gatcatacat acaggagaga atataattca tgaagaaatg gaaagatatc 2193661 cacccgatca gctggacaat tataatcgga accattttcg gcagaatggc aacatcgatg 2193721 agcattcctt ttttagcgat ttatttgaca gccgtccaag gcgcatcagc ttcctatgca 2193781 gggctggtca tcgccgcgag ctcatcagtc ggcatcctcg caagctttta cggcggatat 2193841 atctcagata aattcggcag aaaaaacatg atgcttgtat cgattttcgg atggatgctg 2193901 gtatttgcag gctttgcggc agcatctaat ctctgggtgt tttttgtagt aaacgcatta 2193961 aacggtcttt gcaaatcact gtttgagccc gcttcaaagg ccttgttgtc tgatatgaca 2194021 gaagaaaaaa cgagactgct agtttttaat ttacgctatg cggctattaa tatcggcgtt 2194081 gtcttcggac ctgtgcttgg cctatatttc ggctcatcgc aatcgactac gccctttttg 2194141 gtgcctgcag tcatttacgg actatacgga attgtgcttg ccctccaatt taaaaaacat 2194201 ccatccttat cagcaccagc ccagtcccga aatatgagcg tgcgggaagc gtttatggtc 2194261 acgcaaaagg attatctttt taccattgct ttggtcggca ttacgctatg caccttcggc 2194321 tactcacaat tcagttccac attccctcag tatatggcgc agaacccctt gatcggcaat 2194381 ggaacgaagc tgtatgggct gatgctgaca ttaaacgcaa tcgttgtgtt ggcgacgcaa 2194441 tttcccattg tccattttgc aaaacggttt tcgccgcttt gttctctgat gctcggtaat 2194501 gtgatggtta gcatcagcat ggccattttc accgtatcac acggtgttcc atcaattgtg 2194561 atgattgtca tcacatttac aatcggcgaa gtgcttttat tctctatgat ggatttgtat 2194621 gtagaccaga ttgcaaaacc aggattaaaa ggcacttatt tcggggcaat cggtttttca 2194681 cagctcggaa acgtcatcgg cccttgggtc ggggggatat gtatagacct gtttggcgct 2194741 ggccggccga tttatatttt ttctgtcctg agcggcatta ccctgctcgg cctgccattt 2194801 ttagcgttcg cctatcggca aatgaaaatg gagaccacaa aacaccgttc ccgtctggaa 2194861 aagccgcttt aaataaaaaa cggaagagaa tgaatctctc ccgcaaacat gaggtgaaga 2194921 acatgaatat aggtgatgtg atgtttcagc tgtttgtatt tattatattt gccgctgtcg 2194981 tctttgcggc tgttacaggc ttcaagtatg cgaaaaaccg aaaagcgcag ctggatcgca 2195041 ttgagaaaaa gctgaacagc ctgtccgaag atcacgatta acagcttggg gcaacgagct 2195101 ctaccttaat ccggtctgga tcctcacaaa agactgcata atgcccgtct cctccggcaa 2195161 aaggatgcct gtctcggtac aacacacgat agccttttgc cgtcaatttt tcagtcatct 2195221 gatcgacttg aagcttggat tcagcatgaa atgcgagatg gttcagaccg actcggcatc 2195281 tatggtattc cggctctaga aatggctctt tcgcctgcac aatcactagg taaaaacgat 2195341 ctttcttcca gctgatgcct gagctccatt tttgatactc tttataacca agttctttta 2195401 agaaccagcc ccaaaaccgc ctagacgcct ccaaatcaga gacatacagt tcaatatgat 2195461 gcacatttca taccctcctt accaacactt cctcgacctt atgcccgtct cccttacgca 2195521 aaatgagatc tgacctgaat ttagttggca aaatattttc atataaattc ggccggttga 2195581 cactctccca aatcgaggct gccatctcgt cagcctcctg atcggacaag tctttaaatt 2195641 tatgaaaata tgaatcagga ttttgaaaag ctgtttcccg aagcaggcga aaacgctcta 2195701 aataccaagt gaaaatccgg ctttcctccg catccacata aatcgaaaaa tcaaagaaat 2195761 cggaaacaaa aatacgcggg ttttcccggt catcctccaa ggtgggcgac tgaagaacat 2195821 taatgccttc aataatcaca atatccgcct gttctacaac ctcgaacaca ccttcctcgc 2195881 ggtcataggt tagatgggaa tacaccgggg cctttacgct gtcctttcct gattttaagt 2195941 cattcaaaaa ttcgagcagc gcctttacat catagctttc aggaaatcct tttcttgaca 2196001 tcatattttt ctttttcagc tcggcagtag gaaataaaaa accatctgtc gtgataaggc 2196061 tcacttttgg acggtcaggc aaacgcgaaa gcagcttctg caagatccgc gccgtcgtgc 2196121 tttttccgac tgcgacactg ccggcaatgc cgataataaa cggaattttg gctgaatgtg 2196181 ggtgcttcaa aaaaacattg acatgcttat tgcgttcagc cgcagacttg acatgtaaat 2196241 gaagcaagcg aacaagcgga atatagatcg tctccacttc ttcaacagat agataatcat 2196301 tcaatccttc cacagctttt gcctcttctt cagatacagc aatcgacaaa tgccccccaa 2196361 aaccagacca agactcccga ttgtgctgtg tatataaagt atgtaggtta agttctttat 2196421 ttttcactgt ttacacctga ctctctgtag gttaaaaccc ttacaaagat tgtaacggaa 2196481 aaccttttca ctgtctgctt atttttcatt tcgttttttt agcaaatcag caccgattcg 2196541 gttatacgca gccatttcat cttttggaac catgcttcct cccgttcccc agacgacatg 2196601 tacggcatgt tccatcttat atttctgagc atagcgcctt ccctcttctg tcgaaaaaag 2196661 ctgaaccggc ccgaacatgc cagcaagagc agagggctct aaatatttat cttcagatac 2196721 agccagcata tgaagcaaag tataaagcgt attgtcctct accgtataac agccgctcag 2196781 aagcggttca atcagcttgc cgacaaatcc tgacggcctc cctacggcaa gtccgtcagc 2196841 agccgtctga ttatccaggc cgatatcctg gacggagatc ttctcgtgaa gtcctgaata 2196901 aagccctaac agcatacaag gtgaatgagt tggttctgcg aaaaacacat gaacatcatc 2196961 tccgtataaa agcttcagcc caaatgctac accgcccggt cctccgccga ctccgcacgg 2197021 cagatacaca aacaagggcg tctcaagact tggctttata ttcatacagt caagctgtgt 2197081 ttttaatcgg cttgcagcaa cagcatatcc taagaacagc tgacgagaat gttcatcatc 2197141 aataaaataa cagaatggat cttgttccgc ctgccgtctc ccttcgttca ccgcttcact 2197201 gtaatctgtt tcgtactcca taacagtgac tcccttttgg cggaggagat cctttttcca 2197261 ctgcttagca tcggcggaca tatgcactgt cacgcgaaac ccgagtgccg cgccgatgat 2197321 gccgatgctt aaacctagat ttcctgtcga accgacagca atcgaatagc gggagaaaaa 2197381 cccggtaaac cgctcttcct gtaagatgcg gtaatcatcg gtttcctgaa gcattccttc 2197441 ttgaagcgcg agattttcag catactttaa cacttcataa atcccgcccc tcgctttaat 2197501 cgatcctgaa atcggaagct catggtcgca ctttaaaagc catcttccgg gaaatggctg 2197561 ctgatatgcc gcttccagct ttcccttcat atgctgcacc tcaaaaagcg gagactcgat 2197621 gattccttta gcgcctttcg tctcaggaaa cacctcggca atgtaaggtg caaaccgctg 2197681 cattcttttt tccgcttccg ctatctcggt tgcccactca tctgcacggg gtaatggccc 2197741 ctctttcttg cctgaatttg cccagaatac aggctctgca tcaatcagtt tctgaataaa 2197801 cggatcttta agcagagcat gaaggacttc tgaatgaact gacattcaac aatctctccc 2197861 ttccactatc aaaaactgcc ccgtgagaaa caagccactc caccacaggc agttctatca 2197921 ttattttttc atgagcgcgc gtcctgccag cttttctaca agagctggaa acagctgata 2197981 cagcttagtg ccggcattca ttaaacgcgg aagattgatc tcccgctttt tcgtaaaaat 2198041 tgcagctgta atttgagctg ccacgtcatc aggatcaagc atccagcggc cgacattttt 2198101 ggcgtagtcc ccgcctttat cagcaatgga aaaaaagtcc gtctgaatcg ggcccgggtt 2198161 gactgttgtc acataaatgc cggttcccga aagctccatc cgcaaagcgt ttgagtaacc 2198221 taacacggca tgtttggtcg cggaatacag gctagacttc ggtgtggcga ttttccccgc 2198281 ttgagaggcg atattgatga tatgtccctt tttttgctca agcatttgcg gaagcaccgc 2198341 ttttgtacag gcgatcaggc cgaagacatt cacatcaaac atcgctttca tgtcatccaa 2198401 tgtagagtct aaaaccgttt caaatatacc gaagcctgca ttgttaatca gtacatcaat 2198461 cgagccgatc tgatcgcgga cccgggcgat atcctctagg cggccgacat ccagaggaaa 2198521 aatctcacac tgtccgctcc attcctcggt tattttcctt ttgatttcta tcaaacgatc 2198581 ctcgcgtcta gccgacagca ggacatgggc tccttcagcc gcgcataagt atgcgattct 2198641 ttctccaagc cctcctgaag cgccggttat ccaaatcctt tttcccgcta tatgtttcac 2198701 ccatttcacc tcttcattgt tttaaagtat acggtatttc cttcccaata tgacgtgatg 2198761 gcttcttcag cctccaacac atcaaggtga cctgccgttt ctgacatcgt taaaaacaat 2198821 tccttttcat atacagcagg aaaaagctgc tgacagacct gaaaagcggt catcggcttt 2198881 tcatccagca tgcgacgcac atcctccgtc ctgttcctct gcttgtcaaa acgcttctca 2198941 atcagcgctt gtacactggt gataggctcg ccgtgaccag gaaatacgat tgttggatca 2199001 agttgagaca gccttcgcaa tgaccgctga taatccacta aaggctttga cctgacgtct 2199061 cccgctttcg gcgcttccaa aatcggatta gacgagctgt ttgccagcag tagatcgccg 2199121 ccaagcatcc ttccgctttt ttcatggaac agaacaatat gcgattcagc atgtccaggc 2199181 atctccaaca cagaccagcc ctcaagccca tctatgccca taccttctct gattgatttt 2199241 gtcagagatc tcgtacagga aaatgcgtac gctgatcgaa tcagcttttc cgccttcccc 2199301 gtatcaaatg gaacgcctaa ttcaggcagc agcttttgaa aaaaacgttt ttgccaatcc 2199361 ataaaggctt gattttggct gatataaggt tcgttgaatg tatgcccaat cacttcgatt 2199421 tcatctgaaa agacatcaag caagcctgca tgatcagcat gatggtgagt cagtacaacc 2199481 tgctcgatat ctgacaattt cacatttaca gcggcaagct gctcttgtaa ggctctggca 2199541 gcctcttttg tattcggccc ggcatcgata agtgtcagcg catcaccttt tacgaggtaa 2199601 acgataacat cgccgacagc aaacggtgtc gggacgcgga tcgcaattac atcttcagtt 2199661 gtcatccttt cgctccttgt cttcattcat tattcatatt ttagcttttt ctcggtcttg 2199721 tgtcattatt gcagaatgag aacaaacctt tttgaaaaag ctattgacat tagcttgtcc 2199781 gccattgcat aatgaacaac aaactaaaac gagaaccatt ggaacgctat gacgaggaat 2199841 agtatacaag gcaatggcct aagagagcga tacccccggc tgaaaggtgt tgcggcccgc 2199901 ttgtttgtag aacctgccct caagtcgcgg ttaggaaaac ctaaacgttt cccgcgttac 2199961 ggggatttga gctgagcaca atttgtgcta atgagggtgg taccgcgaac cttttcgtcc 2200021 tttacgtgat gaaaaggttt tttgttgttc taatagaagg aggatatcaa tgaaaaagat 2200081 aggatttgtc ggcgccgggt caatggcaga agcaatgatc aacggcattt tgcaaagcgg 2200141 catcacaaaa ccagaacata tctatattac aaatcgctca aatgacgagc gtctgattga 2200201 attaaaggaa acgtacagcg tgcgtccatg cagagataaa aatgagtttt tcactcacac 2200261 cgatatcatt atcctcgctt tcaaaccgaa agacgcggcg gaaagcatcg acagcatccg 2200321 gccgtatatc aaggaccagc ttgtcatttc agtacttgca ggccttacca tcgaaaccat 2200381 tcagcattat tttggcagaa agctcgcggt cattcgcgtc atgcctaata catcagcggc 2200441 aatcagaaaa tcagcaaccg gattttccgt aagcacggaa gcaagcaaga atgatattat 2200501 tgccgcaaaa gctctattgg aaacaatcgg tgatgcaaca ctggttgagg agcggcatct 2200561 tgacgctgtc actgcaatcg caggcagcgg cccggcctat gtgtatcgtt atattgaggc 2200621 gatggaaaaa gcagcacaaa aagtaggatt agataaagaa acggcaaaag cactcatttt 2200681 gcagacaatg gcaggggcaa cagatatgct cctccaaagc ggcaaacagc cggaaaagct 2200741 gcgtaaagaa atcaccagtc ctgggggcac tacagaggca ggtcttcgcg ctttacagga 2200801 ctcccgcttt gaagaagcaa ttattcactg tattgaagaa acagctaaac ggagcgcaga 2200861 aatcaaagaa cagtttgccg gtgccgcctt agagagacat tcttagatgt aaggacaaaa 2200921 acagaaggca cagtgccttc tgttttttat ttttcccgca gcagctggcc ggcagattct 2200981 gattgcttta atagcgcgga gatcgtaaat gaaagcaaat cgggaagcac ttcaaaggaa 2201041 taaggcatat acaatctttc cgtccattta tgcgggtctt taccagccgg accgacattt 2201101 aaaactggga catataaagc ctgattttta ccgcttggca atgaataccc tctgttaaag 2201161 agcggcatat tgcttgtgta tgcatcaacc tcctgttttt ccagctgaag ataactcaag 2201221 tccgaaagtc cggggaagta ctgaacctcc cgtaatgcaa tgccgtatcg ctcagccgca 2201281 taatgcttta tctgatctgc tgtatttctg atcaattgat catcctttga agaaacagct 2201341 ggataaagcg gcggactata aaacagaacg atgagcggcg catcctcctt acaaagcgaa 2201401 gcaagctcag aaacaatttt cgtcgaaaaa tccctgtctc caagctcccc cctgttagca 2201461 aaggcataat ttagagcccg ctctgtttcc gagatccccg cacgcttttt tgcacgcgag 2201521 accagctcat caaatgtcaa aacagtgacg tcccgctcaa tcggctgaaa tggctcaaat 2201581 tgttgaaaat cctgtgtttt cttccgaacg ttcgacatga tttcctccgc cgcctgttct 2201641 gctgttttaa gcagcatctg atgcagctca ctagctgagc gtttcattga cagcacatta 2201701 aataatgtga cggctgtatg cggtgtctgg actgaatatg cctctttcaa gtccttttgc 2201761 attaagttta ccggcggcgg agtgacctcg ccatcaacct tttcgcaata atcagcattc 2201821 agttcaagca aacggttaat ctcagatacc attaaatttg cgtttagacc tgaaaacggc 2201881 tctccaacat gtgtctcaat ccccttgcag aaaaaacccg caagcacctt gccaatgctt 2201941 cctgtataaa aatattgctg ctgatcgccg ggaaattttt caaacatcgg ttcggcattc 2202001 aggcaagcgg ttaatgtgat atcatgcttt ttctccatct ccttcaatgc aggaaccgct 2202061 tcaatcatgc ctcttgaatt cacttcctcg tccggaaccg ttatcaacag cagattgccc 2202121 tcaaaatgcc cgttcattgc cctctccagc atcgacagtt gaatacaaag ccccgctttc 2202181 atatccatcg tccctcttcc gaacagccag tctccgcttt cggcatctct tctcacacgt 2202241 tccgggagca gctctttttt ctctaaaaag gagctcaaaa gctcagcagg cttgcaagcc 2202301 atatgtttaa attcgccgta atcttctatg tcaacgacat caaaatgact cagcagaagc 2202361 actgtctttt tgacattctt ctttttgact agagccgtaa gaaaagatct gccatcgtcc 2202421 atcggatgaa gtgttacatc atcagggtgc ttttgaaaat agggcttgtc cttcaaaata 2202481 aaataaagat actctgcaag cgctacctcg ccctttgaac cggtgatgct ttcgtattgc 2202541 acaagagaag ttaaaagtgc cagcaattcg tccttcgtct gccaattcat tgattccgcc 2202601 cctcctatga ataaaaatgc ttctatactg aaaaataaac tgatttctcg tctattatac 2202661 agaaatgttt gacaaaagcg gttcatttga gcagtttata tgacgggaaa gaaatgactt 2202721 gatataatca atctctaaaa accttacggg aggcgaaaga aatggccaga aaattattta 2202781 cacctattac aattaaagat atgacgttaa aaaaccgcat tgtcatgtcg ccaatgtgca 2202841 tgtattcttc tcatgaaaag gacggaaaat taacaccgtt ccacatggca cattacatat 2202901 cgcgcgcaat cggccaggtc ggactgatta ttgtagaggc gtcagcggtt aaccctcaag 2202961 gacgaatcac tgaccaagac ttaggcattt ggagcgacga gcatattgaa ggctttgcaa 2203021 aactgactga gcaggtcaaa gaacaaggtt caaaaatcgg cattcagctt gcccatgccg 2203081 gacgtaaagc tgagcttgaa ggagatatct tcgctccatc ggcgattgcg tttgacgaac 2203141 aatcagcaac acctgtagaa atgtcagcag aaaaagtaaa agaaacggtc caggagttca 2203201 agcaagcggc tgcccgcgca aaagaagccg gctttgatgt gattgaaatt catgcggcgc 2203261 acggatattt aattcatgaa tttttgtctc cgctttccaa ccatcgaaca gatgaatatg 2203321 gcggctcacc tgaaaaccgc tatcgtttct tgagagagat cattgatgaa gtcaaacaag 2203381 tatgggacgg tcctttattt gtccgtgtat ctgcttctga ctacactgat aaaggcttag 2203441 acattgccga tcacatcggt tttgcaaaat ggatgaagga gcagggtgtt gacttaattg 2203501 actgcagctc aggcgccctt gttcacgcag acattaacgt attccctggc tatcaggtca 2203561 gcttcgctga gaaaatccgt gaacaggcgg acatggctac tggtgccgtc ggcatgatta 2203621 cagacggttc aatggctgaa gaaattctgc aaaacggacg tgccgacctc atctttatcg 2203681 gcagagagct tttgcgggat ccattttttg caagaactgc tgcgaaacag ctcaatacag 2203741 agattccggc ccctgttcaa tacgaaagag gctggtaatg cccataagag atatcctgta 2203801 gaggatatct ctttttttat ttttagagaa acgatcggct aaggttctcc gtctccctag 2203861 tagaaccaat tagaggagat gactccaatg aaatcagctt ggatggaaaa gacatataca 2203921 attgacggat gtgcgtttca tacacagcac cggaaaggat caagcggtgt aacgattgtc 2203981 tttgaggccg gctatggtac ttcttctgag acgtggaaac cattaatggc ggacattgat 2204041 gatgaatttg gcattttcac atatgatcgg gcaggcatag gaaaaagcgg gcaaagcaga 2204101 gctaaacgaa cagctgatca acaagtgaaa gaattggaga gtttgcttaa agcagctgat 2204161 gtaaaacctc cttatttggc tgtttcacac tcatacggag ctgtcatcac cggtttatgg 2204221 gcctgcaaaa acaagcatga tattatcggc atggtccttc ttgacccagc tttaggcgat 2204281 tgcgccagct ttacctttat acccgaagaa atgcacaaat cacatacgag aaagatgatg 2204341 cttgagggca cacatgcaga gttttcaaaa agtctgcagg agctcaaaaa gcggcaagtc 2204401 cacttaggaa acatgcctct tcttgtgttg tcatcaggag aacggactga gaaattcgct 2204461 gctgaacagg agtggcaaaa cttgcacagc agcatattgt ctctatctaa ccaaagcggc 2204521 tggattcaag ctaaaaacag ctcccacaac atccatcatg atgaacctca tatcgttcac 2204581 ttggctattt atgacgtatg gtgcgcagcg tgccagcagg ccgctcctct ttaccaggca 2204641 gtcaattaac gtaaaaaaag accgggccgt aagggattcc cggtctttta tattattttg 2204701 tttcacggtg aagggtatat ttctttaaac gcggtgaata ttttttcagc tccaaacggt 2204761 ctggattggt gcgtttattt tttgttgtga tgtaatttcg gtctcccgtt tcagtgcaaa 2204821 gctaaagtaa catttactct cataattaac atctccttat aaaacgtaat gattacgttt 2204881 tattatacaa cgtcatcaca aattgtcaaa taagagctcc gccttcagcc tcgcgggacg 2204941 tttacctcta agaaatcata tgccgccacg ctattgggga aaacgtcaac cgcttctttt 2205001 tgaagctcca aagaagcatc tccctgatat cttgcgctga tatgggttaa aatgagctgc 2205061 ttcgctcttg cttctttcgc tgttacagcc gcttgttccg ttgtactgtg ataataatca 2205121 taagcaagtt tacggtcttc cttagcaaag gttgcttcat gaacaagcac atcacaatcc 2205181 ctcgcaagct cttttagttt gtcacttact ctcgtatcac cggagaacac aacagatctt 2205241 ccctttttag gaggctccag aaaatcattc ccattgatga ttcgtccgtc ttcaagcgtt 2205301 accgtttcgc cttttttgat tttctgatat acaggtccgg gcgggatgtt catttctttt 2205361 aatacgtcag ccttcaagga acccggtacg tctttttcct gcacacggta cccgaaggct 2205421 tccactccat gaataacaga taccgctgtg acaataaact gatcgtcctc aaacacgatt 2205481 ccttcttcaa tttcctggat cgcaagcgga tatgtcaaat gggttttcgt gacggcaagg 2205541 cttgtttcaa taaacgcctt gatcccttta ggtccgtaca ctgtcagctc gtcctctccg 2205601 ccttgaaagg aacggctccc cagaagcccc ggaagtccgt atacatgatc gccgtgcatg 2205661 tgtgtaataa agattttctc tattttacga ggtttaatcg ttgtatgtaa aatttgatgc 2205721 tgtgtggctt ccccgcagtc aaaaagccat accgaacgcc tttcttcaag caattttaat 2205781 gccaccgacg ttacatttct cgccttggcg gggatgccgg ctcccgtccc taaaaaaagt 2205841 aattccacgt ttccttcctc ctactagaac cagataccta caagaataca ggatcaagcg 2205901 gaaaatgtga atcttgcctc tgaaaagaac aatcctttcg tgctagaaac attttttcag 2205961 cattctgctt aaaaaagggc ttaaatgttt gctttcgttg aattttagat ttaaaatgaa 2206021 ggaaatatac ggggtgtact aaaataaagc ttcgaataaa gtgaggtact tttagtgaaa 2206081 acaaaccaac aaccaaaagc agtaattgtc atattcggtg caactggaga tttagcaaaa 2206141 cgaaaattgt atccgtctat tcaccgttta tatcaaaacg gacaaatcgg agaagagttt 2206201 gcagtggtag gagttggaag aagaccttgg tctaatgagg atcttcgcca aactgttaaa 2206261 acatccattt cctcatctgc agataagcat atagatgatt tcacgtctca tttttactat 2206321 cacccgtttg acgtgacaaa ccctggttct tatcaagagc taaacgtatt gcttaaccag 2206381 ctggaagata catatcaaat tcctaacaac agaatgttct acttggcaat ggctcctgaa 2206441 ttcttcggaa cgattgcaaa aacattaaaa tcagagggtg taacagctac aaccggctgg 2206501 tcccgccttg tcatcgaaaa accgttcggc catgatctgc caagcgcaca ggcattgaat 2206561 aaagaaatcc gcgaagcatt tacggaagat caaatttaca gaatcgacca ttatctaggc 2206621 aaacaaatgg ttcagaacat tgaagtgatt cgatttgcca atgcgatttt cgaaccgctt 2206681 tggacaaacc gctacatttc aaacattcaa atcacatcta gcgaatcact aggcgttgaa 2206741 gaccgcgcaa gatattacga aaaatcaggc gcccttcgcg acatggtgca aaaccatatt 2206801 atgcagatgg ttgcccttct tgcaatggag ccgcctatca aattgaacac agaagaaatc 2206861 cgcagcgaga aagtgaaggt gctgagagca ctgcgtccta ttgcaaaaga cgaagtggat 2206921 gaatactttg tgcgcggaca atatcatgct ggtgaaattg acggtgtacc ggttcctgct 2206981 tatacagatg aagataatgt cgctcctgac tccaatacag aaacctttgt tgccggcaag 2207041 ctcttgatcg acaacttcag atgggctggt gttccattct acatcagaac cggaaaacga 2207101 atgaaagaaa agtccacaaa aattgtcgtt caatttaagg acattccgat gaacctgtac 2207161 tacggtaatg aaaacaacat gaatccgaac ttgcttgtca ttcatattca gcctgacgaa 2207221 ggcattacgc tttacttaaa tgctaaaaag cttggcggag cagcacacgc acagccaatc 2207281 aaactcgatt attgcagcaa ttgcaatgac gagttgaaca cccctgaagc atatgaaaaa 2207341 ctaattcacg actgtcttct tggcgatgca acaaactttg cacactggga tgaagttgcc 2207401 ctttcttgga gctttgtcga ctctatttct gaaacatggg cagcaaacaa aaccttatct 2207461 cctaactacg aatcaggctc aatgggaccg aaagaatctg atgatctttt ggtgaaagac 2207521 ggcttacact ggtggaacat ataataagaa gaaaaaagcc gaaatagttt actaagcatt 2207581 ttcggtcttt tttacgctga acaaaggtat aacaatctcc ttaataacaa aacccccaaa 2207641 gcttaagagc ttcgggggtt tctattgatt acttcatcca ttcagtatgg aagatgcctt 2207701 ctttgtcagt acgctcataa gtatgagcgc caaagtagtc gcgctgtgct tggattaagt 2207761 ttgcaggcag tacggctgtg cggtagctgt catagtaggc taatgcgctt gagaatgatg 2207821 gcaccggcac accttgggca actgcaagtg aaatcacttg gcgaagcgct ccttgatagc 2207881 tttctacaat attcttgaaa tagctgtcaa gaagcaggtt gtcaagctca ggctcgcgat 2207941 cgtaagcttc tttgatcttc tgaaggaatg ccgcgcgaat gatgcaacca ccgcggaaga 2208001 tcatagcgat ttcaccatat ttcagatccc agttgtattc ttcagaagca gctttcattt 2208061 gggcaaatcc ttgcgcgtat gaacagattt tactcatgaa caacgctttt ctgaccgctt 2208121 caatcagctc ttctttattt tctgtaacag gcttcacttc tggtcctgaa agaagtccgc 2208181 tcgcttttac acgctcttcc ttcatagctg agataaagcg tgcgaataca gattcagtaa 2208241 taatcggaag cggaacgcct aagtcaagtg cgctttggct tgtccatttt cctgttcctt 2208301 tttggcctgc tttatcaaga atcacatcaa caagcggttt gcctgtttct tcgtcttttt 2208361 ttgtgaagat gtcagccgta atctcaatca ggtagctatc aagctcacct ttattccatt 2208421 cagcgaaaac ttcatgaagc tcatcagcag aaaggcccag cacctgtttc agaatgaaat 2208481 atgattcaga gatcagctgc atatctccgt attcaattcc gttgtgcacc atttttacgt 2208541 aatggccggc gccgtccgga ccgatatatg tcgtacaagg ttctccgtca acttttgcag 2208601 aaatggcttc aagaatcggt tttacaagct catgtgcttc tttttgtccg ccaggcatga 2208661 tagaaggtcc tttaagcgct ccttcttctc cgccggaaac gcctgttccg ataaaatgaa 2208721 tgccgctttc agcgagttct ttgttacggc gctgtgtatc tttatagtat gtattaccgc 2208781 cgtcaattaa aatatcatcc ttctctagat gaggaagaag agattgaatt gtcgcatctg 2208841 ttgcagttcc cgctttaacc attaataaga ttttgcgcgg tgtttccaag gattggacaa 2208901 attcttcaat gctgtaagtg ccaacaacat tttttccttt tgcctcctgt aaaaactcct 2208961 cagttttact gcttgatctg ttgtaaacag aaacagaaaa tccccggctt tcgatattta 2209021 aagccagatt tttacccatg accgcaagtc cgataacgcc gatttgttgt tttgacatat 2209081 tctaacgtcc cttctgcaaa cgtttaatca ttttaaaatt taaattaaaa taaaatgata 2209141 tttataataa agaaattacc atacattcac cctttttttc aagcgattca gcttttcttt 2209201 tcatcttgaa aaaaatcttt attaaagctt gttccctttg ttttgctctc ctcttttttt 2209261 aacgttgccc cttttctgat cagtttggta ccgtactttt tattcagctt ttccatcatc 2209321 tgctgaatgg gctcatcctt cgcatcttca ttaaagctga acaaatcgag ctgtttatag 2209381 gcctgctctt tttctactaa atccgttccg gtaatgccaa gcagcctgac aggattttta 2209441 ttccaatgtt taaaaaagag gtgctccgct tctttcaaaa tgtcattttt ttgatcaatc 2209501 gggtttctca gcgtagtgct tcttgtgatg gttctccaat ccgcatatct aatcataata 2209561 aaaagcttcg aagccatgac ttccttgcgc tgtaaacggt cactcacaga agcggcaagc 2209621 tttctaaaaa cgcctaacag ctcttcttca tcactggaat catgggaaag tgtcgatgag 2209681 ttgccgacgc ttttaaattc gtaaatgcgc tccgggtcaa ccggcgcatg gtgaatgcca 2209741 tttgctttat ttttaaggcg cggaccgttg atgccaagca ggcgcttcag cgagtgttca 2209801 tcagctgcag ctagctctcc gattgtatgg atgccgagtc ccttcagttt ttccgctgtc 2209861 tttttgccga ctccgtgcat ctctccaaca ggaagcggcc acaggatatc gggcacttgc 2209921 ctctttctta agatcgtaat tccaagcggt tttttcatat cagacgccat cttagcgaga 2209981 aatttattcg gtgcaatccc tatgcttgac gggagcagca gctctttttg cagcctgctt 2210041 tggatttctt ttgccgtctc tagagcgcgg ctgctgtatg gtgtatcggt catgtccata 2210101 tagccttcgt cgatggagac aggctccact aggtcagtat attcacgaag aatggtaaac 2210161 atcgctcgtg aagagtttct atagcggtca aagttcggcg gaagaacgat gagctcagga 2210221 caatggcgct tcgcttgcca aaccggcatc gttgttttga cgccgcgcgc tcttgcttcg 2210281 tagctgcatg ttaccacaat gccctttcgc tcctttacgt ttccggcaac tgcgaccggc 2210341 tttccccgga gagccggatc atatgccatt tcaaccgacg cataaaagct attcatatca 2210401 atatggaaaa taattcggct ctttcccggc ataaacaaat ctccttttcg gtcattagac 2210461 aacagcttgt acatatagta aaatgaagct attgaatgga tgtgatgaca atgtttgtgg 2210521 aatcgataaa tgacgtttta ttcttagtcg attttttcac aattattctt cctgctctaa 2210581 cggcaatcgg gattgcattc ctcttacggg agtgccgtgc gggcgagcaa tggaaatcaa 2210641 aacgaacaga tgaacatcag acggtctttc acattaaccg aacagacttt cttattatta 2210701 tatatcatcg cattacaact tggatacgta aagtcttccg catgaattcg cctgtgaacg 2210761 atgaggaaga cgccggttct cttcttttat aaaccgcatt tataaaaagg aggagaacaa 2210821 aattgttaaa aacatatcaa aaacttttgg ctatgggtat ctttttgatc gtattatgct 2210881 cgggcaatgc tgcatttgca gcgactaatc aggtgggagg cctcagcaac gtaggttttt 2210941 tccacgatta tttaatcgaa ccgttttccg ctctgcttaa gggtgttgcc gggctgtttc 2211001 acggagaata cggactctct attatcctcg taaccattat tgtgcgtata gttgtattgc 2211061 ctttgtttgt caatcagttc aaaaaacagc gcatcttcca agagaaaatg gccgttatta 2211121 aacctcaggt tgacagtatc caggttaagt tgaaaaagac gaaggacccg gaaaagcaaa 2211181 aagagctgca aatggaaatg atgaagctgt atcaggagca taatatcaac ccgcttgcga 2211241 tgggctgtct tccaatgctg attcagtctc cgattatgat tgggctttat tacgcgattc 2211301 gctcaacacc tgaaattgcg tcacactcgt ttctatggtt cagtttaggg caatctgata 2211361 ttctcatgtc ccttagtgca gggattatgt attttgtcca agcctatatc gctcaaaaac 2211421 tgagcgcgaa atattccgct gtcccgcaaa accctgcagc gcagcaatcc gcaaaattga 2211481 tggtgttcat cttccctgtg atgatgacga ttttctcgct taatgtgccg gcagcccttc 2211541 cgctgtactg gtttacaagc ggactgtttt tgacagtgca aaacatcgtc cttcagatga 2211601 cgcatcataa aagtaaaaaa acagccgctc ttactgagtc ggtgaaataa aaaagcaacc 2211661 ccgtgcaaaa agccggggtt gttttttgtt acttgcaaag taccgcgcca aacagtcttg 2211721 tttatcatgg ctgaagcaga aatggccatc ctaaaaaata gccgtatcgt ttaaaaagaa 2211781 ggaaatcggg aataccttta ctcacctcca accgaaagga gcctatacgt tgacggaacg 2211841 ctttcagcaa aaaaatattt ctgtacctga tggaatctgg atcatgagac aaacctggaa 2211901 tgatgtctta tttgctcact ggcctgttga tgtttctatc cttcgcgctt tggtaccgtc 2211961 cgttttagaa ttagatacat ataacgggca agcttggatc agcatgcttc cctttatgct 2212021 cacgaacctg agggcgcgtt atctccctgt cattcccggt gcgcgtgcat ttcctgagct 2212081 taacctccgc acctatgtca cgtataaagg caagcccggc atttattttt ttagcttaga 2212141 tgccgatcat cgtctggcgg tccttggcgc tcgcacattc tttcatctgc cttattttta 2212201 cgcggatatg aagtccgaaa aaaacggtga tgccattgac tatgtcagca agcggaaaaa 2212261 tgacaaagaa gcagcattcc acgccgcata ccggccaatt tcagcgcctt ttacagcaga 2212321 aaaggattcg ctcgattact ggctgacaga acgatacagg ctctacacca cttatcgcaa 2212381 taagctctat tacgaagaca tccatcatca tccgtggctg ctgcaaaacg ccgaagcaga 2212441 aatttcagtc aatacggtga ctgatgctca cggtattaca ttgccggagt cagacccctt 2212501 gcttcattat gctaaaaaac aggatgtgtt attttggccg cttaggaaat ggagctaaaa 2212561 aaacccgatg cgggaaatcg cactcgggtt ttcttttttt attttgccgc ctcttcaata 2212621 atggcaacaa ccatttctgc cgttttaacg agctcttcga tcggcatttt ttcatttttt 2212681 gtatggattt gctcataacc gacagcaaga ttgaccgtcg ggatgccatg accagcgatt 2212741 acgttcgcgt cgcttccgcc gccgctcgtt tgcagctcgc ttggacgtcc gattttagca 2212801 gccgcttttt tcgcgatttc aacaacttgg tcgccgtctt gatatttaaa gcccggatac 2212861 ataacctcaa tttcgacttc tgcgcgtccg cccatatcag cagctgcctc ttcaaaagca 2212921 gctttcattt tttgaacctg agcttccatt ttctcaggaa ctaaagagcg cgcttcagca 2212981 agaatatgaa cttcgtcgca cacaatgttt gtttgtgtgc cgccttcaaa ccggccgata 2213041 ttagctgttg tttcttcatc gatacggccc aatggcattt ttgagatggc tttgctagcg 2213101 attgtaatcg ctgaaatgcc tttttcaggt tcaaccccgg cgtgagcggt tttcccgaaa 2213161 attgccgctc ttaccttcgc ctgtgtcggc gcggccacaa tgatatttcc gacttttccg 2213221 tctgaatcaa gagcatagcc gtaggatgca gtgatcatag aacggtcaag cgccttcgct 2213281 ccgatcagac ccgattcttc ccctactgtg atgatgaatt caatcgtgcc gtgttcaata 2213341 ttttcttctt tcagcacctt aatcgcctca aacattgcag ccaatcccgc tttatcatca 2213401 gcacctaaaa tcgtcgtgcc gtcagttttg acgtaaccgt tctctacaac tggttttacg 2213461 ccgtttccgg gtacaactgt gtccatatga gatgtaaaat agatcgtatc tgtttgtttt 2213521 gtccctttta gcgtgcaaat caggttaccg gctccgtggc ccgtgatatc cattgtatcg 2213581 tcttctttaa cgtccacacc taaatcagaa aattttcgtt tcagcacttt gcagatttca 2213641 gcttcgtgct ttgtttctga gtcaatttgg acaagctcta aaaattcttc cagcaggcgt 2213701 ttttcattca ccatttgtaa gtccctccat attaaagcgg tatgttaccg tgcttttttt 2213761 tcggtctctc ttctgtctta tgtgtaagca tatgaaaagc ttgaatcagt cttccccttg 2213821 attcttccgg caaaatgatg tcatcgacca ttccacaagc ggccgctttg tatgggccgg 2213881 cgttttgctt tttgtattca gcagtttttt cgcgtttcgt cttttgcggg tcagctgaag 2213941 ctttgatttc cttttcatac aaaatcgatg ccgcaccttc tggacccatc actgcgattt 2214001 cagcattcgg ccatgcaaac acaaggtccg ctccgatcgc tttgctgttc atggccacat 2214061 aggcgccgcc gtacgctttt ctaatgatga gtgtgacttt tgggacagtc gcttcagcat 2214121 aagcaaacaa taattttgct ccatgcctga tgattccgtt gtgctcttgc tgaatacccg 2214181 gcagaaaccc cgggacatct tcgacagtca acagcgggat atcaaatgcg tcacaaaaac 2214241 ggatgaacct tgctgcttta tcagcagcgt caatcgtcag gcttcccgcc agatgcttcg 2214301 gctggctcgc cacgatgccg attgcttttt cacccagcct tgcaaaccca atgacaatgt 2214361 tcttcgcaaa aaatggctga atctcaaaaa aagactgcgg gtcagccagc tccctaatca 2214421 ccttccgaac atcataaggc tttgtcgtat cagcagggac aagacggttt aataacggtc 2214481 tggacgcctc tttctctggc ttcggctctg ttgtccggcc attcagcggc aaataagaca 2214541 gtagttttct cacccctgtc agaacctcct tctccgtatg cccggaaaag tgggcgtttc 2214601 cgctgacggc attatgtatc cccgctccgc ctaagctctc cgcatcaacc tgttcccctg 2214661 tcactttttc aatcaccttc gggccggtaa taaacatccg gccagtctgt tcagccataa 2214721 atataaaatc tgtgagtgcc ggagaatata cagcgcctcc agcgcacggc cctaaaataa 2214781 ccgatatttg cggaatgact ccggaatata agacgtttcg gtaaaatatg tgaccgtatc 2214841 catctaatga taacacaccc tcttgaattc tcgcaccacc tgagtcattc agcccgataa 2214901 tcggcgcctt attttttgct gccagatcca tcaaagcgca gattttcctg gcatgggttt 2214961 cgccaagcgc ccctccgtac actgtgaagt cttgcgcaaa tacataaact gagcgaccgt 2215021 caattgtgcc gtaccctgtc acgaccccat cccctaacat gcgctgttct cttgttaaca 2215081 cttgactttc catgaagggg tgtaattcga taaagctgtc ctgatctaga agaaatatga 2215141 tcctttcccg agcagtgagc ttgccctttt gccgctgctg agccagcttt tcccgtcctc 2215201 cgccttcttc tgcctgcttg cgtttcgtgt aaaaatgatc catgtgctca ttcatgctca 2215261 ttgtgttggt ctcctttcgg ttcacaaagc tctacaagaa caccgtttgt ttcccgaggg 2215321 gaaataaacg cgatcttttt cccgttcgct ccctgtcttg gaaacctgtc aatcaattga 2215381 acatgctgat cagacaatgc ttgaagctgt tcagataggc agttgcacaa aaacgcaata 2215441 tgatgcagtc cctgcccttt cttctccaaa aataaatgga cggggctgtc agctgtcaac 2215501 ggctctatca gctcaagttt gacgctacca gcttgaaaaa aagcaacatt caccttttgc 2215561 tcttcaaccg tttcttgatg aagaaatgca agccccaata cattttcata aaagcttctt 2215621 gcatctttta tcgaaaaaac ggctatcccg atatggtcaa gcctgttcat tttcatccct 2215681 gctttcgcta atagatatcg cttgtccgcc cattcaaaac acgctaaaat atagacagat 2215741 tgtttaagga gtgaaaatca tgtctcaaaa actgatgaaa agcgttttga tcgtgatttt 2215801 gggagttttt attctttcaa ctgtactctc aggaatcgtc atgtttctat aacgataaaa 2215861 aagcaggcgc cttattcaat gggaatatcc tgctttttta tcagagcttt atgctcgatg 2215921 gcaatctcct caaaagagcg gttgtcgtcc gtgatcagca ctctcgttcc tactggtatc 2215981 gtttgaaaca aatgaacaac ctcatcgtta tgcatacgta tacagccgtt agacacaaat 2216041 tttcctactg attcctctcg gtttgtccca tgaattccat aaatccgccc gtccgttcct 2216101 ttcgcgtcaa atccgatcca tcttgcccca agcgggttat caggagatcc cccttcaata 2216161 tttttctttc tgtagtaagg attttccgct tttaccgtta ccgaaaactc tccttcaggc 2216221 gtcaaatcat ctgtttttcc agtcgccaca ctatacacgc cttctacttt gttgtcgagg 2216281 ataacagcaa gttcatttgt tcgcttgttg acaataacat acggatcacc cggcagcgga 2216341 ttttcgccga gcggccaaat cggtgaaatc atcatgaaaa tcgaacataa gaaaaaacgc 2216401 ataagctcct cctttttcat taggttgacc aatgaaggaa gagctcatgc gaatcatccg 2216461 agtgattttt gcgcttttat tcctttaaaa taacttttaa tcactaaata ttgttccatt 2216521 tcgccgagaa gatggaagag agcggccctc gcttcaaatt cctctctagt cgcaggaagc 2216581 ggcatctcct caaattcttt tctcatgtca gcaagtcttt tcagaaattt gtatgctgta 2216641 ttcccagggt gtatcgcctc ccgcaaatca tgaataaatt cagcgatcat ttttccctga 2216701 tctaccgtga tggagatcga tgtcacttta gggagaaggc gttcgataat ttcaaattgc 2216761 ttttctctca ttttaaaata atgataatgc agattttcat aacgcaaaat gtggttttgc 2216821 acatctcgat atgccaggtt tttagcctcc gtaatgagct ggtgcgtttc cggaatttct 2216881 tttcctgacc aatcttgctc accagttaac aaataccgtt cgatttctgc aaaaatgaca 2216941 gcaaagttat cctctatctt tttgcggtag gcaatcagtt tccggtcaag actaggcata 2217001 tacaagttca tcaatagagc gacgccgatg ccaaccgtaa tcagctgaac ttcattccag 2217061 atgaaagtag gcgtaatgcc gccggacatg tataaatgaa ggataataac agaactggtg 2217121 acgataccct cgttaatttt taacagaacc gttatcggaa tgaatatcaa aagaagcgct 2217181 ccgatcacaa acgggtggta gccaataagc tcgaaaaaga gataagaaaa agcaattgcc 2217241 agacagcatg ccgaaaagcg ggcccatgag gcctgaagcg accgtttttg tgtgatttgt 2217301 atgcacaaaa tggtgatgat tcctgctgat gcgaagtttt gcaaatgcaa taactggctt 2217361 atataaatag ccaaagctgt tccaagcgcg gtctttattg tgcggtaacc aattttaaac 2217421 atgtcggact ccatttctat ttgtttcttc aataaaaaag aagaggcggc cagccttctt 2217481 cttttttata ttctataata ttttctctaa aaagtcctgc gctcttttgg attttggcga 2217541 cataaaaaat tccttcggat tgccgtcttc gacaatcatt ccttggtcca taaacagcac 2217601 acggtctgcc acttcttttg cgaagcccat ttcatgtgtg acaatcacca tggtcatgcc 2217661 ggtttcgacc agctctttca tcacctgtag cacttctttg accatctctg gatcaagggc 2217721 ggaggtcggc tcgtcaaaca gcatgatgtc cggattcatc gcaagagccc tggcaatcgc 2217781 gacacgctgt ttttgtccgc cagacaaacg gtttggatag tcatttcgct tttcaaacaa 2217841 accgactttg cggagcaggt cctcagcttt ctcctgtgca gcctgttttg attctttttt 2217901 tacattgaca ggcgcgtaca tgatgttttc gagaaccgtt ttgtgcggaa agagatgaaa 2217961 atgctgaaaa accatcccga tgttttcccg gacctttaat gtgttggttt tcggcttcgt 2218021 aatctctgtg tcttttattg taatggttcc gccgttaggc ttttccaaca ggtttaaaca 2218081 gcgtaagaac gttgatttgc ctgagcctga aggaccgatc acggcaacaa cctcaccctc 2218141 agcgattgtt gttgaaatgt tttttaatac ttcgtgtttc ccaaatgatt ttgacagctt 2218201 ttcaacctta atcattggat ttcagcttcc tttctacagc cttgccgata aacgttaaaa 2218261 tcaggacaag cacataataa atcaatcccg cgataatgag cggctcaagg taattgtaag 2218321 tggcggcgcc agcttgatat gcgcgtctca tgacatcacc aagcccgatg acggtgacga 2218381 tcgccgattc ttttgttaac gtaattaatt cattcacaat tgcaggtgat atatttttga 2218441 aggcctgcgg cagcagcaga tccttcatca tttttccata cgggacaccg agtgcaacag 2218501 cagcttcttt ttgcccttta tcaatggcat tgattccggc tctgataatt tccgatacat 2218561 aagcggcgga attcaaagac aatgcgacaa ccgcagccca aaactggtca atttgaaatc 2218621 cgagcagctg aggaaggcca aaatagacaa tcataagctg cagcactaaa ggcgtgcctc 2218681 ggaacactga tgtataaaaa tcagcgatcc agataaacgg gcggaatgtg ctgatcttgc 2218741 ataagcttag cacaataccg agtataagtc cgataatagc agatacaaca acaattttta 2218801 atgtaattgc caagccttct aatataaaag gaatttgggg gatcgttgct gaaaaatcca 2218861 aattcatagc ctttgtctcc ttttcttaca ggaaaaaagt ttcctattca ataaaaaggc 2218921 tcaacgaaaa agttgagccg ctttttttta cttctcgcca gtgaaccatt ttttcttcaa 2218981 tttctcaagc tctccgttat cttccatttc cttgagcgct ttattgaatt tgtctgtcag 2219041 ttcactgtcc tttctgaaag caattgctga accggcttct tccgctttcg catcaggaat 2219101 cacaaagcct tgcaggtcat catttgattt gaaataccct tctgcaacaa tgtcttcaat 2219161 aatcgcggca tcgaagcggt cagatttgat ttcctgcacc aaatcagaaa ttctgttgcg 2219221 gtcttctgtt ttaaaaccat attccggaga aagctctttc cccttctctt cctgaataga 2219281 gccaagctga acgccaactg tttttccttt caggtctttc aaagattgaa tgccgctgtc 2219341 ttttttgctg acaatcatat ggttcgctgt gtaatacaca tcggaaaaat caacttgttt 2219401 tttacgctca ggcgttggtg tcattcctga cagaacgaga tccacctgtt ttgatttaag 2219461 cgctgtaatt aagctgttga agtccatatc ctgcacttca atttcatagc ctgccttctt 2219521 tgccagagct tttgccagct ctacatcaaa gccgacaata ttatctcctt ctttatattc 2219581 aaacggtttg taatccgccg aagtacccat aattaatttt ttctttccgc tttctgaacc 2219641 tgaattgctt gagccgcacg cagttaatgc aaaggtgatg caagcagcca caagtaataa 2219701 gagccatttt ttcatgatcc atttcccccg tattcattac ttttggtgta tttgaatatt 2219761 tattcgttaa tttgtatttt aaacagtttc tcatttttat gcaatactat ttttaaaaat 2219821 tatctttagg cttatctttc cagtgatctc ttctgatatt actagataaa aattaaatcg 2219881 ctgtacaatc cgattgaata atcccttaat atttattcat atatccttgg aaatttatgc 2219941 acaaaaaaac ccgggctgct ttgagcatcc gggttgttcg tcttatactt cttcacaata 2220001 ttcttcaaag gcttcctgca gctttgccac tacagccatc ggctcatggc cttcaatttc 2220061 atgacgctct accattttca tgatctttcc gtctttcaaa atcgcaaagg acggagaaga 2220121 tggtggataa ccttcaaaat agtcacgcgc acgcgctgtc gcttctttat cctgtccggc 2220181 aaaaacggtg acgagctgat caggtctttt atcatagtga acggaatggt aggctgccgg 2220241 tcttgcaatt cctccggcgc atccgcaaac agagtttacc atgacgagcg tcgttccttt 2220301 tttcgtaagt gcctcatcca cctcttcggc tgttttaagc tcggtgtatc cggcagctgt 2220361 tatttcttgt ctcgcttggc ggacaatatc attcataaat aaattaaagt ccatgttcaa 2220421 tgaagacctc tcctttttca tcatctgttc ttatgatagc aaggaaacgt ccatatcggc 2220481 aaatgacttt gcttcgccgt gcactttttt tgctcttcgt ttactgctta cagaaaaagg 2220541 ggattatata accagaagta aaataaagga gcagttgtat atgagccacc ggaaagcgtt 2220601 actgattcat aacggaaatg ccggcaacaa aaatatagaa aaagcacttg gtgctgtggt 2220661 gccggtttta tctcaccatt tagatgaggt gattattaaa cagacaaaga aaaaggatga 2220721 tgcgtatcat ttttgccgat ccattgatga ttctgtcgac accgtcttca ttctcggcgg 2220781 cgacggcacg atccatcaat gcataaatgc tatcagcgct ctagaaagaa aacccgctgt 2220841 cggaattttg cccggcggca cgtgcaacga cttttcaaga gtgcttggca tccctcaaaa 2220901 tcttgcaaag gccgcggaag cacttatggc gggaaaaaaa accagcgtag acgtatgtca 2220961 gatgaatgac cgttattttt tgaatttctg ggggatcggc ttaattgcag aaacgtcgaa 2221021 tcaaatcaac gaaacggaaa aagcattatt gggaaaaatc agctatttta caagtgcctt 2221081 gcgaaccgtc tcatctgctg catcgtttcc gatgacatta aaaattgatg gagaagaaat 2221141 taaagaagaa gccgttatgc tgcttgtgat gaatggccaa tacattggaa cgaatcgaat 2221201 tcctctgccc gatgccagta ttgaagacgg cttacttgat gttctcatat gccgcaatac 2221261 caacctcacc gcgctgcggg agctgatgag catggaacaa ggctcaattg atcgttttac 2221321 tggagagttg tcctatgtcc aggcttcccg tatcgagatt gaaacagaca ctgccaaaaa 2221381 ggcggatatg gatggagaag tttatacaca tacacccgca gtcattcagg tcctgccaca 2221441 gcatatcgac atgcttgttc ccgcaaatga ataactgtca taaggcttta gaaagatttt 2221501 gcaaatccgt tgactctccc ctaggaggag gtcttacagt ataagggata cacacttgaa 2221561 aaaggggaag tcatatggag aagaaaaata ttaccttaac tatattatta accaatttat 2221621 ttattgcttt tttggggatc gggcttgtga ttccagtaac gccgaccatt atgaatgaat 2221681 tgcatttatc ggggaccgcg gtcggctata tggttgcctg cttcgctatt acacagctca 2221741 ttgtctcacc aatagccgga cgatgggttg atcgcttcgg gcgcaagatc atgatcgtaa 2221801 tcggcctgtt gttctttagt gtgtcggagt ttttgttcgg cattggaaaa acagttgaga 2221861 tgttatttat ctcccgtatg ctgggcggta tcagcgcagc cttcattatg cccggggtca 2221921 cggcttttat tgcagatatc acgaccatta aaacacggcc aaaagcgctc ggttatatgt 2221981 cagccgctat ttcaacagga tttattatcg gccccggcat cgggggattt ttagcagaag 2222041 tccattcccg gctgcctttt ttctttgcgg cagcttttgc actgttagca gccattttat 2222101 caatcctcac gctgcgcgag ccggaacgaa accctgaaaa tcaggaaata aaaggacaga 2222161 agacaggctt taaacgaatt tttgccccca tgtatttcat agcttttctc attatcttaa 2222221 tttcgtcttt tggtttagca tcatttgaat ctttatttgc attattcgtg gatcataaat 2222281 tcggatttac ggccagcgac attgccatta tgattacagg aggagcgatt gttggcgcca 2222341 ttacgcaagt cgtcttattc gaccgcttca caagatggtt tggcgaaatt catttaattc 2222401 ggtacagctt aattctctcg acgagtctgg tattcttgct gacaacggta cattcatatg 2222461 ttgcgattct gctggtgaca gtcaccgtat ttgtcggatt tgatctcatg cggcctgcgg 2222521 taacgactta cctgtcaaag attgcgggaa atgaacaggg gtttgccggc ggtatgaatt 2222581 caatgtttac aagtatcggc aatgtattcg ggcctattat cggcggaatg ctgttcgata 2222641 tagatgtaaa ctatcctttc tactttgcaa cggtcacctt agccataggg attgcactga 2222701 ccattgcttg gaaagcgcct gcacatctta aagccagcac gtgataagaa gcgcattctt 2222761 tgtgtactgc aaagaatgcg cttcttcttt atactgatga tagaaggagt gatggcatga 2222821 aggaatcgta ttactcaatt ggggaagtat caaaactggc aaacgtgtcg ataaaagcgc 2222881 tccgttatta cgataaaatt gatttattta aaccagccta cgtcgacccg gataccagct 2222941 accgctatta tacagattct cagctcattc atctggattt gatcaaatca ttgaaatata 2223001 tcggcacacc tttagaagag atgaaaaaag cacaggactt agagatggaa gaactgtttg 2223061 ctttttatac agagcaggag aggcaaatca gggagaaatt agacttttta tcagccctgg 2223121 agcaaaccat ttcattggtg aaaaagcgga tgaaacggca gatggaatat cccgcgctcg 2223181 gtgaggtgtt tgttttagat gaagaagaaa tacggatcat tcagacagag gcagaaggaa 2223241 tcgggcctga aaacgtgctc aacgcctcct acagcaaatt aaaaaaattt atcgagtcag 2223301 cagatggatt tacgaacaat agctacggcg ctactttctc ttttcagccc tacaccagca 2223361 ttgatgaaat gacttaccgt catattttca cacctgtatt gacgaataaa cagatttcat 2223421 caattacgcc ggatatggaa atcacaacga tccctaaagg gaggtatgcg tgtatcgcgt 2223481 ataatttttc gcctgaacat tattttctca acttacagaa gcttatcaaa tatatcgcgg 2223541 accgccaatt aacagttgtc agtgatgtat acgagttaat cataccgatt cattactccc 2223601 cgaaaaaaca agaagaatat cgagtcgaaa tgaaaatacg gatcgctgaa taataaagca 2223661 tagaaaaaga gcattttttg aaacaaaact tcaaaaaatg ctctttttgc ttatttagta 2223721 aacagatgtc ttctcgtcaa tcgattctaa aatttgtttc actcgtccga ggaatcgtcc 2223781 gcacacgaga ccgtcaagca ctctgtgatc taatgacagg cacagattaa ccatgtctct 2223841 gacagcaatc atgccattgt ccatgacaac cgggcgtttg acgatggatt ctacttgaag 2223901 aatcgcagcc tgagggtagt tgataatgcc catcgactga acagacccga acgaacctgt 2223961 gttgttgacg gtaaacgtgc ctccctgcat gtcatctgca gtgagttttc cgtctcttac 2224021 ttttttagct aggccggtaa tgtctttcgc aatgccttta attgtttttt catcagcgtt 2224081 tttaatcacc ggaacaaata aagaatcctc tgtggcaact gcaattgaaa tattgatatc 2224141 ctttttctga ataattttgt cccccgccca catgctattc atttgcggga attcttttaa 2224201 cgcctgagcg accgctttta caaaaaaggc gaagaacgtt aaattaaagc cttctgtctt 2224261 cttaaaagaa tcttttatac tgttgcgata tgcaaccata tttgtgacgt cgacttccat 2224321 catcgtccaa gcatgcggaa tttctgtttt gcttcgcttc atattggaag caattgcttt 2224381 tcttacacct gtgacaggga tttctttatc accggctgca gacgcaggat atgacgtctc 2224441 ttcttttggc tcaggttttg atgcagactt cggtgcagga gctgctgttt tcagctcctc 2224501 aggattctgt tcttgcacgc cgcctgtttc aattaagcgc tgaatatctt ttcgtgtgat 2224561 gcgcccgccg gcaccagttc ctgtcacttg atcgaggtca atgccgtgct ctccggccaa 2224621 acggagaaca gctggcgagt agcgcttttt attgggctga tcggctgctc cagcactttt 2224681 tgcaacaggg ttctcagcgg cttctgatgc tgctggctgt tcttgttttt gttcagccgg 2224741 attcgcgcct tctgtttcaa ttttgcaaat catttctccg acttgcaggg tttggccttc 2224801 ttctcccaca agctctgtta tcgtaccagt aaaagaagac ggaacctctg catttacctt 2224861 atctgtcatg acttccgcga tcggatcgta tttgttcact ttatcaccgg gggcgacaag 2224921 ccatttgctg atcgtcccct ctgttacgct ttctccaagc tgcggcatcg tcatttgttc 2224981 aattgccatg attgtatcct cccttacgtc tttaaaactc cgctaattct ctcatcgccg 2225041 cttccacttt atcagggttg accataaagt atttttccat tgtcggcgca taaggcatag 2225101 ccggaatatc aggacctgca agccgtttga tcggcgcgtc taagtcgaac agacaatgct 2225161 cggatataat tgcggctact tcgctcatga tgctgccttc ttttgtatct tctgtgacca 2225221 aaagaacctt tccagttttg gacgcagctt cgatgatggc ttctttatca agcgggtaaa 2225281 ctgttcttaa atccaccaca tgcgctgaaa tgccatcttt ttcgagacgt tctgcagctt 2225341 gtaaggcgaa gtggacacac aggccgtatg tgatcactgt gatgtcgtcg ccttcccttt 2225401 ttacgtccgc cttgccgatt ggcaggacat aatcatcagc cggaacctcg ccctttatca 2225461 gacggtatgc ccgcttgtgc tcaaaaaaca gcacggggtc ttcgtcacga actgcggctt 2225521 ttaagagccc tttcgcgtca tatggtgttg atggcatgac aattttcagt ccgggctggt 2225581 tggcgaaaat tgcttcgact gattgagaat gatacagggc tccgtgcacg cctccgccgt 2225641 atggcgctct gacgacaatc ggacagctcc agtcattgtt gctgcggtag cggattttag 2225701 ccgcttcaga aataatttgg ttgactgccg gcataatgaa atcagcaaac tgcatttcag 2225761 caatcggtct cattccgtac attgccgctc cgataccgac tcctgcgatt gcagattcag 2225821 caagcggcgt atccataacg cgctcttccc caaattgttc atagagtccc gctgtcgctt 2225881 taaacacacc gccttttctt cctacatctt ccccaaggac gaaaacgcga gaatctcgtt 2225941 ccatttcttc tttcatcgcc aaattgattg catcaatata tgacattact gacatttgtt 2226001 cttcctccct acttcgcata aacataatca agcgctgact caggagctgc atatggggcg 2226061 ttctccgctt catccgtcgc ttcatttacg attgccataa tttcatccag catggtttgt 2226121 tctatctcat cggacagcag gcctgtttcc tttaagtaag cttgataagt aagcagggga 2226181 tcactttttt tcgcttcctc tacttcttca cggcctctgt agctgctgtc atcgtcatca 2226241 ctggaatgtg gtgtaaggcg gtaagaaatc gtttcaatta atgtcgggcc ttctcctctg 2226301 cgtgcccttt cgcgtgcttc tttaaccgct tgataaactt ccagcggatc atttccattc 2226361 acagttacgc caggcatccc atagcctatg gcacggtcgg aaatgttctc acatgcgact 2226421 tgcttatcgt aaggcactga gattgcgtat ttgttgtttt cacacatgaa aataaccggc 2226481 agcttatgga cagcggcaaa gtttgcccct tcatggaaat cgccttggtt tgaagaccct 2226541 tccccgaatg taacaaaggc tgcgatatcc tttttctcca tacgtcccgc aagcgcaata 2226601 ccgactgcgt gcggcacttg cgttgtaacc ggagatgatc ccgtcacaat gcggtttttc 2226661 ttttgtccga aatgtcccgg catctggcgg cctcctgagt tcggatctgc tgcttttgca 2226721 aacccggaca tcattaagtc ctttgctgtc atgccaaacg cgagcacgac acccatgtct 2226781 ctgtagtacg gcaatacata atccatttca cggtcaagtg cgaaagccgc tcctacctgt 2226841 gctgcttcct gtccttgaca agagattaca aatggaattt tgccagaacg gtttaacagc 2226901 cacattcttt catcgatttt tcttgctaac agcatggttc tatacatatc aacggcttcc 2226961 tgatcagtca gccctagtgc ttgatgtcgg tttgtactca ttcaagcccc tcctttatgc 2227021 ttttaaaaat gaatggcttt gccatctgcg gcaagcgcag cttctccaat tgcttcagaa 2227081 agcgttggat gcgggtgaat cgtttgcccg acctcccacg gtgttgcgtc cagcactttg 2227141 gcaagacccg cttcagaaat catgtcggtg acatgcgggc caatcatatg aacgccgaga 2227201 atatcatctg tatctcggtc agccacgatt ttgacaaaac cgtcgctttc accgtataca 2227261 agcgcttttc caatcgccat aaatgggaac ttgccgattt tgacattatg cccgttcgcc 2227321 tttgcttcgt cttcggttaa gccgacactg gcagcttcag ggcttgagta aatgcacttc 2227381 ggcacaagcg tcggatcaag cggatgcgga ttgagacctg caaaatgctc aacagcaata 2227441 attccctcat gtgaagcaac gtgagctaac tgcaggccac cgattacgtc tccgattgca 2227501 taaatatgag attccttcgt ttggcagctt tcattgactg aaatcatgcc attttcagta 2227561 acaatatcgg tgttctctag gccgatgcct tcgatatttg cctgtctgcc gatggaaaca 2227621 agcattttct cagcagaata ggtaacggtt tctccgtctt tttccgcttg tatgctgata 2227681 tcgtctgatg tttttgtcat tgtgtcaggc agcacttttg cccctgttat gaactggatg 2227741 ccttttttct taagaagact ttccatttct tttgaaatct ctagatcttc agtcggcaat 2227801 atgcgatccg cgtattcaat aaccgttacc ttaacgccaa aatcatgaag catagacgcc 2227861 cattcgatac cgataacccc tccgccgaca atgatgattg actgtggcag ctcctccatt 2227921 tggagcgcct catctgaagt cagtacagac ttaccgtcca cttcaagacc cggaagcatt 2227981 ctcggtcttg atcctgttgc aatgatcact tgtttcggga tcagcatgtc attttcttcg 2228041 ccatttcccc gctcaacaga aattgttccc ggcagcggag agaagattga cggtccaagg 2228101 atacgtccat atccggtgta cacgtcaatt tttccttttt tcattaaatg atttacaccc 2228161 gctgcaagct tatcaacaac ggcttgctta cgctgctgca ctttttcaaa gttgagggac 2228221 acgccagccg tttccactcc gaattgatcg gcttcacgag ctgtccggta tacctctgcg 2228281 cttctaagca gcgctttact cgggatacag cctttatgca gacatgttcc cccgagtttt 2228341 tccttttcca caacggctgt ttttaagccg agctgagcgg ctctgatggc cgcaacataa 2228401 ccgccggtac cgccgcccag aatgactacg tcatactcag ttgccatggt gactcactcc 2228461 tgtctgtcta ttcaatacga tattgtttgg attgctcttc gccctgcaat actcttagcg 2228521 ccccttgggc aagagactgc agttcatttt cacccggata aactaaaacg tctgaaatcc 2228581 aatctatgta tgatctgata gcagaaacaa agctttttcc gtacgcaagg cctcccgtca 2228641 gcacaatcgc ttcaacttcg ccttttaacg ccgcgctggc tgccccgatt tcctttgcta 2228701 cctgatatgc catggcatca taaatgaagc gggctttttc atcgccccct tgaatcatct 2228761 gttccacttt tactgcatca tttgtaccga gatagcctaa aagtccgccg gtgccaacaa 2228821 gctttttcat gatttcttct tttgtatatt cccctgaaaa acatagatca acaagatctc 2228881 ccgcaggcac tgttcctgct cgttcaggac tgaatggtcc ctcgccgtgc aggccgttat 2228941 tgacatccac cactcgcccg cggtcatgga cgccaattgt aatacctccg cccatatggg 2229001 taataatcat tttcatgttc tcatatcgtt tgccaaggga ggctgccgct ttacgagcga 2229061 cagctttttg gtttaacgca tggaaaatgc ttttcctttc aatttcaggc atgcctgaaa 2229121 ctttcgcaag cactgacatt tcgtctacga caacagggtc gacgatatac gaagggatat 2229181 tcaggccgtc agcgatttcc cgcgcgataa tgccgccgag attagaagca tgctgaccgg 2229241 cgtagccgct tttcaaatcc tcaatcatct catcattcac tacgtaggtc ccgccttcaa 2229301 ttggccggag aaggccgcct cttgcgcaga ctgcatcaaa ctttgaaata ttgattccct 2229361 gttcatgaag cgtttcgaga atatggtttt tacgaaattc atactgatca ataattcggt 2229421 caaatcgctg cagctcttct atgttgtgtc tcaatgtttt ttcaaaaatg cttctttcgt 2229481 tatgaaaaac accgattttc gttgaagttg agcctggatt aattgtgaga atgcgttttt 2229541 cgtcatgtag cactttcata acctccagat caatttctta acgtctgctt aatacactgt 2229601 ggccgttttg caaaaactgg cttcttgagc ggcgcatgcg ttcaatccgt tcctctgcta 2229661 agcggtcagc cgctaaatat gcaggaatgc cgtcacgctg agaaatctca agtacacgct 2229721 cgatattgcc gtaaatgcct tcaacttttt tcaatgcacg ttctgcatta tagccgtaaa 2229781 gctcatctgc cacgttgatg acaccgcccg cgttaatcac gtaatccggt gcataaacga 2229841 tgcccatttc gtgaatttga tcaccatggc gtgtctcttt taattggttg ttagccgcac 2229901 ctgcgatcac tttcgccttc agctgtttaa tggtgtcgtc gttaatagtc gcaccaaggg 2229961 cacacggcgc ataaatatcg cagtcttgtg aataaatgtc atcaggatct accgcacggg 2230021 cgccaaaatc ttcaactgca cgctgtacag attgtttgtt gatatccgta acgattaagt 2230081 ttgctccttc ttcatgcagg tggcggcaaa ggttataggc tacgttccca acaccctgta 2230141 cagcaatggt ttttccttca agagagtcgg ttccgaaagc agctttagct gctgccttca 2230201 ttcctctgta caccccgtac gctgtgactg gggacggatt tccagaagag ccgaaagcag 2230261 gagaaatccc tgtgacatag tctgtctcat catgaatgat atccatatcc tcgaccgttg 2230321 tgcccacatc ttcagccgtg atgtatctgc cattcagtcc ttgaatatag cggccaaacg 2230381 cgcggaacat ttcctcattt ttgtctttgc gcggatcgcc gataatgact gtttttccgc 2230441 cgccaaggtt taagcctgcc gccgcgttct tataggtcat gcctcttgcc aatctgagcg 2230501 catcttcaat tgccgcttct tcattttcat atgtccacat tctcgttccg ccaagcgccg 2230561 gaccaagcgt tgtatcatga atggcgataa tcgcttttaa tccagattgt tcatcctggc 2230621 agaataccaa ttgttcgtaa tcgtatttct ccatatattt aaaaagttcc atgttcgttc 2230681 ctcctaatgt gtgtattctt cagatgcgca tattgccagc gcaatggaat acagtttatt 2230741 ttcagcagag tccgctctgc ttgttaaagc aatcggtgct tttgctcctg taatgacagc 2230801 cgccacgctg gccttggcaa aataaatcag tgatttatat aaaatattgc cggcctcaat 2230861 tgttgggacg agaaggatat ctgcgttgcc cgctacgtct cccgaaattt ttttctgggc 2230921 cgcggcaatt tgtgaaactg cgttatccaa agcaagcggt ccatcaacaa tgcagccttt 2230981 gatctggccc cttttgtaca tttgagctag agcagctgca ttcacggtcg cttccatttt 2231041 agggttcacc gtttcgaccg ctgcaagggc agctgctttt ggcatattgt tccccactgc 2231101 atgggccaca tgaacggcat tttgcaaaat ctgccggagc tcttccagcg aaggagcaat 2231161 attcattgcc gaatctgtca caaacatcag ccggtcaaaa tccggtatat cgaagacagc 2231221 cacgtgagaa aggacacttg ctgaccgaag cccctcctgt ctgttcaata ccgctttaag 2231281 caaaacagaa gtcggcacat tgcctttcat taaaacgtcc gctgttttat gatgcacagc 2231341 acgaaccgct aatttcgccg attcctcagg agtattggca tggacgattt ccacttgatg 2231401 cccttgcatg gatgatgtca gctcgttcag ttttttgctg tcgcccgtta acaagaaacg 2231461 ggcggatagg tgctcggctg ccagctttac agcccggatc acttcctcat cctcagcatg 2231521 agcaaccgca atggtcttat ttttgtgtat cgacgctttg ccgattaaat ctttcagctt 2231581 catctgttac cacctttctt gtttcgactc cgccttttat tatgcaagtt ccatgccagc 2231641 tcttaagggt gctgtcatac caggtatacc gaaacattcg tgcagatgtt tgcgtttatt 2231701 ctgcaaatta ttgcatgcct tcatttgcaa ggccatattt atccattttg taatataaat 2231761 tccgaatgct gacaccgaga gcttttgctg tttttgtccg gttaaaatga tgcttttcaa 2231821 gcgtttgctg gatcaaatgc gcttcaaatt tttctactgc gacagacagc ttttcgcctt 2231881 caatatccgg aaaatcaaaa cctgttccct gatctgtgtc attttctttt tgctcaagtt 2231941 cgaatacagg caagtgatct ttttcaatcc attccatatg cggattcaga aaaatcatgg 2232001 ctcgtccaag gacattttca agctcccgga cattcccagg ccaatggtag gcagataagg 2232061 cgcgcaaggc ttgctgtgag agccctttta cattcctgcc gtaatcccgg ttgatctttt 2232121 ggataagtct gacgctcaat gcttcaatgt cctccaaccg ctgccgcaaa ggcgggatgg 2232181 agatcggata gcgattgatc cggtaataca ggtcttcccg gaatgttccg tccgccatcg 2232241 ccttttcaat atttacattt gtcgccgcga tcactctgac gttgacaggg atcgctttcg 2232301 tgccgcccac tctgacgatt tccttttctt gaaggacgcg tagcaatttg gcctgcatat 2232361 tttgtgtcag ctcaccgatt tcatctaaga aaatactgcc gttatttgct tcctcaaata 2232421 aacccttttt accgccgcgc ttcgctcctg aaaacgcacc atcctcatag ccgaacaatt 2232481 ctgattcgag caggttttca gaaagggctg cacaattcac gcgaataaat ttattgtatt 2232541 tccggtcact ttcgttatgg atggcatggg cgaacagttc ttttcctgtt cctgattccc 2232601 cgcgcagcaa gatggttgcc ggtgttttcg caccgagctt cgcctgctca agcgcaacca 2232661 gcatttgctc gcttttgccg ataatgtcgt caaacgtgta tttcgcttca agcgtgcgaa 2232721 taatttgtct ggcgcgatta agctccgctg tcagcatttt aatttcggaa acatcgtgaa 2232781 tcacgccgac gctgcctttc aaaatcccgt ccacaatcac cggtgctaca ttaacgatca 2232841 cttctttttc attcgggccg accttcattc tgacaccgcg gacaggacgt cttgtttcaa 2232901 gcacctttaa atgcatgctt tcgccttcgg aaatatcagt gtttgcaggc ttgccgatga 2232961 cttctttttc agaaagcccc gtcattttcg tatacgcttt attgattagc aggccgatgc 2233021 cgttttcatc aacgacagaa atcgcctcat cggaggattg aataattgcc tccagcatcg 2233081 tacggacctg ctttaagttg gtcacttcct ctgccagctc gaccgcatca gtgatatctt 2233141 taaacacaca aagagccccg agcagacgtc cgccttcatc aataatcggc agtcttgtgg 2233201 tcacaatttg caaatgatcg cctaacagct gcttctggtt gtattcaggc actcttgttt 2233261 ttaaaatccg cggcatctta gtgctcggaa tcacttcttt tattgggcgc ccaatgactt 2233321 cctcacgttt ttttccgacc attttttcgg ccatatggtt aaagagaatg atttcttcat 2233381 tgatatcaat aaaaatcatt ccatcatggg tggaattaaa aattctgtca tatttatagg 2233441 tttgctcttt tagcatttga atcaggtgct gcttttcttc catcagctga aaaacgatgt 2233501 atgccatttt tcccggcatg acaatggtat cttcatgctt tctttgaagg agctcgtcaa 2233561 acacggcttg atcgccggta gtatgaatga cgatatccgg tttttgttgt atgtaaggtt 2233621 tccaatcaga tgatacggca atcccatact gttctgcttc tttcaatccc ggcgcctcgg 2233681 ggtctttgtc aactacggca atgatatcta tgatggctgt tttaatcaga atatgtaata 2233741 acgccgttcc ccttttgccg gcacctacta tcagtacctt ttgcatcccg ataccccttt 2233801 gtatgaaaaa atttgcacac ctatttattc cgttgcaata atttgcacaa ccctatgtta 2233861 ccacgttttc ttctcttgac aaaatatttt ttccgctgga caataaagga aatgaaaaga 2233921 taaaggggtt ttctgaagat gagccgactt cttgcgcttt taatattagt catccccggg 2233981 gctatttctg ctttaggcat taaactgatg agagatacac ttttcggcca tacaatcaag 2234041 ccattttcag ctctttggct ccaagggttg tcaggattca tcttttttgc gatcggcctc 2234101 tatgtgctgg ccgggttcat tttatacaga gacagaaaac gcaatcaagt cagcccgcga 2234161 ttcagaaaac gatagctgaa aaaaagccgg agaatgctcc ggcttttttt gttgcattat 2234221 tcgtcaggca aaacggtctt ggcaatcgtt ttgtctaacg cttcatagtc ataataagaa 2234281 atcgtatcgt acagttcttt tcgtgtctgc atatcatgaa gtccttcttt ttgtgagccg 2234341 tgctccttca tcaaaccaaa catccgctca caagcttttg ccgccgctcg aagcgaggtg 2234401 acaggatata tcaccatgtg aaaccccata tcttcgaatt catcggcacg ataatatggc 2234461 gttttcccaa attcagtcat attcgcaagg agcggaacgg ggatacgctc agcaaactgg 2234521 cggaattcat tctccgcctg tagcgcttcc gggaaaattg cgtccgctcc cgcctcaatg 2234581 taagcctctg aacgttttat tgcggcatca agcccttcct gcgccctggc atcagtacgg 2234641 gcaacaacaa taagggaggg tgccgcttgt ttaatggctt ttattttttg cgccatttcc 2234701 tttatcggaa ctagctgttt gccatttaaa tgtccgcatt tttttgggag ctgctggtct 2234761 tccatttgaa cggctgctac cctggcttca agcatctccc gggctgttcg ggcggcattt 2234821 aagacaccgc caaatcccgt atcgatatcc acaagcaaag gcagatcagc tgcacgcaca 2234881 agatctttgg cccgttcagc tatctctgcc gatgtgatga tccctaaatc aggcagcccc 2234941 ctgctggctg tataggcagc accggacaaa taaatagcag aaaaaccggc ttctttcgca 2235001 agcaaagcgg ccatcccgtc atgggcgccg ggaatttgaa gaatgtccgg tgctgacatc 2235061 agcttgcgga aacgcccggc aagctcctct tgtgacgatt gcttattgac gatccacgac 2235121 atgaaacaaa atcccccttt tacatgcaga acatgtctac gaattcattt acgcgcatcg 2235181 tttgtaatgt ctcatagctg gtacagcgct cataaatgtg tttgtgctgt ttatcaggaa 2235241 aatgggtttt gagattgtca gaaaactttt ccagcagttt cggcactgct tcctctcttc 2235301 gaaaacgatg gccgagggga aactcacatt ccaccatttc cgtgctcgtt ccatctttaa 2235361 aatgaacctg aacggcattt gagatggagc gtttatcagg cttcaaataa tcctcggtat 2235421 atgttttatt ttcagtcact tccattttat cacgaagttt atctattctc ggatcattcg 2235481 ctgtttcagc ttcataatgc tgtgcggtga tatcaccaaa aagcaaaccg attgctgtaa 2235541 tgtattggag gcagtgatca cggtctgccg gattgtggag cgggcctttt ttatcaatga 2235601 ttcggatagc tgattcatgc gttctgatga caactcggtc aatctcgtca atccggttct 2235661 ttacctgcgg gtgaagaatg acggcggact ccgccgctgt ctgggcgtga aattccgcag 2235721 gataagacac tttaaataac acattttcca tgacataagc gtcgagcgga cgggcaagct 2235781 tgatctcttt cttattgaat aaaacgtctt ggaaccccca acccggtgca ctcaaggctg 2235841 tcggataacc catttcccct tttaacgaca tcagcgccaa atgaacacct ctgctcgttg 2235901 catctcctgc cgcccatgat ttacgcgagc ctgtattcgg tgaatggcgg tatgtcctca 2235961 atgctgcatt gtcaatccat gcattcgaaa gcgcattttt gatttcttct cttccgccgc 2236021 ccaaaagctt tgctgcaaca gcagttgtcg caactttgac aaacagcaca tggtcaaggc 2236081 caactcgatt taagctgttt tctaacgcca gcacaccttg gatctcgtgt gctttgatca 2236141 tcatctcaag tacgtcgcgt accgttaacg gctcttttcc ttcagacagc ctcactcttg 2236201 atacataatc agcagcggca aggattcctc ccaagttatc ggatggatgc ccccactccg 2236261 ccgccagcca cgtatcgttg taatcgagcc agcgaatcat gcagccaata ttaaacgctg 2236321 ccctcacagg atcgagaaca tatgacgttc ccggcacttt gcttccattc ggcacagtcg 2236381 ttcctggaac aatcgggcca agcagctttg tgcattccgg ataccgtagc gccaagattc 2236441 cgcagcccag ggtatccagc aatacatgcc ccgctgttgt atacgcttcg gcactagtaa 2236501 tctctttctc aagcacatag tctgtgattt cttcgataac acgatccgtt ttcggcattc 2236561 taccagctcc tttcatgatt ttgtttgata tcgcgggccc atgtaactga cacggggacg 2236621 gaagagccga ttattggcat gctgttcgat cacatgggcg cataaaccgg acgttctcgc 2236681 gctgaaaaag atcggcgtat ataaaggaat cggtatgccg agcatccaat acactggggc 2236741 agcatagtaa tccaaattcg ggtaaagccc tttttccttc tccatcagcc gctcacccgc 2236801 ttcgcacatc tcatataaac gatggtcacc ggctttatcg cataattgct gcagcgcctc 2236861 tttcatcatg agtgctctcg ggtccatttt tttcatatac acccggtggc cgaagcccat 2236921 gattttttct tttcttttca gttttgtttg caaaagctgc tcaaaatcag atgtcgtttt 2236981 tgcctccaaa agcaaataca tcacagcttc gtttgctcct ccgtgaagat tccctttcag 2237041 ggaagcgaca gccccagtca aagccccata aagatctgaa tgtgtagatg caatgaccct 2237101 ggccgcaaag gttgaattcg gcatctcatg ctcactgtac aggacgagcg accggtcaaa 2237161 aatctgttct tccaatgaag acggcaattt ccctgtcatc atgtagagaa aattcgcact 2237221 gtaggatagg gtttgaagcg gaagaatcgg ttctttctta ttaatgatcc tgtagctggc 2237281 agcagtgagg gcaggcattt tcccaagaag ctgataggcg cgttctttgt ttgcggaagg 2237341 agaccgatca tcaatttgcc gatcatagcc agcaagtgcc gacaggccgg tacgcagacc 2237401 atccattgga tgagtgtcct cagggagcag ctcaagcaga cggagatgat cagcaggcag 2237461 gcttgaggca ctgtttattt tacgttccag cgtttccatt tcactttctt ctggcagcct 2237521 gccctccagc aataaatgga caagctccag atagcttttt gtttcagaaa gttctattaa 2237581 atcatagcct cttatcaaaa tctggctgga ctgcgtgtca agataagaaa tatgagtttc 2237641 tgccgcaatc acaccgtcca accctggaga ataatgctgt ttctcctcca tatcctcaac 2237701 ctccgttttt gcgttttttg tctatcaggt tccgccaagc aaatacttgg aaataatcag 2237761 tctttgaatc tcgttcgtcc cttcataaat ttgcgtcacc tttgcatcgc gaagcaggcg 2237821 ctcaactgga taatccttca tatagccata tcccccataa atttgaacgg cgtctaacgc 2237881 cgcctttacg gctgcatcgg aagcaaattg tttagccata gacgcttctt ttccacagtt 2237941 taggccgcgg ttatgaaggt ctgcagcgtg gtagacaaga tgtcttgccg cctcagctct 2238001 agtcgccata tcagccagct taaatgatat gccttgattg gctgcaatcg gccttccaaa 2238061 ttgcactcgc tgcttcgcat aatcaacggc atgctcaaga gccgcctctg caattccgag 2238121 ggcctgtgcc gcaatgccga tccggccgac atttaaattc gccatggcaa tgtgaaagcc 2238181 atccccctct ttgccaagca aattggcttc aggcacttct gcattatcaa aaatcagttc 2238241 cgtagtattg gagccataaa gccccagctt tctttctttt tttccaacgg taaaaccggg 2238301 tgtgtttttt tcaacaataa aagccgaaat cccgtgcctg ccttgatctg gagctgttaa 2238361 agcaaatgtg atatagatat cagctgctcc gccattcgtt atgaatattt tcgatccgtt 2238421 taataggtat ttgccgttct ttttgattgc tgttgtgcgg aggctcccgg catccgaccc 2238481 cgagtgaggc tccgttagtg caaatgcgcc caaatggtct cctgacgcga gatttggtat 2238541 atatttcatc ttctgttctt cgttgccgaa atacagaatc ggattcgtgc cgactgaggt 2238601 atgaacggag agaatcacgc cgacagccgc gctgattcta gaaatctcat gaattgccaa 2238661 aatataagaa acaacgtccg ctccagcacc gccgtattgt tccggcaccg gtattcccat 2238721 cagtccgtgt ttacccattt ttttgatcag ctgaaaggga aattcgtccg ttttctccat 2238781 gatttccgca gcgggagcaa tttcttttcg tgcaaaatca cgcaccattt ttcgcatcat 2238841 gacttgctct tgggttacat gcaactcggc cacccccgga tggaatagac ttcaggaagt 2238901 cttctcctca tagtcataaa aaccgcgtcc gctctttttg ccaagccagc ctgctttgac 2238961 atacttgcgg agcagcgggc aaggacggta tttggaatcg ccaaggcctg agtgaaggac 2239021 ttccataatt gataaacacg tatccagtcc gataaaatcc gctaatgcaa gcggacccat 2239081 cggatgattc atgcccagct tcatcacttc atctattgcc tccggcttcg ccactccctc 2239141 atacacgcaa tagatggctt cattaatcat tggaagaagc acacggttgg aaacaaaccc 2239201 aggaaaatca ttgacttcta ccgctgtttt ccccatcttt tccgctaatg ccataacatc 2239261 taaggccgtt tcttctgatg tagccaagcc tcgaatcact tctaccagct tcattacagg 2239321 gacgggattc ataaaatgca tgccaataac ccgttgaggc cggtttgtta cagcagcgat 2239381 ttctgtaata ggcaaggaag atgtattgct ggccaaaatc gtatgaggcg ggcaaatgcg 2239441 atcaagtgtt ttaaacatct cagtttttgc cgccatgttt tctgcgatag cctcaatcac 2239501 aatgtccgca tgctctgcct cctcaagtgt ttgagaaatc gaaatgcggt tgattacgct 2239561 cttcacttcc gtctcggtcc tttttccttt ctcagcatca cgggccagct gtttcttcag 2239621 ccgtttcaat cctgcctccg cggcctctgg attcacatca tacatccgca cataaaagcc 2239681 cgcgtcggcg gctgtttgag caattccgct ccccatctga cctgcgccag ctaccatgat 2239741 ttgtttgatt tccattcaaa tccccttttt catcatgttt taatgaacct gcactaagac 2239801 ggcgtctccc tgtgctgccc cgctgcaaat agcggcaacg cccagacccc ctccccgtcg 2239861 ctttaattca taaacaagcg tcatgagaat tctcgcaccg ctcgcgccga tcgggtggcc 2239921 gagcgcgatc gcaccgccat tcacatttac tttttcaaga tcgaaaccta cgattttttc 2239981 acatgtcaaa acaactgaag caaaagcttc atttacttca aacaagtcaa tatcttggac 2240041 agttaaacca ttctttttca ggagcttgtt aatagcaaac cctggcgctg ccgccagctc 2240101 gtgcgctggc attcccgtag ttgaaaaacc aagaattgta gccagaggcc gtttgccaag 2240161 ctcagcagct ttttcctcag acatcagcac gaacgcgccg gctccgtcat tgactccagg 2240221 agcattgccg gctgtgatag aaccgtcact tgcataaatc ggagcaagtt ttgcgagctg 2240281 atccagactt gtgtcacggc gaatcgcttc atctttatca acaacgtttg gttttccttt 2240341 tcgaccgatc cagttgacgg gaacaatttc atcctgaaac ttcccttcat cggcggcctt 2240401 agctgccctt gcatgacttc tcaacgccca ttcgtcctgc tctcttcgtg agattgcata 2240461 ttccttggca gctgtatttc cgtgaacagc catgtgcacc tcgtcaaatg cgcacgttaa 2240521 tccgtcatac accattaagt ccctaagctc gccgtccccc atccgtgctc cccagcgccc 2240581 ggcgggaacg gcatacggaa tattgctcat gctttccatc ccccccgcaa caagtatgtc 2240641 cgcatcctgc gcccgaatca tttgatcaca taaagtgaca gcgcgaaggc cggaagcaca 2240701 gactttattc agtgtttctg acggcacact ccaaggcatt cccgccagac gggcagcttg 2240761 acgggaaggt atctgccctg agccggcctg gacaaccatg cccatgacgt ttccttctac 2240821 atcatctcca gagactccag cctgttgcag cgcctccttc atcacaatgc ccccaagctc 2240881 agcagctttc acctctttca aaactccgcc gaatttgcca aatggagttc ttgcagcact 2240941 tacaatgact gttttcctca tggtttcacc tcattcagaa gatagacagc gcttacaatt 2241001 tctagttgtc ttctatgaat gtatgctttg aaacgggcat gaatgaatga aaaaagaagg 2241061 ctgcgtcaaa cagcctcctt ctaacaacta ttcatttttc agcaatgccg aagccttttc 2241121 tggaaagtcg gtaaacatgc cgtctgctcc cgcttcaatg agacgcttca tatcttccgg 2241181 acgattgact gtatacggcc ttaccttaat caaaccgttc ctcattttct tcagtacttc 2241241 atctgtgacc cctgggctgt ttatcttcgg gtgatagccg gaagccggaa tagacgcgat 2241301 atatcgatct gcctgataaa gcacatctga agttaatact gcccgttcga tatgcggtgc 2241361 aagccgggcg cacagcgcca agctgtcatg attaaacgtg gataggatga ctctgtcctc 2241421 tacattaaat cgcttcactg cctccagcac tttttcttcc attccctcat agcggatcac 2241481 gctgtttttt aattcaatgt tgatgagaaa atcctttttt accgcccacg agagcacatc 2241541 ttctagcagc ggcactttta tatcgctgta cgcttgatcg tgaccagcgg ccgcattcgc 2241601 agtctttacc tcatcatagg ctgtatcctt cacgaatcct ttaagtgatg tcgtgcgatt 2241661 aagtctttca tcatgaatta caacaatgcg tccgtctttc gtcagctgta catcaagctc 2241721 tatcccatcc gctccggctt caattccttt ttcaaatgca agcattgtat tttcgggaaa 2241781 ttgacctgat gccccccggt gggcaaaaat ctttgtcatc gtttcacctc aaaccctaaa 2241841 gttttctcca ttatacttat tttgtcggct ccactctagg attaaggctg tatcaatcta 2241901 ctgatcataa taagaatcaa tgccattgac aatcgcatct gcggcctttt gctggtattc 2241961 ttcacttccc agcttgtccg cgtcagagct gttcgtgata aacccaagct ccgccaacac 2242021 acttggcatt tgtgaatatg taatgacgta aaagtctgat tctttcacgc ccctgtctct 2242081 cgtttgtaag gaagaaacga gctgtgactg aatatcggat gccagacgcc ggctgttctc 2242141 cccttcataa tcagattgaa aatacgtttc tgttcctgaa gctgaagcaa cccctgaatt 2242201 cacatgaatg ctgacaaaaa ggtcagcctg attggcactt gccttagcca ctctttcctc 2242261 caaggtcaga aaatgatcgt cagaccggga tgcaacagga ttggctccct cctcttttag 2242321 tttgtctgtc acatgctctg agacagccaa attaatatcc ttttcaaaga gcccgtttcc 2242381 gaccgctcca ctgtcttcac cgccgtgtcc ggcatcaata tacactgttt tcccttctat 2242441 cggctctgct gcctgtgcac aaggcgcgag cgtcaaagcc aatccgcaca gcgccaagct 2242501 cctccataac attctcaact tactccctcc ggtcacgagt tctttcgcag ctgaatatct 2242561 tccagctgta aagttccatt atccttcttt gtatatttca ccaggacatg tgtctgatct 2242621 ggcagtgatt cacattcatc acgtttatcc ttcggaactt gtatcatggt ttcttctcca 2242681 ttaagagaaa ccgcaatcgt atgaggatca gccgagccaa tgtattttcc ctcttcggta 2242741 aacctcggca ctgagtcatc cgcacttgca acactgcacc ccgaaagaaa gagcgcagta 2242801 aacagcaaaa gaaccgtttg tttcacatga ccacctcttc ctgatgtttg gcttttatct 2242861 ttgaccagaa tggagaattt gtaaagacaa cgcgaatgca ggcgagcaag ttccatgatt 2242921 ttcaaaaggg ctatacgacc cgatcatttc ctgttgttag aaagataacg agcagatttg 2242981 tctatgagga tggctctaat tgaggcgcca attagaaaaa attagcggaa agaagcaact 2243041 ttttattcat tttaaaaaat ttgagaatag ggtgagcaaa tcgtttgacg ggtgggtcag 2243101 ccaagcgtaa ccttttaaag gatatttact ttattgaaag aagttaaagc catgaaaaaa 2243161 ttcgttctgc tgctggcggc agctgtcatc acatgctcca tcggccacca aatcagtggc 2243221 ggctacaaag gccccgaaaa agagcggcca aaacatcact ctgcactcaa gatattcagt 2243281 cggtaaagca gatcaattgc attaattttt acatataggc tagaatatgt gcgaatccaa 2243341 acgaaagaag atgatcaaat gaatcctaag tataagccac tttttgaacc atttacgttt 2243401 aaaagcggcg ttacaatcaa caaccggatc gcagtagcac cgatgactca ttacgcttct 2243461 aatgaagacg gtacaatatc tgaagcggag ctcgactaca tcatcccccg ttcaaaagag 2243521 atgggaatgg tgattacagc ctgcgcaaat gttacaccgg acggaaaagc attccccggg 2243581 cagccggcca tccatgacga ttccaacatt ccaggtttaa aaaagttagc acaagccatt 2243641 caggcacaag gcgctaaagc tgttgtacaa attcatcacg gcggtattga gtgcccgtct 2243701 gagctcgttc ctcaacagga tgttgtgggg ccaagtgacg tgtttgataa cggcaaacaa 2243761 attgctcgcg cattaacaga agaagaagtg gaaaacattg tgaaggcgtt tggagaagcg 2243821 acaagacgcg ccattgaagc cggctttgac ggtgtcgaaa ttcacggtgc aaacggctac 2243881 ttaattcagc agttttattc tccgaaaacc aaccagcgca cggatcgctg gggaggaagc 2243941 gatgaaaaac gattagcctt cccgctcgct attgtcgatg aagtgaaaaa agccgcttca 2244001 gaacatgcga agggtgcatt cttagtcggc taccgcctgt ctccggaaga acctgagaca 2244061 ccgggattga caatgactga aacttatacg cttgttgatg ctttagggga taaagaattg 2244121 gattatcttc atatctcact gatggacgtg aactcaaaag cgcgccgcgg tgcagatccg 2244181 actcgcacac gcatggactt attgaatgaa cgtgtcggaa acaaagtgcc gctgatcgcc 2244241 gtcggttcca tccattccgc tgatgacgcg cttgccgtca tcgaaaacgg tattccactg 2244301 gtcgctatgg gacgcgaaat tctagttgac cctaactgga cggtaaaagt aaaagaaggc 2244361 cgtgaaaagc aaatcgaaac agtgatcaaa ggcacagata aagaaaaata tcatttgcct 2244421 gaaccgctat ggcaagcaat tgtgaacaca caaggctggg tgccttataa agattaatgt 2244481 gcaaagactg ccgaaacgat tcggcagtct tttttccctt tatataaata gtttgtgtac 2244541 acatctaaac agcaaaagaa agagctcccc accaacttcg aaaagaaaat ccaggaaaaa 2244601 cccctcacgc tttcttgctt ttttcttttt cattcgtacg tctccttttt acatgaatac 2244661 gccttactta cgattttgca ggagaaaggt ttcattttat aacggacaca tctagggtcg 2244721 atcatgcttc gtgatcctat aagatgtatg aatggaccaa gagtgcaggt aataccgcca 2244781 tttgctttcc ttacttttca aacctatcct ttactatatg cggatactta atattcttct 2244841 cccatactac aaatgtcccc aaaacaaaac gcctcctatt tatcagcgca aactaataaa 2244901 taaaagacgt ttgatttaat gaccacttaa taagctcatg tttaagaagc cttatgctct 2244961 aacctcagct tatccgcaac cattgcaatg aattcactgt tggtaggttt agcttttgtc 2245021 atgctgacag tataaccaaa caacgaggaa atggaatcaa tgtttcctct gctccatgcc 2245081 acttcaattg catggcggat cgctctttct acacggcttg cggttgtgtt aaattttttg 2245141 gcgatgtccg gatagaggac ttttgtaatg ctgccgagca attcgatgtc attgtatacc 2245201 attgagattg cttcgcgcag atagagatag cctttaatat gggctgggac gccgatttca 2245261 tggataatgc ttgtgatgct cgcgtcgaga tttttcttct ttggttcagg ctggctgctg 2245321 cgtataatac tgctttgcga tgatggcgca cgatgcgtca cactgctggc atttccgctg 2245381 acctggcgga tatggccgac aaggttttcc atatcaaacg gtttgagaat aaagtaggac 2245441 gcgcctaaat cgacggcctt tttcgtgaca tcttcctgcc caaaggctgt cagcataatg 2245501 acattcggct gttttttcag atctgattcc ctcagcctct ctaaaaccgc aagtccgtct 2245561 agatgcggca taataatatc taatacgagc acatcgggat ctttttcttt aaacagcgac 2245621 aggcattcct gtccgttata agcaacgccg atcacttcca tgtcttcctg tccttctata 2245681 tattcactta acaggcttac cagctctcga ttatcatcag caacacaaac tttaattttc 2245741 tccacgtttc ttcctcccca aatgtagtta acaggattca cccttgctac atgtttacat 2245801 tcgacaaaac cgctatatac cctctaaaaa aatcataatc accaatatta gtggcatatc 2245861 tttgttattc tatgtttttc tctgtttttc gactaaaaat gaaatttgac aaacaaggaa 2245921 acgtgaattt gtcgaaaaat cttcttttgt atattttacc gtatgtattc tgagaagtga 2245981 agagggatca aaataaaaaa actgccggaa actccggcag tcagcttgct ttttcttttc 2246041 cataaatatc gattcctgct tctgacagca tccattcaat atgaacaccg tagccgcttg 2246101 tcgggtcatt tacaaataca tgggtgacag caccgatcac ttttccattt tgaatgatcg 2246161 ggcttccgct catcccctgt acgatgcctc ctgtttcttt caacagtctt ggatcggtaa 2246221 ttttcaacac cattcctttt gtcgcaggga atttttgcgg cgttgtgctg acgatttcaa 2246281 tatcgaattt ttctactttg tcatcatcaa taaccgttaa aatttcagcc ggcccttttt 2246341 tgacttcggt agaaaacgca accggcaatg cttgatctga tatgttgttt tgaatcggct 2246401 gatgcagtgt gccgaaaatc ccaaacgggc tgtttctgtt aatatccccg atcgttttgc 2246461 gttctgagga aaatcgcgcc agtttttctc ccggattacc gcctgtccct ttttcaattg 2246521 atgttacagt ggatttaacg atttctccat tctccactac aattggtttc tttgtgtcca 2246581 tatcggaaat cacgtggcca agtgctccgt atttttttgt tttcggttca taaaaggtca 2246641 tagtgccgat gccagcagca gaatctctga tatataaccc gattctgtat ttgccttctc 2246701 cttcatcctt ttctgggatc agcttcgttt tgattttctg tttatcacgt ttgatcagta 2246761 agtctaaaga ttcaccagtt ttcccagcct tttgaataaa tggggctaca tcattcattt 2246821 tttcaatttt ctgtccattc atctcaataa tgatgtcgcc cgcttcaatt cctgccgttt 2246881 ctcccggaga ttttttgcct tcacttgtat tgatttgatg aaatccgacg acaagaacac 2246941 cgacggaatg aagttttaca ccgattgatt gtccgccagg tataactttt aaatcaggaa 2247001 gaacatgcac ttttgttttt ttaattggaa atccggcaag atcatatacc aattctgact 2247061 cacctgattt tttgcccgtc accttgattt catgcggatc tttctttact gtaaacgctt 2247121 ctgaggattc tgatgtctga gcgtttaccg ataaactcgt ttcaatcgct tgtgtttggg 2247181 tttcaaatac tctcatttgc gttggaatca gtaaatattc ttttagcggt ttgcataaac 2247241 ctacacttaa taacgaaaca aggagaatta aacctactgc ttttctgatg ttatcgggca 2247301 ttcactactt cactctcctc gctcctatcc cacaccttct ttatgacttg ctgctacatc 2247361 atttaatttt gccttctgac ggcttattta taactgtcat atgaagaaaa acattggata 2247421 tactgatgaa cgaatggatg tgcacgaaaa aaataagctg cgcttctcgc gcagcttacc 2247481 cagttgtttt gacttgatcc gcttgtttta aaagttcttt cgcatggcgt ttcgttaagt 2247541 cggttacttc gacacctgca atcatgcgcc cgatttccgc taccttttcc tgcttagaga 2247601 gcggcttgac acgtgtcgtc gttctgccgt cttttaactc cttcgcaata taaagatgcg 2247661 tatcggccat ggcagccacc tgaggcaggt gtgtaatgca cagcacttgt gatcctattg 2247721 acaccttatg gatcttctca gcaattgcct gtgcgaccct gccgcttaca ccggtatcaa 2247781 cctcgtcaaa aatgatcgat gtcacatcct gttgtgagga aaaaatgctt tttatggcaa 2247841 gcatcacccg tgacagctct ccacctgaag cgactttcga aagggatttc agcggctcgc 2247901 ctgtattggt tgaaattaaa aacttcacca ggtcaatccc ttgttcagtc agctgaacgg 2247961 gctggccgtt tacaagcggc gcctcttcat tgcgtgacgc tgttctgacc ttaaattccg 2248021 tatcaaaagt tgatttttcc atgtacaggc tttttaattc ccgatgaatc tcatcagcca 2248081 gctttttcgc ccatgttttt cggatttgtg acacatttgc cgcttccact gcgacatctt 2248141 tgccgacgga gtcaagctcc tttttcaagc tttgaaggtg gctgtccctg ttttcaattt 2248201 ggtcaatctc ttcttcaatt ttagaagcat attccaaaat gtcttcaaca gtggcaccgt 2248261 attttcgttt cagctgtttg atttcattaa gtcgcgtctc aatatagttc aggcgttccg 2248321 gatcaaattc aagctcatcc agcatatttc tcatctgaaa tgtggcatcc tcaagcaaat 2248381 agtaggagtt cgaaacactt tcagacattt ttttcagcgg ttcgtttata tcagatatat 2248441 cttcaagctg cgctgatgcc attccaaccc agtccaatcc gccctgctca ctgcgaagcg 2248501 cgttatatgc attttgcagc gactcatata tcttctcaaa gtttgaaatt tgctggcgct 2248561 cttcttggag ctgttcatct tcgttaagct caagctttgc cgattcgatt tcttcgagct 2248621 gaaattgaat aagatcaaga cgatgggcca tttcctgttc gctttcagaa agctgcttaa 2248681 gctttttgag cagcttcaca taccgctggt acccttcctg atacgttttg agcgcgcttt 2248741 ccacttcggc cccggcaaac ttgtccaaaa gctggagatg attttcgtct tccattaaca 2248801 gctggttatc gtgctgcccg tgaatatcta ataaaagcct gccgatctct cttagtgaag 2248861 caatcgtgac aagcttgcca ttgacacggc aaacgctttt cccgctcgtg ctgatatccc 2248921 ttctcatgac gatcatttcg tctgaaacgt cgattccctg ctcagcgcat acgcctaaaa 2248981 caggatggcc gctctccaac agaaacagcc cttcaagttc ggcttttgct tccccatatc 2249041 taacaaattc agatgatccg cggcctccga ctaaaagaga aatggcatct atgatgatgg 2249101 atttgccggc tccggtttct cctgttaaaa ccgtaagccc gcgttcaaaa gaaaccgtca 2249161 gttcctcaat aatggcaaag tttttaatcg atagttcagc taacaaacag cattacacct 2249221 cttatctttg ttagattttc tgttacagca gttcaaggag cctgtttttt acgccttctg 2249281 tatcttcagg agtccggcaa ataattaaaa tcgtatcatc tccgcaaatg gtccccatca 2249341 tttcatccca gtccaaattg tccatcagcg ccccgattgc ctgggcattg cccggcatcg 2249401 ttttcagcac aatcatatgg cttgctgagt ctattttcac aaatgcgtcc atcaatgccc 2249461 gctttagctt tgacagcgga ttgaaacgct ggtccgccgg aagactgtat ttgtaagaac 2249521 cattatttgt aggcactttt acaaggtgaa gttctttaat atcccgtgat accgtggcct 2249581 gcgttacttt gtatccatcc tgctttagca tgtcgaccaa ttcatcctgc gtttcgattt 2249641 cattgcttgt aatgatctct ctgattttaa tatgcctctg gcctttgttc atgtaagcac 2249701 ctctatttcc aagcttatct gttcttttat gttatatgat tctctgcaca ttgtacatga 2249761 atgcagaaaa aaggaataat agcgccctat tattccggta catctgcttt tttttctttt 2249821 aacgtcttat gtgcttcttc tacaacgcgc atgatctctt cttccggcag ttcctggcct 2249881 tcctgtccct ctcccggcca atgcaaatga aggagaaact caatatttcc gtctcctccc 2249941 gtgattggag aaaatgacaa gcctttacag atatagcctt cagcggcaga aaaactgatc 2250001 attcgcttga gcacatcagc atgcacttta ggatctctaa caatcccttt tttgccgacg 2250061 gattcccgtc ccgcttcaaa ctgaggctta actaaagcca tgcagtcgct gcccggtacg 2250121 agcaaagtcc ttaggacagg caggatgagc cgcagtgaaa taaaggacac atcaattgtg 2250181 gcaaactccg gcatgccctt tgtaaagtct gccggtgttg cataacgaaa gttcgtccgt 2250241 tccatcacga cgacccgttc atcctgtcta agcttccatg caagctgatt atagcctaca 2250301 tccacagcgt atgactgttt agctccattt tgcaaagcgc agtccgtaaa accgccggtg 2250361 gaggagccaa tatcaatcat aattttatct ttgacagaga cgggaaattc cttcaacgct 2250421 ttttcgagct ttaagccgcc cctgctcaca tacctcagcg ggtttccttt gacagttaac 2250481 ggaaggtcgc ggtcaatttt ttctccaggc ttgtccaagc ggttttcgtt tgaatagacg 2250541 atccccgcca taatggctct tttggctttt tcacgcgttt ccgccagccc tctttccact 2250601 aataatacat ctaatcgttc tttctttgac gtcatgatcc aattcctttg tgtgtctttg 2250661 gtggcatcag taatctaata cgatttgcca cctgctgttt tgtcagtcca atttcctcaa 2250721 gaagcgctgt tacacttccg tgttcaataa accgatcagg tatacccatt ctgtcaatcg 2250781 gagtatgata ttcaccttga tcatgagcga attctaaaat cgagcttccg aaaccgcctt 2250841 ctaagaccgc ttcttcaatt gttaaaattg gcaagccttc ttttaggata ctcttcatca 2250901 tcttttcatc aatcggctta ataaaacgcg cattcacaac gcgcacggaa aggccttctt 2250961 tctgcagctc ttcggctgct tcaatcgcca tttcgattgt tgtgccgaat gttaagatga 2251021 cagcatcgtt ccctggacgc agcacctccc acgtaccgat cggaatcgtt ttcaactgtt 2251081 catccatttt tacgccgagt ccgtttccgc gcggaaaacg cattgctatc gggccttcgt 2251141 catagctaag tgctgtatga accatgtgct ggccttcatt ttcgtctttc ggcatcatta 2251201 agaccatgtt tggaatgtgg cgcataaacg caatatcaaa cacgccttga tgtgtctctc 2251261 catcagcgcc aacgagtcca gcacggtcaa ttccaataaa cacattagcg ttttggcggc 2251321 agatgtcatg aacaacttgg tcatatgccc tttgcaggaa ggttgagtaa atcgccaaaa 2251381 acggcttcat accctgcatt gccatagctg cagccattgt tgcggcatgc tgttctgcga 2251441 ttcctacgtc gaacatccgg tcagggaatt cctttgcgaa gccttcaagc tttgaaccga 2251501 caggcatagc cggcgtaatg gctacaatgc gtccgtcctc gcgcgccatt cgctgcacag 2251561 ttccgctgac aagaccgctc cacgaaggag ctgcggcttt cggctttaca aagtcaccgg 2251621 tattaatttt atatggtccg gtaccatgcc atgtcccaat cgtatcggtc tcagccggtt 2251681 tgtacccctt cccttttttc gtaatgacgt gcagaagaac agggcctttc gtttttttgg 2251741 cgtattgaag attctcaatc agctcatgat aagaatgtcc gtccactggg cccaaatacg 2251801 taaaaccgag ctcctcgaaa aacattccgg agacgagcat gtatttcagg ctgtctttga 2251861 cccgttccgc cgtggcggca agcttgcccc caactgccgg aatcttttta aataagtatt 2251921 caagctcatc tttgacccac tggtatttcc ccgcagtgcg gagccgtccg agcatagagt 2251981 gaatggcacc gacgtttggc gcaatactca tttcattatc attaaggatg acaatcatgt 2252041 cttttttctc gtcgccgatg tggttaaggg cttcgagcgc cataccgccg gtcagcgcgc 2252101 cgtcaccaat gatcggaata atatattcat ccgttccttt aatatcacgg gcagctgcca 2252161 ttcccatcgc gcctgacaga gaagtcgagc tgtgcccggt ttcccaaaca tcgtgctcgc 2252221 tttcactccg ctttggaaat ccgcaaagcc ctttgtactg gcgaagcgtc gcaaattctt 2252281 ttccgcgtcc tgtcagcagc ttatggacat acgactgatg gcctacatcc cataaaaatt 2252341 tgtctttcgg gctgttaaat tccttatgca gggcaacagt aagctctacg acacctaagt 2252401 ttgggccgat gtggccgccg gaagcggata aacttgtaat taaaaactga cggatttcat 2252461 cacttaattt ctctaattca tcaatggaca tgttttttaa aaacgacggg tcctgtattg 2252521 ataaaagatc caaagcggat caactcactt tcagcatgaa tttctgcaat gatacatgtc 2252581 ttttgcatgc cgagctgaca ataatctcag acataaaaaa agacaaacgc gcttttcctt 2252641 ttcatttttc atataaactg cttacatttt accatacctc gtgcagccgc ttcaaattag 2252701 gatcgtttta gtgatctctt gccgcaatta aatcacaaag ctcatataaa aggtcttttt 2252761 gaagagagag tccgccgatc aatcgcttcg cctcttttat atgaacatcc aatttatgtt 2252821 tggccccttc caatgaaaga agcgacgggt atgtcgattt gtcatttgtg gtatccgagc 2252881 cgacacgttt gccgattttc tcttcactgc cttctaaatc taaaatatcg tctctgattt 2252941 gaaatccgat tccaatgtgg ctgctgaagg tacgcagtgt ttcaatgtct tcctcaggcg 2253001 catcagccaa aatagcaccg gcgattacac aaaagccaag gagcttggca gttttccgtt 2253061 catgaatgga ttcgagctct tcaagcgtga cttgtcggtt ttccgcttcc atatcagcta 2253121 cttgcccacc gaccatgcct tcggtgcctg ccgctgaaat cagttcattc acaagccgca 2253181 ggcgcttttc tgctgacacc tcgtctgaca cgtgggaggt aatcagctta aagctttctg 2253241 tgagcagccc gtcacccgct aatactgccg tcgcttcacc aaacacttta tggtttgtcg 2253301 gcttcccgcg gcgcaaatcg tcatcatcca tgcatggaag atcatcatga attaacgaat 2253361 acgtgtgaat catttcgaca gcacagccca ccggaatgcc gtctttttcg ctttttccat 2253421 atgcatttaa aacagccagt acaatcagag gccgcaaccg ctttccgccg gcctgtagag 2253481 aatatagcat agatttcttt aatgagtccg gcatatcaag cttttctgta tagacagaaa 2253541 gctgattttc aattgttttt ttccggtccg ccagaaagct cgttaattta tttgtcacct 2253601 tcgtcttcct cctgaacact gaaaggtgcc agttcgccgt cttcttttaa aatgaagtcc 2253661 atttgctttt cgactttttg cagcttttca tggcacattt ttgacagagc catgccttct 2253721 tggaaatagt taatggcttg ctctagaggc acatctccct cttcaagctt tgatacaatg 2253781 ctctcaagcc ctttcatcgc ttcttcaaat gtcatgtttt catttttttt cacgtctgtc 2253841 atttttcttc ccctctcttt tctaatactt cacaggtcag cacgccatcc ttcagcttga 2253901 tttcaagccg gtcctgctct tctatttgac tgacactttt aatgagttta tcttctttat 2253961 aagccaagct gtatcctctt tccatcactt gaagaggact tagtgcattc agcttgccaa 2254021 gaacggtttg aaattgggaa tgcagctgct tcatttggat attcatattt tttctcagct 2254081 gatttgtttg ttcctggtat cgtgttctcg cttgtttcag ctgttcatga ggatgcaatg 2254141 cctctaatct gtacgtttca cgctccagct gtctgctttt ccgatctaaa agagcggtca 2254201 gctgtgcttg aaactgctgg tacgcgaggt caaactgctg ctctttttgc gcatacaaac 2254261 gctttggaaa acgaaaggca taggacgatt gcagcgtttg tatccgttct tttttctggc 2254321 cgagatgctg ctgcattgct cttgtcattc tgacttccgc tgtttttgtc cgttcgatta 2254381 aatcagtggt atgaggcaca gcaatctcag ctgctcctgt cggcgtcgca gctctgatat 2254441 cggcgacaaa atcactaatc gtaaaatccg tctcatgtcc gactgccgat ataatcggaa 2254501 tattggaagc aaagatggcg cgtgctacaa tttcttcatt gaatgcccac agttcttcta 2254561 tcgaaccgcc gcctctcccg acaattaata cgtcgcaaat ctctttttca tttgcctctt 2254621 caatgcgcgt aacgatggat ctgctcgcat tttcaccttg tacgagcgct ggaagaacaa 2254681 tgacttttac aaggggatat cttcttttta gagttgtaat aacgtctctg acagcggcac 2254741 ccgttggaga tgtcacaacc ccgattgtgg ctggaaatgc ggggatttgt tttttgtagc 2254801 ggtcgtcaaa taaaccttct ccggcaagct tcttttttaa ttcttcgtac gctaaataaa 2254861 gcgctccaac cccgtcaggc tgcatttctt tggcatataa ttgatagttt ccgctcggtt 2254921 catatacgga aattccgcct ctgaccagca ctttcattcc gttttcaggt ttaaaaggca 2254981 gacgctcgct ttgtctcgcg aacatcaccg actgcattct tgcgttttcg tcttttaaag 2255041 tgaaataaat atgccctcgt gtgtgtatct ttacattcga caattcgcct ttaatccaaa 2255101 tattttcaag gtgaggatct acatcgaatt ttcgttttat atactttgtc agcgctgaga 2255161 cggtcacata cgctgcttca cccatgtcta aaaactcctc tcctaagcat tcctgcacca 2255221 taactaaaga aaacccgccc tggctttagg agcctgaaga agcgggtatc gtgctcatat 2255281 tcaaggcggg taaacatttc gcctgtgaat atctccaatt atctatgata acgtacgttt 2255341 cgcagattta acagtattat gcgcaagcat cgtgatggtc atcggaccta ctccgcccgg 2255401 aaccggcgtt atgaaggacg ctttttcctt tgccccttca aattcaacgt ctccgcaaag 2255461 ctttccgttt tccagacggt taacgccgac gtcaatgaca acagcgccct ctttgatctg 2255521 gtctgcactg atgaagttgg ctctgccgac tgccaccacc aggatgtccg cttttttcgt 2255581 atgttcagta atattttctg ttcttgaatg acagtaagta accgtcgcgt tttcatttaa 2255641 taaaagctgg ccgacaggtt tgccgacaat gttgcttcgg ccgactacaa caacctcttt 2255701 accggaaagg tcaatattgg ttttcttcaa aagctcaaca attccatgag gcgtgcaagg 2255761 aagaaacgta tcttcgccaa gcagcatttt ccctacgttt aacggatgaa aaccgtctac 2255821 atctttatca ggggagatac gttcgatcac cgctttttca gaaatatggt ctgggagcgg 2255881 aagctgaacg agaatgccat gaaactcagg gtcttggtta tattgatcaa taatggaaag 2255941 cagttcagct tctgtgaggc tgctgtcaaa ttgatcgagc ttgaaattca ttcccattgt 2256001 ttctgccgct tttttctttc ctcgcacgta agagtgagaa gcaggatcat ctccaatcaa 2256061 aataaccgcc agtccgggag tgacgccttg ctttttaagc tcttctacct cttttgccaa 2256121 ttgttcgcgt ttttctctag ccgtttcttt tccgtcgatg attgttgcag tcattttctt 2256181 tcctcctatg attgttcaat atcagattta atgttagaaa gaaccccgtt tacaaacttt 2256241 gtcgctttgt catcaccaaa ccgttttgcc agctcaatcg cttcgttcat ggagacattc 2256301 accggaatgt cttcggcata tgccatttca tatgctgcca ggcgcaaaat cgcacggtca 2256361 acattggcaa tccgatcgag cttccaattc accagatgct tggagatcat ttcatccagc 2256421 tggtcttggt gttccaatac cccgtgtaca agctgttcaa agaaaggatc tgttttttct 2256481 tcatccagtg cgtgttctat ggcttcattc actgcaatat cgctgacatc aatttgaaat 2256541 agtgcctgca aagctttttc tcttgctgtt cttcttttca ttttctttct cctttgatcc 2256601 tctttatccg cttgtcgtta agccacaaag agatcataac atattttttt cgtatccgca 2256661 tattgaaatc aaggtttttt taccctatta ccgaatattt tcacacacct taatatgatt 2256721 attcggattt cacgttcatg aagaaactcg gctatgtaag ccggctttct tcatgctttg 2256781 aaataaaggg taacgtgtaa aaaaaccaaa gggccgccct ccccttggtt tcgtgttaag 2256841 ccatttacat ttcttcgtcg atttggactt cttgggcttt tgtgtcaaat tgaatgccga 2256901 cgatgtgaat attgatctcg ttaatcgaaa gagacgtcat atttaataag gtttgacgaa 2256961 tgttttcctg aacggatgct gcaactttcg gaatcgaaac gccaaatgta acgacacagt 2257021 atacatcgat cgtaattccg tcatccgcca ggtcgacttt gacacctttg ccatgattca 2257081 ctttgccaaa gcgctcaacg acgcctgtcg caaagtttcc gcgcatttcg gcaactccat 2257141 caacttctga tgctgcaatg ccggcaatga cctcaatgac ctccggtgca atctcaacct 2257201 tacccaaatg cgtatcttcg tgatccattt taagcaagct gttgtctttc attcaattca 2257261 cctccgtaaa aattatgagc ccattacatc atatgtttct aaaaatttcg tattaaactc 2257321 tccgctcaca aatgtttcgt gttcaagcag ttttaaatgg aaagggattg ttgtctcaat 2257381 gccttcgatg acgaattcgc tcaatgcgcg cttcatgcgg gcaatcgctt catctctcgt 2257441 ttttccgtat gtgattacct ttgcaatcat gctgtcatag tacggtggga tggaatagcc 2257501 agggtacgca gctgaatcga cacggacacc aagaccgcca ggaggcaggt acattttaat 2257561 ttcaccaggt gacggcatga aatttttgct tgggttttct gcgttgattc ggcattcgat 2257621 ggcccagcct tcaaattcaa catcttcttg cttgaggctc agttccattc ctgaagccac 2257681 tttgatttgt tccttgatca ggtcagttcc cgtcaccatt tctgtgactg ggtgctccac 2257741 ctggattctc gtgttcattt ccatgaagta atagcgctgt tcattgtagt catagataaa 2257801 ttcaactgtt ccagcacctg tatagccaac cgctttggca gcctttaccg ctgcatctcc 2257861 catttgctcc ctgatttctg aatcaagggc aggagatggt gattcttcca aaagcttttg 2257921 caggcgtctt tggatcgagc agtcgcgttc gcccaaatgg atcgtatttc cgtagttatc 2257981 agcaagcact tggatctcaa cgtggcgaaa atcttctatg tatttttcga tgtatacacc 2258041 tggattccca aatgcagttg ccgcttcctg ctgtgtaatc ttaatgccat taatcagttc 2258101 ctcttcagtg cgggcaaccc taattccttt tccgcctccg cctgcggtgg cttttataat 2258161 tacaggatac ccaatttcat tagcaagcga aaccgcttct tccacatttt ctataattcc 2258221 ctgtgaaccc ggtacgattg gcacgccggc ctgtttcatc gtttcccgcg caacgtcttt 2258281 tgttcccatt tttgaaatgg cgtcagcgct cgggccgaca aacgtgacat tcacttcttc 2258341 acataattca gcgaaatcag cattttcagc taaaaatccg tatcccggat gaatggcgtc 2258401 cgtgccagtc agctttgcaa cactcacaat atttgtaacg tttaaatagc tgtcttttga 2258461 tgctttcggt ccgatacaaa aagcttcatc ggccatttga acatgaaggg catctttatc 2258521 agcttctgaa taaacagcga cagtctcaat tccgagctct ctgcaggctc tgatgattct 2258581 gacagcaatt tctcctctgt tggcgatcaa tagcttttta atcatgttca gtctccttac 2258641 tccgctttta caagaaatag aggttgtccg tattcgacca gctggccgtt ttctactaat 2258701 acttcaacga tttcgccttt cacttctgct tcgatttcgt tgaaaagctt catcgcttct 2258761 acaatgcaga caactgtgtt ttcatttact tttgaaccgg ctgttacata cgggccagct 2258821 tccggtgatg aagaagcata aaatgttcct accattggtg aagtgatttt atgcagattc 2258881 tcatcttgct ttggtgcttc ttgggcaggt gccgctgctt gctgcgcttg cggctgaact 2258941 gcctgcggag cctgtgcttg tacaggtgct gccggtgcct gctgcatgac ttgaaccgtg 2259001 cctgcttcgt gttttttcag ttttaaggat acaccttcat tttcatatac gaattcgtca 2259061 attgtagact cgtcaattgc tttaatcagc tcgtggattt ctttgatatt taacattcaa 2259121 tcgcactcct atgtatgaaa tttctttttt tataggttac tactaaaagt acatactatg 2259181 ttcatcttac aggagcggac ttttgaattc aactctaata tgacagcaac gcaaaaagcc 2259241 cgcttgttta gcgggctttt ttccctcatt cttatttaga gggttcaaat gtgacagcga 2259301 catctttcat tgttttgatt tcttttgcca caaggtctat aatggctgtc gccttcgatt 2259361 tagagtgttt gtctgatttg actgtaatat tgattttatc tccttcagca ttaacaagcg 2259421 catcctcgta accttgtgtt ttaatcagcg tttccagctg tttttctgtt ccttccactt 2259481 cactgagagc cgtcatttta tcgtatgctt cgcttttctc cttggctgtt gcatcatcgc 2259541 ttgacacaat ggcattcagc tcttctcttt ctttgcttct ggcatcttct aaatcaagac 2259601 ggtacgttgt aaacaaatca tcatcggctg tttccgtaac aacagttcct ttttcactgg 2259661 cttcagcgga tgtttccttg tctgctgatg aatctttcgt tccctttgtt ccatcttctt 2259721 ttcctttttc agtttctgta ccgctttttt ccttcgtgtc ttgcttggca ggcgcttttt 2259781 cagttgcgac ctctccgctg tcagacgcgc ttttttcact ttgcatctgc acggcgtttt 2259841 tgctttccgg cgacatgata tagtagacgc ttaacaccac gacaagactg agcattgtta 2259901 atagccaaac ggtttgtttt ttaagcattt atgaatcctc ctttattttt ttaggggcaa 2259961 ccgcaacccg gtggcttgga acatccagga cccgtgtcac cgcttcgata atggtttgtt 2260021 ttatttgaac gttgtccact ccttgagcaa caacgagtac accgcgtata tcaggttttt 2260081 tcgtttggac gacgacaggt gtttctttat cgccgttttt gatcatgacg atttcttcct 2260141 ccgatgattg gtctgtaacg cttctttttc cgccttcttt gtcagtttct tcagtggttg 2260201 tatttttgtt tgatttgttt ttttcgtata ctttcagcga cgttgcatct acattcacga 2260261 caaccgagac atcgtccaca ccaatgattg tttcaagaat ttctttcagt tgattttcgt 2260321 attctttttc atagtcatcg atcgagtctt taggtttatc agattttgag gctttaaaca 2260381 cttcggctgt tttctctttg ctgtctgcgg aatgttgtga tgatacggcc gttatcgttt 2260441 tggcgttttc agttttctca ggtgaagaaa acagctggct gacaagcata aaggaaactc 2260501 cgagaacaaa aacgaataga aagtaatgat atttggtcag cttcggcttt tcgccgtcct 2260561 tcgtttgtcc cggaagaaac tgctttttca atacattcca taatccgttt ttattcattg 2260621 ccgacactct ccccgccttc catatgaacc gtaattttct cacttccgat ttcccaaatg 2260681 tccgcgagct gcgtttgtat ctgtttggct tctttttgtt cggctgcttc ttttgttacg 2260741 tatgcatgat ctgtatcaat gtggaccggc gcgaccgttt ggaccgtttt ttcagaagac 2260801 ggggccatat acacgctgat tgttttaata tcctcttctg aatctacctt ttctcctgcc 2260861 gtgagtttga tgcggcctac tttatattca tcatgactga atctctcctc cgctttcttt 2260921 tttagttgga cagccatttc ttctagaata tatgcgcgct gggaagcttg tatttctatt 2260981 ttttttgaat tgatttgatt ttttatgtcg gcagactctg actgcccgtt ttttgtgagg 2261041 tattcaaaga tgacttcggg gtctgtcttg aaaagtttaa aaatcggcgt aagcatgacg 2261101 acaatcaaga gcaggctgac taccattttt gcgtactttt gcatgctgga gctcggcagc 2261161 agcatatcaa tcacaattgc aaataggata aacaacacga tggtggtaag ccattccgtt 2261221 aaaaaactca tttgcctgcc tccttcattt catcatcatc gtgaggtttc cggctgtgat 2261281 tatgacagta aggcttaaaa aaaacatgag agacacaatg gcgagagctg caaaaatata 2261341 aatgacgctt ttgctgatga cgtcgaggca ggtgatgacg ggcccgcctc ctagcggctg 2261401 aagaatcgcg gctgccagct tataaataaa agcgagggaa agcactttga ttgccggaaa 2261461 tgccgcaata cagatcaaaa tagcgacacc gagaatccct accgtatttt tcagcagtaa 2261521 agaggcgctg attactgtat ctgttgcgtc tgtaaacatt cggccaagca caggaataaa 2261581 atttccggtt ataaatttag ccgtcctgag cgtaatgccg tctgtcactg cagctgacgc 2261641 tccctgaaca gagatgacgc cgagaaagat ggtaagaaaa acagccagtg ctccgatggc 2261701 gatatttctg agcaggttag ccagctgcgt tactttgtat tgttcagtca tcgtgctgac 2261761 aatgctcaga atcgctgata aaaaaatcag cggcatgacg atattctgaa tcaagagacc 2261821 gctcgtgttc atcaggaaga ggataacagg atgaaagaag gcagcagata cagctccgcc 2261881 tgaggaagcc aaaagcgcca agaggagcgg aatgagcgcc aggataaagc tggtcatcgt 2261941 ctgaatcgcc tcagttgcat agttaattgc cacatgaaag ctattaagcg caaggataat 2262001 cagcaccatg tacacaattg agtaagcgac cttactgacg gtgctttgct gaaaagcatt 2262061 ttgcaaaagc tgcagaatga cgcaaaaaat cgtgagcaaa atcaatgtgc ccagcagctt 2262121 tccgttggca agcacttcat gaaacaaata agaaaagaga gctttcagcc attcttgcgg 2262181 tgagaatgat ttatcgccat tgataaactc cattaagctg cctttttggc tttccggcag 2262241 cagtccgccg tattctgtca taatgtcatt ccaaaattcc ccgatcttat ctgtttcaag 2262301 cgaggctgct gtcctttccg ctaattgctc ggctgtttca gcatggtctt ccgtttgttc 2262361 tgcattacca gctgcttgta caatttctgc acggcctgct atgatcagca cggccaaaag 2262421 caaaacccat tgaaagcgct tcaatctacc gcctcctttc ggttatgaca tagaaggtat 2262481 aagtccgaga atcgtttcga taatgacggt taaaataggc acagccatta cgagtattaa 2262541 aattttcccc gccaattcta ttttcgaggc gatggctcct tgaccggcat cttttgtgag 2262601 ctgtgccccg aattcagcaa tataggcgat tccgataatc tttaaaatgg tttcaacata 2262661 gaccatgttg acatttgcat taatcgcaat tttttctatc attcgaataa tgtcgtagat 2262721 ttggtctacc aaataaagaa aaatggcaca tccggcaaaa acgacgatta aaaacgcaaa 2262781 agtcggcttt tgttctttta caattaaaga aaggaaggtg gcgatcagcc ctaaacctac 2262841 aatttgaaca atgtcaatct gcaagccccc ctatccttgg aataaaaaca cagcttttat 2262901 ctttttaaat aggtcatcta caatcgtggc gaccataaat aaaatataga taaaacctaa 2262961 cagcgtcacc cactgagcat attctttctt gcccatctga tccaatatcg tgtgtaaaaa 2263021 agcgaccacg attcccactc cggcgatttg aaatatgaca ttcacgtcta ctcccatttt 2263081 atttttgctc ccctcacgtt tacatcaata gaagaatgag taacaagccc gctaaaaagc 2263141 ccaaactttt tatcatcttt tcgtttttcg cttgcgcctg ctcagcatcc gcttctgagg 2263201 cttccaaatg tgtcagcgcc agcttgatgt gcttttgctg agagattcga tcatgaatcc 2263261 caagcgtctc gccaaactgc ttcagcactt cgtattcgct ttttttcaaa gacagggtgt 2263321 cccatacctt ctttaagctt tgctcccacg ccgttttcgc ggaatcactt cccttgtcca 2263381 gctgatcact gaatgcggaa aaaagagttg aaacaggctg tgcgagctgt ttggcaatct 2263441 gctgtgaagc agtatgaagc ggtgtatggc cgtacatgat ttcagcctcg agggattgaa 2263501 gcgccgcacg cagctggcgg atttgccgcg gccgttctgt ataaatcttc gccatctcaa 2263561 aacctgtcca tgttgtcgct accacaatga atacagcgcc cagcagcttc agcatgtttt 2263621 cacgcccgtc gtcctagaca gcacatttcc gtctttgtca taaatttggc tcactgtgcc 2263681 cggccctttt gctcttgata attccaaata gcggtcaaag gctctttctt cccacaaacg 2263741 cttcaatgaa ggccgcttca tcaggtcgga tatactccag ccatgcgccg atacgattac 2263801 tgaaacaccg gcatgcagcg cctccagaag tgcatctgta tcttccatac gcccgatttc 2263861 atcgacaatc atcacctcag ggctcatgga tcgaatcatc atcatcagcc cttcagcttt 2263921 tggacaggcg tctaacacgt caattctctg accaaattga tgctgcggaa taccgcgaag 2263981 acatccggca atctctgacc gttcatcgac gatccctgtc tttacgggca gcatgttttt 2264041 tttgccggtg cttgagagcc tcgcaaggtc ccggagaagt gttgttttgc cggtttgggg 2264101 cggtccgata atcagcgtat tcagccagct gttttgatat aagtatggaa gcagcggctc 2264161 cgcaatcccc agcttttgcc gggcaattcg tatattaaaa gatgcgatgt cacggaggcc 2264221 tttcacacct ccgttttccg taatgactct gcccgccagt ccgactctgt ggccgcctct 2264281 gatcgtgaca taccctttct tcagctcttc ttcaagtgta tacatactat agttgctgag 2264341 ccggctcagg atcagatggg catcctcggc cgtgcccgca taggacaaat aaacaggttg 2264401 tcctcttcga atcaattcaa cagggcggtt gatccgaatt ctgacttctt cgatttccag 2264461 ccattgttgt tccggtattt cagaaagggc gtttttcatg gattcaggga gaacctcagc 2264521 gatttcattc aacagagcct cctcctttct accgattggc ttctttaaaa tgtatgatgt 2264581 gaggcagact ttatgacaag cctctcttta tttatgaaca cccgccaaaa tcaagacaac 2264641 acccgtaaaa atcagaatca gctttgcata cgaaagctgc ccggcaattt ggtagattcc 2264701 gacagtcatt gtaatgataa aaatcaacgg accgacaata gcgagaatgc tgttaaccac 2264761 aaccgccttc cggacatcgt tggtcacaag catgacaatt gctgccgtca gctcaatcat 2264821 agaggataaa actcgtaatc ccgccattgt taaaacagta gaattgatat ttccaagtaa 2264881 aaatttcata gcactctccc aacctcccat ttttttatat gatatgctct agcttgctga 2264941 agtagtcttg tcattttcgt ataaaagaaa gattctgttt ttgggcacaa aaaaagcctg 2265001 ctcccatttg ggaacagact tctttttttc tttctatgct cttgaaacgt aagaaccgtc 2265061 tgatgtattg acaacaagtg tgtcgccttc attcacaaag aacggcacgt ttacaacaag 2265121 cccggtttca gttttcgcag gttttgtacc gcctgacgct gtatcacctt taataccagg 2265181 ttcagtttca acaactttca gctcaactgt gtttggaagt tcgataccaa gtgtttcatc 2265241 ctggtacatc atgatatgca cagacatgtt ttctagcagg tattttaatt cttcttcgat 2265301 ttgagttgcg ctcagttcaa gctgctcata agaagaagta tccataaata cgtgctgatc 2265361 tccgtttgca tatagatatt gcattgtttt ggtttcgatt tgcgctttcg ctactttttc 2265421 accagcgcgg aatgtttttt cctgaatcgc gccagtgcga aggttgcgga gtttagagcg 2265481 gacaaatgcc gcaccttttc caggttttac gtgctggaag tcaacgacgc gccaaatgcc 2265541 gccatctact tcaattgtta atcctgtacg gaaatcgtta actgaaatca tgtttaatgt 2265601 cctcctatat tccaatcaca aaataataag ttcttttggg gaatgggtga ttgtccggtt 2265661 gccgttttct gtaatcacga tgtcatcttc aatgcggaca ccgcctgttt ctggtatgta 2265721 aatgcccggc tccactgtga ccaccatacc cggttcaagg atagctgaag atctgacgga 2265781 taatcccggc gattcatgaa cttccatgcc gagcccgtgc ccggttgaat ggccgaaata 2265841 gtcaccgtag ccttttgcag caatatgatc ccttgtgagg gcgtcagcct cttttcctgt 2265901 cattcccggc ttaatatgtg cgacgccaag cgcctgagca tcaaatacaa cctgatagat 2265961 ctccttcaat tgatcactgg gctgacctac agcgaccgtc cgggtaatat cagaacaata 2266021 tcctttataa taagcgccaa aatcaagcgt aacaaggtct ccgctttcaa tcagtttgtc 2266081 actggccaca ccgtgcggaa ggcttgaacg aaggcctgag gcgacaatca tatcaaaaga 2266141 agagctgtct gctccctggc ttctcatata aaactccagc tcattggcaa cagcgatttc 2266201 agaaatgccg ggtttcataa acgtcaagat atgtctgaag gcatcatctg caatcttcgc 2266261 agcttcctct aatatcttaa tctcttcact agacttaatc aagcgcaact tttccacgga 2266321 ttcagccaca ggcactaatt cggcatcact gataacggcg ctgtatgaag cgtaagtgcc 2266381 atatgtcatg ctgttctgtt caaagccgag acgcttgatg ccaaacgatt caacagtgtc 2266441 ggcagtggtc tgaatcaagc tgccgccatg ttcaatgatc tcaaaaccct ttacctgaac 2266501 cttcgcctgc tcagtataac gaaaatccgt aataaacgct gctttgtcac ccgatataac 2266561 agccaaaccc gccgaacctg taaaccctgt catatagcgt acattagtgt tgcttgtaat 2266621 cagcatgccg tcaattccca gctgtccaaa caggtttctt aatttctcta gcttcatctt 2266681 gattctcccc cttgctggct taataagtag cgaacagcaa gcttgtagcc ttcagctcca 2266741 agaccgacaa tctgcccttt cgcaacagga gcgataaccg actgatgcct gaattcttcc 2266801 ctggcgtata agtttgataa atgcacctct accacaggaa gactgatgct tgaaacagca 2266861 tccctgatcg catagctgta atgactcagg gcgccggggt tcagaacaat cccgctgtat 2266921 tgctcctcag cctcatgtat cgcatctatc aaatcacctt cgtgattaga ctggaagaaa 2266981 gtgagctgga tatgtaaggc ttcagcaaac tgaaaaagat ctgtttcaat atcggtcagt 2267041 gtctggcggc cgaatacttc aggctcacga ctcccaagcc ggttaacatt cggtccgttc 2267101 aaaatcaaaa aatgaggcac acaatctctc cttttcgcga gggtttctca tgtaaaaaat 2267161 gttcacttct cgtgaacatt ttatcatact ggaaaaggat tatacactat tctctatgca 2267221 ttcccagcgc acgtgcaagc ttttccgaat tcagctcatt gtattcaaat gaaatagaat 2267281 acccgacaaa cagcccgtaa agcaaataaa tgcaaatggt cgtaataatt gtatctgatg 2267341 tcagttcggt caccgtgcgc acatctggaa aaatcggatt aaaaacaaaa aacacgagca 2267401 gccaaagcac caagccgtat aaaatacccg gccacattgt ttttaaacgt ttcaatagaa 2267461 gaaaataaag aaatgctgcg ccaattgaaa ttactccaat caaaatgatg ctgattaccg 2267521 ttcccagccc atgttttttc cactctccga gtacaaacgg ctgcaatatc atattcgggc 2267581 tgatttcgga aaaatgaaac aaatatgcga tataagcaac gaaactccaa agtacgcctc 2267641 cgcaaaaacc tgttgccgcc accctgccgg ccattgaaac aggcggcttt tgcttctcat 2267701 tcaattcttc attttgttct gtatcttttt cgcttgtcat catggcacct ccagttaaag 2267761 tgtgcccaaa aaatgaaatg tcaataaaaa agctcacact ttttggcagc tgcgagtaaa 2267821 atttgaaaat aacgggtata atgcatgtag aaaaagcaag gctatggcaa ttttttcagc 2267881 ctgtcaatct agaggtttag cgctgtttcc tgtacaatag agtgaaagga aatggttagc 2267941 aatcctaaag aaataggcag gttgataata tgtcaaaaca taaagttccg cccgcttacg 2268001 gcgggcaggc tgttgtggaa ggcgttatgt ttggcggaaa gcatcattac gttacagcca 2268061 tcagaagaac ggatggaagc attgactttt ttaagcttcc acgcaaacac aacccgaaac 2268121 tgaacatcgt gaaaaagata ccgtttttac gggggatcgc ggccattatc gaagcgagtg 2268181 caaacggcac aaagcatttg aatttttcaa gcgaacgtta cgggctcgat ccatctgaag 2268241 acgagacact tgagcaggaa gaaaaaaaat cctctgggct gtctatgtat ctcagcctcg 2268301 cagttatagg cgtcctatca tttttgttca gtaaattcgt atttacattg gttccagttt 2268361 tcttagcgga actgacaagg ccgatttttt ccttgaacac agcgcaaatc gcgattgaaa 2268421 gcctgtttaa gttgattttg ctgctcggtt acatctattt tttgtccatg acaccgctta 2268481 ttaaaagagt gtttcaatat catggagccg aacataaagt cataaactgt tatgaacaga 2268541 atttgccaat tactgtggag aatgtccaaa accaatctcg gcttcattac cgctgcggat 2268601 caagctttat tttatttacg attattgtcg gcatgtttgt ttatttactc gttccgacag 2268661 atccgctttg gctgcgtgtt atagatcgtg tcgcactgat accggtcgtg cttggtatat 2268721 cctttgaagt tctgcagctg acaaacaaag tgcgtgacat tcccggtctg aaattacttg 2268781 ggtacccggg actttggctt cagctgttaa ccacaaagga acctaaggat gaacaggttg 2268841 aagttgccat cgaaagcttt aacgaacttc tcagactcga agcattgtct gagcaaaatc 2268901 agaagccttc tcacaacgtc atctaaaatc cgttgccctg ctattacttt cggaggtgga 2268961 cagttatgaa tcatcgtgta caacctatta ttgctgtatt aattgcgctg ggagcgttcg 2269021 gtttcctcta tgtgctggta accaatcccg gagaaatggc aaaaatggcg gtaaccgtca 2269081 tcgtggcagg tatcattatt tattttattg tgaaatatgt aatgaatcga aatgcgggca 2269141 gcgaaggagc agccttcaaa aaagcggcga aacaatcacg gcgccggatg aaagaacaaa 2269201 aagcaaaaca ccgcgccgga cataagggac gtgtcagcca cctgcgaagc gttccgagcg 2269261 ccagcaagcc taagccgatg attctcaaga aaaaaagcca gactcagctg actgttatag 2269321 aagggaaaaa aaataaaaag aaaaacagag cgctttttta ataggtccac tgctttaaaa 2269381 acagctctgt ccgtctttta cctagctcaa tcagggctag ttttttttgt tgtgttaaat 2269441 gaaaatcagt ggccattacg tcatcaacag ggagaaaaat gatattttgt tcatagcgtg 2269501 acgcaatgtg ccttgcgtca tgagcatcct tcatcgtttc aaacagggcg ccgaacagtt 2269561 caaaagcgtt gcggatattt tttttcggac gctctctttc acgcggcgca agcgtgacac 2269621 cgatcacagg gcgctttctt tcctttgaaa acagccagat tggaaaattg cttaacacgc 2269681 ctccgtcgac aaccgtggcg gtgcctgtgt ccgtttttaa ttttatcggt tcaaagaaat 2269741 acggaatgct gcagctcatt ctgaccgctc tggcaaccgg gaacatatct ggatttaacc 2269801 cgtaacgggc caaatcgtcc ggcaaaacaa tcatggtgcc gtttgtcaga tcagaagcaa 2269861 taaggcgcag agaccctttc tgcaaatcgc cgaaaaccct tatgcctttc gctcttaaca 2269921 gatcagcaat ccatttttct atcgtatcgc ctttgtataa gccaagacgc cagtagatgg 2269981 acacccactg gagcatcttt aaggggagaa atgagtacct ctgatccagc aatttctctc 2270041 cgtccacttc ttcaattaaa gcgtggattt ccttactggt gtaacctgac gcaatgaaag 2270101 cggcaataat ggcgccggcg cttgtacccg caactctttt aaagcggaag cctttttcct 2270161 caagcacttc ataagcgcct gcgagcgcaa tgccttttac tcctccgccg gaaaacacac 2270221 cgtcaatata catctcattc cctccccctc catccgatcg tttattacca ttttaagaaa 2270281 acacgcgaag aaatagacca acgaatgacg ggtggcgtca gcgtatcaaa aaagacggcc 2270341 tccttcgaga ccgccttttt actgattatg atgttctgtt ttcttttgga ttgatttcag 2270401 atctttttta cgggcatcat cttcttcaaa atattgaaca agatccccga tgcgatcaat 2270461 actgttccag cttaaatgat gttcgattcc ttcgacatcg ttatatattt tctcttcatc 2270521 aacaccaatg attcttaaaa actgctcaag caattcatgt ctgtatacca gccgtttgcc 2270581 tatttttttc cctttagacg ttaacacgag accgcgatat ttttcataaa ttaaatattc 2270641 gtctttatct agtttttgaa ccatttttgt tacagaggag ggatggactg ccaatgcttc 2270701 cgcgatatcg gaaactcgtg catatccttt ttcttcaatc agcatataaa tctgttcaat 2270761 ataatcttcc atacttggtg ttgtcatcga aaccctccca aaaagcacct taactttata 2270821 aaccattaca agtttacact aatgaacttg aaaaaacaag gatgctccgc gggtcaaaag 2270881 ccctgtttac cgcttataat tccattcatc tgaagcgtac tttgtttcag ccaagtgatg 2270941 aacaaaatca agctcttcct gagaaagttc atatggctcc aaatgaatgt taagacctgt 2271001 ttcaaatcct tctttaaagg ctttacgagc ctcatccatc gtcacccgct tttcgatgag 2271061 ttcattaatg gcaaccgctt tatttttgaa attgcgctgc atccgctctc ttactctttc 2271121 acttggatat aagaacagat cgaacagctt gtcctcatct aaatcaagaa gaatggagcc 2271181 atgctgaaga atcacacctt tttgtctcgt ttgcgcgctt cccgccacct tgcgcccctc 2271241 aaccactagt tcataccacg aaggcgcgtc aaaacaaaca gatgaccgcg gattttttaa 2271301 gctttctttt tctttttcag ttctcgggat ggcaaagtaa gcgtccagac cgagatttct 2271361 aaagccttga agtatgcctt ctgaaataac ccggtaagcc tcagtaacag tcgccggcat 2271421 ctcggggtgc tcttccgaaa caattacgct gtatgtcagt tcctgatcgt gcagcacacc 2271481 tctcccgccg gtcgggcgtc tgacgaatcc gagattatat ttatgtactg cttcaaaatt 2271541 gatttccttt ttaatatttt gaaaataccc tacagaaagt gtcgccggat tccagccgta 2271601 aaaacggata accgggggga ttttcttttc gctgtgccaa tataaaagcg cttcatcaag 2271661 cgccatattg aatgcaggac ttgcattgcc tgagtctata aaccgccaag tttctttttg 2271721 cattttaaga ccttccttac cgttttaata gaatcagttt atcaaactgt cgggaaaatg 2271781 aaaaatattt tagttccatt atagatgaca atcacgctgt gctttactat aatagtattt 2271841 gtcgaaaacg gctctatgac cttgttttat gaagcagggt tttgatttta tatgctaaag 2271901 gagtagaatc acattgtcta atatgatcgt tttgattatt tttgctgcat ttatcatcta 2271961 tatgattgct tcatatgtct atcagcagcg aattatgaaa acacttaccg aagaagaatt 2272021 ccgcgcgggt taccgcaaag cgcagcttat tgatgttcgt gagccaaatg agtttgaggg 2272081 cggacatatt ttaggcgccc gcaacatccc gctttcccag ctgaaacaga gaaaaaatga 2272141 gatccgtacg gacaagcctg tttacctgta ctgccaaaac agtgtccgca gcggacgcgc 2272201 ggcacaaacc ctgcgcaaaa acggctgcac tgagatttac aacctaaaag gcggctttaa 2272261 aaaatggggc ggaaagatta aagcgaagaa ataaagcaaa cagctgtctg gtagacagct 2272321 gtttttattt atctttcttc cgcctcgtat ctgagcactg ggtgtctcgc cgcttttgtt 2272381 tcatccattc tttttacaat cgttgtatgc ggggcctcct gaacaagctc cggattctcc 2272441 tccgcttctt ttgcgatttg aatcatagca tcaataaacg cgtccagtgt ttcctttgat 2272501 tcggtctctg tcggctcgat catgatgcat tcttcaacat taagcgggaa ataaatcgtc 2272561 ggcggatgat agccgaaatc aaggagccgt tttgcaatat caagcgtacg cactcccagc 2272621 tttttctgcc gcttccctga taatacaaat tcatgcttgc aatggcggtc aaacggaaga 2272681 tcgtaataag gcgcgagttt tctcatcata taattggcgt ttaacactgc gttctcagta 2272741 acagccttta atccgtcagg ccccatggag cgaatatacg tatacgctct cacattaatg 2272801 ccaaagttgc cgtaatacgg cttcacacgg ccgatcgcat gagggcggtc ataatcaaac 2272861 gtaaagcgcc cttctttttt gactaaaact ggctttggca aataaggaat cagatcttgt 2272921 tttacgccga cagggcctga gccggggcct ccgccgccat gagggcctgt gaatgtttta 2272981 tgcaggttga ggtgcaccac gtcaaatccc atatcaccag gtctcgcctt gcttaaaacg 2273041 gcatttaaat tagcgccgtc ataatacagt ttcccccccg cttggtgtac aatttccgcc 2273101 atctctgtaa tctgctcctc aaacaagccg agcgtgttcg gattcgtcag cataagagct 2273161 gcagtttctt cattcactgc tctttttaaa tcctctaaat caacaagccc tttttcattc 2273221 gatttcaccg taacggtttc aaagcctgct actgttgctg atgcaggatt cgtcccatgc 2273281 gcggaatcag ggacaatgac cttcgtccgc ttgaaatccc cgcgagcttc atgataggca 2273341 cggatcatca tcagccccgt ccattcgccg tgcgctccgg cagcaggctg aagcgtaacc 2273401 tcatccattc ccgttatttc ttcaaggtgt ttgcttaaat catataaaag ctctaatgcg 2273461 ccttgcaccg tgtcttcatc ctgaagagga tgaatcgcag caaaaccagg aatacgtgcg 2273521 attttttcat tgattttcgg attatatttc atcgtgcaag aaccgagagg ataaaaaccg 2273581 gaatccaccc cgtgattgcg tttggacagc gctgtataat ggcgcatgat gtccagctct 2273641 gaaacctccg gcagcgctgc gtcttcgtca cgaatatagg tgtctgacaa gaggtccccc 2273701 aattcgattt ccggtacatc gagctccggc agactatagc cgattcggcc ttctcttgaa 2273761 agttcaaaaa taagtgcctg gtcctgatta ctcatggcga tcccccaatt cctgaatgag 2273821 tgcgtcaatt tcttcttttg ttctcagctc tgttacagca atcagcatat ggcagtccag 2273881 ctctggatac gtcaacccaa gatcatatcc gccaatcatg ccttttgcca gcaaacgctt 2273941 gttcacagct ctcaccggct catccagttt gatgacaaat tcattaaaca tcggcccgtc 2274001 aaacataaca gtaaggcctg ctttttttgc ttcttgcttt gcatagttgg cttttaagag 2274061 attttggcgg gctatatctt ttacgccgtt ttttccgaga gcagtcatgg ccactgatgc 2274121 tgccagcgca tttaaagctt ggttcgagca tatatttgat gttgctttat cccggcggat 2274181 atgctgctcc ctggcttgca gggtaagcac aaagcctctt tttccgtttt cgtcttccgt 2274241 ttgtccgacg agacggcccg gcacctttct cattaatttt ttagtaacgg caaaaaagcc 2274301 gcaatgcggg ccgccgtatg ctgaaggaat gccgaaaggc tgcgcatcac cgacgacgat 2274361 atcagactga aacttgcccg gcggagtgag aagacctagc gccagcgggt tggctgaaac 2274421 aataaacatg gatttccctt gatgagcgat aggctcaata tcctttagcg gctcgatcct 2274481 gccgaaaaaa ttcgggtact gaacgatcac tgcggctgtg ttctcgcaaa cggtttggcg 2274541 caatgcatca agatccgtaa cgccatccgc agcgggtact tcaacaacat caatatactg 2274601 accttttgcg taagttttca gcacctctcg cgattcagga tgcacggttt ttgacacaac 2274661 aatttttttc tttttcgtgt ggcctgaagc aagcattgct gcttctgcca aggctgttcc 2274721 gccgtcatac atcgaggagt tggcgatatc catgcctgtc agttcacaga tcatcgtttg 2274781 gaattcaaaa atagcctgga gctctccttg tgaaatctct ggctgataag gcgtatatgc 2274841 ggtataaaac tcagagcgcg aaatgacatg atccacaatg acaggctgat agtggtcata 2274901 tacacccgct cctaagaaag aagcgtattg tacggtatca cgatttttag aggccagctt 2274961 tgtcagttct cttgttaatt ctgtctctga tttcgctttt ttgatttgat gctctttttt 2275021 atatttgacg ttttccggta tatcagcaaa taaatcatcg atgctgctta cgccgatagt 2275081 agcaagcatc tcctgtttat ccttttctgt tgcgggcaaa taacggtgct tcatgtgttg 2275141 tctcctctct ccaagaaaaa atattagcgt ttataaaatg gtgttttgac aacctttgct 2275201 ttcactaatt ttttgcgtat ctctacatct acaacagtcc cgatctcact cgtttccgaa 2275261 tcaattaagg caaggccgac gttttttcct aatgtcggtg actgcgtgcc ggttgtcacc 2275321 tttccgacag acttgccatt ttggaaaacc tcatatccgt gccgcggtat ccctttttca 2275381 atcatttcga gaccgacaag tttgcgcttc gctccgtttt ctttttgttc actcaatact 2275441 gacttaccga aaaagtcaga ctcctttttg tgctttacag caaagcctat acctgcttca 2275501 atcggtgtaa tatcccgggt cagctcctga ccgtagagcg ggagcttcgc ttcaaaccgg 2275561 agtgtatcac gtgcaccgag accgcatgga atcaatccgt atgcatcccc tgcatcgatg 2275621 atttttttcc aaatatgcat agcatcatca ctgcggcagt aaatttcata cccgtcttct 2275681 cccgtatagc cagtgcgtga aataagtgct ttgcggccgc tgatatcggc ttcatcaata 2275741 aacgcaaacg gctttaatgc agacacatcc gcatctgtca gattttttaa gatcgcttct 2275801 gctttcggtc cctgtacagc caagagcgcg atttgatctg actgattgtc aatctgcaca 2275861 tcacctgctg catgttcttt catccaagcc aagtctttat ctatattaga agcattaatg 2275921 acaagcagat agcggttctc tcctttttga tagataagca aatcatcgac ggttccgcca 2275981 tccgggtaac acatcgctgt atattgagca cggcctggcg ttaacgcgga aacatcattt 2276041 gtcatcaatc tttgcaaaaa agacagactg tcgttccctg acacttcgac ttctcccata 2276101 tgagatacat caaacaaacc ggctgcagtt cggacagcct cgtgttcttt ttttatagaa 2276161 gaaaattgaa caggaagctc ccagcctccg aaatcaatcg tttttcctcc atattcctta 2276221 tacaggtcaa ataacggcgt tcttttcagc atctaattcc tcccctttat caacggcgca 2276281 gctaaaaaac atacaaaaaa ggacagagaa acacctcatg taaaatgaag gttctctgtc 2276341 ctggcacctg aaagtttact ttgcatacgc aaagacgtcc cctttggtgg tttgcgcatc 2276401 cgcacaaaca ctctccagag ttgcgtcgag caagagttct tttgcctgag agattcactc 2276461 cgcagtttgc tccttcggcg cctgtatccc gaggttttcg gtcaggtctc tccccttgct 2276521 gtcattcgct catattttca tgctgttatg gacatactat agcaatatct tacatcaaat 2276581 acatactcat atcctaccat catcactata tgctgggcaa cagcaatttg ggcagatttt 2276641 tcttatatta ttcatcttaa gaatcgaaga ataagaaagg cggtttcaaa gcaatgaata 2276701 cagaaatgat ctacgatgca aaatggcctg aagaatttgc tgaaagactg aaaaacgatg 2276761 gcccttgggc aaactgggaa ctgtacaagc tctctgcaga aatccagaaa acattagcaa 2276821 ttccagagtt tgaaggctta cgggctcctt tatatctgcc ttcctttacg ccgctccccc 2276881 accagcttga agtggcgcaa aaagtggttg aaaaaatgaa cgggaaagcg attttagcag 2276941 atgaggttgg tctcggaaaa acggttgaag ctggactgat tctaaaagaa tatatgattc 2277001 gcgggttagc aaaaaaaatt ttgatccttg tgcccgcttc ccttgtgtca cagtgggtca 2277061 aagagcttca ggaaaaattt ttgattccgg ctgttgaaca aaagaaaagc tatgtgtggg 2277121 agcaatgcga tattgtcgtc tcatcaatag acaccgcgaa gcgctcgccc catcgagaaa 2277181 tcgttctgtc tatcccatat gatcttgtca ttattgatga ggcacacaaa ctgaaaaata 2277241 gcaaaacgaa gaactatgaa tttgtccgga atctcgtaaa aaaatattgc ctgcttctta 2277301 ccgcgacgcc aatccagaac cgtatcgaag agattttcaa tttggtgtcc ttattaaaac 2277361 ccggccattt aggcagtcag aatcactttc aggaggagtt cgccaagaag aaatccagtt 2277421 tagaagcgca tgaacattta aaagatcttg tgaataaagt catgatccgt aacaggcggc 2277481 atgatacagg gctgaattgg aaacagcgcc atgttgaaac agtgccgatt caattttctc 2277541 catcagagca ggcgctttat gatgaaattt ctcgtttgaa ggacagtatc aataaaccag 2277601 ccagcatgtt ctcgattatg accttgcaaa gagaatgctg ttcgagcaga gaagcggtat 2277661 atatgacgct gaaaaagatg cttgatcaaa aagagaaaca agcacctgcc attgatgagg 2277721 atacgatttc agttttgata gatcgcatca atcaagtgac acaaaactct aaagcgcttc 2277781 aagttgttga cttgatcaaa aagatcgacg ataaggtcat catttttaca gaataccgcg 2277841 caacccagat ttatctgcag tggtttcttc agcaaaacgg catcagttct gtgccgttta 2277901 gaggcggatt taaacgtgga aaaaaagact ggatgaagga tcttttccgc ggaaaaatcc 2277961 aagtccttat tgcaactgaa gcaggcggtg agggaattaa cctgcaattt tgcaatcaca 2278021 tgatcaacta tgacctgcca tggaacccga tgcggcttga gcaaagaatc ggaagaattc 2278081 acagactcgg gcaggagcgt gacgtgcata tttataacat ggcgacaaaa catacggtgg 2278141 aagagcatat tctaaagctt ttatatgaaa aaattcattt gtttgaaaaa gtggtcggtg 2278201 aacttgatga tattttaacg aaaattcaag tgaacaattt tgaagagcac cttcatgaca 2278261 ttttgtatca ctcagcaaca gaagaagaaa tgaaaataaa aatggataac ttaacctcat 2278321 ttttgtctta taaaaaacag ctgcctgctg aaaaaagagg atcttagcct gtaaggaggt 2278381 tttattagtg agacagcaag aggttcacga ttttctgctg cgtttttttc aagcaaacag 2278441 ctgccaaatc gtcgatcaag gcttaggcta tatgacagtg cagcttacag ttgaaatgga 2278501 caaacaaatc atgaaccgcc ctttctactg gcattggcgc gagaagacag gcggtgatcc 2278561 gaatccaatg aaaatcactt ttattacaga taaagaaaat gcgccaaaag acctagatgg 2278621 tgaatttata tattttgggg ccccgcgtct ttttcaaata ttcaaagctg ttaaacaaaa 2278681 tgggagattt accagaatgt atgagaaaat tgaatcagcc ggagctaaag tcccacttca 2278741 gccttggctt ggtataaatg tcacgatttc ataccagtcc gacatgaaaa aggataagtt 2278801 attgtcacta ggtcttcacc tagtctctgg aacgataatt gaagattttc aaagcaagct 2278861 gacccagttt tcactgacgt ctcaaatatg tgactattgc ttcaccattt cacctatgat 2278921 caaaccagaa agcggactta agcgtatgga aaactatatt tccaaatccg ctatgcagga 2278981 gccgtccgac tgggcggaac aggcggttaa caggtggaag aatgatatga cattgcttga 2279041 taagttttac gagcatatag aagaaaaacc agaagaatac catctagaaa aacaggcgct 2279101 gaaaaccttg tatcaaccaa agatatcagt tgaaattgaa aatggcggat tgttttatct 2279161 gcaaaataat atttcaagct aactttttta ccattcgaca tcattctcgt tttttttgag 2279221 aaaatacgat tataataaag gtatattgga aaaaaattct ggtgatttaa tggcaaatga 2279281 cttccagaga ctaatgaagc atacaataag tcatggccgg actggctgaa atacataaac 2279341 aagtatttta ggaggagaaa ctgcatgaag aatgcaaaac aagagcactt tgaattggat 2279401 caagaatggg ttgaattaat ggtggaagcc aaagaggcaa atatcagccc ggaagaaata 2279461 cgaaaatatt tacttttaaa caaaaagtct gctcatcctg gtccggcagc cagaagtcat 2279521 accgtaaatc ctttctgaat gtgctataat atcacaagga aggtgatgac attgattggc 2279581 cagcgtatta aacaataccg taaagaaaaa ggctactcac tatcagaact agctgaaaaa 2279641 gctggggtag cgaagtctta tttaagctca atagaacgaa atctacaaac gaacccctcc 2279701 attcaatttc tcgaaaaagt ctccgctgtt ctggacgtct cggttcatac tttgctcgat 2279761 gagaaacatg aaaccgaata cgatggtcaa ttagatagtg aatgggagaa attggttcgc 2279821 gatgcgatga catccggggt atcgaaaaaa caatttcgtg aatttttaga ttatcaaaaa 2279881 tggagaaaat cccaaaaaga ggagtagtgc ctgagcagag gcactaactc ctcttttgtc 2279941 aataaccatc gagacggccc agtatatgaa tactgggccg tctctttttt ttgctgttat 2280001 taatttttat cctcgctatg cgctttttca ttttctttca cgtaaccatc tttatcagta 2280061 tggtcctttt tgattgtcaa gccgttccac tgtgtagctt cgaatgagaa ttgaagctta 2280121 atggagttgc cttgatattt attttgaacc ataagccctt tttcatcttt tgttttatca 2280181 tccttgaatt ggatttccat ttgaacctga tcgaagtcag ttggtgtttt tggaacacca 2280241 tcatattcag gagcggtttt accatcaatt gttgctacat tgactttacc gcttgcattt 2280301 aagaatttag ggtcaatttg ttttttgatt ttttcagcag ccgctgcatc atttttagca 2280361 gacatcaaat acaagtcttt aaggttcgca tcatctaaaa taatgttttt cgggtagcca 2280421 ttgccgccct cttttccaac tgtcaacaat gtcacttcaa actggctgag gaaatcttct 2280481 ggagatgtat tgctgccgcc gtttgcttta aaatctccat aattaagcgc cattagaact 2280541 tctttgatcg caagtgatcc gttattttca aattggaaat cctttgtcaa cttatctccc 2280601 ggctttagat ttgataagtt cacactcgct gaattctctt tagcagataa atcaagcgta 2280661 cctgatgcaa aagtagcatc ctttgattta atgtcgttaa atgctgccca tgttcctcct 2280721 ccaactaaag ctaatcctag tgctgcagaa gcaactccta aactcaattt ctttttcata 2280781 cccatggtaa gctccccttt tattgaatga ttttatatcg aaacctgttg ccaggtttac 2280841 aactgaagtt aagtagacat ggtgctgtcc tttgtatctg tttccaaggc ttttgtcttt 2280901 ctttcaattt ctctaatggc gctgctgatc gtcacaaaag cgtaaactaa cagcatcacg 2280961 ccgggaacaa tcaataatac agccgttcca atcggctggc tggcaaaatg aagcatatag 2281021 ccggcatatg gaagctgaaa acctgtgtat tgcgcgcgaa cattttcgtc cgatacaggc 2281081 gctgaatcag ctgctgcatt attatcacct tttgttttaa ataacaaatg gtctccttgc 2281141 tttgttatgt caacaattct gtgggtgacc gccgtatttg catcctgcat aaatgtaata 2281201 acgtcacctt tttggagctc tttcacatca gtgatttctt tgaccaatat taaggaacct 2281261 gtattgaact ccggctccat cgaacctgac agaactgatt tcagcgtata cccaaacact 2281321 gccggctctc ccccggatga acgtgttgaa atcacgacaa gtgtcagcac aataataaga 2281381 gtaaagatga tcacgtataa aatattactg atcagcttca ttgctttttt catcctcttc 2281441 cccgctttcc ttctggtctg attgagtttc tttttctttg gttacagctt cttgagatgt 2281501 ttcttctttc attgtttttt ccggtatatc tttttgtgtt gtttcattct cctttttgac 2281561 gtccgacttt gtttcttttt tagggactgt cggtttttca tcgcattttg caagcctcat 2281621 aggctccgac cactcaaatg tactgccgtt tgccgggtag cctgccggtt tatatacttt 2281681 aaatgcataa atgccgggtt tcattttttt cttggtctca attttataaa gtgaatcgcc 2281741 gatttgattg gagacaaatc ctttttcgat cacgttccca tcctttaacg gtttgcgggc 2281801 attttcaagc ttatgaagct cccacttcca ctttgatttc ttaagtttct cacctgtatt 2281861 ttcgagcaca gcaaataagg cgaaaggtga gcatacagtg cctttcgtat ccgtttgatc 2281921 tgatatgtgc aaatcacttt gatcccagcg tttatcataa tggcagtttt tatctgtatg 2281981 ctgaaagtct ttacacgttt gaagtgagac atcaaatgtt tcaatatcat gaaaagcagc 2282041 gcttgtatca tcggaaaatt gtaagcatat tgcggcagtc agactgaaaa tgactgaaag 2282101 ctgaaagata agcagaactt tcagtttcgt cttcgccttt tgctgattgt gaaacaatcg 2282161 aaacatatct tacctcctgt aaaacactgt aacttgatat gacaatcgtt ctctttaaag 2282221 aacttcacaa atagagtata atcaacgatt tatagattta aaaacaccga aatcgctcat 2282281 tttgttcgtt taaaagaatg ttttcatcat attacaaagt cttgctcagt attgctcatt 2282341 ttttcaattt tttagaaatt tttgggattg ttatgtgaga atttaaatgc atatcccatt 2282401 attatttggt aataataaac aaagaaaggg tgacagcatg atgatcaaac aatgtgtgat 2282461 ttgtctatct cttctcgtct ttggcaccac agccgctcac gcagaagaaa caccgcttgt 2282521 aaccgcccgc cacatgtcca aatgggaaga gattgctgta aaagaagcaa aaaaaaggta 2282581 cccgctcgca caggtactgt tcaaacaaaa agtatgggac cgtaaaagaa aagatgaagc 2282641 agtgaagcaa taccatttaa ctctgaggga agggtcaaaa gaattcggcg tttttgtgac 2282701 gatttcattt gatccttata gccaaaaggt caataaaatt gccatattag aagaatatca 2282761 ataaggtcct ccattttttg aaggacctta ttcgtttatt tgcggttatt ttttccgttt 2282821 cagccaaagt cggaagccat agggtaaaat accgaaccac tgctgggaaa caggcgtttt 2282881 tgtttctttc cgcacctctt ttcgttcttt tcgctcatct ctcggagtat ctatatattt 2282941 gacaaattgc tgcgtcatat atttaacata atcattcgtt ttcacgtgat cacctcatca 2283001 ttcaattatt atgagtgttg tctcacatga ctttttttat accctttaca ctgttttatt 2283061 ctgtccatct cagcagtttt ttctgttttt ggtcaaacac gatctgtgca gttctttctg 2283121 ttcccgaatc cgttgacact cttaagttga tttctttttg ttcttttatc gatgtatcat 2283181 gaatgtaata agaaacccgt ccatatagaa attgctgcgt accctcctgg cctttccgtt 2283241 cctctagaac atgccgaatc gaaagaagca ccccattttg aagcaaattc tctcctatgt 2283301 ataactcttt tgtttccttc tcaaacatgc agcgtgaaat atattgagca gcaacaaagt 2283361 tcacgattaa cagcacaagc gctgacacaa aaagaacagc tggataaata aaccctcttg 2283421 tacgatacat tcacccccct cctaaatacg aatagactgg aaaagcagtt tgatacactt 2283481 tttggtcttc actctcaatt ttcagcaaaa caacaccatt ttcaatatca gctttcatgg 2283541 cagtaatatg atctaaaatc ggaacatgcc ctttgccatc cactcttttt cttatcattg 2283601 aatgataaat gtcaaaacgg atgtcttgtc cggaaagatt ggtgcagatt aacacgctcc 2283661 catgctcggc tgtcttaact gcctgtgatt ccttgcattc attcatcatc tgttctatcg 2283721 aaatcatcca ttcctgctgt gtgaaaccgt catgttcctg ctgtcgagac aaaaacagat 2283781 ggataatcgc agctaacgat cctgatatga gcaaaaagac tgagagcgaa aataatacgt 2283841 taagaagcgt gtagccattc tgtctgcaaa atgctgaggc aaaatgattt ttctttataa 2283901 gctgcggctt tgatacatac gttttgatat tcgccctcct cctcccactt cattgcatag 2283961 atatgattgt tctttgtaat cgtttttgac gcggctcctt caccactcat gacatatttg 2284021 ctaatgctct cattcatcat ctgatagcca atttctcgtg attccgccat tttttcatca 2284081 gccatcagct tgtcccacaa ggggacgact gtcagcagca caaacagcca caggcttagc 2284141 gcagacattg tttctattgt agaaaaacct ttattttctc tccacattga ctctcccgct 2284201 ccctagataa actgttatgt cataaacggc atggcctttt actcgtattt ttccgcctgc 2284261 attcgggtgc cctttctcat taaattccaa acggtctttt aatgtcagca gttctataga 2284321 aagtcccgtt gcatacggac gttcaataac cgtatcacca atgactaatt gatattcttt 2284381 tttatgaaag agaatttttg ttctttgttg acgggaaata gcagtctgct gtgtgagcat 2284441 aatatcattt ttcagctgac ttgctgcctg tcggacagct gtattgtcat aagcaggagg 2284501 aagtgtagtg aagacggcca ccaggaggat agaggcaagg cttaacacaa gcaaactttc 2284561 taaaagggta aaccccttct cctcgtttaa tttaatgttc aaccttaact tctccgccgg 2284621 tgatgataat gcgcttacca tttggacaga cagcatcctt tttcacatag ccctctgact 2284681 gtaaatcggc aaggctcgga gtttgtcctt catgatcaag ctcaaatgca gtcatttgtg 2284741 ccttaaccat gttttgtaag ccttcacagc cctttttttg aatggtttga ttatgtttcg 2284801 tgacgttcgg tatcgtaatt aaaagcaaaa tcgaaataat aaagagcacg attaacattt 2284861 caacaagtgt aaatcctttc tcattcatca gcctcttcct ttcacatttg attcatcatc 2284921 tgatacatag gcacaagcat agataaatac acaagtaaga tcatcgctgc aacaaatcca 2284981 taaatcattg gctgaaggat gcctgtccat ttttgcgctt tgtgttccag ccgctgtaat 2285041 atgaattggc tgtatgtgaa aagctcccga tccaatcggc cgctcagctg gccgtgagat 2285101 atgacttttg ataaatcagt ttcataaaaa aggcttccac aaatagcgga ttcaattgac 2285161 tcaccggctt ttagccgttc aatcaattgt tcagcctcgc agcggtagaa agggagaaac 2285221 gtttgatgtt taaatgcatt aaggctgtca taaattgaga ggcctgattt taaaaggctg 2285281 cttagctgca aagaaaaaaa gtagctgtta aacagcttta caagctttcc aaccaaagga 2285341 atcctgatac aaatcagcat ttgccgggca ggtgattttt tcttaaacac aagccaataa 2285401 taaatcccga tacctgctgt aaaaagaaca agcaaaatga tcacaagatc aatatgctga 2285461 aaaaaagcaa aaagcatatc ggttgaacgt gaggtttcca tattcatcga ttgatagata 2285521 ccggaaaact gaggaatgat gatggactgt aacatataaa acatgacagc gaccgtaaag 2285581 atgaggaaaa gcggatagcg cagcactctt ttcagctggt ctgcctgtgc aatttttcgt 2285641 tccagcagct ctccgctctg gatcattgaa gcaggcagtt caccatgtgt ttcagcaaaa 2285701 taacaaatac ctacggcttc cttatgaaat gacaaactct ttagtacttg ataaaacgga 2285761 gccccttccc tcaaacaagt gaccgaatca gtcaagtcag ccgcctgcct cttattcatc 2285821 tgaagttcca tcaggcgtaa tccatccaga agtgtatatc cgcccgcagt catttcaccg 2285881 agcctcttta ataacctggc ttgatccttt aacaaccaga cttttctaat ctttttcatg 2285941 ataaacccac cggtcatagt tgtttgtcgt taaatagccg agcgcaattc cttttctgat 2286001 aatttgacga agcgtttgat attggtaatt tgcatgattt ccttttgcct cctggataca 2286061 ttgctgaaga tttttcccgt atagaagctc ataaacgcta gctctcctag tatttcgtga 2286121 ctgtcggcaa tacactgatg aacatccgtt ttcacaaaac gggcaagcca aatcaaccaa 2286181 gcgctgagcc gctattgcaa tgacagtctg ttcgatttca ttcatattga taccgaattc 2286241 aagcagtctg taaattgcgc cctttgcgtc tctcgtatga aggctcgtta gtaccagatg 2286301 tcccgtcatc gctgcccgca ccgcaatttc agctgtttcc gcgtctctga tctcacctaa 2286361 aataatcata tcggggtcat ggcgcaaaat tgctttcaga cctgcggaat aagttacacc 2286421 ggctttttca ttcacctgaa cctgaagaac atcttcgtcc cttgtttcaa cagggtcctc 2286481 taatgtgaca atatttcgat taaagtgttt ttttgcatat tgaacgagag agtataatgt 2286541 ggtagtcttc cctgaaccag tcggcccggt aaaaatgagc atgccatggg aatgttttaa 2286601 aaacgagagt aatgtggctc ctgtcttcgg aaatagcgac aatttatcaa tcgaagggat 2286661 attgtattgg ggcatcactc tgatcacgag gctttcttca ttaattgtgg gcagcgttga 2286721 cattcttaaa tgaacatttc cctctttcaa ctttaacgta agcgaaccgt tttgcggctt 2286781 tcgcctttca cctatatcca ttgctgaaag aaatttaaaa tgtgaaatca gtcttacgca 2286841 ctcttctttt ttcatgtccc tttttttcag caaggcatga tcgacccgaa aatgaatgat 2286901 agcgtcccgc tccctcggca caatgtgaat atcagaagcc tttgttagat atgcctcttc 2286961 aatcaagttt ttgcttacct tttctattga atccaatttg attccctctc ctttcaacgc 2287021 atattgtaga aaaagaagaa aaggtaatca aacagggaaa acgtgatttt gtgagatgtt 2287081 atatgctgaa aaaccaattc tttctggcaa gaaaaaagac tttcaactga atgtacccct 2287141 gtcattataa ttttccctat aaataaaaaa gcagacatgg tcaccatgcc tgctagattc 2287201 cattttcatt atgctgtttt cgcttattga ccagtatctt tctcaacgga aagatcgcct 2287261 aatgcaacaa taccggtcat ttggtcattt tcaagaatcg ataaactgcg gatttaatgc 2287321 tctgtcataa gccccttgac atcgtatccg gtcaccctga tatgtctggt gaaaaagcgg 2287381 ggcacgctgc acaaaatatg aaacatccta tagagtccgc ctttttcgag gtttcttttt 2287441 cttcttccgc tcctgcagca tatctcccgt ccagcctttt tttctcaaat agagatagat 2287501 cagaactgta gatgtgacaa tcaataagag ggaaaagaga tatccgtatt tccaattcag 2287561 ttccggcatc actgaaaagt tcatccccca taaggcaccc agagctgtaa tcggagtaaa 2287621 aagcgtcgtg aaaatggtca gcgcttttac aatttcattc cccctatgtg aggtaatgac 2287681 ttcctctgaa tgcagcagat tgttaagctc cccttcaaat tcgctgatgt atgtaaatcc 2287741 cctgtcaatc ttcagttgtg tccgctgata atcctttttc ccttcatttt gaggtaaaaa 2287801 ggtttctttc aacgccattt caattttttt agcgcttaat atcaaatttt tccaaatcat 2287861 cagttcatgg cgcaggagat ggacgcggtt taaaatgctt ttgctattgt cgtctttaat 2287921 ttgccatctg agctttctca gcttgacttc aaattcatca acaccgatta aatacgcatt 2287981 cattagttcg ccgagaagaa ttaaaaaccc ctctatcgca ttgtccgctc tttccatttg 2288041 ccgaacaact tctttgcctt taatctctct caaaattgaa aagtcaaagt tgattgtaaa 2288101 aaaatattgt ctggtgatat aaaagtgaaa aacagtatgg tctttttctt caccaagccc 2288161 ctgatcataa acaatcgacc caaatactgc ttcattttcc gtttcagttg tatctactcg 2288221 caaaaaatta acgtgatggt tattttcaaa ccacttttca cactgaggcc agtgagaaaa 2288281 atggattaga tctcttgcct tacttctttc ttgaggcccc atttggtacc aaaaccaatc 2288341 ctttcccgta tgtgccttca tgtcaagctc ctccaaactt ttgttcttta ttctttaatt 2288401 gcccaataac cgcgtcacta aaccagtctg ccgcttcaac acatgtttta tgagcatttt 2288461 caggtggtat ggaatgtaga aagacatcgg aaaagggagg tgcatgcctt ccttggagaa 2288521 ggcagttgtt ttggaattta tcaatttact agcagtcgct attctcattt tgttaacagg 2288581 atttttcgtt gccgtagaat tttcaatcgt aaaagtgcgg cgatccaaaa ttgatcagct 2288641 tgtcgcaaaa ggaaagaaag gtgctaaagc ggcaaagcat gtcatcactc accttgatga 2288701 atatttatca gcctgtcagc tgggcatcac agtcgcagct ttaggactgg gatggcttgg 2288761 ggaaccgact gtgcaaactc tgcttcgacc gctttttcat aaagcaggct taaatgaatc 2288821 gcttacccac ctgctttcac tcgtcatcgc atttttagtg gttacgtatt taaatgtcgt 2288881 tattggggag ctggcgccaa agagtttcgc cattcaaaaa gcagaaagca ttaccttgtt 2288941 gttcgctaaa ccgcttattt ggttttataa gatcatgttt ccattcattt ggctgttgaa 2289001 ccactctgcc cgattgatta caggagtgtt tgggctgaag ccggcatcag agcatgagct 2289061 ggcttataca gaggaagaac ttcgggtcct attggctgaa agctataaaa gcggcgagat 2289121 cagaaaaagt gaattaaagt acatgaataa tatcttcacc tttgataaac gaatggcaaa 2289181 ggaaattatg gtgccgcgaa atgaaatggt tagtttgtca ctagatgaag actccatttc 2289241 aaatcttcag gaaacagtca agcaaacaaa atatacacgg tacccggttg taagagagga 2289301 taaagataac gtcattggcg tgattaatat gaaagaagtg ctgttttcca tgctgacgaa 2289361 agatttttca atcaagaagc atcaaattga acctttcgta cagcccgtta tccatgtaat 2289421 tgagacgatt cctatttata aactattgct gaaaatgcaa aaggaacgca ctcatatggc 2289481 gatcctcata gatgaatatg gcgggacgtc cggtttggtc actgtcgagg atattatcga 2289541 agaaattgta ggagaaatcc gtgatgaatt tgatgcggat gaagtgcctc atatccgcga 2289601 acttggaaag gatcattact tgttaaatgc aaaattatta atcagcgatg ttaacagcct 2289661 gcttggaacc gatttatcag aggctgaagt agacaccttg ggcggctggt ttttgacaca 2289721 aaacatagac gctgagcctg aaagtgccat agaatatgat ggctactctt ttaaggtaaa 2289781 agacatcaac agccatcaca ttttatttat agaagttaaa aaagctgaat agcccgtgaa 2289841 aggctgttca gctgctatct ttcaagataa acatggcaaa ggcatcaaca ctcttttatt 2289901 ttaaaccctt tattggccag ggctttagca agactttgct ctgttttcac attcgaaaaa 2289961 tccagaccca gcttcacgac agtttgggca atttccggcc tgattcctga aataatagtc 2290021 tcaatgccga gcaatttggt gctgtcaatc actttaaaaa tttgataggc taccatggta 2290081 tcaacgatag gaacgcccga aatatctaaa aataaatacg agagctttaa cgctgagcac 2290141 tgctccagca cagactccaa aatcgtcctc gctctgtgcg tatcaatttc accgacaagc 2290201 ggaagaatcc caattccatc agtaatcggc ataatcggcg cactcaattc attaatcatt 2290261 tctttttgcg cgtttaattg tatcatggtc acctggtgat attcttccgt aaacacttcg 2290321 atgatctcat caatgttttg attcaagatc cggctccact cataaaattc ctgaatgctg 2290381 atgtcttgag aagaagcttc gctgaattta tgaatccatt caaacatgat gtgcctgaaa 2290441 gtgttaaact ggccgacact ttgtgtaacc gtcacttcat gaacggcacg gtctctggcg 2290501 cattgaagag accaccggtt gagctcatcc tctacgtctt cttttctaag ggattttgct 2290561 acgatggtca ccaataattc atgctggtct tttaactttt gttctagttt ttgctgatct 2290621 ttcgctgaat acagccagct gccgtttgac gtacaaactt ccagccattg ttgcgtaata 2290681 tcttttttgt gctctgttaa gtgctgatca agagctatca tcttaatgag ttacctcctg 2290741 tttttgaaaa atgtacgcta tatatgtata acgcgtctgc ctttacacat actatgttta 2290801 gattcaatgg gctatagcca agcggtaagg caatggactt tgactccgtg atcgttggtt 2290861 cgaatccagc tagcccagtt tctgaacagg tgaaaaaccg aagataagct gattcgtata 2290921 aatcagcgga tcttcggttt ttcatcatgc agattgatga accgttttct tcttcgataa 2290981 cttcaacagt tctcccgggt tataaccaat caccagcttt ttgttgtcta ctagaatcgg 2291041 gcgtcgcaaa agcttcggct tctcgattaa aagttccagc acctcattta ccgtcatttc 2291101 ttcaatgttt aaatttaaat ttttgaaagt ctggcttctt gtcgccaaaa tttcatcaat 2291161 tccttctgtc gttaacgata aaatgtactt taattcttct cttgtcgggg tttctctgaa 2291221 taagtgccgt tcgttaaatt caatttgatg tgctttaagc caatgttttg tttttcggca 2291281 tgacgtgcag cttggatatg agtaaaaagt taattgttgt tccattcgtt ttttcctcct 2291341 cagttaacca tctctttgta gaataactac ccggatcatt tttcatttaa accatttaca 2291401 gaactttttt cggattattt tttaaaaaac attcatacaa tagaaaacac aatcaaaggg 2291461 acaaattcca tttgtatatt aataatgaaa atgtttacat ttctaggtgt gatctattat 2291521 aataacagtc agagggactc tcgggagggg ataaaaatga atcgcatgtt ccgggtgtta 2291581 ggattttgga cgggaatttt tgcagtcatg ttttatttag gtgatatgaa agatgcttcc 2291641 cttttatttt ttggacagac gatcttattt gtgtttctat cgtatttgaa cttaaccgaa 2291701 cgcatgtata tttatatttt tggcgcttat ttaacaattt tcttcgccgg ctttacatat 2291761 tactcaattt ttattatggt gcccggcggc ggaggccatt aaatgcagaa agagacaaac 2291821 cttatcggtt tgtctctttt tttacaatga aaacccattt aaaaacggat tttgatcctg 2291881 ctcagtcagt acgtctgttt caggtccatg gccgcttaac accagcgtgt gttccggaag 2291941 cgtaagcagt ttttcatgaa tggacgtcag cagcgtctct tgattgccgc ctattaaatc 2292001 cgtacgtcct ataccgcctt ggaacaagac atctccggaa atgaccaagt ctgcatcttt 2292061 cacgtagtaa gacacactgc ctggtgaatg tcccggcgta aataatgttt ccaaatgaaa 2292121 cggcccgata ttcaactcac cgtcgccttc aattagatga tctgcaggct tagctgtgac 2292181 ttctatccct cgcagcatgc cggagccgtt taaagaagcg tccgcaagcc aatttttttc 2292241 attttgatgc aggtaaacag ggatatccca tttttctctc acttcatcaa gcgccccaat 2292301 atggtcaaaa tgggcatgtg taagcaaaat ggctaaaggc gtcagccctt tttcttttat 2292361 gtattgattg attttatgtc cctcgccgcc cggatcaaaa atcagacatt gatcatcact 2292421 gatgagaaaa tatgcgttcg cttgaatcgg ccctactggc attcgtctcc atttcactat 2292481 tatcacctct ttctttttta tgctcttatt atgagggttt ttgaaaaaag attcaaacaa 2292541 tcgcaatgaa aacgctatcg acaaacctat aaaaaacagg tagaataaaa ctggaaagaa 2292601 ttgcaggttt ttcaatgtaa agggggctgt gttatgttac ttgtcgtgat tttcggcctt 2292661 gtcgctcttt tcgctttatg gggagtcttg cgttctgtta gaaataaaaa tatactcggg 2292721 tttttattag ccggtgccac cttatttgtc tttggatggt ttaccgtgat gaccgtaata 2292781 aacagcgggt atccaaccgc acattaaaac ctgtatccga tcggatacag gtttattttt 2292841 atggctgtaa atgtttattg acactttcta ttttgctctc aagcgtcgtt tttttgtcac 2292901 gcctgtcatc gatacggata ttcgttgcca ctctgtgcaa tcctttttga aatggcgctt 2292961 cgtgaattgc ctgaataact gcaaaaaggt cactgagttc tccctcgatc agcgtattca 2293021 tcggtgtcag ctgatatttg attttccctt ctgcttgata tccttctaat atcttttgca 2293081 catcggctac gtaagcactg acactgggtg tttccgtacc gattgggata atggttacat 2293141 ctgcgatagc catcgttatt ccatctcctt ttgatcaatg atgagttgct tcgtttcatg 2293201 tgatttcaat aaaataattt gctcaaaatg aaagccgtat aacgcatatt tcccgttcgg 2293261 agatatttga atcggctcca tttcccgcag agacacaaga tcttttgtct ctcccgatgc 2293321 tacattgatt gctgcgagct tatatgcatc gccgctttgt ttgaatgtat aaaacaggcc 2293381 tcctgcttca tcatagtcat actccattgg agccaaactt gtatatttcg cttggagcgg 2293441 ccatttcgct gtaacaggtg atgttgattg cggcgtttta aactgatacg tcccttttcc 2293501 tccggaagct gatttgacag taaaactcat ttgatggaaa gaatcgaaga atagaacgtt 2293561 atcctcaagc ttctgttccg tcttagaagc tgtatcgaac gtatataaag gccctgtttt 2293621 atcgtctcta ccctctttta cataatcaaa tgtatttttg gatgtccaat gaatgaacgg 2293681 aacctgtact gggcttaaga aagattcgtc ttttttagca ttcacctgat atgtatggaa 2293741 atcccagttt tcattgaatt ccgtcaccat catttgataa ggatcatact gattccaagc 2293801 agcttcaagc tcatacgttt cgtaatcttt ttcgtaaagc gtctctcctt ctgcattaag 2293861 caaaaccact gccgtctttt ggctatgtgt gatttgcagc agaatcatct gctccctcgc 2293921 attgatttga acatcaacga tttgaccatc cgtttgatag agctttttcg ctttgcctgt 2293981 aaagatgcgg tacgcaaaaa gctctgtttt cgtcggatta gacgcagtat ataatattgt 2294041 gctgttattc agccagcctt ccgccccatc cgctttttcc gcggaaagcg gtatgatgtc 2294101 ttttttctca tcttttgccg ccgatgcctg tttttgctgc tgatgagatg gttcgcatgc 2294161 cgataaacta aacagcaata ccgccagcag aataaaacaa actgatctca tcagcattcc 2294221 cctccgatca tctttattct ctcatatttg cttcggcaga aaaaagaaaa agtttcagtt 2294281 actcatgaaa aaataacgcc ctccacaaga taccgcttgt ggcgttatat atgtgtgaaa 2294341 actgctgaaa cggcaaagga ttttggcctt ttccaagttc caccgtatac ccttccttaa 2294401 aataatggtg aataaaccaa tcacgaaatc cagcatagct gtctatatcc cttactccct 2294461 tataaatgtt cccgcttaac tcctcaaact cctttatgac ggcagcagat tcctcaggct 2294521 caaggccttt atagccccaa taaatttctt ctccttgagt atgaagagcc agcagtctgt 2294581 caggcggatt ctccgtgatc agccggtaca tcgcaataga ttccggctcc gtaagcggag 2294641 agattcccgg aaaatcgcgg tagctgggtg ctgtcggttt tcggtatttt tcaatttccc 2294701 ataatgatgg aaattgttta tttaaatcaa ccccgtttat attcgccttc cattcattaa 2294761 aatttggacg atgttcattt agcctttcga gttcatctct tctggctccc atgacttctg 2294821 atccgtttaa aacaagatca acgccatccg gattgacaag aggaacgagg gataaggatg 2294881 tgctgttaaa cagctttatg ggagaaaagc caaagaaagg cgaattgcag cataatgaca 2294941 tacagtattc cttaaaccat tttagcagga cagacgttgt aatccactca ttcgcatgaa 2295001 atgacgcgtt catatggacc ttttttacgg catgctcccc accagccttc agctcccaga 2295061 taggcctgcc gagtacagaa cggccaattt cccggcatga gacaaacgga aaaacatcaa 2295121 taatcttctt tatttccttt tcaacagctg aatcatcata gattttctct tgctcaatcc 2295181 agctatctga aagtttcagc tgccgaggct gtaaaaagcg ctttatgtcc tgaatggttt 2295241 gaagctcttt gccgctatgc tcctctatca cataaccagg gcaatacaat tgatgttttt 2295301 gtgcggagcg atttgcactt ttaagcaatt cctcgtctat cttcagttct ttcgccacat 2295361 tggccaaatt gttcttgatc tcaggtttca ccgtaataaa cgccatcatc atcccccttt 2295421 tttgttacta tatgacagcg tatttaaaaa aagaaagcct cccgctcact tcgatgcggg 2295481 agacattgtg attatgatgc ctgatcaagc atttgttttt ctttccgctt tgacgaattg 2295541 tccagccttt tctggtcata aaatcgcaac aaatccccat aaatgatttc atcagaaagt 2295601 gatagctcct gttttgcttt atcagcaaat gcttcacatt gttttgtctc ttctaacggt 2295661 tttcccgtct ctttgtcata acacgcaccg tctgtataaa caacctgatc tgtgataaag 2295721 ctcccgtccc ggagcaccgt gaagtccagt ttttcgtctg aaagcagatc gttgccgaat 2295781 tgaatttgat ctttcgtatc aatccctaaa agattcatca gcgtcggcct gatatcaatc 2295841 tgcccgccta ctgtttcaat ggtttgcggc tttttatcag taatacccgg aatatgaatg 2295901 accagcggca ctttttggag ctgtacctct tcaaatgggg ttatttcttt tcctaaaaac 2295961 tgccccatcg cttcattatg gttttctgat ataccataat ggtcaccata taatacaata 2296021 acagagttgt cgtataaccc gtcttccttc agcttttcga taaaccgttt cagcgcctca 2296081 tcctgataac gcactgtcgg aaaatattta tttagcgtct ggctgtttga atcatattca 2296141 tcaatcaatt gatcctcttc atcaagatca aacgggaagt ggttcgtcag tgtaatcagc 2296201 ctcgagtaaa acggctgagg cagatttttc atcagctctg aggactgctc aaaaaattct 2296261 ttatccttaa gtccccagcc gactgaattt tcgtcagtta catcatacga gttaatatca 2296321 aaaaacgaat catatccaaa tgagtcgtac attaaatcac gattccaaaa gctcttatta 2296381 ttagcgtgga gcaccgctga atagtatccg ctgtttttca aaatttcagg agcggccata 2296441 tattgattgc ccgcattcgt aaaaaatacg gcacctcgtc caagcggata cagtgaattg 2296501 tccacgataa attcagaatc cgaggttttc ccctggcctg tttggtggta aacattatta 2296561 aagttgtagc tctgttttat aaagtcattc agaaaaggcg tgatttcttc tccattcaat 2296621 ttttcattaa tcacgaagct ttgcgtcgac tctaaggata cgagaatgac gttccttcct 2296681 tttgcagcgc cgaataagcg tttgttggca tccttcgcat tagcggttac gtagttttca 2296741 atctccgtca ggctgttgct gtctgccaac gctctctgtg cggattgctt tgactgaaga 2296801 acgccatcgt aaatatgaaa attaaacagg ctaatgtttt taacaagcat ttctctgtca 2296861 aatgagcgtg tcaatagctg aggtctttcc gcctcagaca agcccaggtt gaagaaataa 2296921 acagaagcaa cgaacaaaaa ataagccgcc cgttcatttt tcgttgaggg aatgtccgat 2296981 tgaaaagctt tttgccggat gtgaagccat attaaaaccg caatatctac agctaatagg 2297041 aggtctgtcg gctcaagaag tgttccgatg ctgcttccga gatcacccat attgctcgtt 2297101 tgaaaaagaa cagggattgt taagaaatca ttgtaaaaac ggtaaaaaac catatttgcc 2297161 agcaatacaa acgtgacaag acagctcatc gcgataatgt agcgatttct gtttttgcct 2297221 tttaaaaaca ggctgaggcc aaaaataagc aacaaaaaac tcaatgggtt gataaacaga 2297281 ataaattcct gtgttagatt gtcgatttta atatgaaaac tggttttgta aacagcatac 2297341 gttttcagcc acatcaataa aatggcaatc agcataaatg aaatcttcga aaaaaacgtt 2297401 tttcgcattt caacctccta tgcagcacgc tcaaaaaaat cagtctattc ccaacattct 2297461 cattaacaca tcaaattaaa tcttaacctg agcacaacaa aaaatcaatt tcatttacac 2297521 aattttaaca attttgatgt ttcagccatt catttttagc gatccaagcg cctccgataa 2297581 cgccggcatc atttccaagt gctgcgattg aaatatcagc agcttgggct gcccgcggaa 2297641 acgcgcattt gcggaatgtt ttctcgactt ttgatctcag cagttctccg gctctcgata 2297701 cgccgccgcc aagaacgatt ttggatggat taagcgagct tgccaaattt ccgagcacca 2297761 aaccaagatg cttggctaca taatcaacca cctcaagggc aatttcatca ttttcacccg 2297821 ccgcttcaaa cacatctcgc gctgacaatt gttcggttgc ttttaaacgt gtcgtctttt 2297881 tagcatttgc tattttttct tttgcaattc ttacaattcc ggttgctgac gcaattgttt 2297941 cgatacagcc cgttttgccg cagttgcagg gcgctccgcc ttcagggatg ctgcaaatat 2298001 ggccgatttc tccgccggcg ccatttatac catgtacaat ttcaccattt gcaatgatgc 2298061 cgccgccaac tcctgtgcca agcgtcacga gaatgacgtc ttttgcgcca tcacccgctc 2298121 ccttccacat ttccccgagc gcagcaatat tcgcgtcatt ttctataaca gctgggatgc 2298181 cggtttctgt ctccagatgg tttttcaaag cataattttt ccaccctaga tttactgttt 2298241 cataaaccac tcctgccgcc atatctacag ggcctggtgc acccattccg atgtatttga 2298301 tgatgtgctt cggtttttgc agctcatcca gcttgctgtc gattgttttt gcaattgtga 2298361 cagtaatcgt gtcgccggtt ttatctgtcg gaacttccca cttatgctga atttcgccat 2298421 attgattaat aaaagcgagt ttaatcgtcg ttcctcccag gtcaatgccc gcaaaccata 2298481 tctcgtccat ttttatcacc ttagccttta taaaaatctc ttccgttttt tgtttgttcc 2298541 aattcttttc gaaggacagc tgccgctctg gcccactgct ccttttcaat catgtggttc 2298601 atgtataatt cctttaattc atccagcata aactcaattt caagctctct gtctccaaaa 2298661 taaacaatgt ggccaaacgt ttttaacagc tgctgcacat cataaaatgt attcattttc 2298721 ctcaccattt cttgaactta actatcataa gcgtattcat aaggaagcgg tcagtcaaga 2298781 agaaaacgct gacaaaaaag ccagcttcct ttccatattc cacctctatg attctttatt 2298841 gttttcaatt tgccgctgca gctccttgta gcgctgctcc ttcggcttca gtttcacagc 2298901 cgtctggatg gccttttctg cttgtgcaag ctcatttttt tccgcataca ataacgctaa 2298961 attgtaatag gaagcatggt ctttaggttc ttttttcact gctcgttcca aaagggaaac 2299021 cgcctgatca tattcgccga tttgaatatc agaaacagca agaattttca aaagatcggc 2299081 agaggcatct ttttgcgctg cttctccgtt cagcaattct gttacttctt catactttcc 2299141 ttcctgatac agctcgcttg cctgctgaat cagcgctgac tcctggtgtg aaggcgaatg 2299201 caatccgtaa tataaaaatc caacagccaa agcaatcagc aaaaccgctg acaacaatct 2299261 ttttccaaag gctccggctt taggcaaccc cagtgctgct gcagcgaaaa agccgccaat 2299321 caagccgccg atatgtcctg aattatcaat attcgaaacc gcaaaaccaa agcccagatt 2299381 gatgataata atgacaataa tattggttcc tatagttctt aaaaacattt ttcgattaga 2299441 caaagcaaca tacagtaatg cacctaagca tccgaatatg gctcctgatg cccctgccga 2299501 aggatacggg ctgaacacaa aactcgcaat cgaacccgta atgccagcag ccagataaat 2299561 cagcaaaaat ctccccgatc catacatccg ctcaaccgct gtaccaaccg accataaagc 2299621 cagcgtatta aaagctaaat gcgctatgcc gatgtgaagc acgatcggtg tcagaagccg 2299681 ccaccattct ccttgtgcaa tcaggctgtt ttcttttgct ccaaaagcca ccagtgtctc 2299741 cgtattagtg ctgcctccgt ttatttcgag caagaaaaac atcaggatct gaagcgcaat 2299801 aaataaatat gtaaaagtcg gttttccgtt ttgaaaaacc gccgcttcag tttttctctg 2299861 ttcttcttgt ttcagcacta gcgaaaggaa gcgttctcgc gccatttgcg cgttttcaaa 2299921 cgaagcgtgt tcctctgaac aatcttctgt acgaaatgat ggaaaaaccg cttgaagatc 2299981 atctcgaagc atcgttcctc taacgatcgc cggctcaact gacacagttc ccttctcaaa 2300041 agtttttttt gcaatctctt cccagtcatc aactggggct tccgttgaaa aaaacacgtt 2300101 cagcagcttc atccttcgtc tgcccaattg atgtctgact cgttctactc gttcggcctg 2300161 ctcttcgatg tctctaacca tttcttgacg gaaatcaaga tcgtgcttat aaagacgaac 2300221 tagatcatga gaggacttgt ccggcgcttc cagccatatt tcatctgact caccggcttg 2300281 tatgacgcca tacccgctat tcaccaggtg cgccgcaatt ttccaatatg tatactccag 2300341 caaaaacatg tttaccgctc caatagtttt ttttcattat aacagctggc gctccgaaac 2300401 gcctactgaa agcaaaaaat cccgtttttc acgggatttt agaaagcttg ctgtataaac 2300461 ttattgcgga taaatggaat tcttaaaaac aaatggataa aagaccgcct gattcctggc 2300521 tggctgagta cagtattcat aagacggtag cgattttgat aaaacatgac ggcagaaacc 2300581 gcgaaaatgg catatatcaa aagttttttc atgatatccc tcctgccaat agggtttgtt 2300641 attctacctt atttattctc gaataaggga caggaaagtt atgaaaaaca agaaataatc 2300701 cgatcctctg ttatcagctt atgtaccggg atgtcatgcg gcagacgggg tacgtgcgca 2300761 aacaactggc actccaaaag caaagagact gtcttccctt catattcact taaatagcga 2300821 tcataatagc cgcctccaaa gccgacccta aacccgttaa catcaaaaca aacacccgga 2300881 acgatcatca agtcaatttg tgatgggttt acttcttttg ttttttcaat taccggctcg 2300941 agcagtccgg cgtacacggt ttcgagctga tcatcagtct gatatgtgcg aaattgcatt 2301001 ttcttcgtgt ccggatggca ttttgggatg caaacttgtt tcccttcttc ccaagcctgc 2301061 tcaatgacag gacgcgtcgg tatctctaat cctctggaaa tagtgacggc aatggtgccg 2301121 gcattttgcc actccggcag agaaaacaag tacttataca tacgttccgt tttttgaaga 2301181 atatcttcat ttgataaagc agacagtgcc tccagcgtct tttttcttaa ttgtgatttc 2301241 atctctcatc cccctcggaa tagaaaaaaa gccagaacct ttttcaaagc tctggctttt 2301301 ttcttacacc tcaaacagca aagctgttat tttgtttcac ggtgtaacgt agatttttta 2301361 tcacgtgggc aatatttttt aaattcaacg cggtctggat tgttgcgttt gttcttttta 2301421 gaaatatagt tacgctcacc acattcagtg caagccaaag taatattaac gcgcattatt 2301481 ttccctccaa actaaaatca tttacttatt cagacttata tataatacca ctataatgga 2301541 cggaatgcta ggctgttttt caatgaattg ctgaattatt gaagatacgc tcataaagct 2301601 gcaaatatga tgacataatg agtcgggggt ggtggagctt gaacacttgt tgtctgccag 2301661 cttcttttat ccggcgggct ttttcccggt cttttaaaaa actgtccagc agatcagcag 2301721 cttcctgtac gagcgtaaaa tcagcgatga ttgccgtttt gtcatgaacc gcataatcac 2301781 aaaaaccacc tgactgagaa acgacagtca gcacaccttg ttccatgctt tcttgcgcgg 2301841 caagcccaaa cggttcataa gaactaggga aaacagccat ttcacagtga gacagtaacg 2301901 ttctgatatc tttcctattt agaaacggca gaaacatgac gcgatccttc aggttatatg 2301961 ccgcagccaa tttctcatag caggacagag acggcccctc cccagccagc actagataga 2302021 ggtcaggctg acgctgcttc aagatggcaa acacctttaa cagctgcgat aatccttttt 2302081 ccggaacaaa ccttccatat gaaaagagga atcttctatt catgcttctc gggattttcc 2302141 ccttctcttc ctccatagat gcagggcttg ggataacggt tattttctta tgtgccgcct 2302201 tatcaagaga ccgcttcata aatgtgctta atacgatcaa tgcatcagcg gattctataa 2302261 ggagccgttc ggtcatgagc ctgtatgggt gtggggcttc tcggcacacc ttcttccttt 2302321 cgctttcaag accgtggatt gtcgcagcaa gcggaaggcc aagccgttgt ttcaaatact 2302381 gggcggcagg ggcagttgtg tcatcatggg catgaatcag atcaaagcgt ttattgtgtg 2302441 ataacacatg gcgaaccatt gtaaagttag catcagctat gtaatcttca aacttcgcat 2302501 acgaaaacag ctgcccgctc ggagtaaaaa ccgtaatgtt gatatgaggg tttaaatagg 2302561 aaatgaggcg gtttaaatgg acaccgagcc cgcttttcgg ctcatcggga tgttcgggtg 2302621 aaagcatgag aatgttcacc gttctttttc ccctctccca taacaggtgt atgcagaaaa 2302681 ttgcgcctcc cacctggtgt gcgcttcttc aatctgaaaa ctgtttatat gacgaatccc 2302741 attttcatca agatagatgt cgtctgtacc ggcaagcttg agagagacat tcattgaatt 2302801 cacaattctg tattcagccc gatatacagc atcaccagcc gcctgtctaa tcgtccattc 2302861 tcctttatca tacgttgtgc gttttgtcct gacagcttca atgtcttttc ttttgatgac 2302921 aatgcgcaat tcttttatca tatcctgcgt tttttcgaaa aggaccgctt cagccagccg 2302981 cattgtttct tctgagattt cccagcttac ggtcaaggtg tgagcgtttt gaatgattat 2303041 gtcgaatgtg tccctaaaaa aggaaagctt atgtcgtata ttatagggaa atgggtgttt 2303101 atccatggac tcctaacatt ctcctttcca atcgttcact tcgtgttcct attaaaccat 2303161 tacatgaaga agaagcgaag aaagatttct cgacaaaatc tcgttttttt cgcgaattcc 2303221 tttagaaact attggtttta tggtataaaa aagaaggata aaaaaagaat agaaggtgat 2303281 gaaacgtgga aattgctatt attgcgttgt ttatcgtcag tatagcgcta attgcattct 2303341 catattctca aagagacccg atgaaagatg tagaacagga gctcgaaaca ctgcagcttt 2303401 ctgcgatgca ggaaatttac aagctcaaaa agaaaatgac agtgcttgag gaagaattac 2303461 tggaaacaaa ccttgtcatt cgcaaatcaa agcagaacga catcaatcaa aaaatcgcta 2303521 aacaaatact ttctaaatat aataacggta tgtcagctga agcgattgct aaagctgaac 2303581 atgtatcagt ggaagacgtg aatacgatta tcaaagataa tgagaaggtg ctcgtatgac 2303641 aaaacggggc attcaggcat ttgctggcgg catcatttta gcgacagccg ttcttgcagc 2303701 tgttttttat ctgactgacg aagaccaggc cgctgctgta aaagataata aaacagtaac 2303761 cgaacaagac gtgaacaatt atcttgattc taaaaaattg gtttctgtca accgtgatga 2303821 atatcaaaaa cttctcgatt caaaagagaa atccttaaac aatgacagcg gctcagacac 2303881 gaaatcagac aaagtcaaaa cctacaagct caccattaaa gacggcatga gcacggcgga 2303941 tgtatctgct attcttgaaa aagagggcat tatctcttcg gctcaagact ttaatgacta 2304001 tgtcattgat gccggctatc acaaagaaat tcgtgccggc gagtttaaag taaaatcaga 2304061 catgagtttc aaaaagatcg taaaaacgtt aacacgataa aaaaacaggc tgactcagcc 2304121 tgtttttttc atccaaactt tcctgaaatg taatcgagcg ttctttggtc cttcgggtta 2304181 gagaacattt tattcgtatt gtcgcattca acaagctcgc ccatgtagaa aaaggcggtt 2304241 tgatcagaaa cccttgctgc ctgctgcatg ttatgcgtga caatgacaat tgtatattta 2304301 tctttcagct ctagaatgag ttcttcaatt tttctcgttg agattggatc tagtgcagat 2304361 gtcggttcat ccatcagcaa aatatcagga ttggtcgcaa gtgctctggc gatgcaaaga 2304421 cgctgctgct ggccccctga cagcgaaaga gcggacgtat gcaatcgatc cttcacctca 2304481 tcccataacg ccacgtcttt taatgacttt tccacaattt cctgaagctt cttcttattt 2304541 ttggtgccgt ggactctcgg tccgtaagcc acattatcaa aaatagattg cggaaacgga 2304601 ttcccttttt ggaataccat gccgatattt tttcgcaaat ccacgatgtc cactttatcc 2304661 tttaaaatgt tgctgccatt atagttcagc tcacctgcaa gctttacatt cggcgtcatt 2304721 tgaatcatta aattcaatgt cttgataaag gtcgatttcc cgcatccgga tggtccgata 2304781 atcgccgtaa cctcattttc ataaatgctc aaattgatat tttttaaagc atgatgctgc 2304841 ccataccata agttcattcc attgacttga tatacttcct gtttcattac agcttcggta 2304901 gcaatactca ttgccgccct cctatccgaa tttcccgtta atataatcct ctgtcttttg 2304961 ctttttcgga ctcgtgaaaa tctgttcggt ctgtccgtat tctacaagct cgccgtttaa 2305021 aaagaatgcc gtccggtcag aaacccgcag agcctgctgc atattgtgcg tgacaataat 2305081 aattgagtat tctcttttca atcctgtaat taattcctct atttttgcat ttgaaatcgg 2305141 atcaagcgct gaagctggtt catcaagcag aagaacagcc ggcttcatcg caagcgttct 2305201 cgcgatgcat aaacgctgct gctggccgcc ggataacgag agtgcggatg aatgtaaacg 2305261 atccttcacc tcatcccaga gcgctgcttt tgttaaactt tcttccacaa tttcatctaa 2305321 aacagcttta ttccgctctc cggcatattt caatgcatgt gtgatattcg catagatcga 2305381 tttcggaaat ggatttggtt tttggaaaac cattccgatt tctcttctca agctgacaac 2305441 gttaatattg ccgcccaata tatttaatcc ctcataaagg atttcacctt ccgctcttgc 2305501 agatggaatt aaatcgttca ttcggttaat atttctcaaa aaagtagatt ttccgcatcc 2305561 cgacggccca attaaagcag tcaccgcatt tttttcaata tccatgttta catgatgaac 2305621 ggcttgttta tttccgtaat aaatggacag atctttgacc tcaagcacgt ggttctgctt 2305681 cggaacaata acagctcgct caggtttttc ttttaccatt tgttcagaca tgtttttcgc 2305741 ctctttccgt tctaatttgc cgtaagcttt ttgtagatca tcgtgccaag ccatctcgcc 2305801 gcgagattaa acacaagaac agaaatcacc agcacggcag aaccaccgtt ggcaatcgct 2305861 tcagcatccg gaatcattcc ttgtgtattg acgttccaaa tgtggaccgc aagtgtttca 2305921 gcgggcctga aaatattaag cggtgatgtt tccgaaaacg ggttccactc cgtaaaatta 2305981 agacgcggtg ttgtcaggcc tgccgtaaat aataatgcgg ccgcttcccc gaacaccctt 2306041 cctgacgcta aaattgctcc tgtgatgata gaaggaatcg cacttggaat taaaactgtt 2306101 tttacggtat gccagcgtga tacacctaaa gcgagagagg cttccttcag atctttaggg 2306161 actgaacgga tcgcgtcttc tgtcacacgc accatgacag gaaggttaaa aacagttaac 2306221 gcaagcgctc cgcctatgat cgtataaccc cagcctgtta agttgacaaa catcaataat 2306281 ccaaacatcc caatgacaat agacggaaga gatgaaagca cctctataca tgttctaatg 2306341 aagtcagtta ctttgttatt aggcgcgtat tcagccatga agactccgcc gcccacaccg 2306401 agcgggattg taatcagcat tgtaataaac aaaatataaa aggagttaaa cagctgatct 2306461 cgtatgcctc ctccagctgc aatggcgctc gactttgttg taataaattg aaaactgagc 2306521 tgagaaacac cgtttataat aatataggaa aacaaaccta ctaaaatggc agcgataatg 2306581 gctgcacaca aaccaaacat tccggtcgcc agtttatctg ttattttgcg gttcattaca 2306641 ctttcctcct agatgacaag tagcgaataa gcaggatgaa caagaatgac atcaccagaa 2306701 gcacaagccc cattgaccac agcgtattgt tttcaacact tccgtatgtg gtgtggccca 2306761 tattcagcgt gatgatcgtt gtcagcgttc ccgcagtgtc aaacgggctt tccggcaata 2306821 ctcttgtatt tccaatgacc atctgaacag ccaaagcttc accgaacgcc cgagccatgc 2306881 ctaacacaac agctgtcatc aatgttggaa aagctgcagg cacaagtact tttctgatcg 2306941 tctgccatct tgtggcacca agcgcgtaag aaccctctcg taaactcttc ggaagagaag 2307001 ccattgcatc agcagaaatc gatgtgatcg tcggcagaat catgacggaa aggacaatcg 2307061 ttcccgccaa taaactgtgc cctgttccgc tcgatttgaa ctgggcgata aacggcacca 2307121 atactgtaag acctatgaat ccataaacaa cagatggaat accgactaaa agctcaatca 2307181 ccggctgcag cactttcttt ccccaattcg gggcaatctc tgtcataaaa atcgcacctg 2307241 caatgccaag cggcgcagcg attagagcag aaagaatcgt tactgcaaat gagccaaaaa 2307301 taaatggcag cactccgtat ttcggatcac tatctgtagg attccaattt aagctcgtta 2307361 agaattcaat tgggcttaca ccatttacaa gaaaagattg cagcccctta acgccgagga 2307421 aaatggtaat cgcaacagat gccgcaatca taatcagtgc acaagctgtg actatcattc 2307481 ttccccgaac ttcatccaat tgccgatttt gcctagagct gattaagcgc tcgctcacag 2307541 acatattttc tctattgttt atcattgttt tacactccta tgaatgtgtt aagaggagaa 2307601 acggttgtcc ccgcactcct ctttttatta agatcagctt tgcttcccgt tggcatcacg 2307661 tgtcactttc atatcagtaa ccggaatgta gccttggtca gtaacaatgc ttttttgaat 2307721 gtcttcactc tttagataat caagaaattc tttagctaaa cctgtcgctt caccttttgt 2307781 ataagaatgt tgataagccc agatcggata ctcgccagtt gctacatttt tcgcttcagg 2307841 tttaacaccg tcaatagata gagcagttac tttgtcatct gttaaatatg agaatgcaag 2307901 atatccaatc gctcccggag tatcagcaat gatctttttc accgtgttgg aggaatcttc 2307961 agtaatgcct tctgcaggct ccgctccgtc aagcgcatat ttcacaaatg tagcacgtgt 2308021 gccggaagaa tcagggcggt ttacaagtgt aatcttttgg tctttgccgc cgagctcttt 2308081 ccagtttttg attttgccag tgaagatttt tttcaattca tcttttgaaa tatcctttac 2308141 accagcatca gggtttacag ctgctgccat accaactaca gcgacttgat gatcgacaag 2308201 cgcttttgca tcgatgcctt ctttttcttc agcaaaaacg tctgaattcc cgatctgaac 2308261 agctccttca gagacttgag aaagccctgt tccagaaccg ccagcttgta cctgtatatc 2308321 agcatcaggg ttttcttcca taaatttttc cgcggctgca agtactagtg gctgcattgc 2308381 cgatgaacca gaaatggtta aagaacctga tgccttttct tctccttttg cagaatcgct 2308441 attcgatttt ttactttctc ctgcatttcc gcatgcagct gcaatcatca taaaagcagc 2308501 catcagaagc ataagcacca atttgttttt tttcatttcc tgaattcccc ctgcgtataa 2308561 tgtgtaattt gtcctacacg tatagagtaa aggttctatg taaaaagggt ttgaaccgaa 2308621 tgttaaggtt ttgtaaatca gtgcgttttt tgtataaaaa aaacgcccac atcatgtgag 2308681 cgtttttttt tagttatcag aagacgttgt gttttctgca ttttcttcaa ttttgtcttt 2308741 attcttttgc tgagtacctt ctttgtcctg cttcgatttc agctcaaaat atttatccat 2308801 tacttccctg ccgatttcgt ttgtaattga gtatctttga ttgtaatcaa tgtaagtcca 2308861 aggaactacg acagaaatag caatctcagg attgtcagct ggtgcataag ccacaagcgt 2308921 cgtattataa gtgtctgttc ctgtttttga tttatccggt ccgtcgtaaa atgattgggc 2308981 tgttcctgtt tttgcagctg gtttatacga tgctgaagcc agttgacctg cagctgtccc 2309041 tttagtggca acccgtctaa aaccggcttg gacctcttca atatagctac tcttcatatc 2309101 gactttattc aatacttcag gctgaacaga atcaacgact gcgccgatcc cttttttcgc 2309161 atttgaatct ctgacttcct ttacaagctg aggcttcatg cggtagccac catttgctat 2309221 ggtggagaca tattgagcca attccagcgg tgtataagta tcatactgtc caatggcgaa 2309281 atcaagcaag aaaccagata atctgcttgt acctttatat cccgtcattt catttggtag 2309341 atcaattcct gtttttactc ctaatccaaa ttgactgaaa taatttctga aggtatcaaa 2309401 tgcagaagta tccaaaggca atgcttggtg aggtttatat tcacctttac caactgcaat 2309461 tgctgtttta aacataaaaa cgtttgatga cttctctaat gcagtttgaa taccaaccgg 2309521 ccctaagttt tgccaagatt ttttccctct tttatcctgg ccgatataca atggttcatc 2309581 cttaaataca gtattcaaat taatcgctcc agtttgaaga ccggtcaaaa cggttgcacc 2309641 ttttacagct gatcccatag cgtaggatga agtcatggct cctaatgcat aatcatcaaa 2309701 cttataggct ccattttctc gtttaatctg cttccctgcc attgtcagca cttcgccgtt 2309761 tctagggtcc atcatgacaa cgaatgcacg atccaacaat tcggtactag gtcttgcttt 2309821 agcagcttta agttttttct caataatttt ttccactgat ttttgcaaat caatatcaat 2309881 tgttagtaca agatctttcc cggctttgcc ttcagatacc gtttttgttc ccgtgacatt 2309941 gccttttgaa tctgtgatat tttcgacttt tgctttttgg ccctgcagaa ggctttcata 2310001 ttggtattcc agatagcttt ttccgaccct gtcatttcgg ctgtagccaa gcgacagata 2310061 atggtcgagc aagttggacg gcaatccttc attagagctg gaaacacttc cgagcactga 2310121 gcgaagaagg tttttataag gatattcacg ttcccaatcg gacgtgacat caacacctgg 2310181 cagttcgtct aaatgttcac ttaccactgc catttccttc gctgatacat cttcgttttt 2310241 gatatattga ggggtcaatg catagcccga atccatctgt cttttgatag caaggatctg 2310301 catatcttta tccgtcaatt cattcagctg cttatcagta atccgtttta gctgaagctg 2310361 gtataaatcg tcatcggata tttttttgtc ttcaacctgc tgtctttctt tagagctaat 2310421 gagctttttc gcttctttcg gtctagtcaa aatccaataa tcttttttat cccgttctgt 2310481 tacttttttt gtatcgactt tgatcatgtc agacagcttt tttgcgatct ttaagcgctg 2310541 ttcttgcgtg gtcgatttag atctcgtgta tgtgattgca tttaaagcct tatttgtcac 2310601 aatggcatta aagtttcgat cataaatttt cccgcgtggt accgctgagc tgacttcact 2310661 ttgttcctgc ttattcgctt ggtttttgta atcatcacct tgcacgatct gcttgatgcc 2310721 cagttccaca ataatccagg taaatataac aaaggcagct aaaaataaaa tattcagccg 2310781 gatcggaagc gacttctttt tctctttatg attttgcttt tttggtttat ttctcctcat 2310841 aacatcacct tttctattta cagaaagaaa agacactcaa gtaagagtgc cagttttcat 2310901 tttaaaggtt ttttcgactt ttttctacag ataacccctt tttggcaaaa aaattatctc 2310961 tcgcctttta aaagggtcgg ttctgttacc cgtttttggc cgtcttcttc catggtttca 2311021 ttttcccctt ctttctcctt aaaacgaata tccttgacaa agtaataaat caaaggatgt 2311081 cctataccca atatcgcaag tgacaaagga attcccacat cctctttcag aagggccaca 2311141 atcaggagaa agcacaaaat ggaaacaatt ctgccggcgt tcaagaacat ttctctaagc 2311201 acgatatatt caattcttgc ttttctggca tgcctcgcgc gccctatcac atcatatgta 2311261 agtgatacat atggcacaag caacagagga tagccgatgg caataaaaac gccgtacgtt 2311321 aataatgtcg aaaagctcat atggaacaga atcaaaaaca gcgcgccata caaaataagt 2311381 ccgcccagca aaatcgattt ttttctcgcc tttttcttaa tcagcctgga tgcaaagtag 2311441 taggcaaaga aggaaacagc tgaattgaca agaccgaatg taccgagagc aagctcgctg 2311501 tttgtctcaa taaatacaaa cacactgatt aaaaagacaa aaatcccttc tctcaaaccc 2311561 tgaaaaaaat gcgcattcgt gattctccgc caattcatat tgctatggcg ctctccaaat 2311621 actttgctca gcataaaacg gccctttgat tctctccgtt ttaagaaaaa gctcatcacg 2311681 acagccaggg caaataaact gagggagaga ctgaaaatca ctgtataacc cgtattattt 2311741 tcaagccttg agatcacgaa tccggctaca atcgggccga tcattcctgc agaggaagac 2311801 agaatgccca taaacccgtt gaaaaagtct cgtgtatccg gctctgttat ttcaaaggtc 2311861 agcacgttaa acgctagcca ataaaagcca tagccaactc cgagcaccgc gccgattagc 2311921 acgaggcggc tggccgccgt ttctccggct aaaagcacac ttaaataaaa ggcagctaaa 2311981 aaaatgacgc cgaaccttaa aatgaatacc ctgtctattt ttttggctaa ccgtccagcc 2312041 aaataaaagg ttatcggctg cattgtcaca atggataaat tatatatcgc caaatcaata 2312101 aatttccctg actgcttcca aagatacaca ttaacaaatg tattggacag tgcaattccc 2312161 agcgagtaaa gcccgccaat ggtcagcaga aagagtaagc ctttgtttac gtctacatcg 2312221 cctatcactt tttttagttt gctcattact gactcccctt tactatccct tagtctgtct 2312281 cactcaaacc gagatatgta aaaagaagac ataaaaaaac aaggtcccat aatgaggacc 2312341 ttgtttgtgc cattattttg cttcgctgta tagacgagcc acttcgtccc agtttacaac 2312401 attccagaaa gctgaaatgt aatcaggacg gcggttttga tagttaaggt agtaagcatg 2312461 ctcccaaacg tcaagaccta agataggcgt tttgccttct gaaagcggag aatcttggtt 2312521 tggcgtgctt gtgatttcaa gtttaccgtt gttcacaaca agccatgccc agccagaacc 2312581 gaagcgtcca gctgctgctg ctgcgaattg ctctttgaat ttgtcaaagc ttccaaatac 2312641 actgttaatc tcttcagcaa gcgcgccagt cggttcgcct ccgccgtttg gagataaaag 2312701 tgtccagaat aatttgtggt tcgcgtgtcc gccgccgttg ttgcggactg cagtgcggat 2312761 gttttcagga acagaatcaa gatctgcaac aagctcttca actgatttgt tggcaagagc 2312821 agtgtttcct tcaaccgctt tgtttaaatt tgtcacgtat gtgttgtggt gtttcgtatg 2312881 gtgaatagtc atagtttcct tgtcgatatg cggttctaaa gcatcgtacg cataaggtaa 2312941 ttctggaagt tcgtaagcca tgataattcc tccttagtat atatgtactg aaatgccgct 2313001 tcacagcgag cctttcttca ttcaatgtaa caaaagaatg ctttgtaatc aatgaaaaag 2313061 ctcacgattt ggctcatttc agcggacata tttcacttta accgataatc tgccccatta 2313121 aacctgccgc cagcatttct tataggaccg tccataaaaa gtaaccgatc atcaaaagct 2313181 gtatgatgcc ctttgcaata acccctgtta aaaaaccaat gagtgagccg aggccaattt 2313241 taaacgctga ctttaagtcc ttctgatgga cgataagttc tgcgcaaaca gccccgataa 2313301 acggccccaa tatgatccct gcaaccggaa tgacaaaagg cccgattaat aaaccgatcg 2313361 tgcttcccca tatggcagct ttgcttcctc cgaacctttt tactccaagc agattcgaca 2313421 cgtaatctgc tgcgaataat actgcggcaa aaactgcctc aacaagccag aacatataag 2313481 aatacggact gaatgaaaat aaaaatccgt acaatacaaa tccggcaaca ataaatacta 2313541 cgctaggaat aacaggatac accagcccga taaaggcaat gataaaaacc gctgcaatca 2313601 acagccaata caacatatcc atagcttcca tcctcccatt ttactctgtc ttcttcatgt 2313661 cttccttgta ttcacacgca tgcaacgata caataagcaa catatattag tttagctagg 2313721 aagtgaagat agtgaatgtg tttcagcttt tcattaaaag tacatactct ccccgtgata 2313781 ttgcaaaaac aagatttcaa ggaatcggaa aagcgattct ttatgtattt ttgctctctg 2313841 tcctgtttgc aatccctacc gcttattatg taagtacagg gaccgtaaaa tcaatgaacg 2313901 gctttaaaac tgttttaaac aaagatttcc ctgatttcac aatttcaaac ggcaaacttc 2313961 aaacggatga gaaaaaagcc acggaatctc aggcaaatgg tttcgttatc gtgttcgatc 2314021 cgacagactc ctatggcact gaacaaattg aagcaaagca aaacgcaatc ggcatccttc 2314081 agaacaaatt tgttttggcc attgacggac aagcccaaga aatgtcttac tcaatgatgc 2314141 cgtcagagtt acagaaaaaa gatgtcattg caggtttaaa ccaaaataaa gcgatgattg 2314201 taactgttct ctcagctctt atttttctcg taacagcagc gggaaaattt attgaagtat 2314261 cgtttttagc gcttatcggg ttaatcatta agaattcgca gaaaaaacat ttatcctatc 2314321 atcagctctg gaagctttct gcttattcca tcacactttc aactgtattc tttacaatca 2314381 tgcgggcact agaagcaacc gtaccaagtg aatttttgct gaactggttt gtcaattttg 2314441 tcatcctgtt tctcgtttta aaagagattc cgtccaaaaa agtaattaat aaaagttaaa 2314501 ttatatttat ttttatcctt taagtagaga gtgtgaaagc atttgcatta actttttact 2314561 taagggatat ttaataaaat gtatagagct taaacagata catttataaa aaaagctcta 2314621 caattactca agaacaagct ctggacaata atatcagaag tagtaagatg taacatgaaa 2314681 gaagttctta acagcatttg acatatgttt ttaacaaaat aagaataatg ttaaatttta 2314741 actaatagac tagttaaaat catatggcaa aatattttgc atcctttcac aacatattta 2314801 cataagatag ttgctattta aaaagccagg taccaatagg gcacctagct ttcagaatta 2314861 aatcatcaac aagttagaat tatcttcttt ccttctattc tcattattga actgttatct 2314921 tttttgtggg tttatgtata caaatgcagc tcccttagct ttccccttat atactgataa 2314981 acctactgcc caaggtgttc ctgtcggttt tggtaattta ctgaagtaaa actttttggt 2315041 tggagttcta cttgaaaagt accctgaata ttgcgggcca atgtccccac cctcaactat 2315101 agatacacca aagctcttat aatttagttt accgcatttt ccatttgttt cggcgtaagc 2315161 atcaatagat gttgcactct tagtatatgt ataagcatct gtaataactc ttattttaca 2315221 accagaaata ccacttaccg gttgccaacc actgcttgca gcctctgctt tttctttagg 2315281 tgcaactacc aaagttaaca ttagtagcaa aattaaaaac acagaaaatt ttccttgctt 2315341 cattttgtag atcctccttt aaactattac ataattatcc taacagatcc attgttcatt 2315401 gtaaataatg gaatacgagt tttatattat aaaagcctct ttttgatcta attttgcact 2315461 attttctatt ttctatctga agttaatgtt tagtcgaaga aatcctgtca aaaaagcgcc 2315521 tgtataaaaa ccgagcattc gcagtctctt ttcttttgtc atgaatcgaa atggacaagc 2315581 atactatggt ataaaatttc gtatgcggga ggaaaagcga tgaagcgtct caccttagta 2315641 tgcagcattg tttttatact ttttattctt ttttatgacc ttaaaattgg aaccataccc 2315701 attcaggacc tccctgtcta tgaagcatca gcaaaaacgg ctgtacaaga accggcttat 2315761 aaaacggtga aggtaaagcc gggtgatacg gttatgtcga tagtcggatc agcaggttct 2315821 ccggatgaca ttgtaaagga ttttgaagca ctgaatccaa atgtgaaagc taacgccatt 2315881 caagccggaa cagcgtataa attcccggtc tacccttaat ttaacgttaa tttcttgtca 2315941 gttcggcgaa gacactgtta caatgtaatt tgtaaaataa attcacataa accatactag 2316001 aattgttata tctagaagcg gcaactacaa ttaaggagcg attgcaagtg agtgaaatca 2316061 cacatcgtac aaaaacgcgt cccgtcaaag tgggaccttt aacaataggc ggcaacaatg 2316121 aagttgtcat ccaaagcatg acaacaacaa aaacacatga tgtagaagca acggttgcgg 2316181 aaattaaccg tttggctgaa gccggatgcc aaatcgttcg ggtagcatgt ccggatgaac 2316241 gggcggcaaa cgccattgcg gatattaaaa agcgcatttc cattcctctc gttgttgaca 2316301 tacatttcga ttataaactt gcgttgaaag ccattgaagg cggcgcagat aaaatccgaa 2316361 tcaaccccgg caatatcggc cggcgcgaaa aagttgaagc ggttgttaaa gcggccaaag 2316421 acaaaggcat tccgatcaga atcggagtaa acgccggttc attggaaaaa cggattttag 2316481 aaaaatacgg ttatccgact gccgatggaa tggtagaaag cgcacttcat cacattaaaa 2316541 ttcttgagga tcttgatttt cacgatatta ttgtcagcat gaaggcctct gacgtgaacc 2316601 ttgcaatcga ggcttatgaa aaagcagcga aagcgtttga ctacccgctt cacctcggga 2316661 tcaccgagtc aggaacactg tttgccggca cagtaaagag cgcagcagga ctcggcgcca 2316721 ttttaagcaa aggcatcggg aacaccatgc gcatttcact aagcgcagac cctgtagaag 2316781 aggtaaaagt agcaagggag cttctgaaat ctttcggctt agcctccaat gctgccacgc 2316841 tcatctcatg cccgacttgc ggccgtattg agattgatct aatcagcatt gccaatgaag 2316901 tggaagagta tatttctaag ataaaagcgc cgattaaagt tgctgttctc ggctgcgctg 2316961 taaacggacc tggtgaagcg agagaagctg atatcggaat cgccggcgca cgcggtgaag 2317021 ggctgctgtt ccggaaaggg aaaattgtcc gtaaggttcc agaggaaacg atggtagaag 2317081 aactcaaaaa agaaattgac attcttgctg aggaacacta cgcaaaactt gaagctgaaa 2317141 aagcaaaatt aaaagaagaa acacaaaaag cttgacggga acccgtcaag cttttttgtg 2317201 ttagaaaaat ggaataataa atattccaag cactaatgaa acgacaccga tacccattgc 2317261 ccaggctcca aggccttgag cacctcttct tcttgcgata tagccgacaa taataccagc 2317321 agctcccaat aaaacaggca gtacaaacaa tgaaatgatg gacaaggcta aagcgatgta 2317381 ccctattccc cgtccttcat tgacattgcc gccgctgcga tcattgtctt ggtcattgct 2317441 gcggtcagca gcacgataag gctctgcgat ttcagcagct gtttcctcaa aaaaaccgtc 2317501 attgtcgcgg gtaatatttg tcccttcaga tccatgatca acatagtaac tgttgttatc 2317561 acgcttttcg taatcgtttg ccaccttcaa ttcccccttc tgttttatta aaggagcttt 2317621 tatagtttga tccattttgc ctgattcatg tttgctaaac ttttctgtta atgtcaattg 2317681 tttatgttac acttgaaggg atgaaactga aggagtgtgg gcatgttacg cttaggaata 2317741 gatattgacg gcacaatcac ggctcaggat acattcgtcc cttatttgaa ccgttcgttt 2317801 aatctttcca tttcattaaa cgatatgacg gattatgatt taacaaagct gttaaacatt 2317861 acccaggaag aattttggga ttggatgaat caaaatgaag cgatcatata taaggaagca 2317921 ttgcttgcac agcatgcgaa acagtctctc gatcttctca aagaggagca caagcttatt 2317981 tatattacag cgagacggac tcatttaact gatattactt atgaatggtt tgacagacaa 2318041 aacattcatt atgaccacat cgaacttgtt gggggtcatc acaaagttga agcggtcaag 2318101 aatcataaca tcgacctgtt ttttgaggat catcacggga acgccatgat gattgcgaaa 2318161 gaagccggga taccggtgat tttgttcaat tccccttata atcagcttcc gattgattca 2318221 aacatcatca gagtaaacaa ctggctagaa gccgttcaat ggatgaacaa caacaagcat 2318281 cacttaatac gcgtcaataa ctgaaaaagg agcccaaacc gggccccttt ttcatatata 2318341 cgcattttac gcagtagtgt tttcttggtt ttccgctgta caatcagggc atgtgccata 2318401 aatctcaaat ttatgcccgc tgacctgata gccatccaaa tcatcacaaa gcttgtccat 2318461 cggacatgat tcaatttcct ttgttttgcc gcaggcaaga caaataaaat gatggtggtg 2318521 atgggtgaat gaacacttaa atcggaagag cttttcaccg gacagctcag ttgtttccaa 2318581 aatcccaagt tcttcatata aagaaagatt tctgtagatt gtatcaaagc ttaagcctgg 2318641 ataatcatca ttcagtgcag acagtacgtt tttagcggta agatatctgt ctgaatcagc 2318701 aaaaagctgc agcatatcct cccgtttgtt tgtatattta tatccgtttt cttttaatag 2318761 gttcagcgct tcttggacgt tcatgaaggg tccccctttt cgctttgctt aagaacgtat 2318821 cacatgtatg aaaaagaaaa tggcagctgt ctgtccagca agccattttc tttactgcag 2318881 ataaaattat acccataaaa tgaataaaag taaatgaaag cctagtggat tgcgtttttg 2318941 aattttccgc ctctcgtttc atgagtattc ataattgtta tgaatgcatt ttgatcaact 2319001 tcaaacacga tcgatttgag ctttgtcact tccagccttg tgacaaccgc gtaaattacg 2319061 tctttttctt cgtccgtata cccgcctttc cccttcagct tcgttgtgcc ccgaccgaga 2319121 cggtgcaaaa tcgcgtcgga aatctcatca tactgctcag acacaataat gacagctttt 2319181 gtttcatcaa gcccttggat cacggcatca atcgttttca tcgcaatata ataagtcatg 2319241 aatgagtaca tcgcttgctc aggaccgaac acaaaaactg cccaaatgaa aatgaacaca 2319301 ttgatgaaca taacgaactc acctacagaa aacgggagtt ttttggtcag caaaataccg 2319361 agaatttctg taccatccat tgaacctcca tttcgaataa caagcccgac gccaaagccg 2319421 agtaaaagac ctccgaacac agtagccaaa ataggctggg ttgtaatggc ttctacatgg 2319481 tgaagtgagg attcaataac ggcaagcccg acaatcccta taaacgtaga gactagaaag 2319541 gtcttaccga tatatttata tccgaagatc ataaaaggaa tatttaatat gacaacgaaa 2319601 aaagcgaaat tcagaaaggg gtttgacata aagaggtggt ctaaaataag agatacaccg 2319661 ataatcccgc catcaataaa atcattgggg attaaaaata attcaatact tacagccgca 2319721 gatgcagctc ctaccagaat cataaagacc ctgaaaataa aatgggtaaa tgtttctttc 2319781 ttatgttgtt ttgttggggt cataaaatct cctttcctgc aataactatt ttaaatacat 2319841 tataaatcta ttttaccatt aaacactgac acattttact gatttgccca tacattaagt 2319901 ctggaggtgg aatgaccgat gattttattt caaagaatta ttttgcagcg gcttaatcag 2319961 gctactgctg atgatttgct gaagtactca aaacaatacg gaatcagctt aacaagatcg 2320021 caggccgttg aagtagcgaa cctgttatac gggaaaaatg taaacatctt taatgagagt 2320081 gaacgaatgc ggctgctgaa acaagtagag acgattacat cgaaagaaac agctcaaaca 2320141 gttaatgaac tattcaaaca atttacaagc taaaaaatgg gggtgttatc ccccattttt 2320201 tattgctgta aaatcttttc aagcaatgta tcatcaaatt gtttttcttt cagcatttca 2320261 atctcaaaac ggtatggcgg ttttttgttc tttttatctt caccgacgta tggtgtttca 2320321 agaatttttg gaatgtcttt taactgctca tggtgaacaa catattgcag tgcgtcaaaa 2320381 cctatttcac caaagccaat attttcatgg cggtcttttc tcgcaccttt gacatttttg 2320441 ctgtcattga tatgaagcac tttaatacgg tcaatgccaa tgattttatc gaactcattt 2320501 agcactccgt caaagtcttc gacaatgtta tacccggcat catgtgtatg gcacgtgtca 2320561 aagcacactg acagctgctc attgtgtgta acgccttcga taatctgcgc aagctcctca 2320621 aagcttctgc cgcattctga tccttttcca gccattgttt ctaatgcaat ctggacattt 2320681 tgattcggat caatcacttc atttaagcct tcaataattt ttttgatgcc ggcttcagct 2320741 cctgccccta cgtgagcgcc aggatgaagg acaatttgct tcgctccgat ggccgctgtc 2320801 cgttcaattt ctgaacgaag aaaatcaaca cccagctcaa aagtggacgg atttgtcgtg 2320861 ttgccaatat taataatata aggcgcgtgt acgataatct cgtcaatgcc gttttcttgc 2320921 atatgtgccc ggcctgcttc tatatttaag tcttcaattt tctttcggcg cgtattttgc 2320981 ggtgcgcctg tatagatcat aaacgtattc gccccataag agactgcttc ctggcttgca 2321041 gccagaagca tatgttttcc gctcatagag acgtgtgagc ctattctcag caacaggttc 2321101 ccctactttc ttttcttaga ttggtttctt ctctgttttt tcttgatttt ctccatctca 2321161 tagctcattt tctttttata cccaggctta accttcttcg gctttttcac gagacgatga 2321221 gcaatttcat ccgcttcatt cggcgttttt ttacgttttt tgcggcgctg acggtcatcg 2321281 ccttttttcc attcgccctt ttcaagctct aagtactcaa attcgatgcc cattttttca 2321341 agtcttacta atgcatcctc atcagtaagc tcataaatgg tcatcgcttg tcctgatgag 2321401 ccggcacgag ccgttctgcc cacacggtga acatagaaat cgagatcatc cggcagctca 2321461 tagttgataa catggctgac acctttaata tcaatacctc ttgcggcaag gtcagttgca 2321521 atgatatatg tgaattccaa atcattgatc tgcttcatga cttttttccg ctcacgtggt 2321581 gttaatccgc cgtgcagcaa gccgattttc atgcctttgc cagtcagata ctgggcaata 2321641 tggtcagccg tatttttcgt gttggcaaac acaatcccca ggtatggatt cagatgcgac 2321701 atgatgtcaa aaaggagctt gtccttgtca cgatgtttcg aaggaatgag gatatgctcg 2321761 attttcgcag cagtcacctg ttttggctcc acatgggcgt atttcggatt ttccatgtat 2321821 ttcttcaaga atggtttcag cttttccggt atggtcgctg agaacacaag catttgcaga 2321881 tcctcaggca tgcgggaacc gatgtaatct acatctgcaa ggaatcccat gtccagcatt 2321941 aaatccgctt catcaataac aagagattcc gctttatgaa cacttaacgc ctgttctttg 2322001 attaagtcag caatccgtcc aggtgtaccg acaacaagat gcggctgtat tttcaattta 2322061 tcaattgatt tttgtttatc agtgcctccg ataaaacatt tcgagcgaat ctgacttcct 2322121 tcttcaccct gcgtgatttt aagcgcttcc tgataaatct ggttggcaag ctctcttgtc 2322181 ggagccgtaa tgactacctg aacgacatcc ttagcaggat cgattttgtt taataaaggc 2322241 agtaaataag cgtgagtctt tccagtaccc gtctgagact ggccgatgac gctttctttt 2322301 tttaacactg caggaatcag ccttttctgg atatcagtcg gttcgtaaaa accaaggcga 2322361 tgtactgcat ctataataaa tggtttcaat tcataaagtt caaatttcgt ttctttcatt 2322421 tttcccagct ccttaaagcg gcacattatg tgtccatcat cacattatac ccgattttgc 2322481 ttaaaaacac cacgtttgca aggcgtttgt tttattcagt tatgtaaagc aaataccgca 2322541 gcccatgcat attctaatag cagagagagc tgaaaggagg tacaagtatg ttttcaccgc 2322601 agcagccaat gagaaattac ccacagcccg gaccgccccg ccccatgcca aatcagcgaa 2322661 tgatgggcag aagaccgcct aatatgcgag gaccttcatt tggagcacag cagcaaggtt 2322721 ttcagcaagc cggacaattt cttcctcagg caaatgccgg agcgagaaat ggtgcaggtg 2322781 caggcggagg cttaaaagga atgctgtcaa ggttcctccc cggcggagga ggcgctggca 2322841 gcgccggggt tcccggaatt ccaggagcag gtgcagcagc gagcggaggt gctggcctgc 2322901 aaggcattca aaatattgcc aatcctgcat cattatccag tatgcttgga aatgtgcaaa 2322961 aagtactcgg catggcgcag caagtcaccc ctatgatcca gcagtacggc ccattagtcc 2323021 gcaatctgcc agcaatgatg aagctgtaca gccaattaag taaaagtgat gatactgaga 2323081 cagaggccaa tgaggaaagt gaaaaacaat ccgtttcaga agaatcatca gaaaaagaaa 2323141 aagagactga aacaaaaacc tcagatggga acaaaaaatc aaaaccaaaa agttcttctc 2323201 tcccaaagaa atctaaaaca actgacaata aagaacaaga attaaaaaca tctgccccga 2323261 agaaaaagga agctgcctct cctgctccga aaagaacatc aggcagttca aaaccgagat 2323321 tatatattta acattctttg atatcttaag tgagattggc tataatgaga tcagaagaat 2323381 gcaagaatag agccgtttga ttacggcttt ttatattgcc tttactcact tcagtattgg 2323441 aggacaaccg aaaatggacg taattaaaat ttcaccgcgc ggctattgct atggtgttgt 2323501 tgatgctatg gtcattgcca aaaatgcgtc gctagataaa agcttgccaa gacccatcta 2323561 tatactcggg atgattgttc ataataaaca cgtcactgat gcgtttgaag aggaagggat 2323621 ttttacattg gacggctcta accgtctgga catcttaaag caggttgaca aaggaactgt 2323681 cattttcact gcgcacggtg tttctcccga agtcagaaga atcgcagaag aaaaagggtt 2323741 agtcgcaatt gatgctacat gtccggatgt gacaaaaact cataatctaa tcttagagat 2323801 gaaagaaaaa ggatatcacg tgatctatat cggcaaaaaa gggcatccag agcctgaggg 2323861 agccgttggc gtagcgccgg agatcgttca cttagttgaa acagaagaag atgtaaagaa 2323921 ccttgatatc caatctgaga agttaatcgt gacgaatcaa acaacaatgt ctcaatggga 2323981 tgttcacgac attatggagc ttgtcaaaga aaaatatcct catgtcgaat atcaccaaga 2324041 gatttgcctc gctactcaag tgcggcagga agctgtatca gagcaggcaa aaaaagcgga 2324101 cttaacaatc gttgtcggag acccgaaaag caacaattca aataggcttg ctcaagtgtc 2324161 agaggaaata gccgggacaa aagcataccg gatcggcgac ttaagcgaat tgaagctcga 2324221 atggctgaaa ggcgttaata ccgttgcagt tacagcggga gcttcaacac cgacgccgat 2324281 cacaaaagaa gtcattcgct ttttagagca gtttgatcac gaagatccat caacttggac 2324341 aactgaacat aatataccgc tcaaaaaaat acttccaaaa gtaaaagcaa aaaactgagg 2324401 ctgtaaaagc ctcagttttt ttatagaaat gtaaatggat ttgtatctgt ttcagaaaca 2324461 aagatattca cgccaaactt tttatcatta cacattgatg taagttttct cgtgacgcct 2324521 tctttcatga ttttttccgc gtaatggccc ggatcaacca catttaggcc aagcatcatc 2324581 gcatcatggg ccacatggaa gtataaatct cctgtgacgt aaacatcggc tccctttcgt 2324641 tttgcatgat gaatatactt gtttccatct ccgccaagaa cagctacttt tttcaccatg 2324701 ctgtcagcat ccccaaccat tctgacacca ttgacgtcaa gcttgtcttt cacaaataaa 2324761 gcgaattcct tgagcgtcat ctcattttta agggttccga cacggccgag ccctttttcg 2324821 gcgggagtct gttcgacagg atagatatcg taagcgactt cttcatatgg atggcttttt 2324881 atcattgcat tgataacagc cttttcgacg cttttaggaa atacagtctc aagccttact 2324941 tcatgaacaa gctcaagctc tcccacttca ccgataaaag gcttagctcc gtccaatggc 2325001 ttaaagctgc cgattccttc agatgaaaac gcgcaatggc tgtattcacc gatatggccg 2325061 gcccccgcat ttccgagcgc ggctctgacc tgctcttcat attccttcgg cacgtaaact 2325121 gccagctttt tcagaggatc cgtataagta ggtgccagca cttccgtctc actcagctct 2325181 aatgcttcag caagcaaatc attcacaccg ccgtccgcaa cgtctaaatt tgtatgagct 2325241 gcataaacag caatatcatg cttcaaacac ttttcaatta accttccggc aggctgatct 2325301 gttgaaatat gctttagcga ccggaaaatt ggtggatggt gtgcaataat caagtcaacc 2325361 tctttttcaa tcgcttcatc gataacgctc tctaacacat caagtgtaac catcacattt 2325421 ttaattggtt tgtttaaggt gccgatttgc aggccgattt tatctccttc aaccgcatag 2325481 gctttcgggg aaaattgttc aaacagctgg atgatctgct gcccatttac acttttagcc 2325541 atgatcgatt acctccttta acagctccat tcgatcggcg agctccttta atttttgttt 2325601 gttttgctct gtatccgccg cttggctgat ctgttcataa atgctttgag tgtgctgaag 2325661 ctcttgtgtc cactttttca aaaagacagc atttttttct tttgccaaga aagggccaac 2325721 gagcatcccg gctgataaag aaataccgtc ataagccgca tccctgtctc ccgcttctgc 2325781 caccagcacc tcatagcact ttccgtcctc ttcaaggatt acctcatcta tcagcgcata 2325841 tctttcttta taaagccact ccctgatatg aacagcatga atattcggct gtaaaatgag 2325901 ccgttccttc cccgttaatt tgtctttgcc cgcttctaaa atgtgagcga tcaaagcccc 2325961 gcccattccg gcaatcgtaa tggcatcagc ttcacctttt ttaatcactt ccagtccgtc 2326021 tccctgcctt acagaaatgt gcgagtttaa gcctgatttt tcaacctgcc gctttgcaga 2326081 caaaaatggg ccgtctgtta tttctccggc aatcgccccg ctggctttat gattcagcac 2326141 cgcataacaa ggaaggtagg cgtggtcaga gccgatatcg gccatcaccg ctccattcgg 2326201 tatgtactcc gctactgttt gcaatcgttt agataatttt aattcgttca cttgtcatca 2326261 caacttttct caatcatttt ttcctttact atcatataaa aaatcagccc ggaatccaag 2326321 ctgaagcaaa tgattttgaa attatttctt ttgatgcggg tctgcacgca gcagtcaaaa 2326381 ataaaaggct gtcgagaaca tctcggcggc ctgtgaatgt ataaagagaa aaatagttct 2326441 tttatttaat ttttgacacc cactctgcca tatcatccag cttatcggcc ggaacaagac 2326501 cggaaggcat tccattaccg cctttttcga tctttgtttt aatttcagcg acatctttct 2326561 tatcccctac accttttaag ctaggacccg aaacaccttc ataattttca ccgtggcatg 2326621 cgatgcagtt tgccttgtaa atttcttctg gtgaagcgtt tgcatctttc ttttcagcag 2326681 atttgctttc tcctccgctc gcaatctccc gagagtcatc aagtcctttt actgataaaa 2326741 agaaagttag accaattcct aaaacagcga tcagcaaaaa tggaataagc gggttccatt 2326801 tcatttccct tccccctttt tgatccttcc ccctatgtaa acacttctaa ttctaactta 2326861 tttttacaaa aagtaaatgg attgctatac aaaagttttt tattcacact ttatacaaaa 2326921 ttgaatagaa acatgcctaa atctctaata tcctttttat tctattgtat aatgtattgt 2326981 atacgcttac aatagaaaat atggaattag attttgaaat ttttcaccac aatgttcatt 2327041 tgcaaatgac atcatttttc agtaaaataa aggcatatta tccatatatc tttttaaaaa 2327101 aagaagaacg gatcttcaag acccgttcca tcttattcaa ggaaatcttt caaacgttta 2327161 cttctgctag gatgtcttag tttccgcaac gctttggctt cgatttgtcg aatacgctct 2327221 ctcgttactc caaatacttt gccgacctct tctaatgttc ttgtacggcc gtcatcaaga 2327281 ccgaatcgaa gacgcaatac attttcttca cgatcagtta acgtatcaag cacatcttcc 2327341 agctgctctt tcaatagctc gtatgcggcg tggtcagaag gtgaagttgc ttcttggtct 2327401 tcaatgaaat caccaaggtg cgagtcatcc tcttcaccga tcggtgtttc cagagatacc 2327461 ggctcttgag caatctttaa gatttcgcgt actttttcag gcgttaaatc catatcttcc 2327521 gcaatttctt caggtgttgg ttctctgcct aagtcttgca gtaattgacg ctgcacacgg 2327581 attaatttat taatggtttc aaccatatga acgggaatcc ggatcgttct cgcctgatcg 2327641 gcaatggcgc gtgtaatcgc ctgtctgatc caccacgtag catacgtact gaatttataa 2327701 cctttgcgat aatcaaattt ttcaacggct ttcatcaggc ccatgtttcc ttcctggatc 2327761 agatcaagga acagcatacc gcgtccgaca taccgttttg cgatactgac aacaagccgc 2327821 aggttcgctt cagccaatct gcgtttagat tcttcgtcac cttcttcaat cttttgagcg 2327881 taggcgattt cttcttttgc agaaagaagg ttaacccgac cgatttcctt taaatacata 2327941 cgaactgggt cattgatttt aacgccaggc ggtacactta ggtcattaag gtcaaattct 2328001 tcttcggctt tggcaagctg ctgaatatta ggatcttctg tttcttcatt ctcactaatt 2328061 aattcaacac cttgttcacc taaaaattca taatactcat ccatttggtc tgattcaatt 2328121 tcaaagctgg acatacgctc agcaatttct tcatatgtca aaacgccacg ttttttacca 2328181 gactctgtta attgctcttt tacttggtcg aatgttaatt ctgtctcgtg ggtttgttta 2328241 tcagccatta tggatccctc cttccaaagc ttgcaacgaa ttctataagc ggtatgattc 2328301 ttattcggtc cattcaggcg ttttctatgt gaactgcctt taacaatgtg cgaataatga 2328361 aatgacaatt catgatgagg ttaagcgatc tatttgctcc tccgcaagga atcattgcca 2328421 ataaatgctc ctcatcagtt ctccagttat tttaaagatc ggttcaatgt aacgatttct 2328481 tgagccaaag aagcagctct taaaaaatct ttttgccttt ctgcttcggc tctttccgcc 2328541 tctttttctt ttatcattga ccaatttctt tgattcaaca ctttttttac ataatctgat 2328601 aactcggctt cgctaagctc ttgattaacc tgaagcatta atatatcgga caagagctgg 2328661 cttatatgat catccgtcac cctggccatc agatgctgag gcgtcagctc ggctccctct 2328721 tcataaaaag cataaagata agcggctaat gcccggtgct catcaatatt aaattgaaac 2328781 cctacccggt caatcacttt tttgatgacg ctccgatctc gaagcatgtg agcgagtaac 2328841 agcctttctg cattttcata cgccggacgc aaacgttttt gccttgcttt tgtcgtcaga 2328901 tgcgctcgcc gcgttttagt ttcaccgcta ttgtcagcag gtttgttttg cttgctgaaa 2328961 acagacagct gctcagttaa agactcctgt gaaagcgaaa actctgaagc aagctgcttt 2329021 acatagactt cctgctctag agaccctgaa agcgtgctga tttctttcag tacgtcttta 2329081 atgtaagcta ggcggtcgcc ttcatcggac aggttctttc cttttcggaa atattgcatt 2329141 ttgaacgcca ttacggtgac acttgcgtca ataatgtcgt ttttaaattt ttccccgccg 2329201 aattttttga tgtaatcatc agggtccaat ccgtcaggaa tcattgcaac tctgactttg 2329261 cagccttttt tttgcagaag ctccgaagct tttaaggtgg cttcataacc ggctttatca 2329321 gagtcatagc aaagaatgat ttcttcgacg tttcttctca ggatcttgac atgatcatct 2329381 gtaagagacg ttcccatcgt ggctatgctt tcctttacat ccgagcttac ggccgatatg 2329441 acatcagcaa acccttcaaa taagactgct ctttcctgct ttctgatatg aaggcgggcc 2329501 ttataaaaat tgtaaagcag tttgctttta tgaaagagcg gggtttcagg actgttcata 2329561 tacttaggct gctggctgcc aagagccctg cctgagaaag caacaacagc cccgtgatga 2329621 tcatggatcg gaaacatgac acggtttctg aagcggtcga aatatccgct tccgtcttcg 2329681 cgtctgatca ggagacccgc tttttccatt tgcgcctcac taaatcccct ctttacaagg 2329741 aatttcgtga taaagtccca agaatcaaga gcatagccaa tctgaaattc attaatcagc 2329801 tctttcgtaa agcccctaga aagcagataa tccagtgcct cttgaccttc ttttgtattt 2329861 attaacaaat gatggtaaaa tttcttcagg agctcatgtg cctcagccat tttttgttct 2329921 ccagaagact ctggccgggc tccggaatgg actgttatat catctggaaa atcaatttgg 2329981 tatttgtcag caaggtgaga aaccgactcg gcaaaagaat agccttccat ctgccttaaa 2330041 aaagagaaaa cattgccgcc cgctccgcag ccaaagcaat gaaaaatctg tttgtcgggc 2330101 gatacggaaa acgaaggtgt gctttctcca tgaaaaggac agagtccaaa gtagtttcgg 2330161 ccttgcttct ttaattgaac ataatcacct atgacttcaa cgatatctgc cgacttttgc 2330221 acctgatcca caatttcatc tggtatccga tttcccatct tataacactc cgtcgtacat 2330281 tattcgatgc tttagtgcaa aatcccttca tcgttcgaca ggattttttg cagcagtgta 2330341 ataaatcgtt ctcgatcttc tttattcaat tttttaggcc ctttggcata tacgcctttt 2330401 cttctttgtt tgccggaaaa atgacggccc tctagggcaa aatcaatcgt gtcttccttg 2330461 taaagacgac ctctttccga cataacagag acatttctgt tcaacagcag agatgctaat 2330521 ccgatgtcct gcgtcacaac aatatctccc ggtttcacgt gatttgcgat atataaatca 2330581 gcagcttctt tatgaggatc aacatacttc catttttctt cattgcttct ggaaagctga 2330641 taatgttcaa atgaagcgac aaaaagaact tgaacttcat actcggatgc tgtttgtaaa 2330701 atttcatctt ttaccggaca agcatcagca tcgacaaaaa tcgtcttttc ttgttcatta 2330761 agaagagtaa ttctccatcc ctccattaaa ctcctgcata aaagcaagca aaatcgcaca 2330821 tcctttatta ttgtggatgt atatgaattt gtcgaaaaat ttccgggaga aattcttgac 2330881 atcttaccca taatagttta ttcgtatcac acgatcctta aacctaaaat taatcatttt 2330941 atcacaattt tttattataa tacaaacttc acaaagatgc tattgttttt cattattccc 2331001 ttttggcaca gccaaaaacc caggatagag cgtcctgagt tatatgtttt ttgttttgag 2331061 atgatggata atatttgctg tttcctcaac cgctttattt gaaacatcaa caacctggca 2331121 gccgatccga tccacaatct tttcgaaata ctcgagttcc tctttgattc tgttgatatt 2331181 tgcataaatc gctttatcat taagcccgag tgattttaaa cgttcttttc tgatatgatt 2331241 cagtttatca gggctaatct ttaaaccgat gcattttttc ggatcaacgt taaagagttc 2331301 ttccggcgga tcaacctccg gtacaatcgg aacattggca accttcaggc gtttgtgtgc 2331361 gagatattga gacagcggtg ttttagacgt tcttgacacg ccgatcaaaa cgatatcagc 2331421 ttttaaaatc cctcttggat cacgtccatc atcgtattta actgcaaact cgatggcctc 2331481 cacttttttg aaataatctt catcaagctg gcgcacccgc cccggttcgt atttcgctgt 2331541 taaaccgtag gctgtttcca ttttatcaat caacgggccg ataatatcat aatataaaac 2331601 atttgctttt tccgcttcgg ctatcaaata ttctctgatt tccggcacca cgagtgtaaa 2331661 acagataatg ccgccgtctg cctttgcaag tgaaatcact tcattgatag tgcctatatc 2331721 ttcaacataa ggaattcttc ttacatgagt atcatccgcc gatccgttaa attggctgag 2331781 tgctgctttt actaccaatt cagccgtttc accgacggaa tccgatacaa catagatgat 2331841 gcggttattc atattatccc cccgttagtt tgcaatctta taggatttca ttttcagata 2331901 aactgacaag tattttggtc atatttgttt ttgtcactct gccgatcact tcaaagcctt 2331961 tatcggtgtc tttgatgaca ggcagtgcat caatttgttt ttctattaag tgctttgcaa 2332021 tgtccatcac ataatcctcg cgtctgcaca ccgtaatgtt cggcatcctt gtcatgatga 2332081 tgtgaacagg gaccgatgta agctcctgct ggccaatgct cgctctgagc aagtcttttc 2332141 gtgaaagcac cccgactaaa acagcatcgc ggtccaccac aaacagagta cctacatctt 2332201 ctaaaaacat ggtgcaaatc gcatcgtaca cagaaacgtt ttcgtgaatc actacgggga 2332261 tagattgaaa gtctttcacc tgaagctttt tgagtttatc cgccaaaagc tgtgtgccgg 2332321 tttttcccgt atagaaataa ccgactctcg ggcgcgcctc gaggaatcct gacatggtga 2332381 gtatggctaa atccgggcgc aatgtcgccc tggttaggtt cagcttttct gcaatatgct 2332441 cccctgtaat cggcccgttt tcttttacaa tctgcaaaat atgttcttgc cgtttattta 2332501 gttcgatcgt actcaccacc ttttcacttc atagctatgt aaagaaataa caatccatat 2332561 tataacgtaa atatcttgta atcaaacaaa aaacttataa atggggaaaa gacgattacc 2332621 gatcacacag caaccgcctt ttctctcttt attttacaat aagggcattc atattcgcaa 2332681 aggacttgat ctcatccgcc aagcttacca tttgcgctaa acgatttgcc tttaatgact 2332741 cattatccgc tataaccatt gtatgatcga agtaagcatc gatcggttct tttaaggctg 2332801 caagtgaagc aagcgccgcc tcataatctt ttttgctgaa gttttcctgc agattttgct 2332861 tcgctgtttg gtaggcatca aacagttttg cttcgtattc attttcaaac agatcaggct 2332921 gaatgtctcc gcggactcct tttttgctga tagagatcac tcggcctaac gcttcggctg 2332981 tttccttaaa gccaggtgca ccaagctttt gctccagtac ttgtgcttta tgcagcgcag 2333041 agtacggctc aagctcagag ctttccagca cggcgtcaat gacatcatgt ctgatttgtt 2333101 cagcattcaa gacatatttc aagcgctgag tgaagaaatc cagcagttca ttttctttat 2333161 cggtttgaac gaaagtaagc agctcttcaa atgaaattcc ccagttgcgg tcaagaagaa 2333221 tcgcaacaat accgcttgct tggcggcgca gtccgtaagg gtcctgggaa ccggtcggaa 2333281 ttacgccgat agagaagaat gaagcgattg tgtcaagctt atccgccatt gctacaacag 2333341 ctccggtgaa agtagaaggc gtttctccgc ccgctgatct aggcatataa tgttcattaa 2333401 ctgccgcagc cacagcttca tcttcgccaa gcattctcgc atacttttcg cccataattc 2333461 cttgaagttc agggaattca tatatcatat gcgtcacaag gtcgaattta gaaatttcag 2333521 cagcccgctt cacatgtttt aatgtatctt catcagcctg aagacgaacg gcaagtttct 2333581 ctgcgattga tgtgactctc ctaaccttat cagcaagaga accaagctct tcatggaaaa 2333641 cgatattttc aagcttcttc acatttgcat caatgtttag tttctgatct tctttgtaga 2333701 agaatgaagc atcagataaa cgtgcgcgca gcactttttc attgcctcgg gccacatttt 2333761 caatcgcgtg gctgttgccg tttcggactg tgataaagtg aggcagcagg tcaccgtttt 2333821 tgtctttgac agggaagtag cgctgatgct ctttcattgt cgtgacaagc acttcttcag 2333881 gaattgacag aaactcggat tcaaatgaac cgtaaagagc tgtcgggtat tctactaaat 2333941 gattcacttc atcaagaagg tcttcgtcaa ctggaatgct ccaattgttt tcagcagcca 2334001 ttgtttccag ctgagattga atcatttgct ttcggacgct aggatcagca ataacatgct 2334061 gtcctttgag ctgctcttca taagctgaag gtgattcaat tgacacttca tgtccgagga 2334121 aacggtgtcc ctgtgttgtc cgtccagact caacgtttgt gatcgaaaat ggaatgacat 2334181 cctgtccaaa taatgcgaca atccatttga tcggtcggat ataacgcaaa tcttcatttc 2334241 cccagcgcat gtttttcggg aaatgcaagc ttgtaattaa accgctcaat tctggcagaa 2334301 gcgacttcgt ttcttggccg gcttggaatt tttgcacgaa tacatactct atgcctttta 2334361 cttctttgat gtacaggtct tccacatttg cgccttggcc ttttgaaaag ccgattgccg 2334421 cttttgtcca gttcccgtcc gcatcaaggg caattttttt cgcaggccct tttgcttctt 2334481 cttttatatc atcctgcttt tctgcgacat ccttaacgaa cacagcaaga cgtctcggtg 2334541 tattgaagag tttcacttca ccgtgagtaa tatttttttc tttaagccag cctgtcagct 2334601 tgtcgccaag ctgaaccatg ctttcattca aaaagcgcgc cggcatttcc tctaatccga 2334661 tctctaaaag taaatcctgt ttactcatga gaagaaccct cccctttaag cattgggaac 2334721 cctagttttt ctcgttcctc atagtaggtt tttgctactt ttctagctaa attccgcact 2334781 cttgcgatat agcccgtccg ctcggtaaca gagatcgcac ctttggcatc aagcaggttg 2334841 aaagtgtgcg agcatttcag cacatagtca tatgctggat gaacaagtcc gttgtccatt 2334901 tgcttgatcg cttctttttc atatgtgctg aacaattgga acagcatatc gacgtctgat 2334961 gtttcaaacg tataaacaga atgctcatat tcagccatca tgaataaatc ttttactgta 2335021 aaccctgacg tccattccaa gtcaaacacg ttttctttat cctggatata agacgcgaga 2335081 cgctcaattc catacgtaat ctctacagaa acgggtttac actctaatcc cccgacctgc 2335141 tggaaatacg taaattgtgt tatttccatt ccgtcaagcc aaacttccca gcctagaccc 2335201 gcgcagccta aagacggatt ctcccagttg tcttcaacaa agcgaatatc gtgctcaagc 2335261 ggatcaattc caagagcacg caaggaatcc aaatacagct cttgaatgtt atcaggtgac 2335321 ggtttaataa tgacctggaa ctgatgatgc tgatacagtc tgttcgggtt ctccccgtag 2335381 cggccgtctg ccggacgtct ggaaggctct acataagcca ctttccacgg ctcaggaccg 2335441 atactgcgca aaaatgtata cgggctcatc gtgccggctc ctttttctac atcgtaagcc 2335501 tgcataagca cacagccctg actggaccaa tgcttttgca aggttagaat catgtcttga 2335561 atattcattt caagcacctc cacttttctt tcataagttg actgcggcag caaccaaaaa 2335621 actcccgtct ctatgcttgc cagccgcaaa catagggacg agagttctcc cgcggttcca 2335681 ccctagttgc tgagaacaaa atcccagcct cttttttaaa attgctcaag aatgcctttc 2335741 gttgcgtgct catccttagc ttacaccgcc ctaaggtcgc tttcatgagg taaacgcaag 2335801 tacttctttc tctcactgca acatatttta taataaatga tcatataaaa agatggacca 2335861 aatgtcaact tttgttttca cccataagat gtttcatgct ttccatttga tctaaaaagc 2335921 gctttgattt taaatacaat cccgaatatt cttcgtaata taaatcaatc acttgcttta 2335981 attcagcttt tgtttcctct tttaaggaca cattgccgag tctcgacaga tcaaaatagt 2336041 aaaagagcct taacagcctt gccgtttgcg gtttaatcgg tatcctgtaa ggatcttttt 2336101 caaaacagcg gtggcatata aaaccattat cacgaacaga gaaatgaaag gttccgtctt 2336161 ggcttttaca atgtacacaa tgattcagct caggatacag gcccatgaca ccgagcatct 2336221 tcatttgaac aatgaaggtg ataacatccg gatctgttcc ttcattcaac tgttttaatg 2336281 attctaatat gaattcaaat aaataaggat ttggcttttt ttcttctgtg cctctgtcga 2336341 ctaactcagc aacataggca gcatatgctg ttaaaaacaa gtcttccctg atgcctctca 2336401 tgctgaggat catttccccc tgctgaagcg ttccgaggcc cgatgttttt tgcattaaga 2336461 aagaaccata caaaaagggc tggctgactg ctgataaacg gctgttcggt tttttggcgc 2336521 ctcgtgccat aacacctatt tttccgtgtt ctcttgtcag taatgttacg attttattcg 2336581 tctctccgta atcatttgtg cgaagaacga tcccttcaca ttttgtcagc atttccgcac 2336641 cttcctcaag caggagcggc caagaggttt ataaaattgg ataatcaaat cgggctagct 2336701 catcttctag ttcttcgggt ctttccatgt tctctttttc cagttcttta aaaagaagat 2336761 acgtatcaac atttcctgtt tgagaaaata cgttccaggt aaaattcaac acaagaaacc 2336821 cacctttctg tagttaaact agcttaccta aactccaaat tcttaccttt atcttgacca 2336881 gatgtcctcc atttcatgtt aaacaaaatt tgctaatgta tccctgttcc tgtgagataa 2336941 tgacacacac gggaagagat taatattcgt cctctttaaa gccaaaatcg cgaagctggg 2337001 acattttatt acgccagtct ttctgcactt tcacccacaa ttcaaggtag acacgggagc 2337061 ccaacagtgc ttcaatatcc gctctcgctc tttttccaac ctcttttaga aggcttcctt 2337121 ttttaccgat cacgatgcct ttctgggaat cccgctcgac cacaatcgtt gccgctacgt 2337181 gcacagaacc gttgtcctgc cctttgatgg attcgatggc caccgcaatg ctgtgcggga 2337241 tttcttctct cgtcaaatgc agcacctttt ccctgattaa ttcagaaatg ataaatcgtt 2337301 cagggtggtc agttacctgg tcactcggat agaattgcgg cccttccggc aaatacgctt 2337361 cgatctgcgc gagcaaggtt tcgatgttat ttccttctaa agcagaaatc ggaacaattt 2337421 ccttaaaagg ataacgtttg cggtattcgt caattagcag aagcaattgg tcgggatgaa 2337481 ttttatcaat tttgtttacg attaagaata caggcgtaga catcgtctgc aatttctcaa 2337541 tgatgaattc gtcgcccttc ccgtagcctt cctcagcatt gatcataaac aagatcaaat 2337601 cgacttcttt taatgtattt tgcgccactt tcatcataaa gtccccaagt ttatgcttag 2337661 gtttatgaat ccctggtgtg tcaataaaaa tggtttgtga tgtgcctgtc gtcagtactc 2337721 cttgcacctt gtttctcgtc gtttggggct tatcgctcat gatcgcgatt ttttgtccaa 2337781 tgactctgtt caaaaatgta gattttccta cgtttggtct tccaataatg gatacaaatc 2337841 ctgatttaaa gctttcgttc gtcatgtaaa tcctccgatg aaaatgcgcc tggcaataat 2337901 tcttccacag tcatttcttt tatttgtcct tgtaaattag tcagtacgac aataacgtct 2337961 tttgtgcaaa gctcagaaat cacctgtcgg caggctccgc acggagatac tggtccaggg 2338021 gtgtcagccg caacggccag catctgaaac tctgtatccc cttcagaaac agctttaaat 2338081 aaagcggtac gctcggcgca attgcacatg ctgtatgccg cgttctcaat attgcagcct 2338141 ctgtacactt ttccatcctt ggtaagaaga gcggctccta cttggaattt ggaatacggc 2338201 gcatatgcca tatcacgcgc ttttaaagct tctgttatta attcttgtct gttcatgtgt 2338261 acattcctct cttacctata atggtaccgc tatcacttta tattttacat aatcgcgcgc 2338321 tttttttcac gcccatttct aaaaatgtaa aataaatgta agaattttca gccattacag 2338381 ctttggcaaa aaaataagta aaccaatgat acacgaaatc acggcaaaaa cgcaaacagc 2338441 cccggcggca gcgtccttgg ccgctttagc aagagggtga tgtttgtcag ttattaaatc 2338501 aaccgtatgt tcaatggctg tatttaaaag ttcaagcgaa aacataccac ctatcaaaag 2338561 gaatataatc atccactcaa taatgctgag ctctacaagg aagccgcaaa tgagaacagc 2338621 gcaggcggct gcggcatgaa attggaaatt ccgctccgtc cgcgctgttt cccatatgcc 2338681 ccggcctgca tgcacgaagc ttttgaagaa tcgattcagc tcatttctat gatcttttga 2338741 gtccataagc gtccagcaat tccttttgct tagtaaacat ctcctcttct tcctctttcg 2338801 tcatatggtc atatcctaaa aggtgcagaa atccgtgtac agctagaaat ccgagctctc 2338861 ttttaaaaga atgattatac tcctctgcct gctctcttgt gcgatcggca ctgatgataa 2338921 tatcacctaa aaccggaggc atttcggcgc ccacgatttc gatctcgcct tctccctctt 2338981 cttcaagagc aaatgagatg acatctgtcg gagcatcctt tccccggtat tctttgttaa 2339041 tctgatgtat gtcatcattg gaaacaatcg tgacagaaac ttcagcctga tcctgaacgc 2339101 cttcacgctc agcggcaaat tgaagcagat tttctacttc tttgagcatc tcttctgaga 2339161 cgcttcccgt ttcatcaacg atatcaatca gtaaactcat ctatttcacc ttcttagtag 2339221 cctccggata ttcaatccgg gagtggaaaa ttccttttaa tgttgcacag agcgtttttg 2339281 cgattgtatc cagctcttta aatgtcaaat cgcattcact gaactgtccg tcctgaagct 2339341 tatcggatat aataccccgg acaagctttt caattcgttc aggatttgga ttgtgcatgg 2339401 atctgacggc cgcttcaaca ctgtcggcca ctgatataat tgcggcttcc tttgactgcg 2339461 gcttcggtcc cggataacgg aactcttcct ctgtaatctg gtcgcctttt tccttcgctt 2339521 tatagtaaaa aaactttaaa agcgaggttc catgatgctg ctcagcaata tcgacaagct 2339581 ctttcggaaa tttatagctt ctcagcatat tcgcaccgtc tgtcgtatgc gagataataa 2339641 tatttttgct caactgaggt gacagcttgt catgcggatt gtcaatattc atttggtttt 2339701 caataaaata ttgcgggcgc tttgtttttc cgagatcgtg ataatatgcg ccgactcttg 2339761 caagcaaacc attagcccca accgcttcac aggctgcctc tgataaattg gcaaccatta 2339821 cactgtgatg atatgtacct ggtgtttccg tcagtatttt gcgcaatagc ggatggttag 2339881 gattagacag ctcgagcagc ctcatggtgg ataaaatgcc aaagcccgtc tcaaaaaacg 2339941 gcatcagacc gatgatcaat acagatgaag caaaccccga cacaaccccc atgagcatta 2340001 acgtgccgat ttcaagaccc gacagcgcag tgttctggat caataataag gatagaacga 2340061 caaccatatt aataaacgcc acgaaaagtc cggtctgcaa aatctttgat cttgcattgt 2340121 gttttcctaa aaataataca cctgaaatgc cgctgatcaa ataataaatc cctatgacat 2340181 aattgaatgt tcctgtcaca ccctgattaa acatcatact tccgcaaatc gcaagaatga 2340241 tacttcccaa aatggcaatg cgttcattca tcagcagttt gattaagatg gcgccggccg 2340301 caatggggac cagatagccg atattattat actccatctt ctgaaacaaa ctgacaacct 2340361 ccatgatcac aagcaaaagt gttgtgatta tggagaataa cagaatggat tggtttttaa 2340421 acttcagatt ttgtttctgt ttttcaaaat aatatacaag tgttgcaatg aaaagtccga 2340481 tcataatcaa tagcccgctg atcggtttaa agagatttga gttatttaat aacccggtca 2340541 gctcaagttt cctgtacact tcccgatcaa tgaggtcatt ttcttccacg agcacttgcc 2340601 cctgtttgat ttgaacctgc tggacattat ctgaggcttc ctgccgtttt gcctctgttg 2340661 ctttcggatc gaagacgtaa ttcggaataa tagcaaaacg cccgatttct gtcgcggctc 2340721 ccaagtattt agacggaata gaattgctct ttagctcttt ttctacctta tcctttgcat 2340781 cagatagttt atccgaaggg atttcactgc tcatgaccgt atttaccgcg gtaatgaccg 2340841 tatctctgac aaaagaaaag tcttcactgt ctgctttcag caatgtcttg atggaatcct 2340901 ccgatataga atcattcaca tctgatgtca atttgtcctt tacagatttg accattgatt 2340961 tttccgatgg tgatttactg ccttcttccg atgatttttt cacttcacta atactgtcga 2341021 atattgatga cacaaggtca atccgattgt ctgtatattc tttttttaat gtatattgat 2341081 cttcaaccgc gtcctcagcg gcttgctttt tttcctctgt ggctttttga tcttctacgg 2341141 ttgccggagc gtaaatggtc ttgtcgctga ctgaaaacag gtctaaatca agtgtttccg 2341201 gcttaacatg tacaaagagc aaagcaaaca taatggcagc cagcagaaga tacagcagta 2341261 catgcatgga gcgggcattt ttaaaactgc tccatttttt tgagctgctt ttggtcttag 2341321 ccttcttttt caacacaaga acctcctctt gaaacatcaa gcccataagc aatcataaaa 2341381 atgacccgat aacgcgcgat cgggtcattc agcattaatt ttgcttatcg tatgcttcaa 2341441 taattttcgc aacaagcgga tgtctgacca cgtctgtctg gtctagctca atcatagaaa 2341501 tgccgtctat tcctttcagc atctccttcg ctactgcaag tcccgatttg acgcctttcg 2341561 gcagatcaat ttggctaacg tcacctgtaa tgatcatttt agagccaaaa cccagtctcg 2341621 tcaaaaacat tttcatttga gcaggcgtgg tattctgtgc ttcatcaagt ataacataag 2341681 catcatcgag cgtccgtccc ctcatatatg cgagcggagc aatttcaatg atgcctcttt 2341741 ccatcagacg ttctgtatga tctgccccaa gcacatcatg gagagcgtca tacagcgggc 2341801 gcaaataagg atctactttt tcttttaggt cacctgggag aaaaccaagg ctttcaccgg 2341861 cttccacggc aggtcttgtt aaaatgattt ttttgatatg tccgtttttt aaagcatgga 2341921 ctgcttttac gacagccagg tacgttttcc cggttcccgc cggaccaatg ccgaatacaa 2341981 ggtcattccg cttcatagcg gccacgtatt cccgctgtcc cattgttttt acacggattg 2342041 atttgccttt tgcgtttttt gtaatttctt cttcatacat gctttcaaag tattcaagtt 2342101 cattcttctt tgccattttg atggcgtaaa tcacatcacg ttcagagatc tctatcccct 2342161 tgcgaattaa agcgaggagc gatcccagca gcctgtctgc aatctgaaac gattcatcat 2342221 cgcctgaaac ataaatcgtc tcgccgcgcg taatgatatt taaattcaga tctttctcca 2342281 tcaatttcaa aaaagaatct tggttcccga agagtgaaag cgcctcgtcc gggtttttca 2342341 gtttttgatt catcgcaagt aaatgttctg tcattcttca gtctccctga caataggtgt 2342401 ggtttgaacg atatcttcta taacttggta gagaataatc aactttactt taccattctc 2342461 aacagtctgg tgcaaaactt tttcactttt cacctcgccg ttttcgccta ttttatcctc 2342521 tacatcctgt ttacccaatt taatgccttc ttgaactgct tcttcttttg tatattttcg 2342581 caaagcctct tcactttctc tcgtttgctc tttgacatag gatacaggga gcttaaatcc 2342641 gagaaaatga agcgaatgct tttcttgttc tgtttttgga tgcttcaatt cctctttttt 2342701 aaacgtcatc ccccagatcg ggattgccaa agaaccaaaa gaaagcttgt gctttgtcct 2342761 tactttgccc gtatagacgt taaataatgt ttcaagcggg actgtcactt ctgatctata 2342821 ccaggtttct ccataaattt ctgcttttga ggcgacttcc tgctgatggt cttcgctgcc 2342881 gatcagtccc gaaacaagca gctgtccctt ttcaacatga tcgtgtatgg cggccatggg 2342941 ctgtcctttt tgcacaaaca ttctcgtaat ggttgctttc tttttggcga caatattgcg 2343001 cgggctaaca tatttttctt tttcgggctc atttttctcc acaactttca tatgaatggt 2343061 cgtccccttc agatcaactc cgacccaagt gatattgtct attccattgg ttaatgattt 2343121 ctgtattttt tcgggcgaca tcattaaaaa ctgcagacgg ccctttttga cgccgatttc 2343181 attaagatgc tgcctcattt gatgttctgt ttcaggctta gcgcctgtca catcaatttt 2343241 ccacaccata ttggacagca aaaacaaaag aatgaaaaaa atcgcaaaac cgatcgtaaa 2343301 ccctatattc agctttgatt tcagcaacag gaagggaaat cccttccgat tgataaatcg 2343361 ggctttacat ttaaatttac ttcttacccg ccgaaaggca tgtacatcct gaagctgtat 2343421 atataacgat acggcttctt tctttttttt gacatgaaag accggaatcc cctgtcttgt 2343481 gcattcatta aggagccgct caatccctct tcccgtcaat tcaagctgga ccttacccga 2343541 aaaaaaagac agccatttat ttttcacaac atttccccct cggctttatg actcaacata 2343601 tcgaacgaca tcaatcgtac cctccaaaag tatctcttcc ggaagaatcg ccttgatgac 2343661 aaaattttta ccagatatga tgcactggcc ctgcttcagc atcagccgca cttcattctc 2343721 actgaaaagc aaaaggcctc tgtggttttc tatgtagata tgaagtctgc caaccattgt 2343781 aatcctcggc agatccatca taacgtccgg gggaatttcc aatgctcttg tcagccaagc 2343841 tttcatacga ttctttcttt gccccataca aaaagaaccc cctttcatct catatgtatg 2343901 atttgaaagg aggttctaac actttaattt ttacgggccg ggcgcatcgt acggtgaggt 2343961 tttttcgccc gtggaggtcc gaacacctct cctagaacga tcccctgtac gacggtgtct 2344021 ttattcacct gaagcatttt ttgttttgtg tatactgttt tttgtttggc agcagcaaga 2344081 tctcgttcca gccctttcag gtttcttgct gtttccctgc gtctttcttc cgcttcccgt 2344141 cttgcctgtt ccatacggtt agggataggt gcaggggcat cttcttttga ctgcttcttt 2344201 tgaggagaag cagattgcac gtgttgaggt ttttttcttt tttggctgtt ttgcttttct 2344261 tctttgctct ttttgccgaa aatcgcagaa atgattccga tgatcgctgc aataataagc 2344321 ggattggtca gtaaatcttc catcagcgtt ctcccttctt agagagatta tgatttgcgg 2344381 tcttcatccg aagggtcttt cgtcagcttg ccgaatgaat cacgcatttc tgtgtcagca 2344441 tcgatgttct tgatattcat gtaatccatg acgccaatat tcccttcacg caaagcttct 2344501 gccatcgcaa gcggcacttc cgcctcggct tctactactt tcgcgcgcat ttcttctacg 2344561 cgggcacgca tttcctgttc ttgagcgaca gccatcgcac gtcgttcttc cgcttttgcc 2344621 tgcgcgatgt ttttatcagc ctcggcctga tcggtttgta aaattgcccc gatgtttttg 2344681 ccgatatcta catctgcaat atcaattgag agaatttcaa acgcagttcc tgagtccaat 2344741 ccttttccaa ggactgtctg agaaatcatg tcagggtttt caagcacttt tttatgatta 2344801 tcagatgaac cgattgtaga aacgattccc tcacctacac gagctacaat ggtttcttcc 2344861 cctgctcccc cgacgaggcg ctcgatattc gctcttactg tgattctcgc tttcgctttc 2344921 acttcaatcc cgtccattgc gacgccggca atgaacggtg tttcaatcac cttaggatta 2344981 acgctcattt gaacagcttc caacacgtcc cggcctgcaa gatcaatggc agcacagcgc 2345041 tcgaatgtga gttcaatgtt agctcgctga gcggcgataa gcgcgttgac gactctgtca 2345101 acattacctc cagccagata gtggctttca agctggtttg ttccaacatt aagtcccgct 2345161 ttatgcgctt taatcagcgg gttaacaacc cgattcggaa tgacgcggcg aagcctcatc 2345221 ccaactagag tgaaaatgct gattttcact ccggctgcca aagctgaaat ccaaagcatt 2345281 acaggcacaa atgtaaaaaa tactgccaaa acaatgatcg ctactgcgac aattgccaga 2345341 atcataagtg ttgacggatc catataactt ctcctcgttt ctatttaaat ttctctcacg 2345401 acaatgcgtg agccttctac ttttatcact tttacttttt tatctttttc tgtaaacgat 2345461 ccctccgata caacgtcaag gcgttcatca tcaataatca cggtaccgga aggacgcagc 2345521 ggtgtaaagg ttatacccac ttttcccatt aagtccgtgc gcgtttgatt tgaaacgtag 2345581 ccgctctccg tgtttgtaga atcatttaat atcaatttct taaagaattt catacgcttt 2345641 cccaacaccc ttgtcagtaa aataaaagct gtaatcgaaa cagctgaggc gatcaagaga 2345701 gaaaccgcca tgacagtgaa gctccccgcg gctaaaaaca ggctcgcaat aatcgctccc 2345761 aagcccagta atccaatgat tcctccggga agaaaaatct caagcagaat gagaatcacc 2345821 cctgctataa agaggagaac cgtctcatac ccggcaaggc cggctgcaag atgcccgtaa 2345881 aagaacagca ataacgcaat gagtccagcc gttccaggga ggccgacacc cggggaaaaa 2345941 agctctaccg tcagacctaa aaaagcgatt gtcagcagaa tagggacaat gaccggattc 2346001 gtcagccatc ttgccgtctt ttccgcaaag ctctcctttg catagctgat ctgcgccttt 2346061 tcgaacccaa gcttctttac gagcgtggac aaattgtcag cagtgccttc tgaatagcct 2346121 acctcaatcg ccttgtctgc gttaagtgtc agcagatctc ccttaggcgc gccaacttcc 2346181 ttggcatcta tatctgggtc agccattgcg agcgcatatt ttggatcgcg gttatttttc 2346241 actgcggcat cttccatctc tgccagccaa agtgattgag ctttttggtc agcggcattg 2346301 ccttggccat caacaatcgc ggcggctccc atttttccgc caggcgccat ataaatgtga 2346361 tctgcttgaa gtgcaatata tgcaccagca gacaacgcgc gtttgttgac atatgcagtt 2346421 acggggatct cgctttcggt tatcaaatcg gccatatcaa tagcagattt gaccaatccc 2346481 cccggggtat tgatatcaag aataatatgg tctgcatgtg catcctttgc gtcttgtaac 2346541 gaacgggaca aaaacgaggc gagaccctgt tcgacatttt tttcaaccgg gatcacataa 2346601 acagtttgtt tttctgcttt tgcgttcagc tgtacgccta ataaagaaag taaaaatata 2346661 cccaaaagag cagcacggaa tcctttgatt tgaagcaagg gcggtgtatc cctccttcct 2346721 tttataataa gtgccttctc ttcatacgta acaaatgtat caaaggtttc atttttttat 2346781 gtataaaaaa agacatctct cttagaaaga tgtccttttc tttgccattt aagacagttg 2346841 actgctcaca agcttattaa ttaaacttcc gtcagcttta ccttttactt taggcataat 2346901 tgcccccatc actttgccca tgtccgcttt tgagctcgca ccgacctccg cgatggtttc 2346961 atttacgatt gtacgcagct cttcttctga cagctgctca ggtaaataaa cttctaaaat 2347021 gtccagctct ttttgaactt tatctactaa atctaaacga ttagcgtttg aaaattcctg 2347081 gagggagtct ttacgttgct taagttcacg agaaaggaca gtgagttcct catcctcggt 2347141 caaactgtct ttcttaagct taattgcttc attttgaagt gaagccttaa ccattcgaac 2347201 gacagtcagt ttgtctttct cacggttttt catatacagc ttcatatcct ggttgagacg 2347261 ctcaagaaga ctcataaatc caccctcttt tagaatttgc gttttctagc agcttcagac 2347321 tttttcttgc gctttacgct aggtttttca taaaattcac gctttcttgc ttcttgcaaa 2347381 gtacctgtct ttgatacact gcgtttgaag cgacgaagag catcttcaag cgattcgttt 2347441 tttctaacga ccgtttttga cattctcttt ccctccctcc gaatacacca atcgactacc 2347501 tttaagttac acatataaac atgtactttg acattataat ataagccatc agtcaggtca 2347561 actaagtgag ttcacttttc cgtcatgagt gcgactgcct gtctatataa tgaaagaaag 2347621 gggttggtga ataggatgtt aattctgatt agctttactg ctcttatatt attctttctc 2347681 gcaggcatga acatgcttcg aaagggctta atttcaatgg cgtactcaaa aattgaagaa 2347741 cgtttgcttt tatttacaga ccatccgtta aaagcgtttc ttatcagtat tgtatttacg 2347801 gggatacttc agagcagctc agcctttatg gtcattgtca tcggctttgt aagtgcgggc 2347861 gttctttctt ttaagcggac gatcccgatg attctgggga caaatgttgg ctctactttt 2347921 acaactgaat ttattgctat caaaatggat attgtgattt gggttctttt aataggaggt 2347981 ttattgtttt ttctgactgg caggtatcct ttgaaacagc tgggaacaag cttccttgga 2348041 ctgggcatca tcttcttttg catcagcgga ttcagccatc ttgccgggcc gctgacaaag 2348101 ctgaaaacgg gcgccgacgt tctataccat gttaacgatt caaactggtc cgctttgctc 2348161 atcggcatgg tgttaactgc catcattcac tccagttctg tctgtatcgg cattttgatg 2348221 agttttatga atgaagggat tatcggactg acacaggcga tgagcgtcgt actcggatca 2348281 aatatcggga catgcattac agctgtcatg gctgctgtat ccggcggata tgcggcgaaa 2348341 cagacagcat atgcccatgt ggtatttaac gtgctagggg tggctctagt attgcctttt 2348401 ctgaccgcag cgaccggctt tgtagagcag ttatcacctg atcccgcaca aaagatcgcg 2348461 catttcagcc ttttatttaa tgtggtgaca gctcttttat ttcttccgct tacaaacttg 2348521 ttttaccgat tgattcacct tcttatcccg gctaaataaa aaaatcggta cattttaatg 2348581 caccgatttt ttaggttaag aagacaaacg catgtgttca gttatttcat cctcaaccac 2348641 acggacaaac tgtccttcgt tgtaaggata acctgctttt aggattttga cttttacgat 2348701 tttgccgatc atatcttccg tacctttgaa aacaaccttc atataattgt ctgtgtaacc 2348761 gacaaacata ttttcttctt ctgtttcctt aaacgcttcc tcagggataa tctcaagcac 2348821 ttcattttca tactgagaag cgtattcttt tgcaagctgg tcagaaagag caatcaggcg 2348881 gtgcacacgt tcgtttttca cgttttcatc cacttggtct tccattcgtg cagctggtgt 2348941 tcctgtacgc ttactgtaag ggaaaacatg cagctcagag aatttatgtt ctttaataaa 2349001 gttataggtt tccataaatt cttcttctgt ttctccaggg aacccgacga tgacatcaga 2349061 agtaacagct aagcctggca gtgctttttt caatttattt aaacggtctg caaagaattc 2349121 cattgtatat ttgcgtctca tccgtttaag cactgtgttt gatccggatt ggataggaat 2349181 atgcaaatga ttcactatct tatctgagcg gtctaagacc tcgatcactt cgtcagtgat 2349241 ttggctggct tcgattgaag aaattctgat ccgtttcacg ccttccacac gggtgtctaa 2349301 ttcgctcaaa agcttcgcga agttgtaatc tttcatatct tcgccgtagc cgcctgtatg 2349361 aatacccgta agaacaattt ccttatatcc ggcatcgaca agctgctgcg cttgtttaat 2349421 gacttcttca gggtcgcggg agcggagcag gcctctcgcc cacggaatga tacagaatgt 2349481 gcagaaatta ttgcagccct cctgtatttt caatgacgct cttgtgcggt ccgtgaaagc 2349541 aggcacatca agctcttcat atactcttgc tttcatgatg ttgctgacgc cattaatcgg 2349601 ctggcgttct tctcggtatt ggtcaatgta gccaagcatt ttttcacggt cctgtgttcc 2349661 gactacaatg tcgacaccgg ggatcgccat aatctcagca ggtgaggttt gcgcgtagca 2349721 gcctgtgaca cagatgacac cgtcaggatt ttgacgaatg gcgcgtctga tcacttggcg 2349781 gcttttttta tctcccgtat ttgtaaccgt acatgtatta atgacatata catcagctgt 2349841 ttgttcaaag tctcttcttt catagcccgc ttctttgaaa agctgccaga ttgcttctgt 2349901 ttcataatgg ttgactttac agccaagcgt atggaaagca acagttgcca ttactgatca 2349961 cctcttaata actctgtttg ataagaaatc gcactcaacg cgtatagcgg agcggtttct 2350021 gtccttaaaa ttctcggtcc aaggccgcac gtcacaccgt cttgctctgt gagccgttca 2350081 acctccgctt ctgttaaacc gccttcggga ccaaatacga tcaatagaga tgatcctttc 2350141 ggaaggctgc ttacaatcgc gctgaatgcg cttatttccc cttgcttcga tgactcctcg 2350201 tatgcaacga cacatttatc gaaatcctgc atcctttgaa gaagctgctg aaaagaatgg 2350261 acatccatca ctcgcggcac ttcgttacgg tacgattgct cagccgcttc cttcgcaatt 2350321 ttcgtccatc tttcccgctt tttctttgcc tttttgtcat ccagcttgac aacagaacgc 2350381 gcggcttgga aaggaataaa ggcatgagct ccgagctcag tccccttttg gataatccat 2350441 tcaagcttat ctcctttcgg aaggccgctc gcaatataga cctttatcgg aagctctctg 2350501 ttttcattcg tccattctat cacaaggcag gacactttat ctttggaaac agattgaagt 2350561 tcacattttg cctcgaagcc gtcttgagag cagcagataa tctgatctcc ctcattcatt 2350621 ctcatcacgt tcacaatatg atgaacttct tcgccggtaa tcgaaaaagt cggcgcttcc 2350681 tctatttgct gcttcgtgag ctcgataaaa tatcgttgca tacgctgtga cacctactaa 2350741 ctgttatttt ttcgcaataa tgctgaccca atcttccatt gaaaggattt ctacaatggt 2350801 aaagccagct tgttccagtg cttcttttac ttcttgtttt ttatgaccga tgattcctga 2350861 cgtaataaag tgaccgcctt cttttaacag gctgtacgct tgtgaagtaa agcgaagaat 2350921 gacttcagcc aaaatgttgg ccacaatcac atcatgttcc ccttcaatcc cgtctaacaa 2350981 attgttttgc ttcacttgag caatatcgct gactttgttc agcttgagat tgaggcgtgc 2351041 actttctaca gccacgggat caagatcgta ggcatgaacc gattcagcct caagcattgc 2351101 agccgcaata cttaaaattc ccgaaccagt gccgacatca atcaccttat cacccttttg 2351161 cacaaagcgt tcaagcgcct gaatgcagag tacggttgtc ggatgtgtcc ctgtgccgaa 2351221 agccattccc gggtccattt caataatcag ttcatcagta tggaccggcg tatattcctc 2351281 ccacgtcggc acaattgtaa acttttcaga aattttcaca ggatgataat actttttcca 2351341 ggcagtcgcc cactcttctt catttacttc agaaatagtg atgtggtttc tgcccaaatc 2351401 aatattgtaa agaaggagat tattaatcgt ttctttgatg ccgtctacag tttcgcccag 2351461 aaaactgtta accggcagat atgctttgac aatgacaccc tcatctgggt aatcattggg 2351521 gtcgagctgg tagatttccc cgtacacatt ctcacgttct ttaattaaat caagcgggtc 2351581 ctctatcaca accccacttg caccagcttc atgcaatata tttgagatag gttcgaccgc 2351641 ttcatgtgtt gtgtgaatgc ttaattcgga ccatttcaaa actaccaact cctcatccaa 2351701 taattaatcg cctttaaacg cgcgttttac cttgtcaaag aaactcattt cctgttcgtc 2351761 aggcaggttt ccgctgactt cggcaaattc gcggataatg tctttttgtt tatcagtcag 2351821 atttgtcggc gtaacgacgc ggacgacgat atgctggtca ccctgtccat agcctctgac 2351881 attttgaacg cctttgcctc ttaatctgaa tttcgttcct gtttgtgtac cggccggaat 2351941 tttcaatttc acttttccat gcagcgtcgg cacttctacc tcatctccaa gagcagcctg 2352001 agcaaacgtt aacggcattt cacagtaaat atcatcgccg tcacgctcga agaactcgtg 2352061 tgcgcgtaca tggaacacga caaataaatc cccggcaggg ccgccgttta ttcctggttc 2352121 accctgtccc gagagacgaa gctgctgccc gtcatctaca ccggctggaa ttgtcacatt 2352181 gattttcttg cgttttttga tttttccttt gccgccgcag tccgcacatt tgtttttaat 2352241 gattttgcct gtaccttcac agtggtggca gacccgtctg ttaacgactt ttccaaacgg 2352301 tgtattttgc tccacgttta actggccgga gcctccgcag tgggagcatg tttctggatt 2352361 tgttccaggt ttcgcacctg agcctttaca tgtttcgcac gtttcctcgc ggggaatttc 2352421 gatggttgtt tctttaccga aagccgcatc ctcaaacgac agggtcatcg tatactgtaa 2352481 atcagcaccc tggcgcggag cgtttggatc tcttcgtctt gtgcctccgc cgaatatact 2352541 tgagaaaata tcatcgaaac caaaaccgcc gaaatcgccg ccgccaaaac ctccgccgcc 2352601 gaagccttgg ttagggtcag tgtgaccaaa ttgatcgtaa tgcgcacgtt tttggtcatc 2352661 tgacagcgtt tcgtatgctt cttttacctc tttaaatttt tcatctgatc cggcttcttt 2352721 gttaatatca ggatgatatt tttttgacag cttccgataa gcttttttaa tttcatcctt 2352781 tgaagcgctc ttacttactc ccagcacttc atagtaatca cgcttactca tctcgcttca 2352841 ctctcccgaa tttctcacat aaattagatt gtatcatttt gaattatgat ttttcaattc 2352901 cttttatccc gggcaagaaa aaaagtcaaa gccaagagat gcctgacttt gactttctaa 2352961 tcattgaatc agattatgaa atgtgttctt ttcggtcagc tccggaagcg gggctgacac 2353021 taaaaagaac ttattttttg ttttggtcgt cgtttacttc ttcgtattca gcgtcgacaa 2353081 cgttgtcatc cgctttgcct tcagcgtttg ctccgccttg agcttgctgt gctttagcag 2353141 cttcttcata aagcttcata gaaagctctt gaacgattgt ttgaagctca tcttttttcg 2353201 ctttgatctc ttcaaattcg tttttctcaa tcgctgcttt taaagcgtct ttggcatcgt 2353261 tggctttttt cacttgttct tcgtccactt tgccttcaag atcttttaat gttttctcag 2353321 tttggaaaac aagctgatct gcttcgttgc ggacttcgat ttcttctttt ttcttcgcat 2353381 cagcgtcagc attttcttcc gcttctttta ccatgcgttc gatctcttca tctgagagac 2353441 ctgaagaaga tttgattgta atgttttgtt cttttcctgt gcctaagtct tttgctctta 2353501 cgtttacgat accgtttttg tcaatatcga aagaaacttc gatttgaggc acgccgcgcg 2353561 gtgctggcgg gatatcagta agctggaagc ggccgagtgt tttgttgtcg gcagacattg 2353621 ggcgctcacc ttgaagaaca tggatatcaa cagctgtttg gttatcagca gcagttgaga 2353681 acacttgaga tttgcttgtt gggatcgtcg tgttgcggtc gatcagtttt gtaaacacac 2353741 cgcccattgt ttcgataccg agagaaagcg gtgtaacgtc aagaagaaca acatctttta 2353801 cgtcacctgt gataacgccg ccctgaatcg cagcaccaag cgctacaact tcatccgggt 2353861 ttacgccttt atgcgcttct tttccagttt cttttttgat tgcttcttgt acggcaggga 2353921 tacgagttga tccgccgaca aggatgactt tgtcgatttc gcttgcagaa agtcctgcat 2353981 cttgaagcgc ttgacggaca ggacccattg tgcgctctac taaatgagaa gaaagctctt 2354041 cgaatttagc gcgagttaat gtaagttcaa ggtgaagcgg tcctgcttct ccagctgtga 2354101 taaacggtaa agaaatttgc gtagaagata cgccggaaag atcttttttc gctttttcag 2354161 ctgcgtcttt caaacgctga agcgccattt tgtcttttga caaatcaatg ccgttttctt 2354221 ttttgaattc agacaccaga tgatcgatga taacttggtc aaaatcgtcc ccacccagac 2354281 ggttgtcgcc ggcagttgaa cgaacttcga atacaccgtc gccaagctca aggatggaaa 2354341 cgtcgaatgt accgccgcca aggtcgtata ctaggatcgt ttgatcttca tctgttttat 2354401 caagtccgta tgcaagcgct gctgcagtcg gctcgttgat gatacgttct acttcaagac 2354461 ctgcaatttt accagcgtct tttgttgctt gacgctcagc atcgttaaag tatgcaggaa 2354521 ctgtgataac tgcttttgat actgtttcgc caagatagct ttcagcgtat gatttaaggt 2354581 gttgaaggat gatagcagac acttcttgtg gagtgtaatc ctttccttca atttcaactt 2354641 tataatcagt acccatatga cgtttgatag acataattgt gttagggttt gtaatagatt 2354701 ggcgtttagc cacttcccct acttgacgtt cgccgttttt aaatgcaaca actgatggcg 2354761 ttgtgcggtt tccttcagcg ttagcaataa ctttaggctc gccgccttca agcactgcca 2354821 cacatgagtt tgttgttcct aagtcgattc cgataacttt actcacttga ataacctcct 2354881 gctatgtaat tattgattca ctttgaccat ggaagggcga atgacgcgat ccttcagctt 2354941 atagcctttt tgcatttcct caacaacaat gttggagccg tagttttcgt cttcagcctg 2355001 cataacagct tggtgcagat taggatcaaa ttcctgccct acagcttcga tggcttcgac 2355061 gccttctttt ttcaaggctt ctacgagctg acggtggacc atttccattc cctggagcaa 2355121 acttttcgtc tgttcattgt cggcttcaac ctgaagcgct cgttcaaaac tgtcaagagc 2355181 cggcagcaaa tcagtcacga tattttgaga acggtatttt tgggacgctt ccatctctaa 2355241 acggctgcgt cgtttatagt tttcaaagtc tgcttgaaca cgcaaaagtt tgttttcttt 2355301 ttcctcaagc aaaccttgca attcgttaat ttggttttga agaagttcgc tttcatttgt 2355361 ttcttcctgc tgttcatcag cggcagcttg ttcttcaatg atttcttgct cttctgtttc 2355421 gttttgttca acggtttgtt tttcttctga cattgtgttc acctccctca aagtgtaagg 2355481 agaaggacag gtgctgccct tcgataaaat ttgccaaaat tcccttattc atcatacaga 2355541 cttgttaatg cttttgacaa gtccgaagtc acatgctgaa gcaggctgac aaccctggaa 2355601 taattcatgc gggtcgggcc gataatcgca attgagccga tctgcttctg gtctacggaa 2355661 taagaagccg taatcagact gcaattttcc atctcttcat agtcgttttc ttttccgatt 2355721 ttaatcgaaa ttcccgtgtg cggggattga accagcttta aaacatcctg ttctttctca 2355781 attaatgaaa gcagcgaccg aactcgggtg atatcatgga actcaggctg gttcagcata 2355841 ttgattttcc cgccaaaaaa caacttttca acgtgatttg tggaatgaaa ggttgaacga 2355901 agcgcgtcga gtatattgtc atagttttta atgtgctgtc ttaggtacat gacaacttct 2355961 ttaaatatgc gctcattcag ttcatccatt ggaacgccgc ttaaacggtc gttcagtata 2356021 tttaccagtt tttcaatatc agacagatcc attttggtcg gaaagttaat cgttttgttt 2356081 tccacatgcc ccgtattggt aacgagaatc gctaccgcca tatcaggctg aatcggaatg 2356141 atttgaatct gtttaaggta attctcactc aacttcggcc cgagtacgat ggatgtgtaa 2356201 ttcgtcagat cggacaaaat ttgcgctgat ttttgaactg tcttctccag ctcgaaaatt 2356261 ttctctttga agatcgagtg gatttggtcc aggtcgcttt tcgtcaattt gacgggtgac 2356321 agcaaatggt caacatagta ccgataccct ttttctgacg gaacacgtcc tgaggatgaa 2356381 tgggtttttt caataaagcc caattcctcc aagtcagcca tctcgtttct tattgttgca 2356441 gagctaaatg tgatttcatc ttttttcgaa agagttcttg atcccaccgg ctgtgccgat 2356501 ttaataaaat cgttgattat aacctgaagg atcagcagct gacgatttgt taacatcatc 2356561 atcacctctg ttagcactct caataagcga gtgctaattc tataacaaaa gtatcaaacc 2356621 acaagaaaaa tgtcaattat aactcaccca aaaaagcgcc aaaaacttca ttgcctaata 2356681 atttcccttg atgagtcaaa taaacggcag actccgaatt gtgaatcagc cctttttcag 2356741 cgaggtcttt taacacgctt gggaaaagtc catccaggga acggccgtat ttttctgcga 2356801 atcgtttttt gctgacaccg gctgtttttc tcaaacctaa aaacatttct tcctcaatct 2356861 gttcttctgt tgtcacttca tgtgtatctc tgtacggaaa acccttttca gctatcaggt 2356921 caatgtaatg cttaacaggt ccgacgttca ctgttcgtgt gccgccaata tatccgtgag 2356981 cgccagctcc gaaaccgaaa tattgttcgt tgctccaata cgttagattg tgcttagatt 2357041 ccatgcctgc cttagcaaag ttgctgattt catattgatg aatgccgtga gcttccatct 2357101 tgctcatcac tatttcatac atttcagctt cctgctcctg cggcggaaga tgaagccgcc 2357161 ctttttgcat caaattataa aataccgttt tcggttctac aataagggag taaacggaat 2357221 aatgctcagc gtccaatgat aaagcagtgt ttatggaatg ttccagatgc ttgagggttt 2357281 gccccggaag cccgaacatg agatcaagac tgatattctc aaaaccgatt tcccgcgctc 2357341 tttcaaaaga ggtgaataca tctttttgct tgtgcactcg gccgattttt tctaacagat 2357401 cgtcttcgaa cgtttgcaca ccaaagctaa ggcgatttac gcctgcttct tttaatattt 2357461 ttaatttctc tgcggacaaa tcgtccggat tcgcttcaac cgcaaattcc gataagtcgc 2357521 ttgagggctt tagcacgcgg ttgatcatat ccatcagctt tttaagctgt tcctcagaca 2357581 gggaggtcgg cgtgcctcct ccgataaaga ttgttttgag atcaggctgc ccggtttttg 2357641 ctattgtatt tatcatttcc tgttcgagtg cgtttaaata ctcgtcgact ggctgacttt 2357701 gaataaaata tttattgaaa tcgcagtagt ggcaaatatg ctcacaaaat gggatatgga 2357761 tataagctga tttcaacgga ttcaccttct ttacagaaag aagccgcagt acaagactgc 2357821 ggcggcttct attgtttttt cggactgtcg tccattttca gaactgccat aaatgcttct 2357881 tgcggcactt caactgagcc gacctgcttc atacggcgct ttccttcttt ttgtttttca 2357941 agaagtttcc gtttacgcga gatgtcccct ccgtaacatt tagccaatac gtttttacgc 2358001 attgctttta tggtggagcg ggccacgatt ttctggccga ttgcggcttg taccggaact 2358061 tcaaactgct ggcgcggaat gagttctttc agtttttcaa cgatcacttt tccccgttca 2358121 tatgcgtaat cacgatgcac gataaaggaa agggcatcga ttttttcacc attcagcata 2358181 atgtccattt tcacaagctt ggacggtttg tagccgatca gttcataatc aaaggacgca 2358241 tagcctttag tgcttgattt cagctgatca aaaaactcat atacgatttc cgctaatggc 2358301 atatcataaa tgatgctgac acggtttgcg tctaaatact gcatatcaat gaaattgccg 2358361 cgttttcctt ggcaaagctc cattacagcg ccgacatagt cattcggcac catcatcgtc 2358421 gcttttacgt atggctcctc aaccctttcg atcttttgag gatccggcat gttggacggg 2358481 ttgtcgacaa cgaccttttc gccgtctgtc atatacacgt catagataac gcttggcgct 2358541 gtcgtaatca ggtcgatgtt gaactcacgc tcaattcgct cctgaatgat ctccatgtga 2358601 agcatgccta aaaatccgca gcggaacccg aatccaagcg cttgcgaagt ttccgcttca 2358661 tattgaaggg aggaatcatt cagctcaagc ttttcaagag cttcccttaa atcattatac 2358721 ttcgctgtat caatcggata caaaccacag tacaccatcg ggtttagctt gcggtatccc 2358781 ggcagcgctt cttctgcagg attggcagcg ctcgttattg tatcaccgac acgtgtgtca 2358841 ccaacatttt tgattgaggc agtcaggaag cctacatcac cgaccgtcag ttcatttgtc 2358901 ggagttgctt tcggcgtgaa cacgcccacc tctgttactt cgaattcttt gccggttgcc 2358961 atcattttga ttttttgtcc cggctttacc gttccttcaa cgactctgat ataagccacg 2359021 acaccgcggt aggcgtcata aagcgagtcg aagatcagcg ctttgagcgg cgcctccgga 2359081 tctccggtcg gagctggcac cttttctacg atttgttcta aaatctcctc aatcccgata 2359141 ccggcttttg ctgaagcaag cacggcttct gatgcgtcaa ggccgataac gtcttctacc 2359201 tcttggcgca cacgttcggg ctcggcgctc ggaaggtcga ttttattgat gaccggaagg 2359261 atttcaagat cgttgtcaag cgctaagtag acattggcga gcgtctgcgc ttcaatcccc 2359321 tgggctgcat ccacgacaag aatcgctccc tcgcaggcag caaggcttcg ggatacttca 2359381 tacgtgaagt cgacgtgtcc cggcgtatcg attagatgaa agatatattc ttctccgtct 2359441 tttgctttat atttaagctg aacagagttt aatttaatgg ttatgccccg ctcacgttca 2359501 agatccatag aatcgagcaa ttgttctttc atttctcgtt gagtgattgc cgacgttttt 2359561 tctaaaatac gatccgctaa ggtcgatttt ccgtggtcaa tatgggcaat gatagagaaa 2359621 ttccgtattc tcgattgcct ctctaaacgc ttttctttat ctgtcacaat ctatcactcc 2359681 tactattaaa cgcaaaatac actagcttag attatatcaa taggattgta aagattcaat 2359741 gtaaaacaag aaagagaaaa gttccctatc atatctgggt tgcttttctc tttcacgtac 2359801 ttattgattc atatcccgta tccattcata cattgactgg gcagtattgg ttacggtgtc 2359861 cgaaagcgct tttccggctt ttgaaaacat attgaatgtc tccacctttt ccagctcttt 2359921 ttgtttttct actaaatctt ttgccgtgac tgtttctcct aggattgagg cttctttttc 2359981 attatctttt ccgtcggtga gcgtaaacgc ccccttcagt gaagggtcat gatagccttt 2360041 catactcagc atcccgtggt ttgcctgctg catgccgaac agaacgccta aaaacatgat 2360101 cgtgacaagc agtaagcact ttccaaagta tgcaatcaaa tcaaccacct atttcttatt 2360161 gttttttcgt ctccccgctc gctgcgttga ccttttcagc atcccagtac atttcgctga 2360221 atacgtccgc ggccgcgtta gccgcacgct gcagctcttc gagattatta tccactccgc 2360281 caaactcgag caaaagcgct ctatcggtta aatcctgatt gtaaacacca ttatcgcctg 2360341 gcgagccttt ggaaaagaca cctgtgctaa gtccggggta ttttttctcc atcagtttat 2360401 gaagctcact cgcaatttta tagttttctt cgaagttttt gctttttttc ccgacgacaa 2360461 aggctaccct ggcatagctt ttccctttaa tcgttgcggt tgtgtctttt ttgcgccgag 2360521 agtctctgtg gatgtcaatg atatattgca gatttttgtt tgaagcgagg gcgtctttca 2360581 cgaccggcct tgattcatca taggacctgg catagtttaa gcctttttta ttcaattttg 2360641 actgtatatc ggttttattc actgtggctc cgattccctg ggattcaagc gcttgtccga 2360701 acatatctcc tacaagcgtg acattggctt tagaatggcg cgccatgtca ggatcggtct 2360761 cgccttttaa tagagggaga tatgattccg tattgtgcgt gtgatagata aacacgacct 2360821 ttttatcacc tgttgtttgt ttcggcggat ctttttgcgc attatctgat tgcgtttgct 2360881 gtttttcaat ctctgccaaa ttcgcttctc tttcttcctc catcacctta gacggcggcg 2360941 gcgattccgc aggcatattc gtataatccg ttccttgtcc agctaacaaa atctcggtat 2361001 caaattgtgc aaatcctggc agctcccgac cgagaaagct ccgcggatct tcgaggttaa 2361061 tgctcgtcgc cagctttaaa gaaagacgag aaagatgaaa tgagctgtct gtttgagaga 2361121 ggtcagaagc gaaataatgg ttttccatct gcagcaaatg tgcaaatacg tcacccggca 2361181 attcttcagc aatcccataa aaagagtcag acgacggcct aagttccggc cggagagacg 2361241 tcagcacacc ggatagaaca aaaatcacga taaggcttac gataaataga aagatggctt 2361301 ttaccgcttt ccctccattt accgcaacaa caatctgtct gtttctgcgt ttatttctca 2361361 ttgaatccct ccagcgcttg tctagtaatt actctatgaa caagctagag gaagtagaac 2361421 tgtttagtga ttgtaggagc ctttgttttc ttgtgacact ttttcatgaa gcgctgtgtt 2361481 taatccgttc gctaaaacat ttgccatatc gtcgataaat gaatcgactt ccttcggtgt 2361541 aaccattaag ttgtgcccta aaggcgaaag cacctcgtga atgagctgcc gtttttcatc 2361601 ttcttgaagg gttccgacaa tacctaggaa cgattggcgc tgcttttgat cgggaagatc 2361661 gtcttcagtg agcactttct ttttcccaaa cgtcatgcct gccggaacaa gcgatcttga 2361721 tggcctgtta tccttcattt ctctgccaaa atgttttaat atgtagtcca ccgtgtcgct 2361781 ggcaattgtc acggcatcaa ctactgtcgg aacaccgata gcaatcaccg gaacaccaag 2361841 cgtgtctttg cttaaatctt ttcgtttatt ccccactcca gaccccgggt gaatgcctgt 2361901 atccgatatt tgaatggttg tgttgaccct ttccaccgcc cgcgccgcca acgcatcaat 2361961 ggcgatgaca aaatcaggct tcgattgctc aatcacacct ttaataatgt cacttgtttc 2362021 gattcctgtt atccccatta cacccggtgc aaaagcactg acaggcctgt aaccctcctg 2362081 tacgttttcc ggctgaagct taaacaagtg ccttgttacc aacagatttt ctactgccat 2362141 cggtccaagc gcatcaggtg tcacgttcca gttgccgagc ccaacgatca aacagctcgc 2362201 atcttttgag atattaaggt tttcaagaaa agctgagaat tcctccgcaa agacagcaga 2362261 gaccttctcc tgcatttccg aatcattctc cctgattccc tgtgcttcaa gcgttaaata 2362321 gcgcccttct ttttttcccg aaagctctgc gccttccttt gtaacatcaa ctgtgcggat 2362381 tttaatgccg ccgtgatcac gctctttttc aataaagcct ttaatttctt ttgtcggcac 2362441 agcctgctga ttggccattg cttccttcgt ttccactgcc aaatcggtcc gtatcaaata 2362501 ctgattcaca tccagctcac tctttttcat acaggggcct ccttcacatt aagtacctat 2362561 attgttgcca tttgctgaat aaatcatgct aaaaagagaa ccttcaatga aaaatacttt 2362621 acatttatat tgcaatctaa aggtgtgttt gatagaatac aatttgttct attgtgaaga 2362681 agatttaacc ttaagacact gtgctacagg ttgtatctta ggaggtgaaa cacatgccaa 2362741 acattaaatc agcgattaaa cgtacaaaaa caaacaacga acgccgcgtt cataacgcga 2362801 caatcaaatc tgctatgcgt actgcaatca aacaagttga agcttctgtt gccaacaacg 2362861 aagctgacaa agcgaaaact gctcttactg aagcagctaa acgtattgat aaagcagtga 2362921 aaacaggtct tgtacacaaa aataccgcag ctcgatacaa atcaagacta gcgaaaaaag 2362981 tgaacggact ttctgcataa tataaaaacg atcctcaata atggggatcg tttttttcat 2363041 ttctttttaa cagctgtaaa aggaacagtt cgagcaggag ctgcttgtcc tttttcccgg 2363101 ttttcatctc atagtccatg acggcaagct gttcaataat taaacggagc tcctcctctg 2363161 aaaaaagcct tgcttgatcc atcgccagct ttacccgaaa tgggtgaact tttagattag 2363221 aagcgatttg tttttgtccg tatccctgtt ccgcgaagta cttcgtctgc agaatcagcc 2363281 ggaactgatt cgaaataagc gccataattt tgatcggttc ttcattttgt tttagcaaat 2363341 cataaaaaat ttgcagactc tctgttcgtt ttcggttgac gattttattg atcagctcaa 2363401 aaatattttg ttcaaggctt ctagcaacaa gcatttttac atcatccagc gtaatttctt 2363461 cacgatctcc aataaacgtg cagagctttt gaatctcctg aaaaatcgat gacagatgac 2363521 cgttcacaag cagaaccaaa tgctccgccg cttccgtgcc gattgttttc tgctctgttt 2363581 ttgcaaggtt gacagtaaag tctgtcgttt cctttgcatt taattccttc gcctccatca 2363641 taaacgcgtg cttctttaac gctttcgtca gcttttttcg ctcatcaagc ttttcatacg 2363701 gagcaagcag gacaaagact gtgtaaggcg caggtgattg tatatatgat tcaagcgcac 2363761 tgacgttgtg ctcaattttt tcttttttct tttcacctgt taaaaaatat ggatttttca 2363821 caatgacaag acgccgctcc cccataaacg gaaacgtttc agcatctgca atcgcttgat 2363881 ccagcgggtc ctcttccaga tcaaaaacgg acagattgaa atcctttgtc tcctgatcaa 2363941 cgaccgtctg tctgatcctg ctgacggttt cttgcagcag atatgtctct tttccgtata 2364001 aacaataaac cggatggacc tctccttttt tcaggctttt ccacacatca aataccattg 2364061 ttgtacgact tcctctcttt catcatcccc ttctatccta aattgagttt gcaaaatagt 2364121 aaagaggaag cctgactgct gcttccccat ttatattaaa cgcctgttcg caagcccccg 2364181 ggacagcttg taaaaaggcg ataatcacca gaacagaaaa cgttacctta gcttctagat 2364241 ttttcaaaac aattccatta tacttaagtc agtcaggagg gataaagttg aatgattttg 2364301 aaaaaaacgt tcaaagcaaa cgaaatgatg ctgtagattc agctgttggt tttgttgtgt 2364361 ccttcggatt tttcgccttc ttgtttgtca tggcaacggt tattcaccta gttggttcat 2364421 aacagcgact gcccgggctg ctgatttctc ggcagtcttt tttagttcgt ctctgttata 2364481 tctgatgtat catatggagg atagacagaa aaggttccaa ctctgttttt gtatctatat 2364541 tggatcgttc cgttttgatc tgttcgcagc acgcggatag aatgtctctg taatagttgc 2364601 agaacttttt gatgaggatg atggtaccga ttgtttttcc cggctgagat aatggccgtt 2364661 ttcggctgaa gctgttggat gaattcttca ccggtagagc ctttgctccc atggtgcccc 2364721 acctttaaca catctgcttt tatattcgga aacacgttca tcacctcttg ttccccttct 2364781 ttctccagat cacccgtcaa gatccagctc ataccgcccg tctccatcca cagaacgaga 2364841 gatgaattat ttttgcttgc cggatcaggt gcttccggtg acagtacatg gaactgcaaa 2364901 tcctttattt gcaacacatc gcctcgcttc acctcttcaa ttgccactcc ctcttccctg 2364961 gctgcctgca gcactttctc atctttaggt tcagaaacga accctttcgg aatcacgagg 2365021 cgctttactt tatgatgctt cagcagaatc tccgcctctc cgatatgatc ttggtcagcg 2365081 tgcgtcagaa ttaaagcgtc aagctgcttg attcccttag cagttaaaaa cggaatcagc 2365141 accttttccc ccagtgaaaa cggatgctgt ttttcgcgcc aaggctctga cgagtaagac 2365201 aaagtgccgc cggtatcaat taagacacga ccccgctgat gcggagcacc tacaaacatg 2365261 ctgtcaccct gtccaatatc tatcatatcc acttctcctt cggaactaag acacggatat 2365321 ataaagagca gaaacatcac cgtgcagcaa atgcctccgg ttaccatcaa ctgcgacaag 2365381 gagcgttttt caatcgccat aagcaatagg atgatcgtga ctgtgaataa aaaaagcaaa 2365441 acaggtgcag gatgtgcgat cataatcgtg aacacatcaa catctgcaat gtttgtgatt 2365501 aacctattga tccagcttat caataaatca aaccagctga aaaacaatct cccaaacgaa 2365561 gcggaaagac ttaatagaag aacacctgct acagctcccg gcaaaataca gaaggtataa 2365621 aatggtacca tcaacatatt catcggtacg ctgatgatag aaaactgatg aaaatgatat 2365681 aggagaatcg gaagcgagcc cagctgagcg atgagtgata caattgtcag ctgccccaag 2365741 gaggttttaa cctgctgaaa aatagaagag gatagaatta aagaaaaact gacggcgaac 2365801 gatagctgaa aaccggcttc aaagagatga taaggattga agagcagaag gacgatgtac 2365861 gaaaggcaaa ttgcagttgc agagcggaca cgccatttga caagacttcc agctaagtaa 2365921 acacccgaca tgagagcggc gcgtagcact gaaggagcag cgccggtcaa catcacatag 2365981 agcggcagaa ataacagcaa cagaattgac gccttttctc tagttatacc aaggcggatc 2366041 atgatataaa acaaacctgc tgtcaaaatc cccacgtgga gtcctgatat tgccaagaga 2366101 tggacaacac caagcttttg atacgcggta agcacttcat cctccacgta aaatctgtca 2366161 ccaactgtaa gtgcctgtac aatccctgtc gaatcaggag gcagaaggct gtttgtgaat 2366221 gatatgatat gttttctcaa gctgagcacc ttgtacttga aattttcagg ttcgctgcag 2366281 ttttggatag acgtgacaga gtagttccaa tgaatatgct gccgataaag atactcgtta 2366341 taatcaaatg cacccggcac agttgcgtga ttcggttctt ccaatgtacc agtcaactca 2366401 catgacattc ctggttctat gtataacagc tgttcttttt caccagcaga ctgaatgcga 2366461 tacgcagcag cccatttttc cttatcaggt gtctcaacca tcatagacat acggtcgccg 2366521 tcaattttgg gaatagtgtc aatcactgcc ttgaattgat aggttccctg ccgataggaa 2366581 gagacattct gagaatctgt gactgcatac agtacaaaaa acaatataaa agagaagaaa 2366641 caaacaataa taagaaaagc gtgcctcgtt ttgattaaaa tgatgaggag aaagaggatg 2366701 aaaagaaaaa tagcggggaa ataagcggcg gcagtaattc cagccgttgc cgaagctgcc 2366761 gccataggca ataataagcg cgaattacgc attcatcaca cgtagctcgt gaaaagtgta 2366821 ttcgcctgtt catgtatctt tttcaattct tcctccgcta aaccggcatc agccaatttc 2366881 cctattagac ccgctacaaa tgaaagcttt tctctgtttt tcagatcaac gatcatttca 2366941 tcgagttcaa cctgttcaac agttacaccc gcctgttcaa ataattcctg cgcatacgga 2367001 tgtgttttgt aatcctcagc ataataaacc gttttgatac cagcttgaat aatagatttg 2367061 cagcattgaa tgcacggata atgcgtcaca taaatctcgg ctccatcagt cggcacccca 2367121 aacttagagc attgaagaat cgcattcatt tcagcgtgaa tggttcttgc gcaatgatca 2367181 tctatcatta agcatccttc atctgcacaa tgtacgccgc ccgcgattga cccattgtag 2367241 cctcctgcta tcatgcgttt gtctctgact atagtagcgc cgacagataa tctcggacat 2367301 gtgctgcgca gcgccaataa atggctttga gccataaagt attgattcca tgaaattcgt 2367361 tccacgttgt tccctccaaa tgttgtgttg cctgaccttt agtttaccta tcataatgca 2367421 tgaccgtcaa atcactttac tgtaatggaa gactttattt tctcaaatga cttttcacct 2367481 attcctgaaa ccttagtgat atcttcaatt gtttggaaac gaccgttttc ctcccggtat 2367541 gcaataatag cttcagcttt ggatggcccc acccctgaga tgccttgtaa ctcctctaag 2367601 gttgctgtat tgatattcac cagcgctccc ttccctccat cgctttggac agaccctccg 2367661 ccaccttgct gcactgctgt ttcctctccc tttttcggga tgtacaccac tgtcccgtcc 2367721 tgcagaatct ccgccaaatt tacttgcgct tcgtctgctt gttcactggt cccgcccgct 2367781 ttctcaattg cctgagatac tctgtcccct gttcgcattt cataaacgcc aggatgctga 2367841 acagcacctt tgatgtctat cacaattgtt tcgtttgact cgtcgttgtt tgcttcctgc 2367901 tttaccactg tattttctgt ctctgttggt acagcttgct tcaccggctc tttatttttc 2367961 cctgtggcca gaaagatcat aatcgctgtg aaaacagccg cagaagccgc taaaataatt 2368021 gctttcttat gctgattcaa ccaattcatc gtgcatgttc cccgctttcg tcatatttta 2368081 ttttcataac acatatggtt tagaggataa tagctcaaag gaggggaaac cattgaagat 2368141 aggctttatc ggcacaggaa atatgggtac gatccttatc gaatcattta ttgaatcaaa 2368201 agcggccgat ccctcaaaca tgacaatcac aaaccgcaca attgaaaaag cgttgcacat 2368261 aaaaaaccgc tacaacagca taaacgttac cgaaagtctc gaaaagctcg tttctgaaaa 2368321 cgagatgatt tttatttgtg ttaagccgct tgatatatat cctttactgg caagagcgtt 2368381 accttattta agaaaagatc atattctcat ttcaattaca agccccgttc aaaccgaaca 2368441 gctcgaacaa tatgtgccgt gtcaagtggc gcgagtgatc ccaagtatta cgaacagagc 2368501 gctggcaggt gtttctctcg tcactttcgg cacaagctgc ggcgaatctg caaaagcgaa 2368561 aatcaatgag ctgatgcagc atatctctca tccgctgcaa attgaaagtg acatcacgag 2368621 ggttgcatca gacatcgtaa gctgcggccc cgcttttatg agctatctga ttcagcggtt 2368681 tatagatgca gctgtttcgg aaacatcagt gtctaaacag gacgcgattt tgatgtgtaa 2368741 ggaaatgctt gtcggaatgg gaaaactgtt agaaaccgaa ttgtataccc tgcctgcatt 2368801 acaggaaaag gtttgcgtta aaggcggtgt aacaggagaa ggcattaaag cgctggaaag 2368861 cggtgtgcag gatatgtttc accgggtatt tcaaaatact catatgaagt acgaggagga 2368921 tatttccgca gtgaaaaagc agtttcatgt gtagacgagt atgtcatacg ttcgtctgta 2368981 ctgcaaaagc ataaaaaagc attttaaaaa accatcgttt taggaaacga tggtttttga 2369041 tttctgcgcc ttgaaaaaga ggcgttctga ttgtgctgat ggctcggtat ccgtaaaatc 2369101 agctgtcacg cgatggagct gaaagccgca gttcttaagc atttcttcgt attcttccac 2369161 cgggaacgtt ctttgctcgt gtgtctcatc aaaacgatca tacgcttctc cgttccacac 2369221 aaaaaacgac atatcatgaa tgacagaaag ctcgtcactt ccggcaaagc tctgccaaat 2369281 atagctgata tcttcgtcct ggtcagcaaa tgtgctatcc ggaaagactt ccgcaatttt 2369341 aaaagatgaa tgaacatcaa acagcaggat gccttcaggc tttaataccc gaaaaacact 2369401 tttaaaggtt tcgatcacat cattttttgt ttttaaataa tttaatgagt cacagcatat 2369461 cacaacagcg tcaaattgac cgtcaaagcc ggtaatctct ctcatatcct gctgaagaaa 2369521 taaaataggc tggctactcg ataccttttg ctgggcgaaa gaaagcatct cttcgctgag 2369581 atcgatgcct gtaacctcga agcctttttc ggcaagccgg atggagattt cccccgtgcc 2369641 gcatgccaga tcgagaatac ggcctttttc cgggagagat gcttcaatcc attttgtcca 2369701 ttgatcgtaa ggcgcgtgtg acattagctc gtcatacacg cttgcaaagc cttgataaat 2369761 cattgattca ttccaaagtc aagatctgcg agcggagcgt ctccccacag cttttcaagg 2369821 ttgtagtagc ttctttcatc cttgtggaag acatggacaa ctacatcgcc tagatcaacg 2369881 agaacccatc ttgcttcatc aaagccttcc atctttttga cttgaatgcc gttttcatca 2369941 gcttgatcct tgatttcacg ggcaatcgcc tgtacctgtt tatctgaatt tccgtggcag 2370001 atcagaaaat aatcagcaac cagagaaata ccttccatat ccagtgctaa aatatcctct 2370061 gcccgtttat catcgcaagc cgcagctgcg atctttaaaa tggacttttg gttcattcac 2370121 aaattcctcc tgttcagctg ccagacacaa gccagttata cgttaaaaat gtgtctggaa 2370181 aaaccggttg attttttttc ataagaaaaa ccattgtatt tttaatggac tgaatcagcg 2370241 cttgattcaa atctgtctca gcaagcttac gcacctcatc gacaccggga aatgcccggt 2370301 ttggctcaat gtaatcggca acgtaaatga ctttttctaa aagtgtcatg ccggggcggc 2370361 ctgaggtatg atacctaatg gcgtcaagaa tgtcttcatc ttgaacccct gcctctcttt 2370421 ggaccaaata agcgccgacc ggagcgtgcc agagctccgg attatgatcc aataaatgcg 2370481 caggcatttt ttcacgcgca ataatttgtt tcatttcttc tttcgggcgg aatttggcgt 2370541 aatcatgaaa gattgccgct atttccgctt ttttagaatc ggctccaaaa cgctccgcaa 2370601 gttcgatcgc cgtgttcatc acgccaaccg tatggatata tcggtgttcg gtcaattgct 2370661 gcttcacgca tgcaagtgcc tcctcacgat tcatataaac cattctcctc tacatacttc 2370721 ttcactttat cagggattaa gtagtcagtg ggcttcttgc ttttaaaccg ttcccttatc 2370781 atagttgatg atacctcaaa ttccggaacg tctgcaaaga gaagcggata aggggtttca 2370841 acatgaaaac cggggcgctt tactccaata aattgaatga ggttcagcag ctcgtccagc 2370901 ttataccatt tcggcaaata ttcaatcata tcagcgccga taataaagaa cagctgatca 2370961 tttggataac gctgcttcag taaagaaacg gtatcaaagg tatatgatgg cccttctctt 2371021 tccatttcaa caagctccag cttaaaggac ggattagatt gaattgcaag ctttagcatt 2371081 tccacgcgat gaaagctgtc ggtatagtct tcgttctgtt tatgcggcgg aatttgatta 2371141 ggcataaacc aaatttcatc aagccccgcc tggtacagca cctcattcgc cattaagagg 2371201 tgaccattat gcggagggtc aaacgtgcct ccgaaaattc cgattttctt catttcaacc 2371261 acctttaagg aagctcgatt tgtttatttt cctttgattc cttatataac acaatcgtat 2371321 tgccgattgt ctgcaccaat tgagagcggc ttccttttac aagagcttcc gctacatcgt 2371381 ttttatcctc ttcgcaattc tgaagcacgc tgactttaat cagctctctc gcttcaagcg 2371441 cctcagcaat ttgtttaatc atgttgtcgt ttactccgcc tttacctact tgaaaaatcg 2371501 gcgttaaatg atgcgctttt gaacgcaaaa aacgtttttg tttacctgtt aacattctgt 2371561 tcctcctaat tttcctatta caatagatct cattttttca atattaggct cttgtccagt 2371621 ccacaattgg aaagacaatg ctgcctgttc aacaaacatg cccacaccat cgagtgtttt 2371681 caagcctttt tggcttgctt cttttaaaag tgccgtctgt attggattat acacgatatc 2371741 acatacgacg gcactgctcg cggcacgctg taatgaaagc ggcacatcgt ccacgttcgg 2371801 atacatgccc acagacgttg tatggatgat aacatcatac tgctcaagac gttcttctgc 2371861 ttcttttatg cttaatactt ctttattgtg aaacgaggga gtagcttctg taagccgctt 2371921 tgctttttct aacgtccggt tgcaaatgtc aaattttttc ggggtatttc ggacaattgt 2371981 tgtaaaaatg gctctcgccg ctccgccagc gccgatcatt aagaatgaca gttcagagat 2372041 gggcttgtct aataccttca ttaatgactt cacgaagcct tccccatcgg tattgtatcc 2372101 gacaagctta tctccctctc ttctgaccgt gtttacggca ccgagcactt ttgcactctc 2372161 atcaatatga tccaaataat ccataatgga aaccttgtgc ggaacagtca cattgattcc 2372221 ttgtacgcct agagctctta ttccttttac cgcatcctcc agatcattct cttctacctt 2372281 gaaggcatga taatgtccgt caagcccgag gtctttcaat gatgcgttat gaatatcagg 2372341 tgacatagaa tggccaatag gatttccgat aaccccgtac agctttttca tacacctctc 2372401 cccttttctt aaattaatga acgccgaaca aatacatgaa cgccttttgg cgcgtatgca 2372461 gttacctttt tatcagcgtc atggacagta acccagccta acccagagaa aacgatatct 2372521 gtctttttgt cttttatcgt aaacgtatgg gcgaccaatt caggaaactc atccatttca 2372581 tctttacccg gaggtgtgag caattcccct gcatgctttt cataaagcgc gtctgcattt 2372641 tcaagttttg ttctatgaat catcagctca ttcggcatat agcaaataaa aggagatctt 2372701 tccccagaca cataatcaaa ccttgcaagt ccgccaaaat acagtgtttg ctgatcatta 2372761 agctggaatg tgcgaggctt cagctccttt ttaggagata atattttcag gtccttttta 2372821 ttgacataat gcgccatttg atggttgttg ataattcccg gtgtatcata aagcgatgaa 2372881 ccgtcatcca gcgggatttc aatcgcatca agggttgtgc caggaaattg ggatgttgta 2372941 ataatatctt cttcacctga cacttcttta ataatccggt taataaaggt tgactttcct 2373001 acatttgtac atccgacaac atagacgtct tttccgttgc ggtaatgctc aatcgcgtca 2373061 attacttctc tgattccctg gccgcgaccc gcactgacca aaaatacgtc aaccggtttt 2373121 aagccaagct ctttcgcttc acgcttcatc cattggatca gacgctctct tttcagtgac 2373181 ttaggcaaaa tatccgcttt attgccaact aataagatag ggtttccccc caccaagcgc 2373241 tgcagcccat taatccagct gccgttaaaa tcaaaaatat caacaatttt tacgaccaga 2373301 gagtccgttt ctccaatacc gtgaagaatg ttcaaaaaat catcatcagt taaggagaca 2373361 tcttgtattt cattatagtt tttcagtctg aagcaacgct ggcaaatcac attttctttc 2373421 gtaagcgatg caggcggcgc gtaccccaaa cctgttttgt cctcggtttg gatcgtaact 2373481 ccgcacccga tacaaacaac cttttccatt tcttactcct cccactgaat gtgccctttt 2373541 cgtttgagag cactcagtat tctgcgttcg acctggcggt taaagcgcgt aatgaatccg 2373601 tcagaggaag cgactggcac gaccaaaatc gtatggtagc cgtttcggtt tcccccgagt 2373661 acatcggtca gcagctggtc tccgatgaca acgcagtcct cttttttcag ctccatattg 2373721 cgcaccgctc tattaaaggc tttacccatc ggttttcttg ctttatagat gaatgggatt 2373781 ccaagcggtt ctgagaaaag tttcactctt ctttcgttat tattagagac aattgtcact 2373841 ttaatgccgt gttccttcat ttcttcaaac cactcgatca atcgcggcgt cgcgttcggc 2373901 ctgtcccatt caacaagcgt attatccagg tcagtaataa ttccttttac atttcgttcc 2373961 tttaatttct caggtgtaat atgaaaaata ttttttacaa actcgtcagg taaaaaaaac 2374021 ttttttaaca aaacccgcac ccttcccttt ttctttcttt caaaatgatt gtcgaaaaaa 2374081 atcgaacttg cgcctaaaga aaaactgagc aaaaaaattt cgacaaaaat tgggtttctt 2374141 caccaggtgt ggataaattt acacacacta tccactctta ttacatcact ctttagacaa 2374201 attataaaca cgatactcac aagttatcca ctttttggtg tggataacag aacgattgtt 2374261 cttatatgca tttcatggta gattaaagat aacttcaacc tcagatgaat gcaacttatc 2374321 attgtatgcg ttaaaatcat gaatgattcc aacttttaag gaggtgcctc tcccattaat 2374381 tgggttccta gcatgagaaa actgtctgat gaattactaa tagaatctta tttcaaagcc 2374441 accgaaatga atttaaaccg tgactttatt gagttaattg aaaacgaaat aaaaagaaga 2374501 tcgctcggac atattatttc cgtatcttct taataggaat ttgtctattt tttccgggcg 2374561 tatttccttt ttttactcag atgactgata ttatatcact ttggctgcgc gctttactac 2374621 tattttcagc aaaaaacacc cctaaaaaga ggtgttttaa agggccggtt attatgctaa 2374681 ccagtatatg ccgcccacaa caaggagaac aacaactaaa acaacaataa aagcgtatcc 2374741 atatgctctg cctgcgccat acatgtgaag cgcctcctta ataaggtttt ataacagcct 2374801 atgtaggaga aataaatcgg actaggcggt tgtccggctc aacgctgcag gatctgccca 2374861 tcttgtattc cttcatatac gatccttgcc cctttaggtg tcatatgatt tccagaagga 2374921 tctataagac cagattggat aagcgcttca tcagttgctt ttccgccgtc tgcttctata 2374981 aaatgcttcc agttatctac aagagggaca tccaggcgct tcgacacatc tcttgtaata 2375041 tcgttatatg agttgtgcca tttccttgct ccgccttttg gttcaaaagc agctgcttga 2375101 tatctggaat agtaaaacaa atgatgcttc ccattacctt ctataattgg gatacacgtc 2375161 attaagattg gcttgatccc gtgttttctg ctttcttcaa taaaataaac cagattttct 2375221 ctaaaacgct gcttcgacac tctcggtttc ccctcagtca gtatggcagc gtcattggtt 2375281 ccgaacataa taaacaaata cttcggtttt tgatccagca catctgtctg aaatcggaga 2375341 cgggcatcct ctgtcgtctg tccgccgatt cccgcattga gtatatcaag gttaccgcgc 2375401 tcagctgttt ttaatatatt gacccactgc tgtgcttttg gataatcgcg ataatcccaa 2375461 ttagagccac gcgtattact gtcaccaaat gctacaacgt cttcgtatcc ccttccctcg 2375521 catcctgctg taacgaacag cagaaggaaa aggatgataa aatgtttcat ctttacaccc 2375581 ccaaaagcct cactttaatg ttatacctct gtttctcttc gttcaatgaa gagtttttcg 2375641 ctatcactgt tttttcctat agttaacgtg tccccctcag tgaatatcat tctgctttca 2375701 ttgcggcgca gctgatgatt ttttaaaatt cccttctttc caatctgaaa aacacacaaa 2375761 ccaaagaaaa gaaaataacc tgaatccgca ctggaaacag gttatccgtt aaatcctgca 2375821 tttactttaa cttcgattta agcttggcct ttgtttttgg cccataaatc ccgtctgcag 2375881 ttaatccgtt catgagttga aaacgcttga cggcattcgc tgttttcggt ccgtaaactc 2375941 catctatgcc attgtttttg gctcccttat cagggtaaaa gtgaagtaca gctaaagcct 2376001 tttgcagctg gagaatgttt gtgccctttc gataaggcga agtgagcttt ataaccccag 2376061 acggcagagg atatgatggt gaagtttctt ttggaggtgt atccgaggaa gaaattccgt 2376121 ttagaaaaga gttccagtgg tccaagagtt tccgcggaca ttctttcccg gaccactttt 2376181 tgtggggaac aacacgattt aacggaatat tgttttcctt catcagcttt ctgatcagcc 2376241 actgggcatt tgatgttgct ttttcaaaat cgccgtcagc attttcacag atttcaatcc 2376301 cgatcgattt gcggtttcct gtcccgtttg taccgtctcc cgcatgccag ccgttttcat 2376361 ctatcgggag atgctgataa atgactgaat cgtcaactgt aaaatgccag ctttcggatg 2376421 tgttcgggtt tttcacaaac ttggcgtgca ttttcgcatc agcgcctttg gctgtattcg 2376481 ctgtattatg caccgtaata taagcaggcg ccatcgcata gccaggacga ttatcatttg 2376541 ataccggtat aaaatccttt tttatggtta ccatttctat ccctccctat taataagaat 2376601 gcagaaaaca gagagatgga cagccttttt tatgaggtaa aaaagaattg tgttcttaac 2376661 ctggttttca gttgaacagc tgaaatggca ccagttatac taatttagat gacggaggtt 2376721 ttgactcctg acatcaccta agttgggagt gaccatagac atgttaaaaa aagtaatagg 2376781 tatacttgtg attatcgcta tcatttcagt tggttttttt cagaaagaag cttggcttga 2376841 tgcaatcaaa gcaggaggga tgttttccgt tttatttagt atgctgctga ttgctgccga 2376901 tgtttttttc ccaatagtgc cgtttgcttt gattgctgct ttaaatggcg cagtgttcgg 2376961 gactgcaaat ggaatttgga ttacactgac cggctcaatg cttggtacaa tattgctgtt 2377021 ttttctcgcc aggtacagtt ttagagattg ggccagaaaa aaagttcagg cctatcctgc 2377081 catacaaagc tacgaggctt ccttcaacaa aaacgctttt accgctgttt tattaggaag 2377141 gctgatacct gtcatacctt cacttgtaat gaacgtgatc tgcgggctga gccaggttcg 2377201 ctggcatgtt tttttctttg cgtctttaat agggaaaatc cccaatattg ttgttgtcac 2377261 tattgcaggt gccaatttca ccagcaataa attattgtct atcagcattt acggtacata 2377321 tattctgatc atcatgctgg tcatttataa aaagttccct catcttctga aggtgccaaa 2377381 aaaataagga ggcttgttgg cccccttact ttttttctgt cgcatggcct ccaaattcat 2377441 ttcgaagcgc agcaaccacc tttcctgtaa acgtatcgtc tgttaaagaa cggtatctca 2377501 tcattagtga catggcgatg accggcgttg ccgtctgcag atcaagcgcg gtttccaccg 2377561 tccattttcc ttcacctgag gaatgcataa tgcccttgat ctgatccagt ttcgcatcct 2377621 tagcgaaagc tcgctcagtc agtcccataa gccaagaacg aatgacagaa ccatgattcc 2377681 acactctggc aaccttctcg tagtcaaaat caaattggct gttttcaagc acttcgaatc 2377741 cttcaccaat cgcggccatc attccatact caattccatt atggatcatt tttaaaaaat 2377801 gtccgcttcc cgcttcacca gcgtatagat aaccattttc gacggcagta tcacgaaaaa 2377861 gcggttccac aatctcccat gcttcatgat cgccccccac cataaaacag gctccatgcc 2377921 gtgcgccttc cattccgccc gacgttccgg catcgagata atggataccc gcttctttca 2377981 tttgattgta gcggcgaatt gattctttat aatgagagtt tccagcttcg ataatcatat 2378041 cgcctttact taataaaggt gatacatcac gcaaaacagc atcgacaatg ccatgcggta 2378101 ccataaccca taggatgcgc ggcgggtgta ataaagaaat gaactcttta agatttgttg 2378161 tcccctcagc cccgtatgct ttcagttcat caacagccgc ttgatttaca tcatatccaa 2378221 ccacttgatg attgcggtca atgaattgct ttcctatgtt tatgcccatt ttccctaagc 2378281 cgattaatcc gattttcata tctgttcctc ctgattgtct aaaaagcctt tactctttat 2378341 gttccctatg gattgtattg tgatacgcag aaaacaaatg gggcttacat cgtctgcgca 2378401 tgtaaatttt atttttcatg accgacggcg cctgccagtt ctattactga atctctttat 2378461 atccataatt atcgctttat ccttgattta ccatcagttt aagttaaaat atgggaagga 2378521 attcgatttt ttcagtaaaa agaaggtgac atgttgcaga atcaatctca tactcttatt 2378581 ggagttacga aaaccgctgt attcttttta tacgctgcac ttgcaatcat cggttttgca 2378641 atcgggtatt ttattccgca gattgcgaaa tgggcattat ccctcccctg gatccctctt 2378701 gaaggaccac ttcggctcat tacctctttt cagggatcta cagcttcatt tatcactgct 2378761 cttctcggta tgtgtgcggg gatttggttc gctcattctg ttattgcaat gctgctgtct 2378821 gtcaaaatta cagatcacac agtggaattc atcaaaggaa aaaaagtgca aacaattcat 2378881 tccgatgaca tcgctcttgt atttatggat cacaaacggc ttgtcctcct gggaacagcc 2378941 ggatatgaat tggtacggga agaaattgat gaaaaaccag taaacgttga gaaggccttt 2379001 agacagcatc attacgaatg ggcaacagat ggtgatccgt ttaaagatca atttcgccga 2379061 tggattcctg atgcaccaga cctatcgcaa ggcgcccatg ccttattaaa agctcgtcac 2379121 aaagcactgc aggacgaaga aaaagacgat attgaagaat tccgtctcga actggcacag 2379181 ctgggcatcg ttgtacggga cgaaggcaca cgccaatatt ggcgaaaagc agaaacctat 2379241 cccccgaaaa ttcagctcgg cgaaggattg taacaacaga ggctcaagaa agagcctctt 2379301 ctttactact gcacaataaa cagcactctg gtaccgtcag gatagctgct catttgattc 2379361 cctacccacg agccggcgcc gcgattatca gaaggcgtca catatcggac atcagcccct 2379421 gcaccgcctt cctcgcagac cgccatcggc cactcatccc ggtcatagcc cggcttggtc 2379481 gggattccct ttaaagattc ctcccgcctt ttgtctgctc catctctgtc aatggtacaa 2379541 atatctggat gtccctctgc aatcgcatcc ctaatatgac tgccggtttc cggataacga 2379601 gacagcggaa aatataacac tttgtcatac gaagatgcgc cttggatctg ttgcggaacc 2379661 attaaacaaa gaagaactgc tgcagcaaga aacaggcctg ccatccattt tttcatcccc 2379721 atccccccat acctttgttc atttcaatgt atgggcgctt gatgaagaat atttttaaca 2379781 tttgaagtta gtatgctgct taccaaagcc ggactccccc gcgagaaatt tcccggtaca 2379841 gacacagaca gcctcccggt cacatacatt tacatatagg cttttgccta catacttttg 2379901 tggaggtgac gatggtgaca ggtgttttcg cagcgctcgg ctttgttgtt aaagagcttg 2379961 tctttttagt atcttacgtg aaaaacaatg cctttccaca accgctctca agcagcgaag 2380021 aaaaaaaata cttagagctc atggctaaag gggatgaaca tgccagaaac atgctgattg 2380081 agcataatct tcgcttggtc gcccatattg tgaaaaagtt cgaaaataca ggtgaggatg 2380141 cagaggactt aatctccatc ggaacgatcg ggcttattaa aggaattgaa agctattccg 2380201 ctggaaaagg gacaaagctg gcgacgtatg cagcgaggtg tattgaaaat gagattgtaa 2380261 ttacaaaagg ggggtgcata cacccctctt taatacgttt caatatatat ggtgtcagaa 2380321 tccacaatgg taacttcttt cacgataaag ttaacaattg tttttttatc ttcaagagtt 2380381 aagttatctg caccgattga ttgaaaatag tcgatggctc tttttagagc attttcactt 2380441 gagctcgtat catctaggac tttcattttt gactggattt cgttacactt ttcagtaagc 2380501 tgattttgct ttttttgcag ttcaataatt tgtgctttga tttcatctat gtctaaatca 2380561 tcgtcatcgc ttaggctgat tagcgttaaa agacgcttgc ggcctttttt tgttttctct 2380621 atctcttttt caataagttc taattcatca gacaggtgat ttgattgttc agcctcttta 2380681 aaagaaacat acttttgagg atttgtgatg aatttaaaaa tttcacccca tacatgccgg 2380741 ttcaatttat tctcagacat ttcttttccg cagccgcggt cctttgcgcc agaataattt 2380801 ttccggcaag tatatacata gtagtcttta ccatgtgatt ttcttttctt ccctgtcatg 2380861 gtatttccgc attttccgca tctaaccaaa cccgataaca agtaattgtg agggctgata 2380921 ctcaagtgtt ttcttttact ttgacctaag agttcttgag cataatccca ttgttcagct 2380981 ggaacaattg ctggaattgt cacagtgatt tgttcttctt caggccttat tttaattata 2381041 gatttgttcc ctgcctgctt tgaaacatag gaaccctctg tatcatattt atactgtcta 2381101 tgttcaccct tataggaaga gttcattaat atttgccgaa caacctgcct gtgccatact 2381161 ttggcgcctt tttttgtttt aacccccatc tgagttaaat gtagagcaat accatttact 2381221 ctgccgaaaa aagggctttt atgatcggtg aaatagttaa aaatcatccg aatgattttt 2381281 gcttcctctt ctaatatctc aagagttctt ttctctttaa caaatttata gccatatagt 2381341 ttagaatctt taatgatcat gccttttttc attttttgaa gtcggccgct tgatgtccgt 2381401 tctttgattt tggctttttc aaattctgag attgccccgc gcattgcgaa aaacaattga 2381461 ccttctggag aattggcgta ttcaccattt acaaaaatca aaggtatgtt tcgctttcgc 2381521 aattcgtcat caatgattag ctgattcatt aatttccgag aaagacggtc aggatcgtaa 2381581 caaatgactt gacttataag tcccttgctt gcatcctccc tcaagcgatt caaagccgga 2381641 cgttctaaaa gctctcctga aaatccttca tctgcatact tcagcacatc tttagtccct 2381701 gctttcttta tacaggcctc gatttggctg tcgatgctcg atcccttgat cgcttgttcc 2381761 tcggtcgata cccttacata tattgctatc accctgaatc tccttcctat aaagttttat 2381821 taaataatga tagcaatcgt taatgcattt gtcagcttgc ggtccctcga tgattatcac 2381881 tttcataaaa tgcatcaccc cttgggtaat gctatgtaac agctgtttgt ccaaatgagg 2381941 agattttaaa ttaaactata gtgttattaa acgtttcaat gaatatgcaa aaaatttaaa 2382001 aaaagttgtt gtgacttttc tacactcctt taggtcctca atagaaaaga ttttattttc 2382061 tatgcctcaa cattcgctta ttatagtttt caatgattta ttattatttg agagtacaat 2382121 ggagtagtgt ttttcattgt tagatagtta atgacatttc actggtgtca agttcgtata 2382181 gctagacatt aataaaaaaa ggacacatat aaatatgcat cctttaacaa aagagtttat 2382241 ttatttccct gtttcagcaa attccttcaa cctattccct atttcatcac gaactctttg 2382301 gaaaaacgcc catttttctt cttctgtccc ttgtgctctt gccggatcat caaaacccca 2382361 atgctcacgt tttacatgtg gaggcgtcat cgggcattta tcagcagcat ctccacaaag 2382421 cgtaacaact aaatcagcat tgttcagaat atcagaatcg attatatctg acgtttgatt 2382481 agagatatct ataccaactt ccttcatcgc tttaacagca ttcggattta atccatgtgc 2382541 ttctatcccc gcgctataca ctttccactc atcacctaaa tattgtttag cccatccttc 2382601 agccatttgg ctccggcaag agttccctgt acataaaaag taaatgattt tattctccat 2382661 atattccacc tctacatcga gtgacttcca aagtattttc gttgaaacca taaagcaacc 2382721 ttaacaagtg ctatcatgac tggcacttct acaagcggac caattacggc ggcaaatgct 2382781 gcacccgaat gaattcgata tcaagcttcg cacttaaaca cagcggaatt tataatatat 2382841 gcttggacag ccgtaaaagc cgaactgaac aatggtatga ttttgctcat gaattttgcc 2382901 atatatatag acatgaaggc gataaaaaaa caatgcctgc aacttggact gattatttgg 2382961 attggcagtc caattatttt acatatcact tttgcattcc aacttgcatg ttgcgtaata 2383021 tcaaccttcc gtacatacaa tcacatgcaa ttgaaaatgt agcttggtta tttaaggtat 2383081 ccccttcatt cgctaagaaa cgtttaagca tttattacag gaaactgact caacatttat 2383141 ttagtcaaac tgttacggga aatttatgcc cccccttttt gtaatgaata atgaaatcct 2383201 catgcatttg cgcgcattga aaaaaacaaa aaaagacgtc tcccttcacg atccgatcgg 2383261 gcaggataag gaagggaatg aaataagcct gattgacgtt ttgaaatcag aaaacgaaga 2383321 cgtgatagat acgatccagc tcaatatgga gcttgaaaaa gtgaaacaat acattgacat 2383381 tttagatgac cgtgagaagg aagtgattgt cgggcggttt ggacttgatt tgaagaagga 2383441 aaaaacgcag cgagagattg ccaaagaact cggtatctca cgcagctatg tatcgcggat 2383501 tgaaaagcgg gcgctgatga agatgtttca tgagttttat cgggcagaga aggaaaagcg 2383561 gaagaaggcg aaggggaaat aatgcagaag aagccggatc tcatactccg gctttctcta 2383621 tttgaaagag ttatgaaaat catttttttc atcgctgata agctctccga gaaagacagg 2383681 caggatcgta acaaataact tgacttataa tcctcccgca ggcattcaaa gccggacgtt 2383741 ctaaaagctc tcctgagaaa atccttagat cggtatactt cagtacatct ttagtccctg 2383801 ctttctttat acaggcctcg atctggctgt cgatgctcga tcccttgatc gcttgttcca 2383861 cgatatattg ctatcaccct ggatctcctg cctataaagt tttattaaat aatgatagca 2383921 atcgttcatg catttgtcag tttgcagtcc ctcgatgatt attaccttca taaaatacat 2383981 caccccttgg gtaatgctgc gtaatacctg tttgtcctaa tgaggtgatt ttcaatgagt 2384041 atgaaaacaa ataaaaaaac cgatggtttg taccatcgat ctgttttcta tatcactagg 2384101 ccctcaatat agtaaatcta gctcattggt tatgaaagct tattttcatt acacactata 2384161 tattcatttg ttatcatttc tatacgttta tatcaattat ggtaaaaaat ggttacaaaa 2384221 acccaataaa cgtccaacct aactttttca tcttatttat taagaatttt aacctcttcc 2384281 ttgtgaaata aagaagcgat tttcatctcc aaacagttaa tgctatttca tcgggacatg 2384341 tctgttaaag tagccaataa atacattcgg atatccactt acaaccacga ttcaatttga 2384401 tccactacag atttctgagc tgacattaaa cagatagagt tataaaaatc tgtaccagtt 2384461 ccctttcaca attaggacat ttcggcggcg tttcggcata atgcgaacta atttattaat 2384521 gttcaacaac agaatttcgt ctattggcaa taaagaatcc acaaatcatt gcaagaatgg 2384581 ccatcgccca ccagaacgtt gagatcgcct gatcatgatc gatgataatc aaacgaatga 2384641 cagctgtgat gccaatataa atgaagtagc gaagcggaaa atgaaagtct gatttgaagt 2384701 atttgataat caaagcaatg aactcaaagt acatgaagaa tataagcagt tctccaagca 2384761 tctcataata gctgtccact ttgttgaaca gtgacttgta tacgaatagc acaatgtacc 2384821 aagtctcgct gatcagaagt gcgcttaagg ctaacgccag aaagaacaga cagacgttga 2384881 gaagcgcttg taacaggtaa ggcacctttt tgaatttgtt agaaaatctc atcatgttgt 2384941 ctcctatttc aatatattcg tggtttttat tctcagccta catcttggtg ttccaaaatc 2385001 gtagcacaat gtagtactta gaattctttt gtatactgtg aaactgtccc tgcatgcggg 2385061 acatcattcg cgcaatgctt ctttcaccga gtccgttgct ttccggtgtt atatctgcaa 2385121 gtttaatcgt attgctaaca tggatctcaa atatctcttg atccgataca aacgtgatac 2385181 tgattttttc ttccggatct gcgtatttca ataagtttga catcacatta tcaaatacac 2385241 gaccaagctc ctccaaattc acgttaatat aggtttccgg cagctcgcct gaaatatgga 2385301 cccgaaaatg ctcctgatga aggatagcaa tctgatctga tattagatcg tagatcactt 2385361 ctttcactgc aacggtctcc agatcggcct catattcctt gttcagcagg aaatacgcaa 2385421 acagattgtc agacaagctt tttaattgca gtgctttacc ataagcattg gctacatacc 2385481 gatctttgct ggcacccgct tcgcctccct cttttttggc aaactccaga ttcatgatca 2385541 gcgacgtcag cggtgtgcgc atatcgtgcg acatttcggt aaccaggctg cggctctcag 2385601 cttgcaattc ctcgatagct ttaagtttat ccaggaaagc tttccgcaga tcctcaatgc 2385661 tctttgcaat catcgctaat tcatcatgcc cttttatcgt catctcgtag tccagttcgc 2385721 ccccttcaag aatatgaatc tcttgatgaa tcgttttaag gtagcgaaga ctttggcgaa 2385781 ttccgaagag aacaatgatt aaaaagatga gggttgcccc gagcaaatcc aatgcaaagg 2385841 ccagatcata atatcgggaa gagtagaaac cgtcgataat gactcgtcct tcaccatcgc 2385901 taaacttgac aggatgtgaa tgattttgag cgtactgagt cagcttttcc tttccataat 2385961 ccgattcgga ataaatagaa tcatattgca gctcctgatc cttgaatatg gtgaggttaa 2386021 tgtaattttc ttttttgacc cactcgccaa acgcttttct atctgatgta gacaactcat 2386081 tttctgaaac gtacttgctg aatttttgaa tgtatcttgc tgactcctcg tgataatact 2386141 cttccgaact cagatatccc tcgatcagat catctgtgat cttttgcaac gtcagaaaga 2386201 tcacaccact cacaatcgca gcaaccatta tcagcaaagc cagttttttg gttagcgtaa 2386261 atttaagatg cgccaaatcg atatcctctt ccccattcag tttttatata aaccggacgt 2386321 gccggatcat cctcaatttt ggagcgcagc ttccgtatat gcaccatcac cgtattgttg 2386381 gaacagtaaa agtaaggctg tccccacaca ctctcatata tattttgggc agaaaatatt 2386441 ttgttgcgtt tgttcatcag aagtttcagg atacgatact ccagatctga caacttgatt 2386501 tgcttctcct ctttccacac ctcattaaat tcttcgctca ctcttagttt gcccccgata 2386561 agaaatgttt cttcctgttc cttcttttcc tgatagatag tatatctgcg taattgagca 2386621 atcactctag cgtgaagttc ctcttccgag aatggtttag tcatataatc atcgccgccg 2386681 gcgagtaatc cctcagtttt atcgagtgta ctcgatctgg ccgtcagaaa cagaatcggg 2386741 acgttagagg atttcctgat gtgctgacat gtttcaattc ccgaaatgcc tggcatcata 2386801 atatccaaaa taaccaaatc aagcgagtca ttcacaagtt gcaatgctcg ctttccatcc 2386861 ttggctctta gcacctcgta acctgcacgt gtaagggatt cctccaaaag atcaccaata 2386921 tcctcatcat cctctacgac taatattcga taggccatgt ctctctcacc tcatgattct 2386981 tgttgttatt tctcgtgtgt ccttactata tatcgttcat agtaataagt acgttataag 2387041 atactacgta aatcttaaca atttatgaaa gctgatgctc gccacaaatt tgtcacattt 2387101 tctaaaaaaa atgatgactc ttcataaatt gttaagattc ggtctttata tttatccatt 2387161 gtaaggctca agtttttcag atccgcacta cacattgccg tgataaatgg gaaaggagta 2387221 ttgatatgat tgtacaaaaa gaaggacgcg ggcaaccggt gagtctgcgg gaacgggttc 2387281 attttctgga catcgtacga ggatttgcct tgcttggcat tattattgtc aattattttc 2387341 tgatcgtaga ttcagtaaag ggattcgaaa tggcctccga tgacgtactg cataagctgg 2387401 tttcctggtt tgccgaaggg aaattcgtta cgttattctc cttcctgttc ggagtcgggt 2387461 ttatgatctt tatggatcga gccgcgcaga aggtagagag tcccaacaag ctgtttgccc 2387521 gcaggttatc tatcctgttg ggatttggca ttttgcacat cacatttgtt tgggtcggtg 2387581 acatattggc cttttacgcc gtaagtggct tcctgttact cgccttctat aaacgcacgg 2387641 ccaaaacggt gcttagatgg attatcgcac ttatcgtgtt tcaattcctg actcctgttt 2387701 tcacaatgtt gtacaatgtc atcaatactg cagggtcaaa aaacccgaat ttttcagagt 2387761 ttactttgtt tagccacagc agccttacct acatggaatc catcagcact cggtggacag 2387821 atatggtcac gatggctgcc ggctctttct ctatgatcta ttccatgttt ctcatgtttc 2387881 tgctgggcgt gtactttgtt aagatggaat ttttcaaaga catggaagcg aaaaagccta 2387941 tatggaagcg tatctggatc attagcacaa tcgcttttct aataacacaa agcagtatat 2388001 tactagacat gtttaatctt tctgagaata tgctgtggaa ggacatttcc tctgtcttgg 2388061 gtcaaaatgg cggcttaacc ggaagtatgt tttatatgag cacttttgca atgctgtttc 2388121 tataccttcc tcagctgcga ggccctatga tgatattcac caaagtcgga cggatgtcat 2388181 tgacctgtta tctgcttcac tctatcattg gaacagttct gttcctcagg tacggattcg 2388241 ggcttgcgga tcatattcaa tccgccggca cgttcatgtt cagtctggcc gtgtacttcg 2388301 ttcttatgag ctttagtaca ttgtggttga aacggtttag gtacggtccg atggaattag 2388361 tatggcgcaa gctgacgtac ggcaaagtaa acgggagtcc caaagcaact ccgctgcatt 2388421 cggaaaaatc tattcagaaa taaccccctt gcacagattg catgacttca aattagtgtt 2388481 gttgaatgaa gcgggcatta aacggacaga tttgatatat ggactagtta tttttatatc 2388541 atttaggctt ctttgggcta ataaatccac cagagtttac tcaatgtgca ttgctcatga 2388601 tcgaatctaa attgaatctt ttacgcatgt tcatagtcaa aggcgcctca ttcgactatt 2388661 tttgtaactt ttcgcaggaa aaattcgaga atgatgacaa atcccgcata cgacacttaa 2388721 tacggtagtg aacaatagta aattagggtt acatgcagct tgttttccaa tgaaacaaag 2388781 aaaaagaatc atacaaaaag acaggagaaa gcttttgaag tattttaacg ccaaatttac 2388841 cgcggaagaa agagcgatgg aatcactttt ttgtgaaaag gcctcgcaga gcagctcgaa 2388901 tgttttactg aacgactgaa ctctatattt tagcaactga gggagtgaac aatcatgaaa 2388961 actaaaaatg aaccaaaagt tattctggaa ctagcaaagg aatctgatct gccagaattc 2389021 caaaaaaaat tacaagaagc ctttgcgatc gccgtgattg aaacgttcgg tgattgcgaa 2389081 gatgggccga ttccatcgga caatgatgtt caggagtctt tcaatgctcc cggagcagtg 2389141 gtatatcata ttcttcagga tggtaagaat gtcggtggtg cagtagtacg tatcaacagc 2389201 caaacaaatc ataattcgct agatttattc tatgtatctc cagaatatca cagccaaggg 2389261 attggtcttt ctgcttggaa agccattgaa gcacagtatc cggatactgt gctttgggaa 2389321 accgtgacac cttatttcga aaagcgaaat atcaacttct atgtgaataa gtgtggattt 2389381 catatcgtag agttctacaa tgaacatcac tctaatccgc atatgcatcg caatggacgt 2389441 gaagatgaca agcccctact gaatgatgat gactttttca gatttgtaaa gattatgaaa 2389501 aaaaaggact aaacaattga acacggcgag atgccgcaga gagttgctgg taactttttt 2389561 atatttcatt atcagaggaa ggtaataatg atgtttaaaa ggtgttttga tccctgtctc 2389621 ataaacaggg gtcaaaacac ctttgaatca tcggtttctt ttctgacata taccacgccc 2389681 actagtccct caacatagta aaaacatatc atgagttaca aaagctttta ttcaaagcat 2389741 atgtttattt tatttatact tattttcatc atttttcaga attctggaca caaatcgggt 2389801 acctattaga ggccaaggaa ctctacattt cattaagaaa tacgtactca ttgccctgct 2389861 ttaattaatt ttaagccctc gcactatgcc cccccctgaa ttaagtattt gatgtaactt 2389921 tgaaattaag tttatgaaaa tctgtcacaa acccttattt cataacacat catttgtttc 2389981 agcttccctc gcgaataccg gattaatgct cggctttaag atagtcaacc aatctctccg 2390041 cactgttctt aacatcttct tttgaaagat gaagtgtccc atattgtgta aacgcaggaa 2390101 gaaaacgcat tcctatatag ttagcagtga cttgaaacgg tctgataagc tcgctgatcg 2390161 tgatattata ttctccgcct gcttgataat cagattcctg tgcgcctaag gagatagcta 2390221 agagtagttc ttttccatgc aatttagttc ctccagttcc ataagcccag ccatgtgtta 2390281 acacatcatc ttcccattgt ttgagtaacg cgggactgct gtaccaatac attgggaact 2390341 gaaaaacgat acgctcatga tctaacagga gctgctgctc tttttctaca tcaatgataa 2390401 aattagggta ttcaccgtac aggtcatgaa ccgtaatgtc tttctcttgc tttaaacgat 2390461 tcatccaggt tttgttgaca acagacgttt ccaaattagg atgtataacg ataactaatg 2390521 ttttcattag actgattatc ctttctttgc caattagtta ttatttttta cgataatgaa 2390581 ttgattctaa ttttaaaata gcaactttat ttacacctat tttatccttt ttcatgaatt 2390641 cagggcaact aattgggcac caaaatcaat gatgacttaa gacattgttt tgtagaaatc 2390701 cgatatacag aataatccat tatttagaaa atttctacct tttccctcaa tccttaccaa 2390761 tttaaactca ttaaggagat actttatcac caactttaaa taataatgga ataagtgcta 2390821 ataaaataat tcctacaacc aacgtagata ttattaactc cttccataca atcaaattct 2390881 ttaaaaacat ttgataaata actaatgagt ttactggaat gttaagcaat aagcccgtaa 2390941 gaagtccagg tgcatacttt ttcattacaa cagttgcgat aagatgtgga aaaatagcgt 2391001 tgataaccat agaacctaga aagccaatga aaatccattt tgcaatatct gattctggca 2391061 tatataaaaa accaaatgca gataaataag ccaacatagt tataacaatg acagcaaaat 2391121 gaaattcatt tgaagttact ggcttttgaa actttgaaga ttgttgtgac cactcaggta 2391181 accaaatagc ttcctcaata ttatgaagtg taatagcaaa acaaaaaaat gctacgaaat 2391241 aaaccaccta tcatttcctc ctcggtgcca caaccaatat ggtttggcaa cattatatta 2391301 catttgaggc tgattggata tggtgttaaa agagagaaga atctgcctta gtagttgctt 2391361 cttaattata tgtgcaataa cgtgttgtta cgtggcatgt catattcaaa tataataact 2391421 ctaaagcaaa caaagatacc tatatagttt ggcatcctct tttttagttc gagtccctct 2391481 atttattttg ggcacaaaat agacataatt tatattgact cattataccc atcacatacc 2391541 atacccctta aaccaatcag gattaaaatg ttttaaaaaa ggtgatcaaa gattaagtta 2391601 tggtctcttt tattttatgt atgctgtctt aatgcaaaac aacactggac accactaagt 2391661 caaatgcatt tcatggtact atagtcaaga cttgtccaag tcaccattat caaaatgaat 2391721 ttcatcaaac acttgaaaca tttattgaac gcggccaagt gtcataacat taataagaaa 2391781 ccaacgagtg atgaatcttt taatctttca ttttacccgc tggctcatat caaaggagct 2391841 ctaaccaaat tttaatagct gtcgcaccta ttaattgcgc taaaacccat tgcaggaatt 2391901 ttgtatttac tttttgccca actgatgcgc caataggaga agctattaaa ctagtaatca 2391961 taagaaccag agctggtaca aaaagaacct ggcccgtgat tacttttcca actgttgcgc 2392021 caatggatga aagaaatgta atcgcaagag atgaagcgac tgtgactcta acaggaatat 2392081 ttaaaatcga taacataatg gggactagga taaaggcgcc gccagctcct aaaatacctg 2392141 atacgccacc aatgataaac gctaaggaag aagccaacca tttattaaat atcacttcct 2392201 tatcttcgct atgttcttgt cctttctgtc cttttttagg tataaacatt aaaataactg 2392261 ctataatagc cagaattccg tatataaagt taattccttt ttcagatata taatgagaaa 2392321 agtaactccc caatacactc cctaaaagga tgctgcttcc catgtaaata attaatgttt 2392381 tatttataag accactctta cgataagccc aaacaccgcc gagtgtcgca aaaaaaactt 2392441 gaatagcccc tatccctgaa acttcatggg cagttaatga catcactccc actaaagaag 2392501 gaatgtacaa tagcattgga taattaataa ctgctccgcc aataccaatc attccggaaa 2392561 taaaggcacc aataaaccct ataatgaaaa gagttgtgat aaaggcaata tccattttat 2392621 ttgcctcctt tcataggaaa agggtatctt tctattcgat accctttcac attcattagc 2392681 ctttttgaat ccaaaatttc aatatatcgc cctcgtccgt ttgctctaaa aggtcatgtc 2392741 cgcctgattt agaccaggct gtaagatcat ttttggctcc cttatctgtt gcatgcactt 2392801 ctaatatttg acctgattcc agttcattca tcgctttttt tgttctgaca attggcattg 2392861 ggcatgccaa gccttttgcg tctaatactt tatctgattt catgttcttc tctcctcttt 2392921 ttagcagaaa cttgtgttac cgtattgcac agcggtttgg gccaatctcc atttcacgct 2392981 gtttttcttc atctgggctg attttcccca tgtttgtttc tcgaatctct tggtatgcat 2393041 ttggttgcgg aggcaaatga tctgttacta ggtgtctaaa ttctgtttca tccgcaatgt 2393101 tcaaaccatg gttctcgcta aataatgtac ttagttgttt accaacactt ccattctcat 2393161 ttagctcgtc aatgatcata aagtgtgccg gtaatacaat taaatccttt gataacgctt 2393221 tgtaacggct ataaagcgtt tttcttaaat ctcctaccca atcttctgcc ataccggcta 2393281 agtctggtct gccgattgaa tcaataaaca agatatcacc tgaaagaaga tactggtcat 2393341 cgacaatgaa agaagtggag ccaatcgtgt gccccggaga ataaatcggt tgaattttaa 2393401 tcgttgtatt tccaataata atgtcatttc cttcttccaa cggctgataa tcgaattcca 2393461 cttcttcagc atctttaggc ggtaaccagt aggttgcttt tgttttttca gcaatgactc 2393521 tgccgcctga aatatggtcc gcgtgaagat gtgtatcaaa tacgtgagta atcgttgcac 2393581 ccttcccctt cgcaaaatct ataaagaaat tcaccatacg tgtcgcatca ataattgctg 2393641 cttcaccatt ggaaatgacc atgtatgaca agcagccttt accgattcga acaaactgat 2393701 acatctcacc gccatctttt aaatccccga cttttaccgg ctctaaatgt tcgctccatg 2393761 ctttcattcc acccttaagg taggatacag aatgacctgc ttcagaaagc atttcggata 2393821 ccatgacgga tgaaccttct tttgcgcaaa cgaccagcac ttctttatca gaaggaattt 2393881 tctccaagat atcttctacg ccatctaaaa gatcaaaata aggaacattc aaatggtcaa 2393941 agtcatgccc ttctatcttc caatcactaa aatcattttc attacgcaca tccaaaataa 2394001 ataaaggttc tttgttaaag atttttttgt cacttctttt ggggtcattg cctttacggt 2394061 catgtttcaa tacctcctat atcaaatctt ttagcgggac taaaacgtta aggatacatc 2394121 agcatctttc gtaaaaccaa aaaaggtaac agccccgcct acttcgattc cttccataaa 2394181 atcatctttt gttaaaccca taacgtccat cgttatttga caaccaaatc atgcaactcc 2394241 catttcaatc agttaagaat agaaggcaca tttgcgttcc tacaaccttc tgcgacatgc 2394301 tcttttcctt gtcgcaatat tacagacttt ataagcatca aacagaccgc tatttgccgc 2394361 aataatcgct actcttgtac tcatctgttc atcatgcttt ttatttattc ggttttacct 2394421 gtccaatccc gcatacccgg gacaacatta ataacctttt taaaaccttg ttttttcatg 2394481 gtgcgggccg ccatttcact ccttcttccc gaatggcaga taatataaat ttcatcattt 2394541 tcgtttaatt cgttagcgcg cttttccact tcaccaagag ggatatgcac aactcctggg 2394601 atatgagctt tttcatattc ctctatctct cgaacatcta aaatgttaag agactcgtca 2394661 ctatctactt tctgtttgaa agcttctaat gaaatctcag gaattgaaga tgcattttct 2394721 gatgaatgct ctcctccttt tcgaagaaaa tgacgaagta tttctccctc tgcttcagta 2394781 cccagatatt catggcctgt actttttgcc catgcttcca gatctgctgt agaaccttta 2394841 tctgtcgcat gaatttccaa tacttcacca gcttttaaat ccttcattct cttcttcgtt 2394901 tttacgatag gcattggaca cgccaaacct ttagcgtcta gtacaatagt tgctttcatc 2394961 attttttcct ccttttctta tataggggtg ggggtataca aatatacaaa aagtttctca 2395021 ctgtaagtta acaccatgta ttcatacccc cttttatatt tgtgatgttt ttaaatcctt 2395081 gtttcttcaa tatttttact tgcctttaaa cttctcattc cgcttagcaa tgagtaaatg 2395141 agtaacatta gataaataag ttgacactgc cttcctcagc atctgccaaa taagctgcta 2395201 caccagcata gtcaatatca tctaatagtt ctttttcctg taaaccaaga agatccattg 2395261 tcatcgtaca agctacgagc tttaccccct gttcttgagc catctcaatc aactgaggta 2395321 aagtaagtac attatgcttt ttcatcacat ttttaatcat tttagggccc atacctgcaa 2395381 agttcatttt agataaaccc atcttatcag caccacgagg catcatcttt ccaaacattt 2395441 tttcaagaaa tccttttttc actggaatca gctcttcttt acgtaaagcg ttaaatcccc 2395501 aaaaagtatg gaagatcgtc acttcatgat cgtaggcagc tgcaccattt gcaataatat 2395561 aggctgccat tgctttatca taatccccgc taaataaaac aattgttgtg cgttttgttt 2395621 gttctgtcat gtttattctc ctaactaatt acccctgcgg gtatattaaa gtcaaaaaat 2395681 tttttcgaaa gatctgcttt tattcaactc tttaaatacc atagggggta taatataacg 2395741 catataaaaa ttcgtcaacc ttaggttgat gaatttttat cggctcttta ccaataagtc 2395801 gactgcttct tttactaaat tttgtgtgtc ttcgcctttt tctaaacttt cacgaacaca 2395861 atgttcaagg tttgtgctca caattaaacc catcgctcga tcgatcgcat tacgggaagc 2395921 tgctaattgg gtcacaacct ctctacaatc ttttccttgt tccatcatag tcaatacacc 2395981 tttaatttgt ccttcaatcc gtcgtaagcg gtttttaatc ttttgatcat actccatata 2396041 tcaatgaaat cctttctttc atttattttt acatttacat gttgccagtt cataactgtt 2396101 tacatggata cctttgcgct ttagaaaacg cactcctaaa tttaattcca cccggtcacg 2396161 agctattatg tgtattttat cacgtggaat ctctaaataa aaacgtttta gatacgcata 2396221 tgggatgttt aaaataatat tatccgaaaa attggctaca tcgttataat gacgaatatc 2396281 taatattgtg atgtccatag cctctaattt atctttatgg atacaagaga ttccggttat 2396341 aggataataa cgtctatacg ttgcaatgat aatcacaaaa ataagcagga atgcaataac 2396401 taaataattg atactattta caccacctta ttaactcttt gtttattcac aaaacaataa 2396461 tataccccca taggtatata gtcaagtgtg aaagttactt tctttgagct gatagattca 2396521 tttcgatatc cgcggattga aaaaatactt acattcgata atgccaattc tgctaaaagg 2396581 aactcgaata aagcaataag ccgatttaat tttaaatcgg ctttatttat caattactta 2396641 aaattagcac aagacacgct gcttggatat taaatggggt ttcattagca tggtactggt 2396701 tccccatgtt tcatgctgga tgtgacttta attattctag aattctccag aatatctgtg 2396761 ctaatcttcc gcagccactg catctgcttt ggtttcatga actgtaccaa atggatggtt 2396821 aggaggagca taaatggagt aaagttttaa tggcgtattt cctgtattaa ttacgttgtg 2396881 ccaagtgccg gcagggacaa caatggcaga atcatcatag acatttcttt gaaagttcaa 2396941 atgatctttg ctctttccca ttttgacgat cccacgcccc tgctcaatcc gtaagaactg 2397001 gtcaacgtta ggatggattt ccaaaccaat gtcttctcca ataccaagac tcatcaaagt 2397061 aacttgaaaa tgctttcctg tccataaagc agtacggaac gtattgtttt gttttgtggc 2397121 tctattgata tttacaacaa atggttttgg tccataatcc ttcaaaagaa ggtttctatc 2397181 ttcatatgaa gagcgcaaat cggcacctct gtgtactttc tccatctcat ttggaatagt 2397241 ccaataaaca gatcttccat cattatacat cggcacagtc acataataat aacattgagg 2397301 cgaaaaaggg ttatagtaca ttttttgatc cccgcaatta taaatttttg tgatagtatc 2397361 ctatgcattt attaagggag tgtgctaaat caagaaaact catattaaac acaaaaatga 2397421 atgttcgatc accgtttgat tcatggatga ataatttatc accgaccttg taatcgtttt 2397481 ctagatgttg aatttcacta gcctttgtta acaagacatc gaatgacacc tttatatgat 2397541 ggattatcaa aggtcgacga tcctaaatgg cttttgaaca tttacatagc acaacaacag 2397601 agtatacgga attctgttgt ttgtcccccc tatcccagct cttttagatt tatctctttg 2397661 gatgcgcctt gatggccagt ttttcagcag catagaattt atcccctcct gaatcgttat 2397721 agcatatttc aacgccgata gacttgcggt tcccagtgcc gtttgtaccg tctcctgtat 2397781 gtgggctcgc ttttagtaaa ccagtttata ttctttttgg gcacacaaca gaaacaattt 2397841 tccatatgaa aatctcgtaa ttttacacct ctttaacttg aaggaggatt tttgcatatg 2397901 tattttcata cccgtcaact accatctcat ccagcatata ttcctcatat gcattttccc 2397961 ctatttgcat tccatttctt tcaatgaact caatgattct ccggtacgcc tcttcagtat 2398021 ttccgcctat ttcatatcca actgcataca ggccttttgg ccgtacatga taatttatgt 2398081 tctctgcccc atcttttact tttatataaa agtaactgta attgtagaag tctttttcta 2398141 agatttgttc ccgtgcaaag attccgccta tcggatatcc ttcatctaat tcatattgct 2398201 gaacttcatg aatgagttct gaaatggctg ccacatattt tcgttctggt aagtttaatg 2398261 tttttcggct taacatgaat gtttcttcat ttaaatattc aaaagaaatt gaggaaaaat 2398321 cagtctcaag tgcttgttct gtaagcgtca cttttgtttg taagatcgtt tgcaactgct 2398381 taagctcatt tattttttta tcaatctcaa tagacttttc ttttagaaca tgcaggatct 2398441 tgtctggtgt ttttcctttt attagacact ttatttcttt taatggaacc ccaagctctt 2398501 taaatagact gatgacttga aaagtctcaa attgatgata ggaataatat ctatacccat 2398561 tttctttttt tatttccggc gagaaaagac caatctcatc ataatgaaat aaagtttgtt 2398621 tttttacacg gcagagcttc gaaaactccc ctgttgtgaa atacttctta acatcttcgc 2398681 tcataaaaac ctccttgact atacggtaac catatacctt atgatttgat tgtacttgaa 2398741 aaaagcttca agcgaaaagg ataggtaaaa agggttcaat tgagtaaaag gggaattcag 2398801 atgaaaaaat caataaatga gcaaaaaacg atattcatta tactattaag caacatcttc 2398861 gtagcatttc ttggtatcgg tttaatcatt ccagttatgc cttcttttat gaaaatcatg 2398921 catttatccg gcagcacaat gggttatctt gttgcggctt ttgccatttc tcagttaatt 2398981 acttcacctt ttgcaggtag gtgggttgac cgtttcggga gaaaaaaaat gattattctc 2399041 gggttgctta tattcagttt atctgagttg attttcggat tagggaccca tgtttcaata 2399101 ttttatttct cgaggatatt gggtggtgta agtgcggctt ttatcatgcc cgcggtaaca 2399161 gcatatgtag ctgatattac aaccctaaag gaaaggtcaa aggctatggg gtatgtttct 2399221 gctgcaatta gcaccggctt tattattgga cctggtgcgg gaggatttat tgccggcttt 2399281 ggtatccgca tgccgttttt cttcgcctcc gccatcgcgt taatagcagc tgtcacttcc 2399341 gtttttatac taaaagagtc attgtcgata gaagaacgcc atcaactctc atctcataca 2399401 aaggaatcaa atttcattaa agacttgaag agatccattc atcctgtcta tttcattgca 2399461 tttattatcg tctttgtaat ggcttttggt ttatcagctt atgaaacggt attcagcttg 2399521 ttttctgatc ataaatttgg cttcacacca aaagatattg cagccattat tacgattagt 2399581 tccattgttg cggtagttat tcaagtttta ctattcggga aattggtcaa caaacttgga 2399641 gagaaaagaa tgattcagct gtgcttaata accggtgcga tcttggcttt cgtgtctact 2399701 gttatgtcag gatttttaac tgttttgctt gtaacttgtt ttatttttct ggcgttcgat 2399761 ttgctacgtc cggccttaac cgctcattta tccaatatgg ccggtaacca gcagggtttc 2399821 gtagcaggca tgaactccac atacaccagc ctgggaaata tatttggacc tgctctaggc 2399881 ggtatactat ttgatcttaa cattcattat cctttccttt ttgcaggttt cgttatgatt 2399941 gtcggccttg gtcttacaat ggtttggaaa gaaaaaaaga atgatgctgc agctttgaat 2400001 taattcattt tctataaagt taagtcattt ggatgcaggg aatgcccctg gttaggcaca 2400061 ataagaaaag gtacttaatt tgataggcta catgttgctt gacgtgaata tagtataagc 2400121 tgagttttag caatatcagg ataccgggat aagaaaaaag gagaatgtag tatgagtata 2400181 aacataaaag cagtaactga tgataatcgt gctgcaattc ttgatctaca tgtcagccag 2400241 aatcaattat catatattga atctacaaaa gtatgtttag aagatgcaaa agaatgtcac 2400301 tattataaac ctgtcgggct ttactatgaa ggagatctag tcggttttgc aatgtatgga 2400361 ttgtttcccg agtatgatga agataataaa aacggacgag tctggcttga ccgatttttt 2400421 attgacgaac gctatcaggg aaaaggatta gggaagaaaa tgcttaaagc cctcattcag 2400481 caccttgctg agttatataa atgcaagaga atttatttaa gtatatttga aaataatatt 2400541 catgctatac gcctttatca aaggtttggt tttcaattta atggtgaact cgactttaat 2400601 ggtgagaagg taatggtaaa agagctatag atatccaagc ctccttgttt gctgagaaac 2400661 gtttgaactt cgataatgat tacctactta aactgcaaga tcattgttta aaaaagcctg 2400721 gatgaaaatt tcatctcagg ctttaagcat cttattagtc aaaatctcat gtgttttatc 2400781 cagatgttat tcttttttcc ggacaatttc taaataatta atatgccggc caactgtttc 2400841 gtgcacttta aaaatatacc catcggcttc tataacggac ccaactgcag cgtctatttg 2400901 ttgagtcata aaccagccgc ctattgtatc cacttcgtca cttgctaacg tcgttcccaa 2400961 taaatcattt acatcttcaa tgagcacttt cgaatctaag atatagtgat tatcatttac 2401021 ttttctaata ttaggcactt catctttatc aaattcatct ctgatttccc cgacaatttc 2401081 ttcaagaata tcttcagcag tgactaaacc tgaagtgccg ccatattcat ccacaagaat 2401141 agcgatatgt gttcgctctt tttgcatttt taccaataca tcatgaattg gaacggattc 2401201 aataacatgg ataacagggt tgatatgatt ttctaacttg aaatcctctt ttatcttctg 2401261 gtctgtgtca atataagctg acaaaaattc tttagcattg ataaaaccaa tgattgaatc 2401321 tttatctcca tttaggactg ggtaccttgt atagctctct gtcttaatga tcttaacaat 2401381 agtttcataa gaatcctcac tagaaatcgc tacgatctct cttctcggaa tcataatttc 2401441 tttggcgatt ctttcatcaa attcaaaaat attatttaca tatttcaact cattttgatt 2401501 gatttcaccg ctcttatagc tttcagacag taagatgcgc agttcttctt cagaatgagc 2401561 aagttcatgt tctgatgcag gtttcaaacc gaagagtcct actataaacc gggctgaacc 2401621 atttaaaaac catataaaag ggaacaggat gcggtaaaac caaataattg gctttgcagt 2401681 caaaagagtg atggtttccg ctttttggat agcgagtgtt ttaggagcaa gctctccaac 2401741 tacaacgtgc aaaaaagtcg ccatcacaaa agcaatcact aagatcaata catgtgagac 2401801 tgtttcactt acatgaaaat gagcaaataa ggggtgcaaa atcacttcaa aagtcgattc 2401861 tccgacccag ccaattccca acgctgtaac cgtgatccct aattgacaag ctgacaaata 2401921 ttcgtccaaa tgagtaatga cctttttggc tgatatggca cctttttttc cctctaatat 2401981 gagttggtca atttttgatg acctgatctt tactatcgca aattcagtcg caacaaaaaa 2402041 tgctgttaag acaattaaaa gagtaaagat tataaggtta atggttgtca atgatttgcc 2402101 ttacctagta aggcgtacac ctccgatgta aatatttatt gaataaacaa aaaacagtat 2402161 atataacatt ataagttcaa aagaacctaa aatcaactct gaatgatgta aataatcatc 2402221 tttttccgta tggagagtgg ttcccatagt cttcaactaa cgattagtgg cgttttaagg 2402281 cttaaaaaag aaagcaaaat aaaaacacac ctgaattttc tggtgtgttt caataatacc 2402341 caaccgtctt gatttattta atgtctttat aaagattttc ttttaaaatt tgaatcaatt 2402401 cggcctgttg ctttatattt ttgcggccat ttctattaat tgcagcaagt tcacagacaa 2402461 ttccagctga aatgaaaaac aataaacctt caaacatttt aaatccccca ctgtctaagt 2402521 gatagtcaaa tttgtttttt ctttttgcaa tacctgctta taatcttcct tacgctgata 2402581 tatgttattt aaaatgagtc caataatgac aaacagtgtt cctactatat caaaagcagt 2402641 tatgttatat cctttgatca ccatgattaa caatgtagta atggggacaa agttaataaa 2402701 taaaatccca ttaatggatg ataggatttt aatgccatag ttccaactaa ggagggctat 2402761 gatacctggt aaagtaatca taaataaaaa atcatactta attgctgcaa tcactttaat 2402821 actcggtacc gacacgtaac cttgcgcggt aagtatagct gtcatgattc ctgttatagc 2402881 tgtgccgaat aaacatgtca aagttgaata acgaagtgtg gaccactctc ggaatatctg 2402941 tccccccatt gtgtagacaa cccaccctaa aacaccaatg aatataaaga gtatcgagaa 2403001 tagatgatcc cctaatgaaa aaaagaaact tatattacct ttggttatga ccatcgaagc 2403061 ccccaaaaag gcaatcaata tactgatcat tgtgtatttt ttaggtttca catgtttata 2403121 tccccataga ataacaattg aaagcatcgg catgagtgcc tcggcaatgg atgctgtcat 2403181 aattccagac ttccccatca acctttgacc taaaaaaata agaacattgt atatagtaaa 2403241 cgccatcacc ccaaataaaa tgatccattt tgctttaccc tctaaatgaa atgatttctt 2403301 tccttctctc accaataata aaatcactaa cataatcgtt accacaccgt agcgaataaa 2403361 tgaaaaataa aacggatcaa caaattctaa tgcatgatct gcaactggaa acatcgcgcc 2403421 ccaagacata cttgctacta aacatgtaag ggcaccaatg aataattgac cttttttcat 2403481 tgaattcccc tccttttctt taaaattaca atgagaatta taaaaagaag taagcatcaa 2403541 gtaaaatgaa caaaagtgat gaaaaacatc attgataatg atactttaat gaagggggga 2403601 tcttcatgga actgcgagac ttacaaattt tcaaatgcgt agcccatcac aagagtatta 2403661 ccggtgctgc aaaagagtta aattatgtac aatctaatgt aactgcgcgg attaagcaat 2403721 tagagaatga gctcaaaaca cctcttttca atcgccataa aaaaggggtt tcactaagcc 2403781 cagagggccg aaaaatgatt gaatacgtta acaaaatttt gaaagatgtt gaagaactgg 2403841 agcaagtctt tctagatact gaaataccgt ctggaatatt aaaaatcggt acagtggaaa 2403901 cagtgaggat actgccgacc atcatagctt cctattataa aaagtatcct aatgtggatt 2403961 tatcattgca ggctggtcta acagaggaac ttattaaaaa ggtcatgaat cacgaattag 2404021 acggagcttt tatttcaggc cccttgaaac attctattct ggaacagtat gatgtttata 2404081 ctgaaaaact tactcttgta accagtaaca aaacgtttaa tatagaggat ttttcaacga 2404141 ctccgattct tgtttttaac caggggtgcg ggtatcggtc taggcttgaa caatggctca 2404201 aagatgaagg tgtgctccca aacagaatga tggaatttaa catcctagag acaatcttaa 2404261 atagtgttgc acttggactc ggtataacag tggtaccgga atctgctgtt atgcatctag 2404321 ctgtacaagg taaggtttat tgccacccat tgcctgagaa agacagctgt atctcaacaa 2404381 tttttatacg ccataaagat gcgtacctga caaattcaat gcgcagcctc ctaaagacca 2404441 ttgttgaaca taaaaatatg agtatggctt aaagtgattt ttctctttct atattctaac 2404501 ttcttaaata aaagagaagg ctcatctcca cttcgctacc cttattcacg caaaaaatag 2404561 agcagtaaac atgtgagtta ctgctctgct tcgtttattc accgttcatt tgttttacaa 2404621 tgtattcagc atcatttcct acgccttgaa gcaacgctga acctcgctta tgctgccaag 2404681 gcaaacctat aaagtacaat ccttctacag gtgaaacacc tctatgatgt atgattcgac 2404741 cttcttgatc caaaacacct tttatattta tccaacataa gggattcctg aaaccagtag 2404801 cccaaataat attgtttact tctaatgtag atgaatcttt aaaaatgatt tcattttgct 2404861 ttgcggcaat gactcttttt tttaagatga tctccttctg ttttattgca tgttttaatt 2404921 catgcccaaa tactggatca cctttctttt gaatgaattt gcctactatt gatgtatgac 2404981 ttgcatgtaa aactcctagt ttatcaaacc accaaaagat gcttcttttt ccgatcatta 2405041 aagggaaata aacaagttta ttactacaag ctaaatatgt aactctttct ttggataatt 2405101 caacagctat ttgagcacca ctattcccac caccaactac tagtacattt ccatatgcca 2405161 attgttttga attcttatat tgtgatgagt gtagttgatt aatattatcg gataaatcct 2405221 ttgatattga tggaatatta ggggtatgaa aaggccctgt agcaatgaca agattcttcg 2405281 tttgatattc ttcccgattt gtttttatta agaaataatt ctttattttt aggacactta 2405341 ttacttctgt ccgtaattgg attggaattt caaatttttt aacatacttc tttagataag 2405401 caacaatttc attttttgaa ggaaatccat gtttttctcc ttcaagatgc attccaggca 2405461 aagagctata cattcgagaa gtaaataaaa ctaatgagtc ataccgatct ttccagctct 2405521 cccccacctc atgactttta tccaaaatga taaacttttg atcggactgc ttaagataat 2405581 atcctattga gatccctgct tgaccagccc cgattactat agtgtcgtac acattatcac 2405641 cccgccaatt tcaaattgtc agtagacaga atctgcaaaa tcctagttga tctcctcact 2405701 ataaagttag ataaaaaatt taatggtgat ggtggtcacg ctgcttctcc attttgggct 2405761 gacaaaggat cgcattgtcg tggttatgcg cttcggtttc catttgaatg gttacgtgcg 2405821 taatgccttt atgctcaagt tcatgttcaa ttttgcgtaa aatattttca ctttctgaaa 2405881 tggtcagttg atcgtcaaca actgcgtggc aagaaagagc attcaatccg cttgtgatag 2405941 accatatgtg taaatcatga atgttttgaa ttccctctgt cccttcaatt gtacgaatga 2406001 tatcagagac atcgatattt tctggagttc cttccattaa gatgtgaatg gaatctttag 2406061 tcacattgta accgcttctt agaacaagaa tagccacaat gatactagcc aatggatctg 2406121 cccagcccca tccaaagaag atgataagta tggcagctaa aatggcacct acagagccga 2406181 gcatatcgct tattacatgt aaataagctc ctcttatatt cagattattc tttgtatctc 2406241 cgccactcat cataatccaa gcgaccaata gattcacaac taacccgatg atactaattg 2406301 taagcatgcc ggttgttgct acttttggtg gattagagaa gcgttcgatt gcttcataaa 2406361 tgatataaag agaaataaga attaaggcag caccgtttat cacagctgca agaatctcaa 2406421 atcgtttata gccgaatgtc ttattgtgat ttgccttttt ttcagctaat gtaaaagcaa 2406481 tcagggcaac cattaatgaa attgaatcac tcagcatatg gcctgcatca gataaaagcg 2406541 ccaggctatt tgttaaaaat ccacctatag cttctataat catataacct gtaatcatga 2406601 taaaagagat caataaaacc tttttatttg ctccttcatt atgattgtga cccataaaaa 2406661 actcctcctt acctaaagtt tttaatacat atgtatttat tatttcaaat ctgttatgaa 2406721 gcattctaac atgatacaaa taatatttat atatgagcat gtgttcatat ataaatatat 2406781 ctgctcttta ctgaaatgtc aaaatatttt tatagaaatc cacaatacct ccttaattat 2406841 tcttttataa acataaaaaa gcggagcaaa cacatggttt gctccgctac cctagtttct 2406901 ctatcctttt cttcaatcaa gcatttgagg gtagtattca actacaattt acctgttaaa 2406961 aattgggcct caccaagtcc aaaactccag tcagcattat cattttcaac aatagataca 2407021 attaaatcag ttgatgcgat accacactca gattccagtc tttcagctaa cagcctgtaa 2407081 aatttttgtt tcttctcttc cggtcgggat ttacttgtaa ctgaaagaac aacaagattt 2407141 ttagttcggt taaatcctaa cccagtatcc tcaataatca tatgattttc tggatgttca 2407201 tgaacaattt gataacggtc ttgttgaggc acatcaaaag cctctactac aacattgtga 2407261 gcgacatcta aaagtttttt caaacttgat tgatctcgcc cttctattaa gtcaaaacga 2407321 agtaatggca taaaatcccc tccttctact acaacagtct ttttaatttc attcgttaat 2407381 gtgtcagcta tttccaagca gctgctacat ttagaaaata aagtaatttc ccaataaccc 2407441 cttcattctg gtgttagtca agcctatgtt atgatgtgta tttccatagg caatatacag 2407501 aatcaacttc gagtaattaa ccattttttg aaatagcttt atcacttact ttagaaatca 2407561 tttattcttc taagctttag tttacatgaa gctctgctat catatataat tcaaaattaa 2407621 gatggaagac atctcaaaat cagatatcaa ctatggagga ctagatgaat attcagttgt 2407681 tacaggtttt tctcactact gctcgtgaag gcagtatttc caaggctgct ctgactttaa 2407741 attatgcaca atcgaatgta acgaataaga tacaacaact agaaaacgat ttacagacaa 2407801 aattattcta tcgtcatagt cgaggaatca cacttactcc cccagggcaa attcttgttt 2407861 cttactcaga gaaaattcta catactattg aagaagctag agcagccatg ggcgaatcat 2407921 ccgcgccttc tgggccactg cgtataggat caatggaaac aacagctgca gtttggcttc 2407981 ctcaactcct tgcacattat aataacctct atccaaatgt tgatttgaac ctagtaaccg 2408041 gccctacgga acaacaaata caagcagttt tacattatga gttaaacggc gcttttattt 2408101 cagggcctat tgaacaccct gatttagttc aagaaaaggt attggatgaa gagatggttc 2408161 ttgttacaag tgcttcacac cctgtgattt cttccattca ggatgttcaa acacaaacaa 2408221 tgcttgtatt ccgtaaagga tgctcataca gagcaaagct caatcatatc ctgcaagaag 2408281 aaggtttatt acctataaaa ttaatggaat ttggcatact tgaagcgatc attggctgtg 2408341 taagcgccgg cttggggatt tcactgctgc ctcgttcaat cattgcttcg catgaaaaag 2408401 aaggccgcat ccgcagccac actatctctg acaaatattc ttttgtatca actatgttta 2408461 taaggcggaa agacacttta attacccctg ctttatctgc ttttttaacg catatgaggg 2408521 atcattttca gataaagagg ccagatcaat cgtaaataaa tggatggaag gcatgcttcg 2408581 cctcaaaata cccctgatca gttgtctgat ataaaaatat aggcgcatct caatgtttgt 2408641 atagagcaaa aaagcaaact tcggtatgta gtttgctttt tcttcgtgat tttgcactct 2408701 gaatcgtgaa acctagtcga tattaggatg tagattttcc tcattcaaag aattttgaac 2408761 gaaggtcatt gccctagaca cttggttgcg tcttgaagtt aaaggctgac tatttcctaa 2408821 agcgtcaatc gctctcacaa ctattaaata ttcacctaca gatttcgggt gacaacggga 2408881 agattgatat tttcggttgg acaggggcag aacatccaat tgtaacagtt gaagtatcca 2408941 ctgatggagg agatcctgca gatctgagtg atattgctgt tgattgatca acttgttttt 2409001 gttcggaata tactcagtat atagccgcat attcctcctg caatagctgg aatgagccac 2409061 cccagcccta tgttatacat aggaagaatc tgagtgaaaa tacgattcac aacttcaatt 2409121 tttattccag ccgccttcaa accgtcaaat aggctgatga tgaatgcgaa taataaactg 2409181 ccttgataca cttctgtctt ccctttaaat acagaatgca aaaacgttaa aaatattaag 2409241 gaaatcgcga taggatacat cgtcagtaag acaggcattg acaccttaat gagctgggtt 2409301 aatcctatat ttgcgacaag cgtactaaac actgataaaa cgacagcaat ttttttataa 2409361 gaaatgttcg gaaataattc atgaaaaaat gaagaacacg ctgtgatcag cccgacactt 2409421 gtcgtcagac acgccactgt aatcattaag cccaataaga ttgaaccata agatccaaaa 2409481 taataggatg aaaccttagc caaaacctct gctccatttt ctaaaatccc cagttcttca 2409541 acgctggaag cccccatata ggaaagggct gtatacataa ctgctaagag tacagctgca 2409601 atcgcggctg cttttgcaca aacaactatc agctgttttt tggtagaagc tccttgttct 2409661 ttcaatgcat tcacgatgat aattccaaaa acaaatgcta caagggcatc cagagtgagg 2409721 tatccttcct gaaatccttt aaaaaacgct tgtgatgtgt acccttttga tggtgcttga 2409781 atggttccaa ttgggcgaat aagagctacg gctacaagca atccgataaa tgtcagctta 2409841 attggcgtca aaaatttacc aactatatca atgatttttg aaggattgag tgataacaag 2409901 catgccaatg cgaaaaataa tattgtaaat atgatcaatg agacagggct tgcatcattt 2409961 gataaaaaag gttttacccc aatttcaaac gatacgtttc ctgatctcgg gatagcgaaa 2410021 aaaggcccga ttgccaaata gagaatcgtc gtaaatacaa tgccaaacac cgggtgaaca 2410081 cggctggcta acgactgtaa gttttgttta cccgaaaaaa caaatgctgt tatagccagt 2410141 aatggcaatc caactccggt cactaagaaa cctgcattag cgacccatac atttttcccg 2410201 gccaattgac caagcatagg cggaaaaatg agatttcctg ctccaaaaaa caatgcaaat 2410261 agcattaatc ctataatgat gatataggaa gcagacactt tttttgacat tatatatcct 2410321 ccgattaaag tagacacttc ttgaatagcc aggaaacatt acagatgcta tttgcactgg 2410381 cacagtgttg attccaaaat aagcttgtgt cagttttata tatttttatc aagttaaata 2410441 aaagcatgat cattttgatc gtttccgata tcggttaaaa aaccaattgc accaaaacca 2410501 tataaacaac ggttcccccc gctatggaaa gaagcatatt tttcttccac aagtgaagca 2410561 gtacaacagc agctgctcca accaattcag gaatgccatg acttccagaa agtagactca 2410621 catctttcaa acaataaatg actaaaagcc cgattaccgc tgatggcagc actttaccaa 2410681 gatactgtac atatttcggt gtcggtttgc cagacgggaa aatcatgaat ggaaggaacc 2410741 gtgtcagcat tgttccaagc acgaccattg cgatggtgat catttgctgc gtcatagtca 2410801 tcgtcatacg gaaacctcag ctttctccaa tggttttctc agaacagtca gtacccctaa 2410861 aatggcgagc atagcaggaa taataaattg gtttccgcca aaaaggataa gactggctac 2410921 tgaaagtcca agtcccgtga gagcactgta atgctttttc tctttcatcc attgttctat 2410981 gaatatcaca ataaacagag cagtcatcac aaaatcaagc ccttcggtat taaacttcac 2411041 gtacgaccca aaaatacctc ctatcgctgc ccccgcgacc caatataaat gattaagcag 2411101 tgtcacaaaa aacataaacc agcccttatc aacattcgcc ggaacattag cggtataatt 2411161 gatagaaaat gattcatcgc acattccgaa aatcagataa agctttttct ttccagtccc 2411221 cctgtactta tccaacatgg aaattccata aaacaaatgc cgggcattga ccattaacgt 2411281 caaaaaaaga gcattcatag ggttgaacgc accaagtaaa aaattcgctg caacaaactc 2411341 cattgagccc gcaaatatca taaaactcat gatgattgga tagattgcgc taaatcccaa 2411401 agaatgcata aagatcccat aagctatccc caaaaataaa aaccccgcaa aaatcggaat 2411461 ggtatatggg aatgcagaac gaaatgcagc ccatatttga cttctcttat tcatatgagt 2411521 gtttatagca ggagagctta aatgtaacga ttctttattt ttattcaaat caacaacctc 2411581 ctacatttca tcaattggca cactgacagt tcttttttct gtactcatga ctatgcttgt 2411641 gtcaactcca ctaatagcag ggttctgcat taatgaatca atgataaaat tccgataact 2411701 ctccatgtcc ttcgccacaa tcttaagcat atagtcatgg cttcctgtaa gtgtgtagca 2411761 ttcttgaacc tgtgggaatt tgtttatatc ctctaaaaat gaatgaattg tctccctatt 2411821 taagggtgat aagttgatga gagctagtgc tgtgacttcg attccaagtt ttttctcatc 2411881 aacaatagtc gtaaactttt taattatacc tgcttctact aggttctttg ttcttgcaag 2411941 gcaagctgat ggtgaaagcc caattttctt agataaattt aaatttgata ttgaagcatc 2412001 ttcctgcaaa tctcttaaga tggccttatc agtttcgtca agcataatac ccatttcaca 2412061 acccccaata caacttaaca gaattatatt tcatacaatt taaataataa cgaattttta 2412121 ttcgttaatc aaatattatt taaatttaaa tccttttaaa gtattattca cagaataaaa 2412181 ttatcctcgc gattaactca taatgaaatt aacttacatc agaaagaagt catgggagag 2412241 ttatgtactt gtgtgacttg ataccaacat cataagaaac ttatcagaag ccaaaaagtt 2412301 attgcggtct caccgaaaat tgaatttgcg gtgccctatt gcctttttcc gcgaacgaaa 2412361 attgttaaaa ttcgcaaaac agaaagtcta ctctattatt attttaaatt cgtcctttag 2412421 ttcttcttga gcctcttgta taacttctaa tacatcgtca gcgtatgaac ctaaaaatgt 2412481 attgctgaac tcaaaatttt tcaagactaa agtgagcggc aaatccaccc accctgtcag 2412541 gcaatcccat aaagcgtcta aatttctccc atagtagtct gggaagtcta gtttatcttt 2412601 taaatcatca tgtaaaactt ctatattttc aaagtctctt ccatctatta ttatttttct 2412661 cattagaaac tatgccctcc attattttat cttaacaaac gtttactatg taacagctgt 2412721 ttgtccaaat gaggctgaaa acaaataaaa aacaccgata ggatgaaact attggtgttt 2412781 gcaagacatc ttcatacccg gtaggcataa ataatgctaa actttgtttt taaaaagcta 2412841 tcatatcaaa tttttatgtt acagctttta ctatcgttta atctaattga ggagtaaaac 2412901 aagatatgtt tgaaaatcac atatccccta aaaattaaaa actaatcggc agttcttcga 2412961 gtgctctcat cagaaaattc cctttccatt tcatttgttt cttttcgcct tttaactgta 2413021 tatttggaca gcggcgtaat aaggtggaaa tcgcaatctt tgcttctaag cgggctagct 2413081 gtgcaccaag acaaaaatga ttgccatggc caaaagcaat atggcggttg ttctttcttt 2413141 caatatcaaa tatgtcggca tttggaaata tcttttcatc acggtttgct gatgctaaag 2413201 aaatgatgat cacatctttc cgtttaatct cctgcccatg cagtataaac ggttcagccg 2413261 tccagcgaat tgtcgttagc tcaacagggc tgtgaaaccg caatgcttct tctatggctg 2413321 aattcatcaa gtccggctgc tggcggagct tttctagttg atcatggtga cacatcagag 2413381 catatgtcat attggtgatt aagtttacgg ttgtttcatg acctgcaacg ataagcagca 2413441 taatcatcga gtacaattct tctgtactta attgtgtgcc ttcactttcc gcttgaatta 2413501 atgcactgat taaatctcct gcaggttctc tccttttttt gcgaactaag gattccagat 2413561 attcaacaaa ctcccctaac aagtggtcat tctcctgaag tctttcaggg gcatctgaaa 2413621 aatcaataat tgcttgcgac catactctga atttttgacg atcttccaag ggaatgccga 2413681 gcatttcact tatcacgata atcggcaatg gaaacgcata atcgtctact aggttcatga 2413741 atttgttggg ctgcacttta tccaataaag aatctgcgat atgctggatt ttgtcttcca 2413801 actgcaaaat catccgatgc gtaaatgctt tttgaacaag agttcgcaag cggttgtgat 2413861 cagggggatc tgaattaagc atatgttttg ttaaagtctc ttcattcttc aatagagcag 2413921 gacgtttttc ttttgcggta aatacatttt catagttttt ctttaatttt tcattcttta 2413981 ataaatgtat tgcatcatca tatctcgata tgagccagcc tttccccaga gctcctaaag 2414041 ataatgggta gagagcctgt gattttcgca attctttata aaattcatac gcttcatctt 2414101 taaatgctct cgaagacaat tgactttccg tcaaaatggt tacactcttt ttttcttttg 2414161 aagacattca ttcgacctcc atctttgaaa ggttatgata atctttaaat ataaaatcag 2414221 gacgatttgt aaaatgatcc attgagatca gtattcatga taagggccaa aatgccgtcc 2414281 ccgcattttg aaataaaaga tatgagacag tcattaatca ttttgctgcc taaactcttt 2414341 ccctgataaa atggcgaaac tcctaatact tctatgccgg ctcttttaag gatttggaaa 2414401 attttttagc cccattttga ttaatgttat cccccctgct gctatataat cgatcaagtt 2414461 taatgtcggg tttatcacga tgttttaata gagcggcaac aaccatttca ccattctgaa 2414521 tgccaacaaa aaagaaatgc tttttaaaat atgctcttgt cagtacttta tgcatttcaa 2414581 aaataaatga atgatctttt tttcgcgttt tacgagtaaa tccataaaag gatattgatt 2414641 gaaagattga tggaatagct ttgccacttt gcttacttca tctgctcttg cttgtcgata 2414701 aagaaacatt gatgcacctc ctctgagcag taaagcagga aatcgaatta aagcgccctt 2414761 cctattggaa aggcgcctgc cgttttactg tgccaaaatg tttttcatca gtgagttttt 2414821 ataaaatcat ttattaattg atcagttgtc aatattgtgg caaattcatc atgcaatgta 2414881 gctagagata tattatgaat agtcgccgca tcataatatg tatcattttg gtctctcatt 2414941 ccgaaggctg ctgttgcatc tgaaatcagg tatgtatcaa accctaaatt accactcatt 2415001 cttgtggtgg ttgatacaca gtgaggcgtg gttaaaccag ttatgactac agtggttatt 2415061 tcatttaatt ttaagaattc ttctaaattc gtaccaataa agctgctatt tactgtcttg 2415121 gttataatga cttcttcatc cataggctta actatttcct ttattgcaaa cccttcattc 2415181 tttggatgga ataaagaatg aggtttatca gaagtgtgtt gtatgtatat gactgtccat 2415241 cctttttctc tccataattc tagtatttta ctaatgtttt cttccgcctt tacgttattc 2415301 cgttcccccc attttttatc atcgaaggct ttttgtacat ccacaatgat taaagctttc 2415361 ttttcttcca caagataccc tcctacgtag aatttctatt tattactaca ttctaaatac 2415421 aaattttact tttgtacaat tgtttaatga tgaatttcaa atgagcgcct tctttattgg 2415481 aaaatgcgtt ctatactgca actgtgccca agccgttaac cttcaaatct aatctgagaa 2415541 tcactggctc tacagagaat aataaaaaac actctaataa cgagtgctga aatgaaaaac 2415601 tattgattta gaagccattt gatacgctca gctgaaatga tgtagtggag tattataaga 2415661 cataaaaaga caatactaac tggttttaaa taactaaaat aaagcgctgc aacagccatt 2415721 gcaaagatca ataattcaat aactaacctt gttactccgt ttacagctat tacagtttgt 2415781 ccgcttcgac taggatcatg aggtactgca aatacagacc agacaatcat aactgcaata 2415841 ggtaaaacca aagttaaaac atatttaaaa taaccattaa agcttatcca agcatacacc 2415901 cctaaggaga ttagtgcagc aatttcaagg gtgaatctta aaagtaaatt agtctgattc 2415961 agtttttcca actcctctat aaaaaacacc cccgcaggag atgctctttc tctgctttat 2416021 ttcagcgtat aaaaactttt ctgttcttcc tctttagatt ctattgtagt tttcggcgag 2416081 attacctcta cttttgaaga gatgataccg actgctgctg ttaccaatgc tccgataata 2416141 gaacgatgat aagtataatg aaatatgaca acttttcccc tcctattcag ttaattatcc 2416201 aaataatcag gaagttgtct acaatttgca gaatttgtcg aacgaagtaa agattatacc 2416261 tgggaggctt tactcattgt atgaattaca gtaaataaat tgccttccct tttgagaaga 2416321 cgttccaact cagctagact cttccaatag gcttcctttt ggcgcagctg cttttattca 2416381 aaaattgagc aacacctgaa tgtttcattg gaatttctga accatcgatc gctgctgaat 2416441 ttgttgcaaa tgcatacgta ggagtagtcg aatggtggtt gaaaaatgaa atgccttccc 2416501 cacctcgagt gatggcagaa aaagcggggg ttttgttaga gaggaatcta tagatatgtg 2416561 tatcgaagat ttgacagcat taaaaattat acttacatcg ttgggaacag gccaacaata 2416621 aagcggaaga acgttgtcat ttgaagtggt ttggaataaa aatgattcga atatgttctt 2416681 atcattgtaa acgaacaaaa aaagaacatg ttttgaaaaa agattgatca aaacatcttc 2416741 ttatatgttg tcatagcgta actttttata aaaaggttaa ttacattttc ggggcttcca 2416801 aaccaaattt tgcccattct tcttttgctg gaccataaat acctggaaca gttaaacctg 2416861 cttgtctcat aagaacagtc atttgtcccc gatggtggtt ttgatgttga attaaaaaca 2416921 tcaaaagtga accgttaggc atttgttgtc caataaagtt gatacgttct tgaagtgtat 2416981 ggtcagtcca ttgggttttt aatgcctgta caaatgcatt actggcttga tgatagctgt 2417041 cagctataaa ctgagcagaa gttggaacag gataatcttc agctggggct tggaacgtta 2417101 agtctgtgtt tgaggtaatg atgccaatgg cagcaacagt atgccaagca atacggccta 2417161 gagtccaatt ttgtgaagtt atttcttgtt taagtgattc atcagtcaga ctatttaata 2417221 gtttctgtgt agcatctgct tcgaactccc aagatttcaa aaaatggtct aaggtttgaa 2417281 acacaaaaat cctccttttc attcttttgt tttttcaatg tgcttatagg ttaattataa 2417341 tgcctccttt cgttaaaaag aacaaaaatt tcggacaaga ataatcatag taaaatgcgt 2417401 agacattctt aaacgtaacg atttacgcat ctttttacaa acatctgact acttggtctc 2417461 cattgtcagc gagaatcaaa tatcatatga agacaatcct atattcttat cactttactg 2417521 agcaataaat accttccgta tacttagtaa taccttcatc gtaatcagga tacttatatg 2417581 caagaccttc tgatacagct tttgaatact ttctaaataa tgcatagcaa gtaaataaag 2417641 acttccacat ttcctgatac ccattcacag aatatgtaga catgagttcc tcccattctt 2417701 tatttgaaag gtaccgcttc ataaatttat agttcttccc catactaaat gaataccctt 2417761 tctgagatgc gatatgccag gccatcattc tcaataaatt aggacgtaca atttcattta 2417821 aatggtcaat ggcaaaaagg atttcatttc ttgctagtcc ttttactacg taagtcgaaa 2417881 ccatccagaa ctcattacag caatcatcaa attcccttgc agtcggcctt tttatccagt 2417941 attggcgatc atttggggtc actttatagt tgatgaacga atccttatca agcaatacct 2418001 taaccaaacc atcgttatta gcaaaataat cttctgcttc acgaattgga ataagggtta 2418061 gatctaattt gttgccatcc tcaaaaagaa taatgtatga aaaccaatta cctaattcgg 2418121 gaggaaaaag ctccatatct tctggttttt gcatcataat gcgcttccca aagatttcga 2418181 gccactgatc attttcttta aaagattcta catcagttac aaaatacgag atgtcataat 2418241 cttggaagtt gtcaggaggg atatttctgt ttgtacgtga cccttccaaa gtgaccaatc 2418301 ggattctctc atcgttcaaa gcaaagtcca aaaaaatgtc catcatttcc tgctcacttc 2418361 gcattacatg ttcctccgtt tcagccttaa tatctaactg taaaacgtct tatagatttt 2418421 tttactcttg aatgtgatgt attcttctaa gctttatttt acatgatgtt ctcctatata 2418481 tcattcaata ttaagatgca agacatctca aaatcagata tcaactatga cggactacat 2418541 gaatattcag ttttttgtag agccgccatg ggacgacact atctttgaca cactttaatc 2418601 ccccctgctt tatcgacatg ttaactggta tgagagattg acaaaaagaa ggaaaacgat 2418661 atatttaagc gaatacgagt ttttgagtaa attttaaaat gacacttttt tcaaaaatca 2418721 tgtcttaacg ggaggattcg gtatgaatga atttatgaaa aagttttctt taacaaaacc 2418781 gattattcaa gctccaatgg ctggcggtat tacaaagccc cgacttgcat ctgcagtttc 2418841 gaatcaaggt gctcttggca gcttagcatc ggggtatctt acgccagacc tcctagaaca 2418901 acaaataaaa gaaatatttg agctgacaga cgctcctttt caaattaatg tgtttgttcc 2418961 gctaggtcta gagatgccac caaaagatca gattaaaaag tggaaagaaa acataccgtt 2419021 agctaatcaa gtaaatcaat tcacatctgt acaagaagag tgggatgact tctatcaaaa 2419081 aattgatcta attttaaaat acaaggttaa ggcttgctca ttcacttttg atctgccgcc 2419141 tgaagacgca gtaaaggagc taaaaaccgc tggatgctgt ttaataggaa ccgcttcaac 2419201 agtagaagaa gcattgttaa tggaagaacg gggaatggat atagtagtcc ttcaaggaag 2419261 tgaagccggt ggacatcgcg gagcattctt accttccaaa ggtgaatctg ccgtaggttt 2419321 aatggctctg attccacaag cagcagatgc actgagcgta cctgtcatag ctgctggggg 2419381 aatgatagac cacagaggag taaaagcagc tttaaccctc ggagcccaag gcgttcaaat 2419441 cggttctgcc tttttaattt gtcacgagag taacgcacat ccagtgcata aacagaaaat 2419501 actagaagca aacgaagcag atacaaagct tacgacatta ttttcaggta aagaggccag 2419561 aggaatcgta aataaatgga tggaagaaaa tgaacagttt gagacacaaa cccttccgta 2419621 cccttatcaa aatacactaa cgaaggcaat gagacagaag gcttcacttc aaaataacca 2419681 tgatcagatg tctttatggg caggtcaagg gatacggtca ttgactgagg aaatttcggt 2419741 taagcagctt ttaaatcagc tttgccaaga ggatataaaa atataggcgc acctcattga 2419801 tagagcaaaa agcaaacttt gacaggcagt ttgctttttt tttcgtaatt tcatccactg 2419861 actctggaaa tctaaatact cctacatttt caaagctaat ttgaatcggg ttatcaatca 2419921 tcacattgat acgatgcgat cttgataatt tcaccacaac cacaatacat taccaacatt 2419981 tcgatcttat ctccccttct caagttttgc tccctattcg aataatcgat agctcccata 2420041 ttaaatttga atagtaaaat ggttcttttt cgtttgattc agatgatata aagtcatatg 2420101 ataaaaaaag aatgagacag aaagcgtgag aagtgatgaa aataggattt tttgattcag 2420161 gaattggtgg catgactgta ttgtatgagg ccataaaagt tcttccttat gaagattaca 2420221 ttttttatgc agatacgtta aacgttccat acggtgaaaa atcaaagggt aaagttaaag 2420281 aatatatttt caatgcagct gaatttctgg ccagtcaaaa tatcaaagct cttgttattg 2420341 cgtgtaatac agctactagc attgcgatag aggatcttcg gagaaacttc gactttccga 2420401 taatcggaat cgaacccgct gtaaagcctg ctataaataa atgtacagag gaaagaaaaa 2420461 gagttctggt agttgctact aatttgacgc ttaaagaaga gaaatttcat aatctagtta 2420521 aagaaattga tcaccatgac cttgttgatt gcttagctct tccaggacta gttgaatttg 2420581 ctgagaactt tgattttagt gaagacaaaa tcattaaata tctaaagaac gaactatctt 2420641 cttttgatct gaaacaatat ggaacgattg tgttaggatg cactcatttt ccgtttttca 2420701 aaaacagttt tgaaaaactg tttgggataa aagttgatat gatttcaggc agtgtcggta 2420761 ctgcaaaaca gttgaaaaaa gttcttgcag atcgtaacca gcttggtaaa ggatcgggct 2420821 caatcacctt tttcaattct ggccataaaa ttgtggacca agaagtcata tcaaagtaca 2420881 aaagattgtt tgaaatatta gatgaaactc aaaggagtca tgttggacat tgaatgtaaa 2420941 tgaaaaagac aatctcctga agagaaacat gaactaagaa gcgggcttaa aaagcccact 2421001 ttttttctaa caaacaattg agttatacac acatatctga ttacagtgtt ttctctcttt 2421061 cccctcttat ttctcccccc tctctatagc ttttctattt caataaaaca caagtctcga 2421121 ttgaaaagtt atcgtaacat ttacacttca caggagattt ttcacgattg cgaatcgacc 2421181 gtttgccaga tgcacaaagt cataatgtgt aaattctgta tctatgtgca tgtttattat 2421241 ggaattattt tcataatgtt ttataataca agatgatagc gttttctaat tataatgata 2421301 gggggaaata atgatgatga aaaaaggtct gcttgcgggt gcgcttacgg caaccgtgct 2421361 ttttggcaca tgtgcagtag atgtaccggg tattattagt ccaaaaaccg cagaagctgc 2421421 atcacagcta actgatggaa tcggcgggag ggcttacttg aacagtaatg gtgccattct 2421481 tgttacgaaa atccagcttc ctagctccac tcaggtttca aatgggacag cctacatcta 2421541 ctctggtttt agcggaggca cagaatccga tatcgggttt cagtacagtg ataaatataa 2421601 tgtatggaaa ccatatatga aagtcggttc aaaaggacag gatcaggttc agtacctcga 2421661 aggaggaagc caattcacga atacgaaagg cttccgtccc ggcagcaccg tacaacttac 2421721 catctacaaa aaccttaacg gcaatacccg cgctacatac tggggcacga acaatgccgg 2421781 atacaacggc cgtctcattt cagaaatcag caaaacaaat gtcggctcca tctcaaaatg 2421841 gaaagcgctc gctacagttg caacaacagg gtcacgccaa tctatcaaat caaacttttc 2421901 aacatctttt acaaacatca ccatcgacaa caaagcaata acacctgtaa ttgatacaca 2421961 agacttcgct aaagtaacag tctcaggcaa cagtgtcagt ttatccgttg tcaaaaatta 2422021 aaacatgtta aacatacaat gcgttaggct attgagaagc tctcgatagt cttaaagggg 2422081 gcttaacatg cccctttttt catttcaatt taactttcag ttagcttcgg tacatgccgt 2422141 ctatccccgt cttttatctg ggtgaagtaa gggcagctcg ccccttctga acctgttcca 2422201 tttgctcaac gcaaaaggtg tgcatcactg tcttaaaaat gttaaaacaa atagcagatg 2422261 gtgcacttta tttttagatg aggcatgctt acgctcgata tgcaagtcaa atgattaagg 2422321 gtctgcaaga gagagaagtt ttgggtgtac tttcataaaa gagggatggc ttcatatagc 2422381 tcgattgcat caggaagatt agccaacgat tggccgagaa caacacatca ctttgaaacg 2422441 gattcattcc aaaatcataa gtatgatcca ataactaata aagatcagtt agcagtccag 2422501 ccttaaaaat atttttacat caattaaact agcatcacta tcgaataagc tcgatctgca 2422561 tatcatgtac tatcctcttt taaggaaggt gatgttatga ggtcatttcc attaatcgta 2422621 gttctattca tcctattaat catcgttggg acatctttct ttggtggcta ttaagaacac 2422681 accttacctc atatccatca gacgccataa gaaatcttta tggcgtctgt tttttattag 2422741 atttaaacaa aaccattaaa gtgggccatg caaacacacc tatggagatt actgccacga 2422801 cttctttgtg agggaattat tcttcccttt atggactatt gtcgatcaaa agagaaagtt 2422861 gaaatgcatt tttatggtga gatgaatcga ggcttagaca tataaaaaac cgcaaagctt 2422921 tcttgaagaa gctttgcggt ttttgggtct cttctttgct tcatataagc caatagattt 2422981 caagcgtaat ccactgccat acatccaatg attttttatt ttgaaatagg tttcttctac 2423041 tcttcatgtg agatgactca aggtatgcca cgtcacaata atatggcgga tactgaatgg 2423101 tctcaatcag ttttttcccc attctatcaa ttctccacag aaaaaatggc tatggcagaa 2423161 caactttcat agagtaatca tcatttaatg agccatcatc tcatgggcaa tatcgtgtcc 2423221 atccattttt gacgggtagt aagtaggcca gtttttgact tcatcaagta aagcttcacg 2423281 gtcgtccccc caatagagat ggtaatgact agctttagtc gggtaaatac tatgatcact 2423341 aaactgaata tactgaggca gcccttctgc ttttttagct agtttgaata tgtatcttac 2423401 ccctctattg cccgcatcat aggttagaat ttcgtatccg tcatacgtat acttaccaga 2423461 atattctttt ccatttttga agaacgttac agtatctttc tggattacaa tacggtcaac 2423521 atctgtttga tagccttttt tataatactc tttatattct tcagctgtct tgccgccttc 2423581 gtgttctgat ttatatgaaa acacttcgtc aagagtacca tcttgcaggt atggatatac 2423641 agattgccaa tctccttccc aatcagaaag taagcgatcc tttacttggc tgtttttaaa 2423701 atagccttca tatatttttt ctgtttcttc atcatgcgca tgactatgat cgtgagaatg 2423761 ttcgtgtgta tgactgtcag atgtttgctc ttgcgttttg gaagagtctt cttcaactgc 2423821 tgaggatgat gttgtttgat tagactcacc tgcagaagaa ccggaagtct gacatcctgc 2423881 caaaactagt aatgaaccaa tcgttaatat gcctagccgt tttgaaaata aaatgttcat 2423941 tccaacactc cttttttatt aaatcgaaaa cattacgatt tattatacat acatctcttg 2424001 caaacatcaa aggaaaaatg ctcttcatgc ggatggccta ttttaaagga ataactgact 2424061 atgttcatca gttattcctt taaaatacga aagtctacga tatttccata tcgatccgct 2424121 tcaatgtgac agcacccctc aagcagctgt tttaattttc cacgtccgcg ttgtaccctt 2424181 gattttgctc cggagtaaga aatgccgagc ttttcactca actctttttg tgataacccc 2424241 tggaaatcag ttaactcgag cgcctctcga tacttttcag gcaaccgttt gatggtcgat 2424301 cgaatacaca cagttgcttc cttggtgaaa ttttcttcct ctgcactgtc attaaaatgt 2424361 agaacatcag gcaatatttc gcttgttttt tttgtacggt aaaaatcaat aatcgtattt 2424421 ctagtgatcc gataaatcca gctgtcgatc ttttgttcat cgatcagatt tgggagatgc 2424481 acttgtattt tcataaatac gatttgcaag aggtcatcaa cgatagattg atcgttaacc 2424541 ctatgtgaaa tatatgtttt taacggctga tgaaattgat cccatagatc ctctatattc 2424601 atttgaaaaa acctcctata attttgcgtc tgctttacat ttgcttcgtc tttttaatcg 2424661 taacaaagag caaacaattg ttgaatcaat tgtattgcag ctgttgccaa aaataatgat 2424721 aaaggagagg tttgttgtgg agtataccta tttagggaga acaggattgc gggtgagccg 2424781 tttatgttta ggcacgatga attttggagt tgatacagac gaaaagactg cgttccgtat 2424841 catggatgaa gcacttgata acggcattca attttttgat actgccaata tttacggctg 2424901 gggcaaaaac gcaggattga cagagagcat cattggaaaa tggtttgcac aaggaggaca 2424961 gcgccgcgag aaagttgttc tggcgacaaa agtatatgaa ccgatttctg atccgaatga 2425021 cggaccaaat gatatgaggg gcttgtctct atacaaaatc agacgtcatc tggaaggatc 2425081 actgaagcgg cttcagacag atcatatcga attgtaccaa atgcatcata tcgataggcg 2425141 gacaccgtgg gatgagatat gggaagcttt tgagactcag gttcgctccg gcaaagtaga 2425201 ctatattgga tccagtaatt ttgcaggctg gcatttagtt aaagcgcaag ctgaagctga 2425261 aaaacggcga ttcatgggac tcgtcactga acagcataag tatagtttat tagaacgaac 2425321 agctgaaatg gaagtgctgc cggctgcacg ggatcttggt ttaggagtag tggcgtggag 2425381 tccccttgca ggagggcttc ttggcgggaa ggcattgaaa agcaatgccg gaactcgtac 2425441 agcaaaaaga gcagatttaa ttgaaaaaca tcgtttgcaa ctcgagaaat tttcagattt 2425501 atgcaaagaa ctaggagaaa aagaagcaaa tgtggctttg gcatgggtgc tggcaaatcc 2425561 agttttaact gcgccgatca tcggaccacg aacggttgag cagctgcgtg atacgataaa 2425621 agccgttgaa atcagtctgg ataaggagat tctccgcatg ttaaatgata tctttcccgg 2425681 acctggagga gagacacctg aggcatacgc ctggtgatac attcattact caatactgac 2425741 atttttctta aatatttata ctgaactatc atattaagaa agacaagagc atgtttgtct 2425801 cttgtctttt ccacatcgtg ctgaaaatgc tggctaaaca tcgacaaaaa tgctgccgct 2425861 taaaaaagaa ccctaaacaa tagagtaact ggaaagacaa ctggcttgat cagcttggga 2425921 cccctttcag ctgtatttaa atcaatcaaa ctaatgattc attggcagtc taaatattat 2425981 tattgtttct ttacaaaata gtaatagccc ctgtaatgat tgctaacaac gtaataacta 2426041 atgatgtaat tacagcccac ttaacggcaa acctttgaaa tgaccccaag tccattttaa 2426101 gcatgcttac tagcaatact gttgacgcaa ccaatggact catcagatga accggctgcc 2426161 ccattataga agcccttgca atttctactg gttctatacc atatgctgag gcagcttctg 2426221 caaagatagg taccatacca aagtaatatg catcatttga taaaacaaaa gtaaacggaa 2426281 tactagtgag tgctacaata acggggaaaa accctcccat tgatgagggg atgatggata 2426341 ttaatgatcc tgctatggca tccaccatct ttgtcccgga taatatacca gcaaatactc 2426401 ctgctgaaaa taccaataat accacggtta tggcattacc agaatgctcg gcgattcgct 2426461 ccttctgcat ttttacattc ggataattta tagtaagggc aagaacaaaa ccaattaaaa 2426521 ataaaactga cggatgctta gttccaagca caataaacac catgatactt ataacgagga 2426581 ataaattaag atatattaag cgtggccttt tcaattgttc gctctccaaa gtagcagcca 2426641 tataagattg agagctgtcc tttgttatat gtctaggctc taattgaacg atgcctattc 2426701 gattcctctc tttccttccc attagaaaag ccagaaatat cacacaagca atacctccaa 2426761 gcatggtcgg aagtaatggc acaaagaaat ctgaaggatc caaacccagc actgaaatcg 2426821 ctcttgtagc tggtccgccc catggagtca ttccgctaac gatactcaac gacagcattg 2426881 ctaatgtcgc cataaccatg ggattcatac caattctttt atacaaaggt aacattgctg 2426941 agactgttat catataggtt gttgtaccgt ccccatctaa agcgataagc attgccaaga 2427001 cggcagaccc tatcgctatt ttcacagggt ctccctttac tatagataaa attttttcta 2427061 ttagcggatc aaataaacct gcatcaatta aaattccgaa aaaaagaata gcaaacaata 2427121 gcaatgccgc tgaacttgca actgtttgaa ttccttctaa aatcatgtcg ccaataccct 2427181 taccaaaacc tccaataaga gcaaaaacaa tgggagtgat ggtcaaggca acaataggcg 2427241 agactttctt tgtcattatt aatattgtaa aaacagttac catcgaaaaa cctaaaatag 2427301 taagcatatt acacctccaa gaatgcgctt tcaaatgact tttgattaac atatcttata 2427361 cggtgtaata agttaaataa atattttttt actgtgtttc aaaaaaaatt ctatcataac 2427421 tttaaatggt taccatttgt tcacccttta aaaaatcaat gaatgcttta acgagtttga 2427481 ttcctaatga tttttgatcg tacattagcc aagtatctct cattagaggc ttacccttag 2427541 cattatacag ttccattgtg tacaaatgat cagattcctg caggcaaatt tctggtgcta 2427601 tggagtaacc aagaccatgc tttaccatct ctttgcaagt ctcttgtcga tccacttcca 2427661 ttgcaataat gggggcttgt tttagattcg tatgcatcca atcttctata atcgttttta 2427721 aagaagcatc cgttttatat ttgataaaag gtaaaaaagg aagttgctct atcgttattg 2427781 gtttttttga gatgatatgt aatttttccc gtgtcagccg ttcctccacc cctttccagc 2427841 gatggcttcc tctcagtata ccgacttgta caataccagc atctaataat ttcatgacat 2427901 ctgtgctcca gcctgtttgt acactatatt ggacattagg atacatagtg gaaaattccc 2427961 ttaataactt agggagctta tattgagcga aattgcttga tacccccagc cttagatgtc 2428021 cttgcacctc tttgcttaga ttagagatat gatctttggt atcttgaagt tcctgtagca 2428081 ttcttcttgc ataagcaacc aagtgttctc cttccgcagt aaaggtaatt cctttatgcc 2428141 ttttggtgaa taattcaatt ccgaaaatct cctcaatctt tttcaaccga taagtgatgg 2428201 aaggctgtga tgtaaataat cgttctgctg tttttgttac actttgttct tcgtgaagaa 2428261 ttttcaataa aatccaatct ttctcatcca ttttcatctt cctttctagt ccttctttca 2428321 caattataaa agttttttta tcgaatatta agaaaactta tattttattt ttattttttt 2428381 accttctaca ctaaaaaaca taaaaaatac tacctttaag atgaggatga tgacgatggt 2428441 caagacgaat gtaacaatca tgagaggcgg aacaagcaaa ggcgtttttt tccacgaatc 2428501 agccatgcct aacaataaaa acgaatggga gccctttttg cttgatgtca tgggaagtcc 2428561 tgataaaaga caaatagatg gtttgggtgg cggtaattcc cttactagta aagtggcaat 2428621 aataaagaaa gcatatactt cggatattga tgttcactat actttcggtc aagtcagcat 2428681 ttcggaagaa aaggtggact ttaaggggaa ctgcggaaat atctccgctg ctgttggtcc 2428741 atttgctatt gaagaaggac ttgtaaaagc gaaagaacca atgactgcgg taaggatcct 2428801 gaataccaat acgaataaaa tgatcattgc ggaagtagaa gtggaagacg gtcaggtcaa 2428861 atatgacgga gatgttacga tatctggagt acctggatct ggatctccaa tctatttaaa 2428921 ctttcatgat gccgctggtt cagttaccgg tcatttattg cctactggaa atagttcgga 2428981 gtttttagat acaagtcaag gccaaataga ggtgtctatt atcgactatg caaatccatt 2429041 agtttttgtg gaagcgagca gtatcggcct ggatggaacg gaacttgcag aagaatttac 2429101 tgatctacag ttggctcaat ttgaagaatt aagatccatt gcggcagaga aatgcggctt 2429161 tgccagtcga ttttcagcta caaagttatc gccggctgtc cccaaactgg ctatagtagc 2429221 aaaaccagag aaatataaag atagtacagg tgcttggcat tcaagcgttg agatggactt 2429281 acacatcagg atgatgtcca tgcaaaagcc acatcaagca ctggctgtca ctggagcgat 2429341 atgtacaaca agagcccttt cagtggaagg tgcaatccct gcaagaatag caaaaaacca 2429401 ctctacaaag gttcggctag ctcattcttc tggtattatt gaaacaatgg tggagcccac 2429461 tggtataaag atcgtccgta ccgcacgacg tattatggac ggaacagttt atacgcatgg 2429521 agactatcaa atgatgtaga tggactgtgc aaaaagcctc ccccctttcc atcgttaata 2429581 gatggattga atgcgccttc ttgcacagat ccattgtaat cttgcatggc tttaaaaaag 2429641 cctctatatt gttttttatg aaatcgccaa ggtcctttca tgtatctgcc tcaagcatga 2429701 cataatcatt atagagaaaa ttgaatactt tttactgcaa ataaaaagat accaacatca 2429761 ttggtatctt ttagattgag ttcatctgca gcggtttctt ttcctcactg cttatttgat 2429821 tacaaaatta ccgtactcgt ttgaacgaac atgaatcggt ccgtttagat tatagttgtt 2429881 ctccttggcg atagagcgaa gcacgtccac acgggcaact gattctctcc attcgtcacg 2429941 ggtgtcatga ttggccggat tcatcagatc gtcatagcgt acgtccaaga atttattcaa 2430001 ccacttcttc tcgtctattc cgtctttagg tgatccgccc gcttttttgt tcgtacgttt 2430061 aatcaaggca taaaaagagt cagggtcatc accatcgcca tgctgaataa ccgtatcgta 2430121 catcacagct cttgccaatg ctgtttttag tccggcatta tccgatcgtt tcatggcagg 2430181 ctgataatac aaatggtcat ttactttgtc ttgagcggcg cgaaattcct tatcatttgc 2430241 aagcgacttc caggcagaag cgaatccctt gagattgctt gtatcatcgc tttcttcctt 2430301 ggccagacgg cgcaattcag gcagatactt tttcagtttg ttattcggaa ctgcctttgt 2430361 gtatacttcc actacttcca atgcatcccc ggtagccgtt gtaaagcctg cccgtccgca 2430421 tgtatagcct cgcccgtcat ccaatcgctc tacatatcca tattggatct ccgttgtgcc 2430481 gttttcaaag atacttgtca gctgttccgc ccggcgcttt tgatctttat tcagtcccgc 2430541 cgcaaaaacc gtttcgctca tcatcagggt aaaaaacatg gtgaaaacaa gtaatgagat 2430601 cgctgctttt ttccaaaaat ctgctttttg catactgatt ttcatttcac ttcccctttc 2430661 taaatattgt aaatacagac tcagtataca tgaagaaact gccctattgt tgaaaataca 2430721 tcaatttgtc aatattttga atctaaagta atatagcttg aatcttactc tattcattgc 2430781 caatcagcct tagcccctct cactgggaag gtcccttgat tttcatactg cttcaacttt 2430841 cattaacaag atgccataag gctttactct attttataat ggaagtgatc atcgaaaatc 2430901 gttagggagg tgatgtaatg gcaagcaaga tgagaatgcc agattccgca acgtcccatg 2430961 caaagcctac tattgggaag gcgatacttt gcatggggta gactttctaa aagatcgccc 2431021 aagtaagctt ttctgatata gtggctttgc accttatttg acataaaaaa ataaggagct 2431081 ggcagaaatg gcatatgtaa aagcaaccgc tattttacct gaaaagctga tatcggaaat 2431141 tcaaaagtat gttcaaggaa aaacaatata tatccctaaa cctgaatcct ctcatcaaaa 2431201 atggggtgcg tgttcaggaa caagaaagct gatcgatgac agaaacgctt ctattaaaaa 2431261 agcatttaaa aacggcaaaa ccattcatca attatctgat gaatatcacc tctctattga 2431321 aacaataaaa aaaattgtct actctaaata aacaaaacgg aagcactgat aaaaaataat 2431381 cagtgctttt tatatggcga gtttgtttct tagttatttc ctgcatatga taccattggc 2431441 caattgtgta aagttaaggg agatgagaag aaaggaaggt cctacaaatg acgataaaca 2431501 atggaacgtt gcaagtaccc ggcgcgaaca tccactatca ggtgcgtggc tctggtccaa 2431561 tcattctttt ggtccacgga ggaggcggtg atgccgacaa gttccatcat gttgccaatc 2431621 atctggctaa ctggtacacg gttgttactt atgatcgccg cggccattcc cgcagcaatc 2431681 tcgccaatca gattgagggt taccgtgtgg aaacacacag tgacgatgct caccgtcttc 2431741 tagccaaaat caccaataag ccggcctatg tatttggaag cagctccggg gctgttatcg 2431801 ggcttgatct gtgcatacgc catcccgaac aagtacatgt catgatccca cacgaaccaa 2431861 tcttattgca gcttctgcat ggaaatgagc tgaaacaagc cgagcaattc atggaagacc 2431921 ttaagaaaaa tcatcgaagt gaagtcatta aattaatgtc aagattagag acagacgaac 2431981 aatcaaaggc tgtcctgaca aagcggcttc tcggcaattc aacgtatttc actgagtatg 2432041 aaattcaagg aattctcagc tatacattag atttcgaagc attaaaaact gtgtttacat 2432101 cttcaccgat gaagatactc ccagctggcg gaagtgcttc tcgggagctt tttccttatc 2432161 gttgcgcgaa cgccctagcg gaacaattgg aaacagaatg ggttgaattc cccggaaatc 2432221 atacggggta cacaatgtac cataaagaat tttctgagag gttacacgac atgttagaaa 2432281 aagaaaagaa acatacgtgt taaggattga ttaaaatttt caaaatagga caggtgaaac 2432341 taactatgga attggagaag atttcacgaa gcgtaaaaag aacttttcac taacgagaac 2432401 gcaatgtgag atgtttaacc aaagtgatat tagggatttc atcgaaaaat aggtttgtac 2432461 attacgttct cctattgatt atttcctatc ttaattccgt attttatacc attagataca 2432521 actctaaagc ggctcgttat tttgtcctca acaacaacca gtgtctaaca tcatgaatct 2432581 cttttgaaaa tcaccacaaa tgcaggtatg gaagacttca tcgcagcaaa aaccatacca 2432641 actattgttg ttggtatggt tcgtcctaga taggccctta agaagagatt ctattgtacg 2432701 gagtatttag ctaattgcat ttgtaaccga cagggccgtc tgaacctgtg tacacatatg 2432761 tgtcagacac atatccaata ttcacgacac cccgggaatc tttccactgg atttggtccc 2432821 agatattact cgttccatac ttccctgtaa cagtcgttcc ataagcgtaa caataataag 2432881 gaacacggga gccactcgga atggaaagca taataggata atttgtacca ggaccgctgc 2432941 gcatattgac aggcgcaccg ctgcttgttg agacagtaaa gtactgaacg gcaagtgcct 2433001 gactggaaaa aatgaataaa gatgcaatca tcacggttaa catactcagc attttcagtt 2433061 tagtcaatgt catccctctt tcttcaattc cttcatttta agaaacgata gaacataggc 2433121 taccagctgc atttaggaac aaccggaccg tctgagcctg tatacatata tgtatcagag 2433181 acaaatccag gaacgatctc cccgctggca agcgtccgct ctgtgtaatt ccaaatattg 2433241 ctcgttccat actttccagt tacagttgta ccggttttgt agcaatagat cgggatgcgg 2433301 gttccgctcg gaatggtcgt tacaattccc caacttgtac ctgggccgct gcgcatgttg 2433361 acaggagcac cgctgcttgt tgaaaccgta taatactgag ccgcaagtgc atggctagaa 2433421 aaaatgaaca cagatgcaat catcaccgtt agcatactta gcctctttaa cttattcacc 2433481 ttataccctc cccttataaa tgccgtacgt ttgactttct tacatccagt taaggattta 2433541 ctttcagata ccatgccccc tcccctccca tatatttatc aatgtaccat aaactagatc 2433601 tttcaaaagt ggaattattc ctatgttttc gacaattaag gatacaaaat aaatggtagt 2433661 caggcttgat attgatggtg tgttacattt ggctcttaat catttgtcca gtcggtaatc 2433721 acgattgaca atcaggaaaa aggacatgga tcaagcggct tcgtttccac caattaactc 2433781 aatcagtgta ctgcttcctt gtatccacgc ttcttctcga ttcatagata ctccaccttt 2433841 ttcaccaatc aaaaacggac accatacaaa tcagcgtaaa tgctgcaagt tcagtgtccg 2433901 caacctatta tgactttgct ttcttttacc agggcgtgta aaaatgatta ggtacgttat 2433961 caaacgttat tctatgattt tgcgagtcaa aaaatcataa cattttatat atttcaatca 2434021 gattatgatc tggatctctg aagtgagcaa ctcgggcact ccattccttg cgatcatgcg 2434081 gtttattctc acatttaact cctttttcgt gtaaatcgtc atacgtttta tcaacatctt 2434141 ctaccttaaa ctgaagcaaa aattttgatt gagcttctcc ttccaaggac tttttttcct 2434201 ctccaacgat ttcagccatc gtttctcgag ataaaagctc tattttcgtt tccccattat 2434261 caaagagtgc atattccatt tcattctcta accaacttat tggaagtcct aatgaatctt 2434321 tataaaactc gacgcttttc ttaaaatcat tcaccaacag tctaatttgt aacagcttca 2434381 tatcgagtgc ctcctataaa accatacttt tactggtcat ccaatttaat gataccaaag 2434441 aaacctgaca gcactatgtc aagtttccat acttcaccct tatttcagat ttaagtgcag 2434501 tttagtccat gtcataagaa cgagcaaaaa cagcgattct taaaacaaaa aatgataccg 2434561 agtgtatttt ctgtatgctt caacttcatt tcgggaaatg taacgttgat aaaaggaggt 2434621 tacatcaata tggatcatca aacattggca gctcatgagg ctgttgactt acatgaaatc 2434681 gtgaacttta aaacactttg tatagcgaaa tcaaagttaa tgcaagggct tgtgtttgac 2434741 caagaactga aggacttgat ggaaaaagat gtacagcaat ccattcaaga ccttactgaa 2434801 ttacaagcgg tttatgagcg tgcctcattt caggcccctg tccctcaaag ccgcccaacg 2434861 ccaatcatca attgaaaggg aggtaagcct ctttgaataa tgatcattta gaccccatta 2434921 attcgctgaa tgtgcctgaa ctagcagaca ctacattcgc gatggatttt cttatacgag 2434981 ctaaggaagg cgtaaggaat actgctgtag ctttgacaga aaccgcttca ccagatgtaa 2435041 gagcactgct tcggaaacag ctgatgcaag gaattgcgat gcaccaagag attacggaac 2435101 tgatgatcag caaaaagtgg ttccatccat atgagctgag cgaacagtat aagctggatc 2435161 agctctctgc aaaaaacacg atcatggtcg gcaatatgaa cctctttcct gatgaaacaa 2435221 atcgcaaagg gatgtttgac cggacacctg atgaacacta acactggagg ttttacagca 2435281 tgaaggcagt aacgtatcaa ggcattaaaa atgttgttgt caaagatgtc cccgatccaa 2435341 agattgaaaa atccgatgac atgattatca aagtcaccag tacagccatt tgcggatcag 2435401 atttacattt aatccatgga ttcattccga atatgcaaga agactatgtc atcggccatg 2435461 aaccgatggg aatcgtcgaa gaagttggtt ctggggtgac taaactaaaa aagggagatc 2435521 gggtaattat tccctttaat atagcatgcg gggaatgctt tttttgtaaa aaccagctgg 2435581 aaagccaatg tgatcagtct aatgacaatg gggaaatggg tgcttatttc ggctattcag 2435641 ggcaaactgg cggttatcca ggcgggcaag ctgaatattt aagagtgccg tttgcgaatt 2435701 ttacccattt taaaatccct gaatcttgtg aggaacccga tgagaaatta agcgtgattg 2435761 ccgatgccat gaccaccggc ttttggagtg tggataatgc cggcgtaaaa aaaggcgata 2435821 cagttatcgt tctcggctgc ggaccagtcg gcctgtttgc tcaaaagttt tgttggctaa 2435881 aaggcgcaaa acgcgtcata gcagttgact atgtaaacta tcgcttacag catgcgaaac 2435941 gtacaaacaa agtagaaatc gttaattttg aagaccatga gaatacaggg aattatttaa 2436001 aggaaatcac gaaaggcgga gcggatgtag tcattgacgc tgttgggatg gatggtaaaa 2436061 tgagcgatct cgagttcctt gccagcggct taaagcttca tggcggaacg atgagtgcat 2436121 tggtcattgc ttcccaagct gttcgcaaag gaggaaccat acaaattaca ggtgtgtatg 2436181 gaggcagata taacggtttt ccgttaggag atattatgca gcgaaacgtc aatatacgct 2436241 ctggacaggc tccagtgatc cactatatgc cgtacatgtt tgaactagta tcgacaggca 2436301 aaattgatcc gggagatgtt gtcagccatg tcctgccgct tagtgaagcc aagcatggct 2436361 atgacatttt tgattcaaaa atggatgatt gtatcaaagt tgtgttaaag ccttaaaaaa 2436421 cggaggttac agaaatggaa tacgccttac acgaagtgct tgaggttcag gaaatgactg 2436481 catttaagac actttgtttg acgaaatcta aaacaatgaa agcactggta tctgatccga 2436541 agctgaaaga aatcatgcag caagatgttg atatcaccac acgccagttg caggaatttg 2436601 cctctatttt atctaatgca aagcaagaat gaggagatga ataaatcatg aatcctatca 2436661 tagaatatct gactggcatg aatgttctaa cagaccaaat cattgctatg gacttattaa 2436721 tttcagcaaa gaacggagtc agaaattatg cgatggcagc cactgaagcc ggaacgcctg 2436781 aagtaaaaga ggtccttatc cgccatttgg aagaagcact cgatatgcac gaacaactct 2436841 caagctatat gatggaaaaa ggctggtacc atccttggaa ccctgacgaa caagtcaagc 2436901 tgaatttaaa aaatattgat acagccattc aattgccaac cctttaacat acaatgactg 2436961 atttgctgag gaacagtatt gattggccac aactgttcct cagcttcaaa atgagcactg 2437021 tttgttcggg tcctatgacc gtaaatagat taaccgcttt tctccatctg atctccgata 2437081 atgtttgcaa attctccaat ccaaataagg aatcgtaacc acctcttttt atgcgatctc 2437141 ttgatggaga aaacaggcca gaaacaaaat ccttcgtttt tgacctgccc tcttcacacg 2437201 caaagaatgc taccttcttt gctccactga tccgtgaaga ctttccgttt taggcctgct 2437261 tttgagcttt gcctcatttt cacgcaattt cccatcataa tctttaattt ttgtgtctaa 2437321 tctcttaatt gtttcatcaa tttctttccg cttctctatc agccgctgtc gttcgtcagc 2437381 caggatattt tttcgagctt ctaccgtacg gtcaccttcg gtaaataatg ttgtatattc 2437441 aattagcgct tctatcgata gtcccgcatt tcgcatgcat ttaatgaatt caatccattt 2437501 gatatcttct tcatcatagt cgcgaatgcc gctgtctttt cgttttacag gcgggattaa 2437561 tcctacacgt tcgtaatatc ggagtgttgc ggctgtcagg ccaaactgct ttgccacctg 2437621 agcaatattc atgatcttca cctctctatc ctgtatgttg tgaaggtaac acttaaagtt 2437681 aactttaagt caagctcaaa acaagtggtt agctgctgaa tctgggttta tatattcggg 2437741 acttgcctta aagcacactt taaactctat acttctccat gcactaaaaa cagtgtagtt 2437801 ggagggattg ctgaatggca aataaacaca ctgccggaag agaacaatta ggagaatttg 2437861 cgccaaagtt tgctgaactt catgatgatg ttctattcgg tgacatttgg gcaagagaag 2437921 aagaactttc atcccgggat cgcagcatga ttacagtttc tgcattaatt actgactgtt 2437981 tctcagctta taaatcaggt tcattttaaa tggttttttt aaaaaaccct tgccttaaag 2438041 cagactttaa ggtttatcgt tatgttgaag acaccataaa acataaataa gtgcatgttt 2438101 ttatttacaa cacttatgat gaagaaagga taggttcgta tgtgtaatca acatcaaacc 2438161 cgtgtattaa gcgtgtcaca tgcaaaagcc aaatttgaac aaacgacgat tgagcgaaga 2438221 ggattacggc cgcacgatgt cttaatcgat attaaattca gcggcatttg ccattcagac 2438281 attcatagcg cttttgatga atggggcggt ggcatcttcc caatggtgcc tggacatgaa 2438341 atagccggtg ttgtaacagc cgttggaaca aaagtcacca agttggctgt cggggaccgc 2438401 gttggtgtcg gctgttttgt tgactcttgc ggagaatgcg aatactgtct caacgcagag 2438461 gaacaattct gcacgaaggg tgttgttcaa acgtataact cagtagacta cgacggaaac 2438521 cccacttatg gcgggtacag ccaaaaaatc gttgtcactg acagatttgt tgttcgcata 2438581 ccagatcgtt tggaaatgga tgttgccagt ccgctgttgt gtgcaggtat cacaacgtat 2438641 tccccgctga aacactggaa tgttggccct ggtaaaaagg ttgcgattgt aggcgtaggt 2438701 ggccttggac atttggcaat tcaatttgca catgcgatgg gtgcagaagt aaccgtcctg 2438761 agccgttcca tgaataagaa agaggaagct ctggaactcg gtgcaaatca ttactttgca 2438821 acaagtgacc cagccacatt cactgcattg gccgggcgtt ttgacgtgat cttaaatacg 2438881 gtatcggcaa atctcgatgt agatgcctat ttatcaatgc ttcgtataga cgggacactt 2438941 gtaagcgttg gagctcctgc caagccggac acatacagtg tgttttccct aatcatgggg 2439001 cgccgcagca ttgcaggttc tctagtcggc ggaattcaag aaactcaaga gatgctggat 2439061 ttcgcagctg agcatggcat cgaacctaaa atcgaagtca tcggagctga ccaagtggac 2439121 gaggcatacg aacgtatcct ccgaagcgat gtccgttatc gatttgtgat tgatatttcc 2439181 acattgtaat aggttagtcc ttatatgggc tgccgctttt attgaaactc acgaaaaatg 2439241 atctctttaa gcaaatattt tgaaggccgg tcaatcttcc tgttattcta tgaatagaga 2439301 gttattagga gggtttttta tgagcaaaaa aattgcagtt cttgttacag accaattcga 2439361 agacatcgaa tatacaagtc cggtaaaagc atacgaagaa gctggctaca gtgttgtggc 2439421 tatcgatttg gaagccggca aagaagttac cggtaagcat ggcgagaaag taaagattga 2439481 caaagccatc tctgatgtgg atgcaagtga ctttgatgca cttttaattc ctgggggatt 2439541 ctctccggat ttgcttcgtg cagatgaccg tccgggtgaa ttcgcaaaag catttgtcga 2439601 aaacaaaaaa cctgttttcg caatttgcca cggcccgcaa gtactgattg atacggatct 2439661 tctaaaaggc aaagatatca caggctaccg cagcatccgc aaagatttaa tcaatgccgg 2439721 tgcaaactac aaagatgcag aagtagtcgt cagccacaac attgtcacaa gcagaacacc 2439781 tgatgatttg gaagcattta accgcgaatc tttaaacttg ttaaaataac aagaaggcac 2439841 agactgttcg ggtctgtgcc ttttttaaaa ttaagactcc ttcgttacat tctgaaagac 2439901 agcagtcgcg tcccacacat tcaagccaaa ttggccttct gaaaatacgg aatcatgtgc 2439961 atcaatcaca agacgatcat ctaaatagat tttaaagcga tcgccctcgg cctctgtttt 2440021 cagatgatac tttttattaa cgtctatcgg tgttttgtat tcagcaatga cagaagcagc 2440081 accgttctca aatttaaaga atttcactag gtcatgcttc gcatccacat tggcaaggta 2440141 accgtttttg gcatctttgt cagagcgaaa cattagtgct cctgcccctc ttccgtttcc 2440201 atccttaatg gtgatatcag attcataagt gaagtctgac ccggatgctg aagacaagat 2440261 aaaggaatcg ccgtccgacc tcccttgttt cccctcaatt gtgtctgccc acgtgccatt 2440321 tacagtcgtc cagccagtca tattggacat aaaaggtgtc gttccccata ccttttttaa 2440381 agggtgtatc gttaaagatt ttacctttac accgccattt gcagcatata attcaagccc 2440441 tttgcttgat cggtctggga gaataatatc cgttatgacc tgctttccgt cattcccaaa 2440501 tacttcaacc gaggagcggt caacaaaaat gcgcaactta accttcccat ttaccggctt 2440561 caacggggct gtttcttttc cggtgttaaa ggccggatta aaggtgtcgt tgcctgactc 2440621 gctccggtca acgaacaatt tggcgttcct tcggtcatag ccgaccttcg taaattgatt 2440681 ttcacctgtt cggaccttaa aaccaaattc agcagctgaa ccagggctta ctttaaattc 2440741 tgcatttatt tcataggcat ctccagattg ccccgctaac acattatgac ttgcaggcga 2440801 tatggtcaga ttcttccact tcttagaggt tccgcgaatg gtttccagct ctttcaccgg 2440861 tgtttggacc actctaaccc cttcggtaaa cgctttcaat tttaactctc ttggaatgga 2440921 cgttgcactt ctccatgggg atgtcggaac atcattcgca tattgccaat tgctcatcca 2440981 ccctaaccat agccggcggc tgtctgtgga tggaatatca gaccaggata cagccgcata 2441041 aaagtctctg ccgtaatccg tccagagaac tttgtttggc gggttttcat ttttaaaatg 2441101 agttccatca aagtccccta caaaatattg catgcctgat cctcccgaga ccgctccgtt 2441161 tccgacactg acctgcatga cccatttctt ttgattcgga ttgccgtcta ccggaagctc 2441221 aaataaatcc gggcattccc atactccccc gtggcttcct tgatcctgtc caaattcact 2441281 tgcatacgtc cactgcttca gattttttga tgtataaatg aggattcggt caccggccgc 2441341 aagcaccatc acccactttt tttctttctc ataccaaaag acttttggat cgcgaaaatc 2441401 ttttttaccc gggtttggaa tgacagggtt gccagcgtac ttcgtccatg ttcttccttt 2441461 gtcgttgcta taggcaatac tttgcacttg atggccttcc cgatcctgtg tataaatggc 2441521 cacaagcggc ttctctttgc ctgtttgaaa accgcttgtg ttatttttat ctacaactgc 2441581 gcttccagaa aagatcgtgc ctttttcatc cggatacagc gcaacaggaa ggtgttccca 2441641 tgtaaccaaa tctttgctga cggcatgccc ccaatgcatg ggcccccact gaagcccgta 2441701 tggatggtat tgatagaaca agtgatattc cccagcataa tataccattc cgtttgggtc 2441761 attcatccag tttgcctccg gtgtgaagtg atattgagga cggtaatcct catcatagta 2441821 gcttgaatcg gctgcatctg ccgaaaatgc catagtcaac agcagggtga acatgatcat 2441881 gacttgaatc agtctctttt tcatttgttc cttcgctcct ctcttcatgt ttgaacactt 2441941 tcaaaagaga ctgctgcgca agctggtccg tttctggcaa ttctcctctg tttcactgtt 2442001 atccgaatga tttatatatg aaaagactgc tgcagtttct ctctctttcc ttcacacacc 2442061 ttatgctaag aatccagccc aatacccgag aatcccgatg acaaagatgc cgcaaataat 2442121 gagaagtgga ttcacccctt tgcgaagcat ccatgccacc aataacgtta atccgagagg 2442181 cagcgccccc ggcataatgc tatctagcac gttttgtacc gtttgaacat ctacttttcc 2442241 gctttcatcc ttaatcctgg atacaacgat tggaatgttg atggtggtcc atttggacac 2442301 gagagccccc ataacaaata acccgagaat cgaagcgccc tctgtaagct tttgaatgcg 2442361 attccccgct aaatcctgaa gaatctccat tcctttcaca tagccatact ttaatccgta 2442421 atattttgtg cttaatctta tggcattcag caagaaaaag aatagcaaag gaccggcaat 2442481 gtttcctcct aaagcaaggg aggctcctag cgcagctaag acaggacgaa tcgttcccca 2442541 aaaaattgga tcgcctacgc ccgctattgg tcccatcaaa ccgattttca ttccgcttat 2442601 cgcttttccg tcaattcctt tattgttcgc catttcttct tccatggctg ccgtcacgcc 2442661 aaatataggc gctgtcagcc acggatgtgt attaaaccat tccaaatgcc gctgtaaggc 2442721 ttcgtttctt ttcgctccgg gaccgtacaa ttttttgatc gccggtatca tgacataaca 2442781 atatcccatt gcctgcacac gttcgaagtt aaaggaaccg agtaaaaaat ttgaacgaat 2442841 aaacatgctg aaaatttctt tcttcgttaa tcgtttttct ttctccattt tttcttcccc 2442901 ctcatcgttt aggcatcaag atcatcatca tcgtcatcat aaacagcaac actgccactg 2442961 tctgatgcgg ccgcgactgc tccgtgagcg ctttgttttt gcatcacctg ctggtataaa 2443021 agcgccagac agagaccaag ggctccaaat cccactaagt taaaatcggt aaacgccgct 2443081 aataagaaac caatatagaa aaatggcttt aaataaggaa tattcatcat attgatcacc 2443141 atggcatacc cgacaaccac aataatgcct ccgcctattt gcagtccttt tgtaatgaca 2443201 tcaggaatat ttcccaggaa cgcctgaaca gcgctgacac taattaaagc aacaatcaat 2443261 gtaggaatca tgacgcgcaa agcttgaaac accatcgcgg taatatgcat aatttcaatt 2443321 ccttttatat ttcccgcttt tgcatattga tcagcgcggt ggatgaaaaa gacagtgatc 2443381 gtccgaacaa aaatcgtcag cgcctgaccc gcagctgcta aagcaacagc gacagcaatc 2443441 ccttcgccaa ttccttgatc agcggtaata actaaaatgg ttgagatgac agaggcgatc 2443501 gctgtatcag gtgccatggc aagcccgacg ttcatccagc cgagcgccat cagctccagt 2443561 gtgcctccaa gaataattcc cgtttttaag tccccgagca ccaagccaac caacgtacag 2443621 gccactagcg gccggtgtgt ctgcccttca tccaatacac ttgcgattcc ggtgattgct 2443681 gcaatgatta acaacaaaat aatttgtaat gaagacatat tctcatcccc ttgattattt 2443741 tgttacgttc cgtaaaatct gtacaaaatc ctcactggca tctgaaggca gctgcctcaa 2443801 ttccagtttc acgcccttgt cacttaatgt ttcaaatgcc tttatatctt gttctgtgac 2443861 actgactgat tttgtgattt gcctgcgatg attttcaaaa cgcattcccc cgacgtttac 2443921 ggttttgatc ggtacacctg cttctataag agatacaata tcggacggat tttcaaacaa 2443981 gagcattgcc gttacccctt cgtagcgcgg actatgaaat gcttttgcca ttttagaaac 2444041 cgagacggca ctcgccttta catttgaagg cgcaacagaa aggatcagcg tttttctcat 2444101 ttcgtcctga gcaatatcgt cggagacaac gatgattcgg tcggctgcat ggacttttat 2444161 ccaccttgtc aggatttggc cgtgaataaa gcggtcatca attcttgcta acacaatgtt 2444221 catcataatt catcctctct tgtatcttga ttggctgttt ttactttttc taaatgttca 2444281 ctgcacactt gaaagctttg ctgactcatt gcttttaagt tgttcagcaa atctttgaga 2444341 gccagatgtt ctctcaggct taatacctcc agcagaatcg gcaggtttac gccggcagcc 2444401 atatccattc tttgatcctc agcaataaag gaagctgccg cgttatatgg cgtccctcca 2444461 aaaatatcga ctaaaaaaag cacttcatgt tcttccggga tatccttgag cgcctgatga 2444521 tatttttctt gcagcgtttg tattccttcc cctttgaaaa acggcactgc aatcaggtta 2444581 ttttcttcac cgaatatcat ccctgaagac tcttttaatg ctatgggaaa atctccatga 2444641 ccgctgataa taactgaaat catatctatt gctcctttcc tgttttgtac atccatatat 2444701 aatgcaagga tcgtgccaac acagttgtgt taagcgtttt cattgttatt tcagccaata 2444761 gcaatttgtt gttgaaacac ttaaaacgaa aaaaataaac ctgtattaaa atggtgttcc 2444821 atttaataca ggttcatatg aaaaaactgt ttttaaaaca gctggccatg cacttcttca 2444881 gcaaatatgg cggctataaa taatttttca tcatcactta tgcgaagtcc gagcttttct 2444941 tcataagggg ctaatgttcg ctctgtcacg tacaccattt ccttcagctg atcattgatc 2445001 tcttcttcct ctgagaaagc gatcggattc tgcttaatta ccctttcaaa ggcgaaagcc 2445061 gtgtgcataa tgactttgat caaaaccgca ttattgaaaa tgacccccag ctcatcctga 2445121 acggtttgca gccactccaa taacatgtcg atcacatggt ggggattcaa gaagacaagg 2445181 tattttttca ggctatcctc gcaaagctcc ctgacaataa tatttgcttc gttcaatcca 2445241 ttgctcaagg agatgcttcc ttttgtaatc gcctgttgaa tcagcttctc tccctcccct 2445301 tcaattaaca cttctaaaga tacatgcgga gcattgattt tagggtcttt cgttccgact 2445361 gtcgcaagga tttcatactc tttttcgatt tcttttatgc tgttggccag cttaatcgat 2445421 gatacggtca atatgtgaat gggggtatcg gaggccttgt ttacgatcgt ggttagaatg 2445481 tcttccagct ttttggccgt tccgctaccc gtcgtgcaga tggataccaa tgccttcttt 2445541 ttgccggatg ccgctggctg acgctcccac aactcgataa aatccttcgt gaccgattga 2445601 tagatcgcat gcaaatttaa attcaaatag ttgacctttc tgacagcatc cagcaccatt 2445661 gaagtcgtaa cattgctgat cgttttaata gaaatgcctg tcttttcctc cagcctgctt 2445721 tccagcattg caagcgaccc catatctacc agcattaaaa caccttcacc ttcatcaacc 2445781 tgtttcattt tttctgctac gcattcaaga atgtccgaag gtgaaacagt aagcggcatg 2445841 tcaactgctg caatcggcgt actccctagc agttctgtcg cgacttcaac cattgaactc 2445901 gccgtgctgt ttccatgagc tgccacgata ataccgactc ttttgttctc ctttaacgat 2445961 ttgatggaat gaattaacat cgttaagtag atgacttcta tttcaggaat agccacttta 2446021 aaatattcct gaattttatc tttaaaaatc atcgccaccc gatattcttt cacatgggta 2446081 tcacgaattt catctgtctc ctgtgtattc aaaacatcaa tttgctttcc tcgctttaaa 2446141 aatgcgtcaa tatgcatact caagaaataa ataaacttac ggtcaaatgt gcaatccagc 2446201 tcatgttcag ctatttcttt taactgtttt gtcatttgaa tcacatcgtc ttcaacgaat 2446261 gtcagcaggt tgtctttttg aaaagcttga tgatgaaaaa aacttctgac atgcaaatgg 2446321 acatcagtca agatgtactg gttaatatcc tttttggata aaccttcttt cataagcgtt 2446381 ttcacttttt cctcaatcaa atgatataag ttaaatgaga ggtcttcgtc aatttttgtt 2446441 gtttcatctt ctacaatcgg agagataatc gttgtaatat tgacatattc agaaatggct 2446501 ttgcttcttt gcatgttttt gctgctggac atccattctt gcttgatttc atcaggcaga 2446561 tcgcgaacag tcagttcaat aacttcattt ctgtcaaggt tatgcaaaaa tccgtgtgcg 2446621 caaactaact gaacatttga tttcagctgt ccgacattcc caaatttcgc agagtgaata 2446681 agcgcattat agacatcgat atgcacactc agattcttct taattcgctc tgcttctttc 2446741 cctaataaaa acgtcgtcag atccactctt tcattaagcg atcgttcttc aagcgaagga 2446801 atatgaatgg tcattgggat tcttcgcaaa aacgttttca atagtgcaga actcggattt 2446861 tctgtagtcg cacaaataaa caatacgttc gatgttcgtt tatgttcaga ttctccaagc 2446921 ctgttataag aaccgctgtc aataaaataa aacagcattt cttgtccctc gggagggaga 2446981 cggtggattt catccataaa aagaatgccc ccattggcct gttcgactaa acccgcctta 2447041 tcctcggcag cacctgtaaa tgaacctttt ttgtgtccga ataattgaga aagcaataat 2447101 tgagggttgt tgtagtagtc tgcacagtta aatgtaataa atggtgcgcc ggccttcaat 2447161 atgtcagagt aaatggcaaa ctggtaaatt cggttcgcaa aaagggattt accggaacca 2447221 gtcggcccta ggaggagcat atgcagaccg ttcggcggat aaaagacagc tgcttttgcc 2447281 tgggagatcg ctttcttcaa actccctttt gcccctatca taagctctag gggattcgtg 2447341 gaaatgtgtt gatgattttg ctttgaattt ccggaaaacg cctgaaggtc tttcacttcc 2447401 atcatctctg tatcccattt cttgttgaat aatttttctg ctatctcgac tgggatgtat 2447461 cttacaggaa atgttttaat tttgatgacc tttttggacc ggacgagatt gttcaattca 2447521 aagctgacat tggaccgctc cattttcagc tgctcggcaa tctcctttgc tgaattccct 2447581 tgtattttta aaagatgatc taaggttgaa tcatgaaaat tatgcttgag ctgatggtat 2447641 attttatcta ttcttctcac gtctatcatc ctttgtcctt attagataag ccattaacaa 2447701 gaatatttcg aaactttata gtccgcgttg agatttacac gtttaaaaag gtctctatag 2447761 cagattgaca aagctggctt ttatgcgtat atgtttacat gttgaatcat ttgcacctca 2447821 tattagtatg atagatgctc agttctggag ggccagtccc cttcaaaagt aataatcagt 2447881 aaacagttta tcattctcgg ggaatgtaat gatgtcaaaa taatcaatga caaaaaatga 2447941 atcttataga tcatgacaaa ttacccaaat ataacccctt aagttcgttc acaactaaaa 2448001 agacggacac tctatgtgac cgccacagta ttacaatttg caaaacttcg tcatttttgc 2448061 aatccacatt ggaggttaag gaatctgtaa gcttaaaaac tttatctccg atcctatcga 2448121 tttgatcccc ctgccggcct caatcatagt gggtatgcaa ttatacaaat cgttaccgat 2448181 taaaactagc ctgtcagatt gtccaaatga ctttcctgtt ttactctgct attcaggtag 2448241 aatcacgagt gaaaaataga gccacaagac atgtaacagc acttaaaata gttttaaaat 2448301 ttaaaaataa aagtatctat tcttttaaat gttataatat ccgataaaac tttactcatc 2448361 tttttattac tggaggaaaa taaaattgat aggcaattct agcaaagaca attttggcca 2448421 gcaacagaaa ttgtctagag gccttaaaaa caggcatata caattaatgg cgattggagg 2448481 tgcaatcggt acaggtttat ttttaggttc aggtaaatcc atccattttg caggaccatc 2448541 cattttattt gcttacttga tcaccggcgt attttgcttt ttcattatgc gttcgctcgg 2448601 agaactgctc ttatcaaatg cgggatacca ctcttttgtt gattttgtaa gggactattt 2448661 aggaaacatg gcagcattta tcactgggtg gacctactgg ttctgttgga tttccctcgc 2448721 gatggctgat ttaacggcgg tcggcattta tacgcaatat tggcttcccg atgtgcctca 2448781 atggctgccg ggtcttcttg cgcttattat cctgctgatc atgaaccttg ccaccgttaa 2448841 acttttcgga gaattagaat tttggtttgc attgatcaaa gtcattgcca tactggctct 2448901 gatcgtaact ggtattctcc tgattgcgaa aggtttttcc gcagcttccg gccctgccag 2448961 cctcaacaac ctttggagcc acggcggcat gttcccaaat ggatggcatg ggtttatcct 2449021 atctttccaa atggtcgtct tcgctttcgt gggtattgaa cttgttggac tgacagcagg 2449081 tgaaacagaa aatccccaaa aagtgatccc taaagccatc aatcaaattc ctgtccggat 2449141 tttacttttt tatgttggcg cacttttcgt gattatgtgt atctatcctt ggaatgtgtt 2449201 gaatccaaac gaaagcccat ttgttcaggt cttctctgca gtaggcatcg ttgtggctgc 2449261 cagtttgatc aattttgttg tattaacatc agccgcatca gctgcaaata gcgctttatt 2449321 cagcacaagc cgaatggtct attcacttgc aaaggatcat cacgcacctg gactattaaa 2449381 gaaattaact tcttctaacg tgccaagcaa tgcgctgttc ttttcatcca tcgccattct 2449441 gattggcgtt agtctgaatt atttaatgcc cgagcaagtc ttcacgctga ttacaagtgt 2449501 ttcaacaata tgcttcattt ttatttgggg catcacggtg atttgccatt tgaaatatcg 2449561 aaaaacaagg cagcatgaag cgaaagcaaa caaatttaaa atgccttttt acccattatc 2449621 caactattta acacttgcat ttctcgcgtt cattcttgtc atattggcac tggcgaatga 2449681 tacacgtatt gctttgtttg tcaccccggt ctggtttgtt ttattgatta ttttgtataa 2449741 ggtgcaaacc cgcagaggac ataaggtgaa ataaaaaaaa gacaagggat actcactccc 2449801 ttgtcttttt atatgtgtca aacactaaat taaactttgg tttcaaattt cattcacttc 2449861 atttaagtgt taactcaaac cagttttgat gccgaaacct actaatatta ttccggtaat 2449921 tttttgaaac actttctgga acttcgagtt tttcatccat ttttttgcgt aatcaataat 2449981 ataaacaaga aacaggaacc acaacaccgc taataaggtt aggattgaag ctaaaatgat 2450041 gagctgctgg tttatatttc cgttcaaatt gataaattgg ggcatgattg taacatacac 2450101 caaaacagtt ttaggattga gaatgttact gagtgatccc tgcataaagg aagttttata 2450161 ataacgtttc ggagaacttg ccatattttt tgcttgggat tgcatgtcat ctaacgaaaa 2450221 catactttta gcaaaaaaac tttttacacc taaataaatt aagtatgccg ctcccaaata 2450281 tttgatcgtt gtgaaaagaa tcactgactt tgcgattacc actgataatc ctaaaatggc 2450341 aatcaccgtc caaaaggaaa gtcctgtcgc caatccgaga atgttataac ggccggcttt 2450401 cggaccatac ctaagcgtat ttttcatcac aagcatcgta tctgcccccg gtatgataac 2450461 catcatggca gcgatcggta tgtatgcgag taagctgtgc attgttctct ccccctttaa 2450521 aaatcccctc aatcatatag tgactacaaa agtaactact tataaaagtg tatcaatgcg 2450581 tttggaataa atcaatatga tttgttaaaa tagcgattac taaggcagcg attgctcttt 2450641 atattggagg atatatgaaa gaaaatatgt tagacatttt aaaaaacctc aattttacag 2450701 aatatgaatc gaaagcgtat ttagcattat tgcaagaatc acctttaaca ggctatgccg 2450761 ttgccaaaaa atccggagtg ccccgttcta aaatttatga agtattggaa agtcttgtca 2450821 taaggggaga tgtttttgtc agtcatggaa atacgcctca gtatgttcca gtccccgcaa 2450881 aagaactgat taaaaaccgc cggctcaaag cggaagagca ttttgatcag gctgagaaat 2450941 attttgaaaa gttcgagcag accgcaaatg accgggaaaa catctggaat atcaccggcc 2451001 gcagtgaaat tcttgaaaag gtgaaggctt gtatcttatc tgccaaaaaa agaatcctct 2451061 tagaaatatg gaaagaggat tttaaggaga tagaagcaga gctcaaacag gcggcagaac 2451121 aaggcgttat tgtcaccatt attgcgtacg gagacatcgt atctgatttt gccaatgttt 2451181 accttcatga tatgagcagt gaaattacag aagagtatga cggacggtgg cttgtctata 2451241 gcggagatga ttcagaagta gtagcgggca ttgtctcact tggcaacgac agccgtgctg 2451301 catggacgat gcatgtaggg ttagtcatgc ctattactga agtgatcatt catgatctgt 2451361 acctcatgga aattctgaaa aagcatagag agcttttaga agagagcttc gggaaaaatc 2451421 tcatccagtt gcgccgtaaa ttttctattc actcagattt caaaaaacat tatttggaat 2451481 aatgtttgtc atctcttacc ccaaaaacaa ggcttgtaca aaacaagcct tgttttttta 2451541 tgcataaacc ccccatgctg atttacttct ctcttttaaa aaatgtgatt ctgcgcaaac 2451601 tatttttcag cctgccgcgt ctatcctagg taacagccta cgatatacgt atattcaaaa 2451661 aggagccctt tattgcaatg aagaaaaaac aaacaacaaa agcgttgctt gtcacatgca 2451721 taactgacca taagcaagat ttctacaggt tggctttcag ttatgtgaaa aatcaagatg 2451781 acgcattaga tattgttcag gaatctataa aaaaagcgct gagctcagtt gaaacggtca 2451841 ggaaccctga gacgataaaa agctggtttt ataaaatttt agtacggaca gccattgact 2451901 ttttgcgcaa acaaaaaaag ataagagtga tggacgacga aacgatagaa tttttaagca 2451961 aaggaaagga agaccattac aaggatactg atctccatga agcgcttgac gaattgccgt 2452021 accgctataa aaccattatt attttacgtt tttttgaaga cctcaaatta gaagaaattg 2452081 cggaaattac aggagaaaac acgaataccg tcaaaacgcg cctatacaga gcattgaagc 2452141 tgatgcgcat tcagttgacg aaggaggatc tttcttaatg gataagagat tacagcaatt 2452201 aagagaagaa tataaaaatg ttcagattcc taaagaattg gatatcattg ttgaaaaagc 2452261 ccttcagcaa gaaccaaaaa agaaaagaat cgttatgtgg ccgacatcag cagcaatcgc 2452321 tgcagctatt ttattcactg cgcttgttaa tatcaacccg gacgccgctc aggctatgtc 2452381 aaagatccct gtcatcggca aaatcgtcaa agcgatcacc tttattgaaa tcaaagagga 2452441 aaaagaccaa tcaagcattg atgtcaaaac acctgctttg tccgggcttt ctaataaaga 2452501 gcttgaaaac agcattaacg agaaatactt gaaagaaagc cagcagctgt ataaagagtt 2452561 tatacagtcc acatccaaaa acaaaaaagg gcatctcagc atctacagtg attacgagac 2452621 ggtcacagac acgccagatt tactctctat ccggcgcaat attgaaacaa cacaagcatc 2452681 ttcctacaca caaagccgtt atattacaat tgacaaaaag aatgatattt tacttacatt 2452741 aaaaagctta ttcaaagatg agcgctatat caaagtcatc agtcaaaaca tcaaagaaca 2452801 aatgaaacag caaatgaagg aagatccaaa taaaatatat tggctcactg acgaagatgc 2452861 agaaccgttc aaaacgattc ttcctgatca gacgttttac attactgaag accataaact 2452921 tgtgatctca tttgacgaat atgaagtcgc ccccggctat atgggcgtta cagagtttac 2452981 aattccaacc ggcgtcattt caaacttgct cgtgggagaa cgttatattc gataaaataa 2453041 aaacatccat ctaagattat ggatgttttc tctcttctct attcgaggtc gtaaccccgc 2453101 tatcaaaaac aacgagaata tttgcatact attggaggaa tacccatgta tcacaagaca 2453161 cagcatcatc gatacattcc tggacttgat ggccttcggg ctttcgccgt cctgtcagtt 2453221 atcacttatc acctaaattt caattgggct aacggtggtt ttatcggggt tgatatcttt 2453281 tttgttttat ccggatattt gattacatct attctattac cggcatatgg aaatgatatc 2453341 aatcttgatt ttcgggattt ttgggtgcgc cgcattcggc ggcttctccc ggcagcgtac 2453401 cttatgatct tttccactgt tgtgtgggtc gtattgtttg atcgagaact attgcacact 2453461 gtacgtggag atgcgatctc ttctctcttt tatatgagca attggtggtt tatttttcac 2453521 aagctatcat attttgatag tttcggttcc ccatcacctc taaaaaacct ttggtcgctg 2453581 gcgattgaag aacaatttta tatcatatgg ccgatgtttt tagttgttgg aatgtacata 2453641 atgaaaagcc gcgccagatt ggctgcggtg atatcattgc ttgtgctttg ttcagccgtg 2453701 atgatgagcg tactgtatga acctggcgga gatccgagcc gcgtttacta tggcacagac 2453761 actcgttcgt ttgaacttct catcggatgt gccttggctt tggtatggcc gatgaaaagg 2453821 ctgtcttcca acaggctgcc aagcaaactg aagcacactt tgcacgccac tgaatttttg 2453881 gcattttgta ttttagtgtt gtgtgtctat ttcacagatg aatacgagcc ttttctttac 2453941 agaggcggaa tgctattcat tagcgtgact gccgcaatcc ttattgcatg tgtttgccat 2454001 ccgagcagct ttttaggcaa tctgctttca tggaggccgc ttcggtggct tggaacgagg 2454061 tcttacggaa tttatctttg gcactaccct gttattgtgt taagcacgcc agttcaagaa 2454121 atcggaaacc ctgttttttg gcatatcgtg ctaaaggtca ttgtgacatg tatacttgcc 2454181 gagctctcct accattttat tgagaagccg atacggacac agggatttag gtcattttcc 2454241 cgccgtgttt ttatacatag aatcaaggaa tggaaaacga catctgtcat cagcaaaatg 2454301 tcaattggtt tcattatttt cgctatactt atttttgcag gcgggctgtc agggctagcc 2454361 ggcgagcaaa agcaccctac caaatggacc tatagctcac aagaaacaaa tgctgacacc 2454421 agccaggctt ctggggataa aaagaacgct gcagcagata aaaaacacaa tcctgaacaa 2454481 aagacaacag attccaatca gggtcaaaag gaaaacaaag atagtgggca agagactcat 2454541 aaaaagaaag acacgcaatc ccaacagttg aaaaaaccag cagacactgc gaaagaagtt 2454601 ttagctatag gagattccgt catgcttgat atttcttcac acctgcgtca gtcattttca 2454661 aatgtgacga ttgatggaaa ggtagggaga caaatgtctc aagctttgga actcgcaagg 2454721 gaatacaagt cttttaatca gccgaacaag gctgtcatca ttgagcttgg aaccaatggc 2454781 tattttacaa acagccaaat cgaacaactg cttcaatctt tctcaaaagc tcatatttat 2454841 cttgtcaata cacgggttcc ccgccaatgg gaaagcaagg taaatgaatc tttgcagcaa 2454901 caggcccacg cacatcaaaa tgttacgtta gttgactggc atacagaagc tcttcagcat 2454961 ccggaatatt ttacccctga tggtgttcac ttggttccta aaggggcaaa aactttgact 2455021 gctcttattg ttcaggcgat gaaatcgtaa aaaagagatc ctatacagat cactttttta 2455081 ctttagtttc tgatcgttga ttatgtcttc tttcagcaag gcagccctta tgtttacatg 2455141 ccgtttacgt aagggtaagc caaaattgaa tggagggatg ataatgaaag gaaatgaaga 2455201 acatgacatc caaaaagagt tgaaacgata tgagcttttt ttcaaaaaac gatataaggt 2455261 tctttataca gtaaacgatt ttatcatcgg tgctatgttt ctcgttggaa gttttttctt 2455321 tttttatgac cggttaatgt cggcagggat atggctgttt gcgatcggaa gtttgctgct 2455381 gttaatcagg ccgaccattc ggctgattca tgactttcat taccgtaagc atgtggaaca 2455441 gcaattcaag catcaatctt caacagatga ctgatcttaa ggaataagaa agaacaaaat 2455501 gccaaaagcc tgagtcgaaa atcaaaaaca agactttcag actatttatt tttaaaaaca 2455561 aggtaaaaag aactaaactt ttgcctctgc atgccgatat gaataataag gccggcgcga 2455621 tactccctat aacatccttt tcagtagatt tcattatcgt gccggttttc tcatatgcaa 2455681 agcaatcccg ccaatcagat tggcgggatt ttatatttta cattcctgtc caaacgtctt 2455741 tcacataacg tctttgatct tgcagctttt gcagccatac agctgattct tcctgacttg 2455801 ctgctttttc agcttcatat gccaatcgca aagttctctc tacatcagga gccatttgcg 2455861 atccatcacc gcatacgtaa atatgagccc ctttttcaat gagtgtcatc aatttctgcg 2455921 tatcttgctt gagcaagtgc tggacatatc cttttggttc gttttcgacg cgcgagtagc 2455981 atcggcggat tgtgaccaaa ccgtcctgtt ccgcttgatc cagctcttct ctgtaaaggt 2456041 cgtcatggtc cgggcggcgg cagccgaagt ataaaagtgc ttcaccaagg gtgcttcctt 2456101 ccttcttcaa aaccgatctt gcctgaataa agcctctgaa tggcgcaatt cctgtgcccg 2456161 gcccgaccat aatcataggc gtttcaggat cattcggcat ctgaaatccg gactgcggcg 2456221 tacgaatgaa gcaagctgct gcatcacctg tattcaattc tgctaaataa ttagaggcga 2456281 caccccggta ttcacctcgg ccgctccatg ctgaggcttt cacaactcct accgtcatgc 2456341 tcacgatatt tgcatgaact ttcggtgagc ttgaaatgga atagtatctc ggttttagtg 2456401 atggcaaaag tgctaaaaac cgttcaaacg gcatttcgca agcaggataa tcctctaaaa 2456461 aatcaagcat ggtaagacgt tttgcaagta cctgctcttt gtaaatgcca tcatctgaaa 2456521 cgagctgttc cagctctttt tgatgcggcg gacaaactgt ataagaggcc agctcccgaa 2456581 gctgaagcct tgatgccggt tcctgcagct ctacatagga cgacaataaa tccactactt 2456641 tgattggccg atccatcggc agatgagcca tatgagcgct tccgcttact tttatcacat 2456701 gattggactg caaaccgaat cggctgagaa cccgctgaac aagctccctg ctgttctttg 2456761 gcaggattcc gatatgatcg ccttctttat atgttttacc agccggaatt tccaattcaa 2456821 tatggcgggt tgaacgcgtg ctggcagctg tctggagttc tcgattctct aacacaatcc 2456881 cttcaaacgc gccatatgct ttagcaaccg gcgtttccgt cgcttcactg agaaaagtaa 2456941 tcgataatga aggcctgtct tctttctggg ctatttcgtt aatatcaaat gcgtccatcg 2457001 tttccttcca gaagcggttt tcccaagact cgcggtggct ttcaaaatca tcggcggcgt 2457061 caccttcccc aatcgctgtt aaacgcgatg ccccctttgc tttcatcatg tcatcaatca 2457121 ggcggggaat ccgctgatac gtgctggccc agctccggtt tccgcagccg aataccgcat 2457181 aggaaacacc tttcaattgg ccttcctcaa gctctttcag ccactctaca aatccggcag 2457241 cattatcagg cggcgcccca ttataagaag ccgttacaat gacgactgcc ccttcttcag 2457301 ggagcttgcc gatataatca tcaagcggag ccgtttcagc tgtaaagccc atctggcggc 2457361 cttgagcagc cagttcaccg gctattccct cagctgtccc aagatttgaa ccaaaaagaa 2457421 caagtaaagg tgtgccgtgt ttaggtttgg tttcttttgg ctttgtttct gctttgatgt 2457481 ctgcctgttc ttttctctgt acattgattg ccgctgtttt tcgcggtttc acagtaattt 2457541 taaaatcatc cggcttgatc gttaatgctt ctttgatttt tagttcgtag ccagtatggt 2457601 ttatcaattc aaaatgcttt aatacaagac cgagaaccat tgtcgcttct tgaagagcaa 2457661 actgcatgcc aatacaagcg cgctgtccgt ttccaaacgg cttatacgca tggtgaggga 2457721 tacttgaagg atcctcaaac cgttccggac ggaaatcttc cgcatccggt ccccaagcgt 2457781 tttgatcccg gtgcagtttt ggaattaaaa cagtgactgg ctgccctttg ctgatcggat 2457841 attccccgcc tagaacagta tcctccttcg catatagaga aaaagccgga gctgttggat 2457901 acagtctgag ggtttcattt aaaaccatcc gaatgtattt gagctgctgg atttgtttat 2457961 attcaggcgt gtcatccgtt aacacgcgat ccgcttcctc ctgagctttt ttcagttttt 2458021 ccggatgtgt aagcagacaa taaatcgcaa aggatagcaa cccgcttgtt gtctcatgtc 2458081 cagcaattaa aaatgtgatg atttggtatc gaatgttttc gtcatccagc gtttcacccg 2458141 ttactggatc tttggcataa agcatgagag acaagagatc cttaatgttt tcatccggat 2458201 tcgcctttcg ctccgctatc attctatcaa ccagggagtt catgacttct atatcctttt 2458261 ggaactgcag cttcgttttc accatcattt tatcttgcag gcccagtctt ttcgattgat 2458321 tcatcgcctc ttttaaggca cggagcatac tggtgataaa cggatgctgt gaatcacggt 2458381 aaaagctgtt gaatcgatag ttaaacccgc ataacccaat cgtatcaagc gtcagacgtg 2458441 tcatatcgtc cgctacatca atttcttcat tagggtttaa ccggctccac ttttgaatca 2458501 gctgggttgc gatatccagc atcatagaat gatagccttt catcgctttt tgactaaaac 2458561 tcggcagcaa aatgcggtgg gctttttgcc agttcggttc gtgcgtccag cttgtaaata 2458621 agccatctcc cccgaactca cgcacctttt gcaagccttt gccaaggttc ttgtcaaagc 2458681 gtttttcatc acacacttca gccacaagat tgtggccgga cacaaaaaca ctggatactc 2458741 ccggaaaatc aaaacggaaa atcggtccca attcatcagc tatccgccat aaggattgag 2458801 aaagctgttc tttttccaga tgcggaagat tttttaaagg tccgtatgtt ttgggctgag 2458861 gtattgcgct tgcctgtttc attaacatct ccctttccta tttttgtgat gaatgaagct 2458921 taatggcgtc ccagcagcat tgttccaatt cagtaattaa atcagtgtcc atctctatat 2458981 cacctgtttg aacgagctga tatatcttga gaaacgcccc taatacaatc gcaattaaca 2459041 cattagaggg caggctgcga atcacgcctt ccgcttttcc cttattaaaa tagtcatcaa 2459101 gcatttgagt cagattttct atcatttttt tgcttgtatg atttaagtaa tgagcgtctt 2459161 ttttggtttc aagaaaaaaa agcgcatagt cgctctcttt cgtaaactga acgagacagc 2459221 aaaatacgtg gtgaaagcct tctctgacag gcaattctga aacgtcttgc ttcagttttt 2459281 ccgtaaatcg ctggatgctt tcttgaaaca gtacgttaac gagtgtttct ttgctgtcaa 2459341 aataacgata gatcgttcct gtccctacat gagcacgttc agctatcata ggaatagtgg 2459401 tagcgtcaaa acccctttcc gtaaaaagtg agactgacgc tttcataatc atgtcgtatt 2459461 tactgctgga tgcggatatc atgtaatctg acaacctccg attcgtttac ggaatgaata 2459521 ttcattcctt ttgttcacaa agaatgtctg ccctgtctga tatcacctct ttgttctttc 2459581 ttctgttata agtttatatg aaaaaaactt tttttaatat aaagtatatg caaaaaataa 2459641 aaaattaaga aaatataccc aaatcctaat acgaggatct tggatatatt tcccgagaaa 2459701 ttttttattt aacagccaca atacatagac aggaagcacg cctgataaca gaaagatccc 2459761 tgaaatgctg gtctttcagc agttgaatat acgttttctc tttttcaccg gtatttgtgt 2459821 caatactgat ataaaaccgg ccgtcaattt gaagcaccct gtaaatttct cttaatgcaa 2459881 gcctaatatc ggtgcagctt tgaaccgtat gtaaagaaaa gactttatta aaggtacggt 2459941 catcaaaggg aatgtcctct ggatagccat gaaaaacctc cccgttcccc atgttctttc 2460001 gattcgcacg tgatatctgt cttacctttc gttttgaagg atcaatgctt tttaggctac 2460061 ccttttttag tttcttggtt atgcttttaa agacagtgcc gtttccaatt ccaatttcta 2460121 aaattctgtc attttcttgt atatctatag agtcaatcat catatgctca attgttttgg 2460181 ttagcttata tttccgagaa aataatttcc aaaaatccga tcgtttatag agtctatttt 2460241 ctagcatttt aaacacctgc ttttggtttc ctatgtttat ttattatctt aaaaaaataa 2460301 acatcatctt catttctaaa agtgaaggaa ggtaccaact agacggcaat gtattgaaaa 2460361 atgtttcaat agaactaaac tttttcattt ttttccgaaa aaaaagcaga aaacataatg 2460421 ttttctgccc tctttctaat gccaatgata agggaataca tacagccttt gctgctgcat 2460481 tgccatcagc ctctgctgtc ggaatggatt tccataacca tgtttgaagg aatgcggcat 2460541 ggacgcataa ccatggccaa tcgacggcag tcttttttga taatcgttca tcatgccatc 2460601 acctgcctca caataacgtt gatttactat atgcaggcgc gcattttctt gacagctatt 2460661 tcgctaaact tggtccttct ccattgtata atgcatcaat agttccattc taagcatatg 2460721 ccattccccc ttcagttttt ttcgttgctt ttagcgccag tttgttaaat aaagatgctt 2460781 taactgagac tctttcattt catcataaat ttgttcaatc tgctgttctc gttcgaattc 2460841 ttccaggctt ttaaaccgtt ttttaatcgt taacgttaaa aagaataggt taatcgtcat 2460901 atcgctcacc ccctttcaaa gtccgcatca agcgaaataa cccgcggcac aacccttctg 2460961 ccgcgggcaa ataaaaaccg cagacaaaag aagacaccaa tgcctctact gcctgcgggg 2461021 agttgcgtat gtccgactat tccgaattta atgcgtgcga taagcatcgg ttaaggaagg 2461081 acacgaactc ttccacaggc tgaataaacc atgaactttt acatgtgtat cacgtacagg 2461141 ttgacgtcgt tgtctcattg tcattttggt tcagcctcct ttgctttttt cttactttgt 2461201 aagtatatcc accaaattcc attttgtaaa catctttttc taaaaatgga cggaaattgt 2461261 gcaaatcatc gaatggattt gcccgttggt catgacacct gcttcatttc ttttctggag 2461321 cggtctttct tatgatatgc aataaaataa atgagaccga caaatacagc tccgccgatg 2461381 acattaccga taaaagccgg aatgatgttt ccgatgaact gcccccacgt gaatgagcct 2461441 gcaaaaatgg cagcaggaat cacaaacatg ttggcgacaa cgtgctgaaa tccgatagcc 2461501 acaaaagcca tgattgggaa ccagatgcca aggatttttc ctgctgcgtc ttgggcgccg 2461561 aaagaaagcc acactgcaag acatacaagc cagttacagc cgatggcgga aatgagaacc 2461621 ttgccaaagc tcatatcaag ctttccttgg gcaacggcaa tcgttttttc taaataagga 2461681 cctgtttcag tcaatccaac caaatgcccg aaaaagtaag caacaaacaa tgcgccgatt 2461741 aagttcataa ttgtgacgat tccccagtta atcgctaact cttttactga tatttttctc 2461801 gaaaataacg ccatcgcaac tgacatcata ttgcctgtga tcagttcagc gccagcgaga 2461861 acgacaagga tcaggccgac tggaaatact gctgcaccaa tcaaactgga caggctcccc 2461921 cattctttcg gaagatcgcc aattaccctg atatcaagca aatacccaag cgcgataaat 2461981 gcaccgccta aaaaccccag cacaagcagt gacggcagcg ggagctttat ttttttcatc 2462041 cctgcttcaa ttgctgcttc cgctatttca tccggttttc gaaaagccat aataaaacgc 2462101 ctccattact tcttcttttc tcacagttat gcaagaaagg caataaaaaa ggcagcactc 2462161 aaataacctg tgtcaaacca ggcgtttgaa tgctgcctaa cttgtatgca tacccataca 2462221 acaatatcaa gcagtatata agatattgaa agagaatata tacagttcgt gcatacattc 2462281 cattgcttta gccttctata actgtagcaa catcatatca aatgtgacaa atttgtgtca 2462341 atgacaaata tactagcttt gcagagcttc tttttgctca tctatttttc ggtcaaaaac 2462401 aaatacagat acagcgatgt tttcctcaat tttaatatca gaaaacaaat ggactagctt 2462461 agctcccata agttcctcca ttccttccgg tgtttgtttg gaataaaggt cttgaattag 2462521 gcttgtccgg gccgcatgta ccatctctct tccttcaggc gtgcgggcaa taaactgctc 2462581 gcttgcactc agatttccgt atagtgttga aactgccatg ttttctacaa atacagtatg 2462641 aattctctca ggcccttttc cgaacaattc tttgcgaagt tttcgaataa tatcattgaa 2462701 ttcatgaatt tttttagaca tgctgattac cccttccgat attgccttat aaaggctttt 2462761 cccggttccc ctcaggacat ttcacttggt taaaattttc ctgccatatt gtattataat 2462821 aaatatcaca ttataataaa agcagtgttg atggatttgt aataggatct tgttatgagt 2462881 ctatcgtttt ataaaaatca aggattggtc tgttagtaag acttgctagt gaactattcc 2462941 gccatgtgtg tttacacctt cttagaatta agggcaggtg tatctataca tggctttttt 2463001 tgacttcttg aaagaaagat ggaggggaat atgaatatga tggacgttaa gtcgatcagt 2463061 gtccgtgtag acggaacaga aattcaagca cgagcagggg ccacaatttt agatatttta 2463121 aatgaaaacg gaattgagta cccgcagatt tgccacgtac cagaggttga cccgattcaa 2463181 acttgtgata cttgcatagt agaggcaaac ggcaagctgg ttcgttcatg cgcgacggtt 2463241 gcagaaaacg ggatgtctat tgatctttca ggaaatcgag tgaaagaagc gcaaaccgaa 2463301 gcgatggacc gccttcttga aaatcatttg ctgtattgta cagtttgcga taacaacaat 2463361 ggaaactgta cgctgcataa tacagcggaa atgatgggga tcgagcatca aaaataccca 2463421 tacacgccaa aagaagatcc ttcttgcgcg gttgatatgt ctcatccttt ttaccgctat 2463481 gatccaaacc aatgtattgc ctgcggccag tgtgttgagg tctgtcaaaa ccttcaggta 2463541 aatgaaacac tctcaatcga ctgggaacgc gaacgccctc gcgtcatttg ggatgaggga 2463601 gttccgatca atgaatcttc ctgtgtcagc tgcggtcagt gtgtaacagt atgtccatgt 2463661 aatgcactga tggaaaaatc aatgctcggg caggctggtt ttatgacagg cattaaagag 2463721 gacgtcatgg aaccgatgat tgatctcgtg aaaaatgttg aaccggggta tggcagcatt 2463781 tttgccattt ctgaagtcga agcggcaatg cgtgaaacga gaacgaaaaa aacgaaaact 2463841 gtatgtacgt tctgcggtgt cggatgttca tttgaagtat ggacaaaagg acgggatatt 2463901 ttaaagatcc agcctgtttc tgatgctccg gttaacgcaa tttccacatg tgtcaaaggg 2463961 aaattcggct gggattttgt caattcaaaa gagcggatca caaagccttt aatccgtaaa 2464021 aacggagcct ttgtggaatc ttcttgggaa gaagccctcg atcttgtcgc aagcagatta 2464081 ggatcaatta aagagcagta cggtaaaggc tctgtagggt ttatttcttc ttctaaaatt 2464141 acgaatgaag aaaactacgt cattcaaaaa ctagcgcgtc aggtatttga aacaaacaac 2464201 gtcgataact gctcacgcta ctgccagtct cctgctacag acggattgtt ccgcactgtc 2464261 ggcatgggcg gtgacgccgg cacgattaaa gatattgcca aagcaggcct ggtcatcatt 2464321 gtcggtgcca atccggcgga aggacaccca gtgctcgcaa cacgcgtcaa acgggcacac 2464381 aagctccacg gtcaaaaact gattgttgct gacctgcgta aaaatgagat ggctgagcga 2464441 tctgatctgt tcatcagccc taaacaaggc acagaccaag tttggctgat ggctgttacg 2464501 aaatatatga tcgaccaagg ctggcacgat caggcgttta ttgatgagaa cgtcaattac 2464561 tttgaagatt ataaagaaac ccttaaaacg tatacgcttg attatgcaga acgcatcaca 2464621 ggcctttcaa aagaaaacat cattcaaatt gctgaaatga ttcgtgatgc tgacggcact 2464681 tgtgtccttt ggggaatggg tgtcacacaa aatacaggcg gttctgatac atcagcagcc 2464741 atttcaaacc tgcttctcgc tacgggcaac tatcgccgtc caggtgccgg cgcttatcct 2464801 ctgcgcggac acaataacgt gcaaggcgca tgtgatatgg gaacattgcc tggctggctg 2464861 ccgggatatc agcatattac agatgacaaa gcacgcgcta aatttgaaga ggcatatggt 2464921 gtcgagattg atggaaagcc tggtttagat aatattcaaa tgcttcatgc cattgaagaa 2464981 ggaaaaatga aagctatgta tcttgtcggt gaggatatgg cactggtcga ttcaaacgcg 2465041 aaccatgtgc atgatatttt atcaagcctt gatttcttcg tggtacagga catcttcctg 2465101 tcaagaacag ctcaatatgc tgatgtcgtc ttgccggcca ctccttcact tgaaaaagac 2465161 ggaacattta ccaacacaga acgccgtgtc cagcgattgt atcaggcgct tccgacgctt 2465221 ggtgacgcaa aaccggactg gtggattatt caagaggtgg caaaccgttt aggagcgaat 2465281 tggaattaca gccatccaag tgacattttc tctgaaatgg cgagtctttc tcctctgttt 2465341 gccaaagcaa gctatgaggt gcttgaaggc tggaacagct tcctatgggg cagcttcaca 2465401 ggtgaaagca caccgcttct gtatgaagac ggatttaatt tccctgacaa aaaagcccgc 2465461 tttgcccttt ctgattggac cgagccagcg gcatttccgg aggaatatga ccttcatatc 2465521 aataacggcc ggatgctgga gcatttccac gaaggaaaca tgacaaataa atcgaaaggc 2465581 atccaagcga aagtgccgaa tgtattcgtt gagatctcac ctgagcttgc acaagagcga 2465641 ggtgtttgtg acggttcgct tgtacggctc gtttctccgt tcggagcagt caaattgaac 2465701 gcgctgatca cagaccgggt acggaaaaat gaactctatt tgccaatgaa ctcgacagac 2465761 aaggagtcag cgattaactt cttgacgggc cctgcagctg ataaacggac gaacacgcct 2465821 gcttataaac agacaaaggt ccgcatggaa gtgcttggcg gctgtgaaac agcgccgctt 2465881 ccaaaaacaa atccgcgcaa caaaaaacgg catccgcaaa acggagtcga agcagaaaga 2465941 aaatggaacc gccctggcta tgtacatctg actgattaaa cgataggagg aaaacgaatg 2466001 gccactccga ttacgacgat caaaaaagaa acaaaaacag ctgagcaaat taagcttgaa 2466061 aaaatagaag aactgaaaga gctgctggcg gaaaatgagg acgccgtctc taaaacgatg 2466121 acgttaatga atgaactcaa tgatcttgga atttttgatg cggcaacaag catgctcaga 2466181 gcgaaggaag acattgccaa gattgcgctt ggccaagttt cccgcgagcc tgtcaccaac 2466241 ctcatcaaca cgatgatggc cgccggaggc gcattgacaa aagccgatcc tgagtttaca 2466301 gcaaagcttt tagaaagcgt aatggctggg actgaacagg cacaaagctt tttaaaagaa 2466361 gacaagaaag tcgggattct cgacctgtta aaagcaatga acgatcctga catcaacaga 2466421 gccgtcgggt tcggccttca gtttttaaaa ggcatgggaa aagaacttcg agaacaataa 2466481 cagaaaaaca gccatctctg atgatggctg tttttttatt cgtcggcttc ttccagacgc 2466541 ttcttgtaaa taagtgaacg gtcagcgcaa aagaaggcac cggctaaaaa tacgcaatcc 2466601 gctaaaaaca tcgtcgattt ctggcctaat gttaagcctt gatcagggag aactgcgcct 2466661 atatataaaa aagtgctgac tgcaagcaat gtaaaagcaa aatgcttgta gtcttctttt 2466721 aaagatttca ttctattttt gttcaaaaga atcacctgcc agattcatag tatacgacta 2466781 ttataatata atccggcggc ttacagagaa agtaattcta tccatttgtt atatattttc 2466841 aagcgcttgg ccgatatctt ccaacaagtc ttccgcatct tcaattccta cagaaattct 2466901 gatcaagccg tccgtaatgc cgagctcaag ccggcgttct ctcggaatag aggcatgtgt 2466961 cattcttgca ggaacagaaa ttaagctttc aaccgccccc aggctttcag caatggtaaa 2467021 cagtttcaga tttcctaaaa acgcatcaac ccgttcttca ctgccaatat caaaggagat 2467081 catgccgccg aagcccgctc cttgcgtttt tgcaagctca tgtccgggat gatttgaaga 2467141 accagggtaa tataacgttt ggacagcagg gtgattctca agaaagcttg cgattttccg 2467201 cgcattttga tcgatcgctt ccattctgag tcccaacgtt ttgattcctc tcattaacag 2467261 ccaggaatct tgagggccga gcacgccgcc tgtggagttt tgcacaaaat gcagctcttc 2467321 tccaagctct ttcgaagctg tcacaactaa acctccgacg acatcactgt gtccgccaag 2467381 atattttgtc gcactgtgca gtacgatatc agcgcctaaa gtaagcggct gttgaaaata 2467441 aggagtatta aaggtattgt ctacgataag cagaacaccc gctttttttg cgatatcagc 2467501 catgagcgtc aggtcggtga ttttgagcaa cgggtttgtc ggtgtttcaa tataaattgc 2467561 ttttgtatta gggcgaatcg ctttttcaac ttcttccctg ctgctcgtat caacaaatgt 2467621 tgattcaatg ccaagacggt taagcacctt tgtcatcacg cgatatgttc cgccgtacac 2467681 atcatcagtc aacacgacat gatctccgct gttaaacagc atcataaccg ctgtaatggc 2467741 agccattcct gagctgaacg catagcctgc ttccccgctt tccagttctg tcacaagtgc 2467801 ttcgagagcg gttcgagtcg gattggccgt tcttgaatac tcgtagcctg tatgctgccc 2467861 tgctttcggc tgcttgtacg tgcttacttg ataaatcggc acggaaactg cgcctgtttt 2467921 ctcatcacct gtgattccgc catgtatcat caatgttttt ttcttcatat cagatgcctc 2467981 cttcgtatat ttgtttgctg atatatcgat cgctgctgtc aggaaatact gtgacaatgt 2468041 tagttccagc ggatgctttt ttcgcttcct ccaatgccgc ataaagcgct gcacctgaag 2468101 agcttccgat cagcaggcct tctttttctg ccgcttcttt cacaagtcta aacgcattct 2468161 catctgttac ggtgtagatc tcgtcaaaat ggctcttatc catataatcg gggataaact 2468221 ccatgccgat gccctctgtt ttatgagcgt ggggctctcc tccgtttaaa atcgagccca 2468281 ccggttcaac aatcaccgtt ttgactgctg gatttttttc ttttaagaag gaagctgtcc 2468341 ctgcgaatgt gcctcctgat cctgcccctg cgacaaatgt atgaatattc ccgtcaagcg 2468401 cttcccacat ttcaggtcca agcgtcttat agtaagtcga tggatttact cggtttttaa 2468461 attgcaaaac gcaataagaa ttttcaattt cagtctccag ctgaatggct ttttgaatgg 2468521 ctccctgcat tccgtcttga cgcggtgtat gaatgattga tgcgccaagc gcttgcataa 2468581 tttgctgttt ctctctgctg aaatgttcag ggacacagaa aatcgctttc agcccatatt 2468641 ttctggcact taacgcaagg ccgatccctg tattgcctgc cgtagcttct ataatcactc 2468701 cgccgggttt cactttgcct gaatcgagcg cgtcacgaat cagcatatct cccagtctgt 2468761 ctttgatgct tccccctgga ttcatcattt caagcttggc atacaccgcg actccttctg 2468821 gaacatcaaa gttcttcaag cggagaagcg gtgtattccc aatcagctcg gtaatgtccg 2468881 taatcactgt catatatgtc ctcctcctta atagaggttg tttttagaga aaaacggagg 2468941 agaacgttct ccccgtttta atgaattcgt ttgatcacct ttaacacaag ctctgttgaa 2469001 tgaacagccg cctgctctaa aaattggtca aatgaaacat gtgattcttt gcctgcgata 2469061 tctgataacg ctctgatgac gacaaacggc gttttaaatt gatggcatac ttgagccact 2469121 gccgcagcct ccatttcaac cgcgtacaga tcagaaaatc tcgcacgcac ctcttcaacc 2469181 cgcttcggat cgttcatgaa agaatcgcct gttgcaatcg ttccttttgc aacctgaatg 2469241 ccgtcgagtt cagataccgc ttcttcagtg atgctgatca gcttttcatc cgccgcataa 2469301 gcagccggaa gacccggcac ttggccgtat tcatagtcaa aagccgttac gtctacatca 2469361 tggtggcgaa cgtcagtgga aatgacgaca tcccctacat tcaatgtatg atgaaatccg 2469421 ccggctgagc ctgtgttaat gacataatca ggcttgtaac ggtcaagcag aagcgtcgtg 2469481 ctgatagcag catttacttt tccaattcct gattttaaaa gaatcacttc agttccttca 2469541 tattcgcctg ttgtaaattc acagtgtgcg atcgtttctg tttttgcatt ttcaagtttg 2469601 tttcttaaga tggtaacttc ctcttccatt gctccgatga ctgctagtct catctattca 2469661 cattcccttc actttaccgt ttgatcgcct ccattatcca cacgaagtcg ttttgctgag 2469721 tgaatcggac tgcaaaacct tcagctgtaa acatttcttt caacgcatcc aatgtaggat 2469781 aatgctctgt ctctaaatca tttgcaagct gataaaagcc ttgagaacgg gctttatcga 2469841 tagcctgttg atacgcttgc gcattttcaa agacggtatc ggcaaacact attttatcat 2469901 gcaagtgaag gtatttgcca tattgcttta tggcagcccg cttttcttcg tcagtcaaat 2469961 gatgaaaagc atatgaactg acaatcgtat cagcctgaaa tggcggctca gggaatgtca 2470021 ggaagtctcc atcaacgatt tccgtcctgc ctgagagctt gtcagaagcc agtttacgca 2470081 ttgctggaga aggttcgatt ccaaatacag ttttgcctgc atcgagcagc ttagctgtca 2470141 aattcccggt ccccgggcca aattctaaca catgcgttcc agattttctg acgatggcat 2470201 caaggatatg atcgtagcct ctgaacgctt ctttatactg aatatctaaa ccttgtactg 2470261 tttgatcata agttgctgcc caatcttcaa agagagggat aaattcacgg cccatatttg 2470321 tcacactcca tatttaataa ttcctataag tatactatgg attaatgatg gaacagttcc 2470381 tataatacca catattctga aaagcaggta ctaaaacact ttgtgtattt tatgccatct 2470441 catattgcgc attgaccgca aaaaagctta tacttcatat gacttgtgaa agctggaggg 2470501 tcaagacatg aattttcaat tagatctgat taaagacaaa gtggaatttt ttgaagcggc 2470561 ttcattgcag gagcttgaaa agaaaatcaa tacacaaatt gaaaacaata aagccatcat 2470621 gctccgggtg aaatctgttt cacaccaaac tcttgtggca gaaggaagaa tattgtacag 2470681 cgcggtggtt catttctcag ctgaagccta aaacaaaagc agccggtttt aacccggctg 2470741 cttttgttta ttttagcttt tctacttttg tcggcttcca gcctttttca tcgacccatg 2470801 taatcgtgac ttgatattta ttcccagtcg ccttgtccaa aatcttgcct ttggcatcct 2470861 gagggctgcc gttatttcca agccagagca ccgtcatgtt atctgttgag acaccagttg 2470921 cgtacgaaat ggctttcagc atctcagccc agtcttgtga gcttgaatca taagtagcgg 2470981 catgctcgcc agtctgctca gttccgactg ctttccagtc aggattttca tacgtttttt 2471041 ccacatcgct cgatgagccg ccttctgtta cttttgcatc tttaagcccg tcaccggctg 2471101 aatctgagct tgaatctgaa tcagagtcat cttttttaga agaagaatca tcttttttgg 2471161 aatcagagtc agaagacttc tcagaatcct tttcgctgtc agatgtatct ttcttgctgt 2471221 cttttatatc ctcatccgat ttcttttccg tctttcctga agccggagat tcctgttttt 2471281 gcgccgtttc agaatccttg ctgacatctt tgctagaagg actgttaatg aagagattcg 2471341 ctgctactac gacaattagt atggatacga ttgcgattaa aatgttaagc actaaattgg 2471401 cttttctgcg tttatcacga ttttcataac gagattgatt attgctcaat aattctgcac 2471461 tcctttatcc ctcttggctc agcatatatt ttaacatgtg ctgagaagtt gttctatttc 2471521 tgattgattt caatttcgtg tactttttta acaatatcat aaaacaccga atttgtcaga 2471581 gccttatctc ccggtgtatc catgtgtaaa acaactagag cgtatttcgg cttatccgcg 2471641 ggaaaatatc cggcaaacca tttttcgtag agcgtttcct tctcttttga aagcttgcct 2471701 gtctgggctg tgcccgactt ccctgctaca gtatacggaa gatcttgaaa ccttctgccc 2471761 gttccggaag gagattctac tacccgccgc agtatttttt gaagctgctg tgacgtatat 2471821 ttgtctatcg tttccccttt gagcttctga tctttaaacg taacgagcgt tgtgccgttc 2471881 ttatactcaa tttgttcggc aattttcacc tgccgttttt ctccgccgcg ggcgattgtc 2471941 gccatcatat tggctacctc cagcggcgtt acctttacat ttttctgccc gattgctgtt 2472001 tgcgcaatgg cttttttgac tgatttgtct ttttcatccc cccaaatcac gccgcttttt 2472061 tcgttataca gctggcggaa atcggtttcg tggtacagtt ttccctccca gcctgcccga 2472121 tcagtgagag ccagcttctc ggacatatct tcaataaccg agctgtcttt tttcattaat 2472181 tgttctgcaa gactcgtaaa tgtgtaatta cagctttggg caaaactttc atcaaaagac 2472241 aaggtgcctt tgtcgtcccc cggttccccg tacaggttta aattgcaatt aaaggtttga 2472301 ctaggcttca ccatattatt ttcgattgca gctgcggcaa tgactgtttt aaaaactgat 2472361 ccgggataga ttggcgtcag catataattt tgaagtgtgt tttgccggga cacgtctgca 2472421 tctggtttgc ttacaattcc cagaacactg ctattttcga tgtccagcag cacagctcct 2472481 ccctttttca gcccctgttc atccaatacc tcctccatcg ctttttgaat gctttgatcg 2472541 atcgttgttt tgatctggag cggataaaat gtattggctt cagctgtata tttgacgtcc 2472601 atgccaaaca aagggtttcc ttttccgtcc acatgatata aaagctttgt gtcttgttcc 2472661 ggaagcaaaa actcgtcaaa tgtccgttct aaaccggttg ttccgatttc tgttgtaatc 2472721 ggaaggctct ccttgtcagg atatttcttg cgaagcagcg ccggatcttg gttcgtgctc 2472781 cctatcgtat gtgaagcaag gctgggcttg tcttcattct ccatatatac gccgtaaatg 2472841 ccgggatatt tcaaagaatt gatttttgtg atagattgtt ttgaaagtgt tttgattttc 2472901 ttttgctgca aaatgaccgg tttttttgcc tgacctagtg tctggcgcaa atcatcttca 2472961 gacatgccga ggatgtccgc aacttttttg atcggccaat cctgcgtcag cagaaaaggg 2473021 aacaaaacaa ccgcaggctc gctttgtcct gtcagcgccc gcccgtttcg atctaaaaaa 2473081 gagcctcttc catctgaaat gagcacttcc tccgtccgct gtttcacact ttcttgaatc 2473141 aaattaattt tctttttaga aaatgattct gtgaaaaaca gctggatttc tgcaagtctc 2473201 agcagaagca gaaaaaatac aatcaaaaaa gcgatgactg ccagcttcat tcgtttcgat 2473261 atcttcataa aaaaacacct cacccacatt gtggacgagg tgtttcgctg ctaaacagat 2473321 attatgaaat tttcacaatt ttcacgagca tttctccgcc cggtgtttgt actgtgactt 2473381 cttcatctac ttttttgccc aagaggcttt ttgcgatcgg tgaatcgttt gagattttcc 2473441 cttcaaacgg gtcagcttcc gcgcttccga cgatcgtata tgattcttca tcaccgtcag 2473501 gcagttcgac gaaagtgacg gttttaccca aaccgacaac gttagagccg ccgtcatctt 2473561 caatgatttt cgcattgcga atcatatttt caagagtcgt cacgcggccc tctacaaatg 2473621 cctgctcttc tttcgctgaa tcgtattcag agttctcgga aaggtctccg aagcttctcg 2473681 caattttgat tcgctctact acttcttttc gtttaaccgt tttcaaatat tctaattctt 2473741 gttcaagttt ttgttttcct tctgcagtca taggaaaaac tttctcttgt gccatgtccc 2473801 ttcactcctt ctggttgtcc ctcaacatct tcgattatgt atgagagcat aaactaaaaa 2473861 atacaagaat gagaacacag ggcagtcctc gttcttctct cccatatagg tactgtttat 2473921 cttaaactga atcgtgtcgt tctgcaaata tttcgcgttt ataaacaggg aaagaaggga 2473981 attcgcacat tcccttcctg cctatacata atatggtcag agttatttat gtctatgcta 2474041 tggtattaca aaatcgcgtt ttgttcaaga atggtttgaa tttttgtgac catcagatca 2474101 attgcgacgt gattctgacc gccttccggg ataataatat cagcgtatcg tttcgtcggc 2474161 tcgacgaatt ggttatgcat cggacggacc actgacacat attgttcaat gacagaatca 2474221 atagagcgtc cgcgctcatt aatatctctc ataatccgtc tgatgatacg caagtcagcg 2474281 tccgtatcaa cataaagctt gatatccatc agatcacgaa gccttttgtc ttcaagaaca 2474341 agaatgcctt caaggataat aacatccttt ggctctacgt gaaccgtttc ttctgaacgt 2474401 gtgtgaagct tatagtcata aatcggcttt tcaatcgggc ggtaattcaa tagatcttga 2474461 atatgctcga ttaaatagtc attatcaaac gcaagcggat gatcatagtt tgtgttcagc 2474521 ctttcttcaa acggaagatg gctttggtct ttataataaa ggtcctgctg gatcattaaa 2474581 attgagtgtc ctttaaactg ttcataaatg gaccgtgtga cactcgtttt tcctgaaccg 2474641 gaacctcctg cgattccaat gactactgga ttcttaccca tgggctgtta cttccccttt 2474701 ctcatcatgt tgctcggata aatctttttg tctagtttga atttgacaat ttgcagggga 2474761 tggcgggcag catctagctc atttccgtct tcgtcccaaa tggtttcaat cgtatgtgta 2474821 aagttttcga tttctggacc gaaaaattcc acttcgtcgc cttttttgaa gaaattgcgc 2474881 tgctgaagcg tgaccatttg tgtatcttca tcataattca gcactaagcc gacaaaatca 2474941 tatgtcgttt tcttggcgtg ttcgccgaac atttgctctt catagcctgg cgttccttca 2475001 aagaaagctg tcgcagtgtc cctgttggcg cacttatcaa gctcttcaag ccattctttt 2475061 tgaatcacaa agttttctgg atcagcgcaa taagcatcga ttactttgcg gtatacgctg 2475121 acaacagttg ctacatagtg aatggatttc atgcggcctt caatctttaa gctgtcgatc 2475181 cccatttcaa tcatttttgg aatggattca atcagcttca aatctttcgg gctcatcgca 2475241 aatggtgcat cttcttcacc atacaaagca acggcgttgg caccgtctgt ttggtagaga 2475301 tcataatccc agcggcatga ctggcagcag cctccgcggt tggaatcccg cgctgtcatg 2475361 tgattgctca gcacgcagcg gccggaatat gcaatacaca ttgcgccatg aatgaaggat 2475421 tcgatttcga tatctacctt ttctttcatt tctctgattt caagagcgct agtttcacgt 2475481 gccagcacga cgcggtcgag accttcttcc ttccagaact ggacagcctt ccagtttgaa 2475541 agagactgct gtgtgctcaa gtgaacctca acattcggcg ccactctgcg gcatgtttca 2475601 ataataagcg gatctgccac aataataccg gcaacgttgg cgtctccaag cgcttttaaa 2475661 tagtcttcaa gcccgtccat gttttcatta tgagcgaaaa tattcgttgt tacgtagatc 2475721 ttcgcgccat atttctttgc gaattcaacg ccttctgcaa tttcttcgat cgtaaagtta 2475781 tcggcattcg agcgaagccc gtattcctgt cccccgataa agaccgcgtc cgctccgtaa 2475841 tgaacagcga ttttcagctt ttcaagatta cccgcaggtg cgagaagctc cggctttttc 2475901 gtaatcacac gctttccatt aacgattgtg gatattttat catttacggc agtcatagct 2475961 taacctcctt ttgattaata aaccgtttcc ttgaagaaga atccggtatc aatttttctg 2476021 tttactggct ggatgctttc aatgcgttcg atccagtctt cttttttcgc ttcgtattcg 2476081 tcacggtttt ccacgcacaa atcaattgct tctctgtaca ttttggtgac ttctattagg 2476141 tattcaggca ttttcaaaac accatcgatt ttgaaagaat caattccggc atctatcaat 2476201 tcctcgagct catcaatgat gcacacatcg ttcgggctca tgatgtgagt gccgttttca 2476261 tcttcgaaaa tcggatattt attatcgcgt tctttatcgt gtaaaaacat gcctgattct 2476321 tttttctttc tttcaatgtc catgactttg ccctgatatt caaaatagtt tccaatcaaa 2476381 gaacgcttcg attggaacat gcacgtcatt ccatgcacct ggatttcaat ttcgacttca 2476441 gcattttctt taatctcaac aatgctgtcc atgtttaatt ctctggcaag cacagaacgc 2476501 gccgcaccct tgcgtcccca gtagttgcat gtataatagt tggtgcctgt cgtttctgtg 2476561 ctccaatgaa gcttcagatc aggcgcagat tcacgggcag ccatcagcac ggcaggatcg 2476621 ccgaataccg ctgcatcgac accggcttct gctaagaaag ccagatattc gccaagctca 2476681 cccactttat cattatggaa aattgcattt acagcaacgt atacttttgc cccttctttg 2476741 tgagcaatct ctacggcttt tgttacatct tcacgagaaa attctccggc taatctcaag 2476801 ccgtatctct gttccccaac taaaaacgca gttgccccag cctgtatgag cggcaaaatg 2476861 tccgctgtac tcgtcggcgt cactaagagc tctggttttt tcatgacgtt cacctcttct 2476921 ttttactaat cgcaagtccg tccccgacag gaataatcgc agtttgataa tccggatgat 2476981 tcatcagcca atgattatat tcatcaattt tggctacaag cctgcgcctt ctcttcggtt 2477041 ctattttgct gtaatcctct gccaccagac ctttaaacag cacgttgtct gttataatca 2477101 ccccgtccgg tgaaagcatc ggttcatata aatgaaaaaa gttttgatac tgaccttttg 2477161 cagcgtcaat aaaaatgaca tcgtaaggcg cggttacatg aacggcgtcg gctaattcaa 2477221 gcgcatctcc gtaaaaaaca tgaatccggt catcaagctg aaattccttg atattgttta 2477281 ccgcttcttc atgccgtttc tcattgcgtt caattgtata tatttcagca gacggcagtt 2477341 ccagagccat tcgaatggct gaataaccaa tggccgttcc gatttctagt atttttttcg 2477401 gctgtttcac agacaaaatt tgaagcagca cctccatgcc cgctttttcc ataatcggga 2477461 catgatgttc ttctgcatat gcttcaagtc tcttcacgtt atccggccga ggctttaata 2477521 atgcttctat atagtcattt atttgttcat accggtcagt cactacaaac agcctcccgt 2477581 tctaaaaagg agtgccccag tcttatgcgc aggacactct ctgaatacat catgatacat 2477641 cggtaaacaa cccgatatat tttatcataa aaccttgcgg aaagcgaaca aaaggagagc 2477701 tttttgctct ccttttattt ctcatttttt gaggaaatgt atttttcttt tgctttatta 2477761 tgctctttta gcgtttttgt aaatacgacc tcaccatttg atttggccaa gaaatacaga 2477821 tagtccgttt tatccggatg cagcgctgct tcccatgatg acatgccggc attggcaatc 2477881 ggccctggcg tcagccctgt gtttttatac gtattgtatg gtgaatcgat ttccagatcc 2477941 ttataaagaa cccgatcttt atgcttgcct gccgcgtaca ggacggtcgg atctgtttgg 2478001 agcggcattt tctttttcag gcggttataa aagacgctcg caattttatg gcggtcggct 2478061 ttttcagtcg cttcttcttc tatcaaagaa gccattgtca gcagcttatg cacagaaact 2478121 ttgtttttct tcatttctga tttatatgtt tccacataag aatttgtctg cttaatcatt 2478181 gccttgataa tgtcttcaag tgatgtgtcc ggatcgttaa aagggtatgt agccgggaat 2478241 aggtaccctt caagcgggtg cttaatgttt ttattgaaaa catcatttgt cacagtgtcc 2478301 gggaattctt tcttcagctg attgataaat gtttcatcgt ccagcttcgc tatgacttgt 2478361 tttttagagt attttgtttc atcagcaata gcagccgcga tttgggtcag ctgtgctccc 2478421 tcagtcactg tgatttgaaa agcgtaacct gtagccccgc ttgtcagctt ctgaataatg 2478481 gcatctaaat ccataccttt attcagatgg tagaatccgg cctgaaaccc ggaagcacct 2478541 ttatatttca catagtactg aaacgccttc tcgcttttta tgacatcatt tttctttaat 2478601 atcgatgcga tggctgaaac agacgaaccg ctcggaatgt taatattaac tgtcgtttta 2478661 ctgtcttttt caacaggttc aagcaatgat ttcccatata aaaatgcccc gccaatgatg 2478721 agaaacagca caacaatgga agacagtatg attctttttt tattaaaaaa cgattttttt 2478781 tgctgattga tatacattag gtctcctccc atcagctctt atactacatg attcattgta 2478841 tttcggcaat ttattacaaa aagaggcctg cataaagcag aaaaaagccg gagcagtata 2478901 gctccggctt tggtttggcg cgatgtttta ctcttcgtct tcgtccgcta agaatgtgtt 2478961 tagtgtttct tcgatcatat cccattcttc gtcagtttca atcgggaata gctcaccgtt 2479021 ttcaccgtct tcgtttggcg tgaagctgga agcaagaatt tctacttctt cgtcatcttt 2479081 tgattcgatt ggatagtaca agacataaga tttgccaaac tcttcatttt caaatgtaaa 2479141 cagcacttca caaagctgtt catttccttg atcgtcaaca attgtaatat ttttttcgcc 2479201 gtgttccatt ttcttcacct ctggctttaa tttaagctgt caagatatcc ttgtaaaatc 2479261 ataacagccg ccattttatc aatgactttt tttcgttttt gcctgctgac gtcagctgca 2479321 atcagcattt tttcagccgc cattgtggta agacgctcgt cccacagcac aacaggaaca 2479381 ttgtacgttg tttcaagcac tttcgcaaat gtttggctgg cttcgcctct cgggccgact 2479441 gttccgttca tgttcttagg aaagccgagc acgattttat ctatagtata gtcctttatc 2479501 agttcagata aacgggataa accataatcg ccttctgctt catttatctt tatggtctca 2479561 atgccttgag cagtccagcc catttcatcg ctcagagcta caccgagtgt tttggttcct 2479621 aaatcgagtc ctaatattct cattctttat ttacgcctct ttatgctgtt ctaaataaga 2479681 ctttaccaat tcctcgatta attcgtctct ttcaagtttg cgaattaaat tgcgagcgtc 2479741 acgatgccta ggaatataag cgggatcacc tgacagcaag tatccgacaa tctggttgat 2479801 tggattgtag cccttttcct gaagcgcgtc atacactgta atcagcacct catttacgtt 2479861 agtctcagca gaatcatcgg agaaattaaa tttcatcgtt ttatcaaacg agctcaccgt 2479921 tttgcacctc tttcccaaat tcgcaggcaa agttcagcct ggggtcctaa tcttaccatc 2479981 attctacact acatgggcga attataaaac ggatttcacc caatcttcta cagaagccaa 2480041 agcttcttct aatttttccg gctgtttacc gcctgcctgc gccatgtccg gacggcctcc 2480101 gccgcctccg ccgcaaactt ccgcagcttg tttaaccagc ttgccggcgt gaagtccttt 2480161 ctcaatgagg tcctttgtga ctccggcaga gatattaact ttatcgtttt gtaccgcacc 2480221 aagcacgatc accgcagagc caagctttgc tttgagttca tcgaccatag tgcggagatg 2480281 attcatgtct tttgcattta cttttgccgc aagcacgttt acgccgtcaa cttcttttac 2480341 tttcgacagg attgctcctg cttccacgtt gcctagtttt gcaagaagag attcattttc 2480401 tctttgtgca tccttcagtt cagcctgcag agccgcgacc cgtttcggca cttctttgat 2480461 atttgttttc agctcgtcag cggtctgctt caatacagaa atctggctgt tcatttcgac 2480521 gtaagcgcct tgtcccgtta cagcttcaat ccgtcttgtg cctgctccga ttccggattc 2480581 agaaacgatt ttaaacaagc cgatttctgc tgtatttctg acgtggcagc cgccgcacag 2480641 ctctaagctg taatctccaa cttgaacgac acggacaata tcgccatatt tttcgccgaa 2480701 cagtgccatc gcacccattt cttttgcttc agcgatcggt ttcaaatcaa tgctgaccgg 2480761 gatgctcgcc cagatctttt cgtttacgat tctttcaatt tgttcgagct cttcttttgt 2480821 cacttggcca aagtgcgaga agtcaaaacg aaggcggttt tccgttacaa gagagcccgc 2480881 ctgattgaca tgagttccaa gaacatcttt tagagcctga tgcaataaat gcgttgccgt 2480941 gtggttttta atgacgccgc ttctcatatg gtcttcaact tcagccgtaa catgcaggcc 2481001 tttttgaaca gtaccgctct ccacaacacc ttcatgcaca tgctggccgt tcggcgcttt 2481061 ttgaacatct ttaattctta caactgcctg ctcgcttcgg agatagcctt tgtcgccgat 2481121 ttggccgccg ctttctgcat agaacggtgt ttcatcaaga atgatttgaa cgctttctcc 2481181 ttcatgagcc tcttcgatta attggccgtc ctgaagaagc acaatgatat tggcatcagc 2481241 tttggtttga gagtagccga caaatgtgct ttcaactgtc acgtcgcgca gtgcgccgcc 2481301 ctgcacctgc atgctgccga catcctggcg ggcgtttctt gcccgttcac gctgctggtt 2481361 catttcctcc tcaaagccct catggtcaac cgtcatgttc tcgtcttctg cgtattcttc 2481421 agtcaattca accgggaatc catacgtatc atacagttta aacacatcag cacctgagat 2481481 aacgctgctg cccttgtctt tttctttttt gatcatttct gacaggatcg caagcccttc 2481541 attaagggtc tcatggaagc gttcttcctc ggttttaatg acttttgcga tgaaatccgc 2481601 tttctctttc acttcaggat agaaatcagc catgatttct gcgacaaccg gcactaaatc 2481661 aaacatgaac ggacgatgga tgttgatcgt tttggcataa cgcacggcac ggcgtaataa 2481721 gcgtcttaat acatagccgc ggccttcatt tgacggcagc gcaccgtcac tgacagcaaa 2481781 ggcaaccgtt ctgatatggt cagcaatcac tttaaacgca gtgtctttca cattgtcttt 2481841 gccatatgtt tcaccagaaa tcgattctgt tgctttaatg atcggaacaa acaaatcggt 2481901 gtcaaagttt gtcggaacat tctggatgac agacaccatt ctttcaagac ccatgcctgt 2481961 atcaatattt ttctttggaa gcggtgtgta cgtgccgtca gggttatggt tgaactctga 2482021 gaacacaagg ttccatactt ccaggtaacg gtcgttttcc ccgcctgggt aaagctccgg 2482081 atcttctgga tcattaccgt atgcttcacc gcggtcgtaa aagatttccg tattcggtcc 2482141 gctcggccct tcaccgatat cccagaagtt cccttccaga cggataattc tttcttcagg 2482201 aataccgatt tttttcgccc aaaactcata tgcctcttca tcttcaggat gaaccgtaac 2482261 agagagaagc tctttgtcga agccaatcca cttgtcgctc gttaaaaact cccaagccca 2482321 tgtaatggct tcttctttga aataatcgcc gatggaaaag tttccgagca tttcaaagaa 2482381 agtgtgatgg cgcgcagttt tacctacatt ttctatatcg tttgttctga tcgctttttg 2482441 agcgtttacg attcttggat tttccggcac gacacggccg tcaaaatatt ttttcagcgt 2482501 cgcaacaccg ctgttgatcc aaagcagtga aggatcctca tgaggcacta atgacgcgct 2482561 tggctctacc gcatgtcctt tttctttaaa gaaatccaaa aacatttgac gcacttccgc 2482621 agaagttaag tgtttcattg tatttcctcc tctataaaaa tcgaaattct cttcagtgac 2482681 agcaaaaaag ccctccccct atgcaaacca acgtttacac agggacgaga gctgtctcgc 2482741 ggtaccaccc tgattacggg cattcatgcg cccgtcacct ttaaccctgt aacgcaggat 2482801 aagcggcagt gattaactgc actcaggatt agcttcctcc gatcttctga taaagctcct 2482861 ttcagcttat ggagcttctc tctttaacag ggcttcggcg tactcagatc cgtcactcga 2482921 gattcgtatg tattctacga gaaattatag acaagcggca cgccgatgtc aatgctccgt 2482981 cctcatccgc aaaaaatgga tcatcattac ttttaaaaca gccgtcgcag gaacagccag 2483041 aatcatcccg acgatacccg caagctcccc tccggcaagg agtgcaagca tgataacgac 2483101 cggatgcatt ttaaggcttc tgccgacaat gaacggactg aggatatttc cttccataaa 2483161 ctgcagaata aacaccgtaa tcaccacaac aagaaccgcc ttgactgaga tcgtcatcgc 2483221 aattaacaac gcaggaacag ctccgatgaa agggccaaaa tacgggatga cattcgttac 2483281 cccagagata aggccaagta tcagcggata cggaagccca aatacccaga acgaaatgcc 2483341 tgcaatcacg ccaagaatca agcagaccaa aagctggccg cggatataat cgccaagcga 2483401 atcatccaca tcccgcaaaa aggcgctgcc ccgctttctc cacgacttcg gagtcaagta 2483461 ccatactgtc tttttcatta actcaatgtc cttcaccata taaaacacga gaaaagggat 2483521 tgttgcagca attaagaagt aatcaagcac attgcggatc ccgctgatcg caccctcgat 2483581 cgttcccgca aaaaacgcct ccgtctggcg gatcatttta tctatacggt gatgcatacc 2483641 atcaggccag tcatccgtat ggttatgcac atgaagaaga agcccgttat acgtttcggc 2483701 aaacatgggt atattttctg acaaatccgt cagctgcacg attaaaacag gcaccccttt 2483761 atacaacgcc cagccaatcc cgccaaaaaa aagaacataa atgaccaaga tgctcaaagt 2483821 cctaggcaat cctttgccat gcagccattc tgtgaccgga agcaataaat aagatataaa 2483881 aatagaaatg atcaagggaa taaagatcgt ttttatgacg agccaaaagg gtgaccataa 2483941 catatcaagc ataaaaaaga catagactgt taacagaacc agcaaacaaa tagccaccca 2484001 caacaaaagc tgcaccggtt tttggagcat ctgctttcac ctcacctata tcttttgagg 2484061 tttacaagga attattcttt atgtttcttt agtcagtcag aagtcatgga cattttttca 2484121 cttttaattt tcagaaaagt ttgatcattt actttttggt caaattttct gataggagga 2484181 ttgcgatgat cacatttcaa aatgtaaaca agcattacgg agattttcac gtgttaaaac 2484241 aaattaatct tcaaatcgaa aaaggtgaag tcgttgttat catcggccca tccggttccg 2484301 gtaaaagcac attgctcaga tgcatcaaca gacttgagtc gatcaatgag ggagtgctta 2484361 cagtaaacgg caccgccatt aacgacagaa aaactgatat caatcaagtg cggcaaaata 2484421 tcgggatggt gtttcagcac tttcatttat atccgcataa aacagtgctg cagaacatca 2484481 tgctggctcc ggtaaaagtg cttagacaat cacctgaaca agcaaaggaa acggcgcggt 2484541 actatcttga aaaagtcggc atcccagaca aggctgacgc ctatccttcc cagctttccg 2484601 gcgggcagca gcagcgtgtt gccatcgcaa gaggactggc gatgaagccg gaggtcatgc 2484661 tgtttgacga gccgacatca gcacttgatc ctgaaatgat cggtgaggtg ctagatgtca 2484721 tgaaaacact cgccaaagaa ggcatgacaa tggttgtcgt gacacacgaa atggggtttg 2484781 ccaaagaagt tgccgaccgg attgtcttca ttgacgaagg aaaaatttta gaagaagcag 2484841 tgccggctga attttacgcg aacccgaagg aagaacgggc ccgcttattc ttaagccgta 2484901 ttttaaatca ttaaaacaga aatgggggag cttgtatgaa aaagattttt tctttagcat 2484961 tgatttcttt attcgctgtc atcttgcttg ccgcttgcgg cagcaaggga tcaaacggag 2485021 aagcctcaaa ggagagcaaa aaagatacgc tagccgccat taaagacaat gacaaaattg 2485081 tcttcggcgt aaaaacggac actcgactgt tcggtcttaa aaatccaagc tcaggtgaga 2485141 ttgagggttt tgatattgat attgctaaac aaatcgctaa agacatttta ggtgatgaga 2485201 aaaaagctca atttaaagag gtcacctcaa aaacaaggat tcctatgctg caaaacgggg 2485261 atatcgacgc cattgtcgcc acaatgacga tcactgaaga acgaaaaaag gaagttgact 2485321 tttctgatgt ctatttcgag gccgggcaat cgcttctcgt gaaaaaaggc agcaaaatca 2485381 agagtgtcga gaatcttggc aaaggctcaa aagttcttgc agtaaaaggc tccacctcct 2485441 ctcaaaacat tcgtgaaaag gcgcctgaag catctgtttt agaatttgaa aactacgcag 2485501 aagcctttac agcccttaaa tcggggcaag gcgatgccct caccacagat aatgcaattt 2485561 tatatggaat ggctgatgaa aataaaaatt atcaattaac aggaaagcct tttacagatg 2485621 agccttacgg gatcgccgtg aaaaaagggc aatctgctct cgcgaaagaa atcaacgctt 2485681 cacttaaaaa gatgaagtcg gatggcagat acgatgaaat ttataaaaaa tggatcaaag 2485741 aagacccagc tgaataacaa ccatcccggg atgagcaggc gatgctcatc ccaatttgat 2485801 aaggagtgaa taggcagatg aatgtgtcaa ttcttttcga taacttcagc atgtatatgg 2485861 acggttttta ccataccttg ctcgcaagtg ttatcgcgct ggccggcagt tttgtcctcg 2485921 gcgttgctgt agcggttatg agaataacag tctttaagcc gctgcaatgg ctcgggaccg 2485981 catatgtaga attcatccgc aacatccctc ttcttttaat tacctttgtt ttctatttcg 2486041 gacttccaaa cgcaggcctg aggcttgacg gttttcaagc gggaacggtt gctctcacca 2486101 tttatacctc tgcgtttatc gctgaagcca tcagagcagg catccagtct gtttcaaaag 2486161 ggcagatgga agcggcacgc tcgtcaggct ttacctacag ccaagccatg ctccatatca 2486221 ttttgccgca ggcaatcaaa atcgtcattc cgcctttagg caatcaattt ttaaacttag 2486281 tcaaaaactc ttcgattctt ggggttgtgg ccggattgga tcttatgtac caagccgatt 2486341 tagtttcgtc gagcacactc gttgtatttg atgtttatat ttttgtggcg cttttttact 2486401 tagtgctgac gattccgctt agcatcggtg ttaactatct ggaaaaacgg ctggaaaaaa 2486461 gctattgata aggagtgagt tacattggat ttcatcggtg cttattcaca ggagcattta 2486521 gcgtttttat gggatggctt tctcgtcacc ttgtacgttg ctttcatctc catcattctg 2486581 agctttttct tcggtttaat cgcaggcacc ctgcgttatg cgaaagttcc cgttctttct 2486641 caattgattg cagttctcgt tgaaacgatc agaaacctcc ccttgctgtt aattattttc 2486701 tttacgtttt ttgcccttcc ggaaattggg attaagcttg aaattacagc tgctgcaatt 2486761 acagcactaa cgatttttga atccgctatg ctatctgaaa ttatccgaag cggactgaaa 2486821 tcaattgaca aaggacaaat tgaagcggcg cgctcctccg ggctgagcta tacacagacc 2486881 ctgttcttta tcgttatgcc gcaagcgctt cgccgcatgg ttccgcccat cgtaagccag 2486941 tttatttctt tattaaaaga tacatcgctc gctgttgtga tcgccctgcc tgaactgatt 2487001 cacaacgcgc aaattattaa cggccaaagc gctgacggca gttatttttt cccgatcttt 2487061 ttacttgcgg cccttatgta tttcgcagtc aactacagcc tttcactcgc agcaagacgc 2487121 ctcgaggtcc ggcaaacata gaaaaggata ctctttggag agtatccttt ttgcattaaa 2487181 acattttcgt aattcttctt ctcatccgct tcatgcttcg attattcagc atgtcagatt 2487241 gagtcgccat tcggtacacg agagctccgg ctcccattgc caaaagagaa gtcatcgtcc 2487301 gattcatcct gcgcatctcc tttcatgatt aaaaattgat gctgcgttca tcctcagaaa 2487361 acaaatcatc caagctgctt aacgttccgt cttcttccac ctgatgagtt gcaatcttcc 2487421 ctttcgccac tgtcagttca ataaaacagc cccagcaata atattggttc acgccgattt 2487481 tgccgatatc cttacttttg caattcgggc atataagcat acctcacacc tctatccgtt 2487541 cagaacgatc tcgtctttcc gcacctcgac aagcgaatcc gctctttgga tctggcgctt 2487601 gcttcccgcc aggtcagaaa agaaaccgtc cgagagttca tatgctacga ttatgcccct 2487661 gtccaaacaa aagtatacat cttccagcat ccccaatata tccccctctt gcgatttcac 2487721 aagcttcatc ttcatctgct cgtatgtgaa gcatgatttc ggaagaggca aaagctgttc 2487781 tgaactgacc gaagccaata tgcggtcatc aaaaatggaa gagatatcac acgcccgtaa 2487841 tagcgcatga tgatgatgca aaaagcgttt ttgtgcaaga ataaacccaa gacaatctcc 2487901 tttcagagaa aaacaaatat cggaaattgt cccgagataa ctagaagttc gttctgagta 2487961 tactgggaat ccttctactt catggcatgt tctcaaagtg tgatcaacca ccttttgttg 2488021 aacaggctta ggttttgctt tgcgccttag actcatacga tgaaatcaat tccactgcaa 2488081 atgaaaaaaa actcccgctt gcacgggagc attttattgc tgttcttctt tcataaaatc 2488141 gaatggtgta atgccttcca tgccaatgtt ggcgtcgtgt acgctgaacg ggagctcttt 2488201 ttgcaaagct tcaagctcgg catccatttc ctcaacctgt acggacagcc tgtttttcaa 2488261 ggaggtctgt ctgacagttg catcattatt tttcacgccc cactccagcg cctcctcttc 2488321 cccgcataaa atgagaaatt tcttcgctct tgtaatcgcg gtataaagaa ggtttcttct 2488381 gagcattcta taatagcctt tcacaacagg caaaaccaca atcggaaatt cacttccctg 2488441 cgatttatga atagaacagc aatacgcatg ggtaaattga ttaaaatctt ttttcgtaaa 2488501 tgtcatttca ttgccgtcaa aagaaacgac ggccatgtct tctttttctg tattttcctt 2488561 tgcataaaat atcgacgtga tttcgccaat atctccgttg aacacattgt tttccggctg 2488621 attgacaagc tgcaaaattt tatctccggt tctgtagaca acatccccga acttcaattc 2488681 tctccgtttt tctttaggag gatttaaaat gtcctgcagc atcacattca attcattaat 2488741 gccggctttt cctctgtaca tcggagcgag gacctgaatg tcctttgctg tatagccttt 2488801 tttcaatgca ttggcgacaa ccttctcaac tacttctttg atttgcgacc cgccgcagcg 2488861 aataaaggaa cggtcctttg tcggggcagt caaattgttc ggcagcaatc catttttcat 2488921 ctggtgggca agctcgacga ttgatgaccc ttctgcctgg cgatagatgt ctgtcagtct 2488981 cacagtcgga atcacctggg atgccagcag gtctctgagc acttgtcccg gaccgacgga 2489041 aggcagctgg tcttcgtctc cgacaatgat gatttgtata tgatcaggga tcgccttgaa 2489101 caaatgattc gccagccata tatcaagcat actggcttca tcgataatta acagcttccc 2489161 ttcgatcggc tgatcctctg tatgagtaaa gccttcagcg ccgttccagc caagcagcct 2489221 gtgtatcgta actgcaggga gtcccgttga ttcactcatc cgttttgctg ctctccctgt 2489281 cggagcggcc aaaacaatcg gaaaagcttc atccttttta taagctgacg ggtctagtga 2489341 cacaccgtga agctctccgt agagctcgac aatccctctg attaccgtcg tttttcctgt 2489401 tcccgggccg cctgttaaaa gaagcatcgg cgaggaaagg gctttttgaa tcgcttcctt 2489461 ctggctgggg gcatactgaa cgtccatccg ttcttccagt tctcccaacg cgagcaaaaa 2489521 ctctgattcg ggaaactggt tctcatattc ggtttggcta gcgatatgtt tcacacgctt 2489581 tgcaacgttt tgttctgcgt aaaacagcga aggaaaataa cagcggccat cttctatgac 2489641 aatgtcttta ttttctccaa gggcaataat tgcgttagcg gcatccattt ctgtaatgcg 2489701 ctgcccttcc cttgctgact ggtttaacag tgattgagtg tcgatgatca gctgttccgt 2489761 ttctatgtac gtgtgcccct ctgacagaca agtcgtttca agcgtgtaca aaatagcagc 2489821 ttttacccgc tcaggatgat tacccgaaag acccattctg ctgcccagct catccgcttt 2489881 tccaaacccg atgccttcta catccttcac aagctgataa ggattttcct gaatcttttc 2489941 aagcgtctcg gattcatagg cttgatagat tttcatagac agctgcgggc caaagccaaa 2490001 ctgattcaag gaaatcatga tttgctccag tccctgatgc cgctgcaatg cgccagccag 2490061 cgtgtctgct ttcttttttg agagtctggg aacatcataa agcactgaag catcagccaa 2490121 tattttatta atggcgctgt cgcccagctt tttcacaatt tcttcagctg tttttttgcc 2490181 gatcccctcg aataaatcac tcgataaata ttgaatgatg ccttccttag tcgttggaat 2490241 ctcctttttg aaatgctccg cctgaaattg gagcccgaat tttggatggg ttacgatctt 2490301 tccgtaaaac gtgtaggtct cttcttcttg aagcgcaggg aagtagcccg tcacggatac 2490361 ggctttatct tcaatggctt cggaggtctc tgtgactttc actttcagaa ccgtatataa 2490421 attggtgtca ttatgataga tgactgtgtt gactgtccct tttaaatagg gctcttcctc 2490481 cagtttaagc tgatccggat gctgctgcac gagctgtccc tcctcctgtg cctgttatga 2490541 tggatcaatc agttttttag catgaagcgc aagcatatga tctggctgga tatcgattgc 2490601 cttgtccagc atttccagcg ctttttctcg gttttcttta taagcataag tgacaccggc 2490661 attataaaat gcatctgcat gccccgggtc ttgctctgtc acagctgcga attggctgag 2490721 cgcttcgtcc agcatgccct cgttggctaa gcacatcccg aattgaaaac gcgcttccgt 2490781 atcgttttca ttcagttcga ctgctctttg taaatatggc agtgcaagct taggctgttc 2490841 gagcttgaca agtaccgttc cgagcatgta aaacaggtcg ccgttttcca tccccgcacg 2490901 tagcgctttt tcaaacatgt ctttcgcttc tttgtacatt tcttttacaa catagacatt 2490961 tcctgctcca taataagcag tggctgcgct actgtctaat tcaagcgctt tatcataaaa 2491021 cgcaagcgca cgttccagct cgtttacgga tgaaagaagg ttggcaaaat tgatatacgg 2491081 aatcgcgtct tctttatttt cttcaatcgc ttttgtaaat gcctctgccg ctttctcgta 2491141 atcgccttcc tgcatcgcct ctataccgag ttgattataa tccaccgatc atcttccttt 2491201 cattaaaaaa ccccaactca gtgttgaggt ttttcatctt ttatacgtac cacaattttg 2491261 ttccgtcttt gtacacatca tcaattgtcc cgccgccaag gcattcttcg ccgtcataga 2491321 agacaacggc ttgtcccggc gttacagcgc ggacttgttc atcaaagatg acttccgctt 2491381 caccttcgcc agtcatgcgc actgttactt tatgatcctc ttggcggtaa cggaatttag 2491441 ccgtgcagga aatctcttcg cccttcatga tatccgaacg tacccagctg atatttgttg 2491501 ctgtgatttt gtcggaatat aaaagcgggt tatggaaccc ttgatctacg tagaggatgt 2491561 tcttttcaag atctttgcct accgcaaacc acggctcgcc gcttccgccg atgccaaggc 2491621 cgtgacgctg tccgatcgta tagtacatca acccgtcgtg gcggcctttt acttcgccgt 2491681 ccatcgtcat catatcgccc ggctgtgcag ggagatattg gctgagaaac gttttgaagt 2491741 tgcgttcgcc gataaagcag atgcctgtac tgtctttttt cgtcgctgtt gcaagttctg 2491801 cttctttggc aatttcacgc acacggcttt tttgaagttc gccgatcggg aacatgactt 2491861 tgctcagcgt atcttctgtc agctgattca ggaagtacgt ttgatccttg ttttcatcaa 2491921 tgccgcgcag cattctgact tttccgccgc ttctgtctac tcttgcatag tggccagtcg 2491981 ctaaatagtc ggcgccaagt gacaatgcat gctccaaaaa ggccttgaat ttaatttctt 2492041 tgttgcacaa tacatccggg tttggtgttc tgcctgcttt atattcatca aggaagtatt 2492101 gaaatacctt ctcataatat tgcttttcaa agtttacggc ataatacgga attccgattt 2492161 ggttgcagac gcggatcaca tcttcataat cctctgtcgc cgtgcaaaaa ccgttttcgt 2492221 ccgtatcatc ccagtttttc ataaagattc cgattacatc atagccctgt tcttttaaca 2492281 gcagggccgc cacagatgag tctactccgc cggacatgcc gacgacgact cttgtatcct 2492341 ccggccgttt ttccatttca ttcactccaa ttactacgcc gccttattat gtcagccgtt 2492401 tgacaacgtc ggccacatgt ttggcagcag ttttcacttg ctcagccgta ttgccgaggc 2492461 cgaagctgat tcgaatagag gacgtcagcc ggtcactctc ttcgccgaac atagcagtca 2492521 gaacatgtga cggcaggact gaaccggccg tgcacgctga accgctggag acagcgacac 2492581 cagccatatc aagattaacc agcagcgctt ccactgacac accggggaaa taaagattca 2492641 gaacatgcgg cagactatgc tctttgtccc cgttgacctc gaatgccaca cctgcatctc 2492701 taagcgtgtc ggcaaagatt gctttaaacg attgatactt ctcgtttttt tcgtcacgtt 2492761 cttcacttga cagcttgatc gcttctttca gcccgacaat gcctggaaca ttttccgttc 2492821 cggcacggcg ttttctttct tgctctcctc cgaataaaag gggtgaaagc ttcacatctt 2492881 tactagcata taaaaagcct gtcccttttg gcccgttgag cttgtgcccg gaaacagaca 2492941 gaaggtcaat atggctgttt ttcacatcaa ttggcagcaa cccgaatgcc tgaacagcat 2493001 cggtatgaaa ataagctttg tgttccttta acagctcacc gatttcttcg atcggctgca 2493061 ctgttccgac ttcattattt ccatacatca ctgtcacaag gattgtatca tcacgcagtg 2493121 cttctttcac ctgttttgca ctgactcttc cattttggtc aacgtccaga tacgttatgt 2493181 caaatccgtc tccctcaagt ttttcacatg tgtgaagcac ggcgtgatgc tcaatttttg 2493241 ttgtgatgat atgtctgcca agatcttttc ttgcaagtgc ggttcccatg atcgccaagt 2493301 tatcagcttc cgttcccccg cttgtaaaaa tgatctcctg ctctgccgct ccgatttctg 2493361 ctgcgatctg cgctcttgct tcatccaccc attttcgaga ttctctgcca aatgaatgaa 2493421 tactggaggg attaccgaaa ctgccggaga agtgcggtat catttgttcc agcacgcgct 2493481 catccatcgg agacgttgcg gcatgatcta aataaatccg ttccattatg tttacacctc 2493541 tgatctaaat atagaacata taagcttctt gctctccgtc tgtatagctg gcaagatcct 2493601 ctaatgttgt actgtctaaa acctctttta cagcatcccg gatgcgaatc cagagctcac 2493661 gcttggcagg ctcctcatct tccagcactt caacagggct gatcggcccc tcaagcacac 2493721 ggataatatc tcccgcagta atggcatccg gctcactgcc taatacatat ccgccatatg 2493781 cgcctctgat gcttttcact aaaccggcat ttctgagcgg cgataccagc tgctccaaat 2493841 aatgctcgga caaattattc gtctgtgcga tgctttttaa tgaagtcggg ccttcaccgt 2493901 gcttttttgc aagctcgatc ataatggtga gcccgtatct tcccttagtt gatattttca 2493961 acatgaacac ctctgttatt tcatgatttt ccacatttat aatggtaatt tctatatgtt 2494021 tcgtccgttt attatcttat agaccaactg ttattataac ataccttcag cgaattttca 2494081 ttgaggcaga aggaaagggg cctttaccct tttctaatgt acggttttcc gttaccctgt 2494141 aattaagtaa ggagagatga tagatgaagc cattggcata tcggatgcgt ccgacaaaaa 2494201 tagaggatat tatcggccag cagcatctgg tggctgaaga taaaattatt ggcagaatgg 2494261 tccaggcaaa acatttgtca tccatgattt tgtacgggcc gcccggaatt ggaaaaacat 2494321 caatcgcaac agcaatcgcc ggttcaacaa gtattgcttt tcgaaagctg aatgctgtca 2494381 ttaacaataa aaaagatatg gaaatcgtag ctcaggaagc caagatgtcc ggccaagtga 2494441 ttttgattct ggatgaagtc cacaggctgg ataaaggaaa acaggatttt ctattaccct 2494501 atttagaaaa cggaatgatc attttgatcg gagcaacgac ggctaacccg tatcatgcca 2494561 ttaatccggc gatcagaagc cggacccaga tttttgagct tgaaccgtta acacctgaac 2494621 tgattaaaca ggcactggaa cgtgcgctcc atgatgagca tcggggcctt ggcacctatt 2494681 ctgtatccat tgatgatcag gcgatggagc attttgccca cggatgcgga ggagatgtcc 2494741 gctccgcttt aaatgcgctt gagcttgccg tgttgtcaac gaaggagtca gcagacggtg 2494801 aaattcacat tacattagaa accgcggaag aatgcttgca gaaaaaaagc ttttctcacg 2494861 ataaagatgg tgacgcgcat tatgatgtac tgtccgcttt tcaaaaatca atccgcggct 2494921 ctgatgccaa cgctgctctt cactatttgg ctagattaat tgaagccggt gatctggaga 2494981 gcatcgcaag acgattgctt gttatcgcct atgaggatat cggtttagca agcccgcaag 2495041 ccggccctag agtgctgaac gctattcaga ccgctgagcg agtcgggttt cctgaagcgc 2495101 gaatcccgct ggccaacgca gttattgagc tttgcctctc accgaaatca aactctgcca 2495161 ttctggcaat cgatgaggcc ctggcagata tcagagccgg aaaaattggg gatgtcccga 2495221 agcatttaaa agacgcgcat tataaaggag ctcaggaatt aggaagagga atcgactata 2495281 aatacccgca caattacgac aacggttggg tcgaacaaca atacctccct gatcctctga 2495341 aaaataagca atactataag ccgaaacaga ctggaaagtt cgaatctgcc ttaaagcagg 2495401 tgtacgataa attaatgaaa agaaaataaa acaaaaaaac agccttgatc atcaaggctg 2495461 tttttatgca ttatttatcc ttcacacgtt tgatttcaat gtctttcaaa agatccatga 2495521 caacatgtcc gcccataatc aaacctgcaa ctgacggcac aaaagcatta gaggaaggcg 2495581 gcatttttgc tttacgtatt ttcgcttcgt cattccccac ttcttttctg acatcttccc 2495641 gaataacaat cgggctttca tcagagaaaa tcacttgaac gccttttttg ataccctcct 2495701 tgcgtaattt cgtacgaacg accttcgcaa ttggatcagt gtgcgttttt gagatatcag 2495761 cgatttggaa gcgtgtcgga tccgttttat ttgcagcacc catgctggag atgagcggaa 2495821 tatcccgttt tagacattct ttcattaaat gaattttata acaaatggtg tctgacgcat 2495881 caatgacata gtcaagacca tagtcaaaaa actgctcata cgtttcctcc gtatagaaca 2495941 tttttaacgc gatcacttca cactccgggt taatgtctgc gatccgcgcc ttcattaaat 2496001 caactttcgg ctgtccgaca gttgaaagca gcgcgtgaag ctgacgattt acatttgtaa 2496061 tgtcgacatc atctttgtcg acaagcagaa tgcggccgac gcctgaccgc gcgagagctt 2496121 ccgccgcgaa cgacccgact cccccgactc caagcacagc aactgtgctg tttttcagcg 2496181 tttcaaggcc ttcttttccg atagctaatt cattgcgtga aaactggtgt aacaagaacc 2496241 tcactccaca ttcgtattct ggtttcatct ataaaatggc tgatccatga gcagccgttt 2496301 tttctgcgca caaaaaataa agtcccaata gtgccgttgc agctttcctt tgttttgaac 2496361 ccgctctcag caggtgggtg ccctctttta aatcttgtaa gtcctcttta ccgaatgaaa 2496421 agaggcatgt acgccattta aaaatgcggg ctcccaaatc aaaaaaatgt tcggtcaaaa 2496481 ctaggtgtac aactaacaca tcaggacttt atttaacttg tcaaaatcat atcacagacg 2496541 attttgattt tcaagaatcg aactgcaaat tcagttctta acttttttct tgatagaaag 2496601 atgaagctcg tcaagctggg cgtcgcttac ttcgcctggc gcttctgtca tcaggcagct 2496661 tgcacttgcc gttttcggga atgcaatcgt atctctcagg ttcgtacgtc cagcgagaag 2496721 cataacgaga cggtctaagc cgagtgcgat tccgccgtgc ggaggagcgc cgtattcaaa 2496781 tgcttccagc aggaatccga actgttcagc cgcttcttct ggtgagaagc cgagaagcgc 2496841 aaacattttt tcctgaatat ccttttcgaa aatacggatt gaaccgccgc caagctcata 2496901 gccgtttaag acgaggtcat aagcttgcgc tttcatgtct tcaggcgctg tttcaatcag 2496961 ctcaaggtct tctcggacag gcattgtgaa cggatggtgc gctgcgtaaa aacggccttc 2497021 ttccggatca tgctctaata gcggccagtc gatgacccat aagaaattga acaatttttc 2497081 gtcaatcagt ccgcgttctt tcccaagctt taagcgcagg gcgccgagtg atgcggccac 2497141 aacttcgaat tgatccgctc cgaacagcag caaatcacct tcagcagcat caagtgcttc 2497201 aatcagctta gactgctttt cttcatcaaa gaatttagcg atcgggcctt tcactccgtc 2497261 tgcctcaacc ttcacccagg caagcccttt tgccccgtag tttgcagcaa aagcgccaag 2497321 agcgtcgatg tcttttctgg agtaatcgcc ggcaccgcct tttacattga tggctttgac 2497381 cacgccgccg tttgctacag ctgatgagaa cactttaaat tccgtatcct ttacaatgtc 2497441 agacacatcc gtcaaaagca tgtcaaaacg cgtatccggt ttatcagacc cgtacttgtt 2497501 cattgcttcg tcatacgtca ttcgaggaag aggaagctga agttcctcac cttttgtttc 2497561 acgcataacc tttgccatca tctcctcagc caatgacata atgtcttcct ggctcataaa 2497621 ggacatttca atatcaattt gcgtaaactc aggctgacgg tccgcacgca agtcttcatc 2497681 gcggaaacag cgggcaattt gataatatcg ttcaatgcct gataccatca gaagctgttt 2497741 aaatagctgc ggagactgcg gcagcgcgta gaactcacct tcgtgcacac ggctcggcac 2497801 caagtagtca cgtgcgcctt caggcgtgct tcctgttaaa atcggcgttt caatatcaag 2497861 aaacccattt tcatctaaaa agctgcgaac agctttcgtc acgttatggc gcagctgcat 2497921 cgtctggaac atagccggtc tgcgcaaatc taagtaacgg tgttttaaac gaacgtcctc 2497981 tgacacttct tcagcttgat cagaaatcgc aaatggaggt gtctttgcag catttaatac 2498041 gttcactcca tcagcatgta tttcgatcgc gcctgttttc aaattcggat taactgttcc 2498101 ctcttcacgc gccaccactt ttccttgaat atcaagcacg tattcatttc tgatgccttc 2498161 cgcaatagca agcgcttctt ttgacacatc agggttaaaa acgacttgaa caatgcccgt 2498221 acggtcacgc aagtcaataa aaatcaatcc gccgaggtct cgtctttttt ggacccagcc 2498281 tttcagcgtt acagattcgc caattgcttt ttcagttata tcaccgcaat aatatgttct 2498341 tccaaacaat gcgtttcact ccttatccct tttggtttgc cttcatcaca tgtataaatt 2498401 catcaagtgc cacttcaatc tgttcgcccg tctgtgcatc ctttacattg attttgtttt 2498461 gggcaagctc atcttcaccc aaaatcgcaa taaatctggc ctttaagcga tcagctgttt 2498521 taaactggcc tttcattttc ttattttcat aatcgatttc actggaaatg cctgcttctc 2498581 tcagtttgta caccaatgaa acagaataat cctttgcttt ttcgccgagt gtgacgatat 2498641 agcagtcgat tcccttatca acaggcagct ctcttttttc agcatcaatt gcggcaagca 2498701 agcgttcgat gctcatcgca aatccgatgc ccggtgcttc aggtccgccg atctgttcga 2498761 caagcccgtc gtagcgtccg ccgccggcaa gtgtcgtaat cgcgccaaag ccctccgcat 2498821 tgctcataat ttcaaatgcg gtgtggttgt aataatccag ccctctcaca aggttcggat 2498881 cgatttcata cgaaatgcca agatcattta agtattgttt cactttttca aaataagcgg 2498941 ctgattcttc atttaaatat gtcaaaatcg aaggtgccga tttcatcagc tcatgatcac 2499001 ggtctttttt gcagtccaaa attctaagcg ggttcgtgtg cagccgggac tggcagtctg 2499061 aacaaaattc ttcgatgcga ggctcgaagt gtttcacgag cgcttctctg tagcttttgc 2499121 ggctatcttg atcgccgaga ctgtttatga caagcttaac gttttctaaa cctgcttttt 2499181 cataaatact catcgcaagc gccattactt cagcgtcgat tgcagggtct ttcgaaccaa 2499241 tcgcttcaat tccaaactga taaaactggc ggtaacggcc cgtctgagga cgttcataac 2499301 ggaacatcgg cccgacataa taaagctttg tcggctgtac aggatttgcg aacagcttgt 2499361 tttcattaaa agcgcgaacc gcagcagctg ttccctccgg acgaagcgtc aggcttctgc 2499421 ctttgcggtc ctcgaaggta tacatttctt tttgtacgat atccgttgat tctccgacgc 2499481 ctctggcaaa cagttctgta tgctcaaaaa tcggtgtgcg gatttcttta tattgataag 2499541 tgcggcaagt gtctctcata atttgttcaa caaactgcca gcgatctgat tctccaggca 2499601 gaatatcctg tgttcctctc ggaatgttat atcccatagg tagacctcct tatgtattcc 2499661 ttataaaata tccaatgatc gttaatgatg aaaatgaaaa aaactcccgc ccctactata 2499721 catgatagta gggacgagag ttatacccgt ggtgccaccc tagttggaat acgttcatat 2499781 tcccgctcga tcctttaacg caggttcacg ttcactgcct aatggcgtta ttcacgcgtt 2499841 cagcaggaaa cctccggagt gttgtttcga gaaagacgca atgggatccg ctttcagcct 2499901 ggggcgggtt cctctctaat catgcaatct gacctactct tctccattat tggttcaaat 2499961 ctttcatcat ttgctatgta ctcaatttct attataataa tgggattggg gttctctgtc 2500021 aagctttatt ccggttgttt ttcctcagcg ctgcttcttt ggacataaga ccaaattcag 2500081 atgctgtttc cgtaagataa ccagtcgtat cgggatctgc gtgatcgctg taatgcagat 2500141 tcgcttcacc gtcgtgaaat gcacgtccca tttttggatg atatttcatg atttgcacac 2500201 ctttttgatt gtatttacgc ttagtataaa caaatcattt tatttttatt taaaaatcag 2500261 aaaggacttt acgatattaa acaagaatgc ttttttaatg atcatcagaa aggaggacac 2500321 aatgaacaag aaatactttg tccttattgt atgtattatt ttcacctcag cgctattccc 2500381 gaccttttca tccgttacag ctgctcaagg agaagcggtc atcgcaacag atgaaatgaa 2500441 cgtcagaagc ggcccagggc ttagctacgg cattacagcg gaagtaaaaa agggagaacg 2500501 ctatccaatt ttaaaggaag atggagactg ggtgcagata cagcttggtt ctggagaaaa 2500561 gggctgggta gtctcctggc ttattacaaa ggaagaccag gccagcacaa gctcctcagg 2500621 aagcagtgac actgtgacat caacagaccc cgatctgcgg atgagaagcg gcccgggcac 2500681 ttcctacgaa gtcatcggca aattcccgca aggcagccaa gcatctgtca ttgataaaga 2500741 ttcgggctgg atcaagatat cctatcacag tgccaccgga tgggtatcat ctgaatatgt 2500801 cacatcagga ggcagcagtt cagcgtctga tgagagtgac caaaccgagg attccggtgc 2500861 gtcaacgacg ggcacagtcg gtgtttcttc gctaaatgta agagcctccg cctcacatga 2500921 cgcggcaatt ataacaaaac ttgatcgcgg aacgaaactg acggttctca acgagaaaaa 2500981 tggctgggct cacattgagg tgaacgggct aaaaggctgg gttgcaagcc attacctttt 2501041 gactagttct gttccagctg atgattcagc aaatgccggc agttcatcct ccgctaaaaa 2501101 agcctatatc atgtacggag gaacgaatct aagaagtgat gcgtcaacat cagcttcgat 2501161 cgttgagcgc gctgccaaag gagattcata caccattacc ggttcaaagg gaagctggta 2501221 tgaaataaag cttgataacg ggcagactgc ttatgtagcc aattgggtgg tccaaacgtc 2501281 taaaagcgca gaagaagcag gtgaaccgcc agtctctgat tccccgtctg gaaacggctc 2501341 tctaaacaat aaaacgatta ttgttgaccc gggacatgga ggaaaagaca gcggaacgat 2501401 cgggtattcg gggaaattcg agaaaaacct gacgatcaaa acggcaaaac tgctcgccag 2501461 caaacttaga tcggctggag cggatgtata tgtgacacgc caggatgata cctttgtcag 2501521 cctgcagtca cgggtctcta cctctcacta ccgtaacgct gacgccttta tcagcattca 2501581 ttatgacagc tatgcggata cctctacaag aggcagtaca gcatattact acagtcctgc 2501641 caaagatcag gaactcgcat cagatgtcca ctcagaagtg gtgaagcgtt cttccattcc 2501701 agaccgcggc gtattattcg gagattatta tgtgctccgg gaaaacagac agcccgctat 2501761 gctgtacgag ctgggatatg taagccatcc gcaggaagaa gccattgtac atagcaattc 2501821 ataccaagaa aaagtaacag atgggatcga aagcggatta gagaaatact tccaataaaa 2501881 aaagctgcct tttggcagct ttttttattt tgaatccata atgagcgtga ccggtccgga 2501941 gtttgtaagc tgaacatcca tcattgctcc aaacgttccg gtctccactt tgattccttt 2502001 ttcacgaagc aggtcattcc atttttcata aagacctaaa gctttatcag gtttggccgc 2502061 gttcatgtag ttcggccggc gccctttttt cgtatctcca taaagcgtaa actgtgagac 2502121 ggataaaatc tctcctccta tatctacaag agacagattc attttccctt cactgtcatc 2502181 gaaaatacgg agattgacaa ctttatcggc taaataagct gcatcatctt ctgtatcatc 2502241 gtgagtgatg ccgaccagca ccataaggcc ttgtccaatt tggccgacga cctcttcgtc 2502301 cactgtaacg cttgcttctg ttactcgctg aacaactaat ctcttttcta acccctttag 2502361 ttcatgacgc ggcgcacaga atagatatct ctaatctgtt taatacgctc gacgacttta 2502421 tgcaagtgat tgatattctg gataaaaatc gccatatgga tggttgccac tttattgcga 2502481 tccgatttgc cagagacaga tgaaatattg gttttcgttt cattcactgc ctggagtacc 2502541 tcgttcagca atccgcggcg gtcataccca agaatctcta tctcaacatt gtattccttg 2502601 cgcttttgaa cttgtgactc atgttcccac tctaccggga tcagccgctc ttgggcttca 2502661 ttcgttttga cattcggaca gtcttcgcga tggaccgaaa cccctctgcc ttttgtgata 2502721 aagccgacaa tatcatcacc tggcacagga ttgcagcatt ttgataaacg gacaaggagg 2502781 ttgtcaatgc ccttgacacg aacgccagct tcccgttttc ttccttgcgg gtatggctta 2502841 ggttccccag tgacttcctg aacgatcttt tcctgttctt cctggtcgcg ctgctttctc 2502901 tctttttctg ttaggcggtt cgccacctgc agagctgtga tgccgttgta accgaccgcc 2502961 gcgtacatat cctcttcatt tgagaaatta aatttgtcag caaccttttg aatattctcc 2503021 ggcgttaaaa catccttcaa ttcaaaatcc aagtttttaa tttctttttc gaccagctca 2503081 cggccttttt cgacattttc ttcacgccgc tgtttcttaa agaattgacg gattttatgc 2503141 ttcgcttggg atgtttgggc aagcttcacc caatcctggc tcggaccgta ggaatgctta 2503201 gaggtgagaa tttcaacgat atcacctgtc cgaagcttat ggtcaagcgt aaccattttt 2503261 ccgtttactt tggcaccgat tgttttattg ccgatttcag agtgaatccg gtaagaaaag 2503321 tcaatcggaa cagaaccgga cggaagctcg attacatctc cttttggcgt aaagacatac 2503381 accatgtcag agaacaaatc aattttgagc gattccataa attcttctgc atctgtcgat 2503441 tcattttgaa attctaaaat ttcacggaac caagaaagct ttttctcaaa ggttgcacct 2503501 tcattggctg ctttcccttc tttataagcc cagtgagccg caaccccgta ttccgctatt 2503561 tcatgcattt caaaggtgcg gatctgcact tcaagcggat cgcctttagg cccaataacc 2503621 gttgtatgaa gcgattgata catattcggc ttcggcattg cgatataatc tttgaatctg 2503681 cctggcatcg gtttccagca tgtgtgaatg atgccaagca ccgcgtagca gtcctttatg 2503741 ctattcacaa gaatacggac agccaacaaa tcgtaaattt cattgaattg cttattttgc 2503801 agcaccattt ttcgataaat gctgtaaata tgtttcgggc gtcccgagaa gtcagccttg 2503861 atatttactt cttcgacacg tttcttcact tcattgacaa cctcatcgac ataaagctct 2503921 cgttctgcac gtttcttctt catgaggttg acaattctgt aatattgctg agggttcaaa 2503981 taacggagcg ccgtatcttc caattcccac ttaatttttg aaatcccgag acgatgcgcc 2504041 aaaggagcaa aaatttccag cgtttcattg gagattctcc gctgtttttc ctgaggcaga 2504101 tgtttcagtg tccgcatatt gtgaagacga tccgccagct tgatcaatat gaccctgata 2504161 tcttgagcca tagcgacaaa cattttgcga tgattttccg cctgctgttc ctcttgagat 2504221 ttatatttaa ttttgccgag tttcgttacg ccgtctacaa gcattgccac ttcttcggaa 2504281 aatgcttctt tcaggtcatc gagcgtcaca tctgtatctt ccacgacatc gtgcaaaaat 2504341 ccgcccgcga ttgtggaagg gtccatttca agatcaacga gtatccccgc aacctgaatc 2504401 ggatgaataa tatatggctc gcccgatttg cggtattgct cgcgatgagc atcttcagcg 2504461 tacagatatg ctttttcgac aaatgcgata tgctcatcag atagatagct gcgtgcttta 2504521 tctataactt gctcggcagt caatacttgt tcgttcgcca tggaatcacc ttttttaaaa 2504581 tgtaaactgt attgtagttt attatcaaga aaaaaacgaa agatgtaaag agcagaagtt 2504641 caaatagcca aatattatat aaaataaatg caaaacaata ggaaaaaagc accctgacat 2504701 ggagtgcttt ttcgttatgc ggttatcctt agtatttcat caatgttaag atgtcgtaat 2504761 cttcgagctt atttctgccg tcaaggtaag aaagctcgat taagaaagcg ataccagcaa 2504821 caacgccgcc aagttcttca acaagtttga ttgtcgcttc aattgtgccg cctgtcgcaa 2504881 gcaggtcatc tgtaataagc acacgctgac caggcttaat cgcatctttg tggatcgtta 2504941 atacgtcttt tccgtattcc aagccataat ccactttgat tacttcacga ggcaacttgc 2505001 cttctttgcg gaccggcgca aaacctacgc caagcgcgta agcaacggga cagccgataa 2505061 taaagccgcg cgcttcaggg ccaacgacca aatcaatttg cttttctttc gcatattcaa 2505121 caatttgatc tgtggcatag cggtatacat cgcctttatc catcagtgtc gtaatatctt 2505181 taaattgcac gccctctttc gggtaatccg gtacaattgt tacgtattgt tttaaatcca 2505241 tctgttttat gtcctcctcg tactttcata agcctctgaa tcttgtttca tcagcttatt 2505301 cagccattcc ttcagctctt cagcagaaga ataattcagc ttttgatcca gttccatcag 2505361 ctgctgtttc gcctgatatg tttgtgagtc tgttaagtcg cgtttctttg ctccgctcac 2505421 aacagacagc acaccattct ctattttaac aaaaccgaga tcaaaaaaca cctttgtcat 2505481 gaaattgatt gtttcaacgg accagccttt atgttttgca agctctgaac cgtgtttttt 2505541 cacgtcaaaa gcgcctcttt tcagcaagaa cgcataatac catttaaagt ggtctcttgc 2505601 gggaaaagtt gataaaaagt ggtcctcatg attgagaaaa ataaaatata tccgctcggg 2505661 cgcctttcct tccagcaaac gtgcgagcat gtccagcgaa ggcggcggat ccagtaatac 2505721 aatatatgca ccatcgaggt caaacgcctt tgcttgatct ttagaactga tgacgtgcac 2505781 ttctcggcga aggtcttcag tttgaagtaa tgttgttgag tcttctttga aagagacaat 2505841 ggcccgttta gcagatggaa gggcggaaac tgtgtcttcc cacgtccgtt ttccccttaa 2505901 atcaaacagc tgccattcag aaacagcggc atcctttatc ataagctgcg gcttttttcg 2505961 attgttccat tcgttgattg acatctcacc gacaatggaa attcttgaac ccggtacgat 2506021 gccttcttga agctcgcctt tattaaaacc gacgcaatca agctgggacg actcgtttct 2506081 gatcgtcatt ttgacatgag ttttatttgc ccctatcttg cggacatctt ccagtactgc 2506141 attttctacg agaacgtgcg gtttcgggtt cagcatgcca aaaggagaca gcatgttcat 2506201 ttctgcgatg ctttcaactg taatgtcttc gacgccgcag acaaggtcga cttcctgtac 2506261 gggaataaaa tcctcttccg taagcgtatt gtccgctatt tcattcagcc tgcttcgcaa 2506321 atccggcaca tcttcggctt tcagcgtcat ccccgcagcc attggatggc cgccgaaatg 2506381 aggaagaata tctctgcatt cagaaaggct ctcaaataaa ttaaatcctc tgatgcttcg 2506441 ggccgaacct ttagcgattc ccttttcttc atcaatacca agaacaatgg ccggtcggta 2506501 gaaacggtcc acaagctttg aagccacaat cccgacgact cccgggttcc atccggcttt 2506561 ggccacgaca attgcagttt gatcgagccc ttgctgttca accatttcaa tcgcttcatc 2506621 cgtcattttg ctgaccattt tttggcgctc tttgttcagc tggtcaattt ctgcggcaag 2506681 ctcttccgct tcaaacgaat cctctgacat aagcaaatga acagcgggat ccgcctgttc 2506741 gattcttccg acggcattca gccttggtgc gagctgaaat ccgactgttt cttcgttcgc 2506801 ttctccgatg tctccgcctg acagcttaat cagctctttt aagccgagcc gatttgtccg 2506861 tcgaagcctt tcaagtccta gtgttgctat taatctgttt tcgtcatgca gcgggactag 2506921 atcggcaatg gtgccgatag ccgccaggtc aagcagttca tcaggaagtt cacccaataa 2506981 agcgtgggca agcttaaacg cgactccaac cccggcaagc tctttaaacg ggtaagtgca 2507041 gccaggctgc ttcgggtgga cgatcgcacg gacatccgga agctccggtc ccggttcatg 2507101 atgatcggta atgatgacat ccagtccgag ttcctttgcc accttcgctt catgcacagc 2507161 ggcaattcct gtatcaaccg taatgatcaa agagaagccc cgttctttaa tcgaacgaaa 2507221 cgcctgttca ttaggtccat atccttcttt aaaacggtca ggtatataaa aatcaacttg 2507281 agccgacagt ttttgcagcg tgtgaagcat cactgacgta cttgtaaccc catcggcgtc 2507341 ataatcgcca tatatcataa tcttttcttg ttgtgaaatc gcctgtttta ttcgatctgc 2507401 cgcttctttc atgcctttca tttcaaaagg atcataaaaa tcggcatcct ttgtatgtaa 2507461 aaacagccta gcgctttctg ccgtatcaaa gcctcttttt acaagcaggg acgcaacaag 2507521 aggtgttata tgcaattgtt ctgtgagtga tttgacctta tcctgatctg gtcgctggat 2507581 ttcccatcgc atttttgacg ctaacataaa ttcacccctc aaccacccta ttatactaga 2507641 gcaggctgag gggtttcaaa taatattcga aaactagtct tttttctcaa tcatggctga 2507701 tgcatcctgt gtgtcagtct gatcagcaag atgagtatcc tcttgtttat gtattgctgt 2507761 tctattttct ttccgcaagg tttttatttc ccgcttcaat ttcattacct gaaaaatgcc 2507821 gacagaaaat acgatcagtg ctcccattaa aactgagccc aaaataacaa gaatgagcgg 2507881 ccattctgat cttccaaaca ggtaatcaac ttctacggat cgaacattaa tgactgcgaa 2507941 aatagcgaca attaaggtga aaataagtgc gaaaataatg gtccattgtt tattcattct 2508001 cttttccccc aaacttctta ttgaggtaac tttcccaatc aagactggtt ttaaacatgg 2508061 cttaacacta ggttaagctc cctttgctgt taatttttcc cggatcagcc tcttcagtcc 2508121 ggttccctca ccggaaatca caagtgtatc gccttcgtca atgactgttt cagagctcgg 2508181 attcagttgt ttatcctgat tctttttaac aattgcaatg accgtcacat gatattcctg 2508241 acccacattc aaatcaccaa tcgtctgatg aatggcaggc gctcccgcct ctgctttaca 2508301 ccactctata atcaaatcat caagggctga ctcgacctgt tctaatgctt tcggtttata 2508361 tgccattccg ccaagaattg cagacatttg ccttgcttca gcgtcatcaa actgcacgga 2508421 ggcaacacat tcctcatggt cgttttcgtc aaaatagtaa agctctctcc gtccgtcatg 2508481 atgaatgata attgaaattt tatcacggtt tctagtaatc atttcaactt tttgtcctat 2508541 gcccggcagc tctgattcgc gaaccctcat atataaaccc tcctacatat ctgaaaacca 2508601 gccataaaca cttttaacac catatatatg tttaaatgta agcgtatgtc attatagcaa 2508661 atgtctattt taagttcaat gaaacttcaa aaaacaggct gccctgcaga ggacagcctg 2508721 atatttttta ttgcgccgaa tcttttttca gttctcttcc tttccatgca agccaaattt 2508781 gtgcggcaat gtatagagaa gaataaacgc ctgttaacag cccgaccaat aaagcaattg 2508841 agaagttagt aatagaagat gctccaaaga tcagcaatgt cacaacaaca atcacaacgg 2508901 ttaatacagt gttaattgaa cgtgtaaagg tttgctgcag gctcaggttt acaatatggt 2508961 tcagatcggc aaaggttttc ggcttacgct ttttcatatg ctcgcggacc ctgtcaaatg 2509021 taacgattgt atcgttaatg gaatacccga ttatcgtcaa gatggccgcg atgaatgtaa 2509081 catctacctc aagccttgta atactgaaga acgtgacgat aaagaatgcg tcatatagca 2509141 atgaggcgat ggcagcaatc gccattttgt attcgaatcg gattgaaacg taaataatga 2509201 tgccaataga agctatagca actgcgtaca gcgcatttct cgccagctcc ttaccgactg 2509261 tcggtgaaac tgtgctgaca tttggatcag atccgtattt gtctttaaaa tacgttttta 2509321 cttttgcaat ggtttcttta tctggcaccc cgacaaaacg ggcaacaccg atattgctct 2509381 tttcgcctga cagaactaca gtatcagggt ccatacccag agattcaaaa tccttctcaa 2509441 cttgctctgt cgtcagctta tggtcgcttt gcacttcaat ccgtgcaccg cttgcaaagt 2509501 caatgccaag attcagcctg aacacaagca ggataataat cccggcaacc gtgaccgcac 2509561 tggagaaaat aaagaagtat ttgcgtttgc tcgtgaaatc ccatttttgg aatggcgtat 2509621 gcggctctgt attttcatcc gtatcctgaa tatccatgat atgtttctta ttgacaccaa 2509681 accagccttt tttccgatca agccatctgc tttccacaag gagagcgagg agaaatctcg 2509741 ataagaaaac ggcagtgata aagcttgtca aaatcgatag gatcagcatt gtcgcaaacc 2509801 ctttaacaga gcttgtccca aagataaaga gcacaaccgc tgcaataatg gttgtaatat 2509861 tcgcgtcaaa aatcgtcgca aatgaccgtc tgtttcctga acggaaggca gagcggactg 2509921 actttcctag cttgagctct tctttaatcc gctcataggt aataatgttg gcgtcaacag 2509981 ccatcccgac acctaaaatg agagcggcaa ttcccggaag cgtgagtacg gcattcatcc 2510041 agtcaaagat ctggagtgta atgtagatat aaacagacag cgtaatcacc gcgattaatc 2510101 ccggcagacg gtaatagaaa agcataaata agaaaataat tgcgataccg acaataccgg 2510161 caaacaccgt atcatggaga gcctgctggc cgaattgcgc gcctactgat gtcgaatact 2510221 tttcagtcag tttcacagga agtgcgcctg cgtttaaaat gctggctaaa tctttcgctt 2510281 cttgagctgt gaaatgacct tcaattttta catcagttgt atttagttcc tgacttacat 2510341 ttggagcgga tacaaattta ggatgctctt tttgaacttc tttcttaaag gaatcacctt 2510401 tatcataatc caaccaaatg acaagctggt tgtttggcgc cattttcatg accttcttgg 2510461 tcacttcacc aaatttatca gcgtctttca gcttaatcgt gacaattggc tcatttgttg 2510521 tgctatcata agtttgttta gcgccgtttt cgactagatc agcaccgttt aacagttcct 2510581 tatcatttgc atctctgaaa gaaagctgcg cttcagtcgc caaaatttca cgcgctctgt 2510641 tttggtttgt cacgccagcg agctgaacgc gaatccggtt attcccttca atttggatgt 2510701 tcggttcgct gacaccgaga acattggccc ggcggttcag tgcctctact gtgctgacca 2510761 gaacgtcttt tgtgattttg tcaccttttt ttacaggctg tacatcatac agcacctcaa 2510821 atccgccttg caaatccaat cctaacgtaa tattgttagc ggcaggcttc gtaaagtagc 2510881 ccaagcccgt gccgatcaat agaacgaaaa ggaaaaacgc aatcaagcgt ccttttttca 2510941 ttatgtatat cctcccttaa acctgtgcga atcaacctgc tatctcagca gttcttccaa 2511001 tgcttcctgg ccctcttcac tgcccagcca attagacgtt ttaaatgact caacggttgc 2511061 atagttcata aattcgccaa ttttcactga taaaatatca ctcgccagtt cataaatgct 2511121 cagttccgtt ttctttttcc acttcttatc tgttaagtat gaccacaaac tttcgagttc 2511181 aacatcatca tacccgagaa tcttaaactc ttccagtttg ctgtaaagaa acggcctgac 2511241 gtggtcttta tatagatcgg ctggatgctt ctccacgaat tccacgctcc ttttttattg 2511301 tttttcaaga agacttgtca tgcttggacg acatatacgc atatctttat tgtatatgat 2511361 tccaggtagt ttgagaaggc agggggtaaa aatggcgaaa cagacgtttt taaagggcac 2511421 tcttatcctt atcgcagcag gaatggttac aagaatgctc gggtttgtca accgggtggt 2511481 tatcgcccgt tttatcggtg aagaaggagt cgggctttac atgatggcag cgcctacttt 2511541 cttcttggcc actacattaa ctcaattcgg tctgccggtc gcgatcagca agctagtcgc 2511601 tgaagccagt gcgcgcggag atcatcaaaa aacgaaaaat attttagtca tgtctctgac 2511661 cattacggga gtgctcagcc tcatctttac accgctgttt ctgtttttcg cccctgttat 2511721 ggctgaaacg atgctgacag ataagcgaac actgtatccg ctcttggcca ttacgcctgt 2511781 tgtgccgatt attgctatat cgagtgtgct gaggggatac tttcaaggaa aacagaatat 2511841 gaacccgctt gctatgtcac aagtccttga acaggttgtc cgcatttcac tcgtggctgt 2511901 ctgcacaacg atttttctcc cttacggaat tgaatatgct gcagcggggg caatgctatc 2511961 ctcagtggca ggggagctgg catcacttct ttatttattc gtttgcttta agtataaaaa 2512021 gacaattaaa atcagaaagc attttttaca gtcaattaaa aacggaaaac aaacctttac 2512081 ccaattaatg agcgtgtccc ttccaacaac cgggagccgc tttatcggaa acctctcttg 2512141 gtttttcgag ccaatcgtcg tcgctcaaag ccttgccatc gccggtgtgg caacagttgc 2512201 cgcaacaaag caatacgggg aactaaccgg ctttgccatg acgctgctga ctctgcccag 2512261 ctttattaca tattctttgt cgaccgcgct tgttcctgcg atcagtgaag gaatggagca 2512321 gaaaaaattg caggtggtgg aataccgctt agaacaggcg atgcgtctct gtctgctcag 2512381 cggaggcatt tcagttgtta ttttatttgt atttgcggat gagctgatga gagtgatgta 2512441 cggttcctca ggcgcagctg tatttataaa agtgatggcc ccgttttttc tgctttatta 2512501 tttccaaggc ccgcttcaag ctgtgctgca ggcgcttaat ttggcaggag ctgcgatgat 2512561 gaacagctta atcggagcgc ttgtcaaaac aggccttatt tttgtccttg ccacaaggcc 2512621 ttctcttggc attatgggcg cggcattagc cattgtgaca ggcatggtgc tcgtcacgct 2512681 attgcacgca gcaaccgtaa gcaaagtgct gccgatcagc atcaaaatca aggagtacgc 2512741 gctcagcttc gctgttattg taatttgcgg attcatcagc tccgccatca aacaatatat 2512801 aagctttgga gcatctgagg ctgtcaatct agccggatgg attgcggcga gcgccgccat 2512861 ttatatgatc ctcctgctcg ttttccgttt aattaaaaaa gatgagcttc gccgcattcc 2512921 cattatcgga cggttgatca tccgataatg gtcacgtgcg gtgcccatct ttttcatcaa 2512981 tatatatttc tccgtctgta aacgagcaaa atgaaatatc tgaagggttt gtgtatccgt 2513041 gtttttgcaa actttcaagc agccattttc tatctttact gattctggac aggttttctg 2513101 tttgaatgaa gccgtctata atgagcggca tttcgagctg ccgatgctct ccgctgtttt 2513161 ctttcttaac aatagtcagt ttgcccgacg gctctaaaat agcaaatgat acgtcagcta 2513221 ctctgtcgat gctattttct ctgagctgaa ccattaaatc atcaaaatta taacgctgtg 2513281 atttcatggc ttcttcgtca atttttccat atttgataat tatggtcggc ttaccgtcaa 2513341 gaagctggcg gacttttcgg ttttttaaag aaaagtatgc caaagtcact tgaatgatca 2513401 ttaatacaag cattggcaaa atggtatgaa atagatgatc gtctacgttt tctatggcta 2513461 aaacggcaat ttcagccatc atgataaaga caacgagatc taaaatacta agctctccga 2513521 tctcccgttt gcccatgaaa cgaaaaatga ccaatatcac aaaatacaat acgactgtgc 2513581 gaaacgcaat agtgagaagc tcttccatta tgcacctcca actcattata ggttgcaaca 2513641 aaatgatcaa tttatgtaag aaaaaccgat tgcatttcac aaagctttta cgtctaattc 2513701 atgggataag ggaatacatt tttacaaaga cgagccatca gcatgtctga cggttttgaa 2513761 caaaaagaac agaagccttt taatacaggc agagaggaga caatcatgga ggaaacgaaa 2513821 caagttggaa aaggcattct ttacggctta atcgccatat tttcagccat gctcctgaca 2513881 agtttagcgg tttcactttt attgaccgca acctcgctgg aagaatcatc atttaactgg 2513941 ctgatcaccg ctatctcatt tctctcttta tttatcggcg ggttcatttc aggcgggaaa 2514001 ggcaaggaaa gaggctggat gattggcgca ttgaccgcct taagtttttc tctgattatc 2514061 ttattgtttc agtatttagg attcggaaag acatttacag cagaacagct gatcttccat 2514121 ctgggatttt taggggtgtg catgctgggc gggattttcg gcgtgaacat gaggggaaac 2514181 aggtcttcca cataaaaaag agcgggctca cttgcccgct cttttttgtt tgctatgtat 2514241 agctcctgct gttattcagc agcagaaact tctctgatcg cgcggcggtc gaacgtaaga 2514301 cgtgtgttat caccagtctt aattacgact ttgctttcgt cgatagagtc aacagtaccg 2514361 tgcaatcccc cgattgtcac tactgaatcg ccttttttca gttcctcttg catttggcgt 2514421 acagcctttt gctgcttttg ctgaggacga atcagcaaga agtaaaggac cgcaaacatt 2514481 aaaataatag gaaccaatgt acctaaagtg ccagtcatca ttttcacccc tttctgtaag 2514541 cctgttatgt ttatttagaa gcttttcgca tttggcttgt tatagccgta acgctcaaag 2514601 aactcttctc tgaaatcacc cagacgatcc tcgcgaatag cctgtcttac ctgctccatt 2514661 aagtgtaaca gaaaatgaag gttatggtaa gttgttaatc gaaggccgaa tgtttcattg 2514721 cagcgaatca agtgcctaat gtacgcgcga gtgtagtttt tacatgtata gcaatcacac 2514781 tcttcatcaa tcggacggaa gtctctttca aatttcgcat ttttcatatt gagtcgtcct 2514841 tcagcagtaa acactgtgcc gtttcttgca atccgtgtag gcagcacaca gtcaaacata 2514901 tcgaccccgc ggatcgctcc gtcgatcagt gcgtccggag aacctactcc catcagatat 2514961 ctcggtttat ccttcggcaa gagcggtgtt gtgaattcga gtacacggtt catgacatcc 2515021 ttcggttcac ctacagacaa tccgcctata gcatatcccg gaaaatcaag cgaaatcaag 2515081 tccttcgcac tttgtgtccg cagatcttca tattctccgc cttgtacaat accaaacagc 2515141 ccttgttcat cctgacgatt gtgggcattc aggcagcgtt ccgcccagcg gcttgtccgt 2515201 tcaactgacc tcttcatgta gtcgtactcc gccgggtatg gcgggcattc gtcaaacgcc 2515261 atcataatat cagagccgag tgcgttttgg atctccatcg ctttttccgg agataaaaac 2515321 agcttgtctc catttagatg attgcggaaa tggacaccct cttcctctat attacgaaac 2515381 ttgcttaaag aaaagacctg aaaaccgcct gaatctgtta aaattgcgcg gtcccagttc 2515441 ataaatttat ggagcccgcc cgcttctttg acaatgtctt ggcccggacg aagccataga 2515501 tgataagtgt tgctcaaaat gatgcctgca tccattgctt tcagctcttc aggcgacatt 2515561 gttttgactg tcgccagtgt gccgaccggc ataaaaaccg gcgtttcgaa ggagccgtga 2515621 ggcgtatgca ctttgcccag ccgcgctcct gtttgtttgc attcttttat aaattcatag 2515681 cgtattggtt gttcagccac ttttgatgag gcctcctgtt ctcaaattat ataatcagca 2515741 tcgcgtctcc gaagctgaag aaacggtatt cctcttccac tgcatggtta taggcacgca 2515801 gaatgttttc tcttccagca agcgcgctga ccagcataat caatgacgat ttcggcaaat 2515861 ggaagtttgt aatcattccg tcaatggctt taaattcata gcccggataa ataaaaatag 2515921 atgtccagcc gcttgatgct ttaaattgcc cgtcatgttc tccggcaatc gtctcaagcg 2515981 tgcgtgtcga ggtcgtgccg acagaaatga tccgaccgcc attttctctt actttgttta 2516041 aggctgcagc cgtttcttct gacatttgat aaaactctgc atgcatatta tgctcttcca 2516101 cttcatcggc actcacaggg cgaaacgttc caaggcctac gtgcagtgtg atgaactcaa 2516161 tttgcacgcc tttgtctttc agctgctgta agatttcttc cgtgaagtga aggccagctg 2516221 taggcgcagc agcagagcca atttcttttg aatacactgt ctggtagcgc tctttgtcat 2516281 caagctgttc tttgatatat ggagggagcg gcatctctcc aagggattca agcacctcgt 2516341 agaaaatacc gtcatattga aattccatct ttctgccgcc gtgctcaagc tcttccgtgc 2516401 agattgcctt caatcttccg tctccaaatg tgacaacagt tccttttttc acccgtttcg 2516461 ccggtttggc aagtgtttcc catttatcac cggtttcctg tttcaacaaa agaagttcca 2516521 ctttcgcgcc ggtatcctct tttgtgccga ataaccgcgc aggcagtacc cgggtattgt 2516581 tcaggactag acaatcgcct tcgttaaaga agctgataat gtgtttaaac gagctgtcag 2516641 taagctctcc tgtatgttta tcgagcacca tcagccttga agcatcacgc tgctccaacg 2516701 gtacttgtgc aattaaacgt tctggtagtt caaaatcaaa taaatcgact ttcatgatga 2516761 tttcaccttt attctagtct tttgttattt cattctgcca aaaagattaa gcaaaattga 2516821 taataccaca cttataataa tacaagtgac aaccgggaag aaaaacgtaa catttccttt 2516881 ttttacaaaa atatctcccg gcatcttgcc gacaaaatgc aaaactgctc cgataataag 2516941 caaaacagca ccaagaatca taatgatctt aggaaattca gtcatatcgg ggagcctcca 2517001 tttggaaatg atgataaacg gccggtgtca cgatccttcc acgcggcgtt ctttgtataa 2517061 atccaatttg cagcagatat ggttcatata cgtcttcaat cgtatgcgat tcctcgccga 2517121 tggtagctga aatcgtatca aggcctactg ggccgccgtt gaatttttcg atcatgccca 2517181 tcagcagctt atgatcaata tgatccaaac cgaggcggtc aacctgaagc cgctccagcg 2517241 cattctgaga aatgtcttcc gtaatcctgc tgtcacccag cacttgggcg aaatcgcgca 2517301 cccttctcag caggcggttc gccacgcggg gcgtccctct cgatcttctt gcaatttcaa 2517361 gagccgacgg tttatcaatc tcaacctcga atacatcagc ggttcttgtg acaatatccg 2517421 ccagttcttc ttgtgtatag tactcaaggc gagacattac gccgaatctg tctcttaaag 2517481 gagccgtcaa aagccccacc ctcgtcgtgg ctcccaccag cgtaaaaggc ggaaggtcga 2517541 ggcgaaccga gcgggcagat gggcctttgc caatcacaat gtccaggcaa aagtcttcca 2517601 ttgcaggata aagcacctct tcgatcgatc tgtgcagcct atgtatttca tcaataaata 2517661 atacatctcc cggttccagc gccgttaata tagcagccaa atcaccaggc ctttcaatcg 2517721 caggccctga tgtcgtccgc aattccactc ccatttcatt agcaacaatc gaagcaagcg 2517781 ttgtttttcc gagtccgggc ggcccgtaca gaagaacatg atccagcgtc tcctgtctca 2517841 ttttcgccgc atctataaac acgcgcaaat tttcttttac cttatgctgc ccgatatact 2517901 gtgccagatt ttgcggcctc aggctttgct ctatcactga ttcatggttg tctgcttcac 2517961 ttgagacgag ccgttcatcc atgaacatca ccttacttta atagtttttg taatgctttt 2518021 ttcacatatt ggtctgttgt cagcccaatt tcttctttaa ggtgaggaag cacctttttg 2518081 atttcttttt cagcatatcc gagaaccctg agggcttcaa gtgcttcttc aagagccgtt 2518141 tccgctgttt gcttttcaag cctttcttca tgattaaaca gattttcaat catttcaggc 2518201 acaacatctg ccagctttcc ttttaaatct agaataatct ggcgtgcggt tttctttcct 2518261 actccaggaa acttgaccaa aaaagcttca tcttcatttt caattgcttg gatgaccgct 2518321 ccgggatcac ccgagcccaa gatggcaagt gctcctttcg ggccaattcc ggtcacgttt 2518381 aacagctttg taaagagcgc cttctcctct cttgttgaaa aaccataaag cgaaaaagca 2518441 tcctctctga tatgatggta tgtaaaaatc gtttcttggc ttctctcctt atatataaac 2518501 ggattcggcg tgaaaatctg atagccgatg ccgccgttct ctatgacaat atattgggga 2518561 gatacataat caatcgtccc tttaacaaat tcaatcacgc aaattcacct ctttgactgt 2518621 tcttcattgt accataaaaa cagccaaagt cttatagaaa agttaacata tgttcgcttc 2518681 tctctcattc tttcacgaaa aaaaagacat gaatacatgt cttcaatcag cggacgctac 2518741 ccgctgtatg tcttcatatg ttcgatgaca tcctcaaact ccgcttttgt ccgaaatgga 2518801 atgcctttca gcagattttt ttgcatatgg ctttccagcc tttctaaatc aatttgaaaa 2518861 aaagactgaa ttggttcgga agctggctca ggccgcccat gaaaagtgga aatcactcca 2518921 ttatccgata caccgatata cccgttgacc ttgctgagcg gagaaatatc gtccatttgc 2518981 ttccggaaga gcacatatcc ctttttttgt tccactagcg tccatccggc ataagctgcc 2519041 caaaaatcat ccatagaaaa cactttttca tgcttatgct caatgctgac atcgccgtcc 2519101 aaatacacct tttcaagctg cacatgcacc tgcagcggct catagtgctc cacttccgcg 2519161 ccaagtgcgc gggaaggagc tcctattaaa aatactgccg ctgagcaaag aatgcccagc 2519221 aaaagatacg ccgtgctgaa tcgtttcacc ctctacacct ctttgcacac gtttatgatt 2519281 agtttgacca aagaggctac tgcttaaccg ttttatcaaa atttgtctgc acattttccc 2519341 tgacaaaccg ttcctccgta tacacatctg tgctttgctc agaaattgtc aagaatcgcg 2519401 tcagaaaggc actgaaaaaa tacaatgccg caaagatcca aatcacgcca cctgcaccga 2519461 gcggcccaat gaaaagactc acgatgcccg gcgcgataaa cgcacataaa ccagatccca 2519521 aattcaacac tgacatggca gcacctttat tatcaggtgc aagcgtcggc aaaagcgcgc 2519581 ttaatgggac gtaccctgct aaagccgcgc cgtagcagca ggcgataatc atgagcaccc 2519641 aatactgatg cccgatcagc tgaggcgtgt aatacagcgc cagcgtaaaa ataccgcatc 2519701 cgacaccgcc aaaccacatg accgtattgc gccagcctag tttatctccg actgcaccga 2519761 aaatgatatt aaacacaata ttcacaaaaa acagcgtccc ccatatttgc agccattccg 2519821 aaaccgaata cccgtatcgt gctaaataag taggaagaaa gatggcaaat ccaaattgtc 2519881 ctatcgcatt aatcgtcttg accactccgc cgatgcctac cttagggttt tcaaacataa 2519941 tcgtaaatgc cttcgacagt tctttccatt tcggctgatc ttgtttttgt atcggagtaa 2520001 atttatcttt gttaaaaaat aaggcaagaa ttccgcctgc cgccacaaac agtaaagcgc 2520061 tccaaagcgt attgatttct ccaaaggccg gaactgcata gctggaatag aacggaccga 2520121 gcacgttaag gccgcacgta aacataaacc aaaaccagcc gacggctttt ccaagaatat 2520181 tttgagaggt gctgtatgac acccatacga gaaaagagta tgcaaacagc ggatatccca 2520241 agcctctaag agcatagctg cccaagagag ccggataata catatgagga atcgcccagc 2520301 cgataaaagc ggccgaaccg aggataaatg caagcaatcc gacagtcatc gtttttctcg 2520361 gcccccaagt ttggacaaac gttcctgaaa gccaagctga gatggtgaca gcaatgccgt 2520421 acatggtaaa taacgatgcg gattgctgca tactgagacc atgatcaacg agaaaaggag 2520481 acagccagcc ttgttcgagg ccgtctccaa ccataaagat gacaacgcca atataacccc 2520541 aaaccatgtg agaaggaatt ccgattttgt tcaaaacatt tcctttagca tgtactgtat 2520601 tcattttctc caccgcctac ttaaagtatc aatggagtat atacccaagc ttgctgaatt 2520661 gtaatcctgt tagattaaaa agcgattttt tcagtgtgct caatgctaac aggcatgcca 2520721 aaagcaagcg attgctgtgc tgctctggcg atcctcccgg cctgtaaacc gtcattgccg 2520781 gtgcagggag tctcctggtt tgtgccgatc gcttctgcaa aacggagaat ctcctcctca 2520841 tatgaatcct tatagcgttc aaggaaaaag aaatgcggtt tatccttcat cacaaaatca 2520901 gctgttgaca cctcaaccgt tgtcggcctg ctattgtcag ccgctgcaga gcctttcgtc 2520961 ccgaaaacct caacccgctg gtcatatccg tacacagctt ggcggctgtt atcaatcaca 2521021 gccatggcac cgttttcaaa agtcagtgta ataacagctg tatcaatatc acccagctcc 2521081 gcaaaagaag gattcaccaa agccgcccct ttggcataca cttccgtcac ttcgcttccc 2521141 ataatatatc tggccatatc aaaatcatgg atcgacatat ccataaacaa tccgcctgac 2521201 gtacggacat aatctatatt cgggggttct gggtcccggg acgtgatttt taataaatga 2521261 ggtgtaccga tttcaccatt ttcaacaatc gttttgattt tcttaaaatg aggatcaaag 2521321 cggcggttaa atccgacttg aagtgttacc ccgtgtttcc ggacagccgc aagcgcttca 2521381 ctcgtttcgt ccagagagaa actaacgggc ttctcacaaa atatatgctt tttcgcctcg 2521441 gctgcttctt tgatcatctg tgcatgtacg gctgtaggag agcaaataaa aatagcatca 2521501 atatcaggat catgtaataa atcacgataa tcagaggtta tgtattcaat ctgatgactg 2521561 tcggcccagc tttttatacg gctcgcctga atgtcagaga ttgcttttat tttcatgtga 2521621 ggaatccggc ttatattttg aacatgaagt ttgccgatgc ggcctgcacc gataatccct 2521681 gtcacaatct gttttgtcat ggcttcttcc cccttgatca ttcacgaaag cgctttattt 2521741 aaaattaata ctatcccatt tgtaagcgct tttcaagaat ggaaattaaa cgttctatgt 2521801 ctcttttatc acaattcatg cttataagta gccttcttct tcaagaccag atacactaga 2521861 attaggctct ttttcctgaa cagtttatga ttttcctata aacagctgca taaaatagag 2521921 caaagaaggt gaatgaaatg ctgacaaaag cagaggcact ggcccatacc gtcatatacc 2521981 gcaagaacag cagatttgat aaagtcaaag agaaatccga ggaattaaca ctaatcggca 2522041 agggaagaag cgcctatgtg tttgccttaa cagaaggcgg tcgaaaaatg gcgctgaaag 2522101 tattttttcc ggaatatcaa gcgacagcag tcaaagaagc agcgatctat gaaaaattag 2522161 ccgggtccgc attctatcct gacatttacg aaactggcga ttcatttatt ctcatggaat 2522221 atattaaagg tgaaaccttt tataactgtc tgaagaaagg cattgcaatc agtgatgaca 2522281 tgattcagca ggttgaagaa gcgctttctg acgcccgggc agccggactg aacccgtcag 2522341 atattcattt gcggaatctg atattgacag aaaccggggc ggtgcgggtg attgatgttg 2522401 cgagatttga gcagacaaaa acatgcacgc agtgggacga cttaaaatcc gcatatcatg 2522461 cactctacaa aaaaccgata ttccccaaaa agattccggg tttttggctg gagatcatcg 2522521 catttttata taagaaagat tggtttcaaa agcatttcgc acagcggaaa agaaaatatt 2522581 cttaaatcaa aaaggcagcc gcacaagcgg ctgcctttat catgtatttt ttactttctg 2522641 acggcagaaa tcagtttcat ttgttcaggc gacagcttaa ttcgatagcc tctcacagtt 2522701 aagtagaccg cttctgggtc cttctcgccg gaatgacaat acgttttttc catttctgtc 2522761 tcccctcacc ctttattggc tttatttcat cttatcattg ctttattgag gtaattttaa 2522821 agaaatgtaa agattatatg aatccgatat atagtaaaat gagagaaaaa aagggagaga 2522881 gtcacattaa gaccgaaaac accttgagct tagatgcagc cagaggtgaa cttgtaaatg 2522941 aaaaaacact tgtcaagaga acaatctact ggaattaccc ggacagccgc ccagcagtga 2523001 cgtggatcaa tcacaataca gtgaaaatcg gcaatcagac tttacatctt gatactgatg 2523061 aaacgtatga ttggcgaaaa gatgatcatt ggatccgtga agaaccgccg caggcgtcag 2523121 tgaggtgatg aaacatgaat aagatgaacg gaacaaatga tgaaaagcat ttcaatcatt 2523181 ttgtgattgc tttatccttt atatacggtt tgactgaact aggctatttg ttgctgaagg 2523241 attttataac aattgccata agtttgcctc tgtagaaaaa cgcagcgtag tcgatacgcc 2523301 gcgttttttc tttttccctt cctcttctta ttgataatta caggtcatat aatgtgacaa 2523361 atcgattgta gaaatagttc gattagacca aaatcctttt tatacatgta ttcgaatttg 2523421 aagtgagggg gaagcttgat ggcagatttt gttgctagtt tgaatgcggt cttatggagt 2523481 acgcccgtca tttatatttt attgggaatt ggattcgcct tttcaattat gacccgtttt 2523541 ttacaagtcc gacatttaaa agaaatgatt gttcagatgt tcaaaggcaa gagctctgaa 2523601 gccggcgttt catctttcca agcgttatcg attgcgctgt ccggccgtgt gggcacagga 2523661 aacatcgcgg gagtggcgac agcaattgca ttcggcggac ccggtgcagt gttctggatg 2523721 tgggcgattg cctttatcgg ggcggcgagt gcctttgtag aatcaacgct tgctcaaatt 2523781 tacaaagtga aacaagacgg tcaatatcgg ggcggccctg cttattatat agaaaaaggc 2523841 ttaggcatta agtggtttgc cgtcttattt gccgctgctg cccttattgc aatggccttt 2523901 ctaatgccgg gcgtacagtc caactccatt gcggctggga tccaaaatgc attcggcatc 2523961 tctcctttcg tcacagggtg cggtctggtt ttattattag ggttcattat ttttggcggc 2524021 gtcaaacgaa ttgccaatgc ggcgcaaatg attgttccat ttatggccat tggatatatc 2524081 ctgctgtctt tgattattat tgtcatgaat gtgtctgaat tgcctgctgt gatctcatta 2524141 atattcaaaa gcgccttcgc attggattcc gcttttggcg gcttgatcgg tatggcgatt 2524201 tcctggggcg ttaaacgtgg catttactca aacgaagccg gccagggaac aggcccgcat 2524261 ccggcagctg ctgcagaggt ttctcatccg gtcaagcagg gactggttca ggcattttct 2524321 gtttatattg acaccttgtt tgtatgttcc gctacagctt tcatgatctt gtttaccggc 2524381 atgtacaata cccaggctgc agatggttcc tttatcgttc accagcttaa aggcgtagaa 2524441 gcaggacctg gtttcacaca agcggcaatt gacagtgttc ttcccggatt cggtgcaggc 2524501 tttgttgcca tcgctttatt cttcttcgct tttacaacaa ttatggcgta ttactacatc 2524561 gcagaaacaa atatcgccta tttagcacga ggcagagaaa gcaaatgggc gatgcttggc 2524621 ttaaaactga ttattttagc cgccacgttc tatggtactg tgaaaacagc ttcacttgct 2524681 tgggcattag gggatgcagg gcttggcatt atggtatggc tgaacgtcat tgccattgtg 2524741 ctgcttgcca agccggcgct ccttgcttta aaggattatg agcgccaaaa gaagcagggc 2524801 ttagacccga tctttgatcc aaaagcgctg ggtatcaaaa acgctgattt ctgggagaaa 2524861 gaatacactc atgaaagtga acgtgtctcc tgaacatact aaaaccggcc cgatatgacc 2524921 tcgtgccggt tttttatgaa cgatagtttg tatacacttc ttgaacatca tcgtcatctt 2524981 caaggacgtc tattaatgtt tccagcttct caacagcctg atcatcggct tctgcatagg 2525041 tattgggaag catggtcacc tccgccgaag aaattagata tttcgattcg agggctgttt 2525101 tcacctcttc aaaatgctca ggctctgtga aaacctcata taggtcttct tcaattcgca 2525161 gctcttctcc tcctgcttca agcacatcaa gcatgagctc atcttcttct atttgccgtt 2525221 cagtacggtc tatcgtaatg aacccctttc gttcaaataa aaaggctaca catccgcttt 2525281 ctcccagact tccgccattt ttattaaagg ctgtccgcac atttgacgcc gttcggtttt 2525341 tattatctgt tacgcattca accatgacgg caatccctga agggccgtag ccttcatagg 2525401 tgatttcttc atagctgctt ccgtcttggc ctcccgcagc ttttttaatg gcccgatcta 2525461 tattttcatt cggcatattg gcgccttttg ctttttcgat gacaagacgc aatgctgaat 2525521 ttgcttctgg atccgctccg ccttctttcg ctgccacata gatttctttt gccagcttca 2525581 taaatatttt cccgcgcttt gcatcctgtg cattttttct tttttgaatg tttttccact 2525641 tggaatggcc tgccatgttt tcaccttctt ttacattttc tatgtacact ttaatgggaa 2525701 atgttcgctg atgcaaagaa aaaggctgcc gaatatcact tccggcagcc cttccttcct 2525761 agcggttgtt cattttatga agttttctga acagcccttt atctgttgat acttggacgt 2525821 cacggccatt tgcatagttg cgcgctgctt ttacaacatt atctctgtca gactttgtga 2525881 actctctgtg gcttttgact gcgataacta ctcggtcatc cgataccata acttgtgtgt 2525941 cattgacgtt tttcacttgt ttcacacggt tggcaatttt tgcagccagt cttctgtttt 2526001 cttggttgtc atacccgttg ttcgctgcat tccgattcat gtttcggtta ttcgtgttgt 2526061 tatatgttcc gtcagttgcc aaaggaacac gatcgtcagc agtaacacgg tcacggttat 2526121 ttacattcgt ggtgtttcgg ttaccgtcgt tctgatcctc cattaattca gaaacaggac 2526181 catcgtggtc gattccgtct ccctgtctat cggcgtcatt ttcatttgta taatatccga 2526241 ttggacgggt attgccgtta ttgcgcgtat cattcatagc attatcgttt gctccgcatg 2526301 ctgttaagcc ggctgtcatt agaatcaggc tagcgatcgt cattttttta cccaatggaa 2526361 aaaccccccg tggacgaatt gagcatgttt gctcgctttt atcatgtgcg tatggggggc 2526421 atgttaagcg tgtcagttct ctccatttgg cagtgatctg cttgaaaaca aaaaaaggaa 2526481 cgatttacat cgttccgaac gatcactcat tttcttcttc cggacggcca aacatttggt 2526541 ttacagaagg ctggttcgtc attggcatag aaactcctgc cgaatatggg tttggatttg 2526601 ggttagctgt gccatatggc atattagggc ttccataagc tcccattccc gaatggccag 2526661 gtgcagagaa atatggctga tgatcaccgt cacagccgca gtcgtcatga tctttgtatg 2526721 gcatgtaacc atgagccgca gcaggctggt atgctcccat tacttgggga gtgccgtaat 2526781 aagggccata cggcatatgt ccatacggag atccataagc cggagatgcg tattgcggcg 2526841 caccgtatga accgtaatgt ccgtgatggc tgttttcatg atgctggttt tcataacccg 2526901 ggtcatactg aggcgataca aagcctggct ggtatccatg catcggatgc attggataag 2526961 cttgtgccgg atagtacgga tagcataatc ctgatcctgg aagaattggc gaaacaggca 2527021 ccggacacgg tacgaaatga gccggataat gataataagg ctgaacagcc ggcatcggca 2527081 tattcggaac tgtgtgatga acgttttcct cttctatacc gcctacctct ggcgcctttg 2527141 gcatattagg catattcgga taatttgcat tttccatatt actcatagcc tcctgttgtg 2527201 gaaattggtc ttgcatatga tacatatgat ccatatttcc gtcatgatgt tttttcggct 2527261 cctccggttt aggaggcgac caaggctgga aaagctgttt catatcataa taatcgttca 2527321 catcagcttc agggtacaca ttttcctgca aattaggcat cggcgggaca tacggcatgg 2527381 acttcttttc tttcggcttt gtgtcttcta catcgacaac ggatttaggc ttctctttcg 2527441 catatggatg ttcttgcttc acactcccgg ccgcaggact tttgcccgct tttggctctt 2527501 ttctgaccgg gactccttct gacggcactt ttattttcat tccaggcatg attaagtctg 2527561 gattgctaag ctgtgtattg agttttttca cttcctcaac atcgactccg tacttttcag 2527621 ctattttcca gagcgaatcg cctttttgaa cgatatggat tttcaacgtt ttcccctcct 2527681 atgcaaaacg tgaacagttc agctgtgatt acaatatgtt tcttcacaac atatgcctga 2527741 acaaaagaag ttatgagtaa aggaagggaa aatatttctg atctacgtga tcgaaagcat 2527801 tcgattcagg gcaaggagtg catcttcctg aatggctttt ggcaccttga tgacgcctga 2527861 aggttctcct ttttcaattt gttccagcga ccacaacaaa tgcggcaaat caattcggtt 2527921 cattgtcagg caagggcaca tgtcagggtt gagtgattcg atttgtttat ctggatgctc 2527981 gtgaatgatc cgctgaacaa gattcatttc tgtcccgatt gcccacttgc ttcccgccgg 2528041 agcctggttg attgtgtcga taatatattt cgttgatccg ttatcatcgc ttagtgtcac 2528101 gacttcgtgt gaacattccg ggtgcacaat gatctgaatg tcggggtctc gctctctcat 2528161 atcatggata tttttagtgg tgaatttctc gtgaacagag caatgccctt tccacaaaat 2528221 cactttcaca ttcgtatgcc cggattcagc tactaattca tctttcatcg gatcccacac 2528281 agccatatct tcaagcgcaa tgcccagatc ataagccgta tttctcccta aatgctgatc 2528341 aggcaaaaat aaaattcttt ttttctgtgt aaacgcccat tcaagcactt ttttcgcatt 2528401 cgaagaagtt acagttgctc cgccatgctt tccgacgaat gccttgatct ccgcagtgga 2528461 gttcacataa gttaaaggta tgatcgtatc tccaaatata tgctgaagct tcttccatgc 2528521 cctattggtc tgctgcatgt cagccatgtc agccatagaa catccagctc tcatatctgg 2528581 caggacgacc gtttgctgct cgcttgtcag catatcggcg gtttctgcca taaagtgaac 2528641 gccgcaaaat acgatataat ccgcttcttt gtttttttcc gctacttggg ccaattgcag 2528701 ggagtcgcct gtttggtcag caaattgtat cacttcatcc ttttgataat gatggcctgg 2528761 tataaagagc ctgctgccga actttttctt aatggcggca acgcgcgttt ccatatcctt 2528821 tctcgatagt tctttataac tttcgggcat catatcattc gattgtttga tcacatcaag 2528881 aattgacata acagcattcc tccacagatt catttgataa cgtaacatcc atgctgatat 2528941 ctaaactttt gacggaatga gtcagaaatc ctaatgaaat ataattcaca cccgtccctt 2529001 taaaagcagg caaagattct aacgtaatcc cgccagaggc ttcagttttt atattagccg 2529061 gtgtgagctt tgcaaaatga cggaccgtat caggcggaca gttgtcaaac ataataacat 2529121 ccgctccagc tgcaattgct tcccgcagct gttcctccgt ttcaatttcc acctcgatat 2529181 ttaccatgtg ccctgcggcc tgacgggctt ttttgcacgc ctctaaaata gagccgcatg 2529241 ctgcgatatg attatcttta atcatgatgc cgtcatacaa accgaatcga tgattatacc 2529301 cgccgccggc tctgacagca tatttctcca gcattctgag ccccggtgtt gtttttctcg 2529361 tgtcacaaat tttaatctgt tcatcatcca gacaccgaac agcctctctt gtcattgtcg 2529421 caattcctga cagcctctga ataagattta atacgacccg ctctcctgaa aggagcgcag 2529481 ctgcgggacc gtgtaactcg gcaatcactt cacctttatg caacatgtcc ccatcttttt 2529541 tgtgtaaaat gctttgaaca ttttcgtcca ataacgaaaa gccttctttt atgatcgctg 2529601 ctcctgcaaa aataccctct gactttgcaa caatctccgc ttcacagctc tgttctccaa 2529661 aaatagactg cgatgtaaga tcccctgtcc caatatcctc aagaaaaaag tgattcagta 2529721 attttttcag ctgtaaatga ttcattgttc caaatcccct cgttttttct gatcttcgtt 2529781 cctttttttg tatggacaat ttgtcttcct tgccagctca cctcagcatg aggaaaatcg 2529841 gtgcggaagt gagcccctct gctttcctcc cgcaaaagcg cagaaaacgt catcagcttt 2529901 gcagtttgcc atagatgaga aagttccatc tgccgaattg tgatatcctt cacatttact 2529961 tcctgaaaag gcagcgtatg aagccagatg ctaagctcaa tcaaactgct ttgttcccgc 2530021 agaatagaca tgtggcttgt cattttgctt tgcagttcat gcccctctat atccggcacc 2530081 tcgtagaaga cactggtttc tagccctgat tgatattgcc tgttataaac cggtttttgg 2530141 ataatatgct ctgctgccct ttttccaaat accagcgctt ccaataaaga attgcttgca 2530201 agccggtttg ctccatgtaa accggagcat gctgtctcgc caatcgcata aagccccggc 2530261 actgtcgttt ctccccagcg attaactgaa acacctccca ttaagaaatg cattcccgga 2530321 gcaacaggaa tttttccgct gtggatatca atccctgctt tttcacaaat agcggtgatg 2530381 gtagggaaac gcgtttcaaa atcagaaatc gcactgaagt ctatataaac gcgatttcct 2530441 tttgccattt cttcgtgaat aacccgtgag acaatatctc ttggagccag gtcacctaaa 2530501 ggatgccgtt cagccataat cctgcggccg ttttcgtcta ctaaacatcc gccttcccct 2530561 ctgacagctt ctgaaacaag cccgtaggaa acaccatttt tcacaagcag tgtcgggtga 2530621 aactgagtaa actccaaatc cgttaattcc gccccggccc ggtaagccag agaaagaccg 2530681 tcacctgtga cagtgagatc attcgtatgg tgaagaaaca ggtttccaca gccgccggca 2530741 gccagcacaa cttcgtctgc gtgccttacc ttgagccgcc ctttgctgtc ttttgtcatg 2530801 acgccgatac atcgtccgtc ctctataagc aaatctgctg ccgtttcatt ctcgattaac 2530861 ttgattttgc tgttgatccg tttgagcaaa taatcgataa gcagcctgcc tgttgcgtct 2530921 ccgcctgcat gaaatatgcg gttgtatgag tgggcccctt ctcttccaag acaaacaccg 2530981 cctcgttcat tgcggtcgaa tggaaatcca cgctccaata ggctttgaac catcattttt 2531041 ccatcatgta atacgtctgc tacaatagct agattattat ggccgcaccc tgcgtataac 2531101 gtatcctcca gatgggcttc aatcgagtca tcttttgcat aggccgcagc aatcccgcct 2531161 tgtgcataga cagaattgct gtttttgacg cttttttttg tgataacagt cacttcgtat 2531221 gagggcggga aagctgcagc taaggaaagt gccgccgccc ctgaaccgat gactgcaatc 2531281 gtctttttag acatatgcca tcctcctgtt gtttacacct gtcttgacac ctatatttac 2531341 acaaggataa aataaactca agagtttttt atggagaacg gatggaggaa gaccggatga 2531401 tttatttaga ttatgcagcg acaacgccta tttgtgagga agcccttact gtatatcaga 2531461 agcttagtat ggatatgtac ggaaatgcca gcagcctgca tgatgcagga ggaaaagcaa 2531521 agcacatact ggagtactgc cgtgaaaaaa tcgccaacat cattggcgga gaagcaagcg 2531581 gcatctattt tacaagcggc ggcactgaat ccaattttct ggccattcaa tcattgttaa 2531641 acggcctgcc aaaaacgaaa agacatttta ttacgactgc catggagcat cagtccattc 2531701 ataattgcgc tgcttttttg gaacagcagg gatatgatgt aacagtcatt gaaccgaatg 2531761 aatacgggct tattaccgag gaaatattac taacccatat ccggccggaa acaggccttg 2531821 tatctattca gcatgcaaat tctgaaaccg ggatcattca gcccattcaa cacctgtctt 2531881 catacctgca caataagggg attcttcttc attgcgacgc tgttcaaacg tttggaaaga 2531941 tcccgatcaa tacaaaaaat ctgggagtag atgcactctc aatgtccagc cataaaatcc 2532001 acggtcctaa aggagtaggg gcggtctata tccggccgga tgtcccttgg aaacccgttt 2532061 atcctctgac tactcacgaa tacggattca gagccggcac cgtaaatgtt cccgggatcg 2532121 gtgccttcac tgccgctgca gaattgatcg taagcgaaat ggaaaaacag atatcccgca 2532181 atgaggcatt aagaacatac tttctagacc aaatccgtat tcggtctctc cctgtaaccc 2532241 ttgcagcaga cacttcgaaa gcagaatgtc ttccgcatat tatagggtgt ttttttcact 2532301 catttgaagg acaatatgtt atgttagaat gtaatcggag taatatttgc atttcaaccg 2532361 gcagcgcttg ttctgcaggt taccacggtc cgtctgaaac aatgaaagca ttaagaaaaa 2532421 ccgaacaaga agctctgcaa tttatccgca tctcttttgg caggcataca acagctgaac 2532481 agctggaaca gttattacat acgtttacag tgctttggga acaaaagaaa ggagaatttg 2532541 atattgaccg aagaattaaa gctaatgggc gccaacaggc gtgaccagct tcttctgtgg 2532601 ctgaaggaat ctaaatcacc gctgacagga ggagaactcg caaaaaaagc gaacgtctca 2532661 agacaggtta ttgtacagga tatatcgctc ttgaaagcga aaaatgtacc gattatcgcc 2532721 acaagccaag gatatgtata catggatgca gccgctcagc agcaccagca ggcagaaaga 2532781 atcatagcat gtctgcacgg tcctgaacgg acagaagagg aactgcagct catcgtcgac 2532841 gaaggcgtta cagtaaaaga cgtaaaaatc gagcatcccg tatacggaga tttaactgca 2532901 gccatccaag taggcacccg gaaagaagtt agccatttca tcaaaaaaat caattctacg 2532961 aatgctgcct acttatcaca gctgaccgac ggcgtgcacc tgcatacact gacagcacct 2533021 gatgaacatc gcatcgatca agcctgccaa gccctcgaag aagccggcat tttaattaaa 2533081 gactaaaaaa agccctctag tgggcttttt ttataattgg taagactggt atgcacccag 2533141 aagcctcact ttgcagccga gtgcttcaag ctcctgcatg gcccctggaa tcaatacatc 2533201 atcaaacgct ttctcaatat caataataaa gaaataatgg cctaatccgg ttttagtcgg 2533261 acgtgactca atttttgaca ggtttaaatt tctccaagaa aatgcagaca gcactctatg 2533321 cagcgccccg gactgatcat cctgcggcag catgaccatt aaggtcgttt tgggcctaga 2533381 gctcaatttt gaattcactt caaaagatat gttttcatcg ggagacagga taacaaatct 2533441 tgtatgattg tccctataat cctgtatatc ccgtttcacg atttttaatt cgtatgtaga 2533501 agctgccata tcattggcaa tgaccccgat attcagctcg ggatggtcac tgacaaactt 2533561 tgctgccgcc ccggtagaat tggcgtattc atatggaacg gaaggaaaat gtcgatgaag 2533621 aaatttatgg cattgcgcaa tcgcgtgtga atgtgagtaa attttgtcga gctctttcca 2533681 tgcattctct cttgagggat ggacgagcaa gtgctggtga atcggcaacg tcatttcacc 2533741 cacgattggc aaaggctgtt catgtattaa atagtctatt gttagattaa cagatccttc 2533801 taaagcattt tccaaaggaa caaaagcaaa atcaacttcg cctgcaacgg ctgcatctat 2533861 acactccgga atggtgcggt aagcaacatg ttcggcgccg ttttgaaaac aagaactgac 2533921 tgctagatgt gtaaatgtag ctgctggacc taaataaccg actttcatga cgattttctc 2533981 tcccttatgc acctgaacct aatatttcaa ccttttctac aaaatcaaac ttcctgagct 2534041 tattcattaa tgtatgaatg tcttcttcca ttgccgacgt actgatagac agtgtcacat 2534101 ttgctctgcc ttgaagcgga atggtctggt gaatggaaag aacgttgctt ccagaatcag 2534161 ctaccgcctg aagaagctga gataacgcac ctgacctatc ctccaaatga aagaaaagtg 2534221 tgataatttg ttcttttacc atggtgtaga atggaaaaac agcatccctg tatttataaa 2534281 acgcacttct acttaaatcg accttttgaa cggcatctgc tactgaatct gctttttttc 2534341 gatcaagcag ctttttgact tctaatgttt ttctcattgc atcgggcaat acatcttcac 2534401 ggacaagata aaatgtctcc tctttcattt gcatcccccc tttaaaatag agagcctggc 2534461 accaggctct cttttcagcc aacattgatt aatcaataaa ttcaaattca aattccagaa 2534521 gcctgattat atctccatcc ttggctccgc gttctctgag tgcttcatca acacccattc 2534581 cgcgcatctg tcttgcaaac cgtttaaccg attcatcacg tgagaaatca gtcatcttga 2534641 ataaccgctc aaggctgtct cctgaaagca caaatacacc gtctggatcg cgtgtaatgt 2534701 taaatggcac ttcttcattt tccatcgtgt acatgacacg gttttgtgta agctcttcct 2534761 cgtcatacag cgggaattcc ggtgtgttct caagctgatt ggcaacctca aacagaagct 2534821 cacgcagacc ttctcttgtc accgcactga tcgggaatac cggataatca tccgtcagct 2534881 tttctttaaa ggcttcgaga ttttccgcag cctccggcat gtccatttta tttgcaacga 2534941 taatttgcgg acgctcagtg agacgcagat tgtactcgct cagctcctgg ttaatcgtaa 2535001 gataatcatc atatggatca cggccttcta agcctgacat gtcaatgaca tgaacaataa 2535061 ccctcgtccg ttcaatatgg cgcaaaaact ggtggcccag tccgacgcct tggtgtgcgc 2535121 cttcaatcag ccctggcaaa tcagccatga caaagctgcg tccgtcatcc gtttcaacca 2535181 tgccgagatt cgggacaagc gttgtaaagt gatagtccgc aattttcggt tttgcagatg 2535241 agacaacaga cagcaaagta gattttccca cactcgggaa cccgacaagt ccgacatctg 2535301 caagcacttt taattcaaga acaatgtagc gttcttttcc cggctcgccg ttttctgaaa 2535361 gctgaggcgc gggattagcc ggtgtagcaa agcggctatt tcctcttccg cctcttccgc 2535421 ctcttgcaat gacagcccgc tgtccgtgct ctgttaaatc agcgatgacc tgttttgtat 2535481 catcgtctgt cacaacggtg cccggcggaa ctttaatgac catatcatca gcatttcgcc 2535541 cgtgctggtt tttggacatg ccatgctcgc cgcgaatcgc tttaaagtgt tttttgtatc 2535601 taaaatccat cagggtgcgg agaccttcat ctacttcaaa aacgacgtct cctccctttc 2535661 ctccgtcacc gccggcaggg ccgcctttcg gcacatattt ttcacggcga aacgcaacca 2535721 taccgttgcc gccgtcgccg ccttttacat atactttgac ctgatctaca aacataatgt 2535781 cctccgttct aaaccgttaa aaactccgct agtccaaccc aatttcaatc agacattcgt 2535841 gactcgtgat ttcaaaacgc atgatatcaa cgtcctcata tccattctgc cgaatatcat 2535901 caaaagcaga tggatcggca aaggcgccgt gaaaatcaag gtacagaatc agctgtctgt 2535961 caggatgatc cgtttgaagc gaaaccgtta aatgattttc actctctctg ctgactgctt 2536021 gatcaaacag atgaaacagc tttctcatca gtttcgccag cttttgatca taagccgaca 2536081 aatccttaat ttctccgaga acttcatatt caagcgtcat ataatgggtt ttccaattaa 2536141 acgtaagaaa atcaaacgcc aaatgcggtg ttttcaggtt tgagagcttt gattcgtgct 2536201 ttgcgtctat aaccatttct tcaatcattt caaagacacg gtcatacttc tgtaagctta 2536261 agtttccttt aatcagctgc agcttattca tccaatcatg ccgggaatgg ccaagcagat 2536321 gaatcagttc gtttgttaat gccgtgtcgc ttatattttc ttcttgattt tttgaaacat 2536381 ccttcatttt cgcactccca atcatttaat ttcttattta ggagtctgta taagtgtgta 2536441 ttatgaatta taacagagaa ggctttgtta gaaaaacaat tgtttttccc agaaatatca 2536501 tgttcctttt ttctggcttt ggttgatttg cagccaggca gaacatttta tgtattactg 2536561 cttggggaac atatccagtg ggtttgagat gtttattctc attcttggcg gggtctgctc 2536621 gcacatactc tgcatttcat tctaggtgtt tactccgcat attgcaaaaa aaactccagt 2536681 catcatcgac cggagttttt tgaatcatta ttgagctaca ggatatacgc tcactttttt 2536741 gcggtcacgg ccgaaacgtt cgaatttaac agttccgtcg attttcgcaa atagagtgtc 2536801 atctccgccg cggcccacgt tttcacctgg gtaaattttt gttccgcgtt gacggtaaag 2536861 gatagaaccg cctgttacga attgaccgtc agcacgttta gcacctaaac gtttagcctc 2536921 agagtcacgt ccgttctttg tagaacctac tcctttttta gaagcgaaaa actgaagatc 2536981 taatctaagc atgtagctca cctcctatat tatgtttgtg gtcacacgca agttgtcttt 2537041 gtaatcccgt tcgattgtct ccagcgaaac aatcatgcct tcaatcagca gctgagcttt 2537101 ttggcgtgcc tctggatcaa gagattcagg gaattcaaaa taaaaataac ccccgtcctc 2537161 tcctatatca agaagcggct cgaagcccgc gagcacaatg accgcgttaa cggccccaaa 2537221 cacaacggct gtcactccgg cacaaacaag atcttgtcca tgttcagcaa aattcgcatg 2537281 gcccgtcatt tcaaaagaca atatgccttt atcatgagac cttctgattg ttgcctgaat 2537341 catgcttacg cgttgatttt ttcgatcgtc actttagtgt aaggctgacg atgaccttgt 2537401 tttttatgaa cgtttttctt tggtttgtat ctgaaaacag tgattttttt cgcgcggcct 2537461 tgtttttcaa ctttagccgt tactgttgcg ccttcaactg tagggttgcc gactttcacg 2537521 ttgtctccgc caacaaacaa aacgtcttca aaagtaactg tttcacctgc ttcagcagca 2537581 agtttttcga tgtaaacagt ttggccttct tcaactttga tttgtttacc gcctgtttta 2537641 atgattgcgt acattctctg cacctcctat tagactaaga ctcgccagat accagggggc 2537701 tgtaaaagct cttaacacct gtactgagcg gttgtagcaa tggtgctaca tccataacat 2537761 taaaaaatat accaaaatac aaggcgtttg tcaatcagtt ttagtagggc agaagcagtt 2537821 cctccatgga agaattcgtc cgcttatcgg caaagtaagc gtgcagcact tcattctcgt 2537881 caagctggct gagcttttgg cctgattttt ctataataat cggatgctta cagccacgtt 2537941 tgaactcggc catcacatga tagactttat cctccgcctt tactgtcagc ggcagaagtt 2538001 tctcaagctc cctgtttttt ccgtaatacc tttcgaggag aaatctcaca tggatatagt 2538061 gcctttgccg atattcctca aacaaggaaa cagccagaaa gacaaacaaa acccatgcgc 2538121 tgatttgcag aggaatcacg aataaaaccc agcacccgag cagcaggcag aagcagagcg 2538181 acgtttttag attaagccgg tgagcctttt gaaaaggcag ctgtttggaa aacaacaaaa 2538241 ataacagttt tcctccatcc agcggccaga tcggcagtaa attgacaaat aagatagaaa 2538301 gattataaaa ggtgaagagt tcaaaggtat gctgatgaat cactgagact tctgcaagca 2538361 tccaggcggc aaactgaagc cagatgtgct gaagaggtcc ggcaataatg accgcaaact 2538421 cttcctttaa cggccgattc ccgtgctctt ccacttcgac cgttccgcca aacggcagca 2538481 aaaaaacacg cttgattctc caagaaaaaa acacagccag agcagcatgc cccagctcat 2538541 gaatcaatac aatcaggagc agacataata atgctttcat atggcctgtg agcaagccca 2538601 gcgccgcaat aatccaaaga aaaggatgca catggatctt taagataagg tcgagccatt 2538661 tattcaaatg aaatcacctg aatcggatca ataaatttat cgccgtcttt catggcaaaa 2538721 taatagaccc ctttattatg atcatcaagc ttaatcgaac cgagcttttt gcctttatcc 2538781 acaaaatcat ataaagcaac atccacatct ttgagctcgc catagatact ataggtgttg 2538841 tcagcatgct gcaccttaac cgtcagtccc gtttggctgt ctttgctgac ttcaaccaca 2538901 tagccttctt ttacgctatc aatcttatca ctgcttgttt cgactttaat tccttcccca 2538961 ttgtcctgaa aatcctgctg tactttcccg gatgcaggcg cgatcagatc tttgcctact 2539021 tcaatctgct gttccttatt tttgtgttca ggagccagga aagcaagcgg atttccgaat 2539081 ttggtttcga accaatggct tgctgaagca aattgaaatt cagtttcaaa ggttttggct 2539141 acggcgggtt taatctgact gacgggtcca atgtttgttt tataggctat agctgaaacg 2539201 agaacaaggc aggccgacag aagacatttc aggataattg aatctgtttt caccaatggg 2539261 tgttttccgt tgaatgttgg catgttatct tcgtagaccg gaagtgttcc atgcttttcc 2539321 tgatccgtta ccatcaccca ggacgggggt ttctgctttt cagaaactgt ctgagtagag 2539381 aaacgttttg agccggaaag ctgctttctt cttttctcta atcgttttct gatttcatct 2539441 gctctgtgac tcattgccat catcctttgc attcgttggg tttgtacatc atatgtcttg 2539501 tccatggcaa atattcggtt tagtcaagaa caaagcaggc aaaaacaaaa aaaacctgac 2539561 acagcatatg ctttgtcaga ttcttctctt tgattctatc acattaagat cttactccga 2539621 aaaatgactt aatcttagcc atcattcctt tgttttgctc ttcaagcacc tgtaaaggaa 2539681 cagattcacc taagatgcgg cgggcaatat tgcgatatgc aatggaagcg cggtttttag 2539741 ggtccatcgc aatcggttcg ccatgattgg aagctttaat gacttcatca tcatcagcca 2539801 cgattccgag caaatcgatc gacagatgct gtacgatttc gtcgatatcc atcgtgtcac 2539861 cgtttttcat caggtgattt ctgattctgt taacaacgag ccgcggcggt tcaatatttt 2539921 cctcttgctc cagcagtcct ataatacggt cagcatcacg aacagctgag atttcaggcg 2539981 tagtgaccac aatcgcttta tcagctccgg aaacggcatt tttgtaccct tgctcgattc 2540041 cggcaggaca gtctatgatg acatagtcaa attcctgttt gagctcttgg accatgtttt 2540101 taatttgttc aggagcaaca gctgtcttat cgctcgtttg agcagcgggc attaaataga 2540161 gcagatcatc gaaacgtttg tcttttacga gcgcctgatg cattttgcat ctgccctcta 2540221 caacgtctac cagatcgtaa ataattctat tttcaagacc cattacaaca tcaaggttgc 2540281 gcagtcctat atcagtatct actaagcata cgcgcttccc taaaatggct aaggcggtac 2540341 cgaggttcgc agatgttgtt gtcttaccta ctccgccttt tcccgaagtt attacgatag 2540401 cctcacccaa ttcacattcc tccctcaagc cttgttagat caggtcttaa atgagccaaa 2540461 tgttgaaggc gttcaatgac catatttccg tctgtatcta aataagcaca ttccatttcg 2540521 ttcccttttt gaatgtggtc tggggagcga tttaacacat gattgattct taattgtgtc 2540581 ggaagcattt cagaggcggc gatgaccgct tgattatttc cattgaatcc agcatgcgca 2540641 attcctttca gtgagcccag aacaaaaatg ttccctccgg ccctgactgt tccgccggga 2540701 ttcacgtcac cgatcaggag caagtcgcct tttacctgca gcacttggcc tgaacggaca 2540761 atttttgaaa cagaaataat ttcggcttcc tctcttatct gctgtgcttc ttttttagta 2540821 atgacttcac tgtcaataga atgaacaaac aaatctttct ttgacgcaat caattcggtt 2540881 agctgttcct cttgctcctt atataaaaag cgatttccca gcttaacatg aacgctgatt 2540941 ttctggcctt ttccatcggt atattgttca attgacagca tattctgaag accatcgaga 2541001 agctcatcaa aagaacacgc atcatccaga tgcaatgtta gtccattctt tgttcctttt 2541061 attgttacat attgctgctt tttggtcttc acaatattca cctcaacaac atactcattt 2541121 cgtcaaaaaa agataaaatc ctttttactc atctctcaat tctttcttta gactcataaa 2541181 aaacaatcta aatggcagaa caagaataag agctgctgca atatttaata aaattgtcgg 2541241 tataaaccgg tcaagcacaa atccgttaaa cgtcataatg tctttatgaa tcaaagactg 2541301 aatgccgaat acgtaaaatt cgagcagaca gacagccaga actgctatca atatcactac 2541361 aaatgcgttt gtatgcaaca ctttaaacgc ttttgaagcc aaatagcata gccctgcaaa 2541421 accaaacatg taaacgccta atagacttgt atagttcatg tcatatagaa agccaaaaat 2541481 aaatccgtaa atcatcgcgt gtttttggtt gataaaagcc gacatgaata tcaatacaag 2541541 catcaaaaaa cgcggggcga gcacttggtc atctgtaacg aaaggaaaat gcaccaaatc 2541601 tgtaaaaatg ctttccgcag aaaaaacaag catcataacg aaagggagaa ggaaacgttt 2541661 cacgatcctt cctcctctgt atcgacagtc ggcacgtcac ggttaacaac gatcacatta 2541721 tttaaatctg taaggtcagc cgcaggtttt acataagcaa ccttcgttaa tccataggaa 2541781 tctgactcga tatcagtcac ttcaccgatt gtcagccctt ctgggaaaac accgcctgtc 2541841 cctgatgttt caataagatc gccttttttc acgtcttgtt tatccttacg ctcaataatt 2541901 gtcatcttaa gacgtttttt ctctttgtca tatccttcga tcaagccgta gcctttgctg 2541961 cctttttttc cggaaatttt tgtcgcgact ctgttattgc ggtcagtatc gcttaaaagc 2542021 tgaacagcag acgtaaaatt gttaagtccg gagcttttga tcttgccgat taatgcgcct 2542081 ttttcgtttg taacggccat atctttcgct acgttttgct gagtcccctt gttaatggtg 2542141 acctgtttcg cccaattatc agggcttctg gcgatgaccg ttgctaaaat cggcttgtaa 2542201 tctttaatcg atttgacatg gccaagctcg tcacgcaagg atttgttttc ttcttcaagc 2542261 tcttgaagct tggcttcata ttgtgtctgt ccgtcaagtt tttctcttag acgctcgttt 2542321 tctttgtatg tgttttttaa atcattgatg ttctcaaata ttcctgcaaa aaattcggca 2542381 ggcgtatgaa aaatattttg aaatactccc gtcgtatcgc cgatcacttt ctcaggccag 2542441 gtggtattgc ggccgccctt cagcgaaaat ccaatcatag ccaccaatat gataatacac 2542501 agaagtaata gcattaaccg cttattcggc atcgtgttac acctcttcta ttgaactccc 2542561 gattatctag ttttcccttt gaaaagatgg atgtgctcca gtgctttccc tgttccgatc 2542621 gctacacaat caagcggatc ttcggcgata aggaccggca tttttgtttc ttcgctgatg 2542681 actttgtcca aattgcgcaa aagcgctccg ccgccggtta acactatacc tctgtccatg 2542741 atatctgctg caagctcagg cggtgttttt tcgagtgtgc tcttcactgc ttcgacaatt 2542801 gtagatacag tgtcgcgtag agcgttagaa atctcttttc ctgtaatttc aattgttttc 2542861 ggcaaacctg tgagcaaatc gcggccgcgg atttccatgt tgtcggattc ttcaggagct 2542921 tctgcagatc cgatttccat tttaatcgct tcagccgtac ggtcaccgat catcagattg 2542981 tacgtttttc tgatgtagtt gataatcgcg tcatccatct catcaccggc tacacggatt 2543041 gactgagacg ttacgatgcc tccgagggaa ataatcgcaa cttctgtcgt accgcccccg 2543101 atatcaacaa ccatgcttcc agtcggttcc caaactggca gattggctcc gattgctgcg 2543161 gcaaaaggct cttcaatcgg atacgcgtca cgcgctcccg cctgtcttgt cgcatcgata 2543221 acagcgcgtt cttcaacagc tgtaatgcct gatgggacac ataccattac atatggtttt 2543281 ctggcaaaca tgcctttatt ttttatggcc tgattgatgt aatatttcat catcgtcgcc 2543341 gttgtttcat aatcagcgat aacgccgtct ttcatcgggc gaagagccac cacgttgccc 2543401 ggtgtccgtc caatcatatt tttcgcatca tttccgacag cgacaatcga tttcgtatcc 2543461 gtctgcaaag cgacaactga cggctctctc acaacaattc cttttccttt tacaaaaaca 2543521 agcgtattcg cagttccaag atctatacca aggtctctag caccaattcc aaacatatgt 2543581 atgtatcttc ctttcttaaa gcaaaaatac cctaaaggga aaaactcata aactctatta 2543641 tagcttaatt cgacgaaaaa aaaagtgtta caaatatcct ttttccttta aactcacaaa 2543701 ttttttatcc ccgatcacca aatggtcaag cagctcgatg ccaatcaggt ttccgcattc 2543761 aaacagccgt cttgtcactt caatatcttc cctgctcggc gtcggatctc cagaaggatg 2543821 attatgaaca cagataaagg aagcggcaga tcgtttaaac gcttctttaa acacctctcg 2543881 cgggtggaca atagatgaat tcaggcttcc gataaatacg gtgcgtttat ggatgacttg 2543941 attttttgta tttaagtata aacagacaaa atgctcctgg gttaaaaagc gcatatcctc 2544001 catgacaaga ttagcgccgt cttccgggga gcgaataacg aaatgttctt cgttggctaa 2544061 tttatgaatc cggcttccaa gctcaactgc tgccagtatt tgaatcgctt ttaccatacc 2544121 gattcccggg atgcttgaca gctcttcaac cgatgcttcc ttgagcaggc gcagcccgtc 2544181 aaatgagcgc agcagccggt ttgacaggtc caaaacagat tcgtgtttag tccctgtccg 2544241 caataatata gccaaaagtt catgattcgc taagttctcg gctccgactt tcaggagccg 2544301 ttcccttggc ttttctttca ttgggaaatc tttgagtttt aatggcagat cgtgtatgac 2544361 caagcactcc ttttctttcc cttcccgttt atagaaccgt catgccctta tatcaaaatg 2544421 gcgaagagct ctcattgttt ttgatatagg aaggcccatg actgaataat aatctccgtc 2544481 tattttcttt acaaaaagcg cgcctcttcc ttggatgccg tatgcacctg ctttatccat 2544541 cggctctttt gtttcaatat atgtccaaat ctcttcttca ctgagggacc aaaacgcaac 2544601 ttctgtctta tcataaaaag tctcgctgtg attttcagct tgaatgctga ccgcggttat 2544661 tactgagtga cttcggcctg aaagcctccg cagcatagaa gcagcttctt cttgatcctg 2544721 cggtttgcca agacattcgc cgtcaaggca taccattgta tcagcaccga taacgattgc 2544781 atgcgggtgg agatcagcta cagccttagc tttttgtttt gccaaccatt ggacgttttc 2544841 ttctggtgaa aagtttcgat ttaatttttc ttctacttca ctgacaataa tggagtaggg 2544901 cagctggaga agatcgagga gttctttcct gcgcggagat tgtgatgcaa gtattagcgg 2544961 ttttgtcatg ttcgtcatcc tttcagggtt tgcttaagaa aaaaagatac tcgtttatcc 2545021 taccaaatca cgaggcttgt cacaatttca gaaaaataac tttttcatga caaaataaaa 2545081 aaagcctgtc actaaaggac gaaggctcag ggcactatct cttattttac gacggctaac 2545141 agctcctgct gagccttcca cccggcttca gcacttggat cctctaattc ctttaaagcc 2545201 tgcaaaatcg cttttttctc tcctgtttct gacgcttttg tttcaccaag cgacttttct 2545261 attttctcta cactcgcttt tgtaatgtct tcgtcgagaa tcgcctttgc tgcaagctcc 2545321 gctgtttcct taaaagaatc tgtcatatct gactctattg ataaggaaag ctccttgcct 2545381 ccccaggctt caaaatcact gtcgattaaa acctgtccta actgctgtga gacctccttt 2545441 tcacttgcta agcctgcaat aacatacgta tacccgtcat cctttgacag tgacacggcg 2545501 gaatatcctt tttcggtcaa ttgttctgtt aacgtttcgg cgcccttttc atttgaaaat 2545561 tttccggctt gcacagcgta tgttttgtat gtaccttcag tttgtgccgc ttgtttttct 2545621 gcgcctgagg tttgtttatc agcagaagta tcccctgctt ttgccgtttg gctgcctaaa 2545681 gaatcctcta aagaggccgg tgctgacgct tctttattcc ccgatatgtt taacgcgaat 2545741 aaccctaatc cagtgccaat gacagccgcg aaggcaatcg tcgcggccac tctttttacc 2545801 ggtttggcag ccccggtctt tccttttgcg taaagctttg tttttttctt ttgaaaagga 2545861 ggaacaactt tagggtcctc tttaaacacc ttgtcctcct cggaatccca attgaattca 2545921 tcttcatcag ggtgttcctg ggatgccgca acctcttgtt ctgcctgtct tttttcctcc 2545981 caatttgaaa atgtcatgct tttattcgcc tctgtctcag gcgtctcttg ttcgtaaacc 2546041 gtctcttctt ttccattaat cgtcaccttg agggcttttt ctgcggcttt actgtttttt 2546101 ttattctttc tttttttcaa ttccgcttcc tcccttcatt tgcttgaccg ttcttgtcgg 2546161 cttttcatgc tacacacttt agcacaggca aagaaaaaaa gaacaagact tttgtcgcct 2546221 tgtccaaaaa acgttcgtca aatttttcag cagtcagccc aatgccattt tgatataaaa 2546281 agaaatgata gagtcaccgt ataaataggc taaaatgctc cctgcggcta tagcgggggc 2546341 gaagggaagc ggctgccttt tagcgagtct accagtcaga acagctgccg ctccatataa 2546401 tgcacctatc aaaactgaaa agaaaaaggc agctgccagc attttcacac caagcacaaa 2546461 gccaatcacc gcaaataatt taatatctcc tccccctact cccccatggg tgattgcggc 2546521 aattacagcc agaaacaaaa atccggctgc cgcacctaac aggcctgcat accaggaatc 2546581 aagcggagaa atcaatctcg cggccgccaa aaagggaaga aagaaaatca atattcgatt 2546641 tggaatcagc ataaaatgaa tatctgtcac tgcaacaata atgagaagag agataaacac 2546701 cacagcggga aacagttcca gcgatatgcc aaagcgtatt cctgcggcgg caaataaaca 2546761 cgctgtcaca agctctgctg cgggatacat aaaagaaatc ctatgcccgc agcttttaca 2546821 tttacctttt tgaaatagga atgacaggat gggaattaat tctgcaggag ttaatgttcg 2546881 ccggcaaaac gggcatgatg aacggggcgc aataatagat agatgtaagg ggatacggca 2546941 cccggccgta tagtaaaaag aaccaaggat aagcccgaag ataaaaagaa tggatagcat 2547001 agacaacaca cctttactca ttgagttctg gtatggattg tagcaaaatg gacatcctga 2547061 gctccaattg ggaatattca attttacaca tgaaaaaaac ggcagaatct ttttttgatt 2547121 ctgccggagc cggatgcttt tatttcaacc tttttcgaat gtcagaaata aagtaaagag 2547181 atccggtaat cagcacaatt tcatttgagc cctttttact ttctatgaat ttgattacat 2547241 cgtctggatc ttcactccag cttttattgc tgatttcact tgcatcatag agatcttttg 2547301 caagggaagc acgcgggaaa tcaaaagaag caaaatgaat cgcatgagca atggtttcca 2547361 gtcttttaat catgttctga tacggtttgt cctttaacgc gctaaacacc acagaaatgc 2547421 gtgaattggc gaaacgctgc ttcatcgttt ccgccagctt ttcaacacct tcttcgttat 2547481 gcgcaccgtc taaatatacc ggaggatgtt cctgaacaag ctctaaccgt cccggccaag 2547541 cagccttcac aagcccgctc cttaacgctt cgtcactgat atgggcgata ttctccttat 2547601 tgagccactc cgcagccaaa atggacaaag cagcattttg tctttgatgg gtgccaatca 2547661 gagatgtccg aatatcttca tagcatttct cttccgtttt gaatgaaaac tgttctcctg 2547721 caggcagagc ctcttcattg aaaataacac atgcatcatg caatgactgg aacggcgcag 2547781 catgccgttc ggcttcatgg cggatgacct gtaaagcttc cggctgggta actgctgtaa 2547841 cgattggaat accttcttta ataatgccgg ccttttctcc tgcaatttct tcaatggtgt 2547901 ttcccaaaat gttcatatga tcgtgtccga tgcttgtaat cacagttaag agcggttcaa 2547961 ccacattagt agaatcgaat ctaccgccca gacctgtttc aaaaataaca aaatcgacct 2548021 tatgaaactc tgcaaaatat aaaaatgcac aagctgtcat aatttcaaat tctgtcggct 2548081 gtccgtattc cgtttgatca agggcttcaa cgtgcggttt catttgattg acgagtgctg 2548141 tccattcctc atctgaaatc ggtatcccgt ttacgctgat ccgttcatta aacgtaataa 2548201 tataaggcga tgtaaatgtt ccaaccgtat atccggcttc ctgcagcata gaacggataa 2548261 aagcgacagt tgatccttta ccgtttgttc ctgcgacgtg gaacgctcgg attttttttt 2548321 caggatgtcc taaccgcgcc atcagctgtt tcattcgacc aagtccgggc ttcaccccga 2548381 atttcagcct cccgtgaatc cagctgcgcg catcttgata tgcagtaaac aatgataatc 2548441 ccctctttta taagacaagg cggtttctct agaaaccgcc ccggcttttc attaaccctt 2548501 cagctcagcc attcgttttt gaacagcgtc acgcttcgcc acataatctt tttctttttc 2548561 acgttcttca tcaattacgt gtgcaggcgc ttttttcata aatccttcat ttccaagttt 2548621 cttttggaca cgctcaactt cttttgtcag tttatcaaat tctttttgca gacgggcaat 2548681 ttcttcatca atattgatta agccttcaag cggaagaata acctctgctc ctgagacaac 2548741 ggccgtcatc gccttatcaa cagcctcaat atcggtgccg attttaagca cgctcggatt 2548801 cgtaaagcgt tcaacatatg aacggttcgc ttcgaggcgg gacgctattt cgtctgtgct 2548861 tgttttaatg tacagttcaa cctgcttgct cattggcgta ttgacttcac tgcggatatt 2548921 gcgcacagaa cggatcagct caacaagaag cttcatgtca gctgccgctt cagtatcggt 2548981 atgctccggc actactgcag gccattgact tactgtaatc gattcccctt ggtgaggaag 2549041 gtgctgccaa atttcctccg ttaagaatgg cataaacgga tggagcagac gcatcgtttg 2549101 atcaagtacg taagcaagga tggaacgggt agttttctta gccgcttcgt cttctccata 2549161 aagcggaagc ttcgccattt caatatacca atcacagaaa tcatcccaaa taaagttata 2549221 taaatggcgt cctacttcac caaattcata tcggtcagca agctgggtca cgtgctcgat 2549281 cgtttcattt aatcgcgtta aaatccactt gtcagcgact gacttttcac ctgacagatc 2549341 aagctcatcg tacgtcatgc catccatatt cattaatgca aaacgggagg cgttccaaat 2549401 tttattggca aaattccagg tcgattccac tttttcatag ctgaagcgca gatcctggcc 2549461 aggagagctt ccagtcgcaa ggaaataacg cagagaatcg gctccgtact tgtcaatcac 2549521 atccatcggg tcgacaccgt tgccaagaga tttactcatt ttccggcctt gctcgtcacg 2549581 gattaagccg tggattaaaa catctttgaa cgggcgctcg cctgtaaatt caatgccttg 2549641 gaaaatcatg cgtgataccc agaagaaaat gatatcgtac cctgtcacga gaacatctgt 2549701 cggatagtag cgtttaaagt cttcagccgt tacatcaggc cagcccattg tggagaaagg 2549761 ccatagcgca gaactgaacc atgtatccag tacgtctgta tcctgttccc aattttcgct 2549821 gtcttccggc gcttcaagtc cgacatatag ctcgcctgtt tctttatgat accaggcagg 2549881 aatacgatgg ccccaccaca attgacggga gatacaccag tcgcggatat tttccatcca 2549941 gtgtaaatac gttttttcga aacggtcagg cacaaagttg accttttctt cttttttttg 2550001 cagctcaatc gctgcatcag caagcggctg catgcgcaca aaccattgtg tagaaagata 2550061 aggctccaca acagccccgc ttcgttcact atggccgaca gagtgcatat gatcctcgat 2550121 cttgaagaga actcccgcct cctgtaaatc tttcacgagc tttttgcggc attcaaaacg 2550181 atccatacct tgatattgga gcgcattttc attcatcgtg ccatcttcat tcatgacaag 2550241 gatgcgttct aaattgtggc ggttgccaag ctcgaagtcg ttcggatcat gagcaggcgt 2550301 aattttcacg gcacctgaac caaattccat atcaacatag tcatcaccga caatcggaat 2550361 ttcacgattt acaatcggca ggatcaccgt ttttccgata aggtgtttat agcgctcgtc 2550421 ttcagggtga acggcaacag ctgtatcacc gagcattgtt tcaggacgtg tcgtcgcaat 2550481 ttcaattgag cctgaaccgt cagcaagcgg atagctcata tgatagaatg cgccttgaac 2550541 atccttgtaa atcacctcaa tgtcggatag ggctgttttt gtcgctgggt cccagttaat 2550601 aatatattcg cctctgtaga tcaggccttt ttcataaagc ttaacgaata cttcccttac 2550661 cgctttgctc aagccttcat ccagcgtaaa acgttcacgg gaataatcta ggccaagacc 2550721 taatttcgcc cactggctgc gaataaagtc agcatattct tccttccact tccacgtttc 2550781 ttcgaggaat ttttcacggc ctaaatcgta gcgggatttg ccttcttcac gaagtttcgc 2550841 ctccacttta gcctgtgtcg cgatgccggc gtggtccatg ccaggaagcc acagcacatc 2550901 atagccctgc atgcgtttca ttcttgttac aatgtcttgc agcgttgtgt cccatgcgtg 2550961 gccaaggtga agtctccctg ttacgtttgg cggcgggatg acaacagagt atggctcttt 2551021 tgtctggtca ctgcccgctt caaaaaattt gccttttagc caaaaatcat atcggtcttt 2551081 ttcaaccgct gccggatcat atttcgtcgg cattgtttgt tcattcgttt ccatcataac 2551141 cctccagcat gtttaaaaat ggctgagaac gaaaaaagag ctcttcatcc ctgtaaaagg 2551201 acgaaaagct ctttcgcggt accacctttt ttcatgaact caatcagttc atgcacttat 2551261 aacggataac gggtgtttcc cgaatttctc tactcttctt tcaagaaatt atgctcccgg 2551321 gcgaccttcc aatcagacaa cataagaagc ctttcagcaa acggcttctc tctctgcatg 2551381 cgcctttttt gtactcttcc cgttctaagc aggtgtattt atcagctcat tgtatacatt 2551441 atttatgttc tttattatag taaaagtgtt tttgattcgt caatcatctt ttccaaaaac 2551501 accgctttct atacagatgg gcaggcacct attgcccaag tttacatatg atgcttgtaa 2551561 atgcgtagag gaggatgcac cgtgaagaaa cgtttcagct cttattcgct gccgccatgg 2551621 gtaaggcaaa ttcggcttgt atccgcacaa gtgattattc ccattacgat ttttcaagga 2551681 atcagaacca ttttctttcc gacaaccttt gatgttttgc tgctcgcaat cctaatcttt 2551741 ttagcttgcg cccttcattt agaatggata taaacaaaca agtccgcgcc attaagacgt 2551801 ggactcgttt tcagcctgaa attttttctc ttgttcaatc tgatgaattt tcatcacaaa 2551861 cggctctatg tttttcattt gccaataagc ctttaataat tgtgtacatt cctctttttc 2551921 atgctgtctt ttcccagttt gataaccgtt cagcaccttg tacatggctg ccggatatgc 2551981 catatagctg agaaaaaggc tgacttccgc ttcacgcaaa gggaatgatt tcgtatatcc 2552041 ataaaaccat tcgacgcatt ccggacaagc tttcggaaag cctctgaaca tttttgtata 2552101 aaagccgagc aggtcgtttt gcggcggacc gacagatgct ctttcgaagt ttgtaaaata 2552161 tccggtcccg gcatcattat acagaaaatg gtgtatagac aggctgccgt ggttcattac 2552221 aacccttgaa acgtcctttt cctttgcgga ctcataccag tcctccagcc gttccagcgc 2552281 aaagttcacc gcggaaatgg tttcagaaaa ataggttatg gcctggagtt caaagggaga 2552341 aaggtaccat tccttctccg ctctatccac aaactgctca tagaaaattt tatcttgttc 2552401 ccactttttt ttcgtttgcc cgtaataacg ttcaatctca tcacgtctaa cctttagttc 2552461 ctgcgcggtt ctctcgtgaa gacgggctgt ttctctaaat aaataagcat gtttttgatc 2552521 ccgttcttcc tcttggtcaa attggagcca aggcattaaa tagtagatat ctccgtattg 2552581 tatgcctgct gagaaaaact caccgctatt tgttctgtaa acgggaacga atgaacgaaa 2552641 gcctttttcc tcaatcgcca ccatatgatc tgtaaaatgc ttgccgcgac cttctttcaa 2552701 ttttttcagg gcaaatatgc cgtagtctgt atacactttc caaacaagag gactgacagg 2552761 ctcaataaat tgagcagtca gtccgtattc ctgaagaacc gattgggtat cttccatttc 2552821 attcaccaca ttttccgatc acttacggtt tacgcatggc tatttttata ttgaggaata 2552881 tagagaatct gtcctgcttt taattcatca tccaaggcta aagaattcat cctgatcagc 2552941 tgctgggatg taatttcata ccgttcgcat aaacgctcga tcgtatcttc ctgctgcaca 2553001 atacaaattt tcattctcga aaactcatcc gcttcttttg taaagagttt tgttaaataa 2553061 agagaattat cactttcctt tgtttgaggt tccttcgttt cagcagcagg agcaacccta 2553121 ggaacagcat ccgtttcctt cctttcagtc tcagaagatt caggcagctg gaaggattga 2553181 aaaggtgttt cttccttagg ctcttcagct gatggtgttt ttctcacttc aatttcgaag 2553241 ctctcttcct cttgttcttc ctcctccagc agcttaggcg ctgaataaaa agaatcctcc 2553301 tcttcttgtt caggcaggaa ggtacggtat gccggttcag gcaattcttc ttgagatgcc 2553361 tcctccgagc ttgttttttg attgaaatgg aaatgtaaat cggcattgtc attctccata 2553421 tatacagctg aagctgtttc tctgctatct tctatggaga gagcggcctc tgatacactc 2553481 tccaaagctt catccggttc cgcctcttct tggcaaagcg caggatcagc ctgatccgat 2553541 tgagctgctt cttcattttg agcctcttgg cgcagcgcat attcatgatt aggagacact 2553601 gttgtttcct ctttttcctt tgcaatcaca gtctctgaat gaagctcagc ttccaaagca 2553661 ggcgattctt ctgctccaac gtgttcacga agctcagtct ccgctggaga gtctgcttct 2553721 tcacgaacat ccgctattgc agctgccggc tctgccgttt ctttttttgc tttaacgatc 2553781 tcttgaatct ctatttctga aggatcaggt tctggctcag attcttctgt ttccgattca 2553841 gcacgaacct ccgtttccgg cacagcaagc tcttctgact cttcttcctc tttcacatct 2553901 tctctggcct ctggttctga agcaaccgat tcaggcggct cagattctgc tttttctgtc 2553961 tccagttctt cacggagccc cgctttcgag ataaaaagtt ctggcggttc ggctggcggt 2554021 tcatgctgaa gaactgcttc ctctgccgat gatgcacccg gttcttctac tacactatgt 2554081 gccggcggct ctgaaagctc ttcctccctg aatgccgcag gagcttcata taaaggtatc 2554141 tccggctctt tgtcttgcgt atcgtccaaa agcccttcga tcgctaaatc agcttgaatt 2554201 gttaaaatgc gcgaatccgt caattgatag tcaaatgcgt caataaagac gaagacatcc 2554261 tgtaaatggc tcactttatt tttcggaatg gtaatatcca caggaaaaca gtgagtcagt 2554321 tccgcacttc catcctctct ctttctgact tgttcaacaa accgcttatc tgtataaatc 2554381 tcttcggtat gtttgttttg atctatgttg tactcacctg taagttcaag cgatcctatg 2554441 attgatacat aatcatttac ttcctgaacc ctaatatcag gatctaatga aatagaaagc 2554501 agttcagaaa cttcctgtcc tttttggaaa cagatcgatt cttctacaga aaattgcaat 2554561 cgatgatttt gcggcaagtt catatcctcc tttcatctaa tccttaaaat tagatgtcac 2554621 taaaggtgta tgtatgaact ggagaaaata tgagtgggag agcacgaaaa aaccggcaca 2554681 aggagtcctt gataccggtt ttcactctta tctgcggctg atctcagcaa atactttctc 2554741 agctgcctgg attgtgtttt caatatcttc atcagtatgg gccgttgaga ggaaaagacc 2554801 ttcgaattgt gatggcggaa ggaatacccc ttcatttgcc atccctttat aatagcttgc 2554861 gaacagcttc aaatcagatg atttcgctgt ttcataattg atgactggtt cgtttgtaaa 2554921 gaagaaaccg atcatcgaac ctgcacggtt aaaggtatgc ggaatgccat gagccccggc 2554981 ggtttttgaa attccttctt ccagtctgtc gccttttttg atgaaattct tgtaggattc 2555041 aggtgtcagc tgtttcaatg tctctaagcc agccgtcatc gcaagcgggt tgcctgacaa 2555101 tgtaccagct tgatagatcg gaccgcttgg agcgatctgc tccatgattt ctgcctttcc 2555161 gccataagcg ccgacaggaa gtccgccccc gattactttt cctaaacaag tcagatcagg 2555221 cgttacgccg aagtagcctt gagcgcagtt ataatcgacc cggaagccag tcatcacttc 2555281 atcaaaaatc agcagggagc cgtactgctc agtgatatca cgcagaccct gaaggaaacc 2555341 ttcttgcggc ggaacaacac ccatatttcc ggcaactggc tctacaatga ctcccgcaat 2555401 gtcttcaccg aattgctgga aagcaagctt tacactttct aaatcattgt acggaacggt 2555461 gatggtgttt ttcgcaatgc cttcaggcac ccccgggctg tcaggcagac cgagagtggc 2555521 aacacctgaa ccagctttaa tcaagagaga atcgccgtgt ccgtggtagc agccctcaaa 2555581 ttttaaaatc ttgttgcggc ccgtatagcc ccttgccaaa cggagggcac tcattgtagc 2555641 ctctgttccg gagcttacca ttcgtacaat ttctacagat ggcacacgat caatgacgag 2555701 cttagccagt tcattttcta cttcagtcgg agcaccaaag cttgtcccgt attcagccac 2555761 ttttttgagg ctttctacga cgcggtcatt tgtatgccct aaaattaaag gcccccatga 2555821 caagacgtag tcaatatatt cattcccgtc aatatcaaag attttcgagc cttttccgcg 2555881 ctccataaaa atcgggtcca tgtctaccga tttaaatgcg cgaacgggac tgttcacacc 2555941 gcccggcatg agtttttgcg cttctttaaa agccgttttt gatttttcat agcttctcat 2556001 ctgcctcaac tcctgtcaac tgaataaaat tactccgcaa gccatttcgc tgcgtctttc 2556061 gcatgatacg taataatcag gtcggcaccc gcgcgcttca tgcttgtcaa aatttccaac 2556121 acaatttctt tttctttgat ccagccgttc tgcgctgcag ccttcaccat tgaatactct 2556181 ccgcttacat tataagcgac gagcggcaaa gtaaactcat tttttacgtc acgcatgata 2556241 tccatataag aaagcgaagg tttgacaatc aaaaagtccg cgccttcctc aacatctgat 2556301 tgtgcttcgc ggagtgcctc catacggttg gcagggtcca tctgatatgt tttgcggtct 2556361 ccgaattgcg gtgtgctgtt tgctgcatca cggaacggac cgtaaaactc acttgaatat 2556421 ttaacagcgt aagacatgat gggaatattg acgaatcctt ctttatcaag tgcttctctg 2556481 atcactgtaa caaatccgtc catcatgttt gatggcgcaa tgatatccgc acctgctttc 2556541 gcttggctga cagctgtctg cgccaaaagc tccagcgatt catcattgag aatgactccg 2556601 tctttgacaa gtccgcaatg gccgtggtct gtatattcgc acaggcacgt gtcagcgaca 2556661 acaaccattt cagggaagtg ttctttaatt tctgtgatgg ctttttggac aattccgtga 2556721 tcatggtacg cttgtgttcc gcaatcatct ttttcttccg ggatgccgaa cacgataaca 2556781 gattgaatgc ccagtttgac cagctccgct acttcatcct tcaataaatc taatgataca 2556841 tggtgaacat caggcattga cggaacagct tttttgcctt ccagcccttc aacgacaaaa 2556901 atcggatata taaaatctga tggatgcaaa cgtgtttcct ttaccatttc tctcattgct 2556961 tttgatgtcc gcaggcggcg gtgtctatta aatgattgac tcatattctc tcttcctctc 2557021 ttgacatgct gcacattaac tcaagcatgc catctattgt aaatgtatca ggcgtatgcg 2557081 atgtgatgcc gtacgtcaga agggcatcat ttgttaaagg cccaatgctg atacaggccg 2557141 tcccattcgc cttccacttt tttaattctt ctcccaagac atgcataaac gtatgtacgg 2557201 ttgatgaact cgtaaatgtt acatagtcaa aggaatattg acccgcagcg tctttcaatg 2557261 cctcaatgcc ttcttcatcc ggaatcgttt cgtagagaac ccattccttt acttcaaaac 2557321 cgagcgggac aagctcttgt tttatcacat cacgtgacaa attccctttc atcacggtaa 2557381 tggtctcccc cggttcagca tgctgcttaa gagcgtcagc caattgttca gcaatatact 2557441 cctgtggcat cacatcaacc gatacgttat gcatttttaa acggcgcgcg gttttttcac 2557501 cgacggctgc aattttttta tgcgcaggga gaataagctg attttccttc agataagaaa 2557561 aaaagaagtc tgccccgttc acacttgtaa aaacaagcca gcctggcgcg gcaagatcct 2557621 ctcttacctg ttccgcaaca tcattcggca aagcgcggcg aaacgtaatc aaagaggtta 2557681 aaaccgcttt accgccaagc gcctccactt tttgctgaaa tgatgctgcc tgtgccttat 2557741 tccgggtgac aagcactgtt tttcctttca acggaaaatc attttccatc ctcgtcaagc 2557801 tcccgtttta cacgatcaat taaatctttt gctcctttgt cagccataag agcggcacag 2557861 cgctttccta cttcctccgg atcgtttccg gtgacggttt ctttaaaaat gattttgccg 2557921 tcaggtgaag cgacaagacc tgtcatttca atttcatcct gtccatttaa cacggagtag 2557981 cccgcgatcg gaacctggca gccgccctcc atcgcgttta aaaaagcacg ttccgctaag 2558041 acagtccgtt ttgtatattc atctgtaaac tgagaaaaca acgccaacag ctcttcatcc 2558101 gattctcggc actcaatcgc cagggctccc tgccccacag caggcaaaca gcgctcaggc 2558161 tcaaggaatt cggttacgac atcttgcttc caacccattc tggaaaggcc ggcagccgct 2558221 aaaataattg cgtcataatc ctctgtttcc agcttttgaa gtcttgtatc tatattacct 2558281 ctaatccatt taattgtaag gtcagggcgc tcaatcaaaa gctgcgcgct tcttcttaaa 2558341 ctgcttgtgc caatgacagc acctttcttc atttctgaaa gctttacgcg attctttgaa 2558401 ataagggcat cacgcgggtc ctcccgttca ggaatacagc cgatcacaag gccttcaggc 2558461 aaaacagcag gcatgtcctt catgctgtgc actgccatat caatctcttc gtttaaaagc 2558521 gcctgttcaa tttctttgac aaaaagccct tttccaccca cttttgagag tgtaacatcg 2558581 acaatccggt cgccctttgt cacgatctct ttaatttcaa aagcaaacga aggattgatt 2558641 tccttcagtt tttgaataac ccattttgtt tgagtcatag cgagtttgct ccgtctggaa 2558701 cctactttaa tcgttctcat catttctttc ctcccgaatc tgcttgggac atcgtttaac 2558761 tgaaccaatg gaattgcgac aggcttccaa gcaggaaata attgatcatc agcaccagaa 2558821 aacaagccgt attccacagt gcagcgacct ttccttgcag ctccttaatc agcctgatat 2558881 aaagataata gctgtacagc agcaggacga caaacgaacc aagcactttg gcgtcaaacc 2558941 aatacagcgt ttctagtgag acatacgccc aaatgacgcc gagaatcaaa ctcagcagca 2559001 gcatcggaac cccaatgaca tttaaaacat acgccatata atcaagctta gataaatctt 2559061 ctattctcaa cagccatttt ccccactttt tctttttcag cagatgatat tgaaacatat 2559121 atagcacaga aaaaacgaaa gaaagggaaa aagcgccgta tgaaagaatc gccattgtaa 2559181 tatgaatcac caaaagctcg gatacaagct gcccggaaaa agcagctgac tgctgctctg 2559241 tcggtgaaaa tgtgtgaatg gcgatcatag aaaatcctat aacatttgta aaaaacacga 2559301 taaagtcaac acgtaaaagc tttgtcagta caagtgacag cgtgacaagc acccaggcat 2559361 aaaaataaag tgcctctgtc acatttaata ccggaaaccg ccccgtcacc cacataaaat 2559421 aggccaaata cacggtttgc agagtccaga caatagaaag caaccagaag gccatttttc 2559481 cagccttccg gttgtgttga agaaaatcta taaaataaaa gagtacactt aacgcgtaaa 2559541 tgacgattgt cccctcatta agtcttgcca ttgcagtatc aatcattcag ctttcactca 2559601 cttacaagtg ggctaaagcc cgcttttgat tcagccttct taaaagagtg gaccttctgg 2559661 ctgctttcaa cggttttcat catttgacgg cccgcagctt cttcaatatc aaaaatctgc 2559721 ataaacaacg cgagcttttc ttcagaatca gcatctgccg caagctcttt cacctttaaa 2559781 atcggatcac gaagcatttg gttaataata cttttggtgt gtttgttcaa cagttttttc 2559841 tctcttgtgc ttaagtgagg cagcttacgc tcaatgctgt ccatcgtttc tgactggatg 2559901 gcaagcgcct tttcgcgcaa tgcagaaata acaggcacaa caccaagtgt attcatccat 2559961 tgtttaaatt ccacaatggt ttcttcaatt aacagttcaa ctttttcagc tgtttctctc 2560021 cgctctttca tgttcgcttc tacaatgcct tccagatcgt cgatatcata aagaaaaaca 2560081 ccttcaagat cattcagcgc cggatcaaga tctctaggca cggcaatgtc gaccataaac 2560141 agcggacgtc ccttgcgaag cttattcgcg ttttccatca tctctttgga cacgacaaat 2560201 tcacttgcac cggttgaact gattaaaata tcagcctccg caagcgcgct ttcaagctga 2560261 ttcaagcttc tcgcttcacc tgaaaaacgg tctgcaagct ccttcgcttt caagtatgtt 2560321 cggttaatga cagtgacctt gccgattccc tgtccgtgca ggttttccgc agcaagctcg 2560381 cccatttttc ccgcaccgag aatcaatatg tgcttgcttg aaagatttcc gaagattttt 2560441 ttggcaagtt caactgcagc atagcttact gacaccgcat ttgagccaat gtctgtttcg 2560501 gcgtgagtcc gtttgcccac tgtaactgcc tgcttaaaca gctcattaaa aatagtcccg 2560561 atcgtttttt cttgctgagc tgttttaaag ctgtcgcgta cctgtccgag aatctgcgtt 2560621 tcgccaatca ccatagaatc aagtccgcag gctacacgga ataaatgctc aacagcggca 2560681 tcgctctcat aaaacgttaa gaacggtgac agctcttctt tgcttaattg aaaccaatca 2560741 gctaaaaact tttttatata ataacggccg gtatgaagct ggtcgactac cgcataaatt 2560801 tcagtgcggt tgcaggttga gacaatgatg ttttcaagaa tgcttttctc ttctttcagc 2560861 tgcaccattg cttctgccag ctcattcggc tgaaaactta ctttttcacg tatctcaata 2560921 ggggcggatt tataatctac tcccacaaca agtatatgca tcgctctaat tacaccccca 2560981 acacccaatc ttaatttata atcattctaa catagaactc attatttata ataattataa 2561041 catagtttct ttcacaaaat gtgaacagat tttaaaattc ttatgctata ttagaaaaag 2561101 cttcagggaa aagaagcatt cctattgaca ataccaaaaa cagcagaaat ttactacaca 2561161 tcagctctaa aaaacaagaa ggtgatatgc atgaaacaaa aatcaatttt attcccttgt 2561221 ctgctgcttg ccgcttctgt atatgcatgg ctagaaagcg gccaagccga actgttttca 2561281 gggcaggatc aatggcctgt tctcctcatg ctgttaggcg cagcctttgt atatcaagga 2561341 aaaaaagaag ccgtcacacc ccattttttt atcggtttgc ttctcttcgg gatcggttta 2561401 cacttttttg ccaagccgaa atgggtatgg tggccggatg attttgaaat gctcctcttt 2561461 atgatcggct tctcacttct cgtttcaacc gttcaaaaaa aagaatatgt atatgaagct 2561521 gtgtcgatga tttgtttttc cctgtttttg tactttttca aacaaattat ggcatggctt 2561581 gagtctgcgc atattccaac agcgcttctg aaggagtatt ggccgtttgt ctttattgga 2561641 atcagtttat tgttattatt gataaaacga aaaaaatcta tacgataaat aaaaccggta 2561701 gaggatcctc taccggttta tcattttttt gatcgctccc caagcttcgt cttttccctt 2561761 tttcgtttct gaagaaaaga ggatcagctc gtcttccgga tcaatattta atgtttgtcg 2561821 gacaaccttc gcgtgtttgt cccatttacc tttcgggatc ttatccgcct ttgtagcgat 2561881 aacaataaca ggaatgccgt aatactttaa aaattcatac atctgtacat catcattaga 2561941 tggcgcatgc cgcaaatcaa cgatctgcac cacagctttt aattcctcgc gtgtcgtgat 2562001 ataggtttca atcattctgc cccatgcttc acgctcagac tttgacactt tggcaaaacc 2562061 gtagcccggc acatccacaa aatgcagctc atcattgata atgtagaaat taagcgtttg 2562121 tgtttttccc ggctttgatg acgttctcgc aagatttttg cgattgatta atgaattgat 2562181 aaaagacgat tttcctacgt tcgatcttcc ggccaatgcg atttccggaa gccccccttc 2562241 agggtactgt tccggtttta ctgcactgat cacgatttct gactttgtga ctttcatttc 2562301 ttctctccta ctaaggcatg ttccaaaacc tcgtctaagt gggacgccaa tataaatgtc 2562361 agcccctccc tgacgctttc cggaatatcc tctatatctt tttcattatc tttaggcgca 2562421 ataatggtcg ttaatcccgc tctatgtgcg ccaagcgctt tttcctttaa gccgccgatc 2562481 ggcagcacgc gcccgcgaag cgtgatttcc ccagtcatgc cgacttcacg cgaaaccgcc 2562541 cgtcccgtta aagcagaaac aagcgctgtt gccatcgtaa taccggctga cggaccatct 2562601 tttggcaccg caccctctgg tacatgtata tgaatatcat acttctcatg aaagtcaggt 2562661 tcaatgccaa gttcttctgt tttggatcgc acatagctga atgcagcctg agcagactct 2562721 ctcataacat ctccgagctt tcctgtcagg attaatttcc cttttcccgg tgaaagcgat 2562781 acttcaatcg aaagcgtatc tccgccaacg gttgtatacg caagccctgt cactacacca 2562841 acttgatcct ctgtttcagc ttgtccatat ctgaaaatgc gttttccgat aaaatcttga 2562901 aggttcttct cagtaaccgt aattcgtttt cgctcttcag caacaatggc ttttgcagct 2562961 ttacggcaaa ttgcggcaag ctggcgttca aggcttctta cacccgcttc tctcgtatag 2563021 taacgaataa tatcaagaat cgcctgatca cgcagctgaa gattgctttt cttcagcccg 2563081 tgttctttga tttgctttgg aagcaagtga tcctttacaa tttcaagttt ttctatttct 2563141 gtgtagcctg cgatattaat aatttccatt ctgtctctga gcgggcccgg gattgtggcc 2563201 aaattgttcg ccgttgcgat aaacagcact ttggataaat caaaggtttc ttcaatatag 2563261 tgatcactga agctgctgtt ttgctctgga tcaagcactt caagcatagc ggatgatggg 2563321 tctcctctaa aatcagatga cattttgtca atttcgtcta ataagaagac cggattcagc 2563381 ttgcccgctt ttttcatccc ttgaataata cgtccaggca ttgctccgac ataggtccgt 2563441 ctgtgtccgc gtatctctga ttcatcccga actcctccga gtgagattct gacgaatttg 2563501 cgtcccaagc tttttgcaat tgatttggct aaagacgttt ttccgacacc tggaggtcct 2563561 gccaaacaga gaatcgggcc tttcagggat tttgtcagct tctggacagc caaatattct 2563621 aaaatacgtt cttttacttt ttcaagcccg tggtgctctt cgtccaagag acgtcctgct 2563681 tctttcaaat caagcttatc atctgtttca tccgtccacg gaagagcaac cagccagtcg 2563741 atatagttgc ggatcacaga gctttccgca gaacttgacg gaattttttc atatctgttc 2563801 aattctttaa gcgctgtttc tttcacatga tcaggcatgc ctgcttcttc gattttttcc 2563861 gtcagcgtct gaacttcgcc agttttgcct tctttatcgc caagctcttt ttggatcgcc 2563921 ttcatttgtt cacgcaagta gtattccttc tgcgtacgct ccatcgaacg tttgacgcgc 2563981 tggccgattt ttttctcaat ctccagcact tctttttcat tattaataaa atcaatgacc 2564041 ttgttcagcc tgtctttgac atcagccgtt tctaaaatat cctgcttatc ctttagttta 2564101 aggggcagat gagaagcaac gatgtctgcc attctccccg gctcttcgat atcagtaacc 2564161 gcagcgtacg tttcggccga gattttttta gaaattttta tgtactgatc aaagtggtct 2564221 agcaaagtcc gcatcaatgc ttcgtcttct gtatcttttg aatcatcttc atgaataagt 2564281 tgaatgtcaa ccgacgtgta atcctcgtgt tcattgtatt tgacgatatg ggcgcgcttg 2564341 aggccctcca ccaacacacg aatcgtaccg ttcggaagct tcagcatttg cttaattttt 2564401 gtataggtgc cgacagtgaa aatctcgtct tcaccaggtt cgtctatcga aatatcctgc 2564461 tgagtggcta aaaatatcat atgatcatgc atcattgcct gttcaagagc ctgaaccgac 2564521 ttgtcacgtc ctacatctaa atgcaaaacc atcgtcgggt acactaataa acctcttaaa 2564581 gggaggagcg ggatgctgcg ttttaattct tctgccatgt gactgacacc tccgtgactt 2564641 tagtatgaac cattataata caactttttc atccttgtac aataaacggc atggttccat 2564701 tttctataaa acagtctcct cgtagtatac cctttctttc tgatatgaaa aaggaaaaga 2564761 tgtccttcat gaaaaaaacc ctattatcaa aatagggttt aaacggattc tttattgatt 2564821 tcgatatgaa acggtttttg ttccgttggc ggattcacca aaatttcatc aagcacttct 2564881 tggaacgtct tcactgcaat aatctcgatc ccgtcaatct gctttaagat ggcctgctga 2564941 ttttcatatg ggataatcac ctttttcgca ccggactgct tggccgcttt tattttcgga 2565001 atgacgcctc cgatgggttt cacaagaccg ttcaggctga tttcgcccgt catcgcaacg 2565061 gtattgtcaa taggaatttt gtgtatcgcc gagaaaatcc ccgccgccat cgcaatgcct 2565121 gctgacggcc catcaatcgg aatccctcct gggaaattga tgtgaatatc ataatcagaa 2565181 ggcttcattc ccattgtccg gagcacggtt aatacatttt caaccgaacc cttcgccatg 2565241 ctttttcgcc tgatcgattt tgattggctg ccgatgcttt cttcttcagc tattcctgtg 2565301 atgttaattg atcctttatc ttgagccgcg gttacactta cttcgatttc cagaagcgat 2565361 ccgctgttag gcccatagac tgcaagccca tttacaatgc caacctgtgg ttcaacaccg 2565421 attttttgct cgtgctttgg agtaagctga ctggagtgaa tgacccattc aatatcctca 2565481 atcgtaatgt cctttcgatt ctccgttaca gccatccccg ctgcgatttg aatcatattg 2565541 acggcttccc gcccgttccg cgtgtagctg gtcaaaagat ccagtccttc ttcggagata 2565601 tttttttcaa ttttatccgc tgctgttttg gcaaccgttt tcagctcgtc cttttcaagc 2565661 tcgcggaaaa aaacctccaa acagcgggac cggatagctg gcggaatttc gtttggcatt 2565721 ctcgtggtcg cgccaatcaa gcgaaaatca gccggcagcc cattttgaaa aatatcatga 2565781 atatgattcg gaatttgtgt attttcctca ctgtaatacg cactgtctaa aaagactttt 2565841 ctgtcctcaa gcaccttcag cattttattc atttgaatag gatgcagctc ccctatttca 2565901 tcaataaaca gcacaccgcc atgggcatgg gtgacagctc cctgcttcgg ctgcggaatc 2565961 ccagcctgtc ccatcgctcc ggccccttgg tatatcgggt catggacaga gccgatgagc 2566021 ggatcggcaa ttcctctttc atcaaaacgg gctgttgtcg catcgagttc cacaaagaca 2566081 gcctgctctt taaacggtga ttgtttatgt ttttttgctt cttccaacac aagccgcgca 2566141 gcagccgttt tcccaactcc cggtggccca tagacaatca catgctgagg atttggcccg 2566201 cataaagccg cctttaatgc tttaatgccg tcttcctgtc cgacgatatc tttaaagctt 2566261 ttggggcgga ccttctcaga taatggctcg gacaagctga tagcgcgcat tttccgaagc 2566321 tgctccattt ccttctttga ttctttatct atcgtgacct tttgtgtcct ttgattttta 2566381 agcaaattcc aaaaatacaa accgatgatg atcccaaaaa acagctgaat aaataacgcg 2566441 atccctgtcc aactcatggt ggtccctcct gaaaaacaat ttatgtatcc aattcattcc 2566501 tctgattgct agtatctccc atagaagacg ggaataaacg tttttccgga agagttgcat 2566561 gcaaaaaaac ctcctgagtg ttaccactca ggaggtttgt gcttatcttt atgcagatgt 2566621 tttatcttgg cttacctcag tgccgtcttt taataagagg cgaggaggct ctccgtgtgt 2566681 cacagttgcc ccggtgatta cacatttttc aatgtcatca cgagaaggca gctcaaacat 2566741 cacatcaagc atgatgcctt caatgataga acggagtccg cgtgctccag tcttgcgttc 2566801 aattgctttt ttagcaattt cagaaagcgc ttcttcttca aactcaagct caacgttgtc 2566861 aagctcaagc attttcttga attgcttaac aagagcgttt ttcggttttg ttaagatcgc 2566921 aaccaatgct tcttcgtcaa gcttttcaag gcttgcaata accggaagac gtccgataaa 2566981 ttcaggaatt aacccgaaac ggagcaaatc ttctggaagc acttttgaaa gaagatcttc 2567041 tttctcaaga tcagcagctt tattgtcggc accgaatcca atcacttttt ggcctaaacg 2567101 gcgtttgatg atttgttcga taccatcgaa agctccgccg caaatgaaca aaatatttgt 2567161 tgtgtcaatt tgaatgaatt cttgatgagg atgcttacgt ccaccttgag gcggtacgct 2567221 tgccactgta ccctcaagaa ttttaagcaa tgcctgctgt acaccctcac ctgacacatc 2567281 acgtgtgata gacgggtttt cagattttct agccacttta tcgatttcat caatatagat 2567341 aatgcctttt tcggcttttt ccacatcata atcagcagct tggatgagct tcaagagaat 2567401 attctctaca tcttcaccca cgtatccagc ttcagtcaaa gatgtagcgt ccgcaatcgc 2567461 aaacggcaca tttaaaatgc gagccaatgt ttgcgccaga agggttttac cgcttcccgt 2567521 agggccgatt aatgaaatat tactttttga aagctcaaca tcatcaactt tgctgttgga 2567581 gttaatgcgc ttatagtggt tatacacagc aacagcaagt gatttcttcg cttgatcttg 2567641 gccgatgaca tattcattca aaatttcgcg aatttcctga ggctttggta cgtctttaaa 2567701 ttctacttct tcttctgttc cgagttcttc ctctacaatt tcagtgcaga gttcgataca 2567761 ttcgtcacat atatatacac caggtccagc tacaagctta cgaacctgat cttgtgtttt 2567821 tccacagaac gagcatttta attgtccttt ttcctcgtta aatttaaaca ttctttcacc 2567881 ccttaatctt gtctcacttt ttcttttacc ggcagagcaa aagaaaatga ttcttgaaac 2567941 gaacgagtat gtattgcatt ttaccatact ttccaaaaag acggtaacaa tgtgtttctg 2568001 acttgcacat tctatatgta tgacaaaaaa cagccctgca ttaactatat tgccccaaga 2568061 aaaagagata actcataatt gtacaaaaca aggcacgaat gattcgcgcc ctgttttatt 2568121 agtactatta ttatgcacca tattaacggt tttctacaag aaaatcaatt gctttgcgaa 2568181 cttttaaatc ttctttcatc gcgtcagtag aaccgatggc ttgtttaata ttttcaacag 2568241 gcatgttgta tgcttcagcc atttttgtaa gctcagcatc aacttcctca tctgatactt 2568301 caaggttttc cgctttcgca atcgcctcaa gagtcaggtt agattttacg cgtttttcag 2568361 catcttcttt catttgctct ttaagcgcag cttcatcttg gcctgagaat tgagtgtaaa 2568421 gctcaaggtt catgccttgc atttgcagac gctgttcgaa ttctttcagc atgcggtcaa 2568481 gctcagtgtc gaccattgct tgaggcacat cgatttcagc attttcagaa gctttcagaa 2568541 caagctcttc acgcaattta gcgtcagctt cgttttcttt tgcttcttct aaacgtttct 2568601 ttgttttttc agttaattca gcaagtgttt ccacttcttc atcgatatct tttgcgaatt 2568661 catcgtcaag ctcaggaagc tctttcgctt tgatttcgtg aattttcact ttaaacacag 2568721 ctggtttgcc tgcaagatct tcagcgtggt actcctcagg gaatgtcact tcaacatcct 2568781 tctcagcacc tgcttcaagg ccaactaatt gatcttcgaa gccagggatg aatgaaccag 2568841 aacctacttc tagagagtag ttttcagctt ttccgccttc gaaagcttcg ccgtcaacga 2568901 atccttcgaa atcaagaaca actgtgtttc cttcttcaac ggcgccttct tcttttacaa 2568961 caagctcagc ttgacgctct tgaagggctt ttagttcgtt ttgaacatct tcgtcagtta 2569021 cagttgtgtc gtctttttca atgcccaggc ctttgtattc gccaagcttc acttcaggtt 2569081 ttactgttac tttcgcagtg aagattaagc tttcgccttt ttcgattttt tcaacatcga 2569141 tttcaggacg gtctacaggc tcgattccag cttcttcaac cgctttaggg tattctacag 2569201 gaagaagaat atccaaagca tcttggtaaa gagcttctac gccaaagcgc tgttcgaata 2569261 atccgcgagg aattttacct ttacggaatc caggaattga aacttgtttt actacttttt 2569321 taaatgcatc atcaagtgct gttttaaacg tttcagcatc aacttcaacc gttaaaacgc 2569381 cttcgttgcc ttcttgtttt tcccatttta cagacatgtg tttccctcca aaaatctatt 2569441 caggttgtgt cggtcttcca ttctaaagca atcattcggc ttcgtccaac aaaaacaaag 2569501 ctgccaaaga tcagaatcat tatgtataga tgttaataat gaactgcaaa gcctgtccaa 2569561 ccgtatttct tataacccgt tatacacaaa tacaaccact atattataac ataacacata 2569621 gcgctttcaa ctatatggcg cgatttacaa ataagaaatt tcttcaatat cttttaacat 2569681 tgtgcaagct tcatcgagtt ctctgtctgt aaattcatac atcatatgaa gttcttcgct 2569741 ttcaatttca atcccgtgca tctcgtaacc gactttatga agggcagccg cccaaaggtc 2569801 agccgacagc aatttcggct ggaacggata taaaacgtac aaatgtcttc tccacaattc 2569861 ttctactgct gcatataagg ttggattttc atttccaagt gtctcatcta gcaccctgag 2569921 aacacggtga agaatcggcg cggcatcagg cggaacaatc tctgacggtt caattgtcaa 2569981 cgactcgcca aatttactaa tgtgtacagg tttactgtac tcatgctcag ccaacagcat 2570041 gacaatcatc gttttgataa tcggatgggc tgaggggtct tggaggattg ttttgagcaa 2570101 tcctgtatac tttgctacgt tacggtcttt taaggaatga atgagattca tttgctcctc 2570161 agggcttgcc agcactttct cggtgtcaat tgtatcctca tattcttcgg cccaagcctc 2570221 gtcctcacga tccggatcgg tcattttccg gctgaaatcc agcagcttat aaaattgctc 2570281 ggcactttct gccggcagct gattttcttc caaaacggct tcaatggtgc ttttgacttc 2570341 ttcgtacttt ttgagctgaa ttaagatggt catgtacacc tgcaaaaccg taaaataatg 2570401 gccataacct tctttgagca tcttctcgca cacgctttct gcctcttcca gctcgcccag 2570461 ctctaaaaag cagatggcca tccctaagtg aagatcggat tcagtatcat catatttcat 2570521 cgcttctgaa aacagttcaa gcgcttcttg atactttttt tccttgagtg atgacatccc 2570581 tttttccaca aggcggtctt tcagatgagg aaaaggaata atttttgcgt ttttcttgtc 2570641 atgcgtcata cctatattcc tttcaggcat ttattttgtt caagtgtatc aacacctgtg 2570701 aacaaaaaca agaaatgaaa ggtttcacca ggcaaaaaaa gccgccggac aaataccggc 2570761 cgctttttca ggcttgaagc caagagcttc tttgtgattc aaattgcttg atttcatctt 2570821 ccagcagcag cgttaatgaa atttcatcat atccgttgat cagcatctct ttccaatgcg 2570881 gatcaacttc aaatgaaatt tgattgcctt cactgtcatg aatcagctga ttttcaaggt 2570941 caacagtcat ttgcaatgac tggttttcat actggccgac aagctgtttc caattgtcat 2571001 atggcatgcg gatcggaagc atgccgtttt taaagcagtt ctgatggaaa atatcagcga 2571061 atgacggcgc aatgataatt ttaaacccat aatcatcaag tgcccacgga gcgtgttcac 2571121 gcgatgaccc gcagccgaag ttttctcctg ctattaaaat ggaagctcct tgataaacag 2571181 gctggtttaa ttcaaattca gggttcggtt caccattcgc atcatatctc cagtcaaaga 2571241 atgcaaaacg tccgtagcct gttctttcaa tcctcttcaa aaattgctta ggaataatct 2571301 ggtctgtatc cacattgatc cgatttaata cggctgcttt ccccgtatgt gatttcaaag 2571361 gttccatctc gcgcactcct tacacaactg ttttttcctg ataaaacttt ctgacatcaa 2571421 cgaagtgtcc gtgaatggca gccatcgcag ccattgccgg gctgacgaga tgtgttcttg 2571481 caccttttcc ttgtctgccc tcgaagttgc ggttagaggt tgatgcacag cgctctccct 2571541 caggaacaac atcattattc atactcaaac acatgctgca gcctgactct ctccattcaa 2571601 atccagcttc caagaaaatc tggtcaagcc cttctttttc agcctgaagc ttcacgcttt 2571661 gggatccggg cacgacgatg gcccttacgc tgtcagctac cttcttccct ttgatcatgt 2571721 cagcagcctg tcgaaggtca gtcatgcggg aatttgtgca ggaaccgata aatacgtgct 2571781 ccactttaat gtcttcaatt ttttggtgag gagtcaatcc catatattca taagcacgaa 2571841 tcgcttcttt tttatcgtct tctgcagaaa agctttccgg cgcaggaact tcagaatcga 2571901 caggaagaac cattcccggg ttaatgcccc atgtcaccat aggggaaatt ttgttgccgt 2571961 caaggacgat agatttatcg taaacagcgc ccgggtctgt gcgcagcgcc ttccattcct 2572021 ctacggcctt gtcaaattct tcgccttttg gcgtgtactt gcgatttttg caatattcaa 2572081 acgtcacctc gtcaggtgca atcaaacctg ctcttgctcc tgcttcaatt gacatgttac 2572141 aaacagtcat tcgttcatcc atcgtcatat ttctgaatac ttccccagtg tattcaatga 2572201 cgtagcctgt gccgaatttc acaccgtatt tgccgatgac agcaaggatg acatcctttg 2572261 ccgttacccc tttttgaagc gttccatcta cgcgcacttc aagtgttttt ggacgctgct 2572321 gccaaagtgt ctgtgtggaa aggacatgtt caacttcact cgtcccgatt ccaaatgcaa 2572381 gagcgccgaa agcgccatgt gttgatgtat gactgtcacc gcacacaatc gttttccctg 2572441 gaagcgttaa gcctagttca ggtccgacga catggacaat cccttgatcc acactgtgaa 2572501 gatcggcaag gcgcacgcca aattcctcac agtttctttc aagcgccgtt acctggcgtt 2572561 tcgcaacttc atcctttatc tcaaaacgat tgacagtcgg gatgttgtgg tccattgtcg 2572621 caaatgtgtt ttggggtctt ctgacctttc ttcccttttg tctcaagcct tcaaatgcct 2572681 gaggagacgt cacctcatga atgaggtgca aatcaatata gagaagatcc ggctttccct 2572741 caccatgttt tacaatatgc tgatcccaaa tcttttcgat gattgttcga ggcatcatct 2572801 tttatttcct ccctctacct agagctaaga ccgcttaacg taagctgtca cacattagaa 2572861 attgtatttt cactcatgat tgctgcctta acttcctctg taatggcctg agtgctgctg 2572921 aactcttcac tccgtgccaa gtctcttgtt ctttttccag aagccaagac tttgtttacc 2572981 gcatcttcta cagctttcgc ttcctcttca agcccgaaag atgttctcaa aagcattgcc 2573041 gctgacaata tggctgcgaa cggatttgcc atccctttac cggcaatatc aggcgcggag 2573101 ccatgaacag gttcaaacag atgaaggcca gagcttgata ggctggctga cgggagcatt 2573161 ccgagcgagc ctgtaagcat ggacgcttca tcgcttaaaa tatcaccgaa catattttca 2573221 gtcaccacga catcaaattg attcggtgca taaattagct gcatggccgc gttatccaca 2573281 agcatgtgct caagcttcac atcaggaaat tcttgtgcaa cgtcctcagc cacttcacgc 2573341 cacagccggc ttgattcaag aacattcgct ttatctacag aggtcacttt gccttttctg 2573401 gctgccgcca ttttgaagcc ctctctgatc actcgttcaa tttccgttcg cttataaaac 2573461 agtgtatcta ctgcttcctg ctcaccttca gtgtttacat aacgtttgct cggctggccg 2573521 aaatacaagc cgcctgtgag ctcacgaacg ataacgaaat caacattatc tatatattct 2573581 tttttcaaag gcgaagcgtc agaaaggctt tcaaatacct tcacaggccg caaattcgca 2573641 aacaaatcaa gctgttttct gatgctgagc agcccttttt ccggtctcag ttccgaagga 2573701 ttttgatccc atttcggtcc gccgacagca ccaagcaata tcgcgtctgc atttttacaa 2573761 gcagcaacgg tttcctccgg gagggggtta tgatgttcat caatagccgc ccctccaatc 2573821 aggccatatt caaattcaaa ttcatggtta aagcgttcgg caacactttt cagtacgtct 2573881 gtcgctgatt ctaatacttc agggccgatc ccgtctccgg gcaatagagc aatacgtttc 2573941 ttcaagttaa ccgttctcct ttcttttatg atccgacagc tgtgtggttt ttcaatccgc 2574001 tcatattcga ctggaaaacc aattgacggt ttactgcgtt caaataggct ttcgctgatg 2574061 cttctaatac gtcttgcgct atgccccgcc ctgctgattc ttttccgttc accaaaactc 2574121 ttacatacac ctgggcaaat gcatcttcgc cttttctatt agactgaatg cggtagtcta 2574181 agagctccac atccttatcg atgcagcgct caagcgtatt gtagattgct tccacgcttc 2574241 cagctccagt tgcagcttcc tgaataagct gtgcgttttc ttgatttttc aaagatagag 2574301 tagccgtagg gacctgactt gttccgtaat gtacttgcag agaaagaaat tcatacccaa 2574361 tcttgcgatc tgttactttt tcttctaaaa taagagaaac aagatcctca tcagtgattt 2574421 cttttttctt ctcagtcaac tctttgaaca tcgtaaagaa tttattaatc tcttcactgt 2574481 caaattggaa tcctaaagca gtcagccggt ctttaaatgc gtggcgtccg gaatgtttac 2574541 ctaggacaag cgcatctgcg gttacgccga caagctccgg tgaaataatt tcataagtcg 2574601 atttttcctt taaaaagccg tcctgatgga tgcctgattc atgagcaaat gcattatctc 2574661 caacaaccgc tttgttgcgc gggacagcca tgcctgtcag tttgcttact aaatcacttg 2574721 ttctcttaat ctcgttcagc gtaatacctg tttcgacttg gtagaaatct tttctggtat 2574781 ggagggctac ggcaatttcc tctaatgccg cgtttccggc tctttcaccg atcccgttca 2574841 cagcgcattc gatttgatca gcgccatttt caatcgcagc aagagagttt gcgactgcca 2574901 ttcccaaatc atcatgacag tgggctgaaa gctttgcttt gtgaatgttc ggaacgtttt 2574961 ctttcatata tttaaagata tttccgtatt ccgccggggc caggtagccg acagtgtccg 2575021 gaagattgat aacactggcg cctgcgtcaa tcactttctc gacgatttct gctagaaacg 2575081 gcagttcagt gcggcaggca tcttcagctg accattgcac aatcggaaaa cgttcttttg 2575141 cgtatttcac cattccaact gctctttcaa tgacttgttc acgtgtcatt ttcagcttgt 2575201 gcttcaaatg aatgtccgat gtcgcgataa atacatgaat tcttggttga gcgccatcct 2575261 ttaacgcttc ccaagcagca tcaatatcac cttttacaca acgggccaga ccagttactg 2575321 aacaattttt aatggttctt gcgatttcct gaacagctaa aaagtcacct cgggacgaag 2575381 cgggaaatcc cgcttcaatg atgtctgccc cgagtctttc gagctgctta gctatggcaa 2575441 gtttctcctg tgtattcaag ttcactccag gggactgttc accatcacga agcgtcgtat 2575501 cgaaaaaatt aattttgcgc aacggagacc accgcttcct tcttcttgcc ttgtttcaca 2575561 aacggcatca tttcacgaag ctttcttccc actacttcga tttgatgttc gttctcgctt 2575621 gcattgatag cgttgaaacg aggacggttt acttggtttt cgacgatcca ctcttttgcg 2575681 aatgtaccgt tttggatatc ttttaatact tctttcatag attcttttac tttggcgtcc 2575741 acaacgcgag ggcctgatac gaaatctccc cactgtgctg tgtcagagat tgaatatctc 2575801 attcctgcaa gtccttcttc gtacataagg tctacgatta atttcagctc atgaagacac 2575861 tcgaagtatg caagttcagg ctgataacct gcttcagtta aggtttcaaa tccggctttg 2575921 acaagcgcgc ttaatccgcc gcaaagaact gcttgctcac cgaacaaatc tgtttctgtt 2575981 tcttctttaa atgtcgtttc taatacgccc gctcttgcgc cgccgattcc tttagcataa 2576041 gcgagggctt tgtctcttgc ttctccagtc acatcttgat agattgcgaa caatgcaggt 2576101 acgccagctc cttgctcata tgttcttctt accaagtgtc ccgggccttt aggggccact 2576161 aagaatacat ctacatccgc cggaggaaca atttgatgga aatgcacgtt aaatccatga 2576221 gcgaatacta atgattttcc tgctgtcaat tcatctttga tttcagcttc gtatactttt 2576281 tgctgctgct catccggaag cagaaccatg atgatttcgg cttgggctgc cgcttctttt 2576341 actgaaaata ctttatgtcc gtcttcttgg gcttgagtga aagattttcc ttgtctaaca 2576401 ccgacgatca cgtctactcc gctttcttta aggttcaggg catgtgcgtg gccttgcgaa 2576461 ccgtacccga taaccgctac tgtttttcca gccaatacgt tctctttgat atcaccgtta 2576521 taatatactt ttaccatttc aatctctccc ttgttatgtt ttatacaata gatattgttt 2576581 tattggatga cgccttttgc tgggttcccc tcgcaaaagc cgttgtacct gttctcgcga 2576641 tttctttaat gccataaggt tttaataact caataagcgc ttcaattttg ttagattcac 2576701 ctgtcacctg aacaacgatg ctgtctctgc tgacatcaac gacagaggct ctaaacggtt 2576761 ctatgattcc attaatctct gttcttgttg aaggtgcgga gacaaccttg attaaggcca 2576821 gctccctctg gacaatcgat tgatttgtga tgtctgtgac tttcagcaca tcaatctgtt 2576881 tgttgagctg tttcgttaac tgttcaacat cattttcacc ttcaacatga acgacgaagg 2576941 tgattctgga aacgccggct gtttctgtgt gtccaactgt aatgctttca atgttgtaat 2577001 gcctttttgt gaatagaccg gtgatccggt ttaacacccc ggagcggttc accacagtca 2577061 atgtgataat tcttttcaag gtttcacccc caccatttca tgcagccctt tccccggagc 2577121 caccatcggg aatacttttt cttcgctggc aacccgcacg tcaatgacaa caggttctct 2577181 tgatgttaat gcctcttcca gcttttcctt tgcttccgct tctgatgaaa ttctgatgcc 2577241 tttaatgccg tatgcttcgg acaatttgac gaagtcaggc tgagaagcga atttagattc 2577301 tgaataacgt tcttcataga aaatttcctg ccactgtctg accattccga gacaagcgtt 2577361 atttaaaatc actaccttga ccggaagatt taattcgcga ataacatcga gttcttgaag 2577421 cgtcatttgg aatccgccgt ctccgacaac cgcgacaaca gtagcatctt tttcggccag 2577481 ctgtgcgccg atcgccgccg gaagaccgaa tcccatcgtt ccaagtccgc ctgacgtgac 2577541 ccatttatct gctttttgga acggataaaa ttgcgctgac cacatttgat gctggcctac 2577601 atccgttgcg acaatggcct ctccttttgt aaattgatga atatattcaa tcaatttctg 2577661 aggtttaaaa ccttcttctt cattatctac ataccagagc ggatactctt ctttccattc 2577721 tgcgagctgt tttttccatt cgcttgaatc gctttgtttg ccgtcttgtt tgatcagctc 2577781 ctgcaggaca attttgctgt ctccgactac aggaatctgt gttttcatga tttttccgat 2577841 ttcagctgga tcaatatcga tgtgggctat ctttgcgttt ctggcaaagt gtttcaggtt 2577901 tcctgtgaca cggtcatcaa aacgggcgcc gatactgatt aatagatcac attcatgaag 2577961 ggccatattg gctgtataag taccgtgcat tcccgccatc cctaggaaaa gcggatggtc 2578021 agccgggaag cctccgagcc ccaaaagggt gtgtgccaca gggatttgct gctgttcagc 2578081 ataatttttt aattcttctg acgcttttcc gtgcagtacg cccgcacccg ccaggatcac 2578141 cggttttttc gcactgctca cggcttccac aagcttgcgg atctgcaaat aattcggctc 2578201 tgttgtcggc tggtatcccg ggagattcat ctcatgatcg tagctgaatt ctccttcaat 2578261 tgttgctaca tctttcggaa tatcaatcaa tacaggtccg ggtcttccag ttgttgcaat 2578321 atggaacgct tctttaatga tgcgcggcag atcttccggc tggcgaacct ggtagctgtg 2578381 ttttgttact ggcatcgtaa tccctaaaat gtctgcttcc tgaaatgcat cgctcccgat 2578441 tacagaggtt gctacctgcc ctgtaaagac gactaacggc aatgaatcaa tcatggcatc 2578501 agcaaggcct gtaacaaggt ttgtcgctcc cggccctgac gtggcaatga cgacacccgg 2578561 ttttccggag acccttgcgt atccctccgc tgcatgaatt gctccttgtt cgtgacgggg 2578621 aaggatatgt accaaccctg aattgtatag cttatcgtaa atcggaagca cagccccgcc 2578681 cggataaccg aagatcattt ctactttctc tttttttaat gattcaatca gcattaatgc 2578741 tccgctcatc gtctgtgtac attcggcaga tgctgaatcc acctgtacat tagtccccat 2578801 tttagttcct ccttttggat tttcatcctt taaagatcat cttttcatta gctagatagc 2578861 tgattattca ataaaaaaag cccttccgcc cacaatcagc cgcgcagtaa ctgcgatagc 2578921 taaaaggggc gaaaaggctt ttctttccgc ggtaccaccc ttgtttacgg cctgttaatc 2578981 ggccgtctca tggatatttc tatccgcttt agtaacgagt gaatcaagtt cacccggcca 2579041 agtcctactg tcatttcaga ctggcactct gaggcgagtt caccttgtaa agcttcgccg 2579101 gttctcagct aacccggttc tctgtggaaa actttatcaa ggctacttat cctcatctgc 2579161 gcttttcata ttcagccttc ggaacggctt tccagctgtt caagaaggtc gtttgttttt 2579221 cattttttta gaatcatact gcgatgattt tcgcttgtga agcttgcatt tatcttttgt 2579281 tgaactcata ttacgccgct ttggacgcag tgtcaacagc attttttaaa attattagac 2579341 aattttgatt aatcaatcta tattgtatac gctttcatta ttggtacaaa aggaattgca 2579401 aatgttaaaa gtttttataa tttttttatt aatctatcaa gaatacacca gaattattta 2579461 attttatata aacatggaag attttataac acgatatggt tcgtatatgg attgagtctg 2579521 acagatcatc ttgcaatcca tttcaatttc ggataggcac ttctcttgtt ccctcggcat 2579581 acattaatga tatcttgcaa agaaaaggtg atacgatgaa taaatcattt gcagacatgc 2579641 aaggatttcc tgcgggcttt ccaagcttcc ccaactttcc gcagcagtac tatcctgctg 2579701 tccctccctt ttaccagcaa agccagcagc catttggagg ctacggatac ggacagccgt 2579761 tcagtcaggc atacagcccg ttaaccactc cctctggaat gtactcctca ttcccatacg 2579821 cttcaggatt ttacggacag caattttcag gtgcaggctt tagcggccat ggcggcagct 2579881 taagtgctcc agcgatacat gccggcggat tcagcggggc gccaggcgta cacggaggct 2579941 ttagatatta aagaatacca caagggccga acatctattg cggtcctttt attgttttaa 2580001 aacgacttca caagtacagt cacattttct gtctttatat ttggaaacag gatggaatat 2580061 gattaagatg aattgaacga tattctgcac aatccgtaag ttttcgagga ggaataaaat 2580121 tgcatataaa aatagacgat ttaactggac gtcaggtggt ttcactggtg aatgagcatt 2580181 tacatagcat gacgcttatg tccccgccag aaagcattca tgccttaggt ctagaaaaac 2580241 taagagggcc tgaaataaca ttttggagcg catgggaagg tgatgaacta gctggctgcg 2580301 gagcgctaaa agaactggac acccggcatg gagaaatcaa atcaatgcga acatctgcat 2580361 cacatttaag aaaaggcgtt gccaaacaag ttctccagca catcattgaa gaagccgaga 2580421 agcgaggcta tgagcggtta agcttagaaa cgggttcaat ggcttcattt gagccggcaa 2580481 gaaaattgta tgaaagcttc ggtttccagt attgtgaacc gtttgcagac tacggtgaag 2580541 atccaaacag tgtgtttatg acgaagaaat tgtgagacgg ctttataagg atagataagt 2580601 gcaggggaag gtctgtctta tctatctttt tttatattca cacatttttc acctttatga 2580661 tacacgccaa tgttttcaat tttgtttaat tcaaagaaca gcgggaatta caaacgacat 2580721 gaacgatatc atgcaaattc ataaaggagg agattgatat gaaaagcata gttggtgtat 2580781 atgaaactcc gcaggaaacc atcgcagcga ttgaaggctt acttacaaaa ggctatgatt 2580841 ctgatgacat ttctgttgtg acaagccggc gagatacaga ttatttggag tcacgtacag 2580901 gaacagaagt caatcaagct atcgatgcac atcaggacga atctgaatct tttttcgata 2580961 aactgaaaga ttatttcaca atggatgata ctgctacaca cagcaaagca ttatccgact 2581021 tggatattaa aactgatgaa atagacaagt atcaagaaga tttggatgac ggaaaacttc 2581081 tggtagccgt cgatacagat gcagatgtaa ttgctcctat tgataacggc aatgcccttt 2581141 caggcggctt ttcaagcaca aatgaattgg attatacaac gaaagaagaa aaaacgatgc 2581201 cgctccggga agaacagctg aaggtcgata aggaagacgt tcaaaccggc gaagtagaaa 2581261 taggaaaaga agtgaaaaca gaaaaaagag atatggacat tccggtgaga catgatgaaa 2581321 tttatgtcga acgccgtcca gtggatgaaa ataaaacgga cgctgctccc gtcaacgatt 2581381 cggaagagat cagagttcca atcgttgagg aaaagctgga agtgactaaa aaaccggttg 2581441 tcactgatga agtggttgtc ggcaaacgca ctgttgaaga aaatgaacat atttctgaaa 2581501 ctgtgaaaaa agaagaacct cgtctgaata aagaaggaaa agttgacggc ttggatgatg 2581561 atccgttaaa taacaaatga aaatcataga ccgacaacaa aaaacctcaa atcctaaatg 2581621 gatttgaggt ttttcttttg gtacgtccca ggagagattc gaactcccga ccgacggctt 2581681 agaaggccgt tgctctatcc agctgagcta ctgggacacg ttttgttttt ttgtttttcg 2581741 ctttaactat cagcgacaag atttattata tatgggatgc aataataagt caacggtttt 2581801 ttagaatttt tttcatgagg aagaaaattt tcttcctcat gacattttca tagtgtgact 2581861 cgattttgca gatcctcaat ttcattgcct gcttggtcgt aaaaacggac tgtcgcagca 2581921 tcattttcta atgtcagtat agcatagctt tctgtcctgc gcaccctcgg aagccggatg 2581981 ctgcctgggt taatcatcag ttttccgcgc agcacttcgc ttcccgcgat gtgcgaatgc 2582041 ccgaagcaga taacatccgc cccgagctcc tctgcacgat agtatacgtt taacaaggtc 2582101 tgttttatac cgtgaaggtg gccgtgtgtg actagtattt ttcttgagcc ggcagtcaga 2582161 agaagctcgt ccttaaaatc gccggcaaaa tcgcaattgc cttttacaac cgcataaggc 2582221 tccaatgcag gatgcctcgt ctcaagctca gagtccccgc aatgaatcat gagatcaact 2582281 tctgcctcat gccgtttcgc aatggtttgg agttcttctt caagcccatg gctgtcactg 2582341 ataatcagca cgttcatgta caagcttcct ccttatgcct ccaaaagctt agacagcttt 2582401 ttaagcgcgt cagccctatg gctgatttta tttttttcat cacttgtcag ttcagccatc 2582461 gtcttatctt tatctttcac gataaaaatt gggtcatagc caaagccata ttctcctctc 2582521 ggttcttcag caatataccc ttcaacatgg ccttcgactg tttttgtttc ctctccggga 2582581 atactcacgg ccagtgcgca gcggaaacgg gcggtgcgct gttctttttc gatacctttc 2582641 agctcgctga gcactttttc gatatttgcc tggtcgtctt tctgttcccc tgcatagcgg 2582701 gctgaataaa ccccgggtct gccgccaaga ttatcgatgg atagtccgga gtcatccgca 2582761 atcaccattt tgttcactgc tttggcaaca gcttccgctt tcataatggc attttcttca 2582821 aatgtatggc ctgtttcttc aatttcctct gtgaatccaa tttcagctaa agatttgaca 2582881 tcatagcctc ttggctcaag aatttctttg aattccttca cttttcccgg attatgtgtt 2582941 gcaataattg cttctttcat gatgatcaag cctttctgtc tttatttcag ttctggcaga 2583001 gaatcaccca gcacttcttt ttgcttgtca atcagctctt ggattccttt ttccgcaaga 2583061 cccagaagac cgttcagatc ctctctagaa aaagttgcct cttccccggt tccctgcaat 2583121 tccacaaaac ggccgctgcc tgtcatgatg acattcatgt caacttcagc agaggaatct 2583181 tcttcataat ttaaatctaa caaaattccc tgttccttat caattccaac agagattgca 2583241 gcaagaaaat cagtgatcgg atttgtcttg attgttcctg ctttgatcag cttgccaatc 2583301 gcaatcgcca tagcaagaaa tgcgcctgta atggaagctg ttctagttcc tccatcagct 2583361 tgaatgacat cacagtcaat ccaaatcgtc cgttcaccga gcttttccag atctacaaca 2583421 gctcgaagcg cgcggccgat caggcgttgg atctccattg ttctgccgga aattttcccc 2583481 ttagaagatt ctctgattgt tctttggttt gttgcccgcg gcagcatgct gtactctgct 2583541 gtaatccagc ctttccctcc gccccgcaaa aacggcggta cgcggtcctc aacagacgcg 2583601 ttgcagatta cctttgtatt tcccgctgtt attagaacag aaccttccgg atggctgata 2583661 aaatccaaat cgaatgtgat tggacgcagc tcatcgtgtt gtcttccgtc atgtctcatg 2583721 ttttacctcc gattgtatgt acataaacca tttttgtccc ggaattgaat aaagaaagag 2583781 gcagccggaa cgctaacctc tttcttccta gtatatcaaa aatcccaatt taaaaactac 2583841 ccgtattcac ttgagatggt ctggagaccg gttctgtgag cttttcgcct ttttcattta 2583901 ccagctctga ttttccgttc actttaacag agacgctttt tacatccggc tgctccgtta 2583961 acgtcagcac aatgctgttc agcacttctg aagaaatcat tttcgtcttc tcatcggcgc 2584021 tgccgaatat agattgattg aaatccaacg tcacgcgccc gtctttgatt ttcggtttgc 2584081 tgaccagctt tacatcttca ctgaagtctg ttaacagccc gctcaccttg ctcggccctt 2584141 tagccaattc attaatggct gctgtgatgt cgtctttttc cgaattgtcg attcgtttgg 2584201 tcaccggcac gtagtattca ctgtcttcat tttccgccaa atagtagact gtcagcggat 2584261 gggtagcagt gagatcattt acaccggctg tttccaaatt aatgccgtct ttgcggctta 2584321 aatcatctga gatcggcgtc cctcctacag gcatctcctt cagttcatgc ccgtttattc 2584381 tcagcttcac tttatctatc gaactaaatt gcgtcagcgt ccacgtcaca gattgaacga 2584441 ttttctgttc gtcttctttc ttataatttt tgaactcatt agagaaatca gctatcgccg 2584501 ttccatcttt tttgatgtca acgttaacgg tggtgtcagc cggcaataca gctctgaagc 2584561 cattcggaag aatttcagac acaggcccgc cctgtacgag gtattcaagc gcctgcttag 2584621 ccgtgctctc acttttagga agaggcagcg tttgcgcaac aacatacccg tttttatcaa 2584681 tgagataaag ctccctcata acagtagatg aggcttgatc cgcttttgcg gtatcgcttt 2584741 tttcactttc tgtttttttg gctgctgttg tatttgaatt ggcacccgct tcatcgttca 2584801 cgaatgtaac gtcttgaggc ggatcaattt cctcggctgc cttatcagat tgaaacaaac 2584861 cgcatccgga taaaagcaag gcagaggtga gacaagtggc accaatgact gcaggtcctt 2584921 ttttcagcat acttttccct cctaaggatg tttgtactat tatgtatacg agcctcttta 2584981 ggaaatagac cgaagaattc cggcaaaaca gaaaaaaacc cgcaacatac cgttgcgggg 2585041 aaaactatct tttaatcggt tcttgcagtg agatacattc cacatgcccg acttcatggc 2585101 caaaccaatc gtctgcgatt tttgcaaact gatcacgcgc ccctgttgtc aggaactgat 2585161 gatccggggc aatcggagac tggttcagca gccctttata agagagaatt gtgctgactt 2585221 cccgggctgt ttcatcgccg gacgaaataa tgtttacgtg ctctcccata tatctttgaa 2585281 tggcttcttt taaaataggg taatgggtgc agcctaaaat cagcgaatca attgatgtgt 2585341 cttttaacgg atacagcgag gttttaacaa tctcgtctgc tgttttgtcg agaaacttcc 2585401 cgctttccac aaaaggcaca agcagcgggc aggcaaggtt ttcaaccttc aaatcagggt 2585461 ttaatgccaa aagcgcttct tcgtatgcat tgctcttaat cgtattctct gtgccgatga 2585521 caccgatatg ctgattatcc gtcactttta tcgctgctct cgcaccaggc tggatgactc 2585581 cgaccaccgg tataccgacg ctgcgctgga tgtcatccaa agcgatcgct gttgctgtat 2585641 tacaggcgat cacgagcatt ttgatgtggt ggttttcgag taaataattc gtcagctccc 2585701 acgtatattg aagcacctct tcttcagggc gcggcccgta aggacaccgt ttcgtatccc 2585761 cgacgtagat aatattttct ttaggtagct gtctcatgat ttccttcgca acggttaaac 2585821 cgccaacccc ggaatcaatg actcctattg gttgttccaa caaaatcgcc tcattttctc 2585881 ttcatttcat gctgcagttt catcaaagat ttttcgaaga tggctatttc ttcatctgta 2585941 aacgattcga acatatcacg cagatattcc tgtctttttg taatgacctc ttggataatc 2586001 cgttctcctt caggcagcag atgtatcctg acaacacgtc tgtccgccgg gtccttgacc 2586061 cgctcaacaa gctcattttt ttgcatgcgg tcgattaagt ccgttgtcgt gctgcatgcc 2586121 agatacattt tgcccgataa ttcaccgatt gtcatatctc ctaattcata aagccattgc 2586181 aagccgacaa attgcggcgg cgtaatcgca tattggttaa ggatttctcg tcctttttgc 2586241 ttaatgatcg cggcaatgtg gcggagtgac ttttcaatat ccgcaacatg ctccaaaggt 2586301 tttgatgtca tttgtccatc cctcactcaa ggatctctta cgcacaaaag cgttccgtgt 2586361 ctattttcct tcttttttga agaaaatgca agactcgcag gagagaaata gaggacttta 2586421 gtcaaacaac atcaagaaat aaaatttaat ttatgacttg cctacgtttt gcacagcatt 2586481 ccaaatatgg tttcgaatgt tccaaacaaa cagcaataac cggctccttc caaaagaagg 2586541 aataccggca aggattaaag ctctagctca cccattctaa gaagctcaac aacggcttgc 2586601 gaacgccctt tcacacccaa tttctgcatg gcatttgaaa tatggtttcg aacggttttc 2586661 tcactgataa atagctcgct tgcaatctcc tttgttgtct tatcttgaac gagcaattcg 2586721 aacacttctc tttctctttt cgttagcagc ggcttcgatt gaaattcttt ctccttcaag 2586781 tattgtaacc ctccttgcta aggtgagagc gaatcagaaa cgaatgggtt ttgatatagt 2586841 cgagatatca tatgtaagaa gggcgcagga ggtgacgttt acaagataat tagtttatcg 2586901 tgtatgaaga agcgtttctt tctcctcatc cgtccagctg acagccttgc cgctttcctt 2586961 tgagacttga accatcacga ctgccccggt gaagcagggt tcgccttcga ggttctctcc 2587021 gagatagtgc aaggtaagag atgaactgcc gactgcgctt gttttcacat agatgcgcaa 2587081 ctcttcataa ggcatgactt ggcgcaaata atcgcattgc tggcttgcca cgactgtcat 2587141 ggtctgtttg ttttcactca tcatattcag ctttttaaaa taagaaatcc gcacctcctc 2587201 aaaatatata aaaggggtta cattattcat atgcccaaac atgtctgtct cggaaaatct 2587261 tacggatacc ttattgaaaa aagaaaagga tgttttccat tcttgaaacg gcatatcaat 2587321 ataagcggga agcttcatct tttttcatct ccttattgtt taaaaaaacc tctcccatgc 2587381 ggaagaggtt ttttcttctt atactctgtc gcttccgaag aaattgcgga acgcttgtaa 2587441 gtttgtatct ctattcaagg ctgcaatcga agtggtaagc ggaatcccct tcggacagga 2587501 ttgaacacag ttttgcgagt tgccgcaatc tgcaaggccg ccttcatcca ttaatgcttc 2587561 taatcgttca gatttattca tggcgcctgt cggatgcgcg ttaaacaggc ggacttgcga 2587621 catcggtgca ggccccatga acttcgattt gctgttcaca ttcgggcaag cttcgaggca 2587681 gacgccgcat gtcatgcatt ttgataattc atatgcccat tgacgacgtt tttccggcat 2587741 tctcggcccc ggtcctaaat cgtacgtacc gtcaatcggt atccacgctt ttactttttt 2587801 caatgaatca aacattctgc tgcgatcaac ctgcaaatca cgaacgactg ggaatgtttt 2587861 cattggtttt aaacggattg gctgttcaag ctggtcaata agcgccgtac aagactggcg 2587921 gggttttccg tttataacca ttgaacatgc gccgcatact tcctcaagac agttcatatc 2587981 ccatgtgaca ggggttgtct tctcaccttt gacattaacc ggattccggc ggatttccat 2588041 cagagcggaa atgacgttca gattcgggcg gtatggaatc tcaaattctt catcataagg 2588101 cgtgctgtca gctgtatctt gacgtgtgat aataaatcgt atggtttttt gttcactcat 2588161 gattatttcg ccaccttctt cttcgagtaa tcccgtttcc gaggcgttat cagtgataca 2588221 tcgacatcct gatactcaaa ttccggcgct tcatacgggc ttacatgttt agccattgtt 2588281 gttttgagcc attcatcatc attacgttca ggataatccg gtttataatg ggcgccccgg 2588341 ctttcattac ggttgtatgc gccaagggta atcaccctcg caagctgaag catgttcgag 2588401 aactggcgtg tgaacatcgc tccctggttg ctccattttg tcgtgtcatt gatgttgatc 2588461 tttttgaagc gctccattaa ctcctgaatt ttgtcatccg ttttcaaaag cttgtcatta 2588521 tggcggacaa ccgttacgtt cgccgtcatc cactcaccga gctctttgtg aagaacatag 2588581 gcattttcgg ttccgtccat actcataata tcagcccatt tttcttcttc tttcttaacg 2588641 tgagcgtcga ataaagatga agacatgtct tccgctgaag attctaagcc gtttacatat 2588701 ttcaccgcat tcggaccggc caccatgcct ccgtaaatcg cagacagcag ggagttcgct 2588761 cccaagcggt tgccgccgtg catagaataa tcacattccc cagccgcaaa cagtccaggg 2588821 atatttgtca tttgatcgta atccacccat aaaccgccca tagaataatg gaccgccggg 2588881 aagattttca ttggaagctt acgcgggtcg tctcccatga atttctcata aatctcaatg 2588941 atgccgccaa gcttaatatc aagctctttc ggatctttat gagacagatc gagatatacc 2589001 atgttttcac cgttaatacc gagcttctgg ttcacacaca catcaaatat ttcgcgtgtc 2589061 gcaatatcac gcggcaccag gtttccgtat gccggatatt tttcctccag gaaataccat 2589121 ggtttgccgt ctttatatgt ccacacgcgc ccgccttcac cacgcgctga ttcactcatc 2589181 agtcttagtt tgtcatcgcc cggtatggct gtcgggtgga tttgaatgaa ttctccgttt 2589241 gcataatacg ctccctgctg ataaacgatt gacgcagcag atcctgtatt aatcatggag 2589301 ttcgttgatt ttccaaagat gattcccggt ccgcccgtcg ccataatgac agcgtctgaa 2589361 cggaaggatt caatttgcat gtttgtcagg ttttgtgcaa caattccgcg gcaggttctg 2589421 tcatcatcta aaacagcgcc aaggaattcc cagccttcgt attttgtgac cagacccgca 2589481 acttcgtatc tgcgcacttg ctcgtccagt gcgtaaagca gctgctgtcc cgtcgtcgca 2589541 ccagcataag cagttctgtg gtgctgtgta cccccgaatc ggcggaaatc aagcaggcct 2589601 tcaggcgtcc ggttaaacat gacgcccatc cggtctaata agtggatgat cgaaggcgcc 2589661 gcttcacaca tcgccttgac cggcggctgg ttggcaagaa agtctccccc gtataccgtg 2589721 tcatcaaaat gttcccacgg agagtcacct tccccttttg tattgaccgc tccgtttatg 2589781 ccgccttgcg cacaaactga atgagaacgt ttgacaggaa cgatggaaaa caatttaacc 2589841 gccattcctg attccgctgc tttaattgtc gccatgaggc cggcaagacc cccgccgact 2589901 acgataatgc ttgattgact catgatagcc cctctccctc tagtaatcta gtactcttaa 2589961 acaaatgcaa aaatcgcttt taagcctacg tatgacagtg caacaaaaat aatcagcgta 2590021 acgtatgtcg aaattctttg agaacgaggc gttaccgtga tgccccatgt aacagcgaaa 2590081 gaccataaac cgttcgagaa gtggaaaatt gttgataaaa caccgacaat gtaaaaacca 2590141 agcatagccg gagagctcaa aatattcgcc atcatgtcga aattgacctc agcacccatt 2590201 tgtgcggcaa tgcgggtttc ccacacgtgc cagctgacga aaatgagggt gatgataccg 2590261 gttacacgct gcaggacgaa tagccagttt ctcatgtagc tgtattgacc ggcgttattt 2590321 ttcgcagtaa acgctatgta cacaccataa actgcatgat aaattaatgg taagaagata 2590381 ataaaaattt ccaaggcata cctgaaaggc aggctatcca taaaatgagc agcgctattg 2590441 aatgcttcag cgccccttgc ggcaaactgg ttgacgacta aatgctgaat aagaaagatg 2590501 ccgaccggta tgacgccaag caaggaatgc aatcttcgaa aataaaactc tctgttccca 2590561 gacattactt taccccctgt ttgataagtg cgaaatgtgc taaatctctt cccccacttc 2590621 tttcaattgt aagcacttta ttaagattta ttgacaattt cattttactc ctccctcaaa 2590681 agggcgtcaa gaaaacgcgt acataaatta taattttccg aattgattag ttgattgaaa 2590741 aattttattt tatcaatata tatttcttgc ttaatttttc ataagaatta caggatcatt 2590801 ctgtaatcct cccccctgtt tgagctataa tatacgcagg agagagggga gacagatatg 2590861 aagtctaaat ttgaagcatc tattgacaac ctaaaagaaa ttgaaatgaa cgcttatgcc 2590921 tacgaactaa tacgagagat cgttctccca gatatgcttg gccaagatta ctcttccatg 2590981 atgtattggg caggaaaaca tctcgcccgt aagtttcctc ttgaatcatg ggaggaattt 2591041 ccggccttct ttgaagaagc gggctgggga accctcacca acgtaagcgc taaaaaacag 2591101 gagcttgaat ttgaacttga agggccgatc atttccaacc ggcttaagca tcagaaagaa 2591161 ccttgctttc agctggaggc tggttttatc gctgaacaaa ttcaattgat gaatgatcag 2591221 attgccgaat catatgaaca agtgaaaaag agagccgata aagtggttct gactgtgaaa 2591281 tgggatatga aagacccagt gtaatcaaaa aggcggtgac tgcatagtcc cgcctttttg 2591341 attgtcatta cacagctgaa gggtgttttg aaagctcaaa tgcatcgtga agcgactcga 2591401 ctgctttcac catgtcattt tcgcttacga ctgttgacac tttgatttca gatgtgctga 2591461 ccattttgat taaaatgttt ttttgcgcca gtacagcaaa catttcagcc gctacaccgg 2591521 gatttgagac catgccggat ccaacaatag atactttagc caatttgctt tctgtctcga 2591581 ttttctcaaa ttccagcgcg tctttatact cttcaagcac cgcaacggtt tggtctgcat 2591641 cttctgtttt gacagagaag gaaattccag tcttgtcctc ggcctgcgtt tggataatga 2591701 tatccacgtt tatgtttctt ttggcaagtg ttgtaaaaat agtagacaaa gttgtcaggc 2591761 cgctagtcag cccgtaaatg gttactcttg tgatttgatc ttcaaatgca atgcctctga 2591821 caattaaatt ctgttccatg gatgattcct cctcaattaa tgttcccgct tcggtttctg 2591881 tacttgaacg cacttctaac ggcacttggt aatttttcgc gaactcaact gctctcggat 2591941 gaagaacacc ggcgcctaaa ttggcaagct caagcatttc atcgtatgag atgccctcaa 2592001 gttttctcgc tgatttcaca tagcgcggat cggttgtaaa cacgcctggc acgtctgtgt 2592061 atatgtcaca tttatcagct tttaaagcgg cagccaaagc aactgctgtt gtatctgaac 2592121 cgccccggcc caatgtcgta atttcacaat cctctgtcat gccttggaat cctgcaacaa 2592181 tgacaatttt tcctttttca agctggtctg ctaaaaccga agtgtcgata tctgtaattc 2592241 tggcgtttcc gtgaatggcc tccgtacgga ttcccgcctg ccagccagta taagacacag 2592301 cgtcatagcc tttttcctgc aatgccattg aaaggagtga aatcgtgacc tgctcgcctg 2592361 tcgccagcag catatccatt tcgcgtttgc tcggctggtc agaaatagct tttgcaaggc 2592421 tgaccaattc gtcagtggat tttcccattg ctgaaacgac gacaacgact tgatggcctt 2592481 tctgtttttc tgcaattgcg cggtttgccg cattttgaat tttttcgact gagccgacgg 2592541 aagtgcctcc gaatttttgt acaataagac ccatgtatta ccacccttta cattttggtt 2592601 cgtgcgggtg aggagaaaga gcgctttgtc cacaataaaa aaagcaatga gaggaatact 2592661 ctcattgctt atcaattaat catcataaat gattatgaac aacgagatag ccctccaaga 2592721 aaatgatttc ttgacagcct tacatttatt caatgcacgg ccagcaaata ataccgatgg 2592781 ggttttattt gcttcggcga cgctcccctt tcagcctttt tcacagaatc catctttctc 2592841 caaaggcata ctcttgaagt tcgcacctct atcttcacca tataacacga tctaactatg 2592901 aaattagttc acattttatc agatcttatt taaaaggaca acattatttt tgcaatttgt 2592961 cgtaaaggag ctgagccgcc gctgcgggaa caccggcttt tttgatgtcc tcaaggcttg 2593021 cttccttcat ttttttaacg gaaccgaaat gctttaacag cattttcttt cttttctctc 2593081 cgatacccgg gatgtcgtcc aaaacggatt gaaacgcgct ttttccccgg atttgcctgt 2593141 gaaaactgat tgcaaaacgg tgcacctcgt cctgaatgcg ctgcaggagg taaaattcct 2593201 ggctgtttcg ttccagatac gccacctcca gcggatcacc gatcagtaaa tttgaggttc 2593261 tgtgtttttc atctttcgct aaaccggcga tcgggatatc caagccgagt tcattttcaa 2593321 tgacatccct tgctgcgttg atctgccctt ttcctccgtc aatgataatc agatcgggca 2593381 gcggcagatt ctcacgaagc actctcgtat agcgtcttct gacaacctct ctcatagaac 2593441 cgtaatcatc cggccctgta acagttttga ttttatattt gcggtattcc tttttgtatg 2593501 gtttgccatc gataaacaca atcatcgcgg aaaccgggtt tgtcccctgt atatttgagt 2593561 tatcaaacgc ttcaattctg tgcggcgtat aaatatttaa tgcctcacct agtttctgca 2593621 ctgccccgat tgaacgctcc tcgtcccgtt cgattaaaga gaatttttct ttcaatgcga 2593681 ttttcgcatt tttatgggca agcatgagca gttctttttt cgggcctttt ttcggctggt 2593741 gaacgtttgt ttccagtagc tgctcgatca tagattgatc tatgctgtcc ggaactaaaa 2593801 tctccttcgg aaggaagtgg ttgttttttg aatagaactg cccgatgaac gtgaggaact 2593861 cttcatctgc ttcctgataa agcgggaaca tgctgacatc gcgttcaatg agctttcctt 2593921 ggcggatgaa aaagacctgc acgcacatcc agcccttatc gtacgcgtac gcgaacacat 2593981 cacggtcgac tagatcgttc atcgtcattt tttgtttttc catcgttgat tcaatatggg 2594041 caatttggtc acgaagctct tttgctcgtt caaactcaag attctcagca gcttcatgca 2594101 ttttctcttc aagctctttt ttgacctcat tatagccgcc ccttaagaaa cgtgtaatgc 2594161 tttcaaccag ctctctgttc gtctcttcgg aaatatcctt tacacacgga gcaaggcatt 2594221 ggcccagatg atagtaaagg cacactctgt ccgggagctt ggagcatttt ctgagaggat 2594281 acagacggtc gagcagtttt tttgtttccc ttgctgcctg tacattcgga tacggcccga 2594341 aatagcgccc tttgtctttt ttgacattgc gggtgacaat cagccttggg tggcgttcat 2594401 gggtgagttt tatgaaagga taggttttgt cgtctttgag catgacgttg tatttcggat 2594461 catgcttttt gatcagattc atttctaaaa taagcgcttc aagattggag gacgtcacaa 2594521 tatattcaaa atcctcgatt tccgtcacaa gcctttgggt tttcgcgtcg tgagaaccgg 2594581 tgaagtagga gcgcactctg tttttcagca cttttgcttt ccctacgtag atcacagtct 2594641 gctgccggtc cttcatgaga taacaacccg gttgatcagg aaggagggcg agtttttctt 2594701 tcagttgttt gttcatatgt tacccttcct tatgtttaat cctttatttc cagtttaaca 2594761 cgaacgtttg tttttctcta tggttcacaa ttggcgaata aaaaaagcga tccctcaatc 2594821 ggaatcgctc tggcatgtaa gcagcggaaa attaaagatg tttgtttaca agctcttgaa 2594881 gcgcttcttt tggtttgaag ccgactgaag tttcaactac ttcgccgtct tttaacacaa 2594941 gaagagtcgg gatgctcata acgccgtatt ttccggcagt ttcttggttt tcgtctacat 2595001 cgatttttac gattttcagt ttgtctccca tttcttgatc caattcttca agaacaggtg 2595061 caatcatttt acaaggtccg caccaaggag cccagaagtc tgccagtacg acgccttcgc 2595121 ttgtttcagc tgagaaagat tgatcagttg cttttacgat agccattatt gaattcctcc 2595181 aatgtgaaat gatgattttt agtatagcat ctcccattcg ttcacgctat tttaatgctt 2595241 acaaattatt ttttcctgat cacagccggt ttactcattt ttatatggtt gaatgggata 2595301 tgctcttttt ttaaaacaca aatctgataa tggccccgat cactacaatt gccccaataa 2595361 tcattaaaat ggtacgaagc ataagatcac atctcctctt cactgtcatg tactttacca 2595421 tgccctgccg gagctgtttt aaaacctgaa aaagagcgcc ggcatgaagc tccggcgctc 2595481 ttgcgcgatt aagaatcagc acgcagcgta agtaagacga ctgacattgg cgggagtttt 2595541 actttcagtt tgtttttgct gagcgtgtat tgtctgaagg attccggttt gacatgatga 2595601 ggatcgtcaa acgtgttatg cgcattcatt ttttctgccg taagaatgac tccggaatgg 2595661 tccgctgcct tgtgtaggcc cctcagctcg atttccgcct ctgctttgtt ttggtgatcg 2595721 atgttgcaaa ttgtgatatt gatatcgcct tcagcttgtt tcgacgctga aatgctgatt 2595781 tgcggaagcg tttcaccgtt ccattcatag tcggcagaca ttgtctctgt ggctaaaaga 2595841 gaagcgtcct ggtgcacctt aaacatattg aatacatggt acgtcggtgt caaaagcatc 2595901 cgctctccct cagtcaaaat catcgcttga agaacattta ctgtttgggc gatgttggcc 2595961 atttgcaccc ggcggcaatg ctgatggaaa atgtggaaat gagaagccgc caccagtgca 2596021 tcacgaatgg tgttttgctg atataagaaa ccgggattcg tgcctggctc gggatcaaac 2596081 cacgtgcccc attcatcaat aatcagcccg acccgctgct ccggatcgta ccggtccata 2596141 atcgtgccgt gtttttgaat caattcatcg atgtatttgg cttttttcat cgtaataaac 2596201 cattcatctt ccgtgaattc tgtggctgat cctttgccct tccagaaatc ccccggaatc 2596261 gtgtaataat gaagactcaa cccgtccatc aggccagcgg cttttttcat aagcacgtcc 2596321 gtccaattaa aatcatccac atttgcgccg cctgcaattt tataaatgtc attcccgctg 2596381 taattgcgga cataagtctg aaaacgccgg tacagatctg cgtagtattc gggatgcatg 2596441 ttgccgccgc agccccagtt ttcattgccc acgccgaaat atttcagctt ccaaggctct 2596501 tctcttccat tttgctttct ccagtctgac atcggcgtgc cttcttcaaa tgtcatatac 2596561 tcaatccact ccgacatttc ctgaacggtt ccgcttccga cattgccgca aatatatggc 2596621 tcgcattcaa gcagctcgca aagcatcata aattcatgcg ttccgaattc atttgattca 2596681 attgtaccgc cccagtgagt gttcagcatt gtcttacggt caccgacacc gtttgcccaa 2596741 tggtattcgt ccgcaaaaca cccgcccggc cacctaagga caggaatgtg cagctgtttg 2596801 agcgcctcca gcacgtcctt tcgtatcccg ttgatattgg ggatgtctga gtccgttccg 2596861 acccagatcc cctcataaat ccctcttcct aaatgctcag caaaatgacc gtatatattt 2596921 ttgttaatgg ttccttttgc gatatctgtt tgaatcactg cttgatgttc agacatgcct 2596981 ctgatcattc ctttcatacg gatatgaaaa gcaccacagt caaatatgtg atctgtcgtt 2597041 tgcctgagga gtcagcatga atgtaagcgc ttttaaagta accatattat atatgttcgt 2597101 acatgtcaac gacattttct attgttttta tatttgtacg tatgtattta taaatatgaa 2597161 aaaacccgga cttttaaagt ccgggatttc ctttatgagt gtatattcag ctgtttgaat 2597221 tcctcagtta ataacgggac aacttcaaat aaatcaccga cgatgccgta atccgctatt 2597281 ttaaagatat cggcttcggg gtctttattg atggcgacga tcaccttgct gtttgacatg 2597341 ccggccaaat gctggatggc gccggaaatg ccgcatgcaa tgtacaaatc cggagtaacg 2597401 actttcccgg tctgcccgat ttggagagca taatcgcaat aatcagcgtc acatgccccg 2597461 cgagaagccc cgactgcggc ccctagcacc tctgcaagct cctgcagcgg ctgaaatcct 2597521 tccttgcttt tgactcctcg gccgcccgca acgataattt tcgcttcgga gagatcaaca 2597581 ccgtccgccg tttttttcac gacctcttgg ataacagtgc ggaggtcagt aagagaaaca 2597641 tcaatgcttt cgatgctccc cgatctgctg gtgtcttttt ctgaagcttg aatgttattg 2597701 gggcgaattg ttgcaaagat catcggatcg gttgaaatga cgcgttcaaa agctttcccc 2597761 gagtaaatcg gccgtgtgaa cacaacattc cctccggtaa cgcttacatc tatagcatca 2597821 gaaattaagc ctgtttgcag acgggcagca agcttcggtg aaagatcctt gcccattgcc 2597881 gtatgcccga agatgactga atcaggattt tcttgctcga taacacctct catgacctgg 2597941 ctgtacccgt ctgccgtgta tgttttcagc ttcgggtcct cagcggtaag aactttatct 2598001 gctccgtaat gaataagctc ttgtgcaatg ctttgtacat tttcaccgat gagaacaccg 2598061 atgacttccc catctcctga aatggttctt cctgcagcta ttgcttcaaa ggtgacattt 2598121 cgcaattccc catcgcgtat ttctccaagc acgatcactt tttttcccat tctaacatcc 2598181 ccctgtttct ttgaatgtcc aagttttaaa tgactttagc ttcgctgcgg agcaatgaaa 2598241 caagctcttt tgcctgttca gcaggctcac cttggagaag cttcccggct tcttttttcg 2598301 gcggcagaaa acgttcaatg gttttcagct ttggttcagc atcctcttcg tccagatcaa 2598361 gatcatcaag ttcaagctct tcaagcggct ttttcttagc cttcataatt cccggaagcg 2598421 atggatagcg cggctcgttt aagccctgct gagctgtgac aagcaatggg agcgtcgttt 2598481 tgattttttc aacatcccct tcgacgtccc tttctgcttc tgcatcagtg ccgttgattt 2598541 cgagtttggt gatcgtagtg atacacggaa tgtccagtag ctcggcaagc cgaggcgcca 2598601 cttgtcctga tcctccgtca atggcaacat ttccgccgag aatcaaatca aactcctgat 2598661 ccttcatata gtggtataaa acttgagaaa tggaatattg gtcgggttca tcaagatcat 2598721 cttctatgtt gattaaaaca gcttggtcac aacccatggc aagcgccgta cgcaattctt 2598781 tctccgcttc ttcaccgccg accgtgacag cggtgatcgt gccgccatgc ttttccttca 2598841 gctggatggc ttcttctatc gcgtactcat catatggatt aatgatccat tccgctccgt 2598901 catcctgaat ctttcctgtt tcaatgacga ttttttcttc tgtgtcaaac gtccgtttca 2598961 tcagtacaaa tagattcatg atcatatccc cttttattcg cctttgaact gaggctttct 2599021 tttttcgaga aatgcctgga tgccttcctt ggcgtcctct gactcaaatg cttccccaaa 2599081 tcgctttgct tcaagcttta agctgccttc ataggaatac accttgttgg aataaagaag 2599141 ttcaagcaaa gatgccagcg tttgcgggct tttctctgca aacttagcgg caagtgcttt 2599201 tgctttttca atcacttctg cctcatcttt cgctccaatt gagacaagtc cgagatcaag 2599261 cgcttctttt ccggatatcg gttctcctga tccgatgagc tccagtgctt tggctgtacc 2599321 gacatatctc ggaaggcgct gtgtccccgc aaaacctgga atgataccga gattaagctc 2599381 cgggagcccc agcttagcat cttctgccgc gattctgatg tgacaggcca ttgcaagctc 2599441 cagcccgcct ccgagagcag cgccgtgaat cgctgcgata atcggttttg gaaaactttc 2599501 gattctctcc attaactgct ggccgcgctc agcgagcaat gaggaatcct cattgccttt 2599561 aagcgatgta aattctttaa tatcagcgcc ggctgagaaa aatcttccct cgccgtgaat 2599621 gataatgctt cgtacgcctg catctgtctc acattgatca agacaggaag acagctcttc 2599681 taatatccgg cttgaaagcg cgtttgccgg cggattgtga atcgtcaaga ctgccacaaa 2599741 ttgatcaacc gcaagtgaaa ttgcattcat aggacagaac tcctttactt attgtgaatt 2599801 ccggatacca ataattctaa aacgctgttt gaaagcgcaa cgagatcgta cttttggtca 2599861 ttcatcaccc aagttgtcac agtttcgtca atcgttccaa aaatcatctg ccgggcgagg 2599921 cggacatcga ggccttcttt tatttcgcct gattgtatac cttccgtcaa aatgccatcc 2599981 aaaatattta agtagccttt taatatttcg ttgatttttt ggcgcagctc caagttggat 2600041 tggcggagct caagctgcgt gacaatggcg agattatggt cacccgctaa aagggaaaaa 2600101 tgctttgaaa tcacaagcgc caatttctct ttcgctgttg ctttttcttt aatgtcctct 2600161 tccatccgct caataaattg acccattttt tctttgaaaa gagaaattaa aatatcttct 2600221 ttgtttttaa aatagagata gatggtgccg tccgctaccc cggcttgttt ggcaattttg 2600281 gatacctgtg actggtggta gccgttttct gcaatgactt ctactgctgc atcaataatc 2600341 tgcatatact ttggccgttt ttgcttcaat gttcatcgtt ccttcctata gaaatgaatg 2600401 actattcatt cataatttca tgataagaag gattttcagg tttgtcaagt ttattcatag 2600461 gcgttctctt tttttatttg atatgatgat tttcggtttc ttcttcaagt aaacgccttc 2600521 ttaaaatttt tcccaccgcc gttttcggca gctcctttct gaactcatag gctttgggca 2600581 ccttataggg agctagacgt gatctcgcaa aagcgtccag ttcttctgta tcggcttttg 2600641 cgcctttctt taatacgaca aatgctttta ctgtttctcc cctgtaggaa tcgggaacgc 2600701 ctgcgacaac aatttcctgg atggcttcat gttcataaag cgcttcttct acctcacgcg 2600761 ggtaaatatt gtaaccgccg gcaatgatga tatccttctt cctgtcagca atatagaaaa 2600821 agccttcttc atccatatag cccatgtccc cggtgaacag ccagccatct ctcagcactg 2600881 cggcggtttc ctctggttta ttccagtatc ctttcatgac ttgcggacct tttacaatga 2600941 tttctccatg ctcatacgga gcggcaagct cacccgtctc ttcagaatag atcgcagcgt 2601001 ccgtactcgg ccaaggacag ccgatactgc ccggcttgtt ttttccccag ataaagttgg 2601061 cgtgcgtcac tggggatgcc tcagacaaac catagccttc cacaagcttt ccaccagtca 2601121 ccttttcaaa tttctgcttt acctccacgg ggagcgcggc tgatccgcta agacagcttt 2601181 taatggatga cagatcataa tgctgcaatt cagggtgatg caaaaggcca atgtaaattg 2601241 tcggtgcgcc aggaaagagc gtcggtttgt gtttgtcgat gattttaagt gtttcgagcg 2601301 gatcaaactt aggaagaaga atcatttcga agcctagttt aatcgaatag ttcatgactg 2601361 ccgtcagtcc gtagacatga aaaaatggaa cgatgcccag cactttttca gcgccttctt 2601421 tcacgtcata catccaagcg gcgcacattt cagtatttgc caaaatattt tggtgcgtga 2601481 gcatgacccc ttttggagct ccggttgttc ctccggtata ctggaggaca gcgatatcat 2601541 gctcaggatc gatcttcggg attgtcagga gttcagtttt ttcctgcttc atacaggaag 2601601 cgaacgtgtg aatgttagct gttttgtcaa agtcgatatg cactttttgt ttttgcgtca 2601661 gcgggtaaag aatatttttc ggaaaaggca aatagtcttt tacactggtt atcaaaatct 2601721 ggtcgactat tgataacgtt ttcattttta ttgccttcgg gaaaagcaaa tctaaggtga 2601781 tgattacact tacctgagca tctctaagct ggtattcaag ctcatgctcg gtataaagcg 2601841 gattcgtctg caccacgatg ccaccggcaa acaagacgcc ataataagaa atcactgttt 2601901 gcgggcaatt gggcagcata acagccactc tgtctccttt ttgcaggcca ttgcactgca 2601961 aaaaagctgc aagtttaaga gcatccgtca gaatgtcatg aaaggtgagt ttttttccat 2602021 aaaacgatat tgcggtttta tcagggaatc gtgcggcgga gtctgtcagg atggattgca 2602081 gggttttatt cggcaacgga agctcatgcg ggatatcgtt gggatactcg gcaagccacg 2602141 gcttttgaga ctgcataaaa cctccccttt cgattttaga gatccacctt atcattatag 2602201 cagatggacg gcaaaaaaaa gaaaaagaaa ggtaaatctt tctttttctc ataatatgaa 2602261 cagatatata agaccaatta acaaaaagat tcccgctgcg gcgagcagta ttttcgcaag 2602321 cttttccatc tattctccgt ccccttatat tccggctgcc accacaaaag aaagcccgac 2602381 agaaatgaca aatgaaataa agccgacagc ccggttatca ttttcgattt cctgatcaat 2602441 tttaaaccgc ggagtcaaaa actcaaaaat aaagtagctg atcagaagca taacaaaccc 2602501 gtaaacgccc cagccgatca tttgcagcag cgaattatgc tgggagatgg aatgctgaaa 2602561 tacgtttgcg attcccaaaa tttttccgcc ggtcgccatt gccaccgcaa gatttccttt 2602621 ttgaatctct tcccagtttt tataagccgt caccagctca aacacagtca aaaagaggac 2602681 gaggcagaga accgcgacac tgtaatatgc cgcgatttcc acaagctcgt tttcccaaaa 2602741 atcactcatg gccatactcc cttttatttt agttcaacaa ccgtaacgcc tgatcctccc 2602801 tcacctgctt caccgaaacg ggaacttttg acgctgcggt ggtttttcag aagatcctgt 2602861 acgccttttc ttaaagcgcc ggttcctttt ccgtggatga ttgacactct tggatatccg 2602921 gctaacaccg catcatccaa gtatttttca acccggctga gggcattttc atagcgttcg 2602981 ccgcgaagat caagttcaag cgatacgtga tagtcctttc ctttgaccgc tgtaatcatt 2603041 ttttcttttt ttggctccgg agctgatttg ataaactcca gatctttttc ttttactttc 2603101 atctttaaaa taccgatttg aacgttccat tcattgccgc ctgttttttc gagcaatgtt 2603161 cctttttgcc cgaaagtgag gactttcacc tcgtcgccag gcttaaagtc gcgtttttgc 2603221 gttttcggct tttccggttt cttggacttt tcaaaagcag gcatagcgcc ttctaaccgt 2603281 ttcttcgcgt taatcagctc gtgatccttg aaggatttgt gttcttcttt tatggtgcgc 2603341 aattcatgaa taatgtcctc ggcttctttc attgccgctt ttactttttc agcagcctgc 2603401 tgttctgcct cttcaagcat tttgtctttt ttgctgttaa gctcgatgat ttgctgctgc 2603461 agctctttat gcagtttttc cgcttctttt ctgattgatt ctgtctcaga aagctcttct 2603521 tccgcacgtt ttttgctttg ttccagcgac gcaatcatcg tatcgacttc gttatgctcg 2603581 gccgtcattt ctgacttcgc ctgcccgatg atatggtccg ggagcccgag gcgttttgaa 2603641 atttcgaaag cattgcttcg acccggcaca ccaattaaaa gtttataggt cggtgacagc 2603701 gtttcgatgt caaattcaac gctggcattc atgacgcctt ctctgttata gccgtacgcc 2603761 ttcaattccg gataatgcgt cgtagctaac actcgtgcat tggtgcgatg cacgtcatcc 2603821 aagatgctca tggcgagggc cgccccctcc tgcggatctg tccctgcacc aagttcatcg 2603881 aaaagcacaa ggctgttttc attgacctgt tctaaaatgc cgacaatatt caccatatgg 2603941 gatgagaacg tacttaaact ttgctcaatc gactgttcat caccgatatc agcgaatacg 2604001 tgctcaaata ctgccgcttc tgacccttca tctgccggga tatgaagacc tgactgcgcc 2604061 attaaggtta gcaggcctaa cgttttaagg gtgactgttt tccccccggt gtttggccct 2604121 gtgatgacaa tggttgaaaa atcgcggcca agctcgatgt cattggcaac aacctgatca 2604181 ggcggaagca atggatggcg ggcttttttc aaacggataa agccggtgtc gttcataatc 2604241 ggttttgtcg ctttaaccgc ttttgcatat ctagcttttg caaaaataaa gtcaagcgtc 2604301 tgcagcactt gcaaatctag aaatagctcc tctgtatact ctgccgtttt ctctgtcagc 2604361 acacgcaaaa tccgttcaat ttcttgcttt tctttcactt tcgcctgctg aagggaattg 2604421 ttcatatcta caatcgcctg cggttcaatg aatagtgtcg caccagagga tgaggtgtcg 2604481 tgcacaattc ctccatagct ggatctgtac tcctgtttga ccgggatcac aaagcggtca 2604541 ttccgaatcg taacaatcgt atcagacagc attttcgatg cggaagagga acgcagcatc 2604601 gactctaacc ggtctctgac tcttgattcg agtgttctga gctgtgtgcg gattcctctt 2604661 aatgtttccg atgcatgatc aagcacttct ccgtgatcat caatgcagga attaatgtcc 2604721 cgctctaaat cggacagcgt gataagctgt tcagcatgct gatggatcag cggaatgtcg 2604781 acaccgtctt cagccatttg cgtgataaaa tgtttcattt gtttaactgc ataaagcagg 2604841 cctgagattt cagtgaattc agaaggactg agaacgctgc cgatttccgc ccgtcttaac 2604901 gctcctctga tatctacaag gccgccaaat ggcgcttggc ctctcagccg gataatgtca 2604961 gaagcttcgt ctacttcatc cagctgtttt ttgatttcgt ctatagaagc agaaggctta 2605021 agctcgagaa gcatttcttt tccgagcgat gaagcggcat gcccaataac ctgttctttc 2605081 actttatgaa attcaagagc tgataatact ttttgctgca cgattgtgtg agcctcctta 2605141 cttaatcgtt gcgcttcaga aatgcctcta cgtctttaag cgaccgggca ttcagaacgt 2605201 ttttcgtttc cgtccatcct ttgcgcgcgg cagtaacgcc agttttcata tcgtctaaca 2605261 tctcaatatt atgggcatca gtattaatca ccaatgtaac cccttgttcg tttgctttca 2605321 ttaaatgctc tgtgcgcaga tcaaggcgcg cagggttggc attgagttca agcgccgtat 2605381 ttgttttcct cgcaagctca atcagctgat caatatcgat ttcgtaaccg gcccgtctgc 2605441 cgataaggcg cccggtcggg tgtgcgataa tgtcaacatg cttgtttgtc agtgccgtct 2605501 caagccgttt cataatcacg tgttccggct gattaaaact ggaatgaatc gatgcaataa 2605561 cgatatccat ttccgcaagc acatcgtcat cataatcgag cgtaccgtca ggcaggatat 2605621 ccatctcaac gcctttcaaa atacggaagt tttcaaactc tgcattcagc gcgtcaattt 2605681 cttttgcctg ctgcttaagt ctttctgcag taagcccgtt ggcgaccttt aaatattgtg 2605741 agtgatcggt gatcgccatg tattgatagc cttttttgat gcaggcttca gccatctctc 2605801 tgatcgaaaa tgcgccatcg ctccacgttg agtgcatgtg gagatcacct ttgatttgcc 2605861 cgagctctat cagttcaatg ctgtcgctgt aggtttccac ttcctgtccg ctttcacgaa 2605921 tttccggcgg aatcagcggc aggccgaagt gcgcataaaa ttcacgttca ctcggaaatg 2605981 ttttgatctc tccggtttca actgtctcaa cgccgtattc actgatccgc tcgccgcgtt 2606041 ctttggcgat ttggcgcatc ttaatattgt gatcctttga tcccgtaaaa tgatggagtg 2606101 ttgtcggaaa ctgctcttcc gtcacaagac ggaaatcgac gcttgtttca tattcaaagg 2606161 aaaggatgac ggacaccttc gtatctccgc ttgcgatcac gcttttgatg tttggcagct 2606221 caagaagctg ctctcttact tcagccggat gatctgtagc aatgatataa tccagatcct 2606281 tcaccgtttc ccgcgctctg cggagacttc cggcacgaga aaatttgatg atatgcgtaa 2606341 attgagaaag atgctcctca atttcccgcg cgatccggag ggcgtagccg atcgggaacc 2606401 gttcaggctg ttttccggct tccccgagcg cctgtaatat tttttcttcc gattttttgc 2606461 cgaagcccgc aagaccctgg accttttgct gctcacaggc ttccttcaga gattctgcat 2606521 cgtgtacgcc gagctcttta tacagctttg cgattttttt gccgccgagc cccggcagct 2606581 tcaataaagg cacgagtcct tccggcactt ctttctgaag cgattcgagc gtgcttgact 2606641 ttccttcatc tatatactct ttaatgacgc tgtacgttcc ttttccaatg ccggacagcg 2606701 acatcatatc gtccatttct gataagcttc ggtcgtcctg ttccagagct gccgccgctt 2606761 ttcggaaggc ggatacttta aacgggttgt cccctttgag ttccatatag actgcaatgg 2606821 tttcaagcag ccggataata tcttttttat gcatatcata acccccagac gttcacatat 2606881 gtttccatca tacttgaaaa aaacttctcc ggacaagaga agttttttta tgccccgtac 2606941 tgtgtccaca gctcttgtaa aagccctgac aagtacggtg tatggttaat gatcacattt 2607001 gcgagagacg attgccccat catttgctgc aacgcgtcta ccggcagaac ggatgcgaca 2607061 tacagcagca caaatgtaaa taaatagact tctagaaaac cgagaacggc tcccagcatc 2607121 tggttgattt gtttaatcac cggaatgccg gctacaatac tcaggaacga gccgatgatt 2607181 ctcagtaaga ttttagcaat gataaataaa acgataaacg caatcgcatt atagtacgct 2607241 gcttccaaat tccccgtaaa aaaagaaaga gccggctgtc ccgctgaaaa atcgggtgcg 2607301 ggaatccaat gtaaatgcgg tgccacgttt ttatagaata aagccgcaaa ggcaattgat 2607361 aaaataaagc tcgtcaagcg gataaactgc aggataaaac cgcgttttaa ccccagtaaa 2607421 gtccccatca ggagcaagat taagatgatg atatctagca tagttgttca atccttttct 2607481 ttaagctgac gctccagttt ttcacatttc tcttgtaatt tgacataatc gtgcaccaca 2607541 tttaccgctg tcagcactgc aagtttattt atatcaaggt atggattttt ttcattgatt 2607601 tctctcattt tatcatcaac aattccggcg acatacctca tatgggctct gctttcttca 2607661 ccgacaatcg tgaagtgctg gccgtaaatg tcaacggttg tttttgtttt tttgccgtca 2607721 gacaacgttt ctcctccatt ccgcgagaat cctagttctt atcataacac gtttattaaa 2607781 tgaatggaaa gacgagcctc ccgctgttat gatacactgg tatatacagc gaaaagtgta 2607841 aaaaaaggag attattacgt gtcccattca gtgataaaag tatcgttgtc tgctattgac 2607901 caaatgaaaa tgacgtacag cggttcactt acagcctctg ttccgcaggg agccgttttt 2607961 caggcaaaac cgcccggctg taccattaca gcatatcaat caggtaaggt cttgtttcaa 2608021 ggaaaaaacg ctgcggcaga atccgcgcgc tggggaacag cagagcctca ggaaaagaag 2608081 aaaacggcca aaaagccggc tgatccccgc tatgcccctc cggcagatat cgccggaatg 2608141 tctgttatcg gttctgacga agtcggaacc ggagattact ttggcccaat gacggttgta 2608201 tgcgcgtacg tcgacaaaac catgcttcct ttaatgaagg aactcggtgt taaggattct 2608261 aaagatttaa aagatccgca aatcatcgag attgcccgaa acctgattaa aaccattccg 2608321 tacagcctgc tggtgttaaa gaatgaaaag tataacagca tgcaggaaaa aggcatgagc 2608381 caagggaaaa tgaaagcttt gctgcacaat caggcgatca cacatttatt aagaaaattg 2608441 gatggagtaa agcctgaagc cattttgatt gaccaattcg ctgagccagg cgtctacttc 2608501 aatcatttaa agggcagaga cattgtgaag gagcggacct attttagcac aaaagctgaa 2608561 ggtattcacc tggctgtcgc cgctgcttca atcattgcaa gatattcatt tttaatggaa 2608621 atggataaac tatcacgcgc ggcaggaatg acgcttccaa aaggggccgg tccgcacgtc 2608681 gatgaagcgg ccgccaagct gatcctcaaa aaaggggcat ctgcactcag aacctttaca 2608741 aaactccatt tcgccaatac gcaaaaagcg cagcgccttg ctgataaaaa acgttcatag 2608801 aaaaaagctt gcagatttct ctgcaagctt ttttatcagc ctcttaaaac agcttgatat 2608861 gtgtcttcta acgctttcag cactttgctg tgcgcctttg tcacttcttc ttcagtcagt 2608921 gtttgttcag gattgacata ctggagtgag aaagcgactg acttcttgcc ttcctccata 2608981 tgctctcctt cgtatacgtc aaatacggtt acctctttca gaagcttgcc cccggcctct 2609041 ttaatgacgc tctcgagctg tccgcttgtg acggttttat ctgttacaag agcgatatca 2609101 cgtgtcacag acggatattt tggaatcgcc gtgtaaacaa gcggtgctgt ttctgctgcg 2609161 agcaacgcat gaagatcgag ctcaaatacg tatgtttcct ttatatccag ttctttttcc 2609221 aatgaaggat ggacttggcc gatgaagccg atcagagaac cattcaataa aatgttcgct 2609281 gttctgcccg gatgcagctg tttgcgttca gactgtacaa attcaatgct gtctaggacg 2609341 ttgagtttgt ctaacagccc ttccacaatt cctttgacaa caaagaaatc aactggtttc 2609401 ttttcaccct gccatagctg cttgcgccat aatccggtaa cagctcctgc tacgcgttct 2609461 gtttcaacag gttttgtgtc ctcttccttc gttaggaaaa cggagccaac ttcgtacagt 2609521 gcaactgagt cagtctgcct cgcaagattg taagaaacag aatcaagcag atttggaaca 2609581 agactgtgtc tgagaatgct tctttcttca ctcattggaa gcgcaagcac agtattcagt 2609641 gatttttcaa tcgcaaacgc tgtcgctttc ttctcgtttg tcagtgagta agtgatggct 2609701 tgtgataagc ctgcgccttc aaggaagcgt ctgactttac ggcgttttgc ctgatatggc 2609761 gttaatccgc ctgtagttcc cgctgtctca ggaagcgtag acggaatgtt atcgtagccg 2609821 tacagtcttg ccgcttcttc gattaaatcc tcttctattg taatgtcacc gcgccgtgat 2609881 gggacagtca caacgagaag atcatccgct tcaccgaccg taaaaccgag acgtttataa 2609941 atgctgatca gttcttcttt actgatcgtc aggcctagaa cgctgctcac tttgtcagca 2610001 gatacgtgaa tgttatttgc ttcgattgtc aggtgatctt cctcaaccgt tccagcaagc 2610061 acctcaccgc cggcatacag atggatcagc tgcgcagccc gttctgctgc aagacgtacg 2610121 cgtgccggat caattccttt ttcaaatctt acgcttgatt cacttctcaa accaaggtct 2610181 ttggaagcct tgcgaacctt ctgcccgttg aaatacgcag cctcaagcaa aatggttttc 2610241 gtatcttcct gaacctctga ctctgctcct cccatgacac cggcaacggc ctgcgctttc 2610301 gttccgtttg taatgacaag gtgatcggca gacagcttac gttcttgatc atcaagtgtt 2610361 acgatcattt cattctcagc tgcttttctt actacgactt ccttagagcc aaatctgtca 2610421 taatcaaacg catgaagcgg ctgtccgtat tccaacagga caaaatttgt gatgtcaacg 2610481 acgttgttgt gcggacgaat gcctgcattc atcagctttg tctgcatcca aagcggtgac 2610541 ggagcaatcg tgacattttt aatgattttt gcagtgtaca gcgggttcgc ttcttgatct 2610601 tcaattttga ctgaaatgta atcagacgct tgttctgaag cagccgggta atccgtttgc 2610661 ggaagcttta cctcagtgtc taaaatcgcc gcaacctcgt aagcaacacc aagcatgttc 2610721 atggcatccg cgcggtttgg cgttaaaccc agctcaagaa tcgcatcgtc aagctgtaaa 2610781 gccgctaagg catcgcttcc tgtttcagcg tcattcggga atacgaaaat gccttctgca 2610841 tactccttcg ccacaagttt gctttcgata ccaagctcct gtaaggaaca gatcatgccg 2610901 tttgattctt caccgcgaag cttggctttt ttgattttga aattgcccgg cagcaccgct 2610961 ccgactgttg caactgcgac tttttgtccc ttatccacat tcggcgcgcc gcaaatgatt 2611021 tgtacagggg cttcagctcc gatatccaca aggcacttat tcagcttatc agcattcggg 2611081 tgctgctcgc gctccagcac atggccgatg acaacgcctt tgatgccttc tcctttgtat 2611141 tcaattcctt caacctcaat accggctctt gtaatttttt cagcaagaac agccgggtcc 2611201 atgcctttta aatcaacata atcctctaac catttataag aaacaaacat ccttgcatcc 2611261 tcctcttacg cctgtttaaa ctgcgaaata aatctgacat cgtttgtata gaagtggcgg 2611321 atatcatcaa tgccatattt cagcatcgcg atgcgctcaa cacccattcc gaatgcgaag 2611381 ccctgatatt ccttcggatc aaagccagcc attttaagca cgttcgggtg aaccattccg 2611441 gcaccgagga tttcaatcca gcctgttcct ttacatactg agcagccgtt cccaccgcat 2611501 ttaaagcatg tcacatccac ttctactgaa ggctcagtaa acgggaagaa gcttgggcgg 2611561 agtctgattt cacggtcttg cccgaacatt tttttcgcaa caagttcaag cgttcctttt 2611621 aaatcactca tgctgatgtt tttgtcaacg acaagccctt caatttgcat aaattggtga 2611681 gagtgcgtcg catcatcgtt atcacggcga tatactttac ccgggcaaat gattttaacg 2611741 ggacctttgc cttcatgctt ttccatcgta cgtgtttgga caggagaagt ttgcgttctc 2611801 atcaaagttt cctctgtgat gtaaaagctg tcctgcatat cgcgcgctgg gtgttctttc 2611861 ggaagattga gcgattcgaa gttgtagtaa tccgtttcaa cctctggccc ttcctcgact 2611921 gtgtagccca taccgataaa taaatcttca atttcttcaa tgacaacagt gagcggatgg 2611981 cggccgccga ctgcaacagg gttccccggc agcgtgacgt caattgtctg tcctgcaagc 2612041 ttctgtttca tttcctcttc ttcaagcttc tcgtttttgt cagcaatcgc attggcaata 2612101 cgctccctta cttcgttcgc gagcgccccc atttttggac gttcctcagc agaaagcttg 2612161 cccattccgc gcagcacttc tgtaatcggc cctttttttc cgagatattg cacccgaata 2612221 tcattgacaa ccttcaatga gcttgccgct tctacttgtt ctaaagcttc ttgttccagc 2612281 tgttttagct tttcttccat tttgcatcct ccttttatgt aaacaaaccg tcatatgtct 2612341 ttggaaaata aaaaaaaccc gtcccttgta caagggacga gttgtggccg cggtaccacc 2612401 cttatttcag acagactgat gctgtcgtca gcttcattga cataacggaa tcagattccg 2612461 gttcaccttt acgcgcagtg tacgcggtcc cggcgacaac tcaagaggtg aagccaattt 2612521 ccggctgcgt taaaaatgct ctcagtcagc ggcattttct ccctggaaag cagttgatca 2612581 gaaattgagg tcctctgtca cggtttttga aatattatgt tctattatag agaaatccaa 2612641 cgcttggcgc aacactatcc tcgcaagtga tacacgagga tggcagccgc aaccgcaacg 2612701 tttagtgatt cagcctgtcc gtaaagcggc acgtacaggt tcaaatccgt tttttccagc 2612761 aatgcagcat ctacccctgc accttcattt cctacaatga gcgcaaagga ttcagactga 2612821 ggaatctcct ggtaaggcgc tccgttttgc agcgccgtgc cgtatacttt tacgccctct 2612881 gccttcaatt cgtccacata tgaaggcagg tttcttctca caacaggaat atggaagtga 2612941 gatccttgag cagatcgcag tgtttttccg ttaaaggcgt ccgccgtgcc gtcaccgagt 2613001 acaaccgcat ccaaaccggc cgcatcagcc gttcgaatca ttgtgccaag gtttcccgga 2613061 tcttgaacag cgtcaatcag cagcaccttg cgtgccgttg ccagcttttc ttcaggcata 2613121 tggcacacag cggcaatctg ctgcggcgtt tcggtttcag tcacagctga aaacgcatct 2613181 tcactcagca tatagcactg gataccagtc tcaagatctg aaggaatcct cgtttcatcc 2613241 tttacaagga tttctttcac aatgcccggg cttttcaacg cctcttcaac gaggtgttct 2613301 ccctctatca gaaatgtatt tgtttttgtt cgttcttttt ttgtgtgaag ctttttccaa 2613361 tccttcactt tttggttttt tgccgattct atttgtttca ctgtctatgt ggcgctcctt 2613421 tttttaacat gatgttatta tatcgcaaga acagcacata ataaaccagg tgcagggtta 2613481 gaatatacgt attacatttt agaaaaagga gcgttttaca tggatcttaa tttacgtcat 2613541 gccgtcattg ccaatgtcac cggcaataat caggagcagc ttgagcatac aatcgtagat 2613601 gcgattcaaa gcggtgaaga aaaaatgctt ccagggctcg gcgttttatt cgaagtcatt 2613661 tggcagcacg catccgaaag tgagaaaaac gaaatgctga aaacgcttga aggcggatta 2613721 aaacccgccg aataagacat gaaaccgggt gacagcgccc ggtttttttc ttatataata 2613781 aaaacatgat gagggggaac gccatgtttt tacagccgtt attagcgaaa aaaattattg 2613841 ctgaagttaa aaaaatgtac gaacgtgaag tcattattgt aaacacggac ggtcttatta 2613901 tggcaggcac aaacgatgag cgtgtcggac aatttcatga gggagcgctt atctgcgcaa 2613961 aagaaagacg cagcgtgatt attacaaaag aagatgaaac aaggttaaaa ggagtgaaag 2614021 caggcataaa cctccctgta ttttttgacc atgatgtgat tgccgtcttc gggctgacag 2614081 gtgagcctgc agagattcag ccattcggag aactgcttcg aaaaatgaca gaactgttca 2614141 ttaaggaatc gcggcactta gagcaatccc agtggcgtga gagaatgctg gagtccttta 2614201 tgatcgattg gctgcaatta aaggagtggt ctcccagttt tcttgagaaa gctcagcttc 2614261 ttggtgttga cctttcttcc cggcgccaaa tgattcttat tcaggggtat gagtggtcac 2614321 ctcatgatat tgaacaaatg gcacgcagct ggaaatcctc gtaccctgcg gatttgttca 2614381 tcaggtgggg aaatgaacgg attttgatta atcatgaagt gccgcagcat gaacaaaggg 2614441 atcggctttt gcggaaaatc cttcacattt gttcgtttgc caataccgca agcagccaat 2614501 atacagcagc tggcgccgga agggctgtcg caagctccag cctgacagat tcatacgagc 2614561 aagcggaaaa agcgctggct gtcagcctta agcgaaaaac gcccatattt gaagaggatc 2614621 tgaagcttga tatgtgtctg acggagatca gcccgggaac ccgaaacgaa tttccgcaaa 2614681 gagtattagg aaaggcgcta gagcatcagg aacttatgaa tacgatacgg actttctttc 2614741 atcacgattt gtctttgaaa caaaccgctg aagacatgca tatacacatc aatacattgc 2614801 gttatcgtct ggctaaggct gaacagctga cgggattacg ttttgaccgt accgaggacg 2614861 tcgtcacgat gtacgtcgca ctctattttt tagatcaaga tacaaaatag agagagtttc 2614921 agtttcattt tttgtatgtt tctccatgga aggctttgct ttttttcttt tacaatagat 2614981 tgaaagcgtt ttttgacagg gggatgggtg aaatgatcac caaggatgta aaggagcagc 2615041 tgattcaggt ctccggacca gaaaactttg atgactcgaa tgccggccgt ctcgtctatt 2615101 catatgatgc gacgcctcag tatcagtcta tgcctgatgc cgtgattgct ccgaggaata 2615161 ctgatgaaat atcacgcatt ttaacaattt gcagcgaaca tcgagtgccg atcgttccaa 2615221 gaggatcagg gacaaacctg tgcggcggca cgtgcccgac tgaaggcgga cttgtgcttc 2615281 tctttaagca catgaaccag attcttgaaa ttgatgaaga aaatttaact gccacagttc 2615341 agccgggcgt cattacgttg gatatgatcc gggcagttga aagcaaaggt ttattttatc 2615401 cgcctgaccc gagttctatg aaaatatcaa ctatcggggg caacatcaat gaaaattccg 2615461 gcgggctacg cggattaaaa tacggtgtca cccgcgacta tgttattgga ctggaggttg 2615521 ttctcgcaaa tggtgacatc atccgcaccg gcggaaaact cgcaaaggat gtggccggat 2615581 acgatctcac acgtcttttt gtcggctcag aaggaacact cggcattgtg acagaggcaa 2615641 tcgtcaaact cgttccaaag ccggaaacaa agaagacgct gcttgccctt tatgaaaaca 2615701 tcgatgccgc tgctcaaacg gtatcggaca ttattgccgc aaaaattata cccgctacgc 2615761 ttgaatttct cgatcagcct acactattgg tgattgagga ttatgccaaa atcggacttc 2615821 cgacaagcgc aaaagcagtt ctgttaattg aacaagacgg gccatttgaa actgttgaac 2615881 gggatatgga aaagattgag gcgatctgca aaaaaggcga cgccgtatcc gttcagaccg 2615941 cacaaacaga ggaggaagcg tttgccctga ctgaagcccg gcgttctgca ctttctgccc 2616001 tagcccgcct caaaccgacg acgattttag aggatgcgac cgttcctcgc tcagaaatcg 2616061 ccaatatggt taaagcgatt aatgatattg ctgctaaata tgatatttcc atctgcacct 2616121 ttggtcatgc gggagacggg aaccttcacc cgacatgcac gacagacata agaaataagg 2616181 atgaaatgga acgtgtcgaa caggcttttg ccgagatttt tgagaaagcg attgaacttg 2616241 gcgggacgat aaccggagag cacggagtcg gggaaatgaa agcgccttac ttggaaatga 2616301 agctgaaaaa agaaggcatt gatgcgatga aagcgttgaa agcggcattt gacccccgga 2616361 acatattaaa tcccggcaaa atgtttgcga aagatgccag aaaacgtgtg gtggcggaaa 2616421 gatgacaaca gaaaaagaaa tgaaacagat ccaaaatgaa tttaaagagc gtatggatga 2616481 aggagagtta ttaaattgta tgcgctgcgg cttctgtctt ccttcctgtc cgacctatat 2616541 cgaatcggga tttcaggaaa cacactctcc gcgtgggcgc atcgccttaa tgaaagccgt 2616601 agccgacggt atgattgaac cggatgaaga tgtcgaacgg tcgctgtcac tttgcctcgg 2616661 ctgccgcgcc tgtgagcctg tatgcccgtc tggcgtgaaa tacgggcagc tgcttgagga 2616721 agccagagat attatccacc aaaataaaaa acactctctt ggtgaacgtg tcatgcgaaa 2616781 gacggctttt cacgagctgt ttccgcatca aaaccgcatg cgctcagctg taagccttat 2616841 cggtttgtat cagcgttcag gactgcaaac cgctgtgcga aaatcaggca tgcttcgggt 2616901 cctgcctgag catttgcgga cgatggaagc tgttcttcct gatgttccaa aaagcaaaga 2616961 catgaaacat cggccgcgtt tcctgccttc cattggcccc atgaaaaaac gggtcgcctt 2617021 tttttcgggc tgcttaatgg atacaatgtt tttaccgacc aataacgcca cattgaagct 2617081 tttacagctg gcaggctgcg acattgtcat tccgcctgaa caggcttgct gcggggcgct 2617141 tcatggacac agcggtgaaa aaaacacagg gaaagagctc gcgaaacaaa atatcgctgc 2617201 tttcgaagca ttagacgtgg atgcagtcat tacaaacgca ggaggatgcg gagcctttct 2617261 cactgaatat gatcatttgc tgaaggatga ccctgagtgg tcggaacggg ctgccgcttt 2617321 tgttcaaaag ctgaaggatt tttcttctgt tttggttgaa ctcgatttcc atcaaatgga 2617381 tctagcactc gagacgcctc aggtcgttac ctaccaagat tcatgtcatc taagaaatgt 2617441 gatgcatacg tcactcgagc cccgccagct tcttaaaagc atcaaagggg cggaattcaa 2617501 agaaatggag aaagcagaca gctgctgcgg gtcagcggga atttacaaca tcgtcgaagt 2617561 tgaaatgtct atgaaaatac tggacagcaa aatggctgcc gtcaaagcaa ccgaagcgat 2617621 cctcattgta acagcaaatc ctggctgcct gctgcagatg aagctcggca ttgaacgcga 2617681 aggactaagc ggtaaagtca gagccgttca cctggctgat ttgctattag aagcagccgg 2617741 gcacaaaaca tcatgagaaa gcccaaaaca gacattgttt tgggcttttg tgcgttattc 2617801 catcggactg caaatttcga tataatgtcc atccggatca gcgatatagg cgaccgtctg 2617861 cccccatggt ttcactttcg gctccccgat aatcgatacg ccttgttctc tcatcctttt 2617921 gatgaccgct tctacatttt cagtaacaaa cccgatttca aatgtgtttg aagcagatgt 2617981 atccggaatg tccagcgccg tgatgtctct ggcgctttcc cgggtattaa gcgccaatat 2618041 cgtagaccct gtatcaaatt cgacatacgt gccgtgttca gcacgaatcg gcagtcctaa 2618101 aatatcccgg taaaaaatga atagcccgct tgctgtccga tacgtataga ataagatatt 2618161 tcattgatag attcattgcc aacccctctc agcattttca atagtccttc tagcccggta 2618221 tagatgcttc catccttaag ctcggatctt tccacatctg cgcccatttt ttcacagccg 2618281 ccacgataat gatgaagcct aacaccagca tgatgataga taatacgcca ttcaatacac 2618341 tatatcctgc tgcttcagga ttgagataca cattgcgcac catccaatag cccgcataat 2618401 tgacagtgac atataaatag gcaagcggga taaggcaagt cagaatgtac cggcgtttat 2618461 cggcgatttt cagcacgatc gtcgctccga taatcagccc cactgaagcc atcagctgat 2618521 tagaaacgcc gaagagcgcc caaatggaac cgatatctcc tgaatacagc aagtaccccc 2618581 acatcaaaca ggcaagcgcg ctggcaaata cagagcccgg aatccagtct gttttcttca 2618641 gcggcttata cacctccccg aagaagtcct ggatcaaata acgggcgaca cgtgtgccgg 2618701 cgtcaatcgc tgttaaaata aagaccgctt caaacataat gacaaattgg aaaaagtatg 2618761 aggccaaatg gctgaaaaac ggcattccgg taaaaatata agtcatccct accgcaagcg 2618821 tgacggctcc ccctgttctt ccttctaagt ccaaaccgat ttccccgctc aattcaggca 2618881 aatgtacgac attcatgcca agcgtacgga aaacctcagg cgtgctgtta atcgcaaagt 2618941 aatcagcagg ctgtaaagcg gtcgctgcaa tcagcgccat gataccgaca agacactcaa 2619001 caagcattgc gccaaacgca accggcttca tatcactcca tttattcagc attttcggtg 2619061 tcgttcctga gccgacaaag gcatggaacc cagagatcgc cccgcaggcg atggttattg 2619121 agatgaacgg ccagacaggt cctgccagca ccggccctcc gccttttacg aattctgtaa 2619181 acgcagggaa cggaatggac ggattgacga caaacacacc aacaatcaaa gcgataaaaa 2619241 caccgatttt cataaagctg cttaaataat cacgcggagc cagaagcagc caaacgggaa 2619301 gcgcagccgc aaaaaacgca taaacaggaa gcgcgattgc aagcgttttc gtatctagcg 2619361 ttaaaaagtc accgagcgcg gtagtctgta cccatggacc gataaagact cctgccatta 2619421 aaaagagaaa gccgaccgtt gaagcgagct ttaaatttcc cgttttctta taaaataagc 2619481 ccacacccat cgcaatcgga atcgtaatcc ccaccgcaaa tgttccccat ggattacgtt 2619541 caagcgcatg caagacaacc atcgacaggc ccgccattgt gatcgtgatg ataaacagca 2619601 tggacagtcc tgtacaaaat cctgcaacag ggccaagctc atccttcgcc acttccgaca 2619661 gcgattttcc gtttttgcgc atcgatgcaa acaacaccac aatatcatgg acggctcccc 2619721 caattaccgc cccgattaac agccacaata atcccggcaa atagccaaac tgcgccgcca 2619781 gaattggtcc gaccagcggc ccggccgctg cgatcgcggc aaagtggtgg ccgaacgaaa 2619841 cccatttatt tgtaggcaca tagtctttcc catcctcaag cgcatgagca ggtgttggct 2619901 tgtcatcatt cactttgaga accttcacca tcataaatgt tccgtataaa cgataggcaa 2619961 tagccaaaat acacattgat gctatcacaa ttgtaaccgc attcattttc tcccatcccc 2620021 ttttctgttt ttcataaata tatcataatt tcatggtgaa aagcggtcat tttttcctat 2620081 acaaaaagcc ggctggaatg ggccggctcg tggcagttga aagacaagcc ggagagaaat 2620141 ctccggcttt gctattctta tgactgtttt ttcaggcgga tcacattcca ggaaagcggc 2620201 gtgaaatgag cagttaagcc gttttcgctg acagacgatg atccgttgga atgcggaacg 2620261 acattttttc tgttatgctg gtttgttgct ttgatatcct gatgctcaag tacgatgtgc 2620321 tctgcgattt ggtaggattc aaagcctctg agcgaaatct ccgtctccat ctgatcctca 2620381 gccttgttta ccgcaaaaat agtgagtgtt tcttcctctt cagagtacac aacagcagca 2620441 tcaacatatg gcacatcagt gaaatcagaa caatcgtact taggagaaga aataagcggt 2620501 ttcagtgact cgccccttcc gtaaacagaa gcatgcatgt atggatagaa aatcggctgt 2620561 ctccatgctt ctccgccttt ttccgtcatg atcggcgcga tgacattaac aagctgtgca 2620621 agacacgcaa ttttcacacg gtctgcgtgc tgcagcatcg taatgagcag agagccgact 2620681 aataaggcat cttcaaaatt gtaaatatcc tctaaaatcg gacgcgcagt gatccacggc 2620741 tcgacttttt tatcagcctc atttgagtgg taccagacgt tccattcatc cagagagaga 2620801 ttgatagttt tcttgctgcg tgtttttgct tttacatagt cacaggtcgc agcgactgat 2620861 ttgataaaat gatccaaatc catagaacgt gccaagtagt ttggcagatt gttatcccgg 2620921 tttccgtagt aagtgtgaag agagatatag tcgacatgct catacgtatg ctcaagcacc 2620981 ttcgcttccc aatcgataaa ggtcggcata ccgctgtttg agctgccgca ggcaacgagt 2621041 tcaattgatg ggtcaaccca cttcatgacc tttgctgtct ctgcggcaag ccgtccgtat 2621101 tcatcagctg ttttgtggcc gatctgccat ggtccatcca tttcgtttcc taagcaccat 2621161 gttttgatgc catacggctg ttcatagcca tgcgatcttc ttaaatcact ccagtaagag 2621221 cctttcggat ggttgcaata ttcaacgaga ttacgggcgg catctatgcc tcttgtgcca 2621281 aggttgacgg ccatattgac ctcagtgttc accttttttg cccaagataa aaattcattt 2621341 gttcccactt cattggtttc tgtcgtttgc catgccaagt caagccgtct cgggcggttt 2621401 tcgactggtc cgacaccgtc ctcccagttg tatccggata aaaagtttcc gcccggatag 2621461 cggatgatgg gaacctgtaa ttctttgatc agcgactgga catcttttct aaatccatct 2621521 tcatccgctt cagggtgatc aggctcgtat atgccttcat ataccgcacg acccatatgt 2621581 tcgataaacg agccataaat ccgtttatct acttcaccga ttttatattc tttgtctaca 2621641 atcattcgcg cttttttcat cacacgtttc ctccttcatt aacctttgac tccccctacc 2621701 gtcaggccgg agataaagta cttttggaaa aacaagaaaa tgataatcac cggcaaaatc 2621761 gcaaatactg agccggatat aagcatgtcg taattatttc cataagggct cagcaagctg 2621821 gacagcccta ttggaagcgt aaacatttct ttcgaccgaa gcacaatcag cggccacaag 2621881 aagttgttcc agctgtttaa ggactgaagg ataatcatcg caccgaaagc cggtttcatc 2621941 agcggtgcca taatcctgaa aaagatgccg aattccgtac agccgtccat ccttgcagag 2622001 tccagcagat ctcttggaag gccaagagca tattgcctga aaaagaaaac agcaacaggt 2622061 gaaacgataa acggcaatat gacacccgta tatgaatcga tcaagtgcag tccgacagta 2622121 agtttaaaca gaggaagcat catcacttcc agcggaacca tcataataat cagcacaaga 2622181 acaaagatga tatttctgcc cttaaaatca taaaccgcaa gcccgtaccc gatcatcgaa 2622241 gaaaaaaaca gagtgagcac agtcgtaaaa agtccgagta caagactgtt aaaaaaccat 2622301 ttgaaataaa tgctgccgcc attaaacaga aatgtgtagt tatcaaaact catcactttt 2622361 ggatcaatat caagattcag ccccacacgc aaaagctcag atgacggctt taatgatcct 2622421 aaaagcaaac agaaaatcgg aaaaagatac aataggctca gcatcataaa aaacagggtc 2622481 agcgcaattc tataaacgct aaactgagga ctgtgccgca acatttatcc ctccccctta 2622541 aacgagcctg acagctttaa tgaaatcagg ctgacaacaa ggatcacaat caaaagcaca 2622601 atgccgatgg ccgctccgta tcccatttca ttgtaggcaa gtccctgctg atacaaatat 2622661 ccgacaagcg tcagaccaat attacccggg gaattattct gccaaaggac gtagctttcc 2622721 tcaaacatcc tgaagccgcc gatgatgctg atggtcagca catatacggt tacaggcttg 2622781 agaaacggca gcgtgatgtg cagaaatttt ttcattgtat tcgcgccgtc tatatcagcg 2622841 gcttcgtaca gctctttcgg cacattttgc aaacctgcta aaaagtaaag gatgttgatt 2622901 cccatccatc tccatgaagc aagcagcacc atcaaaaaca tgccggtatg ttcattgttc 2622961 atccagttct gaggtgaaaa gccgagttta agtaggatgg aattggccag agacgtttcc 2623021 atttctccga agatcagccg aaaaatgatc cccgcgacaa tggttgaggt caatgccggg 2623081 ataaataatg ctgatttaaa tatatttcta aatttgacca gctttgaatt caggaatatg 2623141 gccagaagca atggaacagg aatcagcacg atcagcgtcc aaaaggtgta ttccagcgta 2623201 ttccaaaggg cggtatagaa cgtcgggttg tttagcgctg tataattaga caatccgaca 2623261 aaggacacct ctcccggcaa aattctttgg aagctcatga tgaagacact aatgatgggg 2623321 tatagaaaaa atacgagaaa ggataaaacg aatggcgctg taaacagata gggcgccgct 2623381 ttttttgaat aaaacagatc tcgccagcct gattgtttcg cagctgaagg aacgggatga 2623441 accgttcccg ttttcacagg tttcatgaga acctccccgc tttcactttt tgaatgggat 2623501 tctatttctg tttcagttca cctgccgctc tgtccaaggc ttgtttaggc gttttttgct 2623561 gagatttaag cgcgtcgaac aatacgcttc tgttgacaag gtctgaagcc ttggcaaaat 2623621 cctcatgtaa ataaattgga ttgatttcat ccttgatatc gagcagcaca gaaaaaatgc 2623681 ctgttccgtt ttggaagtaa tccgtgtatt tgtttttctc tttcaattcc ttggagctcc 2623741 aaacatccca gcgaagcggg tcaaagccga gtacgctcca gagtttttta tttccttctt 2623801 cagagccctt cgcaaaggcc aaaaactctt ttgctaactc aacatgcttg gattgcttcg 2623861 gtacaacagt tgccgtaccg cccaaacctg ccgagcggtc gcccccctct ttccatgccg 2623921 ggagcggtct gatggcaatc ttccctttca gatcaggcat ataatcgata aatcttccca 2623981 tataccaaat cggcatgaga actgaagcag ctcctccttg gttcataaag ccgtagtatt 2624041 cttcactgtg atgcccgccg cccggcgcag gaatcatcgt tttatcattg atcatgtctt 2624101 ttaaatattg aagtgttttt acgttggtgt cattattgag gatcagcttg ccgtttttat 2624161 caaaatagcc tgagttttgc tgtgaaatca tagataagaa cgttgcggaa tcatttgttt 2624221 ccaccgttcc catcggcttc ccggtcactt tgcgcacttt ctgtccggct ttatggtaat 2624281 catcccatgt tttaatatcg tcaggattga cgccggcttt tttcatcaca tccatgttat 2624341 aaaacatgac cgttgtccct acatgtgtat cgagtccgta aagctttccg tttttgctgt 2624401 acaatgtcag ccgcgcctca acgaatttat cgcgatcctt ttcaatcagc ggagtcaagt 2624461 cggcaagcgg tatgtcagag cccttcaaaa agtttgaaaa acgggccaat tcgacatctg 2624521 caatatcagg aacgccttct cccgctatta gggagataga taagttatcg tgcatttgtc 2624581 catatggata aacgaccgta ttcagcttaa ttttgcggtc aggatatttt ttgttccatt 2624641 ccttcaccat ttccacatag aactgctcat gaagcccgtt aaatgtccaa aaggtcagct 2624701 cagtttcacc cgatttgccg gatgattttt ctgctgaaca cccggcaatg actaatgtca 2624761 gcaacatcat gagcacaaga aaacagacag tcattttttt catctgcgtt accccttcca 2624821 ttcgaggtgc gggctattca tatagaccat ggttgatcag cgttttgttt tcattgatga 2624881 ttcttaatcc ggtgcatcgg tctcttaagg tgtgcgcgtg tctgaaggca tttttgacgg 2624941 aatcctgccc gacaccgatt tcgtcaaaat acgcagggcc tccggctgat ctcagccaat 2625001 cagccagcac ttctcctctc gggagtgttt gataagccga ttggatggct tcccggcggc 2625061 ttggtgaaaa ttcgttcagc ccgtcatcct gagcgagctt tctgtatgtg tcagttaata 2625121 aaacagcggc acagcccacc tttgccccat gaagaatctg aggccgtttt ttctccatta 2625181 actccatttc aatccaatgt gaaatatgat gctcgccgcc tgatgccggt cgggaatgat 2625241 ctaatgccag catgacaagc cccgatacaa gtaaagactc catcaaaacc cgtatgccag 2625301 tttccgtttt catcgcaatg tcttctgtgt gttcaatgca ggcagcaagc gcctcctgaa 2625361 cgatcttagc tcctgcaggc gaataaggct caccggcaag atgccgggat atttcccaat 2625421 ctgctaaaga cgtgatttta ccgagcatgt caccaaagcc agccgccacc attgactgcg 2625481 gtgccgcttt taatagatcc agatcagcga acagcgcaga tggggccttc gtttgaatgg 2625541 ttgttttcgt gccgtataaa ataatcggcg caccggctga tgtaaaaccg tctacagatg 2625601 gagcagtcgg ataagaaata aacggcaaat ctctttgaaa cgccgcaaag cggacgatat 2625661 catgaatcgt gcccgaaccg actgcgatca tgacatccgt tggttgtttc gtatggatca 2625721 gcacatgaat gagcgatcgt tcatcagctg tcacatctcc ggcttcattt tctggaatga 2625781 tcaggcactc ggcctgaaat ccttcttgat tcagtcggtt ttctaaatca attcctgcaa 2625841 tgcggtgtgt attcgcgtcg cagacaagga caatatgttg attgtttttt cgttttacat 2625901 aatccaaaag cgaatcagct gcttgcttac cgagaacaat ttcttcaact tttataggca 2625961 acgtcttttc tccggcgttt tcaaaagcac gctgaacgtc agctgcgata cgattcatat 2626021 cagaatcccc tcctcagcca atttggttac atccttaata gaatccagca cataatccgg 2626081 cgtgtacaaa cgctgttcac cctgtttcgc agaaccagtt agcactaagg cgcttttcat 2626141 gccataaagc ttccccatcg caatgtcaga ttcaatgctg tctcctataa tcatgcattc 2626201 atgtgcggac agccccattg ctgtacaggc agcctccgcc atcagccatg acggttttcc 2626261 gacaacaagt tcagtcttcg cttgtgcaga agtctcaatt gccccgatca ttccggccac 2626321 atcaatggca tttccgtctt cgttcggaaa agagcggtct ttgtttgtag cgataatacg 2626381 agcgccgccg gcagccgctt gaaaggcttg atttaaatcg tcgtacgtga gcgtttcatg 2626441 aagggagatc acgagccaat ccgcttcctt cggttcgctc gcgttctgca caccggccag 2626501 cctcagctcg tcaaccaagc cttgctcccc aagcacccat acctttgaaa aacgataatg 2626561 ttttttcaga aaagccgctg tcacgcttga tgacagaaca atgtcgttta cgtccgtttc 2626621 aatccccgcg ccaagaagtt tttttctgca catggcacgg gagatattcc cccggttgct 2626681 taaaaagacg attttctttc ccattctcct aagcgttttg atcgcttctc ttgctccttc 2626741 gatcaactca tttcctctga atacagtacc gtccaagtca atcagaatgc cagccggtga 2626801 cacaggcgta tcatgactgg ccataatacg catttgctcc gtgttttcga taaaaatgct 2626861 tttcatgcag gactgtattg attggggtta catccttgtt cagcataatg gagtgatagg 2626921 ccatttcggc aaccgtttct aatacaactg cgttatgaat ggcatttaag gcgtcagtgc 2626981 cccagcagaa cggtccgtga ttattcacga gcacacccgg cacctgttcg taattatgat 2627041 gctgaaaggt ttccgctatg acttttcctg tattcagttc gtagtcatga atgatttctt 2627101 catcgtacat ttctcgagta catggaatcg cactgtcaaa ataatcagca tgggtcgtgc 2627161 ctaacggagg gatgtctctg cccgattgcg cccagcttgt cgcccattga gaatgggtat 2627221 ggacaattcc cccgatattc ggaaaggctt tatatagata aacatgggta ggtgtatctg 2627281 aagaaggttt aagcgagcct tcgacgacct ctccatcaag gttcaaaaca accaagtcat 2627341 cggctgtcag gtcgctgtat tcgactccgc taggtttgat gacaattctt tctttttcac 2627401 ggtcaatgcc gctgacattt ccccacgtaa aggttaccag ctgatgctct tgaagcttca 2627461 ggttggcagc cagcacttct ttttttaatg tttcaagcat gctccatcac cctttatcaa 2627521 ttctttttgg cggcagatga aaattgaaga tttttgatcg ttttcagacg cttcatgaca 2627581 tggttttctt ttccgaaata atgaaccagc tctttatatt cagcgtacaa tttttcataa 2627641 accgcggcgt tttcggcatt tggcgtataa gttatatctt tcagttttcc catgttcgcc 2627701 gctgcctttt tgatatcatc gtagccgcct ttttctttgc ctgctgcaag cgcgccgaaa 2627761 atggcagatc ctaaggctgg ggcttgcggt gaaccagaga ttttaatgtc catgtttgtc 2627821 acatccgcat aaatctgcat gacaaacggg tttttctcag ctattccgcc ggctgcgaac 2627881 agttcctcaa tcggaacacc gctttctttg aatgtttcga taatcatccg ggttccgtaa 2627941 gctgtcgctt caactaacgc tctataaatc tcttcaggct tcgtcagcag tgtcatgcca 2628001 agcagcatcc ctgttaaatc tgcatcaaca agagttgaac ggtttccatt ccaccaatct 2628061 aaagcaagca agccgctttc accaggcgct tgatggtttg ctttctcact cagcagctca 2628121 tgaacgccaa tgtttttttc ctttgcttcc tcttgataag ctggcgggac acatgttttc 2628181 acaaaccagt caaaatgatc gccgacacag gactgcccgg cttcatatcc cgcatagccc 2628241 gggagaattc cgttgtccac aacgccgcac attcctggaa cgatatgcac ctcttcacca 2628301 agtagaacat ggcacgtcga ggttcccata atcatcagca ttttccctgg ctctgtaatg 2628361 ccgaccgccg gtaccgaaac atgagcgtcc acattggcaa ccgcaacagc cgttcccggg 2628421 agaagccctg tcagctttgc cattttttca gtcagactgc cggctttttc tcctactgaa 2628481 tgaatagaac ctgacaattt gtcctttgta atcgttttca ttgaaggatt taatttctca 2628541 aagaaatcat ctgacggata ccccgctttt tcactccaca tcgctttata ccctgcggta 2628601 caattgcttc gcttgagcga gccgcacagc tggtacacga tccagtccgc agcctcgatg 2628661 atccggtcag ccgcttcata aatgtgaggc gcttcctcgg caatttgcat gacctttgga 2628721 atcatccatt ctgatgaaat ttttcctccg taccgctgta aaaaagcctc tccttcttct 2628781 tccgcgattt gattgagccg atcagcatgt ttttgggccg catgatgctt ccagagcttc 2628841 acatagctgt gcggctcctc ttcatattca ggcagcatgc ataacggctg cccgctgctg 2628901 tcaataggaa ggatcgtaca tgccgtgaaa tcaattccaa tcccgataat gtctttcggg 2628961 tcaacgcccg tctgttcgag taaagacgga atggttgttt ccaagacttc gaggtaatca 2629021 gcagggtgct gcagcgccca gtcacgcggc agcttttgac ccgtttttgg aaggacggta 2629081 tcaatgacag catgcctgta ttcttttaca gcagccgcaa gttcctcccc tgtttggaca 2629141 tgaacgagca ctgctcttcc tgataaagtt ccaaaatcaa cccctattgt gtaagccatg 2629201 tgacatcccc ctctactttt gaagccggta aagcgcctcg ttccatttta actcgtgttt 2629261 cagtttatga attgtcgtat cacgggaaat gagaacactt tcgattcccg ccatttccgc 2629321 ccaatcaagc atttgctccg ctgtcagttc ataagacagg caggtatggt gtgcaccgcc 2629381 ggctaaaatc catgcctccg ctgctgtttt caatgacggc tccggcttcc agagaacacg 2629441 ggcaaccggt aaattcggca tgtctttttc aatttcctgg ccgttgactt cattcagcac 2629501 aaggcggaaa cgcccgccaa tatcaacaat gctagcttga atggcagaac cgctgatgcc 2629561 gttaaatacc aaacgcgcag ggtcctcttt gccgccaatc gaaagcgaat gaacctcgat 2629621 tttcggctga tccaaagcga cagtcggaca cacttcaagc atgtgagagc ccagaatcat 2629681 ttcatttccc ggttcaaaat ggtacgtgta atcttccatg aaggaagttc tttttccttt 2629741 agccatgatt ttcatcatcc gtacaagggc cgctgtcttc caatctcctt caccggcaaa 2629801 cccatagcct ttctccatca ggcgctgaac ggcaagtccc ggcagctgtt tcattccgtg 2629861 cagcacttca aacgatgtcg taaacgctgt gtatccgcct tgctcaagaa aagcggttaa 2629921 tccaagttca attttcgcct gttctttaat ggacgctacc tttgcttcgt cacgttttgt 2629981 ttcctcactg atcacatata gtctgtcata ctcggcataa agcgtgtcaa cctcgtcgtc 2630041 cgtaatgcga tccatcactt caacgagatc cccgatgcca tatccgtcaa cctgccagcc 2630101 aaattgaata tgcgctccca ccttgtctcc gtccgttacc gcgacatgac gcatgttatc 2630161 tccaaatctg gcaaccttaa tatgtctgct ttcatttaat gcagccgccg tatccatcca 2630221 ctgggacatt tcttttttca cttcttcatc atcccaatag ccggcaatga cttttcggct 2630281 aagccccatt ctcgagttga tgtaaccgta ctctcgatcg ccatgcgcgg attggttgct 2630341 gttcataaaa tccatgtcaa tcgtacccca cgggatatcg cgattatatt gggtatgcaa 2630401 atgcataagc ggtttttgat aagaggaaag gccttctatc cacatttttg caggggaaaa 2630461 tgtgtgcatc catgtaatga tgccagcaca tgtctcactg tactccgctt ctcttaacag 2630521 ctctctaatg gtttccggtg aagtgacgac gggcttatga gtgattttat atctggaaga 2630581 aatcccgctg agcccctcac aaatgctttt agcatgctga tctacgagtt ccagcgtctc 2630641 ttccccgtat aggtgctggc ttcctgtcac aaaccagaat tcataatcct ttgtctgaag 2630701 catgtaaact gcccctttct cataaaataa aacgctttca aatacaaaag atacgtacta 2630761 atgatagaaa ataaacctat aaataaatat ttgtacgaac aattttatta tagtaattga 2630821 ctattatact gtcaatcttt tcttttaaaa aaagccgggg gcagagcccg gctttttaat 2630881 tcaataggac ggccagcccg agctccaatt caaatcattg atgagaagct ttggaatgcc 2630941 gttgtcattg gcatcatagg catggcgaac aagaatgttt ccgttcacaa tatcctggcc 2631001 tccaggtcct ttccattggt cattgcccga atccaaaatg gtgcctccgc cttcaagcat 2631061 gctttttccg cttttatcaa gataagggcc tgtaatgctt ttggatcttc cgtaagcaat 2631121 tttgtacgta ctgtttaccc cgtcacagca tttatcaaat gaaaccatta aatagtaata 2631181 tccattttga tacgtaagag taggagcttc taaggcacct ccattattcg gtctagctgc 2631241 aatcgaatag agcgagcctg taggcttcat tgtactctta tcgagcttag tcagcttaat 2631301 gccgctccaa aacgagccga atgcaagcca cgggttgcca tccttatcga atgtcagctc 2631361 cggatcaatg gcgttataat tatttgagct tgtcgaacgg atcaccaagc cctcgtcctt 2631421 ccagcccccc gaactgatgc ttgttgaaga tgccaggcca atggcagatg tattgcttcc 2631481 aaaagaagaa acggaataat atagccagta cttgccgtta tagtattgga tgtccggcgc 2631541 ccactggttt tggccataat tcggcacata attggaccac cacgatagcg gtgtagtgaa 2631601 aatggatttt tgtacggtcc aatttttagc gtctgaagac ttcaaaaccc gcagtccccg 2631661 ttcttcagta agccctgttc cgagcgcata ccatgagctc ccctctttaa tcatagtcgg 2631721 gtcatgaagc agctcattgg atgcacccca aaacgctgcc tctgcgggag cagcagaagt 2631781 gaatatcaaa cctgcagcca gagctgcact cgaaaagtgt aagaagcgtt tccatgtttt 2631841 tttctttttc aattttgttc aacctccttt attttagaaa gcgcttacaa attagattat 2631901 ttatcctccc ttcctgtcaa atcgactgcg tatcgtatat cgtcatgttc aggaaatttt 2631961 cggtatcccc tttattgtag tcactatgct gtaatttgta cagacaaaaa aatagaatcc 2632021 acctcaatag gcggattctt ccgtatcttt attggtacgt aatttcgtca accgtttttc 2632081 ggtctaactt cttaatgact tctgtaatta actttaccgc gttttcataa tcatcacgat 2632141 gcagcatggc cgcgtgcgta tgaatgtagc gggttgcaat ggtaatggac agcgcaggaa 2632201 cgccatttgc cgtcaaatgg atggcacccg aatcagttcc gccgccggca atggcatcaa 2632261 attggtacgg aatgccggct tcctccgcag tggctacaac tgcatcgcgc aaacctttgt 2632321 gagagaccat ggatgcatcg taaacgataa tctgcgggcc tttgcccatt ttgctctgcg 2632381 cttccttctc ggaaatgcca ggcgtgtctc ctgctatccc tacatcaaca ccaaacgcaa 2632441 tatcaggctg aatggtgtgt gcagccgttt tcgctcccct cagcccgact tcctcctgca 2632501 cggttccgac gccatacact atatttggat gatctgtgtt ttgtaagttt cttaacacat 2632561 caatagcaat cgcacagccg atgcggttgt cccaggcctt tgcgagtagg aatttttcat 2632621 tgttcatgac cgtaaattca aaatgcggaa cgatcatatc tcccggaagt acaccccact 2632681 ccaaggcttc ttcccggctt gaagctccaa tatcaataaa catgtctttt atttccactg 2632741 atttttttct tgcttcagga gacaaaatat gaggcggctt agatccgata acccctgtga 2632801 tttctccttt ttttgtgaca atggtgacgc gctgagcaag cataacctga gcccaccagc 2632861 cgccaacggt ttgaaaacgg ataaagcctt tatctgtgat ttgtgtcacc ataaagccga 2632921 cttcatccaa atgtccggcg atcataattt tcgggccgtt ttctgcacca gttttttttg 2632981 caattaaact gcccaggcga tctgttgtca cctcatcagc aaatggttct atgtatgatt 2633041 tcatcacttg ccttacttct ctttcattgc ccggtatgcc ttttgcatct gttaaatctt 2633101 tcagcatggt caatgtttca tctaattttg ccatgttcca aaccctcctt catcagtcct 2633161 gcattcttat tatacaaaac atggcgctaa ccatacgact atttcacttg aaaatcgggt 2633221 atatgttttt acagctttct tttagaaaaa gtgaaacctt tttctatgct tttcgtatta 2633281 catcagatca tcaccataag ggaggtgcct tcacacaatg tttgtcatgg ttctaaggat 2633341 tattttgctt gcactttttg cttattgtat ttatgccgtg gtcaaatatg tcgcgaatcc 2633401 taagagaagg cttaagctgg cccaatcaaa agaacatttt tatattattg atgaacaaaa 2633461 caatacccgg aagaattttc agctgacgta taaaggcgtg ctttttgagg gagaaaagca 2633521 tattccttcc aaggatcatc cgctgtttat tcacacgatc tttgtctgga cagaatctcc 2633581 tgagaagctg aaacatttct ctgcaaaaga ttttgagaac attgaagaaa aagtgctgga 2633641 acgatatcca aattgtaaga ttgactggga ccagcccatt aaactcgcaa aaaaagcaga 2633701 agagcgttaa acgcttttct gctttttata aatcaaacgg gctgtagtaa atagcgatga 2633761 gaatcgcttc tattaccaga agaagcggta ctccgtactt aaaagaagcg tgtttcgttt 2633821 tatgtctgaa ggtttgcatg ccaagccaga caccgagcgc tccaaacacg atggctatca 2633881 gccacagccg gtcttcagaa attctccact tgtgctgctg cgctttgcgt ttgtcaatgc 2633941 ccatcaccca aaaaccgcac agattaatca acaccaaata agcagcaata atcatgttgc 2634001 ctcatccttt atatagaaaa agccgctctg ctggagagcg gctctatatg attacttgtt 2634061 taattgagct ttagcagcat cagcaagctg attgaatgca gtaagatcgt ttacagcaag 2634121 atcagcaagc attttacggt ttacttcgat accagaaagc ttaagaccgt gcattaaacg 2634181 gctgtaagaa aggccgttca tgcgagcagc tgcgttgata cgagtgatcc aaagtttacg 2634241 gaaatcacgt tttttctgac gacggtcacg gaaagcatag tttccagatt tcatgacctg 2634301 ctggttagct actttgtata atgtatgttt tgaaccgaaa taaccttttg ctaatttaag 2634361 aaccttttta cgacgcttac gtgtaacagt tccgcctttt actcttggca ttgaatttcc 2634421 ctcctaattg ttccttatcc gattacttga tgttagcaag catttgtttg atacgtttga 2634481 agtctcctgc gcttacaaca gcactcttgc gaagcttacg cttttgcttt tgagatttgt 2634541 tggcgaataa gtgacttgtg tacgcgtgag aacgttttaa cttcccagaa cctgtctttt 2634601 taaaacgttt agcagatccg cggtgagttt tcatttttgg catgggattt cctccttatt 2634661 gcttttcgtt tttcggtgcg agcattaaga acatgctgcg gccgtccatt tttggttttg 2634721 tttcgactgt cgcaacctca gcacatgctt cggagaaacg gtctaataca cgctgaccga 2634781 tttctttatg agtgattgcg cgtcctttaa agcggataga agctttcact ttatcgcctt 2634841 tttcaaggaa tttaatcgca ttgcgcaatt tcgtgttaaa gtcatgctca tcgattgtcg 2634901 gacttaaccg aacttctttt aagttaatga ttttttgatt cttgcgtgct tctttttcct 2634961 ttttctgctg ctcaaatcgg aacttaccgt agtccatgat tcggcagaca ggcggttttg 2635021 cattcgctgc aactaacaca aggtcaagat ttgcgcggcc ggcgatttca agtgcttcct 2635081 gacgggactt gattccaagc tggtcgccat tttgtccgat taaacggacc tcacgtgcac 2635141 ggataccctc attaaccaat tgatctttgc taataatgag ccacctccat agtttcttcg 2635201 aattgattca caactcattt tgaatgcatt ttgcaggcaa acaaaaagtg tgggcattat 2635261 aaaacaccca cactacgaac atctgtatca ataaaaatgt acggtcaacc tgccaactac 2635321 atgcatgtgt caatcaggtg agaagcgggt gcttctgctt gtgatttata ttcaattcaa 2635381 taactattct acacaatacc ggatctttag tcaaggacga cttatccgga acaactttta 2635441 cattgtaaca tgggttttct atgagcgcaa gagagaaaaa gaaaatcttt catccccacc 2635501 cagaatacaa agaaccaaca attccccctt attacgcaat ttacaacaaa accaccgaca 2635561 ggaagaaatg taaaacaaag ttaatctctg accgatataa ggagcagaag ggagcctgac 2635621 acatgaacaa actgatacag cttgctttat ttttcacatt gatgttaacc ggttgctcga 2635681 atagcagcac atcttccgaa tcaaaagtcg aaaccactgt taagacaacg gcagcatttc 2635741 ctcaaaagga gctggagaaa gagctaaaaa aactaaaacc cgtttcattg gacatgaagt 2635801 tcgagagtcc actcgctacc gagttaggaa agcggaaggc aaaagaggaa gctgaaaagc 2635861 aaagacaaat cgccgctgag aaaaagcttg aaaaagagcg ggaggcgaaa cgaaagaaac 2635921 agcaggagga aaaagcggag agacagcgat tagcagagca gcaggctgca gagagacagc 2635981 gattagccga agcggaaaga caagctgaac ttgaaagaca gcggcaggca gcaatccaaa 2636041 aagagcagaa agcgaacgct gagaaaaagc ggcaatcgca ggcacaacgg cagcagactg 2636101 aggcaccctc atctaatagt caagatccac catcttcctc gagtcagaca gataaaacca 2636161 ttcaacagcc agcttcagag cttcctgatg acgatggtta tggttatgaa gaacgaaaaa 2636221 agtggcatga cgatcaagta gaatggggca ttaaacaagg gtatatcgat cccgaagacg 2636281 caccataaaa taaaaaaagc caaggcattc agccttggct tatcctccga tcagctgcac 2636341 gaacacaggg atgaccagaa ccgttaccac tcctactacg acaacagcaa tacttgccat 2636401 cgcagcttca acttctccca tctcaatccc gaccgctaca ccaagtgcat gtccggatgt 2636461 tccaagagcc aatcctttag aaatcggatt tttcacttta aacaccttca agaacaatgc 2636521 tccgagcgca tatacgatga cagcgttaaa gatgaccgca aaggctgtga tgtcgctgat 2636581 gcccccgatg ccttttgata aaggaagcgc aattgccgtt gtagccgcct gcggaagcat 2636641 gcttttcatt acggccgaat cgagatgaat gcctttagcg agcagataaa caatcgtgac 2636701 agagcagata gagccggcaa taatggaggc catgatttgc caccagtact ttttaagctt 2636761 atctctttgt ttgtacaaag gaattgcaaa tgcgatcgtt gccggttcaa gaaaaaactt 2636821 aatgatctct cccccgttat tataatccgc gtaggaaaaa ccgccgattt ttaaaaatgc 2636881 gatccccagc accatggcaa caaacaaagg agtgaaaagg aagaagcctt tcgttttctt 2636941 aaataaaaag gtgccgatgc cgaatgcagc aagtgatacg acaatcccaa aataaggact 2637001 cattgtgctt tccatgtgaa gaacctcctg tttcccttaa tggtgaacga gttcgttatt 2637061 gttctgcggg ctttgcactg tttttgtttt catgtccgct tcggttttgc gttttccgct 2637121 cagcgacaga atcagctgag aaaacaatcc cgtagccccc agcaaaataa tcgttgcgag 2637181 cagaatgaca agaacaattt gcaggccgta ttgctgcatc acaccaagcg aattcataac 2637241 agatatacct gatggaacaa ataaaaatcc gatcagagag gttaaagacg ttccgagcgt 2637301 ctccacttgt tccagtttaa tgactttcaa acataatagg agaaataata agaccaaccc 2637361 tacaaccgat gccgggatag gtattgggac aatagcggca atcatatttg aaaccagcat 2637421 aatgacggca aaaataaatg cttgtgttaa aaacccgtac acttttttag cactcatttt 2637481 cttcacctct ttctctttgg taccctcatt ataaataaga attccctgtt ataaagcgct 2637541 tacaagataa catgccgtat agcgggtctg agttgcagaa tcaaatggct gaaatgcaaa 2637601 aagccgccca tcaaatatgg agcagctttt tcaattcctt cgcatatgtc cggctgaccg 2637661 gtattttcga tccgtctttc atgatcagat tatacgttga attaaaccat ggctgaattt 2637721 ctttaatata ttcagtattc acgacaaagc tccgatggac gcggataaaa tcagaatccg 2637781 gcagcttttt ctcaatcaca acgagtgtat cgctgaccgt ataagaatga tcgaaggttt 2637841 ttacattgac atgaccatct tctgttccgg catagataat gtccttcgta tccacaatca 2637901 caatcgattc ccccacagat agcgcgagct tgtgctggcc ggcatggctg ttttgctctg 2637961 tttctacaat atcccgattg acttttttat attttttcag cgtttgctga attctttctt 2638021 catcgaaagg cttggttaaa taatcaagag cgtccacctc aaacgctttg agcgcatact 2638081 ggtcatacgc tgtcgcaaac acaatagcag gaggatgctt cattttcttc aatcgctttg 2638141 cgatatcaaa accgttttct ccggataaat caacgtctaa aaacagcaaa tcaggttttt 2638201 gatccatcat ttggtcaaaa gcggattcga tattttccgc ttcattgatt tccatttcat 2638261 cattggtccg cttaagcaag taagccagtt catcccttgc cagcatctca tcatcaacta 2638321 ttaacaccct gagcatgttc ttctccctct ttcatctgtt gcattggcac ttgaaaggaa 2638381 acctctgtcc ctttatgaac ctcactgctg atatgcagtg cagcctgctg tccgaataaa 2638441 ccgatcagcc gctgatttag gttataaagc gctgtaccgg ttccctcctt agacggaaac 2638501 ggtttcttcc ccagttccgg caagacgtcc ggcggaattc cgcgtccgtt atccgccacc 2638561 ttcatataga cggatgcatc atcagataag acacagactg taaccttgca tatgtcttgt 2638621 tttttcggaa acgcgtgccg aagcgcgttc tcgacaagca cctgcaaaac aaacggaggg 2638681 atttcaatct gctccagtct gctgtcgata ttaagctcaa ttttatattt cccgggaaaa 2638741 cgcgcctgtt ctaatgacaa ataggcgtta agatggttca gctcctttga gagcggaatc 2638801 agcagctgtc tcgctccttg aaggtttgaa cgaaaataaa cactgagctg caataggagc 2638861 ttacgggttt tttcaacatc tgtacggcat aacgcagaaa tcgtgttgat cgcattaaat 2638921 aaaaaatgcg gattcacctg tgcttgaagc gctttaattt cagcatcctt gagaagtttg 2638981 ctttgcagct ctgcttcccc aagctcaagc tgtgtcgaaa acagcatggc cagcccctcg 2639041 gcaagttcct cctctacctg actcaggcct gccgggcttt taaagtacat ttttaaggtg 2639101 ccgattgtat tgccgttcga tgtcagcggt aggacaattg cagcgtgcaa agggcattca 2639161 gcatgcgtgc attcaatctc ttcctgcgaa atcgccttca taatatgccc tgttttaatc 2639221 acctttttgg acaggccggt gatcaagctt ttcgatggga tgtggtgatc cattcccgca 2639281 ccgacatgcg caaggatctt ttctttgtca gtgagagaca ccgcatctgt tcctgtcagc 2639341 ttatggataa tagccgctac acttttacag gagttttcat ttaatccttg gcggaaaaat 2639401 ggaagtgtct gatcagcaat cgtaagcact cgatgcgttt cgagagccct tgcctgttct 2639461 tccttgcgaa tgatcgcttg aataatagac agaaaaataa aactgcctgt tccattgatg 2639521 agtatcatcg gaattccgat catgctgaca agctcccaag cgtcactgaa cggctttgcc 2639581 atcagcaaaa taatgatcat ttgcagtgac tccatgccga ttcccacaag agcggcgatg 2639641 cgcggtgtcg gcattcgata tcgcttcgta aaatacctgc cgatcaagcc tgcaagaaca 2639701 cccgctaaaa tagatgagac ggcacagctt aaggccgtgc tgccaccgag tgaaaaacga 2639761 tgcaggcccg caagtatgcc gatcccagcc cctacaaaag gacctccgag aaggcccccg 2639821 atttccacgc ccaaaatacg ggtattcgcg atagagcccg atggatctat cgtaaacacc 2639881 cagtcattgt ttacaatcat atttctttga atttcgatgc ctgtataatt gctgatgatg 2639941 ctgaaaagag aaaaaataga aattaaaatc gcttttcctt tatagccgtc ctgattctga 2640001 agagcttgtc tgaaaagttt cgtatgggcg agaatgaacc ctaatataac aataatcccc 2640061 actctctcca gcatcataat cattaaatga atcattcatg tcacctgttc tttccgtttt 2640121 cattctagca tgttttcgtt ttgcggctga ctgttttttt aaaatcgtct gaaaacatat 2640181 ttcacaaggc ttttatctat tgtaaaataa aacatgagcc ttttggcaga aagatttgaa 2640241 tctgaagcag aggagaagat catgaaagcc gtattttttg atttagatga tacactactt 2640301 tgggacgaaa aaagcgtcag aacaacattt gcagaaactt gcttacaggc ggagaaaaaa 2640361 tatggccttg cccctgagga attcgaagca gctgttcgcg aagcggcgag agaattgtac 2640421 atgtcatatg agacgtatcc atatacagtg atgatcggca ttaacccgtt tgaaggactg 2640481 tggtccaatt tctcagagcc aatcagtgaa ggctttcaaa agctgaacaa gattgtgccg 2640541 gagtacagaa gaaatgcatg gaccaacgga ctgaaagcgc ttgggatcga tgatcctgca 2640601 tatggcgaat acttgggaga gttttttgcg gcagagcgca gaaagcgccc gtttgtatat 2640661 gatgaaactt ttgctgtact cgatcaatta aaaggcaagt atgaattatt gcttttgaca 2640721 aatggcgatc ctagtctgca aaaggagaag cttgccggcg tgcctgagct cgctccttac 2640781 ttcaatgaaa tcgtcatctc gggcgcattc ggcaagggca agccggatgt ttcaattttt 2640841 gaacactgcc ttaagctgat gaatattgaa aaagacgatg ccatcatggt cggcgataat 2640901 ttgaatactg atattttagg cgcttcaaga gccggaatca aaaccgtttg gatcaaccgg 2640961 actgataaga aaaacgaaac tgacgtaaag cctgattaca tcatcagcag ccttcatgat 2641021 ttgtttccta tattagagaa ataaaaaaag catgatctct tcaatgagat catgcttttt 2641081 tattttattt tttcgcttca gctactgcct ttttcacaaa ctcatcaagt gaaatggttt 2641141 cagagttctg ttctccgtat ttacgcacgt ttaccgctcc gttttctgct tcttggtcac 2641201 cgaccaccag catgtacggg attttttgca tttgcgcttc acggattttg tagccgattt 2641261 tttcatcgcg gctgtcgact tcaacacgca ggccttcaca ttgcaggcgt tcctgcactt 2641321 ttttcgcgta gtctaaatgc acagccggag aaaccgggat gacttggaac tgaaccggtg 2641381 caagccatgt cggcagcgcg cctttgtgtt cttcgattaa gaaagcaaca aagcgttcca 2641441 ttgttgaaac gacacctctg tgaatgacaa ccggacggtg ctgcttgccg tcctcaccga 2641501 tgtatgtcag gtcgaaacgt tccggcaata agaaatcaag ctgaaccgta gacagtgttt 2641561 cttcttttcc gatcgcagtt ttcacctgaa catcaagttt aggtccgtag aatgccgctt 2641621 caccttctgc ttcgtaatag tcgtggccga tttcatccat tgcctctttc agcatggatt 2641681 gcgctttgtt ccacatttca tcgtcatcaa aatatttctc tgtatcttcc ggatcgcggt 2641741 aagacagacg gaatgtgtaa tcacttaaac cgaagtcttc ataaacatcc tggattaaac 2641801 ggactgtacg gataaactca tccttaattt gatccgggcg cacaaagatg tgtgcatcat 2641861 ttaacgtcat tccgcgtacc cgttgaagtc ctgacagcgc acctgacatt tcatagcggt 2641921 gcatcgttcc aagctctgca atacgaatcg gaagctcgcg gtaactgtga atgtcttgtt 2641981 tgtaaatcat catatggtgc ggacagttca tcggacgcaa tacaagtgtt tcattgtcca 2642041 tttccatcgg agggaacatg ccttcctgat aatgatccca gtgtcctgat gtttcataca 2642101 gctctttgct gcctagcaca ggtgtgtata cgtgctcata gccgaggctg atttctttat 2642161 cgacaatgta gcgctcgatg acgcggcgga ttgttgcgcc ttttggcagc caaagcggca 2642221 ggccttgtcc gactttttga gagttcgcga acagctttaa ttctttgcca agctttctgt 2642281 ggtcgcgttc tttcgcttct tctagcatac gaagatgctc ttcaagatca gcttttttga 2642341 agaaagctgt accatatacg cgctgaagca tttggttttt gctgtcaccg cgccagtatg 2642401 cgcctgcaag gcttaacagc ttaaattctt tgatttttcc ggttgaagga acatggacgc 2642461 cgcggcacag gtcaaagaat tcgccttgct catagatcga aacggtttct ccttcaggaa 2642521 tcgcatccaa tagttcaagc ttcaggtcgt cgccgatttc cgcaaaacgg gctttcgctt 2642581 cttcacggct gacttctttt cgaacgatcg gaaggttcgc attaacgatt tttttcattt 2642641 ctttctcgat tttcggcaga tcctccggtg taatcgcttc gtccatttct acatcgtagt 2642701 aaaaaccgtt ttcgataacc ggaccgacgc cgaatttaac atccttgtag atgcgtttaa 2642761 tcgcttgagc cagcaagtga gccgcactgt ggcgcataat ttgaagacct tcttctgagc 2642821 cttctgtaat gatttccact gtaccgtctt cattgatcgg cgttctcaaa tcgatttctt 2642881 ttccgttcag ttttccggct aatgactttt tctttaatcc cggactgatg gatgccgcga 2642941 tatcttctgt tgttgttcct ttcgcaaact ccttgactgc tccatcagga aatgtgattt 2643001 ttaccatatc tgacatcttt gtcactcctt tttttgcata taaaaacccc gccccctatg 2643061 aaagggacga ggttgaataa acggaatcgt ggttccaccc ttttttccgc aaagccaata 2643121 cacggcacct gcggctctaa gctctgtaac gggagttccc gtcagccatt actgttcctt 2643181 ttcaagaggt tcacagctga agttcaaagg cggtaaagcg aatggtcctt agctgggaag 2643241 cttgcagcca gggcttccct ctctttgagc cggtatcatt ccttcgtgtc cttatcaata 2643301 cgtgtgtctt tcttaatctc ctatgtatta taaattgttc aatccaaaaa atcaacacga 2643361 tcgcgtttcc ttttttttaa accgacagcc ttaaatagac aggctgccgg ccctcatcct 2643421 tccgagtgct tcaccggtat ttctgcatct gtaaaagcat gcagcgggag catttccact 2643481 ctctcttgaa atacgttttg aatggtcctt gccatcatgt gctcgggctg gtcggtataa 2643541 agcacgactt catcaggcgc aatggaaatc agcggcgcga gcaaatgaga atcaatatac 2643601 ataggatgat cccggacaaa tcttctgtct atgtatttca ttttttcccg ttccggcaca 2643661 tagcgcagct cccataatgt aaaggaacca tcatggacaa tatgcacttt tttgattcgc 2643721 ggctgtttgg cgtccacata gtctctgagt gtttgaataa agttttgata ttcctgttcc 2643781 atcttatatt catcaatcgc tgcttctgta atatctctca gctgcttata gtatgatcca 2643841 agtcggaagg tctgaaagga gcgaatgtaa aatactcctt cctctaaaca gatcgtttgg 2643901 agttcatcca aaattgattg tttccgtgaa agcttcagcg gctcaaacgg aagatcgtct 2643961 gcttcacctt caataatact gtgtgcgagc tgaaggattt gctgctgttc atcctggtcc 2644021 gtgaaacaat acgtttcctc aatcaatgac agcatatgct cgtcttcttt gcattccaaa 2644081 aaaaatttga ccagaatcgg ctccataaaa cgctgaatag gaaaagccgg attcgctttt 2644141 tcaatcccga tttttcgtat gccttcacgg acaatgatat tgttccgatc gtccgaatgc 2644201 tgaatgagat gtaaaaaagc ggctgcatca tggtcatctt caaagattat ttcaagcatg 2644261 tttgtccccc cttacggcat ctgttacaag tatatggggg atgtttttaa aatagacgta 2644321 aaggtcattg gcaaatctta atttgattct tggaacaagt tttgcatttt ctttctgaag 2644381 atgaacggca atgagataaa cacgatatac aaagcgagca ccataaagaa agcgggcaga 2644441 ttgccagcca aaaagctcgc acccagcaca ttaagcgcaa tcgtcccagg gatgattccc 2644501 acagccgttg cggcaaaata cggcagcgct ttgacattgg aaaggcctgc cgcatagctg 2644561 acgaaatcaa aattgatcgg caggattctc aaaagaaaga tatagaaaaa tccgttatcc 2644621 tccatttgct tctgtatggc ttcaagcctt tcgtaatgcc cgttcttttt cgccgaaaac 2644681 aaaccagccg caaaaaacga aacagctgaa gcgcacatcg aaccgaataa cgtataaagc 2644741 gtgccgagaa gcgggccaaa cgcaagtccg ccagctattg aaataacaga caccggaaat 2644801 aaaacaagtg gcctgacgat ggatatcccg ataaacatca gaggtgcaaa gactccgaac 2644861 gacaataccc ataccctgat ttctttcggc gatacattca aatacgtttt atttccccaa 2644921 tagagtaaac cagcacctgc aagcactgcc agccatttga cagccgtttt tcgtttcata 2644981 ccctcagttc cttccccttt gaaccacagc aattatggat gtcggcggtt ttctccgtca 2645041 aggcggatcg gagcagccaa atataatatc cgctccatta atcttgcagc ttttacttct 2645101 tctttttctc ccctctgcga atacgtaaaa tgatgcttca gctcgtcagg tgagaaatta 2645161 gaagaaaaga acgttggcag ctgctgggac attctgtgct gaagcaccgt tccgatgacc 2645221 tcatccctta cccagcttgt cattgattct gctccgatgt catcaagcat taatacgggt 2645281 gtggtcttta ccatattgag cttctcttcc aatgtctggt cttgcagcga attcttaagc 2645341 tctctcacaa attcaggcac ataaacaatc atggaggaat actctttttc cgccagctca 2645401 ttggcaattg cagcgagcat aaacgttttt cctaccccaa atttcccgta taaatataat 2645461 cctttccctt ttcccgtctc attatagctt ttcaggaagt ctgtaacatg ctgaaacatc 2645521 gcgagtctgc ttgggtcact gatatcaact tgctggaacg tcgctccaag aagatcctgc 2645581 tggatataca tgcttttcat aagagactgt tgtttcttct gctggtcgag cttccgtttg 2645641 actggacatt cgtaatactc gatatcaata gacctcccat tgacaacaag cttcggatgg 2645701 tagccctcca acaaattgtt gcagttttca tcttccgaac aataggagca attcttgctt 2645761 tgttcgatat attcataaag cttatttaag ctcttttcga tcattttttg gtcaatcact 2645821 tcttcgtttt ccttcaaaaa tgcttgaaca tcttgatctt tcatgacttt ttccttcatt 2645881 tgttcaagac gtttttggaa atccggcctg ccggttacgc cctgcaggga acggccgatt 2645941 ggttccatct attccttcac cccgcatctc tgtctttaat aggcagagta ttttttcagt 2646001 ttttgcattt cttccatcat ctttttcttc tgttcttcca aatcctgcgg atgcagcttc 2646061 tgctgtccgg attctgaatc ggacgctgtt tccttttctg tcatccaatc aggaagcttt 2646121 tcttcacgaa tcactttttg gtttcgtttc gaagactttg tttttccctc agcccattca 2646181 agatactggc ggttttcttc tattgcgagc ttcatcgctt ccctgaccgt tttcaccttt 2646241 ttgcgtgccc aatgcgaagc gattttttgg atatagtttt tcgacagctt catgtcggtt 2646301 ttcagcatga cataataaat taacacattt gtgacgcctg gctcgagctt ctgttcgaac 2646361 ataatttctt ctatgatctt cagatcagct tttgacggct ctgttccgtc agcaatgtcc 2646421 tgcagaagct tcttcgggga aatcgcctcc agcaatgcaa tcagcttccc atccagagaa 2646481 tcctcttctg ccggttgttc gccttcacgc agatgcaccg gctgtgtttt ttccaccaaa 2646541 tcgggcagct gtccgtttct ttcaatttga taccagtcgc tcgccgcttt tcttaatgcc 2646601 tccgtcgtaa tgacgtcacg ctcatcaatt gcgctcatca caacattttg catttgcaaa 2646661 gggtcaattc cgtacagata agaaagcttt ttgattgtgt cccgcacctg ctgggtcatc 2646721 gcttttctcg gtatcatcgt ctcagaaagt cccgctaaaa acaaatcaaa atcaaacaca 2646781 tcctccgtta tggtgtagga cggagactgt ccgacagaag tatactcgga cccctcggca 2646841 agccttaccg tttcctccat atcggatgtg agcttccatt cactcggctg cagcgattca 2646901 aacgcatgat taaacggacg cgtaatgtcc ttcgcatctt ctgaaatggc cgggtgcgta 2646961 aaaaattgtt ttaattgctg atatttcgtt tttccgaccc tattatacag aaaaacattc 2647021 agcattccgt cttcaaaaaa ttcatttggt ctgagcggcg gaaggagttc atatataaag 2647081 aggcgctcct gccgctcgga ttctttcata tatactttca gcaatccgat gccctcgagc 2647141 ttcccctgtt cctgatggat cgtttttaag ttggactgtg tcatccccat cagctgtcta 2647201 tgtgtggact ctccgcccca cagacggttt tgttcaagct ctccccacaa tgtcatataa 2647261 agagagaatg caacagggcc gattaagggc tggtacagtt gtgtaataat ttgtctgtca 2647321 atatcctgca gcatcgatct gcttttaacc acatacgggt ctacaggcag tacatctttc 2647381 caatagtcag ccatacattc tcaaaccttc cgaatttgtt tctacctttc attttacacc 2647441 gtttcttata tctatcaaat gccaattttg cacatgagaa aagagctaga agaatcctct 2647501 tagctctttt aacgctcttt ctttattaag tcttttaatt catcgataaa gacgtttata 2647561 tctttaaact gccgatagac ggacgcgaac cgcacatatg cgacttcgtc aatcttagcc 2647621 agccggtcca tgaccatttc tccgacgagc tcactcttca cctcggagca gccttgattg 2647681 cgaagttctt tttcaatatc aaagcacatg tcttcaagcg ttttgagtga aacaggcctt 2647741 ttttcacatg cttttatgag gccgcgcagc attttttctc tgctgaattc ctcacgcaca 2647801 ccttcttttt tcacaacgat gagcggggtt tcctccactt tctcaaaggt cgtaaaccgg 2647861 tagtggcagg attcgcactc gcgtcttcgg cgaatcgact ttccgtcatc cacaggccgt 2647921 gaatcaagga ctcgtgttcc gttatgctgg catgaaggac atttcaataa aatcagctcc 2647981 caactatatc gttccctgca atgtattttc ggcagcctcc gccttttaaa aatagatgtg 2648041 acagcatctg tcgggagagc cgttgttaaa tttgtttcta tagcattagg tggtttgtga 2648101 aaatctcctt cttattttac aaaaaaaatg aaaaaagaaa aagctgacac tctcgtttct 2648161 ttataaaaat aaaaggagca taagctaaaa agcgcataat ggctttctag cttcagctcc 2648221 ctttgtgttc gcaatttact ttatagtact ttcgcttgcg cctgtttaat ttgcacaggc 2648281 cccattcctc ttggtatttc aatgttttct cttgtatcag catgtaatgc ctctgcaatg 2648341 taatcagcag cgacattagg atctaagtct ccacaagtat aaacatcaat gctcgcatat 2648401 ccgtgctcag gaaaactgtg aatcgttaag tgtgattcag aaataatcac aactccgctt 2648461 acgccttgcg gtgcaaattt gtgaaatgca acctcgcgca cctcagcacc tgattttaga 2648521 gcagcattta caaacgtttt ttcaataaaa tccatgtcat tcagcttatc aaaatcgcat 2648581 ccccatagct cggagataac gtgacgcccc attgtttcca tagtcatgga ccccccttaa 2648641 caagaattaa aaagtgaaat tccaacaact gggtcggcca tttaccacgg gggaaagtta 2648701 gtccggagag gtcctaaccc tttaagtaat tccgaaacag tctcaagcaa gaagttcacg 2648761 aaaaatagta tactgtgttt aagtctaatt tgcaaggtgc gttttttcag aaatatgctg 2648821 ttaagggttt tttctttaaa atgtgtccat gaccttattt tatacagcag acggatgttt 2648881 cattcgtgcc gctacatggc ggattagatc aacaactctg caggagtagc cccattcgtt 2648941 gtcataccac gccagcacct ttactttcct gtcttccatt accattgttg taagcccgtc 2649001 aatgaccgct gaatgcggat tcgtattata atcagtcgaa acgagcggtt catctgagta 2649061 atcaagtaca ccgtacatcg acgttttggc agcgcgttta aatgcctcgt ttacttcttc 2649121 agccgtaaca tccgttttca gatcaacaac gagatcaacc aatgagacgt tcggaacagg 2649181 gacacgcaag gcgaggccgt gaagttttcc tttcagatgc ggcagcacaa gcgaaagcgc 2649241 ctttgccgct cctgttgttg ttggaatgat ggattcaccg caagcccgcg cccggcgcaa 2649301 atctttgtgc gggttatcaa tatttttttg gtcattcgta tacgcatgaa ctgtagtcat 2649361 cagaccgctc tcaatgccaa actcttcatc cagcactttt acaacaggcg caaggcaatt 2649421 tgtcgtgcat gacgcatttg aaataatgac atggcgctca gcgtcgaatt ggtcctcatt 2649481 tacgcccatc acaatggtaa cgtcttcatt ttttcccgga gcggtcaaaa tcactttttt 2649541 tgcacctgct tctatatggc ccatcgcttt atctttagca ttaaacttcc ctgttgcttc 2649601 gacgactatg tcaatatcat attcccgcca aggcagctgt tttggatcac ggctgtttaa 2649661 caaaagcact ttctttccat ttacgatcag gctatcttca ccagccacaa cctctttgtc 2649721 gtatctgccg tgaattgtgt catactttat taaatgagcc agcgtttctg cggaatagct 2649781 ggcgttaatg gccactactt gaatttgatc gtctaacatc gcttttctaa aaaccattct 2649841 tccgattctt ccaaacccgt tgatcgctac ttttaccttc atgttggaca ccccttatca 2649901 attatgccat cctaatttgt tactatctaa aattagtata acacattaaa acaaattcgc 2649961 cagtacatat tgataaaaat caacgattat aacgctaatt tatgatgcat cttatgtttt 2650021 cttgcacaga atatcaggcg taagaaccaa aaagcagcca gcgctccgca ctgactgccc 2650081 tcatgcttta tgattcctgt tttaacttat cattgagcac actttcttct agcacagaaa 2650141 atgtatcccc gtacactctg ttaatatgat tcgctcccca agcacacagc atatctaaaa 2650201 tcccttctaa gctgcggccg tattcgctga gctcgtattc cactttggga ggaacttgat 2650261 tatatacgat tcggttaatg acaccgtccg cttccagctc gcgcagctgc tgagtcagca 2650321 ttttttgcgt gatattgggc attaggcgtt ttaattcact tgtgcgtttt tttccgtgcg 2650381 tcagatggca taaaatgacg catttccatt tcccaccgat cacttcaaga gtcgcttcaa 2650441 cagaaatgtt atattttttc ttctccatac aatccattct cctcacaggc accaaaaagt 2650501 gactatagca cttcaaagta cgtactttta tttcttaacg atatgtttca taatcacatt 2650561 tgccggctga tttgaatctg ctctttttta tttatatagc ttactcggca gaatttcaat 2650621 catacaacac atcttacaaa ggaggaacat catgacttca gccaataaaa gcaatattcc 2650681 tgcactactg gctttggccg taagtgcatt cgcaataggg acaactgaat ttatcagtgt 2650741 cggccttttg ccgctcattg ctgatgacct ggatattccc gtcacgacag caggattgac 2650801 cgtttccctt tatgcgctcg gcgttacatt tggggcacct atattaactt cattgacctc 2650861 aagcatgtca cgtaagacac tattgctttg gatcatgttt atttttattg ccggtaatac 2650921 gatggcagca accgcttcaa gcatcgggat tttactagca gcacgtgtga tatcggcatt 2650981 ttcgcacggt gtgtttatgt cgatcggttc gacaatcgca gcggatattg tcccggagga 2651041 taaaagggct agcgcgattt caattatgtt tactggcctc actgtggcaa ctgtaaccgg 2651101 agttcctttt gggacattta tcggccagca gttcggctgg cgtttcgcct ttatggtcat 2651161 tatcgccgtc ggaatcattg ctttcattac aaatggcatt cttgtaccgt ccaaattacg 2651221 aaaagggacg aaaacaacga tgcgggatca attgaagctt gtgacaaaca gccggttatt 2651281 gcttttattt gtcattacag cgcttggata cggaggaaca ttcgttgtgt tcacgtatct 2651341 gtctcccctg cttcaggaag taacaggctt caaagccggg actgttgcag tgattctgct 2651401 cggatacgga atagctattg ctatcggcaa tatgattggc ggaaagctgt caaaccgaaa 2651461 tccgattgcc gctttattct atatgtttat cgtacaggca atcgttctat tcgtactgac 2651521 atttacagcc ccgtatcaag cagcagggct cattaccatt ctctgtatgg gattgctggc 2651581 ctttatgaac gtgcccggcc ttcaggtgta tgtcgtcatg ctggctgagc gttttgtccc 2651641 gagtgcagtt gacgtcgcat ccgcgatgaa tatcgctgcc tttaatgcag ggatcgcgct 2651701 tgggtcatac cttggcggtg tgatcaccga ttcaatcgga ttgattcata ccgcttggat 2651761 aggcggatta atggtggtcg gtgcagtcat tttaacaggc tggagccgct tgatggaaaa 2651821 acgagatcgg caggaagcct gacaatttta aaggaggaaa taaacatgac aacacattta 2651881 caagcaaaag caacacttca taatggggta gaaatgcctt ggttcggcct cggcgtgttc 2651941 caagtggaag aaggatctga actggtaaac gcagttaaaa ctgccattgt tcacgggtac 2652001 cgcagtattg atactgcagc aatctatgga aatgaagctg gagtcggaga agggattcgg 2652061 gaaggcattg aagaagcagg catttcaaga gaggatctgt ttatcacatc gaaagtatgg 2652121 aatgcggatt taggctacga agaaacactc gccgcgtttg aaacaagtct gtccaaactc 2652181 ggtctggatt atttggatct atacctcatc cactggcctg tagaaggaaa gtataaagaa 2652241 gcttggagag cgcttgaaac gctgtataaa gaaggccgta tcaaagcgat tggcgtaagc 2652301 aacttccaaa ttcaccatct tgaagatctg atgacggcag ctgaaattaa gcctatgatt 2652361 aaccaagtgg aatttcaccc gcgcctcaca caaaaagagt tgataagata ctgccaaaat 2652421 cagggcatcc agatggaggc ttggtcacct ttaatgcagg gacagctgct ggatcaccct 2652481 gtattggctg acatcgctca aacatataat aaatctgtcg cacaaattat tttgcgctgg 2652541 gatctgcagc atggcattat aacgattcct aaatcaacga aggaacaccg cattaaagaa 2652601 aatgcaagcg tatttgactt tgaattaacg caggatgaca tgaaccgaat cgatgcactg 2652661 aatgaaaact tgcgcgtcgg tcctgatccg gacaactttg atttttaatg gccaaaaaac 2652721 accgttcaat atgaacggtg ttttttgtat tatgcccagc tgttcatgat ttcatcaagc 2652781 tgccttttgg tctcttcaag cgtgccgctg ttatcaatga cttgatctgc tcttgctgtt 2652841 ttttcctcta agggcatttg agagcggata cggctgactg cttcttcttc tgtcagctga 2652901 ttgcgcttca tcagacgttc cagttgaagc tcttttgtca cactgaccac aataatttta 2652961 tcaaccaatg attccaattt gctttcgaac aatagcggga tatccaatac aacaaatgcc 2653021 tcccgatttg caacggcttc atcacggcga ttgagcattt cctgcctgac tgcgggatga 2653081 acaattgcat ttaaagcgag acgtttttgt tcatttgtaa ataccagcgc tccaagcttt 2653141 tttctatcta tatcgccatt tgagagcagt atgtcttcac cgaattcgtc aatgatttgc 2653201 cggtaggccg gcatcccttt ttctaccgct tgttttgcaa tgatatctgc atctataact 2653261 gttattcctt tttcaatcag catattggct accgtgcttt tgccgctagc tattcctccc 2653321 gttaaaccaa tgactaaggt caagagatcc actccttttt acaatttcca gagcccaatc 2653381 gtgattaata gaagccccgg caaaaacgcc attttatcga tccatttcca cttagacaga 2653441 aaatggccgg cattgattcc aattgataca aacagcgagc tcatgattgc cacggcgatg 2653501 ctcatcacaa tcggcgaaaa accgagaatg gctgcgccta tacctgctcc aaaggcatca 2653561 atcgataagg caaatcccaa taagaccgcc tcaattccgt tgatcacacc cgatttgtcg 2653621 atatccgcac tcatgggttt tctcaaaata tgaatcacaa ttcctaatga ccgaacctct 2653681 agattaagca gtgttttttc atgcaatagg tattctttat cttttgccgg tttgaaaaat 2653741 tgatacagaa cccacgcacc gattccaacc aatatcaaac cgccaagctt ctccgtcaca 2653801 tatacaggaa aaaacttcgt gagaaagctt ccgatcagca tggatataaa catgacagca 2653861 ccggaacagc aggcgataac caaaatcgct ttaaacggta ttttcatttt tctcaatccg 2653921 tacgtaaatc cgactgaaaa actgtccaag ctgacagcca acgccagcag cagtatagaa 2653981 accatttgca tatccgtttc ttcctttctg ttggtgctct tgtatcagat gtgaaatgcc 2654041 cgggattcat cacaatcata tatatgggaa agtgaaaaat ccgtgtttcg aaaatggcat 2654101 ccttaatcca gagttactga tatatgcacc gacagcttgg acaatgaagc attatgctac 2654161 ttttttgtct ggcactttgc gcaaaaatgc gtgcctcttc ctccaacgac aattttcgaa 2654221 atcatcgttc cgcaattttt gcatggctcg tctttttttc cgtacacaaa atgctgcagc 2654281 tggaacattc cgatttcccc ttgggagttg atatatgaac ggactgtgct tccgcccgca 2654341 tcaatcgcct cctgcagagt gtttttgatt tcagcgtgaa gggttttgat tgttttatct 2654401 gataattgat ttgcttttgt ctcgggatgg acacccgctc tgaaaagagc ctcatccaca 2654461 taaatgttcc cgagtccaac taccgttttt tgatccagta gggcagtttt gacagcgcgg 2654521 tttgttttcg caagccggtc ttttaaatac gcacttgtaa attcttctgc atccggctcc 2654581 ggccctaact gagaaagcgg gagctcgccc gcttcttctc ccggtttaaa taagtgcatg 2654641 gttccaaatt tccgcacatc cctgtaccgg agctgggttc catccgtcat cgtgaatatg 2654701 acatgcacgt gtttatcgtc aggctcctcg gcttgatgaa gaccgtattt tccttccatt 2654761 cgaaggtgag aaaccataac ataatgatct aaatgaaaca gtaaaaactt tccccgtctt 2654821 ccgatggact gtatcgtttc tcctgctagt tttcgcgcaa attcctccgg ttcggcaggc 2654881 cgtttgatga tattcggcca tctgatctct accgatttga ttgtttttcc ctttacaagc 2654941 ccggtcagag tgcgccggac cgtctcaacc tctggtaatt ccggcacatc catcacttcc 2655001 tatctctgtt tatttcgcat cgtaccaaga tgggcctgat gcaaagtcca cctttaacgg 2655061 cacatctaat gcaagcgcat gctccatcac ttcaggaaca agcttttcaa gaatttcaat 2655121 ttcttccttt ggcgcctcaa aaatcaattc atcgtgtact tgaagcagaa gccttgcttt 2655181 caactgtttt tctttcagct tggcagccat gtcaatcatg gcttttttga taatatcagc 2655241 ggcgcttcct tgaatcggcg tattcatggc cgtccgctcc gcaaaacttc ggatattaaa 2655301 gttccggctc gtcagctcag ggatgtagcg gcggcgatgc ataagcgttg ttacgtatcc 2655361 tttttgtttc gcttcctgta ctgaatcttc catgtacgct tttacgcctt ggaagctttc 2655421 cagatagcgg tcgataaatg ctcccgcttc cttccgggta atgccgaggt tctgtgacag 2655481 accgtaatcg ctgatcccgt aaacaatgcc aaagttgacc gctttcgcct ggcgtctcat 2655541 cgcagatgtc acttcatcct tagcgacatg gaacacatcc attgccgttt tcgtgtgaat 2655601 atccatatca ttagtaaaag cttcgatcag attttcatcc tttgaaatat gggcaagcac 2655661 ccgcagctcg atttgtgaat aatcggctgc aaaaatgagc cagtcttttt cagacggcac 2655721 aaaagcttgg cgaattttcc gcccttcctc aagcctgatc ggaatgtttt gcaggttcgg 2655781 atcagtcgag ctgagacggc cagtttgcgt taaggcctgg ttaaatcgcg tgtgcacttt 2655841 atgcgaatcc ggtctcgtca cctttaaaag cccttcgata tatgttgatt gaagcttgcc 2655901 aatttgtctg tactgtaaaa tatagtcgac aatatcatgc ttgtcagcca gcttttcaag 2655961 cacatcggca gacgtagaat agcctgtttt cgttttcttt acgacaggaa ggccgatctt 2656021 ttcaaataag atgacgccta gctgtttcgg agaattgatg ttaaacggct ctcccgcaat 2656081 ctcatggatt ttttcttcat attccttcag cttcgcaccc agttcttcac ccatccgttt 2656141 taaacggtca acatcgacct tgacgccagt tgattccatt tcgccaagaa taagcgcaag 2656201 aggcatttcc agctcttcaa acagttcaag ctggtcgttg ttttccagct cttgaacgag 2656261 cttttcccga aggctttgaa tcgctaacgc ttttcggcca aggtgctcag acagtacgtc 2656321 ttctgacggc actgcccgtt ttgctccttt tccataaact gattcatcac ttgaaacgat 2656381 atgcaggccg taatccttag ccacactcgc aacgtcgtca tatgaattgc ccgggttgat 2656441 gatataagcc gcaaggagcg tatcaaactc ggctcctttc agctcaatgc cctgccagcg 2656501 caaagcgaca acggcccgct tgctgtcgaa gacccatttc ttctgctcgt cattttccac 2656561 ccattcttta aacacctcag actcaacggc aatgtctttc ggaatgaaat aagctcccgt 2656621 ttcatttacg atcgaaaatc cgaggatcgg ctcttcatga taattatcgc caatctgttc 2656681 aacgacaaat gcggatggag aaaccaatat atcgcttgtc acgtctgtga ctgttttgac 2656741 attaatgtct tccaacgatt gatcctgttc tgcttctgca ctgtcttctc caagccgttc 2656801 aagaagcgtg ttgaagccaa gatctttaaa gatggcaatg acctgttcac gattaaagcc 2656861 ttgatattcc aggccggaaa cagatacctc aatcggagca tccgtcataa ttgtcgcaag 2656921 ctccttgctc atcaatgcct gatccttaaa ctcctcaagc ttttccttca atttctttcc 2656981 gctcacctcg tcaatggact ccagcagctt ttcaacggaa tcaaattgtt ttaaaagctt 2657041 aatcgcagtc ttttctccga cgccgggcac acccggaata ttatctgagg aatcgcccat 2657101 cagacccttc atgtcaatga tttgttcagg cgtaagccca tatttctctt tgacatgctc 2657161 cggtgtgtaa aattcaacat cggtaattcc ctttctcgta atggcaactg tcgttttgtc 2657221 cgttgccagc tgggttaaat ccttatctcc tgagaaaacc ttaacttcaa atccgtcttt 2657281 ttcagccgat ttggccagtg tgccgataat atcatccgct tcatattgtt ccagttcata 2657341 gcggctgatc tggtaggcat ccagcagctc gcggataaac ggcatttgtt cggaaagctc 2657401 aggcggggtt ttctgtctgc cgcctttata ttctttaaat gtgccgtgac gaaatgttgt 2657461 tttcccggca tcaaacgcaa ccagcatgtg cgtcggtttt tcatcctcaa gcattttcat 2657521 caaaatcatc gcaaagccgt atacagcatt cgtatgaaca cctttatcat tgcttaacag 2657581 cggcaatgca aaaaacgccc ggtaagccag actgtttccg tctacaagca ctaatttttt 2657641 tcgttccgtc attcaatttc ctcctaagaa gcctcaggct tccattcatc tcttacatag 2657701 tcattagctc ctcttatttt aacaaagttc aatttgaaag gaaaatacgt gaactataag 2657761 agaagacaca aaaaaggacg ggaacacaaa taggttcccg ccgtcaaaat tggctccttg 2657821 gatgaagggg ttctactaca tcctaccagc ataggtttaa cagtgcatga agatattgtt 2657881 aaacctttgt aaacattagg cggacttttc agcggcccgt ttcagcgtca cggtaaagac 2657941 agttccccgt ccaagctcgc ttgtgacatc aattttccct tcatgagcct ctattaaatg 2658001 cttgacaatc gctaggccca gcccggttcc gcccgaattt ctgcttctgt ctttatctac 2658061 acggtaaaag cgttcaaaga tgcgcggaat ttcttctttc tgaattccga ttccagaatc 2658121 ggcaacctca atctgaatgt ctttttctct gggctttaca ttgatagcca cggagccccc 2658181 ctcaggcgtg taggttaatg cattgtttac gagattaaga aatacctgtt tcagcctgta 2658241 cgggtcacca gatacatatt gagggtcttt cgggacattc aggtgcaagg agatgccttt 2658301 ctcatccgcc ttatgcttca gaagcgtttc aatctcacca agcattttgg ccggctcaaa 2658361 cgtttcgata ctgagcgtga aattttgctg ctcgattttt gagagatcga gcaaatcctg 2658421 aaccaaagac tgaagccttt cgctttcctt aagaataata gagagaaatt cagaaagcgc 2658481 ctctttgtct tccatcgccc cgtccaataa cgtctccgta aaccctttta tggacgtaat 2658541 cggtgttttc agctcatgag aaacattggc cacaaaatcc ttcctcatct gctctaattt 2658601 cttcgtttcc gtcatgtcat ggaaaacgag cacaattcct ttccattcat cgtccggccc 2658661 cataatcgga acgccgtcca cttcaaaata acgccgttct attttgatcg gcagtcttaa 2658721 cagcttgcat ttctttgtct ccgtcataaa aatgtcttcg acaagctgga tcacttcttc 2658781 atgttcaaat gcatcgtgat aaagacggcg cagcatatga ttcggattga tatgaaactg 2658841 cttggcgtaa gacctgttta cgagattaat aaagcctctt ccgtcgatca taatcagccc 2658901 ggagccaatg ttttcaatga ctgtcagcag ccgatcccgc tgcatttcct gcgttcgcgt 2658961 catttccatc agatcaatgg caaggctgtt catcgcatgt cctagcttat cagaacgcct 2659021 aatatagccg ccgtacgtcc gtgcatcgta gttgccctta gagagttctg tggctacatt 2659081 tgtcgctgac tcaattgacc ttttataacg tgaggtcatg ctggaataaa aataaacaat 2659141 gacgataaat gcggtacaaa gactggccgt cagcatcccc cacaattcgc cttttaagcc 2659201 gtcgcttttt tcagaggcgg aaagcagcac atatcctgtt ttttcacctt cgcttctaag 2659261 tgaaagtccg taataaagct tgttatctgt tgttgacaga ataccctcat ggccagaaac 2659321 aagcgcctgc accttttggg aatcagccga tctaccgttt gacccataca gcaccttacc 2659381 gtctgtatcg ataacggatg cgctcacatc aagcgcgccg cctgcatctt taatgatttt 2659441 ctcatttgct tgattattca gattgccggc atcaagaagc gaagccaagt attttgcttc 2659501 tttttcaatg tgttcctctg ctttcctttg atcagatgtt tcaaaaagct gctgtaaaaa 2659561 cagcccgagg acacaaaaca ccagaatcat acagacaacg aatacagaaa aaaggcgcac 2659621 acggtattta ttcattcatt tttggctcct ccagtttata ccccaatccc ctaatcgttt 2659681 taatgtagat cggttttttg gtattgtttt caattttgtc gcgaagatgg ctgatgtgca 2659741 catcaacaat tctcgtatct ccggcaaaat cataattcca gactgcgctc agcagcaggt 2659801 ctcttgtcag aactctgcct ttatgtctgc ctaaatagag cagcagttcg aattctttcg 2659861 gtgtcagttc aagctgactt tctttaaagt acgcttcata atgatcaggc aggattttca 2659921 gatcgccgat tacgatctgg ccttccattt catcgttctt catctcacta gagggcgcag 2659981 ctatttccga acgccttaaa atcgctttga ctctcgcatt tacttccctt ggactgaacg 2660041 gcttggtcat ataatcatca gcaccgagct ccagccctaa tactttgtcg aattcctcat 2660101 ccttcgctgt cagcattaaa atgggaaaca tcagtttttg ctgtctcagc tgcttgcata 2660161 cttcgattcc gtccaatttt ggaagcatca catcaagcac aatcaaatca ggtttctctg 2660221 tttccgcttt tttgagtgct tcttccccat ccgaggcggt aatgacatca tagcctgacc 2660281 gttccaaatt gtactgtaaa agagtaacaa tagattcttc atcatccaca actaaaattt 2660341 tcttgttcat gctgtgcctc cagtattata attccccgac atcctatttc tctattttat 2660401 gtcatcttaa catgtttcat gattttattt tagcgaaagc aggacattcc gacaattcgc 2660461 cttttacatc atttttaaaa gaaataaaga cgtttatgat agcgctttca tttatagtaa 2660521 aaagagaaag gctgtattaa gcaagccttt ctctcttttt attaggataa tactttcatg 2660581 acatttttga cagattcaac tgatttattc agctgcgctc tttcatagtc tgtcagttca 2660641 agttcaatga tttgctcaag accgttgccg cctacaattg taggaacacc aaggtagatg 2660701 ccttcatagc cgtattcccc ttcaagataa gcaattgtag gaaggacgcg gcgctgatct 2660761 ttcaagatcg cttcgaccat ttctgtcaga gaagccgcag gcgcataata cgcgcttccg 2660821 tttccaagaa gattcacgat ttcgcctccg ccttttctag tgcgctccac aattgcgtca 2660881 atccgttctt tcggaataag agtttcaagc gggataccgc cagcataaga ataacgcaca 2660941 agcggaacca tatcgtcacc gtgtccgccg agtacgaaac cagtcacatc tttcactgac 2661001 aggtttaatt cctctgccac aaatgttctg aatcttgccg tatcaagcac acctgactgg 2661061 ccgattacac gctctttagg gaagcctgat tctttgtaca ccgcgtatgt cattgcatca 2661121 acaggatttg tcagcaccac aataatagag tcaggagaat atttcacgat ttcctgcgta 2661181 acgcttctca taatcttttc gtttgtagag accagatcat ctctgctcat accaggtttt 2661241 cttgcgatac cggctgtaat gacaacaatg tcagagccgg ctgtatcctc gtaattggat 2661301 gttcccgtaa tttttgcgtc aaagccttga accgggcttg cttcaagcat atcaagcgct 2661361 tttccctttg tcgggttctc caattgcgga atgtcaacaa gaacaacgtc tgccagctct 2661421 ttttgagcga ttaaaaatgc agttgtagct ccggtaaaac ctgctccgat aacagaaact 2661481 tttttacgag tatttcccat gtctctcttc tcctttatgg ctagttttag gctttttcct 2661541 tgcttagtcc atgtttttga tcagttcttc tccgaactct gaacatttca cttcagtcgc 2661601 cccgtccatt aatctggcaa aatcgtaagt tacgacttta gaagcgattg ttttttccat 2661661 agatttgata accaaatcag ccgcttcgtt ccatcctaaa tgctcaagaa gcagaacgcc 2661721 tgaaagaata actgaagatg ggtttacttt atcaaggcct gcatatttag gagccgttcc 2661781 gtgcgtcgcc tcgaaaatcg catgtcctgt ttcgtagttg atgttcgctc caggagcaat 2661841 gccgattccg ccgacttgcg cagcaagagc atcagaaatg taatctccgt tcaagttcat 2661901 tgtcgcaacg acatcaaact cgtttggacg cgttaagatc tgctgaagga aaatgtcagc 2661961 aatgctgtct ttgataatga tttttcctgc tgcttccgct tcgctttgcg ctttgttggc 2662021 agcgtctttt ccttgttctt cagcaatgcg gtcatattga gcccatgtga agactttatc 2662081 tccgtattct ttttcagcaa gttcatagcc ccagtttttg aaggcgcctt ctgtgaactt 2662141 catgatgttt cctttgtgaa caagtgttac agatttgcgg ccatgctcga tcgcataatc 2662201 aatggcagct ctgaccaagc ggcttgttcc ttcttctgaa acaggcttaa tgccgatacc 2662261 tgatgtctca gggaaacgga ttttattgac gtttaactca ttttgaagga agctgataag 2662321 cttttgcact tcttcagagc cttttgcata ctcgatgcct gcgtaaatat cttctgtatt 2662381 ttcacggaag atgaccatat cagtatcttc agggcgtttt accggtgacg gcactccagt 2662441 aaagtatctt acaggtctta agcagacgaa taggtcaagc tcttgtctga gcgctacgtt 2662501 caaagaacgg ataccgccgc cgacaggtgt cgttaacggg cctttaatcg cgatgaaata 2662561 ttcgcggatc acatctaatg tttcagcagg gagccactca cctgttttat tataagcctt 2662621 ttctccggcg taaacttctt tccatgtaat tttcttttcg cctttgtatg ctttttctac 2662681 tgctgcttcc aaaaccttcg aagccgcgtt ccaaatatca ggaccggttc cgtctccttc 2662741 gataaatggg ataatcgggt tgtttggtac gtttaatact ccgttagaga ctgtaatttt 2662801 ttcaccttgt gccacaataa aaacctccca gtatgtaatt catatttaga aaacatttta 2662861 tttttcttat atagaaaata aaatgatttt tcctaacatt caatttaaag tgtaacccaa 2662921 ttttgatgtc tgaacaagag gctaacctca ttgacgcaag ccagcctcca atggttcttt 2662981 aggctctttc ttcaatcgga acgaattttt gtttgtcagg gcctgtgtaa tctgcccgcg 2663041 ggcggatcag acggttgttg tcatactgct caagaatatg agcgagccag ccggacattc 2663101 tgcttacagc aaaaatcggt gtaaacaaat catggtcaat accgaggctg tgatatacag 2663161 aagccgaata gaaatcaacg ttaggcggaa gctttttctc tgatgtgacg atgtcttcta 2663221 tacgaatcga catctcatac catttgcttt cgcctgtcag gttggtcagg cgcttgctca 2663281 tttctttcag atgcttcgcg cgcggatcac catgcttata cacacggtgg ccgaatccca 2663341 tgattttttc tttcttttca agtttagcgc ggatgtacgg ctcagcgttt tccacttcac 2663401 cgatttctgt cagcattttc ataacgcctt cattcgctcc gccgtgaaga ggccctttca 2663461 gcgcgccgat tgctgcagta atgcctgaat agatgtcaga aagtgttgcg acgcagaccc 2663521 tcgctgtgaa cgttgacgcg ttcagctcat ggtcagcatg taaaatcaat gctttgttga 2663581 aggcttcaac ttcaattggt gaaggctctt caccgtttaa tgtgtaaaga aaattctccg 2663641 caataccgta atcttctctc ggttcaacag gctcaagacc cttgcgaatt ctggaaaacg 2663701 ctgcaaccag gccaggcacc tttgcctgaa ggcggatcgc ctttctgtag ttggcttccg 2663761 ggttcatggt atcagcctcg ctgtcaagca ggcctagtaa tgaaattgct gtccgaagag 2663821 cagccatggg atgaacattt tcgagggaat aagatttgaa gtgctcaata atttcttgcg 2663881 gaacggcagc ttcctttgca agctgctgct ttaactcttc aagctctttt ttgtttggca 2663941 gccttagatg ccaaagcaag tagatgattt cttcaaaact tgcattctct gtcaaatcat 2664001 cgatatcata ccccacatat gtaagggtat catcaataat agaactaaca gatgatgttg 2664061 ttgctacaac cccttcaaga ccgcgtgtcg ctgtcatata taacatctcc ttttcaataa 2664121 atttcccctt taagagtgtt gtaaaaacat gaggcttact taaaaagcac gatgcaagta 2664181 tttctctccc ccaaaaagaa aatgcttaca ttttactggc tgctggaact aaaacccttt 2664241 gcttttgaaa gaacataaca aatttttata agcttattta agtttaagcc tattctcatt 2664301 ataaacaata atcagacatt tgttaaatgt ttacctataa tttttttttt ccattctgtg 2664361 atttccccga aaaaacgcct ttatttgcgg gtttttgcat aaaaaaaagc ggctttaagg 2664421 ccgctttttt ttatgaagtg aacagtttta cgatctgcat ggctaaataa gcaatccccg 2664481 ctccgatcag cggccccacc gcaactcctc caaaaagcgc gactgcaaga atggtcccga 2664541 tcacgagagc agttgtaata tgcggatcat tttcaagcag ggtcaggccg ttttttgcaa 2664601 tcagcgccac tgcgatcccc gctccaaggg cgatccatgc gtaggaagac cgcattgctt 2664661 ctccaagctg cttaaatccg atttctcccg tggcaatcgg gacaagaacg gcgatggtaa 2664721 taatggtcac accccagtta atgccttttg actggatggt cggaaataat ttctgatcaa 2664781 gcccaacgat tttgatgatc aaaaggacgg atacagcaaa gagcaatgat tggttttttg 2664841 cgataagtgc gatagccaag agtaaaatta aaaataaatt cgcttgtgta aacacatgcc 2664901 atccctcctt taagatgaat gtattcatat tcagccgcag cgtgaataca tataaaaaat 2664961 aggacatgct gacgagagga ggaccgtttt tgtgaatcaa tcttatatca ctattttttt 2665021 cagaaccctc tttgtcatat caatgaccgc agggtcgata gctgcggcct attattcgtt 2665081 tccgttaact tatccgttcc tgatcgccct tattctatct tcagtgattc atcctgttgt 2665141 cgattatttg gacaaagtga caggattccc ccgaacgata aatgttctgg gcgttcttgc 2665201 tttttttctg ctcgcagcct tcggcgtgct caccattctg gtagccgaaa tcgtaacggg 2665261 aacagcctat ctagcaaaaa cgctgcctcc gcatatcagc acgtttattt catattgcga 2665321 aaaattgttt accactcata ttcagccgct ctataacgag ttaactcttt tgtttcaaga 2665381 attggaaacg aaccagcagg cttccatcgt cactcatatc cagacactcg gtgattctgc 2665441 cgctaaaaat gccgggctcc tgctgtccca cattctagag atgatcccga gatttttcgc 2665501 tcttcttccc aatacggcgg cggttctgat tttttctctt ctggcaacct tttttatgac 2665561 aaaggattgg cataagctga aagccatgct tgttttaatt ctgccggatc gtgtgacagc 2665621 taacagcaaa gcaatcagca gcgaattaaa aaaagcaatg actggtttta tcaaagcaca 2665681 agccgtcctc gttttcatca cgatggtgat tgtatttatc ggcctttctc tcttaaaggt 2665741 tgaacacgcc gcaacaattg cttttttaat cgggcttgta gatcttctcc cttacttagg 2665801 tgccggctcc gtatttgtgc cctggatttt gtatttatcg attacgggcc agctgcccca 2665861 agcaatcgga attggtatcc tgtacctcgt cgttcttatt cagcggcagc tgacagagcc 2665921 caagatacta agtaaatcta tcgggatcga tccgctggca acactcatcg ccctgtttgc 2665981 cggctttaaa ttattcgggt ttttaggact gattgcggga ccggctgtac tcgtcatcat 2666041 ccaagctttc atcacaacag gcgcattaaa agaaatatgg tcctatatca ccgttcagca 2666101 aaaataaaac ggcagccgtt ttttcatggc tgccgttttt tatttgatga tgatccgctt 2666161 attcttcgac attcctctca gccatttgaa cagaatcggc ttacaccagc cgcgggtaaa 2666221 cgggataaga agacaggcgc cggccaaatc tgataaaaag cccggaagca tcagcaatag 2666281 accgccaatg aaaatgcaca gaccgtcagc aatcgcttct cccggcattt tgccatattg 2666341 aagatcacgc tgaaccttat aatacacttc ggttccttgt ttttttgcag ctgctgcgcc 2666401 gataatgcca gtcagaatca tgaatagaac tgtcggcaaa ataccaatca gatttcctaa 2666461 aaataggaat ataccgattt ctattgccgg aaacacaata aaaagcaaaa acaaaaatct 2666521 catatccaag ccccccacac gtgtaacacg ttctgttcaa caaaaggcat gataaagaga 2666581 aaaggaaggg attccccttc cattttcacc tgtaattaaa gaacgctcgc acggccttga 2666641 tagactgcgc ctctggaagc gtcaactgta atatcctggc catctgtcaa aatagatgtc 2666701 gcattttcca gacccacgat aaccgggatg ccaaggctta atccgactac cgcagcatgg 2666761 ctagtcaaac cgccttcttc tgtaataaga gcagacgctt tttcaaggga tgcaatcata 2666821 tcacggtcag tgcttttggt aacaagtacc gcaccgtcag tcattttttg ctcagcttct 2666881 tttgcatttt gtgcaacgac aaccggaccg taagctgatt tgcgtccaat gccttggcct 2666941 ttagcgatga tatcgccgac agtatgaacc ttcattaagt tcgtagtgcc ggactcaccg 2667001 acagtgccag ctgtaataac gataagatcg ccgtgtttta caattccgct gttcaatgat 2667061 ttttggacag catcctcaag catctcatct gttgagctcg cattttggcc gctttccgcg 2667121 aatacgccag atacgagggc aagctttctg gaaatagagt catttacagt aaccgcaaca 2667181 atcggagcct gcggacggta ttttgcaatc atacgtgctg tatggccgct ttctgtcggc 2667241 gttacgatcg cagcagcatt caggttaatc gccgtatgtg cgacagattg tccaattgcg 2667301 tctgtaattg tcatgcccac ttggtctctg cgttttgaga gaatttcttt ataatttaat 2667361 gcttcttcag aacgggacgc gatgttatgc attgtttgaa ctgcttcaac cgggtaactt 2667421 ccggcagcag tttcaccaga aagcatgatc gcatctgttc cgtcgaagat cgcgtttgca 2667481 acgtcacttg cttccgcacg agtcggacgc gggttgcgct gcatgctgtc aagcatttgt 2667541 gtcgctgtaa taacaggttt gcccagcgcg ttgcattttt tgatcagttc tttttgcaca 2667601 agcggcactt cttcagctgg aatttccaca cctaagtctc cgcgtgcaac cattaagccg 2667661 tcagacactt cgagaatcgc atcgatgttg tcaacgccct cttggttttc gattttaggg 2667721 atgatttgaa tatcctgagc gttgtgctct tcaagaagct cacggatttc gagcacatcc 2667781 gtagaacgtc gaatgaaaga tggtgcgatg aagtctactc cttgctcaat accgaaaacg 2667841 atgtctcgcg catccttttc agtaatcccc ggaagattga cacttacgcc cggtacgtta 2667901 acaccttttt tatttttgag tgttccgttg tttaatactt ttgttttgat ttcgcgttta 2667961 gcggcatcta catcaagtac ctcaagaccg ataaggccgt catctaacag aatcgttgaa 2668021 ccttgttcaa cgtcatggac taaaccttca tatgtcactg aaattttatc tgttgttcct 2668081 acaacctcgt ccattgaaat aatgagctct ttgcctgttt caagctcaat accgccgttt 2668141 tccattgtat gtgtgcggat ttcaggacct tttgtatcaa gcagaattcc aacgttcttg 2668201 ccaagttttt tacttgcttc gcggatattt ttaattcttg caccgtgctc ctcaaaatct 2668261 ccgtgagaaa agtttaatcg agccacgttc attcctgact ccattaattt cgtaagcatt 2668321 tcaatacttt cacttgccgg accgatggta caaacaattt tagtttttct catttggttc 2668381 acttccttct gaaatcttca gccttcagct gtacattaga tagacagttc ttttgaaagc 2668441 tgatacatgt tttgctcaac tgtgtgtttt gtctcaagta tttctataat atcatggtct 2668501 acaagcttat tgttttgtat acctacacag cgtccgcctt ttccttcaag cagcagttca 2668561 actgcatatg cgccgagacg gcttgccaac acacggtcag cagcactcgg agaacctccg 2668621 cgctggatat ggcccaatac agatacccta gtttcaagat ttgtttcttc ttcaatgcgt 2668681 ttcccgaatt caacaccgct gcctacacct tcggcaacaa taataatact gtgcttcttg 2668741 ccgcgttcgt ggccgcgttt taagcgggca atgatttcgt gcatgtcata gtctgcctca 2668801 gggattaaga tcgattctgc gccccctgca agaccggccc acaatgcgat atcgccggca 2668861 tgacggccca ttacttcgat tacatatgta cgttcatgag aagtcgctgt atcgcgaatc 2668921 ttatcaattg cgtcaattac tgtatttaaa gctgtatcga aaccgattgt aaaatcagtg 2668981 cccggaatgt cattatcaat tgtacccggt acacctacac atggaaaccc gtgttccgtt 2669041 aattttttcg cacccatata ggaaccgtct ccaccgataa caacaaggcc ttcaatacca 2669101 agcttcttca agtttgctat ccctttttca cggccttcaa ctgttttgaa ttcaggacat 2669161 ctcgccgtat aaagcttagt ccctccacga tgtataatat cgcctactga tccgagttca 2669221 agcttttcaa tctttccgct gatcaatccc gcgtatccgt tgtaaatacc gtaaacttca 2669281 acgtcatgat agatcgcttt tctgactact gcgcgaactg ctgcgttcat tcccggggaa 2669341 tccccgccgc tcgttaatac ccctattcgt ttcattctcc attcacctca gcaacatata 2669401 tgattaaaca taacatgatc attgccctaa aaacaatgaa aagggatctc catcctccct 2669461 atgaaacctt acctattata caattaaata aattgttttt aaataaaatt taaggaatgt 2669521 cacaaaaaat aaacgtgagc caaaggcttc acgtttattt agtttacccc gatatattga 2669581 tcttcaaccg agactttgcc aattgcttta tatttttcat aacgctgctg aactaattct 2669641 tcttcgctca gcttcagtaa agtttttaac gattgtttaa gggtttcgtc catatagctt 2669701 gcctgcagct tcacatcatg gtgcgctccg ccttttactt ctttaatcat atgatctata 2669761 atacctaatt cttttaaatc cggcgcagtg attttcattg tttctgctgc ttttttagca 2669821 agactggagt ccttccataa aagtgccgcg gcaccttccg gagaaataac agaataagta 2669881 gagttttcca gcatatgcaa gtgattgcct acacccagac caagggctcc gccgcttccg 2669941 ccttcaccaa tgacgatgca gataacaggc actcgaaggc cggccatctc aaacaggttt 2670001 ttggcaatag cttcactttg tcctctttct tcagctgctc gtccagggta tgcccccttc 2670061 gtatcaataa aacagataat tggtctgtta aatttgtcag cctgtttcat cagacgaagc 2670121 gcttttctgt agccttctgg atgcggcatc ccaaaattgc ggactaggtt ttccttcgtg 2670181 tctttgccgc gctgatgccc gattaccgtt acagggaggc cgtggaactt cgcaatcccg 2670241 ccgacaatgg cttcatcgtc cccgtacgct ctgtctccgt gacattcaaa aaagtcggta 2670301 aacaggtgtt cgatataatc aagagttgtc ggacggtccg ccagacgcgc gatttgaacc 2670361 cggtcccacg gcttcaaatt tttgtaaata tcatcctgaa gcttagcgag acggtcttcg 2670421 agccgttcga tttccgcact tagatccata tcggaatctt gggtgaattt ttttagttcg 2670481 gcgattttgg tttgcagttc aatcaccggt ttttcaaatt ctaatcttgg agccactcaa 2670541 tgtcacctcc tgtttgatgc atatccagca gattttctaa cgtttttttc atatcgtcgc 2670601 gatgaataac cgcatcaagc tgtccatgtt ttaataaaaa ctcagccgtt tggaagtcct 2670661 caggcagttt ttctcctatt gtctgttcaa taatccgtct tccggcaaaa ccgatcagcg 2670721 cgccaggctc agcgaaattg taatcgccaa gggatgcaaa gcttgctgat acgcccccgg 2670781 tagtcggatg cgtcattact gaaataataa gaccctgttc ttcactgaac agttttaacg 2670841 cagagcttgt ctttgccatc tgcatcaaac ttaatacgcc ttcctgcatt ctagcaccgc 2670901 ctgaagccgt aaaaataata aacggaactt tatcagcttt tgctttttca atcgcaagcg 2670961 tgattttttc accgacgact gaacccatgc tgcccattct gaatgaagag tccatgacgg 2671021 cgacaacagc cgggtgtccg ccgatggtgc ccttgcctgt cacaacagcc tcgtttaagg 2671081 atgttttctc gcgatctttt tcaagctttt ccagatatcc cgggaaacca agcggatttt 2671141 ccgagagcat tccctgatta aattcctcaa aggattgttc atccatcaag ctttcgatac 2671201 gctgttttgc gttcattggg aaatgataat cgcagttcat gcatacccgc atatttttat 2671261 ccaactcttt agtgagcatg atttttttac acttaggaca ttttgtcata atgccttccg 2671321 gaacatcgtg cttcgcttga tcagacggta cggaagcata ctttttcttt ttcgtgaata 2671381 tatcctttaa caaatgatta cctccctttt gtgaagggtt ctcttcaccg catgtcatca 2671441 aacagataga cttgctaata actttaccga aactattgta ctttttttgt caaacgctgt 2671501 catcctcaat tcgacaactt tttattcgat gacgtgctcg gaaaggcttg tatgaaatca 2671561 gataaggtgt tgaaacgaca aggttgacag cgcattcaaa aataatgtta aacccggctg 2671621 aaattttttt aaggctaacc ccctaaaaaa atttcagccg tcagtttaac ttgagaacag 2671681 cgcgccggtc tccgccaacg cgctgccatt tttggaatga attaaaatta ttcaccaata 2671741 atcgtaagtt ttcttgtttt ttctgcgact tcctcagggt caacagtgat tcttgcaaca 2671801 cctgtttcca tcgcagcttt tgccacagcc ttcgcaacag caggcgcaac acgtttatca 2671861 aacggtgcag ggatgacata gtctgcgcta agctcatctt ctgaaaccag tgaagcaatg 2671921 gcttcaaccg ctgcgatttt catttcctcg ttaatatgag tggcacgcac atcaagcgct 2671981 ccgcggaaaa taccagggaa tgcaagaaca ttgtttactt ggttcgggaa gtcagaacgg 2672041 ccagttccga caacgcttgc tccggcttca cgcgcatctt ccggcatgat ttccggattt 2672101 ggatttgcca ttgcaaagat aatcggatct tttgccatgc tttgaaccat ttcttttgtt 2672161 aacgcgcctg ctacagagac accgataaat acgtcagcat caacgataac atctttcaga 2672221 gaaccgtctt tgcgatcttg gttcgtgaac ttcgccactt catttttgac atcgttcatg 2672281 ccgttcgggc gcccttcata aatggcccct ttggaatcgc acatcacaat gtcgcgaacg 2672341 ccataatgat gaagaagctt gataatcgca atgccagccg cacccgcgcc gtttgcgaca 2672401 actttaatgg atgacatgga ttttccagac agtttcagcg cgttcacaag acctgctacg 2672461 gttacaatgg cagtaccgtg ctgatcatca tggaaaaccg ggatgtttgt ttcttttttg 2672521 aggcgctctt caatgataaa gcagtttggc gctgcaatat cttcaaggtt gacgccgcca 2672581 aatgtcggtt ccagcaattt tacagtttca acgattttat caacatcgtt tgtgtttaaa 2672641 gcaatcggga acgcatctac gcccgcaaag cttttgaaaa gaactgcttt cccttccata 2672701 acaggaagcg ccgcttcagg gccgatgttt ccaaggccaa gcacagctgt accgtcagtt 2672761 acaactgcta ccatgttccc cttcattgta taatcatata ctttgttaat gtcttcatga 2672821 atatccttac acggttctgc aacacccgga gaatacgcga ggcttaaatc tttcgcattt 2672881 ctgacctcta cttttgattt agactccagt ttcccctggt tgactttatg caggtgtaat 2672941 gcttcttctc ttaatgacat tctcctaaac actccttatg gatatttttt gattcgtata 2673001 ctgctgcgtt gattgctgca ttctgcggag taaatctatc tgaatattta aacaggatca 2673061 cataattgct ccaattgtat aacaaaaagc gaatcgttac cactgtttta aaacgacgtt 2673121 tttttgaccc aacagctctt ttaagcgata taacacctgg tgatctgcat tgatatggaa 2673181 cgactcaggt agcttaatcg tctgtttttg cctttcataa tagagataaa cgcctgtttc 2673241 ccctttatgc tccagcaaaa tgcgcttaat ctttgccagg atctcctggc tgtgctgact 2673301 gctttctatt tttatataaa ccgatggcgc tttttctgca tccatatctt ctaataattc 2673361 tgcccgggac atgatgaatt ggatcttatc ttgtctaact tcacatttcc ccgcagtgaa 2673421 caaaagagcg ccttctctta aaacgggaga aagctgtctg aattgttcag ggaagactac 2673481 ggcttccatc tcgccggttt catcactgag cgttaaaaac gccatgtttt gacctgtttt 2673541 cgtccgaatc gttttgatct tcgacagcag aacgcctagt gaaagctgcc ttttgactgc 2673601 ccgctgagcc tgcagaatgg agactgctcc ttgcgcagtg agctgttttc ggaaggcgga 2673661 gaggggatga tttgaaaaat aaatgccaag cgtttccttt tcaaacgcaa gtaaatccac 2673721 cagaggaagc tcctccgtct ccacatactt cggcttaatt gaaaacgatt catctaaaaa 2673781 caatcccatt tggtcatcgt ccgcggcgaa tagctcagca tgttccaaag caacatcaat 2673841 ggatgcgagc agcgtggccc ggttttggcc gaattcgtcc atcgcaccag aaaagataag 2673901 tgcttcaagc attttgcgat ttacgctttt tgacggcacg cgaaagcaga aatcgaaaag 2673961 atcttcaaat ggtttctctt ttcttgcttt atatatatct ttgactgctg agacgcctac 2674021 actttttatc gcgcggaggc tgtatctgac agatccgttt tcaactgtaa acggaaaact 2674081 gcttttattc actgacggag gaaggatacg aatcccgctc ccctttgctt cgtaaagata 2674141 ttgagagatt ttatcctcat tgccaatgac gcttgtcagc aatccgcaca taaaatataa 2674201 cggataatga gctttcaaat acgcaagctg gcacccgatc atgctgtatg ccaccgcatg 2674261 gcttctgtta aagccatagt ttgcgaattt gacgattaaa tcgtagacct catttgcagt 2674321 gtctacagaa tactcctttt ttaagcaccc ttcaacaaaa tggcttcgct ctctgtccag 2674381 gatttctttt ttctttttgc tgaccgccct tctcaatagg tccgcttcgc ctaaagaaaa 2674441 ccccgccata cgggaagcaa tcatcataat ttgttcctga tacacaatga cgccatatgt 2674501 atcttccaaa atgctcctta aatcttcatg aggatagtga acaggcgccc gaccgtgttt 2674561 acggtcgata aataacggaa tattttccat cggacccggc cggtacagtg cattgaccgc 2674621 cacaatatct tctaggcccg aaggtttcag ccgtttcaag acgcttctca tccctgcaga 2674681 ttcaagctgg aaaatgcctg tcgtatcccc ttttgacagc aaggagaacg ttttgtcatc 2674741 gctgtaggaa atacttgaaa ggtctatttt aatattttct tctttttcaa tcattgaagt 2674801 gatggattca ataagtgtca gattcctcaa acctaagaaa tccattttta aaaggcccaa 2674861 gtcttcaaga tggtccatcg cgtattgcgt taaatagatc ccttcatgcc cttcttgaag 2674921 cggaacaaca tctgttaacg gttcttcact caggacaacg cccgctgcgt gggttgatgc 2674981 atgccttggc agcccttcta ttttccgggc aattgaatag acttgctgaa gcaggcttga 2675041 ctcccgaagc cgcttatcca gctgcggtga ctgctgtctc gcttcatcca gcgtcattcc 2675101 cggtcttgaa ggaatgagtt ttgcaagctg atctgcctcc ttcgggctga cgccgaatac 2675161 tctgccgacg tcccggagcg ccgcctttgc cgcaagtgtt ccaaaggtga taatctgtgc 2675221 gacgtgcatt gcaccgtatt tctgctgaac atattgaatg acttcatccc ttctagtatc 2675281 gggaaagtca atatcaatat ccggcatgct gacgcgttcg ggatttaaaa atctttcaaa 2675341 cagaaggtga tgcttaatcg ggtcaacatc tgtgatatac agcacatatg ccacaagaga 2675401 acccgccgca gaaccccttc ccggtcctgt aacaatccct ttttcatggg cgtgcttcat 2675461 aaaatcccac acgatcagaa agtaatcgct gaacttcatc cgcttgatga catcaagctc 2675521 atattgaaga cggcgaaggt atcgttcatc aggcttgccg aaacggctgc ggagtccctc 2675581 catacagata tccgttaaat aatcatcagc ggacgttccg tctggggtcg gaaaagacgg 2675641 tagacgggtc tgcccgagac tgacgtcaac ccggcattgt tccgcgatct ctacagaagc 2675701 ttgcagtgcc tcgggatgct ctcgataaat gttttgcatt tcttcgagtg gtttcaaatc 2675761 gagatcaggc aaatcttcag cgggtgcatc cgtcagtttt tcccccgctt taatcgcttt 2675821 caaacaacgg taggcagcct tatcttcctt ccttatgtaa tgcacatcgc ctgtggccgt 2675881 aacagggata cccgtttctt ctgacagctt tagaatctgc tcagacaaga cttgattccc 2675941 tttaaaaggc tgataggaga aataaaaagc tccctttccg aatatagact gaaattccag 2676001 cgaggcttga gcagcctgtt cgaacagccc tccttcaaga agcgtttcaa tatatccttt 2676061 ttcgccgggc gttattgcga taatcccttc tcgataactg tgaagccatt tcggcttcag 2676121 tccgcctttt gatttagatt gcagaacgct gctgattttc agcaggtttt gatagcctgt 2676181 attcgatttt gccagcagga cgagcgggta tgcttcaagc tcgctgtcat ctgtaaaaac 2676241 agaagccgtc aaaccgatta ttgggttgat ccctctcgcc ttgcaagctt tataaaattg 2676301 aatagctccg tacatgacat gatcatctgt cagcgccaaa gacgcatatc cgagcctgtc 2676361 agcttcactg acgagttctt ccacagccgc ggcgctgttt agcaggctat acccgctatg 2676421 cacttgcagg tgaacaaaag acatgctatc acctctttct cattacgatc catttcttcc 2676481 ttcattataa ggccggtttc caaaagaaac aaatgttctt ttttgactca tcatcatact 2676541 tgtcctgaaa gctcaatatg atataaaagg tgaggtgata aagatggatc aggaagcagg 2676601 atttatggtg aattttatca atagctactt cattgcgtta ggggtgctga tcgggggcgc 2676661 actcatcgga gggctcggag catacttggc aggcgaaccc ccgcttacag ccattacaaa 2676721 gcttgccaac cggttaaaaa tatgggcgct tgtcgcagct atcggaggca cctttgatgc 2676781 ggtatacagc tttgaacgcg gcatactcga aggcaatacg agagatatct ttaaacagct 2676841 tcttttaatt atttcggcca tggggggcgc gcaaagcggc tggcttatta tatcatggct 2676901 gacccaggag catctttctt catgagggtc ccccagcatt acaaaaaacc gggatggcag 2676961 cgttttttcg cgggaatgat gtgcggagcc gtaatcagct ggttcttttt cctgtttact 2677021 tacggaacat tccaagagga gcaggtcagc ctcatcgaaa agcaaaaaga gcatgtaaaa 2677081 gacttgaaca atcaaatttc gatctatcag gaagacctcc ataaactgaa tgaagataat 2677141 aaaagaaaac tgctgattca aagcgtcagc gtcaaattgc tgaatgggga taaatataaa 2677201 atatcacagc cggataaaac gaaattcgag gagcatgtaa aggatgatat ttcagaggtg 2677261 attacaaaag acatagagag cgtctatcaa acaaaggatc tcttgaagcg gacaattgaa 2677321 aataaagtct atatgatcaa tgaaaaaaaa tacgaggcaa ccgtcagaga attgattatt 2677381 tatacgaggc tgacagtgga acttgaaatt tctttcgcca cataattatg gatttttttt 2677441 aaattctcca aacttctgtc gctttttccc attctttttt ataaactata tgtgaggctt 2677501 aatggcgaaa ggaaggagga agggaaatgg aggtttacag tgaccgtcag ttagcaaaag 2677561 atcaagcagc ccgtctcaga caaggttttt ctgcatatgc cgaaacaaac tcactcgctt 2677621 ccctcatcaa aaaagaactt caatcacaca atctccaagt ctacgaggac cttactgatt 2677681 tcggctgctg gttcatcccc gtcacagatg aacactaaga gagagggtct cccctctact 2677741 cgtgttcttt acataatgtt tccagatcag ctaaaatacg atcagcttca tcccagctgt 2677801 aaatagaggc gcctgaagct aacggatgcc ctccgccgtt atatttccgg gcaagtccgt 2677861 taatgacagg ccccttcgaa cggaatctga ctctgatttg atcgtcttct tctacgaaaa 2677921 acacccaggc gcgaatacct gagatattgc caagcgtccc gacaagctgc gacgcttcag 2677981 aagccgttgt gccgaatttt tcaagcgtat cctttttgat gaaaacagaa gccgccccgt 2678041 tttcggacaa agacacattt tgaaagataa agccgttaag cttcaccaca ttcagttttg 2678101 tttcatacaa ttgattaaat aactctgagg aagagaatgg atactgaatg agctcgcctg 2678161 catattttag tgttttttcc gtggtattcg gaaataaaaa gcgtccggta tctccaacaa 2678221 tgccggcgta gatcagctct gccgctttcg tattcagctt ccagccgtgc tcttttcctt 2678281 ctaaatacag ctcgtaaatc atttcactta ctgagctggc gcttgtatcg acccagagaa 2678341 ggtcaccgta tggatcttcg ttcggatggt ggtcgatttt cattagtttg gcgcctgaag 2678401 gataacgctg atcgtcgatt ctttcctgat ttgccgtatc gcagacaatg acaagtgcgc 2678461 cttcatatgt ttcattgtcc acctcatcaa gggaatataa gaaagagagg gacggttcag 2678521 gcgtgccgac cgcaaaaata tttttttcag gatatgtttc acgcaggatt tccgtaagcc 2678581 cacactgtga tccgtaggca tccggatcag gacgcacatg tctatgtaag ataatcgtgt 2678641 catataatga tatggttctg atcaattctg ttttcatttg atactccttt attgttttta 2678701 ttcattaaat cacattctct gccgacggaa aagaaaaata acgtcaaaac caagcccgtt 2678761 tttgtataaa atggggttgt aaacttttac gatggaggat ttcatttatg ctggttcttg 2678821 tttttttgat tgggctttca gcctgctttt atgtgtacta taaagtaaaa ggcgtacggg 2678881 caaagccatc tttggcaaaa gaaatatgtt cagcaaaatc aagcatggcc ttagggtcac 2678941 tagtcctgtt ctacgggctt aaccaaatga tattattcca ttcagtatta acgttagtaa 2679001 tcggcggtat ctttatcgtc ataggagcag gaagcgcttg ggcaggttat aaagccttca 2679061 ggcattacaa tccccttcac gccaaagaag ctgaaagaga tcacgcgtaa ggggcgcctg 2679121 aacgtccctt agcttctttc catcagctga accatcagca tcgctttaga cacgatatga 2679181 ccttggctgt gcacttccac ttccattttc ccaaactttc tgccggcctc caagatgcga 2679241 ggtttgactt cgatgactga ttccatctgc acaggcttca aaaagaagat ggtgatgctc 2679301 tctatgacga gttcgccgcg ttttttcgag cgcaaaaatc ggtttgccgc ttgcgtcaaa 2679361 atggtcgtaa atacgccata agaaatggtt ccaagctgat ttgtcatttg cggcgtgact 2679421 tcatactcgt aaaccgtttg atcttcttta tcatcaccct catctttaaa cccccttgaa 2679481 acgatatcat caagcttctc cccgacctgc ggctgctttt gaatcatttg aagagctttc 2679541 aatacgtctt ggcggctgat catgccgatg agtttttggt ggccgtcagt gacgggaagc 2679601 acttcgatcc cttcccatac catcatttgc gcagctgaag cgacagatgt tttcccaata 2679661 accgtgacgg gatttttggt catgactttt tctatagatg catttcggtc atggccagca 2679721 atatcttttg atgtcagaat gccatggatt ttcatttgat cgtcgacaac cgggaagcgg 2679781 ccgtgccccg tttcaaaatt tttctcatac catttttcaa gtttatcctt aggcgaaaga 2679841 tataccgtgc ggtcagcagg tgttaggatg tcctccacca aaacaatttc ttttttgatc 2679901 agctggtcat atattgcccg gttaatcatc gcggcaactg taaaggtgtc atagctcgtg 2679961 gataaaatcg gcagttcaag ctcatctgcc agctgcacaa tgctgtcatc cgtgttaaag 2680021 cccccggtca ccaatacggc cgcgcccgct tcaagcgcct gcctgtgtgc attgattctg 2680081 tttccgacaa tcaaaagatt ccccgctgcg gtgtaacgca tcatcgcgtc aagctccatc 2680141 gcgccgatga cgaatttatt caatgtctta tggagccctg ccctgcctcc gagcacttgt 2680201 ccgtctataa catttacaac ctctgcatag gtaagctttt caatgttctc ttttttcttt 2680261 tgttcaattc tgattgtgcc cacacgttca atcgtgctga caaacccttt attctctgct 2680321 tccttgatcg ctctgtacgc ggttccttcg cttactttca tttcctttgc aattcttcgg 2680381 acagaaattt tttcaccgac aggcagtgaa tcgatatacg ttaaaatttg ttcatgcttc 2680441 gttgccaagc ctttcacctc taaggacagt cttcttgttt ttattataag gtttcaaagg 2680501 atttatacgc aatgaggctg gaaaataaaa aagaagcccg accggcttct tacagcgttg 2680561 atttcgttcc agtcaaacgc aaggaccacg tgattccttt tacatcgtaa agcggaaaaa 2680621 cctttatttt tcttttaaat ggacatcaac cgctgtctta acaatatttc gattccctat 2680681 tttagataaa acaaataaaa ctgcggatag ccatatcgcc cctatggccg tatagatcaa 2680741 tggatgaaca gctgtgtttg cgatccattc atttattaat gttctggcat ttaccagaat 2680801 aataaatcct cctacaagca cacccatcaa ttgcggatga aacttctgca ccagccatgc 2680861 tgcgataggg gcagcgataa ttccgccggc cattagtgaa aacacccata accaattgac 2680921 gtcctcccat cctaatgaaa taagaaaacc ggcggttgca gatacggcga tggcaaattc 2680981 acttgtgtct acagtcccga caactttcct cgggctcaag cctttgcggg ataataaaat 2681041 cggagtggtc accggtcccc agccgcctcc gcctgtggca tctgcaaaac cagcgatcac 2681101 tcccaatggg atggattgtt ttcggtttaa cggcacatgc ttcttctcaa gagccggctt 2681161 atattgaaat aaaaacctga tcaatacata tccgcccaga aggagcaaaa acaaagaaat 2681221 atagggtttc gccacatctc caggtaattg gctgaggaat gccgcgccta aaaaagcgcc 2681281 tatagagccg ggaatgacaa gctgataaac ggtttgtttg tcaacattgc caaatttaat 2681341 atgcgacact cccgatgcgg cagtcgttac gacttccgct aaatggacag aagccgaagc 2681401 cacagcaggt gtgatgccaa acgccaataa caaagaagtt gaggtaaccc cataagccat 2681461 acctaacgaa ccgtctatta actgcgacaa taaaccaata aatgcaaaaa cgattaattt 2681521 cttcatcaga acaccccatc tatatcaatc agatattttt gactcttcat tcgaatctaa 2681581 caatctcttg gcgctttcat ataaaaaata agaggctttg ataattgcag tttcatctat 2681641 tgtaaatgca gggtggtgcc aatcatgatc accgtctgtt ccaaaaaacg caaaggatcc 2681701 cggaatatgc tcaagataat aagcaaaatc ttcccccgcg gttgatgggg cgggatcaat 2681761 gacttgaagt ttcgctttat gtgcagcgtc tcgcaccagc cccgtaattg cctcatcatt 2681821 acaaagcggc ggcggtccgg aatgccactt cacatttgcc tttaacgaga aagcggcaga 2681881 aatctgctct gtgactgcaa aaaaacgctg tttcacttga ttacgaacct ctgaatcaaa 2681941 tgtacgaaca gtgccctcaa tgaccactgt atccggaatg acattccaag tgctgccgcc 2682001 gttgattttc cctacggtta aaatcgcgct ttgcagcggg tttacatttc tgcttacaat 2682061 cgtttgcagg gcgacaataa gctgagaggc gccgataatt ggatcaaaac cattatgcgg 2682121 caatgctgca tgagcacctt tcccttctat ctctacttta aatcggtcaa cagcagccat 2682181 aagcgggcct gtttttaacc ctacagtccc aaccgcgata tccggtttat tgtgaaggcc 2682241 aataaccgca tcaatgccat ccagttggcc gtcctctatc acttttgtag cgcctgcacc 2682301 cgcttcctct gctggctgaa ataataaacg aatctttcct ttcagactgt cttgattttc 2682361 cttcaataaa aaggccgcac caagaagcgc tgccgtatga aaatcatgac cgcacgcatg 2682421 catgatccct ttatgtttag acgcataagg caatcctgtt ttttcttcaa ttggcaaggc 2682481 gtcaatatca gccctcaaag caatcgccgg accttctgac tcccctgcta tgtctgcgaa 2682541 cacacccgtt tttagagcag tagggcgaat ctgtatcccc ttttctttaa ggcatttttt 2682601 tataaaagca gttgtttcaa attcttcttt tgacagttca ggatattggt gcaggtgccg 2682661 gcgaatgccg atgagctgct tttctagcgt tgagagattt acgggattag actcctcttt 2682721 caacgtcagg atgtcatttc ctgtagtctg atatggatag gagccttcta tatttctcca 2682781 ataatccaaa gacatatgtt ccgctccttt ccctatccca atatattttc ttcagactct 2682841 tcaacataag atgaaataaa tcggttcaat ttatcagcaa gaccgcccgc cccaaatctt 2682901 atatacttgc tggaaacttt cggattatct tctttcaaaa agcttaaaaa agataaaata 2682961 taaatgcgcc tgtaagctac ttgtgtaatt ccgtactcaa aaaaccagtt atcaatgaca 2683021 ttgtatacgc ctcggttgac gccatatagg ttattacatt tcttgtaaaa gcagagatcc 2683081 ggaagattta actcctgatg ggaaagaagg ctttcttttt tgtttggtgc cataatccca 2683141 atcagctcaa agcgttttgc aacgcacgaa atatcctttt taatttgctt tgttaaagac 2683201 tccaaagaat caaaccttct ttcttctcta attttaaaga gaatgctgca ttcgattttt 2683261 tctccataaa tgtctctatg aaagtcaaac aaaaaaatct ccaatgtctt ttcaaggtta 2683321 gagcccaccg tcggtttcac accgatattc ataaccccta aatgaaattg atgattgact 2683381 gtcgccagaa ccccataaac tccattacgc agcccatgta tttttgcatc tacatttgcc 2683441 gtggggaatc caagctttct gcctaattgt tttcctttca caaccgtacc ggcaatgatc 2683501 gtcaaaaaag tcagcctcct ctctcagctt ccgcattcga tcagacgaaa cctaatgatg 2683561 tgatgaatgt aaaacggatt gatgctgcgg aatgccaaga ccgagatttt cccgcaatgt 2683621 cccgccgcga taatcttgac gataaagccc tctttcttga agaatcggaa tcaccttttc 2683681 tacaaaagca tcaagtgttc ccggtatatc cgacccaacg ataaacccat ccgccgcctc 2683741 agcgttgaac caagtttcaa ttaaggatgc gacacgctct ggtgttccga tgaatagagt 2683801 ccgtggaaaa gccatttcct gtgctacctc ccgcaatgtc agatttctgg cttttgcttc 2683861 tctcttaatc cggtctgttg tgctttgaaa cgcattcttt cccacatcgc caatatcggg 2683921 aaatggctca tccaacgggt aaacactcag atcataatca tcaaaaaaac gggccaaata 2683981 agtaacagca ttttcaatcg gtatcaattc tgcaaattca cgatacttct tttccgcctc 2684041 ttcttccgta tctgccacaa tcgggctgat ccctggaaaa atccgcacac ttgaaggatc 2684101 acgcccttca tcagcagctc ggcttttcac atccgcataa aacgcttttg tctcttctaa 2684161 tgaattggaa tgggtaaaaa tcgcatccgc atttttagca gcaaactgcc ggcctgtttc 2684221 tgatgaaccc gcttgaaaca ctacaggctc tccctgctta gagcgcccga tattcaaggg 2684281 cccctctact tgaaaatact ttcctttatg attcaggcga tgaagcttcg cctgatcgaa 2684341 aaactgccct gttttcttat tgtgtataaa tgcgtcatgc tcccaggaat tccacagccc 2684401 gcgcacaaca tccaaatgct cttgtgcgat ctcgtaacgt tcagtgtgtt ctggcaaatt 2684461 agacttacta tggttgcgcg ccgctccttc ctgcggcgaa gtaaccagat tccagccggc 2684521 cctgcccccg ctgatatggt ccagcgacat caattgtctg gagatagtga atggctcagt 2684581 aaaagatgta gagaacgtcc ctactaaacc aatatttttg gtaaccgatg ccagcgcaga 2684641 taaaatggtg atcggttcaa aacggtttaa aaaatgagga atcgattttt cagaaataaa 2684701 taagccgtct gcaatgaaaa taaaactaaa caaacctttt tcagctgttt gcgccttttt 2684761 catgtaaaat tcaatattcg tgctggccga gggatcaaca tcgggatgac gccagccgtc 2684821 agttgttccc ccgacaccgt gaatcatggc tccaaactga ataaaatctg cacgtgtcat 2684881 ctttttgcct cctttatctg tgcatgatta gcaagtgcaa gatcaaggtg ttcaatgccg 2684941 atttcagtta tcccttgata ctgattgccg cgcccgattt cgaccacagg cacatggcgc 2685001 accccatatt tcacctgtaa aatatcccga agcttttctt tctctgaaac atcgatattt 2685061 tggaacggga accctttttc attcaaataa ttcttgactt cctcacaata cgaacagcct 2685121 tttttactcc aaaccacaat gttcacaaca tcactcattc ttctgtccct ccttaacgtt 2685181 ttgcagctaa aactgcatcg ctcagcagct gataagacag ctgtttttct acagcatttt 2685241 tgatcggtgt aaaaataaca aaatcattga ttttgtatgt gcctgataaa cgtgttaatt 2685301 cttctgccac ttcttccttt gttccggcaa taatcccggt tttttgcacg atgatgtcat 2685361 agggctctgt gacgttttcc agataggcct cagcctgttc gcgggaaccg acgttgacct 2685421 tacgcccgtc tttcaaaacc acttttatcg attcacgcga cacaatatgt ttttccgctt 2685481 cttcttttgt atgtgccgca aaaacagcgg gggcaagatg aaattcagcc tcagatcctg 2685541 gcgggagatg cgcgtcaaat gctcggcggg cttccttcag cacttcctct tcaccgttaa 2685601 taaagtaagc aaagacaaaa gagattccca gttttgcagc agaaatggca ctctctgtgc 2685661 ttcctcccaa tagaaaaata cccggcttcc gatcaacctg cggcctagga cgcaatgcgg 2685721 catagcggtg ggtatcagga aaatcatccc gaacgaaatg agtaagctcc tccagttttt 2685781 catcaaactg acgcaccggt tttttatatt cggcctgcag cgcgtctgtg gacagctgaa 2685841 acccgccggg cgctttgccc actccaagat ctatacggcc gggagctaac gctgatagaa 2685901 gatggaattg ctccgctact ttataagagc tgtaatgctg cagcatcact ccgcctgatg 2685961 ctaaacgaat ttttcttgtg cttgcagcaa gatagcctaa aagaacctcg ggtgcagacc 2686021 ctgcaatctc atcattgttg tgatgttcgg ccacccaaaa tcggtgatat ccacattctt 2686081 cagccatttg tgccaatttc actgtatgct gtaatgtatc agctgctgtc tccccttcac 2686141 caatcaagct ttggtctaaa atacttaagc ggatcatatc accggctcct ttatgtgttc 2686201 ttttggttca aataaatatt ccggcgaaac acggcggaga aactgcctcg ttctgtcttt 2686261 tttggtatgg cggaagactt cctccggggt tccttgttca acaatgactc cttcatccat 2686321 aaaaacaact tgatcagaga cccttcttgc aaactccatt tcatgtgtaa caacaatcat 2686381 ggtggctccg gttttcacga tttccagcat tacctcaagc acttcaccga ccagctccgg 2686441 gtcaagcgct gccgtcggct catcgaacag cagcacatca ggatgaatgg caagcgccct 2686501 tgctatccct accctctgct tttgtcctcc cgataactga ctcggataag cgttcaattt 2686561 atcttgaagc ccgacctttc tcagttcatt ttccgctacg gcatacgcgt cttgttttct 2686621 cattttccgg gcaatcgtca agccctccat gacattttca atcaccgttt tgtgagcaaa 2686681 caggtggtat tgctgaaata ccattgccgt ctgttttctg agccagtgaa cctctttttt 2686741 ggacggaaag cggcaattaa tcactttgtc atgtatagaa atgatccctt cgtctggacg 2686801 ttctaataaa ttcaggcacc gtaaaaaggt ggttttccct gatccgctcg gcccgataat 2686861 cgtcacaact tctcccttgc gtaccgtgag atttatccct tttaatacat ggtggatgcc 2686921 aaactgttta tggatatttt taatctcaat cataaagtgc ctccttgaaa tctggctgcc 2686981 tttctctcta atactccatt tgcggattct aggattagag tcagcaccca atagataatc 2687041 gctgctccga taaacgcttc taaaaatgca taattatcag aagcaacgat agtcgccgtc 2687101 cctgtaatct ctgggacagc cactatagcc gcgatagagg tggtatgcaa aaagccgata 2687161 cccaaatttg tgaagtttgg gatggaaacc ttcagcgcct gcggcaatat tacacgccga 2687221 aaggtttggc tgtatgtcaa gccgattgaa taagccgctt cgacctgtcc ggtatccatc 2687281 gccagaatgc ccgaccggat gatttctgtg agataagctc cggcagttaa agacaaggcc 2687341 atgatgacaa acatggagac cggtatctca ttagcggacc agccgagatg aaaaaaactg 2687401 ctgacttgat ctgcaacagg cggtatccct aaataaatca acataatgtg aagaattgca 2687461 ggtgtacttc gaaagaaaga cacataaaac cttgagcaag ccaccaagcc cttaattcta 2687521 aaaattctaa caattatatt tccaagagcc acgagaaatc caaacacaat cggcaaaaca 2687581 gccatcatca atgtcagagg aatggtcttt accatttctt tcatggcgga aacgataaat 2687641 ggaaagtcaa attgcaatct tctcccccct catccgaaga aatatatcaa tgtatgttca 2687701 tgtcaaaaac agtaacaatc cttgtttgat tcttcttgat tcgtttttct gccactcgaa 2687761 agaaccattc gaataaaacc gctacagcat aataaacaat cgatagcgca atgtaaactt 2687821 caagagaatg gttgcttgag gtaatcagtg tttggcccct tccggacata tccataacac 2687881 ctattgaaaa ggctagagac gtatctttta aagaactgat caccatgttt cccatattcg 2687941 gaaacgcctg gacaagtgcc tggggcagaa cgattcgcct gaaggcctga ctaccgctta 2688001 agccaatact gtacgccgct tccgtttggc ctttatctac actgcccacc cccgctcgaa 2688061 tgatttctgc ggctgccgct gcattgctta acgcgtaggt tgcgacagca gcataaaacg 2688121 ggtccatttt tgatgtatca atcccgataa gccccgtaag cgccgggatc ccgtaaaaca 2688181 cgatgaaaag ctgcaccatg ataggcgttc ccctgaaaaa cgagatatac acttttgcca 2688241 attgatttac aattggaata ttatagatgc ggggcagtgc cagaaagagt cctaatacaa 2688301 aaccgaaaag caaggacagt gttaaaatgt ataatgtaac cggtaaataa gcggttaacg 2688361 tcggcacaaa atctccaatc atgttcatat caaacgcttt ttccatcact gctccctctc 2688421 tttttaccta atactgctct ttggaatagt cgtcaccaag ccatttcaaa ctgagccttt 2688481 tcaacgttcc gtcatcaatg atttcctgta aggctttatc aatatcgtca cttaacgttt 2688541 gttcattttt gttaaacata aaatacactt tggcatttga aagcacatta ccgacggttt 2688601 tttctttaat agtgctcgtc ttgttttgaa agtctactgc aaaaggcgtt gagatcgttg 2688661 cgtccgcacg ccccgatttc agctgattcg cagtctcatt tgcgccttgg ccctcatagg 2688721 caatctcaaa cggccgtcca ttatcctcat tccatttttt cagtacaagc gctccgttgg 2688781 aggttgcact cgtaatcacc cgttttcctt ttaagtcttc aattccacgg atcgtatcgt 2688841 tattttgaag cacagtaatt tttaaaggaa aatggttgta agcaaccttg ttaaacagaa 2688901 attttttctc acgctctttg cttttctcca tttgatgtgc cacgatatcg actttatgct 2688961 gtccgaggct gacaagcagg ttggaaaatt ccatcgtttt aaatgtgaat ttataatgtg 2689021 gcaggcgctt atcaagctct ttgatcagtt cgacatcata accggttaaa tcgccttttt 2689081 catcgataaa gcaaatattc ggaaattggg ttccagttcc gaccgtgatc gtctgtacct 2689141 tcttttgccc ggctcccgtc gtttgactgc ctgcaccgca agctgacaga actgttataa 2689201 gcgaaaataa tattgccatg aatgctgttt tcgttttcat ctcatcgccc catttatttt 2689261 tcaaaacttg attttgaata atctgccccg agccattttc ggcttagttt ttttagcgtt 2689321 ccgtttttct ccagcttttt aatcgcttga tccgtgtcat ccgccaaggt ttggctgcct 2689381 ttattaaaca taaagtacac ctcggtatct aataacacgt caccgactgt cttttggcgg 2689441 aaggcgtgcg ttttattctg aaaatcgacg gcaaacggtg tagctatcgt tgcatctgcg 2689501 cgcccggttt caatttgatt ggcggtatca ttgcttccct gtcccgcata tttcaaatga 2689561 attgggctgc cgtgcgtttt gttgtacttt gtaatataat ctgccgcatt tgacgtggcg 2689621 ccaactatga ctgtttttcc gtgtaagtct tttaatgtat gaatcttgtg attatcctct 2689681 ttcaccgtga tgtacatcgg cgagtagtta tatgggactt tatgatacaa aaaacgcttt 2689741 tctcgttctt tatttttggc catattgtgc gcaatcacat caattttttt atttccgaga 2689801 ctcgtcagca aatttgagaa atccatcgtt ttaaattcaa atgtatattg aggcaactcc 2689861 ttatcgatgg ctttcatcac ttcaatgtca tacccggtca attcaccttt ttcatttaaa 2689921 aacgcaatat tcggaaaatc tgttccagtg ccgactatga ccgtttgagc ctgacgatct 2689981 gttttgttat ttgtttgcga acatcccccg ccaagtaatg caaacactga cagcagcaaa 2690041 accaatcctt tacgcttatt cataggctgc ctcacatcat gcccagctgg gcgcacctaa 2690101 aagcgttggg ttaaatcgtt ccggaatcag aaccttgtgc atcatcacac ctatgtcccc 2690161 gtctttttcc tgctcaaaat acacttcata ccctctcctt ctgtacatgt cagcaagcca 2690221 aggatgcttg cgcgccgatg tgccgagtgt cagcgcagga gccttcagca tatctcgaag 2690281 cactttttct tcaacatacg taagcagctt acttccggcg ccttgccctt tatattccgg 2690341 cagtgtcgca aaccaccaca caaatggata ttttgaagga ggcgtctcac tctcccacgg 2690401 gaacctgatt gtaatcgttg aaatcagctt cccatcccgc tccagcacaa tcgctgaatg 2690461 atgttcaata ttttctgata ccatttggat atcagctctc gtggatggcc aatcaatatc 2690521 cagctgccga atgggctgaa atgcgctgtt aaccagtttc aacagctccg atgcatcttc 2690581 aacagttgcc agtcgaaaaa tatcatcact catttttgtc actcctcttc acaaaatata 2690641 taattcctat ttgtttacta agcttttatt gtttatacta taaagcatac tctgatcttt 2690701 gactaatcaa aaaaagtaaa ccttcacttc agtaatttta atgatgaaaa acaggaggga 2690761 gcacattgga gttacgctca atcaaaacgt ttcatacgat tgtaaaattt ggaagcttct 2690821 ataaagctgc agaaatactc aactactcgc agccgacgat atcgatgcgt atgaagcaat 2690881 tggagcagga tttaggcgta ctgctgtttg aaagaggaaa aagcctgcag ttgacaaaag 2690941 cagggaagct tttttatgaa cgaacaggag atcttttgat gcaatacgag gcgcttaaac 2691001 acaacctctc cgacttaaag gaagaagagg caggcattat caacataggg gtttcagagc 2691061 caaccgccag tctgatattc cccgagattt taaaggattt cttaatggat tacccaaaga 2691121 taacggttaa tatcaaggtt gatgacgcca atacctgcag tcaaaagctc ttagacggga 2691181 cgattgattt tgcagtctgc ggcgagccgg agctgattct tgaaaattac taccatccat 2691241 ttttttatga cacattaaat gtgattgtat ctgatcaaca tccgctcgct gagaagaagg 2691301 ctgtccattt gtctgattta gcagaagagc gcttcatatt tacgcccgcc aattgcccca 2691361 ttcgcttaca aattgaacag catttacata gagaactcgg gaatcgctac aaaaaaatgg 2691421 agctcacaag cagcatgtca catgaatatt acgtacgtga aaacatcgga atttcaatct 2691481 ttaccagcac cgcacattct aaaccgttca acggcactaa agtcattcca attctgaacc 2691541 tggatatcac cccgcccata gggctgttga caaatcaaaa agaagttcat tttgaccgcg 2691601 ccacgaagga cttgatcgcc cggataacca aacgttttca gcagcgcagc aaagaattgg 2691661 aaggaacctc tgataagacc attacaggat aactgaaaaa ataaaaacca cctcctgatt 2691721 catcaggaga tggtttcacg gtttaaagct cgatcgtctc accgaccgac atgactttgc 2691781 cgactccgcc cggcaggctg tcagcgaatg cttctgggtc ttgttcgatg accgggaatg 2691841 tattgtaatg caccggcacg acctgttttg cgcgcagcca ttcagcagca agcttggcgt 2691901 cttcaggccc cattgtaaag ttatcgccaa tcggaaggaa agcaaggtcg atatgattca 2691961 attcgccaat gagtttcata tcagagaaaa gtgccgtatc gcccgcgtgg aaaatcgttt 2692021 tatcttctac agtcagcaaa ataccggcag gcatgcctgt gtaagtgatc gttttgtttt 2692081 cttcatctgt gatggctgat ccatgaaagg cctgtgtgag cttcactttt ccaaaatcga 2692141 actggcggga gccgccaata tgcattggat gaacattcaa gcctttccag cctaagtaca 2692201 cagcgagctc gttcggggct ataaccagcg cgttattttg cttggcgatt tgttcagtat 2692261 caccgacatg gtcattgtgg ccgtgcgtta gtaagatgac atccgctttt acatcctccg 2692321 gctttatatc cgttaatgaa ttccctgtta aaaacggatc aaaaataata tgatggtcct 2692381 tcgtttccac tgtgattaca gaatgtccgt gatatgtcac tttcatttct ttcacctcgt 2692441 cacatgattt tgtttttttt attttccctt tttaaaaagc tgaaaaactt atgttgtttg 2692501 attcttgtta atgacattga ggcctccggt ggcttcaatg acagtccctg tcacaaggtc 2692561 tgagttctcc tcacacaaga aagcgataat cctggcaata tcctcgcctg taccggatct 2692621 tcctatcggc gttttttctt tgccgattcg cattctggct tcctctatcg atgcttcttt 2692681 catgtcgccg acaatgtctc ctgggcaaac catgttggcg gttatgccga attcggcttc 2692741 ttcaatggca attgtcttcg tcaaagaagc caagcccact ttcgcagcgc caaatgccga 2692801 tcggtgaagc cagccgggcg cgtgagccgc accttggaat ccgtacgtaa taatgcgtcc 2692861 aaattgctgt tttctcataa taggaataac cgctttgaat aaatgaaaga cggcgcttaa 2692921 atttccttcc agcatgccat accattcatc atcagtataa tcggctaact ttttacgttc 2692981 aaatatgtat ggtccagcgt tgttaatcaa aaagtcgatc cttccgaagc ggtttaaggc 2693041 agcctctgca atacgcagca gatcttcttt tttggtgaca tcacctttta caaattgcag 2693101 ccggtcaaga caatcgggac aggcttcctt caggcggctg actgcctcct catcctgtct 2693161 gtaattgact gttactgaat acccctttgc aagcaacgtt tcagtcactt tgcggcctaa 2693221 acccttcgaa ccggcagtaa ttaaagcatg tcgcacatga atacctccca aagcaacgtc 2693281 gccgctttca ataaagtgtt tcttcttcta ctttactata aaaggcttgc aatatcactt 2693341 tttacacttt ggcatacaaa aaaagctgcc tgtacagaca gcttattctg caggagatga 2693401 agactcctga tcaggcatat cgacataacc gctttgatat gcttctgaaa tgagccttgt 2693461 tgtctcctgg ctttcttgtt catcataaat atagcgttcc ggttcttttt tcatcattct 2693521 gcctcccatc attatagagg taggttggct ataatgacgg gattttatga aggaaatttt 2693581 aacaaactcc tgctgccacg caagctttcg ctttttcaag cgcctgttcc acctgtttga 2693641 atccggtgcc cccggcgctc attctttttt caactgcgta gtaagggtct aacacagtgt 2693701 aaatatcttc ttcaaatagt gtgctcgcct gctgaaactc gccaaacggc atatcgctta 2693761 aatagatccc tctttcgatg catgtgtaca caagtttccc gaccacttca tgcgcttctc 2693821 tgaacggcat tcctttttta gctaaataat cggccagttc cgtcgcgttt gaaaagtctt 2693881 gttttgttgc ttgcttcatg acgtctttgt ttacagtcat tgtttggatc atgcctgtga 2693941 agatttgcag gctgccctcc accgttttca ccgtgtcaaa catgccctct ttgtcttcct 2694001 gcagatcttt gttgtaagcg agcggaagtc ctttcatgat cgtaaacagc cccatcatat 2694061 cgccgtatac gcgtcctgtt ttgccgcgga tcagctccgc catatcaggg tttttctttt 2694121 gcggcatcat gctgcttcct gttgcgtacg tatcgtcaag ctcgatgaat ttaaactcct 2694181 gcgagcacca taaaatgatt tcttcagaga aacgggatag gtgcatcatc agcatactgc 2694241 tgttgcttaa aaactccaaa atgaagtctc tgtcgctgac gccgtccaag ctgttttcat 2694301 aaatggcatc aaagccgagc agttccgctg aataatcacg gtcaattggg aaggttgttc 2694361 ccgcgagcgc cccgcagccg agcggagatt tgttaatccg cttcattgaa tcctgaaaac 2694421 gctccttgtc gcgctcaagc atccagaaat acgcaagcag atggtgagcg aatgaaatcg 2694481 gctgggcgcg ctgcaaatgt gtgtagcccg gcagaatcgt ttcaacgttc gcttccgcct 2694541 tttcaatcag cgcactttgg aatgcctcaa tcagctcgat gatgtggccg acatgattct 2694601 tcaagtataa atgcatgtca gtcgccacct ggtcattccg gcttctgccg gtatgcagct 2694661 tgccgccaag aggaccgatt tcgtcaatga gcattttctc aatgttcaaa tgaatatcct 2694721 cataatcgac tgagaattcc aatgctccct cctctgcttt ttgcaaaagg gtattcaggc 2694781 cctctcggat tttcaactct tcttctgctg tcagaatacc gcattttttc agcatggcag 2694841 catgtgcgag agaccctgta atgtcttcag caactaaatt ttggtcaaat gatatggacg 2694901 cgccgaactc gtcgacccat ttttccggtg ttttttgaaa tcggcctccc caaagcttct 2694961 tcatgcttta atctgctcct tctttttcac gatgctgttc acttttgtcg gaagtcccca 2695021 aagctcgata aatccgattg ctgcatggtg atcaaatgca tcgtcttttg tatatgttgc 2695081 aagtttttca tcatatagag agtattccga tttacgtcct tctacaattg catggccttt 2695141 aaacagcttc acgcggacaa tgcctgtgac atgcttttgc gtttctttta agaaagcgtg 2695201 cagcgcgtct tttaacggtg agaaccataa gccgttgtaa atgatttctg acattttttg 2695261 ctcgatgatc ggtttaaagt gggctacctc tttcaccagt gtcaaatctt ctaattcttt 2695321 atgcgctttg atcagtgtca tcgcaccagg gcattcgtat acttcccggg atttaatgcc 2695381 gacgaggcgg ttttccacgt ggtcgatacg tccgacaccg tgcgcgcccg ccatttcatt 2695441 cagcttcaag atcagctcag aaagcgagta ggaaacaccg tcaatggaga caggcacgcc 2695501 ctgttcaaat gcaatttcaa tcacttccgg cgtgtccggc gttttttcca gcggagctgt 2695561 taaatcgtat gcaccttctg gcggcgccgc ccatggatct tctaaaatgc cgcactcatt 2695621 ggcgcgtccc cagaggtttt ggtcgataga atacgggctg tcaagattga tcggaatcgg 2695681 aatgccgcgg ctagccgcat attcaatttc ttcttcacgt gaccactgcc attcgcgaac 2695741 cggcgcgatg acttctaggt cagggtttaa tgatttaatg gagacttcga aacgaacctg 2695801 gtcatttcct ttccctgtgc atccgtgggc aatcgcctgt gcatcttctt tttccgcaat 2695861 ttcaaccagt tttttcgcga tcagcggtcg agataatgcc gaaacaagcg ggtattttcc 2695921 ttcatacatt gtgtgggcct gcaaagagat aagcgcgtaa tcctgtgcaa attcttcttt 2695981 tgcatcgatc acgtaggagt ttgtcgcgcc gacttcaagc gctttctgct gaacaaatgc 2696041 caaatctttg ccctcaccga catccaggca gcaggcgatt acattatatc cttgctcctg 2696101 aagccatttt attgcgacgg aagtatcaag acctcctgag tatgctaata cgactttttt 2696161 ctgttctgac atgataaaaa tcccctctca accgtgtttc tattttgtat aaaaataaat 2696221 tatatttaat aaaaatacat tttgtatgta tacactttaa caagtacgtt tcgttttttc 2696281 aagcctttta taaaaaaaac ttcacctaaa tttcaggtga agtttcatag tatttattca 2696341 tttacttgtc ttttctgatt tctctgacca catgcgcaag ttcgggaata atcagcttat 2696401 tcattgccag ctttactgcg ccgcttgagc ctggcgttga gaaaacagcg gtatgctgaa 2696461 tgacgccggc agttgctctc gacatgattg cggcagagcc gatatcctct gtataactca 2696521 gcatcctgaa tatttctcca aagccgggca gttctttcga aaacagcggc gttatggctt 2696581 caattgtgac atcccgatct gctatgcctg tccctccgtt taagagtacc gcgtctgtct 2696641 gttcatccat gcagcccgca agcactgacc gttgcaaagc atccttttcg tcttttacaa 2696701 tttcatatgc ggcaatatga tgaccggctt cttctaaaaa tgagatcatc agcttgccgc 2696761 ttttatcggt ttcatctgtc ctcgtgtcac tgacagtaat cactttgcac cgaacgatat 2696821 cgggagcttc ttgtttatgc tcttgaacgc tcattggccc acctctttta tgttttctgt 2696881 ctgtcactat catgcatcaa caaaaaagca cattcaagag aatgtgcttt catgcgattt 2696941 attttgctaa acgaacaacg tcgcgcgcaa tcatgacttc ttcatcagtc gggatgatca 2697001 tgacttttac tggagaatgc ggatagctga tgaaagcttc ctcgccgcgc acgttattaa 2697061 gcgcagggtc ccagtatacg cccatgaatt ctaaaccgcg aagaacgcgt tctctgactt 2697121 ccacactgtt ttcaccgata ccggcagtaa agatgatcgc atctacaccg ctcattcttg 2697181 cagcgtaaga accgatgtat ttgtggattc tgcttgcgaa tacttcaaga gccgtttccg 2697241 cgcgctcatt tccttctttc gtagcttcaa cgatgtcacg aagatcgctt gagaaaccgg 2697301 aaatgccgag cagtccgctt tttttgttta atgtattcag tacttcgtca gccgtttggc 2697361 ctgttttctc catgatgtat gggatcaggg cagggtcgat gtttccagag cgtgtgccca 2697421 ttgctacacc ggcaagcggc gtaaagccca tggatgtgtc aatagatttt ccgccttcaa 2697481 cagcggcaat acttgctccg tttccaaggt ggcaggaaat caggcgcaag tcttttaacg 2697541 gacggccgag aagctctgcc gcacgctcag ttacatattt atgtgaagtg ccgtggaagc 2697601 cgtatttacg gatgccgaat ttttcatagt attcatacgg caagctgtaa aggtaagact 2697661 gctcaggcat tgtttggtgg aatgctgtat caaatacagc taccgcagga acatttggaa 2697721 gcacttcttt gaacgcttta attccaacga tatttgccgg attgtgaagc ggtgccaatt 2697781 cagaaatatc ttcgatttcc ttaatggttt catccgttaa taaaacagaa tcgctgaatt 2697841 tttctccgcc gtgaacgaca cgatggccaa ttccgtcaat ttcattcaag tctttaataa 2697901 tgccgaattc cgttaactta ttcagcagca ttttaacagc taccgcatga tctggaatat 2697961 cagttacttc tgtatttttt tcgccgttca cagaaattgt gaatacgctg tcggcgatac 2698021 cgattcgttc aactaaaccc ttcgttaaaa cggtttctga aggcatttcg aaaagctgaa 2698081 atttcaaaga cgagcttcct gcgttaattg caataatttt ggacatgatt gacgctcctt 2698141 tatactctgt atcaacaact tcgtttttcg tacttttttc ccggtgaata tcaacatctt 2698201 ctccgaaaaa tatctgactt ttccatttaa acattgtcat gtcggctttt caagtcaact 2698261 tgcgtattga taacgcttac aataagaagt cgttattttc agacacattc actataggtt 2698321 ttgtattgat gaacgcttac aatttgcggt ttttccctct gtattttgtg tttcaaagct 2698381 ggattcaatt cgtcaagtcc ggtcttcaaa agcataaata aaagcagctt aggcatcgac 2698441 ctcatacggc tgtctaagct gcttttaaaa cacttacttt tcttttttaa accattcatc 2698501 aaattgagcc atcatatcaa gcatcgcctt ttgattggag aaagacggaa gattcgcaag 2698561 cagaatttgc cccggcgctt tcgtattctc tccttgtttc tgaagcacaa ggatgctttt 2698621 ggcatgagct tcgtctttaa aaatagattt tggcagctgc aacagtgcgt tgatatgaac 2698681 cttatctttg aaaaactgtt tcagcttgcc gctttgggag ctctcaaaca aatgattcgg 2698741 aatcataaaa aataagtagc cgcccggttt ggtatgcttg acgctctgtt caataaacag 2698801 atgatgagcg aaggaatggc cttcgtcagc tttgagctca aacgcttctg ctccttcgtc 2698861 attcggataa tagccgactg gcagatcaca aatgaccgtg tcaactggat cgataaacaa 2698921 cggctcaagg ctgtcctggt ggaaaagctc aagctctttt ttcagaaggt tcgcttgggc 2698981 ataggcgatc ttcaagagca catcatcaat ttcaatgcca aagctgtttg ccgttttttc 2699041 agacagctgg ttcagcacgg taaacagaag gttcccagtt cccagggctg gatcaagaat 2699101 ggtcagttcc tttttgtccg ccataaattt attcaccaaa tagctgatga aaagcccgat 2699161 cgtatccggc gtcatttgtc tgtttggatg cgagatatct ttcattcctt taaggacggc 2699221 aagctgaaaa gccttgcgta cccactcatg ctcatacgtg ccgaattccg ctttttcaag 2699281 cagagcctga agttgtttgg ttttctgatc agcaggcagt ttcagctgat ccgttttttc 2699341 aagaaaatac atttctcctg cttcggccag cgcctctata tatgaaatct gcaattcatt 2699401 ctttatcata atcgcggctt cgtttaacag ctcatacacc gcacctacat ggtctttttg 2699461 catattgtgt tcctccttgc catgaaaaaa gctccggcgg cagcctggag cttttttccc 2699521 tgcttacttt actaatgcct tagcagcctc aattggcttt tcatagttcg ggtggtttgt 2699581 tgcttcgctt acatattcag cgtaaacgac ttttccgttc tcatcaagga caaatacgga 2699641 acgcgcaagc agacgaagtt ctttaatata cacaccgaac gcttcgccaa atgacatatc 2699701 tctgtggtca gacagtgttt ccactttgtc aattccgtta gcgccgcacc agcgcgcttg 2699761 cgcgaatgga aggtctgcac tgattgtgta gacgttgaca tctccaagct ttgcagcttc 2699821 ttcgttaaaa cggcgtgttt gtgcatcaca aacacctgta tcaattgaag ggataacaga 2699881 aataatcgtt acctttcctt tcatgtcagc taacgatttt tcttcaaggc tgttagtcag 2699941 cactgtgaaa tcaggagctt gatctcctac cttcacttct tgtccgacaa gtgtaaccgg 2700001 accgcctttg aatgtaattt cagccattat aattcctccc ttttgtatgt atgtctctat 2700061 catagtaaag tttcctgcaa actgcaaagt ttatgccaaa aaaaagttaa ctgcggccag 2700121 cgcagttaac ctttttttaa taattcatat tgttcatttg gttttgattt tggccttggc 2700181 tttggttttt gttatttttc ttgaacattt gctggatgcg ctcgagtgtt tgaggggctg 2700241 cgtctaaaat tttctctatt aaatgggtat tttcatctaa atgaagcatt ctgatgcctg 2700301 tcgatccgac aattaaaaac gcgatcggcg taatggacac accgcccccg cttccgcctc 2700361 cgaaaggaag tttctgttct cttgtctcat cgtcttccga tttcttttcg gccggctttc 2700421 cgccaaactc gcttccgcct gcggcgaatc cgaatccaac tttagaaaca gttaaaatca 2700481 cacttccatc aggcgtttcc actggatctc cgatgatggt gttaacatca atcatttcct 2700541 tcaagttttc cattgcggtt ttcattaaac cttggatggg atggtctgcc atatacgctt 2700601 cctccttaaa ctgatgaatc attctttgaa gtcattctag ccgacggatt cttctttaat 2700661 acggatagct cccgtccgta tttgacgaat ttgaaagctg caagcatagc atgtccaaag 2700721 cgaaaaaaga atatacactg aaaatgggtc ttggaaacag ggacttgaaa cgacgggatc 2700781 acctcataga caggtttatt cacaaagtcc aggtggtcgt agagcattgc tgcgataccg 2700841 cccttcacgc cccatacagc accggttaac acacctgtca ctgccgcgtc ctgaattccg 2700901 attactgtaa cccattctag ttttgtgata tgtaaatgcg cgagaaaaga cgcgctgatt 2700961 ttccgcagtc tggtgacctg atgcaaaagc atttcgattt tattaatgct ttgctgcaca 2701021 tcgttttgtg taattttttt ctttccgctg ctttttttca ttttggattc agttttttgt 2701081 ttgatatcca ctgttccgtc ttctttgttc accttaatcg ccgggattgt ttttttgatc 2701141 cttataaggc caaacagcgc cgtaatcttc aaggtcaatt tgtcattatc atcggcatga 2701201 agatactcca gcgcgacatg gattttcatt ctgagaagca gtacgatccc tatgagaata 2701261 agaatggctg tcagtacata caccatattc ttcacttcct ctaggagcat tatcgccaat 2701321 tcctaaaaaa ataaacccgg acggaagtcc gggttatcgg ttatttgcgg tataattttt 2701381 catgcaccac ggtggtatcc gcgatgtaat catgaatccc ttgttttgta ggtgaaaagg 2701441 caacaacgat atataaaatc caaatcttat caatataccg tccaaccact tcacgaaaaa 2701501 tcactgtact ccatgtcagc ttgctatctt gcttcacaga aaccactttg aggccgaaca 2701561 ccattttacc aagcgtctgc ctgaagtatt ttgtcatgag tgcgaaatag gcaagataca 2701621 caataagcgt tgtcacactg taggccgaga aggtaaacat gccggatgtt ttcggcagat 2701681 ccaatacggt aaagagggga gaaacgagca aatggtttaa tccccatatc acgagccaat 2701741 caagcaggaa agcccagaaa cgaacccaaa agccagcata ggcatgtgtc agcagctccg 2701801 cttcttgcgg gcctttgatg tcattgcgct ctaactcttc atatgtcgcg tccattattg 2701861 ttccctccta cttcgcatag agatacatca ttctcggcga accggattgc gatagaattt 2701921 ctctcatatt caaaaaatca atttcacttt taaacatttt gttcgcgccc atggaaaaca 2701981 gtgagcctaa tccgaagctt tcctcataag aaatgacaga ggcgtttttc aaatccttgt 2702041 gatccttttt catggccgta atggtatcgt cataaaaacc aagctcatca acgaggttca 2702101 gttttttcgc ctgccgtccg tcatacacgc ggccgtccgc aattttcttt acctctgctt 2702161 tcggcatgcc gcgccctttt gaaatgacat caacaaagcc ttcatacgaa ttatcaacca 2702221 tcgattgcat gatgtttttt tcttctttcg tcatctcacg ggaaggagac ataatgtcct 2702281 tatgggcccc gctcttaatc gtttcaaaag aaatgccaag cttgtcggca agctttgaat 2702341 aattgacgct ttccataatg acgccgagtg acccggtcag ggtttccggt gtcgcaaaaa 2702401 tcttatcagc cgctgttgag atgtaatagc ctcctgatgc tgccatcgaa cccattgaca 2702461 cgtaaatcgg ttttttcgtt tctttcttga tttcttccag tttcttatgt atttcagcac 2702521 tttcatacac tccgccaccc ggagaattca ccttcagaac gatacctttg accgtcttgt 2702581 catcttttgc gcgctcaagg ttttttaaga acgttctgtg gttatatccg tctgcaccaa 2702641 gcagactgct tgagtcccca ttatcctgaa tggtgccgct gacctctaat acggcaattt 2702701 tacttgaggg actgccgttt tccagcgtct tctcctgcga ttcatccgtc agtgatgtga 2702761 gatccgtttg agcgcctttg acgctttcaa agaaactcat agagatgctg acgataatag 2702821 acacgccgaa aatccccaga gcaatcacta atgcaatcca tctttttgca ttcatttttt 2702881 ctcctccttt ttcctaaact ctctcattat acgattcaat atgaaaaatg tttcacttca 2702941 tgagaaagct ccggcttaac gggctgccgg caaacgtggt acacttatgg ccaaaggtat 2703001 tttatcacaa atactggatg gcagaaaaac ttaaatatga cagcaaaggg gaaatgggat 2703061 atgaccgatc aacgccgtaa tgtttatttt tttcacaaac aggatcagga aacgaacgaa 2703121 caagcccgct cgttaacaca attagcggaa gagcatggat ttaccgttgt gaaccagcac 2703181 tcagacgcca atattatcgc tagcattggc ggggacggca catttttgca ggcagtcaga 2703241 aagacgaatt ttcgtgacga ctgcttgtac gtcggcatta ccaaaaaggg gaaagctcat 2703301 ttatattgcg actttcatag tgatgagcga gaaaaaatgg tcgatgcaat gacgtttgaa 2703361 caaattgaag tgagaaaata cccgctgatt gaagtgacag tggatcaagc cagtcctttt 2703421 cactgcttaa acgaggtatc catccgctca agcatcatca aaacctttgt gatggacgtg 2703481 ctgattgacg atctgcactt tgaaacgttt agaggtgacg gaatgattat ctcaacgcct 2703541 acagggagca ccgcctataa caagtctgtt gcaggagctg ttgttgatcc attgcttcca 2703601 tgcatgcagg tatcagagct tgcatccctt aacaataata cctaccggac actcggctcg 2703661 ccatttgtcc tcagctctga ccgaaagctg acccttcgtg tggtgcagga cggcaacgaa 2703721 cacccaatca tcggcttgga caatgaagca ctcagcacga gaaatgtgaa aacgatcgaa 2703781 atcaaactgt ctaataagaa aatcaaaaca gtcaaactaa aggacaattc attttgggaa 2703841 aaagtgaagc gtactttttt atagaaaata aaaggacagg ctgctgcctg tccttttatg 2703901 atttctcata tacaatctgg ccgttaatca cggttttttt aatctctaaa agatgaagct 2703961 gtgcggggtc aatggcaaac ggatcaccac tgagaactgt aaaatccgcg tcatagcctt 2704021 ccgcaatttt tccgcgtgac ttctctttat aaatgatacc ggcgctacct tctgtataaa 2704081 gctttatcgc ttcatataca ggtaaacatt cactttcatt atagcttggc ccgttttgct 2704141 catgactgct tttccggagg accgcggact ggatccctag aagcgggtca acaggctcaa 2704201 tcggggcgtc tgaaccgccc gcgcataaaa tgcctttaga tatgagggtt ttccaggcaa 2704261 atgcagtctt catccggtct tttccgagac ggtcaatgac ccacggaaag tcgcttgcaa 2704321 cgaagtgcgg ctgaaggtca agtgcgatcg gcatgcgtgc tgctctctcg attaattcgt 2704381 tatcaagcac ttgagcatga ataagccgat catgccggcc gtttttgggc ggatgctttt 2704441 ctattgcgtt cagcactttt tcaaaagcaa gatcgccgat tgcatgaaca gcaacctcca 2704501 tccctttttc tctcgctttg cgaatgagcc ggccaagggt ttcgtcatcg tgaacctgaa 2704561 caccatttgt tgatggatca tcctgatatg gttctttcaa taaagccgtt ctcccgccaa 2704621 gcgccccgtc cgcaaagatt ttcatagcac cgaactccac atacgggccg gacagcttct 2704681 ccagctgctc ccatcgatcg acagcttcat gatgaacgag caaatggcag cgaaacggat 2704741 actttccgcc agcggcagct ttctcataag ctttcatcgg caccgaaaca tcaccataat 2704801 aggacaagtc ttccgaatga ccgcccgtca ggccttttgt ccagcaatcc tttattgcag 2704861 ccgttaatgc ctcatcaaca tagtgctggg agactggcgg gacagccttc agaatcaaat 2704921 cctgcgcctt atcaaacagg agtccggtcg gctcgccatt tgcatctttt acgatgactc 2704981 cgccgtcagg atcaggagta tttcttgaaa ttcccgctgc ttgaagagcc gcagaattga 2705041 cagctattgc atgccggcat atacgcttga gcaagacggg cctgtcagga aacaggcgat 2705101 caagatcatg cttagtcaag tagtcaggtg tctcaaactg attttcattc cagccttctc 2705161 caatgagcca atcgttttta ggaagctgcc gctctctttc cttcgcagcc tgtaaaattg 2705221 aatctttcga cgtcagtgcg gacagatcga gctgaagctg tttctcaccg tggccgatca 2705281 aatgtagatg gctgtcaaca aaaccgggga acatcactgc tccgttcagg ctgatttctt 2705341 ctgtttccgg cgacccgtac ttttccttca aacgttcata gctgccggtg ccttttataa 2705401 caccatcctc aacataaact gcctcagtcc gatcgccttc ttcgagcatc gtataaatga 2705461 aaccgccgtg ccatatcgcc ttcattcacg ttcactctct ttctttacgc ctttttattg 2705521 gctttgagct gttcttcacg ttttcttaat tccactcgtc tgatttttgc agaagccgtt 2705581 ttcggcaggc tttccacaaa ttcaatttct ctaggatatt tgtatggagc ggtaatcgtc 2705641 ttcacatggt tttgcagcat tttgacaagc tcatcactgc gtttttcatg attttgcagg 2705701 acaacatatg cctttacgat ggagcctctg atttcatcag ggcttgcgac aacagcacat 2705761 tcttttactt ctgggtgctt aacaagcgcg tcttccacct cgaaaggccc gatcgtatag 2705821 ccggagctga taataatatc gtcatttcgg ctttcaaacc agaagtaacc ttcctcatct 2705881 tttcttgctc tgtctcccgt taggaaataa tcgccgcgaa tttgtgtttt cattctttcc 2705941 ggatctttaa aatactcttt aaagagcgca ggcgtactga ggtgaacagc gatatcgcca 2706001 acctcaccag gtttgcagat ttcaccgtct tcatttatga tctccacctg atttcccggt 2706061 gtcggttttc ccatgcttcc cggtttaata ggcgtatctt tcaaaacacc aaccaaaagc 2706121 gtgctttctg tttggccata tccgtcccgt accttaatgc caaagtgctt ttggaaaaca 2706181 tcaatgactt cacggttgag cggctcacct gcggaaacag cgctgtgcag ggcagaaaga 2706241 tcaaagcgtt tcaagccttc aaccttcgcc attaagcggt attctgtcgg agtgcagcag 2706301 aaaacattga ttttgtagcg atttaaaagc tctagatatt tttctgcttt gaatctgccg 2706361 tggtacacaa aaccggttgc tccgctgcca agcaccgcta aaaacggact ccatacccac 2706421 ttttgccagc caggggcagc agttgcccag acgatatcct tttcagaaat gtcaagccaa 2706481 gcgccggcag aagtttttaa atgagcaaat gcccatccat gtgtatgtac aacacctttc 2706541 ggctgacctg ttgtcccgga tgtataagat aagaaagcca tatcatctct tgttgtgtca 2706601 gctgttttaa attggcttcc gtccgcttca attgataaga ggtttttcca gccggcatca 2706661 ttttcaccaa tagacagtgt aatcagtttg tcagccgtac tgacatcccg gaaagcgcca 2706721 ataaattcgg agtagacgat agcgcctttt acctctgcat gttcaatccg gtattcaaga 2706781 tctttcgcgc gaagcatttc ggagcacgga atgacaacca ttcctgattt caggatagcc 2706841 aaataaacag cataggcttc aagcacccgc ggaaccatta caatcagctt gtctcccttt 2706901 ttaaatccaa gatcagctaa ggccgctccg attttatttg tttcttccat cagcttttca 2706961 tacgaccaag attcttgctt gcccgactcg tcctcccaaa gaagagcggt tttttgtcca 2707021 gcagcactga acttttccat ttcattcact aaattatatt gcacaggggc aattaaatct 2707081 tcacgtttta acacgaacaa ctcctcactt tctccaccca ttatacataa atacaggctc 2707141 tttccgtaag gatatgccta aaagcaacct ctgtaaacat agattttata ggccgctggt 2707201 ccttttttat atgtaaaaaa tgaaaaagag tggggatacc cccactccta agccattatg 2707261 tgaaattgta aattagaatt gtcctccgcc catgttttgt tgagcaaaag atacaagacg 2707321 ttttgtgatc tctcctccaa cagaaccgtt agcgcgagaa gttgtgtctg ctccaaggtt 2707381 tacaccgaat tcagaagcga tttctaattt catttggtcg atcgcttgag cagctcctgg 2707441 tactaaaagg ttgttgctgt tacctgagtt attgttagcc atgtgtctca cctccttgtg 2707501 agtatagaat gtgtcaaaac acatggcttc attcagaaaa actttggtaa ttgtatacag 2707561 gagctgaaaa ttgatttaaa agagttcagc gaatttatcg ttagcttctt gttcgctata 2707621 aagggtcatt gtctcaatgt tatctaccgc ttcttgaata tacggctcga aatcaacaaa 2707681 gctttcaaag tgttcaattt tctctttttt agggcgtgtt ttcgggcttg gcggtgtaaa 2707741 gatcgtgcag cagtcttcaa acggctgaat acttgtctca tatgtgccaa tttcccgtga 2707801 tttttcgatg atttctgttt tgtccatggc gattagcgga cgcaaaatcg gtgttgacgt 2707861 caccgcatta attgcataca tgctttcaag cgtttggctc gctacctgac cgaggctttc 2707921 tcccgtaata atggcaagcc cgtttctctt ttctctgatt ctgtcggcta tctgaagcat 2707981 gaggcggcgg gttgccgtca ttgtgtaatt ttcaggaatt tgtttttgga tgagctcttg 2708041 cgtttttgta aatggaacaa tatgaagtgt catgcttccc ccaaaacggg acagacattt 2708101 cgccagatcc attacctttt gctttgcgcg ctcgcttgtg tatggcgggc tgaagaaatg 2708161 aacagcttct accgacaatc cccgtttcat cgcataaaaa ccggccacag ggctgtcaaa 2708221 accgccagaa agcatcagca tcgcttttcc tgctgaacca actggcagcc cgcctgcacc 2708281 tttttcatca cgaattgtca aaaatgttgc ttcttccctg atttcgattc tgagcgggat 2708341 gtctgggttg cgaacatcga ccgtcaatcc ttctgtattt cgcaaaatat ggccgccgat 2708401 ttcagcgttc atctggtttg tatctaattc aaattgctta tacgctctct ttgtcgcgac 2708461 tttaaacgta tcacctggtt tatactgatc tttgatagcc tttagtgcgg ttgccttaat 2708521 atcatcaagg cggctgtcac acttaattgc caggctgaag ctttgaatcc caaacacttg 2708581 ctttaaatga ggaaaaagag cctcaggatc ctctccattt aatgtaatcg tcatacgatc 2708641 cctgttggaa aagtatttta aattcggata gtctttcaaa acgagtctga tgttttgttt 2708701 taagcgctca ataaagcttt ttctgttttt gcctttggtc gaaatttccc caaaacgaat 2708761 taatatatga tcgtaattca tgttctacct catcatttcc cttaattttt tgatgccagg 2708821 acgaagcgcg ttcataaacg gttctgccac atcgcttgtc tggctgtaat ttaaactgat 2708881 tctgatgctg cttccggcaa tctgctctcc tttgcccatc tctaagagaa ccttgctggg 2708941 cttatgttct tttgccgagc aagccgatgt tgtggagacg aatatatcct gttcctcaag 2709001 catgtgtaaa agcacttccg ctttaatccc cggtacagag aaattaataa tgtgcggcgc 2709061 gctattcatt tgaggcgtgt tgataacgac gccctcaatt tcactcagcc tattcataaa 2709121 caattccttt acggcagtca tcgtgtcaag ccgtgtgtca aaatcagcag aggccagatt 2709181 aatggccttg gcaagcgaaa ccgcaccagc agtatgttct gttccggccc gtatgccttt 2709241 ttgctgagag cctcccgtta tgagcggaat aaggcgtgtt ccttctttta caataagtgc 2709301 gcctgtcccc tttaggccgt gaaatttatg ccccgaaatt gaacatagat caatgccggc 2709361 cttttcaatt gccaagggca ctttatagat gccctgcaca taatcgacgt gaaacaaaat 2709421 gttcgaatgc tctttcagca cttctcctgc cgcttcaatc ggctgcacgg aaccgacttc 2709481 attgttcaca tgcatcatgc tgacaagcac ggtatcggga cggatggctg cttttagatc 2709541 ttcaatagaa acaaatccgt cttcattcac agaaagataa gtgatatcaa acccgaacaa 2709601 ctctttcagc tgttctaacg attccgtaac ggatggatgt tcaatagaag tggcaatgat 2709661 atgtttgcct gtttttatct ttgacaaagc cgctcctttt aaagccgcat tattggcttc 2709721 tgtggcgcct gacgtaaata caatatcata tttttttagg cctaaggacc ttttgatttg 2709781 atttttggct gcttgaagca gctgttccgt ttcggctcca tatcggtgca aagatgaagg 2709841 attgccaaag tatcggctgc tcgtctgttc atatacgttc aagacttcat cgtaaggctt 2709901 cgtcgttgaa ctattatcta aatatatcat cttttttact cctttatgaa agcggtacaa 2709961 ggtatgatat ttatgttacc ataacaaaat ttaatagaaa attacgaaaa actagtattg 2710021 acttctaatt tttttaccat ataataagat ttgttcgttt cgtcatatta tctgacaatt 2710081 aattgacaga atattttaac ataattatta ggaggatttt tttcatgaaa cactcactgc 2710141 ctgtcaaaga taccattatt attggtttca tgctatttgc gttattcttt ggagcaggaa 2710201 atatgattta tccgccggaa cttggacaag cagccggaca caacgtctgg aaggccatcg 2710261 gcggattttt actgacaggg gtaggcctgc cgcttctcgg cattatcgcc atcgcattaa 2710321 ccggtaagga cgctaaaggc cttgctgaca aagcgcaccc tgttttcggc acaatcttta 2710381 ctgtcgtgct ttatttatca atcggaccat tattcgccat cccgagaaca ggaactgttt 2710441 catatgaaat tggcgctgtt ccgtttttga ctggtgtacc agaaagactt tctttattaa 2710501 tatttacact tatctttttc ggcgttacgt actatttagc gttaaaccca tctaaggttg 2710561 tggatcgagt cggaaaaatt ctgactccca tcaaattcac aattatttta atcattgttc 2710621 tcaaagccat cttcacgccg atgggcggat tgggcgccgt gacagaagca tataaaggaa 2710681 caccggtttt taaaggattt ttagaaggct ataaaacaat ggacgcactt gcttcaattg 2710741 tatttggcgt tgtcgttgta aatgctgtaa aaagcaaagg cgttacacag tctaaagctc 2710801 ttgctgcagc ctgcattaaa gcaggtgtga ttgccgcttt aggcctgact ttcatttatg 2710861 tatcccttgc ttatttaggt gcaacaagca caaatgccat tggtcctgtt ggtgaaggag 2710921 ctaaaatttt atctgcgtct tcccattatt tattcggttc attgggcaac atcgtactcg 2710981 gagcagcgat tacagtcgca tgtttaacaa caagcatcgg ccttgtcaca tcttgcggcc 2711041 aatatttttc aaaacttatt ccggcattat catataaaat tgtcgttacg attgtcacgt 2711101 tattcagctt gatcattgcg aatttcggac tcgcgcaaat tatcgcgttt tctgttccta 2711161 ttttatcagc tatctatccg cttgccattg tcattatcgt tctttccttc atcgataaga 2711221 tctttaaaga aagacgcgaa gtgtacatcg catgcttgat cggtacagga cttttcagta 2711281 ttttagacgg tatcaaagca gccggttttt cacttggatc tttagatgtg tttctaaatg 2711341 cgaatcttcc tctttacagc ctcggcatcg gctgggtgct tccaggaatc gtcggagcgg 2711401 ttatcggcta tgtgctgacc ttattcatcg gaccatccaa acagcttaat gaaataagtt 2711461 aatgtcacag aacgcctgcg ttattgcgca ggcgttttgt aataaaaaaa gagcctgctc 2711521 attacactgc gggctctttt tcatggtcgt gattatctaa gcggatatgt cagctttgat 2711581 tttttcaact gcacctggcg cagccttttc tacagcggca gcggcaattt cataagagtc 2711641 gtcataatca aaagcataaa aacgtctttc cgcttctttc agctgttcag ataaaatatg 2711701 attctggctt ctgaaccggt ttccgaactg aatgattttt tcaatgagga tgacctgctc 2711761 gacaagttcc tctgattccc ggcttgccct gttgacgata tcttctgctt gtttcaaatg 2711821 ggctccggct tcttccatat ttaatggaag ttcgtttagt tgattgaccg tttcttgaat 2711881 atgatgatgc gcgttctcca gcatctcttg aatatggctc ggaatgcctg gaatgttgct 2711941 agtcttcagc agtcttgctg tctcagaaat tgtttttttc aaattgctga gcgtctccct 2712001 cgcctgaagc tcttcttttc tcagcgcttg cagattttca cgatactcgg catgctcttt 2712061 tttcacttct tcaatttgct tctctattga agcaacttct tctactaaaa gtgagtaggc 2712121 gacatgctct gcatcaagct tatctttaac ggatgatagc agctttccaa tttcatcaag 2712181 gcgcttttca aaagcctgct gtttgccgag ctcaccggct gtcagcctgt agctttcctt 2712241 caccagctca gtttccgctt tcgtatgctc tttctcttct ttaagcttgt cgtaagcaat 2712301 aatcaattca ggcattttgc ttagtacgga ttgaccggct tcaacttcgc cctccagctg 2712361 ctgataaaca gattgaatat tttcgtcaat gagctgcagg attgcggacg cttcatcaat 2712421 atccagttca gtcatcagga catgttccgc tcgtttcagc tggtttgaca gattttctaa 2712481 ttccttatca agctggatat gctcaagctt gtaccctttt tctttcattt cgccatagcc 2712541 atccttgagc tttgcaatct gtccgggcac cgtctgttta cagtcagcta acagcttcgg 2712601 cacatcatct atgtatgact gaagccgttc aagattgcgg tcctgctcaa gcagtacttt 2712661 tcgtgcagta atatagtttc cgccttctgt ttcttcttca aattgtttga tgccgctcca 2712721 aatttcgtcc agatcctttt caaggctgtc ataaagctcc ccgtaaaggt ggctgtaagc 2712781 cagcaggttt tttcgagatt tcgaatagcg ctccctcacc tgttcaatct cttcacggct 2712841 cttttcctca cttgtgacaa gatcgctgat ttcccgaaga atcttttcaa tgcttgattc 2712901 agccgctgtc agcaggtcgt cgatatgaac gagcacttga ttggcctttt taaaccggta 2712961 tttgtctgca ttttcctcgg catcataaag gagctcttca actttcggca tgtgggctgt 2713021 gacaatctca tcccattctt cacgccactt ctcaaagaac tcttctgtct gacccgtcat 2713081 ttttaaatgt tttattttag acatttcttc cacgatcgac cgattcagaa tttcaatctt 2713141 ccacgattcc agccggtcga tttcggcgta gatttttttc ctgaaaaagt agcctgccgc 2713201 aaacagcgca agcagtacaa ttaataatcc aatgacaaac tccataatga gcccccttgc 2713261 tgtttacctt aatctgtcag ggtgttttat ttattcagaa agatttcagg atatgtattg 2713321 agaaaaactg tcgttttcat tgttattatg ataccatgta acaaacattt tttgaccaga 2713381 aatcaaaaac tttttgtgca aaatcggcag gatttgacta ttttttcatg gggtgacatc 2713441 aatgcaaaag cgagacggac atattcacac accattttgc cctcacggct ccaatgacac 2713501 actcagacaa tatgcagaag aagccttaaa aaaagggttc gaatcgatta cttttaccga 2713561 acacgcccca ttgccgccat cttttaccga tcccacgccg ctgaaagaca gcgcgatggc 2713621 gcaagcttct ttggaacgct atattcatga aatttccgga ttaaaaaaag aatatcgcgg 2713681 acagcttagc atacggacag ggcttgaagt cgattatatc gctgaatttg aagacgaaat 2713741 tacattattc ctagacacat acgggccata tttagatgac agcatcttat ccgttcattt 2713801 tttgcgcaca gactcttcct atctatgcct tgattatgac gagcatacct tcaaagagct 2713861 gatttcagcc tgcggaagca ttgaagcggt atatgaacaa tattaccgga gtatctattc 2713921 ttccattgta gcatctctcg gcgtttataa gccaaaaaga gtcggtcaca tcacactcgt 2713981 ccaaaaattc atcaagctgt ttccatacag catgtcagag catattcgcg gcctcgtttc 2714041 tctgtgcctg aatgccattg aagaaaacgg aatggagctc gacttcaata cttccggctt 2714101 aagaaaaact tacgctggcg gtatttatat cgaggattgg atgctgaatg aagcgaagca 2714161 aaagaagatc ccgcttgtgt ttgggtctga tgcccatcaa gcgggagatg tcggatatgc 2714221 gtatgaggcg tttttggaac ggtgctagtt ggtgagcgcc acgtctcctg tccggaagac 2714281 gcttctgatc caaatcttga tttcttcaaa atacatttta taaaaatacg gctcgtgcgg 2714341 ctgcatgtag agtacttctg aaatatattg aggctggaga tagggcatca tcaagagaga 2714401 ttttaattgg agaataaaat gaggcagcgg cagcgttaaa tattcacgct gtttttctcc 2714461 ttcctcaatg atcagctgga agatatactt ttccttcatt agatatgtcg acataatttc 2714521 cctgattaat gtggagtcaa ttgtgacttc ccggtagaca aaacgagtta attgacgatg 2714581 attatgctga taggataaaa tatcgaaaac caattgaaga agctgttcct gcgtgctttg 2714641 agtagagata ttgcttgccg ctgtttcaag cgttttgctg tagccttcgt aaaactctga 2714701 aactaagtgt tccatcaagc ctcctttgcc tttaaaatag taggagatgt gcgcaacatt 2714761 tacatcagct gactttgcga tttcacggac agacgtgcca gaaaatcctt tttggttaaa 2714821 aagcatgaca gcagattcaa taattttgtc tttggtgctt actttcatac ggctcactcc 2714881 ttcctcttga tactattcaa gcagaaagcc gctgttcctg taagaactta tcgacaaatg 2714941 ccggcagaaa agccggaact ttgttttata ttatagaaaa agtgagggtt ttccatgttc 2715001 catgtcgaaa aacaatctgg agataaagaa aaagactatc agcttctgct aaaacagctc 2715061 gaagccatga ccgaagacga aacagaccaa atagctaact atgcaaatgc ctcagcactg 2715121 ctgtatcatt cgctgcctga agtcaactgg gcgggtttct attttgccaa agaagaggat 2715181 ggacagcttg tgttaggtcc gttccaaggc ctgccggcat gtgttcggat tcctttcggc 2715241 agaggggttt gcggcacagc gtacgcaaac ggaaaagtgg aacgtattga ggatgtaaac 2715301 gcgtttccgg gacatatcgc ctgcgatgca gcgtctcaat cagaaattgt gcttccgatt 2715361 cgtgtagacg gaaaaattgt cggcgtcttg gacatcgaca gcccagtgaa aaaccgtttc 2715421 gacgaaattg atgaaaaata cttaactcaa tttgccgaaa cgctagaaaa agcgttagcg 2715481 cagtaatata aaagcccaaa actgatatcg ttttgggctt tttttatttt attgagtcat 2715541 gaatcatcaa gcggtttttc ccgctccgtt tcgcgctgta gagcgcttca tctgcctcat 2715601 gcacaagctc tttcagcgac ttttttgttt ctgtcgtcca gcaggagata ccgcaggaaa 2715661 tggttacctc gggtttcgta ttttttctga ccgcgtaaac cagtcgctcg gtaatccgtt 2715721 tccccactgc aaccggcaca tttggcaaat aaatcgccag ctcctctcct ccccagcggg 2715781 caccgacatc atgctttcgg atgttgcttt taatcactga agcgacttga attaaaatct 2715841 cgtccccagt ctgatggccg tacgtatcat ttacattttt aaaattatca atatcaacaa 2715901 gaataaaaac acccttttga tggattttca tgctgtattg aattttttca tctaaatacg 2715961 ctcgtgaata cagttcagtc agctgatctg ttttcacgag atgctcaagg cggtcgcgaa 2716021 gcattgaatt ggttacagcc agtgtcgcgt gatgaatcag cgcctgaaac agcttgtaca 2716081 tttcaaatgt aaaagcgtac agctcctgtt tcaataaaac cgcaaagcct aaaagccggt 2716141 cgttttgaat catcggagca gccatcagcg agccgtaccc cgccttccca aaaacagact 2716201 ggccattccc gatgaaaacc cctttttcac cttcatacag cttttctttc agctcattat 2716261 aaaaatctga cggcttcgct tctttaaaaa atgctgtgct gcctgggagc aatgttaggt 2716321 tttcaaaatg gtctatatga aaaaatccca cttcttctgc ctgaaacgat tctgccattc 2716381 tcacagccag atcattcatt gtatcagtca atgtcagccg ctgattcagg cgtcgtgatg 2716441 tttcattaat caattccaaa tttgcgatgc ttgctttgga ttgttcgtag agctgggcat 2716501 tttcaaacgc ttttcccgcg gcgtttgcta acagcgacat ttcatcaagg caggcatcag 2716561 taagaaagct gtcacccgtt ccttcagcct tcaacacccc gtatgtgccc tgctgtcctt 2716621 tgatcggaat ataggcgaca gattcatttt tccgcaaaat gtctccggac aaatacactt 2716681 tgagcgcaaa ggaatcggat ttttcccctt ccatatacag ctcttttgca ggaatcccta 2716741 aacattggtc ttgatcgtgc gatataaata aagaaaactc aaaaagagaa aatgtgcttg 2716801 tcaagctttc taaaagctgc ttcagcacat ctgtctgatc aagcagtgaa tggaacagct 2716861 ctgtcatttt gtatatcttt ttttggtaga tcgttttgtt atagagtctt tcctgtttca 2716921 tcgactggtt taaaaatgaa gcaaccacgt ccggaagccc ttcaggaatc tcttcatcct 2716981 gcctgcacgc aagatggaaa cgcctgccgg agccgtcctc aatcagataa catgaagcgt 2717041 ttatttttga agcggaaaaa cgcgcttcac catctgccag ttttgtcaca aagtctgatg 2717101 gtgacggtgt aagcgaaaca caaagggttg aaaaataggt ttgaatagcc gaagtcagcc 2717161 atatgaaaga gtcggtgaat gtgacttttt cagatttggt taataaaaaa tcgagcatat 2717221 gataatgaaa ggcggataat tgatctttag tttgttctac catgttttta tcacctaaaa 2717281 gtttaccact aatttttgtt tattatatca taaacggtga agcaataatg gaggaatggt 2717341 tgacttcaaa acaaataaat tatataatga cctttgtgtg aaatattgca gcctttttgt 2717401 tcagcttcta tgttttcatt ttgttcctta tcaataaggt gtatcgtgta actctctgct 2717461 gctggagcga ggatacatga aaacaaaatg tgcatggtcg aatagagcag acggttttta 2717521 ttttccacaa aaataaaacc aaaggaggag tcacattatg gctcgctata caggtccatc 2717581 ttggaaactg tcccgccgtc taggaatctc tcttagcggt acaggaaaag aattagaaaa 2717641 acgcccttac gctccaggtc cacacggccc aggacaacgt aaaaaattat cagaatacgg 2717701 tttgcaattg caagaaaagc aaaagcttcg tcacatgtac ggtgtaaacg aacgtcaatt 2717761 ccgcactttg tttgacaaag ctggcaaact agctggtaaa cacggtgaaa acttcatgat 2717821 tcttttagat tctcgtcttg ataacgttgt gtacaagcta ggtttagcac gtactcgccg 2717881 tcaagctcgc caattggtta accacggtca cattcttgta gacggaagcc gcgttgacat 2717941 cccgtcttac ctagtgaaac ctggtcaaac aatcggtgtt cgcgaaaaat caagaaacct 2718001 ttctatcatc aaagaatctg ttgaagtgaa caacttcgtt cctgaatacc ttactttcga 2718061 cgctgaaaag cttgaaggta ctttcactcg tcttcctgag cgttctgaac ttgctccgga 2718121 aattaacgaa gcgcttatcg ttgagttcta ctctcgttaa tcgttttaaa aacccctgcc 2718181 gctatgcggt cggggttttt ttatcggctt tcgcctcttg ctggccaaca ctatcttgcg 2718241 cctgctgctc ccaatgatcc cgctgcagcc gttcttttgc aatcgtacac atgagattca 2718301 cgctttagcg ctcctttcat ttaaaaggtg gtgattggtc gtgtttgccc tatctaatat 2718361 actcttttcc tttcattcct atgcggtaaa caaaaagatc ctttgccttc agtggcaaag 2718421 gatctttttc ttatttatac gtcacaagga agtatttttt cttcccgcgg cgcagaacag 2718481 taaattggtt ttcgatgcgg tcttcacctg atagggtata atttatttcc gtctggcgtt 2718541 caccgttaat gtaaacagct ccgttttgga tgtcttcacg cgcttggcgt ttagaaggag 2718601 ataatttaga ttgcaccaac acatctacaa gtgaaagctc ttgggtgctg tcaacttcca 2718661 tagaaggaac atctttaaag cctactttta cgtcttgagc agaaagctct ttaatattgc 2718721 cgctgaacag cgcttgggag atgttgatgg cttgctccag cgcctcgcgt ccgtgaacaa 2718781 gtgatgtcac ttcttctgcc aggcgttttt gcgcttcacg tttttctggc gccgtttctg 2718841 ttttttcagc gtatgcttca atttcctctt ttgaaaggaa cgtgaagtat ttcaagtatt 2718901 tgacaacgtc acggtcgtct gtgttgatcc agaattgata gaattcatat ggcgatgttt 2718961 tttctttatc aagccagatc gcgccgcctt ccgtttttcc gaacttcgtg ccgtctgctt 2719021 ttgtgacaag cggaatcgtt aggccaaacg cttttgctcc ttcttcttct gattttctga 2719081 tcagttcaag acccgctgtg atgttgcccc actgatcgct tccgccgatt tgcagtttac 2719141 agtttttgtc tctgtaaaga tttaagaaat cataagattg aagaatcatg tagctgaatt 2719201 ccgtgtacga gatgccggat tcaattcttg agctgaccgt atcttttgcc agcatgtaat 2719261 tgatgccgaa atttttacca acgtcacgaa ggaaatcgat cacattcatt ttgccgatcc 2719321 agtcaaagtt gttcgcgatg acagctgggt tttctgctgc ttcaaaatct agaaatctgg 2719381 acagctggtt tttgattttt tgggaccatt cggatacgat gtcagcagtg tttaatgtac 2719441 gctctgcttt ttttccgctt ggatcaccga tgaggcccgt cgcgccgccc acaagcgcaa 2719501 tcggatgatg ccctgcaagc tgaaaacggc gaagtgttaa aataggcagc aggtgtccga 2719561 tatgcaagct gtctgctgta gggtcaaagc ctgagtacaa gcggattttt tcttcattca 2719621 gctgtttatt taacccttct tcatctgtca tttgctgaat caatccgcgg aaggataagt 2719681 cttcaagtaa gttagtcata agataaagct ccttttttaa ttaaaataaa aaacgcccct 2719741 tcgtttacac gaagggacga ttgattatcg cggtaccacc ctactaataa gagaatgcaa 2719801 acattcgtct tatcactttg cctgataacg gatcaggtcc gttctttcac tactgaaagc 2719861 ctggccggct ttgtttgcaa aagcggttca tgagtgtatt cgatatatcc gtctgtgctg 2719921 attttcaccg gccatcagct ctctggaacg taaggatatt ctacttgtct caatctttac 2719981 cttttcatat gaagctatat catttttaac ataaataaaa tcctgtgtca acgccgcctt 2720041 ttaatcctcc attgttgaca gatctccagc cggcagatta agctcccatg ccttcagcac 2720101 gcgcctcatg atctttccgc ttctggtttt cggaagctta tctttaaatt cgatctcacg 2720161 cggagccgca tgggctgcaa gaccctgctt tacaaatagg cggatctctt ctttcagttt 2720221 atcagacggc tcaaatcctt ccctgagtgc aataaaggct ttaatgattt ctccacgcac 2720281 cgggtcaggc tttccgataa cgcctgcttc tgcaatagcc ggatgttcga caagcttgct 2720341 ttccacttca aatgggccga cgcgctcacc ggaggtcatg atgacgtcat caactctgcc 2720401 ttggaaccaa aagtatccct cttcatccat gtaagcagaa tccccagaca cataccagcc 2720461 gcccggcatg aaatacgatt catacttttc agggttattc caaatggtat gcatcatgga 2720521 aggccagccc tttttgatgg cgagattgcc cattcggtac ggcggtagct cgttgccttg 2720581 attgtcaacg atcgctgcct ccactcctgg aatcggctta cccattgaac ccggtttaat 2720641 atccatgcaa ggatagttgc agatgagctg actgcccgtt tcggtcatcc accaggtatc 2720701 atggattcgt ttgttaaaaa ctttatgtcc ccatctgatg acttccggat ttagcggctc 2720761 accgacactg agcacatgcc ggagtgaagt tagatcatat ttcgcagcca tttcatctcc 2720821 cgctcccatc agcatccgaa aagctgtcgg cgcgctgtac cagacattga cgccaagctg 2720881 ttcaatcgtt ccataccagc tttccgggct gaaacgtccg ccgacgatga catttgtcgc 2720941 tccgttcagc cacggtgcaa aaatgccgta taccgtacct gtcacccagc ctggatcagc 2721001 cgtgcaccaa taaatgtctt cttcctttaa atcaaggacc cactttcctg tttgatattg 2721061 ctgaatcatc gcttcatgga catgcaacac gccctttggc gtaccagtgg aacctgatgt 2721121 atagtgaagc agaaagccgt cttttttatc catccattcg atatccaatc ttgtgctttc 2721181 ctgtttcgct gcttcatcat aattgatgat attcgtgccg ctctcagcct ctcccccgac 2721241 tacgaagaca tgctgcaagt gaggcagttt gtctaccggt attctctcca gcagctcagg 2721301 cgttgtgaca acaacctttg cctcactgtt ttcaagccgg tctttcaccg ctccctccat 2721361 aaatgcttcg aacagcggcc cggcgatggc gccaattttg attgcgccaa gcataataaa 2721421 ataaagctcg ggtgatctcg gcataaaaat aaaaacgcgg tccccttttt ccacatttcc 2721481 ataccgtctc agcacattcc cggctctgtt tgattcttcc ttcatttctt taaatgtgta 2721541 tttttcatcc ctttttgcgt ctttataata aagcgctact ttgttttttc gaaacgattc 2721601 ggcatggcgg tcaatcgctt catacgccgc attcagtttc cctgtctcat gccaagagaa 2721661 atgtttctct gcctcggccc aatcaaaatg ccggtacgtt tcttcatagt tttttaagtt 2721721 atgatccccc tctattgctg gtaacgcttt caagttcatg cccaaacatc cccctttgct 2721781 gaagttgtca caattattat agtatatatt catattcttc tcaattttta aaatataaac 2721841 catgttgaaa acgctttata atttggtatt cttaaagaag gcatgtattt ttgataagaa 2721901 ttgatgggac ggtgaattag tggaacatca taaaacatac cattcagcaa acatcaaaac 2721961 agcaaccggc tctttactga tagaagggcc tgtctctcca gaggatttgg caggttatga 2722021 gtttcataaa gatttaaccg catttcgccc gcctcgcgag cagcatgaag cgctagtcga 2722081 cattgcaggc cttcccgaag ggcgcattat tattgccaga gacggccgaa ccattgtcgg 2722141 ctatgtcacg tatttatatc ctgacccgct cgaaagatgg tctgaaggaa atatggagga 2722201 tttgattgag ctcggagcca tcgaagtagc gccggactat cggggatgcg ctgtcggaaa 2722261 gacgctcctg accgtcagca tgatggatga acaaatggaa aactacattg tgatgacgac 2722321 agaatattac tggcattggg atttaaaagg gatgaaaaaa gatgtgtggg aatacagaaa 2722381 gatcatggaa aagatgatga atgcaggcgg attggtctgg tttgcaacgg atgagccgga 2722441 gatcagctcc caccctgcaa actgtctgat ggcccgcatt ggaaaaaacg tcagccaaga 2722501 atcaattgag caatttgaca ggctccgttt ttatcatcgt tatatgtatt aactgacact 2722561 gacaaagggg aaaaaataat gattgttgag caaatcatga aaagagatgt cattacatta 2722621 acgaagacgg atacgcttga aacagcaata tgcaaactga aggaattcca tatcaggcat 2722681 ctgcctgttg tagatgaaga acgacacgtg atcggcatga ttacagacag ggacatgaaa 2722741 caggccagcc cgagtatttt tgaagaaaac aaacgaagcc tatttctcac acgaagcgta 2722801 gattcaatta tgaaaaagga tgttgtctgc gcccacccgt tagattttgt cgaagaaata 2722861 tcagccgtgt tctacgagca tggcatcggc tgcctaccag tggtacacca tcaaaaatta 2722921 ataggcattt taacaaaaac cgatttgctg cggacgtttg tcaaattgac aggcgctgac 2722981 cagccgggct cgcaaattga gataaaagta aacgacatca ccaaaagcct cgctgagatc 2723041 agcagtcttt gccaagacct tcaagtgaaa atattaagcg tgcttgttta tccgcatgac 2723101 gatcccggtg taaaagtgct tgtcttccgt gtaaaaacga tgaatccgct gccgtttttg 2723161 caggcattac aaagaaatgg acaccacgtc gtatggccgt cagagcaaag ggatctgcta 2723221 tgagagacag tgtatttatc tattctccat cctaccaaac ctatatgttt catcaggagc 2723281 atccctttaa tcagcagcgg gttctgttaa catatgattt gcttaagacg atcaatgcct 2723341 ttgatgatgg agacattgtc acccccagac tcgcttcaga agaggagctt tcccttgtcc 2723401 acacggacga ttacattcag gccgtaaagc ttgcgggcgc cggaaagctc cccgctgaag 2723461 aaggagaaag ctacgggctc ggcactgaag acacacccgt ctttgccggc atgcacgaag 2723521 cggcatcact cttggtcggc ggcactttaa cggccgcaga ctgggtcatg tcaggacaag 2723581 ccctgcatgc ggcaaacctt ggcggagggc ttcatcacgg ctttcgcggg agagcatcag 2723641 gattctgcat atacaacgac agcgctgtgg ctattcaata tatccagaaa aaatatagcg 2723701 ccagagtgct ttatattgat acggacgccc accacgggga cggtgtgcaa tttacatttt 2723761 acgataatcc tgacgtatgc acgctgtcca ttcatgaaac aggaaggtat ttattccctg 2723821 gaaccggtca gatccaagaa aaaggaagcg gaaaaggata tggctattcc tttaatattc 2723881 cgcttgacgc ttttacagag gatgattctt ttcttgaggc ttaccggaca gcagcttcag 2723941 aagtcgccgc gtatttcgag cccgatgtca ttatcagcca aaacggcgcc gatgcccatt 2724001 actacgaccc gctgacgcat ttatcagcaa caatcaatat atacgaagaa atcccccgtc 2724061 ttgcacacac tttggctcat caatattgcg gagggaaatg gattgcagtc ggaggcggcg 2724121 gatatgatat ttggcgtgtc gtgccccgcg cctgggccag aatatggctt gaaatgaagg 2724181 gaattgaccc gggtcacgag atcccgccgg aatggattgt taaatggcaa aaacaatgcc 2724241 ccgtggccct tccgtcgagc tggagcgatc cggctgattt atatcctccg attccccgca 2724301 agcctgaaat tacagaaaaa aatgcccaaa ctgtcagcaa agcattatat gcgatacgtt 2724361 ctgaacagca aagaacaaag taaaaaacga cctttacgaa gaggtcgttt ttgatttttt 2724421 aatcactatt tccacacgcc gattttcctt catgtgttca tttgtcttgt tatcctttac 2724481 tggctttgta tccgcataac cgacagcaat aaagcgcttg gagggaagct tctctttaga 2724541 cgtgaagtat tgaatcactc cacttgcccg tgctgctgat agctcccagt tcgacgggta 2724601 tcggtatgtc gaaatgtttc ggctgtctgt atgtccctca acctgaatgt catttggaat 2724661 tgtttgaaga agaacggcaa tttggtgaag aagtgtttcg gcatttttca gcacctttgc 2724721 ctcacctgta tcaaacagca cagcctcctg aagaacgagc acgacaccgc gttcatcccg 2724781 tttggctgtc atttgggcct tcaaatgatt gtcttttata tatgtattta ctttcttgag 2724841 aagctgatcc tgctgatcct cttgcttctt cgtatcagat ggggatgtat tctttttttc 2724901 tatggatgtt tggtccggct gaagcccgtt gccttccttc tggatcgagt ccactgccgc 2724961 tttgaatttt tgcagatcga tttgggacat cgaaaagagt aaaataaaga acacaaggat 2725021 caaggtgatc agatctgtaa aggttaccat ccagctggat gaagattgac tgttttttcc 2725081 gcttccattc cttctttcaa aacgttctct tctaagcttc atgtacagat cccttttttg 2725141 tttttacttg ttttggctgc ttctgccatt cttcccgtga gctgaaaacg accagctggc 2725201 tttcaaggtt gcgcgggttt tttccggatt gaacaccgat aatcccttcc accattacct 2725261 gcttgatgaa aatttcactt tctgttttct cttcaagctt agccgcgatc gggttgaaga 2725321 ccatatttgc cagtaatgaa ccatataaag tcgtcagaag cgcaatggcc atgtttggtc 2725381 cgagcatatg cgggtcgttt aagtttttga gcatcagcac aagcccgacg agtgttccga 2725441 tcattcccca tgccggagcg aattctcccg ctttttcaaa aactcgccgc ccttttcggt 2725501 gccgttcctc cattgctgcg atttctgaat ccatgacgag ccgaatcgtt tcttcatccc 2725561 agccgtcaat cgctaaaagc agcccttttt tcaagaatgg atctttgatt tcccgagcct 2725621 gatcatccaa tgataaaagc ccgtgttttc gcgcgtgatc ggaaagggaa acaaaggttt 2725681 tcacaagatc tttcacattg tcttcctggc ggatgaatgc ctgctttaac acagagggcg 2725741 cttttttcag ctcacttggc ggaaaactga taaaaacagc ggcgcaaagt ccccctgtta 2725801 cgatgaagaa agaggtcaga tcaagaaaag agcggaaacc gcttactccc gatcctgaaa 2725861 taatcccgat aacaataata atcgttccta acacaaatcc aacaggtgta agataatcaa 2725921 aacgtttcat catttctccc catgaaaaaa gcaagaattc accataaagg tgaagcttgc 2725981 tctttgtttt tcttatgact tggttgactt tctaagctct atacggtgcg gcagttcgac 2726041 gatatgctct tcaaccggct ctttattcat gagcttcgtc agcagtctca tcgcaacggc 2726101 gccgatatca tatgtcggct gaacaactgt tgaaagctga ggacgaacca tgaggcttaa 2726161 tcttgtatta tcaaaaccga taatgtcgag atcctccgga atggataagc cctgatcctg 2726221 agcggcatgg ataatgccga gtgccatttc atcagttgca gaaagaatgg ctgtcggttt 2726281 tttatccagg ctcatcagat gctgcagtgc ttcgagtccg gaatcatatg tgtaatcccc 2726341 ttcagctaca aattgttcat taaacggaag gttcgcttct tcaagcgcac gtttgtagcc 2726401 ttggagtttt ttcgaacggt tgatcggttc tgccattggt ccggaaacga acgcgatgtc 2726461 tgtatgtcct ttatcaacca aaagcttcac ggcatcataa atcgcctgtt cgtaatcgat 2726521 agcgactgac ggtgtttcct cctgctcttc tacagaagcg gcaagtacaa tcggcactgg 2726581 agaacgctta aattccgcca catgctcgtc cgtaatgttt ccgcccataa acacgatgcc 2726641 gtccacttgt ttgccgagca ttgtgtttaa caagtgcagc tctttctcca tgttttggtc 2726701 agagttgctc aaaataatat tgtatttata cattgtcgcg atatcttcaa ttccgcgcgc 2726761 aagctctgaa tagaaaatgc ttgagatatc gggaatgatg acacctacag ttgttgtttt 2726821 tttacttgcc agccctcttg ccaccgcgtt tggacggtaa ccgagacgtt caatggcttc 2726881 caagactttt ttcctcgttg tcggttttac attcgggttg ccgttcacga cacgggaaac 2726941 ggttgccatg cttacattag cttctctcgc tacatcgtag atcgtaatat tgctcatcct 2727001 aaaaccactc cttttactgg atacacttat ccttatctat agcataaaca ctttatgtag 2727061 agaaatgtca taatgtccga atttatgtcg tttatgattt gtaagcgtaa gtcagtagtg 2727121 tacattattt ttcattattc atcaaattta attacttctc atgaaattat acacgttttt 2727181 atagatgatg aaaacgtata cttggttttt ataactaaat aaacgagaaa gcataaaaaa 2727241 aggccgcagg cgcggccttt tggattgttc aattaagcgt tgactttcac cattggcttc 2727301 agttcattca gccatttttc gaattcagga atcgccattt gctgagcaga gtcagaaagt 2727361 gcgactgacg gatcagggtg aacctcagcc attacgccat cagcaccgat cgctaaagcg 2727421 gctttagctg tcggaagcaa gaggtcacgg cggcctgttg aatgcgtaac atcaacaaag 2727481 actggcaaat gcgtttcttg tttcaaaatc ggcacagctg aaatatccag cgtgtttctc 2727541 gttgctgttt catatgttct gattccgcgc tcacaaagga taatttggtc atttccttgt 2727601 gacatgatgt attcagcagc attgatgaat tcagagatcg ttgcagcaag accgcgcttc 2727661 agaagcactg gctttttcac ggcgccggcc gctttcagca attcgaagtt ttgcatgttg 2727721 cgcgctccga tttgaatgac atcaatgtag tccagcgctt cttcgatatg agccggagtt 2727781 acgatttcac tgataaccgc cagatcaaat tcatccgcta cacgttttaa aatttgaagg 2727841 ccttcaacac caagcccttg gaaatcgtat gggctcgtac gaggcttaaa ggctccaccg 2727901 cgcaaaattt taatcccttg ttttttcgca gctgcagcga cttcagctac ctgctcatag 2727961 ctctctaccg cacatgggcc gacaatgaat ctttgctggc cgtctccgat tttttcgcct 2728021 ttgatatcaa caattgtatc ttcaggtttt ttcttgcggg agacaagcag cgctttgctg 2728081 tgatcttctt cctgaagctc taaaccggct ttgaatatct ctttaaaaat gtgctggatg 2728141 gttgaatttt cgaacggccc gtcattgttt tcaatgatat tgtttaacat tgtgcgttct 2728201 ctgacagggt caaatcggtt gacaccctgt gcttccttcg ctttaccgat ctcttttaca 2728261 acattgccgc gttcgttgat taattttaaa atttgtaggt ttaattcgtc tgctttctgc 2728321 cttaaaagct ctaactctgt gttgctcatt tttttcatcc tttccctgca cattcatttt 2728381 ttattttgta gttatcatgc atcttactat aagtaattcc aaatggaaat actgaaatac 2728441 aaaaaatttt ataaaaactc tactttatta cccaaacgct tttaagtgat aaagtaatct 2728501 atgaagctat cctacatgat gtgagggcaa tgttcaaggg ttttttacaa aaaaaagcgc 2728561 cagatgatat ctggacgctt ttttctatga caaatgctgc tcaatagcgg cttctgtaat 2728621 ttgtgaatgt gaggtatgcc atttcacttc accgttctgg atgatgaata tctgagggct 2728681 ttcatgcttg accccatatg tttctgcaat gaaattggac agcggccggg cttcttgtac 2728741 ttgaagatag taagccggca catcctcatg ctgatttgca aaggcatcaa actcatgaaa 2728801 tgctgcctgg ctgatcgggc atgtggtgct gtgtttcaag aagacgaaaa cgccttcctg 2728861 ttctgcaatc cgtttaaatt cttcctcaga ttgaataagc tgtttagcca tgactcaagc 2728921 tcttccttcc ctgctcagcg attcaactgc tcagcctgtt tttgtgcatc tttcagttcg 2728981 tcttttacat cttctttcgt ctggaggact tgatcttttg tttcatcagc tgcctgcatc 2729041 gcttcttccc tcatatcttg cattgcagtc gatgaatccg ttttgtcaga tttggaacgg 2729101 tctctcaaat cctttacctt gttcatgatc tgtccagact gatccgctac aagctgtgtg 2729161 atgttggaag ttttgtcttt tgcgatgctg acatattgcg tgcctttttc cttcgcatct 2729221 gccgtcattt tatcagtttt gtcccgtaag gcaacagcct ggctgccgag atcgtcgcga 2729281 agttctttgc ctgatttagg cgctagaaaa agagctgtag tggcaccgat gattcccccg 2729341 attaaagttc cgattaaaaa atctttacta ttaattccat ctttgctcat cattattcct 2729401 cctcttagta tttttttctc ttacagggct gattttttct tttgcttcca tttctcccaa 2729461 atttccattg ctgcttgact ccaagtgaca acttgattga tcttatcttg attctctcta 2729521 actgatgccg atacagaccc tgccgcttgt ttcatggatg tattgaactg ctgtacagaa 2729581 gctcccactc cttgaacagc atgaacgacc gtgttcagct tttctgattt ttcctgaata 2729641 tcttcagcca ggcggttggt cttatgtaaa agctcggctg tttcagttgt gatgcccttc 2729701 atttgtccct ccagcccttc aagagtggat gcgacgtttt ttagtgtcag ctgcagtgac 2729761 ttcaatgttt tagacaagta gatcactaat acgagaaatg caactgcgat gagtgcaacg 2729821 ctcaaataaa gaataataat catctcaaac ctccttgctg caggatatac tgctgtttac 2729881 ccgttttctt caatcataaa catgtgtact gggctgtata catactattc tccgttatgt 2729941 aagaaaatcc tttaataagc tttcccatca gataaataaa aagcagtgag atcactgctt 2730001 tttattatgc catgacgttt tcgtaggctc tcatatattt ttggatatct cctgctccca 2730061 tgaagatgag aacggcttta tcatgagctt ttaaaacaga tgtgtcatct tcttcaatca 2730121 gcttggcatt atgaattttt ccctggagat caccgatcgt cagctttccg gcattctcac 2730181 gggctgagcc gaaaatatcg cataaataca cacagtcggc gccgctcagg ctttctgcaa 2730241 attcgtcaag gaactgctgc gtccgggtaa atgtatgagg ctggaatacc gcgacaattt 2730301 cccgatcagg atacttctgt cttgccgcct cgattgtcac ttttatttct gtcggatgat 2730361 gggcatagtc atcaatcagc acttgatccc caagctgctt ctcattgaat ctgcgtttga 2730421 cgcccccaaa ggatttgaga gcatgcttaa tgatgctgga atcaatttct tcataatggc 2730481 ataacgcaat gaccgccaat gagtttaata cattgtggtg gccgtacgca ggaatataaa 2730541 acgtatcata gaacgtattg cggacaaaga catcaaaagt tgtcccttcc gtgcttttta 2730601 cgatgtttct ggcttgaaaa tcattttctt cccccgtgcc ataatacaca accgggacgt 2730661 tcgcatggat tttcggcaga tgctcatcgt ctccgcaggc aataatgcct ttgttgactt 2730721 gaagagccat ctcttggaaa gcgtcaaata catcgtcaat gcttgagaag taatcagggt 2730781 gatcaaaatc aatattcgtc ataatcgcat aatctggctg atagcttaag aaatggcggc 2730841 ggtattcgca cgcttcaaac acaaagtatt cgctgttttc atttccctgg cctgttccgt 2730901 ctccgattaa gaaagacgtc ggttttgcgt tttggatcac gtgagccagc agacccgtag 2730961 tcgacgtttt gccgtgtgcg cccgtaacgg caacactcgt gaattttttc atgtagtcgc 2731021 ctaaaaactt atgataacgt atcaccggaa ttccctcaga catcgctttt tctatttcag 2731081 gatgcgtgtc tgggaatgcg tttccggcga tgactgtcat gccgggttta atattttccg 2731141 cgctaaaagg aagaatcgta atatttcttt tttcaagcgc tgtttgcgta aaaataaatt 2731201 tttcgatatc cgatccttgg acagtatatc cattatcatg aagtatttgg gcaagcggac 2731261 tcataccggt cccttttatt ccaacaaaat gataaacagt cataattgta cctccaacaa 2731321 acgtctatct gttccccagt atatgacgct catttcaatt tgcgaccgcg gcggctgaaa 2731381 agcctccctt agcggcgtat tttatatgtt ttgttatgtt tagtatcagg ttatttcttt 2731441 ccgattaaac ccagatatca agatttgtct atgcacagct gctgtaaagc ggcatagctg 2731501 ttaaatgctc taaacactat cataccatgt ttggtgtgaa aatgaaccca tattattcgt 2731561 ttattaaatc acttgctgtg atcagcacct ctcgaggctt gcttcctttt gcctcagaga 2731621 tcatgccttc cgcttccatc atgtcgatca gccttgccgc acgattgtaa ccgattctga 2731681 atcttctttg caggcttgaa gtgctcgcac tgttttgctc tacaacaaac tcacacgctt 2731741 cgtaaaacag ttcgtcctct tctttcaggg cagatccttg tcttacgagc tcttcttgtt 2731801 caaataaata ggtcggcggc atttggcttc tgacgtggga aacgacgcgg tcgatttccc 2731861 ggtctgacac aaagttacct tgcagacgaa ccggttttcc cgagccgttt tccaaaaaga 2731921 gcatatcccc ttttccgaga agcttttctg caccggctat atcaataatt gttcgggaat 2731981 caacctggct tgagacagaa aaggcgattc tcgttgggat attcgcctta atcagacctg 2732041 taatgacatc gactgacgga cgctgagttg cgacgagaag atggataccg cacgctctgg 2732101 ctttttgggc gatccgcgca atgctttctt ccacatcgtt tggagccacc atcatcaaat 2732161 ctgcaagctc atcaataatg acaactaaat acggcagctt ttcacccatt tggtgttcag 2732221 cggttaattg attaaagcgg tcaatgtcgc ggacacctga atgggcaaaa agctcatagc 2732281 ggcgctccat ttcctcaacg acccatttca aagcagccgt agccgcttta gcatcagtaa 2732341 tgaccgggct gacgaggtga ggaattttat tgtaaggggc cagctctacc attttcggat 2732401 caatcagcag cacctttacc tcactcgggt cagctttata aagcaggctt actaatattg 2732461 tattgatgca tacgcttttt ccggagcctg tagcgccggc aatcaagcca tgcggcattt 2732521 tcttcaagtc gataacaaca ggatttcccg aaatatctaa tcccagcgca gctgtgagcg 2732581 gtgacttgct tgtcctgaaa gctgagctgc gaatcatttg gcgcaaatca accaccttgc 2732641 tcgtgcggtt cggcacttca attccgatcg tgtttttccc cggaatcggc gcttcaatcc 2732701 gaatatcttt agctgagaga ctgagtttaa tatcatcgga caagttggtg attttattca 2732761 cctttacacc cggttcagga tgcacttcaa atctcgtgac agacggaccc tgggttacat 2732821 ggaccacatt ggcgcggaca ttgaaatttt tcaaggtcaa atcaagaagc tgacgctgtt 2732881 cttcgatcca cgcagtatca tcttgaacct gcgctggcgg gacatcaagc agtgcaacat 2732941 tcggaaatac atagctgccg cggcgctcct ctgctttttg ctgtttatgc gtatctcttt 2733001 tcagcatcat cacattaaaa ggaacggatg gccctttttg agaagatgcg ctttgttcag 2733061 tccttttctc ctgtacacca ggcctttttt tcggctcttc tgaagcttcg cgaggtttgt 2733121 ctgcgcgaat ttcctgccgg ttttcaagag ttgcagtaga cgatttggaa ccctgctcca 2733181 tgtgttcagt tttctcaagc tctgtatggc tgtctggctg aacatctatc ttcgtttcct 2733241 gagcctctcc cagggtgtca taatgattat ttattatgct ttctgatggc tcttctgatt 2733301 cttttgccac agtttctgct tgagccagag cctctgatga atactcatga tcagtaaata 2733361 aaggctcttc ctgacgaatg tccatttgtt cttcttgaac gaacggggac tcagcacctt 2733421 ctgccgcgtt ttcatgatga ttgtatactg ggctgtctga cggctctttt gctttttcat 2733481 cctcagatac tgcctctgtc tgagattcag gagctgtttg ctcttcatca agttcagcgg 2733541 agaaaacagg ctcttcaaat ttctctggct gctgctccct ttgttcttcc tcagccgttg 2733601 caggctcttc gcggcctact tcactgtctg aaagcccttc agccgccgta tctgtgagca 2733661 tctcaggcgg tgtttgctct tcggcttgtt cagctgggaa gaaaggctcc tctttttccg 2733721 gctgttgaac gcctgactca aatggcactt tgttacctga cggctcggct ggccgtttcg 2733781 ccagcgcctc atcatgctcc gtatcctttc tgtttaaaac gccagaaggc tgtttttcaa 2733841 attgggtatc cgggaagaaa ggactttcta ttttggaatg cgcctgtgtg tctgaagcag 2733901 gatagccgcg ttcacgttcg atctcttctg acagcagtgt taccttctct tttaccgatt 2733961 tatccggttc gttcaatgtt tcagaaggct ttttcggcac atccttttta acagatggtt 2734021 tttgattgaa tccatagaca ggcgaaggga tatttgtcgg tttaaacggt ttcttcgccg 2734081 gctctgctgc ttgatatgta tgctgctctt cttcatttct gggacgctct ctgtaaggtg 2734141 cagcacttgg acgaggcgcg gatttcggtt cgtccgatgg tgtgcggcgc cttctcaggt 2734201 catgattttt gtatccgtca ggcacgactg gaaaacggaa tttgcctttt ggatattcat 2734261 aatatatttt aggatcttcc aatcttttta attgtccttc aggatgatgt acttcttgtt 2734321 gctgcggaat ttgagcgggt tttgtctccc gttcagcatc ctcttcgctt tcgcctaaaa 2734381 acaaatcaaa aaatttatga agccaactca taatttatct ctaactccct tatagttttc 2734441 tgggacggtt tttagtatac cactgctggt cggcccagaa aagattaagc tatcagcaga 2734501 aacaaagccg ctaaacaagg gcttagcggc ttttcacatg attcgttttt tttggcggat 2734561 ttatgggagt ctaaaactga aatgcgtctc ccgcctcata gtctccttct aacacaagga 2734621 ttcctttttc agcaggggca tccggcaaat caagctcttt cgctgagcag atcatcccgc 2734681 ttgacggaac gccacgaagc tctgcatcct taatgacaag tccgctaggc atcacagcac 2734741 cgactttggc aacgacaact ttttggcctt ggtcaacgtt aggcgcgccg cagacgatct 2734801 gaagcgtttc ttctcctacg ttgactttac atacgcttaa tttatccgca ttcggatgtt 2734861 tttcttttga ttctacataa cccacaacaa acttcggaga taaatcaacg actaatgttt 2734921 cttcaacgcc gtttctgttt aaaatctcat tcacatcttg cacgaatgtt tctgagagcg 2734981 caacagggcc gttttcatca atggtcaagt aagaagacgc attgaaaatg ttgaagcccg 2735041 ttgtttcttt tgtttcgtta ttgaaaattt tgacgacgtc gccgtgtttt tcatagccta 2735101 attgttcgcg tgtcacatct tgaagagaga tcaggagcgt gtctcccaca ccttctttat 2735161 tataaaaagc gttcataagt aaaaatcctt tctaatcctt tttcggacgg cttttcgcca 2735221 ggataaacac cggttccagc tttccttcat tgtacaaaaa tgatagggcg gtaatcggga 2735281 cggtgccgcc tgcaaagaag ctcatcgaca tttgtcctag aatatcatac cccgattcat 2735341 tccggatgtc agcaagaatc aaaacgtcct gatgaggaac agagatcgcc agctcacctt 2735401 ctgcatgctg cttatactca tttaagatcg cttcgttcaa aatccggctt gcgtcgtatc 2735461 cgtcgtttgc cctgaagaaa taaaagtaat tgccggcaac cgtatcctct ttgacaaccg 2735521 tcggcaggga acggagatta aatgcggccg tctctctgat ccgctctttt gtccagtttt 2735581 ctttctcaag catgcgctgg tcaattaaac ggtaggtttt cccgagatct agcgcgtaat 2735641 aaattcttgt ctctgcggta tgatcgtcat aaatgagcgg gatatcttcg ctggacttgt 2735701 ccgggaagga agtcgagcgg atgaccggat aaatgcgagt ttctttcccg gtcatttcct 2735761 gagccttccc ttccattgcc gtcatcgctt cggagacata gtacacgatc tcatcaatgg 2735821 cttcgtcttt tttcagttcc cattttgcaa taatcggcgg caaatcgagt gtaatccctt 2735881 ttttagtcgt ttgatcctca acacggaggg tgtctttttc tctgtcaaac agaaaggagc 2735941 gattctcgtg ctgaaggcgc tgcttcagta tatctgacag cttccttgag gtcattttca 2736001 aaccgatgtc ctcctttacg ctttagcgag agagtctgtt aaaaactgtt caatttcttc 2736061 ttttgttttg cggtctttgc tcacaaaacg atttacttct tttccttcat taaacaccac 2736121 aaagcttggg attccgtaaa tttcccactc tgcacatgta tcaatgaatt tgtcacggtc 2736181 tacgtagtag taggtgaatt cagggaaatt cgcttccagt tcaggcagga aaggctctac 2736241 aaaacggcaa tccgggcacc aatcggccga aaacataaat acagaccaat catcctttac 2736301 cgctttttcc agctcttgag ttgattcaat ttttttcatt tcatatccct ccagttgttt 2736361 atgttcttac atgtttttta tcgatactcg tccatttgga tcataccaaa ctgcttgagg 2736421 caaaaccact tatatgcaac gaatgaatat gtaagattgg ctttcccatt atcattatca 2736481 tattttattt gcattatcaa gctcgtttcg tttaacatcg tgtacatgag ggtgaaattt 2736541 acagatggat atacataagg agggattttt attatggagt ttatcgtcta tttagcagga 2736601 gaaatccaca gcaattggcg cgaggaaatt aaagaaaaaa caaaatcact gaagctcccg 2736661 attacgtttg ttggcccgat ggagaatcat gaccgctcag acaatattgg tgaagaaatt 2736721 atgggcgtac agccaaatgc cgttttaaag gatgacaaag cctctgacat caacaacttc 2736781 agaaccgccg tcctgatgaa taaagcagac tttgtgatcg ccctgtttgg cgaaaagtac 2736841 aaacagtgga acacggcaat ggatgcatca tatgcgatcg caaaaggaaa acccctgatt 2736901 atcatccggc cggaatcgct ccaccatcct ttaaaagagc tttccaataa agcgaatatt 2736961 acggttgaaa ccgttaacca agccattaag gccctttcct atctatttga aacagaataa 2737021 gaaaaaagct tgtcgatccg ggcttactgc tcgttcaaca agcttttatg aaacctacat 2737081 attttcttta atcgcatcca ctgtctgctt atcgcaggct gttacaagtt tgatgagcat 2737141 ttctttagca gcagcataat catcaatatg aatgatagta gcgtttgtat gaatatagcg 2737201 ggaacatatt ccgataaccg ctgacggcac accgctgttc gaaatatgaa ccttgcctgc 2737261 gtctgttccc ccgccggata caaaatattg atatggaata tcatgcgttt cagccatatc 2737321 aagaacgaat tccctcattc cgcgatgcat gactgtcgtt ctgtcaagaa tgcgcagcaa 2737381 aaagcctttt ccaagctggc cgaattcatt tttgtctccg ctcatatcgt ttgccgggct 2737441 ggcgtcaagg gcgaaaaaca agtccggttt aatcatatga gaagccgtct gcgcgcccct 2737501 tagccctact tcttcctgaa ccgttgcacc cgcatagagt gtattcggaa gctctttacc 2737561 gtgtaattcc ttcagaagtt caatgcttaa gccgcatcca tatctgttat cccatgcttt 2737621 tgataaaatt ttcttttcat tcgccatcgt cgtaaacgga caaacaggca cgatctgctg 2737681 tcccggtcta atgccgattt tgatggcgtc ttccttatca tccgctccaa tgtcgatcat 2737741 catgtttttg atatccatcg gtcggtttcg ctgcgcatct gtcaataaat gcggcggtat 2737801 gcttgaaatc acacccggaa ccggcccgtt atctgtttga atttcaaccc gctgcgcaag 2737861 caaaacttgg ctccaccagc ctccgagcgt ctggaatctg agcagcccgt tgtctgtaat 2737921 ggatgtcacc atgaagccga cttcgtccat gtgcccggct accataattc tcggtgcgtc 2737981 ctctgcgcct cgtctgactc cgaaaacact tcccagtctg tcctgaacga tgtcatctgc 2738041 atatttggct agctcctgct tcataaaagc acgaacctga tgctcattgc ccggcgcgcc 2738101 gggaagctgc gtcagtgttt ggaaaagcgc tttcgtttct tgattcatgt tttcccctca 2738161 tttctatgta gtccttttat tttattagaa acaatgaagt tttccaagca ctctgaccca 2738221 atctgctcga tcagccgcgt attgcttaac aggatttggc tgtttctgta taatgaaaag 2738281 tacgatcaac caggaggtgc tttattttga aattgcgtca tcttctttta ggagcaggac 2738341 ttggaatttg tacggctgtc gttgtgagac aatatgtgat gaagccttat atttcttcag 2738401 aaaaagcgct tcgaattgta aaatctgctt ttaagcagcg gggcccgatt gacggatcat 2738461 ggatttacac ccagccggag ccctacaata ttaacggaga aacggtacag gtatacaaaa 2738521 ccggcattac acgatcagct ttcggagaat tagaacagta tgaagtcatg gtggatgcga 2738581 aaacgggaga aattgttgat gtcattgata caatcgcctc ttaacaccgg acaagcaaaa 2738641 aatagaagcc gctgcctatg cagcggctct tttttattat atcgcgcgaa tcggtttgta 2738701 taccggatac cacatcgcat cctgcactgc ctgtataatg tcttcaggct cttccgtagc 2738761 gacgccttcc ttcattgcgg tttttgcaac ttcaacagca acggttgccg aaacagtgcg 2738821 caaatcttca acttttggaa gcatcggcgc cccaggcacc ccgacattga ccatacctgc 2738881 gattgcccgg gcacatgctt caaacatgcc gtcggtaatt aattttgatt ttgtaacaat 2738941 cgttccaaga ccgagaccag ggaagacaag cgcgttgttt gcctgcccga tatgatacgt 2739001 aactccgtta tattcaactg gcgggaacgg gcttcctgtc gtgatcagcg cacggccttc 2739061 tgtccattcg attaaatcct ccggctttgc ttcagaaaga gttgtcggat ttgacattgg 2739121 caaaatcgcc ggccgtttca catgtgacgc catttctttt acaatttctt cagtgaaagc 2739181 gccggaaacc gtagatgtgc cgatcaggat cgtcggtttc gcctgccgaa ccacttcaag 2739241 aagatcaatg cctccgccgt ctccgttccg ctgataatcc ttcacttcat cagccgaacg 2739301 ggcatacggc ttttggaaat caagaagctg atccatatca tctgttaaca gcccgttcct 2739361 gtctatgcac cagaagcgct tgtatgattc ttcttcactc agtccctcgc gcaccaatgc 2739421 ttcccgcagc tgttcggcaa ttccgattcc tgccgttccc gctccgaata taacaactct 2739481 gtgatctctc agcggaactt tagacgcttt tgcacaggat aagactgcgg ccaaagaaac 2739541 agcgccagtt ccttggatat catcattgaa ggtacacact ttatctttat agcgtttcaa 2739601 aatgcttcgc gcgtttttcg ccccgaaatc ctcccaatgc agcaatgcat tcggaaatgt 2739661 ttctctcgcc agcgcaacgt agtcgtcaat aaattggtca taacgttccc cgcgcactct 2739721 ggaatgctgg ttgccgacat aaagcgggtc gttcaagagg ctctcctgat ttgtccccgc 2739781 atctaaaaca acagccagca ctctgctcgg atcaatgccc gcagccgctg tataaaccgc 2739841 cagcttgcca atagaaattg cgattcctcc gacgccccag tcaccgattc ctaaaattcc 2739901 ttccgcatca gttgcaacaa ttaaatcgat cgtatcgctt tgatctttat actgtttaaa 2739961 agcttctttc ataccgtccg ggtcatcgat tgacagatag agccctcgtg gttttctgta 2740021 ttcatggctg tatctctgaa ttgccgttcc gactgtcggt gtgtagacaa tcgggagcat 2740081 ttcccctaaa tggtcattta acaggcggta aaacagcgtt tcattccgat cgtgcagcgc 2740141 cgttaaatag acatttttgc tcaaatcgtc aggctgtgcg gaatattgtt catacgctct 2740201 tttcgcctga tcatcaattg ttaatacctt gggcggcaga aagcctttta aaccaagttc 2740261 ttttctttct tcctcagtaa aagcaacacc tttgttcaaa aaaggaacag agagcacttc 2740321 aaggcctctt aatgttgttt gaatgtctcc ttcgtttgtt actctgaatt gtttcaccct 2740381 gcctcttcct ttctgagcat aatagtacta ggtttgcatt attagccgga aaacatgcag 2740441 ggtaaacata aaaatatgct atcgcttcat tcgcttaact gactttttga tgcttccgtc 2740501 ctcctcccat tgaagggcgc gatactcggc atcatggtaa aaaataaacc aagcatcttt 2740561 ttctgctgcg aacgcctgcc atttctgctt ttgcgggata gaggtcatcg gataatcatc 2740621 gtaagccagc acccatagcg gattgcggtg ggcatgtgtc ggcatcagat ctgccatatg 2740681 tacggcagtt tcacccgcat cctcgcatat caggacactg tgtccgtcgc tatggcctcc 2740741 ggtgtgatgc attgtaatac cctctgtgat cgttaaggtg tcttcaaagg ttttgacttg 2740801 gccagctaca gcctcccaat tttctttcca atacgtattt ttcgacctga tattcggatg 2740861 gcgcatttcg tcccattcaa cagctgatgt ataaatcact gcattcggaa agacagagac 2740921 gagccgttca ccttcatatt ccgttaaacc gcatgcatga tcaaaatgaa ggtgtgtcat 2740981 tgcgatcaca tctatatcgg caaccgttaa tccgagtgca gctaatgagg gtttcacatt 2741041 cgactcttgt gtcacgccat agtttcgttt ttgtttatca gtcagcttgc cgtacccaat 2741101 tccggcgtca atgatgatat tgagcccatc cttttgaatc aaaatagggt ctgttcttag 2741161 ttcaatctgg tttttttcat tgactggata ttttttagac caaagcggct ttggcacaac 2741221 gccgaacatg gcgcctccgt ccatatgcgt cacgcctccg tcaagccagg tcaacgtgat 2741281 gtttccaatt ttcattgttt ccattttcac ccccccctat catcatggta gcaaacggcc 2741341 cataaaaaaa acagactcct gtcagagtct gtctttacgt tctccattca acctcagccc 2741401 gatagatcgg ctggccgagt gcagagaatt tttcttcata ttctgtcata atattgcctt 2741461 ccagattgct gttatgcaaa tcgagactga cgtatgtcag caggaggccg tactcagaga 2741521 agctcttcaa agagtactca aataaacctc ggttgtccgt tttaaaatga atcgatccgc 2741581 ctttgcccat tacttcttca tattttttga ggaagtggga atatgtcagg cggcgttttt 2741641 catgccgttt cttcggccaa ggatcagaaa agttcaagta gacccgtttc acttcccccg 2741701 gctcaaacac atccgtcagc gtgtccgcat ctatattcag aagctttaca ttctgcgctt 2741761 cgctgtcttt tactttttgg acggctgtca cgatgacgct tttaaataac tcaataccaa 2741821 tataattgat gtcgggattt tgtttggcca taccagaaat aaattggcct tttcctgtac 2741881 caacctcgat atggatcgga ttgtcgttgc caaacactgt gttccatttc cctttataat 2741941 cagcaggatt gctgatggca atatctgcgt tttcagccaa aaagtcatca gcccaaggct 2742001 tgtggcgcat tctcatatga ttgacacctc tatctattat ttcgactaac aacataccat 2742061 gaattaaaaa gacccgcaag ctcgtttttc cagtgtatct ctcttaaggc cgagcgcata 2742121 aaaaaagagg gtcccgtctg ctggaacact cctttcccat gtataaaaac gctctgtttt 2742181 gaacaattta acccgtatga tactgaaggg atgtgtaccg ttatgggttt acattatgag 2742241 catcaagttc atttattgaa ggatatattg actgaccatc aattggactg ctgcggaaca 2742301 gtcgcagagt acgagcagct tgagcgtgtg attaaatcac tgatggcaaa caccgagctt 2742361 gattcaaatt tcaaaaacgt gcttgaagat gtttaccgct acagccaatc aggaatatcg 2742421 tccaaatcca tcgactcaca catacaagag catcagaaca gcctgtctca atgggtagag 2742481 caaatggatt cgtattcctg attaatcaac aattcgtttc atgaggatat gcagctcttc 2742541 cattgcatca tgaaattcct tatcattgcc ttttgcttta tgccaggcaa tgaaagtaat 2742601 tgtttcagat aacacatacc aagccattcg caaccgaagg ctttctgtca gctctatgcc 2742661 gtacatgctc agccagctct cccaagctgg cttttcgacg tagtggtaca gcaaaggccc 2742721 gaggtccatc gccggatcag cgatcatggc gccgtcccag tcaattaaat acagctggtt 2742781 gtcttcagac aatagccagt tattatgatt gacatcacaa tggcaaacga ctttctcacc 2742841 gaaatgcact tcatgcaggt gttcttccaa atacttgatc ccttcttgaa tcagcggcga 2742901 agattgctgc acagcaaata cagcctgctt cagctgagac aaaagagccc ccgggttcag 2742961 cggttctttt ccaagtctct tcagcatgtc cagcaaggct tttgatgtgt gtattttacg 2743021 aagcaattca gcaacgggcc gtccgctcat gtctttaggc ttcagctctc tgccggtcat 2743081 ccagtgctgg gccgtaatga cgtccccatt ttccatccgt tttgtccaaa ccagcttcgg 2743141 aacaatgcct tcggcggata aaacagctaa aaaaggtgag ctattacgtt ttaaaaaaag 2743201 ctgctgcccg ttatgtttcg cataatatgc atctcctgta gctcctccgg cggggaagat 2743261 ctcccaatcg ctacctagta attgtcccaa ccagttcata tcaatgttca acccatcatt 2743321 tcttaaaata ttttagaatt aaggctaatc gtttctagtc tatccagcga atgccttttt 2743381 cgtacgaatc gtataaaaat aaaaaagaca gctattgaga gtctcatatg ctaatcaata 2743441 gccgtccttt aaattttagc gctatagcac aaacttcgtc aagcaaaact cttaagatct 2743501 gatgctaaat ataagataac cgttccgatg ccgtttactg caaccgtttt cttgatttct 2743561 gttgggtctt cctgaaatcc tgatggatca cataaaagcc gataaggtat gtcgtttggc 2743621 agcctccact cgacggagtc tggactcgcg tgatggataa caatgatatc tttccattcg 2743681 tcaacctcgt caagatcata aagcctgtat gcgataaggt gttcttttag cgtcaagcat 2743741 tcaagatggc gctggatgtc tgcagcggac ctaagacgga atgcaggatg cgcttttctc 2743801 agcgagatca gcctgcggat atagtgaaca tcttctttga atgtttcacg gcgatcccag 2743861 tcgagctggt tgatgctgtc actggattga tagctgtttt ccactccctg cttcgtccgg 2743921 aaaaattcct ggccgctgtg aataaacggc accccttggg caagcaaaat aatcgcggct 2743981 gcaagccttt gcctgcttcg ctttcggctg tcattttctt gaggaagcgc aaagctcatt 2744041 ttatcccaaa aggtgtgatt gtcgtgtgat tcgacataat tgatggactg gcttggttcc 2744101 ggaacaatcg gtgctaatgc cttccatccg gaagacccgg caattccatg catcacagct 2744161 tgtgctgatt caccgttgcc gagcgcaaac cctgttgcct taaggtgaaa ggtgttccct 2744221 tttacagcgt cacgaaacat atcattaaaa aagccgatgc ccggcattct tggcgcgttc 2744281 gccaaagcag ctttctgttc atgcggcagc ggtgtagcca ggtcccaccc ttctccaaaa 2744341 agcaggattc cgggctttgc cttagttgct ttctctttca tataaagcac ggtgtcaata 2744401 tctaaaatcc cgaggagatc aaagcggaag ccgtcaacat tgtattcttc aagccaatag 2744461 accacgcaat ccgcaatgaa ttttcttgcc atccttcttt ctgatgcaat atcattgcca 2744521 acgccggtgc cgtttgatgg catcccacat tcgtcgtgcc ggaaaaaata accgggcact 2744581 gtcttttcaa agggggaatt ctccctctta tacacatggt taaaaacaac atccagaatg 2744641 actcgcagac cgtgctgatg cagggtattg atcatttgtt tcagctctgt ttttctcgtt 2744701 tgaggatcat gaggatttga ggcatagctt ccctccgggg caaagaaatg aagcgggtta 2744761 tatccccaat tgtatgcatc aagcggcttc tcttcatcaa ctccggcaaa atcattcacc 2744821 ggcagaagct ccacatgtgt cacaccaagc tcttttacat acgctaatcc cgaagaactg 2744881 ccatttgcgg tttgtgtatc agtttccgtc agcgctaagt attttccctt gtttatcatg 2744941 ccgctgtttt catggatgga gaagtcgcga agatgcgtct catagatgac ggcatccaca 2745001 gggtgtgaga atggtttaag aggagcagtc catttcattt gatccgggcg caagacgacg 2745061 cccttctctc catttacagt cacagccttg gcatactggt caactgtttc catccattct 2745121 gaattgttgc agatgcaaaa caaatactca tatccgtgaa ggtcacctgt gaccgtaacg 2745181 gcatagacgc ctttttccaa gcgagtcatt tggaatgtgc gcccgctttt attggggtgt 2745241 gaaagcttga cagcagctga ggttgcagca ggcgcccata ctttaaatac ggtatgatcc 2745301 gcggtataaa cggcgcccag ctctccgtca taataaaatt cgtcatcaaa cgctgccgtc 2745361 cggatgaccg cgccaatttg gagatccgtt ttgtggccgc tggatgctct gacgcaatgg 2745421 atttttccaa atgtcacagg atggtcggat acgcagacgt acttgtattt tgcttcaagg 2745481 gagtattcct ccctgacagc cagaggaaaa tctgttattt ctgtctcaag ccgaaacggc 2745541 ggtgtcatga tttccttttg ttcagcagga atcagaacag taatgatatt catgtcatcg 2745601 acatacgctt cgaagctgcg gcggatgctg accatcggaa gctctctcct ccaaacacgt 2745661 ttatgttttg attcttaggg gtgaaggact agatgccaga cgaaacgggg tagtgcccat 2745721 gatttctccg tcagcatgga acgggatttt gtccttcgtg taaaatgtaa tgtccttcgc 2745781 tttaaacatc gtaacgccat ccatctttgt atgttttcca aatgccatga gacataaaag 2745841 ccaatatttt ttcaaaaacg gctggttttc aacgattacg atatcaaatg tcttctcgcg 2745901 cggatttgct aggggcgccg ccttcatgcc tcccccgtaa aacggatggt tggatacaac 2745961 ggcaaaccag acatcatgaa attcgcgcgt ctcgtcttcc gtcgtacaag ctaatgtaaa 2746021 cggcttaaag gttgccgaag cgtgcaaatg agaaagcgga tacacaagaa atcgaaggcg 2746081 gagaaaaaga aaaacccgtc tcaacggaaa ttccatcgcc tttttattga catatgcgtc 2746141 aaacccgatc ccgatatgat tcataaaata aagaatctgt gatttatcct gaaggaaatt 2746201 gacgctccct aaatgaaagg ttcttgttaa cgggcgcttt accttcttga tttcctgtat 2746261 cagatcgatt tttttaatag agaaccctcg cgaaaaatca ttatacgcgc ccgccggcac 2746321 aaagctcagc tcaatatcgt caacatcttt cagcccgttg acaacttcat gcatggttcc 2746381 gtctccgcca atgacgatca ggcgcttcag cttatattcc tgtatcgttg aaatctgtct 2746441 ggcgagcacc tcggcgtgtc ccggatgttc agttaaaaat gaacggtgct caacctttcg 2746501 tttgatcaat tctttttgaa tggacttcca aacacgcagg ccgtttcgat gtcctgctgt 2746561 cggattaata ataaaaaacc aatggctcat ctttctcacc tgcttatgtt atgagaaaac 2746621 cgctcaaatc gttctctttt actccagcca ctcctgtctg cgataggagt cagacatgca 2746681 gtaagacaat agagcctttg cagcctttac ctgatgatgt ttgatcggag cagtgttttt 2746741 cttctgccgc tcaatccatt cttccgcgct ccgcttatcc gctatttcta agccgtatgg 2746801 cggctccggg taatcgatgt acgacgttct gctcagaagc aattttcgaa ccggaatctc 2746861 agcctgtttt tcctttacga tctttgacac aaccgagtcc gtacgaaaca ggctaagccc 2746921 tggatttaac actgatgcag tctgagaggc tgttttcttg tcccaaaaac gatttttaga 2746981 ccctatgtag acactgtctt cctcagcctc taaaaaagaa acgcaataaa tttccagagg 2747041 agaaataatc acaatgctta attcaaccgc cgcctgctga attttcagca caggcttata 2747101 cataataaaa taagaatcag gcagctgctg ggtcagataa cgcaaaatgc ggtcctgctt 2747161 cacttggttt gagagttgag atatttctga aagagtagag cttgcccatt tgagctgaaa 2747221 atcatataaa tgccttttat aaaaagaagc aagcgccacc ctgctcttcg ggagccttac 2747281 atgaatatct tcttcgtcct caaaccattg gtgtctctct tcttgtatat cggcttttat 2747341 ctcttctttt cttcttttca atgaaaattt ttttcgtttc tgcaccggtt ccggttcttc 2747401 agcactggct tgcctttctt catgctggcg ctccgctgct tctactagtg aaagccagcg 2747461 ctcttttttc aaacgtacaa actggttgat ataatggtac ggatcaagct catatctcga 2747521 tatataatca tgaattttga tgatttgtgc catgtttgtt tctccactcc gcaatgaatt 2747581 aagataattg aaatttgaat atttcctcgt attttggtga ttggttcaag tgtatttgaa 2747641 agagcgaaaa tcgttcagcc atcatcgaaa cctcgccgct ttcaaacgga acatgagctg 2747701 gaaatccatc ttcgcctgtc cattttcttg ccagcgtcat atgaggatga tacggtcttt 2747761 tttccacttg aaagccggcc tgaagtacag cctgcttcgt atgttcccgc agtctatcaa 2747821 gcgttttgtt tttctttggc tccagatgta aaacgcgcgg ctttctgcgg tcgccgaata 2747881 catctatctt gccaaactta attgaaaatg gatcaatttc tgaagcaatc tctgctagcg 2747941 aaccttcaag cttctttatt tgtgtctcat ccgccgctcc gagaaaaatt aacgtgatat 2748001 gatagtcaag cgggtgcacc catttttgaa acgtcaatat cggttcgttt ttcgcagcct 2748061 ggtagatcgg atttgcaatt ccctcaggta tgggaacgcc gatgaaataa tgaggccgta 2748121 tatctggcat ccgtctgaca ctcccttctt tgacagctat tattttatca ataaagaggc 2748181 tgtgcggata gaggaacagt gtatgaaaac actctcgcac aaacgtttat tatgttagga 2748241 tattatatga cacttgtttt attcagaaag gaatgacaat gttgaaaatc gttgcaaaca 2748301 cagctgatct gataggagat acaccgctag tgagattgaa tcggcttcag ccggaaaatg 2748361 cggcacaagt ctatttaaag cttgaatttt tcaatccgag cggcagtgtg aaagacagag 2748421 ccgcttatca aatgatcata gaagctgaac aaaacggttt actcaagccg ggatcagtta 2748481 ttatagagcc gacaagcgga aataccggca tcgggctcgc catgaatgcg gcagcacgcg 2748541 gatataaagc aatcttagtt atgcctgata cgatgacgaa ggaacggatc aacctactta 2748601 aagcttacgg tgcagaggtt gtattaactc ccggagagga aagaatgccg ggcagcatca 2748661 aaaaagcgaa ggagcttgcc gaacaaattc cgaacagcta tattccaatg cagttcgata 2748721 acactgctaa tcctgatgcg caccgaaaaa caacagcgcc tgaaatcgcc cgggcaatag 2748781 aggaaatcgg aaaaccgctc ggcgcttttg tagcctcctc tggaacgggc ggaaccatta 2748841 ccggaacagg tgaggcgctc aaagagcttt ttccggatat cacggttcat gttgttgagc 2748901 cagcgggttc gcctgtatta tccggcggaa aacctggcgc gcataaactt gtaggaacga 2748961 gcccaggctt tataccgccg attttaaatg aagacgttta tgatgaaatt atcaaaatct 2749021 ctgatgaaga cgcgtatacg acgacaagac ggcttgctgc tgaagaagga attcttgtcg 2749081 gtccttcatc aggcgctgcc tgcttcgcgg caatcgaaac agcgaaacgc ctctctcctg 2749141 acaaagttgt ggtctgcatg acagctgata caggagaacg gtacttatca actgatttat 2749201 ggtcatttat ttaaaaaaag gactggcttc agcagaagcc ggtcctttta ttttgcaagc 2749261 tcgtaaatgg cctgagcata taacgctgtc gatctcagca ggtcatcaat ttcgatatat 2749321 tcatcctttt ggtgtgcgct gtcagggcgt ccggggaaca gcgggccgaa cgcgacaccg 2749381 gcttttaagg atctcgcata agtccccccg ccgattgaga ttaaatcagc ttttttaccc 2749441 agctggcctt cataaacctt ttgcagggtt ttgactaacg gatgatctgc ggacacgtga 2749501 tgcggcttgc tgtctttgaa ttctcccagc tcaaattcag atgcgctttc gaatgtatcg 2749561 cggatcactt tgctttctgc tgtcacagga tagcggatat tgatcccgag ctcgcctcct 2749621 tgcccttctt tatagcgcag tgttccgaca tttaatgtca gctctccgct gatttcatcc 2749681 tcacagtcga tgtccagttt ttttcctctt gtatcacctg agaacttatc tgtcacaact 2749741 tgcacaaacc gctttcctgc atcgtcaagc tcagtctgct ggagaaattc gcacaataaa 2749801 atgccggcat tgatcccatt gttcggttcc atcgcatggc aggaaagacc gtacatacgc 2749861 aaaatgagct gtccgttctc tattgcagct tccccttttt ggtccgtcgt gcggagcatg 2749921 tctttaaatg aagacagaat ctcttcattt ttcggccctt caatgacagc ttccgcagcg 2749981 tcgggcacca tgtttaagcg aaggcctgat tgaaacgaga caagcactgc ctttggttca 2750041 gcttgatttg ggcggtgcgg aataagtaaa gaagcatcga tgatcccttt ttccgcatta 2750101 atgatcggaa aatcggcgtc aggcgcaaag cccattgttg gcatttcttc atgcttgaaa 2750161 taatgctcta cgcatctcca atcactttct tcatctgttc cgataatcat tctgactcgc 2750221 ttggacaggg gcaaattcat gtctttcacg attttcagcg cgtagaatgc cgccattgtc 2750281 gggcctttgt catcaatggc gccccttgca taaatccgtc cgttgcggat ttcagctgaa 2750341 aatggatcac tcgtccaccc atctcccggc ggcacgacgt caacatggca aagtacgccg 2750401 ataatgtcat cgccctcccc ccattcaata tgacctgcga agccgtcaag attttttgtt 2750461 gtaaagcctt ctttttctcc aagctccagc aatgaagtca ggctggcatt taccccttct 2750521 ccaaacggtt taccgggtcc ggcggttgtt tcgtccatga cactgttgat tctcaaaaat 2750581 tcctgtgtat cacgaattaa atcctctttt tttctgatca cttcaacttc ccagttcata 2750641 atgatcccct ttccgcaaga aatgacttgc aaaaaccaaa taaaacgaat aatattaatg 2750701 gtgttttgtt aaaacgttcg taattggagg atactatgtt tcatctaaaa gagcagcaaa 2750761 catccataaa gcaagaaatc atagcagggc tgacgacctt tttcacaatg gtctatatcg 2750821 tcgtggtcaa tccggtcatt ctggctaacg ccggggttcc tttcgaccag gttttcaccg 2750881 caacgattat tgcctccatt gtcggaacgc tgtggatggc cctggcagca aattatccga 2750941 ttgctattgc gcccggcatg ggcttgaacg cttatttagc ctttcatgtc gtaagcgcaa 2751001 gcgatggcgg catcacgtac gcaacagctt tcagcgcagt atttacagca ggggttctct 2751061 tcattattct atcgttaacg cctttaagaa aacaacttat agaagcgatt ccaaacaatt 2751121 taaaatacgg gatcacaaca gggatcgggc tgtttattgc ttttatcggt ttgcgtcaag 2751181 cgggaattgt ggcagctgat gagtcaaacc tggtcactct cggcaatctg cattcacctg 2751241 gtgttatctt aacgctggtc ggccttttga tcagcgtggt cctgatggtg ctgaatgtaa 2751301 gcggcgcttt atttatcgga atggcagcta ccgctttgat cgcctttttc accggtcagc 2751361 tccatttttc aaagggattt atgtcgcttc ctcatttgcc ggaaggattg atgatctcaa 2751421 atccatttac cgcttttggc gatgtcattc atcacggcct gtacgctgtc gtcttttctt 2751481 ttctattagt caccattttt gatacgacag gcacgatgat cggagttgcc gagcaagccg 2751541 ggctgatgaa aaacaacaag ctgccgaacg tgcgaaaagc gctgcttgct gattcaaccg 2751601 cgacgacagt aggagctgtt ttcggcacaa gtccgacgac tgcatttatc gagtcttccg 2751661 ccggtgtcgc agccggggga agaacggggc ttacggcttt gactgtcgcg gtgatgtttg 2751721 cggcttcaat gtttttcagt ccgcttgtca gcgccttgtc aggtatagcc gccatcacct 2751781 cgcctgcttt gattatcgtc ggcagcctga tgatgggctc agtttccaat atgaactgga 2751841 aagagatgga cgaggcattt cctgcgtttc tcgtcattct agccatgcct ttgacctcga 2751901 gcatttctac aggaatcgcg cttggcttta tttcgtaccc aattgtaaaa gcggcgcggg 2751961 gaaaatggag agagattcat ccgctcgtca tcgttttcgc cattctgttt ttcatccagc 2752021 tgtttatttt ataaggatag accaaaaaac ccaaacgtcg ccgtttgggt tttttatgta 2752081 aacaataaag agacagcggc cgctaaaaaa caacaggcgg caaacgcata gtgcaggatg 2752141 ttgatacagc tttttctggc ccgataatat tcatcacttt ccttatcggt gccaattaaa 2752201 aaaggggcat ccatgacctt gtcaaaaata agcgtcagga tataacggca aacccctgtg 2752261 tataccagca gcgcaatcac cttcagccaa attggggaaa caaatatgag aacagtgaaa 2752321 gctgacagta gcatgtacat ctgccttgca tactcgccat tcctcagcat aactttaaaa 2752381 aacaactcct tatagcctgt gcagatcgtt cgtcttttaa atatcctttt tgaatttcgg 2752441 tataataatg gttttcttct catcctgtct tttacttttg gcattcccgc ctcctgactc 2752501 atcatcatca caagtcctgc aagggcaagc ctgctttttt tctcttcagt cacctcagct 2752561 tcaaaagccg tgaacgaggc tgtctttttc aaactgcgga taactgagaa aaacaaaaat 2752621 aaaatgccaa aaagcgcaag caagtgccgc tcagtaaaaa caatcaggat agcagaacca 2752681 gcaaaaagaa tagctctgac aagggtatcg ccaatccatc tcgaaatgga gcgcggcttt 2752741 ctgatcctgt cttgctttaa ggataaaaag aatatatgaa ggccaaacaa ataacacaat 2752801 agagcagtgc tttctgcgaa tgtgatgaga acagaatgac tgatcaaggg aaggacaatg 2752861 aaaaagagaa gcagccattt agccagcgtg gccagaaaag aatacaaaag cgcataccgt 2752921 ttgagctgat agatgatttc cttcttttgc agcaaaaaca ctttgtccgc ttccattaaa 2752981 aatgtacgaa tcgaacctgt aaacatgatc agcacacaca cagcatacag ccatctccat 2753041 tccgccactt cagaccactc ataaagaagg cctcttccgt tcatcaaatc aatatactga 2753101 tagatgacaa aagcaatcgc cggcaaaacg atatagagag cgactgtcca gtcaatgacc 2753161 gcatgcaaca ctttaaactg atacttataa tagtcaaaca gccttcgaaa aaagagcgta 2753221 cgcccgttca tagccgatca ccttgaactg ccttataaaa acagtcaagc aatgactgcc 2753281 cctctaatcc ggtcttgtcc tgaacatctt ttaacgtgcc ttggagaaat aatgaacctt 2753341 tctcaatcat ataaaaccgg tcacagattt tttccgcggt atcgagtaca tgcgtgcaca 2753401 taagaattcc ggctccacgt tctttttcag ccttaagcat gtccacaaag cgtttcgtcg 2753461 atatcggatc aaggccgata aacggttcat caatcacata catatccggc ttagagagaa 2753521 aggcctggat aagcattagt ttttgctgca tgcccttcga aaaggtgaca ggcagctcat 2753581 gtttgacatg atctagcgaa aacgtctgca gcaggctttg ggcccgatgc gcaaattcac 2753641 tctcttcaat gccgtgaagt gtgctgatca gatccaaatg ctcccacagc gtcagttctt 2753701 cgtagaagga cggatgctcc ggaatatatg caaatgaaca gtcgttccag gcaatatgcc 2753761 ctttaaaatc ttctgaaagg ccgagtatcg ccttgattgc ggtgcttttt cctgcgccgt 2753821 tagctccgat cagtccaacc agttcccctt ttctgacttc cagaaaaaca tcggtgagca 2753881 ctttttttcg gcttgtatac ccggcctgtt ctattgaagc ttcaagcaaa tttgtcaaaa 2753941 ctcactcacc tccaaaattt actacgaaat agaataaaaa aagtttcttt aaccataata 2754001 atattgagcc gaaatacata gtaatccaac aaggatggct gcccaacgcg aaattggaaa 2754061 aaattaatag gagttatccc tagattcatc actgcaatat cgtgtataat gagggcgaat 2754121 tattttaaca attacagatg tctgcctttg ttgctatttc gtacgcagtt gatagtcgtg 2754181 agttgtggtt agtcaagtcc atccgatctt atgataggga gtggtttttt gaaaccttca 2754241 acaaaccgta tgctaactcg aatcaaatca gtttacatgt ttattcaaga aaaaggtctt 2754301 gtgacaacac aggaactggt tgacgaattc ggcattacac ctagaacgat tcaaagagac 2754361 ttaaatgtgt tggcatataa tgatcttgtt catagtccaa gccgtggcaa gtgggagaca 2754421 acgagaaaga aagtaaagat tacctcataa attgaaaatt acatagggcc gcctgagagc 2754481 ggtccgatag ataacagggc gaagaaacta ctgagccttg tttttgtgtg cttataaata 2754541 aaaccccgca ttcggtatgc ggggtttttg tcatgcttgc ggctcattta gcaaatgaag 2754601 ctcttcctct gtcagctcac ggtattctcc gggtgccaga gcgggatcta gggaaacgcg 2754661 tcccatcgaa agccgcttca gataaaccac ttcattgccg actgcctttg ccatttgctt 2754721 gacctgatgg tattttcctt ctgtaattgt cagatatata acggtattgc cactgtcgtt 2754781 tgttttgatt tccgcttttg ccggctttgt tttatagccg ccctctatgt agacacccgt 2754841 ttccaaatcg gaaatgtctt cccgagaaat ctgtgatttt aaatggactt catacgtttt 2754901 tggaacatgc tttttaggag aaaggagccg atgtgcgagc tggccgtcat ttgtgagcag 2754961 caaaaagccc tctgtatctt tatcaagcct gccggctgga aatggctcaa atctcatctc 2755021 ctccggcgtc agcagatcga ccactgtttg ctgccggctg tcctcagtcg ccgacagcac 2755081 gccctgcggt ttattcatca taagataaat gaactctcga taatcaaccg gttccccgta 2755141 tacggtcacc tcctgcgtat caggatcaac gtgctccttt acatctttgg caggtttgcc 2755201 gtcgatcatc acggctccag ccttcacaac ggctttgact tcttttctgg aaccataccc 2755261 gctgttggca agcagcttat caagtctcat tcccaatctc tcctttataa aagaaagccc 2755321 gcagcatgcg agccctcagt ttcatcatat ctagttcatc agcctgcatg tctgcctttc 2755381 ctaaagaaac ctggcaaacg gcggcctaaa attttctgca aaaatcctaa tcggtagccg 2755441 caatacaggt agacagctcc gccaacagcg gccgcgatca ccacaacaat cgcagcttgc 2755501 atctggccat cctgatagga aataaagaag cctaataccc actgcacgat tttcacggca 2755561 atacccataa tggctgataa gaccagcatc aaaacagttc gtttaacaag tatcttatac 2755621 gaatagcctg catggcgctt aatcatgata aacccatata aaagggaagc gatatatcca 2755681 agcgccgtcg ctaaaatcgc tccgtcagcc tgcatcagct tgatcagcgg aacattcagc 2755741 acaagcttga tcacgacacc gatcacaagg ctgacaaccg caaatttttg cttattgatg 2755801 ccctgcagaa tagctgcgtt gactgtaaac aaagagaaca gaattgcgac aggcgaatac 2755861 caaagcaaaa tgtttgcccc cagttcagga tgaaggctct ctgacccgta aaagaacgta 2755921 tacgtcggtc ctgacaatag agagatcccg acaacagccg gaataattaa aaacaggatc 2755981 gtctgcatcg tttgattaat ctgctgattt aacagcttat agtttccgct tgtaaacgat 2756041 tcagtaatcg ttggaattaa tgtcagtcca aaagcagttg ctagggaaac cgggatcatc 2756101 acgagcttct gaacatacag ggttagaatc gcaagcatgt cctggctgat ggcttgatga 2756161 ccggcttcaa tcatcgcttt gttaaacgta tttgtatcaa tatagttata caaagggatg 2756221 gctagtccga caaaaacgta cggagcagca tagctgaaca gctcgaaaaa cattttcttg 2756281 tagcttaggt ttgctgtcgg acccgtattc ggcatcatcg ccagcaggct gcccttccgt 2756341 ttgttccaat aaatataaag cacgaccagc cctccgaagg caccgatcag cgctgcgaag 2756401 gttgcatagc ccacagcgat gacaaggccg ccgttgaaaa ccttcaaaat caagaatgtc 2756461 gcactcaata gaaagatgat gcggacaatc tgttcaacga cttgggaaac agctgtcgga 2756521 cccatcattt ggtgcccttg aaagaatccg cggacaaggc tcataatcgg tacgaccaaa 2756581 agcgctaagc tgaccatgcg gatgacataa acgacatgat caattgtcag gccgttatta 2756641 tccttgcctc ccagcgatat ttccgcaaac atcggagccg atagatacag aatgaaaaag 2756701 gctatcattc ctgtgactag cataaccgac atgcccgcct tgagcatttt cctgcttgtc 2756761 tcataatccc cttttgaatt atatttggaa acaaatttag aaacagcggc cggaaagccc 2756821 atcgtagcaa tattcaaaaa taaagtgtat tggttgtatc cgtattgaaa taatgcaccg 2756881 cctgtcgccc cgaccataat gctgaaggga attaaataga ccatccccag aatccgcgat 2756941 atatatgtac cgagcgttaa tacaaacgtg cctcttaaca gtttgcttga catgtttctt 2757001 catcaccatt ttctacgaag attcaacttt tctattttac cacaactggg catttagacg 2757061 gtaataaata caaaagcaat cctgtgaaca ttcatgtccg cggcaaaaga cgtttaagga 2757121 gcggctttct ttcgctataa tagtactgcg gacgggtgtc cgcacacgaa atgaaaagaa 2757181 agttgatgat aaagatgaaa caatatgacg taatcgtaat cggcggaggc ccttcaggct 2757241 tgatggctgc gattgcagca ggagaacagg gcgctggcgt gttgctgata gataaaggaa 2757301 ataaattagg acggaaactc gcgatttccg ggggcggccg ctgcaatgtg acgaaccgcc 2757361 ttcctgtgga agaaattatc aagcacatcc ccggcaacgg gcgtttttta tacagcgcgt 2757421 tttctgaatt taataatgag gacattatca agttttttga aaacctcggc attcaattga 2757481 aggaagagga tcacggccgg atgtttcctg tgaccgacaa agcccaaagt gtcgttgacg 2757541 cgctgttaaa caggctaaag cagctccgcg taacaatcag aacgaacgag aaaattaaat 2757601 ctgttttata tgaagatgga caggcagcag ggattgtgac gaataatggc gaaatgatcc 2757661 atagccaggc agtcattatt gctgtcggcg gtaaaagcgt gcctcatacc ggaagcacgg 2757721 gagacggcta tgaatgggct gaagccgcgg gccataccat aacagagctg tttccgacag 2757781 aggttcccgt cacttctggc gaaccgttca ttaagcaaaa aacacttcag ggcttatcac 2757841 taagagatgt agccgtcagt gtgttaaata aaaaaggcaa accgattatc acacataaaa 2757901 tggacatgct gtttacccat ttcggcctct caggacctgc cattctcaga tgcagccaat 2757961 ttgtcgtaaa agagctgaaa aaacagcctc aagtgccgat cagaatcgac ttgtatccgg 2758021 atatcaatga agaaacgctt ttccaaaaga tgtataaaga actgaaggaa gcaccgaaaa 2758081 aaaccattaa aaacgtgctg aagccttgga tgcaggagcg ctatctccta ttcctgctcg 2758141 aaaaaaacgg catctctccg aacgtatcgt tttctgagct gccgaaggat cctttcagac 2758201 aatttgtaag ggactgcaag cagtttactg tcctcgcaaa tggcacactg tcgcttgata 2758261 aggcatttgt cacgggaggc ggggtatctg taaaagaaat tgacccgaaa aagatggctt 2758321 ctaaaaaaat ggaggggctt tatttttgcg gtgaaattct ggatatccac ggctacacag 2758381 gcggatacaa tattacctcc gcccttgtca caggcaggct tgcagggcta aatgccgggc 2758441 aatacgcccg ttcttaatca ttactcttta aatctcttgc cgccaaactc acatttgaac 2758501 attccccgca ttcatgttag ggtgagactt gttttgtttc acctgattgc ggggtaattt 2758561 taagagagga atgagctgcc atcgtacgac catactaagc ctgcgagcaa gatataggcg 2758621 tacacaaaaa attagagggt gagaaatgtt gaaacatata tctagtgtat tttggattgt 2758681 gattgcaatc acagctgcag ctgtattatg gggtgttatt tctcctgaca gcctgcaaaa 2758741 tgtgtctcaa tcggcacaag catttattac cgattcattt ggttggtatt atcttttagt 2758801 tgtctctttg tttgtcgggt tttgtctctt tttgattttc agcccgatcg gaaaaatcaa 2758861 actcggaaag cctgatgaaa aaccggaatt cgggttatta tcatggtttg ccatgctgtt 2758921 cagcgcaggc atgggaatcg gcttagtatt ctacggtgcg gctgaaccga tcagccatta 2758981 cgcaattagc tctccatcag gtgaaacaga aaccccccaa gccttcagag atgcactccg 2759041 ctatacgttt ttccactggg gtttgcacgc ttgggccatt tatgccattg tggcattatg 2759101 cattgcctat ttccaattcc gcaaaggcgc acccgggtta atcagcagca cactgtcacc 2759161 gattctcggg gataaagtaa acggaccgat cggaaaggcc attgactgta ttgcagtttt 2759221 cgccactgtt gtcggggtgt caacaagtct tggtcttggc gcaacccaaa ttaacggcgg 2759281 tttgaattac ctgttcggca ttccgaatgc gtttatcgtc caattggttt taatcattat 2759341 tgtgacagtg ctctttttac tttctgcgtg gagcggactc ggaaaaggaa ttaagtattt 2759401 aagcaacaca aacatggtat tggccggatt gttaatgttg tttatgctcg ttgtcgggcc 2759461 tacagtgctg ataatgaact catttacaga ttctatcgga caatacattc aaaatatcgt 2759521 tcaaatgagc ttcagactga caccgaacga tcctgaaaaa cgcgaatgga ttaacagctg 2759581 gacgattttc tattgggcat ggtggatttc ctggtctcca tttgtcggca ttttcatcgc 2759641 ccgtgtatcc agaggccgga cgatccgcga atttttaatc ggcgtcttgg tgacaccttg 2759701 tattttgaca tttctatggt tctccatttt cggcgtatca gccatggatc tccagcaaaa 2759761 aggcgcgttc aatgtagcaa agctgtccac tgaaacgatg ctgttcggaa cacttgatca 2759821 ctatccgctg acaatggtga catcgatcct tgcattgatt ctgatcgcag tattctttat 2759881 cacgtcagct gattcagcta cattcgtgct gggcatgcag acgtcgtacg gttctttaaa 2759941 tccggcgaat tctgtgaaac tcagctgggg tatcattcag tccgccatgg cggctgtgct 2760001 cctatattcc ggagggcttg ccgctttgca gaacacagcg attctggcag cgctgccgtt 2760061 ttctatcgtt atcctgctga tgattgcctc tctctatcaa tcgctctcaa aagaaagaag 2760121 agagatcaaa aaagcggaga aactcgataa accaagaagt ccaagagtga aaaaagcata 2760181 ttaacaaaaa agatctttcc gcgcctgcgg aaagatcttt ttatttgcga tataaaataa 2760241 gggcggaaaa acagtaaagc tgctcgccgt ctgggtcgca cgccgccgaa accgtatatt 2760301 tgatatctat cagctgctcc tccgatatcc cttttaaaaa tgaattgatt tccgtttgta 2760361 agtctttttc atgctcttca tcaaataccg ctaccttcag cattttatcc gctctccttt 2760421 ctctatcaat ctattccgtt tggaacagcg ttatgataga gaaatgatga ttatctcgtt 2760481 tccggataaa aagctttccg tatatgggat ttcctctgtg gctcgccgcc gtgctgctcc 2760541 actttcagca gcacggcata aacaatgcgc atatggcagt agctgataag gctgacgctg 2760601 aaaaaaggga caatgcccgg caggtacgca agcaagaaaa agagagcaac agtcagcgca 2760661 agcatagtaa gcgtatattg caaatacgcc acactgagca agagcgaaaa tttcacatac 2760721 agacgttttt tccagtcaaa atggacaagc agcggaaaca cataaaaaag catggatacg 2760781 aacaaaaagc caaatatcat aatggcgaag cgcaggatgt gcagaaggaa atgacttgga 2760841 taaattaagg ccaaatcaat ataaatgatc actccgatga gcgccagtac agcgccgagc 2760901 agatttgaac gaaaaaattc acccttgtat tcctgccaaa acgttttgag caccggaacg 2760961 ttgtcctgcc cctggatcca cttccgcatg acagcgaata aagccgcggt cgcgggcatg 2761021 atgccaaaca cgccgagacc gagcaacgta aaaaacagcc acagcaagtt tgtatacgca 2761081 aatctcataa tccattcgca aaaacgcagc atccgtccca gtgagccatc atgttccatg 2761141 gcgccccctc cttttttgca ttatacattc tgcatctgaa aaagctcttt catgccgatc 2761201 ggcttctttt cggcaaccga gcgccacatt ccctcaccaa ccgcgatgga gtaggctcca 2761261 gcttcagccc cggctaaaat atcatagcgg cgcagcgggt ctttccctaa aaaaagatcc 2761321 tcaagcaaaa gcggatcacc tccgccatgc cccccttcat ttttgaccac ttgtatcgtc 2761381 tgctttgatt caaaaagcgg atagtattcg attgtctgct caggaaaagc aaacggaatt 2761441 ctggaaggtt cgtgaaattc atttgattca atacgtcctt ttgtgccgtt gatcgtcagc 2761501 cggtagcctt catacggggc cgaaaaaata atcgagtagc ttaacagtgc gccgccatca 2761561 tatttgactg ccgccacgta cgtatcctcg atgtcaattt cctcgtcaaa aatacacgcg 2761621 tcaggcctgt atgcagtata taagctggac tggtctcctg cttcaagatg atcatccttt 2761681 atagaagctt tagaggaacg gggatgccac cttgaatagt agtggcattt ttctttaaca 2761741 cggcacgtcc cgcaaaaacg cccgtcttct tccggcaagg ggttccactc actgtccggc 2761801 ccatagtaat tcaaggcgcc ataagcaaat acctcttccg gattttgccc gagccaccaa 2761861 ttgacgagat cgaagtgatg tgttgattta tggacagaaa gaccgccgga aaactgtctc 2761921 gacctgttcc agcgtttaaa atagctggcg ccatgatacg tatcaatata ccaatttaaa 2761981 tcaacagaag tgaccctgcc tatttttccg tccagaatca tttcttttat tttccgatga 2762041 aacgggctgt agcgatagtt aaacgcgacg gtgacttttc cttcgctttt ggcctccgct 2762101 tcaagcaccc gattcgcatc ctgcactgtt gtcaccattg gtttttcagt aatcacatct 2762161 gtattccact gaaggctttt tacaatatat gcgacatgcg tatcgtccct gcctgccaca 2762221 atgacgatat caggctttga gacgcgcatc atctcgtcaa aagcatcttc gctaaactca 2762281 ggcacgtggg ccagctcggg aaatttcttc ttgcaaacgg caaaacgttt cggatcggca 2762341 tccagcaatc ccgtaatctc ataatgagtt gaaaaccgct ccatcagtgg tttgataaac 2762401 atactgaatg ctctgctgct caatccgcaa aagacgatgt tcttcaatat cctcacctct 2762461 atcgggcttc agttagttga gaaatcagct gcagcgcttc ctctgttttt tcagcataca 2762521 cagggataaa cgccgccata tcgcgattca attgaaaaga atagccgttc agctgttttt 2762581 tccctttttc gatctgaacg gcatagatcg ttttttctcc tgttttttta ttaacagttg 2762641 tataaggaga tgttttttca ggaggcaatc cgtttaacgg ctgaaaattt tccggatcat 2762701 cgtaagcttg aaacatgtct tcaggcacga tgaaaacatc tccctcatgg gcggtaattt 2762761 cagtcagcag tttttcctga aaagctggaa agatatcgac cttcccggca ttctgctcgg 2762821 cggccttttt tattttttcc tgtacgccag cctgcatatc agaaaagaga atgacatgca 2762881 ttccgtccgg cctgcttgag catgatgcca aaaagagcac tgagacgatc acacacaaag 2762941 ccgtacgtat cctttttgtc atttccccgc tgacctaaaa agaggctcca gctctgtcat 2763001 agctaaaata aacgcgccgg ctccgtgcag atcgtttgtg cttctttcgc ggctgacata 2763061 atagtcatag aaaccggctg acgttccgac acatatgtct ttgacgagaa acgctccgtc 2763121 ttctgatgtt tcggttttat gctgaatcaa gccttgatac gcttttagca gtgttgtttc 2763181 gtaagctctg tctagatagc ctttattgat tccttttgcg attgcgtaca tgtacagaca 2763241 ggatcctgag ctttccagcc agttatcaga cctgtctccc ttatcaacga tctggtacca 2763301 taaccccgtc tctttgtctt gatagcgaca gatgctttta atcatgtcct gcagcgtgtt 2763361 tttccacaca tgacggttcg gatgcttctt cggcagctct tcaatcatgt cagcaagaga 2763421 catgacgtac cagccgatgg aacgtgccca aaattccggt gaacagcctg tctcttcatt 2763481 ggcccaaggc atttttttcg cttcatccca ggcgtgataa aaaagtccgg tttttgcatc 2763541 cttcgtatgc tttctcatca atgactcctg aagcacaacc tgatcaaaca gctccgtctc 2763601 ctgcttcaga ttggcatatt tcagtgcaaa cggccccccc atgtataagc cgtcaagcca 2763661 catttggtaa ggataaccgt ctttgtgcca aaaaccgccc tcagacgtcc ggttcagtgt 2763721 tccatataag ctgcgcagcc tttttgccgc tttgacatac cgttcatcct tcgtctgctc 2763781 gtataatgga aaaagaatga gacctgcttg aatggcgtcc agttcatctc ttctaaataa 2763841 tagattgcca ttatcatcga ttaagagatc tgcataagcc ttcgcatact caaaataccg 2763901 cttttccccg gttgcttccc acagccgcaa tacaccgcat aagaaaacac cctgatggta 2763961 gtgccagcgg tttgcaggtg gcagctcctc gactgtgtac gtgttcataa tggtgtttgc 2764021 caatgcctcc gcgtacgtaa gaggcgattt tacagcgatt gattgatcca ttgatcccat 2764081 ccctttccta ataaattcct tcctcgccaa atttcttcgc caaacgattc gctagcatga 2764141 ccaaaatcag cccgaccgcc gctttaaata cgccgactgc tgtactgtag ctgaattggc 2764201 cctgtttcag ccctgcagta taaacatacg tatcaaaaat ttccgccact tccctgttag 2764261 tcgcatttaa cagcaaatac acatgctcga agccaagctc cagcgtgtct ccgattttca 2764321 aaatcagcaa aacgacgata acgcttttaa tggcgggcag cgtaatatgc cacatttgcc 2764381 gcagccgtcc cgctccgtcc attttcgccg cttcatacag ctgggggtca accgctgtaa 2764441 tggccgccag ataaatgatc gtcgaccagc ccgcttccct ccagataacc tgcagaatat 2764501 acaggggccg gaaccattct tcgttcagca gaaaattgat tttttcaccg ccaaaaaaca 2764561 caatcagttc attaatcaag cctccgtcta ccgttaaaag cacaaacgaa agcgatacaa 2764621 caatgaccca agacataaaa tgcgggatat aaatcagcgt ctgaacaaat tttttaaaga 2764681 gagcaatccg cacttcgttc aatagaagcg ccagcagtat cggcaccggg aaaaatatgg 2764741 ccaggttcaa agcaaataac acgagcgtgt tttttaacaa gagaaaaaat gtaggctcag 2764801 taaacagcct gataaaatgc ttcagcccca cccactcact gcccaaaatg ccgaggaacg 2764861 gctgataatc ctgaaacgca atcacaattc cccacatcgg gacatactta aaaagcaaaa 2764921 aataaataca ccccggcaaa atcatcaagt acaaatattt ttgttgaatc agcttgatta 2764981 gtaagcgctt tcttttttct tttttaaaaa tgactgcatc aacagccggc gcttgcgctt 2765041 ctgctgtttt cattttttcc tagcctcctt tcacggattc ttgcattcac tgtagcgcag 2765101 caggcaaaag tccgtctaca atcatatgat cacatcctgt tttatccctt tataatcaag 2765161 ggttcagccg gtccacctga aaaaaagaca ccgatattag aaaatgatta ttgacaatat 2765221 ctatcaatct ttggattaat tgtattaagg tgaagtggat gttatgaaat ggggggtttt 2765281 atgaaaagaa gccaatacaa gttttactac aaactgatca cgtttttctg cctgctcagc 2765341 accattccgg ttattttggt cggattattt tcgtacgagc actctcagaa aacggctatt 2765401 tccaacgttt cggaggaaaa attcgacaca ctccagcaga cccagcaaag catcgagcat 2765461 atattgaaaa ccgtcgatca ctctttaacc cactatgtga gttcgccgcc tctccttcgc 2765521 acattgtccg agcctttgca ctcagaccaa tttcaaatct ataaccaagt gaaccaagag 2765581 ctcaattatc tgcaaagctt tgataccgat ctgtccaaca tgacgttagt cagttatacg 2765641 aaaaaatggt acatgaacaa ttccggtttg taccgtttga atacagacac tcttcatgaa 2765701 gcagcctcag cgtacacgaa acaaaaagcg agccgctcct attggacgct tgaggaaaac 2765761 aatcatttga tttcaaccaa agaaggcaca gcagaaaact gccgctacaa tatcaattta 2765821 attaagcagc ttcctttgaa cagcacaaat acaaagggat tggccgccgc aagcatcccg 2765881 agctgttcgc ttgtcaaaaa tatgcccggc tattcaaacg ccaacaacct gtttatcatc 2765941 gatgaaaaag gcctcatcat ccttcataac aatatgtctg acgttggtga atctcttcat 2766001 aacgacggct ttgtccaaaa agtgctggcg caaacggcca atagcggaca gtttgaaaca 2766061 gtgattgacc ggattcatta taaagtcacc tatcaaaaat ctgactataa tgcatggact 2766121 tatttttctc tcgtttccct gcctgagtta aaaaaagaag ccaaatcaat cggctggatc 2766181 acttttgcag tatgcctcat tttgttaacg ctttcattgc tgttctcttg gcttggctcc 2766241 cgccattttt acaagccgat cagggtgctt tacgaatcat tcgcaagaca tggagccata 2766301 caagagaaac aacagcctcc tcaaaatgaa tttgagttaa ttgaacagag ctttaagcag 2766361 ctgaaggaca gaaatgacga ccttgaagaa acgatgaagc agcaggccac tcatctgcag 2766421 caatatttta tggtcaggct tatgcttgga aaactgacgg atgaggaggt tgataaccgt 2766481 tttgaaagcc tcggcttaaa gcaaaattgg cggcaccttg ccctgcttgt gctccaaatt 2766541 gacacactga atcatacgcc ttatgagaaa aaagatatgg atctgctttt gtttgccgtc 2766601 aacagcctga ttgagcgcaa catcccgacg gacaaacatc ttgcccccgc cgtagttgac 2766661 aaacagcagg cgacgatttt gatcaatcaa agcgggacaa aggaagaatt catggctgag 2766721 ctgaatgaga ctgcaaggat gattcaggaa aaagcggaag ctgagctgca gctgtctgtc 2766781 agcatcggca tcagccagcc gtttgatgtg ctgacaaaag cgaaaacagc ctatgcggaa 2766841 ggctcagaag cgttgaaata tcggctgaaa gcggaaaaca agtcgatcat cttttacgaa 2766901 gaccttgacc agaaaaaaac cttcaaaacc cattttccaa agcagcttca gcatgagctg 2766961 ttcgatgctg tcaaagcagg agacaaggag aaagcggata aatgcctgca cgcgatttta 2767021 caagccattt tcacccagaa caccaacccg tatcaatttc aaatcgccat cgcccgtttt 2767081 ttgaaccatg tgattgagct gatgcatgtg cttgggatcg aattgtttga gcttgaagaa 2767141 aacaaaatgc tgtatgacca aatttttgag ctgaaaacgt tcgaggatac cgaaaactgg 2767201 ctaaagaatg agtttattga tccgatgaca gacaaagtga acgcccgcgc ggatgcccag 2767261 tacaaaaata tttccgacaa catcattcat atcatccatc atgagtttga atccgaattg 2767321 acactggacg aaatcgcacg caggctgcat tacaacccaa attatttaag cagtattttc 2767381 aaaaaagaaa tgggaatttc attcagcgag tatgtctcaa gctaccgaca ccatatggcg 2767441 aaaagctggc ttgccgaaac cgacatggcg gtcaaggaca ttgccgaaaa gctgaaatat 2767501 aaaaactccc aaaacttcat cagatcattt aagaagctgg aagggattac accgggaaac 2767561 taccgccagc aaaaaagaag catgtaaaaa acccaaaacc gcttgcgcgt tttgggtttt 2767621 tccaatgtta ttttgcttgt ttaaacgctt cttcgtattc ctgaataatt tgttttcctc 2767681 cgcttgactc ccatttttcc acttctttat cgaactggct ttctgtgatg tctccaatca 2767741 tatatttgta ggtcgcgtca tcaatgattt tcttcagttc gtcaccccgt tccgactccg 2767801 atgcggaata caggctttca gccgggtttg agacgataat cttttcattg tcctcggtca 2767861 gctcctcgta cgccgtccga agcggatctc cagtgttttt taagtaggct ttatcaatgg 2767921 caattaaagc ggacagcggc tgaatatcag tctgccagtc ttttacctgg ctttctttgc 2767981 gtgtaaacgt tttgtcctca cctttgttgt aatgaacgcc gtcaatgcca taagtcatca 2768041 ggctatagac atcttcttcg gcaattcggt caaaaaacgc caagatccgt ttaagctcag 2768101 cttccgtttt cacactcgtt ttcgggaaag caaacacgcc gttatggcct cctgatgccc 2768161 atacccgctc tttcccatct gggcctttta tgcggttgat gatctcgagc ttcatcgatt 2768221 tatcagaggc atggtcgcgc agattgaccg catctaccat attgccaata taaattccgg 2768281 cttttccttg agaaaacagc tcttgctgct gggttttgct tgtgacggga aaatccttat 2768341 tcatataccc gttatcacgc agctttttca tatagttcat cgtgtctttg tattcctgtg 2768401 tcatgaaatc aggcgtgaat ttgccgcccg attccttcca atctgtcggc atgccttcat 2768461 acgagccaat cgttttaaac gcgccgtaaa tcaagtcatt acggtctgcc agcccgaatg 2768521 tatcatcttt cccatccttg tccgggtcgt cctccgtaaa tgctttggcc acttcataaa 2768581 gctcatccaa cgttttcggg gttttcaaat ttaaattgtc cagccagtcc ttccgaatga 2768641 cgatcccctg tctggaaagc gggcgctctc tgtatatccc gtagagcttg ccgtcaattg 2768701 tcacattttt attaatgagt ttgttcattt tgtttaagtt gggataatcc ttgatataat 2768761 cgccgatttc ccaaaacatt cctgaccgaa aggcattcat gactgacgaa tttttaatat 2768821 cctggatggt cacgatttgc ggaagattgc cggctgcaag cgctgcattc agcctgtctt 2768881 ctttcaccgc gtctggaacc caggtgatgt cgagttctgt atttgtcagc ttttcaattt 2768941 ctttaatcgc cctgtctttc ggcggctgct ggtgatacaa aatcgccatc caagacagct 2769001 ttacctttga atctgggcca gctttgcctt cagccgaaga ctgatcagtt cctttacagc 2769061 ccgccagcac tccgccgagt gccagtacaa gcacaatcaa aagcaccctc catttgtttc 2769121 ccatcgtacc cctccgtttc atatttcttt atcctttgac agatcccagc aaagctcctt 2769181 ttgcaaaatg cttttgtata aacggataga caagcagaac agggatggtc gccaccacta 2769241 tgaccgccat tttaatggtt tgctcaggcg gcgggctgcc cgaccccatt tcagacatat 2769301 ccccctgcat accgcttgat acaatgacga tttggcgcag aagcacctga attggccatt 2769361 ttgctgaatc atttaagtac aagatcgctg tcatatacgt gttccaatac gtgaccgcat 2769421 aaaatagtga aatcgttgcg atcgcaggaa gagacagcgg cagcacaatt ttaaagaata 2769481 tgcccagatc attgcacccg tcaattttcg cggactcttc caggcttgac gggatatttt 2769541 gaaagaagtt tttcagaatg atcaggttaa aggcattaat ggctgtcggc aaaataagcg 2769601 cccagtaaga atcgagcaat ccaagcgatt tgaccacaag gaaagtcgga atcatgccgc 2769661 cgctaaacag catcgtaaat acgacgagaa acatgagcgg ctgccggccg attaaatcac 2769721 ggcgggataa cccgtaagcc atcagtgacg aaagaaacat gctgaccgca gtgcctatca 2769781 ctgtcacaaa cacagaaaca agcaaactct tataaataat atctgttgaa aaaatgtagc 2769841 gataagcatc tagcgaaaaa gtggtcggta ttaaaataaa ttttttcgac acgacttctt 2769901 ctactgtggc aaaggatgct gcgataacat gaatgaacgg aagtacgcat attaaagcga 2769961 acatcagcaa gaaaccataa atcaacatat caaacagacg gtttttcagt gaatgtgcga 2770021 tagctcccac ctccctttgt aagcgttatc atatttttgg aaaccgagct cagcatgtga 2770081 cgatatcgtg tctaaaatgt agcaaatctg tgattgccat gtctataatc atttgaacag 2770141 tgtccccggc cgggcggggg ctgccgcgaa ttgagaccga taacaaaaga aaaagagcat 2770201 aatcttagaa aatgattatg ctccgttctc ctcctcgttc agaagttcag ccgtattgat 2770261 ttgtggcgaa aacccaagtt cattcacggc agattcaatg gaccatggcc ggcccggatt 2770321 atcagagacg gcgtaataag tgccataccg gatgttggtc tcaatggcgg ctttgaaaat 2770381 cgacagcaga tcggggtgag aaagcagtgt ctttttcgtc cgttcttttt catgcagcgt 2770441 atccatttca tctgtcacga ctgttccgat tcgaaggttg attactgata gcttattttc 2770501 caaataaaac aaatggccga tctgttcaga ggtcagcttt aatacaccgt acaagttttt 2770561 tgacagcgga taatcgcttg ttgtgatttc ccgtcctaag agcgagcgcc cgtctttttc 2770621 atatacatct gtgacatgat tgctgctggc gaacacgagc ttttgaatgc cgagctccgc 2770681 tgccgcacgg cacagataat agcttgccct atagaaaaca tccgtcattt tttcaaactc 2770741 agcgatgtcc ataatatcgt atttgatttt cacagcgagt aaattcaaga tggcatcggt 2770801 atcttttgga atcttcttca acagctcctc ataatttgcc gcgtcagcct gaatggaaga 2770861 ggctttgcca tcgaaatgat ctttatcaag cacagtcact tcatagtctg aaataagccc 2770921 ttcagcaagc agtctcccaa tcacaccatt tccgccggcg atcagcactt ttttcacgat 2770981 gttcactccc cttttttata gattgcccat tttcggcggg gctgacactt ttttggcact 2771041 cacattctta ggcttattca aaagtcaccg gcagctcctc aagcgcccga aatccaaaaa 2771101 gcggccgata ccgccattca aaatccgcaa gattaaggct gggcattcgc tgcagaagag 2771161 tgttaatcgc aatttgcgct tctaatcgtg ccagcgagga ccctaagcaa acatgatggc 2771221 catgcccgaa tgaaagatgc ggattaggac ttctcgtaat atcgaagaca tcggggttcg 2771281 tgaatatgct agggtctcga ttagccgctc ctaacaaaag atagacttgt tctccttgac 2771341 ggatcgtcac cccgcagatg tcaatatcct ctgacgcaac tctggctgtc atttgcgtgg 2771401 ggctttcata gcgtaaacat tcctcgactg cggtaccaat aagatctgga ttttctctca 2771461 gtttcaaaag ctgttctgga tgctgcagca gacaaaggac tgaattgctg atgagattga 2771521 ccgttgtctc atgtccggcg atcgccagca atatgcacgt agatgccgcc tcctcttccg 2771581 tcagcttatc cttttctctc cccttcaaga gcatgctgat catatcctgt tgagggtggc 2771641 gttttctctt ttgaatcagc tctttgaaat atgccatagc ctgcacagcc ataatattgc 2771701 cctctgttaa tgcctttctt gagcgggtaa aatcaatcgt ttgaatgaga ctcgcagccc 2771761 actcctttaa ttgctcccta tcttcctccg gtacacctat aatgttagct atgacaaaac 2771821 ttgctaaagg aaaagcaaag tccgaaatga cctccatctt ttttttacct tgcacttgat 2771881 caagcaaatg atggacagtt tcaatgatat acggctgata actctctgtc gttctcggcg 2771941 taaacgctcc gctggcaagc gtccgcaatc gtctatgatc aggctggttc tgaaacagca 2772001 tcatttgatt ttgcacatgt gaaaggtcct gatatttggt tgagctctca ggcagcgggg 2772061 tgcggacttt gaatctcgca tctttcaaaa tagcagccgt ttcttcatat cctgtgacat 2772121 accagcccgg gtattttaag aaactccctt tatagatagg atgaacagct cgcaatgtgt 2772181 cgtaaaaaga atatgggttt ttcaaaaact cagaagatgc agttgacgat gcaattgtca 2772241 cgtgattttc tcctttctgt tcaaaaataa aaacaatcga catcataccg attgctttta 2772301 ttgattcttt cagcttttcg cacttaaact agccttcatt tcttcgactg attcaacttc 2772361 aaagcctaaa tcactcagca ttttatgatc ctccgtctcc tcttgcccgg cagttgttaa 2772421 gtagtctccg acaaaaatgg agtttgcggc gtaaagccct aatggctgca atgtgcggag 2772481 attgacctct cttcctccgg aaatgcgaat ttcttttgat ggattgataa aacggaacag 2772541 cgccagcact tttaaacaat acagcgggtt taattcgttg acgccttcta acggcgtgcc 2772601 atcaattgca tgcaaaaaat tcacaggaat ggaatccgcg tcaagagcct tcaagctttt 2772661 ggcgatgtca atgacatcct gtttcgtctc cttcatcccg ataatggcgc ctgaacacgg 2772721 agacagcccc gattcttttg cgatttcaac cgtattgact ctgtcatcgt atgtatgtga 2772781 ggttgtgatg tttgaatggt ttctctgtga cgtattcaaa ttatgattat agcggtctac 2772841 tcctgcatct ttgagccgct tcgcctgctc tggcttcaac agtccaagac atgcacaaat 2772901 cttcagtcca tacgtctctt taatttcctg aaccgcatct acgacctgat ccacttctct 2772961 gttagacgga cctctgccgc ttgccacgat acaatatgtg ccgatattca gatcgtgcgc 2773021 ccgcttcgcg ccttcaagca gcgtttcctt attcaccatc cggtaagact caatcggcgc 2773081 tttcgaaatc gcagactgtg aacaatagcc gcagttttcc gggcagagcc cggatttcgc 2773141 attcataatc atattgagct ttactttttt tccgtaaaag tgttttctga tgtgaaaagc 2773201 cccgtgcatt aatagcaaaa tatcttcatc aggacaatgt aatattgaaa gcgcctcttc 2773261 gtcagtcact tctgctccag ccagcacccg gtctgcgagt tccatccatt gattcattct 2773321 cataccccca cttgattcat cagtaatgat agattgatat ggtcttttac catatgtaga 2773381 accgtttctt tcgtcacgtt ggcaagcttt ggcgtaaccc ctaaaatcgg cacaccgcat 2773441 aagcgctcaa tcatctcagg attggttttt tcatcttcat caggagagtc actgattcca 2773501 ttgatgataa ttccggcgat tggaagcccc atgctttctg catatttgac agttaaaaag 2773561 gtatgattaa tggttccaag gcgaggacgc gccacaataa tcatgggaag ctgcaacgct 2773621 tttatgacat gactgaccaa atagtcctct cccaatggca cagaaatacc gcctgcacct 2773681 tctacgatga agcattcatg tttttctcta atccgccccc aatggcttaa aacctcttcc 2773741 atggtgacag tctttccctc aagtttccct gcaacgtatg gtgcaagcgg cgccttgaag 2773801 gcaaaaggcg taatgtcttc atgagaaaga ctggtctgcg acatatcttt cagcaaactt 2773861 gtatcactat ctggatgatg gcgcgatatc ccgcttaaaa atggtttata caccccgaca 2773921 tgtctattat tgtctttcaa taaggcagca agaccgctgg atataaccgt tttccctact 2773981 tctgtatcag ttcccgtcac aaaaaaaccc ctcaaatgat gtgcagctcc tttccgattg 2774041 aatgaaatgt ttgcagcaaa tgatcaatat cacccatact gtggtcagac gtgattgtaa 2774101 ttcgaatccg gctttcaccc ggcgcaacgg ttggcggccg aatggcagga gcataaattc 2774161 ccttgccctg cagtttttca gcaaatagga ccgttttatg ggcatcgcca atgactacag 2774221 gaataatcgg tgtgtgatct cctttcacca cataacccat attcttcaga ctggttctga 2774281 tcatgctgat ataagaaaat aaaagctgtc gtttttccct gctggcttca atgatgttga 2774341 aagcctcgtg agcagccgca cagctggctg gcggaatagc ggtttgaaag ataaatgttc 2774401 tggcatggtt cagcaaaaag tcgatgaaga ccgctgatcc tgccgcaaaa cctccttccg 2774461 cgccaacagc tttgcttaag gtgccgataa caatgtcggg acaaacacca aagtattcac 2774521 tcgttccttg tcccgaatcg cccaaaactc ctgttgcgtg ggcatcatca acgaccacga 2774581 aggcatgata gcgtttcgca agtgagatga tctgatcaag aggggcgatt gtgccatcca 2774641 tgctgaatac tccgtctgtt acgataaaac ggcgctgata acgctgtgtt tcattcagct 2774701 tgttttcaag atcattcata tcaatatgcc gataaacaac tgtatcagcc ttagaaagtc 2774761 ggcagccgtc gatcatactt gcatgattga gctggtcact taaaatgaca tcttcctttt 2774821 ctggcaagga tgaaaggaca ccgacattgg ccaagtaacc gctcgaaaac agcagggccg 2774881 cttctgtcag tttaaagctg gcaatcttct tttctagctt ttcatgccag accgaattgc 2774941 ctgtcgttaa acgtgaaccg ctgcttcctg tcccaaattg ctgcaatgct gtttgggctg 2775001 catcgatcaa acgtctatcg cttgcgagcc ctaaataatt gtttgaggac cagaccgttt 2775061 gattttcgcc atcaatattc ctctctggaa ccggcgctcc atccattgac cgcaggttac 2775121 gatgtacgcc ggcttctttc attctgtcta accgctcgtt taaccaggaa tcaatcttca 2775181 aggctcgtaa cctcgtggat cgcttgtttc ataatggcaa ccatttccga gagctcttca 2775241 gctgtgctgg caagaggagg aagaaatgca atcacgtccc caagcggtct tgtcagcatt 2775301 cctaactctc tcatttttaa ggaaactttg tatccaatcc gccgatcagc cgggtaaggt 2775361 tctttagttt cctttgatcg tacaagctct gcaccgcaca taaagccaag ctgccgaata 2775421 tccccaacat gaggaagagc gtgcagatct tgaagaagaa aatggagctt tttacttttt 2775481 tccgctactt gttccacaat gttttcagat tcaaataatg ccagattttc aagcgcaacc 2775541 gcacagccaa gctgattgcc tgtataggaa tggccatgga aaaaggtttt taggttttca 2775601 taatcatcat agaatgcctt atagatgtct tcagtggcaa acgtaacggc aattggcaaa 2775661 tagcctcctg taatgccttt accggcagcc atcagatcag gctggacatt ctcgtgctcg 2775721 cacgcaaaca tttttcctgt acggccaaag cctgtagcga cttcatcaac gatcattaag 2775781 acatcgtatg ttgtacatag ctcgcgcacg cctgccaaat atccttccgg catcacgatc 2775841 ataccggacg cgccttgtac cattgattca atggaaagcg cggcaatttc ctcatgatgt 2775901 tcctcaagca gctgtgcaag ctctcggagg cactgatcac ggcactcatc aggatcaccg 2775961 ctttcagaac gatacacata aggaatcggg gccttgtaac tctcgaacat caacgggccg 2776021 tatacgtggt gaaaaagctc aattgaaccg acactgacgg cgccaatcgt atcaccgtga 2776081 tacccgtttt tcattgcgat gaatttttgt ttctcgggct tcccgatgtt cttccaatac 2776141 tgaaacgcca tttttagggc tatttccatc gcctctgcgc cgctgtctga ataaaagacc 2776201 cgcgtgagct tttttgggct gatgtcgatt aatgtttcgg caagctgggt tgctggaaca 2776261 ttggtcatgc ccaataacgt ggagtgcgca atttttccga gctgtttttt tatggcgtca 2776321 tctagttctt ttttgcggtg tccgtggaca ttaagccaaa ccgatgaaaa accgtcatag 2776381 tattccttgc cgtttatgtc tttgactttg attccagtcc cgctttcgat gattaagggg 2776441 ttttcatcat aatctttcat ttgggtaaat ggcagccaga ggtgcttttt acttttttct 2776501 atcaaatcat gagtcatgat cttcctccca ctctattaaa ataggctgct tctccaggtc 2776561 atgtatgtac gtgtttacat cattggatcc atcaataaaa aagactcggc agccctcttc 2776621 agtcccgtat tctttcattg ctgtaatacg ctgatagccc attttcttac ccgcaacata 2776681 gcctgttatg taatccggat cgtccgacca gcataattct gcaacgactg ccgggtgccg 2776741 gcttaccttt gaagcgagcg caagggcctc ttttattctt gaatgagctg gcacgtgact 2776801 gtgaagcgcc catttttcaa aattagcgtc cggccaatcc attctggaga cccgcacccc 2776861 tttttctttt gtttgatcca ttcgcttgcc tgtatgaata tcaaacaaca ccgcacccct 2776921 gacatctgac cattcaggga tttgttcata tgctttttca atcacgtctc gtgaaacgcc 2776981 ttctttttcc aataacaatc gggcaagctt ttgtccttct tccgggcagc tcacttcatt 2777041 cgtatgcaca ggcaatggct gaatggtttt tatcgattca tgtacctctt caaattgaat 2777101 ttgcataaaa tcaggttttc ctcttgaatg ggataaccct ttttctaata aagcattgac 2777161 tgtatgcttc atctcatgga aaggaataag ccgttctccg ccggatatat gctttccgcc 2777221 gtcttcatga gatccattca ttgaagccct cattctgaca ctataaaaag tttcttcttg 2777281 catcatttct cgccctttca ctgataactg aagaacgtgt agcgcttctc acctaaattg 2777341 ttaaccaatt atattcaaag gttaacaatt agaatatatt attctctcct gtttctgtca 2777401 atagaagaaa ggatcgattt atggcagttg gttaaaagga aacaaaaaga ccgttttcac 2777461 acaaaacggt ctttttcgat ttctttttac agtcacagcc acttttgcaa aaaccggaca 2777521 gcttcatgcc ttataactgc tgtttcgaaa tgtcccgaag cagaacggac cactcggtag 2777581 caatcagcag ctccctgtcc agcatagaca gctgtcaatt ctttttcgat tttgtccacg 2777641 ccctcagccg gcgttaaccg atcgtgtaca ccaacaagac taaggtgcgg gcgcggcgcg 2777701 atcaggcttt ggatctccga tgcggaaaaa tgctttgcaa gcgatgggac gtaataataa 2777761 aagccgtgcc tgtcaagatt ctgtgttttg atcagcacgt gatgatccac ctggctgcac 2777821 aaatccacac acaccttaat ccggtcatcg agcgccgctg tccaccacgc catcaaacct 2777881 cccatagaca tgccgatggt tccgatcctg tcaggctgaa catcagagcg tgactgcata 2777941 tagtctaacg cacttaaact gtcataaatc atcatccccc acatcacttt tccggtgaga 2778001 agcatttctt taaatatctc gctttccgct tttccccgcc gatctccaaa cccccaatga 2778061 tcaatcgcaa gaacgccgta tccgagtgaa gtaagctcat cagaaaaaga aggcgttttc 2778121 aaataatccg ctccctcaat cagctcactt tttcccctat catactggcc tccatgcgaa 2778181 tgctgaaaca atacggctgg gcacggtcct tctgttttct tcggcttcac aaaataagcg 2778241 ggcgcctttt catgtccatt taaatcgagc aggagcgttt caacgatatt ttcttctctt 2778301 tcttcaatac gtaatgtctc aacactgatt ggcctccgat caggcaaatc accaagcaat 2778361 cgaaacagtt gctttcttct ttcggctctc atcccatcac ccttccttat tcgcttactt 2778421 cacatttacg agacagatct gggttcccct ttatttttcc aacataaatc acatcattta 2778481 ctaaatattt agtaaatatt atggaatatt tcgaaaacaa ttattgtaac cgcttacttt 2778541 tatatgataa tatcaattta tcaaaaacag atgagttaat attttactaa atagatgaga 2778601 gggataccca tggttcgtat taaagatatc gccttgaaag ctaaagtttc cagcgcaact 2778661 gtgtccagaa ttttaaatga agatgagtcg ctttctgttg cgggcgaaac gagacaaaga 2778721 gtcatcaaca tcgctgaaga gcttggttat caaaccgttg ccaaacgccg aaaatcccgc 2778781 gggcaaaaac agcgggctca gccgctgatc ggtgtgctga gctgtctgtc ccctgatcag 2778841 gaaaggcagg acccttattt ttcttccatt cggaaaggga ttgaaaagga atgctttgaa 2778901 caggaaattt tcattacaaa ttcgattcat ctcggctcct ttcaggaaca tatctttcgg 2778961 gaattggatg gtgtcattgt catcggccgt gttcatgatg aagcggttaa gcatatcagc 2779021 gggaggctgg agcatgccgt atttatcaat cattcaccag atccgcaagc atacgattcg 2779081 attggcatcg attttgaatc ggcttcacgc caggcgattg atcacctttt cgacttaggc 2779141 tacaaacggt taggctacat tggcggacaa gaaaaagagc atacgctgaa ggacggccaa 2779201 agcattcgca gaacgattga agataaacgc ctgaccgctt ttttggagtc agccgccccc 2779261 cagcctgagc atgtgctgat cggagaatac agcatgcgtg agggctatcg cctgatgaag 2779321 aaagcaatcg atcaaggcca tctgccggaa gcattcttta ttgccagcga ttctatggcg 2779381 atcggcgcat taaaagcgct gcaggaagcc ggactgcaag tgccgcggga taccgcaatc 2779441 gtcagcttta acggcattga ggaagctgaa tttgccagca cgcctttaac gacggtgaag 2779501 gtatacacag aggaaatggg ccggacaggc gtaaaactgc tgcttgaccg tctcaatggc 2779561 cgaacgcttc ctcaacatgt caccctgcct acaacattaa tcgtaagaca aagctgcgga 2779621 tgtacagcaa aggaggtgac ataagcaaag attcatcacg atgataagga ggaaaagatg 2779681 aaacacactt ttgttttatt tctctctctt attctgcttg ttctgcccgg gtgttcagca 2779741 gagaaaagct cagcagatac cgcaaaaaag acgttaacca tttattctac aatgtcaacc 2779801 gacagtgaaa gagatacgtt cagaaaacta gcggcagcat tcgaaaagga acacagtgac 2779861 attcatgtca gccttcattt cccaggcaat gactatgaaa atatgatgcg tgtcagaatg 2779921 gcggccaatg atttgccaga tctattcgat acacatggct gggggaaaat caggtacgga 2779981 gaatatacag cggatctccg ggatatgaaa tggactcaag atcttgatcc caatttaaac 2780041 agcatcctca aaaataaaag cggaaaggtg tatgcctatc caatcaatca ggcaaaagac 2780101 ggtctggcgt ataatcgcaa tattttagac cgttacggca ttgctccgcc ggaaaccatg 2780161 gatgacttta tcaaagcact gagaacgatt aaagaaaaga gcaagggaag cattgttccc 2780221 ttctggtttg ccggatatga caaaagctca ttcgcccaat attacgacca attcgctaca 2780281 cctcttctca tcacagaccc tgcccataat gaaaaaaaac agctcatcaa cggcactttt 2780341 caatggagta aattcactta tttatcagaa atcctcaaac aaatgcagaa agaaaaattg 2780401 atcaatatcg acgccgtcac ggcaaaaaaa tcacagctca ttgaattaat ggcccaaaac 2780461 aaaatcgcct ttacaatgca aggcggcaca ctcggccaag acgttgccca gatcaacccg 2780521 aacgtcaagg tcggcattat cccgacacct gccatccatc ccggtgatga cccgatatgg 2780581 atcggcggtg aacgctacac ccttgcagca tggaaagatt cgcctcaatt aaaagaggca 2780641 aaagatttta tcgcatttat ggcccgcccg gccaatgcca aacaaatggc tgaagccaca 2780701 tcgcttcctt cagggctgac caatgtgaaa gctgatattt tctacgcaaa cgattatgag 2780761 tattatcaag atgtcaaagt cgagccttac ttcgaccggt tatacttgcc aaacggaatg 2780821 tgggatgtcc tgggcacggt tgggcaggag ctcgcggctg acattttggc gcctcaagac 2780881 atttcgcaga agctgggaag agaatataaa cgactccggg agcaatccga aacacaggga 2780941 gctgaaaaca atgagtgaga tcgcaaggga cgttcatgtg aaacaggtta agccaaaaaa 2781001 gcagtcctca ctttggtgga tgtacattcc tgctttgctc tccgttctgg tctttatgat 2781061 ttacccgttt gtgaaaggca cattgattac ctttacaaac tggaacggat tttcacaagt 2781121 ctaccaatgg gttggattcg cgcaatatga aaggctgttt tctgatcctg atacttggca 2781181 tatcttaaaa aacacgctgc attacgggct tggcagcacc ttttttcaaa atgtggtcgg 2781241 gcttctgtac gctctcctct taaatcaaag cattaaaacg aaagcggtaa caagaacaat 2781301 tgtgtatttg ccggtgatga tcagcccgct cattatgggc tacatttggt actttttctt 2781361 ctcctatgac ggaggcgcgc tcaacgattt gctcggggtc ttcggcatca gccctattaa 2781421 tgcgctcgcc agtccctcgc tcaatccatg gatcattgtc atgattaaca cctatcaata 2781481 tgtcgggatc gctatggttg tctacttagc cggtctgcaa agcattccga aagactacta 2781541 tgaagcggcg caaatggatg gcgcgaaaca aggccagcag ttttttacca tcacgctgcc 2781601 gctgttaatg ccctccatta ccattaatat agtcatcaac attatcggag gcttaaagct 2781661 gtttgacgtc atcattgcac tcaccgcagg cggccccgga aatgcgtcac aatccatgtc 2781721 cacgtttatg tatgatttgt atttcaaacg gcaggatgcc ggctatgccg caacgcaagg 2781781 catatttatg gcatttgtca ttttgatcat cagcttttgc gcgcttgcgt actttaaaag 2781841 aaaggagacg gaaatgtcat gagagccgcc cgtacaaaaa gcatgcggat cattacgctt 2781901 cttgcagcca ttgtggcctg tgcgcatttt attccttttt atatcctgct gaccacttca 2781961 ttgaaagcaa aaggagacta cagttcgaaa tggatatttc cagccgacat ctcctttcat 2782021 aatttttcag aggcgtggga gcgcgcttcg ctaggaaact cttttataaa caccatgatc 2782081 atcacaggtt tttctgcctt gttattaatt atattcggct cacttgccgc ctacccgctt 2782141 gcccggcggg aaacgaaact gaataaagcc gtttttgcct tgctgatttc cattatgatc 2782201 atccctccgt taacgtccat ggttcctttg taccgaatgg tcgtggacgc cggaatggtc 2782261 aatacacacg caatcgccat tttcatcaat acagcggctt acatgccgtt aaccgtattc 2782321 ttatattcag gctttatccg atcgaccatt ccaaaagagc ttgtagaagc cgcaagaatt 2782381 gacggtgcag gcatgctgaa aatctttttt acgattgtgt ttcctctgct gaagccgatc 2782441 actgcgacca tctgtatcat ttcttgtgtc tttatttgga acgactatca atttgccatt 2782501 ttctttttac aagatcaaaa ggttcagaca ttaacagtag ccatggcagg ttttttcgga 2782561 gaaaacgcaa acaaccttca tttagttgcc gcagcggcac ttatggcaat gctgccgatg 2782621 gttgttctgt ttttggcgct gcaaaaatac tttattgccg gcctgtcttc cggagcggta 2782681 aagggttaac attaaagggg gaagcaatat gaaaaagatt acatttatcg gtgcagggag 2782741 cacgattttc gccaaaaatg ttttgggaga ctgcctgtta acagaggcac tgaatggatt 2782801 tgagttcgct ctttacgaca ttgatcccaa acgcctgcag gaatcccagc tcatgctcga 2782861 aaatctaaga gaccgttata acccaagtgt ggccatcaac agctatgatg acagaaaact 2782921 cgccttgcaa aacgcaggct atgtcatcaa tgcgattcag gttggaggat acaaaccgag 2782981 cacagtcatc gatttcgaga ttcctaaacg gtatgggctg cgccagacga tcgccgatac 2783041 agtaggcatc ggcgggatat tcagatctct cagaacaatc ccggtcttat ttgatatcgc 2783101 aaaagatatg gaggaaatgt gccctgacgc atggttctta aactatacaa atccaatggc 2783161 cactcttaca ggcgccatgc tccgctatac caatatcaaa acaatcgggc tctgccacag 2783221 tgttcaagtg tgcacgaagg atttatttaa agctctcgga atggagcatg acggaattga 2783281 ggaacgcatt gcgggcatta atcatatggc ttggcttttg gaagtcaaaa aagacggcac 2783341 agatttatat ccagaaatca aaaggagagc gaaagaaaaa caaaaaacaa agcatcatga 2783401 tatggtgcgg tttgaattaa tggataagtt cggctattat gtcacggaat cgtccgaaca 2783461 taacgcagag tatcacccgt actttattaa acggaattac cctgaactga tcagcgagct 2783521 gcaaatcccg ctcgacgaat atccgagaag gtgcgtcaag cagattgaaa attgggagaa 2783581 aatgcgggat gatatcgtca ataataaaaa ccttacgcac gaacgctcaa aggaatatgg 2783641 ttcaagaatt atagaagcaa tggaaacaaa cgaaccattc accttcggag gaaacgtctt 2783701 gaatacaggg ctgatcacca accttccttc aaaagcggtt gtggaagtga catgcgtcgc 2783761 cgacagaaaa aaaattacac cgtgcttcgc cggagaactg cctgagcagc ttgcagcctt 2783821 aaaccggacg aatattaata cacagctgat gacaatcgaa gcggctgtca cacgaaaaaa 2783881 agaagcggtt taccaagctg caatgcttga tccgcataca agcgcggagc tttccatgaa 2783941 ggacatcatc tccatgtgcg acgatttatt tgcagcacac ggcgattggc ttccggaata 2784001 caaataaaaa ctaggggacc gctctcccct agttttttgg ttttgtttcg ccttcccagg 2784061 ccatcatgcc gccttcaaca ttgactgttt taaagccttg ctcatccagg tacttgcaga 2784121 cgttcatgct gcgcattcct gagcggcaga taaatacgta ctctttgtct ttatcaaggg 2784181 tttccatttt ttcaggaata tcccccatgc gaatatgaac ggcttgcggg atcatgcctt 2784241 ccgctacctc ttcatcttct ctgacatcaa ttaaatataa ttcttcgtcc gcctcaattt 2784301 tttctttcaa agcggctgtg ctgatttctt ttatttccaa agaaaacact cctattcaca 2784361 gtgatcatgt tcagtatatc aaagtcagcc gaacgattgc tattctgaga ctgatgaaaa 2784421 aaaatcccct tttggcaaag gggatttttt ctaggcttag tttgccacaa tattgacaag 2784481 cttcccaggc accgcgatga ttttccgaat cgttttgcct tcaagctgct ctttgacctt 2784541 ttcatctgct tgagcaagct gttccagctg ttctttcgtt gcatcggcag gaacctgtaa 2784601 tttcgctttt acttttccgt tcagctgaac aacgatttca acttcatcat ccacaagttt 2784661 tgtttcatca tatacaggcc aagcttcgta ggcaattgtg ccggaatggc caagcttctc 2784721 ccatagctct tccgctaagt gtggcgcgac aggagaaaga agcttcacga agccttccat 2784781 atattctttc ggcagttctg ttgctttata agcttcatta ataaagacca tcagctggga 2784841 aatacccgtg ttgaaacgaa ggccttcata atggtctgtg actttcatga ccgtttcatg 2784901 atagacgcgc tccaatgttt cacccgcgcc ttcaacgatt tttccattaa gctcaccgct 2784961 gtcttcaata aataggcgcc atacacggtc aaggaaacgg cgcgcaccgt ctaatcctga 2785021 ttcagaccag gcgattgaag catcaagagg tcccatgaac atttcgtaca atctcagcgt 2785081 atcagcaccg tgagaggcca cgatttcgtc aggattgaca acgttccctt tagatttact 2785141 cattttttcg ttgttttcgc cgagaatcat tccttggttg tacagctttt ggaacggttc 2785201 tttcgtcggc actacgccga tatcataaag gaacttatgc cagaagcggg catacagaag 2785261 gtgaagcacg gcatgttctg caccgccgat atacatatcg accggaagcc atttttccaa 2785321 tttttctggt gatgccagct gatccggatt gtgcggatca atatagcgca agaaatacca 2785381 gcagcttccc gcccattgcg gcattgtatt cgtttctctt cttccttttt tccctgtctc 2785441 agggtctgtg acttccaccc actctttaat gttcgcaagc ggtgattcgc ccgttccgct 2785501 cggtttgatt tcatccgttt ttggcaaaat cagcggcagc tcctcttccg ggacagctgt 2785561 tgacgttccg tcttcccaat gaatgaccgg aatcggctcg ccccaataac gctggcggct 2785621 gaagagccag tcacgaagac ggtacgtcac tttcttctca ccgtttttcg tttcttccag 2785681 ccaagcgatc actttttcaa tcgcttcctg tttgtgaagg ccgttcagga aatcagagtt 2785741 cacgtgctcg ccgtcgccag tataggctgc ttcctcaacg ttcccgcctt ttacgacttc 2785801 cttcaccgga aggccgaatg ttttggcgaa ttcaaaatca cgctcatcgt gtcctggaac 2785861 tgccatgaca gcacctgttc cgtatgatgc aagaacataa tccgcaatcc aaatcggcag 2785921 tttttctccg tttacaggat tgatcgcata cgctcctgta aatacgcctg tctttgtttt 2785981 cgcaagatct gtgcgttcta ggtcactctt tgattgaatt tctttgatat aagcttcaac 2786041 agcttctttt tgctctgccg ttgtgatgtt ttccaccaat gcgtgttccg gggcaaggac 2786101 agtgtatgta gcgccaaaca gcgtatctgg tcttgttgta aacactgtaa aggaatcatc 2786161 atgtccatct atagcaaaat gaacgtgagc gccttccgaa cggccgatcc agttgcgctg 2786221 catatcttta atgctttccg gccaatcaag ctcttccaag tcctcaagga gcctgtccgc 2786281 ataagcggtg attttcagca tccactgctt cattgggcgt ctctctaccg gatggccgcc 2786341 gcgttcgctc ttgccgtcaa tgacttcttc gttggcaaga acagtaccga gcgcagggca 2786401 ccagtttaca ggcacttcgt caacgtaagc aaggcctttt tcgtatagct ttaagaaaat 2786461 ccattgcgtc catttatagt attcagggtc agtcgtattg atttcgcgat cccagtcata 2786521 tgagaagcca agcgcttgaa tttggcggcg gaagttatca atattctgct tcgtaaacac 2786581 agcggggtcg ttccctgtgt caagcgcgta ctgttcagct ggcaggccga atgcgtccca 2786641 gcccattgga tgaaggacat catagccctg catgcgcttc atgcgggaca gaatatccgt 2786701 agctgtgtat ccttcaggat ggccgacgtg caacccagct ccagacggat aaggaaacat 2786761 gtccagcgcg taaaattttt gtttttcatt attatcaaga gtggcaaatg ttttgttttc 2786821 aagccaatat gtctgccatt tcttttctat ctctttgtgc tgaaaactca aagtaaaaac 2786881 ctccttctga ttgaatacgg cgtgtatggt tcaagtattg acgggaagga gaggattata 2786941 ttcagaatat tcccaaacta aaaaaaactc cctcatccca aaaagggacg agagactttc 2787001 gttttcccgc ggtaccaccc tcgttagcgc ggcatacgcc gcactcactt gatactttta 2787061 acgcagttat gcgtcagcgg cttttcaccg ctgcaactct gaggtgagtt cggaaacaaa 2787121 cttgattgac tttcaccagc cgtcaactct ctgcaacaat atctgtttct tactgctcct 2787181 cttcattgtt cttatcgcaa ccgtaatcta actgtatttt atagaattct gttcataagt 2787241 gcaagcaggt ttgtatacaa tgggaatgta ccctgaacgg gcggagattg aggacaatta 2787301 ttcgggtgga gttttggttt gacgtttgga ctcggccggt tcgccgccgc tgttcagttc 2787361 tctcacaaag tcaaaacttc tgagaacagc ttcaccgccg tagcctgaga taatggataa 2787421 gatgacaagt tgaattcctg aatcggggtc agcggataat acaagtaaaa tggaagccgt 2787481 catgccgata aaccaatctt ccaaaaatcc aaggtagata aaccgcttcg tcattctggg 2787541 cttctccagc ctgcctctct ttttcacatg accgagaatc cccatgattc ctccaattac 2787601 acaagcaatg agtacctgat gcagcatctt catcatcacc ttcctaaagc ccttatttcg 2787661 taaagcgact tcaggccatc cagccccctt aaacgattcc gatgattttc gatatctaca 2787721 taccggcaaa tctgtaaaaa gcttgtttct tccattatat gtgaacacat gatcggtaag 2787781 cttgatgcat tggattcatt tttcacccag tgacattgac ctagtcacct atttagcatg 2787841 tagaaaacct ttccgttcat atgttcaaat tctgttctta tttttagtgt atacgaggac 2787901 aagccctaat gacaaacaac aaactgcact tgcttgaatc agaacatgtg ttgtgctacg 2787961 gttactgtag aattcatttt taaaaagggg aatatcaggc tttcgcatag caagctgacg 2788021 gcctaagggg gatttatatg gctagttttc aatcatttgg gataccagga cagctggaag 2788081 tcatcaaaaa agcacttgat cacgtgcgag tcggtgtggt aattacagat cccgcacttg 2788141 aagataatcc tattgtctac gtaaatcaag gctttgttca aatgaccggc tacgagaccg 2788201 aggaaatttt aggaaagaac tgtcgcttct tacaggggaa acacacagat cctgcagaag 2788261 tggacaacat cagaaccgct ttacaaaata aagaaccggt caccgttcag atccaaaact 2788321 acaaaaaaga cggaacgatg ttctggaatg aattaaatat tgatccaatg gaaatagagg 2788381 ataaaacgta ttttgtcgga attcagaatg atatcaccaa gcaaaaagaa tatgaaaagc 2788441 ttctcgagga ttccctcacg gaaattactg cactttcaac tcctattgtc ccgattcgca 2788501 atggcatttc ggctcttccg ctagtcggaa acctgacaga ggagcgattt aattccatcg 2788561 tttgcacatt gacgaatatc ttatcaacat ccaaagatga ttatttgatc attgatttat 2788621 ccggattggc ccaagtgaac gaacaaacgg ccgaccaaat tttcaagctg agccatttgc 2788681 tgaaattgac cggaactgag ttaatcatta ctggcattaa gcctgaattg gctatgaaaa 2788741 tgaataaact ggatgccaat ttttcgtcgc tgaaaacata ttcaaatgta aaggatgccg 2788801 ttaaagtgct tccgattatg taaaaagatc ccgctcaccc agctggatct ttcagattgt 2788861 tgacaaaatc ctaaaatggt tttcatttta ggattttgtc atcttttcag cgtgattgaa 2788921 aacccttgaa gtctaggaag gacgagcata ggagcggagc gaatgttcta attcgtgagc 2788981 accgaagcgc aggcctgaca acgaatgcga gggtttgtcg acacgctgaa agatcccgct 2789041 cattcggcgg gatcttttat tatgaagaga ttgatgcctg cttatttgtt tctttagctg 2789101 attttatccg tttgtcatat agaagcgttg tggcaatact gatcagcagc aataccaaca 2789161 gagataaaac aagagcccta atgccgtaat gatcgacaag cactcctccg aacaggggac 2789221 caatcattct gccgcctgtc gccgcactgt tgacaaagcc ttgataaaag ccttctttcc 2789281 ctttaggggc aagctgattg gcaatagtcg gcacagcagg ccaaacaagc atttctccga 2789341 tagtcaggat caccatcgca gcgagaaaca tcggaaattg ctttgcagtc agcagcatgc 2789401 tgaaagacac aataaaaatg ataaagccga tgaccatttg cgcttttagc gactcggccc 2789461 attttttcac cacaaaactg acgagcggct ggccgagcac aatgagaatt ccgttaaccg 2789521 tccacagcac gctgtataag gaaagagata ttccaatgct ttgtgtgtac gaagcaattg 2789581 tggttgacca ctgagaataa gccagccatc cgagtacata gcctccgctt aaaatgatca 2789641 gtgcggcaaa ttttgctttg ctgttcacag catcataatc aagcacggat gtttgggatg 2789701 catcgcccgt ttgaatattt cgaaatccga aatatacaat aaagaaaaag atcagataca 2789761 atacggcatt tgccaaaaat acatatgaaa acgagaaaga tgccacgaca ccgccaagcg 2789821 ctgaaccaac ggccacgccc gcgttttgcg cgacatatat cgcattaaat gccttccttc 2789881 ccccttcagg ccataccgat cccgccattg cgtagcttgc cggaaaaaca acaccggagc 2789941 caaagcccac aatcgtcagc agcacaatat aggctggcca atcatgaaaa aagacaagac 2790001 ccatcaggct tgctaacgta atggctatcc caagcataat cgatttaaaa ccgccgattt 2790061 tatcaaacaa aaaacctccg cataaattgc cagccacact ggcgccggaa ttcagcatca 2790121 ggacaagtcc ggctactgtt aacgactttc ctaaatgatt atggatataa atcgtattca 2790181 gcggccataa aaaagaagca cccgtcacat tgataaacat tccaatgact aaaattttaa 2790241 gagcacgcgg catactcatc cccctttctt acctaaaaaa gctcatgaaa aaaacgaaac 2790301 ctaaaacggc tccgtacgaa tccagttatc atagcacatt cattctatct gtctctctca 2790361 catttttcaa ctgatgagcg tgaaaaaatc taacaaatat tgtttgaaaa atgtaaaata 2790421 aatagaaaaa ggggtcatat tatggaaatg gtattagcat tcttaggttt tctggcatgt 2790481 ctcattgcac tgggctatgg attatatcac cttgtcagat atgtactgaa aaaggaaaaa 2790541 cgtttctcaa agagactttt ttggccgctt ttcattggag gccttgtgct gctctttacc 2790601 ggggcagcat tggcagaacc tgacactgcc gcagcaaatg ccgagaaaaa atattcagcg 2790661 ctaaacgccg aatataaaaa cctcacaaaa gagcacgaag aacttgagaa agaatataaa 2790721 tctgtcagct ctgaagcaaa gaaattaaaa gacaacaaag aagatcaaga caagcttgag 2790781 aagcttaaaa acgaaaatag cgatctaaaa aagactcaga aatcattaaa agctgagatt 2790841 aaagagcttc aagaaaatca aaagcagctc aaagaagatg caaaaacggc aaaggctgaa 2790901 aatgaaacac ttcgacaaga taaaacaaag cttgaaaatc aattaaaaga gacggaaagc 2790961 caaaccgcca gctctcatga agacactgga agttcttcaa acaatacgag taaaagtgat 2791021 gaaaccaaaa cagctgacaa agcagaaggc tgtaatatca aaggaagcag aaacggcatc 2791081 taccacacgc caggcagtac atactacgac cggacaaccg atccggctga aatgttttgc 2791141 tcagttgaag aagctgaagc cgccggttat cgggcgccaa aacgataaac aaaaagctcc 2791201 agaatgtctg gagctttttc tgtttcacaa cgacgattta atgaccttct tataataaag 2791261 aactgacaga aaaccaaaaa tggagtagag cgcagtatat aacaccatca ccataatcat 2791321 aggcgcccat acctctgatc cgaataagaa ccagccggat tggacggcaa agtaactgtg 2791381 gaagaggccg acaacgagcg gaatgccgaa gttgtacatt tgtttgatgc gtatcccctt 2791441 tatcaggtcg ccctgcgtaa agccgagttt tcttaaaatt gtatagctcg gtttttcatc 2791501 ttcactttca cccatttgtt taaaataaag gatacaacct gatgtaatca ggaacgttaa 2791561 ccctaagaag ccgacgatga acatcaccat accaaacagt gatttttgcg cagcgcttgt 2791621 atctagtctt gataaatgct cgtttttctt gttcacctgt tgaaaaagct catttgcttt 2791681 ttccatttga tcgtcatgtt tcacattgac gccgataaat gtagattgcg ccagctgaat 2791741 gcgggggtct ttatccttgt ccagctgttt aaacaggctg tcatccacaa tgacagcggg 2791801 catgcccccg cttgtaaacg tgtaggacac aagaaactct tctcttaatc ctttatattt 2791861 taatggctgc gtctcgtgct tgctttttac tttaataaca ccagagtcct tgaaaaccat 2791921 tattttttgc agcaagtcgg tgtatcctga gaaaacggct tctccagccg ccacatcgac 2791981 tccttttaca tctttgtcgc taacaacagc aagctgcata ttgccgggat cgccctgcat 2792041 ctctttcgga gttccatcca taatatttgc aatgtcaaca tttgcttgca ggacaggtgt 2792101 tgcctttttt acaaacgaga tgttgctttc cctcaatttg ttttcaaata acttggcatc 2792161 tttctcattc atgaatgaaa aatcagccgc tacattttgt tcagcggtct tttccgacga 2792221 gtaatacgag atgtaagcaa gagataacag cccgatggcg agcgctgaaa cggttgtaat 2792281 aatcgtcagc agcagcgcat tcgatttcat tctgaacatg atcgaagaca gtgacagaac 2792341 ctcagaaata tttaagtagc cgcccttgct ttttcgaatg atattcgaga taaacgtaac 2792401 tgatccttta taaaacaaaa acgtcccgat aatgacgctc cccagaatga agctcatcgc 2792461 aacaaacagt tcattaatgg tcttaaattt tccgccaaac agctcagaag acacatagta 2792521 tcctgtcaaa atcaacacga tgcctaaagc gccgatcagc atttggaaaa atgatatttt 2792581 cttcactttg tcttcagtgg aggacgttac tttaaacaaa gataaaatac tctgtttttt 2792641 gataaacgta taattcatga tcatgatcaa aaggtaaatg ccgcagaaca caatgaccgt 2792701 ttggaccaag gcctgctcag aaaaatgcag tttcgcatcc gctttgacat cgacaatttt 2792761 gaacagaatc atcaagacaa gcttcgatat cgaaaacccg gccgctaccc cgatcgctaa 2792821 tgaaccgaaa tacagcatga cattttctgc acttaagatg cgaaaaattt tatgcttcgt 2792881 cattccaatt aattgaaaca gcccgatttc tttactccgt ctcttaataa aaatcgtatt 2792941 ggcatataaa atgaagatcg ccactacagc cacaagcaaa atcgaagcgg ttttaatagc 2793001 cgcggctccc ttgattgaag ccttcacttc gttaattgct ggatcatact gcagcgtgac 2793061 aaaggcgaaa taaagcgcca cgctaaagat gagcgcaaac acatacaaat agtaattccg 2793121 gagattcttt ttcaaatttc gcaggatgag ctgattaatg ttcatgctgc accccgccta 2793181 acacgccttg cgttttcata atatcctgga aaaacgtttg cctgtcctgg ccccctttat 2793241 tcagctgtgt atacatttgc ccgtccttaa taaaaatgac tctgccgcag tagctggcag 2793301 cgacgggatc atgggtaacc ataataatcg tcgcgttgcg tttttgattg agctggctca 2793361 gcttatttaa tagatcggag gccgatttcg aatcgagcgc gccggtcggt tcatcagcga 2793421 aaataatgct cgggtcatga ataaacgctc ttccagcgga tgttctctgc ttctggccgc 2793481 cggaaatttc attcgggtat ttatcccgca attcatatat tcccagttcc ttggcaactt 2793541 cctcaaactt gcgattggct tccttttttg atagtttcgt gatcgataaa ggcagaagga 2793601 tattctcttt cactgtcaat gtgtctaaca aattgtaatc ctgaaagata aagcctaaat 2793661 gctgttttct aaattcagcc agctgctttt ccttcatagc cgtcatgtca tttccattaa 2793721 tatgaatggt tccgtgactg acctgatcga ttgaggacag aacgttgagc aaagtggttt 2793781 ttcccgaccc ggaagcaccc ataatactga cgaattcgcc cttttcaatg tgaatatcga 2793841 tgcccttcag cacttcctgt ttattcagct tgtttccata actttttcga attttattcg 2793901 cttctaaaat caccatttac gcagtctcct ttatattgga taatctcatt ataaaaagga 2793961 atgccgggct tttccttcga tacggcgaac aaaaaagaaa agcatgtgac attttcgtca 2794021 cacgcttatg acatgttcaa attgattccg tattggaaag gttaatgtaa aaactgttcc 2794081 cgcaccaaac tccgactcaa catcaatatg gatcaataac ggcgccgctg ctttttttgc 2794141 caagtacagc cccatgccag ttgacgcttg atcatggtga tccgttgtgg atgtaaaccc 2794201 tttatcaaaa atacgcggta catcttttgg atcaatgccc ctgccacaat ctttcacttg 2794261 gagctgcgtc tgttcccctt tttgaaagct tttgatctcg atttcagagg cttcgctgta 2794321 tttcaccgcg tttgtcagca gctgcctgat gataaacgcc agccattttg catcgctcag 2794381 cacttctttg gcctcgagct gtatgtcaaa accgatccct ttttggatac accacgattg 2794441 taaatctttg atttctttaa agatcaaagg ctgaagctga atgaattcta ctgacaggtc 2794501 gttttcaata aatgaaatgc gtttttgatg aagctgctga tcaagaagca ggtgaatacg 2794561 cagccattca tatgacagct gggatttcag tgctttttct tccattctat caatgattaa 2794621 atgcatcgct gttaatggag ttttgacctc atggatccat gccatcagct catctttttc 2794681 attttccaat gctaagcgat gccgtgctgc ggtctgcttc aagtgttctg tttgcccggc 2794741 aatgcttctt tcaaccattg cttcaaacgg cgtttccggt tcatttatgg ctgtcacatc 2794801 gagattgttc tcccatgttt tcaagctttt ataaaacgct gtttctttcc gatagcggaa 2794861 ccaaaggaat atgataaaaa acaagatgca caaatacacc atataaagta cattcccaaa 2794921 tgatatggaa ggatcgacaa aagcaatgaa cagcatcaaa gcctgctgaa acaaaaacgc 2794981 ggcaatccag ctccgccttt cgataaggaa tgctttaatc atagaacttg tcctcttcct 2795041 tcgcgatgta gccctggccc acctttgtct cgatatatgc accaagctgc agggcgtcca 2795101 gtttttttcg caggcgattg acattgacgg tcagcgtatt atcactaaca aaacgctcat 2795161 cgttccacaa gcttctgatc agctcttccc ggctgacgat cttgtttttt tgctctatta 2795221 attgttttag aatgaacatt tcatttttgg tcagttcaac agatcctttg tcattgctga 2795281 cgaggttctg ctccgcgtct acagcagcgc cgcaccacgt tttaatcgta ctcggctccg 2795341 tattataatg gtgcacacgc cggaacatcg cttggatttt cgcgatcagc acatcaaaat 2795401 gaaatggctt ttgaataaag tcatctgccc cgagctgcat ggacatcacc atatcagcag 2795461 gatgatcccg ggaggataaa aagagaatcg gaacatttga ccgggagcgg atcagacggc 2795521 accaatgaaa gccgtcaaat ttaggcagct gcacatcaat aatgacacaa tcaggattaa 2795581 ccgccgcaaa ttcctgcagc acctgactga aatcctgaat gccgtataca tcataggacc 2795641 atcccgttaa acgatccttg atttcatgaa acagcgattc atcatcttca atcagcaaaa 2795701 gtttaaacaa tcgactcacc gcactttttc cttttttatc aagtgtatag caaaacgcca 2795761 gcatgcgcta tagaaaaagc cggctgtctc agccggctcg ttcgcattat aattctcttc 2795821 tcaacgctgt cagcacgttg gttttggtag cttttctcgc cgggttcatt ccggaaatga 2795881 ctgcgacccc tccgcaaatc acaacggcaa tgatcacaag gctcgccggg atgtaggaga 2795941 atgtgtaatt caaatcgccc gcatcgccac cgcttgtggc cgcaagaatc atcggaacgg 2796001 ccaggttgac aaggtagctc acgccgtaag aaatgataat cccaatcaca cagcctaaaa 2796061 ttccgatata cgcgctttcc atcaagaaca ttcggcgaat gattgacggg ctcgccccaa 2796121 tcgctttcat aatgccgatc tcttgcgttc tctctgtcac cgccatcgtc atcgtgttaa 2796181 aaatgccgat cgctgaaatg ataactgcga tacatccgac aaagatcagt ccgattttga 2796241 agaccatgaa gaaggtattg gctccctcaa gttcagtagt cactgatgtg acatagtacc 2796301 cgtcatctgt tagatcattt gtcagctgtt ccacattctc aaacttatca gcaaaaacac 2796361 caatgttcgt ttcaacattt ccgcctttga aatctaagaa ttccgaaaaa tcttttttga 2796421 attgatcact gataaaaata tttgagtcct ccatccagtc ttgagatggt ttttttgtaa 2796481 taccgacaat tttaaagtca tatgtttttg tttttgtaac atcccctgtt ttagaatctg 2796541 tcttcgatac acttagttca attgttttat ttagaatatc tttcgtatag ccctttggtt 2796601 cttttatatc ttctggattt ccttttgctt cctcgatttt tttgttatat tcttccgatt 2796661 cttttttcgt taataatctc tttgcgaagt cgtatcctac tacgatttca ttttccgact 2796721 ttgcgactct tcccttttcc aattccatat tggcctttaa ttcatcattc atattagtaa 2796781 aaatgagatt tgagctttca tttgtacgat tgcctaaagt agctttgttt ggttcataca 2796841 cttgcgttct ttctacaact gaccttacgt gatcatactt ctctaaatca gcttttttaa 2796901 tcggcttgtc tccttccttg cccattacgc tgactttcgt tacaatctgc tggctcattg 2796961 tcatatctgt aatcgtcttt tgaatcccaa atccaacgga cgacaacaca accaaaaacg 2797021 cacacgccat tgttgtcgcc agaatcgtca taaagacgcg aagcctgttt ttcttcatat 2797081 ttcttctgat aaaatgaacc tgatccttaa acctcaacgg taattcctcc ttttagcaca 2797141 ccatcatgaa gctgaaattt tgaatgtccg atagaagcga cttcatcatc gtgagtaatg 2797201 atcacaaatg taatgccacg ctcacgattc agctgctgga tcaattccag cacttcatgt 2797261 tccgtttctg aatcaaggct tcccgtcggc tcatccgcta agataatcga aggatttaaa 2797321 atcaatgctc gagcaatact gacacgctgc tgctggccgc ctgacagttc attcggataa 2797381 tgagcggcgt ggttttccag accgacgcgt ttcagcatgt cctgcacctt ttgcttccgc 2797441 tcagatggct tgattccttt taacgccagc ggcatttcca cattctcata cgtcgttaaa 2797501 cccgggatga gctgaaagct ctgaaaaata aacccgaaat ggtcaagccg aaattgcgcc 2797561 cattcctttt cattaaaccc cgtaacatca gtgccattaa tgacaatccg cccttttgtc 2797621 ggcgatatgt agccggaaat taaattcaaa agcgttgatt tccctgagcc gcttcgtccg 2797681 acaatgcagg cgatttcccc tttcgccacg ctcaatgaaa catccttcaa tactggaact 2797741 tcattctcac ggcccttttt tccgatcgtg aaagaatggt cgatatgctg aacatcaatc 2797801 atatgttctc tctcccttac aaaagtttca tttttttata aatcgcaaaa taactaatca 2797861 agaaaccgat taccgcacct gtacccatgc caatgagata accggcaaag ctctcgcttg 2797921 cagtaaatcc aaaatagccg aagcccatga ttcctatgat aataacgatg atctgcaccg 2797981 ggcggttaag cggcttccat aagaagaaat atccgtttct ttcattagac attttaacaa 2798041 agctaatata gccgatgatg taaaaaatga tagtcatgat agccggaatg actaaataat 2798101 atggtgaatt ctcagcccat ttcgagtcta cataaattat cggaatgaaa tactgcaccc 2798161 atttaggtac tggaccatgg ataaaatcta ttgatccgcc aaaaaggatc tcgaggttga 2798221 tcacaggcag gctgatgagt aaaaacggcg aaatggccac ggtaaatgag actagaagct 2798281 gtgcgaaact attgcctgtc aaagctcctc cggccataac caaagaataa gccagcatgc 2798341 taacaataat cattcccaag ctgtaattgt gaaaataaac ggcctgatct ggcttcaaaa 2798401 gcatgatcag caaaacagac aaaacataac ctatgagctg cggcaccaca atcaccattc 2798461 cgccggtaag gaacttcgca tgaaatatct gccctcgtgt atatggaagg cttaatgtaa 2798521 aatcaaagaa gctcttgcta cgttcaatcc caagctggct gaccgccaaa acgactcccc 2798581 aaatccaaaa caatgagata aatgagctat ttaaataatc aacgctgaat acgcaggggc 2798641 cgacccaatt ttcttttcca gtgacacagc cttgatagat gagatacata tttaaaattg 2798701 ataatggatt acctaatata aaaaccaaaa tggtgataac taaggcgact ttattctgcc 2798761 gccactcttt gtaaagcagt ccggaatccg gcaactcact tccctccaaa cctaaggcat 2798821 ttcttacact tttgttttct tataaataga gaagtagctc acaaagaatc cagccactgc 2798881 tccaatgatc atacccaaaa tataaccaat aatggaatgt ccggtatagt atccaaataa 2798941 accaaatcca aggatgccga aagccataac cagaatttgc accgggcgat ctaatctgtt 2799001 ccataagaaa aagtgtccgt tccgttcact tggaagcttc ttgaagctta taaagccaat 2799061 caagtaaaat agcatgctca ttacggctgg aatcaataaa agatatttac tgttaatcag 2799121 ccattcattt acaacgtaac taatcggtac taggttcgat aaattgcttg ccagagagaa 2799181 ataactctca ggggaaggga atatttccca tatattcgca ccaaaaacaa cttctaggtt 2799241 tccaaccggc aatgcaataa ttaaatacgg caatatagct gctgaaaacg ccgttaacag 2799301 ttgggcaaaa gcatttccag ttaacgctcc ggcggccatc accagtgaaa aagccataaa 2799361 acttatcacg attactccaa tgctgctgtg ctcaaaaaag tagacgtgtt cagggttata 2799421 gacaagaatc agcagccatg caagtaaaaa gccaatcaat tgtgacagca caatcacaaa 2799481 accgcctaac caaaattttg tctgaaaaat ttggcttctg ttatacggga ggcttaatat 2799541 aaaatccatc gtgcctttcg aacgctccat tccgaggaag cagaccgcca aaatgacacc 2799601 cggcacccag ttgatatcta tcagattgct tatggaataa ttcacaataa aatcacaata 2799661 ttgcgggtct tggcgatcaa gacacccttg ataagacaaa tacgtattaa cgatagaaag 2799721 cggatttgcc aatactaaaa acgcgatact taacaaaatc accacttgat tctgcttcca 2799781 ctctcgatag aggagacctc ggtctaccat ctccgcttcc ctccaaactt cgcaatgaac 2799841 acttcttcca ggttgacagg aagctcattc cacacttttg gcttcagctc tctcaaaaag 2799901 ctctttttct cctcatcgct tttcggaatc agcactgtgt aaaacacgcc ggcctgatcg 2799961 agcatcggaa tgttttgctc tctgatggcc aaattgacat ctgtatcgaa ggccatttga 2800021 attttaatgt attcttcttt taactcatca agatccatga cgttggtcag gctgttatct 2800081 tcaagaaaac caattcggtt gcacatccgc tctatgtctt caagccggtg ggacgtaatc 2800141 aggatgctcg tatcacgctc tgccacttca tcgaccatca gctgcagcac atcatgcctt 2800201 gtcaccgcat caataccatc cgtcggctca tcaaggagga tcagcgccgg tctcgccgca 2800261 aacgacagaa cgagcgatag ctgctttttt aagcctgtcg acagctcacg gtattttttc 2800321 gtttccggaa tttcgtatct gttcatcagc tcattcgcgt acgtgacatc aaatttcgga 2800381 tatattcttc tcaaaatatc gactaactgc ttgtatgtat acttatcgta aaacggattt 2800441 tgaacaggca tgtagatgat attttgtttg actttcgggt gctttttgat ttctacgccg 2800501 tcaaataaaa tcgttccgct gtcagcgaaa atgatttgct ggattaagcg aagcatcgtc 2800561 gttttgcccg atccattgcg tccaagcaat ccaaagattt ctcctttttc gattgttaat 2800621 gaaacatctt ttaatacttg attgccgtca atcgcttttg acagctgccg cagttcaatc 2800681 attttttttg cctcccttca catcagcgct gatttccttt atccattcgt gcagtttttc 2800741 cagctcaacc cctgcatagt gtgcatcgat gatgagctgt ttgagttgct ctttaatcat 2800801 cgtcatcttc ccttcaacca gtgtcgtttt tgcattctcc gatatatagg tccctctgcc 2800861 ccgcagcgtt tcaataatcc cctctcgctc aagttcttta tacgctttgc tgacagtgtt 2800921 cggattcgca ataatgatcg ttgccaattc tctgacagaa ggaagcttat caccaggctt 2800981 catgatccct ttcaaacaaa gctctttcat ttgctgaata atttgttcgt aaatgggtgt 2801041 tgagcttctt ggatcgattt gaatcattta cttccctact ttctatacga tctgaacctt 2801101 ttatagataa aaatgatcaa ttatactttt ttgccattca aaaccgatca tcacaagaac 2801161 aagaaaaaaa gaacaagcga tcacagatgc cgcaatcagc attggcacgt tacgtttgtt 2801221 tcgtttttta tgtttcataa ctgcctccct taatgtcaat atataaatga ttttatatta 2801281 gtgtctatag tgtattactt caattagtac acttaataca ataaatactt tgactcacaa 2801341 agtcaatcct ttttttacaa aaaaacggac ccttttaaaa gggtccgttt tcctacacat 2801401 caagagggtg ctgcaggatc atattatttt gcaaagattg aagctgaagt ctcattctgt 2801461 acagctgttc tctctgctga tcatttgacg acagccatag tttattcaag gcatttaccg 2801521 catcttctag ctgcatttgt gcatcactat attcttgatc gttataatgc tcttgtttag 2801581 aagcgatttt cagctgttct tcagcataat cataggcctg catacattgc tggagatgtt 2801641 catctactga ttgtcttgtt gccacagtaa cccctcctct tggtaatgga aatcatccat 2801701 cattcatatt gtagcctcat ctgactttat tcaataaagt aatttatggt cgatattcat 2801761 ttgttctctt gtgaaatgcg tgctacaatt ttaggatgca atcgtacgca aggaggcaca 2801821 tgaattgtga tgcagaacaa tccttttcct tattcaaata cggaaaaacg ctatcataca 2801881 ttgaattatc atctcagaga acatttcggc cataaggtgt ttaaagtagc gcttgacggc 2801941 ggttttgact gtccaaatcg ggatggcacc gtagcccacg gaggctgtac gttttgcagc 2802001 gcagcaggct ccggagattt tgctggaaac cggaccgatg atttaattac gcaattccat 2802061 gacatcaaaa accgcatgca cgaaaaatgg aaggacggca agtacatcgc ttattttcag 2802121 gctttcacaa acactcacgc cccggttgag gtgcttcgtg agaaattcga atccgtcctc 2802181 gccttagatg atgtggtcgg catttcgatc gccacacgcc cggactgtct gcctgatgat 2802241 gtcgttgatt acttggcaga gctgaatgaa cgtacgtatt tgtgggtgga gcttgggctt 2802301 caaacagttc atgaacggac tgcacttttg atcaaccgcg cacatgattt taactgctat 2802361 gtggaaggcg tcaataaatt aagaaaacac ggcatacgtg tctgctcgca tattatcaac 2802421 gggctgcctt tggaagaccg ggacatgatg atggaaacgg caaaggccgt cgcagatttg 2802481 gatgtccagg gcattaaaat ccatctgctt cacctactga aaggcacgcc gatggtcaaa 2802541 caatatgaaa agggcaagct ggaatttctt tctcaagatg attatgtgca gctcgtctgc 2802601 gatcagcttg agatcattcc gcctgaaatg atcgtccacc gcattacagg tgacggaccg 2802661 attgagttga tgatcgggcc aatgtggagc gtcaacaaat gggaagtgct tggcgccatt 2802721 aataaagagc tagaaaatcg aggcagctat caaggaaagt tctttcaacg gcttgaggag 2802781 gaatcagcgc tatgattttg aagaaaattc ttccttacag caaagaactg ctgaaaatgg 2802841 ccgcgggaga gggagatatt gtcgtagatg cgacaatggg caacggacat gatacacagt 2802901 ttttagcgga gcttgtcggt gaaaacggcc atgtatacgc attcgacatc caagaatcag 2802961 ccgtggccaa tacaaaggaa cggctcggtg acatgtatca agcgcgaaca acgttatttc 2803021 acaaaagcca tgataaaatc gctgaatccc tcccgcctga aacacatggc aaagtggcgg 2803081 ccgcggtatt taacctcggc tatttgccgg gcggggacaa atcaattacg acaaacggca 2803141 gttctacgat caaagccatt gaacagcttc tcagcatcat gaaagacgaa ggtctgattg 2803201 ttctcgtcgt ctatcatggc cacccggaag gcaaagctga aaaaaacgac gtgctcgagt 2803261 tttgccggga cttggaccag caaacagccc gtgtattaac atacgggttt atcaatcagc 2803321 aaaatgaccc gccatttatt gtcgccatcg aaaaaaaagc tcagatcagc aaatgatttg 2803381 agcttttttc tttgaatttt tcatccagga cattttttga aatttccggt aggctctgcc 2803441 gttgatataa aagaaaaggg aggtttttcc gctggctttg atcagcttct ttgcgagccg 2803501 gcccatttcc ttttggcctg ccactttatc atctgacaaa taaacgccaa gcaagccgcg 2803561 attgattaaa cgatggaagt tttcatgcgg aatgccttgt aaatgctcgt cggctttatg 2803621 gataaagtgt tcaagccggt ccatcatctc ttcatgagac tgataatacg agcagaaatt 2803681 caagtctcct tccagcaagt cctcctcttg atcaatcaaa taatcaagaa gaatatgaag 2803741 accctgtatg taaggaaaat aactgtctcg gattttttta gcggtgcttt ctgtgaaatc 2803801 aggctggaac gaatacgcaa ccagacagaa aatgcctaac gttgagcctg cacaggctga 2803861 aaattcatac cattccatct caggcagctc tgattcatat tgagtaaacc acttttcaag 2803921 ccgcggaaca cgctcatgct caataacgtg cttatgcacc tgcaaatcgc aataatagcc 2803981 gcacagttca agcagataag gtttaatcat gtcatagtgc tcaatggagc cgagaacacg 2804041 ctggcacgtt ttaaccagtt catgcaaata tccgctgtca tcctgttctt ccctgaattg 2804101 ataatagttt tgcagttccg ccccaactgt cagtgcgtcc tgcattgagg catggagcat 2804161 ccgaaaatcc tgcgggtcca gcgaggtgct gcggtcacac agattgtcca aataatcact 2804221 aatcgtttga tacgcgatga taaactcgac acatttctgc ttttggctgc ctgacaataa 2804281 ggccagtatg ccgccgcctt cacagtgaaa cgttttgtcc cgaatacttg cggttgcctg 2804341 tgctttcaat tcactgttat gaatcgattc tgatttttgc ttccatatgt ccagctcttg 2804401 atgaacgagc ggaaaaatat ctcgatatac ctttgccatc aatccaaaag gatgttccgg 2804461 tactgtcaac acatgcaccc cctactagtt caaatatatt gatcagtaaa cgctcttgct 2804521 gctttaaaaa catcttctct ctcgggttca ttgaagatct catggtaaag cccttcccac 2804581 tctctgtatg ctttattatg agaagcaaca ccattaaacc acttgatgac catcgttttg 2804641 tcaacaagct tgtcatcacc ggcttgcatc acaagaagcg gaactttcaa aaatgcctct 2804701 gtcggcacca ttgccgattc aattgtcttt aaaagctctc tgtaccatct gacagaaact 2804761 ttcctgacgt ataacgaatc attttggtca gcttcgatga cgtcctcatt gcgcgtcgcc 2804821 atatcaattg ataatcccga atcaacctta agtgacggag cgatgacatt caggcctttt 2804881 gatgcaagat caagcgcttt attcacttta atttgcagtc cgagacacgg tgatgataaa 2804941 ataattcccg taatccgggg atttctttgc tgtttaaccc attcaatcgc gaccagaccg 2805001 cccatgctgt gacctagaag aaaaaccgga agatcaaagg ttcgcgcttt atctatccaa 2805061 gcatctactt catcaatgta ttcttgaaac gagcgaatat gccctctcgc tcttgtcgtt 2805121 gttccctgtc caggcaaatc gcccatgaca acgtgataac ccgaagaccg ccacatttca 2805181 atcagccatt tatatcgtcc gtgatattca cttgccccgt gaatgattac aatcacggca 2805241 acaggtctgt ctgctttcca ggtccacatg atcttcacct catacgaaat ttaaatagag 2805301 aaagaaggat gaatcttatg atctaccctt ataaggaaca caagccagat atccacccaa 2805361 cagcctttat agctgataat gcaacaatta ccggtgatgt cgtgatcgga gaacagtcca 2805421 gcatttggtt ttctgttgtc ataaggggag atgttgcgcc gaccagaatc ggaaacagag 2805481 tcaatatcca agatttaagc tgcctccatc aaagcccgaa caagacgcta ctcattgaag 2805541 atgacgccac gataggccat caggttacac ttcatagcgc tgttatccgc aagaacgcct 2805601 taatcgggat gggctcaatc attttagacg gagccgaaat tggcgaaggc gcttttattg 2805661 gtgccggcag tcttgtcccg cccggaaaaa tcattccgcc tggccatctc gcctttggcc 2805721 gccctgcaaa agtcatccgc cctttgacgg aagaagaccg aaaagatatg caaagaatac 2805781 ggtcagaata tgtagaaaag ggccaatatt ataaatttct tcaacaaaca taagacctgc 2805841 ttcgtcttac tttaccattt ttcaaattat atttgaaagc aataaccatc gttaacccgg 2805901 acgtcataca gttcgggttt cgatttttcc ataaaacgtt cacatatagc atgaaacgta 2805961 tgacttttat cttatcacaa aactataaac agcctctgca aaaacacata cctattcttt 2806021 cctgttctct attttctatg agcacacaca aaaagagccc actgggagct ctttttgtca 2806081 gctgatattt cgttcgctgg cagcagccgc atttttttta tgaaaccctt ttccatagta 2806141 cacagccagc aagatgagaa accatatcgg cccgataatc acggctactc ttgtatcagg 2806201 gctgtaagcc ataagaatga cgacgaatgc tagaaatgcc aatgacacat aagacgtaaa 2806261 cggaaataaa ggcattttgt actttaattg tttcttttct tccggcttca aacttttcct 2806321 gtattttatt tgagaaagca aaatgattgc ccacgtccaa atcgctccga acgtcgcaat 2806381 acttgtaacc caagtaaata ccttcgcagg gacaacatag tttaacagca ctccgactaa 2806441 taaagcgccc gctgaagcca gaacagcttt acccgggatg ccgcctttcg tcagctgacc 2806501 atatgcttgt ggcgcctctt tctgttccgc caagttaaac agcatccgcc ctgtgctgaa 2806561 aataccactg ttgcatgaag acagcgcggc tgtcaacacg acaaagttaa tgatacctgc 2806621 ggccgatgga atgcccactt tttgaaatgt gagaacaaat ggacttcctt gagagccaat 2806681 ttcctgccac ggataaatag acataatgac aaataaagcg cctacataaa aaatcaaaat 2806741 ccgccaaaat actgtatcga ttgctttggc taacgatttt tgcgggtttt ttacttcgcc 2806801 agccgtcacc ccgatcattt caatccctaa ataggcgaac atgaccattt gaagagacaa 2806861 taaaacccct tttaatccat gagggaaaaa tcctccgttg ttccacaaat tgctgattcc 2806921 ggttgcaatg cccccattgc cgactcctgc aataatcatc aataaaccga cagcaatcat 2806981 ggataagatt gcaacaattt taatcaatgc gaaccaaaat tccagctcgc cgtaagcttt 2807041 gacagccagg aaattaacac ccgtcataat gaccagtgcc gataacgccc aaatccagtt 2807101 tggcacgtcc ggaaaccaga accccatata gatgccgaca gcagtgattt cggccataca 2807161 ggtgacaacc cataaaaacc agtagttcca acctgttaaa tagcctgcaa gcggtcccaa 2807221 ataatcacgc gcatacctgc tgaaggagcc tgcgaccggt ttttgaatgg ccatttcccc 2807281 aagcgctctc ataataaaaa acatgaccag gccgcttgcg gcatacgcta ccaaaatacc 2807341 aggccctgct aattgaatag ctgatgcgga gccgaggaac aaccctactc ctatagcagc 2807401 tcctaaagac attaaagaaa tatgcctttc ttcgagtccg cggtgcagct cttgtttttg 2807461 tttttgcatg cttcttctcc cctagaaaaa aatatcatta tatcattttt ctgaatattc 2807521 cgtacggatt gggtaaatca atgatgatgg agaaataaaa ggataacaac aaggctttcg 2807581 actactcgaa agccttgttg tctgttacac aaagatgact tctttaggct gatggctcag 2807641 ctcttcaggc atataccgtt tttcaatatt gatgctgtgc cagatcataa agattagcac 2807701 agtccaaatt ttacggctgt tatcagcctt gtccgcacaa tggtcttcaa gaagctgaag 2807761 gacataatcc ttatggatat aagcatccgt ttggctttct tgaataatat tccgcaccca 2807821 ttcgttcatt tcgtttttca gccaatgacg gatcggtaca gggaaaccaa gctttttgcg 2807881 gtttaatacg tgctcaggca caattccttc agcggctttg cgaagaagat acttcgtcgt 2807941 gccgttcttc gttttcagct catcaggaat ttttgaagcg acgtcgaata cgactttatc 2808001 caagaacggc acacgcagtt ccaaagaatt cgccatcgtc attttatccg cctttaacaa 2808061 aatgtcgccg cgcatccaag tgtggatatc gacatactgc attttgttga tatcgctgta 2808121 cgagctgctt tctgtaaagt aagtcttcgt cacatcgcga tatgaaaggt tcggattata 2808181 atgcttcaac agctgctttt tgacagactc ttcaaagatt ttcgcgttac cgatataacg 2808241 atcctgaagc ggagtgcagc cgcgctcaag caggctcttc cctctcatac cttcaggcat 2808301 aacggcagca acgtgcagaa gcatcttttt caagccggac ggaatccgtt caaacggttt 2808361 aagcgaaagc ggttcacggt aaatgttata tccgccgaag agctcatccg ctccttcacc 2808421 tgataaagca accgtaacat gtttttttgc ttcttttgca acaaagtaca acggaatcgc 2808481 tgccggatca gcaagcgggt catcaaaatg ccatacgatc ttcggaagct cattcatgta 2808541 ttcctcaggc gaaatgactt tgctgatatt ttcaatgccc agcgccgctg ccgtttcttt 2808601 cgctacatca acctcactga agccctgctg ttcaaagccg acagagaatg tttttaagct 2808661 tggatgaaat tccttcgcaa cagacacaat aaaggaagaa tcaatcccgc cagacaggaa 2808721 cgaaccgaca ggaacgtcac ttctcatatg aacgtttaca gagtcataga tcgcgtctcg 2808781 gacttctttc acaagcttgt cttcttcagt ctgaaccggc ttgaagttcg ctttgaaata 2808841 cgttttgaat gtgatatcgc cgtccgggcg gattgtgaat tgtgaacccg gctctacttt 2808901 tttcacatgg gcatcaagcg tgcttggttc aggaacaaat tggaaagaca tgtactgctg 2808961 caatgcctct ttatctattt caatatcatt ctgagcaacc attaaacttt ttctctctga 2809021 ggcaaaataa acctgatcat tgatcgttgt gtagtacaac ggtttaatgc cgaatggatc 2809081 tcttgcccca taaagcacat gatcgttttt attccaaatc agaaaggcaa acataccgcg 2809141 cagtttggac gccgcttctt ctttatagtg acggtaagtc gcaagaagaa cctctgtgtc 2809201 cgaatccgtg ttgaatgtgt acccctttgc ttcaagttct tctctcagtt cgatatagtt 2809261 atagatttct ccgttaaaga taatccaata tgtttcatct tcatatgata aaggctgtcc 2809321 accattttct acatcaataa tgctgagccg tctgaatccg aagccgacgt gctcatcatg 2809381 gaaatatcca tcactgtcag gaccgcggtg aacgatcatt tggttcattt gtttgattag 2809441 ttcttcttga tcagcggttt gagctaacgg atgcttgtta aaaaccccga caaatccaca 2809501 catagtattg cctccataat taaaattgtc atcattgaac ccctatttat agacgctgtg 2809561 aatagtattt ggtttcacag ttatgtaaaa aaataaacat gaatacaacg ataaaaaagg 2809621 gaaagccgct taaccagtaa gcggctataa aattattctc ctaacgcttc tttacgcagc 2809681 tgctccgctt tgtctgtgcg ctcccatgga aggtcaacat cgtgacgtcc aaagtggccg 2809741 tacgcagcag tttgtttata gatcggacgg cgcaaatcaa gcattttgat aatgccggca 2809801 ggtcgtaaat caaagttatt gcgaacaact tcaatcagtt tttcctcaga agcttttcct 2809861 gaaccgaatg tgttgattga gattgacaca ggctgtgcaa caccgatcgc gtaagcaagc 2809921 tgtacttcgc aagaatcagc aagctcagcc gcaacgatgt ttttcgcaac gtatcttgcc 2809981 gcataagctg cagaacggtc taccttcgtc gcgtccttac ctgagaacgc gcctccgccg 2810041 tggcgtgcat agccgccgta cgtatcaacg atgattttgc gtcctgtaag tcccgcatcc 2810101 ccttgagggc ctccgattac gaaacgtcct gtagggttga tgaaatattt tgtttcttca 2810161 tcaatcagct cttcaggaac aaccggattg attacatgtt ctttaatgtt gcgctgaatt 2810221 tgctcaagtg taatttcagg gtgatgctga gttgaaataa caatcgcgtc aatgcggact 2810281 ggtttgttat tttcatcgta ctcaaccgtt acctgtgttt tgccgtcagg gcgaaggtac 2810341 ggaagaatat cttctttacg gacttcactt aggcggcggg ctaatttatg ggcaagtgaa 2810401 attggaagag gcataagctc tttcgtttcg ttgcacgcat aaccgaacat taatccttgg 2810461 tcacccgcac caatcgcttc aatttcttcg tcgctcattg tgccttcacg ggcttcaagc 2810521 gcttggtcta cgcccatcgc gatatcagca gactgctcat caattgatgt taaaaccgca 2810581 caagtttccg catcaaatcc gtattttgca cgtgtgtatc cgatttcttt aatggtttgg 2810641 cgaaccgttt tcggaatgtc aacatacgta gaagttgtga tctctccgct tacaagaacc 2810701 aaacctgttg tcacagatgt ttcacaagca acacgcgcgt tagggtcttt ctttaaaatt 2810761 tcatctaaaa tgctgtcaga aatctggtca cagattttat ccggatgccc ctccgtaaca 2810821 gattctgatg taaataaacg acgattttta ctcatgattt gcttcctcct gcacaaggcc 2810881 tcccgaaaga ccttgtatat atgatacgga actcgctccc tcttatacaa tgtacagtta 2810941 tattagagaa tgttaattgg catatttatg aaataaaaaa accttttcca tcgaggaaag 2811001 ggtttggtct ttgtgccttt cactcttatc gctcaaggaa tcatacaacc ttgcaacagg 2811061 ttagcacctt ggttgtctca ctcagttgaa cataataaat aacagagaaa ccggttgctg 2811121 ggcttcatag ggcctgtccc tccgccagct cgggataaga gtatccgctc aatgaaatat 2811181 cttatcgtaa aagggtttgc aatgtcaata tgattcagaa gaaataggca cctatattga 2811241 gggaaaacaa tggaaatgca cacacaaaaa acaataaata gtatagacta tttgaaaata 2811301 tatgttatac taattcacaa ttagcaaaac acaaaaaacg ataaaggaag gtttcatatg 2811361 aactcagttg atttgaccgc tgatttacaa gccttattaa catgtccaaa tgtgcgtcat 2811421 aatttatcag cagcacagct aacagaaaaa gtcctctccc gaaacgaagg cattttaaca 2811481 tccacaggtg ctgttcgcgc gacaacaggc gcttacacag gacgctcacc taaagataaa 2811541 ttcatcgtgg aggaagaaag cacgaaaaat aagatcgatt ggggcccggt gaatcagccg 2811601 atttcagaag aagcgtttga gcggctgtac acgaaagttg tcagctattt aaaggagcga 2811661 gatgaactgt ttgttttcga aggatttgcc ggagcagacg agaaatacag gctgccgatc 2811721 actgtcgtaa atgagttcgc atggcacaat ttatttgcgc ggcagctgtt tatccgtccg 2811781 gaaggaaatg ataagaaaac agttgagcag ccgttcacca ttctttctgc tccgcatttc 2811841 aaagcggatc caaaaacaga cggcactcat tccgaaacgt ttattattgt ctctttcgaa 2811901 aagcggacaa ttttaatcgg cggaactgag tatgccggtg aaatgaagaa gtccattttc 2811961 tccattatga atttcctgct gcctgaaaga gatattttat ctatgcactg ctccgccaat 2812021 gtcggtgaaa aaggcgatgt cgcccttttc ttcggactgt caggaacagg aaagaccacc 2812081 ctgtcggcag atgctgaccg caagctgatc ggtgacgatg aacatggctg gtctgataca 2812141 ggcgtcttta atattgaagg cggatgctac gctaagtgta ttcatttaag cgaggaaaag 2812201 gagccgcaaa tctttaacgc gatccgcttc gggtctgttc tcgaaaatgt cgttgtggat 2812261 gaagatacac gcgaagccaa ttatgatgat tccttctata ctgaaaacac gcgggcagct 2812321 tacccgattc atatgattaa taacatcgtg actccaagca tggccggcca tccgtcagcc 2812381 attgtatttt tgacggctga tgccttcgga gtcctgccgc cgatcagcaa actaacgaag 2812441 gagcaggcga tgtaccattt tttgagcggt tacacgagta agcttgccgg aaccgaacgt 2812501 ggtgtcacgt ctcctgaaac gacgttttct acatgcttcg gctcaccgtt cctgccgctt 2812561 cctgctcacg tctatgctga aatgctcggc aaaaagatcg atgaacacgg cgcagacgtt 2812621 ttcttagtca ataccggatg gaccgggggc ggctacggca caggcgaacg aatgaagctt 2812681 tcttacacta gagcaatggt caaagcagcg attgaaggca aattagagga tgctgaaatg 2812741 ataactgacg atattttcgg cctgcacatt ccggcccatg ttcctggcgt tcctgatcat 2812801 atccttcagc ctgaaaacac gtggaccaac aaggaagaat acaaagaaaa agcagtctac 2812861 cttgcaaatg aattcaaaga gaactttaaa aagttcgcac ataccgatgc catcgcccag 2812921 gcaggcggcc ctctcgtata aaaaacaaaa gccaagagca attatgctct tggcttgttt 2812981 taattgacgg aatgcaaaga agtcagcttg tatgtaatga tggtccggcc ttcttcccat 2813041 tgaagcttct gcacttcagc tgtgcctgac ttttcgccaa actttgtttt gcgtacatcc 2813101 attggaatct ccatcggata tactcggtat ccgtccttct ctaacgtgaa tatattttca 2813161 tctatgcgaa cttcttttcc ttttgtcaca atcagtgtat taaattcaac aggcattccc 2813221 aaagtgaaat cccctttcgt tctctttttt ctttatcata acatatttca ctgtcagcgg 2813281 tttttcatcc attgtgtgag ctgccgcacg atacgccggt tttcttttgg cgggaaataa 2813341 tgtgtgaatg tactgtagta ccatgtttcc accggcttat gcagttgttt tagcttctct 2813401 tctaataaat aggaatgctg aatcgaaaca ttttggtctt tttctccatg gattaacagc 2813461 acgggagcct gaattttgtt tacttggtca aacggtgtcc tccattgata ttcctcaggc 2813521 acctttttcg gtgttccgcc gatgactctt ttcatcattc gccgcaaatc ctgccgctcc 2813581 tcgtatgtaa gaatcatatc actgacgcct ccccaggaaa caaatgaagc tgcctgcccg 2813641 cccatttcga tcgcagtgag cattcccata attccgccgc gggaaaaacc gaagatatgg 2813701 attctatcct tcttgacatt tgggtgctgc tgaagcaggc gaaaagcaga aaatgcatcc 2813761 tccctgtctt ctccggcaaa atcctcattg ccttctcctc cttgattgcc tctgtaaaaa 2813821 ggagcaaaca ccacaaaccc ttgggatgca aactggataa tccggcccgg ccgaaccatg 2813881 cccacgcttt taatcccgcc gcgcaaatat aaaaatccgt catattgtcc cggttccgcc 2813941 ggctcagcca gaagcccctt aacccgtaat ccatttgaca gatagcagat cgtatacaaa 2814001 cgcacatgct ggcttggcga cggaaatctt cttttctcta caatcaaaac agccgcctcc 2814061 ttttttctat atgctttcct tactccaaaa ttacatccgg agaacctggt taggcattca 2814121 cacattttta tacccatcat acgatatgta aagcaaaaaa ggatattaac ttgatgcgaa 2814181 ataaggaggt tgtctatgtg aacagatggt taaggctggg cttcgcctgt gtcggcagta 2814241 tctttctgat gttcgccctg gcggcttgca agcaggaaga aacgctcacc aaagtcaaag 2814301 tagctgaagt gacccattca attttttacg cacctttata tgttgctgag tctaaaggtt 2814361 tttttaagga agaagggctt gatgtcgatg tgaatacgac ctggggcgga gataaaacga 2814421 tgacatcgct tctttccaac ggctccgaca tcgcgcttgt cgggtcagaa acatctattt 2814481 atgtcgaagc gcaaggggct aaagatcccg tcattaattt cgcccagctg actcagacag 2814541 acggaacgtt tcttgtcgcg agagaagatg ttgaacactt cgactgggat cagctgaaag 2814601 gaaaaacgtt tctcggtcag cgaaaaggcg gcatgccgca aatggtcggc gagtatgtac 2814661 tgaacaaaca taagattgac ccgcataagg atatagacct catccagaac atagacttcg 2814721 ccaatattgc caatgcgttt gcttctggaa ccggtgagta tgtacagctc tttgaaccgc 2814781 aggcttctct ctttgagaaa aaaggcatcg gccatatcgt ggcttcattc ggagaagaat 2814841 caggagaggt tccttatacg acttttatgg cgaaacaaag ctatttgaag aaaaatgaag 2814901 acacagccgt caagtttaca aaagccattt ataaggcgca gcagtgggtt gaaaatcatt 2814961 ctgcgaagga catcacagat gccattaaag atgaatttga tgataccgac ccagacgtca 2815021 tcgaaacatc cattgaacgc tataaaaaac agcattcata ttcaccagac cctctgctta 2815081 acgaaaaaga atgggagctt ctccaaacca ttatggataa atcgggagaa ctgccgaagc 2815141 acattccata caatcagctt gtaaataaag aaattgctga aaaagtcacc tcggagaaat 2815201 aggaggcgcc atctatgtct ttcttacatg tcgaccatgt aacccatact tatttttcta 2815261 ttaaagaaaa aacaacggct gtgcgggata ttcatttcga tgccgaaaaa ggcgatttca 2815321 tctcatttct cggcccaagc ggctgcggaa aaacaacatt gctttccatt attgccggtt 2815381 tgattgagcc atcagaaggc agagttctga ttgaaggccg tgagccgaat caaaaagaac 2815441 ataatattgg ctatatgctt cagcaggatt acttatttcc ctggaaatct atcgaggaaa 2815501 atgtgcttct cggtttaaaa atcgccgaca cgctgacaga agaaagcaaa gccgctgcac 2815561 tcggtctatt gccggagttc ggcctcatag atgtggagaa aaaatatccg aaagaactgt 2815621 caggcgggat gcgccagcgg gctgcgcttg caagaacact tgcgcctaac cctagtctgc 2815681 ttttgctgga tgagccattt tccgcgcttg attttcagac aaagctgtct ttggaaaacc 2815741 tggtattccg cacattaaag gaatatcaaa aaacagcagt gcttgtcact catgatatag 2815801 gggaagcgat agcgatgagc gatacgatct ttttattttc aaatcagccg ggcaccatcc 2815861 atcagatttt taccattcct aaggaattgg ccgcgatgtt gccttttgac gcccgtcagg 2815921 aaccttcctt ccagacactg tttcaaacga tatggaagga gctgaattct cttgagaaac 2815981 agcaaagaaa ccattgatct gcttcacgag cagtatcaat tcaaacagaa aaaggaaaag 2816041 tggaaggtcc attcctttca gcttgccata tttattctct ttttctcggg ctgggaaatc 2816101 tccagcaggc agggctggat cgatccgctg atcttcagct ctccatcagc tgtgtggcga 2816161 ttattgctgg agaaacttgg tgacggttct ttactgtcac acatcggcgt cactttattt 2816221 gaaacggtgc ttggcttttt gctcgggacg tttatgggca cgtgcctagc cgctttgtta 2816281 tggtggtcta accgacttgc cagaatttta gatccgtatc ttgtgatttt gaacgcaatg 2816341 ccgaaagtgg ccctgggccc gatcctgatt gtcgcgctcg gtcccagttt tatcagcatc 2816401 attgcgatgg gagccatcat cagcgtcatt atcacaacca tcgttgtcta caccgccttc 2816461 caagaggtcg acgaaaacta tacgaaagtc atgaaaacat tcggcgcaaa aaagtgggtt 2816521 atttttaaag aagtcatact gcctgcatcc tcccccgcga ttatttcaac actaaaagtg 2816581 aacgtcggtt tatcatgggt tggcgttatt gtaggggaat tcctcgtttc gaaggtcgga 2816641 ttaggatata tgattattta cggattccaa gtcttcaatt ttacactcgt cttcttaagc 2816701 ctgctgatca tcgccatctt cgccactctg atgtatcagg gcgtcgagct gctggaaaag 2816761 aaatggacga aggggaggac ataaaaaacc cggcacatgt gccgggtttt ttattcaatc 2816821 catccagatt ctttcagttt tttcaagctg atcggaagaa cggaatcctt cataataaag 2816881 ctgaattttt tattgcggga aaggttctcc ggcagctcgt gaaacaaaac cgggcctttc 2816941 gtttcaaagt aatcagcctg cttttcaagc ttttctatat ctgcaaaata tatatttttt 2817001 acaatcactt tttcttttcc gagaacttta tactgtccga gatacttgag gcttttgact 2817061 ctcgcgcccg tctcttcctt tacttcccgg agcgcagcct cttctgcgca ctccatcggc 2817121 tctactttcc cgcctggaaa ctcatagcct ctgtcctcat gttctgttaa aagccatttg 2817181 ccgccaaaac ggcaaatcac ccagacatgc ttcgggctgt ccgagaaagg ctgatcgtca 2817241 aaggaaagct gaacagtatt ctgataataa tctttaaact cgtacatgtt tatccctcaa 2817301 atccgttcct agctatcttc catacatcat accacagtta cgtttcttcg gaagcctttt 2817361 atcaaaaaat aagggaaacc cagcacgccg tcaggttctg catgcagact agctcgtaca 2817421 gtttttttgc gatacttttg ccggaaagtg cgaccgacgc tctgggcttt attatgaccc 2817481 gcgaacaggg aaaagttacg gtttgcgctt aaatttattt tttaacgttt ctaaaagatc 2817541 gacaagcatc tgaggaaccg gtatgccaag agagctggct gtcacaacaa tttgcacaga 2817601 ttcataaaga atataaaaca taatagccaa gtcacgaatt gatccctgtg tattcagcag 2817661 ctgatcaaaa aagtggcata cagagatcag agccagcgtg actaattttt tgacaagccg 2817721 ggcaaatacc tttttaaatg acagtttgtg aataatggtt tccttcaaag tcgtactgat 2817781 aaattcaatt gccataagag agagcaaaat cagaaatgaa tactgaaaac ctccaaagaa 2817841 aaaacccgct gctgaaacgc tgactgctaa aaacgaaaag atgccaaagt ctctatccat 2817901 ttatcccaac atcctttcac agaaacggcc ttacgatatt ctatggtaaa caagccgaac 2817961 ggattggatt tttcagaaaa atggactggt tgtcgcctat ttttcagata caaaaagaaa 2818021 agccggacgt cttttttaag acatccggcc gttctatttt tgaacttaac ctaggtaagc 2818081 ttttagcatc cagttatgtt tttcaatatt ttgatggatc gcaagaagca tgtcccctgt 2818141 tgtttcgtca ccgacttcat cagctaaatc catgccgttt ttcagctctt ccgcgatgac 2818201 tgtgaaatca tcatatacgc tttgaaccat ttgttcagct gtttcatttc cagcagcttc 2818261 tttgacagaa gccgtttcta aggattcctt cattgttgca atcggttttc cgttcagcgc 2818321 caaaagacgt tctgctaagt catcaatata agttgctgtt tcgttgtaca gctcctcaaa 2818381 cttttcatga agagtgaaga aatctttccc tttcacatac cagtgataat tatgtagttt 2818441 cacatacatg accgtccagt tggctacttg tttgttcact gcttgaatca attgttctga 2818501 catggtatct cctccttgtt atatgactat gtataccctt aatatcgtac gctaaaacct 2818561 cttttttacc cttatctgtc acgatttctt ctattatgct acaattgtta aaaaacggga 2818621 ggtggaatgt catgacgctt ctcattacga taagtatttt gattgtgctg gctgttttgc 2818681 ttgtaaccat ttggacgact gtaaaagcct ataatgtaaa gcataccatt gatccaccac 2818741 aagaaaatca ctctgattca cacaatcaat gatgatgtga atgctcctct tctgactgat 2818801 tgctggcagc atcggcgtct ccgacttgga cttttaaggt cggcatgcta tgctgttttt 2818861 ttgctgtgac atgagattgg acagtgtata caccatcttc cttaaacgtc gtttccaatc 2818921 ggtatacgcc tttttcttgt ttcaccttaa acatttggct tgcgtctttt tccccttctt 2818981 tccatacttc aaactctact tcatcggcat ccgtcacagc ttcatcacca tatgatacag 2819041 ctgcttcata agcagcgctt tctccgggat ttactttttc aggcccggtc agcttgacat 2819101 ccaaaacctc gggcgtctca gctgtatttg ctttactttc accagatccg catccattaa 2819161 gcaataaagc agaaaaaagc agaacaacca acatcttttt catgccatca ccctttcatc 2819221 gtttacctaa atagtagcaa acgcttacag caaatggtac acaaaatatg agacgtcaca 2819281 aaaaagacct ttttgcttaa gcgcaaaaag gtcctttcta ttttagccaa atacttttag 2819341 caattcttct ttatcctgtg aaagccagaa acgcattaaa cgtttagcgc cttccagatc 2819401 atgaagcttc gcttggccgc actgcttttc attcgcagca ggtatttctg taatctctac 2819461 cgcttccttc attgtgtctt caagcagatc aacgatttcc gctgatgtcg gctctccgct 2819521 cacaactaga taatagcctg tctggcagcc cattggagaa atatcaatga tatcaaaatg 2819581 atcgtatttc tcagcgtgag aacgaatcgt aaacgcgagc aaatgctcga gtgtgtgaat 2819641 ggtgtcaggc ttcatcgcct gtttatttgg ctggcaaaaa cgaatgtcaa atttatttac 2819701 aacgccgtct gttcccactt tatgcacgcc gcaatgtctt acatatggag caacaaccgc 2819761 attatgatca agctcaaaac tttctactga aggcataatg gcactctccc cttttttaaa 2819821 aatgtaattt cattataaca tacttttccg ataagaatta ttgattaact tttcaatctg 2819881 tgtttttttt cttatacttg catcagaaag gttgctgaag aaacatgaaa accctattca 2819941 tcgctctgat cagaggatat caaaaattca tctcgcccct gacaccgcca acgtgccgct 2820001 tttatccgac ctgttcccaa tatggaatcg aagcgattaa aacacatggc gctttaaaag 2820061 gcggatggct gacaatcaaa cggattttga aatgccaccc gttccatccg ggaggagtcg 2820121 atcccgttcc tgaaaagaaa caaaaacatt aattgttata accgtttacg ataagatcca 2820181 gttttccggt tttaggatca atgactaagc catggaccgg aacgttttca gggaacagcg 2820241 ggtgatgttt aataacatct acgctgtctt tcacactcgc ttccactgaa tcaaagcttt 2820301 taaaccattg atcaaagtct acaccggagt actttattgt ttcgatgcgt tcttccggaa 2820361 tccctcttgc tttgattttt tcaagcatgc ttttgctgct gattttgctc atgccgcaat 2820421 cgtgatgccc gatcacacac acctcatctg cattcagctc gtacactgcg acgagtatac 2820481 ttctcatgat gcttccgaat gggtgtgtca caagcgcacc ggcactttta atgattttca 2820541 catcaccgtt tcgcaaattc atcgcatgcg gcagcagttc aaccagacga gtatccatgc 2820601 aagaaagaat cgccattttt ttatctggaa attttgatgt ttgatacttt tcatactctc 2820661 tttgttcagt aaatgtcttg ttaaattcga gaatatcatt tagaagactc atgttcgttg 2820721 tccctttcta ttctttttac tcttcaatat atcacaaccc ttgtttattc gtcataataa 2820781 aaaaagacaa accctcaggc ctgccttatt tccccatgtt atagcgtttt ttgaactgct 2820841 caactcgtcc gcctttttca ttgaatttct ggcggcctgt ataaaacgga tgcgtgtcag 2820901 agcttacctc tactttaatg acaggatatg tgtttccgtc ctcccactct gctgtttcat 2820961 tagatgtttt cgtagaggtg cttagaaaac ggtagccgct gttgacatcc tgaaatatca 2821021 ctttgtggtt ctttggatga attccttctt tcatgggtat ctcctttcaa taaatcgtaa 2821081 taattacgtt ttattttata accttacaaa cgttttgtca atcttcttat atccttccct 2821141 ctgtttcaca tcgtaaacct catggcattt aagaatagga agaataatct aaccgaggaa 2821201 gcaaataata aacccaaaat acatacagaa cgtctttttg gaaaggtggt ttacgattgt 2821261 ggatgattta gttttggcca gaagcctttt tggcacgacg atgggctttc atatcatttt 2821321 cgcaacactt ggagtcggtc tgccgctcat gattttagtg gcggaattga tctatcaaaa 2821381 aacgaaagat gaccattatg cgatcatggc gaaaagatgg acgaaagcac aagccgtttt 2821441 gctgggggtc gccataccga ccggaacgat cgcgggcact cagctcgcgc ttttatggcc 2821501 gggatttatg gaagtcatcg gccgggtgat gtccctgcca tttcaaattg aaatctatgc 2821561 tttttttgtt gaagccctat tcatgtcgat ttatgtatac gctgcagacc gtttgtcacc 2821621 tgcaatgagg attgttgctg ttttctttgt gttagtcggg gcagcagcat ccgctgttct 2821681 gatcacgaat gttcacgctt ttgaaggtac gcccgccggt tttaaaattt taaacggaaa 2821741 aattacagat gttgacccgt gggctgcgtt ttttaatcct agctttttta tcactgccgg 2821801 ccatgtcgtg ctgtccgcgt ttatgactgg tgcgtttatc gtggcttctg ttgcggcgta 2821861 taaaatgatc cgaacgagga aaaaggaaag ggtctatcgc tttcaccgga aagccctttt 2821921 gctcgcactg acgatcggcg gtattttttc attgctgacc gctttgaacg gacacgaatc 2821981 tgcacagatg ctgtacgaat accagcccga aaaattagcc ggtgcggaag gcctatttga 2822041 aacaagatcc cacgccccgc tcgctatcgg cggttttacc gacccgaatg aagaaaaagt 2822101 aaaatgggca atcgagattc catgggcttt aagctttttg gcagcgaacc gttttgacac 2822161 tgttgtaaaa ggattaaatg catttccgag agatgaatgg ccgccgcttt tcattcacac 2822221 gctgtttaat gcgatggttg gtgtaggcat gctgctaatt ctttattcca ttatcggtgt 2822281 ggtctggaga aaggtgctca agaaagaccg tttcccaacg tggcttttga tcattttcat 2822341 gacagcaggc ccttttagtc tcatcggcat tgaattcggc tggattttcg catgtacggg 2822401 gaggcagcct tgggtcatct atcatctgct gaaaacgtca gatgtcgtaa caacgactgg 2822461 ctcgatcggg gtgctgttct tatttttcac atttgtttat gccgtgttag gcgcagctgt 2822521 cgtctacgtg ctgctgtatt atttccgcaa gcacccggtt gacgaagatt taaatacagc 2822581 ggagtcgtaa tggctccgca aacaggaaac caaatggaag gaagatcgta caaatggaga 2822641 tttcaactga cgctctgatc gccatctcaa ttatctgggg ctttgtgttt atttacgccg 2822701 tcatggcgac aatggatttt ggagcgggat tttggtctat gatctattta aacaaggagc 2822761 atatgaaggc caccgatatt gcgaatcgct ttttgtcccc gacttgggag gtcacaaacg 2822821 tctttattgt ggccatcgtc gtggcgcttt tcagtttttt ccccggcgcg acatttgtgc 2822881 tcggcaccgt tttattaatt cccggaagca tgattttgct gcttttagca attcgaagcg 2822941 gatttctcgt gttttcaaat acagcaaagg agcggaaaac gctaagatat atttccggca 2823001 tctccggctt tatcattcct gctattttaa ttttggtgct tcctgtgaca cacggagggt 2823061 ttatagaaaa aacggatgga atctataact taaatatgtc taaaatcttt tcaagcccca 2823121 acgcctattc atttatcggg tttgcgattt taagcacctt atttttgtcc tcgctgttgc 2823181 ttgcagattt ttcaaatgtg gcagaggaac aggatgcgta ccgagcctac agaaaaagcg 2823241 ccctgattac cggcccgatt tcactgttgt ttgctgtatg cattatggta actatgcgga 2823301 atgaagcaaa ctggctgtac agcggaatga tgaatgattt ttcttggatt attgcatcgt 2823361 tcattacatt tgtcattgct ggaatcgctc tttttctgcc taacaaaagc tttggtcaaa 2823421 acatcggaaa accgcgtctc gcacttgttg cgattgggat acagtatttt ctcgcaagct 2823481 acgcgtacgg gcgggcgcat cttccgtata tgatttatcc cgatgtgaca gtcatgtcag 2823541 gcttcacaga gccagcaacg ttcagagcgc tgtttgcaac gtatatcgtt gcatttatca 2823601 ttctatttcc gggcttcttt ttcttctgga aaatgtttat gcgagataaa cgctatatcc 2823661 gccaggagga atagagggca agccagccgg ctatactaat ccagaacctt tataaggagg 2823721 ggatggcatg gagcagaaaa ttctatgtga ggtcaacaac tgttcttatt ggggcaaagg 2823781 taacaaatgc accgctgatg ccatttatgt tgtcagccat actggtgaaa cggctgaaaa 2823841 cagccgggaa acagactgca aaacgtttaa gccgcatgat ttataattaa aagaaagagc 2823901 tgcatcagcc agctctttct ttttgcatgt tgagtgttct cagcttttta gttatgaccc 2823961 cgtttgcagg tgaaaacaaa aaggcgcttg cataacatac acctgtcatg gccgccatcg 2824021 ctcctgaaat cgaaacatta agccacgttg cgaagaaata gcccatgacc gccgacagcc 2824081 cgccaatcaa cgcgctgaga atcagcatat aaagaagccg gtctgtcagc aaatgtgccg 2824141 cagccggcgg aacaatcagc atggccacaa ccaatacggc acccaccgaa tcaaaggaag 2824201 caacagtcgt caaggacagc atgcccattt gcacgtaatg aatgagcaaa accggtattc 2824261 ccaaggctaa agccatttga ggatcaaacg aagcgatttt aaactcctta tagcacacac 2824321 tgatcaacac tacgtttaaa accagaacag atgccagcat ccaaaacgct ttcggcccaa 2824381 tatcaacccc gaataccgtc accgtattcc acggcacaaa agcgatttct cccattaacg 2824441 agtgctcaat atcgagatgg acattcgctc catacacaga aagcaaaata accccgattg 2824501 caaataagga tgtaaacaca actcctatgg cagcatctga ttgaaccccc ttgctatgaa 2824561 gaagctgaac caagaaagcc gttaacagac cggttgcggc tgcgccaata aacatataaa 2824621 tcccatcgag acttcccgtc actagaaaag cgccgacaat gccaagcaac actgtgtgac 2824681 tgattgcgtc ggccagcatc gccatgcttc tcagcacaag aaatgtgccg atcaatccgc 2824741 agcttacacc gactaataca ccggtagcta taatccatgc ttcaaaactc atttgcgatc 2824801 tgtcccttct cggcatcatg agacgctttt cgacgctcag gcatccgtcc atacagcttt 2824861 aagagtgaat aaagccgctc tctcgtttct ctcggtaaac ggtccgggtc aaagtagtcc 2824921 tgatcggatt ctatattggc aagttccatt tcatgcatga gatacacttc atacatccgc 2824981 tgcttcaaag ctgtgtgata gcctttttct atccctttgc ttgtgatttg ccaaatccca 2825041 ttttcgatac gctcaatgca cctctcttgt tccaagtcat ttaatgcctt aaggcataat 2825101 gaaggggata ggcgtctttt ctttcttaca ctttcaacag ttacacaaag attattcttt 2825161 tcatactgtt cataaatcgc caaaagcact tgctccctgc ttgttctgcg ccgcagcctc 2825221 atcagcctta tggctttagc agccaatccc cgcttaggcg cgcaaatcat tgaaaaaaga 2825281 aagagcagcg ttgcagataa gatcattaat ggccctgtcg ccattccctt catcgtggtg 2825341 ctaagcaggg ttccggccac tccgctgacc ccgcctgtaa tcccggcaat gatgatcatc 2825401 ccggttaatc gttcggtcca atatctcgcg gttatggcag gtgtaatcag catagccgcc 2825461 attaatatca caccaacagt ctgaagccca atgacgacag cacagacaat cagacaagcc 2825521 aaaagcccgt ttaaaaaacg caccgggatt cctaatccct ttgcaaacgc gagatcaaaa 2825581 gtaatcaatg taaattcctt aaagaaaaca atacatagga gcagtagaac agcggatatc 2825641 cctgcaataa ggatgatatc ctgcctgacc aatgaagcag cctggccgaa taaaaaagaa 2825701 tcaagcccgc tttggcttcc cgccccctgt tgctgaatat atgtcagcag aatgatcccg 2825761 acgccaaaaa acacagaaag aacaatcccg atcgccgagt cctcctttgt ttttgaaagc 2825821 cgaggaatca gctgaataca aaacgttccg agcagtccgg cgagcgctgc ccccagcaaa 2825881 aagaaaggca gtgatttttg cccggtgaac agaaaagcga gacacactcc cggcagagct 2825941 gaatgggcca tcgcatcgcc gattaaactt tgctttctca gcagcacaaa gctgcccaaa 2826001 acaccgcttg ccgtcccgag caaaagcgta ccggccagca cccactgtgt attcggatgc 2826061 tgaagctgca gccacaaact ttcaaacatt gcgctcactc cttatgtcct tctgccagca 2826121 ctttatcttt taaaaacgta agccttcctc catatgtttt ttgcaggttt tcgatcgtaa 2826181 aaacgttttc cgtcggtccg aaagcgattt tccttaaatg aagcagtaag atccaatcga 2826241 aataatcctc ggcggtctgc agatcatgat ggacgacaag cacggttttt cctttttctt 2826301 tgagttctgc caacagcgtc ataatcgcgc gctccgtcgc tgcatcaaca cctgcaaacg 2826361 gttcatccat aaaataaatg tcagcgttct ggcagagtgc ccgggcaaga aacacccgct 2826421 gctgctgtcc gcctgacagc tggctgattt gccttttcgc ataatcatgc atcccgactt 2826481 ttgttaatgc ggccttcgcc atctccacat ccgctttctt tggcctcttt aataaaccga 2826541 ttctcccgta tcttcccatt aggacgacat cgagcgggct tgtggggaaa tcccagtcaa 2826601 ccgagccgcg ctgcggaaca tatccgattc tggtccgctg atccttatag tctttgccgt 2826661 aaatagagat gtctccggaa gctctgggca caagaccgag aatcgttttg atcaaggttg 2826721 attttcccgc gccgtttggg ccgataatgc caataagttt tccttcaggc acctgcagcg 2826781 aaatgtcctg cagtacaggc tttttatgat aagcaaccgt cacattatca agctcaacag 2826841 ggaacatatc ctccacctct tttctttatt taagcgcttt agtaatcgtg ttgatattgt 2826901 ggcggaacat tccttcgtat gtgccttctt ttgtgccctt ttcacccatg gcatccgaat 2826961 aaagctgacc gccgattgtg actgtatggc ctttttcttt agcgccttcc accactgcat 2827021 tgattgattt ttcagataca ctgctttcta cgaacacagc ttttatttgt ttttctgtca 2827081 gaagatcaac cagctcctga acatccctta atccatagtc cgaatctgtg ctgagtccct 2827141 gcaggccttt taccttaaat ccatactcat tcccaaagta cgcaaacgca tcatgagcag 2827201 tcacaagcac acggcttttc tccggaatat gtgcgatctc cttacgcgac cacttatcta 2827261 aatattgcaa atcttctttg tactctttgg catttttccg aaaggcatct gcgtgctgag 2827321 gcattgcttt gctgaattgc gcttcaattt catccaccgc atagatccat aacggaatgc 2827381 tgaaccagac gtggggatca aacgtcttgc cttcccccgc gggaataagc ttatttttcg 2827441 gaatggcctc agctactgcc gccgattgtt tttgttcgcc gattttttgg aggacatcct 2827501 ccattttccc ttccaaatgc aacccgctgt acagaacaac atcggcagac attaattttt 2827561 tcgtgtcacc ttgggaagct ttgtaaaggt gcggatcaac ccccggtccc attaaagagg 2827621 tgacttttac gtgcttacct ccgatgtttt ctgctgcatc ggcaatttga gatgttgtcg 2827681 ctgtcacttg taattgctga tcagcgcttt ttccggctga atccgttccg catcccgtta 2827741 aagcaaaggt cgcaaaaagt actgctgcca tcagcccttg tctcatattt ctcctcctct 2827801 ttgccatcaa tgtccgattg ttttatctta tgttgtcagt tcttagacat gtgacattaa 2827861 attagccaaa agcatgtttt atttacacag gacaaaaagt ttccctcatg caaaattatc 2827921 gcgtttggcc atttttgtca agctgattta cataaaaaaa ccggctgggt cagcagccgg 2827981 tccaaacgag aagggatgta ttcaacgaac acttttactg taacagcaca gtgtcattta 2828041 ttcaaaatag caaaatgctt ttttcttaac catgctgtgt gaaaacatcc attttggtca 2828101 catattttcg cataatatct tggtttacct caacccctaa accaggctgt tttgacacag 2828161 aaataaatcc attatcaata cgaatatcag gagttacaat atcttcatcc caatagcgtg 2828221 aggatgaaga tatatcgcca ggtattgtga attgaggcag tgaagcaagc gccacgttct 2828281 gcgctcttga tatgcctgtt tccagcattc ctccgcacca aacctgcata tgatgctctt 2828341 tgcataaatc atgaattttt aaggcttctg ttaagccgcc gacacgagaa ggttttatat 2828401 taataatttt gcagcttcct agctcaatcg cccgtctcgc atcatcaact gaacaaatgc 2828461 tctcatcaag gcaaatggcc gttttcaaat gtttctgcaa gtggcggtgg tcaacgatat 2828521 cgtcagcttg gagcggctgc tcaatcatca ttaaatgata gtcatcaagc tcctttaaac 2828581 ggctgatatc cttcagttcg taagaggaat tggcatcggc cataagcggg atggttggga 2828641 atcggctgcg gatggccttg accaattcca catcctgccc aggctgaatt ttaattttta 2828701 ttctttgata accttctttt tgatagctct caatttcctt cagcatatcg tcaagaggcg 2828761 ccaggccgac taccaccccg gcagggactt tatctcttgt tccgcccaat gcctcagcaa 2828821 gggatacgcc cttctttttg gcataaatat cccatacagc cgattcaagt cccgcttttg 2828881 ccatccggtt tcctttatac cgcgccaggc tgtccggcac ttctgaaggg tgattgaatt 2828941 cacggccgac gacatttggg ataaaaaaat cttttagcat atgcaaacat gttccaatgg 2829001 tttcctcggt gtaccaaggc gaagagaaag cggaaacttc tccccagcct gtgacacctg 2829061 atgtatcaat ggcttccacg atcagaaatt tacgctcttg aagcgtttcg atactgtttt 2829121 taaacggttt ctttaagttc atgctcaaat ggtaaagcgt gattttttct atttcgatca 2829181 tagcagttct cctttacgcg catccttcag ctgatttcgc aagagcttat tagacgcatt 2829241 gcgcggcagg cggtcaagca caaagaattt tgccggaatt ttatacttcg ccaagcgttc 2829301 tttgcagtag tcagtcaatt ctcctgcgct cacaggcttg tgaaggacaa gataggcgtg 2829361 aggcactttc ccccattttt tgtcctcagc ccctgaaacc ccggcttcgg ccacagcggg 2829421 gtgtgaaagc agcactgact ccacttcggc cggataaatg ttttctccgc cggatatgat 2829481 cagatctgaa cgtctgtcta atacatataa aaagccttca ttgtccaaat aaccaagatc 2829541 acctgttttc agccagccat tttgaaagga ggcttcgttt gcgctctccc ggttaaaata 2829601 gcttttcatg acattcgggc ctttgaccat gatttcaccg tgttcatacg gttcacatac 2829661 ctgtccgtcc cgctctattt tgatttcaca cgaaaacagc ggtttccccg cagatccgag 2829721 cttttccatg ctgaattccg gcgacagggt aacaatttgc gagcatgttt ctgtcattcc 2829781 atatgactga aagacaggga atcctttctc acggcattcc tcaagcaatg gcagcggtgc 2829841 aggaccgccg ccgagaagaa tgcatctgat ggattcaggg cagcggtttg tttcttccaa 2829901 aagactggcc agcatagtct gcaccgcaga tatcattgtc acttcatgcc tgttgataga 2829961 atgcagcaca tcgcttacgg aaaaacgctg gtgaagcacg acagtcattc catagatcac 2830021 agatttaaat aatgcggaca atccgctgat atgaaagagc ggcaatgcga taagccagcg 2830081 gtcttgttct gttataccca aattaagagc ggacgacacc gcactgaaat aatggtttcc 2830141 gaacgtttgc tgaactccct tgggctttcc tgtcgtaccc gacgtataca tcagcgttgc 2830201 cgttgcatcc atttgcatat aagcctcgat ctcaatttcc tctgctgctt ctttcatcag 2830261 ttcatccaca tcaatcgttt gaacgatgtg ttcatattct ttcttctcaa agcttgaatc 2830321 tgtcaataaa aagccggatc ccgaatcctc cagctgaaac agcctttcat gtgttgacag 2830381 cttcgtattc aaaagcaccg ccttaacacc aagcaaaaaa caagcgtgaa cagcgtatac 2830441 catttctgca cggttttgga gcaaaatagc tgcagtatcc cctttccgaa ccgaatgagc 2830501 ggcaagctgt tccgccattc gtttagacgc ggcaaacaat tctgcaaatg tcacggtttg 2830561 gtcttcatag atgagagcga ttctctcagg tgtcagctgt gcccgctgca tgagccagtt 2830621 gggctgttct gtcagcatgt catcatctcc gaggtaaaat gtctgtattg aaaagaaaac 2830681 agcttggacc gcaaagtctc aagctgttgg tttactagat attgctgatc acggaaaacg 2830741 agggaactgt ccgaaatcag gtttgcgttt ttccttaaag gaatcacggc cttcttttgc 2830801 ttcatctgtt gtgtagtaaa gaagggtagc atcccctgca aactgctgaa ttccagcaag 2830861 tccgtctgtg tccgcgttaa acgcagcttt aagaaagcgc agtgcggtcg ggcttttttc 2830921 aagcatttct tcacaccatt taatcgtttc ttcttcaagc tgttccaaag gaacgactgt 2830981 gttgacaaga cccatgtcca gtgcttcctg tgcgttgtac tgacggcata ggtaccagat 2831041 ttcacgtgct tttttatgtc ctacaattcg agccaggtag ccagaaccgt aacctgcatc 2831101 gaagcttccc actttagggc ctgtttgtcc aaaaattgcg ttgtccgcag caattgtcaa 2831161 gtcacatacg atgtgaagca catggcctcc gccgatcgca tatccggaca ccatcgcaac 2831221 aaccggtttc gggatgacgc ggattaaacg ctgaagatcc aatacgttaa gacgagggat 2831281 ctggtcgtct cctacatatc caccgtggcc gcgcactttt tggtctccgc cagaacaaaa 2831341 tgctttgtcc cctgcaccgg caagcacgat aaccccaacg ttttggtcgt ctcttgcgtc 2831401 agcaaacgca tcaatcattt cagcaaccgt tttaggggta aacgcattat gtacctcagg 2831461 tcggttgatt gttatttttg caatgccatt atacgtttca tacaatatct catcgtatgt 2831521 ccgttttgtt ttccattcag ccatatgatg acctcctttt attctctatg tgaatgagtc 2831581 agatgcttgt caaaaactca ctcactattt taccaaacaa tcgcggctgc tccacatgga 2831641 ccgtatgtcc tgcttttgga acaatctcta ttctactaga aggaagcatc ttatgcacct 2831701 cttgattgat ggcgcaaaat ttttcgtccc actccccgca gatcagaagc acaggaacat 2831761 ctatttcctc tacacggctc cacaaggaag gctgtgaacc ggtgcccatg ccggttaaac 2831821 tgttcgcaag cccaatctta ttgttccgca gacggcccga tcgtatcctg taccgaatat 2831881 cttcagccag cctctgctga gatgaaaaca aagggatatt ctcccaatac gcaacaaacg 2831941 cttcgagccc gtctcgtaaa ataaaatcag caagcttccg gtcccgcatg attcgttccc 2832001 gccgttcccc aagtgttttg agccccggcg tcgtgctttc aagcacaagt gccgataccc 2832061 gctcgggata tgtcatcgca aaagagtaag caagccttcc tcccatagaa tacccaatca 2832121 atttcacttt gtgaagtttt aattgatcaa aaatctcggc aaggtcagaa acttgccggg 2832181 ttgtgctgta tcttttccca ttcagcgggg catcggtttc cccatgccct aaacaatcaa 2832241 ttttgatcaa acgggaatca ggcagcattt catcaagaaa agtccatgat tgtttgctgc 2832301 cggtaaaccc atgcagacag acgacggctt cggaagcatt cggtccctcg tctgccactg 2832361 catatcggac accatctgat accgttatgt ttacagttcc cattgttttt tcacttcccg 2832421 cacagcctca ttcagcatat cgcgatgaag ctggactctt gattggcgat ccgttttgat 2832481 ttcaatcaaa tggagtccgg gcttgtctgc ctgcggcgcg taagctgttt tgaattcatc 2832541 ccaagaagcc gggcatgaat acgttccgcc gtaaagtgca gccgcatgct tgaaatcgag 2832601 ccctgtcggt gtgccgaaca aatcttcaaa gtgtgtcttc tcagaagcct gcggcaaaaa 2832661 ggagaaaatc cctcctccgt cattattgac aagaatcaca gtaagaggaa tacccagctt 2832721 tttggccgcc agcaggccgt ttaaatcatg ataaaaagat aaatctccaa tcacaagggt 2832781 aacaggcgct tttgttcctt cacatacccc catggcagag gagacgacac cgtctatccc 2832841 gtttgctccc cggtttgaat aaatccggaa agggcggtcc tgcttttcaa aaaacgtatc 2832901 aacatccctg atcggcatgc tgtttcccac aaacagcgag ctgttttcag gcacaagatg 2832961 ctgaaggatt cgatagagat tgccttcaaa cgaaacatct tcactgctga ttgtttgcag 2833021 atgctcgcgg aaccgcccat tgacaaactg ccacttttcc agccactctg aggatctggt 2833081 ggcagcagta aggcctgcca tgatctcctc agcaaaaaca gacgcattac aatgaatcat 2833141 atgcgcgctt gcctgtgtcg ggtctctcca ccctccatcc tcgtcaatca cgatttgctg 2833201 aatcgtcgga tcatccttaa gccataagaa aaccggtttt gaaacaggca tcggtccaaa 2833261 ccgaatgaca acatcaggac ggagtttccg cttcagctca tcatctttta aaaacgaatc 2833321 atacgcatca ataacagtgc ttttatcatg aacaccattc cgcagattag acagcggatc 2833381 tgctaaaatt ggatactgaa gcgcttttga cagcgcaata atgttttcct tgtccgcatc 2833441 actatggagc tctccgcaga cgatcattcc tttttcagcc tctgcgagca tctcagccac 2833501 atcagacagg gactctcggt caacagactg cgtacccgtt ttcacagaca catgacggcc 2833561 tgttctcatt cttccaaacg gctcatctga aagatccggc atcagcggtt cgcgcagcgg 2833621 cacattcaca tggacaggcc ccatcgggcg cttttgtgct tctccggcag cgcggcttgc 2833681 cagcgttcgg atgtatctca gcatttgcgg agactcttca ggaagagcag agtctgtgaa 2833741 aaacttaaca aagttaccga ataagaagtg ctgattaata gcctgcggtg cgcctacttc 2833801 gcgcagctca tgaggccgat cagcagttaa cacaataata ggcacccttg aataatgggc 2833861 ttcaaccaca gccggataaa agttggccgc ggctgttcca gatgtacaga tcaatagtac 2833921 gggacgctgc ttcgcttttg ccaaacctaa tgcaaaaaat ccggcagacc tttcatcaat 2833981 ttggacatgg acgctgatat cgggatgcgc agcacaaaga acagccagcg gtgtagatct 2834041 tgagcccgga caaacgacgg cgtccgtaat tccggaaagg gcgaattcat caataaaact 2834101 tccgatgtaa tgagtaatcg ggttgactgt caacgcctct cacctcctaa tgcagagatc 2834161 atcggcttca atttaatctg tgtttcttca tattccgaga ttggttccga gtcttccaca 2834221 ataccgcacc cggcaaacag ccttgctgtg cttccttcga tgagccctga acgaatggcg 2834281 accgcgaatt ccccgttatc ctggctgtca atccagccga taggggccgc ataccagccg 2834341 cgggacatcg gttcaatctc cctgatcacg tcaacagctt tttcctgagg tgatccccca 2834401 agcgcgggag tggggtgcag cttctcaatt aagtcaaaaa tcgaagcaga ctcgcgcagc 2834461 tgtccgacaa tcggcgtaaa caggtgctga acgctttttg ttttgtacaa aacaggtcca 2834521 tcaggctttt caacctctga acagcttgat acaaaagcat tatgaatcat acctaccaca 2834581 atatcatgct caagcaggtt tttctcatcg tttaataatt caaggcctat ccggcggtcg 2834641 tcttcttcat tcacgcctcg tttaatggag cctgccagac aggaagacat gacagtgccg 2834701 ccgtctcttt tgatcagtct ttccggagac gcgccgacaa aggttttgcc ttcttgttca 2834761 attgcaaaaa catagcttgt ctgctgatcg tccagaagcg ttttaagcac cggttcaatt 2834821 tggattggac cgtcaaacgt gagcagcagc tctcgggcaa gaacaacctt atcatattgt 2834881 ttctctttaa tttggcttgt ggccgtttcg attgctttca gccaatcatc cttatccagc 2834941 tcttcggctg ctgcaatcac agcctgatct tcttgcttga aatcgggaac cataaattcc 2835001 gccgcaaaag cttttaagcc ttctaaaaca gcttctgcgt cttctcctcc gcttacccat 2835061 ctgttaactg ttaagaacgg gccttcagca gtcatcgtca gcataagcgc aggcacaaag 2835121 aaatcccctt ccgagaaatg gtcccattgt gaacctcttt cttcgcaagg gtcaaaagaa 2835181 aatcctccga ataacacagg tcccactgca gaatgctgca gcttttcttc ttcataaata 2835241 tgaaaagccg tctttttaaa gcgctcccat tgttcaaaaa cctcacgata ccgctcgctg 2835301 tttttttgat ttgtctggaa aaccgcttct ttgccaagac cgactattgt caattcactt 2835361 tcaggatctg accaaaaaaa tcgattgcct gtatattttt ttgctccgta attgaaaaat 2835421 gatagagggt caagagactc gatttgtctc gaatagctta ttaagacagc atggttgact 2835481 tctttggctt tatgtaatgc atgtagaact tcctttcgga acgtacgctg caccgttgtc 2835541 accatgagac attcctccat aatccttaaa atgcttttaa taccatacac ctgtgtctcc 2835601 tttgtgtcaa acacagatca tgcagtccaa atggcctgcc ttacctatta taaacctaat 2835661 ttcagaaatg aaaaagaaac aaagcttaaa tttctttctc cactgatagc aaaggttgta 2835721 tccgcttacc ataaaaggaa aacctcctat attcctccac ccgccattta tgaaagttct 2835781 caggcgatct gttcatacta aaggtatgca tcacagagaa acgaggcgat cacattgctt 2835841 acgaaagaac agcttcagca tttaaaaaat gaactggaac aaacgaaaaa agatatctta 2835901 aaccgtttca aagacaatga tcattttcag cttaactcag cctttcctta tgattcgtgg 2835961 ggtgagcttt cggcatacga caaccatccc ggcgatcagg cgacagaact ttacgagcgt 2836021 gagaaagaca tcgctctaga cttgcatgag agagagcacc ttcgggacat tgagcattca 2836081 ttgaaggcga tagaaaacgg tacgtatggc atttgtgaag tcagcggaaa ggaaatccct 2836141 ttcgaacgac ttgaagcgct tccgactgcc acaaccctcg cggagtattc gtcacaggac 2836201 gtggtttcca aagaccgtcc gattgaagaa gaaacaccat tcgggcaatt tgaatttgat 2836261 gatgatgaag aaatcagagc gccatatgac agtgaggatt cctatcagga tgtcgaaaaa 2836321 tatgggaact cacaaacgcc gcaggatatg gaaaaccctc cgctcagcta tgatgatatg 2836381 acgatgaatg ccgaagagaa tatcggcaat acggagtctt acgaaaattt catcgctaca 2836441 gatatcactg ggaaagaaat taccgtttat caaagcagag cccatgagcg ctatgaagaa 2836501 gaacttgacg aagagggaat catgaccaca ttcggcgatc tccacgctga ttgaaccccc 2836561 aattattggg ggttcttttc cgttttcagc atatcgtaaa tcagcttcag ataatccttt 2836621 tgcaggccga tgtcataccg ctcgccctct agcaatttcc cgtatacggt acatgccccg 2836681 agcgaagctt ttatcgcatc cgttacctgc acttctcctc cgctatcagc ttctaatgcc 2836741 tccagctcat taaaaatatc cggtgtgaaa atataacgcc ctgctgcggc aaaatgagac 2836801 ggagggtttt gtttaggctt ttccacaata tcctgtatgc gataaagccc tttttcaaca 2836861 ggctcccctt ttatcacccc gtaatgatgt aaatcctccg tttttgtttc ttttaagccg 2836921 atcacactgg actgatattt cgtatacgct tcaatcagct gccccaaagc cggctgattg 2836981 gcggaaaaaa tcagatcatc tggcaaaacg acggcaaaag gctctcctcc tgcaaattgc 2837041 tttccgaaag aaatggcgtc gccaagaccc tttgcataag gctgccgcac atagtgaatc 2837101 cgtatatccg gaatgggatg ctctctaagt aaatgcagtt tattcttaga ggccaaaaaa 2837161 gcctcaagtg ccaaagagga atcaaaatag tcgacaatca gatttttatg gctcgataca 2837221 accatcaaaa tgtcctcaat gcctgactcc tttaattctt caacaagata atgaatcaca 2837281 ggcttagatc ctaccggaaa catttctttc ggaatcacct tcgtcaccgg cagatttctc 2837341 gtgccgaatc cgcctgcagg aatgatcgct ttttttatca tggtattttc ccctcagctc 2837401 atgtttatta catgatattc caagagcgca tcccgatgtt tgtacatctg aaattaggcg 2837461 gaagcaactg ggcagaaagc ggaatcacga accagccctt ttttaatagg atattgatat 2837521 atgaccagta atcttgtaaa ggagctcagg tgatgaaaat ttgtgtggtt ggcgccgggt 2837581 atgtcggttt aaccctatca gcggcactgg catccatcgg acatgacatg atatgcacag 2837641 acaaagacgt caaaaaaatc gggcagctga aaaaaggagt cattcccttt tacgagcctg 2837701 ggctttcaga tgcaatactt cgttgcggca atctctcgtt ttcttctgaa gtgaaatcga 2837761 gcatggagga atgtcccgtt atttttatcg cagtcggaac tccgccgcgt tcggacggat 2837821 cagctgatac gaaagccctg cagtccgtca tcggtgattt aagcgaggcg atccgatcgt 2837881 ataaaaccat tattacgaaa agcactgttc cgcccgggac aaatgaaaac atagcaaaac 2837941 agctgattgc ctccggagtg tctaaaaacc tctttaatat cgtatccaat ccggagtttc 2838001 tgcgggaagg caatgcctta tatgacatgc tgcatcctga caaaacagtc atcggtgttc 2838061 aggaagaaga tcacgtatcg gcagccatcg tcaaatccat ttacaaacac attgataccc 2838121 cttttatcgt tacaagctta gcgggagcag agctgatcaa atatgccaac aatttctttt 2838181 tagcggccaa aatttcgttc attaacgaaa tggcccgcat atgtgaagcc tatcaatcag 2838241 atatctcaga tatttcccgc gctatcggtc tagacccaag gatcgggaag cactttttgc 2838301 aggcaggcat cggatacgga ggctcttgtt ttccaaagga tctgcaggcg ctgcaatttg 2838361 ctgcccagga aaaaaacacg gagaccttcc tgctccgggc cgtgcagcac attaatgaca 2838421 cccagcttgg cctgtatatc aaaaaaatac agtcattctt cgaaacactt caaggcaaga 2838481 aagcggctgt actcggcatt tccttcaaac cgaatactga tgacatccgg aattctcagg 2838541 ctgtcagact gatggaaagg ctggcggagc tgggatgtga tgttcatgca tatgatcctg 2838601 aagctgtact tccagaacat ttgcggcaac atgtaactca gcattctcaa gcttttgatg 2838661 cgatcgaaga gagtgacttt ttatttttgg cgacagaatg gtctgagttt ttagcgtttg 2838721 attggaaaaa ggctgcagat atcatgaaag ggcgtcttgt gattgacgga cgcaacgtac 2838781 taaaaaaaga actgatcgag gcttgcggcc tgatctgtac gggagttggc cgtccatgaa 2838841 aatactcgtc acaggagcag cgggctttat cggctcccac ctctgcgaag aattactaaa 2838901 agataagaaa cataacgtta tcggaatcga tgactttatc ggtcctactc cattttcctt 2838961 gaaattaaaa aaccttaaaa acctgctgcc ggaaaagcga tttacgttca taaaggaaaa 2839021 tctgctgaca gccgatcttg cttccttact ggaaggagtg gacgtcatct ttcatttggc 2839081 ggccataccg ggtgtccgct caagctgggg caatcatttt cacccatatg ccgcacataa 2839141 tatccaagcg ctccaaaggc tcctcgaggc gtgccgggaa cattctattc aaacgttcgt 2839201 ctttgcatcc acctcttccg tctatggcga aaaacaagga aaagtcagcg aaaacacgtc 2839261 gctttctcct ttatctccgt acggggtaac aaagcttacg ggagaaaagc tttgccatgt 2839321 gtataaacag agctttggca ttccaattgt gattctccgt ttttttaccg tatacgggcc 2839381 aagacagcgg ccggatatgg cttttcaccg gctcattaag cagcaccttc agcaaaagcc 2839441 gcttaccatc ttcggtgatg ggcagcagtc aagagatttc acttatatca gcgactgtgt 2839501 caaaggcatc accgctgttc ttgggaaacc ccaccttatt ggtgaaacag taaatatcgg 2839561 cggcgcagag cgtgcctcag tcttaaaagt tgtctccctc attgaggata tttccgggag 2839621 aaaagcaaca ctgcactttt cggacaaaat agcaggggaa ccgagcaaca cgtgggcgga 2839681 tatttcaaaa gcaaaacagc tcttgcatta tgatcccgcc acatccttaa aggatggctt 2839741 gaccaacgaa atcgcctatt tatcgtcgct gtatcagggg gaataaaaat gaagcttgcc 2839801 tttatctgta cagaaaagct gccggcgccc gcagtacgcg gcggcgctat tcaaatgatg 2839861 attgacggtg tcacgcccta tttcagcagc aggtacgacc tgaccatttt ttcaatagaa 2839921 gatccatcgc tcccaaaaag agaaacaaaa gacggcgtac attatatcca tctgccaaaa 2839981 gaacattacc gcgaggcggt agccgaagag ctgcgagcct cttcctttga cctcattcat 2840041 gtgttcaaca ggcctttaaa tgtctcttta tataaaaaag cctcaccaaa cagcaagatc 2840101 gttctgagcc tgcataacga aatgttttct gaaaaaaaga tgaccttcgc gcaaggaaaa 2840161 gaagtactcg acaatgtctc catgatcaca acagtgagcg aatttattaa acaaaccgtc 2840221 attgaacgtt tccctgaagc cgaggacatc acaaaagttg tgtattccgg cgttgattta 2840281 aactcttatc cgcccgtctg gacgatgaaa ggctcggctg tcagaaaaac ataccggaaa 2840341 aaatacggta ttgaagataa aaaagttatt ttattcgccg gccgcttaag cccgacaaaa 2840401 gggcctcacc ttctcattca cagcatgaga cggattttgc agcagcaccc tgatgctgta 2840461 ctggtcatag caggcgggaa gtggttcagc gatgacagcg aaaaccaata tgtcacctat 2840521 ctgcgcacgc tggcgctgcc atacagagac cacataatct ttacaaaatt cattcccgca 2840581 gacgatatcc caaacctttt tctgatggca gatgtatttg tgtgcagctc tcagtggaac 2840641 gaacccctcg cccgtgtgaa ttatgaagca atggcggccg gcacgccctt aattaccaca 2840701 aaccggggcg gaaacggtga agtcgtaaaa cacgaagtca ccggccttgt catcgatagc 2840761 tacaacaaac cttcttcatt tgcaaaagca attgacagag cctttacaga tcaagaatta 2840821 atgaacaaaa tgacaaaaaa cgcccgaaag catgtagaag ctttatttac ctttacccat 2840881 gctgccaaaa ggctcaatac tgtttaccaa tccgttctga ccccgaaaaa caaacaattt 2840941 ccgccgcctt ttctgacgca aaattttgat ttatcatcta tcaatcagct ttttgtgaaa 2841001 gcaaaaacat aaaacctaca gctcgtgttg caaaacgggc tgttttttcg ctacagagaa 2841061 cttaaaaaaa ggcataaatg tgactttatg ccttgcgctt tacagtttga gaaaaccatg 2841121 gagctggttt agattcactt ggaagaatga tgatttccac tttagcttct tccgctaagt 2841181 ctggttcttc atcttcatcc tcttcttcat atgggggcgc tgagcgtttc gaatcacgct 2841241 cctcctcagg ctccagagtg gtttcgaatt ttgtttcttc ttcatcatcg acgattttgc 2841301 gatctgtttc cttttccttc gtttcttttt gatattcttt cggtgcattg atgtgaggga 2841361 gctctcgaat gctgcccaca tctaaatgct tctcctcttc ttccttctca gctgagattg 2841421 agtcatgagc ctgccatccc atcggtccag gcggtgtaaa tacgaattgg tcgagatcca 2841481 gtttagaaat agaggctttt tgtctcgatg acctcatgtc aattcgcctc ccgatacgct 2841541 tttatctttt tatacagttc cggcagttta tccaaaaacg aatctttaga ttcttcaaca 2841601 gaaatcatgt tttgcagcgc ccagttatac ttctcatctg accacgtttt cttttgcttc 2841661 aaataatatt tgtgcccgat tgcacagaac aaatgcggaa acgcgagatc aatccaaagt 2841721 acctcgtact gtttttctgt gagcggatac actgcgtcgt aggccgcaag cagtgcaacc 2841781 atgaaatcag tatcccatac agaaagctta accatcactt tattcagcag aatacgaagg 2841841 tctcttgacg gcaaatcgta ggtaatcgag tgaagctcct ttaaaaaagg ctccccttcg 2841901 atctcagtca aacgtgccaa tgtaaaatcc tgaaaacaga atccgccatg ctcgagtgtc 2841961 tcttttgtcc aggtttcgta ttctgagtca tcaagcgctc tgagagcttc ttttcctctt 2842021 gccagcattt tatcagcatg ttttaagaaa gtttgcgaaa atacgtcatc aggataggat 2842081 gctgcgatct gcatattccc ttcaagttcc tgcagcttcc aacggtacaa tttgtgccat 2842141 tttcccagcc tgcttctctt cttgctttca tctgtgcaaa catatccttt tgaggcatga 2842201 tgaaaatggc cggcaaatga catgactttt ttcatttgct ctgcatcata gtaaatcatt 2842261 tcttttcctg tcactttgtc atataaactg taagaaacct gatccgtgcc caagcagcta 2842321 ccgccatttt ttgtttgatg aatcggcgct atcggcagcc ctttctcttg taaatgggcg 2842381 tgtgcctgag tgataaaaag catccgctcc ggtttcattt gcgcttcttt tagcagcttt 2842441 gggccatgat cagtttcgac ttcccagatt ttgcgcccgc ttttgttcga tttcagcgcc 2842501 acatggtcga tatgaaacgg ataataactg agaatttcgg acacaatctg ttcttcatgc 2842561 tctttttggt acactctgtt caccccttct atctgttctt ttcatagacg ctgagcagat 2842621 tttcagccac cctctgccag ccaaaattgc tttctgcctc acggcggctg tatttcccaa 2842681 gccgttcccg cttttccgag ctgctcagca aatcattgat acgttcggca tattgtttag 2842741 gattttcaaa gtcatgaatg atgtagccgt ttttcccttc ctctatgacc tctggattgc 2842801 ctccccgatt gcttgtaata ataggaagtc ccgcagccat cgcttcataa tgcacccttg 2842861 ctaaaggctc ctgccattgc gaagagcata caaatacatc tgacatggta taaaggcgcg 2842921 gaatgtcctt tggcttcaca aattgaataa atgtgacatg atccttttgc atcgcaccaa 2842981 gggtatgaag atgtttgaca tagttattta attcattatc tccgaaccat tttgacccga 2843041 taaacaccat catgacatcg gggtgctcct caatgatgtc cggcaaagcc tgcaataata 2843101 tgtgcgggcc tttgactttg ctaagccggc cgacaaacaa gacgattttt ttgccgtgaa 2843161 gccccagctc gcttcgcatc tcttcgcgag ctcgctgccc ttcattcgtc cagcgagggt 2843221 ggtacgtttt taaatccaca ccagaataca ccgtttttgt ttttgatcgt gctgacggaa 2843281 aacggcttgt gatcgtctgt ccgatataat cgctgaccgt aacaatctgc gctacggagt 2843341 cgatgcaaat ctcgccttcc gcctggctga ttttatcgta agcgaacatt tcattgtgaa 2843401 cgcttaaaat aaaaacagca tccggcgcct gtttcttcaa tttcggaacc cagcttgggc 2843461 gattacaaac atgcacaaga tcaaaacggc tctttttcag ctctgctcca acggcttctt 2843521 cataacggtc ttcatccaaa tgcacataat ggacaccgtc taccttctct ctatcagcga 2843581 gattcggatc tttaatagaa aacacagtca cctcatgttt ttttgcaatt aaaggggcaa 2843641 ccgcttcgag gtagatttga atggcgcctc ctcgaaccga tgggacagga agcttctctg 2843701 tggcgatcag tgctattttc atacatagcc tccattcctg catgattttt aactagttag 2843761 aatcatgata cggctgaaca accaacttgt gcggaatggg actgccctaa aaacaaaacg 2843821 ggtaaacaac cagattcatc tattaaatat agtcaaataa ctcaatcatt ttttcctttt 2843881 gattcataag gtaggagtaa aacaggtaag gatgtgtcct ttaatggcag aaaaccatga 2843941 agtcattgag gaggggaatt catcagagct tcctttatca gcagaagatg caaaaaaatt 2844001 aacggagctg gctgaaaatg tgcttcaagg atgggatgtg caggctgaaa aaatagacgt 2844061 cattcaggga aaccagatgg cgcttgtctg gaaggtccac acagactccg gcgcggtttg 2844121 tctaaaacga atacacaggc cagaaaagaa agcgttgttt tccattttcg cgcaggacta 2844181 tttagcaaaa aaaggcatga atgttcctgg catactccca aacaaaaaag gcagcctata 2844241 ttctaagcac ggctcatttc tatttgtcgt atatgactgg atcgaaggaa gaccgtttga 2844301 gctgactgta aagcaggact tggagtttat catgaaaggc cttgctgatt ttcatacagc 2844361 ttccgtcgga tatcagccgc caaatggcgt tcccatattt accaaattag gtcgctggcc 2844421 gaatcactac acgaaacgat gcaaacagat ggaaacgtgg aagctgatgg cggaggcgga 2844481 aaaagaagat cctttctcac agctttatct tcaggagata gatggcttta ttgaagacgg 2844541 gctgcgcatc aaagaccggc ttttgcaatc gacctatgtt ccatggactg aacagctgaa 2844601 aaaaagccct aacctttgcc accaggatta cggaaccggg aatacactct taggagaaaa 2844661 tgaacagatt tgggtcatcg acttagatac cgtatcattt gatctgccta ttcgcgattt 2844721 gcgcaaaatg attattccgc ttttggatac gacgggtgtt tgggatgacg aaacatttaa 2844781 tgtcatgctg aacgcatacg aatccagagc cccattaact gaagaacaaa aacaagtcat 2844841 gtttattgat atgctgtttc cttacgagct ttacgatgtc attcgcgaaa aatacgtccg 2844901 caagtctgct ttaccgaagg aagaattaga atcagctttt gaatatgaac gcattaaagc 2844961 aaacgcattg cggcagctta tttaagacca tcatttcccc cgcatatcgg gggtttgata 2845021 tttataagat aaagggtaat taaatacatg cggaggttgc aaatatgaaa aagattgtcg 2845081 gcgctttagc cgtttttgtg attacatatg cgctgttttc agccgcaggc tacctgtttc 2845141 ctgtggacca agaatggtac aattcattga aaaaaccgga ctggacgcca agcggaactg 2845201 cgatcggcat catttgggcc atcctgtttg ccctgatctc cctttcagca gccattgtat 2845261 atgctgcgtt ttcatttaaa ggtgcgaaaa gcttttggtt tacacttttg ataaattacg 2845321 tgctcaatca agccttcagc tatttccagt ttacgcaaaa aaatctgctg gctgcatcgc 2845381 ttgactgcct gcttgtcgcc atcacagcaa tcgtattact gatcattgcc aaaaaataca 2845441 gcagagccgc aagctatctt cttttgcctt attttttatg gagtgcattt gcgacgttct 2845501 tatcctttac aatcaattca atgaatctgt gaacaaaaaa agccgcttat acagcggctt 2845561 tttcacatca tcggcttgat gccccaaatg tccttcgcat attcccggat cgtgcggtcg 2845621 ctggagaaat atccagaatg agcaatgttt acaatcgaat gctcagacca tttccttcgc 2845681 tctcgataat cagcttgaat tcgctcctgt gcatctgcat atgagctgaa atccttcagc 2845741 acaaaatact catcattatg cggaagcagc gagtcaaaga tcgattcaaa ttcatctgcc 2845801 tctccttcaa aaaaaccatt gatcaactga tccgctacct gcctgattct cctgtcatgc 2845861 tgataatatt ccctcgacct atagccgccg ttttcctgat acgatagaac ctcatccgcc 2845921 tttaagccga acgtgtaaat acagtcaggg cccacccgct caaggatctc gatatttgcg 2845981 ccgtcatgcg tgccgatcgt caaagccccg ttcatcataa acttcatatt ccctgtacca 2846041 gacgcttcct tgcttgcggt tgaaatttgc tcacttacgt ctgatgccgg aaaaattcgc 2846101 tcagccatag aaactctata attttctaaa aaaacaactt tgatcagctg tttgaccgcc 2846161 ggatcataat tgactttttc tgcgacagaa tggatcagct taatgatttt cttggcataa 2846221 taatagcttg gtgaagcctt tgccccgaaa ataaaggttt gcgggtagat tgaaaacccc 2846281 gaatcctcct tgaggcggtt atacaaatac ataatgtgaa gaacattcag cagctgccgt 2846341 ttatatgcat gaagccgttt cacctgtacg tcgaatatgc tctcagggtt cacaaccacc 2846401 ccggccgtgc aaaaaatcaa atcggcaagc tcttgttttt tcttgctttt gttgttttga 2846461 aactgttcaa taaatgcagg atcagtggcg tacggttcta aacggatcag tgattccggc 2846521 tgcttgaccc attcatcgcc gatcgcctct gtaatgatgg cagacaagcc tggattcgct 2846581 tttaacagcc agcgcctgtg ggcaattcca ttcgtcttat tgttaaaacg attcggaaac 2846641 agcaagtgaa agtcgcgcat ctccctttcc tttaatatat cggaatgtat ttttgcaacg 2846701 ccatttacac tgtagctgcc tactatggcc agatgagcca ttttgacaac accatgcgct 2846761 gtaatcgcca tgttctctat ccttttccag tctccaggat acttttccca aactgcacgg 2846821 caaaacctct cattgatctc ttcaataatc atgtacattc gcgggagcag cggcttaaac 2846881 aaatgaatcg gccatttctc gagcgcttct gacaatgttg tatgatttgt ataagaaatc 2846941 gtatgtacag tgatatgcca agcttcttcc cagctcatgt tctcttcatc gagcaaaatc 2847001 cgcattagct caggcaccgc aagcgcaggg tgagtgtcat taatatgaat gctcactttt 2847061 ttatgcaggc cggataaaga tttatgtgtt ttacggtaat tgttcacaat gctttttaag 2847121 cttgcgcata ctaaaaaata ctgctgcttc agccgtaaaa ttttcccctc atcatgggtg 2847181 tcatcgggat ataagaattc agaaaccgct tctgtttctc gcttataaga caaaatatta 2847241 ccgccgtgat aatgggcata gggctcggcg ttccaaagcc ttaacgtgtt gacagtgccc 2847301 gtttcatagc cgatgatcgg gatatcataa ggaacagcgg taacaattgt cgcttgttca 2847361 tggcgaaaat gcaggcgccc gcttttttct gtcatatgga cttcgcccca aaacggcacg 2847421 tccactgctt gatccgcatt ccttacttcc catacgttcc cgtttttcag ccattgctca 2847481 ggcagctcca cctgatgtcc gtctacaatt ttttgctcaa acaaaccatg cttataacgt 2847541 atgcccatgc cgtgcccagg caggttcaac gaagcaagcg aatctaaaaa gcaagcggcc 2847601 aagcgcccaa gtccgccatt gccgagacct gcatcgttct ctatctgaag gatctcctct 2847661 aaattgatgc cgatttcctt taaaccagct tctacaacat cacgaacacc aagattcatt 2847721 aagttttgct caaggagctg accgagcaga aattcgattg ataaataata tgtctgcttc 2847781 ccggaatttg atctgctttt ttcattcgtt tcgatccaat cagcgctgat atactctctg 2847841 accatattgc ccaacgtttt atattgatcc agcttggcag aatctttaaa gctttttccg 2847901 cacgtcattt ccagacgctt taaaaataag tctgcaaagc gttctttact cgagaacatc 2847961 ccgtccactc cttgtcacct gctcgaaaat acgctgatac tctttagccg acttccccca 2848021 gctgtaatct gcattcatag cggtcttcac gatgctcttc catacatcct gttggcaata 2848081 aaacgacagc gccctttcta tcgtaaattt cagatcatgc gcattaaagg cggaaaacgt 2848141 aaagccattg cccgttccct cttcctcctg ataggcacgg acagtgtcgt aaagaccgcc 2848201 cgtttccctg acaatcggaa tggcgccata ttgaagagca atgagctgcc ccaaaccgca 2848261 cggctcaaat ttcgacggca tcaaaaacat atcagagccc gcataaattt gatgggctag 2848321 cggctcatca aacccgatat aagcccggca cttctcatga aaagcaaatt ctgcataccg 2848381 gaaataatct tcaaattcac gttctcctgt gcctagcaca accagctgta tgtcttgctc 2848441 ctcaagaagt tcgtgcataa ttctgcggac aagatcaagc cccttttgtt tagtgagcct 2848501 tgtcaccata ctgatcagcg gaatatcgtt tttctctgga agccccatcc gctgctgaag 2848561 cttcgttttg ttttccagct tgcatgcaag atcccctgaa tcgtattgcg cctctatata 2848621 agggtcgctt ttcggctgat agaacgtatc atcaatgcca tttaatatgc cggttacatc 2848681 atcttcccta tattgcaaaa cctgttccaa ctgctcacca taatacggcg tcatgatttc 2848741 atttctgtaa gtggggctca cagttgtcac atgatcagcc gcaatgatgc ccgctttcat 2848801 aaaattaaca aatccgttgc attctaacct ttcataatga aaatgatcca tctcaagacc 2848861 cagcaagtca tgtgtgacat caggagggaa tatgccttga aactgcaggt tgtggatcgt 2848921 gagcacgctt ttcatccgtt cataaaaagg atgttttctg tactcctctt tcagcaaata 2848981 attgaccatc gctgtatgcc aatcgtgagt atgaacaata tcggcttgaa cattcacaac 2849041 tttggcagcc tccagcacag ctcttgaaaa aaaggcaaac cgctcaccgt catcataatg 2849101 cccgtacaac gaatccctgt tgaaatagta ctcattgtcg atgaagtaat aattcacatc 2849161 attctctgcc atatgttcaa ttccgcaata ttgctgccgc cagccgacag ctacggtaca 2849221 ctcagcctgt tttttcatac gctttttcca cggttcaggt atttggctgt acttcggcag 2849281 catcacagct acctcattgc ctaatcgcgc aagcgccttt ggcagagcac ctgctacatc 2849341 ggcaagacct cctgatttca caaatggggt gcattctgac acagcaaata atatcttcaa 2849401 gaattcatca gctctccttg caccaaacct tttcttaata caagcggctg ctcagctgtt 2849461 cctgcagctt ccgtcgcctt gccgatttta acatccttat ccgaaatgac ctgctcaaga 2849521 agacaatcct ctccaatctg cgttttttgc ataataatgc agtttttcag cttcgtaccc 2849581 tttccgacat ggaccgccct gaacaaaatg cagttttcaa cctctccttc aagcacacag 2849641 ccgtttgcca ccaaagaatt tttgacagtg ctgtgctttc cgtatttcgt aggcggctca 2849701 tccttcactt ttgtatagat cggctgctgc ggcaaaaaca cctgctgcca aaaacgaggc 2849761 tgaatgagct ccatactgtg ggtataatat ttttccaccg aatcaatgac agcggcataa 2849821 cctgaatatt cataagggca aatggtcagg gcggaagatt ccttttcaac agcctcctga 2849881 atggttttat agcctttttc gctatgtccg tagatcagat cctttaaaag cgttgttgac 2849941 atgatataga tttgcagcga ctggccgtcc tgaaatacct cggtgacgtc gcagccaacc 2850001 tcctgatggc gtttcagcac atattgaaat tgaatgttgc atacggtatg gctgttggag 2850061 attacagcat attgctgagt gcttctgtgg aagtaatcta gatggtccga aaactggcga 2850121 aaggaaccga attcatcgta ttcgtgatga agatggggag acgggaaaaa aaagaggccg 2850181 tcctttttcc ggtgcaaatc ccattcctta cccgccccaa ggtgatccat gagcgaacgg 2850241 taacgatact tcggaaaaat tgcaacactc ctaatatccg cattcaccat gttggaaagc 2850301 ataaaatcaa tcagtcggta cctgccggca aaagggatcg ccccgagcga ccgctgtgct 2850361 gttaaatcct gaagagaatg cttatatgtg gtttcatcta taacacctaa catttgatta 2850421 ttgaacactg actctgcccc ctcttcagta attaaatcaa ttctttttct acaaattcct 2850481 ctgaaacgag cagcacctct tcaatgtctt tttcggagcg aatcactgcg ccatccggca 2850541 gcaccatccc attaggaacg atggcatttt caatgactac atgctcccca atcgtcacat 2850601 ccggcattat gacggatgat gtaacagtcg tatgcttacc aacagtcaca ccttgaaaaa 2850661 gaacggagtg agacacattt ccatatacaa cacaaccttc gttcacaagc gaatcttgaa 2850721 cctgcgcatc agatgaaata aattgcggag gctgatttgg attgacggag taaattttcc 2850781 atttgcgttc aaacagcttc agctccgagt cctcttttaa caaatccata ttggcttccc 2850841 acaagctctg caccgttccg acatccttcc aatatccctt gaacggataa gcagaaagct 2850901 tctttttctc ttccaaaagc agtggaataa tgtctttgcc gaagtcgtgg ctagaataag 2850961 ggttttgatc gtccatctca agatactgtt tcaaaagcgg ccaattgaat atataaattc 2851021 ccattgaggc aagattgctc ttagggaatt tgggcttttc atcaaaatgt gtgatcgtcc 2851081 catctggatt ggccttcatg atgccgaacc ggcttgcttc ctcccagccc acttcgatga 2851141 cagagatggt cacatctgct ttcttttcaa tgtgataatc aagcattttg ccgtagtcca 2851201 ttttgtatat gtgatctcct gataaaatca gtacatactc aggatcatac tgattcaaat 2851261 aattgagatt ttcataaatg gagcttgccg tccctttata ccatttgact tctgatgact 2851321 cggcataagg gggtaaaacc gtcacgccgc cattatatct atccaggtcc catgcactgc 2851381 cgatcccaat ataggaattc agctcgagcg gctgatattg cgttaaaatc ccgactgtgt 2851441 ctatgcctga attagaacag ttgcttaggg taaaatcaat aatcctgtat tttcccccga 2851501 aagatacagc cggtttggcc atattttttg ttaatccgct gagacggctg cccttcccgc 2851561 cggcaaggag catggctaca cattgttttt tcatcttttt atctctcctc tttttttaac 2851621 cgcccgtaaa atcgagatgc cgtaaggggg gatggtcatc gtgatataac acggtttatg 2851681 atgaagtgct ccctttttag ccgataacgg ctttttgttg atttgccctg agcctccata 2851741 tgtttcactg tcactgttaa gcacttcaat gtattgagta aaaaaaggaa ctccaacatc 2851801 atattgatga tagaccacgg gtgtaaaatt acaaatgatg acaagcgcct caccgtgctt 2851861 ttggccataa cgaataaaag aaaagattga ttgttcgtca ttatggacat caatccattc 2851921 aaacgattgt gcacgatggt catgctcata aaggattttg cttttttggt aaaagcggag 2851981 aagatcttgc gtaaaaacgc tggctttctg atgcatgggg aaggagtcca aaaaccaatc 2852041 aagctgttct gtatctttcc attcatcaaa ttgagcaaac tctgatccca taaagatcaa 2852101 tttctttccg ggatgcactg tcatatagcc cagcaaaagc cgatactggg caaatttctg 2852161 ccagtagtcg ccaggcattt tattgagaag tgattttttt ccgtatacga cttcatcatg 2852221 agaaaacggc aatacaaaat gttcactaaa cgcatatagt aatgaaaaag agataagctg 2852281 atgacaatgc cgcctttctt cgggcggcgt ctccatgtat ttcagtacgt cattcatcca 2852341 tcccatattc catttataat gaaaaccaag ccccccttcc tcaacggcac ctgtcacttg 2852401 aggccattct gtagaatctt ctgcaatcat catcacatgg ggatatgcct ctctcatggt 2852461 ttgattgagt ttttttaaaa aatcaacagc atatggattc gtgtggcgtt catcctgatt 2852521 tggccaatac aagatattag ccactgcatc aaccctaaat ccatctatat gatagaattc 2852581 cgcccagtac aacgcattcg aaattaaaaa actatgaact tccggtttcc ccaggtcaaa 2852641 gtttgccgtg ccccataacc agttctcccg atcacgttct tctttgtatt cataaagcgg 2852701 ttctccatca aacatataaa ggccatgtgc atctttacaa aaatgtccgg ggacccaatc 2852761 caaaatgact ccgatatttt gttgatgaca ttcatccaca aacttcatca gatcatgcgg 2852821 cgggccaaac ctgcttgtcg ggctgtaata ccccgttcct tggtaccccc atgaacgatc 2852881 atatggatgc tcatacacgg gaagcagttc aatatgggta aacccatgct tcttgatata 2852941 agggataagc gtctgactta attctttata ggaataatgc ctgccatcag aatgcttctt 2853001 ccaagaccca agatgcagtt cataaatgaa aacaggtttt tcatacagcg tcttagcctt 2853061 ctgtttcttt tgccattttt gatcttgcca gctgtatcct tccaaatcgt aagtaagtga 2853121 cgctgtgttt ggtctgactt ctgaataaat agcgtatgga tctgccttca gcctgatctc 2853181 accgttattc gtcacaattt cgtatttata tcgttccttt tctcctatac ctggaataaa 2853241 taacgtccaa atgccattat cattcactct gtgcatcaca tgctcttctc cagaccagct 2853301 gttaaaatct ccagccactc gtacttccga cgcatgaggc gcccacacac agaattcata 2853361 tccgcttttg ccattcagct cgcggtaatg cgagccaaac agctgatagc ttttaaacag 2853421 actgccttcg tgaaaaagat aaacatcatg tgctgtcggg ctggcagcgg ccatgtaatc 2853481 atcctttctg acatcatagt tttcatttat agtatttatt cgaagaaata aaaaaaagcc 2853541 ctttcctgaa agcgcttata cttatagaca attaacttca ttttctgaag aaaaacgaaa 2853601 tatatggaga tttttgtagt ctgtttttaa aataaagaac aaaatctaag acatatcatg 2853661 atttataaaa acaaaaaaac cttgcaggat atgcaaggct tctggatgac ccgtacggga 2853721 ttcgaacccg tgttaccgcc gtgaaagggc ggtgtcttaa ccgcttgacc aacgggccga 2853781 taattatgat atctgtaatc atatggcgga gaaggaggga tttgaaccct cgcgccgctt 2853841 acacgaccta cacccttagc aggggcgcct cttcagccac ttgagtactt ctccatttgg 2853901 ctccacaggc aggattcgaa cctgcgaccg atcggttaac agccgatagc tctaccactg 2853961 agctactgtg gaacaaaagt catggtgggc ctgaatggac tcgaaccatc gacctcacgc 2854021 ttatcaggcg tgcgctctaa ccagctgagc tacaggccca tgacgatata gaaatggagc 2854081 gggtgatggg aatcgaaccc acgacatcag cttggaaggc tgaggtttta ccactaaact 2854141 acacccgcaa tttttatttg gggcgattga tgggaatcga acccacgaat gccagagcca 2854201 caatctggtg cgttaaccac ttcgccacaa ccgccaaagc atattgataa atggtggctc 2854261 gggacggaat cgaaccgccg acacacggat tttcagtccg ttgctctacc aactgagcta 2854321 ccgagcctaa gtatttaaat ggcggtccgg acgggactcg aacccgcgac ctcctgcgtg 2854381 acaggcaggc attctaacca actgaactac cggaccattt taaaatttgg ttgcgggggc 2854441 aggatttgaa cctgcgacct tcgggttatg agcccgacga gctaccgaac tgctccaccc 2854501 cgcgatgatt aggaatatgt atggcggagg aagagggatt cgaacccccg cgggctttga 2854561 cacccctgtc ggttttcaag accgatccct tcagccagac ttgggtattc ctccgtatag 2854621 tggtggacct tgtaggactc gaacctacga ccggacggtt atgagccgtc tgctctaacc 2854681 aactgagcta aaggtccatt ggtagcggcg gaggggatcg aacccccgac ctcacgggta 2854741 tgaaccgtac gctctagcca gctgagctac accgccaaat atttttgaaa tcaagtggag 2854801 cctagcggga tcgaaccgct gacctcctgc gtgcaaagca ggcgctctcc cagctgagct 2854861 aaggccccaa gaatggtcgg gaagacagga ttcgaacctg cgaccccatg gtcccaaacc 2854921 atgtgctcta ccaagctgag ctacttcccg atttcatata gatcatggcg cgcccgagag 2854981 gagtcgaacc cctaaccttt tgatccgtag tcaaacgctc tatccaattg agctacgggc 2855041 gcaaaactta atgccgaggg ccggacttga accggcacgg tagtcaccta ccgcaggatt 2855101 ttaagtcctg tgtgtctgcc aattccacca ccccggcgtg gatggtatag ttggagcgga 2855161 agacgggatt cgaacccgcg acccccacct tggcaaggtg gtgttctacc actgaactac 2855221 ttccgcagaa atggtgcgga tgaagggact tgaaccccca cgtctgtaaa gacactagag 2855281 cctgattcta gcgcgtctgc caattccgcc acatccgcaa catgtaaatg gtgagccatg 2855341 aaggactcga accttcgacc ctctgattaa aagtcagatg ctctaccaac tgagctaatg 2855401 gctcttctta caatagactt gaatattata tcatataaaa gtggtgccgg caagaggact 2855461 tgaaccccca acctactgat tacaagtcag ttgctctacc aattgagcta caccggcata 2855521 tatgtaaaac cgatatgtat aatgaaaaat ggtggaggat gacgggctcg aaccgccgac 2855581 cctctgcttg taaggcagat gctctcccag ctgagctaat cctccatact tgcactaacg 2855641 tgcaattgct tggcggcgtc ctactctcac agggggaaac ccccgactac catcggcgct 2855701 gaagagctta acttccgtgt tcggtatggg aacgggtgtg acctcttcgc tatcgccacc 2855761 aaacaaattg agagtgttct ctcaaaacta gataacaggt gtgacatcat tcaaaaatat 2855821 ggttaagtcc tcgatcgatt agtatctgtc agctccatgt gttgccacac ttccacctca 2855881 gacctatcaa cctgatcatc tttcagggat cttacttcct tgcggaatgg gaaatctcat 2855941 cttgaggggg gcttcatgct tagatgcttt cagcacttat cccgtccgca catagctacc 2856001 cagcgatgcc cttggcagaa caactggtac accagcggtg cgtccatccc ggtcctctcg 2856061 tactaaggac agctcctctc aaatttcctg cgcccgcgac ggatagggac cgaactgtct 2856121 cacgacgttc tgaacccagc tcgcgtaccg ctttaatggg cgaacagccc aacccttggg 2856181 accgactaca gccccaggat gcgatgagcc gacatcgagg tgccaaacct ccccgtcgat 2856241 gtggactctt gggggagata agcctgttat ccccggggta gcttttatcc gttgagcgat 2856301 ggcccttcca tgcggaacca ccggatcact aagcccgact ttcgtccctg ctcgacttgt 2856361 aggtctcgca gtcaagctcc cttgtgcctt tacactctgc gaatgatttc caaccattct 2856421 gagggaacct ttgggcgcct ccgttacctt ttaggaggcg accgccccag tcaaactgcc 2856481 cacctgacac tgtctccccg cccgataagg gcggcgggtt agaaggtcaa tacagccagg 2856541 gtagtatccc accgatgcct ccaccgaagc tggcgctccg gtttccaagg ctcctaccta 2856601 tcctgtacaa gctgtaccaa cattcaatat caggctgcag taaagctcca cggggtcttt 2856661 ccgtcctgtc gcgggtaacc tgcatcttca caggtactat aatttcaccg agtctctcgt 2856721 tgagacagtg cccagatcgt tgcgcctttc gtgcgggtcg gaacttaccc gacaaggaat 2856781 ttcgctacct taggaccgtt atagttacgg ccgccgttta ctggggcttc aattcgcacc 2856841 ttcgcttacg ctaagcgctc ctcttaacct tccagcaccg ggcaggcgtc agcccctata 2856901 cttcgcctta cggcttcgca gagacctgtg tttttgctaa acagtcgcct gggcctattc 2856961 actgcggctc tctcgggctt gcaccctaac agagcacccc ttctcccgaa gttacggggt 2857021 cattttgccg agttccttaa cgagagttct ctcgatcacc ttaggattct ctcctcgcct 2857081 acctgtgtcg gtttgcggta cgggcacctc tcacctcgct agaggctttt cttggcagtg 2857141 tggaatcagg aacttcgcta ctatatttcg ctcgccatca cagctcagcc ttatgggaaa 2857201 cggatttgcc tatttcccag cctaactgct tggacgcgga tatccaatac cgcgcttacc 2857261 ctatcctcct gcgtcccccc attgctcaaa tggtgaggag gtggtacagg aatatcaacc 2857321 tgttgtccat cgcctacgcc tttcggcctc ggcttaggtc ccgactaacc ctgagcggac 2857381 gagccttcct caggaaacct taggcattcg gtggagggga ttctcacccc tctttcgcta 2857441 ctcataccgg cattctcact tctaagcgct ccaccagtcc ttccggtctg gcttcacagc 2857501 ccttagaacg ctctcctacc actgttcgaa gaacagtccg cagcttcggt gatacgttta 2857561 gccccggtac attttcggcg cagagtcact cgaccagtga gctattacgc actctttaaa 2857621 tggtggctgc ttctaagcca acatcctggt tgtctaagca actccacatc cttttccact 2857681 taacgtatac tttgggacct tagctggcgg tctgggctgt ttccctttcg actacggatc 2857741 ttatcactcg cagtctgact cccaaggata agtcattggc attcggagtt tgactgaatt 2857801 cggtaacccg gtaggggccc ctagtccaat cagtgctcta cctccaagac tcttaccttg 2857861 aggctagccc taaagctatt tcggagagaa ccagctatct ccaggttcga ttggcatttc 2857921 acccctaccc acacctcatc cccgcacttt tcaacgtgcg tgggttcggg cctccattca 2857981 gtgttacctg aacttcaccc tggacatggg tagatcacct ggtttcgggt ctacgaccac 2858041 gtactcatgc gccctattca gactcgcttt cgctgcggct ccgcatcttc tgcttaacct 2858101 tgcacgggat cgtaactcgc cggttcattc tacaaaaggc acgccatcac ccgttaacgg 2858161 gctctgacta cttgtaggca cacggtttca ggatctcttt cactcccctt ccggggtgct 2858221 tttcaccttt ccctcacggt actggttcac tatcggtcac tagggagtat ttagccttgg 2858281 gagatggtcc tcccggattc cgacggaatt tcacgtgttc cgccgtactc aggatccact 2858341 caggagagaa cgaagttttg actacagggc tgttacctcc tatggcgggc ctttccagac 2858401 ctcttcatct acctcgttct tttgtaactc cgtacagagt gtcctacaac cccaagaggc 2858461 aagcctcttg gtttgggctg atcccgtttc gctcgccgct actcagggaa tcgcatttgc 2858521 tttctcttcc tccgggtact tagatgtttc agttccccgg gtctgccttc tcatatccta 2858581 tgaattcaga tatggatacc actccattac gagtggtggg tttccccatt cggaaatctc 2858641 cggatcaaag cttgcttaca gctccccgaa gcatatcggt gttcgtcccg tccttcatcg 2858701 gctcctagtg ccaaggcatc caccgtgcgc cctttctaac ttaaccgtta aaaagaatca 2858761 ctatgtgata tcttgtgtta ctaattgaat gtgatgtcta ctgttatcta gttttcaaag 2858821 aacacgtttc gaaggaatga tccttcaaaa ctaaacaaga cagggaacgt tctgtttata 2858881 agaccttggg tcttatattc cgtataatat ccttagaaag gaggtgatcc agccgcacct 2858941 tccgatacgg ctaccttgtt acgacttcac cccaatcatc tgtcccacct tcggcggctg 2859001 gctcctaaaa ggttacctca ccgacttcgg gtgttacaaa ctctcgtggt gtgacgggcg 2859061 gtgtgtacaa ggcccgggaa cgtattcacc gcggcatgct gatccgcgat tactagcgat 2859121 tccagcttca cgcagtcgag ttgcagactg cgatccgaac tgagaacaga tttgtgggat 2859181 tggcttaacc tcgcggtttc gctgcccttt gttctgtcca ttgtagcacg tgtgtagccc 2859241 aggtcataag gggcatgatg atttgacgtc atccccacct tcctccggtt tgtcaccggc 2859301 agtcacctta gagtgcccaa ctgaatgctg gcaactaaga tcaagggttg cgctcgttgc 2859361 gggacttaac ccaacatctc acgacacgag ctgacgacaa ccatgcacca cctgtcactc 2859421 tgcccccgaa ggggacgtcc tatctctagg attgtcagag gatgtcaaga cctggtaagg 2859481 ttcttcgcgt tgcttcgaat taaaccacat gctccaccgc ttgtgcgggc ccccgtcaat 2859541 tcctttgagt ttcagtcttg cgaccgtact ccccaggcgg agtgcttaat gcgttagctg 2859601 cagcactaag gggcggaaac cccctaacac ttagcactca tcgtttacgg cgtggactac 2859661 cagggtatct aatcctgttc gctccccacg ctttcgctcc tcagcgtcag ttacagacca 2859721 gagagtcgcc ttcgccactg gtgttcctcc acatctctac gcatttcacc gctacacgtg 2859781 gaattccact ctcctcttct gcactcaagt tccccagttt ccaatgaccc tccccggttg 2859841 agccgggggc tttcacatca gacttaagaa accgcctgcg agccctttac gcccaataat 2859901 tccggaaaac gcttgccacc tacgtattac cgcggctgct ggcacgtagt tagccgtggc 2859961 tttctggtta ggtaccgtca aggtaccgcc ctgttcgaac ggtacttgtt cttccctaac 2860021 aacagagctt tacgatccga aaaccttcat cactcacgcg gcgttgctcc gtcagacttt 2860081 cgtccattgc ggaagattcc ctactgctgc ctcccgtagg agtctgggcc gtgtctcagt 2860141 cccagtgtgg ccgatcaccc tctcaggtcg gctacgcatc gttgccttgg tgagccgtta 2860201 cctcaccaac tagctaatgc gccgcgggtc catctgtaag tggtagccga agccaccttt 2860261 tatgtttgaa tcatgcggtt caaacaacca tccggtatta gccccggttt cccggagtta 2860321 tcccagtctt acaggcaggt tacccacgtg ttactcaccc gtccgccgct aacatcaggg 2860381 agcaagctcc cacctgtccg ctcgacttgc atgtattagg cacgccgcca gcgttcgtcc 2860441 tgagccagga tcaaactctc cgataaatgg atcacaggtt aagttcaccg catcctgcgg 2860501 cgacacctgt gtgacctgcg tcgtgcaggc cctagtttga ctgactacgc acatcgcagt 2860561 gcgattttta aaaactgaat taacaggtac gttttgtctt gtttagtttt caaagatcat 2860621 ttcgttactt ctcaatgaag cagctttact aatataacat tcagcttctt ttttgtcaac 2860681 aacttttttc aagttgtttt gaagcatcta gtttgtgtcc gctgtgcatc agcgacgttt 2860741 aataatataa cacctgtatt tatttattgc aatagttttt taaaaaaaat ctataaaaca 2860801 aataaactat aatcctcgcc atgatttcta aagcgtgtgt atcatataag tttcttaaaa 2860861 gaacatatac atcagtcatg tgatcttgtt gtttttttcg ttttcttgta tagtagaaac 2860921 gaactaaata ctgatgacca caaggggagc attaaagctg agagtgagcg gtttcgttct 2860981 gaccctttga acctgttagt taacgctggc gtagggatgt ggcaaagtca aatgaattgc 2861041 agatcgtaaa gcagtgcgtg gaacttttct catccttccg cgtgctgctt ttttgttgtc 2861101 cttttggttg tctgtcaatg gaaggagata gatatgaatc aatctaagca actggttcgc 2861161 cttattgaaa ttgccattat gacagcggca gccgttattt tagacattgt ctcaggaatg 2861221 tttcttagca tgcctcaagg aggctcggtc tccatcatga tgattccgat ctttttaatt 2861281 tcgtttcgct ggggtgtcaa agcaggtctt actacaggtt tgttgacagg tctagtacaa 2861341 atagcaatcg gaaacttgtt tgctcaacat cctgtacagc tattgttaga ttacattgtc 2861401 gctttcgcag caatcggcat aagcggctgt ttcgcttctt ctgtccgtaa agccgctgta 2861461 tcaaaaacaa aagggaaatt gattgtttca gtggtcagcg cagtttttat cggcagtttg 2861521 ctgcgctatg ccgcgcatgt catttcagga gctgtgtttt tcggcagctt tgctccaaaa 2861581 ggaacaccgg tatggattta ttctttaact tataatgcga cttacatggt tccttcattc 2861641 attatttgtg caattgtcct atgtttatta tttatgacag caccccgtct gcttaaaagt 2861701 gacaaagcgt aaaagtaaca atcccccagc gaattccgct gggggatttt tcgttatctg 2861761 ttaagaagtg tttttaaagc tgaaagatcc ggccagccaa gacctacttc tttcagcctt 2861821 actccggcaa tttcaaagtt gtcctccgct actctttcag gtgaataggc ctgataaaat 2861881 ataatcgagg gattctgctc aataacccaa acaaacatac ttgaaaaacc atgttgaagc 2861941 aaaaactccg ctccttttgc taagagcgcc ctgcctgcac cttgccgctg gcgctcttcc 2862001 agaagataaa tagcgtataa ctcgccgtca tagccttctt gttcagagcg aataggtcca 2862061 aatgaagcaa agccgaatac tgaacccttt tcgtcctgag caacaaatac tccctttaac 2862121 gagcgacttt tccatttgtc ttcaaattcc ttatagttca ggctgtttaa ataatcaatc 2862181 gggataattt cgtggtatgt tgtcctccag ctgtctacat gcacttttgc aatgtccttt 2862241 atatcctcta acttcgcttc acgtacagtt accatacggt tctgcccttt ccttactctg 2862301 atttttggat cgttttggct tctttgattt catttgttaa ttcattaatg ctttgtttta 2862361 cgtttccttt tcctgaaaag ttctcaagca tttcttttac atcaattcct gaggatgctt 2862421 ttaaactttc ttgcagactt gacattaagt tcgtcgcata gctggttact ttgtttgctc 2862481 cgcttgattc accgcttcct cctgtatcga caacggtgat tttatcaata tttgaaagag 2862541 gtgccgctgc ttgtttcgcg tattccggaa gcattttgac aatcatatcg aaaatcgccg 2862601 cctgcccgta ctgttcaaag gcggccgcaa ttttctcttt tgcttccgct tctgcaagac 2862661 ctttcaggcg gataacctct gcttctgtct ctcctttcgc tttttccgct tctgcttttg 2862721 ctagcccgtc aattcttact ttttccgcct cagcctttgc cattgcttca atactgtact 2862781 tcttggcatc ggcttccgcg agctgtttgg ctttctcagc tgctgcggac tgctcaacag 2862841 aataacggtc tgcatcggct tttttcttta cctctgagtc gtattgacgt tcacggcgaa 2862901 gaatttcttt ttcttctagt tctatttgtt tttggcgttc gataatttta acctgcattt 2862961 cctgctctgt gacttgctgg cgcgctcggg cagtctctaa atcatatgct tggtcggcat 2863021 tcgcttttgc cgtatcttgt tctctgcgga attcagccat tttgagctga ttgatttttt 2863081 cagcttcagc gatttccgtc gcccgttcaa gttctgattt ttttgcgtct ttatcggctt 2863141 ctgcccgctt aattcgggtt tctttatcag cctctgctgt tgcgatatca gcatcgcgtt 2863201 ttacttgggc aattctcggt ttccctaatg attcaagata accgttttta tcacgaacat 2863261 ctttaatggt aaacgagacg attacaagtc ccattttcgc gagatcctgt gaagcgacac 2863321 gctgcacctc ttgagagaat ttttctctgt ttttatagat ttcttctact gtcattgagc 2863381 cgagaatgga acgaaggtgg ccttctaaaa cctcccgcgc ttcctgctca cggtcgtctt 2863441 ttgatttccc taaaaattgt tcggccgctg tagcgatttc tcctatagaa ccgccgattt 2863501 taataatcgc agttccatcg gccattactg gcactccttg ttctgtatag acttcaggtg 2863561 tcgaaacatc gagtttgctt gataataggc ttagcggctc tgcctgctgg aagacgggaa 2863621 ggacaaaggt tcctccgccg cggacgattt taatacggtt gccgccttca tcgacatgaa 2863681 catttttatt acccagatag ctccctgtta caattaacgc ttcatcaggc cctgctgtac 2863741 gatacttcgt aataaacaca gctattagtg caattaataa aaagaataca actccgatga 2863801 tcattataat cggcattgtc atatcaaatt cctcctttta tgttaaatgg gttcatgcgg 2863861 agtaaccgaa agaactccgt tgttaatatc tacgactaac accgttgtcc cgtaactgat 2863921 ctgctgatta tcaaaactga ccgctgactt tgaaatggtc ccgcctatcc cttctatgac 2863981 cacttcacca aacccgtcaa ccggcacagc tgtaatcact ttaccgagtc ttcctctgag 2864041 atcatcttct ctatatgcca atgattcttc tgcagatgat aatggcacca gtacaaagat 2864101 gtgaagcaat accaccagca tgatcgaaag gatgcaagat aaaagcgcaa tcagcaagct 2864161 tgacagaggc aatacaagtt cacctatata tccgcccgct gaaaaacatg taaaaaatga 2864221 gagcactaat gtcggattaa gaaacggaat gccttctgac agccctgaaa atacatctcc 2864281 gaaaaacagg aataacagcg taaggctgcc cgcaataata agcgtataaa gatacattgt 2864341 ttgtataggt actccaaata actccaactt cctcatcctt tcttcatcaa tgcattgatg 2864401 aacggctgcc gttaccattt atacgagaca cctcgggaaa agtttcaaaa ttttaagaca 2864461 aataacccat ttgaagtgct ttataaatga taattgctta tatatatggt aatgtcattt 2864521 taggaggaga tatgatgagt atctttaatg aagccagatt agaaacgtgg aacgaattga 2864581 aaggactttc tgacgaaaag ctgaatcaaa agccttctgc tgaagaatgg agcatacggg 2864641 aagttcttga ccatttgaaa aaaatcgata tgaccgcaca aaaaatgttg aaggaacgtg 2864701 taaaggacgc tccgattaaa gaaattgaag aaaaaccgct tgaagtagca caggacagaa 2864761 ataataaacg gaaagccccg agtcatcttg agcctgcgca tgattttatt tcaggcagcc 2864821 aaatgaaacg tgagcttgat gtggtaagag agcagctgac tgctgcgatt gcctctctga 2864881 aagaagaaga ttttgaaaga gtgcttccgc atcctgtgtt tcaagagctg actgtcagac 2864941 agtggatcga ttttatcggc catcatgaaa aacggcacct cagccaaatg aaagaaatta 2865001 aagaaaagat agaaagggcc tgatttaatc agaccctttc tgcttttcgt ttgacttttc 2865061 gctgatagga atgaacttct atttcatcac ctgtgtaaac agcaccaggt ctctccacaa 2865121 tacagacaat ccctctaatg cccagtgcgt ggcggacgaa agccgacgcc agcttcggtt 2865181 ggtccggata ataagactga atgacttctc ccggctggat acacggatca ttttcgccct 2865241 cacacagcag agccgctccg ctcggaaaaa taatccggct tccttctttt aatgaagtaa 2865301 gatctggcat accgctgact gccacattcg ccccgagcca ttccggcaaa attctcggca 2865361 ctcccatttt taaagcgatt tcgttgcatt cctctattga aacaattgaa atttgtctgc 2865421 ggttgaaaat ttcagtccct cttgaaaaca ttggttctct ggctcccgct tttttggtca 2865481 ggccaaaatg caagtcgccg gggatgccgc cataatcaaa atcaagcttg tccatttgct 2865541 ttgttacgaa gctttttgta tctgcgatat ataagccttc cgcttttgca gtcatacgct 2865601 tccacatcag ctggcacctt ccttcttatc taaaatttcc acctatgctt cattatccca 2865661 aaaaatcccg ctctgtaaag gagcgggatt ttgattatac cgttttaggc gtaaggttaa 2865721 agcagcgttt gtagatccag ttgtatgctt tttcatttaa atctctaggg tttccgaagg 2865781 tttgcggatc tttcattgct tctttagaca agcgttcgat catatcaggt gatactccct 2865841 gctcttctaa agtcggcact tctaaatctt cgaccagatc atacatccaa ttgacagatg 2865901 ctttcgcagc ttcttctgtt gtcatcttgc ttgtatcaat accgaacgct ttcgcaatac 2865961 gcgcaaactt ctcaggatag cccttccagt tgtattccat gacagggccc atcatcgccg 2866021 ctacacattg gccgtgagcg actgggataa taccgccaag cgtttggctc atcgcatgag 2866081 cagcgcccgc tgattcactt ccgtaagaaa gaccggcaag catcgcagcc tgcgccattc 2866141 cgtaccttgc ttccagatcc tctccatcag caaatgccct cttgatgtaa tgagcggcat 2866201 actcaatcgc cattaaggca accgcatccg tgattggctg tgcaaatttc attgtatagc 2866261 actcaatggc atgggcgagc gcatcaattc ccgtcatagc tgttacatgc ggaggcattg 2866321 aaacatgaag ctcaggatca atgattgtca agtgcgctgc aatcagcgga ccgcccgtgt 2866381 tgaatttgaa ttctctttct tcatctgtga taaccgccca ttgggttact tctgatccgg 2866441 ttccagctgt agtgggaatt gtcgtcagcg gaggaatgcg gttttccagc ggttttttcc 2866501 catctgccgc ttcataatca agcacgcttc cttcgtgagt cgcttctact ccgattgctt 2866561 ttgctgtatc catggagctt ccgcctccga ctgccaccaa accattacag ttctcttttt 2866621 tgtaaagctc agatccttca ttcaccagac ggacaggcgg gtttggctca actttattaa 2866681 agagtaccac ttcaatgcct gcttctttaa gtgattcgat tacgggatca gcaacaccgg 2866741 ctttataaat cccagggtct gtgacaagga gcgcttttga aacgcccagt gcagctactt 2866801 cctcacccgt atgcttgatg gctccgattc catgcttaat cacagtcgga atttcaaatg 2866861 tgtggaattt ctgcatgctt tctaccttca tatttaatgt catcatcaat ctccccctct 2866921 tatgaattaa accagttaac cgctgccggt tttgtattgc ggtatacatg tttgacttct 2866981 gtgtattctt caaggcctat ttttccaagc tcgcgtccga acccggattg cttatatccg 2867041 ccccatggcg cttgtgcaaa gtacggatga aaatcgttga tccaaacggt tcccattctc 2867101 aagcgggctg ctacccgttc gcacttttca atgtcttttg accataccgc tccagccaag 2867161 ccatagatgg tatcattcgc aagctcgatt acctcttctt cagagctgaa ggtttcgact 2867221 gtcaatacag gaccgaaaac ctcttcctga acgattctca tgtcagaatt acagtttgag 2867281 aaaatagtag gttcatagaa aaagccgttt tgaagctcag gatcttccgg gcgtttgcct 2867341 cctgtctcca gcttcgcgcc ttcctctatt ccgatctcta catatttttc tacctttgcc 2867401 ctgtgctccg ccgaaataag cggaccgctt tctgtctcag catgaaaacc gtttccgagt 2867461 tttatgcgtt ttgcccgttt gaccagctcc gccaaaaatt gatcatgaat ggcatcctca 2867521 acaagcaagc gggaacctgc agagcatact tggccggcgt ggaaaaatac agcgtttaag 2867581 gcctgatcaa ccgcaacttc taaatccgcg tccttgaaaa caatatttgg gtttttcccg 2867641 ccaagttcaa gggcgatttt tttgacgttt ccgcttgccg cccgcatgat ttttttgcct 2867701 gtttcaattc cgcccgtaaa tgaaatcaaa tcgacgtctt tgtttacggc aagctcgtcg 2867761 cccactgtgg ctcccggtcc aagaacaaga tttgcgacac cttttggaac accggcttct 2867821 tccatcagct taaagacttt gattgtcgtc agcggcgtaa tctcactcgg cttcatgacg 2867881 attgtgtttc ctgcggccag tgcaggggcg attttccagc tcgcttgaag gagcggataa 2867941 ttccatggag tgatctggcc gcaaaccccg attggctccc taataatttt gctttctgaa 2868001 tcaggaatcg gagatgaaat gatctctccg ccatctttgt ctgccaagcc ggcgtaatat 2868061 tgaaaaacat tggcgatatc gtccatatcg gccttgcttt cttcgagtgt ttttcctgta 2868121 tcaagagatt caagctcagc cagctcctca agatcgcgtc tgattaattc cgcaattttc 2868181 agaacaattt ttccgcgttc aagcccggat agcgatgacc attctccttt gtcaaatgct 2868241 ctacgtgcgg ctgcgattgc tttgatggcg tcctctcgcc ctccctcgct tacagttgca 2868301 atttcttctt gattaaatgg gttgataata ctgcggatct gttctttttc ggcactgatc 2868361 cattctccgt caatgaataa tgtttgactc atataagcct ccttgacgta aataaagttt 2868421 gttaaataaa aatttaatgt ttttaacaac cttaatctaa catatggttt ttaaactgtc 2868481 aaagtcccat tttgattttt ctttttgact tttcctcatg tttcgttaag ataaagaaca 2868541 taaagaaata acttaacgaa tttaattttc taaaggaaaa gagggtcagt atggatgaaa 2868601 atccagaatt tgcagctata gaacaggctc gggatcttgt tattgactcc attgctgaaa 2868661 cgatggatct ttacggaatt acccgcagtg tcgggatttt atatgggacg atgtatatga 2868721 gggatgagat gacgcttgac gaaatgcgtg aggagttgca aatgagcaaa ccaagcatga 2868781 gcactggcgt caaaaagctt caagacttaa atgtagtgaa aaaaacattt caccggggca 2868841 tccgcaagca tacatttgtg gctgagaagg atttctttaa atttttcaca aatttctttc 2868901 cacctaaatg ggagcgggag gttcaagtga atgtaacagc gatcgaggaa gctcaagctg 2868961 atttacaaaa ggttttatgc aaggaagatc tcgatgagga tatcaaaaat gaagcactgc 2869021 agttatatga tcagctggaa agctctaaag cttactatga ctggctgaaa cggcttgctg 2869081 aatcggtgca gaccggagaa atttttaaat ttataccggt cgaaacaaag taaagcagaa 2869141 aacgcctggg aaactaggcg tttttttgat gtaactacta caaatttgaa aaatacggga 2869201 aaaacacccc atttacttcc aaaatatttg atggtaattt tatgtaggta aaatttgtat 2869261 ttggcctttc agaggaggtg aaaagcgggc aggcctgttt aatttatcat tttttagggg 2869321 gaattttgtt atgaaacgca aattattatc ttctttggca attagtgcat taagtctcgg 2869381 gttactcgtt tctgcaccta cagcttcttt cgcggctgaa tctacatcaa ctaaagctca 2869441 tactgaatcc actatgagaa cacagtctac agcttcattg ttcgcaacaa tcactggcgc 2869501 cagcaaaacg gaatggtctt tctcagatat cgaattgact taccgtccaa acacgcttct 2869561 cagccttggc gttatggagt ttacattgcc aagcggattt actgcaaaca cgaaagacac 2869621 attgaacgga aatgccttgc gtacaacaca gatcctcaat aacgggaaaa cagtaagagt 2869681 tcctttggca cttgatttgt taggagctgg cgaattcaaa ttaaaactga ataacaaaac 2869741 acttcctgcc gctggtacat atactttccg tgcggagaat aaatcattaa gcatcggaaa 2869801 taaattttac gcagaagcca gcattgacgt ggctaagcgc agcactcctc cgactcagcc 2869861 ttgcggttgc aactaatgta aaagaccggt taacgccggt cttttttgcg ttttaccctc 2869921 ccctttttct ctaatccccg ttatcttttt tctggtttaa aatttaaatt gacaaacact 2869981 agaaacagga gtaaattctt gagtgttcaa tttcatacag tctcttttac cgcttaatca 2870041 aacacgaacg ggggaaccaa cgattggctg ttttattaac agccttgggg tgaatcttac 2870101 taagtaagag ggggtactct gaatccctaa tccgacagct aacctcgtag gcgtatacag 2870161 agaggaggtc tattatcggc cattctttgc aatggtcttt tttgtttcaa aaacgttaat 2870221 tcactaaggg agatatgaac attgggaaga attaaaaata agcaatttgc cgtgatcggg 2870281 ctgggccggt ttggcggcag catttgtaaa gaacttcata gaatggggca tgaggtcctt 2870341 gcggttgata tcaacgaaga aaaggtcaat gcatatgctt cttacgccac tcatgcggta 2870401 attgccaacg ccaccgaaga aaacgaattg ctttcattag gaatacgcaa ttttgaatat 2870461 gtgattgttg ccatcggagc aaatattcaa gcgagtacgc tgaccaccct attattaaag 2870521 gagcttgata ttccaaatat ttgggtgaag gctcaaaact attatcatca caaggtgctt 2870581 gaaaaaatag gcgctgaccg cattattcat cctgaaaaag atatgggggt taaaatcgca 2870641 caaagccttt cagacgaaaa tgttttgaat tacattgatc tatctgatga atacagtatt 2870701 gtcgagctgc tggctacgcg caagcttgat tcaaaatcga ttattgacct gaatgtaaga 2870761 gcaaagtacg gctgcacgat cctggccatt aaacatcatg gagatatctg tctttccccc 2870821 gcgcctgaag acatcattcg cgagcaagat tgcctggtga tcatgggcca caaaaaggat 2870881 attaaacgtt ttgaaaacga agggatgtag acaaaggtga cacttcaaaa ggataaagtg 2870941 atcaaatggg ttcggtttac accgcctcaa gtgcttgcca ttggtttttt ccttaccatt 2871001 atcatcgggg ctgtcctatt aatgcttccg atttccacta cgaagccatt gtcatggata 2871061 gatgcccttt ttactgcggc ttccgctaca actgttacag ggcttgctgt tgtcgatacc 2871121 ggcactcaat ttacggtatt cgggcaaaca gtaattatgg ggctgattca gattggcggg 2871181 cttggattta tgacatttgc ggtcttgatc gtcatgatat taggaaaaaa aatcggctta 2871241 aaagaacgaa tgctcgtcca ggaagcctta aaccagccga caatcggcgg tgtcattggc 2871301 cttgtcaaag tcctgtttct gttttcgatc agtattgaat tgatagcagc actcatttta 2871361 tccatccggc ttgtacctca atacggctgg tcatccggct tgtttgcaag tttgtttcac 2871421 gcaatatctg cttttaacaa tgccgggttt tcgttgtggc ctgataattt gatgagctac 2871481 gttggcgatc ctacagtgaa cctcgtgatt actttcttat ttattacagg agggatcgga 2871541 tttacggttc tgtttgatgt gatgaaaaat cggcgtttta aaactttttc tttacataca 2871601 aagctcatgc ttacaggaac gctgatgttg aatgcgatcg ctatgcttac ggtctttatt 2871661 ttagaataca gcaaccccgg cacgctcggc cacctgcata tagtggataa actgtgggcc 2871721 tcctattttc aggcagtgac gccgagaacc gcagggttca attctctaga ttttggaagc 2871781 atgagagaag gaacaattgt atttacttta ttattgatgt ttatcggagc aggaagcgca 2871841 tcaacggcga gcggcattaa gctgactacg ttcatcgtga ttttaacatc tgttattgct 2871901 tacttgagag gtaaaaaaga aacggttatt ttccgccgtt ccatcaaata tccgattatc 2871961 attaaagctt tagctgtgag cgtcaccagt ttgttcatcg tgtttttagg gattttcgcc 2872021 ctgacgatca cagaacaagc gccatttctt caaattgtgt ttgaaacctt ttccgcattc 2872081 ggaactgtcg gccttacgat ggggcttact cctgaactga caacagctgg caagtgtatc 2872141 atcattgtca tcatgtttat cggaagaatt ggtcctttaa cgttcgtgtt ttcattcgca 2872201 aaaacagagc aatcaaatat ccgttatcct gatggcgaag tgtttacagg gtgatatcaa 2872261 aaaaatccgg cgtgcagtcg ccggattttt tatgattcga tatgagattg attttgtctt 2872321 ttttcctgtt ccgcgatgat ttcgttatcc tccgcgttat cacgggtcac tttttgcgta 2872381 agaatcgcac caactgctac aagtatcata acagcgatgt aataaccttt ttcattgagt 2872441 tccagattat cagcattata gagtccgata ctaaacaaaa atactcccgc aaaaaaagta 2872501 aaataagcta gtactgtaaa ggcaaccgtg tttctgcgtc tatatttctg cacctttgtt 2872561 ccctcccgaa agcatagtta aaaagtgata acttccgtgg aatattatac ctcaaattcc 2872621 ccggaatgga acaaagaatt aaaaatacca gtaaaaaggg cttaggttgc ctcctttatt 2872681 tcaacagctg aatcatcaat ccagccgata agtttatcat tgatttggaa ttggtaccat 2872741 acagactggc ctttctgttt tttagacaca acctttatgt ctttgccgac gtaagattgg 2872801 gcagaggtaa gccttatgga ccgatcatca gtagaaggct tggaccatac gtcttgaacg 2872861 gcactgtctt taatagaggc gtttaaatcc acagatttga gggatggatt tacctcatcg 2872921 tactcatcta aatcgtattt ttccacaata gcgctgattt tgtcagcgta gtcagggtct 2872981 gtagcatatc ctgatgtttg cagggcggtt gccgcttcct tataattccc tgcctcaagc 2873041 accggtttat acttcttttt attccacgat gtgccacgga cgaacaattg ggcgtgatca 2873101 tccatagatt caaaaaacgt gctgtatttt cgaaacttcg cgcgaatggt ttttcttttc 2873161 cctttttcaa cttcgtccgt ttccatcgtg acatgatggc ctttataatt cccttttacg 2873221 ccaaaaaggt tgttggcctt agcagccagt tcactgttcc cccagtccga ttcgagaatg 2873281 gcctgagcaa ttgtgatgct ggggagaaca tggtattttt catacaaaat ttgggcatgt 2873341 ccggacagac tgtctataaa tacttgctgt tcatcgattt cttcagtttc tttggatatt 2873401 tcaatcggtt ttgataaagt tgtcgctaaa acaaacagag ctagcggaat cgatacaagg 2873461 aaaaatagtg aaatcaagag tttacgtttt ttaagttttt tacgggccat gaaaaccttc 2873521 cttcgaatta aaagattacg aatgtaaaag aatctacctt ttagaatttt acttgcactt 2873581 ctaatatttt tcaattcttt agggataaag ttgggaaaag attgcaaaat aaaaaccttt 2873641 tcgctcaatg aaaaggtttt taccatgttt ctatttttgt aaatttctga gtgcattccg 2873701 atattccgta tcatttatta ctttatatga tttgacagtt gccttcgaca aaccttgtgc 2873761 tgagacggcc ggtttttccg gagctgtttt cgctttatca tgtggtttat gtgccagctt 2873821 gtgccccatt ccagtggcat tcatacaaaa tgacaggcag acgagcagca cgctaaggat 2873881 aaaagaaatg aagaagagat catgataagc agtcatcata gaatcctgta ccgaaccgct 2873941 ttgtctggca gcatcttttt tcgtgaaaaa gccgatgaga atgggaactc ccatatagac 2874001 aaacaatctt aaaaactgaa cagctgtcat tctcttgacc aaatcaggca gcgggcctcc 2874061 catggcagct cccatcagcc ctgcggcgac tgtcaggcct gttcccgctg caagcatgat 2874121 aaacagtgcc gcgaacatat aaagagatga tcgatcctgt atatgcagcc attgaaaatt 2874181 cacaaaaacg agaatgagtc cgccgataat accgagcatc cctggtccga ctttatcgta 2874241 taacagagcg ctcaaaatgg ccgcgatcgc cactccgatt aaaagagtca agcttaaaag 2874301 aatgagatgc tcctgagaaa tatcatacat ttgacggagc aagccttgaa aagcagaaag 2874361 gctgacagct accgttatcg tccctgcagc tatgatcaat aagccgagca ccggttttgg 2874421 cagcagcatc agtttaatag atatgaaggg gtttttcact ttatattcca caatcaatag 2874481 accaatgagc aaacataacg tcaccccgaa accaatccat acataacccg atgacagccc 2874541 ccatttttgc agaaaaatga atgaaaccgc tgaggctgcg gcaaggaaga cagataaaag 2874601 aattcccgca cgatcaagcg gctgttcttg atccgccgct ccgtgatgct catcatgaag 2874661 aaagaaatag ctcaccgcga caccgatcag ggacaaggtg ccaaagatga aaaacagcca 2874721 tctccaatgc ccgcagcttg ttgcaatggt tcccaggatt gtaccgatga taacagaacc 2874781 atagaatccc ccgatcagca caagcagtgc atagttcctg cgttcaatcg ggaatgacag 2874841 tacaagcatt ggaatcataa tcatcagcat gacgcctgtt gccgcccctt gtaaaaagcg 2874901 ccctgccgcc atcaatgcaa tatcgcctga acatgcgatg agcagtgagc ctagtataaa 2874961 gacaggtaat gaagccagat agacgggacg agcaccgaat tttttcctca gcagcggtcc 2875021 tgccggaact aacaaggcaa aggccatatt gccgatcaat atcggattta ctgatgtaaa 2875081 gacacttgtt ccaaccgttt tctgaacaag gccttgaact gacgacaatg ccgtgttaga 2875141 catcaatccc ggcccgaccg ctaagacggc gagcaaagaa atcacccaat agtgttttgt 2875201 cttcatgttg tcatcccttc ctatatgaat acatgcgaaa cacatcattt tttgaaaaca 2875261 aaagaagcta atagattttg cataccatta gctttcattc taatattctc cctttcaggg 2875321 gaaatgatat tattttatta taattatgtg aatgaatgag catataatca aatattattt 2875381 caaatcgatt gtgttttgtc aatggagtaa atttcaagca caacatagaa agcttgaaag 2875441 cttttccccg atattgtgtc tagaactgca cttatgaatc cctgctcgtt ccctcaagcg 2875501 aattaaagca ggccgtttta atcctttcaa tccactattc caactaataa actcaaataa 2875561 gttggtgata agacaacatt ttacccccac atttttttgt gttcactggg cgtttgccgc 2875621 ctctaaattg tatatgggta aataccatga attaacctat gaaataccaa tgtaagggag 2875681 gcaaaaacga atggaactgt atgagtgtat ccaagacatt tttggcggct tgaaaaatcc 2875741 atcggttaaa gatttagcaa cgtctttaaa acaaattcca aacgcagcaa aattgagtca 2875801 accgtatatt aaggaaccag accagtacgc ttacggccga aatgccatct atcgaaataa 2875861 tgaattggaa attatcgtga ttaacattcc gccaaacaag gagacaacag tacacgatca 2875921 tggtcaatcc attggttgtg caatggtgtt agaaggaaag cttcttaatt ctatttatcg 2875981 ttcaaccggc gaacacgcag aactctccaa ttcatacttt gtccacgaag gagaatgcct 2876041 tatttcaacc aaaggtttaa ttcacaaaat gtccaatcca acatctgaac gaatggtgtc 2876101 tcttcatgtc tactcccctc ctttggaaga catgacggtc tttgaggaac aaaaggaggt 2876161 attggaaaat tcatgattga cagataaact gctcactttg acttcactca actggaggat 2876221 tcagagaatg aaaccttttc ctcaaaacaa aaaaaccctt atcgaataag ggtttaaagg 2876281 tatggagcca agggggctcg aacccctgac ctctacgctg ccagcgtagc gctctcccag 2876341 ctgagctatg gccccgtatg taacgtcatg tttattatag atgattttat tttgaaaaac 2876401 aagctgtttc ctcttgaatt gacagaaaaa ataaggctcg gaaaagagcc ttatttttcg 2876461 acttacatca tgatcaaaag taaaatcaca ccgagaataa ttcgatagat tgcaaatggg 2876521 acaagtttga ttttgttaat cagccttaag aagaaacgga cgacaaacag tgcgaccaca 2876581 aaggcacaga taaagccgac gatgaaaaac ggcatcagat ccgaacttaa gctgtcccaa 2876641 tgcttcacga ggcttagaaa gctggctccc atcatgatcg gcatcgccat aataaacgta 2876701 aagtcggctg cagctcggtg gtttaatccg agaataacac cgccggaaat ggttgaaccc 2876761 gaacgcgaga aaccaggcca aagggaaaga cattggaata agccgacggc tatcgcctgt 2876821 ttataggaaa tgcggtcgag tgtgtctgtc gctgttttcc gtttattgac ccagtcagca 2876881 aaaagcatga ggattgcccc ggcaattaaa ccgatggcca cagttttaac ggaaaataaa 2876941 tattcatcaa tgtaatcttc aaacaaaaag ccgagaacag ctgcaggcac gagtccgacg 2877001 gcaatttggg caatgcttaa tttatgtccc tgctcctggt cgcttgtaat attttttttc 2877061 aagcccagta aatttaaaat tcggtcttta aacacgatag ctactgctaa aatggagcct 2877121 agctgaataa ccaccttgaa tgagttagca gcttcttctg acatcagatt acttgatttt 2877181 agccagatgt cgtctactat gatcatatgt cctgtcgaag aaaccggcgc gtactctgtt 2877241 aatccttcta cgattcctaa aatggcggct acaaacaatt cccatagagt catgattttg 2877301 attctcccca ttagacattt atttttttac ataacgggag cttcccataa atggaaagcc 2877361 cgtcttatat aactataaac gaaaatcaca ctttatgccc cggcgtattt tcattttttt 2877421 cttcatcgta taaatgtgac tgcattttaa accagtcaaa taaatgtgtc gtaatgactt 2877481 tggcaaccgc atagccggga atcgcaagaa tgattccaac aacgccaaac agcttgccgg 2877541 ctgttaacag cagaaaaata atcgtaatcg gatggatgtg aaggtttttt cccataattt 2877601 gcggagagat cagcttccct tcaatcagct gaacaatcgt ccaaacgatc accagcttaa 2877661 gcagcatgag cggcgatgtc actatggcaa tgataatcgc aggcgtaatg gcaatcgttg 2877721 gccctaaata tggaacgatg cttgtgcaag ccgcaatgac tgcaagcaat gaagcataat 2877781 ccagcccgat aatcaaataa ccgataaaca gcaaaaaccc gatacagaag ctgacaatga 2877841 tctggcctct gatataagag cttaaccgat gattcatttc gcttaagact gtatatgtct 2877901 gttctttcaa tcgagtcggc acaaacttca gtatgtagac cggtaatttt cttccgtctt 2877961 ttagcaaata aaatagaata aacggaaccg tgacgatcga aatgataatc tcagtcagtg 2878021 cgccgataaa attcccaaca ccggtaaagg tgctgttcac gatcgtcgct gcctgatccg 2878081 aaacctttgt agcaagatca gatatattaa tgttcatcgt ttgctgggcc tgattgacga 2878141 agttgctgcc aatcagctgt ttcgtctgat tttctacgac gtccacatat ctcgggatat 2878201 tgtcaatcaa actcataatt tgttctttta agaagggaat gatcgacacg atcgtgatcg 2878261 tgatcagccc gataaccaat aggtatagca gcaatataga atagattctt cttattcttc 2878321 ttctctccag aaaatcgacg actgggttta acagataaaa aacaatgcct gtcaaaataa 2878381 tcggaagtga tatcgttttg agcagaacaa taatcggggt gaaaataaat gatgtttttg 2878441 taaatactag aatatttaaa ccaatcagca gcagcacaag caaaaataaa acaaacttat 2878501 tatccaagaa gaatcgcttg aatctgccgc tccatgtttg caacgtctcc actatcgttc 2878561 ctccgtcata catagtttaa ttaaattgta cactatcgtc cctataatga aaaataaaaa 2878621 ccgttaattg ctggaaaagc tttctcggtt ttaacattct atttatatct atcatgtgat 2878681 tttgttcttt ttaagctata atttagctat atcatgcaaa aggagcgata cgagtgatac 2878741 gttttgcaat aataggaacc aactggatta cagaccgctt tcttgagtca gcagcggata 2878801 tcgaagattt tcagctgact gctgtttatt caagatcggc tgaacgcgct ggcgagtttg 2878861 ctgctaaaca caacgctgcg catgccttct cagaccttca ggaaatggcg gcgagcgatt 2878921 gctttgatgc cgtatacata gcgagcccga acgctcttca caaggaacaa gccgttctct 2878981 ttatgaacca tggcaagcat gtgctttgtg agaagccgtt tgcttcgaat acaaaagaaa 2879041 cagaagagat gatctcagcg gctaaggcaa acggcgttgt tctcatggaa gcaatgaaga 2879101 ccactttcct gccgaatttc aaagaactga aaaaacacct gcataaaatc ggcactgtcc 2879161 gcagatttac cgcaagctac tgccagtatt cctcacgata tgacgcgttc agaagcggaa 2879221 ctgttttgaa tgcgtttcag cctgagcttt ccaatgggtc attaatggat attggcgtct 2879281 attgtattta tccggctgtt gtgttgtttg gcgcgccgaa ggatgtaaaa gcaaacggat 2879341 atgctttatc ctccggagtg gacggagaag gaactgtcat tctgtcttac gacgggttcg 2879401 aagctgttct gatgcattcc aaaatctcta cttcctatgc cccggctgaa atccagggtg 2879461 aagacgggac gattgtaatc gatacgattc accggcctga acgtgttgaa atccgctacc 2879521 gggacggccg ccttgaaaac atcgcgatcc ctgatcctaa accggcgatg ttctatgaag 2879581 cagaagaatt tgtcacgctt ataaaagaga ataagctgga atctgaagaa aatacatttg 2879641 aacggtcttt gaccaccgca aaaattatgg aagaagcaag aaagcaaatg gggattgtat 2879701 accctgctga tcaagcttaa aaaaatccgc ccgcgtgcaa atgccgcggc ggatttttta 2879761 ttagacaatc ggagaagatg ccttcctttt taaaagcacc tgttgctcat attctttgat 2879821 gtcataaagc catgcctctt ttaccggaac gcccatttgc tcacagtagg aatcccagat 2879881 ggctccgaaa ggatatgttt tgaattcctc catcagggcc agcctttctg tatagcggcc 2879941 ctcttcctgc aattgtttta aatatccgtt cgggagaagc agggcataca ataaagcttt 2880001 gatcatattt ctcgttccga tggtccaggc ggctacacgg ttaatgctgg catcgaaaaa 2880061 atccagaccg atggctacct tctcaagagc atgatttcgt acaatttcaa gagcgatttc 2880121 tctcaattca tcatccaaaa ccactacatg gtcgctatcc caacgaacag gccgcgatac 2880181 gtgcaaggca agcttgtctg tgtaaagcag catggacgag atcttgtttg ataccgtctc 2880241 agtcggatgg aaatggcctg tatcaagtaa acaaagctta tgattcgtca aagcataagc 2880301 taaataaaat tcatgagatc cgacaacata tgattcggag ccaagcccga acagcttgct 2880361 ctcgattgaa tcaagattat gttgttcact gatctcctct gagaagatcc gatccagtga 2880421 ttcttttagt cttttacgcg gtgtcagcct atcactcggg atatccttat agccgtcggg 2880481 aatccaaata ttcgtcaagc aaggtgttcc taattctttc ccgaagtatt ccccgatacg 2880541 gcggcaagcg atgcaatgcc tgatccaaaa ttctctgatg tccggatcag ggtgtgaaag 2880601 ggtgagtccg tcagccgctt tctcatgcga aaacaaggtt ggattaaaat ctaaaccgag 2880661 accaaggttt tttgcccatt tcacccagtt ttcaaaatgc tgcggcttca attcgtcacg 2880721 ttctaccgct tccctgtttg tttctgcgta tatcgcatgc aggtttacgc ggtgctttcc 2880781 aggaatgaga gaaagagcct tctccaaatc tcttcttaat tcttcaggag tttgcgcttt 2880841 tccgggataa ttgccggtca cgtcaattcc gcctgaaagc tcgcccttat ttacttcaaa 2880901 gccttcaatg tcgtcaccct gccagcagtg gatcgaaatg ggcacttgct ctaattgccg 2880961 aagcgcctct tcaacatcaa ttccccattt ttcatatgcc tgttttgcac tgtcataatt 2881021 ggcttttatg gtcatacggc tctctccctt tatcagtttt tcaatccaaa taaaaaactt 2881081 cctttagatc tatcgcaaca ggactgaaat ccgaatttgt tttcattaat ggcgccatcg 2881141 atttccacca tctttggcaa acttccgtgt ccgccatctt tctccatttc tcttcatcct 2881201 ctatttctaa atatgcaaaa agcctgcctg tttcctcgtc tagaaaaatg gaataatggt 2881261 gtgctccatg agctttgagt gcttctgcca tctcaggcca aatgtcatca tgccgctgtt 2881321 tgtattcttc gtacttgtct tgatggacaa acatgatact ggcttttctt ttcaaacctt 2881381 ttcacctctt catcatttag atagcgcttt caaaacagtt tgctgaaatg actgaatgat 2881441 cgtgcttcta tcaatgtctt taggtgtaaa cactttgatc ggaaaggaat ttctgacgac 2881501 ttgccgggct tcttttatgt ctttgacttc tttggcagca atcatttgca tcaaaagatt 2881561 tccggtggca gttgcctcta tcggccctgc atataccgct tttccactca tgtctgccgt 2881621 taattgattt aagaaatcat tccgggctcc gccgccgatg atatgaaatt gctcgatcgg 2881681 tttttctgtg attgtttcga gctctttgat ggctatcgca tagatgatgg ctaaattgct 2881741 gtagatgcag caggcaagtt cgcctgcagt acggggaatc ttttggcggg tttgtctgca 2881801 ataatgttgt atttccttta tcatgttttc tggattcagg aaacgtttat catttaagtt 2881861 tataaattgc tggaatggtt ctgttttttt ggcttcttct gcaagctgct gaaaagaata 2881921 atctgcttgt agctgctgtt tgacttcttg tatcacccac atgccgataa tgtttttgag 2881981 aaagcgaatg gtgttgtttg cgccgcgttc atttgtatag ttgttttcta aagcaagatc 2882041 agttattatc ggtgttttgt tttcaacccc gattaacgac catgttccgc tgctgatata 2882101 cgcccagcca tcatttacgc ctggcgccgc aatgacggcc gaggccgtat catgtgttgc 2882161 gactgtcatc accttgcacg ccgggagatc ataatccggg aaccactcat ttcttagctt 2882221 cccgagttca caccccggtt cagtgagcgg cgcaaattgc tgttccagaa cagacacggc 2882281 ttcaagcaat tcaggatcaa gatttcccgt tgagacgttt aaaagctgtg ttgtggacac 2882341 gtttgtgatt tccgttacag cttttccggt taaacaatag cctaaataat caggaatcat 2882401 cataattttg tctgtctttt tcagcagctc acggtcttct tcaaacaatt gatagatcgt 2882461 gttgaaaggc tgaaattgta ttcctgtttt ttgataaatt gcggcttttg agagggtatg 2882521 ttccagtttg tctattgtgt gatctgttct tctatcacgg taggagattg cttcccgcaa 2882581 ccgatcgcct ttttcgtcca gtaagacata atcgactgcc catgtatcaa tgcctacggt 2882641 gcagtgttca tacccaagcg tctttacttt ttgcagtcct tgcaggattt gttttagcaa 2882701 atgatcaata tcccataagc aatgcccgtc tctttgactg aaaccgttag cgaacctgtg 2882761 aatctcttgt atgtcaagct tcccttcatt cagttcacct accatgattc tcccgcttga 2882821 tgcgcctaca tcaatggcag tataaatcat cctttcaccc tctcttcgaa agaggaacag 2882881 ctgtcacctt cacctttttg tcctcaagag cttttaccga tgccggatca agtccagaat 2882941 ccgtaataag gcggctgaca tcttgcagcg aggcgatatg tgaaaactcg cggttccccc 2883001 atttgcttga atcggccatc aaaatggtct ggtccgacct ttcgatcatc cgttttttga 2883061 gcagcgcctg ccactcattt gaatcactca tcccgttgtg tacgtcaaat cccttacatg 2883121 acagaaaggt tttattgaca tgataggtct caagtgaacg ctctgctaac gggccggcaa 2883181 atgataatga tttttccagc aaaatgccgc ctgttgaaat gactgatatg ttttctttat 2883241 tgctgagttc aatagctgct ttcattgagt ttgtaatcac ggtgagctca atgtcaggga 2883301 gtatttttgc catgtaccaa gcggttgtgc ttgcatcgag aatgattcgg tctccgcttt 2883361 ttacatattt ggccgcttcg tgagcgatgg cttttttttc gatgacattc gtgatttccc 2883421 gttcagaaaa atgaatttct gattccttct gctgaatact gaccgctcct ccgtggctcc 2883481 ggctcagttt atgttctttt tcaagctttt caagatcacg ccgaatggtt tcctctgtga 2883541 ctgaaaaaat gtcacttaat tcggaaacgc ggatgcttga acgcatattt actatttcca 2883601 ctattttttg ctgccgttct gctactagca tcggtaacgc ccttcctcat atcgtagtcc 2883661 gtcttatatt tttatcatag catatatcta acgcgtaaaa gcagcaggga cgccgccgtc 2883721 taccgtgatc atgcagcccg ttgttttttc ggctttggaa gaagcgaaga atgcaatggc 2883781 ttcggcaata tcctccgggt aaatattgac gagcaatgct gtccgtttcc ggtaatgttc 2883841 ctccagctga tccggttcaa tcccgtacgc cgcggctcgt tcctcacgcc agcttgaacc 2883901 ccagattgcc gatccttgaa gaactgcatc aggcaaaacg gagttgaccc taatgccgaa 2883961 ttctccgcct tctgctgcga tgcatcttgc taaatgggtt tcaagcgcct taacagagct 2884021 gtaggcagag gcgttttttc ccgcataaac tgaatttttc gatccgacaa ataccatgct 2884081 tccgcctcta ttttgatgtt tcatctgttt aaacgcttca cgggctacaa ggaaatagcc 2884141 tgttcctaaa acattcatat taagattcca ttcttttaga cttgtttcgt caaatgggct 2884201 tgatgtggcc agcccggcat tattgacgac gatatcaatg ccgccgtaag caagcgccgc 2884261 tcgttcaaaa gctgactgta cgtcttcctc ctttgtcaca tccattttga cagccattgc 2884321 ccgtcctttt ccgtatgcat cgtttatttc cccggcaatt ttctgtgcgc cttctatatt 2884381 cagatcagct acgatcacgt gccctccctc agctgcaaat cggcggcatg ccgcactgcc 2884441 gattccgccg gctcctccag ttatcagcgc tacttttcgg gaaaattctg cttccggcgg 2884501 ggccagcgtg agtttatata gttcgagcgg ccaatattcg acatggtagg actcattttc 2884561 atgtaaagaa acaaattgcc ccagagcggt tgctcctttc attacggcga tggccctccg 2884621 atataaagcc ccgcttactt tagacatcgc ataacttttt cctgtattca ccattccgat 2884681 tccaggaatc aatatcaccc gcggggcgga ttcaaagatt tgatccccat cctgctgatt 2884741 gcgtgtaaag taagcctgat actctgatgt aaaggtctcg actcctgact tgatcagatc 2884801 tgcaagcttg tgcacatctt gagtttccgg attccaatca atgtacagcg gaacccgttt 2884861 tgtgtgaaca aggtgatccg ggcatgccgc accgatttgc gaaagtgctg gcgcttggac 2884921 actgtttaca aattccaaga catcgtcatg atcatcatag gaaaggatca ttttcttttc 2884981 ttcacttact gctcctctga tcacaggcat gatgcctgcc aagatttgtt ttcttttatc 2885041 ctccggcagc ggctgatacc ttttgcctcc gaatacctca tgctgattga tacgatcgtt 2885101 aatatactgc tcggcttctt gaatgatgga tatcgttttt tgataacatg tttcagacgt 2885161 ctctccccaa gtgactaagc cgtgtttctc cattaataca agctcggcgt gggggttgtt 2885221 tgctacgcct tcagcgatca ttttagacaa agtaaatcca ggacggacgt atggcaccca 2885281 tacaaaccga tttccgtaaa tgtcttcagc gatttgtttt ccattatccg cacagcatat 2885341 gctgataatc gcatctggat gggtatggtc aacatgtttg tatggcagaa aagcgtgtaa 2885401 tagcgtttca attgaagggc ggggatgttt gctgtctatc atacaatgag acaggtagtc 2885461 taccatttct tcatcgggca tttggtccct tttaatcagc gggcggatat catctaattt 2885521 caaaccggaa aagttatgcg ctttcattgt tgccaaatcc gatccgcttc cttttaccca 2885581 catgacttct atttcacggc ctctaaaatc cttttccgtt gttttcatag atgtattccc 2885641 cccgccccag ttgcagacag tgcggtctga cccgatcaga ttggacctgt acaccaattc 2885701 ctctacacct ttaggtagct gtgcagctcg ctctgaatcc catatatgtt tcaccatatt 2885761 tgatattcct ccataccctt ttatttgtat ccgttttcat tatatatgat ttctgtttgt 2885821 ttttgaatcg tttttgttta tttttgcttt ttaacaaaaa aagaaagcag cagatatgcc 2885881 gctttctcgt ttcattatga ttctatttta aatttcttcg taatgtcctg aagttcttcc 2885941 gccatgtttg ccaacgtttc cgctgaagag ctgatttctt ccatggacgc aagctgttct 2886001 tccgccgaag ctgcgatatc ctgaatgcct gctgagcttt ctttcgccac tgcagaaata 2886061 tcttcaacag cacttgacac ttcctgtgat ccggctgaca gttgttcaac cgtcgcgttc 2886121 aagttttgca attcgccgga aatttgggtt gtcatctcat agatttgttt aaagctttcc 2886181 gctgtttgat ccgtaatctg caagccttct ttcacttcat gattcacgga ttggaacatt 2886241 gaaagtgagg tgctgatttc cctgacaatc tcttgaatta atccttcaat ttccttggcg 2886301 gagtctgctg attgtacagc aagttttcta acctcttccg caactactga gaaacctctt 2886361 ccgtattctc ccgctcttgc cgcctcaatc gcagcattta atgcaagcag gttggtttga 2886421 tcagcaatgc cgttaatcac attcaagatg cttgtgatgt cttgcgattt tgtttcaagg 2886481 cccttcacaa ccgcttccgc tttttgaacg gattggtcaa ttgttttcat ctggccgact 2886541 gtatgctcca ccagcttttc tccgctgccc gctgcctcag aggactgaat cgatgatttc 2886601 gtaatggttg aagaggcttg agccactttt gaaatcccct cgttcatttg agaaagatga 2886661 tttgagcttg tttccagttt ctcgctttgt gcctcgttgc catctgagaa ctgttcgatg 2886721 gcaagtgtaa tatgttcagt tgccttgctt gtttgggctg cgcttgctgt cagctcctca 2886781 gaagatgaag cgacgttttc tacagacgtt tgaataacgc ctattacaga acgcaatgat 2886841 gcagacattt cattaaagct ttcgccaagc tggccaaact cgtttttcga gtgaatgtca 2886901 atgacttctg tgagatctcc gctgctgatt tttgcagacg ttgagacaag ttttcttaac 2886961 ggcttggtga tggcacggat aatatagagt atgagtatgc cgccgattac tattgacacg 2887021 catagaatga taaccgcagt gttcagcacc gggcttgaag catcttgcaa ttcactgaca 2887081 aaatatgtgc ccgcgatttt ccagccagtc agtttatttg tcgtaaaggc cattttcttt 2887141 tctttgcctt cgaatgtata ttcaaatgag ccttcttttt tggaatatac ttggtttgtc 2887201 caatcgccgg aaccggttgt ccccggctta atggtcggat gggcgatata ttttttgttg 2887261 cctgtcgtaa taaatgcaaa gccttctttt ccgattttga ttctttttga tgcagtaagc 2887321 acttcatcca ggtttaaatc tagcgctata acccctgaac cgtcttttaa ttgttttgaa 2887381 attgtgacaa cgatatctcc tgtcgcttca tcggtatacg gttctgagaa aacagcttgt 2887441 cctttttccg caaccgcctg tttgtaccag tcacgtcctg tcggatcgaa acctttcgga 2887501 acaccgctat ccggatattt ataaagcttc ttatcttctg aggcagcata gattgcgcct 2887561 acatcgtcgt taagtgtcgt gtactgctta aatttctctt tcagtaatgt tttgtttttg 2887621 cctaacaata tgtctttatc gactgtctca ctataataat ctattgcttt tactttatct 2887681 tctaatttat tttgcagcgt actgtttagt tcttcaacat ttcccttcgc actgcttatg 2887741 agctctctgt ctaacgcgtt ccaagctgat tgataactga aatatgctaa aaccccaacc 2887801 ggcaaaataa gcactgccag aaacgcagcg attagcggtt tgctgatcga tggctgtttg 2887861 atccattgta tgaattttcc cattctcgtt gactcctcct ttaagataaa tctaatatcg 2887921 tcaaactagg ataaaaggtt taataaaaaa actaaaaaaa acacccaagc gcaacaagct 2887981 tgggtgttaa ggcttattat tcaattttaa atcgtttggt catatcccga agctcttccg 2888041 ccatagagga aagggtctct gcagacgagc tgatttcttc catggaagct agctgctctt 2888101 cagctgacgc cgcgatatct tgtatatgcg ctgagctttc ttttgaaatc gatgcaatgt 2888161 gctcagacgc tcccgaaact tcttcggagc tggcagaaag ctgctgaacc gtcgcactca 2888221 tattttgcag ttcgccggcg atttggttcg tcatttcaga aatgcgtttg aagctcattt 2888281 ctgttttatc tgtgatgtca agtcctgtct gcacctcttg attgacagat tggaacatgc 2888341 cgagtgatgt attgatttcc ttcacaattt cgatgattaa tccttcaatc tcttttgctg 2888401 aatctgctga ctgtactgcc agttttctta cttcttccgc tacaacggag aagccgcggc 2888461 cgtactcgcc tgcgcgcgct gcttcaattg ctgcgtttaa ggcaagcagg ttcgtctggt 2888521 ctgcgatgcc gttgatcaca cgcaaaatgt ttgtaatatc tttcgatttc gtttccaatc 2888581 cgcgtacgac ttgctccgct tctttaacgg acttgtcaat gacattcatt tggccgacgg 2888641 tttgatgaac aagcttgccg ccttcacttg caatttctgt cgattgaaca gatgaatcag 2888701 tgatcacttc agaagcttga gccatattcg tcaacccgtc attcatttga taaatgtgct 2888761 ctgctgccgt ttcaatgttt tcgttttgtt tttcattgcc gttagaaaat tgttcaatcg 2888821 ccaatgtaat gtgctctgtt gccttgctcg tttgcgcagc tgatgcagtc agctcctcag 2888881 aggaagcggc aacattgtct accgaatcct ggatggcgtg tatgagagaa cgaagtgacg 2888941 acgccatatt gttaaagctt ttgccgagct cgcccaattc atcttttgaa cggatatcaa 2889001 tggtttccgt caaatctccc tcgctgatcc gcttagagga accgacaagc tgtttcagcg 2889061 gtgttgtaat cgaccgaatg atcaatgtca tgacgataat ccctatgata atagctgcgg 2889121 ccaagacaat taaagcaagg tgaaggacag gctgggctgc ctcatggatt tcatccaaat 2889181 acatggtgcc gccgatcttc catcccgtca acttgtttgt gtcaaaggcc atttttttct 2889241 tatcgccatc catggtgtat tgaaaatcgc ctttatcagc actcaacatc ttatcgagcc 2889301 agtcgccttt taattcagtt cctgattgtt cattagggtg tgcgacaact tttttgtcct 2889361 tcgtcatgat aaatgcgtag ccttgtgtgc cgatgttgac ttttttggtt gttttcagca 2889421 gattttcaat cgtcatgttg attgcgataa cgcctgaacc atcttttgtc tgctgggcga 2889481 ttgtcacaac catcgtattt gtcgacgcgg ttttataagg gtctgtgatc acgactttcc 2889541 ctttatttgc aaccgctttt ttgtaccagt cgcgttcaac cggattatag ccgcttggca 2889601 tcggaagatc cggatagcgg gtaaagtgcc cttttgtgtc acttgtataa atggattcta 2889661 catccttgtt aatgctgata tattgtgaga atttctctgc aatgcttgca ttgctttttg 2889721 cattgtattt ctcttttgtc agccattcgc tgaaataatc agcactgttt tctttttcgc 2889781 cgatgctggt gttaatgatt tcgtttaatt gctgtacatt ttccaatgcg ctccccatca 2889841 tctgtctgtc gagtgagctg ctagccgatt gatacgcaaa gatcgccaat atgacaaccg 2889901 gtatgatgag gatcgacaga aaggaaacga gaagcttccg tgtaattgat ctttgtttta 2889961 tgagttggag tatttttttc atcattcatt tctccttttt tatgctaccc ttcatatcgg 2890021 ctggaaatgg gtaaatatat acagcaaaaa agaagaaatt taacaaaagt aactaatttc 2890081 ccataaataa atagtatttt agacctatta tttgtctact ttaaattgtt ttgtcagatc 2890141 acggagttct tcagacattc tttcaagcgt cagtgcagat gaactaatct cctccatgga 2890201 tgccagctgt tcctcagctg aagcggcgat atcttggatg ccatccgagc tttccttaga 2890261 aatggcagtg atatcatttg aagctgcgga aatttcttga gctcccgctg acagctcctc 2890321 aaccgtcgca ttcatgtttt gcagctcgga agcaatttga ttggtcattt gcgatatatg 2890381 tttgaagctc tgtttagttt catccgtcat gacaagccct gtttcaactt ctttgtttac 2890441 ggactgaagc acgttcagtg atgtgtgaat ttcttttact atttcactga tcagcgattc 2890501 aatttctttt gctgagtcag ccgactgtac cgcgagcttt ctcacttcct cagcgacgac 2890561 tgagaagccc cggccgtatt cacccgctct ggcagcttca atggcggcat ttaaagccaa 2890621 aagattggtt tgatccgcaa tgccgttgat gacacgcaaa atattcgtga tatcctttga 2890681 tttgatctcc agccctttca ccacttgttc cgctgctttt acggaatggt caattgtgtt 2890741 catttggccg gctgttttct ggacgagtgt ctcccctttg cttgacactt cggttgaatc 2890801 tgcggatgtt tctgtaatca ctgctgcagc ccgcgccagc tctgccaatc cgtcattcat 2890861 ttcattaatt tgttcggttg tcgtttctat tttctcgctt tggctttcac tgccgtttga 2890921 aaattgctcg atagccatcg taatgtgctc agtggctctg cttgtctggt ctgccgatgc 2890981 agtcagctct tcagacgagg aggcaacgtg ttctactgag tctttgatcc cgtgaatgag 2891041 cgagcgaagc gagtgtgcca tatgattgaa gctctcactc agaacgccga gttcatcttt 2891101 tgaattgatt tcaatcgttt cggttagatc gccttcacta attttttcag cggatgcgac 2891161 aatgcgtctc aatggctttg tgatggatcg aatcacaaaa taaatcgccg tcattccagc 2891221 tccgatggca atcgccagaa cgattgaagc catgatcaga accctgcttg cagcatcgtg 2891281 aatctcgttt gcatacatcg tgccgctgat tttccagcct gttgtttggc ttgttgcaaa 2891341 tgccattttt ttctttttgc ctttgtacgt atattcaaag tccccgcttt tatccttgta 2891401 gagcttatca acccagtccc cttttagctc tgttcccgct ttttctccgg agtaggcgat 2891461 gactttcttg ttttggctca aaataaaagc atagccttct tttccgatat tgattccttt 2891521 cgcggtagtg actaagtcat caattttcat atcaatggcg acaacgcctg acccatccac 2891581 cgtttgacgg gcgatggtga cgaccatttt tcctgatgaa atcgattcat aaggctcagt 2891641 gacaattgtt ttgcctttat tggccattgc ttctttgtac caatctcgtt ccaaagcatt 2891701 aaagtcgctt ggcatgtcag cgtacggata acgtgtgaag tccccgtctt tgccgcttga 2891761 aaataccgca gcgacattat cattcatttg gataaattgt ttaaattcct gtttcagctc 2891821 tgttttcttt ttatcctgaa atttttctgc tgtagcccaa tcgctgaaat atgcgaggct 2891881 tttttcagta gtgctgattt tatcatcaat gatgtgatct aatatctgaa cattttcctt 2891941 tgcgctttgc gtcatctgta catcaagtga ggcaactgct gattgataag cgctaaccga 2892001 aagggcggtt atcggaacaa ttaagatcag caggaaagaa ataataagtc tccttgcaat 2892061 tgatgatctg cgaatagtgg tgagtgtttt tttcatttcc ttttgaacct tctttcaata 2892121 atttacaaat tatatcggcg gatcttcctt taaattacat tgaaaatgga ggaaaaaatg 2892181 aaaaatagtt ctaaattcac ctgttaaact aggactttat tattgtttac catataaaaa 2892241 aacagcgctt tgatagcgct gtttttcggt ttttactcga ttttaaattg tttcgtcaga 2892301 tcgcgaagct cttctgccat ctgcgcaaga gtcgtcgctg aggaactgat ttcttccatg 2892361 gaagcaagct gttcttcagc tgatgcggca atgtcctgga tgcttgccga gctttctttc 2892421 gacacgtctg caatgccgct gactgctgct gaaacatgct gtgaacggtc tgacagctgc 2892481 tcgacggtgg aattcatcgt ctgcagcttg cccgcgattt cgtttgtcat gctgaaaatg 2892541 ctctggaagc tttcttttgt attgtctgtg acaacaagtc cggactgtac ttcctgattg 2892601 acctctttaa acatgtgaag agaggtgtcg atttctgcga cgatttcttg gatcagcttt 2892661 tcgatttctt tcgctgaatc ggctgattgg acagccagct tgcgcacctc ctccgctacg 2892721 acagagaagc cgcgtcctga ctctccggca cgcgccgctt caatggctgc atttagtgca 2892781 agcagatttg tttggtcagc gattccgttg atgactctca aaatgcttgt gatgtctttt 2892841 gattttcctt ctaagccttt gacaacagct tcagcctgct gaacagattg attaatcgag 2892901 ttcatttgtc cgactgtctg ctgcacaaac ttctcacccg ttccggcgat ttccgttgat 2892961 tggatagatg cctttgtaat atctgacgat gtttgtgaga cttgctggag tccttcattc 2893021 attaagttca gctgatgaga gctggattca accttttcgc tttgctcctc gtttccgttt 2893081 gagaactgct caatcgccat cgtaatatgc tcggtggctt tactcgtctg cccggcagat 2893141 gcggtaagct gttcggaaga tgcggccaca ttgttcaccg agtcctgaat agcgctgatc 2893201 agagagcgga gagattgtcc catttcattg aagctttccc caagctctcc aagctcatcc 2893261 tttgaatgga tttcgatcgt ttcggtcaga tcccccctgc tgatcgtttt cgatgattga 2893321 acaagacgtt ttaacggttt tgtaatcgaa cgaacgataa acagaattaa aattccgcct 2893381 gccacaatgg aagcaatcag cacaatcatt cctgttgtca gcacagactt tgaggcatcc 2893441 ttaatttcat ccatatacat tgtgccggct attttccaac cagtcagttc gtttgtagta 2893501 taggtcatct ttttatcttc gttattaaga gtatactgga gttcaccgct gtcattcgca 2893561 tacattttgg ctacccagtc gcctgaaagc ttttctccag ccttatggtt cttgtgggcg 2893621 acataggttt tgttttttgt tgcaatgaaa gcataacctt cttttccgac cttgatttgt 2893681 ttcatttgtt ctaacaattt atcaatggta atatccatgg cgacaacgcc agatccgtcc 2893741 ttcagctcct gtgcaatggt aatgaccatg cttccgtcac tcgcagccac gtaaggatct 2893801 gtcacgacaa tttcaccgcc ggccttcatc gcatcctggt accaaggccg ttgtctcggg 2893861 tcgtatcctt ccggcaattt ttcttttggc gcttgtacat aagtgccgtt atctgcgccc 2893921 ccataaattc tggctactcc ttgattaata gatacatatt gtgaaaattt agctttgatc 2893981 tcttcttgat ttgatttccc tttgaatgcg gatcttttaa gagattcact gaaaaaggtg 2894041 actgctttcg ctttttctcc cagatcattt gtaacagttg tattaaatgt atcgacactg 2894101 tttttcgcat ttcccataat ttcctgatcc agctttccgc tggcgcttcg gtaagagcta 2894161 aattctaata taagaatagg gataatgaga atcgcaataa atgagacgat taatttcttt 2894221 gaaatagacg gtttcttcag ccaattgata aaagtcttca tgtcacttgc tccttcaggt 2894281 ttgatacagt atatatcggc tgcttaaaaa agttttaaaa taaaaaatgg aagaagttct 2894341 ttttggctgt cttctgcctt tttaactttc attgcccaag ctctttgcat atcttataaa 2894401 aaacaagggg ggctaaacat gattattgta tcaggacaat tgctccgtcc ccaggatatt 2894461 gaaaattggc agattgatca agatctgaat ccgctcttaa aagagatgat tgagacgcct 2894521 gttcagtttg attatcattc aattgctgaa ctgatgtttg agcttaaact gcggatgaat 2894581 attgtagcag cggcaaagac gctgcacaaa agcggggcga agtttgccac ttttttaaaa 2894641 acatacggga atacaacgta ttggagggtt tcaccggagg gcgccttgga gctgaaatac 2894701 agaatgccgc cttcaaaagc gattcgggac attgcagaga acggcccgtt ttatgcgttt 2894761 gaatgcgcaa ccgcaatcgt tatcatttat tacttggcct taatcgatac aatcggagaa 2894821 gataaattca atgccagctt tgacagaatt attttatatg actggcatta tgagaaattg 2894881 ccgatatata cggaaacagg acaccacttt ttccttggag attgtttgta ttttaagaat 2894941 cctgaatttg atccgcaaaa ggcgcaatgg agaggcgaaa atgtgatact actgggggaa 2895001 gataaatatt ttgcccatgg tcttggaatc ttaaacggaa agcaaattat tgataagctg 2895061 aattctttta ggaaaaaagg agccttacag tcagcctacc ttctgtctca ggcgaccaga 2895121 ctggatgttc cgtctctttt ccgcatcgtc cgctaaaaag ccccatcgcc tattttccgg 2895181 acgatggggt ttcaaatgcc tttcgttttc gatagaaggg ggctgtgcca aaatattggt 2895241 tcgcagccca ctccattttt tcaaggtcat ttcttgtcac gattggatcc tggctgctcc 2895301 atttgataaa gcggacaaaa tagtagcctt tgataggaac cattgtaact tttgagtgag 2895361 gccagccttc aaatacaaac tcaattttcc ctcttttttt ataagaatat tgaagaatgt 2895421 tcatatctgt cacctcagtt tatcaagtta cgttcggcaa agctcggtac gtttacatcc 2895481 attgattaac tatccctcat gcaggctttc cggaaaacaa agggtgaggc gcgtgtctct 2895541 ttccctcgct ttttatttcg catatggacg aatgccaagc acgccttcat tcgataaagc 2895601 cgcagcgtgg gcgggtgtga caagccctcc ggctatcggc gcttgttcag cgatcatgct 2895661 tttgtcataa aaaacagcct attatcccat cattttgata tagcatgtcc gggtgcgagg 2895721 cccgtcaaat tcgcagaaat aaatgccctg ccacgttcca agaataagcc ggccgttttc 2895781 cacaatgaca tgctgtgaag ctccgaccgt actcgacttc atgtgtgcag ctgtattgcc 2895841 ctccatatgg cggtccagct catgttccca cggatatacc tcatcaaacc ttctgagcat 2895901 atcttttttg acgtccggat cggcattttc attaattgta atgcccgcag tcgtatgcgg 2895961 acagtaaatc agcgctgcgc cgctcgttat acctgtttct tgaagaaacg cttccacctc 2896021 ccgggtgata tctatcattt catctcgttt ggttgttttg atttgcagtg ttttcagcat 2896081 ttgtttctcc tttcgtttgt ccgctctcat cgcttaattc gttctgtgtt cttttttttc 2896141 ctgttaaacc gctctcataa acccgataaa acaaaaaaac tccagtctaa ggctggagtt 2896201 tagcaccata gatatattct tgcttcatac ggctttaaga gtactgatgt catatgcttg 2896261 tgcggctctg tttcaatatt tgacaagacg agtgcatctg atgacaatgg caatccagag 2896321 tgcctgaaca acgccggtgt tcctgtcaga ttggccgcaa tcagtgcagt atggctctcg 2896381 tttttccgaa gatatgcaaa gatttgctga tcttccggta aaatgagctc gtatgtcccg 2896441 ttaataaaaa catcatatgt ttggcgcagc ttgatcaagc ttttgtaaaa atggtaaacg 2896501 gatgttttat cgtttttttg cgcctcggca ttcagccatt tgtaattctc attgattccg 2896561 atccacggtt tggcctcaga aaatccggcg tatggaccag cattccattg catcggcgtt 2896621 cgcgaattgt ctcttccctt tttccagaca atcttcatca catcctcgtg tgatgtgcct 2896681 ttcgctgttt ttgtttcata caggcgtttc aatgcgacat catcatagtc ctcaatagat 2896741 ggaaaagcca cgttcgtcat cccgagttcc tgtccctgat aaataaacgg tgtgcctttc 2896801 atgagaaaat aaacagcgga aagcgctttt gcactttctt tcaggtacac tccgtcgtct 2896861 ccccacacag aaactgaacg gggctggtcg tgattctcca taaacaaagc attccagccg 2896921 atcccttcca gactgtcctg ccagtcagtt aaaattcgtt taaatgcaac gatatcaata 2896981 ctttcattga tctctacatc ccacaggccg agatgctcaa attgaaaaat catgctgaat 2897041 atgccgtttt tttctccagc ccaatcagct gcttcttttg cagcgacgcc gtttgcttca 2897101 ccaactgtca taatcggata gcgggaaaat gtgttttcct tcagctctgt taacaaatcc 2897161 ataatgccgt cagcattcat atgataagga aaggaaggga catagtccag tccctttgga 2897221 ttcggcatgt caggaaaccc ttcttttttc ttaatatgcg taatggcatc cacccgaaat 2897281 ccgtcaattc ctttatcaag ccaccaattg atcatgtcat aaacggcatt cctcaccttt 2897341 tcattttccc aattcaaatc aggctgtttt ttatcaaaaa ggtgcagata atactggctt 2897401 gtcttttgat catactccca agccggcccg ccgaaaatgc tttcccaatt gttgggcgtt 2897461 tttccgtttt tgccgtcttt ccaaatatac cagtcgcgct tttccgagtg tatggatgaa 2897521 cgggattcta tgaaccatgg atgttcgtcg cttgtgtggt tcacaacgag atccataatc 2897581 agcttcatat ccagatcatg aatgtcacca agcagctcat caaaatcttc catcgtgcca 2897641 aactcgctta atatgttttg ataatccctg atatcatagc cattatcggc attcggtgaa 2897701 tcatacagcg ggcaaatcca tatgacgtca gcgcccagct cttttatgta agaaagcttg 2897761 gttctgattc cttgaatatc cccgattccg tcgccatttg aatctttaaa actgcggggg 2897821 taaatttggt aaactacggc ttccttccac caagcctttt tcatacagcc actccttccc 2897881 agtgtaccgt tcttatatat cctatgtaga aaaaggtctt tacagcattg ctttttaaga 2897941 aatgacttga tgacacaaaa aacagccgtt tgttccccgg ctgtttttta tcaaaaatca 2898001 gtttttttta tttctacaaa acggatgtgg tgatcttcgg cgtcgaggat tttaaattca 2898061 cagccctccg cgtgtatcac atcccctgct ttcagctcca ttttttgcgt tagaagccag 2898121 cctgcaatcg tatcaatttc ttcattttca atcgcaatgt cgagaaggtc attcacttcg 2898181 tctattagcg cttttccatc catcacataa tggtgctcgc cctttttcag gatgtgcggt 2898241 gtttcatcct gatcatactc atcgcggatt tccccgacga tttcctcgat aatatcctct 2898301 acagtgacaa gccccgccgt tcccccgtat tcatcgacaa gaatcgccat gtgaatccgc 2898361 tccttctgca tgcggattaa aagctgctga acaggaatgc tttcaatgac tctgataacg 2898421 ggcctcatga tttgattcag ctttatcggc tggccgagaa aataagcttt aaacatatct 2898481 ttgctgttga tgatccctaa aatatgatcc ttgtcatctt tgatgacagg gtagcgtgta 2898541 taccgttcat taatgatgtg atgaattgcc tcttcaagcg actgctccag agagataacc 2898601 gcaatttctg tccgcggaat cataatctct ctcgctaccc ggttgtcaaa ttcaaaaatc 2898661 ttatttacat agcggaattc agactgattg atttctccct tttcatagct ttcagaaagg 2898721 atcagcctta gttcctcttc gctgatgaca acctgatgct cctttaccga atgaaagcca 2898781 aacaatttca caagaaaact tgcagagccg tttaatgctt taataaacgg gtacgtgatt 2898841 ttataaaacc agatcagcgg ctttgcaatc cataagctta cagcttcagc tttttgaata 2898901 gaaaccgttt tcggggcaag ctcccccatc accacatgca aaaaagtgac gatgataaat 2898961 gcaactacaa atgtgacaat gtggttaaac ggttccggta tgcctgtcat tgtaaataag 2899021 ggatgaagaa aacgttcaaa tgtaggttca ccaagccacc caaggccgag ggctgtaatc 2899081 gtaatcccga gctggcaggc tgataaatac tcgtcaagat tggagatgat tttatgtgcg 2899141 gctagtgctc ggctgtcacc gctttcgatg agctgattga tttttgaacc tctgattttg 2899201 acgatcgcaa attccgctgc aacgaaaaca gccgtaatgc caatcaaaac aaaaatggcg 2899261 atcaattgta aaataagcaa aaaaagccct taccataaat ggtaaggggc cacctcctta 2899321 acgttaattc tcatcacgac cgtttaagaa aatcatcaca aaacgaagta gttcaaacag 2899381 ggaaaccagg gcggcggcca catacgttaa ggcagcagca ctcagcactt tatttacccc 2899441 attttcttca ttgtttcgga tgaatccttc tgacacaata atctgcttcg cacgtgaact 2899501 tgcattgaat tcgacaggca atgtaatcag ctggaaaaag acagccgctg aaaacagtat 2899561 gatgccaagc ccgatcaaat tcaggctgcc gagaagcatg cctcctaaga aaagcaaagg 2899621 agctacaccg gatgcaaaat tcacgactgg gaagatttta tgtctcagca caagcgcacc 2899681 atatgactcc tgatgctgca aggcatgtcc gacttcatgg gaagctacgg atatggcgga 2899741 aattgagcgg ccgtaataga ccggctcaga taaacgcacc acccgtcttg tcgggtcgta 2899801 atggtctgtt aaagtgcctc ttaccggttc gaccggcacg tcgtaaagac cgtttatatc 2899861 taaaatccgt cttgccgttt ctgcccctgt acgtccgctt gaggcttcca cttttgaata 2899921 tttttcaaag ttgctcttta ctttaaattg tgcccaaaac gacaatccca atgcggctat 2899981 tgttaaaaat ataaacagca ttttttcatc atcctttgtt catgatcatt tctctattac 2900041 gattatttta atgagttttc tttctcgtgt acagaaatgc gctttttctt ccggcttgga 2900101 gcacacaatc caatcagcaa aaagaacagg cctgctgaaa acaaataaaa ggcgaaactg 2900161 ccggccagtt ctttcagaaa atgaagccag gagaagcttc cggaaaagtg attatatgaa 2900221 ttcaaatcga aaataaacaa aatcaccgcg gatgccgcca gctgcgtacc gattaaaacc 2900281 acgatcgttc tttgaaagat cgtcatcttt ttcatccttt ttgttttagt ttatggagaa 2900341 atccggtttt atatgttttg tacatttttt gaaaaacatc accggaagtg ggacatactg 2900401 ttagaaaaaa gcacgggtgt gatggaagct atgaaagtga cgagtgagga aaaggaacag 2900461 ctgagcacag caatcgaccg aatgaatgaa ggactggacg cgtttatcca gctgtataat 2900521 gaatcggaaa ttgatgaacc gcttattcag cttgatgatg atacagccga gttaatgaag 2900581 caggcccgag atatgtacgg ccaggaaaag ctaaatgaga aattaaatac aattattaaa 2900641 cagattttat ccatctcagt atctgaagaa ggagaaaaag aatgaaatca aatcggatat 2900701 ttatttcatg gctcaggtgg ccgttattta tccgaatcgg ggttattatt ttatgtctga 2900761 ttcttttgtt cggccaaatc atttatatac ttgagcctaa gcagttcact tcggtattcg 2900821 aaggtatttg gtgggctgtc gttacggttt ctacagtcgg ttatggagac tatgtgccgc 2900881 acactccgct gggacaggca gccggaatac tgctgatttt gagcggagca agctttgtca 2900941 cagcgtattt cgctacgtta tcagcggccg cattcagcag acagcatcgc tacattgaag 2901001 gaaaagttgc ttacaaaggc cgggaccaca tcattctgat cgggtggaat gaaaaaacaa 2901061 accggctttt gaaggacctt cagcttgccg ccccttccaa aacagtcgta ctaatcgatg 2901121 aatccttaac agaaggcccg cttattgaaa acgttcattt catacgcggg cacgctgccg 2901181 atgatgggac actgaaacgg gccaatatta ctgaagcgga atcagtgatg attactgccg 2901241 atcagtataa aagtgaaact gatgctgata tgctgtcagt gctgactctt ttatctgtta 2901301 aaggtcttaa tccccttgct tactgcatcg tcgagatttt aactgaccgt tttgtcacca 2901361 atgcggaacg ggcaggcgca aaccaaatca tcggaacttc agaatttatc agccgggcga 2901421 tgctgcagca ttaccaagtc aagttacggc cgtctaaaca gcagaacgga atcaagctga 2901481 cacttgatca gcatgtggag cttcttgctg ttcctgacga actaaaggga gcggcttaca 2901541 aaacctgtgt tctctatttc cttgatcaca acacaacaat tataggcata caaaaaaagg 2901601 aggggccgat gctttcccct cctcttacat acaaggtgct cgaaacagat caattccttg 2901661 ccatctagtg taacagaaca tcctccaatt ctttcacgag agaggcgccg atatccaaaa 2901721 atgccggatc aatttccgcg tcccgccttt ccggttcgga aaattgatta aacagtgatt 2901781 ggaaaggccc tccctcggcg tgatcgtcaa catccgcctg aaacacctgt ctcagcataa 2901841 atggcgttcc gatccggacg gccgcccctc gttcatcgag actgccctgt accgcattga 2901901 cgggaattct taaaaataaa tagccgtctc tatcatcaat tttataatca aagtagccat 2901961 gatcgtattc ccagccgccg tttatcacat aaccgagcgg cttcatcact tgttccagtt 2902021 cttgaagcag aaaagactgc ccatctatcg cggaaggtat tggtatcatc agaatgcccc 2902081 ttttttcact tatcctgtcc cgccgaacaa gacttcattc agaggcgcct acatggaaat 2902141 cgttgtttct ttcgcgcggc caacaggaaa gaaagcgcat tcaattaaga agtaaacagc 2902201 cattgccgct gcaagccata cagctgaatc ccaagacaca taaacaaccg ttgcatagag 2902261 tcctaattta gtgaaaagag tatgggttcg ttttaaatgc aaaatccgat gtaccgcatc 2902321 ggtaaaaagg gcaagcggca aaccaatgag aagaaaggag tggatgaaaa aatgtgacag 2902381 cgtgccgcca aagcttgaag aaaaccctgt atacacggca tcaaaggaga taaggaaact 2902441 taaaatagct gcagaaaaac cggcaatgat gagatgttta accaattgtt tcatgaacat 2902501 cagcaccttt ctgattttat aaaaagccga ccggcaaatg ccagtcagct ttctcacatt 2902561 aatcttccag acgtttttca agctctgctt ttttctcttc aaagccaggt ttgccgagta 2902621 acgcaaacat attgacttta tacgcttcta caccaggctg gtcaaacgga ttgacgccaa 2902681 ggaggtaacc gctcatcgcg caggcttttt cgaagaaata tacaaggtat ccaaaagtat 2902741 atgcattcag ctcaggaatg ttaacgatta agttcggaac atttccgtct gtatgggcaa 2902801 gcattgtacc ttggaatgct tttttgttaa cgaaatcaac agttttaccg gctaaatagt 2902861 tcaagccgtc aagatcgtta tccgcttcct caattgtcag ttcatgttta ggcttctcta 2902921 cgttcaggac cgtttcgaat aaatctctgc ggccttcttg tacatactgg cctaaagaat 2902981 gaaggtctgt tgaatagttc gctgaagaag gataaatgcc cttctcatct ttcccttcgc 2903041 tttctccgaa cagctgcttc caccattccg caaagtattg aagcgccggt tcgtagttga 2903101 tgagcatttc aattgttttg cccttattat aaaggacatt gcgaacaacc gcatattggt 2903161 atgctgggtt atcttccagt tcagatgttg caaaatcttt gctcgcatcc agggcgcctt 2903221 tcatcatgtc gtcaatgttg acgccgctga cagcaatcgg caagagacct acagctgtta 2903281 aaactgaata acggccgccg acatcgtcag gaattacgaa tgattcaaag ccttcttcgt 2903341 tagaaagcgt ttttaatgcg ccgcgctctt tatcagttgt tgcataaatc cgcgctttcg 2903401 cttcttcttt accgtatttc tcttcaagaa gcttgcggaa aatacggaaa gcgattgcag 2903461 gttcagttgt cgtacctgat ttagaaatca cattaataga gaagtcaaca tcttcaagaa 2903521 gatccatgac gtctctcata taagatgaac tgatgttgtt cccgataaaa atgacttgcg 2903581 gattgccgcg ttttgctttt ggcaaagtgt tataaaacgc gtgattcagc gcttcaatcg 2903641 ctgcccgcgc tccaagataa gaaccgccga tgccgacaac aagcaagaca tcagagtcag 2903701 atttgatttt ttccgcgctt tttttgatgc gcgcgaattc ttctttatca taatgttcag 2903761 ggaggtccac ccagcctaga aaatcgctgc ccgcgcctgt tttctcatgg atattatggt 2903821 gtgctgtttt tacaaagtcc cgcaggtatg taagttcatg ttcgttgaag aaagtcaacg 2903881 cttttgagta gtcaaagcgt acatgcgtca ttgcttgtcc ctccataacg gtataatgtt 2903941 ttcatctttc actttatatg aacttatctg tgaaatcaag tcaagaagaa agggcggaat 2904001 gactggattc cgccctttgg gtttatagag acgcgcgaag gatggcaagc acgtcatctt 2904061 tgttcagttt ttggaagttg ccgaagccgc cgtgttccat ttccttggct gcgatatcag 2904121 caatcagctc aagcttttct tctccaatat tgtaatcagc aagacgagaa ggtgcaccga 2904181 ggcttgtcca gaacgcagac agtttatcga ttccttcaag cgcaatttct ttatctgttt 2904241 tgccttcagt atcaatgtca aacatgttga gcataaggtt tttaaaacgg cctacatttg 2904301 tatcaagcgt gtatctcatc caatttggga acagtattgc caaaccgccc gcgtgcggaa 2904361 tatcatatac agctgaaaca gcgtgttcca ttgtatgaga agcccagtca ccgaagtatc 2904421 ccatttggag cgtgccgttt aaagcaatag taccagcata caaaatcgtt tcacgaagtt 2904481 cgtagttttc cagatcttca agaagcttag gagctgtttc gatgaccgtc tgcaaaacag 2904541 caaagcacat tctatcctga agcggcgtgt tttcaacatt atggaagtat tgttcgaata 2904601 cgtggctcat catgtcaacc atgccgtata ctgtttgatt ttctggaacg gtgaacgtat 2904661 tttcagggtc taaaatagag aaacgcggat gagtgacatt gctgccccat acaaatttct 2904721 cgtttgtttc ccagtttgta atcacggaat cagggttcat ttcagaccct gttgcagcaa 2904781 gagttaaaac agtgccaaac ggcagcgcat cctccgctgt tacttttttg ctgaaaatat 2904841 cccaagcgtc accgtcatat ttgacgccag ctgcgattgc ctttgtacag tcaatcacac 2904901 tgcctccgcc gacagcaagc agaaaatcaa tgtcatgctc tctgcaaagt cctatgcctt 2904961 tttccactgt cgcaagacgc gggtttggct ctacacctga cagctcatga acaacagcgc 2905021 cctcttcttt taaaatgcct gtgacttgat cataaaggcc gttgcgttta atgctgccgc 2905081 ccccgtaaac aagcagtaca ttcttgccgt atcgtttgaa ttcttttctt aattgttcaa 2905141 gctgaccttt tccaaaaatc agctttgtcg gattataata agtgaaattt tccatagtaa 2905201 aacctccaaa tgatgctggt aaaaaacaga ttttccattg taacataagt tgacaaaaaa 2905261 gaaaaaggga agcagccaaa cggctatttc cccttttttt atagtgatgc tttcaaaatt 2905321 gacagcacat cttctttgtt gagtgattta aattggccga atgtaccgtt agccattgcc 2905381 ttgtcagcga ttgtgtcaag ctgctcatca ttaatatcat aatcagcaag acggttcgga 2905441 gcgccaagac ttgtccagaa tgcggacagc ttatcgatac cttcaagggc aatttcttca 2905501 tccgttttac ctgcttcttc aacatcaaac acgcgaactg caagctgttt catgcgggca 2905561 gggttttcag acaatgtgtg tctcatccaa ttcgggaaca gaatcgccag tccgccggca 2905621 tgcggaatat cataaacggc tgatactgca tgttcaatat tatgagtagc ccaatcccct 2905681 cttgccccca tagaaagcat gccgtttaat gcgattgttc ctgtgtacag gatcgtctca 2905741 cgcaattcgt aattttcgag atcattgatc agcttaggcg ctgtttcaat gactgtacgc 2905801 aaaagtgatt cacacatgcg gtcctgatac ggcgtgtttg atacatgatg gaagtattgt 2905861 tcgaatacgt ggctcatcat gtcaaccatc ccgtagatcg tgtggttttt aggtacggtg 2905921 aatgtattca ccggatcaag aatcgagaat ttagggaata cgagcgggct gccccagccg 2905981 tatttttctt ttgtttccca gtttgtaata acagatcctg agttcatttc tgaaccagtt 2906041 gcagcgagag tcaataccgt tccgaatggc aaagcatctt ttggctgatg ctttttcgta 2906101 acgatatccc acgcatcacc atcatacttc gctcctgcgg caatcgcttt tgtacagtcg 2906161 attacgcttc cgcctccgac agccagcaag aaatcaatgt tttgttcttt acagatggca 2906221 acacctttat taacagtcga cacacgagga ttcggttcca cacctgctaa ttcatgcacg 2906281 gtcgctccgg ctttattcag ctgttcaatc acttgatcat acaggccgct gcgtttaatg 2906341 ctgccgcctc cgtacacaag caatacgttt tttccgtaag gtttgagttc ctccggaagt 2906401 ctttccactt cgccgcgccc gaaaattaat ttggtcggat tccagtatgt aaagttttgc 2906461 atgacatctc ctccttagat tttttattat gcagaatgtc ctcaccacat gtaaagcaat 2906521 cagctctcac cgatcagcat accagatggt tttattttgc aaggtgctgg gaaagaagct 2906581 gatataagcg agggcaggcc agcttccctc atatggagaa tgcatgtata gattctccaa 2906641 tatgtcacaa tctataactg ttttaataat tcatggagga ggttgcaaaa catgagtacc 2906701 attcaaagaa tttgtcttgt attaaccatc attggcgcca ttaactgggg actgatcgga 2906761 tttttccaat ttgacttagt agcggctatc ttcggcggcc aagggtcagc tctttcccga 2906821 atcatttacg gacttgtcgg aatcgccggc ttaatcaacc tcggtctgct atttaagcca 2906881 aacgaggaaa gatcacgtga agaagcagca aatcctgaaa tgcgatagga tatcaatcac 2906941 gctgaaatag gattttgcat gaaatcaaaa gcaccgaaca ttcctgtccg gtgctttttt 2907001 catgcttatt ttttgataag gtctttgcgg ttggacattt cgatccactc ttcaagctta 2907061 tcttttaatg tgttgaaacc ttgtggtgta gaagcttctt cgcttacttg agcagcttta 2907121 ggttttcttg gtttgctttc ttttttctca ggcgcagctt gtgtcgcacg aattgaaagg 2907181 ctgattttgc ctttttcttc atcaacagca agtactttta cttgtacttc gtcgccaact 2907241 gaaaggtgct cgttgatatc ttttacgaaa ccgtgagtca cttcagaaat gtgtactaaa 2907301 ccttgagttt cttcatctaa tgcaacaaac gcaccatacg cttgtaatcc tgtaacttta 2907361 ccagtgtaaa cactgcccac ttcaaatttt gctgccattc ataacaactc ctaagttaaa 2907421 ttaaatatct gtttatacgc aatttaaaat tatatcacac atgtcttatt tccgcaaaga 2907481 aaactttttt ataaaaaatc aggtttatgc acagcaaaaa gggggtaaac tgaaaatacc 2907541 aaaggctttc tagtattccc cccttttatt ggatgcgaac aaaaggttcg tatctttttt 2907601 tatgttgttt tgtgcaggaa gcgtttcatt ctgactaacg cttcttgaag ctgttcaatc 2907661 gaggttgcgt atgaacaacg gatatatccc tcaccgctcg gaccaaacac acttccagga 2907721 acaactgcca ctttttcctg cgtcagtagc tcctcggcaa actgttctga actcattccc 2907781 atgcttttga tagatggaaa agcatagaaa gcgccgcccg gatgatgaca gctgagaccg 2907841 atttcattga gcgattctac aaacagattc cgtcttcttc gatagctttt tttcattttt 2907901 tctacgtctt ccatgccgtt cttcaggcct tcaagggcgg caaactgcgc cattgcgggc 2907961 gcgcacatca tcgcatactg atgaatttta agcatggcat cccgaagcaa ggatggtgcc 2908021 gcggcaaaac cgagcctcca gcccgtcatt gcaaatgctt ttgaaaagcc tgagatgact 2908081 accgtccgtt ccttcattcc cggtaatgcc gctatacttg taaattcctc atcatatgtc 2908141 agctccgcgt agatctcgtc ggctaagacg atgacatcat gttttttggc aaactcagca 2908201 atctcattca gctcttcctt cgaataaacc gaacctgtcg gattcgatgg tgagcagatg 2908261 agaatggcct ttgttttttc agtgactgcc gcttcaaaat cagcagccgt tgctttaaat 2908321 cctttgtctg ccgttgtatg aacgtgaacc gggataccgc ctgccaaaga aacaagcgca 2908381 tcgtacgcaa caaaacacgg ctcaggaatg atgacttcct cacctggatt cacaatggcg 2908441 cggatcgcaa tatccaaagc ctgacttgcc cccactgtca caatcagctc attatctggc 2908501 gagtagctaa ggtcaaacct gttgctcaaa taacggctga tttcctcccg caatgagtat 2908561 aaacccgcat tggccgtgta tgacgtatat ccttgttcaa gagagagaat gcttgcttcg 2908621 cggacattcc atgcggtaac aaaatcaggc tcgccgacgc ctaaagaaat gacgccttcc 2908681 atcgttgccg ccaaatcaaa gaatttgcgg atgccggatg gttttatttg ttgtacatag 2908741 tctgataaat acgaagtcat ttacggtgac accacgattc ttttgtcgtc gtctcctgtt 2908801 tcaaacactt tgccgtcatg cttgtatttt ttcaggataa aatgggttgt cgtagataca 2908861 actgaatcaa gcgttgagag tttatccgaa acaaaacgcg ctacgtcaga catcgaattg 2908921 ccgcgaatca cgacagacaa atcgtatacg cctgacatca ggtaaactga ttcaacctct 2908981 tggaatcggt aaatccgttc cgccacttca tcaaaaccga cgccccgctt cggcgttact 2909041 ttgacgtcaa tcatggccgt aacgccctca tgtccgtcga cttttcgcca gtcaatcata 2909101 gcggaataat cgataataac cttttctttc tccagtttgt caataattgt tttcacttca 2909161 tttacaggga tgcccgccat ctttgcgatt gtttctaaat cggcgcggct gttttcgtct 2909221 aaaatttcta atatttctgt ttctttttct gtcaatttca tttgattcac acctttgcaa 2909281 tgtcaagaaa tctcatgaca ttatatcacg ttttttgacg aatgctaaga aaaaacgagg 2909341 agaaacttcc gctagaattg acaatttcag ggcataatac aaccatcaaa aaaagggagt 2909401 gacacagaat ggaggcggtt tcaccaataa ggcggtttac ggtcgatgga gtcaatgtat 2909461 actacgaaca ttatcaaaat cccggcaggc aaacgctggt ctgcgtacac ggttttttat 2909521 catctgcatt cagcttcaga aaagtaattc ctctccttcg ggacaagtac gacatcatcg 2909581 cgcttgattt gcctcctttc ggccaatctg aaaaatcaag aacgtttatc tatacctatc 2909641 aaaaccttgc taagcttgtc attgggattt tggagcactt gcaagtgaaa caggctgtgc 2909701 ttgtcgggca ttctatgggc gggcagatat cgctgtctgc tgctctccaa aaacctgagc 2909761 ttttttcaaa ggttgtgctg ctttgcagtt cagggtattt aaaacgttca cacccgacga 2909821 ttattttcgg gacccatatc ccgtattttc atctttacat caaacgctgg ctctcgaaag 2909881 aaggcgtgat gaaaaattta ttaaatgtgg tgcatgacaa atcgctgatt gatgaggaga 2909941 tgattgacgg ctatggcaga ccgtttcagg acgagcagat tttcaaagcc atgacaaggt 2910001 ttatccgcca cagagaagga gatttagaac ccgagcaatt gaagaaaatg aacaagcctg 2910061 ctctattgat ttggggcgag gaggatcgaa ttgtcccaat ggagatcggt aaacggctgc 2910121 acgcagattt gcctaattcc gtgctgtact cacttggcca gaccggacat ctggtgcctg 2910181 aagaacggcc tgaacttatt tctgaacaca ttgctgattt tatcaaataa caaaaaaacc 2910241 ggtgctgaac cggttttttt aaggcgtgca ggagctgctg tttttaatga ataaaagctg 2910301 gccagccact tcccggcagc tggcgatcgg cagcgtttgt tcaaaagaag tttcaaatat 2910361 ttgctgaatg cttttcgcca gcaagtcggg atcgttttca tcatagactg cctgcacgac 2910421 atcaacagcc tccgtttcgt aaaactcttc tccatattta aacgggtccc atttggcaat 2910481 gatcttaatc atttccctga ccgcatgact ttcttccata ttcatcaccg cttataataa 2910541 aatttgcagt tctatcttat catagtgaag cttagaagaa taaacataca tgagggggta 2910601 acagaatgaa ctttgataaa cgagaagaac gccttggcac ccaatcggtc aaatgggata 2910661 aaacaggcga attatttggc gtgacagacg ccctcccgat gtgggtggca gatatggatt 2910721 ttcgcgcccc ggaagcgata actgaagcgt taaaagagcg tcttgaccac ggtatttttg 2910781 gttatacaac tccagatcaa aaaacgaagg atgctgtgtg cggatggatg caaaacaggc 2910841 acggctggaa ggtaaatccg gaaagcatca cattcagccc cggcgttgta acagctttga 2910901 gcatggcggt acaagctttt acggagccgg gcgatcaagt agttgttcag cctccagttt 2910961 atacgccttt ttaccatatg gtggagaaaa acggccggca cattttacat aatccgctgc 2911021 tagaaaaaga cggcgcatat gcaatcgatt ttgaagattt ggagacaaag cttagtgacc 2911081 caagcgttac attgtttatt ttatgcaatc ctcataaccc ttctgggcgt tcatggagcc 2911141 gggaagattt actgaagcta ggcgaattgt gccttgagca tggcgtcaca gttgtatcgg 2911201 atgaaatcca ttccgattta atgctgtacg gacataaaca cacgccgttc gcttcgctct 2911261 ctgacgattt cgctgatatt tccgtgacat gtgctgctcc aagcaaaaca tttaatatcg 2911321 ccggattgca ggcttcagcg atcattattc cggatcgcct gaagcgcgcc aagttttccg 2911381 caagccttca gcgaaatggt ttaggcggac tgaacgcgtt tgccgtcact gcaatcgaag 2911441 ccgcgtattc aaaaggcgga ccgtggcttg atgaattgat cacttacatt gagaaaaaca 2911501 tgaacgaagc ggaagccttt ttgagcaccg agctgccaaa ggtcaaaatg atgaagccgg 2911561 atgcatcata cttgatttgg ctcgacttca gcgcttacgg cttgtccgat gcagagcttc 2911621 agcaaagaat gctaaaaaaa ggaaaagtta ttttagagcc cgggacgaaa tacgggcctg 2911681 gcggagaagg atttatgcgc ctgaacgccg gatgctctct tgcaaccctg caggacggcc 2911741 tgcgccgcat caaagccgca ttatcgtaaa tatagctgta aacgccttta cgtcttcatt 2911801 tgtaaaggcg ttcttaataa aggaatttta tattttactt ctaatattta gtgttataat 2911861 agattcatat tttatacgaa aggatttcac acgaatggaa attctaaaag actatcttct 2911921 gcacatctgc tttattttgt ttcctattct tctttaccaa gtgttttggc ttggaaaacc 2911981 tgcgattctt gtgccaaaaa taaacagcgg tttggtcacg ctcttcgcct gcggcgcctc 2912041 cgttttatgc attattttcc cgattcatga aatggactac atacaatacg gccttcagat 2912101 gattcccgtt atcatttgtt tattttacat tagtaccgct tccggactta cagtcgccgc 2912161 atctgtccta tgttttgaac tgctttttta cgaaccttcc gcaatgtttg ttttcacttt 2912221 gctgcctttt cttatcatta tcccaatctt atttcagaaa aaatggccat tcatgtccaa 2912281 agcgaaaaaa ctgctgctgt ctttattgat cagctgcgtg gagattttcc tatttttcgc 2912341 ctcaagctgg attctttccg ccttgaatat tttaaatttt caaaaatcag gaattttcgt 2912401 ttacgaggcg gcagtctcag ggcttttccg ctccagtgtt cttctattaa gcatctatat 2912461 tatcgaaagc atcgccgaaa atatcgccct gcgttcacag cttatccatt ctgaaaaaat 2912521 gacgattgtg agtgaactgg cagcgagcgt cgcccatgag gtcaggaatc cgctgacagt 2912581 tgtccgcggg tttgtccagc tgctttttaa tgacgaaacc ctacaaaaca agtcgagtgc 2912641 ggattacaaa aagcttgtac tgtcagagct tgaccgggcg caaggcatta tcacaaacta 2912701 tctcgatatg gccaaacagc aattatacga aaaagaggtt tttgacctat ctgcccttat 2912761 caaagagaca agctccctta tggtgtcgta cgccaattac aagtcagtaa ccgtcgaggc 2912821 tgaaacagaa ccggaccttt tgatatacgg agacgcaaca aagctgaagc aggctgtcat 2912881 caacctgatg aaaaacagta ttgaagcggt tcctcacggg aaggggatga tccacatatc 2912941 agccaaaaga aacggccata cgatcatgat taacatcaca gacaatgggg tcgggatgac 2913001 agaccatcaa atgcaaaaac tcggcgaacc ttattattcc ttaaaaacga acggaacggg 2913061 actcggcctc accgtaacct tttccattat tgaacatcat cacgggacca tttcatttaa 2913121 cagcagcttc caaaaaggca ctacggtgac cattaagctt cccgctgatc ttcctcacta 2913181 gcaaatcgat tggaacttta atagaataaa tgcgaggtga tgacagatga gcacgtttga 2913241 gacaggctct atcgttaaag gattttacaa aacaggtgta tacataggag aaatcacggc 2913301 ttgcaggccg cagcattatt tagtgaaagt gaaagcggtt cttacccatc ccgctcaggg 2913361 agaccttcat catccaaaac aggcggatgt gccatttttt catgagagaa aagcgctcgc 2913421 atatggtgaa cagaccaata tcccccacca tatggtgaag ccttatgacg gtgaagtgcc 2913481 ggattatacc gaatctctgc gggaggcgac agcacagatg agagccaaat tgaatgagga 2913541 tggttcggag tgggcaaagc gctcccttca taatctggac attttagaaa aagaatattt 2913601 taaccggcca taacccagtc tgacaaaaga ttgggttttt tacgtcgcgc gcttcaacag 2913661 ttcggttaaa tcgattctct cgccgattgt gggcggtttt ggcttttcga gatactgctt 2913721 atcctgctca acaagcttaa aaagtttata tgctgtgaga gcatcatcaa gcgctttatg 2913781 atgggtgccg gttccggaat ctccatactc ttcggcagct ttccataaac ccgtcaatgt 2913841 ccggtctcca aaaaagtttt tgtattcaag cgataaatct ctcatttctc ccttaaacgg 2913901 gaaagggata tggttaaaca tacagttttg cttcagcact ttcatatcca tgtttcccca 2913961 cgtaataatt gtgctgtttt tctcaggatc cagctcgttt agtttacgga tgaaatcctc 2914021 gaatctcatt ccttcgtcta cctgtttttg ggttattttt aaaaatgatt tgcagcgttt 2914081 cgtaagcttc gggaactttt tcggtctaac atagctagaa aacgtctcaa ccacttcatc 2914141 atcaatcgac tttacaattc cggcttcaat gatttccggg aagaagtttt gaggactgta 2914201 ctttccatca ggcattgtaa attcgaaatc aataatgagt aagctgtttg tcgtcacctt 2914261 ttacacctgc ctttcctccg atcagaaaat gctatcttta tagtatatca attccccttc 2914321 tcgacatttc ttcattttct aaaaataatg aattttccca gccgcttcgt ttcttttaaa 2914381 ttgtgaatcg tttctttata attagtaagg aacccgaaat aataagaagg tgatgttatt 2914441 tctatccgta agaaaaactt tgtcattgtg tggctggcga acttttttgt ctccgctagc 2914501 acaacgatga tcgttccttt tctctcctta tacattgaga cgctcagctc tttttcaaac 2914561 ggctttgtgc aaaggtggag cggctatgtg ttcggcatta catttctcat ggcgtttttg 2914621 gtatccccgt tttggggacg gttcggagac aaacgcggat acaagaaaat ccttatggca 2914681 accggaacag gcattgccct cagcattttc ttcatgggct ttgttacatc ggtgtaccaa 2914741 ttgttttttc tgcgtatggc aatgggtctt gtaaccggat tcatcccgac atctcttgcg 2914801 atgatttcgg cacagactcc gaagagctca gctggcaaaa cactcggcac gctgcaaatg 2914861 gggcaagtgt ccggaagctt gttcggcccg cttttgggag gcatgcttgc tgatcgtttc 2914921 ggctttacgt ataccttttt tatcacatcc tttgtgattt tctcgtctgt tcttctcgtg 2914981 ttatttggtg tcaaagaaaa gcatcttgca gagaaaacag ccaaacgtac gtcttactcg 2915041 agaaaagaag tgctctccta tatttttcac catccggcgc tgtgggtcat gatgctgtta 2915101 accatgctga ttcaaacagg caatttcagt atccagcccc tgctcgcttt atatgtaaat 2915161 gagctgcacg gacctgtcaa tcttgccttt ttctccggca tggcattttc agcaacgggg 2915221 ctcggaagtt tgctgctggc tagaaaatgg ggtgatctgg gcgaccgcta cggccaccgc 2915281 cgcattttaa tcggactttt gctcgccgcc tctttctttt ttattccgca ggcgctcgcg 2915341 tcctcactca gcgtgctcct tgttttcaga tttttattcg gaatggcgat gggcggtttg 2915401 ctgccatgca ttacggcagc gatccgcgtt caggctcccg gcagcattca aggtgaagtt 2915461 ctcggctaca atgtcagctt tcgcttttta ggaaacgtgc tcgggcctct gctcggcgga 2915521 atcatatcga gccattttac catttcggcc accttttacg tcacggcgtt tctctttttc 2915581 gccggcgcct gcatgctttg gatcatgcag aaacttcgga aagattctta tgccaaagca 2915641 agctgattcc gagaaaaaac taaggaatct tctaaattta accttctcgt aatctcaaaa 2915701 gaatggtacg atatggctag aatttaggag aaaagagagt gaccatgtta cgaaaaataa 2915761 tcggatggat tttgctcctt tgcataatcc cattgtttgc atttacagtt atcgcttccg 2915821 gaaaagaagt aaaacaaatg aagtccctgg atcaggtgct tgataaaaat attgatctga 2915881 aagatatcag ccttgttcag aacagctaca tgtatgacag ggacggctcc cttgtctcgg 2915941 aaatcgtcag cgaccacgaa aaccgtgtgc tcgttccatt taacaagatt cccgaggaag 2916001 tcaaacagat tttcttaaca tctgaggacc gccattttta cgagcataaa ggctttgact 2916061 ttatgggaat ggtgcgggct actgcttcta acgtaaaaga caagaaaatt gaccagggtg 2916121 ccagcaccat cacacagcag ctttcaagaa acttgtattt gagccacgaa cgctccttca 2916181 gccgcaagct gacagagctc gcgtattcct atcagctgga gaaaaaatat acgaaaaatg 2916241 aaattcttga agcttactta aataccattt atttcaacaa cggtgtttac ggcgtcggtt 2916301 cagcagctca attctatttc agcaaaccgc tgaaatctct cacagtggga gaaatggctt 2916361 ttatctgtgc tatacctaat aaccctacat tatatgatcc tctcaagcat tttgactaca 2916421 cgaaaagccg tcaagaacgt ttacttaaag ggctaaaaga tgccggggtc attacggaca 2916481 aagagctgaa aaaagccgta aaacaaaaaa tcaaactgga tgttgaaaaa agagaagaca 2916541 aatatcctga ctacgtttcc tacgtcaatg atgaattcac tcagctggtg tctgaatcag 2916601 aaggctttga taaacgcctt caaaaagcat caggaaaaca aaaagaaaag atcgagaacg 2916661 agctgtccgc aagagtcagc acgctgatga aagacggagt gaaaatttat actgcacttg 2916721 atccgtacat gcaaaatcaa gttgtggcac aaatgaattc caagctcccg tatgcggacg 2916781 tacagggcgg agcggctgtg attaatcacc agacgcatca aatcattgct ctatccggcg 2916841 ggaaaaacta tcaaaaatat gactttaacc gcgcctacca ggcgtacagg cagccgggtt 2916901 catccattaa gccgcttctt gattacggcc cttatattga acagaccggc gcgacaacaa 2916961 gcagcaccat tgatgccagc aagttttgca gcaaagacta ctgtccgcaa aactacaata 2917021 accgcactta cggcacagtg acgcttgata cggcgtttaa aaattcatat aataccccgg 2917081 ctattagaat gctcgaccgc gtcggcatcc aaaaggcatt cagttatatt gagccgtatc 2917141 attttgccaa acttgtcgac agtgactatc ttcttccggc ggcgcttggc ggatttacaa 2917201 acggcatgac gcctcttgag atgacaaagg cttatacgac attcggaaac agcggaagct 2917261 atacgccgag ccatgcgatt acaaaggtga cagaccttaa aggaaaaaca ctttataaat 2917321 ggaatgataa agcgactcaa atattcagcg tccgcacgaa catgcagctg aaaaaactga 2917381 tgtcttccgt tgtgaaaagc ggaacaggga aaaaagcata tttcaatgcg ccttacatcg 2917441 gcggtaaaac cggaacatca aatgattatc acgatatgtg gtttgtcggc ctgactgata 2917501 cgtatacaat gggtgtctgg gtcggaaagg atacaccgac cagcgttgaa tatcttcaca 2917561 gcatcagccc tcagctttcc atctggaaag gaacgctgca agcggcttat taaaggatcg 2917621 gaggggatat ggagtgactt cagaacaaat tccaaatcgc gttttgctgt ttgacggtgt 2917681 ctgcaattta tgcaatggcg ccgtgcagtt tatcattaaa cgtgatccgg acggattgat 2917741 ttctttcaca tcgctgcagt cggaaacagg acagagcctg ctgaaaaaaa gcgggcttcc 2917801 gactgatcgg tttgacagct ttgtctttat tgaagacggc caagtgtaca caaagtcaac 2917861 tgcagccatt aaggttttca ggcatctgcg aggcccatgg cggctcttcg tccttttttt 2917921 cgcagtgccg aagcctgtca gagatatggt ctattctttc attgccaaaa accgctataa 2917981 gtggtttggc aaaaaaaatg aatgtatgct cccctcccct tccattaaaa aaagattttt 2918041 accgtaaata aaaaatggct aggaagctag ccatcacaga ttgttgacaa aatcctaaaa 2918101 cggcttcgtt ttaggatttt gtcatctatt cagcgtgatt gaaaactttt gaagttgtga 2918161 aacggcggaa acctgagaat ctagccgccg tttcattgcg tacagagcac gaagcgcaaa 2918221 tctgaccacc aaacgctgaa atggctagct tacacaggta agctagccat tatgctatta 2918281 taaagcttga taaatatgaa cagaataccg ataacaaagg taaaccaaaa cagcagttcc 2918341 aatagaatga atccaactaa tgacatgaga gaaagcgtcg aataaatccg gtatacggta 2918401 aacacaaagt aagcgagcgt gacgaccgca aaccagatca caatccaaat gacattttgc 2918461 aagagcacaa aggataaaat cccgccgccc aaataaatca tggaacccat tctgagtttt 2918521 ttcaggttgt tcccttccgg atcattagca aaaaacagca atgacagctc ggtcacggta 2918581 tttgcaatta atttcagagc ggacagaacc ataaaatata aaagtgcaaa ggcagcaaat 2918641 aacgcaagcc tgattccttt ctctgaaaaa taatcgagca ttccatcata cattccaaat 2918701 gaagacagca tcttcaacgc ataaagtgaa gttgagatgg ataaggacga actaaaaagc 2918761 aggatcgcaa tcagcggaaa atatcctgtc aaataagtat ttttcatata aaaaagtccc 2918821 tttctataat ctacctcatt tattatggag gacttaaaac acattgacaa gataaattat 2918881 tccatttttt ctccttttta cgaattacgg gcccaaatct tcacaaagca gcattttgag 2918941 agtaaagtag tacgcaggaa tcataaaacg taaggaagtt ttatatgaaa aaaacattaa 2919001 aactgcaaac cagactcacc atatttgttt gtatcgttgt attaatcgca ttgctcatta 2919061 cgttttttac agtcggtgcc caaaccacca aacgaattag agatcaggaa aaggccactg 2919121 cgctgcagac tgctgaaatg gtagctgaag cgccgatgac agccgctgct ttagaaagcg 2919181 gaaaaaaaca aaaggaactg cagagctaca caaagcgggt tcagaaaatt accggcacgg 2919241 aatttgttgt cgtcatggat atgaacggta tccgcaaaac tcatcctgac ccgagcaaaa 2919301 tcggaaaaaa attcagaggc ggtgatgagt ccgaggtatt aaaagggcat gtccatatca 2919361 gcacagcctc tggcacgctc gggaaatcgc agagagcgtt cgtccctgtc tacgcggaga 2919421 atggaaaaca ggtcggtgca gtcgcggtcg gcatcaccgt aaatgaaatt gatgaagtga 2919481 tcagccatag cttacggccg ctttacttta ttatttgcgt cagcatcttc gtcggtgtga 2919541 tcggagccgt tatcgtcgcc cgtacagtga aaaatatcat gtacggactt gaaccttatg 2919601 aaattgcgac tctgcttgaa gaacggagcg cgatgctgga atcgacgaag gaaggaatac 2919661 tcgctgtcga tgaacatggc aaaattaaac ttgccaacgc ggaagcaaaa cgcctattcg 2919721 tcaaaatggg catcaacaca aatcccattg atcaggatgt agatgacatc ttgccgaaaa 2919781 gccgcttgaa aaaggtcatt gagacaaaaa aacctcttca agacagagac gtccgcatta 2919841 acgggctgga gcttgtgttt aatgaagttc ctatccagct gaaaggacaa actgtcggag 2919901 cgattgcaac attccgcgac aagaccgagg taaaacattt agctgaacag ctttccggtg 2919961 ttaaaatgta tgcaaacgca ctgagagcgc agtctcatga atttatgaac aaactgcatg 2920021 tgatattagg tctcgtccag ctgaaagagt atgatgatct tggagattat attaaagata 2920081 tagccataca gcaaaaatca gaaacaagtg aaattataaa tgatgtcaaa agctccgtac 2920141 tggccggttt tctgcttgga aagcaaagct ttatacgtga gcagggcgca aatcttgata 2920201 ttgaatgcaa cggtgtcatc ccgaacgcgg cagacccttc tgtcatccat gaacttatta 2920261 caatcatcgg aaatctcatc aacaatggct tagatgccgt tgccgatatg ccgaaaaaac 2920321 aaatcaccat gtccatgcgc ttccataaca gcatacttga tattgaaatt accgatactg 2920381 gagcaggcat gtctgaagaa gaccaagcca aagtatttga acaaggctat tcaacaaagg 2920441 gcaaaaaccg gggattcggc ctttatttca cacagcaaag catcgaaaat ttaaaaggcc 2920501 aaatgatcct cacaagcgaa aagaatgaag gaacgacatt cagtattcgc atcccgtacg 2920561 aaccgaagga ggaaaatcat gattaatgta ctaatagttg aagatgaccc catggtgggt 2920621 gaattaaata aacgatactt aagccaaata gatggctttc agctgaaagg catcgcttct 2920681 tcctttcaaa gcgctctgca tattttaggg gagcaccata ttgacctcat tttgcttgat 2920741 atttatatgc cgggaaaaaa cgggctggaa ctgctgacgg aattgagagc ccaaaatgaa 2920801 gcggttgacg tgattgtcat ctcagcggcc agcgagcttg acgtgatcaa gaaaacactt 2920861 cggtacggag ctgttgatta tttaatcaaa ccgtttgaat ttgaacgatt ccaaacggct 2920921 ctgtctgatt acagacgaaa acaaaaggtg tattcaaccc atcgcaacat gagccaaaaa 2920981 gaactggacg ccgagctttt tcaaaagaaa gaagcaacag aaaaagtgca gcttcctaaa 2921041 ggcctgacaa aaagcacgct gaagctgatc tggtccagta tccagtcatt tgaaaatgaa 2921101 tcttttacga cagaagactt ggcaaagcac acagaaatct ctcaagtatc catacgaaaa 2921161 tacttaaagt ttcttgaaga tatacaggtt ctgaatgtag aaatggcgta cggaacgatc 2921221 ggaagacctg tgtttcagta caacgtcaac aacagtaaca ttaacggaat aaagcaatat 2921281 ctataagaaa acgcactgct tgctttgagc agtgcgtttt tctgtcatat ctcttgccaa 2921341 gatgcttgat tctattgttg ataagttata caagaataac aaagggcttt cacattttta 2921401 agcaaataat tctaaaaata gataattttt aaaaaattat gcgaaattct atttatttct 2921461 tattagttaa atgataaatt atgattggtt agttgatccc gaaaaactaa gtcataagtc 2921521 ttacttcaga aaacgatgtc acggttttcc gcccggaacg ccttccgcat ccttctcttc 2921581 cccgcctttc gaaggaaata ctcacaccac gcttattcag ggaagaatag aactgtctca 2921641 gcgcattcca tttgttatta tcagaaaatt ttatcgattc taagaaattg ttcaggacag 2921701 cccatcacat gactggccgg atcagctttg aaccaaattt ttctgggggg ttatatcttg 2921761 aataaacgaa aaatcggatt ggcgatgtca cttgtgatcg cagcaggcac catattagga 2921821 gcatgcggaa acagcgaaaa aagcagcggc tcaggcgaag gcaaaaacaa attcagtgtg 2921881 gcgatggtta ctgacgtagg cggagtggat gacaaatcct tcaaccaatc agcctgggaa 2921941 ggcatccaag cctttgggaa agagaatggg ctgaaaaaag gcaaaaacgg ttacgactat 2922001 cttcaatcca aatctgatgc agactataca acgaacttaa ataaattggc gcgtgagaat 2922061 tttgacttaa tttacggcgt cggctactta atggaggatt caatcagcga aattgctgac 2922121 cagcgtaaaa atacaaactt tgcgattata gatgctgttg tcgataaaga caacgtcgca 2922181 agtattacgt ttaaagagca ggaaggctca tttctcgtcg gagtggccgc agccctatca 2922241 agcaaatcag gaaaaatcgg ctttgtaggc ggcatggaat cagagttgat caaaaaattc 2922301 gaggtcggct tccgtgccgg cgtgcaagca gttaacccta aagccgttgt agaagtgaaa 2922361 tacgcagggg gtttcgataa agccgatgtc ggtaaagcaa ccgccgaaag catgtataaa 2922421 tcaggcgtag atgttattta tcactctgcg ggcgccactg gcacaggcgt ctttactgaa 2922481 gcgaaaaacc tgaaaaaaga agatccaaaa cgcgatgtct gggtcatcgg tgtcgataaa 2922541 gaccaatacg cagaaggcca ggtagaagga acagatgata acgtcaccct cacttccatg 2922601 gtgaaaaaag tagatacagt cgttgaagat gtaacgaaaa aagcgagtga cggaaagttc 2922661 ccgggcggcg aaacacttac ctacgggctt gatcaagacg gagtcggcat ttctccatct 2922721 aaacaaaatc tatcggatga tgtgatcaaa gcggtcgata aatggaagaa aaaaatcatc 2922781 gacggattgg aaatcccggc aactgagaaa gagctgaaaa ccttcaaagc tgaataagaa 2922841 tcgcagggat aaggaggtcg agcccttatc ccttgttttt cttttatttt gaaataaagg 2922901 agcggtcaat caatggaata tgtcattgaa atgctcaata tccgcaaggc gtttccaggt 2922961 atcgtcgcca atgacaatat caatcttcaa gtcaaaaaag gcgaaataca cgcgttgctc 2923021 ggtgaaaacg gagcggggaa atcaacattg atgaatgtcc ttttcgggct gtatcagccg 2923081 gagcggggtg aaattcgggt gcgcggcgag aaggtgcaca tcaacagccc gaacaaagcg 2923141 aatgaccttg gaattggaat ggtgcaccag cactttatgc ttgttgacac ctttacagtt 2923201 gctgaaaata ttattctcgg gaaggagcca aagaagtttg gcagaattga ccggaagcgt 2923261 gctggccaag aggtgcagga catttccgat cgatacggcc tgcagatcca tcctgaagca 2923321 aaagcagctg acatatcagt cggtatgcag cagcgcgcag aaatattaaa aaccctctac 2923381 cgcggtgccg acattctgat ttttgatgaa ccgacggctg ttttgacgcc tcatgaaatt 2923441 aaggaactga tgcaaattat gaagaacctg gtcaaagaag ggaagtccat catcttaatc 2923501 acccataagc tgaaagagat tatggagatt tgtgaccgcg ttacggttat ccgtaaagga 2923561 aaaggcatca aaacccttga tgtccgtgat acaaaccaag acgaactcgc cagtctaatg 2923621 gtcggccgtg aggtatcgtt caaaactgaa aagagagctg ctcagccggg agcggaagtg 2923681 cttgcgattg acggcataac tgtaaaggat acccgcggaa tagagacagt cagagatttg 2923741 tctctttctg tcaaagcggg agaaatagtc ggcatagcag gcgtcgacgg aaacgggcaa 2923801 tctgagctga tcgaagcggt gacaggactc cgcaaaacag attcaggaac aatcacctta 2923861 aacggaaaac agatccaaaa cctgacgcca agaaaaatca ctgaatccgg gatcgggcat 2923921 attcctcagg atcgccataa acacggtctc gtccttgatt ttccaatcgg agagaatatc 2923981 ctgctgcaaa gctattacaa aaagccgtat tcagcattgg gcgttttaca taaaggcgaa 2924041 atgtacaaaa aagcacgcag cctgatcact gagtacgatg tcagaacgcc ggatgaatat 2924101 acacacgctc gggcattgtc aggcggaaac cagcaaaaag cgattatcgg gcgggaaata 2924161 gaccgaaatc ctgatttatt aattgccgcc cagccgactc gcggccttga tgtcggagcg 2924221 attgaatttg tccataaaaa gctcattgag cagcgtgatg ccgggaaagc cgttcttctc 2924281 ctctcgtttg agcttgaaga aattatgaat ctcagtgaca gaatcgccgt tatttttgaa 2924341 ggacgcatta tcgccagcgt taatccgcag gaaaccactg aacaggagct tggtctcttg 2924401 atggcaggaa gcacgcaaaa ggaagcgggg aaagcaaatg gttaaacgac tctctcattt 2924461 actcgtgccg ctcatcgcaa tcatacttgg tcttgcggcc ggcgcgttga ttatgcttgt 2924521 gagcggctac agtgtggcta gcggatattc ggctttgtgg aatgggatat tcggagaaat 2924581 ctattatgtc ggagaaacaa tccggcaaat tacgccttat attttatccg gattggctgt 2924641 cgcctttgca ttccgaaccg gactctttaa tatcggcgtc gagggacagc tgctcgtcgg 2924701 ctggacagca gcggtttggg tcggtacggc gtttgacgga ccggcatata ttcacttgcc 2924761 gctcgcattg attacagcgg cagctgcagg aggattatgg gggtttattc ccggcatttt 2924821 gaaagcgcga ttttacgttc atgaagtcat tgtcaccatt atgatgaatt atatcgcgct 2924881 gcacatgacc aattacatca tttcaaacgt cttgacagat catcaggaca agacggggaa 2924941 aattcacgaa tccgcctccc tccgctctcc ttttcttgaa cagatcaccg attactcacg 2925001 gctgcatttg ggaatcatcg ttgcccttct cgcagcagtt atcatgtggt ttatcatcaa 2925061 caaatctaca aaaggatttg agctccgggc ggtcgggttt aaccagcacg cttcccagta 2925121 tgccggcatg agcgtgcgga agaatatcat gacctccatg cttatctccg gcgcttttgc 2925181 aggtcttgcc ggagccatgg agggcctagg gacattcgaa tacgcagcag tgaaaggcgc 2925241 atttaccggc gtaggctttg acggtatcgc tgtcgctctt ctcgggggaa acacagccgt 2925301 aggcgttgta ctggcagcat gcctgcttgg cgggctgaaa atcggcgcat taaatatgcc 2925361 gattgaatca ggcgttccat cagaggtcgt tgatattgtg attgccatta ttattctatt 2925421 tgtggcttca agctatgcga ttcgtttcgt catgggcaaa ttgaagaaaa agggggcgaa 2925481 ctaagtggac attgtgcaga ttttatctat cattgtccct gccacactcg tctatgcggc 2925541 cccgcttatt ttaactgctc tcggcggcgt gttttccgag agatcaggtg tggtgaatat 2925601 cggcctagaa ggcctcatga ttatcggggc gttcaccagc gtgttattta atttattttt 2925661 tggtcaggaa ttaggtgccg ccgcaccttg gctttcgctc cttgccgcca tggcagcagg 2925721 cgccctgttt tcactgattc acgcggcagc ggcgatttcg tttcgcgccg accagacagt 2925781 cagcggtgtc gccattaaca tgctggcgct tggggcaact ttatttatcg tcaaactgat 2925841 ctacggcaaa gcgcagacag acaaaattcc agagcctttt tataagacga aaatccccgg 2925901 tttgggcgat attcccgtct tgggaaagat cttcttttcg gatgtctatt atacgtctat 2925961 tcttgcaata gcacttgcct ttatttcctg gtttatcttg ttcaaaacgc cgttcggcct 2926021 tcgtatccgt tctgtcggcg agcatccgat ggcggccgat acgatgggaa tcaacgtata 2926081 taaaatgcgc tacatcggcg tgatgatcag cggattgttc ggcggtctcg gcggcggcgt 2926141 atatgcctcc acaattgcgc ttgatttcac gcactctacc atctccgggc aaggttttat 2926201 cgccctggca gcgcttgtat tcggaaaatg gcatccgatc ggagcactgg gggccgccct 2926261 gtttttcgga ttcgcccaaa gcttaagcat cattggatcg ctgctccctc tttttaaaga 2926321 cataccaaat gtgtatatgc tgatggctcc ttatatctta acgattctcg ctttaaccgg 2926381 ctttatcggg cgggcagatg cgccaaaagc caatggcgtg ccttatatta aaggaaaaag 2926441 ataaacattc tcccctggga agacgattct cagggatttt tttctaatcc aaaagacccc 2926501 cttaatttaa ttgtttatta gttttttaac ttaaaaaaat atgaagtgtt aacgctttct 2926561 tgtagactgt aacaaacaat acatgggggt gtatgacatg ggagcaattc caaaaacggg 2926621 gacaatttca cctgagcaaa aagactcaca ggagaaaaac ctgtttcaaa aaatttggtc 2926681 ttgggaaatc ggtgtgattc ctttgccatt atacacagta ttagctgtta ttattattct 2926741 tgcagcatat tacaatgagc tgccggcaaa tatgcttggc gggtttgcca tcattatgat 2926801 tcttggtgtg tttctcggag acataggcca acgcataccg atattgaagg atattggcgg 2926861 ccctgctatt ttatctttgt ttgttccttc atttttagtc ttttacaatg tactgaattc 2926921 aacatcttta gacgctgtaa ccaacttgat gaaaacgtct aacttccttt atttctatat 2926981 cgcttgcctt gttgtgggaa gtatcctcgg tatgaacaga attgttttaa tacaggggtt 2927041 tatcagaatg ttcgttccac tggttgcagg aacgatcgcg gccgttgcag ccggcatcct 2927101 tgtcggattt atttttggct atagtgccta tgattccttt ttctttgttg ttgtcccgat 2927161 tattgccggg ggaataggtg aagggatttt gccgctttca atcgcctatt cacaaatact 2927221 gggctcatcc gccgatgtat ttgtgtctca gctggtgcca gccgcaatta taggaaacgt 2927281 ttttgctatc atatgtgcag ccttaatgaa aaagcttggc gacaagcgtc cagatctaaa 2927341 tgggaacgga cgtctcgtaa aatctaaaaa agcaaatgag attttcaatc aaaaagaagc 2927401 cgaagcaaaa attgatttta aactaatggg agcaggagtt ctgctcgcgt gtacattctt 2927461 tatttttggc gggttattgg agaaattcat cttcatcccg ggcgcgatct taatgattat 2927521 ttcagctgcg gctgtcaagt atgcaaatat tcttccgaaa aaaatggaag aaggcgctta 2927581 ccagctttat aagtttattt cttcaagctt tacatggccg ctgatggtcg gtctcggcat 2927641 cctctttatt ccgttggatg acgtagcgtc tgtgatttct ataccgtttg tcatcatctg 2927701 tatttcagtt gttatcgcga tgattggttc tggatatttc gtaggcaagc tgatgaacat 2927761 gtatccggtt gaatccgcaa tcgttacctg ctgccacagc ggtctcggcg gaacgggtga 2927821 tgttgccatt ttatcggcat caggaagaat gggccttatg ccgtttgccc aaatttcaac 2927881 ccgtctcggc ggtgcaggca cagttatttg cgcgacagtg ctgcttcgtt ttttcacttc 2927941 ataaacagaa agagttccgt tttatgcgga actctttttt tatttattca caatccgaat 2928001 atactctcgg ggaccaaacg gcagatcctt tgattccgtc tcactcattc tggctgacag 2928061 gtggtgctcc agtaaataca gctcccactc atcacaagcc gccacaccgc tgcgcccgtc 2928121 atattgattc aacatgaatg cccctgcaaa tactgagcag aataaacctg agcacatcac 2928181 gacttttgtt ttcacatgac cagctccttt ccttcagctt gatcaggatt gattttaaat 2928241 atacaaataa cctctttttt gttagactta ttttgaggtc aaaagaactc ataaaaatcc 2928301 attacagcag ttcgaagcgt ggcagcttgc agaaaagtgc gatataattt ggactaggtc 2928361 gtttgaccgt atattttata catagcgcat ttttcaattg agaacgagaa aaggaggtct 2928421 tatctttgca gctcttacat cttgctattt tatcgccttt tttatttgct tttatcattc 2928481 ccttcttggc aaaatacgca aaaagagtgc atacgggctg gtttgtgttg atcctgcccg 2928541 tcttgctgtt tatatacttt ctcccaatga tcaggatgac gcaatctgga gaaacacttc 2928601 gatcggtatt agagtggatt ccgtcactcg gcattaactt taccgtttat atagacggcc 2928661 tcgggttatt attcgcttta ctgatcacag gcattggctc tttggtcact ctttacagca 2928721 ttttttattt atcgaaagaa aaagaacagc ttgggccctt ttatgtctac ttattgatgt 2928781 tcatgggcgc catgctcggc gtcgttctag tagacaatgt catggttctc tacatgttct 2928841 gggagcttac aagcctttca tcctttttgc tgatcggcta ttggtataag cgggaaaagt 2928901 cgcgctatgg cgcagccaaa tcacttttga ttacggtcag cggcgggctg tgcatgctcg 2928961 gcggatttat tctcctttat ttgataacgg attccttcag tattcgagag atggttcacc 2929021 aggttcaatt aattgccggc cacgaattgt ttatcccggc tatgattctc attttattag 2929081 gggcttttac gaaatcggcg caatttcctt tttacatctg gctccctgac gcgatggaag 2929141 ctccgacgcc tgtcagcgct tatctccatt cagctactat ggtaaaagcc ggcatttatg 2929201 tgattgcgag attcagtcct attttcgcct tttcagctca gtggttttgg atcgtgtccc 2929261 tcgtcggcct ctttacgatg gtttggggtt cattccatgc cgtgaaacaa actgatttaa 2929321 aatcgatttt ggcgttttca accgtcagcc agctcggcat gatcatctcc atgctcggag 2929381 tcagtgctgc ggcccttcat tacggacata cagaatatta tacagttgcc gctatggctg 2929441 ccattttcca tttgatcaac cacgcaacct ttaaaggaag cttgtttatg gcagtcggga 2929501 ttatcgatca cgaaacaggc acacgggata tccggaagct aggcggcctg atggcgatta 2929561 tgccgattac ttttaccatt tccttaatcg ggacattttc aatggccggc ctaccgccgt 2929621 ttaacggatt tttgagtaaa gaaatgtttt tcacaagcat gcttcgcgtg acacattttg 2929681 acctgttcaa cgtgcagaca tggggcgttc tgttccctct tttcgcctgg atcggaagtg 2929741 tatttacgtt tatctacagc atgaaattgc tgtttaaaac attcagagga aattaccagc 2929801 ctgaacagct tgaaaaacag gctcacgaag cgcctgtcgg tatgctcgtt ccaccggtca 2929861 ttcttgtcgc tttggctgtc agtctcttct ttttcccgaa tatattgtcg tacagcctga 2929921 tagagcctgc gatgaactca atctatccga cactgcttga cggccatgag aaattccacg 2929981 ttcacatttc acagtggcat ggggttacaa cggaattgct catgactgcg ggtattgttg 2930041 tgatcggaac aattggttat ttgtcgctga ataagtggaa aggaatctat aaactgtttc 2930101 cttcgaaact cacactcaac cggttatacg ataagctttt gactatgatg gagaaaggct 2930161 cttaccgggt cacaaaacaa tatatgaccg ggtttttaag agattatttg ctgtatatct 2930221 tcgctggttt catcattctg ataggcggag cttttgccat taaaggcgga ttttcattta 2930281 aaacggaagg catggctaaa atcggtgtat acgaaatcat tttgacgctt gtcatgatca 2930341 gcgccacagt ggcgactgtt tttgctaggt caagactgac ggcgatcatt gcactcggtg 2930401 ttgtcggtta tacgcttgca ttgttttttg tcattttcag agcgccggac ttggcattga 2930461 ctcagctcgt cattgaaacg atttctgtgg cactgtttct gctttgcttc taccatttgc 2930521 cgaaactgag gctgaaaaca aaaacgagaa cgttccggat gacgaatttt atcatttctt 2930581 taggcgtcgg tgttatcgtt acactgctcg gcatcgcatc ctcaagccag cggacaaaag 2930641 acagcattgc gtccttcttt gtcaaacaca gccacgatct cggcggaggg gataatgtcg 2930701 tcaatgtcat tctcgttgat ttcaggggat ttgatacaat gtttgaaatt acggtattaa 2930761 cgatagccgc tctcggcatt tacagcatga ttaaaacaaa agtaaaagag gaggggaaaa 2930821 gcggtgaatg aacaaaaaac aaatgacttg attcttcaaa ccgcgacaaa gcttgtatcc 2930881 tttatcattt tgcttttctc tttctattta tttttatcag ggcataacgc gcccggagga 2930941 ggctttgtcg gcggactgat cacgtcctct tccatcgttc tcttgctctt ggcatatgat 2931001 ttaaaaaccg tgcgttccct tttgcctgtc aatttcattt atgtcgcggg agccggcctt 2931061 ctgctcgctg tattaacagg cgttggctcc tttgtcttcg gggctccttt tttaacccac 2931121 acattcggat actttcagct gccgatcctt gggaaaacgg agctcgccac agcgacgata 2931181 tttgatttag gcgtttatct tgttgtcgta ggcataacga tgaccattat tcaaacgatt 2931241 ggagaggaag aataatggaa atcttaatgg ctgtattagc cggtattatt tttatggctg 2931301 ctacgtattt gctgctgtct aaaagcctgc ttcgcgtcat tatcggaaca gcactgttaa 2931361 gccatggcgt tcatttaatg cttttgacta tgggaggatt aaagaaaggc gccgctccga 2931421 ttttgagcga gcatgccaaa tcatttgtcg atccgcttcc gcaagccctg attttgaccg 2931481 caattgtcat ttcttttggc gttacgtcat tcatcctcgt catggccttt cgcgcttatc 2931541 aggaattgaa atcggacgat atggatcaaa tgaggggaaa tgatcaacat gaataatttt 2931601 gttattttgc caatcctgat cccgcttttg tcggctattc ttctgatttt catgacgaag 2931661 aatcttatgc tcatgagaat cttcagcacg gcggcatcgg ccatcgggat tgtgattagc 2931721 ggcatacttg tacagactgt cttcacaaaa ggcatccaga cactcagcct aggcggatgg 2931781 aaagcgccgt acggcattgt gcttgccgca gaccaattcg ccagccttct cgttctcaca 2931841 acagcgatca tcggtttatt ggttgggctt tattccttcc gttctgtcgg tgaaaaacgg 2931901 gagcgctcct tttactactc cggcgttcag ttcttgcttg ccggcgtcag cggagcgttt 2931961 ttaacaggcg atttatttaa tatgtacgta ttttttgagc ttctgcttat tgcttcctat 2932021 atgctgattg tattaggcgg cacaaaaatt cagctgcggg aatcccttaa atatattgtg 2932081 tttaatattg tatcgtctgc cctgtttgtc ataggggtcg gctttttata cgctgtaacc 2932141 ggtacgttaa acatggcgga tcttagcgtg aaaatcagcg aatcaggaca aaccgggctg 2932201 atcactgtga ttggtgtcct gctgcttttg gtatttggca tgaagggcgg aatcttcccc 2932261 ctctactttt ggcttccagg ctcttattac gcgccaccgg cggcaatctc cgcgttgttc 2932321 ggcgctttgc tgacaaaagt cgggttatat gcgattacga gggttttcac attgattttt 2932381 attcacgata cagcctttac ccatcagttg atgatttggc tggcggcgct gactgtgatt 2932441 tttggtgtga tcggttcact cgcttattcg aatgtcatga aaattgtgat ctataacatt 2932501 attaccgctg tcggcgtgat tttgttcggt gtggcagtac acacccccgc atccattcag 2932561 ggcgcgatct actatctgat tcacgatatg ctgattaagg gcgctttgtt catgctggca 2932621 ggtacgctga tcgcattgac tggaaccgcg agcctgcata aaatgggcgg gctgatcaaa 2932681 cgctatcctg ttcttggatg gatgtttttc atttccgcta tttctcttgc aggcattccg 2932741 ccactgagcg gatttgtcgg caaatttaaa attgcagagg gcggcttcgc agaaggtgaa 2932801 tttacgatat ccatgctgat tctgctttcg agtctgcttg tactgtactc tgtgctgagg 2932861 atctttatac atgcgttttg gggcgaagaa aaagaaacgc caaaaccaaa tcatcgaaca 2932921 gctaaaggac ttctttatcc ggcagctatt tttctcttgc tgtcccttct cttcggattg 2932981 ggtacagaat gggtgtcgcc ttacgttgat caagcggccg agacgctgct gaatccggaa 2933041 aaatatatcg aagctgttct gaaggagtag atcgcatggc atttcaaatt ttattaaatg 2933101 tgtttctcgc tttttgctgg atgttcttaa gcaacagtcc aagcgccgca ggattcatta 2933161 caggctatat tctgggaatg ctctctctct ttttcttccg gcgctttttc actcgccagt 2933221 tttatctatg gaaattgatt tctattatca agctctgttt catttttata aaggaactgt 2933281 accttgccaa tgtcagtgtg atgaaatcag tcttatctcc aaaactgaat atcagaccgg 2933341 gtatttttgc ttttaaaact gaactgacga aggactggga aatcaccatg ctttctctgc 2933401 tcattacatt aacgccggga accttggtga tggatatttc agatgacaga acaatacttt 2933461 atattcatgc aatggatatc gaggatgcgg aaaaagcgat ttttgacatt cgggagtcat 2933521 ttgaaaaagc catacaggag gtgagccggt gatgtttacg ctgatcctgc aaatcgcgct 2933581 cggcattatg gcagtgtcta cctttttgta tgtcattcgt gtcattaaag gtccgactgt 2933641 gcctgaccgg gtcgtggctc tggatgcaat cggcatcaat ctgatcgcaa tcacggcgct 2933701 tgtctccatt ttgctgaaaa caagtgcgtt tttggatatt attttgttgc tggggatttt 2933761 atcgtttatc ggaacgatcg cattttccaa gttcctggag aaaggagaga ttatcgaaaa 2933821 tgatcgaaac cgctaaggtc gttgtggctg tattcatttt gctgggtgct cttatatgcc 2933881 tcattgcttc atttggcgta cttcgccttc ccgatgtgtt tacacgcgct catgctgctt 2933941 ctaaaggctc aacattaggt gtcaatatga ttctgctcgg tgtcttcttc tatttgtggt 2934001 ttgtgacggg ggagctctcc gctaaaatcc tgcttgggat tctctttatc tttattacgt 2934061 cgcctatcgg cgggcacttg atctgccgtg ctgcgtataa ctccggcgtc aagcttgatg 2934121 agagaagtgt gcaagatgac tataacggaa tcagaaactt tgtgattaaa cgaaaagagg 2934181 attcttattt ataaaaataa gcagccggac aggcagagtt ccggctgttt ttttatttct 2934241 tgatgacagc cagcgtgcat ctggatatac agatcagcct ctcttgctcg tcatatatgt 2934301 gaatatgata gacaatcgtc gttctgccta tatgaacggg ctcggctatc gcctttaccg 2934361 ttccttcctt tacagatttt aaatggttgg cgttaatctc caaaccaaca caagcttgcg 2934421 ttgtatgatc aatcaggttc tgtgcacctg cgctcgccgc ggtttccgcc agggccactg 2934481 aagcgcctcc atgcaaatat ccgaacggct gtaccgtccg atgatccacc ggcatgaccg 2934541 caacgcatcg ttccgctgtg ttttcaacaa tctcaatacc aagcgcttca agcaatgtgt 2934601 gcttcatatc catctctaca ccccccaaca tttaaagtac accgtctgat ttcgcaatca 2934661 aaaccgcttc cgtccgtgaa ccgacattca gcttattgaa aatcgatgtc aagctgtatt 2934721 caatggaccg cttgcttaaa tgaagggcat ctgcgatttc ttggtttgta aatccctttt 2934781 caacttcttg aagaatcagg cattctctag gtgtgagcac atcttgttct ttttgagagg 2934841 aaggagccgg ctttgttttt tgctgagtca tcagctgttt aaagtaagca aaatcgacta 2934901 aaatttctcc gttgagtacg tggtatatgt attgggtgat cttttcttta gattccgttt 2934961 tgctgatggc accgtgcaga cccgcacgaa tcgcttcctc gaaataatcc tcgacctcat 2935021 aaccggtata cacgataatt ttacaatgag gattctcttg taaaatctgt ttagaaagct 2935081 ccatcccatt gacctcgccg cctagattca gatccattaa aatgagatca tatgacgaga 2935141 aatcatgctg cttgataaac tgttcgctcg gttcaggact gagacaatca acagacaaat 2935201 tcgaatccgt ttccaaaatt gtcttggtgc cttccatgac agccggatgg tcatcaatca 2935261 ctagtatctt tttcatgttt tcctcccttt tactcactct tttccatttt ataaaaaaga 2935321 cttggcctgt gccaagtcgt ttccgttata aatccattac aattcgattt caatatcagc 2935381 cttaaagccc tttccttcac ttgtttcaat ccgaaggcgc ccatctaaag ccctgactct 2935441 ctccttaatg ccagaaagcc ccatgctcat ggaatgctca gtattttttt cttgatcaaa 2935501 cccaacgcca tcgtcctcat aatgaagaac gattttgttt tgaatactga tgagcataat 2935561 cagcacatcc gtcgcctgag agtgcttgac cgcattagac agaaactctt gaatgatccg 2935621 gtacaaattc agctgcgaat ccagatcaag ggaagccgta aatctcccgg tatttaaacg 2935681 gatatgaaac ggaacccgct cctgctgctg cgccaccagc ttcgacagcg ccttcaccaa 2935741 tccaagatca tacagaagct gcggccgcag ctcatgacac gtctccctcg tcatcgaaat 2935801 cacatcagac atctgctcat tcatctgtac aagcttgtcc tgcacctctt cacggcacgg 2935861 attatcatcc ttcttgaaat cacccaaaaa cagctcacac tggcgtttta aggaaatcaa 2935921 atcctgaaga accgaatcgt ggagatcgcg ggcgagtcct gaacgctgtt tttcttcgat 2935981 tgcaaacatt agctttttca gccagatggg gttggttccc tcttgtttta agtccttcaa 2936041 atgttccatg agctcctcaa tatgcaggac attttccatg gacacacttg tataaaaaga 2936101 cagtgttttc agccacgata tttcatcacg tgttagccgg ggagtgttaa tattagataa 2936161 acaaagcaga acataagaac taccgcctcg ttcaccaact ttcataagaa agccttgatt 2936221 gacttctata attttcccaa tttctgaagt tacgttttca aattcctctt gataaaaatt 2936281 ccagtccggt ccaacttcat gcttatctaa aaatatcact ttgtgatcag gagtaacctc 2936341 aaaggtataa gctttgctta caagcaaaac atccagtata gtatttttca gttctttaaa 2936401 aacttgttga agagaagtta cacccctcat tagctgagta tatttaaaaa tactgtcctg 2936461 atagttgaat ttttcggaga aacgttttaa ccgaaattta aaatccatga cctctttaaa 2936521 ataaaagaca gcgaacatga caacgaaaaa aaatacagtt tgacgcacag ggttcatctg 2936581 gatgtccatt acatcaaaca gaactaatgc accaactatt agaagagttg gtatcatggc 2936641 aagtagagca tagtatctca ttcttcctaa gataaactct atatcaaaca tcttattggc 2936701 tacaaattgg tatactaacc cgaacggaat tagtactagt aatgacgccg aagctaatgc 2936761 cgggaaaata taattacctg taaatattat tggaagaaca aaaaatatca aaaaaggcgc 2936821 aaatgaaaga gtgtttgtta aaattagtaa tttaagaata aacgaatgct cagcatattt 2936881 atatttatta agatgtaagt atatcgctga aaaagaaaat agagtcaaag ttgcaaaaga 2936941 aaccaaatta agagttgcta aaaaatcaat atctacttgt aaatagtctt gaaaaaactc 2937001 aataccaaga ttaaatattg gtatgatata aagaaaagaa attctattca aaaaagtttt 2937061 acctatttct ccaaggtatc tttgtataaa ttgaagataa agaataggag aagatataaa 2937121 agtaaacaag ttaatatacc gattgattat atgtcctcta aatggtccgc ctgcacttat 2937181 atatgctatc gaaatgtcta ataacaatag aataagaata taggcagcaa atgatctcct 2937241 ttttttattt actttaagta tataaaaaat acatattatg cttaaaaaat aaaaaaacaa 2937301 aggaagtacg aacagaaaaa aactataagg tctatttaga gtaactaaat caaaatcttt 2937361 gagatgaatc ttttttccac ttctcaaaat atccagactg ttaatatgac tcaaatatcc 2937421 ccatttcaaa tgtttgtctg aaggtttttc tttattaatt tttaatatga tgtctccctg 2937481 tctcagacca acaaattgtc catatgaaga ttccgatatt tcttctatca taaattgact 2937541 tttatcattt ttatgaatct tagtcccaat aataattcca ttcatactga tataagttgt 2937601 atagcttata taaaggatac tcaaaacaat tacagctatt gtgaattttt ttattaagtt 2937661 cttcaatatt aatccaccta ttaatcaccc cattgacggg ttattggatc agccagataa 2937721 taatcattat aagctttaat tattgtttca gtttcttgca catcaaaacc tataaggcag 2937781 gcttctttat ttttcaattt ttttaaagcc tcaggataat ttaaaaagta gttaattagg 2937841 tcttgcatct tgtatccccc tttgtataac ttaataagca ttcctttatt agctcttttt 2937901 tttctttatc taaatttaat tgttctatag cagaaataca tttctgttta tatatttcca 2937961 ataataccga aatgtattga gtaactcccg ctttaattaa tttttcttgg aatttctctt 2938021 tatcaagtaa cgatttataa tataagtctt tatgtgaaat taagtataat aaatcttccg 2938081 aagcatcatt aaaaaggcgc ttaagatata agtaaatcag tgtatgtttg tttttttcaa 2938141 tatcactgcg atttccggat aaaagaacat aataatctcc agaaatttga gctataatcc 2938201 ctttatagta ggaatatctt tcaactgttt cattatattc tcctgtagcc aataaaacac 2938261 ctgctacatt tgctagtgca atcagacttc cacattttaa tctaattact tctaaacttt 2938321 catcttctgt tttagattta ttagtgatat cgtcatgttg accttgcatg gcctcgttta 2938381 cgtattttaa aacatattta aaaattagag gattgttatt taatgaataa atactcgtta 2938441 atcctactgt atacaaggaa agtgctgcat ttaacgactc cgagcgatta attttcatcc 2938501 ataatgcatg gtgattatct tcatcttcaa gatcatccat aatatctgat gaaagaataa 2938561 gaatttctat tcccgcgcca agccttgttg caacatctaa attctcccct ccaaaaacaa 2938621 cataatgtaa gattgtggat tcagcaaagg agaatgtttc tttagaatca ataaatgagt 2938681 aaagaagttg tgacaaatcc tcgttaaata tgttttgctc cacaatctcc ttcattttct 2938741 ccttgatccg gacagaatct aaacatatct gctcaataac gacttccccc ctcccattcc 2938801 attttactaa atgggacatt taaaggacag caggtttttc gttttttaac aatcatataa 2938861 tactttatcc atttattgta tcggtagaac gaaaaaaaag acttgtttcc aagtcttttt 2938921 cacgaaattt tcattgcata attgtattta tcgagttgat caatgctttt gttaatgttt 2938981 cgtaatgaat ctgtcgtttc tttaatatca agttcgagtc ggaataacaa ttgttttact 2939041 tcttcaagtt tcttttccat cgtttccaca ctcctttttt tgaaagatca atgaattgtg 2939101 tatggtgaac gagtcctagg tatttgatct gttactaata gtgtgtctgc tttcggctca 2939161 tttttcaccg aaaagtatgc aaaaaagtcc tgcgtgacac cgcaaatctc aataggtcct 2939221 tatactcaaa ggaatcacaa caagaacggg actatctttc tatgcgaaag agcgtttata 2939281 tgtgctgaaa ttgagaaaga ttcttaatct ccttgatttt aacgggtttc gcattttcac 2939341 taagcaagac tatagtcctt cataccgtat tttcaaaatt gaatatgcga ttcttggcgt 2939401 ttcctgaccg acaaacaccg aaaaagaccg caacgctaaa gttgtggcct tttcgctttg 2939461 tcatattcgg caattaggga tctatacata tagaaacatc cttttttgcg aggtgctccc 2939521 atgagatatc gttatccctg gttttacgtg tatccgtatg aggtacgccg tccgcccgct 2939581 cctgccaaca atattgatac ctttatccgt tcagcgaagc aggccgcagg gatatttgcg 2939641 gatgcccagc tcgttctcag ccgcattgcg ggctcgcggg agctttcgcg ccgcattctg 2939701 accgcagccg aacagtctga taaacaaact ataaggcgcc tgatcaaaca aatgggcgtc 2939761 cggcatgaag tggatacggt ctttaatccc gacggcatct atatcagcct tatcggaacg 2939821 caaagccgaa tgattcttgc tttgcggtgg tcagaggacc gcaatcattt tgcgtccata 2939881 agattatgac accattccag agcctctaaa taacattcat acgcttcttc tttgtccagt 2939941 tgattgccta attctgagca agtgtcccag ttgttgcttt caattaattt cacaagctca 2940001 agcatttggt agtagtcgtt ttgatggcct aataatgctt gcccgacttc atcttttaaa 2940061 ggcaattctt gaacaatttc ctctatttct ctatgcagga gggtgtctat gagagaaaac 2940121 attccgatca gcatataaga agcaggctgc ggccgggatg tctttctcgc cagcagttcg 2940181 caaagctttg ctcttatcag agaaatctta atgatttcgt gcttgctgga atgccctttc 2940241 ctgcttaaat ccttaaagga aagaatatat atccaccgtt tgatttcatt aaatcccagc 2940301 agcataatgg cctgttgaat gctttcaatt ttctggctca aacggctgtg ggatgagttt 2940361 aaaaatttta aaatttgata ggacagtgat aaatcccgct ctatgtactc tgtcacacgc 2940421 tttatgttag gctgctcttt actcagttcg ttaagcagtt catagtaaga atagaaatga 2940481 gtcgataggt catgcccgct gatgatgcgc ggctcgctga aaaagtagcc ttggaataat 2940541 tgaaagccgt cttggaccgc ctgtttatat tcttttcggg tctctacttt ttccgctaaa 2940601 aaaatcaggc cgcggcagcc gtaggtttgc aaaattgttc tgcgttccat tcgtgttgtt 2940661 ttgagaaaat caattttcaa tatatcaata tagctcatga gtttttccag taagtcctca 2940721 tcttgcggat ttattgcata aaaatcatca agcgccagca tataccccat ttttttcaat 2940781 tctttgcatc tagaaatgag ggccggcgtg atcggtatat cttcaaggat ttcaatgaca 2940841 agctgtttcg gattgaagga ggtgggaaga ttcgaaaaca tcaggctttc cgtaaaatta 2940901 acaaaacagc gtttcccttc cgtcagcttc tcaattccga tgtttaaaaa gctgttgatc 2940961 accaaatctg ttgttgcctg atcgccgtct ttagcgctat acacgttctc ttcgctttct 2941021 ctatacagca gttcataagc aacaacctgt tcttttctat taaaaatagg ctgtcttgca 2941081 acaaacaccc tcattgattt atccccctta caatacgcgc ggctttcacc cctaagtata 2941141 tcaaataatt tgacgaaaat tgtctaaaca tgaaaaataa tatatacata aagaaaactg 2941201 gcccttcgcg aatgaaaggc cagtttttct ttattcttcc tcaagctctt cttcaattct 2941261 gcttttcact tcgtggatcc gctgcatttt attgctccag cagtcctcgc ttaaatcaac 2941321 cgggtattcc tccggcttgc tgattctctt atattcctcc caaagcaggc tgaggttatc 2941381 ctgcacatac tgctgtatgt ctgaaatctc agggttttgg tagcaaagaa tacccttctc 2941441 aaaaatcagt tcatgaagat ccttcgcata aaaattcgtg acaaatttgc tgatgaatgt 2941501 atgaaccggg tggaacattc tgagccgctt ctgatcattc acctgctcat cataaagcgc 2941561 aatatagtcg ccttcagaat gatggttgga ctgattaata atgcggtaga ctttctttct 2941621 gcccggtgtc gtcacttttt caggattgga cgaaattttg atcgtgtcga ccattttccc 2941681 gtcttcttca atggcaacga gtttataaac tgcgccgaga gccggctggt cataggcagt 2941741 gatcagcttc gtaccgacac cccagacatc aatgcgcgct ccctgagcct ttaaattcat 2941801 aatggtgtgc tcatccaaat cgcttgaagc aatcaccttc gcatctgtaa atcctgcttc 2941861 atcaagcatt ttccgggctt tttttgacag gtacgccaaa tcgccgctgt ccagacggat 2941921 gccaatgaaa ttaatgcggt cgccgaattc cttggcaacc ctaatcgcgt tcggcatgcc 2941981 tgaacgaagc gtgtcatacg tgtcaactaa gaagacgcaa tccttatgtg tttccgcgta 2942041 ttttttgaaa gctgtatatt catcgcggta agcctgcaca agcgcatgcg catgtgtgcc 2942101 ggaaaccggg atattaaagc gctttccggc tcttacattg cttgtcgcgc taaagccgcc 2942161 gattaaggct gctctcgctc cccacatggc cgcatccatt tcgtgcgccc gtcttgttcc 2942221 gaattcaagc gcaacttcat caccgatgac gcctttaatc cgggcagcct ttgttgcgat 2942281 taatgtttga tagttcacaa tgttgagcaa agctgtttca atcagctgcg cttctaccag 2942341 gggtgcctcc accctcataa tcggctcatt gttaaaaacg agttctcctt ctttcatgga 2942401 gtaaagtgaa cctgtaaaag ataagccgcg caaatattca ataaaatctt catgataccc 2942461 gagttcatcc tgtaaataac tcaaatcgct atccgtaaac ttgaaatttt ccaagtattc 2942521 aatggctttt tccaagcccg caaatacggc atagccattt tcaaacggaa gccttctgaa 2942581 aaacagctca aaaatcgctt tcttttcatg aatgccgtct ctccagtacg tttccgccat 2942641 attgatctga taaaggtctg tatgtaatga caggctgtca tctttaaatc cgtactctaa 2942701 cactgttttt ccccttcctt actctgccac ttgcgctccg atgctgtttg caaaatggga 2942761 aagagcccat gcgtgcccct cctgattaaa gctggcaaca gcttgtttat gcacaacaat 2942821 ccgaaaacct ttgttgtatg cgtcaacagc tgtatgcaac acacaaatat ctgtgcagac 2942881 accggcaaga tgcagttcgc caatctgccg ctctctgagt ttgagctcta aatcagttcc 2942941 cgcaaaagca gaatatctcg ttttttccat gtagtaaaca ttaggttcat gttcatgttt 2943001 ctgatataga ggcaaaagct ttccgtacag atcttttcct tccgtgcctt ttatattatg 2943061 cggaggaaaa agacgggttt cagggtgata ttgatcccct tcatcatgag aatctactgc 2943121 taatacgacg taatcaccgt ttgtgatgaa ttctttagtt aaattgacga tcgcctcttc 2943181 aatcattctg ccgggctccc cgcaggtcaa ttttccgtca ctcgccacaa aatcattcgt 2943241 ataatcaata caaataagtg cttttttcat agccggcctc cccgccatca gtatgagaac 2943301 attatatctt atctccagtt gtaagtgaat tgccatgaac aaaaagacaa acggtccgtt 2943361 tgtctcttac gatttcagta ctgaccgatt ataaatgtcg tcctgaatat atatcaattc 2943421 acgattcaca gcgatatcag ccgcaatgac gatgcctaag ggcgtatgaa actggagatc 2943481 agatacaatc ttgaaaggca ctccgtaccg gctcgccatt tggatataag aagagtaaga 2943541 ctgatactga agctctccat taatcaaaag ggtgacgtta tggctgtttt tcagctcgtg 2943601 ctctgcctct ttatacggtt tgcttctaag cacctgtcct ttcgtcagtg ccaaaacgac 2943661 tctttctctt aaagagccta aaaacaaatg gcgctcgtca ggctttgtct ccaaaggccc 2943721 atacattcct tgctgcaaat agagatccat tttatcttca ctcaaaagcc tgtcctcccg 2943781 tcttgtttgt cttcattatc acctgatcag gcaggagcta aactttcaag cgccgtttac 2943841 atttctgtta cccaatgaat gatttttttg gccagctcac cagcaggggt ttcctctgta 2943901 tgccggcgca acgacgcttc cagccgttca ggcagagttg ctttatcttc ttcataggaa 2943961 atgatcgtgc tccactccag ctgcggtacc gctacaagcg tgcgcagttc ttttctgttt 2944021 tcatgcagat acacgtccgt gatcattccg gtttgcgtat tgatatttgc ttttctgatt 2944081 ttcataacat gacctctcta ttcaaagact acccatatta tacaataaaa aagcaacagc 2944141 ctcttgtgaa aaggctgtta cccgttaaac gaaactgttt catcagtgat atcggcatct 2944201 ttgaagagag ttttactcgt ttggttgtta atcttcacaa aatcaccaag ctgaaatgtg 2944261 cctgaccccg cccctgaatg agcgacgctt ttgggcgaaa tcgcaaatac gtctccaaag 2944321 cttgccgcgg cattatccgt aactgacatg atataaatcg gccccacaat tgcaggcatt 2944381 tccccacctc cgcattgatt tacagcatca tatgcaagga gccgataatg gtgcccgcct 2944441 attcagctgg ctttgcgttt tcctcgagtc gtgaccgctg gcgcagcttg atcaagcgga 2944501 caatattcag gaagaacgcc ttcactaccg cataaaccgg caccgctaaa atcatgccga 2944561 gaattccgcc gaagcttccc gctccgatta atagcaaaat aatcgtaagc ggatgggtat 2944621 tcagccgctt tccgatcaca agaggagaca gcaggtttcc gtccagctgc tgaacgatga 2944681 cgaccacaat aatcgcaaac agcgctttgg ccggcgagtc cataaaaccg acaatgacag 2944741 ccggcgcggc accgagaaaa ggcccgacat agggaatgat attggtaatc gccatgacaa 2944801 tcccaagaat cagggcatac ggcagtccgg caattaaata gccgataaaa cacgctgttc 2944861 cgacaaaaag acagattaac agctgcccct ggaaatatgc cgcaagcgta tcggataaat 2944921 ctttaaaaat ctttaagcct tctgtccgat aagaagccgg tagaattttt actgccaaat 2944981 gcggaaagcg gtgtccgtct ttcagcatgt aaaaaaggat aaatggaaca gtaataataa 2945041 caagcgtgat gtttgtcacg acaccaaaca ccgcagataa actggacgtg atattttgcg 2945101 gcaggttttg gagaaaactt gtcaatgact gttcaatttt tgatatcgat acataatcct 2945161 ggttcatcat ccaggtaaac cattgagaat gggacaaatc ctttgtcagc gcctgaatct 2945221 gttttatata atcaggaagg ttgttaaaca gccctgtcac ctgtgcggtg atgataggtc 2945281 cgactgacgc tgaaataaag gcaagcaaac cgataaacag taaatagatc aatagaatgg 2945341 ataatgtccg cggaattttt ttctcaagca ggcggacgac cggattaaat atgaaataca 2945401 aaattcccgc aattagcatc gggaaaaaca atgtcgagat aaaaacaata aacggctgaa 2945461 atacaaatga aacttttgtt gctacaaaaa taatcagcaa aacaaataaa atctgcaatg 2945521 tccaaaaatg gacttttgat ttcaacaagc tttgttcctc ctagtttttc tttgtctgtc 2945581 agataaaaga acttataccc catcattgta acaaaaatga actcatatca gaactcttaa 2945641 tataatgaaa ggagtgttgg tgatgaaggc cgtgacatac gatacagatt cagaactggc 2945701 ttatatctat gttcttcctc cgaaaaagaa caggaatgta cggactgagg agctcagagt 2945761 caatgattgt ctcctgctgg atatcagcca agatggcaaa atcgccggat tcgaatgttt 2945821 tggtgaggca gcacacctct gtgccccatt tgccgggaaa tcccggctgt atgtaaaaga 2945881 ttcagacggt tatcattttc gggtctgcca gcatgcttca gtccgttcct gctatacggt 2945941 gtaccgtgtc actttctgtt tttcagatgg tgactatcag gaatttgccg gctttgacct 2946001 tgatggaaca atgtatcata gtgcgttttt acagcgctta actgaaaaat aggacgtcct 2946061 gttgtacgcc tatttttcat gcgcaagcac tgttagaccc gctcactgta atctggggtg 2946121 acggaaatca tgtgctggat tctgatcaaa caaacagaat ttcgggctcc ttcaattgtg 2946181 atatggtcag gttttacatc gatcagtctg cctctgaccg tatctcgtac tgtctgtata 2946241 acgaaccttg agccgatgag ctttttaatg gtctgataga cataaggatc gactaaagag 2946301 accagttgcg gactaccttg gttgaccata cttttatccc ctttgtgtgt tttatctcag 2946361 cttatgccgc gcttatggat aatgacacag gcttacctga taaaacaaag gggtgcggag 2946421 attttaggag aatacgtttg gaggcgggtg taaaggaagt atcgatgaag cggagacagc 2946481 gaagaaagct ggcgctgttc cgtacttata caggctttat cacggatgcc tgggcttggt 2946541 cgattaattg gtccagcttt tctatttttt ttcgtgcggt tgaaggatca atttggcggt 2946601 aatgatggtg gccgcccggc tcttcatcca gttcgtccgc ttttttgaca atctgctgca 2946661 gtgtgttttt atctaattcg ccttcaggca aataggaatc tgtatgaagc aaaatggcta 2946721 gtgcaatctc ttttgctgct ttcggttcct cgccaagccg aatcagaagt ttatgcgccc 2946781 gttccgcccc tttaatggca tgaatgtcat ttcttttgta tttctcataa tcccactttc 2946841 cgtctgtata ccattcataa tggccaatgt catgaagcag tgccgctttt gctgctaaat 2946901 caggattaat gtcagccttc acagacagcc tgtatgcatg ataagcgcag gcaatcgcat 2946961 gtgccacgcc ggaacgctga agatattttt gtgcaattgg atgggtgaaa acatccatta 2947021 atgtaacctt tctcatggaa acccctcctt tagatatttt tagaatccta acataatttg 2947081 cagagaaact caattcttat gtcacatcat tttgatcttc ttatcatcat tgttataccc 2947141 taaaagcaac gtttcagtca gtatatgcgg ctgttcaata aaatgcgctg gctgcagcct 2947201 tttgtataaa aaaaagagca gaaaatatct gctctacaaa aactctttaa tatcataaat 2947261 gcggccgttt tccgtccctt tttctagtaa agaaagcagc gtgccggcaa taaagtccgg 2947321 actgcgaagg cttcctgttt catttaattt ccggaatcgt tcaatgtggt ggaaatcctt 2947381 tttcgatgaa gaacggatga cggcctgcat ctcagtgtcc atcactccag gtgagaacga 2947441 aatcatgttc accggcagct cttcatcctc ctgttcaaat ccgaatgtcc tcgtaaacat 2947501 gtcgagcccg gcttttgaac tgcaatacgc gctccatccc ttatatggat ttttggcggc 2947561 tcctgaagta atgttgacaa ccgtcttttt gccgctgtat gaagcaaacc gttttgtaaa 2947621 cagctgactc aaaagcacgg gcgcagtcag gttcagctga taatggcgct gaagctcgtc 2947681 aagagacgct tcgccggcac gtttgatcgg cgttaccatt ccggcgttat taataagggt 2947741 aataccagaa taacgatctg aatcgatgga tgagagcaat gtttcaaatt gctgttcagc 2947801 ttcttcgaga ttgatgaggt ctatttgatg ctgcgttagt tttttgtgag agacatctgt 2947861 tttcgttctg gataaggcat ggacttcatg ccccttttct aaagcctgta atgcaatggc 2947921 ttgacccagc ccttttgacg ctccggtgat gatataaagt tccattggaa acctcctttt 2947981 ccgttattat tgtacggcac ctcttttaca caacacaagc acgcggccta cgccttcttg 2948041 ttttcctgcg ctgtgacttt tgggatgagg aacacgatgc ctgcaattcc gagcaggatc 2948101 agtacgacat agatcatcgg cagcagcaat gatgatgttt cttgttcatc ttctgtttcc 2948161 gttgatgatg tctttgtcat tggtttttca gcaaaagtaa ttccaagctg tttcgactgg 2948221 gccgcaatcg tgttggaatc ctcggcattt gttgatgtaa acaaatcttt tatcagctcg 2948281 gcgtccttgt ccttcggttt atcaaaagtg atatcctttt gttcctcagg cagttctgtt 2948341 ttttcttcat agtaggtatc ttcatgcaaa taattcgtat cgatttcgat gtcttttttc 2948401 tcatactggt ttggcgcgac atctgtattt tcttcagttt gggcagccgc tgcagagggt 2948461 atgaaaaggg aaaaggagag catacaaatc atgatcccct tttccatgct gcgatcacgc 2948521 ttcatacgtt tcatcgcttt ctgctgtgtg ttcagccatc aaccggataa tcagcggcag 2948581 agccacggca atcaccgtaa tgatcagcag aactgttatt cccattgtaa acaagtgccc 2948641 agtaccgtac tggatgtcga tatatacttt cgaaaccgga tcttcaaatg taaagttcgg 2948701 catgatcaaa tcaataagcg gtgcgacata gaataggatc attgctgctg aagcaaccca 2948761 gccagggatt gatccgaatc tgaatgccgt ccggatgaag gcagagcttg cgaccagcaa 2948821 tagaatcgta aacaccgacc acttaatcgt ctgatcgtcc ggcagtgaat aaatattcaa 2948881 gccgaacaag ctgatcataa gtccgacaag gatattcaga attccgaata acgctccttt 2948941 gacgagaagc ggtgcgtttt ggtaatacga gctgaaatag ccgattaaca gactgctgat 2949001 caacacaatg acaaggatga caaccggagg taccgtctga attttttctt ccggaacctc 2949061 tccgctgatt ttaagcggat tcgctaagta atcatataca tagccattgt tttgcccgtc 2949121 tactaatgta tttccgagta tgccgtatac gtcatttcgc acgagtttcg tggaggcgac 2949181 atttttcccc cagttgttgt ttaaggtgtc ggctttcgct tgaacatcat taacgctttg 2949241 ctgcatgttg gttgtgtaat caatgatgcc ggactggcga tcagacaatg aacccatcat 2949301 gtctgacatt tgcagcactt cctggccgac cgtatcttgg acactcagtg ccatggtacc 2949361 agacagccca tcgttgctga acgtcgcaga ttcctgtgtt gcgcccgtta caagctgttc 2949421 tgacgctttt gcggcacttt cagagatttt cgtcagttcg tcgagaacac ctgcttgaga 2949481 gtcacggata tagccgctgt agtcgtccgc aaatttggtc atgccgtcga tgaagctgtt 2949541 aatatcctca tctgtttgca tcgtgttgtt tttgagagct tcccagctgg ctgattcttc 2949601 aggtgtgaga gccaggactg attggacgtt gccatcttgc tcttggatga cttcaccttt 2949661 aataatagtc aaagagccta gatccagatt atcatttagc gtagacttat ataaatttaa 2949721 agagttgtaa tacttcatca agttagaaat attatcagtt tcaattctac ttgaaaaaat 2949781 tgaacttagt ttttctttct gatctatata gcctctactc tgcaaagttt gtattatttc 2949841 gtcttccaaa ttgtatatta acctataagc atcattgaca ttattatcaa aatcaaccaa 2949901 cttttttgtt aagtcaccaa tttgatcatt taattttgaa actgttttat ttaactcttt 2949961 aatttcttga tttaactcat caatatgttt ctctagtttg ttgttatgtt cctcttgttt 2950021 ttcttgaagt gcattttcta tttcctctaa ttttatcgct gcttcgttca gacgtttttt 2950081 tgcacctgaa atatcagttt caccgtcagc tccgtcaccc tgtagcccat cactttgatt 2950141 tgagccatcg ttttcatctg cgagttcaat caaagagaaa tctgttttag aggttcctgt 2950201 attctccgtg tttgtatctt gttcaggaac gttttttgaa gattcttgat gtttttgtcc 2950261 cgtttcaatg ttagtttgaa catcattttg tgatccatta tcttgagtac cctcttctga 2950321 tgagccagta tcttcatttg ttggctgatc atcggatgtt ggaatatcat tcgacggttc 2950381 ttcagtatta ggagaatcat cggttgatgg ttcttcagca tcgggtgttg ttggtttttc 2950441 ttgttcaggt tcttttaacc cttcagagat atctttaatt tcagttgcaa catttttgag 2950501 ctcatcccgc tgcttctcta aatccaattt tatatcttca atatcttcct tatctgtgtc 2950561 atctttatta tcagatgtgt cttctccatc ttccttttcg tcgctttcct taggtttaag 2950621 taaactaagg cggttcttcc cgatattctc ttgcaattga tttaaatttt gatatttaat 2950681 agcttcatat tgacttttat atcgagatag aaatgcatta aacatgtcat tctcaatttt 2950741 tttcataccc atttcttgca atggcacttg attttgcctt aacttttcag cattgttcaa 2950801 cgcaaggttt gtcagtccta tttgtgtctt cgcttggccg atcccggttg ccaatccgct 2950861 catgcgttcg ctgaactgat tcgccttttg ctgtgcctgg atggcatcca gacctgtccg 2950921 gatttgctgc tgtgttgaat cctgggctgc caaaagcagc tttttctgat tctcttgata 2950981 ttctttgtac ctttcaactg tatcaatgaa ttctttcagc gtgtttttgg cttcctccgc 2951041 cgtagaagct ttttcttttg tcgtgccttg cgcttcattc attgatttct tcagctcatc 2951101 gattaagtct ttttgctgtt tgatttcacc tgctaaatca ttagagcttg gtttgtaaaa 2951161 gttgtacatg acattctgga attcagattc tttattgacg atcttgtcaa attctcctct 2951221 gatgttgtcc actttttgcg aaacaaaatt ccagtataag gccgacattt ttttgttcat 2951281 tgtcttttgg gcatcctcaa gctcacgctg aactttttct ttgttaaccg cattcaggtt 2951341 atcttgaatg ctgaattcga gcgttgcctt ttgaggatgg tctttgtcat agctcaaaat 2951401 gttttttgag aagtctgagg gaatgtagac aatcgcatcg tatttctttg aagcgagacc 2951461 ggtctcggcc gcgcttcggt ttacgaccgt ccacgaataa tcaggacgtt cacccagaac 2951521 ggccgctact tccttgccga actgggcgga tttgtcctct tcatcagact ttacctcatc 2951581 actcaatacg cctgtgtctt cattcaccac cgcgatttgc cgggtagaat tgactgcttt 2951641 tttcgttggg tcgtctccga taaatcggaa aaacaacacc ggcagcagca aaatgatgat 2951701 gacggcggat attaacttga tcaagctttt tcgttgttct gtcatctagc actctccctt 2951761 tcagcagaac ataaaggaat ttgaactttt tgctccttcc cgttttccac aacatatccg 2951821 aagcccggct gaatctcagg ctcctgtctt tggtacggga gaggaatgac attttgctca 2951881 gactttttca tcagcagaat cgcgtggcgg atttgcttca tctcagtcgt caaggagtca 2951941 tagccttttg agaattcgct gtggtttccg cccgggataa agctgaaccc aagatgagcg 2952001 tatgatttca tgaagttagc gagacgatct tgtattctcg tatcaatcgt ctgctggaat 2952061 ctcgttatcc cgtcaatcat cagcacgact tgtgagaatc gcagattttg tgcgtctcct 2952121 tggcggacgg cttctacata catggcttct cttgttttga aaatgtcttc tgctgtttca 2952181 atccactgct caatatcttc tttcgtttcc aaatatgaaa catctgattc cttcgcataa 2952241 tgagataagc cgcggtcaat cgagtcaaac aggccgatca tttcggtttc atcatcaatc 2952301 agatgttcaa gcatgacttt taggacgttt gttttcccgc gctgagtttg gcctaaaatc 2952361 aggcagtgct tatgcttgcc caaatcaaaa tagactgggc tgactgtttc ttcatgaagc 2952421 ccgatcggta cagataaagg cttgcgttcc agcttgaagc ggatagacaa ttctctcgtc 2952481 gacaagctct caggcagcat cggaatcggt gccggctgct ccattgaagc aaatcgccct 2952541 tgaagtttct gtacgtctga tttcagctcg ttgaacatgc cgatatcatc atcggcgtca 2952601 acaggcagga acatttgcgc gaaataaagc tcttcctttt gaatgatgac gcgtcccgga 2952661 atcggctcaa gattgaattt cggacggccg taaatggaat atccttctga ttgatccatg 2952721 agataatgga caatctttgt tttcaagtta tttaacaatg actggcggac agcattcacc 2952781 cgcgttgctg tcagcataaa gtagataccc aagctttgtc cgtctctgga aagctggaca 2952841 aattccgatt caagctcatg catctcatcc ttgacaatgt caaagttgtc aatggtgata 2952901 aaaatgaatg gaagctcttc ttcgctcagc gcattgtaca ttttgatgtg gctgatttct 2952961 ttttcccgga acaaacgttt acggcggtca atttcttctt tgatgcgaat catgaacttt 2953021 tcaattttcc ttgactggtc catcaggaag taatccgcgg tatgcgggag cttcgctaat 2953081 ggcagcagcg ttccgtttcc gaaatcaaag atatagacat gaagctcttc aggtgtgtat 2953141 acgtccgcaa aactcatcag gaacgttgcg gctgcaatcg attttccgta gcccgaagag 2953201 ccgaagatgc cgatatttcc atcttccatc atcttataag caattggcgc ctgtctttgc 2953261 agatcaggtt catcgacata cgcaaagtgg aaatggtctt tttcgtttga agggaaaaga 2953321 gtgcgcggaa tacgttccgc aagcggcggc agccaagggc ttggcagctt ctcgattccc 2953381 atttcatctt ggatgcgttc aatttcgtca actacagctt cgatttcggt ttgaacgtct 2953441 tttttcgcgt tatcttcggt atcaacctca gaaagcggga tcagacccgt atctgtgacg 2953501 atcgcgattt catcctcggt accgtagact tcctctaagt aaggcgcccc gctccatgca 2953561 gattggaaca gctcatacac ttcattgttt ccgacctgca aatagccgcg gcctgttacg 2953621 gtaatgtttg cggcatcgct gtttttcaaa atttctttac tgtcggtggc atcctggacc 2953681 ttgagcgcta ctttaaagcg cgagttactc cagatctggt cgtcgatgat gccgcctggc 2953741 ttctgtgtcg ccaaaatcaa atgaacgccg aggcttcgtc cgatacgcgc ggcactgaca 2953801 agctccctga taaaatcagg ctcctcgctt ttcagctcgg caaactcatc agaaattaag 2953861 aacaagtgag gcatcgccac ttctgctttc ccttgcttgt atagctttgt atagtcattg 2953921 atgtgattga cttgatactg gtcaaacagg cgctgccttt tttttagctc gcttttaatg 2953981 gaagcaagcg cacgcatact gaagtttttg cttccttcaa tatttgtgat cgtgccgagg 2954041 aggtggggaa tgttacggaa cggctgcgcc attcctccgc ctttatagtc aattagtaag 2954101 aaagccgctt catgcggatg aaaatgcact gcaagtgaca agatgtaggt ctggagaaat 2954161 tcacttttcc ctgatcccgt tgtccccgca agcaagccgt gcggaccgtg tgctttttcg 2954221 tgaaggttca gatacacaat gtcatctttc cctttatagc cgatcggcac tgacagcgac 2954281 ttcgacgatt cacttgtcag ccatctttgc tgaatgccga tttcttttac ttccttcgca 2954341 tgaaaaagct ccaggaacga taccgtttcc ggaatggaat tcgtaatgcc gacctggtgg 2954401 ttcagcgtcc gcagtgtgcg tgaaaaccgt tcgttatcct cacgctgatg atgatcgaga 2954461 cggaacggaa ttcttaccgc ttttttcttt tgtattaaaa tgtcgccttc atgctcatta 2954521 atgtagcgga caagagttgt aatgttttcc gacaagcttt cctttgtttc tgcagcgaca 2954581 attgtcgaga tgcccagatg ctcatgctgc ccttctaaat attcgagaat gacatgctca 2954641 gagatcagct gctgattcgt gatgacaaat acaaaatgcg gtttgaactg cagtttttct 2954701 ttgtcatctt cgagatcacg ctctctgatc aattcgtaaa gtgaagacag gagctgatct 2954761 cgggtttgct cattataaat aaatcctttt gcataaatat ggggcatttg aaattgcgga 2954821 agccacttca tccactccca gtctttatac tcttcttcat gaaaaataaa tacgaaacgc 2954881 aaatcgtgat agctgttaaa gaacgacagc tgtccgatta gctggtgaat ctcatttttc 2954941 acaatttgtg atttaccgac aagccccatc ggaccttctg ccaaatcgac cgtcaccggc 2955001 gcattacgga tatctttata gacgcgttgc atgtgctgcg atttctccat gaggtcatcg 2955061 atatcacgat tcgccaagtc tccgccactc atattgattt catagcttga cggaactgtt 2955121 cccgtcccaa gccgcagctg gagataatcc ttgctttcaa gtgatttttc ccagatccgg 2955181 tcactgattt cacttgttaa gtatttcatt tgttcaaatg aaggaaagtg aaattcaaga 2955241 acctgctttt gcttttcagc aagtgcctga agctctttcc gcttattgtc taagtaaagc 2955301 ttatatacac gctcccgttt ttcctcgcgt tttttccgct ggtttttatc acggaaatat 2955361 tgcactgtcg aggtaatgag agtcatcata aacatcgcca aagaaacgag tataaatatg 2955421 ccgcgcggct ggatgatggc aactacgccc atcacgatca gcatcacaag cggaggcagg 2955481 atgacgagcc acagccctct gttggtttga tcgctctcct gagagggaaa actgaaagaa 2955541 acgcggtcat ccggcagatc gtataccatc cgcggcgttc ttctgtactg cggatatttt 2955601 ttctgcatct ctgtactcgg tttgaccgtt tctgttaacg ctgtttcaaa ctgggcataa 2955661 tgaacaattt ctaaaaggtc ttgttccgtc accctcattt gcgtgaagtt ccagaatatt 2955721 tcatcccccg gcttgagcgg cgtattggcg ttgattttct ctccgttcaa gaagatcgtt 2955781 ccgctttcag ggcggaccga ccagctgccg cctgcacgga gcaaagaaaa cgtgctttgt 2955841 tctgcaaatg caaaatcttg cggattcaga taaatatctg cattcgtttt ttctgaggaa 2955901 catacaattt catcccgatt tcccgtaaaa taaacggatt tctcaggttc actgcccgtc 2955961 aatatcaagc gtatatcctg ctgatccgtt tggagagtaa atgatatatc cgtctcaatc 2956021 gtgccgagac aatcatttcc caggaaaact tcgtattggc cgccggattc ctttctttta 2956081 agagaaatca ctccgctatt aaatggaatg gtgctgatcg taacagaatc cttcacatca 2956141 ggccctatgg tcaccggatg agacgacggg aggttagaca gatttaattt ttgaacgtta 2956201 ttttggtaaa aaacccataa tagactcaaa tggcgaaccc ccttacggcc gaatggcagc 2956261 atgcgatgac ctgcgcttca tgtctcacgt tatttgtcat cttttttctc atctttcttt 2956321 tctgtttctt ttttctcgtc ttctttttcc ttctgttctt cttttttcgc tttttcctcg 2956381 gctgcggctt tttcttctgc cgctttctct tctgcttgtt tttcttcgtc tgtttgtgtc 2956441 tgttcttcgc ttgtatcgac taacgatgtt tcagaattag actgtttatt ttcttgacgt 2956501 tctttttggg ctttttcaag ctcactattt actgaatcaa gttctttttg tatgtcttca 2956561 tcatttgtat cctcagataa aagctgctgt ttatatttag ctagggcaaa gtaaatataa 2956621 tcattgtatt ccagcttacg gccgatactg atcgcttctt tgtattctcc tcgaccataa 2956681 tcaatccaat ataagaaatg ctgagggtct gattgaaggg tgactaaatt attttctata 2956741 tttttggttt ttgcactccc caggttttcg acctcaacat aggacgtcgc cagctgatac 2956801 tgcaccgatt caggcaggct ttccgcatcg tacttggaca gtgtgctgat gacttcactg 2956861 tactgcttgt ttaagaacgc acggttgctg tccactatcg cctggtgctt tggctgcgcg 2956921 aaaaataagg cgtacatcga ataaataagt gccggtacaa gcaaaacaat gagccccagg 2956981 ccgatatatc gctggatgtt ccacttcttt ctcgggatat gtatgtatgt ttttgctttg 2957041 gcttcgagct catcaatatg ggtttgaatc agctcgagca aatcatcata ggattcagca 2957101 tctaatatcg cctttgcctc tgcggagaac gtcagcgttt cattgaattt caggtagtct 2957161 tcaaacgcaa aagcgccgtc aactgccaaa gccgctgccg ctttcagctc ctgccatact 2957221 ctttcctcat cacgctcgta aggaggaatg ctttctttta ctccataatg gagaaaataa 2957281 ggcgtaagcc ctttatcgaa tacaatgttt tcaggagcga caatcaaatt cagcctcgac 2957341 agattgtgct gctgtacggc ttgaacaagc tgataggcaa actgccattt acttttttta 2957401 tccttagctt tcatgaagcg gaatgcttta taggaggagg gaggttggat tgtgatgatt 2957461 acttcatcat ccgtcacatc gatttcttta tgaaaaaatg gatttatatc tttgatcacg 2957521 ttagcttcaa gaccgtcgag aagctttatt ttttcccgtt gaaaggtaaa tgtatagccg 2957581 gcatctgttt tctcggcaac agcttctaat tggttttcta aatatgattt ttgttcacct 2957641 gacattcaac cagatccttt cataatattt caagccggtc tccgtttgta atgccgcaat 2957701 cagacagctt gcattctccg gaaaacacct tatccttgtt caccactctg atccagtgcc 2957761 cttcgcgcgg aggcatagat acgctttggg cctgccaagc aatatcaatt acttttttca 2957821 ccgggtggta atctgacaat ctgagatcaa agacactgcc gttataatgt ttcaaatcta 2957881 ttgtaatatc aatatacatt taggatcacc cttacataga aagagcgccg tcttcttttg 2957941 aatcaggcgc tccttccctt tcatactgtt atccgcggat ttgatttgcg atgtcttggt 2958001 cagtagactc aagtgtattt gctgtttgat caagctgctg attcacatct tgaagcaaat 2958061 ctgacatttt gataaatgaa ggtttgagct gctcgtattg atctgcgaac gcttcgcttg 2958121 aagcaccttc ccacatgctt ttcaaatcag agatcattcg gtttaaacga tcaacctgat 2958181 ttaatacttc ttggctttca acgccgtatt gcttcgccat cgctcttagc tcttcgggtg 2958241 tgacacgaat taatcctgcc atattcctca ttacctcctg tgccatcagc ctaaatatgg 2958301 gctaattcac ttatttttag aacgtcatta ttataaaaac agtttttcgg catagtcaaa 2958361 caaatatgtt ttaattttac aaaatgagtc caatggttta ccccgaatca ctcaaaaatg 2958421 acatatactg taaagtaaat aggtttattt tcttaatctt ctcttcattc tccgaataat 2958481 ccaaaagacc caaataactc tccaactccc aaaaaaaacc tttcagaaaa tttgatgcta 2958541 cagcaccatt tctgaaaggt tcagtttttt ctttccttaa ttagtcttgc ctccgatgac 2958601 tttcttagaa gattaatagg ataagctgtc gtattatatg agacatacac tgtcctgcaa 2958661 aaaggcgatt acaccgccaa atgtatatag aacgtttctc tcatgaaatt gtttttttgc 2958721 ttctgttctt tgttgttgat tttcacaaac aacaacaatc ataataaaag gaaggggatg 2958781 agatgtcaaa gagaaatcaa gcacgaaaag tagggagatt tatgaccatg ccgaatgatc 2958841 cgtttaaata tagttttgac agacttgaag atgtggctga tcatatcagc gacgttctgc 2958901 ggtgcccgat caccatagag gatgttaacc acaagctgct tgcctacagt acacacagcg 2958961 actgcacaga ccctgcccgg acgtctacca ttattggcag aagggtaccg gagaaggtga 2959021 ttaacaagct gtggaaagac gggacaattc ctgctctctt aaaaacggac cagccgatca 2959081 gagtcaagca aatcgatgaa gtcgggctga gcaatcgcgt cgctatttcg atttggaaaa 2959141 acaagcaagt acttggcttc atatgggcgc ttgagatcca aaaaacattg tccgatgaag 2959201 atctgctgac attgcaaatg gcagcaaaag cagtgaaaaa caagcttctc aaacttcaaa 2959261 tcagaaaaac gaaaaatgaa gaacgcagcc aagaattttt ctggaaaatg ctgaccggac 2959321 acatccatca ggaggatgat atggcggatg ggttccataa gcttggaatg gccgctcctt 2959381 cagagttttc cgttatgatc atccgcataa atggcgagct gactgaaaaa atcgaacagc 2959441 agctgcaata tttacaggaa acgacccagc aggtttacgt gctgctggcg accgtagatt 2959501 ccaatgaact tattatatta acctcaccca aaacagatca tccttttcaa gatttaaaac 2959561 agtttgcttt aagtacgcaa aaacagctga aggagcggta taaaatagaa gacgtttcta 2959621 tcgcttttgg cggaatatac aactctattt cttttgtctc ccgctcctat caggaagcat 2959681 tgtccgtctt aaaaacgaag gaacggttcg ctgaagagac caaacatctt ttcagctttt 2959741 ctgagttagg catttatcaa tacttagatg tcttaaatga aaaacggaaa caggcgggcc 2959801 attataatta ctcgctttcc aaactggaac aatatgaccg ggatcaccag tcaaatatgg 2959861 tagagacgct agagcgcttt attgaagcgg acagcaacgt gaataccgct tccaagctgt 2959921 taaatataca cgttaatacg ttgaattacc gactcaagcg gatcagccag atcgctgaaa 2959981 ttgatttgaa aaatgtgaat caaaaattca ccatctattt agatatcaaa cttcggcaca 2960041 tggatttgtg aaatttcaca aatccatgtt tttttatttt cttaatcaaa caaagaattt 2960101 tccaaaatat caagctacac taaaaatatc acatatacag gaggagacag atatgatcat 2960161 aggggttcct aaagagataa aaaacaatga aaaccgtgtc gcattaacac ccgggggcgt 2960221 ttctcagctc atttcaaacg gccaccgggt gctggttgaa acaggcgcgg gccttggaag 2960281 cggatttgaa aatgaagcct atgagtcagc aggagcggaa atcattgctg atccgaagca 2960341 ggtctgggac gccgaaatgg tcatgaaagt aaaagaaccg ctgccggaag aatatgttta 2960401 ttttcgcaaa ggacttgtgc tgtttacgta ccttcattta gcagctgagc ctgagcttgc 2960461 acaggccttg aaggataaag gagtaactgc catcgcatat gaaacggtca gtgaaggccg 2960521 gacattgcct cttctgacgc caatgtcaga ggttgcgggc agaatggcag cgcaaatcgg 2960581 cgctcaattc ttagaaaagc ctaaaggcgg aaaaggcatt ctgcttgccg gggtgcctgg 2960641 cgtttcccgc ggaaaagtaa caattatcgg aggaggcgtt gtcgggacaa acgcggcgaa 2960701 aatggctgtc ggcctcggtg cagatgtgac gatcattgac ttaaacgcag accgcttgcg 2960761 ccagcttgat gacatcttcg gccatcagat taaaacgtta atttctaatc cggtcaatat 2960821 tgctgatgct gtggcggaag cggatctcct catttgcgcg gtattaattc cgggtgctaa 2960881 agctccgact cttgtcactg aggaaatggt aaaacaaatg aaacccggtt cagttattgt 2960941 tgatgtagcg atcgaccaag gcggcatcgt cgaaactgtc gaccatatca caacacatga 2961001 tcagccaaca tatgaaaaac acggggttgt gcattatgct gtagcgaaca tgccaggcgc 2961061 agtccctcgt acatcaacaa tcgccctgac taacgttact gttccatacg cgctgcaaat 2961121 cgcgaacaaa ggggcagtaa aagcgctcgc agacaatacg gcactgagag cgggtttaaa 2961181 caccgcaaac ggacacgtga cctatgaagc tgtagcaaga gatctaggct atgagtatgt 2961241 tcctgccgag aaagctttac aggatgaatc atctgtggcg ggtgcttaat tcacaataag 2961301 cttgcagaaa gatttctgca ggctttttta ttttttaaaa ggaaaaaaga gaccatttca 2961361 cgaattatga ctatgaagtt gatcataaag gaggattcat atggctgttc agcaatatgg 2961421 cgtgttaaaa ggcatagtat tagacatgaa gcgggaaaca gatgatgaca gtcctcattt 2961481 ccaagtcaaa atgctcggtg aagagaatac gtattacagg tgcgccatca atgtgatgtc 2961541 cagttctgag gaatctgaag tattgtattt ggctgacgat cagtttgatt cgggctcaat 2961601 taccatcctt ccgaacatgc cgtatggata tacaaggatc aatgaagcaa accgtgaagt 2961661 ggcactggat tatgtgcggg gcaatttgtt tgacccgcgg gaaatgaagc ctttgcctca 2961721 tgaaatcacg ggacctgata atgatttaaa tgattttatt gaaacctata tgaagaaagc 2961781 acaagatgag aaaacgccgg tttatatatt cggttcaaaa ttcggccctg aacaggctgc 2961841 agataaaata ttcggcttta ccccgactaa cggaatgcac aatatccata tgaatcaagg 2961901 gaatgcaatg gatacccgct ggaaaaaaga caacggctct tggcatgacg ggggtattct 2961961 gattcagttt gcagatcagt gggccgctgt gtttttagcg tttttatccc aatcttggtg 2962021 taccgatgaa aacggaaacc ctgtcagaga ttgtgatcat acccaaacgt ctgcgtaaga 2962081 tagaaaaaga gactgcggca agcagtctct ttttgataag attacacatt ttcaacagtc 2962141 tttaggctgt ttggcctcat atcgctccaa tgcgattgga tatagtccaa acaagcttca 2962201 cgcccttttt gctcatgaac gactgtccag ccgctcggca catctataaa acccggccat 2962261 agggaatatt ggccttcttc attgaccagc accaaatatg tgccatccgc attttcaaaa 2962321 ggatttgcca ttctatttct cctcccttat ttattcaact cttccaattt gacagcgaga 2962381 accttgccga tttgagccag aggttcaggc tgacataaat ctttatgacg gcagtcgatg 2962441 tcgatttgtt caatctgtcc gttaatataa ggcttccacg agtcaggttc aatcgggtca 2962501 aaccattcag gaatgattgt tgatctgaaa aacaaaacat ttccgcggaa ggttttcggc 2962561 ttataggaac ctaaaatgcc gacagaattt acatacgtat tcttcaaatt taaaatgacc 2962621 gtttcatcca ggctcgcaag cgcactgccg tcacggcgaa gaatctcaat cgccgcttca 2962681 aaatctagcg gtttttcccc taagctgtct ggatcatacc cgcctaacgc cagaagggca 2962741 ataagcgctt cctcatcatc cggtgcctct tttataggaa ggaagtggtt cggataggcg 2962801 tccagcatca ccaacaggga tacttcttct ccttgatttt gcagctgggt agccatcgct 2962861 tgaacgacat tcccgcccag ggaccagccc agcagatggt acgggccttt tggctggacc 2962921 gttcggattt gtttaatgta atcggcagcc atgtcatcaa gtgttttcgg aagctcctcg 2962981 cgctgcccga ttccccgtgc ctgcaagccg tagatcggat aatctgttcc tatattggtc 2963041 atcaaaccgg cataacacca gctgagcccc cctgccggat gaacacagaa taaaggaggc 2963101 ttgtctccgc ttgttcggag cggcagcaga acgtcaagag cgctttggct tgatcccatt 2963161 tcaagtcttt cagcgagccc ggctacagta ggtgcttcga acaagttgcc gatgctgagt 2963221 tcaacgccga gcgcttcacg aatgcggctc atgagctgta cagcaagcaa ggaatgtccg 2963281 cctaaatcaa agaaacggtc atcaatgccg acacgcggca agtgaagcac ctccataaag 2963341 aggtcacaga gaatttcttc ctgcggcgtt ctcggtcctc gtcctgtcac tgccgctgcg 2963401 aaatccggag cgggcagcgc tttacgatca agctttccat tcggtgtcag cggcaattct 2963461 ttcatcgtca caaaggcagc aggcaccatg taatccggca gtctctcagc agcatatctg 2963521 cgcagttccg ccgtatcaaa tgtttcttcc gaagggatga cataagctgc taaccgttta 2963581 tctcccggct gatcctcacg aacgatcact gccgcatctt caagctgcgg atgctgaaca 2963641 agcgcggctt caatttctcc caattcaatc cggaatcccc gaattttcac ttgatggtct 2963701 gcacggccga catagtcgag agaaccgtca gcgcggaggc gggccacatc cccagtgcgg 2963761 tacatccggg tgcctggagg accgaacgga tcagctatga agcgttcaga tgttaaacca 2963821 ggccggccta gataacctcg tgctaacccc gctcctgata catacagctc tccggcaaca 2963881 cccggcggga ccggctgcag gcgttcatcc agcacgtata caccaagatc gggaatgccg 2963941 cagccgatca agctgtttgc ccgtaaagct gccatgcttc ggtctaattc gatatagctc 2964001 acatgcaccg tcgtttctgt aataccatac atattgataa gctgcggtct attttcaggg 2964061 tggcggttgt accaatcctc taaacggctg agttcaagcg cttctccgcc aaaaatgaca 2964121 tagcgcagac tgagtgcctg tccgagatcc ggctgttccc gttccgcctg cataaactga 2964181 tagaaagcag acggtgtctg gttcagaaca gtcaccccct ctttgacaag caggcgcaga 2964241 aacgcttctg gcgatctgct gacgtggtga ggcacgatta caagacgtcc gccatgcagc 2964301 agaggacccc agatctccca caccgaaaaa tcaaacgcat aggaatggaa catggtccag 2964361 atatcacctg agctgaaacg gaaccagtgc tcggtcgctg caaataaacg tgttacattt 2964421 tggtgaggaa tcatcacacc ttttggaaca cctgttgagc cggatgtata aatgacatat 2964481 gccgtattca aaggggaaag cggctgagtc ctatccttat tttttggatt acctgcaggg 2964541 tacgtgttta gtttctctgc cagctcggga tcatccagca cgattttcgg cacgttttca 2964601 actggcggaa tgtgatttgc agctttagtg ttcgtcatga taaacgcagg ctgtgcatct 2964661 tttagcataa aagcaattcg atcagccgga taatccggat caagagggag ataagctgcc 2964721 ccggccttta gcaccgccaa taggccgaca gccatttcca acgatcgggg cagtgccaat 2964781 gccacaaatt gctccggccc gacaccttca ctaatcatca ttcgggcaag ccggtttgct 2964841 ctttcattca gctctgcata gctcagttcc tgattttcat atacaacggc aatggcatca 2964901 ggacgtaaag cagcctgctt ctcaaattgc tctggcaaac atgcgtgcgg aatcttttca 2964961 gatacacttt gccaatcagt caccatgctg ctgtgttcct ctggcgcaag aatatccaga 2965021 tttccgattt gctcgtcagg atcagactcg gcagcctcca acaggcgcat caatcggtca 2965081 gcaagagcct gagcagtttc ccgtttgaaa agatcagtgc tgtattcaag cagtccttcc 2965141 attccgtttg gtgtcccgtc agcaaggcga tcttcactaa tttccagcgt caaatcaaac 2965201 ttggcagaac cgacactgtt gattcgcagg ctgctctcca tatcaggaag atgcagttca 2965261 gcgtccggtg tgttttggaa cgcaagcatg atttggaata aaggatgcgt cgcacgcgaa 2965321 cgagccggat tgagcacctc tacaagtctc tcaaacggca gatcctgatt gtcataggcg 2965381 gccagattca cttcccgtac tctgtctaga agctcacgaa agcttgggtc accggacgta 2965441 tcagttctga gcaccaatgt attaatgaac agccctacaa gatcgcccag cgcatcatca 2965501 ttccgtcccg cgatcggact gccgatcgga atgtcggtgc ccgccccgag ccttgtcaat 2965561 aaagcggcga gaccggattg aagcaccata aacaggctca ccctatttgc gcgagccagc 2965621 tcctgcaatc gcttgtgaaa ctcgggctca atacgaaaat gaatcgtatc tccatcatga 2965681 ctcggctcag ccggacgtga ataatcggtt ggcagttcaa gctgatcagg caggtttttc 2965741 aaggtttctt tccagaaagc aagctgtccg gcaatcaagc tatttggatc atcctcgttt 2965801 ccaagcagtt cttgctgcca aagcgcatag tctgcatact gcacagcaag aggcgcccat 2965861 tcgggagatc gtccgtggca gcgagccgca taagctgtcc caaggtctct ggtcagcggt 2965921 gttaaggacc agccgtcccc gacaatatga tggacgagaa gaagcagcac gtactcgtca 2965981 ggaccgatca caaaaagctc ggcacgaaaa gcaggttcag ctgcaagatc aaagctgtag 2966041 cgtacagctt cggcaagccg atcagaaagc tccttctcag caatttcagt aacatgtaac 2966101 tcgggacagg ctcgatcggc atctaaaata tgctgatagg atgtcccctg tgattcaggg 2966161 aagatcgtcc gaagactttc atgacggcag acgaggtcat aaagtgccgc tttcagcaat 2966221 ccttgatcca actcacctga caaacggaca gcaaccggaa tattataagt aggactcggt 2966281 ccttccagac aatgcaggaa ccatagccgg cgctgggcaa atgagagcgg gatcttttca 2966341 ggccgctcag ctctctgcaa agcgggacat gcactctgcg ccaaatcaag atgggcagcg 2966401 agtccggcta ctgtcggttc gtcaaagagc ttggcgatac caagttcggc tcccattacc 2966461 tcgcgaatgc ggctcatcag acgggctgca agaagagaat ggcccccaag ctcgaagaaa 2966521 ctgtcatcga taccgacgcg tgccaaaccg agaacctctg caaacaagtc acacaatatc 2966581 tcttcctgag gagtccgcgg ggcccgatca ctgacagatg tgctgaagtc tggtgccggc 2966641 agtgctttcc ggtcaagctt gccattaggt gttaacggca gctcgtccat ctccacaaac 2966701 gccgacggta ccatataatc aggaagacta gcccccatat aacgacgaag ctctgcagta 2966761 tcaatagcag catcagcgac tacataagcc gccaatcgtt tgtctcccgg ctgatcttcc 2966821 cgtacgacaa ccgcggcctg ttcaatgtgc gggtgattgg caagcacggc atcaatttct 2966881 ccaagttcaa ttcggaatcc gcgaattttg atttgatgat ccgcccgccc gatataatcc 2966941 aaagacccat cggcgcgcca gcgggcctgg tctccggtcc gatacatccg agttcccggc 2967001 ggtccgtatg gatctgcaac gaagcgctcc gccgttaaat caggacgatg gaaataacct 2967061 ctggccaagc cggttcctgc aatataaagc tctccgacaa cgcccggcgg caccggctgc 2967121 aatccattat caagcacata cacctgcgtg ttccaaatcg gtttcccaat cggaggaacg 2967181 cccttcagcc cttcttcaag aaaagctgcg gcagaccaaa tcgttgtttc agtgggaccg 2967241 tataagttcg tgactgaaca atgaaggtct tgaagttcct gcaaaagacc gctcggcagc 2967301 gcctcgcctc ctacaagcac tctaagcccc cgaagtttct caggttcact cgttaccaaa 2967361 gcgtgccaca gtgtcggtgt cgcctgcata atgttaatat cgaaattttc aatcatttga 2967421 gctaatgcct gcggctcacg gatcgtttct ttctttgcga tcacgatttg cgctccgcta 2967481 atcagcggaa gatataactc caatgctgaa atatcaaaag cgacagtcgt cacagccaac 2967541 agcctgtctt cttctcctag agaaaatgcc tcctgcatag acagcagaaa attgcttaag 2967601 cttttctgtg tcacaacgac tcccttcggt cttcctgttg atcctgaggt atagatgata 2967661 tacgcaggat ggtcaagcga aaccgataca tcctgatttt ccggcgaata gcgttttata 2967721 atctcctgtg taacagcctg atcaagcaca agctcaggta cagccaggtc atcaggcaga 2967781 ctggctgcta tttcctcagt cgttatgatg catgaaggtt tcgcatcctc cagcatgtaa 2967841 gaaatgcggt cggctggaaa ctccggatca agggggagat acgccgcacc agtcttgagc 2967901 acaccaagca ttgaagccac catctcaggg gaacgcggca gcgccaaagc gacaaattgc 2967961 tccggaccaa tccctttttc gatcaacaga cgcgcgaggc ggtttgcctc ttcattgagc 2968021 tttcgatagt tgacttgaat gtcatcacac atgagagcga tacgttctgg cgtaagaact 2968081 gcctgctttt cgaacatgtc ctgaaggctg accagcttct cggattttgc cgtctcattc 2968141 catttagaaa tgactttttc tttctcctct ggcaacagaa gctccatttg cccaatcagc 2968201 atgtcctctc cggcagaagc cgtttgcagc agctgcaaaa tacgctgctg atgaagctta 2968261 atatcagact cactgtatac ctcgggattc gcatcaacat caattcgcag cccgctgccg 2968321 tctgttctgt catatacatt gattgataga tcatcaacag gaccggctga aagattatgc 2968381 gttgtgcccc ggacgccggc aaagtcgaga ccgtaatcaa acggcataag attgatttga 2968441 gggccaaata atctatgatt ttctcctatc aatttcagat cgcgcctaag ctcttcatgg 2968501 cgatacttat gatgtcgccg aatactgcgg atttcccggg aaatttgctg aatcagttca 2968561 gaaaagctca tcgaagagct taccgtcagc cggagcggga gaaggttcat caccatagcc 2968621 ggtacattca gtgacgcgga ccctatccga cccatcatgg gcaggccgag cacaacatcc 2968681 tcagagccgg tcatacggtg cacataaaca gctgacaccg caatcatgac ttcatgccag 2968741 cttcctgaga aatagcgcgc cgcttctttt aacgcgttta catcagacgg aggcagatat 2968801 gccgtatgac gaagaaaact gttagatgtt cttggcgccc gatcagccaa gctcacaact 2968861 tcaggtgcat ctgcaaaacg gtccagccag aattgacgat ccttctcata ctgctctgat 2968921 ccgcgataat ctgtatcctc ctccaaaatg gcctggagag acccaaagga acggctttta 2968981 gctgtttgtc cttttataag ggcagtatat gtacttgcca cacgctgggc tatcagggaa 2969041 aaaccgaagc cgtcgatcgc tatatggtga atgcgctgat accaaaagaa acgatcaggc 2969101 ccggcaataa acagagcttc attgaacaaa ggggcatacc ctaaatcaac cggctttgct 2969161 aaatcagctt tcatccagtt taatgctgtt ttttccggat caggctcaga gctgacgtca 2969221 atgacgtgca gctgtacatc cggagacggg tttatcatct gccaaggccc gtccatattt 2969281 tcaccgaagc ggacatgcag cgattccgct tccttgatca cgtgccgcaa agcttcttca 2969341 aaaagagcaa tattgactgg tccattgatt tctatatatt ccgctgtatt gtagattgga 2969401 ttgtccggat caagctgctg agcaaaccat atgccagttt gcgccccggt caaagaatat 2969461 tgaagatctt ttgtatcagg catccgtttg tttaccctcc ttttataaat aatccgcgtt 2969521 tggcagcact tgctggctgc gagttgtgag caatttctgc cattcttcga tcgttgggcg 2969581 ttcagccaat tccacgaaag tcacctctgc cccttcacgg cgccattgtt ccaccaatgt 2969641 catgatcctt accgaatcaa gaccacgatc gagcaaatcc tcttgatctg tgatgtcttc 2969701 cggtgtttct tgtagaagct cagcaatttg tttacggata ttctcacatg taaacacgtt 2969761 ctttttgcca gtgtttgctg acgttttttg aacgtctgcc ggcgcattct gcagctgatc 2969821 aagaagactg tcagtcatca cggtaaacgc acagcgtcca gccgcatatt ccagcgccat 2969881 ttgatgtttt tctaatgaaa aatcagcaac tgcatctccc acaaaaaagg ctttaatatc 2969941 ctccataaat gcttcacatg ctgtaacaag acagccgata tgggcgtaaa ttcctgtaat 2970001 gatcagctga tcgcgtccct ctttgcgcat catttcaagc agattcgttc tcttaaacgc 2970061 gctgtatctc cattttgtca gcacaagatc atcatcctct ggtgccagct cggttataat 2970121 tttctcctca taaggaccgc tgtttaatcc cgggccccaa aagtctgtca gcagcgcacg 2970181 gtcatccgga ttttggcttc ccggctgtgc ggtatagaca acaggaatcc caagctgaac 2970241 acattgattc ttcagctttc gtatattcgc tgaaagctct gttaccggag acgctcccgc 2970301 tgtgaaagca tcaacaaaat agttttgcat atcgtgtatt aacaagacag cccgattcgg 2970361 atcaggcacc catgatactt tgttttgcgg catatcagat gctgtcggca tttgatacgg 2970421 ctgaatggca ggtatagcca tatgaacact tcctctcaaa ttgttgtttt attttttaaa 2970481 tcctgcaaga agcttctcgg aaatggcttc acggagcgct tttttgctga cttttcctac 2970541 tcctgtctgc gggaaggatt cgacaaattc aactcgatca gggattttat atgccgccag 2970601 tccgcgctct ctcaaaaatg ctttaagctc tgcggctttt ggggcttcat cccggggaat 2970661 aatgaacaca caagatcttt cgccaagaaa ttgatcaggc atggagacca ttgccgcatc 2970721 atggacagcc ggatgcgcca gcagatgatt ttctacctct tcagccgcaa ccttttctcc 2970781 tccacggtta atttgatcct tcgcccggcc ttcaacgaca atatagccgt ctcgtgtcag 2970841 cctgacgata tcacccgtac ggtaaaaacc gtcctcagta aatgaagcgg cgttatgctc 2970901 ttctgcctta tagtaacctc gaattgtata cggcccccgc gtcagcagat ggcctgtttc 2970961 accaggtttt acgtcgcgat catgatcatc ccaaacacgc atttcatcat atggagacat 2971021 cggttttcct tgggtgttga caatgatctc ctcaggatca tccaatctcg tataattgac 2971081 gagaccctct gccattccga acacctgctg cagcgtgcag ccgaaaacag cttttaccct 2971141 gcgcgcggct tcagcactaa acttggcacc gccgacctgc agcacttgaa ggctggataa 2971201 atcatcacgg cgtgaggatg ccgcatccat ccataccatc gcaagaggcg gaacaagagc 2971261 ggttatcgtg accttttccc gttcaattaa aggaaatgcg tcatctggac ttggagaagg 2971321 agataatacc actcttcctc cagcgtataa tacgccgaga acgccgggtg agctcagcgg 2971381 ataattgtgt gccatcggca gcgcggccaa gtacaccgtg ctgtggtcga gccagcagac 2971441 ctccacactc cgcttcaggc tgtatatgta gtcatcgtgg gtcctcggaa tcagtttcga 2971501 tagcccggtg ctcccgccag aaagctggag gaacgccaca tccgatgatt tgacttcagg 2971561 cagttttaca ggttctgcat gcaaatcctc cagcggtaaa aattcctctg cctcacctgc 2971621 gacaatgatg tttttcaaag tcggcagctt gctttgaacc tgtctggcaa gcgaacggta 2971681 gtcaaaaccg gaataagcgt cgggaatgat atatgcagcc gcttcagcaa actcgcaaaa 2971741 atatgtaatt tcactgcttc gatgagaagg cagtgcgaag actggaagcg cccccagacg 2971801 gaaaagcgcg aaaatgactt caaaaaactc tttgatattt ggcaactgca ccacaacacg 2971861 atccatctgt tgaatgccga gcttttgaaa tccggcagcc aggcgatcag cccttgtgtc 2971921 aagctctcga tagctccaat gggtgtttcc gcatgtaatg gcaatgcgat caccatattt 2971981 ggctgcccgg tcccttaaca aatctccaaa cgtctcaccg gcccagcagc cgttctttcg 2972041 ataggtctca gctaactcat caggccaagg cgtaaatcct ttcagcatgt tgtatccctc 2972101 cagcaattca ttctgttcat atgtgatcca cgcccattgc ccgcagcatt gtccgaaact 2972161 ttgcggacgt ctcctgaagc tcgtcctcag gctttgaacc ggccacaaca ccagctccag 2972221 catacaggcg gagtgagcgt tcttctgctt ctgcacaacg gatggtcacg atccattctc 2972281 cgtcaccggc atcgtcacac catccgacca tgccggtaaa gaaaccgcgg tcaaatggtt 2972341 caatgctgag aatcgcttct cttgcaagat cagtcggtgt tccgcagacg gctggcgtcg 2972401 ggtggagcgc cgccgccaat tcaagtgcgg ttacagacgg gtcggaaagc tctcccttaa 2972461 tcacgctgga caggtgccac atcgtttccg ttttgatcag tgaaggcttc tccggaacct 2972521 ccagcgtccg gcagaaaggt ctcagcgctg ccgcaaccgc gtcagcgaca accgcgtgct 2972581 catgaagatc ctttgcggaa gaaagcaatt cagctgcccg gcgctggtct tcaacaggat 2972641 cattactgcg cggtcttgag ccggctaatg ggttggaaac gacctgtgtt cccatccttg 2972701 aaacgagaag ctccggactt gctccgagca atgttctgcg gggagacgtt tcctcctgac 2972761 tggacacgtc tgcggcaaac gtgtagccat gcgagttatg ctgagccaga tggcgaagca 2972821 attcatccgt ctgaatcggt tcaggcgatg tcaaatgcag cgatctggac aggacgattt 2972881 tgctgagtgt tccatcggca atgcgtgcca gcccttgttc aacaccattt ttataatcct 2972941 caggttcagg aacaggcttt atgtggtatg tatgcccagc ctgctgttcc ttttcctcat 2973001 gatcaaattg aagcggtcct gaccagcgca cttcttcagg tacaacgagc cgcgctgctt 2973061 ttacttgatc aaaaggaacg gccccgacaa caagcggccg gctttgccct gattgttttg 2973121 cctgacgtaa cgcctctgca attcggccag aaagggtttc catttggttt tgcccgtctg 2973181 cctccggtac aatttcacat atgcctttcg ctaacagtac acgatgagga gacgctaaga 2973241 aaaaggcgcc cggctgatat tcatgaagca aatgctccgc ttttgtttct gttataacgt 2973301 tttgatccaa cattctcatg aacctccttt aaattcagtt acacgcctaa ggtcgcgccg 2973361 ccatctacgc ataaattatg catcgtaata tgccctgcct ggccagaaac caaaaagagc 2973421 accgcatccg caatatccga aggcttggct agttttttga gcgggatccc tgttttaaat 2973481 gtctcaagtg atccttttat gacttgctcc gctccattct cgtcggccca taatgaccac 2973541 tgcatgtctg tttccgttga tccgggagat acaatgttgc agcgaatatt gtattctgca 2973601 agctcaaggc caaggcattt cgtaaacatc acagccgcag cctttgaaga cgcatatgcc 2973661 gccatagatg ttcttggtac accggcagca ttcgatccga ctgttacaat cgaacccgat 2973721 cttcggtcca tcatatattt gctgactgaa cgcgaggcgt taaatacgcc agtcgaattc 2973781 actgagaacg tcgcctccca ttcctcatcg ctaagcgaat ggatcagtcc cgggcgaagg 2973841 acacccgcta cattcactaa aatatcaatc ggccccattt cacgttcgat gcgcgccgtg 2973901 atctcgtcaa tcgccgcgct gtctctcaca tccgcaggaa aagcttctgc atggcggcct 2973961 tctgctttga ggctgctcac aaccttttcc agcttttcag gattataatc aactgccgca 2974021 atatgtgcgc cttgactggc aagcgtccgc gcaacagctt cgcctattcc ttgggcagcc 2974081 cctgttataa aagcaatttt tccctctata ccctttgcat tcatatcatc aattcctttc 2974141 ttcgctctaa atgccaaaca gacatccagc gaaaaagact gctgcgcctt gaaaaacgca 2974201 atctattgat aatgattatc attatcaatt ataaaaataa tcatatccaa atgtcatgtg 2974261 acagtcaaat ataatttcag tgacaaatat ttttttaaag gcaaggctga gtatgtctca 2974321 gcccattgat agatgcggtc cgtcagggtg aagcgcaaaa cgcagcgccc tgctgaccaa 2974381 aacaggaaga actgaaatat gtccttctcc tgaaaactcg caaaattctg cccgtatacc 2974441 ttgttcagat aaaacggcca gccgctcata aagctccctt gcattatcat tcatccggct 2974501 tttatgatgc tgctctaatt ctcctgcggc aagcaggata ttgataggct gattgttttt 2974561 cttggtgaga gagacgaaat ggtccgtttt cttgagaata aacggtttat tccaatgaat 2974621 ggacggactt cccgcgatat acgtttgaaa cgcatcgggc tttgttagca gcacctgcag 2974681 cacgaaaagc cctccgagcg aatggccaaa gattgtttgt ctttttttat caatctggta 2974741 atctcgttct atctccggtt ttaaatcctc ttcaataaat ctgaaaaagc cctccgctcc 2974801 gccatgctcc ggccattctc tgccgtcggg cctttccggc agcttcgatt gggctgttgg 2974861 cattgtaaaa tcccggtggc gtgctgagga gaacggctcc gctgtctcat agccaatgcc 2974921 gacgatcact gcagggatca ccccggtttt ttcgggtcgg cgtccctgta ttcgaacggc 2974981 ttccgtcatc gttccgaaga cagaattggc atccagcaga taaatcacag gataaccagc 2975041 gggtggcggc ggcgtactag gtttcgagat aaaaatgtga taggtacggt tttcattgcg 2975101 tgaagacatc atacgcactt ccgtaccagg aatcgtaaat gcgtttgatg tcccgccatt 2975161 tgtccggtct gttgtttgtt ctttcatgca gtacgacatt cctctcctta aactaaaccg 2975221 caatgtatga taatgatttt cactatcaac tagacacctc aaataatagg ttttcttcca 2975281 aagaaagtca actttttccc gaataaaaaa ggcaccttga tcaaataagg tacctgcaga 2975341 ctatcaatat ggaagtaaaa acctaataaa gatgcgtatt gtcctatttg aaatagaacc 2975401 ttaatcccat gtaaaccttt gattttgcca agggtcgcct ctcatgtgat agccattccg 2975461 ctcccaaaag ccagggtgat tttctttcgt aaattggatg ccgcgcagcc acttggcgct 2975521 tttccaaaaa tacagatgcg gaaatacacc ccgcagcgga aagccgtgtt caggggttaa 2975581 aggttcgcca ttatgcgcat aagccagaag ggaagtttcc gctaagaaat catcaagcgg 2975641 cagattggtc gtccagccct cttcagcatg taaaatgacg tagcccgctt cttcttttac 2975701 acccgctttt tccgctatat cacaagcccg cacgccttgc cacacattat caagccttga 2975761 ccatcccgtg acgcaatgaa tgtcgttttt cgattcatac cgtggaaagg ctttgacatc 2975821 ttcaaagctt agcagcatcg gatggtcaac caaaccgtat acttgaagat tccatttcgt 2975881 catatcttcg taatatggga catctccggt atgaagcaca ggaaatgaag tggtgacgtt 2975941 ttgatttggc ggcactcttc cagattgatc ggactgtctt gtttttccga aatacatatg 2976001 ggcctccttt ttgttaacct aatttaaaat catgttgaca atctttttgt tctttattac 2976061 tctatgattg tgtatgtcaa cctaaggggg aacaacgatg aaacaacgta aacttcgtgc 2976121 gggagatatg gcgctgattg gcatgttcgc cgcacttatg gctgtcgggg ccaacattac 2976181 atcagtagca ccctttttac aagtagccgg cattccgctt tcgatgcagc cgtttttctg 2976241 tctcttggca gctttgcttc ttggcagcaa acgggcagcg attgccatga ttgtatatgc 2976301 acttgtggga ttggccggag cgcctgtgtt tgctcaattt tcagcaggct tcgcaccgtt 2976361 tgcagggaaa agcggcgggt ttattatctc atacattccg gcagcatttg cagcgggatg 2976421 gtttttagaa cgaaacattc agccaagtaa aattcgattt ctcattgctt cacttatcgg 2976481 aacggcgatc atgtatctca tcggcactac ctatatgtat cttgcactga agctgtggat 2976541 tcatacgcca gtgagctacg gcacggcttg gggctttatg atttggttta tggtaaaaga 2976601 tacagcgctg gctgtgatac tgtcgtttat cgcaccagca atctaccgct ctattcataa 2976661 agcaaccggc tttaacagaa atcacatatc atctacgtaa aaaccgttct attggacggt 2976721 ttttttatca taacgagaaa aggctcccca gtaaagggga gcctttttcc tataaaacaa 2976781 gcgctgcaat ccagccaaag atgacaagcg gaatattata aaatataaat gtcggcacac 2976841 aagtatccca aatgtggtga tgctggccgt ccgcactcaa acctgaagtc ggcccaagcg 2976901 tactgtcact ggcaggtgaa ccggcatcgc caagcgcagc agcagccccg ataatcgcaa 2976961 tcgttgccat cgggctgaat ccaagctgca tgcatagagg cacgaaaatg gttgtgataa 2977021 caggaatggt cgcaaaagaa gatccgatcc ccattgtaat taataagccg acaatgagca 2977081 tcagcaatgc gcccaaggac tgactgtgtc cgataaaacc agctgacgtt ttgaccagtg 2977141 actcgacatc tccggttttc gtcaatacgt ttgaaaatcc ggctgcaaca agcatgacaa 2977201 agccgataaa ggccattaaa accattccat cagtaatcag tgagtccgct tcatcacgct 2977261 tcatcacacc gctgacaaac agaacaatca gaccagcgag cgcccccata atcattcctt 2977321 ctactcccaa agtctgagat aagtaaagct ggacgccgag tgacacaaca atggctagaa 2977381 ccgcgatacc aatacttttt ctcgtatatg gcgatgcttc tgcacctgaa atgtcttttg 2977441 tttcatattg tttcggttta cggtatacga tcactgataa aataaggccg acaaccatac 2977501 ctgcaactgg aataatcagt gcgtacggaa tatcagcaag cggaacgttt aacccggcat 2977561 ccgccatatt gtccttcagc atgccttgga agatttggcc gaaaccgacc ggaagcaaaa 2977621 tataaggagc cgttaagcca aatgtaatta cacacgcgat cagacggcgg tccatttcaa 2977681 gttcattaaa gattttcaaa agcggcggaa tcagcaccgg gataaacgcg atgtgaaccg 2977741 gaacgacgtt ttgcgaaaaa caagatacaa ttaaaataat cagcacaatc agcaccttag 2977801 acagtgcttt ttttcgagaa tcttctttat ttccgattaa tttaacggag gcttccacca 2977861 ttgcgtccgg aagacccgtt ttcgtcaaag cggcggcaaa cgcgccaagc atggcatagc 2977921 taactgcaac ggtggcattt ccgccgagac cgtctgtgaa agctttaacc gtttcgccaa 2977981 gaccgagccc gcctgttaac ccgccggcca aggcgcctat aattaatgcg ataacaatat 2978041 tgacacgcag caggcttaat acaagcataa gcaggactgc gatgacgact gcattcatga 2978101 tgatacccct ccaaaaatcc tttagtttgc taatgtagta gataaataaa gtacgaacgt 2978161 atcgtatcat aaccgatcca ctttagtcaa ctaaagattt cggaagaaaa aatccctgcc 2978221 gcatcataca gcagggattt ttcattactc gtttttatct tcttccaatg taaatcgctc 2978281 cgcaagtgta gccagtgttc ttgccataac gccagtagcc ccggccggtc cgaagcaggt 2978341 tgctttattg gcagtcgctg tgcctgcaat atcaaggtga acccaaggtg ttgactcagc 2978401 gaattcacca agaaacgttc ctgccataat cgcatgtccc tcgcgtcccg gtgaattgct 2978461 gagatccgcc atttggctgc ttttcacgcg ttttttatcc ttctctgtta tcggcagctg 2978521 ccagatcgcc tcgccgcact cttgtgcagc atcagctacc tgctggtaaa agctttgatc 2978581 atttgtcatt gcaccggttg tttctgttcc taatgccaca acgacgccgc cggtaagcgt 2978641 agctacatcg acaagaactg atgcgccatg ctgtttcgcg tatgtaatgc catctgcaag 2978701 cactagcctt ccttcagcat ccgtattaag gatttctatt gtttttccgc ttaaagatac 2978761 gatcacgtca tccggcttca tggccccgcc ggagatcata ttatcggttg atggaataac 2978821 gcacagcacg ttttgttcag gacgaagctc tccgatcgtt tccatagccc cgagaaccgc 2978881 agctgctcct cccatatctg atttcatgcc aacaattcca gatttcgttt taatggagta 2978941 gccgcctgtg tcaaaggtaa ttcctttccc gactagtccg acgacgtctt cccattcctt 2979001 tttgccctga tatttcaaca caatcatttt cggcggttcg gtggagcctt ggtttaccgc 2979061 aagtattccg cccataccga gctcttccat ctctgatttc tccaatatct cacactcaaa 2979121 atcatatttc gccgcaagct cttcagcata cgaagcgagg tcagtcgctg tcagcatgtt 2979181 tcccggcata ttcacaagcg ttctagccga atttgtccct tgtccgtatg cctggccgac 2979241 gcgaagccct gcctgcactt cctgtgtatc ttcatctgtt acaacataca cggcttcaat 2979301 ttgtttgtca ggctcatttg atttatgctt ataatcctgc acctcatagg aagcaagcag 2979361 gcagctctca gctaaagcat gagcggcatc ggctggaggc acgtcttccg aaataaacgt 2979421 atcaagcaga acagcagttt cttgttttcg atctttatga atggcttgaa aaacatgagc 2979481 aaaacgttcc ttcgcctgtt caaacgaata atttgcttct ctccccaggc caacgaaata 2979541 aatccgtttc atacccgcag aagatggagg gaatactttt gatacttgat tcggtttcgc 2979601 agagacatca ccctctttta aaagctgtgt cagatggcct tcgagcattt catcaatttc 2979661 caacgctttt cctgtcagct ggcttttttg aaaaagcccg acaacaaggg tttctgtatg 2979721 ctctgattgt tgaaccgcat aaaacatgag gcttacactc ctaacgtaat gggtatttgt 2979781 aatgaacaat ggtataatag gaaaaacatt ctttccacta tacttatttt aacaaacaac 2979841 agtctaagac ttgctttttt cttttgaaac acgaaggatt tttcaaatag aaaggatgtc 2979901 gccgatggaa cttttaacga attttccttt attatcaagc ctggccgcaa ttatttttgc 2979961 tcaggtcatc aaagtgccca tacagtttat cgtgtccaga aaactggact ggtcgctggt 2980021 cacaagcaca ggcggcatgc ctagctctca ctccgcagcg gtcactgcgc tttctacagg 2980081 cgtagccttg gagcatggat tagactcctc actctttgcg gtttccgcca ttttcgccgt 2980141 cataaccatg tttgacgcaa ctggcgtcag acgtcacgcc ggtgagcagg caacagtcat 2980201 taataagctt gttattgatt ttaaccgttt cgtaaatgaa gcgaaggact tccctaaggc 2980261 tgcagagaaa gaaaagcaaa aaaagctgaa agagcttctc ggacatcagc cgatcgaagt 2980321 ctttttcgga ggattaacag gtattttact gacattggta ctcgcttact ttttcatgta 2980381 aaaaaaacgc tcctgctttc gctggagcgt tttattcttt caccgtttta tattgatttc 2980441 tgaacacttg caaagatttt gtttcattga gcttctcaag ctcatcctcg gtaatctttc 2980501 ccgttccctt tttaatcaca tatacatcaa gggttttttt gccccattca ttgtatacat 2980561 ctttgactgt ctcaaagtac agatcaaggc ggtttccctt aatagctgat cctgtgtcgg 2980621 ccacaactcc gagaccgtag ttcggaatga ataaaattgt tccgatcggg aaaacggacg 2980681 ggtcagcagc aaccgtggaa tataaatccc gtttcacttt cacacctgaa tatgtaagcc 2980741 cgtataatgg atcaccggga tttttgcccg tcgactcagc tcctgctgtg tagcctgttg 2980801 ctgttactct ttggactgga tattcatccc aatcaaatgc ctcttctaac ggttttgttt 2980861 tatcctcagc cgcggacgtg gtttgtgttt gtttctgctg caatgctttt aatctcagtc 2980921 ctgcatgctt caagtgcttt tcctgatgtt cctgcaccca ttttgacaag tccttcgctt 2980981 caattcctga cactgataaa aatgtcgtgc caaatgcaag cagaaataaa caggtcatca 2981041 gcaaacgtct gatcatattc aacatcattc acctctcctc cgaatcattg ttcccaagtg 2981101 gagagagcat tattcaaaat ggtgaatgag ctgaacgcat aaaaaaagct ttctttagaa 2981161 gaaagcggca tttaaaacat ttgatatcct ctttttctaa gcatgttgat cgctataccg 2981221 gacacgatgg cgccggccaa accgctgact aaaatcagca catcagcagc cgctaatgat 2981281 aagacacgat gaaacaggct ggcaaaggat tctcccggcg actggacata gctgatcagc 2981341 ttttctttgc tgataatgaa aaggcataca attggataaa tcacagccat aatccaagac 2981401 attctcagca gcatgtttaa taagaaaccg attccaaaaa acaagacaaa aaacaaaaca 2981461 attgagatga ttacgactgg cagactaatc aacctattcc acccccctgc gttgttttta 2981521 gtgtaacgcg ggggctgaaa taaagtcaac ggctggaaaa agaatgactg tcttttcctg 2981581 tcccctggca agacggacaa gtctctgaac cgccgagaat caattgaaaa tatcctttcc 2981641 ctgaacaaaa tgggcatgca tgtgaagcgg ttgtcgttgc agttttcatc taatcatcac 2981701 cctttttctt aattttctga taatatacca tatcaagctg tcaacaataa agtcagatca 2981761 tgtgacaaat cttttgatgt aagcggaaac atacttgttt tcctctcgtt ctctttttat 2981821 tttggcgttt tttaataaag aaaacccgct tccgcgggtt tttagaaaaa cttgaacttg 2981881 ccttttttca atgtcagtcc gagtccgcca atcataaaca gtgagcggtt atcaatgact 2981941 tttttcataa acgaagcggg cgtgcctttc agctttctgc cataaacaac cccaaccgcg 2982001 ttatgctcgc caagagaagc cactgttccc ttaatgtccg gcttgaattc ctcaagctct 2982061 ccgcctttaa taagcctgcc aaggttttta gcgaccgtta tgccctgctg cattgcaatt 2982121 tgcgcagtcg gcggatacgg gcgctctgta tcttcattca taaacagcga gctgtcgccg 2982181 agaataaaga cattgtcatg tcccggggcg cggagatcag ggttgacttt gactcggccg 2982241 cgcatattct caaaaccggc ttcctccaca atcggatggc cgcggacacc tgccgcccat 2982301 acaacggttt gcgatttgat ctgctctggt tcttcatctt ttttgccgac tctgactcct 2982361 tctggtgtac attcttgtac agccgttccg atcttgaact caactccgtt ttcctcaaga 2982421 taatgtacgg cgtaatcaac aagttccgga tcaaagcccg gcaaaacggt cggcgctgct 2982481 tccacacaaa tgatgcggac aaggcttctg tcaacgtcat attccttaca gagctccggc 2982541 acgcgagcag ccagttcgcc aagaaattca attcccgtaa atccggcacc gccaacaacg 2982601 atcgttaacc tgtccggccg tttttccgct tccgtattgt aagtcgcaaa ctgcagctca 2982661 atatgttccc gcagcaggcg cgacgtgttg atgttggcaa tcggaaacgc atattctttt 2982721 aagcctttaa tgccgaacgt ttcaggcacg gcgccgagcc cgatgactaa ataatcgtac 2982781 tgcaattctc cattcgcaag cacaactttt ttctcatcaa ttttgattgc ctttacggta 2982841 tcctgtacaa aattcacccg tgactggttg attacatctt ttatctgata acggcagcgg 2982901 tcatgatgga gcgtacccgc gctcgcttca tgcatccatg tcgtttcata atgataattg 2982961 tgtttattta caagcgtaat gtcagcatca ttcggcccga catacttcgt cagccttgtc 2983021 accgtcatca atccgccata tcctgcacct aaaatcacga ttttgggctt attcaatgcc 2983081 atcacatcca ccttctcttt ttttgctttt gttagaccca taataaaatc atcatttgtg 2983141 ttagcttcag cttattggcg ggattttatg aaatatattg aaaagttttt tgtgaagtcc 2983201 ttacccgtag cactattatc atgtttatcc ggctggccca agaaacattc agaaaaagat 2983261 catttcattt ggttattatc gtagcggcct gcggaaatat tttcaagaac ggatgggcac 2983321 gttagatcct tacgattttt tctgctgact cgtcaatttg aacggcaata tggtataatt 2983381 aataacaatt ttcatttagg aggcaatttt cgtatgcgag aggatacaaa ggtttatgat 2983441 attacaatta taggcggggg accggtcggc ttattcaccg ctttttacgg cgggatgaga 2983501 caggcaagcg tcaaaattat cgaaagcctg cctcagctcg gcggacagct tagcgcccta 2983561 taccctgaga agtatatata tgatgtagcg ggattcccga aaatccgcgc gcaagagctt 2983621 atcaataacc taaaagagca aatggcgaaa ttcgaccaaa ccatttgtct ggagcaagcg 2983681 gttgaatctg ttgagaaaca agcggacggc gtgtttaagc ttgtaacaaa tgaagaaacc 2983741 cactactcta aaacggtcat cataactgca ggaaacggcg cattcaaacc gagaaagctg 2983801 gaacttgaaa atgccgagca gtatgaaggc aaaaacctcc attacttcgt tgatgatctg 2983861 caaaaattcg ccggcagacg cgttgcgatc cttggcggtg gagattccgc ggttgactgg 2983921 gcgcttatgc ttgagccaat cgcaaaagaa gtatcgatca ttcaccgccg cgacaagttc 2983981 cgagcgcacg agcacagtgt ggaaaacctt catgcgtcga aggttaatgt cctgacacca 2984041 ttcgtccctg cggagctgat cggcgaagac aaaatcgaac agctagtgct tgaagaagtg 2984101 aaaggcgacc gcaaagagat tttagaaatt gatgacttaa tcgtcaacta cggtttcgtt 2984161 tcatctcttg gaccgatcaa aaactggggc ctggacatcg agaaaaattc cattgtcgtg 2984221 aaatcaacaa tggaaacaaa tatcgaaggc ttctttgcag caggtgacat ttgtacatac 2984281 gaaggaaaag tcaacctgat tgccagcggc ttcggcgagg caccgacagc agtgaacaac 2984341 gccaaggctt acatggaccc gaaagcccgc gtacagcctc ttcactcaac aagtcttttt 2984401 gaaaataaat aataaaaaaa ggagcttgtg tctgcgacac agctcctttt ttatttgaag 2984461 atatttatat aattcaatgc agttcctaca accagcgcaa tcacaagggc tgcgactacc 2984521 cagatcattg ccataataat gcggtcctga atcttttggg acttcggtgt tttttcttcg 2984581 ttttgggcca tcttattcgc tcctttccca tgtccatgcc ataaagaaag cctggtgctg 2984641 aacgaccaag ctttgctgaa cgtatatcat tcgcgttttg atccgctctc taagaccatt 2984701 cgttaaaact atgataccta aactcaccct gcatgacaag cttcggcact tgcaccacac 2984761 ctgccagcaa atcataatgt ttgacatcct aaataaaaca gagtacatta tataaggcga 2984821 acatttcata tattatactt ttaaatattc gtttttagga gtgaaaacca tggaaaacgt 2984881 atttgattac gaagatattc agctaattcc tgcaaaatgc attgtgaata gccgttcaga 2984941 atgtgataca tccgtacgtt taggcggaca tacatttaaa ttgcccgtcg tccctgccaa 2985001 tatgcagacg attatagatg aaaaactagc gatttcatta gccgaaaatg gctactttta 2985061 tgtgatgcac cgatttgagc ctgagacacg aattgatttt attaaagata tgaacgcacg 2985121 cgggttattc tcttctatca gcgtgggcgt caaagatgag gagtatgaat ttgtccgcca 2985181 gctggcagaa gaaaatctga ctcctgaata cgtgacaatt gacattgctc acgggcactc 2985241 aaatgctgtc attgaaatga tccagcacct taaaaaacat ttgccggaca gctttgttat 2985301 tgctggcaat gtcggaacgc cggaagcggt cagagagctt gaaaatgcgg gagcggatgc 2985361 cactaaagtc ggcatcggac cgggaaaagt atgtattacg aaaatcaaaa caggcttcgg 2985421 cacaggcggc tggcaattag cagcgctgcg ctggtgtgcc aaggctgcca gcaaaccgat 2985481 tatcgcggat ggcggcatcc gcacccatgg cgacatcgca aaatcaatcc gattcggcgc 2985541 aacgatggtc atgatcggtt cactatttgc cggacacgaa gaatcgccag gccaaacgat 2985601 cgaaaaagac ggaaagcttt acaaggagta cttcggctca gcctctgaat tccaaaaagg 2985661 cgaaaagaaa aatgtcgaag gcaaaaaaat gcacgtggcg cataaaggct caatcaagga 2985721 tacactgatt gaaatggagc aggatcttca atcttctatt tcttatgcag gcggaacaaa 2985781 gcttaacgcc atccgcaatg tggattatgt gattgtgaag aattccattt ttaatgggga 2985841 taaatattaa tcataaaaaa acgccaagtc agcggttctc cgcttgagtt ggcgttttct 2985901 gctacttctt cagcaaagta agcttatatt tgctttttga gtttatcttc catcagttct 2985961 gccatttgtt ttgcatttgg attttcttca ttttgcaact gttcaatgac gttcatataa 2986021 tccgtttcat ttcggttctg gcttaattta tatgccgctt gaatgtcttc caccttaatc 2986081 ttaaatccaa caataccttt caattcactt tctaagagtt ttggagaaag cttatcccat 2986141 aacacaggat tgtcacgatg tttttcgtat ttctccaaca tgattgttaa ttcttctgct 2986201 aattcatctt tctctaacat acttgctttt ccatacatgt ggacagcctg ataattccac 2986261 gtcggaacat tttcgcgcga ataccaggaa gaagaaatat aagcgtgcgg tccctgaaac 2986321 atcacaagca catcttcaca ggcttcaaac gttctccact gaggatttcc ataagcgaaa 2986381 tgccccgtaa tatagtaatg atcgtctttt ttattgaatc ctaacggcaa atgtgtggca 2986441 attggttttc cttgttctgt tgtgacaacc gtaccaaagg agttttcttg tacaaaattc 2986501 caaatttctt cagcatttgt gactttaaaa tattttggaa tatacatcat catccaccct 2986561 tcgaaaaata ttatatgagt gttttagcca tgattaaatc cgtttgttct tcatcaccca 2986621 tataaaatga gtgggcgccg gtctgaacaa accccatttt cttataaaag gcaatggcat 2986681 tttcattttt ttcccacaca cctagccaaa tgttcttttt attacgttcc agcgcaattt 2986741 ctatcgcttt attcagcaga tgtttgccaa gcccatgttt ttgaaagctg ttctttatat 2986801 aaattctctc gatttcaagt gattcagcac ccatttcttc agactgagca tcatcgatat 2986861 tgacctttac atatccagcg atttcatgat caaagtaaat aaaaaagaat tgcgaagaca 2986921 tattagataa ctctttttcc agctgctcag tgttaaatgc gctttctaaa taggctttca 2986981 tattttcagg tgagttctgt tctttaaaag tgtcattgaa tgtttcaata ctcaattgtt 2987041 gaagtgtttg taaatcttcc cggctgcatt ttttcatttt tacactcatt gttcggattc 2987101 agccccttta tttaaaattc aattgtcttg tgtccctttt atatatttaa acacggaaca 2987161 catactgacc ttgttaccat tccaaaaatc ttcttcatca ccaactccct atcgtgattt 2987221 tgttgtaaat gcaataaaat atactccgca ttaaatatat cgtaactttg ctgtatttac 2987281 aacaaaaatc aaacaacaaa gcagcgtttc tcttgccgaa gttcccggaa ctctctgcat 2987341 catttcccca taataaaaac gcctccctta acgatgattt atcgctaaga aaagcgtcag 2987401 taatagttgc tatccgtttt tagtgcttag cactcttcag gcttgcctgc attcgttgct 2987461 gttctgaacg aagaaccgca gccgcatgaa gcgatggcgt ttggattgtc gatggtgaag 2987521 ccgccgccga gcatggattg tttataatca atcacggtgc cgttcatgat gtcaaggctt 2987581 tctttgtcaa ctagaacagt gatgccgtgc tgatcaaaca cactgtctga ttcactcttt 2987641 tcatgctcaa agcccatgcc gtaagaaagt ccgctgcagc cgccgccttt gacgcctaca 2987701 cgcagaaacg cgttttcttc ttcatgctct ttcatcatat cttttatatg caaagctgct 2987761 gcttctgtaa ttgttaccgg gttgctcatc attatgaacc tccttttaaa aaccggttgc 2987821 tgtcttttat tataaacatg atcgttccaa ttctcaaaca aggtgtttta caagaaatag 2987881 acaccctcac aaacggtttc agccggccct gtcatcatta catggccgtt atctttccag 2987941 tttatcacca aatccccgcc tgctaaatgc accgtgatgt cttgatttcg ctttgatacg 2988001 ccgtttaata cagatgcgac tgccgctgca catgctcctg tcccgcatgc ctgagtaatc 2988061 cctgatcccc gttcccagac gcggaaatgc aattcttgtt cattcacggt ttcaacgaat 2988121 tccacattga tgccttccgg aaatctcgga tctttctcaa tcaccggccc cagtgtcgtt 2988181 aagggtgcct gttcaatgtc tgcgatcgga aaaacgatat gcggatttcc cattgaaacg 2988241 gcagtgcctg ttagttctac ttcaccaaat gccatcgttt cattgattgt gtgctcttcc 2988301 ccgccgtcaa gcataggaag ctcggatttt gtcaagcgcg gttcgcccat atcgacagtg 2988361 accacattca cttttccgtt ttcgacttga acctccgctt tcacaagccc ggagagagtt 2988421 tcaatcagaa aagatgtttc ctcaaccagc ttatgctcat atgcgtattt tgcgacgcag 2988481 cgcaggccgt tgccgcagtt tttcccttca gacccgtcat tattaaaaat ccgcatttta 2988541 acaggcgctt ggtctgatgg gcatatcagg atcattccgt cggatccgat ccctgtataa 2988601 acagaagaaa cctgaattgc aatctctgac agtttttctt ctggaagctg ttcttcaaat 2988661 tgattcacat aaatataact gtttcccagg ccgtgcattt tggtaaatcg aaatgagttc 2988721 ataggtgcct ccaacttttt ttctttttct tagtataaaa gctattataa gcggacacaa 2988781 tacaattatc ccccgttttt catacataaa agctccttgc actgacgcaa ggagctttta 2988841 tcgtttatat aaacatgccg gcaatggctg cgctgagcag attggctaat gttcctgcaa 2988901 gaacagcctt caggccgaga cgtgcgatat ctgaacggcg gctgggcgct aaaccgccaa 2988961 gcgtaccaag cataatcgca attgatgaaa aattggcgaa tccgcataac gcgaaactga 2989021 taatggtagc agttttctta gaaaactcgc cgatgtgcga accgaagtta gaataagcga 2989081 caaactcatt cagcaccaat ttctggccga tatagcttcc cgcctgcaat gcttcatgcc 2989141 aaggcacgcc aatcaaaaag gcgataggag aaaacacata gccgagaatg gattctaatg 2989201 ttacgccttt taaaccgaac aagccgaaag ccccgccgag aataccgttt actacagcga 2989261 ttaacgcaac aaacgcaagc agcatcgccc caacatttaa cgcaatttgc agtcctgttg 2989321 acgctccctt tgcagctgcg tcaatgacat tggctgcgcc ttcgccttca tccattttga 2989381 aatcgctttt tacggtttgc gttttttccg tttcgggtat aatcaattta ccaaagacta 2989441 gtccagctgg agcagccata aagctggccg ccagcaagta ctcaatcgga ataccgagaa 2989501 gcgcgtaccc aaacaaggta gatcccgcaa ctgccgatag accgctcgtc ataatcgtaa 2989561 acaactcaga gcgcgtcagc ccggcaatca ggggtttgat cactaacgga gattctgatt 2989621 gtcctacaaa aatattggca gcagccgcca gagattccgt tttgcttgtt ccaaggagct 2989681 tcgacaatcc gccgccaatg acacggaaaa cgagctgcat gattttcaaa tgatataaaa 2989741 ctgcaatcag tgctgagaag aaaatgataa cgggcagtac acttaatgca aatgccggac 2989801 tgtctccgac ctttagaagc ggtccaaaaa taaaactgat gccttcattc gcatagtcaa 2989861 tcagaagctg tacacggctt gaaaaccata aaaaaacagc gcgtcccgct tcccatttca 2989921 acacgatgta tccaaacgcc acctgtgtgc ataaaccaac gatgacggtt cttatcttaa 2989981 tattgctttt cttttctgaa aataaaaacg cgatagcaat gatcgcaact gcgcccagca 2990041 gcccccacag aacattcatg aatactcgta cacctcttaa attttattta aaaaaatatc 2990101 ttttatacga taacaataat attttttgat gtctacacat ttttttagtt cttttgtacg 2990161 gcaaaataaa aaagggcctg tccaggccct tttctttaaa acattggatt ttcttcaata 2990221 aaggtatata tattctcaac aagctcagca ggcgtttcac ccatgacgac ttctccgttt 2990281 accagagcga aaagcgattc catacatgtc ccgcagtagc ttaagcagcc atattcaagg 2990341 acatcaaggt tgggatcctt ctccaaaatc gcccgggctt cctgagagcc gtgagccaga 2990401 ttgctgacac aaaattcaat cattggattc atgcggtttc acctcacata tgtccattat 2990461 cgcgaatttt tcactattcg tcaaagacaa cggatgattc aaaatttatt atcgtaacat 2990521 attatttctc aaataacgtt ttactaattt gtgttttcag gctaaattgt aggttatttt 2990581 gaaactatta ttgtgatttt agatcaaatt cgatataatt ctagatgtta ttttacatag 2990641 ttcgtatttt cttcaatgta tctatcatac tcttcggatt aaaggggaat tcaaatgaaa 2990701 aaattggtct tgatcggcgg aggttacggg aacatgcgcg ttcttcatcg cttattgcca 2990761 aaccagctgc ctgatgatgt ttcaatcacg ttaattgaca gaaatcctta tcactgcttg 2990821 aaaacagaat attatgccct tgccgcaggc acaatttctg accatcatat cagagtgtca 2990881 ttcccagagc accctcgcct ggatgtccaa tacggtgata tcacatcaat tgatattgta 2990941 caaaaacaag tgctgttcca agatcgtgaa ccgatttctt acgatgacgc cataatcggg 2991001 ctcggctgtg aggataaata tcacaacgtg ccgggagcgc ctgaattcac ctacagtatt 2991061 caaaccatcg atcagtcccg cgaaacctac caaaagctga ataatctgag cgctaatgcc 2991121 accgtcgcca ttgtcggagc gggcttaagc ggcgttgagc ttgcaagtga attgagagaa 2991181 agccgtgatg acctgaacat tattttgttc gaccgcggta atctcatttt atcaagcttt 2991241 cccgagcgtt taagcaaata tgtgcaaaaa tggttcgaag agcacggtgt ccgcattatt 2991301 aacagggcaa atatcacaaa agtagaagaa ggcgttgtgt ataaccacga tgatccgatt 2991361 tctgcagacg ccatcgtgtg gacagccggc atccagccaa acaaagtcgt cagagactta 2991421 gatgtggaga aggacgcaca agggcgtatt gtattaacgc ctcatcataa tcttccaggt 2991481 gatgaacatc tgtacgttgt cggcgattgc gccagtcttc ctcatgcacc gagcgcccag 2991541 ctggcagagg ctcaagcaga gcagattgtc caaatcttgc aaaaacgctg gaatggagaa 2991601 gccctgcctg aatcaatgcc gcagtttaag ctgaaaggcg tcctcggttc actcggaaaa 2991661 aaagccggct tcgggcttgt tgctgaccgt ccgctgatcg gccgtgttcc gcgtatgctg 2991721 aaatccggct tgctgtggat gtataaacac cataacggtt aatgatagag aagaaccgct 2991781 gatcaagtca gcggttttct gtatacccat gcttctccat ttcctcataa acgtctttta 2991841 attttggatt gccttcaccg acaattttgt cttctacaag cacaagcgga taaaaatact 2991901 cgtcatttct gattttttcc gcaagctctt tcgcatgttc attgtcaggc ggctcatgaa 2991961 tatcgatgta ctgcatctca aaaggctgat ttggatattt tcttttcagc gcagcctcaa 2992021 gccactcgta tgtatccttg gctgtcggca tatttacaca gctcgcacaa acgttttctg 2992081 ccccgtacac gcttagcatg actggtttca tcacttgtag acgccccctt ctcctatgta 2992141 agtcctttct tttaagtata cagagcctaa gggcgttttt atagaaaaaa accgtttttg 2992201 tgttgaagtc tgaatgtgct ataataggga aagcaacttt gcaaaccaaa caatagattt 2992261 ttattgttac actgaatata atggttttat gacgacgaaa ggagcgaatg tcatgactga 2992321 agttgaaatg aaagaacagg tgcaggaagt actggacaaa cttcgtccgt ttttacttcg 2992381 tgacggcggt gactgtgagc ttgtagacgt agatgaaggt atcgttaagc ttcgtcttct 2992441 aggcgcatgc ggcagctgcc caagttcaac aattacgttg aaagccggaa ttgagcgcgc 2992501 tcttcttgaa gaagtgccgg gtgtcgttga agtagaacaa gtcttttaat aaagcagcca 2992561 ggctgatatt tgatcagcct ggctttttta ttagagatgt tgatcaaacc atgagctgat 2992621 ataattcagg cgcttgatcc gctgtcttgg gtgtccggtg cgtgataaat tgtgcgatgc 2992681 attcggaaaa cggacaagct tggtttcctt gcccattttt ttcagagcga taaacagctg 2992741 ctccgcctgc tcgatcgggc atcggtcatc ccgctcgcca tgcagtatca aaagcggtgt 2992801 ctccacgttt gctgcgtatt ttaaaggaga ccggtcccag agcttttctg tgtcctcaaa 2992861 catgtcatgc tcaagctgcc agtctgtaaa gaaatagccg atatcactga cgccgtgaaa 2992921 gctgatccaa tttgatatcg agcgctgggt aacggcagct ttaaagcggt tcgtctgccc 2992981 gacgatccag ttggtcataa aacctccgta gcttccgccc gtgacaccga gccgcttagg 2993041 atcaatatgc ggatctcgtt tgatagcctc atccacagcc tgcatcacat cgtcataatc 2993101 ctttccccca taatctcctc tgaccgcatt cacaaattcc tgcccgtagc cgtggcttcc 2993161 tctcggattg atataaacga ccgcgtatcc tttcgccgcc agcacctgaa actcatgaaa 2993221 atatgtatgt ccgtacatca tatgcggacc gccgtgtatg ttaagaataa gtggatatgt 2993281 tgtctcacct tccatttgtg caggcctcat cagccagccg ttcaccatca cgccgtcttc 2993341 tgtagcatat tgaatctctt caggtattga tatcgtatgc tccctgacaa acttgtcatt 2993401 cgcgccagtc agctgtttct cttcctgtcc aagcgggata ctgtaaagct cactcggtct 2993461 gtccggcttt gtcacactgg caataaagtg ctgttcatca ggtgaaagag aaaagctatt 2993521 gatgtactct ttttccagac gaatcggata cacaaggcct tcaatcgaaa tataatagat 2993581 gcccgtactg ccttgatctg tgccgatgac ataaaaccct tggctgtcct ttgtccaaat 2993641 cgggcgctgt tcagcaccac cgatcaatga atctccaatc agcgcatccg ctaaatgaac 2993701 gtccagcatc tcagtaagac atgtgaggcg gccttgttcg atatcataga gccacgcctt 2993761 tgagagcgta gcattcttat attccttttc atttccaagc aaagcaagat accttccgtc 2993821 tggtgaaaat gagcttgatc cgaatgagcc gcgatgaggt gtaacctgct taagatctcc 2993881 agactccagt gacattatgt aaacatcatg cggcttgctg gcatcatctg tttcagttaa 2993941 attagctgag aaaacaagcc atttgccgtc aggagaaaaa gcaggatcac catgatcagc 2994001 tttgtgactt gtcagctctt tcatctcacc cgactttacg ctgacaagca caagctgggc 2994061 atacgcacct ctcgtcagcc ctttgccgtc ccgtttgtag gagaggcctt gcacttcaac 2994121 aggttcatag ctgtcctgct ctgttttttc tcggtcatca atgctttccc cctctcccaa 2994181 actgacagtg accagaatcg attcaccgtc cggggaccat agcggctttg acacgccata 2994241 tgggatatca gtcagttttc ttgcttctcc gccttcagtg ctcatgatat aaagctgtgc 2994301 cgcatcgcct tctcgatcag aaataaaggc aagcgtgcgc ccgtccggag accatcttgg 2994361 gtcggtgctt cgcttttctc catgtgtcca aggaacagat cctcccgttt tcgtttcata 2994421 gatccatata tttgatgtat acgaatcttt ctcttgattt acttgtgatt ttacatatgc 2994481 ggcacgggta ccgtctgggg cgtattgagg atcggtcaca gagacaatcg ctgtgatgtc 2994541 gtctgcggtt atcagctttt tcatattcat ctcctccttt ttacatgtat ttcgtttttc 2994601 taaataaaaa ctcctttatc tccagcaaaa aaaagcgccc tccgctgacg ctgaggaacg 2994661 cttggcatga tctatacact ttttacttga tataaaggat ttcgctctat tatacttccc 2994721 tctttcggaa cggtcaaagc gtctacttca caatgaggga aatgaagcgc gagctgttct 2994781 tttagctctt ctccctttcc tttttcggtc atgacgagaa tcgttgggcc tgctccgctg 2994841 agagccgttc catatgcgcc cttcatctcg gcgacgtgct ctacttttga cagctcaggc 2994901 acaagcatcg cccggtacgg ctgatggaac atatccttct tcatgatttt cccgacaagc 2994961 ggccaatcct tggacatgat cgcagcaatg aggatattgc tgacagcact tgcttttacg 2995021 gcatcggcat atggaaactc cttcggaagc acgtctctcg cgtctcttgt cagcacttca 2995081 taaaaaggaa tgacaacgac tacgtcaatg tcagcattcg ggacgcggat catttgggtc 2995141 tcgtcatcct catgcaggcc gatcacaagt ccgccgacga gagaagcgcc agcattgtcc 2995201 gggtgtcctt cttctagact cgctaaatgc agcttgtccg cttcagacag ctttaagccg 2995261 cataattcat cagccagttc aatggccgct acaatcgctg cggcgctgct gccaaggccg 2995321 cgtgcaagcg ggatgtcgct ccacaccttc acatggacag gaggcatttc ttttccgtac 2995381 aaatctgcgg tccgtttagc cacttggtag atcaggttat ctgtacccgc cggaattccg 2995441 gcgactgttt ctgtttcagc ctcaaaagac catttgtcgc tttcaaagac ggtcagcttc 2995501 aaatatctgc tgagcgccat tccgactgaa tcaaagccgg ggcctaggtt agctgtgctt 2995561 ccgggaacag tgacagagaa cagcatgtcg gcttcgttca tacacgggcc gctcctttta 2995621 catattcaag gatgctgtct tcatcagtcg gcaatgtgac aggcttgatt tctgaaatgt 2995681 cgaccgctgt gttcggatct ttcagtccgt ttcctgttaa cacagctacg accttgctgc 2995741 ctttcggaat ttctccggat ttcacctgtt tcagcactcc tgcgatagac gcgcaagaac 2995801 ctggttctgc aaacacgcct tctacacggg cgatcagctg atatgcgtga aggatttcat 2995861 catcagtgac ttcgtcaatt ttcccattgg attcctcggc tgcctttaca gctttgtccc 2995921 agcttgccgg gtttccgata cgaatggctg tcgctattgt ttccggattt tcaatcactt 2995981 cattgcgcac gattgccgcc gcaccctcag cttcaaagcc gcgcattttc ggaaggcctg 2996041 tgccgttttt ctcatgatat tccttgaagc ccttccagta cgcagtgatg tttccagcat 2996101 ttccgaccgg gatcgctaaa acatcaggcg cttcccccag ctgttcgcac acttcgaagg 2996161 cagcagtttt ttggccttca atgcggtaag ggttgactga gttgacaagg gcaatcggtg 2996221 atttctcaca gatggaacgg acaattttaa gcgcatcgtc aaagtttccg tcaattgcga 2996281 taatctcggc tccgtacatg acagcttgag cgagttttcc aaatgcaatt tttccgttcg 2996341 ggatgatgac aatgcatttc atgttagcac gggctgcata tgctgccgca gcagcggaag 2996401 tgttacctgt tgacgcgcac ataatcgtgt cattgccttc ttcttttgcc tttgccacag 2996461 ccataaccat tccgcgatct ttaaatgatc ccgtaggatt gacgccttcc gttttgacat 2996521 gaagctcaat tccgagctgc tcagacagct tcggcaggtg aataagaggt gtgtttcctt 2996581 catgtaaagt tagcgccggt gtttgatctg ttacaggtaa aaattcttta tattgatgga 2996641 taagtccttt ccacattagc tccaaccgtt cccttctaca cgatatgtgc ttttgacttc 2996701 ttgaacgact tccaaatcat ttaggttttg caggatatca ctgaaatcag cttctgatgt 2996761 atgatgtgtg acaattacga tttcagctaa ctcatcatgg cctttaattg gcagctgaag 2996821 gattttttca aagctcacgc cccgctctga gaacacagat gtaattttcg agaatgaacc 2996881 aacctcatct tttacatgaa ttcttaaaaa ctgctgtgca taaatgtcag acggcgattt 2996941 catgtttttc tcatattgcg gtccgacaaa gctgttgccg gttacaccta ggcgcatatt 2997001 tttcatgaca gcgacgaggt cagaaacaac ggatgtcgct gtcggcatgc ttccggctcc 2997061 cggcccgtag aacatcgtct caccgacagc ctcgccgtat acataaacag cgttaaactc 2997121 attatgaaca gcagaaagcg gatgatggtc aggaagcagt gtcggctgta cgctgacctc 2997181 gattttgctg ccgtcacgct gagcaatccc gatcagcttc attgtatagc cgaggcgttt 2997241 gctgaagctg atgtcctcgt ctgtaatttg ggagatcccc tttactttga cgtcttccag 2997301 atccacgttc atcgagaagc cgaggcgcgc caatatcgcc attttccgtg cggcgtcaag 2997361 cccttccacg tcagaagtcg gatcagcttc ggcaaaaccg agatcctgcg cttccttgag 2997421 cacttcctcg tatgggcttt tctctttgat cattttggtt aagataaagt ttgttgtgcc 2997481 gttcacaatt cccatcattt ttgtaattcg atctgatgag aggccttcct ctaacgtgcg 2997541 cagaatcgga atcccgccgg caacactggc ttcaaagtag atatcgcatc cattttcctt 2997601 cgcttcggca agcagctcgg agccgtacac agccattaag tccttgtttg ctgtgacaac 2997661 atgctttttc gatctcagcg cgtcgaccaa atattgtttt gtctgttcaa cgccgccgat 2997721 cacctcgatg acgacatcaa catctggatc atcaatgaca tcatacactt ctgtcgtgag 2997781 cacttccttc ggcaaatcta cttctctctt tttctctaaa tcttttacaa gcactttttt 2997841 tatcgtaacc ggacagccga cctgatgcat aagcttatcc tgatggtctt gaataatttt 2997901 aacgacaccg cttccgacgg tacctaaacc taaaagccct acacgaatcg ctttcaaaaa 2997961 aactccacct ttcttttgat tgtcctcttg gaaaagacaa ttgttaactc aacacagaca 2998021 tataagttac aaacattata taagcccgct cctgttttga caagacatca ttaggctgaa 2998081 ttttgcgaat gtaaacgctt aacgcattga tatgacaaga ttctttattt tctaattatt 2998141 tttgtcagat tttctcctca ccttgagctg cctttgccga gccagctgac gcgtggaaca 2998201 aacagcttct gcgcccgcat attcatgaat tcctgcgctg tattgagaaa ttgttcataa 2998261 cgcccacagt cattaagaat gaagtcaagc tgttcttcaa aataatgctt ttctgattct 2998321 gatgacatgt aatagctttc tacgatttca aaataatgaa gcgggaaaag cagacggctg 2998381 tataaaaggc gtttcgaaaa tgaagacagc ggtgtgactt gctcgtattc ctgtaaaaag 2998441 agaaagccct gctgattaaa atcttgtctg tgatgcaaaa acgtatgcct catatattca 2998501 gccaaatcac gggaagcgtg gtcaaacacc caatccgccg gaatcctgat caatgattcc 2998561 ggtgaccatg tatgcctttc catccgctga tggcatatcg ttcctgaatc agcggcttgg 2998621 ggcttgtcat ccagctcagt gtccactaaa tattgtatcg cgttttctga cagtcctaaa 2998681 taatatggaa atgattcgat cattttttta tcgaatggct catgcggagg ggtctgaacc 2998741 tttctctgcc aaaatgcttc cagctgatca attcgttttc cccacagatc cttccactgg 2998801 ccgattcttc cggccgcctt cacctcatat ggatatcctc ggccttttcg gtgaaattcc 2998861 gcaagctccg ctccaatgga gaacgccctg tttgaataag ggggggccgc cttcagcaga 2998921 gcgtacgttt ttccctcatg ttcaaatgtc agttcacctt cttttgtaaa gataaaaacc 2998981 gaaacgtatg ggtcactttg ttcttgtaaa tactgactca tgtaataaag ctccgccagc 2999041 tctgtttctg agaattggga aacggggaca atcagaaagt atgaattagg cgtctgaaag 2999101 cattgatatg tgtgctggta catggaaagc tgcctgatgt gaatgccgta tttttctttt 2999161 attgtacctt tcaccatgat cacctgcctg ttgaattagg gctcatcaca tcgtagtcat 2999221 acacagccgg aattatgaat acatatttta atccgaagaa ggcgcaagaa aaagtcgtaa 2999281 acttctcaag cattttgtat aaactagtaa aaaagattgg gtgaagctga tgtcagaaaa 2999341 cgaacaattc agtcagatgg aagctaaagc aagagcacgg atgaaggagc gcggcgttga 2999401 ggtatcagac attgccgagc ttgtcttttt tctgcagaaa aaatatcatc cggatttaac 2999461 cattgatgaa tgcacgctga acgtcaatcg tgttctcgca aaacgcgagg tgcaaaacgc 2999521 gattttaacg ggcattgaat tggatgttct tgctgagcag aaaaaattgt ctgaaccgct 2999581 gcaaacgatg ctggaaatag atgaaagcct atatggagta gatgaagttc tggcattttc 2999641 cattgtgaac atttacggat cgatcgggtt tacgaactac ggttacatcg acaaagaaaa 2999701 acccggaatc cttaaacgat tgaatgataa atcaaccggt gaatgccata cctttttaga 2999761 tgacatcgtc ggagcgattt ccgccgcggc ttcaagcaga cttgctcacc gcgcgcggca 2999821 tacagaataa gggcaccctt ttagggcgcc cttttttcaa atgtatggaa tccattcagt 2999881 cagagagtca atggcgtgag tcggtttttc catatcgtct gtcatatgtt ctcttttcgt 2999941 tacgcctgtg tgaacgagca gcgtatccat acccgcgtta atgccggcca taatatcagt 3000001 ggcgtagttg tcgccgacca tgagtgtttc agacacatct gtgccgagaa cgcgcatcgc 3000061 ctgctccata ataattgatt ccggcttgcc gataaataca ggctgtacac ctgtagatac 3000121 ggttaacacc gatgtcagtg agccgtttcc cggcaggagc cctctttcag tcggaatcgc 3000181 aatatctccg ttagtggaaa taaagcgggc gccatttctg attgccaggc agccaacagc 3000241 aaatttttcg tatgtaatgg aacggtcgat gccaacaacg acaaaatccg cgttttctcc 3000301 gccaaatgtc aggccgtttt cttcaatcgc ctggcggatt ccttcctccc caatcacata 3000361 cacagacgcg tcttttttct gctgtgcaat gtgctgggca gttgccatgc tggtcgtgaa 3000421 gacctgctct tctgttgccg gaatatcaaa agacacgagc ttgtccgcta cctgcttcgg 3000481 tgtgcgcgaa gagttgtttg tcacgaaaag ataaggaacg ccgcgatctt tcagcgttct 3000541 gacaaattca cacgcctcct cgattttttc cgtgccattg tacatcgttc cgtctaaatc 3000601 aattaaatac cctttatatg ttttcatatc caacactcct gtggctttcc agttgttatt 3000661 taaacgcgga aacaggtcct agctctgttt ccaaatagct tctgatccgt ttcgggaagt 3000721 cctgaagagc tgtttgatgc gccttgatca gcctgtaaag ctcgccgctg tcagcgagca 3000781 gatactgttg aaccaacgtt ttgcggtagg cgatcaattt tttgagctca tcaccctctt 3000841 tttccgtgac aactttctca tcaacaagta tatccataat gtcgtcatag ctgcccgggt 3000901 cccgcataat aaagccgtca atcatgtcat tgcctgtatc caaaatgcat tcgattaaca 3000961 gatggcctat acgctgaagt gccaattccc cgatttcaga ctgccagtct gtttgtgagt 3001021 caaatagcgc cagctggtgc tcgaagaacc ctagtgtttt ttcgattttg cttctgtcaa 3001081 caaaatacat gacagcatcc cctttgtgta tatttatttt ctgatccgtt tcaagacaaa 3001141 atacgcacag ccgaaattgc agtattcgta aatatattca tctaatgtgc tgattttcgt 3001201 ttcgaaggtt gccttttgat tctggtcgtc aaagaagccc ttgagcctta actgaccgta 3001261 tccccagtct cccacaatat aatcgtattt atttaatata tcggagtagc gggctttaaa 3001321 agcctcttcg ttgaagccgt ctttgaaatt gtgcaccaat tcaaattcgg cattttgaat 3001381 aagaatcatg atctcacctc ttttttcact cattcctatc ataattcatt gccccgtccc 3001441 catcaattgc taaagaataa atcatgcgat ttggctaccc tacacatgag gagggattga 3001501 taaatgaaac gaaccgctgt cagcctctgc ctgctgaccg gactattatc cgggtgcgga 3001561 ggcgcaggat tggataatgc ccaaaatgtc cggaatcaga cgcagaatca aaccaaaccc 3001621 attcatgtgt cggaccgcaa cgaggctttt aacaggcata atgagaacga acaatttggc 3001681 tatgtccgct atcaaaaaga acaatttgac ggagaacagc agaaaacgcc ggtgatgaac 3001741 cgggaagaaa ccgctcacat gatatcaagt ttaacggttc agctccccca tattcaagat 3001801 gctgcgacat tggtgactga ccgagaagcg cttgtcgtat acaaaaccga ttctaaaaac 3001861 cgggagctga ccgccgatca ggtgaaaaaa acagcggctt ctgtgatacc gcgatactat 3001921 cacgtgtata tttccgataa tccaaaccat atgcaatccg tcgaaaatta cagcaatctc 3001981 ggctctggtt caagggatat tagagagatc atgtcgggga cgattcaaga aatgaaaacc 3002041 tccccgcaag gaagccctgt ctcagagaat gaaaatgcca atggagaaac gcgtcaggac 3002101 atgaaaatcg ataggaatga caaaaacgcc agatgatctg gcgttttggc attatgcttg 3002161 tgcttgacgc tttttagatg cttcgtttac ttgttcatcc gcatggtaag aggaacggac 3002221 aagcggaccg gcttcacaat ggctgaagcc tttttgcatc gcgatttctt ttaattctgc 3002281 aaattcatca ggatggtagt atttttggac tttcaagtgt ttcttcgtcg gctgcagata 3002341 ttggccgatt gccataatat ccacgttgtt cgccaagagg tcgtccatta cttcaataat 3002401 ctcttctttt gtttcgccga gtccgatcat gatacttgat tttgtcggaa tgtcaggctg 3002461 catttccttc gcacggcgca aaaattccaa tgaacggtcg tacgtcgcac gcgcgcggac 3002521 tcttggcgtc aggcggcgaa ccgtttcgat attgtgattc aggatgtctg ggcgtgtatc 3002581 catcaaggtt tttaggttat cgtagtttcc gcccatatca gacggcagca cctcaattgt 3002641 tgtgaacggg ctttttctgc ggatcgcacg gacagtttcc gcgaaaatgc ctgccccgcc 3002701 atctttctga tcgtcacgcg caacagccgt aatgaccgcg tgtttcaaat tcataagcgc 3002761 gactgaatcc gctacgcgtt ccggctcttg cagatcaagc tcagttggaa ggcctgtttt 3002821 gacagcacag aaacggcatg ctcttgtaca aacagaacct aaaatcataa atgtcgctgt 3002881 acgtctgacc gcccagcatt catgaatatt cggacacttt gcttcttcgc atacggtatg 3002941 caggttgttt tcccgcatga gttttttgag ccctgtatag ttttcatttg tatttaattt 3003001 aattttaagc cattcgggct ttctgaggtg ttcgtctttc tttgccaatt cccatcatct 3003061 ccaatatcca atatactcaa tttctgacac gaaacattct gaaaacgaga aaggtgcagg 3003121 ttttagttct gcaacaaaaa taatgttttt ctaactaaag aaagtctttt ctttagacac 3003181 tttaacatag gaaaaatttc tcgacaaggg aagatgatta ctgacatttt taagccgggt 3003241 tgccgcaaac tatgtgtatt caatatgaaa ggagattatt ttgtgaaagt tttgttatcc 3003301 gctcttcttc tccttttgtt tgcatttgag ccttctgcgt ctggaaaaaa actttcagat 3003361 ccagtgctgt cgaaacggat ggaattatat cataaaatcg aagctgtgac gcagatccct 3003421 tggtatgcgc tcgccgctgt tgatcaatac gaagaaaacg tgcggagcaa ccggaaagat 3003481 ctgcctgaaa aggcgggaat catcagcatc tatatacccg atgatatctg gagcgggcct 3003541 gaaaacccga atccgaaaga cgatgcgccg ttaagcatta aagtgtttga cggaatcgga 3003601 atggatggcg atggagacgg gaaagccgag gtcagcaacg atgaagatat cttgtatacg 3003661 ttcagccaat acttactgtc gtatggcaca gatgaagaca acatccggat cgggctttgg 3003721 aattattacc ggcgtgatca gacagtgggg attatatctg aattcatgaa gctgtttaaa 3003781 gcctacggcc atattgatct gggcgagcat gcattcccgc ttccgatcag aaccgattac 3003841 agctaccgaa gcacgtgggg agatgcccgc ggcttcggtg gaaggcggat tcatgaaggt 3003901 acggatatct ttgcccatta cggccttcct gtcaaatcca catgttacgg cgtagttgaa 3003961 atgaagggct ggaaccgctt cggaggatgg agaatcggca tcagggacat taacaatacg 3004021 tatcattatt ttgcccatct caatgggttt gccaaaggga ttaaaacagg acaaatcgtt 3004081 gagcctggcc aagtgatcgg atcagtcggc agctccggat acggcccgcc gggaaccgcc 3004141 gggaagttcc cgccgcatct gcactatggc atgtacaaag ataacggaag aaccgaatgg 3004201 tcatttgatc catacccgca tttgagggcg tgggagcgat atgaatacca aaaaaagaag 3004261 taacaaaaag ccgcctcttc aacaggcggc ttatttgctg cttttttctt tttttgaatc 3004321 ggcaccgttt tctttgctgc tcggaagctg gacagaaggc gtgacacccg agccgccgct 3004381 tccattataa aactgcggca cttcgccctg cactgcttta atcgatacag gaacattatt 3004441 tgtgacgaca gcggttttgc tggcaaatgg aatgatgacc ttcactttaa tttcgacaaa 3004501 gatgctgata tcaataagtg cgttatttat gccatacggc ttgattttgg ttttgacatc 3004561 tgtaaaagcg tcaccgatta aattgaaccg gaccgggatt ttcggcccga ggtttccaag 3004621 aaggctgttg ccggttacct gtcccagcgg aatgttgatc ataatgtttt cactggcgcc 3004681 gctgtgtccg gtatgggttt ccatctcttt caaatgagcc tgaagctgct ttgtcacttt 3004741 tgttttcaca ctgtttacaa cctgtgtatt aaaatcgatt gtcgttaagt ttccgttttc 3004801 atcagaattc atttgaaaca tatctttcat attttcactg tcagacatat agtcctcaat 3004861 cgaatcctgg atcacctctg tcgctatacg cttcgtttcc atctcgccga tgtccattaa 3004921 aacaggtttg atcgagccat tgatcatcca aaggctgacc gttgttgaca ggataaaaaa 3004981 gacaacggac aggagcatca cgtaacggaa aggcaaaggt cctctcttgc gaaaagggcc 3005041 gcgatatctt ggcaagaaaa tcccccctta catatcacaa tgtatgcttg taagagggga 3005101 catagtaata gccggggcca atttatttta tttcatcatt tttaaaagcg cttctctgcc 3005161 gctcatgccg actttgatgc caagatcttc cgcagcgtac gtgacggatt ctaaaggtgc 3005221 gtctaacagc tggtcaatgg tgcggacacc aactgcgcgt cccgccacga tgccgcgctc 3005281 ctttaatttt tcattcagca gcgccacatc aagcgcgccg cacataatgt atccgtgatc 3005341 attggcgacg gccataaaat tcgttttggg aagctttact gtcacagctg taaaaggctg 3005401 tccttctatc atgatcggtg tcaggtttac cacgtcaacc actcccttca ttcatcactt 3005461 tatgatgaag ggcacagctt gttgtgggct gactgcctta ttgtgcaagc ttccaagcaa 3005521 gcagatcccg caaaaattcc ggcataaaat attctttttc tgcagcgtcg cgaatcaacg 3005581 gaaacagttt gccgagcgta aacatatcaa gcaccgcaac ggagtattgt ttatgttttt 3005641 caatatcttc cccgttcagt gtgatccgag tgacgtgggt gatcccgtca tcgagccgtt 3005701 tcgtttctac ctcaacgccg gcatacacca ttttccccat cacttctccg cggaagccga 3005761 gtcctttgat ccggagctgc tccatttgtt cggaagcggc atggacaatg gtttccttca 3005821 gttcttctcc cgtcaggcgg acagccaccg ggttgatcgg atgcggacag atgcggtgca 3005881 gatccagctt tgtcacagga cctgctttta gcggaccgag aatgacacct gaattgacca 3005941 tactgatgtc cgtctcgcac cattccttta aggcgtatgc caaaagcaaa ggcagctctg 3006001 attcttcaaa ccacttcacc tcagcatctt gtgcaagctc tgcaacggca tcggacagtt 3006061 tctcctcggc ttcacgttct ttttcattga gaaacgcttt agtttctgcg gattctcctg 3006121 tccattccgc catgttctgc acagaagccg ttttgctgtt gatgcttcgc tgtacgctgt 3006181 ccaccgtgat ttctacacag ccgacataat gcccgtattt ctcggcgctg gccagcagta 3006241 ccccattaac cacttgtcca tcttcgagca aatgatgggt atgtgattcg aggattacat 3006301 caatctcagg caccgcttca gccactgctt gatcatcaag aatgcctaaa tgtgacagca 3006361 gaacgataat atcagcctgc cctttcactt ccagaatggt ttcctttatg ctttcaaggg 3006421 catccgtaac tgtccatccc agcttgtcat atacaggata atacggcaca gttacaccta 3006481 agaaagcaat ggacataccg tttttcaatg atttgatatg gtaaggcacc gcccaggacg 3006541 gacggtttcc atttttatca aacaggttag agacgatgac aggaaattca gcatgatcat 3006601 ataaggcagc aagctcttca tgcggaagcg taatcccttc gttattgccg atcgccgctc 3006661 catcaatgtg aaggcggttt aagagatcga cattcgcttt tccgaatgtc gcctctgtca 3006721 cgaattgaaa acgatcaaga tgatcgccaa tatcaaaaac gagcgtctct tcgccgtctg 3006781 actgatgctc ttttcttttc tgctcgatat aatctacaat tttcggccag ttttcaaaat 3006841 ggctgtgcaa atcatttgta tgatataagc ggagcttctc cttcataata tctctcccta 3006901 atcgttcagc tgaaaatgcc ttcataaatg agctggcagc cgatcaaaat caatacgatc 3006961 cgcatgatca taacgatcgt tttcgtctgc atttttctgt tgatggcggc gccaagcttt 3007021 ccgccgaacc aagcgccggg cacaagcgcg agggcgtaca gccaattgac gtgcccggaa 3007081 atcatatgtg aaacagaccc tgtcatagaa gacaggaaaa taataaacat ggacgttgcc 3007141 accgcaacct tcggcggaaa cagaaataac agcatcatcg ccggaaccat cagtgatccg 3007201 ccgcctatac cgaaaagtcc gcctaaaaaa ccgacaacaa aggcaatggc aataccgaca 3007261 gaggcctgat atgagtacgt ataaggctca ccggcatcat cctgaaatgt ccggataatt 3007321 cctttgtgcg ctttgttgat tggccgggct ttcgctttca gcattaagga taatgaaatc 3007381 agaatcataa aaatgccaaa ccaaacggaa aacgagtttg aattgaacag ctttgacacg 3007441 taagccccga tcatgctgcc gggacccgaa ccgataaaga aaatgagtcc gctcttataa 3007501 tcaactgttt tatatttaat ataagccaaa gttgaagaaa ggcccgtaaa aataatgacc 3007561 aaaagcgaag ttccaatcgc aacctgcggc gtcacatcct gaaacagctg cgtcactgtg 3007621 cttaaaaaca tcagagatgg cacaatgaca attccgccgc caagcccgat cagacttcct 3007681 accgtacctg cgattaatcc cagtacgacc aaaatcacaa acgacatcaa tcaaaacctc 3007741 ttttctaaaa taaatcgagc tgtctcggag caagtccgct gtactcgata tcaagcagtt 3007801 caagcatctg cttgccatta tccgcagcgt caccgccgga attgttgttg aacaggacaa 3007861 aaacatcctt acattgctgc tgcaattcat tcaggtgctt tttccaatcc tccagctcct 3007921 gttggttgta gcggtataag tacctgacct cccgccagtt tttcccgcca tcaggcttca 3007981 tccagccctg cttgttgcgt ccgtgaaacc tgacgagcgt tttgttttca tcggtcgcgc 3008041 gcaacacggt cggaacgctg ccttctccga tttgcggttc atcacagaca ctgtgaatcc 3008101 agccttccgc tttcataaat gaaagcgtct gctcataaaa tggcggcgag aaccaggaac 3008161 ggtttctgaa ttcaagcgcg caaggaatat ctcccatttg gtgcttacac catctcaaat 3008221 aggcgacatt ctccttcttg cagtcaaacc acggcggaaa ttgaaacagc accatggcga 3008281 gcttattgct atgtaaatat ggcgttaaag acaccttaaa cgcatcaaac atctcctctt 3008341 ttgagtcaaa gggaatttcg ccgcgctgat gccctgtcat gccctgatat gctttcacga 3008401 taaattggaa ggtttcgggc gtttccttca cccacttttc attattgcgc gccggctgaa 3008461 tcgcgtaaaa gctcgcgtct aattccacga tcggaaaatg ggaggaatag gcctgcaatt 3008521 ttttctggct ggccgttttc ggcggataga tgctgtcatg atccccccat cccgtcagtc 3008581 cgatataaat cacactcatt cacctctctt ccagtttatc acacgtgttt tcaggtttcc 3008641 tcggaaatgc tgttcatatg gcgggaaaat gcctcacgca aatgctgata ttgttcctca 3008701 ttcgtatcta aaaacgcctc ttctcttgag gaaggaatgt gctgatattc aataggcgcc 3008761 tgaaactgct cactcgtaaa atcgtacacc acaccattga tgctgttata aaaatgccag 3008821 ctctcatcga ctcttgtttt gaaaatcgtg ccgccgaaat ggtcttgaat caccaatgcc 3008881 gtcacgccgc attggccgca tgacgggcat tcttccgtcc atttagagct cgaatggcgc 3008941 gaccaggatt gcttaagtat gtatttgaca tgctccattg cctccgcctc ctttaaaaaa 3009001 agataccacg ttgatgagat tttaaaaact agaacggagg aaatcaaaaa acccggcggt 3009061 aaaatccgcc gggcttacga aggaacgacc agagctccgt caatttcagt gactttttcc 3009121 ccatcattgt acacgcaccg gcctttgctg taagtggccg aaatgctgca gggaaatgta 3009181 tgtccttcgt aaatgctttt tttatgcttt gcaaacatcg attctcttgt aacagtgtac 3009241 ggctccatgc tgacgagcac gaaatctgca tcacaccccg cctcaagccg cccttttttc 3009301 tgaaggccga atcgttttgc aggggccgcc gctgtccatt ctgcgatggt ttcaaatgga 3009361 atctgatgct caagcgccag ttccagcatt cctaataaag tgaactgccc gccgctgatt 3009421 ccgccccatg ataaaaacat gttatcctcc cgcttcaagg atggacggca aggggaatgg 3009481 tctgaggaaa ccatgtcaat gtccccggca atgagcgtct cgatcagcgt ctcttttgat 3009541 tgccgtgacc ggagcggagg cgcgcatttt gcgacagagc ccctttgccg taaatcgtca 3009601 tggctgaaca agacataatg cggacatgtt tcaaccgaaa catcaagacc ttcctgtttc 3009661 gcctctctga tcagccggac cgctttcgcc gtgctgatat ggacaaaatg aaccggacag 3009721 cctgtcacct tcgcatactg aatcgtgcga tacaccgctt caacttctgc ttcctccggg 3009781 cgggaggcgg cgtacgcatc cgcatccacc tttcctttat tggccaaaac catctgcaag 3009841 tagcttgtga tcgcgtcgct ttccgcgtgg agagcgagga tttttcctgc agccgcgatt 3009901 tctgccatgc ctttgagcaa tgtccgttca tcaacagagc ggaactcatc agtgcctgac 3009961 tttgataaaa acgctttaaa cccgatcgct cccgcttcag ccatcggacg gatgtcctcg 3010021 atatggcctg gcacaaggcc gccccatagc gcaaaatcca cggcagattt ttgcctgcct 3010081 agctcagctt ttgcgagaag atgctctgcc gtcacggttg atggaataca gttgagcggc 3010141 atatcaaaat aggtagtgca accgcctgcg gccatcattt gagaacctgt ttcaaacccc 3010201 tcccaatcct ccctgcccgg ttcattaaaa tgaacatggc aatctatcac accaggaaac 3010261 acgtatttcc cgtctgcctg gatgatttcc gtcccgcttg cttcaatgtc agaacctatc 3010321 tcggcaatga caccgttttg aactacaata tcagcttcta taacgccatc tggcgtaact 3010381 gccttcgcac cttttatcac catatcgtaa gccatattga tccccccatg tcaggatgac 3010441 gattttccat gtcagtttat gtaacacaac cagttctatt ttcaacagtt tactgctact 3010501 atgatcgtat tacatcagca aaaccgctag aattcctatt gaaaattatt caccttaacc 3010561 aatgttttta tagaaaagga gaatgcgcta tgaatattct tgatgtgatg aaaataccgg 3010621 cttttgaaaa cgccaattta atcgctggaa aagcaggagg ggaaagagag gttcagcatg 3010681 tcaatatgat ggacgctccg gatatcgtag actttttgca taagaatgaa ttgctcgtca 3010741 ccaccgccta tcacctgaag gatcacccgc atcaattatc tgaactgatt cggcaaatgg 3010801 caaaacgcgg ctgcgcgggc ctcggcatta aaacaaagcg ctatctggaa gatatcccga 3010861 aggaaatcat cgaactggcc gattcatatg cgtttccgat cattgagctt ccggaacaca 3010921 tccgactcgg cgatattgtg aatgccacac tcagccatat tctcgatatg cgttctaacg 3010981 agctgcagca agccatttac gcgcacaaaa aattcacaaa ccacattatg agcggcaagg 3011041 ggctgcaatc cctcctcaaa aaggtgtcag acatccttca gcttcccgtg ctgctgcttg 3011101 accagcatgc caaaatgctg tctgcgtctc atcagatttc agttgagacc gaaaagctga 3011161 aaggcaccct gaataccgta tccgggccat ttttcacttg tttctctaca atctcagatc 3011221 agaaaacata ttctgtcctg cctatttata atcacgaaaa aaactgcggc tacctgctga 3011281 tacccgacat ggtgcaggca ggcgacaaag gattgatcct cacgattgaa caagcggcca 3011341 acgtcatttc ctttgaactg ctgaaggaaa atgcgctgaa gcagttcagc cggcgggccc 3011401 gcaatgagtt tttcaacaat tttattgagc ggaccttttc ttcagatgac gaaatcaaaa 3011461 accgggcgaa agaattcaag ctgcgctggg atcaaaaata catgtgcatc gccggcaaac 3011521 tcgatcgcaa tgacgaatca atcagcttta cagaaaatca gctcgcttcc gacagcgtat 3011581 tcgaatttct tgaaggtgaa ttatcagcct tcccgtttcc acctcacttc tttatgaaag 3011641 gaaatgtcgg cattattcta atcgaggcga cagacagctg gagtgaaatg cacgcctcgg 3011701 tgatcagctt tttagaacag tttcaaacac aggtcagcgc tcaatttaaa cgaaccgtgt 3011761 cctttggcat cagcaatatc tgccaaaagc tcattgatgt tcccgacgct ttcacagaag 3011821 cttctgatgc tctgcaatcg gggcatttgt caagaagcac cgcatttatc caggtgtatc 3011881 acgccaaaga tgtgcctgag cttctgcgct tgctcccagt tgaggatttg aagaaatttt 3011941 acaactccac gcttcagagc ctcgctgaaa aacagcagga ggatcaaagc ctgcttcata 3012001 cgctttccgt ctatttagag acacactgcc aaatttcaga gacggcaaag cgtctgtacg 3012061 ttcatcgcaa tacggtcata taccgccttg aaaaatgcga agagcttctg gggaaaagct 3012121 taaaagatcc tgaaacaacg atgcgtttgc ggcttgcatt acgtatgcag cggctgatca 3012181 gctaaagttt gttacatttt cttacaaaac gaatcgtttt tcgtcacttt cagcaatcac 3012241 acctgtcttt ttcagctact gtatccaatg acacccctcg accggaacga tattatgtta 3012301 ctaaagttca catacaggga gggactatag tgaaaaaaag atcgtttaag gtgtttacac 3012361 ttagcctgca gcatgtgctc gccatgtatg caggtgcgat tttggtgccc ctgcttgtcg 3012421 gcagggcgct gaatgtaaca actgaacagc tgtcctacct attggcgatt gacctgttaa 3012481 catgcggcgt cgctacgctt ttgcaaacct tgcgcggaac atacatcggc atcgggcttc 3012541 ccgtcatgct tggcagttca tttgtggccg tcaccccaat gattgcaatc ggcagcaatt 3012601 acggcattca cgcgatttat ggttccatca ttgcggccgg tgtgttcatc tttttgtttg 3012661 cgcgtttttt cggcaagctg actgtgttat ttcctcctgt cgtaacaggt accgttgtga 3012721 ccttgatcgg cctttcactt gttccgacag gtgtgaaaaa tatggctggc ggcgaaaaaa 3012781 taaacggcag cgccaacccc gaatacggtt cgctcgaaaa ccttcttctc tctgtcggtg 3012841 tccttgttct gatcttagtc ctcaaccgct ttctcaaagg atttgcccga acactgtccg 3012901 ttctgatcgg catcgccgcc ggaacagcgg cagcagcgat catgggcaaa gtcagctttt 3012961 cttctgttac agaagcaccg ttcttccaaa tcccgaagcc tttttacttc ggagcccctg 3013021 cgtttgaaat cggtccgatc ttaacgatgc tgatcgtcgg aatcgtcatt attgtggaat 3013081 caaccggcgt tttttacgca atcggaaaga tatgcggcag acctttaact gacaaagatc 3013141 tcgtcaaagg ctatcgagcg gaaggaatcg ccattctcat cggcgggctg ttcaatgcct 3013201 ttccttataa tacctttgcg caaaacgccg gcttattgca gctgaccaaa gtgaaaacaa 3013261 gaaacatcgt cgttaccgca ggctgtatcc ttgtctgtct cggactgatt ccgaagattg 3013321 ccgcccttgc atctgccgtt cctgctgctg tacttggcgg cgcgaccgtc gtcatgttcg 3013381 gcatggtgat tgcctccggc gtcaaaatgc tcagcacagc ggatctcaaa aatcaatacc 3013441 acctcctgac catcgcatgc tcaatcgcac tcggcatcgg cgccagcacg gcccccggga 3013501 tttttgctga attccccgct ccgatccgga ttctggtcag tgacggcacc atcaccggaa 3013561 gcctaaccgc catctttttg aatctatttt tcagcttgcg cgacaaaaaa gaattaacag 3013621 cacagcaaac agaacttccg gtattagaac atacactcgc attagaaaaa gaggtgtaaa 3013681 aaagatgaag gaacagcaca atgccttaca gctaatgatg ctggggcttc agcacatgct 3013741 tgccatgtat gcgggagcca ttctcgttcc gttgatcgtc ggagcagcga tcgggctgaa 3013801 tgcggggcag ctgacgtatt taatcgcgat tgatttgttt atgtgcgggg cggcaactct 3013861 tttgcagctc tggagaaacc gatatttcgg catcggcctt cccgttgtgc tcggatgcac 3013921 gtttaccgca gtcggcccga tgatttccat cggaagcact tacggtgtcc cagcgatata 3013981 tggtgccatt atcgccgcag gactgattgt cgtcttagcc gcgggcttct tcgggaagct 3014041 tgtccgtttt tttccgcctg tcgtaaccgg atcagtcgtc atgatcatcg gcatcagcct 3014101 gattccaacg gcaatgaata acctggccgg aggtgaagga agcaaagaat tcggctcact 3014161 cgacaacgtg ctcctcgggt ttggcgtcac agcttttatc ttattgctgt tttatttctt 3014221 taaaggcttt atccgctcca tagcgatttt actcggtctt atcgcaggaa cagcggctgc 3014281 atatttcatg ggaaaggtcg atttttctga ggttttggag gcgtcttggc ttcatgttcc 3014341 gtctctgttt tatttcggac cgccaacctt tgagctgccg gctgttgtca cgatgcttct 3014401 cgttgcaatt gtcagcctcg ttgaatcgac aggcgtttat tttgccctcg ctgatatcac 3014461 aaaccgcagg ctgtcggaga aggatctgga aaaaggctac cgggcagaag gccttgcgat 3014521 tttgctgggc ggcttattta acgcgtttcc ctatacagct ttctcgcaga atgtcggcat 3014581 cgttcagctc tcaaagatga aaagtgtcaa cgtcatcgcc atcacaggaa tcatactggt 3014641 cgcgatcggg ctggttccaa aagcagcggc cctgacaaca gtgatcccca ccccagttct 3014701 cggcggcgca atgatcgtca tgttcggcat ggtcatttct tacgggatca aaatgctatc 3014761 cagcgttgac cttgattcgc aaggcaacct gctgattatc gcctcttccg tcagcttggg 3014821 gcttggcgct acaacagttc ccgcgttgtt ttcatctctt tcgggcgcgg cctctgtctt 3014881 ggcaggaagc ggaattgtga tcggcagttt gacggccatt gcactgcacg ctttttttca 3014941 aaccaaacag ccgaatagcg cagacataaa aacgtaaagg aagatgccaa tgttcacaat 3015001 ggatgacctg aaccaaatgg acacacaaac actgacagac acacttggct ctatttttga 3015061 acactcttca tggattgcgg agagatccgc agcactacgg ccgttttcgt ccctttctga 3015121 tcttcaccgc aaaatgactg gcattgtaaa agctgcggat cgcgagacac agcttgattt 3015181 aatcaaaaag catccccggc tcggaacaaa gaaaacaatg agcgatgact cggtacgaga 3015241 gcagcagaac gcagggctcg gcaaattaga acagcaggaa tacgaggagt ttctcatgct 3015301 gaatgaacac tattatgatc gcttcggctt tccttttatt ttagcggtga agggaaagac 3015361 gaaacaggac attcaccaag ccctgctggc aaggcttgag agcgaacgag aaacggagtt 3015421 ccagcaggcc cttatagaaa tttaccgaat cgcccgcttt cgtctggctg acatcatcac 3015481 tgaaaaagga gagacgcaaa tgaaaagaac catgtcttat ggcaaaggaa atgtatttgc 3015541 ataccgaacg tatttaaaac cgctcactgg agtgaagcaa atcccggaat catcttttgc 3015601 cggaagagat aataccgttg tcggcgttga tgtgacatgc gaaattggcg gagaagcctt 3015661 cctgccatca tttacagacg gagacaacac tctcgtcgtg gcaacggatt caatgaaaaa 3015721 ctttatccag cgccatctcg catcctatga aggaacgaca accgaggggt tcctacacta 3015781 tgtagctcac cgatttttag atacctattc tcatatggac acgatcactc tgactggcga 3015841 agacattccg tttgaagcaa tgcctgcata cgaggagaaa gagctcagca caagccgcct 3015901 cgtcttcaga agatcgcgta atgaacgaag ccgctctgtg ctgaaagcag aacgaagcgg 3015961 gaataccata acgattacag agcaatacag cgaaatcatg gatcttcagc tcgtcaaggt 3016021 gagcggcaac tccttcgtcg gcttcatccg ggacgaatat acgactctcc cggaagacgg 3016081 caaccgcccg ctgtttgtct atttaaacat cagctggcaa tatgaaaata caaatgactc 3016141 atacgcttct gatccagcac gctacgttgc ggctgaacaa gtccgcgact tagcgagcac 3016201 cgtttttcac gagctcgaaa ccccttcaat ccaaaaccta atctatcata tcggctgcag 3016261 aatattagcg aggttcccgc agctcactga tgtcagcttc caatctcaaa atcacacgtg 3016321 ggatacggtt gtcgaagaaa tcccgggctc aaaaggaaaa gtctacaccg aaccgcgccc 3016381 gccatacggt ttccaacatt ttaccgtgac aagagaagac gccgagaaag aaaaacagaa 3016441 agccgctgaa aaatgtcgga gcctgaaagc ctgatgggaa aactgacaac ccatatttta 3016501 gatttaacct gcggcaaacc agcggcgaac gtaaaaattg gattgaagcg gctgggcgaa 3016561 agtattatga aagaggtata cactaacaat gacggcaggg tcgatgtccc tctgctggct 3016621 ggtgaagagc tgatgtcagg agagtatgtg atggaatttc atgcaggaga ctattttgcg 3016681 agtaaaaaca tgaacgcagc cgatcagccg tttttaacca tcgtcaccgt ccgttttcag 3016741 ctagcagatc cagatgcaca ttatcatatc ccgctcttgc tgtcgccgtt tggttatcag 3016801 gtgtataggg ggagttaaga aggaagcccg cctcaccggc gggcttcttt ttgcacttca 3016861 attaactttt gatcctagga cagtacttga agtgatcccc acacttagtg aaacaacagc 3016921 tagaataaac attcacctat atttttcagg ataattgcct acgagaaaaa taccctgtag 3016981 tcctttcatt tataaatcga ggtttcaaac taataagtca gctcttagca gccgagctcc 3017041 cttctccaat cctataaaca gaccgcgttt tttctcgaaa aaatactctg aagacaattg 3017101 ctgcgttttt aatagttttg ataacgcgtt ctctcttaca cctttagaca aaatattcat 3017161 tttttctttt ttagacttaa atctatgtcg aaaataatcg ttggcatatc ttatcctatc 3017221 tccactaaag gaggtgacat tatgggattc tacaattctg gtggatacag tggaaactct 3017281 ggttactcaa acggtttcgg gagctccttc gctttgatcg tggtgctatt cattttgttg 3017341 atcattgttg gagcagctat ctttaattat taagtttaac tttccttgcc tccgccgtat 3017401 ccaacacctc cctgtccgac agacgccata agaagttttt atggcgtctt tgctatgtgt 3017461 tcactaatct ttttgtaatc cagaagctgt caagttctac gagatttatc gtgtgttttc 3017521 ccacaacgct tctgcgtctt gatcgcgctg tctgactgag gctaaaaaag tccggctttt 3017581 aaaagccgga ctcccgtcta cccccgttca actctcttct aatcctgcaa gctgaccgca 3017641 taatcccgcc atacccggta caccggcaca aattccccgc cagcccttct tctatatctt 3017701 tgtcagaagg ttgaggggtt tcccgaaaca atgctttaag cgcaatgatc attcccggcg 3017761 tacagtagcc gcattggaag ccgccttctt ccaggaaagc ggtttgacac atatccagct 3017821 cttctttttg aagcccctcg atggttgtga tggaatggcc gtctgcttga taggccatcg 3017881 tcatgcacgc attggccagt tttccgtcga ttaaaataga gcaggctccg cagcggccga 3017941 ttccgcagga cacctttgtc ccggtcagct gaaattcctt tctaagcagg tcactcagat 3018001 gtgtcgtagg aacggcagca acctcccacg cctgaccatt cacggtcatc cggaactgtt 3018061 ccttttttac aggaaatggc ccggcctctt ttatgtccat tgcttcagcc cctttctgtc 3018121 gatcgcttca agcaactctt ctcttgaaat tggcagcttg tttatccagc atccgaccgc 3018181 atcatgtact gcctttacaa tcgccggagt gatggcgatt gttccgattt caccaacacc 3018241 gcgcggtcca tatacgtctc ccttcattaa gtcttctatt gcaatcagct tcatgtcagg 3018301 aacatctttg attccgggaa tcaaatagtg atcgagattt tccgcagcat aacggccatc 3018361 cgtcattttc gcttcctcca tcagtgtgta gccgagtgcc atggcagcgc cgccttcaat 3018421 ttgacctcga tatccctgcg gactgacaac cggacctgcc gcaatagcgt gctcacaatc 3018481 tatcaatttg acatcgcctg ttaacagatc tacctccacc tcaacggcag ccgctccaaa 3018541 tgagtagagg aaatggccgc ccaccacagg atcaggcgtt gttggaaagt caaaggccgt 3018601 ttcctctgcc aaagggcctt tttcagccag ctccttatac gtcaccacga gcgcctttgt 3018661 gtttttgtca cgcaagcctg cagcgccggg aataagattt tccgctgaac agccgctcca 3018721 ttctgccgcc cgttttttca actgagctag aaacggcttc ttcaaacgct ggatcgcgtg 3018781 ccacaccatg cttgtgccgc gggatgctgt ggaggagcct gacttcggca cttttgcggt 3018841 atccccaata acaatggaaa tatcctctgc ggcacaaccc agctcctcca tgacaatctg 3018901 ttcaatcgct gctagaatcc cctgtccgca ttcttcaaat ccaaacgaag cagtgatttt 3018961 gccttcactc gaaagagaca aacggcctcc tgccgcatcc attcggccaa accccagccc 3019021 gccgccgtgc attgtaattg ccgctcccgt gcctctttgc agatacccgc agttccggct 3019081 tgttttttta agaatgggag atttagatat ggcattcaac acctgtgccg ctccgtcagt 3019141 tggtgcaatt cgatgctcaa gcggccccaa gtcatgcggt tttctgatat tttttcttct 3019201 cagctcgagc gggtcgatgc caagcatgcc gctgagacga tcgagatggg tttcgagtgc 3019261 aaatgtgatt tggttgccgc caaagccccg aaattccccc gccaccccgt tgttcgtaaa 3019321 tactgatatt ccttcagtcc ggatattcgg aatacggtac ggccccgcgg catgctcgac 3019381 agaaaaatca agaacagccg gtccgagcgt agcgtaagcg cctgtgtccg ccacaatttt 3019441 cacgtcgtgc gccaatagat ttcccgaatg atctgcaccc gtttttatcg taatcttcat 3019501 cggatggcgc ttaatgccag aacgtacaga ttcctttcgt gtctgatgaa ttttgacagg 3019561 gcgtccgctt ttcagggcca aaagcgcagc atacggctga atattcagct catccttccc 3019621 tccgaacgag ccgcccatcg gacttgacac aattctgatc ttctcttcag gaatatcaaa 3019681 aatacgggca agctggaaac ggtctttata gccgtgctgg gttcctgcat acatcgtaaa 3019741 acccccgtcg tcttccggaa cggctacacc tccctccgtt tccatatacg tatgcatctg 3019801 ccgcggcagc tcataggttt cttcaaagac tgtgtcagat gcttgaaacc cttcttccac 3019861 atcaccgttt gaaaaaaatg cgcggtgcag gatattcccg tcctcatgca gtctttgcgc 3019921 attcggccga agcgcttttt ctggtgaatc catgacttcc agctctttat actcaacttg 3019981 aatcagctcc agcgccgctt ccgcgatttc ttccgtttcc gcagcaactg cggcgatcgc 3020041 atccccgaca taccgcaccc tgtcctcaca taaaaccggc tgatcaggga tgacaatgcc 3020101 aaatcggttt aagccgggaa cgtctttatg tgtgacgacg gcctgcacgc cttccatttt 3020161 ctcagctttt atggtgcaaa ccgacacaat ctctgcatga ggataagcac ttctcagcac 3020221 cttgccatac agcattcctg gaaagctgag atcggtcata tatttcaatt cccctgtgac 3020281 cttacccctt ccatccggcc tgactcttga cggtttgttg atgatcattt attcccctcc 3020341 ctcagccatc agctctgcca tgatgacgtt ggcagcggct ttttttctgt atgccgctga 3020401 cataaaaaca tctgaggaaa acggcagctc atggataagt gttttgtaca gctcatgcgg 3020461 gtcccaccct ggtgccatcc atttcgcttc gctgtccaat aatctcctag gagtgatatc 3020521 ggcatggcca gcggcgaggc gaatgctgcc gtctttcaaa aaacgtccag ctgcaacagc 3020581 agccgctccg gtaaaagcct ggcgccttcc aagcttgtga taaaatacac gctctccctc 3020641 cgcccgcggg atgatgacac gcgtgacgat agccgttcta aagtcttcct cactgagcca 3020701 agcgccaagc ggcagcctga ttagctcctt ttgatatacg ataagctcag caccaagcac 3020761 aagcagaagc ggaatgaaat caccgatttt actcgctatg ttgccgccaa tcgtggcacg 3020821 gctgcgaatc cccggtgcag cgacagcgga agcagcgtca ctgaaacagc taagcgctct 3020881 cttaatcaaa gggttctttc tgcattcatt cagtgatgtg agccccccga tcgacacgtg 3020941 ggtgtcactg gtgctgatcc ctcgcatttc gtcaatccct tcaaggctga caaggtgctg 3021001 tttcggtaga gttcctttgt cccactgaag ctgaaggagc gtgcttcccg atgcggcaca 3021061 cacatccgga gcaagcttct ctaaaagcga ataggcctca tcaagcgctg ccggtctcca 3021121 taattgaata ttcatccttg cttttgtcac ttggccgttc aagacatcgc cctccttacc 3021181 atgtcatatt cctcgggtgt atcaatatcg tccaactcac cgctatcctt tgcctccaaa 3021241 accgctcctg ctccaagctg tccgcttttc aggagcctgc gagccccttc atctcccttt 3021301 aatcccttta cataaggaaa acatgtcgac gagaagtaga ttggcggggt gaacgcccct 3021361 aaaaacgatg acacggcaaa tgactcagga gccagagcca caagggcatt gagatgatcg 3021421 acggaaagct gaggctggtc ggctaacaaa atgacaatgc cgtccgcccc catgctttct 3021481 gcttttctca ccccgctgct gactgaatgc ccctgaccct tttctgcgtc ttggcaaacg 3021541 tgcaggctcc agcgtttttg aaaaggcgga gcgtgatacg gcgctcctat ccactcaagg 3021601 gaggcatgtt ctgtccgctc gacgaccagc acgtgatcaa ggcgggacga cagagcagtt 3021661 ttcaaggaaa gtgagcctat gttttctcct tttagcggca aagccagctt gttttgtccc 3021721 attcttctgc ttttgccggc agcgagaaac acgccgatca gataggggct tctcatacaa 3021781 ccgccacccg ttttcttgtt tgaatgattt ctgcaactac acttaccgca atttcctcgg 3021841 gaccttccgc accgattttc agcccgaccg gactgtaaaa gtgagacgga ggatgttttc 3021901 cgctcagcag ccgtttcgtg cggtttgccg aacccaacag tccaatataa tggaggtttt 3021961 gagaaaataa gaagttgatg atcgtttgat cgtgctgata atgatgggtt gccacaacag 3022021 ctgcatcatg cggaaaaaat tgaaattcgc taagcatttg ttccggaaaa gcggtgatca 3022081 gctgatccgc ttttggaaaa agagaggatg tacaataagc gggccgccaa tccgtcacga 3022141 taacagaaaa ccctgtgtca gccgccaaat tggccagcgg tacattatcc ggtcccgccc 3022201 caaacagaat gagacgcggc ttcggttcaa ttcgctgaat aaacatgtta gtggtttgat 3022261 cgaaatgcgg taaatgaagc gttgaaacag tacgttgaat atcttgcaga ggcgcgtccg 3022321 gccagttccc aaaatgtccg ttctccgtca gaaataaata atgggaggat tcaatcttta 3022381 taacggaagt gacagctttg cctgaatgaa ggcagtccct cactttctca tagtgccgcc 3022441 ttttttcctg agtgattcgc tctgcatgaa catgaataat gccattgcac ccggctccca 3022501 tgccccaaga aagatcgtcc tccgaccgca tgtcgtaggg aatcagcgtt gatgtgagct 3022561 gatcgcccag cgcactgatt ctttggaata catcttcttc cacacacccg ccgctcagca 3022621 agccaatccg tctgcctttt ttcttaaaga gcatagaggc gcctgctttt cgatacgcgg 3022681 agccttcaac ttgaacaatt gtcgccagta cagcctcctc ctggtcttcc aggagcgcat 3022741 ctaacatcgt gtgaaaattc cccaatgccg catcctcctc tcgaaaattg ccgtgagaaa 3022801 caactagttc agcgtgattt tataggtaac ttgtataaag aatagacgat ggaagaaaaa 3022861 atgactcatg atttgtcaga aaatgaaaca catagaaaga ggatttgtaa aaagagtcaa 3022921 acgaagaaaa tcagattgga gaaaacacga aatcatatcg ttaaaaagct tgcggagttc 3022981 cgcaagcttt tctttacacc gctgcctggc ggccagcgtt ttcatacaca tccagcgctg 3023041 cttggagcgc ttttcctgct tcgattcctg cgttatgtct gagaagcaca gcctctaacc 3023101 cggcaagcac gaatagcacg ttttcttttc tgcagctgta ccccatcgtg ccgatcctcc 3023161 agatcttccc tgcaagcggg ccgaatgagc tggcgatttc aatgccgaat tgtgccagca 3023221 gcatgtcacg gacagactcg ccgtcaatgc cgccgggaat ttcgacacag gtgacaacag 3023281 gcattttgca gctgtcatct ccaaacaatc ttagccccat tgcctttatc cctgctgcta 3023341 atgcggcttc atggtgccga tgccgctcga aacgcgtctc aagaccttct tcaagcacca 3023401 gtctgactcc ctcacgtaag gcgtacagca tcgtcgtcgc ttctgtatga tgattgagcc 3023461 gtctttcgct ccaataatcc tcaagctggc tcaaatcaaa gtagttgctt gtaattggcc 3023521 gatttcccga aagtgctgcc ctgtcagctt gtgtcgcaat cccgcgttcc acctttttgc 3023581 gagctgcaat cacgtccgcc acccgctcat tatatgtaat cggcgccatt cctgaaggca 3023641 cagacaaaca tttttgcgtt ccgccgatgg cagcgtcaat cttccattca tcgactttaa 3023701 cctcgcagcc cccaatcgtt gcgactgcat cgacgataaa caatgcatcc tcggtgcggc 3023761 aggcttcgcc gatggctttc agcgggtgaa tccgtcctgt cgatgtttct ccatgcacca 3023821 tggccacaat tttcggcttc acttttttta tctcccgtat gatgtcctcc gggtcaaaaa 3023881 ccgttcccca ttcgcactcc agcatatgaa catttgcccc atatcgctcg gcgatttcag 3023941 tcagcaaata accgaaacgg ccgtaaatgg gaatgagcac atcatcttcc ggctctatca 3024001 cactagccag cactgcttca attcccgccc gtgaagtgcc gtcaatcggg tatgcccagc 3024061 ggttttttgt ttggaacagc tcccgaagca tctccatcgt ttcattcata atacctgtaa 3024121 acgccggatc aaattggccg acaaccgggg tgctcattac tcttaataca cgcggatcaa 3024181 cctcaacagg ccccggtgtc ataatcgttc ttaacggggt gcataattct cttctgcctg 3024241 acacagccat tcctccttta tcagtaagcc agtttgtata ataaatcagt cagtgcgcgg 3024301 acgccgatct caagctgtct ggctgacgta tattccttcg gtgagtggct gacgccgcct 3024361 cggctcggca caaacagcat acaagcagga tagcgccttc cgatcatttg cgcgtcatgc 3024421 cctgctccgc tcaccatttc ctcacagctg aagccgtttt ctaatgctgt ttcaaaagcc 3024481 gcagccttca gcctttcgtc catcggcaca ggctctatcc gcatatattc atcaatcaca 3024541 gcgcgaattc ctttttgtag gcaaatgccg ttgatcaaag caaccatgtc ttgatgaaac 3024601 tgttccagca catgctgatg ctgatggcga atatcgattg aaaactggac gcggcccggt 3024661 atgacattgg ctacattggg ctctgccgtt atttttccgc atgtcagacg gagctcatcc 3024721 ggcagctcat ccgaccgcag cagcagctca tgaatgatac ggctgctggc tgcgagcggg 3024781 tccttgcgcc atttcatgga ggtggttcct gcgtgattgc attctccttc gagcgtgacg 3024841 agatatcgtc tctgccccgc aatacttgtc acgatgccga gatcccggcc tgacatttcc 3024901 aacgtcttcc cctgttcaat atgcagctca acaaacgcgc tgatatctgt cctatatgct 3024961 gactgaaaca cacctttgcc aaaaccgctc tcatgcatcg ctgtttggag ggagactccc 3025021 gactcgtctc ttggctcttt tgcatcttgt tctgaaaaaa cacccgtcat attccccgac 3025081 ccccaatagg tcattggaaa acggctgcct tcctcctcac ataaggagac cgcctcgagc 3025141 gttttttttg gcgctccgta tgtttccttg agctgcttta acgcgagcat tgccgccaga 3025201 acgccatagg cgccgtcgta ttttcctcca ttgatgacag tatcgatatg tgaaccggtt 3025261 acaatgactt catccggaga ctgggtgccc gaaagccttc caaacacatt gccgacatcg 3025321 tcgaatcttg tttcaagccc gaaagaagac atttccgttt tcacagcaag ctgtgcgtcc 3025381 atccactctt ttgtgtataa aagcctcgtt acgccgccat ccgcagacgc accgtattgg 3025441 gcgagccatt caatataatc tgtgatgctg ttttttactg aaagcttctg cttttccatg 3025501 tactcccccc tctggccgct atggtgactt cattatagaa ggagcaacat gatagttcat 3025561 tgacagatta accaaaaaaa cgtttatttt ttagccacag tatccatcca gcaaccagat 3025621 acaccctaca tgtcacaact attttgatgt aaaggtcaaa agaaaacacg gtaaggaaga 3025681 gagccagcaa gagcgaaaga gagggtcaaa atgcctttca tatgaacaag ctaagctgga 3025741 gaggcgatgt tcgcggaacg gatgaaaaca gaaatgccgg cagcccgcaa aaacaggacc 3025801 taaagatatg gaaacaggag atttccgcct cctccaaagg gactaattta caattttaat 3025861 gaaaaatata caaaatgaca cttctatcct ttatttcaat tttagataat agatatgatc 3025921 tgataaaagg agggcaagtg atgacaaaaa aagcatggtt tctgccgctc gtctgtgtat 3025981 tactgatttc cggatggctt gcgccagcag cttcagcaag cgcgcaaacc acattaagcc 3026041 ttaatgaccg attggcgtct tccccttcag gaacgggaag ccttctctca ttagccgccc 3026101 ccgctgcacc ctatgctgac acagatacct attatgaagg ggctgaaggt aaaacaggag 3026161 actcgctaaa aagcaccctg caccgtatta tcagcggaca cacgatgctg tcctacagcg 3026221 aagtgtggaa cgcgctgaaa gaaacggatg aagacccaag aaatccgaat aacgtcatcc 3026281 tgctctatac gaatgaatcg cgttccaaaa acctgaacgg cggcaatgtc ggcgattgga 3026341 accgcgagca tgtctgggcg aaatcccatg gcgattttgg tacgagcaag ggacctggta 3026401 ctgatattca tcatttgcgc ccggctgatg ttcaagttaa cagcgccaga ggaaatatgg 3026461 attttgacaa tggcggcact gaatatgcga aggcacccgg aaattattat gacggcgatt 3026521 catgggagcc ccgcgatgat gtgaaaggcg atgttgcccg catgctgttt tacatggctg 3026581 tccgttacga gggtgatgac ggctatcctg atcttgagct taatgataag acaggcaacg 3026641 gctcagctcc ttatcatggc aaacaatctg tcctgctcga atggaataag caggatccgg 3026701 ttgacgaccg cgagcggaaa agaaatgaaa tcatttatga aaaatatcag cacaaccgca 3026761 atccatttat cgaccaccct gaatgggcgg atgagatttg gccgtaagaa aaaggtgctc 3026821 cttttgagga gcaccttttt ctaatacaca gcctcttccg tttccgcatc gaaaaagacg 3026881 acgtggtcca ttttcactga gagctggatt gaatcgcctg catcgattcg cgtgtttccg 3026941 tccaggcgga ccttgagccg ctcgtcccca gccatgacat gcactatgag ctccgagccc 3027001 agattttcat tcacttccac gttcgcttga aacactgaat caaacaactg gtcatttcct 3027061 gtcatttgtg tgatgtgctc cggccgtaca ccggcaatca tctgttctcc ggcatatccc 3027121 ttttccttca gccgctttgc tttttcttca ggaatatgaa gccggatcga agaatttgtg 3027181 aaaaacagct cgccatgctg ctgttctatg atgcctttca aaaagttcat tccgggagag 3027241 ccaatgaagc ctgcgacaaa caaattggcc gggtaatgat aaatgtcatg aggtttcgcc 3027301 acttgctgaa tttccccttc attcatgacg acaatccgat ctcccattgt cattgcttcg 3027361 gtctggtcat gcgtgacata aatgatcgtt gcctctaatc gctggtgcag cttgctgatt 3027421 tctgtccgca tcgtcactct tagttttgca tccagattag aaagcggctc gtccattaaa 3027481 aagaccttcg gctccctcac aatcgacctg ccaagcgcca ccctttgccg ctgcccgccg 3027541 gagagcgcct tcggttttct cttcagcaaa tgttcaattt ctaaaattct ggctgccgca 3027601 tgaacccgct cggcaatttc ctgtttcgcc atctttctga gctttaatcc aaacgccata 3027661 ttatcaaaaa ccgtcatatg cggataaagc gcatagttct ggaataccat cgcaatatca 3027721 cgttctttcg gcggaagatc attgacccgc tccccatcaa taagaagatt tccttcagaa 3027781 atgctttcta atccagccac catccgcagc gttgttgatt ttccgcatcc tgacggcccc 3027841 accagcacca aaagctcctt atcctttaca tctaaatcaa agtccttcac ggttaattgt 3027901 gagtgatatg attttttgac gtgttcaaat gttaatgaag ccatcagaaa agtcccccta 3027961 tcttttgacc cgttatttcg tcactggaaa caacttggtc tttctgttat ttttagagta 3028021 atcgattccc atttttgcta tatttctaaa ataaaaaatg taaatttgta ttataacgtc 3028081 ataatacatt ataatataaa taataggtta aaaggaggct accctttgtt aaacaacgga 3028141 agttctacac ctttatacat tcagctaaaa caaatcatca ctgatgacat caaaaagggc 3028201 gtgtattccc caaccgccaa gctgcctacc gaaaacgagc tttgcaccaa gtataacgtc 3028261 agccgcatca ccgtcaggaa agccattctc gatttagtcg aagaaggcta tctgatcagg 3028321 cagcagggaa agggaacgtt cgttaaaagc cctaaattaa aacgagagct gatcgctgta 3028381 aacggctact cggaatttat ggaatcaacc ggcaaaaaac cgaagcatca tgtgctgtcc 3028441 catgacatca ttccagcgtc aaaacccatc gccgaaaagc ttcaaatcca acccgagagc 3028501 cctgtggttg aattaaaacg gattttatat aatgatgatc agcctctcac ctttgaagtg 3028561 acgcattatc cgcttgattt gtttcccggc attgatacct ttattgctga cggcgtctcc 3028621 atgcatgata ttttgaaaca gcaatacaaa gttgtaccca cgcacaatac gaagctatta 3028681 aacgttgtat atgcccaaca ggaggaaagc aaatacctgg attgtgatat cggggatgcg 3028741 ctgtttgaaa ttgataaaac ggcttttaca tcaaacgacc agccaatcta ttgctcattg 3028801 tttttgatgc acacaaaccg tgtcactttt accatcaaca gcccctacac ataacaggca 3028861 taaaaaacga gacactgctt atagtattct cgttttttca ctgcttcccc cgtcctccaa 3028921 gcgataagga tagccatagc cgaaagctcc gtacacaccg caagttttcg cagccgtttc 3028981 agcagcctgg cgcaaagcat acgttatatc ctgcttcacg caaaaggcag tcaaaaagcc 3029041 tgctataaaa gaatctcccg ctccaagtgt atctattata tcagcttcca caatcggctg 3029101 atgatagact cgatcacccg cagacaggat tgctccttgg ccccctcggg tcatacaaac 3029161 cattttggct ccgtacccat gagctgtttt ggcaagctca ccgcattccg actcactcaa 3029221 atcgcttcct gaaaaaaacg catacgtcac ataaggacag accctcctca aataatcatc 3029281 ctcccgattg gttgaaaaat caaatgagac cgggaccagc ccgcacagct gcggaagatc 3029341 gttctcaagc ctgctgtaca cgctcgtatg cagcagatca tgcccgctga taaaagatac 3029401 atctttctcc tgaaacgcga ggcgaagccg ggactgaatg ccgcctttat ttgatctgac 3029461 aaaaatgcgg tccccctgtt catcaagggt gacaatcgcc atcccgtttt ctccgtgcgc 3029521 ctggcggata taatctgcat tgacctgctc cagcttgaga acgttcaaca gatgcgccgc 3029581 ggcttcgtca ttgccgacga ttccgatata ggaagactca tgcccgagcc gcttggcaag 3029641 cacagcaacg tttaaggcat ttcctcccgg gtaaaatgtt tcttgatcct ggtagtaatc 3029701 tacaacatta tctccaaccg caatcaattt catagcgctt cctcctttat ccttttacac 3029761 tgccgcttgc aatcccgcgg acaaaatatt tctgcatcaa taaaaataga ataataatcg 3029821 gcgcggctga aatcgttaac cccgccagca ggacgcccca gtctgtctgc agcgcgtctc 3029881 tgaactgcat cagcccggct ggaatggtcc gtaaattctc atcatctatg aaaataatcg 3029941 caaacataaa ctcattccat gtatggtaag ccgtcaaaat gccggatgtc accaaaatcg 3030001 gcacgctcat tggtaagaaa attctgaaaa atactccaaa acttgtacac ccatccaaat 3030061 aggccgcctc ctccaattct tttgaaatag aaagaaaata agagcggatc aaaatgatgg 3030121 tgaatgggat ccgataagcc gcatacggca agattaacgc ccaatacgta ttgtacaggc 3030181 ccagcgactg aataatagaa taaagcggca caagactgac ctgcggcgtc agcatcaatc 3030241 cgccaagaca tagcaccaaa aagaatcctt ttcctttaaa ctcaaaccgg gaaaggccat 3030301 acgctgccca tgcactgata aagacagtga tcacacacgt cagcgccgta acgatgacac 3030361 tgttcataaa ataagaagaa atcccctgat tccaggcgga aacaaaattt tccggatgcc 3030421 acgaagacgg cagcgaccag ctgtgctcaa aaatatcgtc agagttttta aaggcgctca 3030481 tcaccatcca gagaagcgga taggcaatcg caatcagata aagaaacaga aaaacccaca 3030541 cagacgtttc tccgatatac cattttcgtc taggcttatc tttcacctca atgtgctggt 3030601 caggcaccgg ctccaatctg aacgaatctg tcttcttctg aggcagcatc agttactcct 3030661 cctttccggt tttaaagaac ttcatttgca tgagcgataa tgcaagcgta atgattaaca 3030721 cgacagtggc aatcgctgag gcgtagccca tcatatcctt tgtaaaggcg cttttatata 3030781 aaaacgtgct caagacttct gacgcttttc ccggcccgcc gcctgtcaaa atgtacggct 3030841 cattaaagac cgtaaaggct ccggtcagcg tcatgaccac cgcaacaaaa gacatctctt 3030901 tcgtctgggg aacagtaata tgaaaaaact gctgaatttt acccgcgccg tcaagccggg 3030961 ccgcttcata cagttcatcc ggtatttttt gaatcgacac gatgtacagc atcgcaatat 3031021 aaccgacaga ttgccactgg gacacaaaaa tgacagaaag catagctgtg ctgtcatccc 3031081 cgagccaggc cctcgtcagc tgatcaagac cgatggcctg aagcagctga ttcaaaagcc 3031141 ctgtctccgg attgtaaata aaatcaaaca aaagcgcgat caccgtcatt gagatgacaa 3031201 ccggcaaaaa gaaaacggta cgaaaaaacg gcgaccattt tctgaccagc ttatcctcaa 3031261 gcaccgccgc caaaatcaaa ccgccaaata cctggcatac aattgagatc actgcataaa 3031321 gcacattatt ggtaagtgcc tgatagaaga caggatcatg aaataattca acatagtttt 3031381 ttaagccgat aaacgttttt tccggagaaa atgagctcca ctgaaacagg ctgaggaata 3031441 cattctcaaa aatcgggata taaacgaaaa gtaaaaaaac gagagcgggc accaaaaaca 3031501 aataggggat tattttattc tgattgacca agggtatctc atctccttta taaaaagaaa 3031561 aggtgcgaag cttcaccttt tctttgattt attcagctga cgccctcacc tgctttgctg 3031621 ccttttgaac ggctttcatc acctgctgcg gtgtcatgtc gccgccaagc atttgctgga 3031681 cgcccgttag gtacgcatct gcgacttcaa catcgacatc catatcaaac catggaacca 3031741 ttgatttggc atcaacaata tgctgaacgg cttcacgctg aatggctgtt gcattttctt 3031801 cagtagccgt accttgcact gcactgtatt tcccgacatc tttcacgagc ttttcgccca 3031861 ttcttttcga cgtcaagaac tgcaaaaatt ccatcgcttc cttcggatgt tttgttcttg 3031921 aggagatcat gaatccttcc ggcgctcccg ttaacgcttc tgaagatcct ttctgcccgc 3031981 tgatttcagg aaatgggaac atcccgagat taaccggttc aaccagcttg atttccgctg 3032041 tttccgcata tatcatcgcc gactttccgc tcttaaattg ctgtctcaca tattcgtggt 3032101 cgacggagtt tacatgttta ttaaagtaag gcatcagctc ttgaagcttt tcaagtgctt 3032161 ttacgtagcc ttcatcagta aattcacccg ttttggcgtt atagtccttt tcccgtgttt 3032221 tttcatcgac catccgctga ttaagcgtgc cgatatagtg cgagattgtc caagtcgcct 3032281 ttgttccaaa gctgatcggt gtgtagccat gttctttcag cttttttgac acatcgatta 3032341 attcatccca cgtcttcggg ggatcaagat tcagcttttg gaaaatgtct ttattataga 3032401 agaatgattt agcgtccatt tgccacggta cgccatattg cttgttttca taagtaaatg 3032461 gtgtaatttg cgattgaacg agctgtgatg accaatcggt gtcatttttg tagtaggacg 3032521 agagatcaag tgctttattg cctctgataa atttaaaagc aaactcatcg ctccaagaga 3032581 agtaaatgtc aggagggctg gtggttccca gcatgacctt aattttatct ttataggagt 3032641 catttaaaac ggcttcaatt tgaatgtcga tatctgggtg atctttttca aattccttaa 3032701 caacctcttc aaaataactt ttttccggct cctttggcca tctgtggaaa aatttcaatg 3032761 tcacctttcc gtccgctgaa ctgctttggc tcgaacagcc tgcgatggtg agcatactga 3032821 cagctgcaat gatcaagaac aacaacattt tcttcaaagg gttggcctcc tctggacatt 3032881 agactataat gttatataac attatagtct aatgcataat ggttcttcat tttcagatca 3032941 atactcaact ttccacatgt atcttctatg agataaagga tgatttctct cctctgccag 3033001 ctcgtctgca tagcttctca gcacacgatt gagaacgagc ggagcaagat agcctttaac 3033061 tgaatcgtca attgcagtga agtcgtaaga tgcagcatca agcacagtga gctttttgcc 3033121 atactttttc gagaaggtaa gcgcccgctc ttcaagaggt cttgtttcat ctaaaccgag 3033181 caggatgata aacggcacgg attcatcaat aatttcaaac ggtccgtgaa aatattctcc 3033241 ggcatgaatg gcgtgggaat gaatccattg catttccatg agaatgcaga tgctgtagga 3033301 gtaagcgaca ccgtagtttg caccgcttgc catggtataa ataatgcttt ctttttcatg 3033361 ggcttttgca aattgcttgg cgttgtcagc ttcctgctta agggcttttt catatacagc 3033421 ctgcaattga tctaagcctt caattgcttg ctcaaatttc gtattgtttt ctaatacttg 3033481 cagggttcca aaaacgattt gatacaaaac gccatagttt gtattgatcg caagcgcctc 3033541 atcaccccaa tcgtactggg caacatattg cgcttcctgc gctaaaggag actccggttt 3033601 aaacgtcatc gcaatcgtaa gtgcgccctt gccccttgca aacgcagcag ctttgactgt 3033661 ctccggggta tttcccgaat gcgagcacaa aataacaaga gacttttcac caagctgaac 3033721 agggttgcgc tgaataaatt cgttggcgct gtagagatcg gagtttattg attttgactc 3033781 tctgtcaaac acatacttac tcggatacat aatggcagaa gaccctccgc atgcgacaaa 3033841 gaatacatga tcaatggttt tccctttcaa atcctgcaag aaagcttgaa cctcacgatt 3033901 tacttttgct gtggcctgac tcaaatcctt cactcctcgt ttttattata taacgttata 3033961 taacattata tattgttata ttaaagtccg cgggtaggat tgtcaatatt attttctgaa 3034021 atttctcaat aatttattcg gatgacagac aaagggtcta tatgcgaaaa aatgcccaaa 3034081 tcaaaagcca gaacttgact taagctctgg cttcgctgtt caatccgcag actgacgtct 3034141 tatttaaaaa ataccttgtc tatattgtac ttcgagtgct gtgtattgat gatatatgtt 3034201 tcgtaaatct ctctttccat tggatcatca actacacata cctcaatttt ataaacttca 3034261 tctctgtgat gtttgatcgg tgaaacagtg tcttcgaaat gcttcttaat tctctgtctt 3034321 aactttctgg ctttaccgac aaacagcagc tcgtcatgaa tgttgtaaaa cataaaaatg 3034381 ccgcctttgt cccttgggat ctggtgaaag tcgatgaatc cgtgaatcgg ttttatcttc 3034441 ggctcgttat cattagctga ctgctgtcgt tcagtgatgg tgacattcgg tgcgggtata 3034501 tcaattttta tcaaaatcag ttcacgtcct ctttttcatt aaagataaat gctaacacat 3034561 acagaaaaga aaagctagaa cagctttatt atatttgttt gtcatgctct tacttattat 3034621 gcaagtgctc cggctggatc ataaggacta aggtctaatt ctgtctgctt tccgagaact 3034681 agctttgcga gctctgcacc caaaaacggc cccatcgtca gtccagaagc acccaaaccg 3034741 tttgcagcgt acaggccttg aacattcggc acggccccta cgaccggcag aaatcccggt 3034801 gtaaacggcc tgaagcccac tcttgtttca acagcagccg catcagcaag acccggtgca 3034861 acggctaacg ctttgctcaa tacttcgtgc tggcctccgg ctgtcacacg aagatcatca 3034921 agaccggcat cgttttcgtg tgtggcgccg gctacaattc tgccgttatc aaacgacaga 3034981 atgtactgat cactcggcgg cattacaacc ggccacgatc ctgtatctgc atctgtcatt 3035041 tcaaaatgca taatctgcgc tttttgaaat gacacttgaa aatgaatgcc aagaggcttc 3035101 aatatctcat tggcccatgc tcccgccgtc acaatgaccg cgtcagccgc aaactgcttt 3035161 gtatctgttt gcacgccggt gactgttccg ttttcaaaaa gcaaggacgc atttcctttg 3035221 atgaccgttg cgccgcgttt ctctgcagcg cttaaaagcg accggcacag cgctcttccg 3035281 ttcacacggg cggcaccgct gatatgaacc gattcatagc cgtcagctaa aatcggaaac 3035341 agctttttcg tttcacttgc agacaagcgg gtaatgtcgc cgatttccgg cgcatcctcc 3035401 cgtctcttat acgccctttc ctccatttta tcgagtttag acgcgtcagt atgaatgctg 3035461 atggcaccga cacgtttgta tcctgtatcc gattcaccgt ctttttccaa ttgatggatt 3035521 aaatccttat agtaccgcgc tcccccctta gcaagctggt accaatcctg attacggcgc 3035581 tgcgagagcc aaggacagac gatccccgcc gccgcatcag tcgcttgtcc cggctctttc 3035641 cgatcaatga cagtaacgcg agcgcctgtt tttgcgagat gataagccgt cgacgcgccc 3035701 agaatccctg cgccgacgat gatgtacgat ttcatatgca aacacctttt ctattataat 3035761 gtctattcat tttaccaaat caaatgcttt ccttcgacct tttgccctaa tgtggaaaaa 3035821 ccgcgaagtt cgtccaatct ctttactctc ctatcgaata tcctgtcact atcaatagag 3035881 aaaggatgat accatgagcg aaaatcgtca tgaaaatgaa gaaaacagac gcgatgcggc 3035941 agtggcaaaa gtccaaaaca gcggtaatgc aaaagtcgtg gtcagcgtga acacagatca 3036001 ggatcaggca caggcgcagt cacaagacgg agaagactaa tgaacgaaaa catcattcct 3036061 cttaacagac atactcaaga gatacccact actgaatctg ttatcaaaaa cagcggcaac 3036121 tcagaggtcc atatcgacat tcacattgat acaatgccaa ttgcttttgc tatattatgc 3036181 tctgcattag ccgcaaagca gatgacaaaa gaggaattcg atatggctta tactcaattg 3036241 cgagagatga acagagaaaa taacagcaga tcatctgtaa agcaaattat caatcaagag 3036301 acagaagaag agtaaaaaac cgcggcccct cggccagcgg tttttcttct gcatacaaaa 3036361 aggacgcgac tgaatcggtt acttctgtac aatttgaata aggttaccgc atgtatcgtc 3036421 gaagacagct attgtgactt cgcccatttt tgtcggttcc gtcgtaaacg tcacgccttt 3036481 ttcctttaat cggttgtact ctttttgaat atctgcaacg ccaaacattg tggccgggag 3036541 gccttcggag aatatcttct tttgatactc cttggcggca ggatgttcat tcggttcgag 3036601 taaaagctcg gttccgtctt gatcatctgg agaaacaagc gttatccacc tgaatttccc 3036661 catgggaacg tcttcctttt ttataaaccc aagtttttct gtataaaact ccagtgccat 3036721 gtcttgatct tgtacaaata tactggtaac aacgattttc atactgtttt tccctccttc 3036781 gatatgaatg aagcatggta ctatgctaac aatctggcta caagcaaaac aacccacaca 3036841 tttatcagag gccctgttct gattttataa aattattcta tccatccttt cagcaaattt 3036901 ttaagcggtt cgttgttgaa tataagtact cgatattttc cctttcgttt tgatgttacg 3036961 agtcctgcat cctccagtac agaaaggtgt ttagctatcg cctgtcgcgt aatagaaagg 3037021 tcgtactttg taataagacg tatcgtaagt tcatacaacg tcagctcgtt gcgttcagat 3037081 aattcgtcta atataagccg ccgagtcgaa tcgccgagtg ctttgaatat agcgtctttg 3037141 ttcccattca tatattgagt ataagcaacc cattagttgc atgtcaagta taagcaactg 3037201 tatggttgcg tgatatagaa actgaaccta tccggcgcag gtctgaaata ttctaatcga 3037261 taaggaatta aaaccattaa aataacagtg gatatgtctc tgaaaaataa aagaagacga 3037321 acttcaaaag ttcgtcttct acaatcaaat tcggcacgcc ggccatttta aagttgataa 3037381 ctatctctaa accccttgat aaacaaagga gttttcatca ttaaccgata gaaccttcca 3037441 tttcgaactt aatcaaacgg ttcatttcaa ctgcgtattc catcggaagc tcttttgtga 3037501 atggctcgat aaagcccatt acgatcattt cagttgcttc ttcttcagaa ataccgcggc 3037561 tcatcaagta gaagagctgc tcttcagata ctttagacac tttcgcttcg tgctccaatg 3037621 aaatgttatc atttaagatt tcattgtaag gaattgtgtc agaagttgat ttgttatcca 3037681 taatgagcgt atcacactcg atgttagagc gggcgccttc cgctttgcgt ccgaagtgga 3037741 cgattccgcg gtacgttact tttccgccct gttttgaaat cgattttgat acgattgtag 3037801 atgatgtgtt tggtgcaagg tgaatcattt tcgcacctgc atcctgatgc tggcctttac 3037861 ccgcaagagc gatagaaagc gtcataccgc gcgcgccttc gccttttagg atacaagccg 3037921 gatatttcat tgtcagctta gaaccgatgt tgccgtcgat ccattccatt gttgcgtttt 3037981 cttcacagac tgtacgcttt gttacaaggt tgtaaacgtt gttcgcccag ttttggatcg 3038041 ttgtataacg gcagtagccg ccttttttca cgatgatctc aacgaccgca ctgtgaagtg 3038101 agtttgttgt gtaaacaggc gcagtacagc cttcaacata atgaacgctt gcttcttcgt 3038161 caacaatgat cagtgtacgt tcgaactgac ccatgttctc agagttgata cggaagtaag 3038221 cttgtagcgg tgtttcaacc ttcacgcctt taggcacgta gatgaaagaa ccgccggacc 3038281 aaacagctga gttaagcgcc gcaaacttgt tatcagtcgg cgggattact tttgcccagt 3038341 gctcacggaa aatatcttca ttctctttca gcgcgctgtc agtgtcttta aagacgatgc 3038401 cttgtgcttc aagatcttct ttcatgttgt ggtatacaac ctcagattcg tactgagcag 3038461 aaacacccgc aaggtatttt tgttcagctt caggaatacc gagcttgtcg aatgtttgtt 3038521 taatttcttc aggaacttca tcccaagaac gctctgaacg ctcagacggt tttacgtagt 3038581 acgtaatttc gtcaaagttc agtgagttta aatctccgcc ccattgaggc atcggcatat 3038641 tgtagaaatg ctcaagtgat ttcaagcgga agtcaagcat ccattgaggc tcttctttca 3038701 tgcgagaaat ttcttctacg atttcttttg tcaatccgcg ctctgaacgg aaaatggaaa 3038761 cgtccttgtc gtgaaaacca tacttgtatt caccaatatc aggcattttt ttagccatcc 3038821 attttcactc caatcctttt aattgccgcc ttcttctttc gcgactcctt tttcaagtgc 3038881 tttccatgac agggttgcac atttgatacg ggcagggaat tttgaaacgc cttgaagggc 3038941 ttcaatatcc ccgagatcta tagaatcatc atactctttc ccttgcatca tatccgagaa 3039001 aatcttagac atggaaaggg cagtttcaat atctttccct ttaatcgcct gagtcatcat 3039061 cgaagcggat gccattgaaa tggaacagcc ttccccttca aacttcgcat cttccacgat 3039121 gtctccgtca agcttcattg tcagtctgat gcggtcgccg catgtcggat tgttcatatc 3039181 cacgacaatg ctgtcattta aaaccccttt atttcgcggg tttttgtaat gatccataat 3039241 cacctgtctg tacaatgtat ctaagtttgc attaaaagac atttgtaaaa tactcctttg 3039301 tcttttgaag agcttccaca agcttatcaa tctcttcctc tgtattatac agataaaagc 3039361 ttgctcttgc agtagcagtt acatccagcc atttcatcag cggctgcgca caatggtggc 3039421 cggctctgac tgcgattccc tccgcatcaa gcacagtcgc cacatcgtgc ggatgaacat 3039481 catcaaggtt aaatgtgaca agcccggcac gctcttccgg cccgtaaacc gttacgccgt 3039541 caagctggcg gaagcgttca agcgcataag ctgcaagctt gtgctcatgg cgggaaatct 3039601 catcaagacc gatttcttcg agaaaatcaa tggcggcacc gaggccgatt gctcctgcaa 3039661 taatcggcgt acccgcttcg aatttccacg gaagctcttt ccaagttgat tcataaagcc 3039721 cgacaaagtc gatcatttca ccgccgaatt cggcaggctc catgttttcc agcagggctt 3039781 tctttccgta cagcacacca acaccggtag gtccgcacat tttatgggaa gaaagcgcaa 3039841 agaagtcgca atcgagatcc tgcacgtcaa ttttcatgtg aggcgtgctt tgtgcaccgt 3039901 ccaccacaat gacagcccca ttgtcatgag cgattttcgc catttcttta atcgggttga 3039961 ccgtgccgag aacattagat acatgagaca ccgcaacaat ttttgtgttg cttgtgaccg 3040021 tttctctgac gtcttctaaa gaaatcgttc cgtcttcctg caacggaata tattttaatg 3040081 tggcgccagt tgcttttaca gcctgctgcc acggaatgat attcgcatga tgctccatgt 3040141 aggtgatgac cacttcatca ccaggtttca ggttggcgcg cgcatagctt aacgccacca 3040201 tattcagtga tgtggtcgtg ccttttgtga aaataatctc agccattgac ttcgcgttaa 3040261 taaacttgcg gactttttca cgcgctcctt cataaccatc tgtcgctctg gttccaagtg 3040321 tatggacgcc ccggtgaaca ttggaattgt attggttata atacttatcc agtgtttcaa 3040381 tgacagcacg cggcttctgg gaagtcgccg cgctgtcgag ataaacgaga tcatgtccgt 3040441 tcacttgctg atgaaggatc gggaactgtt cacgaatatc tgtgatattc attacttcac 3040501 tttcctttcg ataacagaaa ctaattgttt cttaacgcct tcaatcggaa gttcatttac 3040561 taccggtgca aggaatccgt aaatgactaa gcgttctgct tcttctttcg gaattccgcg 3040621 gctcatcagg tagtaaagct gaatagggtc cacacggccg acagatgccg catgtcctgc 3040681 agttacatcg tcttcgtcaa ttaaaagaat agggtttgcg tctccgcgtg ctttttcgct 3040741 aagcatcagc acgcgtgatt cttgctccgc attcgcttta gaagcgccat gttcgatttt 3040801 gccgattccg ttaaagatag aagaagcgga atccttcatc acaccgtgct tcaagatata 3040861 gccttcagaa gctttaccga aatggatgat ttgtgttgtg aagttttctg tttgctctcc 3040921 tcttccgaca acaaccgttt tcgtatcgcc gtatgtgccg tcaccgtaaa ggtttgttgt 3040981 gttttcggaa atcgtgtcgc catcgttcat caggccgaga gcccactcga ttttgctgtc 3041041 gcgtccgcgc gcagcaccgc ggcggttcac ataagttgtc acaccgcttg acagattatc 3041101 caccgcaccg tatgtcacgc tggcattatc acctgtgatg acctcactga taatattgaa 3041161 gacagcgtct ttcgggttta cagtgctgat gtagttttct acatatgtta cagagctgtg 3041221 gtcttcagcc acaatcagca cgtggttgaa tagagctgta tcattgcttt cgtggacata 3041281 aacagcctga accggcgtct ccacctgaac atttttcgga acataaagga atgctcctcc 3041341 gttaacaaga gccgcgtgaa gtgcagttaa cttatgttcg tcaaccttca cgccgtcctt 3041401 cataaagtat ttctccacca agtcgctgtg ctcgcgtgca gcagtcagaa tatcagtgaa 3041461 gatgacgcct ttgtctttca attcttgaga aagagaaaga tgtgccggcg tctggtcacg 3041521 ctgtacgtat aatgttttat cttcgttttc aatgtcgatc agcgctttta cttcatcagt 3041581 caaatcttct aatgaagaaa gcggttcgtt atccactgta tgcttcgcga aattcgtgaa 3041641 gttccagttt gtgatttttg ttttgtcagg tttcggcatc ggcagatcct cagcttgttc 3041701 aagagcctgt aagcgcaggt tcttcagcca ggcaggttct tggtgctttt cggaaaagct 3041761 tttgagatac tcctgatcta cggatagttt tgtacctagt gtcatattaa tccccctaac 3041821 gcttacgctt cttggccaac agtttcgtct tcaatgccaa gttcttgttt gatccagtca 3041881 taaccttctg cttcaagacg ctgtgcaagc tctgcaccgc cggattttac aacgcggcct 3041941 tgcatcataa cgtgaacaac atccggagtg atgtagttta acaggcgctg atagtgagtg 3042001 atcatcaggc agccgaagtt ttcgctgcgc attttgttga tcccttttga tacaactttc 3042061 aaagcgtcaa tatcaaggcc tgagtcaatt tcatcaagga tggcgatttt cggttcaatc 3042121 atcattaatt gaaggatttc gttgcgtttt ttctccccgc ctgagaagcc ttcgttaaga 3042181 tagcgctgag ccatttcagg gtccatttca aggaactcca tgttttcgtc cattttgcgg 3042241 atgaatttca tgagagaaat ttcatcgcct tcttctctgc gcgcgttgat tgctgagcga 3042301 aggaagtcgg catttgtcac accgctgatt tcacttgggt actgcattgc aaggaataag 3042361 cctgcctgcg cacgctcgtc cacttccatc tccagtacat ctttgccgtc aagcgtgatg 3042421 ctgccttttg ttacttcata tttaggatgc cccataatag cagctgataa agtggattta 3042481 ccagttccgt tcgggcccat tactgcgtgg aattctccac cttttatttc aaggtttaca 3042541 ccctttaaga tctctttccc ttcgatttca acgtgaagat ctttgatcgt taatgttgaa 3042601 gcagccatat ctatacctcc aaaaatatat aatcattatt ctcattttat tctcattcta 3042661 attttataac aaatgaaaag taaatacaac tttttatcgt gccttgcaca ttcctcaagt 3042721 ttaacaaaga tcagcacttt attaaagcga ttgaaaaaga aaaagagtgg attcccaccc 3042781 ttttttaaaa gattgatttt ctcaataagc tcccgcagaa atccgcttgc ttttttcata 3042841 atcaagctct ctctgccgct ctactttcat tcttgtttcc agccggcgtc catattcctc 3042901 gtatccaatt ccgtgtgaca gctgcatcgc tttttccatt tctgacgtat aatcgaggtt 3042961 cagtctgtcc tggctgctgc aaataatgaa tcaatccctt catatatttg ctttttattg 3043021 taccagtgct gcgttggatg ccgcaaaaac gatttggcgt gaaatagcgg cagatgagac 3043081 gaaagcatcc tttcagaaca aatgagaatg gtttttcgga atattccttc tcttaatgcg 3043141 tggtgtttcc gaattcctca atgcactgtt gaacgactgt cacgccttgg ctgaaagctg 3043201 cgccgcctcc aaatgccgct gccacactga cggcttcgag aatgttttct tctgacgctc 3043261 cctgatcaag acagcctttt gtatgataga tcatgcaata ttcgtcctga gcattgatgg 3043321 caattccgag ggcgatcagc tgtttttctc tttcagtcag agaattcccg gcaaagcact 3043381 gttcagtaaa ttcgttaaat tttcttccca tcagcggcat cttttgttca aatgtgccta 3043441 aaccatgttt atattgtttt aacgcgtcct gcatgcttcc tctgtcttga ttcaaagaaa 3043501 atccctccat ctgtttaaca ttccttttta ttatgaacag cttttaggaa aatacgcgaa 3043561 aaaaaccccg gaattctcat ccggggtttc agtcttattc agatacagga agcacagctc 3043621 cgtcgtattt tttctcgatg aagtctttga tctttttaga gtgaagaact tccatcagcg 3043681 ctttgatttt tgcagaatct tcttcgcctt ttcttactgc gatgatgtta gcgtatgggt 3043741 tgtttttcgt tgattctact tcaattgcgt cttttttagg atttaattta ttttggatcg 3043801 catagtttac attgatgaag accgcgtctc cttctttgtt ttcatatgct tttgccgtta 3043861 attcaggcgc tacttttttg aattcaaggt ttttcgggtt tttcttaatg tctttcaatg 3043921 ttgcgtcaac tgtttccact ttagaatcaa gagtgattaa tccagcgttt tcaagcattg 3043981 caagcatacg gccttgttca gcaacgttgt ttgtcagaat gattgtcgca ccgtctggaa 3044041 ggtctttcag tgatttgtat gttttagagt aaataccgaa tggctctaag tgaacagcgc 3044101 cggcattcac aagtttgtaa tctgtgtttt ctttcatttc ttgctcaagg taaggaatgt 3044161 gctggaagta gttcgcgtcc acttctttat cagctaaagc tttattgtac attttgtaat 3044221 cactaagcac tttcactttc agcgtatagc ctttttcttt cagcaatggt tcagcttctt 3044281 ttaaaatttc cgcatgcggt gtttttgttg ccgcaacgac aatttctttc ttgccggatt 3044341 cagcgccgtt attcgaaccg caggcagcca taactcctgc aaatacaagc agtaatgcac 3044401 ccaaaaatag ctttttcaat gtaaatcctc ccttatcgtt tgtctataat atttgttatt 3044461 agatcaccga tgatttgaat aataaacacg atgattaaaa taaacacagt agcaacgaag 3044521 gtaacatcag cgttattaga ctgatatcct tctacgtacg caaggtttcc aaggcctcct 3044581 gaaccaatgg ctccggcaat tgccgttgaa ccgattaaag cgatggctgt aaccgtaatg 3044641 ccagaaataa gagcaggcat tgattccgga atcagcactt tgaaaataat cgtagacgtt 3044701 ttcgcgccca ttgatttagc tgcttcaatc acacctttat ccacctcacg cagcgcgatt 3044761 tcaacaaggc gcgcgtaaaa tggtgccgag ccgattacca gcgccggcaa tgcggcgttt 3044821 ggccctaaga tcgtgccgac taaaaatttc gtaaaaccta atagtaaaat aattaaaata 3044881 aggaacggaa tcgatctgaa tatgttaaca acggctgcaa tcactgagtt gaccgcttta 3044941 ttctgccaga ggcttccttt gctcgtcaga aagagcagca agccgaggat gaccccgatg 3045001 acaaaagcaa acagtaaaga aatcagcgtc atataaagtg tttcatatgt cgcgttccat 3045061 aattcagtta aatcaacgtt cgggaagtat ttttcaaaca ttcgtgatca cctctgcttt 3045121 cacctgtttg tcattaatga atcggatcac gttttgcact tcttcctcgt ccccgtcaat 3045181 gtggatgaac agtgaaccgt aagccccatc cttcgtctgc gaaattttcc cttgcagaat 3045241 attgacgctg acattgaagt ttctgatcat ctctgtaatc agaggctgtt cagctgactc 3045301 accgacaaat gtgagctgaa ccatttttcc tgatgctgta tcatcaagaa ggtgctgaag 3045361 cgtctctttc gtttcttccg gctctgtcac ctgttgaaca aatcgttttg tcatttgttc 3045421 ctttggattt ttgaagacat cgagaacctc gccttcttcg accaccttgc cgttttccat 3045481 gacggcgact ctgttgcaga ttttgcgtat gacatgcatt tcgtgcgtaa tcagcacaat 3045541 cgtcaaaccg agtctttcat taatatcgga caatagatcc agaattgaat ctgtcgtttg 3045601 cggatctaat gctgatgtcg cttcgtcaca aagaagaacc ttcggattgt ttgcaagcgc 3045661 tctggcaatt ccgacacgct gcttctgacc gccgctcagc tgggacggat aagatttttc 3045721 ttttccttct aaacctacca gtttaatcag ttcattggcg cgcttgatcc gctcgctctt 3045781 tttcaccccg gcaatttcta aaggaaacat gatattatct ctgacagtcc gcgaccaaag 3045841 caaattgaaa tgctggaaaa tcatactgat ctcatggcgt gcttttctta aaccgcgtcc 3045901 atttacttca ttaatcttgg ttcccgccac ttccacggtt cctgaggttg gtttctcaag 3045961 gccgttcagc agacggatta aggaactctt accagctccg ctatatccta taattccaaa 3046021 aatctcacct tttttaatgg aaagcgagac gttttggaca gcattgacat ctccatgttt 3046081 cgacttgtaa acttttgaaa catcctgaag attgatcaaa gcaatcacct gccttaacac 3046141 tattctaaga aatcttccgg ttttttctgc aaaagaaaag cctttctgca cacttgagca 3046201 gaaaggctta tataaaatgc ctttctctca tctttcaaag ctgaacgctt cgtgtgaatt 3046261 ggcaccattt caacagtgtt gatggttgcc gggcttcata gggcacttcc ctccacctct 3046321 cttgataaga gaaatatata gtctttttcg tccggaaatt cttaatgtag aatagcacgg 3046381 cgaatgatta aatgtcaata aaataaatga tgtcaacttt tactattata ataatttatt 3046441 attttttaat tttttaaaat cctctgaaaa aatccatttg tcagccagag aatggcttcc 3046501 agctttaaca gggccctgaa tgaccccttt actttgaggc ttccgctctg aataaggtgc 3046561 tgaagggaaa tgtctccgtg caataaatca ataatttccg tttggtttcc gtaaaaggtc 3046621 aggttggacg tttggggcgg agaaactttt ttcatttctc cctgttcgtt tattgagacg 3046681 gttaaggctt ctgcttctcc ttggaaggta atgagcaatg ttgaggcatt caaaaggggt 3046741 tttaaaaaca gatgctgata ctcatcttct aaaacttccg ctttctccat atgtacaacc 3046801 tcctatttgt tggtcataca tacacatttc tctctttgtc gcaagaaccc ctttataaaa 3046861 cgaacgacaa tttcattgga tatgctgaga aatatgtcat aaatgggatg cggaagatga 3046921 tttttgtttg atcagctcat ataaataaga aacggaatga aatgcatatc ctctttcgac 3046981 catctttccg cctttaaaca gcagaaaaca agggacgctt tcaatttgat acgcttttgc 3047041 gaatgtcgga gagtaattga cattgttttg atagaaggcg acatccggca gcatttcttt 3047101 caccactgtc agcattttgc ttgcaagctg gcaggtgccg caaaacggag tatataaata 3047161 tagaaggtac acatcatctt caatgtgatc aagttcgtgt tcttggagtt ctttcatgct 3047221 atacacctcg ggactttctt tcaagaaaaa tagtatggac attcagattc gcacgcagca 3047281 atacagaagc gatatggtgc ctgggcgcag ccgctacttc cttataggct ctgtcgacat 3047341 ggagatggca ggcttcatta aattcacgct tcagctgttt tctcaatttc tcacctgatt 3047401 catcagcatc aactaatata tagacgtctt tatcataaag ctcgtcagcc aattcctcga 3047461 gcctcagctg gctgattgtt ccgtttgtgc agataatgcg catcggttca ttcaggacgc 3047521 tttcgatttt ctctttatct gatttcccct cgacaatcat aaccttttcc agctcatcca 3047581 tcttcatctt gttcacctgc cgcgtcaaat ttgaaatgtt cagattgtaa aagaaggcag 3047641 tgaaattcac cgccaacatt aacaccagcc gttttcgtag tcacaatcta catattttgc 3047701 gtcgtctcca gagaccacat cggctgtctt ataaaatttc tcattttcaa aggaataacc 3047761 ggacttaagc tcatattcat tcatgcttgt catttggccg atcatctcat tatcatgata 3047821 taacgagagc cggccatttt gaaagcggcc tgtcacgtca ttggtgacat cgagcttttg 3047881 tttgtcgaaa gccatattgg acacctccca taacgttagc gtgtccaatt gcttttacgg 3047941 ctatcctgtt ttagtcttct tgtgtcatct cttcgtattg ctctgctgtc atcagttttt 3048001 caatttcaga agcgtcagat ggctcaacga cgatcatcca tgctttttcg tacggagatt 3048061 cgttgacgaa ttccggactg tcatcaagat cttcgtttac ttccacaacc gttccgttaa 3048121 tcggtgcata aagctcagat accgttttaa cggattcaac actgccgaat ggctcgtccg 3048181 ctttgatttc agcgcccact tcaggaagtt cgacaaacac gatgtcgcct agttcggact 3048241 gggcaaaatg cgtaattccg attctggctt tttctccttc aacttttacc cactcgtgtt 3048301 ctcctgagta acgcaaatct tttggtatgc tcaattgaat ccctccattt tttacagcac 3048361 tacaataaga agataccaca cttttcaaaa aaaatttaca ttaagcccag ttttcttcaa 3048421 attggtcttc tttaaatccg acagtcactt tttcgccgtc tgttgtaagc gggcgtttaa 3048481 ttagcatacc atctgaagcc agcagttcga gctgttcgtc ctctgacata tgatacagct 3048541 tttccttgag attgagctcg cggtatttca tgccgctcgt gttgaaaaat ttcttgagat 3048601 ccagcccgct tttttcataa agcgctttta attcttcttt gcttggcggc tgctcagcaa 3048661 tatgtatttc gtttatttct ttcccatgct cttcaagcca cttctttgct ttgcggcacg 3048721 ttccgcattt agggtaccag taaaaagtta acgacatctt cttccccctc aataaaataa 3048781 tcgaggttat tttaacacag tttgttttaa aaacctaaaa cagtgcttct taaaaaagag 3048841 ctccgcgcat gcggagctca tggccaatca gacagtatat ttctcagcct caaaaatgcc 3048901 tgccgccgcc tcgcgttttt tctgaatcac gtttttaggc gttacgcgtg tcagcttgcg 3048961 cagagcggaa agcatcatgc ggagtgaatc tccttcttcc attgcgataa gggattcctt 3049021 tgcatgcgct tcgatttcgt taaaggcctc ttgaacgaaa atttctgtgt acagcacctt 3049081 ttgcgctgct ttttcagcgc cttgtgcggc aatggccttt tccgttctga gcacggctga 3049141 ttccattgcg tatacattgc tgacgatatc cgctacgttc acgagaattt cttgctcacg 3049201 atcgatcgct tttccgtatt tttgcgcggc taggccggca gcaaacaacg caattttttt 3049261 ggcttgcttg acgatatatt tctcctgctc taagacgccg cttccaggct cttcaggcat 3049321 aagcatcatg agttcttcct gcagcgactg cgctttttcg aataaaggca gctcgccttt 3049381 aagcgctttt ttcaggaagg tgcttggcac gattaaccgg ttgatttcgt ttgtgccttc 3049441 aaaaatccga ttgatccttg aatccctata ggccctttct acttcgtatt cctgcataaa 3049501 gccgtagcct ccatgaatct gcacgccttc atcaacgata taatcaagcg tttcagagcc 3049561 gaatacctta ttcagagagc attcgatggc gtattccgca atcgatttgg cgatttgccg 3049621 gccgtccttg agatcttcgg ccgtgaactg gctcatattg tcttcaaaca gcccgacggt 3049681 tctgtataca gagctttcca tcgcatacag ccttgaggcc attgtcccga ttttttcctg 3049741 tgtcaatgaa aaaccagcaa tcggcgtttt aaattggcgg cgctgatttg cgtatgccgc 3049801 agacagctcg atgacgcgtt tagatgcgcc gattgtgcca accgccagtt tgtaacggcc 3049861 gatgtttaaa atattaaagg cgatgacatg ccctttgccg atttctccga gcaggttttc 3049921 ctttggcact tcagcttgat ccagaatgag ggttcttgtc gatgatccct tgattcccat 3049981 tttcttttct tccggtcccg tggagacacc cgggaactct ttttctacaa taaaggctga 3050041 aaacttgtcg ccgtctacct tagcgtaaac tacaaataca tcggcaaaag cagagttggt 3050101 aatccactgt ttttcccctg ttaatacata atgggttcct gcttcattca gcacagctgt 3050161 tgtttttgct ccaagtgcat cagacccaga gccaggctca gtcagagcat aagcggcgat 3050221 cttttcgcct gaagcgagtc caggcaaata ttttttcttt tgttcttctg acccgaaaaa 3050281 gacgatcggc aaggaaccga taccgacatg cgcgccataa gaaagagaaa agcttcccgc 3050341 acgcgaaaat ttctcagtga tgagtgccga gctgatttta tcaaggccga gcccgccgta 3050401 ttcttccggc acatcggcgc caagcagccc tagttcgccc gctttcttca acagtctgac 3050461 agaatgctcg aattgatggt tttcgatatc atctatatga gggagaacat cttgctcgat 3050521 gtaatcctct gttgttttcg caatcatttt atgctcgtca gtgaaatcct ccggtgtata 3050581 catttgatcg tatgtgacat cctcgattaa aaatccgccg cctttttgta cgtcagccgc 3050641 tttttttgcc atttgttttt ccccctttag cataattcaa atacaccggc cgctcccatt 3050701 ccgccgccga tacacatggt cacgactcca aattgctcgt ttctccgttt catttcatgg 3050761 atgagtgaga gtgtaagctt tgtgcccgta cagccaagcg ggtgtccaag cgcgattgcg 3050821 cccccgttga cattcacttt ttcttcatca attcccaatt ccctgattac ttgaatggcc 3050881 tgtgaggcaa aagcttcatt cagttcaaac aagccgatgt cctgcagctg aagtccggca 3050941 agcttcaaag cgcgcggaat cgcttccacc ggtccgattc ccatcacttc cggcggcacg 3051001 ccgcctaccg caaaggagcg gaatttcaca agcggcgcca ggccaagagc atcggctttt 3051061 tcccggtcca tcagcatgac agccgccgct ccgtcactcg tttgtgagga attgcccgca 3051121 gtcaccgtcc cgtcaacgga aaaggccggg cgcaatgtcg ataagatgtc tgcagtcgtt 3051181 tgcgggcgaa caccttcatc ctgagaaaac acaaactgtt tttccatagg cttatggtct 3051241 tctccgattt ctgtcaccgt cacttcgacg ggtacaattt catctttaaa ttttccttct 3051301 gcaagggctt tagcggcgtt ttgatggctg cgaacggcaa acgcgtcttg atcctcacgg 3051361 gagacgccgt attttttcgc gacttgctcg gctgtgtgcc ccatgctcat ataatattcc 3051421 ggtgcctttt ctgccaaagc aaggttcgga cgggtaacat gccccatcat cggaacttgc 3051481 gacatggatt ctgctccgcc ggcgatcgct gtatcgtagg cgcccagcat aattttttct 3051541 gctgcatacg caatagactg aaggcctgaa gagcaatagc ggttaactgt aatcgccgga 3051601 accgtgtacg gcaggcccgc gagcgcaccg atatttctcg ccatattaag cccctgctcc 3051661 gcttcaggtg ttgcacagcc gataatcaag tcatcaatat tgccttcgta gccgcctgcc 3051721 cgtttcagcg tttcttttac acaaatcgct cccaaatcat ccgggcgaac ggtggccaac 3051781 gatccttttt ttgcttttcc aaccggtgtt cttgcacctg acacaatgac tgcctctttc 3051841 ataagctccc tcctaattcc gtaaaggttt acctttcaca agcatatgct gcattctcgc 3051901 ttgagatttt gcctctcctg acaaactcaa aaacgcttct ctttcgatct ccaataaata 3051961 ctcttcatca acctctgtac caaacggcac ttttccgccc gcaatgacat aagcgagttt 3052021 tttcgcgatc ttaaaatcat gctcagatat atagccggac agcttcatct gctcagcgcc 3052081 aagcaagagt gccgcataac cggtttctcc cggcaccttg accttttctt ttacaggcgg 3052141 ccgccagccg gtatcgtata aagatgcggc cagctgcttc gcatcgtata acaggtggtc 3052201 ttgattcacg ctgatctgat ccgtttcttt taagatgttc atctcacgag cctcttgagc 3052261 ggaagcggac actttcgcca tcgcgattgt ttcaaatgtt ttcattgccg cattcatcgg 3052321 atcatggccg cggcgaagat ggttgatgta cagctctttg ttacctcctc cgccagggat 3052381 gaggccgaca ccggattcca caagtcccat ataggcttcg cttgccgctt gaatgcgcgc 3052441 cgccggcagg catgcttccg ttcctccgcc gagcgtcatg ccaaatggcg cggcgacgac 3052501 cggtttcgca ctgtatttga tcttcatcat cgtctcctga aaacggcgga tcacaaaatc 3052561 aacttccaaa aagttgtcat cttggacttc cattaagatc atggcgagat tcgcgccgac 3052621 gcagaaattt ttcccttgat tgccgatgac aagccccttg taattccgtt ctgtttcctc 3052681 taatcctttg tggatcattt gaatgatatc gaggccgatc gcattgcttt tcgaatgaaa 3052741 ttcaagaagg gccacatcat ctccaaggtc aattaagctt gctccgctgt ttttcgcaat 3052801 cacgcctttt gtttctttaa gtgcttgtaa atgaattcgt tttttgtttt ctttcacggc 3052861 tctgtattcg ccgcggtcat aataaaatac cgttccgttc tctttgatgt agaaggtttc 3052921 atttcctttg tccagcatct cttttatcca gccaggcata tctgctccaa gctgctcaag 3052981 cttttccgct gactgcttga ggccgatggc gtcccacatc tcaaaaggtc ccagttccca 3053041 gccgaatccc cacttcatgg cttggtcaat cgcatgaata tcatcggcaa tctcgccaag 3053101 cagctcggct gagtaaagca gggtttgaga agtgatattc cacagcaaac ggccggccct 3053161 gtcatccgaa taaataagcg ctttcatttt ggcttttgtc ccttttgcct gttttgccgc 3053221 ttcaagtgcc ggtgatttca tttttgtccg ctcgccgtaa gtaagcgtca ctgggtcaag 3053281 ctcataaatc gtttttcctt cttttttata aaagccttgg ccggccttgc ttccgatcca 3053341 ccctttttcc agcatatcgt tcatgaagct tggaatgcga aacacttctt tttcatcgcc 3053401 atcagctttg tcatacacat ttcgggcaac gtgggcgaat gtatcgaggc cgaccacatc 3053461 aagcgttcta aaggtggcgc ttttcggcct gccgatcagc ggtcctgtga tcgaatcaac 3053521 ctccccgacc tgataaccgc ctttcagcat ttcttggact gtcacgagaa gcccgtaagt 3053581 cccgatgcgg tttgcgataa agttcggtgt gtcctttgct gtaacaacgc ctttcccgag 3053641 gacattttct ccgaaagctg tcataaactt taaaatatca ggatccgttt ccttaatcgg 3053701 aatgatctct agcagcttta aatatcgtgc gggattaaaa aaatgcgttc caagaaaatg 3053761 ggctttaaaa tcatccgacc ggccttcagc catttcctgc actgatatgc cggatgtgtt 3053821 gcttgagacg atgcttccag tctttcgatg ttcatccaca agagcgaaaa ttttcttttt 3053881 gacttcaagg ttttcgacaa cgacctcaat aatccaatct gcttctttca gtttttctgc 3053941 atcatcctcc agattgccag gtgtaatata ggaggtattt ttcgctgatg tgaggggagc 3054001 gggcttttgt ttcagcagtt ttttcatcgc ctgccggctc agcctgctgc gcacctccga 3054061 actgtccttc gtcagcccct ttttttcctc ttcctttgtc aaatcgttcg gcacaatatc 3054121 tagcagcagg acaggaattc cgatgttagc caaatgcgcc gctatcccgg aacccattac 3054181 ccccgatcct aaaacggctg ccttccgaat gtgtttgtgc atgagatatc ccccttgaac 3054241 attgaatgaa tagtcattca ttttttgact aaaaaaaatg aaacccgttt cttctttcat 3054301 cttaaaagat ttccggttcg acttcaatag ctaatttgtt atttttttgt atgaagccta 3054361 taaaagtcgg gcaacttaag cccggaggtg aagggaatgg tacgagagaa aaaaaatccg 3054421 tcttcagcgg cagtcagcgc ggcgagcgta aagggagatg ccggtccgac tcagcattac 3054481 ggcggcggaa aacggacaag tcaaaatcag cagtataaaa aacataacat gggacaatca 3054541 taatgcagct gcttcccacg gctgctttca ctttttcaaa attcctttta acacaaacgc 3054601 tgcattggca ggccgttcgg caattcttct cataaagtag ctgaaccagt ccgttccata 3054661 tgggacatac acacgcattc tgtagccttc cttggcgagt tccttctgac gctccggcct 3054721 gatgccgtat agcatttgaa actcaaattg cgatgcgggg atttgatgtt cggcgacgag 3054781 ctgtttcgta aatgcaatga tgtcatcgtc atgtgtggcg acagccgtgt agttcccgct 3054841 taacaactgc agctttatta agctctgaaa atgaaggtcc gtgcctcttt tgtcgggaaa 3054901 cgctacagcc gcagattctt tataagcgcc ttttacaagt ctgagattcg gctttaagtc 3054961 ccgcatcttt ctgatatctt ctgccgcccg gtacaaatac gcctgaatga ccgtgccgag 3055021 cttctcaaat tcctgtttgc attgcctgta aatagaaagt gtctgttcat aatgagaata 3055081 gtcttccata tcaatggtca cagcaacatc atattgcttc gcaacggaaa gaatggcgcg 3055141 caaatgagta agagcaagtt cttctgaaag atcgagcccg attgaggtca gcttaagtga 3055201 aagctctgaa ttcaattgat gttcggcaat ggcttgaatg gctttcttgc attcctctgc 3055261 gacttggttt gcttcttttt ccgaagctgc atactcgcct aaataatcaa ttgttgcaca 3055321 caaaccggat ctgtttagcc ttttgacggt cttaaccgcc gattcaatcg tatcccctgc 3055381 gacaaacctt cgtgctccaa gccgcgttcc gtatgctttt gcgaacttgg taagtgtttt 3055441 attttgagat aagaataaaa acacatgtct caacatccga ctccctcccg ccgtcatctt 3055501 caaaacacct gtatataact cccagtctga aggaaactat aaaatgaaca gaaaccaaag 3055561 gaggatcaca atggataatc agcagcaatc tcaaatgccg ccttccgtta tttcgacaaa 3055621 ggatcatttg tatctcaatg acatgctgaa ctggaatttg ctcgcgatga aaaaagcgca 3055681 tttcatggcg cagcagtgcc aggatcaaac gttaaagcaa gaactcgacc gcgtcggaca 3055741 catgcatcat gatcactatc aaagaatatt aaagcacctg cagccaggcc agcagcagtc 3055801 cggctacatc caataaggag gcgccagaat gaatcagcaa aatcaaaaaa tcagcaaccc 3055861 gcagacacct gtaccgacaa catcggaaat gaatgacaga gatttcgtca acgaattgct 3055921 gacaaccgaa aaatacatga caacagctta ttgcactgcc ttgcacgaat tcagccacga 3055981 gtctctttat caggatattc aatccatttt tgatgagtca caaaaagcgc aaagaaaact 3056041 atatgatctc atgttccaat atggatggta ttctgttgaa gcggaggatt cacaaaagct 3056101 gcagcagtcc tatcaaaaat tccagcagac cattcagcag cagtctcctt atcagcaata 3056161 acaacattag taaaaaggat acgatgttct ttcgggcatc tatccttttt ttgtgtaaaa 3056221 tcagttgact tttcatttac gcttatttat atttaataag cattaactat tttgtcatta 3056281 aaatatatat acagtgtatg taacagaggg gaaatgaata tgaagagtgc ggatcagtta 3056341 atgtccgata ttcaattatc gcttcaggcg ctctttcaaa agatacagcc tgaaatgctg 3056401 gaaagcatgg agaaacaagg tgtcacccca gcgcagctgt ttgtgctggc cagcctaaag 3056461 aaacacggca gcctcaaagt ttctgaaatt gccgagcgta tggaggtgaa gccaagcgcg 3056521 gtgacgctga tggcagatcg ccttgaacaa aaaaatctta tcgccagaac acacaacaca 3056581 aaagacaggc gagtgattga tctcagtctt actgacgaag gagacataaa gttcgaggag 3056641 gttttggcgg gcagaaaagc cataatggcg cgctatcttt cctttttgac ggaggaggaa 3056701 atgctgcagg cggcgcatat tacagcaaaa ctcgcacaag cagcagaaac ggatgaaaag 3056761 caaaacatga aaagaggaaa cggatgaaaa tgagtaaaga aggcaaacaa tcaaaacgaa 3056821 cgttattaat aacaggctta attattgcca tgtttttttc agcccttgac ggtaccattg 3056881 tcggaacggc catgccgaaa attgtcggtg atctgggcgg tttgagcatg atgacctggc 3056941 tgacaactgc atatttgtta acatcaacaa ccattgttcc aattgccggt aaactggctg 3057001 atttattggg acgccgcatt gtctatgtat caggtttgat tatttttatg gccgcttctg 3057061 ctttgtgcgg aatggccaac aacatgacgg aattgattat cttccgtgga ctgcagggca 3057121 tcggcggagg catcatgatg ccgatggcga tgattgtcat cggtgacttg ttcacaggaa 3057181 aacagcgtgc taaattccaa ggtgtctttg gcgcaattta cgggctggct tcagtgattg 3057241 ggccgcaaat cggcggctgg attgtagact cgttaaactg gaaatgggtt ttctatatta 3057301 acctgccagt cggaattatt gcggttattt ttattgccag gggattacag ggacgccagc 3057361 agactggtcc gatcaacttc gatatcgctg gtattttcac aatgattgtc ggtgtggtca 3057421 gcctcctgct cgccttaagc tttggcggaa aagattatgc atgggattca tggcagattc 3057481 ttgggttgtt cgctctcgca ctgatcggca ttgtcagctt tatcatcgta gaatcaaaag 3057541 caaaagagcc aatcctgcca atgtatttat ttaaaaacag aacatttaca tttctaaact 3057601 tgatcggctt ctttatgagt atcggtatgt ttggcgccat tacgtttgtt cctttcttta 3057661 tgcagggaat tgtcggtgta agtgcgtctg aatcgggtac aattatgaca ccgatgatga 3057721 tttctatgat tatcacaagt atcatcggcg gacagcttgt ttataaaatt gggattaaac 3057781 cgcaaatcat tacaggcatg ctggttatgg ccggcggatt cctgctgtta acgacattgg 3057841 atctcgacac gagcaagctt gtcgctacat cttttatggc gattattggt ctgggaatgg 3057901 gtcttgttat gccgattctg acattggctt tacaggaaag cttttcgaag gaggagcttg 3057961 gagttgtcac ttcatccagc caattcttcc gttctatcgg cggaacattc ggcattacca 3058021 tgctgggagc cgtaatgaat gcgagatcag gaaatctatt aacagataaa ttggttccat 3058081 atttagactc tcttccggca caggcaagct cgtttgccgc ccagctaaag ggtatgattg 3058141 atacaaatcc gcaagggctg ctgcaatcac tgttcagtcc ggacgcggtc aaacaaatcc 3058201 ctgcggcttt ctcatcccat attgtgccga ttttaaaaac atcgttgatg gattcgctcc 3058261 acagcgtgtt ttatacgggc ctgatcttta tcgcagtcgg agccgtattc accttgttct 3058321 taaaacctat caagctatca aataagaaag cggaagacca acaagaaaaa gagaaggcgg 3058381 caaaagccgt tgaatcacct tcccattaat agagcacccc gcgggtatca atccgcgggg 3058441 ttttttattc aatcatctgg gctcttccat ttccgaaaga ccaatcctca tcctgatttc 3058501 cggccagcat gataaacaca tcttcttttc ttacaccaag ctcggaatga atccggctcg 3058561 cgattgagcg gtaaagtgct tttttctgtt cagttgttct tgactgtttc agtgtaaaat 3058621 gaatgtatat cagttcatca gtacgctcga cttggagata aaatggatca taaaaaaatt 3058681 cgcttttttc atattgtctg atgacttgga aatagtcatc ttccggcaca ttgatttctt 3058741 caatcatcga ttggtggata gtcctgctca gtttttgaag ccacacttcg cttcttcccg 3058801 accgtaaatg aatctgtaca aatggcatct ccccgcatcc ctttctttac agcgtctgtc 3058861 cgctgtcaat tgtgataatt tggcctgtga gtgattcctg ttcaattagt gaacaaatca 3058921 atttggcaac atcatctggt tcagcaatac actgcagcag caaagagccg atcatgcttt 3058981 tcattttttc ttcccgtccg gcccaccatc tcgttgccac agctcctggt gctacaccgc 3059041 tcactctgat ttcaggcgct aaggcgtggg ccaatgattt cgttaaaccg tgcaccgctg 3059101 attttgatac tgcgtaaggc attgatgagc cggcaccagt tatccctgcg atgctgccga 3059161 cgtttacgat cgccccgtcc ttgcttttct tcatgaacgg aaccactgcc cgcgcgcaga 3059221 aaaacatccc tttcacattg acggcataca gctcatccta gacgtcttct gtcgcagcct 3059281 caagatcatc cattggaata tgccgtgtaa tgctggcatt gttgactaaa atatcaaccg 3059341 tgccgtgtgt gttcacgatt gcttgaatca tatcctgcac gtcgctgttt ttggatacat 3059401 ctgcttggat ggcgaaggct tgcccgccag ctttttgaat catttccact gtttcctccg 3059461 cttctgattg cgagcgtgaa taattcaccg ccacaatcgc cccacgcttt gccaattcca 3059521 tactggctgc ttttccgatt cctgtgccgc cccccgttac gagagctatt ttgttcaaga 3059581 cattcattgc cgccactcct tgctgttgac taaagtatat ttctgattcc attgtaatcc 3059641 agctttgatg ttacgtataa tgattgttaa agatactaga tatcactcag attgatagta 3059701 aacgaacgga ggagttcaaa atggaaagcg gagatttacg tgtgtttcaa atggtagctc 3059761 gtgaagggac cattacgaaa gcagccctgc agcttggcta tgtacaatcg aatgtcacgg 3059821 ccagaattca acaattggaa gctgagctgg gtaccacact gtttttgcgc cataatcggg 3059881 gcatgacact ttctgcaagc ggaaaattgc tgctggacta cgcaaataaa attataggcc 3059941 ttcttgatga agcgtctaaa gcgctctcat cctccgcaga accaagcggg ccgcttatga 3060001 tcggctgcac tcagacaacc gccgcggtaa ggcttccaaa gcttctggca tcttattatg 3060061 aagaacatcc aaacgtccag ctgtctttaa caacaggaca tacgcaattt ctccttgata 3060121 aagttcttcg ttatgaattg gatggcgcgt ttatcggatg cgaatgccat catcctgagc 3060181 tcgaatccta tcctgcgttt gaggaagaac cagtagttgt ttcggctgcc tccgtgcccg 3060241 atgttgagga agccatcaca aagccgattc tcgtttacag cacaggctgt tcgtatcgag 3060301 aaacacttga aaaatggctg cgttccgtcg gtgtcacaca gccggtcatt atggaatttg 3060361 ggacgcttga agcaattatc ggcggggtta cagcaggtct tggcatctcg ttgctgccaa 3060421 gaacggttgt gcagaaacat gaagcagaag gatcaattcg attgtacccg ctgcctgaag 3060481 ctctcagcca gatgaaaaca gagtttattg ttcgaaaaga ttcgtttatc agcagcgcgc 3060541 tgagaacctt tatggattcc tttacgccag ttaaaacggc tgaatcacaa aaaagcagtc 3060601 tgctataatg aacagactgc tttttggcta ttgtttgttt cgatgcgctt catttaattc 3060661 cttaatatgc tgaatgatct ctttaatgcc ctgcttcgcg tcggggtatg tcgcattcca 3060721 atgcttagcg agcggaggca tgcttttggc tatatgggtg tacaaaatcc attgcttcac 3060781 ttcttctttt agctcatcgt ttgtttcacc aagcagaagc tcagtatact tctccagcaa 3060841 tccatcaagc tgctcctgaa gtttttgttc cattttccat cttcctttcg aaaaaacagc 3060901 aaggagcttt ctcaattgaa agctccttcg ctgcgttatt tatccatgtg atgtgaaagc 3060961 cgcttcctgg acaatgcatc tgcccctgcc atgaggaatg caaagaggcg ttccgaagag 3061021 cgggtcctgt gtaacctgac agttcataga aaacacattt tgcacaagat cacaagtgat 3061081 gacctcttcc ggacggcctt ctgcataaat ccgtttatct tttatggcca caagatgatg 3061141 cgcatagcgg cacgccaagt ttaagtcatg gagaaccata acaatcgtcc ggtcttcctt 3061201 ttcattcagc tcaaacagca aatcaagaat ttcaatttga tgcgtcatgt ctaaatacgt 3061261 cgtcggctcg tcaagaagga tgatatccgt ttcctgggca agcgtcatcg cgatccaagc 3061321 ccgctggcgc tgtccgcctg acaaagaatc aacggcacgg tcagccatgt cctcaagctt 3061381 tgttgcttta agcgctcttt caactgcttc ctcatcctct tttgaccact gcttcagcca 3061441 gttttggtaa ggatatcttc cttgcttcac cagctgatgc accgtcagcc cctctggagc 3061501 cgaaggacct tggggcagga ttgcgagctc ttttgcgact tccttcgtcg gaagcttggc 3061561 aatcgctctt ccttccagca gcactgaacc gcctctcggc ttcatcaggc gcgctaatga 3061621 acgtaaaagt gtcgattttc cgcagccatt gctgccaata aatacggtaa tttcaccttt 3061681 gggaattgtt aaattcaact catcaataat aacggcatcc ccgtatccta agctcagcgt 3061741 ttctgtagaa attgcactca tacccataac cgctcctttt tgctggcttt ttagcagcac 3061801 tatgtattgc acgttttcta tatacatgct tttaagtcaa ttgtcatcaa tgcaaatgat 3061861 tccgatattc agccatttga tatggtcata tatccctcat tgtagcagaa aacactgact 3061921 ttgaaaatca ttttcaatta gttttatgga cataattgac gtttatgggt tttttatcac 3061981 aagattactt cttgatttct ctgatggagc cgtccttcag cttcaatttt aaatcgatat 3062041 gatcataatg actgtccaga ttaaatgctg ccagcacact gtgtatcact tctgtttcag 3062101 ccatttggtc tgtcacggaa agctcgctca aaatcatttt catctcatct aacgcttctt 3062161 ctccttcctg attgacaccg gagagcttat cctgtatttc cgctttttcc tgagtcccgt 3062221 tctttgtata gattccttca taacggttat gctcaccatc cccgtagctc acacgaagcg 3062281 aaaaattact gtagggaacg gacttcagct gggtgacggc tgtattttct ccttctgcct 3062341 gatgctggtc ttcattgaaa cggcagcccg caatcagaac cactgcgaga catacagccc 3062401 cggctgctct gatcaaatgc atatgtttcc cccctgtagg attccattta ttttaggtat 3062461 atccagagaa tgaaatcctc attcagagaa gaattgaaaa agccggggca tttaacgcca 3062521 cggctttttc tttaagattc ggtcatttgt aaaaaggttt cggcgtcacg cacagccagc 3062581 ttgatggcat tctcccagaa atcgcgcttt gtgatgtcag cgcccaaatg cttcatcgcc 3062641 aaatcctcca ctgtcataga agccgtatcg cgcaatagcg ccatatactt ctcttcgaat 3062701 gtgtcttttt cttcaagcgc caacgcgtaa ataccaagag aaaacaggta gccgaatgta 3062761 taagggaaat tgtaaaacgg caccctcgtg atgtgaaaat gaagctttga tgcccaaaaa 3062821 agcggatgat attcttctaa cgcattgcag tatgcctctc tttgcgcctc ttccatcagc 3062881 tcattcaagc ggctggccgg taccactccc cgctttcgtt cctcgtagaa tctcgtttca 3062941 aatagaaatc ttgcgtgaat gttcatgaag aacgcaacgc ttctttgcac tttatcctcc 3063001 agaagaacaa gcttttcttc cctcgtctcg gcctgctgga cagtcgcgtc cgccactatc 3063061 atctctgcaa acgttgaagc tgtttctgca acgttcatgg cgtaggaacg gtttaacggc 3063121 ctgacgttga gcattgcttc ctgatggaac gcgtgcccga gttcatgcgc aagggtagag 3063181 acatttgagg cgcttcccga aaatgtcatg aaaatccggg attccccgct gtccggaaaa 3063241 ctggtgcaaa agccgccgac tctttttccg ctcctgtctt ccgcctcaat ccagccgtcc 3063301 cgaaacgctt tttcagtgaa tgaggacagc tttttgccaa acgttgaaaa ctggctggta 3063361 atgatatttg cggcttcatc atacgaatag acctttccgt cagaaccgat cggtgcctcg 3063421 acatcgtacc agctgagttt ttcaaggccg agcatggatg ctttccggtt caaaaactga 3063481 acgaacggct tcttgttttc agtgatgacc tgccacatcg tatcaagtgt ttcttttttc 3063541 atcctgttaa tttgcagcgg ttccttcagg acattctccc agccgcgcgc tttataggtt 3063601 tcaagccgga atcccgccaa atgattcagc gtgctgctga aaatatcttg cttgctctcc 3063661 caagcttggc ggaaacgttc atatactgtt tttctgacag tacggtcttg atgatccatc 3063721 atattctccg cctgaccgac agacaattgc ttgttttcac cgttttcctc atacgggatc 3063781 gtcattttcc cgacaaccat attgtataag tcactccaag cgtgatatcc gtccaccgca 3063841 aggtttccga tcagtttttc cttaccgggg ctaagctttt cggcaaccct ctgtcttctt 3063901 tcatttaata tgtaagaaac atcgcgcaat cccggttttg ttaacaattc attccacacg 3063961 tcttgattaa tgtccacaag tttatgatct aatgtaacga gcgacgattg aaaatctgcg 3064021 gaaagccgat tcatgaggcc tgatgctcta tagccttttg atcattgata ttctgggcct 3064081 ggaggcaagc aacaaaagcg ccggcctgct gaagcttgac ggatgtctgt tcgaataaat 3064141 caagcaacgc ggtcagccct tcagcctctt caggcgattc aggcacctga aacgcatcag 3064201 tcctgtcttg aaatgcacgc agactttgtg acagcttctc aatataacct ttgaattctt 3064261 ccgattggct cccgccctta aaaaatgaat caagatccca tctttggcct accccttgca 3064321 gcgccatatc acaaaacccc tttccttctt tcgttctatt atagaacaat tctgaattat 3064381 tgtataaaaa tttctattac aggcgtcatt tcgtgttcag gatagtacaa tagctgtagc 3064441 agtttaatag gagggttagg atgaataaaa aaatagccat cgtgacagga gcgtccagcg 3064501 gcttcggtct gctggcagct gtaaagcttg cccgatcatt tttcgtgata gccacatcaa 3064561 gacagcctga aaaagcggaa cagcttcgag aattggctgc agcacacaat gtgtctgatt 3064621 ctattcacat tacagctctc gatgtcaccg atgaacaatc tatagtctca ttcggaaaag 3064681 ctgttagtgc ttacgccccg atcgatttac tcgttaacaa cgccggaacg gcttatggag 3064741 gatttatcga ggatgtgccg atggaacatt tcagacaaca atttgaaacg aatgtcttcg 3064801 gtgtgatcca tgtgacaaaa accgtgctgc cttacataag aaagcatggc ggcgcaaaga 3064861 ttataaacgt gagcagcatc agcggactga caggattccc agcgctgtcg ccatatgttt 3064921 cttccaagca tgcattggaa ggtttttctg aaagcctgcg tatcgagctg cttccgttcg 3064981 gtatcgaaac cgctttgatc gagccgggct catacaagac atcgatctgg tcaacgtcat 3065041 tatcaaattt tatgtcggtg cctgctgacg attcagccta tcatcaatac tataaaaaga 3065101 tcctttccta tgttcaaaaa aacggagaag aaagcggaga tccccaagag gttgccgacc 3065161 tcatttatca attggcaaca aaacagcaca taaagaattt gcgatacccg atcggaaagg 3065221 gcatcaagct caccctgctg ttccgatcgc tttttccttg gtctgcgtgg gagtctatcc 3065281 tgaagaaaaa gctattcagc tgatctaaat tataattatt ataatttagt attgattttt 3065341 atttagtata tgatataatt aagtcaacag atcacaagga ggacgttatc ttatgaaaac 3065401 tgaaaacgca aaaacaaatc aaacattagt tgagaattca ctgaacacac aattatcaaa 3065461 ctggtttctt ttatactcta agctccaccg tttccattgg tatgtgaaag ggcctcattt 3065521 ctttacattg cacgagaaat ttgaagaact ttatgaccat gcggctgaaa cagtggatac 3065581 catcgctgag cgcctgctgg cgattggcgg acagcctgtt gccacagtga aagaatacac 3065641 tgagcatgca tctatcacag acggcggaaa cgaaacatca gcatcagaaa tggtacaagc 3065701 attggtaaac gactacaaac aaatcagcag cgaatctaaa ttcgtgatcg gcctggctga 3065761 agaaaatcaa gacaatgcga cagcggactt gtttgtcgga ttaattgaag aagttgaaaa 3065821 acaagtgtgg atgctttcct cttatttagg gtaacaaaaa agctgaacct taatcgggtt 3065881 cagctttttg ttttttctta gcttgaactg ctttctgtct gcttggtcag tgttgcgttc 3065941 aacgttttcg tttttccctt tcgcagcact tggattgttg ttttatctcc gacttttaag 3066001 tctttgtaaa ggatctgacg gatatccgca ctgctttcca cgtctttacc gtttagtttg 3066061 acaatgacat cctcagattt aatacctgct ttttctgccg gcgaatttgc ttgaacttct 3066121 tttacataaa cacctttgcc caattgatct ccaaacaggc cgagcgtatt ttcctgatag 3066181 gtttcaggaa cttgtgacat gtcaatcatc tgcacgccta aaaacggacg gtccaccttc 3066241 ccgttttgca gcagctggtc aacaatcggc tcgacatcat tgcttgggat cgcaaatcca 3066301 agtgattcca cgccgctttc gctcaccttc aagctgttga tgccgatgac ctggccgctt 3066361 gcattgatta atgggcctcc gctgttcccc ggattgatcg ctgcatcggt ttgcagcacg 3066421 ttcatttcca ccgtcccctg tgttgtatcc acatcaattg tccggttcag tccgctaatg 3066481 ataccttgtg tcactgtacc ggaaaactgc tgtccgagcg ggttaccgat agcgattacc 3066541 ttttcgccag tgcgcagctg tgaagagtca ccaaagctcg ccactttttt tacattcttg 3066601 ccgctgattt ccaaaactgc caaatcagta atggtatcgc tgccgacaag cttggcagtt 3066661 tccgtttctc cgttgtatag cgtaacagtc agcttgttcg cgccttcaac gacatggttg 3066721 tttgtaatga tatacgcttt atcgctgtct tttttgaaaa taacacctga cccggttccg 3066781 ctttcacttt ctgagctgga gcctcctccc gtgccgaatg tgttattttg agaggtttgg 3066841 atatttgaga ttccgacaat cgtaggctct aaatcctcta ccatatcagc gatgtttgat 3066901 gcgttcgtta tcggcgccgt tgtaaaatta tcagactgca cctgtttatt tgcggaagcg 3066961 gtttcggtcg cctgattttg gtctgacggc agataaggcg cgatgccaag catgaggccc 3067021 ccgccgataa taccgcctaa aatcgggctc agccatgcgg ctctccgttt cttttctttt 3067081 ttcacagccg tttcttgctt ttccatttct aaagcagaag ccgtttcctg ccgtcccgct 3067141 tcatacgaca caggcgcgtc aagcaattct tgttcagaat gtccaatcag cttctggttt 3067201 tctgtattct gctgttctgt atgtgaaggt tcagtttgat gttgatcgtt ttggccatca 3067261 cgtcgataat ccatgttctt acactccttt aacggttatt catttatcgt tacatattca 3067321 tcgcatgtac aagttcaatt gtcccaataa tgaggagaaa agcaaagcac caaaatagaa 3067381 tatgtttgat catcctacat cttcctcgct ctttttctct tcctttcttc ccttaaccat 3067441 atcataaaca aacattgtgg gataaaaatg aaaagaatat gtgaaattat gaaaattgcc 3067501 tgccgtatgt taaaactagt ttataatgac gttgaaagga tgtgaagagc cttgtcatac 3067561 accatttatc tagttgaaga tgaggataac ctgaatgaac tgctgacgaa gtatttagag 3067621 aatgagggct ggaacattac atcttttacg aaaggtgaag acgccagaaa gaaaatgaca 3067681 ccgtctcccc acctatggat tctcgatatc atgctgccgg ataccgacgg ctatacatta 3067741 ataaaagaaa tcaaggcgaa agatcctgac gtgccggtca tttttatttc cgcccgagat 3067801 gcggatattg acagagtgct tggcttagag cttggcagca atgactacat ttcaaagccg 3067861 tttttgccgc gggagctgat tatccgtgtg caaaagctgc tgcagctcgt atataaggaa 3067921 gctcctcctg tccaaaaaaa tgaaattgcc gtctcctcgt atcgggtcgc tgaagacgcc 3067981 cgcgaggtct atgacgaaaa cgggaatatc atcaatttga cgtcaaagga atttgatctg 3068041 ctgctattat ttatccatca taaagggcat ccatactctc gtgaggatat cctcctaaaa 3068101 gtgtggggac atgactactt cggaacagac cgggtcgttg atgatctcgt ccggagactg 3068161 cgcagaaaga tgcctgaatt gaaggtggag acgatttacg gtttcggcta caggatgatg 3068221 tcatcatgaa aaacaagccg ctcgcgtttc agatatgggt tgtcatatcc ggcatcctgt 3068281 tagcgatatc gattttactg cttgtgttat tttcaaacac gctgcgagat tttttcacta 3068341 atgaaacgta tacgacgatt gaaaatgagc agcatgttct gacagagtac cgcctgccag 3068401 gttcgattga aaggcgctat tacagcgagg aagcgacggc gccgacaact gtccgctccg 3068461 tacagcacgt gctccttcct gaaaatgaag aggcttcttc agacaaggat ttaagcattc 3068521 tgtcatcttc atttatccac aaggtgtaca agctggctga taagcaggaa gctaaaaaga 3068581 aacgttacag cgccgacgtc aatggagaga aagtgttttt tgtcattaaa aagggacttt 3068641 ccgtcaatgg acaatcagcg atgatgctct cttacgcgct tgattcttat cgggacgatt 3068701 tggcctatac cttgttcaaa cagcttctgt ttattatagc tgtcgtcatt ttattaagct 3068761 ggattccggc tatttggctt gcaaagtatt tatcaaggcc tcttgtatca tttgaaaaac 3068821 acgtcaaacg gatttctgaa caggattggg atgacccagt aaaagtggac cggaaagatg 3068881 aaatcggcaa attgggccat accatcgaag agatgcgcca aaagcttgtg caaaaggatg 3068941 aaacagaaag aactctattg caaaatatct ctcatgattt aaaaacgccg gtcatggtca 3069001 tcagaggcta tacacaatca attaaagacg ggatttttcc taaaggagac cttgaaaaca 3069061 ctgtagatgt tattgaatgc gaagctctta agctggagaa aaaaataaag gatttattat 3069121 atttaacgaa gctggattat ttagcgaagc aaaaagtgca gcacgacatg ttcagtattg 3069181 tggaagtgac agaagaagtc atcgaacgat tgaagtgggc gcggaaagaa ctatcgtggg 3069241 aaattgatgt agaagaggat attttgatgc cgggcgatcc ggagcaatgg aacaaactcc 3069301 tcgaaaacat tttggaaaat caaatccgct atgctgagac aaaaatagaa atcagcatga 3069361 aacaagatga tcgaaatatc gtgatcacca ttaaaaatga cggtccgcat attgaagatg 3069421 agatgctctc cagcctctat gagcctttta ataaagggaa gaaaggcgaa ttcggcattg 3069481 gtctaagcat cgtaaaacga attttaactc ttcataaggc atctatctca attgaaaatg 3069541 acaaaacggg tgtaacatac cgcatagcag tgccaaaata gactgtagat gttttgcagt 3069601 ctattttttt atgtgaaaga atagccgtta aaatctctgt aatttgtttt gagcggctgt 3069661 ttgcattgat gaacccattt tttctctgac aaggtctgct tcggatattt gactttctcc 3069721 actttgattc ctctgtttcg caagcggctg atcatttcgt ccaattctct cattctagat 3069781 tcaccctttc gcttgagctt tgaccattcg gtcatctcaa tttataatat aaataataca 3069841 tgataaaaaa acaagttaca ataaggttaa ttttataaca gacggtgtga ctatatggtc 3069901 atatcctagc aggcctccgg gctccgaaag ggtggaacca ttgaaggaaa aagaaaaact 3069961 gattattgaa acagccttaa aactatttgc ccaaaaagga tacaactcaa catcagtcca 3070021 ggaaatcgca aaagaatgca aaatatctaa aggcgctttt tatatttatt ttccttcgaa 3070081 agaagcgctt cttctctcta tgctgaacta ctattatgat aaaacgttta cccgaatttt 3070141 aaatattaaa acgaagggcg acagccccag aacggcttac cgtaaacagc tgaccgtcct 3070201 ctatgaaaac attcttgaac acaaagattt tatcagcatg cagttgaagg agggttctct 3070261 gccttacaca gaagaagtgg agcaatgcgc aaaaaaaatc cgccagtcct cacttcaatt 3070321 tcatatcgac agcctgctga acatctatgg aaaaaaagcg gaaccgtaca ctgctgagct 3070381 ttgtttttta atagagggca tcagccagat ttacctggaa tgcatgattt tgctcgggta 3070441 cactgtgaag ccgtctcaat tagctgatat cattatgaat cgaattgatg atatggtaaa 3070501 aggcatgtct gaacgaaacg ataagccttt catcacattg gaagaggcga gctctttatt 3070561 cggacctctt acgcacggac ggcctgaccc gctgactgaa tcaattgtga aaagcctacg 3070621 tgacaaaatt aacagcttaa acacaaactc ctctcttgaa ttatcggaga gcttggacat 3070681 acttgaagca gaaatgaaga aaaaaacacc gaagctggcg atcataaaag gaatgattca 3070741 taatctgacg gagtctgaag ctctcgccaa agatgcggaa cagcttaaat atttattaaa 3070801 acagcaacat atttagaaga acggctgctt aaaaagcagc cgttcttcct attacgcctt 3070861 tggttttacc atgtcttccg gcttaaccat ttcgttaaat tgctcctctg tcagcaattc 3070921 aagcttcaaa gctgcttctt tgagcgtcaa tccctcttta tgggcaagct tggcgatttt 3070981 cgccgcgttt tcataaccga tatgcgggtt cagcgccgta acaagcatta atgaatttga 3071041 caggttttcc tgaatggttt ctttattagg ctcaataccg acagcacatt tatcatggaa 3071101 tgaattcatg ccgtcactga gcagctgcac agattgcagg aagttgtaaa taataacagg 3071161 cttaaacacg ttcagttcaa agttcccctg actcgccgca aagccgattg tcgcatcgtt 3071221 ccccatgatt tgcgctgcga tcattgttaa cgcttcgctt tgtgtcggat tgactttacc 3071281 aggcataata gagcttcccg gctcattttc aggaatgacg atctccccga tgccgcagcg 3071341 gggtccgctt gcgagccatc tgacatcgtt cgcgattttc attaagtcag ccgcaagcgc 3071401 ttttaatgcg ccatgcgcat aagtgatttc gtcatggctt gtcagcgcgt ggaatttatt 3071461 cggcgagctg ctgaacgttt ggccggtcag cttagtgatc tcttctgaga caagctctcc 3071521 aaactctggg tgggcgttga tacccgttcc gacagccgtt ccaccaattg caagcgcacg 3071581 cattttatct gtcgcttcca aaatcatttc cttcgaacgg tccagcatgt gaacccatcc 3071641 gctgatttcc tgtccgaggg tcagtggcgt agcatcctga agatgcgtgc gtccgatttt 3071701 gacaatatca ttgtatgctt ttgctttttc atccagtgta ttgcgaagct gatcaagcgc 3071761 cggcacaagc tgctcgtaaa cagccaaaac agcggcaaca tgcatcgcag tcgggaatgt 3071821 gtcgtttgag ctttggcttc ggttcacgtc atcatttgga tgaatcgttt gatcagagtt 3071881 cttctctttt aataaagcag tcgcacggtt ggctaccact tcgttcatgt tcatattgct 3071941 ttgtgtgccg cttccggtct gccatacgac aagcgggaag ttgtcatcgt acttgccttt 3072001 gagcacatca tcacaaaccg ctgcaatcgc ttctgctttt tcagcgtcca gattgccgag 3072061 gcgtttatta gctagagcag tgcttcgttt taaaattgca aacgccttca caacacgcat 3072121 cggcattttt tcagaaccga tcttaaagtt ctccttgctt cgctgtgttt gggcgcccca 3072181 aaatttatca gcaggaactt ttacttctcc catggtgtct cgttcaattc tgtattccat 3072241 ttatgtatcc ctccataacg gttgcttcaa tagatcataa ttcgccaatg acacaaaaaa 3072301 tcctttttat ttttcgatct tggcagattt taattttaat tcaagatata cgcgggaatc 3072361 ctttgaatat ttgtattttg gatttgtcct gccgtactcc tttgatgtat aagagacatc 3072421 ataatgctgt tcaaatgatc taatgagctg ttcaatttct tcttgttttc cagctagcct 3072481 tacctgtgcc acttcgtatc ctccgctttc ataaaaaaac ttactccatg aaatactcta 3072541 acacagtata tcattttttt aacaggaaaa gataacctct actaaggttt tggataagag 3072601 gtgacctcat tggaacaaac agagtttaag gaatatatac acgataattt agcattggtg 3072661 ctgccaaaat taaaagaaaa cgatgatctg gtgaaaaaca aaaaaatgct tgcgaacgga 3072721 ctggtttttt actatctcta tttcagtgaa atgactgatg agaataaggt gtcagaagcc 3072781 attaaaactt tgattaaaga tgaggagacc ttaacgcttg accaggtcaa aaaacgcctt 3072841 gaccagcttg acgcaagacc tgttgaaact gcaaaaaaaa cgattgaatc gattctcaac 3072901 ggcaattgtg ctgtgtttat caacggattg gataaagcct atattctgac cacaggaaag 3072961 aaaaaaacaa gaagcctgac agagccgaca actgaaaaag tggttcgcgg cccaaaagta 3073021 gcgtttgtag aggatattga tacaaatctc gctctgatca gacaaagaac ctctcatccg 3073081 aaattgatca ccaaaaaaat catgatcggc gaaaacaagc tgaagcctgc agccattatg 3073141 tacattgaag gcaaagcaaa aaagtccgtc ataaaagaag tgaaggcgcg gcttaaaaat 3073201 atccagctgg aagatatcca ggacagcgga acgctcgagg agctcattga agataataaa 3073261 tattcaccat ttccgcagat acaaaatacg gaaagacctg acaaagtatc ttcagccctg 3073321 tttaacggcc gtgtggcaat tttggtcgac agttcaccat ttgtgctgct ggtgccggtt 3073381 tctctcggca tcctgatgca atccccggat gactactatg aacgctggat ttcagcatct 3073441 cttatccggt cgctgcgctt tgcttctatc tttatcacct tgtttttgtc atcgatttat 3073501 ataacacttg tttccttcca tcaggggctg ctgccgaccg cactcgccgt cacgatttcg 3073561 gcgaacaggg aaaacgtgcc gttccctccg atatttgaag ccctgctgat ggaagtcacc 3073621 atcgagctgc taagggaagc cggactgcga ctccccaatc cgctcggaca gacgatcggc 3073681 ctcgttgggg gcgtagtcat cggacaggct gctgtagaag cgaatctcgt cagttcgatt 3073741 ttggtcattg tcgtcagtgt cattgccctg gcatccttta ccgttcctca atacggaatg 3073801 ggtctgtctt tccgggtgct gcgttttatt tcgatgtttt ccgccgctat tttagggcta 3073861 tacggcatta ttttatttat gcttgtcgtt tatacgcact taacgagaca aacgagcttt 3073921 gggtctccgt atttttcgcc aaacggattc tttagcctga aaaatacgga tgactccatt 3073981 atccgtctcc caattaaaaa caaaccaaaa gaggtgaata atccaaatga gccaaaaaca 3074041 gactccactg aaacttaata cctttcaagg tatttctatt gttgcaaata caatgcttgg 3074101 ggccggactt ttaacattgc cgcgagcgct gaccactaag gctaatacgc ctgacggctg 3074161 gatcacgctg atattagaag gtttcatttt tattttcttc atttatttaa acacgctcat 3074221 tcagaaaaaa catcaatacc cttcactctt tgaatatttg aaggaagggc ttgggaaatg 3074281 gatcggcagc atcatcggcc ttttgatctg cggctatttc ctcggcgtag ccagcttcga 3074341 gacacgggca atggctgaaa tggtgaagtt tttcctgctg gagagaaccc caattcaagt 3074401 cattatttta acgtttattt gctgcggcat ttatttaatg gttgggggct taagcgatgt 3074461 gtcgcggctg tttccctttt atttaacggt aaccattatt attttgctga ttgtgttcgg 3074521 gatcagtttt aaaatttttg atatcaataa tttgcgtcct gttttaggcg aaggccttgg 3074581 acccattgca aactccctta ccgtcgtttc catctctttt ttaggaatgg aagtgatgct 3074641 gtttcttcct gaacatatga agaaaaagaa atacacgttc agatatgcgt ctctaggatt 3074701 tctgattccg attatcttat atatccttac gtatattatc gttgtcggag ctttgaccgc 3074761 tcccgaggtg aaaacgctga tttggccgac tatttctctc tttcagtcct ttgagcttaa 3074821 aggcatattt attgaacggt ttgaatcctt tttactggtg gtctggatta tccagttttt 3074881 caccacattt gtcatttacg gatactttgc cgctaacggg ctaaagaaga catttggatt 3074941 atcgactaaa acaagcatgg tgattatcgg cataacggtc ttttattttt ctctctggcc 3075001 ggatgacgcc aatcaagtca tgatgtatag cgattatctt ggctatattt ttgtctccct 3075061 gtttctgctt ccgttcattc tctttttcat tgtagctctc aagaggagga ttacaacaaa 3075121 atgaaaatcc ggattttatg tatgtttata tgcaccctat tgctgtccgg atgctgggac 3075181 agtgagaata tcgaggaatt aagcttagtg atcggaatag ggctagacaa gcctgacgat 3075241 gaaaatttag agctgacaca gcaaattctc gtgccgaaaa taatcagcgc caaggagggc 3075301 tcttcatctg atccgacaca gctttctatc acaaagggta aaactgtcca tcaaatgatg 3075361 agaacctctg cattaaagca taagcctacg ttttcacagc atttgcgtct cattctgctt 3075421 tccaaaagcg tgattgcgga tcaaattgga atggacgcca ttattaacca gtttgtcaga 3075481 gacaacggaa caaggaggag ttcctacgtc tttatcacca acggccgaac taaggatata 3075541 tttaacatga atgatgaagg cgaacccgca tccaacgtga tatatgatct gacagagaat 3075601 aataaggtga cgatcagaac gatggagcca gttacattgg gggagatctc agaacactta 3075661 acctctgacg attcattcct catccctcat gtcggtaagg aaaacggcaa gctcgcgata 3075721 aacggagcct ctatcataaa aaataaatta tggcaccggg acctcacccc gattgaggtt 3075781 caaaatatca gcttattttc aggcactgtc gagggaggcg tcattgactt gaagcgcgat 3075841 ggccatctct tttcttatga agtatattca agcaatcgga agatcaagac ggcatacaag 3075901 gacggaaagt tcaaattcac cgttacccgc aatattgaag gtcgtctatc tgaggactgg 3075961 aatcccaatg aagactcgtt taaggattca tatattaaaa gtattgaaaa gacagtcgaa 3076021 aaacgagtac acgaaacagt aacgtcattt attacagaga agctgcagaa agagatcaaa 3076081 gcggacgtaa ccgggctggg aaacgaggtc agaattcatt atcctcaaaa gtggaaaaag 3076141 atttcaagaa aatgggatga tgattatttc agcaatgcgg aaatagacta ccgggtcaat 3076201 gtgattgtca gagacttcgg aacgaaaggc gcaaacaaat agcagccgcc taattcacga 3076261 gatgatttcg gtgtgcgtac accgccgcct gcgtccggtc actgacatcc agctttgata 3076321 aaatattcgt aatatgtgtt ttgactgttt taatcgtaat aaacagttcc tcgcctattt 3076381 ctttgtttgt ctttccttct gcgatcaggc agagtatttc gagctcccgt tttgtaagcg 3076441 attcatgcgg gagcgcgttt tcacctgagt ggcgcagcct ggataatact tttcccgcca 3076501 cttttgactc cagcttcggc tctcccttgc ttgcggcgcg gatggcatcg gcgatttctg 3076561 ccgcttttga ggttttcaac agatagctga gcgcgccagc ttcaataacc gggtacactt 3076621 tgtcatcatc aatgaagcta gtgagcacaa taattttcgg gtcggaaagc tcccggcaaa 3076681 tttgctttgt agcttcaatg ccatccatgc cctccatgac aaggtccatt aaaatgacat 3076741 caggcgacag ttccacagca agccgaacac cttcgctgcc gtccgatgct tcgccgatga 3076801 cttcaatatc gggctgcgcc tccaaaaaag ccgcgagccc cattctgacc atttcatgat 3076861 catcaatcaa taatactcga atcacgttcg ttctctcctt tttcttccgg aaaaatcggg 3076921 accttcactt cgatttgagt gccttttcct tctactgaaa tcacttcggc gacaccgccg 3076981 atttcacttg cacgttcttt catagaattc aagccgtatg aggaggcttt cacctggtcc 3077041 attttaaagc cttttccatt atcaatcacc ttcagacgga gctggctgtt ctttatgccc 3077101 agaatcacgg ttacttttga cgcttttgaa tgtctaaata cgtttgaaag ggcctcctgc 3077161 acgattctga acaagtggtc ttcaacaccc ttggatatcg ctgtgtcctg tatatcccac 3077221 tcaatatcaa tcggctgctt ttttcggaac tcgtccaaaa gctccgtaag gccctccttc 3077281 agcccttttc cttcaagggt aacaggccgt aaatggagca gcagcgccct catctcattt 3077341 tgggcttcgc ctgccatatg ctcgaccatc ctgatccgct tgactgtttt gtcatcagca 3077401 tccttgacat gttccagcac ggctgatgtc atcatcgata tggcaaagag ctgctggctg 3077461 accgcatcat gaagatctct ggccaatcgc tggcgttctt ctgagataac cgacttcttc 3077521 atttgagcct gccattccgc acgttcattg gaaagtttct ggagggatgc gacttgaagc 3077581 tccacgcgct tcgccatttc gttcagctga tcagcagcca ggccgatttc atcatcaccg 3077641 agcggcggta tccgataagc gaaattgccg ttttcaaagg ttaaaatgga ttcaattaat 3077701 gtatcaatcc ttgtcttcaa ccggttgccg tacatatacc ctgaggcgaa accgacggtc 3077761 acgctgatca gaagcaaaat caggataaac ggaattccga accagcttga tgacagcaaa 3077821 acaagcggat cgagccgata gtaaaacatc ataaaggaaa tcaggcaaac aaaaaggagc 3077881 aggctgattc ccgttgtcat gcggatggcg cgccattgga ggctggcaag catttttttt 3077941 ctcatacgta cttcacatcc acatcaccga taaataagga aacggacact tttacccggc 3078001 gctttgactc gctaaaatca gttgacgcgg catatacctt cgtgcttaat ccgcttttct 3078061 tcgagccgat cagattaatg tctcctataa aaacagccga gctgacagcc acttcaaggt 3078121 ccgatggtac ataaatatca acgttaccaa tgactccgct aatgacgatt gtactttctc 3078181 cctcgggaat catcgcttta gataaatcga ttttgatatc accgataaaa ccagagacat 3078241 ttaaatcgtt caggtcaaac ggctgcttca tcatttgcag ctcaccgata aaaaagctgc 3078301 gcatgtcggg atgttttaca tcttttggcg gctcatgatg ttctttttta ttgagattga 3078361 cctgtttctc attcggttca aatatcggct tccctttgat aagcctgtag ccggcgtaaa 3078421 tcagaaatgc ggcaaacgca tagccgaata aattaaaggt gatgctgaag aggtttttca 3078481 aaaatagaaa cgcggcaaag atatacatga cggagccaag ccaatcacgg gaatattttt 3078541 taaggaaata gccggcaatc agaaaaaaga gcggccaaaa cagcagatcg cctattccga 3078601 taatttgcaa aaacatactg atgccgaata aagcaatgat caatccgaga agctgttttt 3078661 ttgtcattcc tggtgtccgc ctcctttctt ctgcctagtg ctaccgtatc gctagatccc 3078721 cgctgtccgt tttgatgtcg attggatgcc ggccgcttcc ttgcgtgcct gtgatgtgat 3078781 gctgttcttt atgtccttta tcagcaaatg aatacggcga actgacgtca ccgcttgctg 3078841 ataaagcatt gactgcaaag ctgccatttt ggggaaggct tacattagca tcaccgcttg 3078901 tcagcgtgac agatacggga ccggttacct ttttcaatac agcattaaaa tctcctgaag 3078961 tcattttcac atcaagagag cctgatacat gaaccagatt tgcgtcccct gaagctaaat 3079021 caatgccggc tgttttggag acggtatttg aaatggaaac atcccccgat gatgccttca 3079081 ctttcagatc ttgaatgcgg acgtccgtca cgctcgtatt tccgctcgca gatactgcgt 3079141 tcagcccgga aagcgcaaga tggtcattcc cggccacaga cacgtcaccg cttgaggttc 3079201 gtactgccag atcaccttta taatcatacg gaagcctgac gataagagtt gaacggttaa 3079261 atccattcaa aaattgaaat tctttttcct ttacggtcag ctccagtttt cttttgtttt 3079321 cagtaacaaa taactttcct gagtctcctg aaatgcctgc cgatatgtca cttcgttctt 3079381 ccgctataat ccggacatcc ttgctatccg actcaatgac catgctgtca atgtcccgcg 3079441 gcgatgcgct ggctgaatca gcttctgtgc catttatgaa acctaggcct gcagcaaaca 3079501 catcttttac gacgacggcg aaaaaaacca gaataccggc agtgatcaac agtttgccaa 3079561 gcattttttt cattcggttt catccttctc attcattcta ttataaagga aaagcttgcg 3079621 aattgatacg tgcggaaggg aaggacttga ccgcaaatcc ttccccgttc cgcttattca 3079681 tttgccgctt ttgtctggtc tgatttttgc agtgaaagtg tccgcatttt ttcaatctcc 3079741 gcttccacat cgtctgcgaa ttctttacgt gtaagttctg tgccggcttc cgctgacttt 3079801 gaataattcg cgcggatttc catttcttca atacgatttt caatacgtaa aaattcacga 3079861 tacgcgcttt cactgtcaat tttgtcaaat gtcgtattca tatgctcttt agctttcgcc 3079921 gcatttgccc gcgcaatcag cgcctgtttt ttatccttta cgtcctgaag ctttgtttca 3079981 agtgcagcca gctgctcttt cagatcagcc agctgactgt ttgcctgttc ataggaagct 3080041 ttatgctcag ccgccttccc ttctaaatac ttcatttcag tcagcgcctt tttcgccagt 3080101 tcttcttcac ctgcgtcaaa tgcgagctgt gcctgatttt tccgtttgcc agccacttca 3080161 gcggcttctt catatttttt cttaaattga taggcaatcg tgtgctgttt cacaattgtt 3080221 tgctttgctt ttgcgatgtc gctttccata tcgcgtacat attgattcag catcaccttt 3080281 ggattctcca ttttatcaag tccttcatga actgacgcaa caaacatgtc tctgattctt 3080341 tttaatacca tacctgattc ctcctaatat attgatatta ttttttcttc aaaaattctt 3080401 cccattcgtc atcaaagtga gattggtagg cagcagaagc cggttcagga tcaaaagatg 3080461 atacaccgtt atcagctgat ccgtttttca tcagcttcca gccgtaatac accatagcgg 3080521 ccgccaatgc gattccgacg acaaacggaa gtgagcagat gagcataatg gctccgatac 3080581 cgcccacgat gattcccgtg atggtttttc ccgcggcaaa ccttttgatt cctgcgtatg 3080641 tcatcaagct cccgatggcg agcgggatga taaagccgaa gcttcctcct ccaaaaaaga 3080701 cggagatccc aaatacaatt aataagaatc cgcctattgt tttcttgttt attttcatgc 3080761 agatcctcct ttcgttttcc ttgtcttcat cttatacaag ttggaagata tgcaaaacga 3080821 atcagagatt gatttttata taagaccgga gtcgtatctc gcaccggacc cattggcaca 3080881 aaaaaacgcc atgcacgagg catggcgttt taaaaccctt tacagatgaa cacttgcttc 3080941 cctttcttta attaggtcgg acctttctgc tttggccaat tttgtaaaca gcaagattcc 3081001 gatacccgca ataatttcga caatcccacc gacagcgatc actttacctg agccgaaagc 3081061 attagcggca tacccgcaaa tgacagctcc ggcagggatc gaaatatttg agatcatatg 3081121 tataacggcg taaacctgcg gctgatcctc actatccaca gacgtctgga taatcgtgta 3081181 ctcaggaaca ttaacagcac tgactgcggc accaaaggta aaagcagcga aaaagacgag 3081241 cggcaaaaag gtattcatcc cggtaataaa gaaagcaaat ccttcaataa tgccggcagt 3081301 gacgaataac aagccgtacc tgtttacctt gactttcgcc agcacaaacc ctaataaaaa 3081361 cgcgcccgcg gcggtggtgg cctttaaaag cgagtatacg atcggctggc cgtttaaatc 3081421 ttccgcaacg tatacggcag agagcgcttc ccatggggca gccgcgaaat tcataaagat 3081481 acagtaaatg gcgagcggat ataaaatctg gtgttttctg acgagcctaa agccgcgttt 3081541 cagtcttccg atatatgtgc ctctctgtgt aacaaccgca gactctgatt gagattcaac 3081601 cgcagtgtac ttaataaaaa gaacgagaaa acctgacacc aaatagagca caagtgcgat 3081661 aagcatggta taagaaggac taataaatgt aagaaaagcg ccgcataatg tgacagcccc 3081721 aagccggaca atttgagcgg aggattgcag cacagcgttt gctttttgaa tgccctgttc 3081781 attgacgatt tgaggaatca aagcgataga ggcgggattg taggcagctc cagtagctga 3081841 atgcacaatc ataagcgtca tgacaaacca cagcggagag aagcccgcaa aatgacatag 3081901 agggataatc aaaacaatcg ccgcccttgt cagatctgaa aagtacatcc aaaatttcag 3081961 cgtggtctgt ttcataaaag gccccgtcac aggcgccaga acggcttccg gcaaaaacgt 3082021 gacagcaatc aataaagcag tgccgatcgc acctttgccg tcataaatta aaaaccataa 3082081 tattgaatta aatgcgaaca tatcgccgga tatcttgact attcttgaga aaaacagata 3082141 attgaaattt ctcttccaga tgctatcact ttcaattaaa ttcaccatcc atcagagccc 3082201 cccgttgcct attttttaca tctatttatt acaatatctc atttttccat ttttcagtca 3082261 ataattcata aggttcattt tttgtcgtaa aatgggaaat tgacagagtg aaaaacaaaa 3082321 aaagccggca tgtatttgaa cacgccggct ttccttttca ctttttatga ttcgctgctg 3082381 tttcggtccc gaaacacaat ggcacttctt tcatattcta catcgccaat accgcttctt 3082441 gcattcacaa cccgggcggc ggcaaagaaa taatcggaca gacgattgag ataacgcagc 3082501 actgtttcat gaatctcctc cgatttcatc agcgccacca ctcttcgttc tgcccgcctt 3082561 gtaatggtgc gtgcgatatg gagaagcgaa gcacactttg atccgcctgg aagaataaat 3082621 ttcttcagtt ccggcgcttc tgctgtatag gcatcaatgc gcgtttctaa aaaggaaaca 3082681 gattcttccg ttagtttata gtcttttctt tctgtgacga ttgccagatc gcctccgcag 3082741 tcaaacagct catgctggat ggtcagcagc tcggctgtca gatcttcaaa gccgggctgc 3082801 ccggaaagct ctgccaaagc aagcccgata aagctgttaa gctcgtcaat cgtgccgtag 3082861 ctttcgacgc gtaggctgtc cttgtccgtt ctgcccccga ctaagcccgt ttgtccctta 3082921 tcgcctgttt ttgtatatag tttcataccc tgaatctcct ttacagactt attcaaacaa 3082981 ctcagcagcc tcttttatac attcagctgt ccctttcttt atcaattggt tcagccgctg 3083041 ttctatgttt tctgattgct gagtttgagt cgcggcgatg agaatatcac ctgtgcctcc 3083101 tccgtctccc agcactttcg tccgttctgc ttcggcagcc ataagagctt tgatgaagaa 3083161 ttgatctgcc gcatagccgt taatcaaaat ccaaatcgaa aagccggtct gaacgcatat 3083221 gaaaacggat aactctccgt cttcatatgt tcgatacacg aaacggtcaa gtctttctga 3083281 agaagccatc gcacacgtct cctgcagttg aaaaccgctt tctgaaagac aggccgtaag 3083341 tccttctatc ggatctggct gatctggcag ccgtttatgg atcagcgtcc tgctccacga 3083401 aaaccctgca ccgataggcg tggaggacaa tgttcgaagc gggatttccg tttgcagaag 3083461 aatgtcatca cgccccgctt ggagcaatgc ttcaaatggg atagactgcc gcttcacgct 3083521 atctttttca ggctgaatca caatcatcgg tttaggtgag ctttgatgaa ccaaggcggt 3083581 gacatctgta tcgtacaccg cctttatgct ttgttctgta acagcatatt ccggtttttg 3083641 cttaggcccg gcggtaccgt ttttcataaa catgagccca tcacagtaca ggcttgcggt 3083701 gttcagatca tgaaaaacgc tgacagctgc caatccgctt tctctcgtca ggcgtttgat 3083761 cagatcaagc aggtcttttt gataagccag atcgagaaaa ttagtcggct cgtccaaaaa 3083821 taaaatacgc ggctgctgcg ccaaagcttg tgccaaatac acccgctgct gttcccctcc 3083881 gcttagttcg cgaatcggct tttgcgcaaa atcggccact cctgtttgct ccattgcttc 3083941 ctgtacaatg gcttcaccct tttcagtctg ctgtctgaac agccccgttt ggaatggata 3084001 tctgccaaag gctacagttt cttcgacagt aaaggtgaag gcttgatcca ttttttgcgg 3084061 caggacagcc atgatttgcg ccagttcctt cggtttatag tccgccagca gttttccggc 3084121 cagataaacc ctgcctttct tggccggcag cgtacctgtc agcaagtgca aaagcgtggt 3084181 ttttccgctt ccattagggc cgagaattcc aagaaattct cccttctcca ctgttaagct 3084241 gacattgttg attaggcggc tgtcgccgta tcctcccgac agcccttctg ccttcatcat 3084301 aagcttctcc ccccgcgatg ctgccgaatt aaaataagag cgaacacagg cgctcccgcc 3084361 aaggacgtaa tgatcccgat cggcagttca atcggctcaa tgatggttct ggaaagcaga 3084421 tcggctaaaa caagaaaccc tgccccaagc aaggcggaca acggcagtaa atgccgatgg 3084481 tccgttcccc acaaaagcct tgtgatatgc ggaatcacaa ggccgacaaa gccaatcgta 3084541 cccgatactg ccacagcgct tcccgtcaaa agagatccgg ctattaaaat catcatcttc 3084601 ctctgctgaa cgctgactcc aagaagcttt gctttatctt ctccatatgt catcacgttc 3084661 agttcccttc cgtttataat caataaaatg gttcccaaaa gaaaaaacgg gagaaacaaa 3084721 ataacatagc tccagcccct cattgagacg ctgccaagca gccaatgcac aatcggaagc 3084781 aggttgtctc ctgtcaaggc gatgataaga gaaataaatg cgcctaaaaa agagttggtg 3084841 atgacaccgg tcaaaatgag ggtggaaaca gacatcgaag catgaacgag gcggctgaag 3084901 aaaaggaccg ccgccatcgt ggccagtgcc gcggctacac tcaaaaccgg gagtgtaaac 3084961 cctccgatga caggaaggtg caaacctaag aacagagtca caacagctcc gactgaagca 3085021 ccggatgaca cacctagcgt atagggatca gcaagcggat ttttcaacaa tccttgaaaa 3085081 gcggcccctg caatagaaag agccgccccc acaagggcgg ccagcacaac tctcggcagt 3085141 ctgatattca tcataatatt agtgtacatc ggatcatcag aaccgataga gccgccgaaa 3085201 ccttgatgcc aaaagacacg aaaaacagcg ggaataggaa tatgcaggct gccgcaagaa 3085261 attcctaaga tgatgctcac ggctaaaaat gagaaaccaa tgatatatgc ggcataacga 3085321 ttattcctta aacgtatccg ggtaaatgct ttccgcaagt tcttcgaccc cttcgatcag 3085381 acggggaccg gaacgtgtca caagatcagg gtccacatca tatacacgat gatgtttcac 3085441 agcattgatt tcgctccagc catcgcgttt ttccacagct ttcgctttca caccgtccgt 3085501 tgtaacaatt gcatcaggat tgagttttac gatcgcctcg tctgtcattt gcacccatcc 3085561 tgtctgatcc gcagctgcgt ttttagcatg gatgacattt agcatttcat tcataaacgt 3085621 atcttttccg gttgtataaa tgtcaggatc aggagaaacc tcgataaata cgcttttctc 3085681 ctcgtctttt gaaatggttt tcgctttttc ttgaatatcc tttagatctg atttcatgct 3085741 tttcacgagc tgatcggctt ttttctccgc cccgccagct tctccgatca tttcgattga 3085801 tttgtacacc tcggagaatg attgtgcatc attgacagtc agcactgtaa tgcccgcgtc 3085861 cttcagctgt ttgatggcat ccgctgatgc tgacatggaa gactcatggg ccagaacgag 3085921 atctggtttt agagaaatga ctttttcaac gtttacattc atatctccga ctttctcaac 3085981 ctttttgact tcctttggat aggtatcgtt tgtggtgaca ccgaccactt tgtcaccaag 3086041 gccgagtgcg tatgtaattt ctgtgttgct cggcattaat gaaacaatct tttttggctc 3086101 ttttttgatg gttacatctt ggtttgacgc atcatcaatg gtgacaggga acacttctgt 3086161 tttttgtttt gcctttgaat ccttctgatc cgcaggattg ccgcagcctg ccagcataac 3086221 agcagccaac agaagcgcag cccatatccc ggctcgtttt ttcataatct tttcctccta 3086281 aacgaactaa aaaagcatct ctacgacggt aaagatgctg taaacaacac aaaaaagcct 3086341 attgtttaca catcatctgt cctcgcagaa ttcgtgctga tcaaacaggc aggtatcctg 3086401 gctcttggcg cttggccaat tacagtggcg ggaccgcacc ggcttttacc ggtttccctt 3086461 ttaagccggc tgttgttcac ggaccggcac ctatttgaca ttcgtatccg tttttcggag 3086521 taattatact atatgactga caggcttgta tatgtgtcct gaatgacttt tccccatatt 3086581 gtgtatggaa gcaaaatcct cgtaaacact aaatttgatc ttgtatactt aataccatca 3086641 tctatcaaaa ggaatgattc ttatggattt acagctaaaa gaaaaactcg tcttaatcac 3086701 cggctcgacg tccggtatcg ggaaagccgc cgcaaaaagc tttctgcaag agggtgcggc 3086761 agtcattgtc aacggacgca aacaggagac tgtcgatcgc accattgaag agctttctgg 3086821 ctatggaaca gtgcacggtg ctgctgccga tttgtcaaaa acagatgaag cagcggcttt 3086881 tatcgaaaaa gtaaatgaaa tcggtgatat cgatatcctt gtcaacaacc ttggtttctt 3086941 cgaggtaaaa gacttcgccg atgtgacaga tgaagagtgg aatcaatatt tcgaagtgaa 3087001 cgtgatgagc gccgttcgga caagccgtca cttccttcca aaaatgcttg ccaaaaacag 3087061 cggccgcatt ttaaatattg caagtgaagc aggcgtcaaa ccgctgccaa cgatgattcc 3087121 atactcaatg acaaaaacgg cactgatcag cctttcaaga ggaatggctg aaatgacaaa 3087181 aggcacaaat gtgacggtca actcagtgct cccgggacct acttggacag agggcgtggc 3087241 ctcctatatg gaaggcgccg cacaagcagc cggacaggat acagatacat ttatcaaaga 3087301 ctatttcaag gtcaatgagc caacctcact tattcagcga tacgcgacag cagaagaagt 3087361 cgccaacaca atcgtattcc tcgcgtctga cgccgcatcc gccattaacg gcacggcaca 3087421 gcgtgtggaa ggcggcatta tccgttctct gtagtataaa aaaacgcatc cgtgtttcgg 3087481 atgcgttttt tttatacgtc tccagcaaat ggtaccggct gatatccgcc tgtttccagt 3087541 tgtgctgaaa acaaccctcc agcgtgaggc tgctcgtatc tctctttttc tgtcatttgt 3087601 tctgttgccg ttgtaatgta aagggttttt aagtctctgc cgccgaacgc gcagcacgtg 3087661 acatatttag ccggcacgct gattgaattg atttcttttt tctgaaacgg gtcaatgtga 3087721 acaacgcggc tgccgccaaa cagcgccacc cacagcatgc cattttggtc aattgtcatg 3087781 ccgtccggca atccgtctga ctgatcaaaa cgatagacag gttctggatt cgaaacatct 3087841 ccgctttgag gatcatagct gtaacgtaca atctcctggg tcggcgtgtc gatgtaatac 3087901 atcaaattcc gctcgcggtc ccaatccaaa ccgtttgagg tggagacttg atccttgatt 3087961 ttgacaagac tgccgtctag attcaaacgg tacagcgacg cctgtttttg ctcgccttcc 3088021 atgctcgtcg tccccgccca aagccttccg tacgggtcac atttagcatc attaaatctc 3088081 aggctctcat gcatgtcctt cggctgttta attttttcca agctgtcatc ccgaagatga 3088141 tacaggtaaa acccgtcctt catcgtcata atcagttcat cctttgaata tttcgcaagc 3088201 gccgtcacaa aggatttgaa tttgattgat cggttgattt tttcttcagg gtcaaagatg 3088261 tggagctcgc tccccaggat atcaacccaa tataagcggc cgttctcttc atcccataac 3088321 gggccttcac caatcactgc ccgagtgtct gcttccaata ctgcatccat gtgttacacc 3088381 tctttagctt cagtctatat attgttattc ccggcaaaga ggtgtccaaa ccacttgatg 3088441 tttattgttt tttaaaaagg atggtaatga ccgttccaat gttcgttctg ctgttcacat 3088501 ggatcgttcc gttatgcaga tggacaagct ccttggcaat cgcgagcccg agacccgttc 3088561 cggcagttga atcttttgtg ttcgtccctc tgtagtagcg gttaaacaaa tgggtgatcg 3088621 tttcttcatc cattcctttc ccattgtcct tcacttttaa agaaatatga ttttttgttt 3088681 gctccagaat gacttgaatc tctgttcctt tgccgttgtg cttcacggca ttcccaagga 3088741 ggttttctaa tatgcgcctg aaccacgctt catcaagggc aaattcaata tgctcttctt 3088801 tggatacaaa cgagatatca tagccttcag aaaacggatt tttcttaaaa tcctcaatga 3088861 catttttaaa aaacgggata aggctagtga gctttctctc aataggaaga gcatcatttt 3088921 tcaggcgata cgttaaattt aagtcttcaa tcagcttaga catgtattca gatttttctc 3088981 tgacaacctg ccccatttct ttcacttctt ccggcgacca gtcatactgc ttcgactcga 3089041 gcatcatgct gtagccgtaa atgctgctga gcggtgtttt taagtcatgt gacaaaccgg 3089101 caatccattc ttcccttgtc gcctggattt tttctctgtt tcttttatcc cttctcagcg 3089161 tttcagtcag ctgatccatt gattcaaata tctcaccgaa gaagcggtac ggctgtttga 3089221 tttttccctt tttatttttg ctgacaggac ggccttcccg gtttctgggc tcctcaagct 3089281 tcccttttga cagattgacc agccatctaa tcgtgtgaaa aatcggcagc ccgaatcgga 3089341 acatatacca aacggtcatc caaatgatat acatgaacaa aacggccatc acgagaaaca 3089401 tcgcttttaa tacaaccttc aggaatgatt tgttaaactc ctgatcggtt acatagactg 3089461 ggttcggcac cgtagcgacc atccatctgt ctttattgag gatcttaacg gaaatttccc 3089521 gcttatagtt ccaaggctta gagctgtatt taagcagctc cagctggttc atcgtttttc 3089581 tctcgctttt tgtgctgttg atgctgtcga gaatctttcc attgctgtct aacaggtaaa 3089641 tggcgccttt tttccgttta atatagtcga tggtactaga cttatagtgc gctagtgagt 3089701 ctatcttttg ttcacgcttt tcaacggaag tcaggagctg ttcacttttt gatttccagc 3089761 cggacaatag aagatacgac ttatcttcaa tattgatggc ccaataattc agtttatagt 3089821 tatgaagctt tttggtttta taaatagaca aaagctcttt cttggtatag gtgcccggca 3089881 cgtcttttgg cacgccgtag gaataatcag tgtttccttc cgaatcaatg atttgcatcc 3089941 agccgtgctg tttatcaaca gatttcttca ggaaattatc cacttcccat gtcccgtctt 3090001 cgtttacatc gagatatgcc tcaagtgtgt cggtcgttgc tttcgtcagc cctgaattgg 3090061 attccgcatc gctaaaacgg gcgtctaaat agaaaaacga tgcaacaagc ataaccgtaa 3090121 gcagcaggat cacaatcagc atctggccga aaaagtgaaa caaaaacttc catcttaacc 3090181 tcatgaccgc ttgccttcag gatttgggat aaaacgatag ccgagacctc gaacggttac 3090241 aatatactcc ggattgctcg gatcgcgctc aatcttctcc ctaagcttgc gaatatgaac 3090301 catgacggtg ttgttgtcac cgtaggaagg atagccccat actttttcat atatttgatc 3090361 tttggaaagc accacgttag ggtgttcaca aaaatactgc aaaagctgca gaagctgggc 3090421 tgaacaggca acggcttccc cgcctacgat caactcggca ttttgcggag aaaaagtaaa 3090481 gtaatcatat gtgtaggttt gatttgaact cgtttctttc gattgatatg tacgcttgag 3090541 atgcgctctg atccgcgccg ctaattccag cggattaaat ggttttgtga tatagtcatc 3090601 agctccaacc gcaaagcccg ataatttgtc cgcgtcggat gatcttgccg tcaggaaaaa 3090661 aatcggagcg tctgaatact ctctgatcaa tgtgcaggct tcaaaaccgg acattccgcc 3090721 catcatgaca tccagcacaa tcaagtcaac cttattggcc ttcacaacgg gaatcgcttc 3090781 ttctgcgctt gccgcatcca gtatatttcg ataaccttct ttttcgagaa cgcgtttgat 3090841 catgtccaca atcgctttct catcgtctac gattaaaatt gacgcatttt ccacttttat 3090901 gttcctttct gtcactgttt ttttcatctt atcattatat cgtttattta tggtacattt 3090961 ttgaatacat tggagccttg gcaaatcaaa acagcaaaaa aggagcaaac aagcgctccc 3091021 ttttgatgtt ttttcatatg aaaatattat gagttctcat ctaccatgta caaaataaac 3091081 tcccaaaacc ccggtacatc ctgacataaa agcatatcag ccttttcaaa cattttgatc 3091141 ttcagctctt gctctaaatc ttctctttct tgataggacg tattgctgag tttttttctg 3091201 atcatcggtg aaaagcatgc aatcaggtgc tcaatgtcat aagtctcgtc tttttgtttc 3091261 tttttttgtt caaactggcc gtccacagct tacttttccc cctttttttg cgccgctaac 3091321 tgctttctga tattctccag ccccttttta tgaatgttgg agatgttttg tcgggactcc 3091381 cctaatgaat ctgcaatctc ctgcatcgtg gcaccgtgaa gatagacttt cgtcagcaca 3091441 cttttttgtt tgtcagtcag cttctggatc gcttggtaga gctggtaatc ctgtacatgc 3091501 tggctcaaat catcctgcct gtctaaaaat tcttcaaatg catcgctacc tgtttcggaa 3091561 gaaagccgat ctcccgcctc cggatgatca accgtcagtg gataccgttt ttggtttttg 3091621 cgaacccgct tatcaaaatc aatagaaaag atgcgaatca ttgaattcat atacttgacg 3091681 atgcggattt ctttataaaa ttgcttaaat agctcgtcca atgatcttgc atctttttcg 3091741 ttagggcttt ccattacgtt tttgaacaaa cggtaatgct gaggattgct caaaaaatgc 3091801 ttcacgatgg gatgcttcat tatctcctta cattttgacc gtaaaagact ttgatagtcc 3091861 atcaaaccgc ctccctacta aattaaatga aggaaagcaa aaaaaagtaa actactactt 3091921 tccgcctagt gtcttccaaa atactttgca gcagtttacg ttttatcggt tttcctcact 3091981 tacatacatg actgcagaaa aagaagggag gtattttcct atggatcagg tttttataga 3092041 ggaagtcgta aaacagatcg gcaatttggg gtttcccgcg ctgattgcaa tgtatctgct 3092101 gacccgattc gaaaagaagt ttgatcaact aatagaacta atgacagaac tgaaagatca 3092161 tgcaaaaaaa taatttttca atcgaagttg acttttcact ggtttttttc acttaacaaa 3092221 acagaaggga aaacgaaagg cctttcacct tctctttctg ctatcacatt taaatgtaag 3092281 gaggaaacat ttcatgaaaa aacaaaatga cattccgcag ccaattagag gagacaaagg 3092341 agcaacggta aaaatcccgc gcaatattga aagagaccgg caaaaccctg atatgctcgt 3092401 tccgcctgaa accgatcatg gcaccgtcag caatatgaag ttttcattct ctgatactca 3092461 taaccgatta gaaaaaggcg gatatgcccg ggaagtgaca gtacgtgaat tgccgatttc 3092521 agaaaacctt gcatccgtaa atatgcggct gaagccaggc gcgattcgcg agcttcactg 3092581 gcataaagaa gctgaatggg cttatatgat ttacggaagt gcaagagtca caattgtaga 3092641 tgaaaaaggg cgcagcttta ttgacgatgt aggtgaagga gacctttggt acttcccgtc 3092701 aggcctgccg cactccatcc aagcgctgga ggagggagct gagttcctgc tcgtgtttga 3092761 cgatggatca ttctctgaaa acagcacgtt ccagctgaca gattggctgg cccacactcc 3092821 aaaagaagtc attgctgcga acttcggcgt gacaaaagaa gagatttcca atttgcctgg 3092881 caaagaaaaa tatatatttg aaaaccaact tcctggcagt ttaaaagatg atattgtgga 3092941 agggccgaat ggcgaagtgc cttatccatt tacttaccgc cttcttgaac aagagccgat 3093001 cgaatctgag ggaggaaaag tatacattgc agattcgaca aacttcaaag tgtctaaaac 3093061 catcgcatca gcgctcgtaa cagtagaacc cggcgccatg agagaactgc actggcaccc 3093121 gaatacccac gaatggcaat actacatctc cggtaaagct agaatgaccg tttttgcatc 3093181 tgacggccat gccagaacgt ttaattacca agccggtgat gtcggatatg taccatttgc 3093241 aatgggtcat tacgttgaaa acatcgggga tgaaccgctt gtctttttag aaatcttcaa 3093301 agacgaccat tatgctgatg tatctttaaa ccaatggctt gccatgcttc ctgaaacatt 3093361 tgttcaagcg caccttgact tgggcaaaga ctttactgat gtgctttcaa aagaaaagca 3093421 cccagtagtg aaaaagaaat gcagtaaata aaagacttgc ggcttgcaga gagcactcgt 3093481 tctctgcaag ccttcataag gagctgaacc agtgaaacat caaaaccctt caaaacgctt 3093541 attgcggctc tccataaagt acttgctggc cgcagcagca gtggtgttga cctattttgc 3093601 tgtcatctat atattgtttt ctttagcggg aacgagctac cgctcagcag ctcatgtcct 3093661 gctttttgcc gtggtattcc ttgttctcgg attatgcttt gaaccatttg aacggctgat 3093721 gatacatagc tttacatttt tcaagacagg aaaacgtcta ttcattctcc ttgctggcat 3093781 cgtacagctg ctgtttttgt ggatgactgc tcatacaaca gaccaattga tcagcgacat 3093841 ctggctgtcc accacagaag aaatgattgt cgcagccgtt tttttgattt tagacaaatg 3093901 caactcggct cttcccagct aaaaaaagaa cgcattccaa ttggatgcgt tctttttatt 3093961 catagcgaag cgcgtctaca ggctgaagct tcgaagcctt gatagacgga agcaagccga 3094021 agataatgcc gactgccatt gaaaagatga gtgctccgac aacagctgga atggagacga 3094081 taaaaggcat cggaaaaatg accgtcagca gcttggcgat gccgaagccc gccagcacac 3094141 cgagtattcc gccaatgctt gtcagcacga cagcctcggt taaaaattga aataaaatca 3094201 cacgccgctt agcaccgagc gctttcttaa ttccgatttc cctcgtgcgc tccgttacgg 3094261 aaacgagcat aatgttcatg acgccgatac cgcccaccaa aagtgaaata ctggcgatac 3094321 cgccaagcag caatgcaaat gactgattaa aggactccac ttcctgcgcg atctcctgaa 3094381 gatccattac actgtactct gctttttcca gctcagcttc tgacagtccc tgatttaaaa 3094441 gatctgcagc cattacaccc gcttcttgga tatgctcaga agaatcagcc tgcacggcaa 3094501 tctgcgttgg cgcgtcaaat ccttcaataa gcggccacac ttttttcggc acgtacaaaa 3094561 ccgggttcgc atagtcgcct tcaaacatgc tttcctgttg atttttttct ttaaaaacac 3094621 ccacgacctt aaacggcaca ccattcatct caatgctttt atgcagagct tctccgtctg 3094681 gaaacagttc atctctgaca gcttcattga tcatcactac ttggtgtgtg ctgtttaaat 3094741 cgttttccgt cagctttctc ccttcggtta ttcggattgg aaacatgtcg aagtaatcat 3094801 cgtccactcc atacacttgg ggatacgaaa cgttagttaa atgaaaaacg ctcgcgcctt 3094861 ctgacaagta atataaggat aatcctttga ccatcggatc tgatttgatc gcctttactg 3094921 tttcttccgc tacaggcggc gcggacgcat acgacacctg agggccgccg ctctcctctt 3094981 ctccgccaga cggctggtag acaacattga tggcgttgtt tcccatgccg atcatacttt 3095041 gctttaactg ctcactttgg cccttcagca ttgaaacaat cgcgatgatt gccgctatgc 3095101 cgataatgac gccaagcatt gtcagaatcg atcttaattt atgagagaaa atggattgaa 3095161 aggagattcg aatatgttca agcatggctg atatcccctc tctcatctaa taccaactct 3095221 ccgtctctga taaaaacggt tctgtcagct tttttggcga cgtccgggtc gtgggttatc 3095281 ataataatgg tcttgccttc ccgatgcagt tcagaaaaca gtgccaaaat ttgttcactt 3095341 gatttggtat caagcgcccc ggtcggttca tcagctaaaa taaacctcgg ctgattgaca 3095401 agggccctcg ctatcgccac ccgctgcttt tggccgccgg acagcttagg cggtttgtag 3095461 gagaccctgt cttttaatcc gactttttcc agcgcttcat atgcccgttg ccttctctct 3095521 tttttcttca ctttattgta gatcatcggc agctcgacat tttgcagcgc ggtgagacgc 3095581 ggcagcaaat gaaaagtttg aaacacaaac ccgattgatt cattgcgaat ttcggctaaa 3095641 gccccgtctt tccctttcaa tatatcgatc tggtcaagcg tataggttcc tgaggttggc 3095701 ctgtccaaac agccgataat attcattaac gttgactttc cagaaccgga aggccccata 3095761 atagctaaaa actcccccgc ctgaacggtc agattgatat gtttcaagat tggaacttct 3095821 tcttttccca gcttgtacga cttcgaaata ttattcagtg tcagcattga ctgtaacctg 3095881 ctttccttcc ttgaccgcgg gatcaggata gatcacataa tcttccggcg tcaggccgct 3095941 cttaatttcc accatgtcat tttcatcagt ctctccgatt tcaacaggct gcttaaccgc 3096001 tttgtgattc tcatcagctt tccatacgta cggttcgccg tcatcctgaa tgaccatgtc 3096061 ggacggcagc ttgatcgtgt ccgcatcagc attatcactc atcacttcga tgttgacatg 3096121 atagccgact tcaagacctt tatggctgtc taataaaatg gtgaaaggat agttagagga 3096181 ctggggattc atttcttcat cagcaaagct ttctgattct tcaccctcgc ctgctcccgc 3096241 tggaagcttg ccgatcgagg tgacctttcc tttccactcg ccctcaccgc ctgttttcag 3096301 cgtgaccctg actttgctgc cttttttgat cgtgtccatt aacagctcat tgatttggct 3096361 tttgaccaga tatttgcctg tcgaaacaat ctggatatac gggcctgctg cctggtcgcc 3096421 tgttgcaccg tcagcgatat cctgattgac gctttgaacg attccgtcat gcttgcttgt 3096481 aatgacattg gaacctttgt ttttcgtcag gccagccagt tctttttgat gctgcttcag 3096541 ttcaagctgg cttgttttca aatcgaaatt ggtttgatca agttcatctt gaagctggtt 3096601 tttctcttct tttcctgcaa ctttcagctt tttttccgtt tccgttattg atttttgcaa 3096661 acggttgatt tgcagatttg tcatttcaat ttgcaaattg gcttgctcca cttcatcaga 3096721 atgatcctcg ccctcatact caaaaagctt atcgcccttt ttaacctgat cgccttcttt 3096781 gacgtatgtt tttttaatgc tgcctttttc tgaatctatg tatactttct gctgtttctc 3096841 aggttcaacc tttccagaaa acgtttggcc tgattctgaa tctcctccca tgtataccgc 3096901 gaccgattca gcatagggct ccgatgatac ggcaacttgg ttcatgtgag taaaaaagta 3096961 aaaaccgcca gcgccgatcc cagccaatac aagcacaccg gcacatatcg caccgccaat 3097021 aagccatttt ttcttcttgg acacaacgat ctcctctttc tgtaaactat gtaatatttt 3097081 cgaaacattc taaccaatat tatctattaa ttcaaaaaga cttgcaatcc ttttattgaa 3097141 atgacggaat caaatagaaa aattgtattt tcaaagccga ataaaaaaaa tcccggcttc 3097201 aaaccgggat tttttcatac agtaactagc tctttttcat ttttaatcaa gtcatatgtc 3097261 aagcatacag gtttatttgt acggggatca gtcacgattt cggcatcaat ctgaaatacc 3097321 tgcttcaaaa tgtctggtgt catgacctcc agagcagttc cttccttgat gaccgtgcct 3097381 tttttgagcg cgatcatata atgagaaaaa cgagctgcat ggttaagatc atgaatgacc 3097441 attaaaatcg tccgcccttg ctctttgttg agtctgtcaa gcagctgcag aatttcaagc 3097501 tgatgtgcaa gatcaagata cgttgtaggt tcatccagca gaagcagttc cgtcccttgc 3097561 gcaagcgcca tggcaatcca cacacgttga cgctgtccgc ctgacaatgc ctcaatcggc 3097621 cgttcagcat attcagccat gcctgtttct tcaagcgccc atttgataat ccggcggtct 3097681 tcgtcattta atctgccgaa tcctgattga tgcggaaacc tgccgtacga caccaattcg 3097741 tgcactgtta ggccgctcgg cgcttcaggt gtctgtggaa gaatcgccat atcttttgca 3097801 atgtcctttg tagacatttt atgaatcgct ttgccgttta aatagacggc acctgcatgt 3097861 gaacgcataa ttctggacat tgtttttaaa atcgttgatt tcccgcagcc gttcgggcca 3097921 attaaggtgg taattttccc tttaggaatc gatatattta aatcctctac aatcaccctg 3097981 tcgccataac cgattccaag ctgttccgtt gataatgaat tcatattcgg ccccctcctc 3098041 taattcgctt tcatcaataa ataaataaag taaggcgcac ctagcacgga aatgacaagt 3098101 ccgaccggaa tttctgatgg tgccaataca tttctcgcca gcgtatcagc aagcaaaaac 3098161 aggaatgagc cgatgaaggc ggagaccggt atcagcgtct ggtgacgtgg accggtcagc 3098221 cttctagcca catgcggcgc gatcaatccg agaaacgcaa tgccccccgc agctgccacg 3098281 catgaagcgg caagagtgac cgctgccaga agaagaatcc gtctttcctt ttcaacagcg 3098341 gtgcccagcc cggtcgccaa ttggtctccg agctgcataa tgttcaaata gcgtgcctta 3098401 tataaagtaa acagaagcaa gatcacaatc caagggagaa tcgcccagat catattccag 3098461 ttcgcccccc atattgagcc ggatatccaa accgcggctt gcataaaatc atgagggtcc 3098521 atcttgagct gaaaaatcag caacagggcg ttgaatccgg cattcacccc tatgccgact 3098581 aaaatcagcc gaatcggtgt cacgcctttt ttccatgcca gaatataaat gagaaacgca 3098641 gcgaggattg ctcctgccaa agcactgaac ggcagcataa atgttccgaa aaagctaaga 3098701 tctgaagctg acccttgaaa aaagtatata aaaagcacta cagcaagtga accgccggcg 3098761 ttaattccga gaataccagg ctcggcaagt tcattttgag acacgctttg caaaatggct 3098821 ccagctacgg agatccctgc tccaacaagc aaagaaagga tgatccgggg cagcctgaac 3098881 tcaaataaga caagttcatc acgcgccgtt ccttggccga aaaagacctg aagcgtttta 3098941 agcggtgcaa ttttgataac gcccaaattg agactgataa aaaagaccac cacgataagc 3099001 aaaaaggtca cagccattac aatgagcggt ttgtttgttt ttgttttcat tacagccctc 3099061 tcctttcacg acgtgccaaa taaaagaaaa agggaacgcc gataagagaa gtcagcgcgc 3099121 cgacaggcgt ttcaaagggc gcatttacga gtctggccgc tatgtcagca aaaacaagca 3099181 aaacagcacc gagcaccgcc gagcaaggaa tgatccaccg ataatccaca ccgaccaaaa 3099241 aacgggtaat atgcggaatg atcagcccga taaatgcaat ggtgccggca atggaaaccg 3099301 cagctccggt cagaattact acaataagca tgccaaccag tttcaccgct gatgtatatt 3099361 gtccaagccc ttttgccaga tcgtcaccga gacttaacac tgtaacagac cgggcgatga 3099421 aaaacgcgag cgttaaaccg acagcccctg caataagcaa aagctggacc cccgaccatt 3099481 tcacacccgc taccccgcct gcgtaccaaa agctgatatc ctgagcgaca tcaaagcgga 3099541 ttgcaatggc agttgaaatg ccggtaaaga aataagtaac tgccgtaccc gccagagcaa 3099601 gctttacagg cgtaagtccg ccccttgaaa acatgcctat gcccattacc gtcgatgccc 3099661 ccagccccgc tcccgcaaag gaccatagca caagccccat tgcagaaagt ccgggaaaaa 3099721 aggcaaacgc aatcgaaacc gcaaacgcag agcctgatgt cacacccata atcgaaggct 3099781 ctgccaaagg gtttctcgtc atcccctgca tgattgctcc cgacactgcc aacaatgcgc 3099841 ctacaagcgc ggcagccgcc gttctcggaa gccgaagatc atgtataatt tggtgagatg 3099901 tctttgtcgg ctgataatga aaaatggcct cccatacagt gcgcaaatga atatccgctg 3099961 cacctaggga tatggataaa aatgcgccaa ggcaaagcag gcatagacct gcgataagga 3100021 cgatgaccgc gccatatgtc cttgacgtcc attggatttc ttctgatgca gtccgtatat 3100081 ttttatgttg actcaactgc cgtacttcct ttctgttact gataatgatt atcaattgct 3100141 gtttcagtat atcacttttt tcagctgatt taatagagtg ttttgaacaa aaatgaaaat 3100201 gcatttgcaa aaatatcgtg tcaaccggca cttgcagtgg tataatcaca gatgataatg 3100261 attctctttt tcatctatct tttagaaaga aggtatgaga tatgacccat atatacaaga 3100321 aactcggagc cgcgtttttt gccctgttat tgattgcagc gctggcagcc tgcgggaata 3100381 actcagaaag caaaggttct gcctctgatt caaaaggcgc agaaaccttt acatacaagg 3100441 ctgaaaacgg aaatgtaaaa atcccgaagc atcctaaacg ggtggttgtc atggcagacg 3100501 gctattacgg ctacttcaaa acactcggca tcaacgttgt aggtgcgcct gagaatgtat 3100561 ttaaaaaccc ttactacaaa ggaaaaacca acggcgtcga aaacatcgga gacggcactt 3100621 cggttgaaaa ggtcattgat ttgaaccctg acctgattat cgtctggaca acacagggcg 3100681 ctgatattaa aaagcttgaa aaaattgcgc cgactgtcgc agtaaaatac gataagctcg 3100741 acaacatcga acagctgaaa gaatttgcaa aaatgacggg aactgaagat aaagctgaaa 3100801 aatggctggc caagtgggat aaaaaagttg cggccgctaa aacaaaaatc aaaaaagcgg 3100861 tcggtgacaa aaccatttcc attatgcaaa cgaacggaaa agacatttac gtatttggta 3100921 aagactttgg aagaggcgga agcatcattt acaaagacct cggcctgcag gctacaaagc 3100981 tgacaaaaga aaaagccatt gaccaggggc caggttatac aagtatttca ttagagaagc 3101041 tccctgactt cgccggagat tacattttcg cgggcccatg gcaatcaggc ggtgatgatg 3101101 gcggcgtttt tgaaagctcc atttggaaga acctgaatgc cgttaaaaat ggccatgtat 3101161 acaagatgga tccgatcgga ttctatttca cagacccgat ttcattagaa ggacaactgg 3101221 agtttattac ggaaagcttg actaaataaa caaaagagcc gcctgcccgc ggctcttttg 3101281 cttatttata aggaacggct caatttgaat catatcggat attttctttg agccattcat 3101341 attaagctgc atcctcatca cgatcagttt ttttatgctg gagagactga aaaacgtttt 3101401 ttgcatattt aacgaacgga ttcctaacag gagaaattgt gattttataa aaaagacacc 3101461 tgagcaaatc aggtgtcttt tcattatgct tgtttttctt tctggaactt gttactcaca 3101521 aatggataaa cgattaagcc gacaaagaat aaaccgatgc cgagtataaa tgtcgttaaa 3101581 tctgctgtgc ctgttacgat aacaaacacg gagtatgcac acgccagtat cgcgatcaat 3101641 ccgtctctta cacgggagcc tttcagctgg tcatacgttt cacctttgat gactaccttc 3101701 aagctgtaga ttgcagatac cagatacgga attaaatatg cgagtgtagc cgctgtcgtt 3101761 aaaaatgtaa atgcgtcact tattgtccgg gaaataaccg agaaaatgaa gacctgtgac 3101821 atgacgtttg taataatgag tgcaatgacc ggacttccct ttttattcgt ttttgcaaaa 3101881 aatgccggga aatctcctgc tttagcggct tggtatggca cctcagagcc aagcaaaatc 3101941 cagccgagca tcgttccgaa taaacaaagg atagccaaaa gcgccataat cacgcttccc 3102001 gcgtttccaa caatcgcata gagtacatca acaaatggtt tttcagagcc gacaagctta 3102061 tcatgcggca gaacacccat cgtaattaaa gtcacaataa tatatatgct caaggcaatc 3102121 agcaagccgg taattgtcgc acgtttcaca tcacgctgag agcgcgcacg gccggacagg 3102181 atcaccgcgg attcaattcc gacaaacgcc cacagtgtag aaatcgcagc gttatgaacc 3102241 tggccaccaa ttccaatgct tgtgccgttt tctccttgaa ccgggaaata aaaatgaccg 3102301 aataatgacg tttgaaacac aaacaaaccg gcaacgataa agaagacaaa acctaatact 3102361 ttagaaagcg ttgtgacaaa gtttaattta cttgcgccgt taatgctggc aacaagaatc 3102421 gcgtgcgttc cccataacaa gatcgtacat acggcaaacg tcagtaattg gccgagtgtc 3102481 acctcttgcc cgccgatcga aaacatctca cgtttatcaa ccaagatcgg gaagaacgaa 3102541 gtcaagtaac cggcgagact tgtgatgatc gccacgttac tgatccagct cgccacccag 3102601 tagccccaca ccattgtgaa accggcagcg ttgccttttt tcgggtcaga aaacagcgct 3102661 cttgcataac tttgcggtcc cgctgtcagt tcaggcttgc gaatggacaa gtgtccgaac 3102721 acaagtgcaa tcatcagcac gccggcacct gtcaaaagcc aggcggacgt agctccaaac 3102781 ggactcgcaa ttgaagcaag cgagctcggc aaggagaaaa ttcctgatcc aaccatattt 3102841 ccaacgacaa acgccgttaa taaccaaaaa ccccattttt ttgtctgttc cattccagta 3102901 cctccatgat tctttgtacg gaccagaccc cgagatcata taaacgcaaa aaaagcctga 3102961 acaaaagtcc atgcttaaag aaacacacac ccttgatctc cggatagccc tccgcgaaaa 3103021 agcacgcggc agtcctgcac ttattcagat acagtcccag catagagaag gatcggcttt 3103081 ctccacactt cggcgctgat gccttttaca catgtttaac agcccctgtc agcctagcat 3103141 gtgtgactca tcatccgcgc aacctctacc tcactgagaa agagtgagga tttaattatt 3103201 cagttactcc cagaaggtta tcaaagaaag gatgatctgt caaagggaac agatggaaaa 3103261 tacggataga gccaagccct atccgcatgt ggttatcgat tatttttctt tttttgcaca 3103321 gcttcttgaa gcggatcatc ttttagagct gaaccagcat cttcaagagc tccttggatt 3103381 acgttttttt ctttttcgga acgttttcct ttatctttat taaagaaacc cattcgtatc 3103441 acctctttta aaaaataggt acatgtttaa gatgcctttt tcctgaaaaa ttatgcggga 3103501 tattttttat cgtccaaagt cctgttgatc aaacatacat tctcttgata tatttgtaat 3103561 tcagagattt tttgcaaaag ataaaaggag aagcggcaaa tgacaggaaa aacacacatc 3103621 atgggaggca tcgcttcttg tacggcagcg gcttattatt atggatttga tccagtgctt 3103681 atggctgcgt caggcgcggt tggagcatta atacccgata tctgccacac acaaagcaaa 3103741 atcgggagaa aatttcctat tttatcgaaa gtggtcagct ccgtttttgg ccatcgcacc 3103801 tttacacaca gcctgctgtt tatgctcatc atgtttttta tcacttctac atacattcca 3103861 gataaaaaca tatcagccgg cctgatgatc ggaatggcga gccacttgat tcttgacgct 3103921 tggacggtga acggaatcaa attattattc ccttccacga tccgcgttcg gcttccatta 3103981 tatatgaaga caggcagttt ttctgagcag ctcgtgctag ccggcctgac ccttgcttca 3104041 tgttactact tttatatgct gtttcatggc cgcatgtttt aaacatgagt gctgagactt 3104101 gtctgaaccg gctgttttta gtaggtttta cttaagaagc atttcatgca gatgatcaag 3104161 aaaacgtgag gagtcatatt gatgaaagga accttttttc acaatcagcg gtttttatgt 3104221 ttttcgatct tatttatgtg gatcaaaacg tatgtgatat ataaactcgg ctttgatttg 3104281 caaatcgata ctctgttgga ggagctaatg ctgctggtca acccgctcag ctttattctt 3104341 cctttattcg ggatcggcct gtttctaaaa gaaaacaagc agcgggcctt tttgctgatt 3104401 gccaatttgg ttctgactgt tatcttgatc tctaatacga ttttttacgg cttttatatc 3104461 gattttatta ccatcccggt tttatttcag gccagcaaca tgagcgatat gggcagcagt 3104521 gtaaaagaac tgttccatcc tctgtttatc gccctgtttg tggatttggt ttttctgctg 3104581 ttgttcgcca gaaaaaccaa acacccacag acaaaagccg ctccccacac gatcaaacgg 3104641 tactatgcag cttcctgcgg aatgctttta tgcacactgg cacttgcaga agtacagcag 3104701 ccgaagcttt tggcacattc ttttgaccgg gaaatgctag tcaaaagcat cggcctgttt 3104761 cagttccata tttacgatac aatttctcag actgttaata tcagcgcgaa agcttttgcc 3104821 gatgaagaca gtataactgc cattaaaaac tacacagagg ctgattacag caagcctgat 3104881 caaagcaaat tcggtcttgc aaaggggcgc aatgtcatct ttgtaacact tgagtcgacc 3104941 caaagctttg ttctgaatga aaaagtaaat ggaaaagaaa ttaccccatt tatgaatgat 3105001 ctcataaaaa aaagctattc ctttgatcat ttctatcagc aaacagaaca aggcaaaaca 3105061 tcagattcag aatttatcgt cgctaactca ctgtatccct cccttagcgg cgccgtcttt 3105121 ttcacgaaaa gcgaccatca atttcatacg atgtataaat cgctgaagca gcacgattat 3105181 tattcagccg tctttcacgc taaccataaa acattttgga acagagatgt catgtacgat 3105241 acatttggca ttgaccgctt ttttgatgtt gatgattttc atgtcactcc cgggacatcg 3105301 acaagctggg gcttaaaaga caaagaattt ttagagcagt ccgccaaaaa gctgaaaagc 3105361 ctaccgcagc cgttctacag cagttttatc acgttaacga atcattttcc gtttgagatt 3105421 gatgaaaagg atcagctgat agatgaattc gattcaagca gtgatctgtt aaaccgctat 3105481 gtgaccacgg ttcgctatga ggatgaagca ttgaagcatt ttatcaaaaa actgaaggac 3105541 gaaggcttat acgaaaattc gatgatcgta tttatgggag atcattacgg catttctgaa 3105601 gcccataacg aggcaatggc tgagttttta gggaaagacg aaatcacacc gtatgacaac 3105661 gttcagctcc agcgggtgcc gtttatcata catatcccgg gaatcaccga tcaacagccg 3105721 gaaaccatcc ctgatgccgg gggacaggtc gacgtcaggc cgacgctgat gcatttgctc 3105781 ggcgttgaga caaaaggcga tatccaattc ggcaatgatt tgctgtcggg cgaccgcacc 3105841 ccattcgccg ttctgcgaaa cggcagcttt attacgaacg attatgtata cacaaagaac 3105901 acgtgctata gccaaaaaac aggtgaagtg ctggaagatc aggatgcgtg cctcccttac 3105961 aaggagaaag caaacgaaga actgtctctc tctgataaaa ttttaaatgg tgacctgctc 3106021 aggttttccg aatgaaaaaa tccctctatc aagagggatt ttttacgttt ccaatatcac 3106081 cttgccagtc agcttcgttt catagccgtt taaatgagac agattcgcct tgtagtcctc 3106141 agaattcaaa atctccttca cggctttgag caactgctca ttttttttca aaacaacgat 3106201 atcatattgt tcgtcgatga gcgggataaa atcaacactg cccatatgtg ccgcgtgctg 3106261 tgccccgatt cccgcgtcag cctgtccgct tgaaacttgt gaagcggcag cgtaatgatc 3106321 agtcacgata tcgccatatc ccactacatc agccggattc acaccaagca agccaagctg 3106381 ttcatcaagg agcacccttg cgccagaacc cttttccctg ttgatgatcc ggatatcggc 3106441 tcttttcaag tctttccagc cttgaatgtt tttcggattc cctttttgca catacagtcc 3106501 tgctttgcgg agaacgacat tgatgagaca aaacggttca cctgtcaaaa tccgttttac 3106561 ataaggcgcg ttatactggc ccgtttctgc atcgtacaaa tggaggctga caatgtcaca 3106621 cttgccttga tacatatcaa tcaggctgtt taagcttcct ttgtatttac ggagcggcgt 3106681 ctcctgaatg gcattctcca aatgcttgct gaggatatcc atcgaaatgt cctgtccgct 3106741 gatcatgaca tttggtctgc cgtccggctc agcctcctgc acctgtttcg gcgcttcttt 3106801 tgcagcgatg ggctgagaca ttctcatatt cgttttatat tgctttaaat cttcttcatc 3106861 cacacgcatc tgccttccga cacggtaagc aggcagcacg ccttttttaa tcaagtcata 3106921 aacggtcagc tttgatacct tcagcagacc tgcaacttct tctatcgtat aggaagaggt 3106981 ttcattcatc atcatcactc tcctatttta ttataccttt tcgccgaatg taaaaaaacc 3107041 cacataaacc aaacataatc agttataatt agttatatct aatgataagg ggtgcaatca 3107101 tgtttaagaa gtattctatt ttcatcgcag ccttaactgc ttttctgctt gtagcaggct 3107161 gttcttcaaa ccagtcttca acggacagcg agaaaaaagt aacgttaacc atctcagctg 3107221 ccgccagcgc gcaggatgca cttgaggaaa tccaaaaaaa ttatgaaaaa gatcatcaac 3107281 atataaccat ccaagataac tatggctcat ccggcgcctt gcaaaaacag atttctcaag 3107341 gagcaggagc agatctgttc ttctcagctg ctgaggataa atttaaaaag ctggtggatg 3107401 atggagatat cgcaaaaaaa gacagcactg aattagtcgg taatgaaatt gtgctggtcg 3107461 taccgaaaaa cggagattca cctgtgacaa gcttcagcaa tctggctgaa tcagaaaaaa 3107521 tcgctcttgg cactccggaa tccgtaccgg caggagctta tgggaaagaa tcactgacaa 3107581 agctgtcttt atgggacaaa gtgaaggata aaattgtgta tggaaaagac gttcgccaag 3107641 ttctttctta tgttgaaacc ggcaatgtag acgcaggtgt tgtttataaa acagatgccc 3107701 tagtctcgaa aaaggtcaac attgttgacg aggcaaaagc agatacacac agcccaattg 3107761 tctatccgtt aggaatcgta aaagatacaa aacaccgtaa ggaagcgaag gaattttacg 3107821 aatacctgca atctgatgaa gcaatgaaag tatttgagaa atatggcttt actgccgagt 3107881 agcataagcg cttcagaatt tttcacaccc gttgtgcttt cctttcaggt ggcggcagtt 3107941 gccggaattg ttgtcattat tctcggaaca cttgctggag catggatgtc acgggcatca 3108001 tttttcggaa aaacggcact cgaaacatgt tttatgcttc cgctcgttct tccgcctact 3108061 gttgtcggtt ttattctgat cgtcattttc ggaaagcaca gcttcatcgg acaagccatc 3108121 gagtggattt tccagcagcc tgtcattttc acctggtggg ccgctgtgat cgcctcggct 3108181 gttgtagcct ttccgcttat gtatcaatca gccaaaaccg gatttgctga cattgatccc 3108241 gatatacaag gtgcggcaat ggtagacggc gctagcagat ggaaagtgtt tatccatatc 3108301 tccgtcccgc ttgcctatcc ttcgttactg accggaagca tccttagcct tgcgcgggcg 3108361 ctcggagaat ttggcgcaac actcatgttt gcaggaaaca tccccggtgt tacgcaaaca 3108421 ctgccgacgg cgatatatgt cgcattggat tccggcaaca atacccttgc ttgggcgtgg 3108481 gtcgtctgta ttgttgtcat ttcctttttg atgctgtttt tcattcaaca gaaaaaaacg 3108541 cactaaaaaa actccccata acggggagtt ttttgattaa aacagaagct catcaggatt 3108601 tggaccgaca cgctcatctt tatttaatgc gtcaattttg tccatgtctt cttgagacaa 3108661 ttcgaaatca aaaatatcag cgttttcgat gatacggtgt tctttaatgg attttggaat 3108721 ggttacaact ccatgctgca gatcccagcg caaaatcact tgagccacag atttattgtg 3108781 tttttcagca atctgtgtca gtacttcgtt atccaaaagc tgtccctgca tgagcggaga 3108841 ccacgcttcc agctgaatgc cttgcccttt gcagtaatct cttaattctt tttgcgtcaa 3108901 gcgagggtga aattcaactt ggttcaccat cggtttgatt tcagcatctt tcaacagctc 3108961 ttctaaatga tgaacttgga aattgctgac gccgatcgcg cgaattttgc cgtctttgta 3109021 cagcttttca agcgcgcgcc atgtatcttt atatttatct ttgccaggcc aatggatcaa 3109081 atataaatct aagtaatcaa gctgcagtct ttctaggctt ttttcaaagg cagcaagcgt 3109141 tgtttcatag ccttgatctt cattccacac ttttgatgtg atgaagagct cttctcttgc 3109201 cacaccggat tctttaatcc cgatgccaac gccttcttca tttttgtaga tcgctgctgt 3109261 atcaatactg cgatagccat ttttaattgc cgctttcact gattcagtcg cttcattacc 3109321 attttctact ttaaaaacgc ccagaccgaa ccaaggcatt tcaactccgt tatgtaactt 3109381 tacagtatct tttaaacttg ttggcacttg aacctccacc ctttcactga aatgtaagcg 3109441 tctatattat ctcacattcc tctcagccga taccaataat acgcttaaga ccctcttttt 3109501 gcttcttttt tcacagcaca ggcaaatcca aacactattt ttttcctatt ttaacaatat 3109561 tgagattaca aatacattga gcagggtatg cgtgtagtgt aaccaaatga aaacaaagga 3109621 ggaaacaact tgaaacgtat tcgtatccca atgacacttg ctcttggtgc cgctttgaca 3109681 attgcccctt tgtcctttgc ttccgctgaa gaaaatcctg ctccgaagat gtcgcagaca 3109741 actactgctg gaacaactgc cgctgatgta ggtttaaacg tcaacctgga tgtacttgga 3109801 attgccaacc agatcgctga tgccatcaaa tccgcacaga atagggatgg ctttgtgaaa 3109861 aacctcatgg agtcttcctt ctacgcgtcc ggccaaaaat ataacgtcat ggtctttaat 3109921 ttaagccagg aatatgaaga tcatttgaac ggtgtgcaat tttacggctc agccgtttac 3109981 gacggcatta cgtatggcat ttgggtattt gaagatggaa cctttacaaa caaaggcgat 3110041 ggcggctgga tcaactgggc cttcagaggc tggttcgacc gggatggcag cactgtcgca 3110101 tttcatcgcc cttaatataa aaaaagctgg cgctctaacg ccagcttttt ttctgcattt 3110161 attcgccgcc ttcaagcatg gcggcttcga catcattaat gtattggcga agctcatggg 3110221 agatgtcccg ggaaatttcc ctctcttcga agagcgtttg aatttcattt ctgatcgcct 3110281 gcacagcctt cagcttcact tccagcttct gattttcaaa atgggcactt gattttaact 3110341 catgatggct gtgctccagc ctgaaaatta actgcttata gaatgtaatg acagataaaa 3110401 acacttcttt atgctcatcc gtcttatgtt tttccagata ttctatcgct gcttttgccg 3110461 ttttcactct tgttgcccgt atcaatcccg cttcatttaa aatcgacatc tccggctttt 3110521 tatgttcacc gaagaaaatc caatacatca gcctcttgag ccttgttttt gataacccga 3110581 ctttaaacgg gttggcatac aaaatttcca actcgttaaa tcgttcttgc agcacatttg 3110641 ctgtttcttc cgggatgtct ccccgctcca gcattttcat cagcgcctct tgctcagcct 3110701 taaccccctg cgcacggact tttcgctcgt gcttcttaat gcgattagat gatgtatact 3110761 gctgaaaacg aagatttttc attttctcat tgtattcagc tatcaccgca agagaggccg 3110821 ttttgtttgt ctcattcatg tcctctttaa tcgtttgaag ggctgttttg atcaacttgc 3110881 gtctcgccgt cagcagcttc ttatttcgtt cctcgtcctc ttcttctttt tcagtcagaa 3110941 ttggcagcac aacggtggca atgacaagcg tgcataaaat gacgccggct gctaaaaaga 3111001 gaatcagatt tctttccgga aacggcgtac cgtcctccag gaaatacgga atggaaaaag 3111061 aacctgcaag cgttactgct ccacgcacac cggaaatcga aattaacagc gtcgaacgaa 3111121 gacccggttt atagatgttc tgatctttat taaagaacca tttgccgttc cagaagaaca 3111181 gcacccacag gaatctaagg agcattaatg taaatgtgat gactaggata tagccgatca 3111241 ccttcatgtt gctgatggca gtgtcgttaa agataacaga aataacatca gggatttgcg 3111301 tgccgagaat aacgaagacc aggccgttca aaataaataa aataatgttc cacgtacttg 3111361 aggagacgat ttgcagcttg atcatcgttg attccagacg atcctgttca accgcatggg 3111421 taataccgcc agctacaaca gctaaaatgc ccgaaacgcc gatttcttca gctgccaaat 3111481 aaatcacaaa cggcgtcaga atttgaatca gcatatgcat cgtgacatcc tgcatgccaa 3111541 ggcggcgcag aaataggcga aaacgaataa tcaaaaatga aatgacaacc ccgcacagca 3111601 agcctccgag agaaataaag acaaagctga cagccgcttg tgctaatgaa aatgcaccag 3111661 tcactgccgc tgcaatcgca aacttaaagg ccaccagacc tgatgcatca ttcatcagcc 3111721 cctcaccttc cagcaggcga agaatccctt ttggcatttt cactcttcct gataatgcgc 3111781 tgacagcgac gacatcagtc ggtgaaagaa tggccgcaag tccaaaggcc gctgccagcg 3111841 gaatagcagg aatcatccag tgaatcgtgt agccgcctac aatcacagtc gcaaatacaa 3111901 ggccgagtgc aagcaataaa atcggagccc ttaaattcca aagctctgcc cgcggtgtcc 3111961 tctttccatc attaaatagc agaggcgcga taaaaagaac aaaaaacaat tcggtgttta 3112021 attcaaaatg aagtccctgt ggaaatgagg cggcaagaat cccaagagcc acttgaatca 3112081 gcggcaccgg aataaacgga ataaaccggt tcacgatatt agaaatcgca ataatcgtta 3112141 ataatacgag cacaactaaa aatatgtcca aatgcatgac ctccttcgtc tgttgtgtgt 3112201 cggcatgatg agccaaaaaa tctgtttgtc taaaagccct tgagctaggg tggccttgca 3112261 tccgctatgt ggtttcgcag gagttctctc cacacttgtc ttcttttata gtaccctttt 3112321 tagggtattt tttctcatga tatgctcaca gtgaactttt ttgcagaaga gcaaattata 3112381 gaaaaaagag acaggaagct actccctgtc tctcgtcttt ctttctcaat catgaaaatt 3112441 cgtaccgtca gttgttgctt taataatgcc cgcgcgaatg acaaagtcac cgaaatgctc 3112501 gccttcctcg cgttctttcg catagcggga aagaaggatg cgcagctcgc ttaaaatgtc 3112561 tgcttcaccg atgttttcac ggtacatttt gcttaaacgg cttccgtcaa acgcagcgcc 3112621 aagatacata ttatatttgc ccggcgcctt tccgataaat ccgatctcac cgagtgcatg 3112681 acgtgcacag ccgttcgggc atcctgtcat gcgaatggtg atttcctgat cacgaaggcc 3112741 gttttcgtca ataatctctt caatcttatc taacagggtc ggcaaataac gttctgcttc 3112801 agccattgcc aatccgcagg tcggaagagc gacgcacgcc atcgagctgc ggcgaagcgc 3112861 tgaatagtgc ttgccgtcag ttagtccgta ctgttcaatt aaagcactga tttcttcttt 3112921 tttatcgctt gaaacgttcg caatcattaa gttctgattg gctgtcagcc ggaactcacc 3112981 tgtatgaact ttggcgattt cccgcaagcc agtcatcagc ttataatcat cgtaatccgt 3113041 tatacggccg ccttcgacaa acagcgtgaa atgccattta tcctcgatgc cttccaccca 3113101 gccatagcgg tcgccgttat gatcgaaatg atacggcttc gcttcttcca ggctccagcc 3113161 gagacggttt tccaattctt cttttacgtt ttctaaaccg aggcggtcaa ctgtgtattt 3113221 gaaccgcgca tttttacgga cagaacggtt gccgtaatca cgctgaatcg taatcgtttt 3113281 ttcagcaacg tcatacattt gctcaggccg gcagaaaccg atcaccttgg ctaattgcgg 3113341 atatgtcgca gtatcgccat gcgtcattcc cataccgccg ccgattgcca cgttaaaacc 3113401 gatcagcttg ccatcctcga caatcgcaat gaatccgaga tcttgtgaaa agacgtcaat 3113461 atcattagac ggcggaacgg caataccgat tttaaacttc cgcggcagat agagcggtcc 3113521 gtacattggc tcgacttctt cctccggcgt gccggcaact ctttcctcat caagccaaat 3113581 ttcatgatat gctctcgtcc gcggcagcag atcatcactt aattttttag accactcgta 3113641 tacctctgag tggatttcag attgataagg gtttgatgca cacatgacgt tacggtttac 3113701 gtctccgcag gctgcgatcg tatccaaaag tgctgagtgg atcgtctgaa tggttttctt 3113761 catgttccat ttcagaattc cgtgcatttg gaatgtttca cgtgtcgtca attttaatgt 3113821 gccgttcccg tatttctggg acaggtcatc catgacaagc cattgttcag gcgtcgagac 3113881 gccccctggc atacgcacgc gcagcatgaa ctgatatgcg ggctcaagct tctgcttttg 3113941 gcgttcattt cggaggtcgc ggtcatcctg caaataactg ccgtggtgtt tcatcaggcg 3114001 gttatcatca tccggaattc ccgcactgat tcgatcgagc atcacttctt tcagcgtgcc 3114061 gcgcaaataa tcactttctt ttttaatgcg ttcaacatca cttggagagc cgtccggtgc 3114121 ttttagaatt ttggtcacca tgttgaaaaa ctcctttcaa gtcaaatcaa tatacatcac 3114181 gctgatagcg tttttgctgc tgcatatcgg caagataagc ctccgcctct tcgcggctca 3114241 tattgccttc tttttcgata atttcaagca atgtgttatg gacgtcatgc gccatgtgct 3114301 tttcatctcc gcaaatgtaa acagccgctc cttcttgaag ccattcaaac aattctgcgc 3114361 tatgttcaag catgcggtgc tgcacatata ctttttcttc cgtatcacgt gagaacgcca 3114421 catccatttt tgtcagcaca ccgtctttga gccaattctg ccactctgtc tggtaaagga 3114481 aatccgtgac aaagtgctga tcgccaaaga acatccatgc ctttccttcc gctcccgtct 3114541 cctcacgctc ctgcataaac gaacggaaag gtgcgacgcc tgtcccaggg cccaccatga 3114601 taatcggtgt ttcagggtct ttcggaagct taaagttttg attgtgctgt acataaaccg 3114661 gcagtgtgtc tcccggctgc agtcgttccg cgcacaaaat cgagcagacg ccttttcgtt 3114721 cacggccgtg cgcatcgtag cggactgcgc cgattgttaa gtgcacttca tccggatttg 3114781 cggataaact gcttgcaatc gaataaaggc gggcaggcat ttttcgcaaa atcgagacaa 3114841 actcctgcgc agatacacta aatgggccat agtcacggac gagatcaagc aaatcgcgcc 3114901 cttcaatata ggcttttaca ttctcctcat ttcccggggc taaaagctct ctaagctcat 3114961 cgttccctgt cagctgggct gcctgttcaa gaagcggttt tgtgagaacg gtaatctcat 3115021 agtgagaaat cagcgcttct ttcagcggtc ggacatcacc ttgcttatta agcgtcacaa 3115081 tttcttccgg gtcccaattc atttccttaa ggagcagctc gacaagttcc ggatcgtttt 3115141 ccggatagac gccgaggctg tcaccaggct cgtaagtcag gccagatcct tcaagagaca 3115201 gctccacatg gcgtgtttct ttatttgatc ctctgccgtt taaatttaaa ttttctaaca 3115261 cttcagcccg aaacgggttt gttctggaat acgaagactc accggtttgt gacgcagccg 3115321 ccggcgcagg cgcggcgctt ccgcccccag cttcatttaa tcctttcaat acaccctcaa 3115381 gccattcggc tgccggttca tcatagtcaa gatcgcaatc aacgcgcgga gaaatccgtt 3115441 ttccgccgag ttcttctaag cgttgatcaa attctttccc tgtctggcag aaaaattcgt 3115501 acgaactgtc accaagcgcc aaaacggaaa agcgcaggtc ttcaagctta ggcgcccgtc 3115561 ttccgtgcag aaattcatga aacgacagcg cgttatcagg cggctcgcct tctccatgcg 3115621 tactgacgac gattaaaaga ttggttacct tcttcagctg attcggctta aaatcgctca 3115681 tggatgagac ggtcacttga aaaccgctct gttcaagctg cttgccggca ttttctgcaa 3115741 gcccctgtgc gtttcccgtc tgtgaaccat aaagaacggt cacttctttt gaaacggccg 3115801 gtgccggtgc ttccgctgac acagctgccg ccggcgtacc cgcagcttct tgggcggaaa 3115861 cagattgagc ggataaatat ccgctcagcc agattttctg ggattcggtc aaggtcggca 3115921 gaaggcggtt aaggagctct gcctgctcct gattaaacgg actgttcatt acctgaagtt 3115981 gcaacgtatc cacctcacaa agttataaac tgatcgaaaa ttgcatctaa ttgaacttta 3116041 ccggaatact aggcttaagt aaaatatatt tacatgatga taactattaa gaatcctaat 3116101 gataaaacgg ctatgcttca tgtaaataga aaaaagagaa ggactccctt ctcttcattc 3116161 agcaatctga tataagtgag gcggcacagc ggttacaaac ggactggctt cacctgtata 3116221 aaataccgcc agcatgtgca tcgcacgggt gcacgcagta tataaaagcc tgcggtcgtg 3116281 ctctgtatga tagtgttctt cagatgcatc atagacaagc actgcgtcaa attcaattcc 3116341 cttcgctaaa tacaccggaa tcacgcaaac acccttttga aatggttgat tttctttatg 3116401 aatcaggcga acatctgtat attcactcat gtgggcgtgc gcctgtatgc attgatgcgc 3116461 agtcttgcag atgacggcta ttgtttcgtg cccttttttc ttgagccggc caatttcttg 3116521 cgcgagcttt tggcaaaggc tctcatgtcc ttcagttttg acaacgagcg gcatttcccc 3116581 gcttctatta aacggctcaa tatccgctcc atcttgaagc atcgctttgg taaactcgac 3116641 aatctgcctt gttgatctgt atgttctctt taaacgaaca tactcagcag gctcatcctc 3116701 aaagcacgca tccatacgct gatccccgtt tatggtatgc gcgtagatgg actgattgat 3116761 atcaccgagc actgtcatgc tggcagccgg aaaaatgctt ctcatgtaag ccatctgaaa 3116821 cggtgaatag tcctgggctt cgtcaataaa tagatgtttg attttcgtat ttttctttct 3116881 gccctcaatc agatcctgca tataaagaaa cggtgccgcg tcctcataga gcaatttatt 3116941 atccgtaaat gccgaacggg tcagctcacc tatcgcatcc atcttctcat gttgaaattt 3117001 tcctccccag ccagaaaaca attgcaaata aagttgtgta acatcaagaa atgcaaggag 3117061 cctgactgcc tgtttgagcg gtttgaaagc ttttttcaca atgatggcgg caagcagctg 3117121 ctgctctctt tgataatcgt taaacgtact ctcgctgaac cgtttccttt cctgcagttt 3117181 tttgtacacg tccaagtagt cctctttgtc aagcagctca gcttcatgaa caacccaatc 3117241 ctttcgccgt tcctttttct caagcttgtt aagctcactc agcagccact tcgcggtttg 3117301 ctccatccga ttcggaatgg agtgattttg atccaatgag taaaaatagg attgaatttg 3117361 ctcctttgtg atcagctttt gtccgcggaa tataatattt ttaaaaatca tcccttcaga 3117421 ggaaagccgt gtgacgtatt cattaatgaa ttgctgaaag gataaacccg ccttccatgt 3117481 gattcctgca agccttgttg gaaaatcgcc tccctttgtt tcggtcaggc aatattcgag 3117541 ctgatcaaag gggctttcac atttgaactt gcggccaaga cgatgctcga tatattcctg 3117601 aaacgtcgcc tgctccatat tctcttctcc taactccggc aaaacagagg agacatagct 3117661 gttaaataag aagttgggtg aaaacaaaac gatttgtccg gcatcaatga caccgcggtg 3117721 cctgtataac aaataagcga cacgctgaag cgcagccgat gttttcccgc tgccagccgc 3117781 tccctgcacg atcaggatct tgcttttttc attacggata atctgatttt gttctttctg 3117841 aatcgtagac acgatgtttt tcatttgggt atcagagtga tggcttaata cctcttgcag 3117901 catttcatcg ccaatcgtca tatcggtatt aaacatcgcc ttgagagtgc cgtttttgat 3117961 cataaactgg cgtttcagca ccatttcccc ttctatcgtt tcaccgggca cctcgtactc 3118021 cgcttttcct ggggaataat tgtagtacaa acttgatatc ggcgccctcc agtcatagat 3118081 cagaaagtgt tcctccttct catccaaaca ggaagctaaa ccgatataaa ttcgctctgc 3118141 ctgctcctcg ccgttttcaa taaaatcaat ccggccgaaa taaggcgatt ttttcaattg 3118201 atgaattcgt ttgagctgct gatccatgcg ccgatgattg tgttcccgat cagacagcag 3118261 ctctgcctgc tgcttaatgc tagccatcgt ttcaatcgct tcatgggcat catcaaaatt 3118321 aaccttaaca tcctcccaaa agctttttct taatccgatg atatcatgct tcaacccgcc 3118381 cgcagacgtt tccagaaacc gctctttttt ttcgagctcc ttcagcacct catctattct 3118441 cgactgctct tccttccatt ccttatcctg ctgattcatg aacggcacct ccagaaaata 3118501 gttgacaaac atagatgaaa tactgtaaaa tataattgga tacatatatt aaatatatga 3118561 tgcaaactgg caaatacaat ttataatagc acattcaccc aataccaatc aaggtttggg 3118621 ttatttatat tatgcagaaa aaaaccgatt tcacttcgaa atcggttttt ttgctattaa 3118681 ttatctaagc gaaaagaacg gtttggcagc ttccaattaa acatatagga acaaacccgg 3118741 caaacaacga gcacgaaaaa cagaacgtat aagccgaacg agttccccag ccagcccaag 3118801 ccgacgatta aaccgccgag cgccgcccat accgcataga tttccgcttt cagcacaagc 3118861 ggtttgcgcc cggcaagaag gtcgcggatg atcccgcccc cgcttcccgt cagcaccgca 3118921 gccacgatca cggcactaag cggatggccc attttgacgg catacagtgc gccttggata 3118981 gcaaaggcag cgaggccgat cgcatctgat aaattgcccc acttattcca atgcttcagc 3119041 agcagcttcg gaaacagaaa cacaattgta atagataaaa gcgcgatttg aaagtacgct 3119101 ccctgctccc atagcgctga caccggaaca ccgatcagca aattgcggat cgctcctcct 3119161 ccaaaagctg tgacaatccc taatatataa actcctaaaa tatcatattc ctcttccatc 3119221 gcaacaattg cgccgctgac tgcaaacgca atgatgccaa tcacactaag cagctcccaa 3119281 gccattctga tgactccctt ttatgtttgt taaattttct gacgacctct agattttata 3119341 atcgctccag cgtaaaatca ataacatttt catgagaaaa aaagataaat ttagagggaa 3119401 tacggctatt gctgatggac atgagtttgc gaaattaaaa aagcgcccgg catacgcggg 3119461 cgcttttttt gttattcaga tttttcgcct ttcagcaggc acataaaaat gataatcagg 3119521 ataaaagcaa tcagggccag gaatggaatc gtaataaaac caaaccagtt aatatattgg 3119581 cccgagcacg gcacgccgct gacacatggc ttaatgccgc taaagccggg cactttttgc 3119641 tctaagtaat gcatgatcga aatgaatgcc ccaataatcg ccatcgggag cacatatttt 3119701 ttcactcgtg tgtccccttg aaaggtggcg atgcctaaaa tcaggacgag cggatacatg 3119761 aggatacgct ggtaccagca cagttcacat ggaataaact ttctgatttc actgaaatac 3119821 aggctgccca gcatagcgat aagagccaca acccaggaag catataaaaa tacgattcta 3119881 tttttcatat tgttacttcc ctttcagctc tttttctatt gtctctttga tttcatcata 3119941 atccgcaaaa tttttgatca ctttatcatt gacgtaaatc gtcggtgttg cctgtatgtt 3120001 cattttttga ttaaggtcag aatccttttc cacttgagaa gcgaatgttt ccttatcaag 3120061 attttccttg agcgtctcag gttttatctt tgtggtgctt tttgcaagat caccaaggag 3120121 gcctggggtt acccattcct gttccgtatc cggctgtttt tcgaacagct tttcatggaa 3120181 atcccagaaa gagtcagggt cttccttcca tacttcttca gatgcaagag ccgctaacct 3120241 tgaacctttt ccatggaaca tgacgttcac gaaagaaaat ttcacatcgc ccttatcaat 3120301 aaagtctttt tgtatttttg gaaagatgtc actgttaaac accttgcaag acggacattt 3120361 gtaatctccg aattctacta cagttaccgg tgcatcgtcc ttgccaagca caggctgccc 3120421 tttgatagac ggctgtccgg acaccgcatc attgccttgt tccgttttgt tattaatgat 3120481 gacaatggct gctagcaata caacaaccac aaccgtaagg atgaccgcga atttcgcaga 3120541 agactgctgt ttctttttca ctccgacacc tcatcgtttt aaaattaaaa aagaagcgga 3120601 tcgcaattga cccacttctt tattttaaca agacaagcgc tgataagaaa accccgaaaa 3120661 aatgaattct ctccgacaat ttatttgttt ttgagacgca tgacgcgcat ggcgttcgcc 3120721 acagcaagca gtgtaacgcc gacatctgag aaaaccgctt cccacatggt cgcaattcca 3120781 aatgcaccaa gaatgagaaa gatcgctttc acacctaaag caaagccgat gttttgccac 3120841 acgattcgcc gtgtccgttt cgcaatccga atcgcttctg ctatttttga cggctgatct 3120901 gtcatcagca cgatgtctgc ggcttctacc gcggcgtctg agccaaggcc tcccatcgca 3120961 acccctatat ctgcgcgtgc aagcaccggc gtatcattga tgccgtcacc gacaaaaatg 3121021 agtttttcac taggcaaaag cttagcttct aatgcttcga cctgcgcgac tttatcttgc 3121081 ggcagcagct ctgcatatac ctcaccaatc ccaagctgtt ttccgacggc ttctcccgtt 3121141 tgtttcgaat cacccgtcag catagctgtc tgtttgatcc caagcgactt cagatcagca 3121201 accgcctgtg ctgcgtcttc ctttatctca tccgctatga tgattgctcc ggcatagcgt 3121261 tgatctacag caacgtgtac gattgttcca gcattttcat ccgggacatc ctcaatttgt 3121321 tctctttcca tgagcttttt attcccagca aggatctcag ttccatttac ctttgcaaaa 3121381 atgccgtgac cggagatttc ttcgtatgac tcaatctcat cggaggaaag cattttcccg 3121441 taagctttac gcacagattc agcaatcgga tgctgtgaat gaagctcagc gtatgccgcc 3121501 gcttcaagta atctatcctt tgtaaaacct tccgcgggtt tgatttctgt cacttcaaag 3121561 ctgccttttg ttagtgttcc cgttttatca aacaccgcgt atttgacttg attcaaagct 3121621 tctaaataat tgcttccctt tacaagcact ccggcctttg aggccgctcc gattccaccg 3121681 aagaaaccga gcggaataga gacaacaagc gcacaaggac aagaaatcac taaaaagata 3121741 agcgcgcggt acacccaatc ggaaagcgcg gcgccagaaa gaacaagcgg cggaacaaag 3121801 gccagcaata ccgcaatgat caccacagca ggtgtataat acttggcaaa cttcgtgata 3121861 aagttttctg tccgggcttt acggctgctc gcattctgaa ccaagtctaa tatttttgat 3121921 actgctgatt cctgatagcc ctttgtgact tcaatatgca gaacgccgtt ttgattgata 3121981 aagcctgaca ttacatcttg tccttccgca gcttttctcg gaacggactc acctgttaaa 3122041 gcagatgtat caaccatcgc tgacccttgc acgaccttac cgtccagggg tatgctttct 3122101 cccggattaa ccacaatgat gtctcctgtc tgaacgtcct ccgacgaaac ctgttcgatg 3122161 ccgttctttg ttttgagatt ggcgtaatca ggccgtatgt ccattaacgc actaattgat 3122221 tttctggaac ggctgaccgc ggctccttga aaaagctcac cgatttgata aaacagcata 3122281 acggcgaccc cctcagggta ttgctgaatc agaaaagcgc cgattgtggc aagagccatt 3122341 aagaaatgct catcaaacac ctgaccgcgg atgatgtttt tgactgcgcg gattataatg 3122401 tcaccgccga taatcaaata agcaccgagg aaaaggaaaa attcaatggt tcccgactga 3122461 accaaatatg ccgctgcgcc gagaatgaca gccgccgcca ttctgatcag catattgacc 3122521 attcgattac gatagccatc atcagctgat ttctttatat gcttttggcg aaccgttaca 3122581 tgcggatcaa ttgatttcac ttttttctct actttattcg tgacccattg ctcttctttc 3122641 ccatcggctg agacagttaa ggtgcttgcc gcaaaattta ccgcgcatcc gttaatgcct 3122701 tttatgcctt tgactccatt ttcgattttt cgggcacaat tgctgcaatc caaaccgtcc 3122761 agaacatatt cctgtttcac tagtctcacc ttaccttccg atttagggtt ccctcttcaa 3122821 agcgtatcaa tgagtattgt atttatttta tatatatgag catatactca tatataagtt 3122881 acacctatta tatgttgttt tccaagaaag tgtcaatgaa aaacaaaaac cggcatatag 3122941 ccggtttttc attttacttt ttgcagacga agagcattca gaacaacgga aacggagctg 3123001 aatgccattg ctgctcctgc tatccacggt gctaaaaatc caagtgctgc gattgggatg 3123061 ccgaggctgt tatagccaag cgcccagaat aagttttgtt taatgttttt cattgtcaat 3123121 ctgctcatgc ggattgcgtc ggcaatgctg ttcagatcgc cgcgaataag tgtaatgtct 3123181 gctgtttcca tggcaatgtc cgtgccagtt ccaatcgcca tgccgatgtc agctgtggca 3123241 agcgccggcg catcgttaat tccgtcgcct accattgctg tctggcggcc ttctttttgc 3123301 aagcgggcga tttccgccgc cttttgttca ggaagaactt ccgcaatgat attcgcaatt 3123361 cccgcttcct tcgcgatggc ttctgcggtt ctgcgattgt ctcctgtcat catgatgaca 3123421 tcaagaccca actctttcag acgggcaaca gccttccgcg acgtatcctt aatcgtatct 3123481 gcaactgcta ctagccccgc tgcttctcca tcaatggata caagcataac tgttttccct 3123541 tcggcctcta gctcttccat ttgggcgaga agagccccat gctcaacctg ttcgctctcc 3123601 attaattttc ttgtgccgac gagaatgctt tttcctccgg cttcagccaa aatgcctgcg 3123661 ccgacttttg cttcaaagcg ggtaagtttc ggtatctcaa gccctttatc tttcacgcca 3123721 gcaataatcg cttcgccaag cggatgctct gatcccgttt ccgctgccgc tgcaaattga 3123781 agcaaatctt tttcttcaaa acggccgaat ggaatggcat ccgtcagacg cggcttcccg 3123841 tttgtcacgg ttccggtttt atcaagaaca attgtatcga gacgatgtgt tttttctaaa 3123901 tgctcgccgc ctttaaataa aatcccgaat tcagcagcgc gtccagatcc agccattatg 3123961 ctcgtcggag tggcaagacc gagggcgcaa ggacaggcaa tgacaagaac cgcaatgaac 3124021 ttgctgatcg cttcggcaaa atcgccagga gccgcccaaa gataccaaat gagaaaagtg 3124081 agaaccgcaa tccccaatac aatgggtaca aaaatgcctg aaatctggtc agcgagacgc 3124141 tggatcggcg cttttgaccc ttgtgcttcc tcaacaattt tgatgatatg agaaagcgca 3124201 gtatcctttc cgacgttgac agctttaatt ttcagaaagc cgtttgcgtt aacggttgaa 3124261 cctgtcacgc tgtcaccagg atttttgtca acaggaagac tttctcctgt aatcatcgat 3124321 tcgtcaaccg ctgaacggcc ttcaaccact tctccgtcga caggaattcg ttcgccaggt 3124381 ttgacgtaaa caatgtcatt aacaagcact tcgtcgatcg ggatgatttg ctcctgtccg 3124441 tctcttacaa cagtagctgt tttcgcttga agcttcatca gctttttaat cgcatccgag 3124501 gaacggcctt ttgcttttgt ttcaaacaac ttgcctaata aaatcagcgt cagcaaaatc 3124561 gcgcttgttt cataataaag gccgtctgta tgcccgtgag agccaatgct ttgaaaagtt 3124621 agataaagac tataagcgta agcagccgtc gtaccgaggg cgaccaatac atccatattg 3124681 gcgcttttat ttctaagcgc cttatacgca cccacataaa acggccagcc gatcagaaac 3124741 tggactggtg tcgccagcgc aaactgcatc cacggattga gaaatatatc cggtacccaa 3124801 atgaatgatg taaatgtaaa atggctcacc atcgcccaaa gcaatggaaa tgacaggaca 3124861 gctgaaaaaa tcagtctcgc cgtttgcttc cgttcttctt tctttttagc agcagcctca 3124921 ctgtcctgtt cacccttcaa ctttagctta tatccaagct tatctaccgc ttctttcaaa 3124981 tcgctgacag acgcttcttt tggattgtat tcgaccgtaa ctgtttctaa agcgaagttt 3125041 actggtgcat ttgcgacgcc ttctattttg ttaagccgtt tttcaatccg attggcgcaa 3125101 gccgcacagg tcatgccctc aatatcgaat tcagcttttt ctgtaacgac gtgatagccc 3125161 agcttctcta ttttttcctg aatcgctgca gtccctgttt cagcaggatc gtagattaca 3125221 tttgatgttt ccgttgccag attaacattt gcatccgtga caccgggcat ccgcttcagg 3125281 cctttttcaa ttctggcagc acatgccgca caggtcatac cagagacctg catcgcgatt 3125341 tccttttgtt cactcaacat actcactcct ttatatacac ctggggggta tataaaaatg 3125401 aaagaaatat cgcgcctccc taaaggcgcg ataccttgaa tcacttggct acgtcatagc 3125461 cctgatcttc tatcgcatcc gcaatatctt tgactgatac tttgtcagca tcaaacgaaa 3125521 catcgacttt acccgcttcc agattgacat gaacggcact gacgccgtcc agttctccta 3125581 cgcttgtttc tactgctttg acgcagtgct gacaagacat tccttcaact tgcaatgttt 3125641 tttgttccat atcaattcct cctgtttatt ctttctattt tcatcctacc atacccccgt 3125701 agggtattac aataaaaaac gctttatgat tttgtgaact ttttaaatac gtccaaaagc 3125761 tcagaaatgg cctgttcccc gtctccgctt ttgatggcat ctgctacaca atgatgggca 3125821 tgatcctcaa gcaaatgaag cgccacattt ttcattgccg cctgaacagc tgaaatttgc 3125881 acaagaatat ctacacaata tctgtcgttt tccaccatgt tttgaatgcc tctgacctgg 3125941 ccctcaatcc gcttaagccg gtttgtaatc tgatcctttt ctttcgagct tttatggttt 3126001 aatgttttat gttcgttatg cttttccatg cgtacacctc tgtttaatga tattaattcc 3126061 cattatactg attgtccaaa cggttgtcta agcatgccga cgcaaaaaat gaatcagtta 3126121 ggttttacca tttgatcagg agggtatata cttctgttga taacgctttt aaaggggaga 3126181 agaaaagtgg atacgatcaa ggttggaata ttaggatacg gattgtccgg ttctgttttt 3126241 cacgggccgc tgctggatgt tctggatgaa tatcaaatca gcaaaatcat gacatcacgg 3126301 acagaagaag tgaaacggga ttttccagat gctgaggttg tacatgagct tgaagaaatc 3126361 acaaatgacc ctgccattga gcttgtcatt gtcaccaccc cgagcggcct tcattacgag 3126421 catactatgg catgcataca ggccggaaaa catgttgtga tggaaaaacc aatgacagca 3126481 acggccgaag agggggaaac attaaaaagg gctgccgatg aaaaaggcgt attattaagc 3126541 gtatatcata accgacgctg ggataacgat tttttaacga ttaaaaagct gatctctgag 3126601 ggatcccttg aagatatcaa tacatatcaa gtttcctata accgctacag acctgaagtt 3126661 caagcgcggt ggcgggaaaa agaaggcact gccactggta cgctgtatga tctcggctcc 3126721 cacatcatag accaaaccct gcatttgttt gggatgccta aagccgtgac tgcaaacgtg 3126781 atggcccagc gggaaaatgc cgaaacggtt gactattttc atttaaccct ggattatggc 3126841 aagcttcaag ccattctata cggaggatca atcgttccgg caaacggacc tcgttatcaa 3126901 atccatggaa aagattctag ctttatcaaa tatggaattg acggacagga agacgcactc 3126961 agagcgggaa gaaaaccaga ggatgacagc tggggtgcgg atgttccgga gttttacgga 3127021 aagcttacaa ccattcgtgg ctccgacaaa aaaacagaaa cgattccatc agtaaatggc 3127081 tcctacctta cttattaccg taaaatagcg gaaagcatac gagaaggtgc tgcgctgcca 3127141 gtcactgctg aggaaggtat taatgtcatc cgcatcattg aagccgcgat ggaaagcagt 3127201 aaagagaaac gaaccattat gctggagcac taaaacaaaa gcctccccaa ataaggggag 3127261 gctttttcat tagaatgttt ttcctgcttc tttcgcacgc gcaatcgcgt cttctttgat 3127321 ttgctgtgct ttatcaggct ccgcattatg tccctctacg aaaatgccat cgaatgatgg 3127381 tacgccgaag aagttcatca tgatgccgat gtagcggtgc cccatttcca tctcagccgc 3127441 agggccttct gaatagtagc cgccgcgcgc ttggatatga attgcttttt tatcagttaa 3127501 caagccgaca ggaccttgtt ctgtgtattt gaatgatttt cctgcaacag caacagaatc 3127561 gagatacgct ttcatcactg gcgggaatga gaagttccat aaaggagtaa caaatacgta 3127621 cttatcagct gatgcaaatt gatcgctaag ctctcccaaa cggcctactt tcgctttttc 3127681 gctttcagaa agctcttcaa agcctgtacc tgactgaagc tttccccatc cgctaaatac 3127741 atctgcgtca atgtgcggaa tgttttcttt gtacaaatcg atatgtacaa cttcatcatt 3127801 tggattcgct tctttgtaag attcgataaa tgctttacct gttgccatac tgtacgaagt 3127861 tgcttcgtca tgtggatgag cagtgatata taatactttt gccattttta ccagcccttt 3127921 cgtttttaaa aatcacacat caattattat catacagatg cataatgatt attctgtctc 3127981 tcttagactt tattatagag acaaagaaat ttactttcaa gtaaaacatc tcgaattaaa 3128041 gattatttaa ctttcccaaa cagcttactt ttcaaaagct gttctcaagc cggaatacag 3128101 cgcggacaat tctttactga tccgaggata atgagggaca tgcggcactt gaatatccgc 3128161 aggcatcctt ttcatgataa aggattgctc agcctgttca aaaaacgccc gcagctggtt 3128221 gatctcttca tcagaaaacg gagcagacgg acggcggtga gcttgcgccg agagcaaata 3128281 gtaccctaag tgctgagcac cggaaatggc aggccagagc gcatccgcat tcgcgtgagg 3128341 aaactcgcca agcgccttgt catacgcatc ccgaagcctg acaagactca cccttaactt 3128401 gtgttcgtcg gcaatttgcc cggttaacag tttctccata aactgccctt ccagccggat 3128461 gacattccgc acaagttctg gcagccgctt ggttgaaaac cgccgccaca aaagcattgt 3128521 tcccaacagc ccgatcacgc tgccgacagc tacatcagtc agcctcgcta tcataaaata 3128581 accggcgccc gccccgccat gcatactttc tgtgataaca agcgcatttg cggttaaaaa 3128641 gggaacagcc agcgcataat tgcggacgat cagcatctca agaagacatt gcagcgctgc 3128701 aatacaaaac gcaatataaa caccgcccgg cttaaaaaac aggattgcgc ctgccagtat 3128761 aacaccgatc accgttccgg ccgaacgctg aatagccctg tgaagcgtaa aaacaacagt 3128821 agtgccaagc atgaccgctg ctgccgaaag cggaatccaa taggagcgtg caaagccgaa 3128881 tgcgagggca aacatatcgg cggcaaacag aacaattccg tactttaacg ctctaatcaa 3128941 aactggagac ttccagtcaa aggcatttct caaaaagtaa aaagaggatg gcaggcggct 3129001 tggttccccg tcaagctgct tatcaaaacg tcctgaagcg atatacaaaa cctcattgat 3129061 ttcttcaaac agcttccgcc taggctcaga ttcattttca ttaatctgaa acgtattgaa 3129121 aacccgtgca ttcgcaagca tatctccggt ttggcgaagt gccttttcaa tctgcgcggt 3129181 ctctctgtcc ggcgtttcag ctgaaaaatg aataatggca ataaatatgt cgtcagcttt 3129241 ctcaaggagg cgaaaaaatc gttcatcatg ccgcgatttt ttccgtctgt tccctttccc 3129301 aagaaccgtt tggcgggctg ttctaagcat gagcaccgtc tgatgctgtg cgttatgaaa 3129361 acctggcgtt ccgacggctg aaagacatgc agccagctga tgatatgttt tttgcagcac 3129421 cgctccctcc ggtccatgtt tgttccataa ccagccgatt aaagcgatac ccatggcgaa 3129481 aatgccgccg agaaacgtca gtcccgctct gaacagcgct tgtgaaggat cggccggcag 3129541 cccggaactg actaaaaagg caaggacaaa aaacatcggc gcagggcctt gaatgccgag 3129601 cgcgctaaaa ataaacatcg ccgctgcacc gatcagcccc aaaacagccg ccatcatcca 3129661 aagcatcccg gacaaaagcg tccctaaacc aaatgagagg gcgatcccaa tagaaaccaa 3129721 gagcagcttc aaggcgcgct ttttgtacga ttcaccgccc gcatataaat aaacaaagcc 3129781 tccgatactt gcaattaatc cgtaatccgt gtgacctgcc aatgcaccga ccagcacagg 3129841 aaaccctgaa gcgaaacctg atccgatagc ctttttccaa ggaaatggat ttgcatgaat 3129901 gcgaaaggca tccttcacga taggcatgat tctttgattg ttcgcagcag ttttgttcat 3129961 ttgacaaaat ccttttcaat gaatgtgtag aacttttcca gtttcttcgc tttagtatgc 3130021 ccaaaaacgc ggttagcttc tcaattggtg cgcacgataa aaaaacagag acttataccg 3130081 tctctgcttc attacatcag tttattataa aagcggcacc tgtcaggact gttttgtcct 3130141 tctgccttcc ttcaagagca ggtgaataaa aaataaagga taaatcaata gatacccatt 3130201 aaacagccac cacacaagat caaagtcact gctgaatgtc cagaatgata gcgcctgcag 3130261 acctgaacaa caggtcagca caagagaaat cagcgccatc agcttccagt cagcacgatt 3130321 cacccgctgt aggtacaagc tgtacaaccc tgtgacagaa atcaggatat ccagcggaaa 3130381 aaaagaccag ttccaagcga tcataaacgg atggtcatga tgtttaaaag cccagctttc 3130441 cggtatgagc gaaaatccgg ctgacagcca gtacaagata aaaccgatat cagtcacgag 3130501 aaaaaacagc ttcatatatc tcatttgtac tgcccgcttt tatgtaccgg ctcagacacc 3130561 gcaacatgct cgatcaggtt taaagacaca acaccggcaa taatcaatcc aattgaaatg 3130621 actttcatga cactcacatg ttcttgaaaa aacaaaaaac caacgactgt aatcaagaca 3130681 attcccatcc ctgaccatac agcataagca actgatacat caatggattt aagcgtaagc 3130741 gtcagaaaga aaagactccc tccataaaag aaaatcaaca gcaaactggg aataagcttt 3130801 gtaaaaccag acgatagctt catgctgaca gttcccgcaa cctcaaacaa aatcgccaag 3130861 catagaaaca cccaattcat gtggcatcag cctcctcatc agctgttata ccgttaaaca 3130921 aaacatctac aattgattca agtacctctc ctgtcgtgaa ctgatgtttc agcggatatt 3130981 cagggtcata cacttgattg atgctcccta tatacatgtg aacaaacagg tccggattga 3131041 tgtttctgat tctcttttgc tgtttgcact catttaataa tgctaggaca atcgcccatt 3131101 cttccttaat aaacgcgtct aatgtaagcc acgcatcgta atggtatttc tttagttcat 3131161 ttaataatcc catgttcagc agttccatcc cctgcggaag gctgatcagc atttgtttca 3131221 ccttttcgag cacatttaaa ctttcatttt catagatgtc tctttctatt tgcttcattt 3131281 cagctataaa ttgttcgaca accgcctcaa caagctgatc tttagatgaa taatatgcat 3131341 agagcgtccg cttgctcgtt cccagcgctg ccgccaaatc attcatcgta aatgaaaatc 3131401 ctttctgctt gatcagccgg aaggtttccg ccagaattct tttatccata ttaatccccc 3131461 gctttcggta ccaagaaaac tatttcggta ccaatattat acggcagaaa tttatggaaa 3131521 tcaacaatat ataaaaaaac ctctcctatt gggagaggtt taaaagacac tgcggaccaa 3131581 accgccgtcc gcccgaagtg ccgcgccatt gatcgcagag gaaagcggac tgcttaaaaa 3131641 tgtaacgaag tgggcgattt cttccggacg gatcagtctt tgaataatag atgtcggccg 3131701 gttttctttc ataaaacgtg cctcagcttc ttgaacagtc aggttttcac caggatacag 3131761 cgagttcagc atggtttcca caccctctgt taaggtagag cccggcatga cggtgttgac 3131821 tgtgacattc gtgccggttg ccagctccgc caaactgcgg gaaatggaca gctgcatcgt 3131881 ttttgtcgca ctgtaatggg ccatttcctg tgacggcata atcgccgctt cactggcaat 3131941 gaaaatcaca cgcccttctt ttttctctat catgttatgc aaatacctgc gtgtcagcct 3132001 tacaccgctc ataatattca cttcaaaaaa acgaaaccat tcatcgtcgg gaatatcaaa 3132061 gtactccgcc ggttcaaaaa tccctaaatt gttgaccaaa atatcaacct ctggatatgc 3132121 ctgaaacagc tcattgcagc cttcttctgt tcccaaatca aatgcagccg gataaagaac 3132181 cgcttcagca tgttgtgttt tcagttcatc tatcgtttga ttcactttct cttcccggcg 3132241 tccgttaatg atcactgccg caccttcttc agctaacgaa gaggcaatag cttttccgat 3132301 ccctgatgtc gaaccggtca ccagtgcggt ttttccttgt aaattcagct tcattattca 3132361 tccctccgtt tttgattcct cttatttatt gacagaaatc tgattggtga aacatctgct 3132421 ctgcaatcag tatgaaacag ctgggattga aatggaagta cgcacttttt ggtgcctgtg 3132481 gtttggagaa aaaataaagc agaacctctt aagaggttct gctttattgt cagtatgtat 3132541 ggagacggtg ggagtcgaac ccacgtccag aaacatcgat tacttaagcg tctacgagcg 3132601 tagcctgcat atttatggtt tcactcatct tcttgcctgc gggcgggcct tccgagagct 3132661 agtctgttca tctcttctta cgttctcaga cgggaacgca agcgtagcct acttggatgt 3132721 gctcttcaca gacacatagg caatgtcagg aagagctcgc tgcgcttatt aggcagctaa 3132781 tgctacgttt tggttaaaac tgttagtttt gccagttata tttaagtgcg tgtttacgag 3132841 atcgcctctc ggctcgcagc tcaagctcga tccatccctg tcgaatccgt aacgtcccct 3132901 tggtataagg gaaatacggg agaaaatatc aagctctcac tcaaactggc tatagtctta 3132961 ttataacatg atcacggctc ttttcaattg tcaaatcctt caaatgaatg gcgtcgtgat 3133021 ctgatcgtga acacagtata gcacaggcct gattttcgaa tcaagcacta tgcctttaga 3133081 agcctttttg actgtctctg aacgctcttt cgatttcccg cttcgcgtcc ttgcgcttca 3133141 gatcttcccg tttgtcatag ttcttcttcc cttttccaag gccgagaagc actttggcaa 3133201 agccgttttt taaatacagc ttcagcggaa cgagagaata gcctttttcc tttgttaacc 3133261 cgatcagctt attaatctcc ttgcggtgca ttaacagctt tcttgtccgg agcggatcgt 3133321 ggttatagcg gtttccctgc tcatatgggc tgacgtgcat attgtggaga aacacttctc 3133381 cccgttcgat tttggcgaag gaatccttaa ggtttacgcg gccggcgcga atcgatttga 3133441 tttcggttcc ttgcagaacg atgcctgttt cataggtttc ttctataaaa taatcgtggt 3133501 tggctttctt attttgagat aatacttttc ctgacccttt tggcatgcca gaacctcctc 3133561 tctctaagga aaaactgtcc accttttgcg atacgctcta ttttaccaaa tgtcacgtac 3133621 cgctacaatg aaaagctgtt tccgaaagaa agcaaataga gcgctgcggc cctatttgct 3133681 ggttgagctg ctatttcttc tttttccgtt tctgtttcgg agcattctgg aagccgcgtt 3133741 ttttcttttt cttcttcggc ttagtgaacc actccccttt ttcctcagac ggagctggag 3133801 aaacaggtgt attggtgctt tgaacacgtt ttctggcagg ctttccgcgt tttctgctcc 3133861 ggctgctgtc caattctctc ggacgccgcg gagtgccttt catgccgaca atttcaaagt 3133921 cgatattgcg ctcatcttta ttgacatcga caaccttgac tgtgatttca tccccgatgc 3133981 ggaagacgtt gcctgtccgc tcgccaatca ttgcgaaatg ctgttcgtca aagcggtagt 3134041 agtcatctgt cataaagctg acatggacga gtccttcaat tgtattcggc agctcgacga 3134101 acattccgaa gtttgtcaca gagctgatca tgccgtcaaa ctcttcaccg attttatcaa 3134161 gcatgtattc cgcttttttc agatcatccg tctcacgctc ggcgtcaact gcacggcgct 3134221 ccatagatga tgtatgttcg gcgatatccg gcaggcgttc agcccacttt tcctgtgtcg 3134281 cttcatcgac cttgccgttg atcaaatacg ttcggatcag acggtgaacg attaagtccg 3134341 ggtaacggcg gatcggtgat gtgaaatgcg tatagaattc cgttgacaga ccgaagtgcc 3134401 ccaagctttg cgggtcgtat ttcgcctgtt tcatcgaacg gagcataaca gtagatataa 3134461 ccgtttcctc tggtctgtca cgcacagcgt ccagaatgct ttgcagcgcg cgcggatgaa 3134521 tattccccgc cgttcctttc accacatagc caaatgtcgt cacaaattct aaaaactttt 3134581 gcagcttttc agcattcggc tcttcgtgaa tccggtatat aaacgggaca ttcatccaat 3134641 ggaaatgctc cgcaactgtt tcgtttgcta caagcataaa ttcttcaatc agcttctcgg 3134701 cgacagagcg ttctctgatc acaacgtctt taaccgctcc ttcgtcatca acaagcacct 3134761 ttgcttcttt gaaatcaaag tcaacggcgc cgcggtccat ccgcttatcg cgcagaattt 3134821 gagccagacg ctccatgtct ttgaacatcg gaacaagagg ctcgtatttt tgtttcagct 3134881 cttcatcatc atcaacaaga attttattca catctgaata tgtcattctt tccgttgttt 3134941 tgatgacact ttggaagatc tcgtgctctg tcacctgtcc ctgactgtta attgtcattt 3135001 cacaagaaag cgtcaggcgg tcaacctttg gatttaagga gcagatgccg tttgacaatc 3135061 tgtgcggaat catcgggatg acacggtcaa ccagatacac acttgtccct ctttcaagcg 3135121 cttctttgtc aatcggcgag ttttcggtta cgtaatggct gacatcagct atgtgaacgc 3135181 caagcttgta gcttccatca tcaagcttcg tcacggtaac tgcatcatcc aaatccttcg 3135241 catccgcacc atcaatggtg acaatcacct ggtcacggag atcacggcgg tctttcagat 3135301 ctttttcatc aatcgtgtca ggcgtacttg atgcctgttc catcgcgtca gctggaaatt 3135361 ctcccggcag gccgtgctta tgaatgaccg ataaaatatc aatgcccggg tcgtttttgt 3135421 ggccgagaat ggtttcaacc tcaccctctg cgttcatgcg gccttcagga tagctcgtca 3135481 gcttgacaac aaccttatgc ccttccgcag ctccattttt cccatttttc ggaatgaaga 3135541 tgtcactcgt gatttttttg tcgtccggaa tgacaaagcc gaagtttctc gtttctgtat 3135601 acgtgccgac aacccgctga atcgctcttt ctaaaatccg tatgacggtt ccttcctgcc 3135661 tggagccgct tgattgtgag ttcagacgca ccatgacgat atcgccgttc attgccgtat 3135721 ttagctcatt aggcggaata aacacatcac ttaacgacgt atcctcaggc agcaaaaagg 3135781 cgaatccttt cgcatgggct gaaatctttc cttttattaa attcatcttc tccggaatgc 3135841 cgtagcggtc gcttctcgtc cgtacgataa gccctttttc ttccaaggcg actaacgctt 3135901 tgacgagctc tttaaactcc tcggcttccg taatatttaa catctcctca agttcctgaa 3135961 cggtcagagg tttgtacgcc tcttccttca taaacgagag aagcttttcc ataaatgctt 3136021 ctttttccat tatccgacct cctgttgatt accaatcgag cttctctaaa aattcataca 3136081 catcctgatg gacgaggtca cgttctttgt cgagtgtaat gacatgccct gattcctcgt 3136141 accatttcag ctgtttatca tcagtttcca cttcgttgta aataatattg gcgctttcgg 3136201 tattaatcat gtggtcatga cgggcctgca ccacaaatgt cggtgaataa atcatatcga 3136261 cattattccg cacatcagca attaagtctt gcagcgcctt gagggtattc atcggcgttt 3136321 tttcgaattc tttcatttcc tcttcaattt gctccgggct tttcccctca aactttttgt 3136381 aattgcgagc gtatgaaaga acgccttgat acatgacctc ttcactctta atatgcatcg 3136441 gtgcgcacat tgggacaatt ccctttatgg gtacagtgta acccaatttc agcgaaaaaa 3136501 ccccgccaag cgacagtccg caggcagcaa tgctctcata accttcagat tttaaatatt 3136561 catagccatc cattacgttt ttccaccagt cttcgggccc cgtatgtaca agttcttcag 3136621 gcgggacgcc atgtccttca tattgaggcg cgtggcacgt atagccgcgt tcattcaaat 3136681 atcgtcccag catccttaca tccgctgtat ttcctgtaaa gccatgcagc aaaagcaccg 3136741 ctttgtctcc gcctttaaat gtaaatggtt ttggtgtcac aactttcatg ctcatgtctc 3136801 cctttctatc tgcacgatca ttttagtttt ccacagttta atcagaaaaa aacgttttga 3136861 atatcatcca gaaacgtgaa aaaggcctga cttcacatca gaccttatac aaacattgcc 3136921 ctataggata taagcaagcg caatcgttaa cacgaaaaac aagactgcca gcactaccgt 3136981 aatgcggtgc aaaattaaat caagacctct tgctttttgt ttcccgaaga gctgctccgc 3137041 tccgcctgaa atcgcaccag ataatccggc acttttactg gattgaagca aaacgacaat 3137101 aataagtgca atgctgacga taaccaataa ggtaatcaaa actgcgtgca tcccatacac 3137161 ctccagactc actggctaca ttacttctat tttacatgaa aagggttggc atgtcacgct 3137221 gtatcagacg ccaaaaggcc ggataagacg ttttatcttg gttaccctat tcatatgaaa 3137281 aggtcaaagg agaaaagcga tgccgcttat cagcatagac agcaggaaac atctttttta 3137341 tgaagaatat ggacagggaa tccctatcat ttttatccac ccgccgggca tgggacgaaa 3137401 ggttttttat tatcagcgcc ttctatccaa gcatttcagg gtgatttttc cggatttaag 3137461 tggccacggt gatagtgatc acatcgatca gccagcgtct atttcctatt acgcaaacga 3137521 gatcgcgcaa ttcatggacg ctttgcacat tgataaagct gtgttattcg ggtattctgc 3137581 cggaggctta atcgcgcagc atatcggctt cacccgcccg gacaaagtgt cacaccttat 3137641 tctgtccggc gcctaccccg ctgttcataa cgtaatcggc cagaagctgc acaaactggg 3137701 aatgtatctg cttgaaaaaa accccggttt gctcatgaaa atcctcgctg gcagccacac 3137761 aaaagacaga cagcttcgca gcatattaac agaccatatg aaaaaagcag accaggccca 3137821 ttggcatcag tattatctgg attcgcttgg ctacaactgc attgaacagc tgccccgcct 3137881 agaaatgcca atgctgttta tgtatggcgg cctgcgggac tggaccttta caaacgcagg 3137941 ctattaccga agatcgtgca gacatgccga atttttcaga ttggaatatc agggacatca 3138001 attgccgaca aaacaatgga aaacgtgcaa tgagctggtg acagggtttg tgctgacaca 3138061 tcattcatag gaatagaaaa cgcttggctt ccttgcgttt tttgttactt tattgacttt 3138121 tgtcaacgaa atcatagtaa aaaagatcct caaatttcaa attaaaatag tgaagcattt 3138181 taccaatcac aagctgcccc ggccttcttt ctccattcag cacgcggctc agtgtggcgg 3138241 gtgagactcc gatttccagc gcaagctgat taagggaata atcgttatta accatatact 3138301 gcaagacata atcacgtcta atctgtatct tttctactgg cactttcctc accttccatt 3138361 cctgaaaaac ttttttctat acttttacat tacggcttat gttaactttt gtcaatacat 3138421 ttccagtcta cctattccct ttagtcaata aacatactaa aatatgagta acagtgaggg 3138481 acggggtgag atatatggaa agctttggcg aacaattacg ggcattgcgt gaagagagaa 3138541 agttaacagt caaccagctg gcgacttatt caggcgtaag cgcggccggc atctccagaa 3138601 tcgaaaacgg aaaacggggc gttcccaaac ctgccaccat caaaaaactg gcagaggcct 3138661 taaaaattcc ttatgagggg cttatgtaca aggctggtta catcgaagaa gtgcatgaag 3138721 ccagggcccc ttatgaaacg aagtgcaagc tgcttgaaaa agcggaggcc tatgacctga 3138781 aaaaccttgc gcttcttgag aacgaaaagt ggcaatatct caataaagaa gatttgctca 3138841 tgctggatca ttatttttcg tttatttcag atgaagcgaa aaaacggtct gctgatgact 3138901 gactcttgat agaaatgtga ggcgatagac catgtcaccg ttcggacagc aattacggga 3138961 gctgcgccgc gcccgcaaac tgacagtgaa tcagcttgcg gtgtactcag gcatcagctc 3139021 ggccaccatt tcaaaaattg aaaacggcaa acgcgggacg ccaaaacccg ccacgattaa 3139081 aaaactggca gccgtcctga aagtgccgta cgaaaaccta atggccgccg caggccatat 3139141 tcaggccttt cctgaagaaa tccgcgaagc atctgaaggc tatcaatccg tttatgaaat 3139201 ttaccagacg gctgtcacac gcggagcgga gcacctcccg attttcaata gtcaaaaatg 3139261 ggaacatctc tcaaagcagg atattgaaaa tctcagcaaa tacttcgatt ttttgtcttc 3139321 agaagcaaaa aaacgcgcct cttcctcata atcccctgtt tctctttcta tattttatca 3139381 atcacgcttg catgccctcc ctcgttattt gcgttataat agtgacagac gaggtgaaaa 3139441 gtatgaacca atcagaaatg tgtcctagat ttgaaaaagc agtcgacatc ttaagtaaac 3139501 gctgggtcgc tttaatcgta tttcagctct tgaacgggtc gcagcgattt agcgaaattg 3139561 aagcagcact tccaaatcta agcggcagag ttctgtcaga acggctgaaa gaacttgagc 3139621 ttgaaggagt agtgaagcgg gatgtcatcc ctgaaactcc ggttcgcatc gaatattcat 3139681 tgactgataa aggaaaggca ctagcaccca tattaggtga gatttctaaa tgggcgactg 3139741 aatggattga cccttccttt cttgactaat tgctaaaatg gttctgatct caaagacgag 3139801 aaaagaaccg ttttttattt tccaggtgaa aaaaagatat ctcagccgat atatagtaca 3139861 tccacacatt acgtttttaa aggagaccac tatatgcgac tgacgatttc ccgcaaattc 3139921 agcctggtat ttttgacact gatcctgatc aatttacttg taggcggaat aggcgttctt 3139981 aatatgcagc atatcattca aaaaacagat gaaatcaaca caaaatggat tgacggcatc 3140041 aaaggaatca cttcaattaa ttatgtaacc gagcacctgt cttctaaaga aaaggacttt 3140101 ctgatttata cagacaaaag taaaatggat acacttgatc aagaaatgaa tcaaatcatg 3140161 gaagacatta accaaaagct cgataactac gaaaaaacga tctccactga taaagagcag 3140221 aaactgttcg agcagcttca aactaaagtg aatacctata tggatattca tgcgcaaatt 3140281 atcgaaagcg gccgcacgaa tgacatggac aaagcaagag gtttattggt tcagactgag 3140341 gccagctttg aggatatgaa aaaaacaatc actcagcttg ttgacttaaa tcaagaaggc 3140401 agcaacacag cggtaaaaga aacgaaggcc gtctatcata aagggctcat ttacactgct 3140461 ttgcttgtgg cagcatcaat cctcatcagc attttcatct ggctttatat cacgcgaaac 3140521 attgtaaagc ctatcattcg catgaaggaa tctgccaatc atattgccga aggcgatttg 3140581 tcgaacgata tggaggccct caactcaaaa gacgagctgg gtgatctgaa tgaagcgctg 3140641 caaaaaatgg tagggaatct gagagatatt gtcggatatt ctaaagacat atcaagccgg 3140701 gttctttctt cttcacaggt gcttgcaacc gcaacgaatg aaacaagatc cggcagcaaa 3140761 catattaccg agacgatgaa cgaaatggct gagggctctg aacagcaggc ccaagacgcg 3140821 gtgacgattg ccgaatcgat gaatgagttt accgaaagca ttgataaagc ctataatcac 3140881 ggcatcacaa tcagcgatac gtctcaaaac gttctcgaac tcgcggtaag cgggaacgaa 3140941 aatatggcta cgtcattaca gcaaatgaaa accatccatc atattgttga agaagccgtg 3141001 cataaagtga gatcactgga acagcattct caggatatta acaagctcgt tcaggtcatc 3141061 aacgggattg ccgagcagac gaatttgctg tcccttaacg ccgcgattga agctgcccgc 3141121 gctggagaaa gcggcaaagg cttcgccgtt gtggcagagg aggtcagaaa gctggctgac 3141181 ggcgtttctg attccgtgca ggacattacc cggattgtaa acgggacaca gcaggagatc 3141241 cacactgtca ttacgtactt ggaaagcagc tttacagaag tcgaaaaagg aacggaaaac 3141301 ctgacagaca ccggacaggc tatgcagcat atcaaacaat ccgtcaccca tgttgcagac 3141361 agcattaagg aagtaacgga tggcttgaag cagttaacaa accaatcgat taccatcaat 3141421 caatcgattg aaaatatcgc ttctgtatcc gaagagtctg ccgccggcat tgaagaaaca 3141481 ttttcaatta ccgagcaatc cgcccattcg atggatcaag tgcttctaaa tgctgaagag 3141541 cttgagcagc tggccaatga gcttaatgag aagatgggtc agtttacgat ttaaagagaa 3141601 aaaagaggct ggactccagc ctctttttct attctatgca gctgattgaa catgtttcgc 3141661 cccggttctt tttttcttca ccggacttaa tgcccgctcc agccaagcca tgagcaaatc 3141721 cgcccctacc gccatcaccg cagttggtat cgctccggct agaataatcg cagttccgtt 3141781 tgttgcgttt gagccgcgta cgatcatgtc cccaaggcct ccggcaccga caaatgtgcc 3141841 gatcgctgta attccgatgg caatgacgag agccgtgcga aggcccgcca taatgacaga 3141901 aagtgcgagc gggagctcaa ccattctgag cacttggaat ttcgtcatgc ccattgcttt 3141961 tccagattct aagtaggcat gttcaatact gataatgcct gtgtacgtgt ttcgaataat 3142021 cggcagcagg gaatacagaa ataatgatag aatcacggta tttgcgccga gccccataac 3142081 aagcattaag acggccagca tagcgagcgc cgggattgtt tgaataacgt ttgttacggc 3142141 aaacacccag gctgacaaac ggcgaaaatg cgcgatgagg attccggccg gaaccccgac 3142201 gacagcggca aataaaacgc cgtaagccga catgagaaag tggcggccga attcatccat 3142261 gacgtaactg ccattctgcg cgtaatacgt cattaactgt tcaagcacgt tcattgacct 3142321 cttccccctt tcacgattcg aaatagcgat gtttttctaa atattccttg gcaacgacag 3142381 acggttcttt gagattgccg tcgacttcat agttaagctc ctgcatcgtg gctgtgtcga 3142441 tttttccgag cattttcttg atgatgcctt caagttcagg atgttctttg agcacctttt 3142501 ccggaacaac cggagagcag tcgtacggcg ggaaaaattg tttatcatcc tttagcattt 3142561 tgagaccata ggacttgatt cttccatcgg ttgaatacgc aagcacaatg tccatttttc 3142621 cgcttttcac cgcgtcgtac acaaggccga tctgcatcgg atacgtgccg ccgaatgtca 3142681 tgccgtaggt tttcgtaaaa tcctgatagc cgtttccttt gagcttcatc caatagttat 3142741 caacgcccag ctttaattgc ggcgcccatt ttttaacgtc tgatacggtc tctaaatggt 3142801 attggtcggc cagctccttg ctgactgtaa aggcatatgt attatcaaac ccgtaggagt 3142861 cataccactt taaatcatat ctttttttaa actcccgctg agtaagcgcc agcgctttgt 3142921 ccggatcttt ttcaggttcc attctcaacg tgcctgtcag cgcgtctccc gtatatcttg 3142981 tggccgcaat gtcgatttcc ccgttcatta aagcctgctg ctgcaccgcg ttggagccaa 3143041 gatttttaat cgttgttgtt ttgagatcag tatggtgttc gatcaactgg ccaagcatgc 3143101 tggcgatgat ttctgattcg ctcatgcttt gcgcgccgat tttaatggtc tggtctgcag 3143161 cagcgctgag accaggaagc gaacagccgc tcagcgtcag cgttgccgca agtgctaaac 3143221 ctatcattaa tttgagatat tttcttttca tgagccgcct ccttatgaca attccttcaa 3143281 tctctgcatg ccggcaggtg tcagttttcg ttcagcaact gccagcacat aatcaatcac 3143341 aattgccaat atcgtgacag gtaccgcgcc cccgatgata tattccggct gatataaatt 3143401 cagtccgata aaaatgtaat cacccaatcc gccgcctccg ataaaggaag caagcgtggc 3143461 ccagccgatt aagtaaatcg tcgatgttct gattcccgcc atgatcactg gtgcggcaag 3143521 cggcagctcc accaagcgga cttgttcagc cggcgtcatt cctattcctt taccagactc 3143581 gagcagattt ttgttgacgc cgcgaatgcc ggtatacgtg ttgcgaagaa tcggcaatac 3143641 ggaatagaaa aacaaagcca caatggccgg aaccttccct acaccaagga gcgggataaa 3143701 aaaagcgagg atggccagac tcggcagcgt ctgaatgata ttgacaatgc cgataatggt 3143761 gccggctcct tttttcattc tggtaagcac aaccccgagg gggacggcaa ccagcacacc 3143821 taagatcaca gcaatgagcg atatcgtaat atgctcgtat gttttataaa gaagctctcc 3143881 cccattggtt tgcaaaaatt gaacaatatg atgcatgact tatcgcccct ccctatgaca 3143941 atgctgcgag ctgcttttct tctccccaga gggagtcata cacgatgtcg accagacttg 3144001 ccctcgtcac aattccgatc aggcgtcggt cttcatccac aacgggaaca tatttgacac 3144061 cccgttttaa aattttgcgg accgtgtcgc gcagcagtgt gccgcccagt actgtgtata 3144121 tatcttcatg taaaacttca ctgacgagat tggccttttt ccggcattga tcaatgattt 3144181 caacatcgac atagccttgc agaacgcgct cgtcattgac gaccagcaat gaatcgaccc 3144241 gttcctgcct catcagctga atggcctcag aaagcgtttt atccgcggtg atcgttacag 3144301 gctgtgtgtt cataatctgg tcaacccgtt caacatccgg gctggatgac tgaatcagcc 3144361 gctccttgcc gataaattcc tcaacaaatt cgtctgccgg atttcttaaa atgtcatcgg 3144421 gcgttccaac ttgaacgatt tctcccgctt ttaaaatcac aatccggtct gccagcttaa 3144481 tcgcttcatc catatcgtgg gtaacaaata cgatggtttt atgtaaggtt ttttgcagtt 3144541 ttttaaattc ttcctggagg gaatccctcg taatcgggtc gagtgcccca aacggttcat 3144601 ccattaagat aagcggcggc tccgcggcaa gtgcccgtaa tacaccaatt cgctgctgct 3144661 gccccccgct taattcatga gggtaacggt ctacatattc tggccccata tcgaccaatt 3144721 ttaaaagctc acgcgcccgc tctttccgct gctgctccgg ccatttcagc agttttggga 3144781 cgagtgagat attctgctga atggtcatat ggggaaacag gccgatctgc tgaatcacat 3144841 agccaatttt gcgcctgagc tctacaggat cctggtccat gatgttttcg ccgtcaatga 3144901 aaatcttccc ggcggaaggc tcaattaatc ggttaatcat tttcattgtt gtcgtttttc 3144961 cgcagccgct cggcccgata aagcagataa attcgccttt tgcaatctta agatttacgt 3145021 tgttcacggc ttttttgccg cccttgtatg ttttcgagac attttctaat gtcagcaaac 3145081 atcgcacctc caaaattaag tttattcaat ttgttcagtt taaatttaat ttttcagaca 3145141 attgaatgct tcccattata gaataaagtt tataaaataa aaagtttaca atttgttcat 3145201 attatttata aagtatgtgt aaacgctgat ttacccgcat tgacgtgtgt tgatctcctt 3145261 attgctccaa tttcctgcca aattctcttt tgacagcatt ttcgccgtat caaaaatgtg 3145321 gtatattgac atcggaattg ttagctgaaa ggatgaaacc gttggagaaa gatccgttaa 3145381 cgatcattga acaagccgag gaccatttta tagaaagaat cgcggaaaac atgcatgcat 3145441 ttggaatgcc ctctaccgtc ggacgagtgc tgggcattat ttatatgaat cgaaaaccga 3145501 tgacgcttac ggaattatct gaggccaccg gcatgagtaa aacacgtatg agccaggtag 3145561 tgcgggaaat gcttgatgcc aacattgccg agaaggtatt cgaaaaaggc gtgcgaaaag 3145621 atttatatga ggttgagcag gactactatc aaacatttat cacgctgttt tcagccacct 3145681 ggagcaaagt cgtcagcaaa aacaaaatga tgcataaaaa actcaatcgg gagctgctta 3145741 gcgtgttgga tgaagagctt actcctgaag cggaagaaaa agtgaatgag ctgctgaagg 3145801 aattaaagga atggctcgat tattataatt ggctcagccg tttgattgag ttttttgaga 3145861 gcgaagacat ttttaaatat gtgccgaagc cgtaaaaagt tcccaaattc aattctggga 3145921 acttttttaa gtccaatcca aatggttgaa tatcaaactt caagaaaaca aacaaaataa 3145981 tgcataattt acattaattt attaattatc cattttttgt tgattattct gactagctat 3146041 tatataatct ttttgaaatg attatattag cttagaggag gtaatctaca tcaaaaaaaa 3146101 gggaattatt actgtaatga ctatatgttt cctattattt tcttcttatt actttagcaa 3146161 tatttcacct cagaatccac tgttcaaaaa aaattttttg caacaattgt ctccccaagg 3146221 ctttggcttt tatagtaaaa gccctacaga agaaaacatt tcatttcaca caaaagaaaa 3146281 tttaaagtta cctaatgcac ttcccaataa tttttttggg ataaaaagag aaggaagagt 3146341 tcaggcaata gaattaggca aaattgtaga gaatatcgat ccaaagaatt ggaaaacttg 3146401 tgaaaacaac aactcctgca caaatttaga gaaacaaata aagcctatta aggttataaa 3146461 aaatgaagat tatatacatc ttagcaaagg agaataccta atatatcgcc aaaaaccact 3146521 ctcatggtat tggatagact ttaagcaaac tacctctttt gaaagaaagg tgctaaaaat 3146581 aaaaatagta tgaagatatt aaatagttta gaaggttata ttgacaccta taatccatgg 3146641 aaaaatacat atgcactttt tagaagttta cttggtttct caacattact agtactatta 3146701 ttcaatagta ctgatatttt atttagttat agtgcaaata atgtcacatg tgaaaatgtc 3146761 tatatcccta ccgctttttg ttttgctaaa gaatatagta tcaattttga gattataaga 3146821 tacttaatga tttttatatt aaccttagtg gttatagggt ggagacctag atttaccggt 3146881 ttatttcact ggtatatttg ctatagtatt caaacttcag ctttaactat cgatggtgga 3146941 gagcaaattg caactgttct ttcttttctt atattacctg ttacattatt agattcaagg 3147001 cgaaatcatt ggaatataaa gaaaaacaat aatgaatctt tcacaaagaa gacagtattg 3147061 ttttatataa tgacaataat taaaattcaa gtttttatca tttatttaaa cgcagcttta 3147121 gagcgattga aaaataaaga gtgggcagaa ggaacagcaa tttactattt cttttctgat 3147181 ccggtgtttg gattacctga atatcaactt aacttaatga atccactact tgaaagcaat 3147241 tttattgttg tcatcacttg gttagtaact atttttgagt tgttcttagc agcaagcata 3147301 atttcaaata tcagaataaa gagaattgcc cttgttttgg gaatattatt tcatattggg 3147361 ataatattca gcattggtat tgtaagtttt ggcttgatca tgatatcagc attaattata 3147421 tatctgcatc ctgtacaaca aaatatcact atgaattggt gttctccttt atttaaatat 3147481 atatatgtaa aaggaaagag aaatttcaaa agaataggag gtgaatcagt caagtttctt 3147541 acaaaattgt ttcatagcta acatttagat aatggagaaa taacttaatg gaggtataat 3147601 aatttgaaaa gtaaattact taggctattg attgtttcca tggtaacgat attggttttt 3147661 tcattagtag gactctctaa ggagtcaagt acatctgcta aagaaaacca tacattttct 3147721 ggagaagatt actttagagg acttttattt ggacaagggg aagttggtaa attaatttca 3147781 aacgatttgg accctaaact cgtaaaagag gcaaatagta cagaaggtaa aaagttagta 3147841 aatgatgtag tcaaatttat aaaaaaagat caaccacaat atatggatga attgaaacaa 3147901 tcgattgaca gcaaagaccc taaaaaactc attgaaaata tgaccaaagc agaccaactt 3147961 atccaaaaat atgctaagaa aaatgaaaac gtaaaatact cttctaataa agttactcca 3148021 tcttgtgggc tttatgccgt ctgtgtagca gctggatatt tatatgttgt gggcgttaac 3148081 gcagttgcat tacaaacggc tgccgcagta acaactgcag tgtggaaata cgttgccaaa 3148141 tattcctctt cagcttctaa taattctgat ttagaagcgg ctgctgcaaa aaccctaaaa 3148201 ttgattcatc aataatccat tataattgag tgtcttgcgg attgctccgc aagacacttt 3148261 ttcaacgtga accgtttaat tttttgtaat aatgatatga agctagtgtt gaaataacta 3148321 atgctagaag aactagcaca atcataataa gaattatata ttctcctgta aaaaatgaaa 3148381 gaacagctat tataaaacca cacactacaa gtactttaga ggcaaagcga tttcccagtt 3148441 tccaaacagt ctcatctttt aatgtccaag gtgtcctcaa tccaataaga tggttttgtt 3148501 ctgctagctg catagaattt ccaccaataa ttaaaaagat accaacacca agccctatta 3148561 ttaaatcaat attcacttcg tatcctaaac ttatcaatag agttgagagt tgtaaaatat 3148621 ataaaaggat taacatatta ttagaagcta ggaaaagcaa tgctttattt ttttgtgtag 3148681 acttaatagt taacatataa aaagtaagat aataaataag cataacaaca ggtataataa 3148741 atattgttaa aggtttagat acaattgcag ccggtttatt tcctgaccat tgtatcggta 3148801 tttcttctgg aaggtattga tataatataa ttgaagtcaa gaaactcaaa catacaataa 3148861 ttatggaaat tatatttttc ttcataaatc gttatcccct ttatttataa agttaagcat 3148921 ccaatttatt gagtcttgaa gtactgttgt atttagagag taataaataa attgtccttt 3148981 gcgatggtca cttatgactt ccgcttgctt taaaatattc aagtggtgcg aaatactcgg 3149041 tttgctgata ttaaaatgct cagcaatatc tcccgcagtc atatcccctc cttttaacaa 3149101 atccaaaatt tttctccttg ttggatctga tatagctttg aaaacattat tcatagcgtt 3149161 ttctccttta caaaaaaaca tttagacatt tagatatttg tataaatgta ttattttcat 3149221 tataacttga atttttttaa aaacaaccct caaattggtt ataatatctg atttttgtat 3149281 tttttcaaat actcggataa tcccaacgct ggaaaatatg tttaacagat actaacacat 3149341 gttgtttatt taaaaaaacc acctctgttg tatttaaata gaggtggttt ttctatcagc 3149401 tataataaaa tttccttttt tctttttaat cgggcttaat gctcgttcaa gccagcccat 3149461 gaccaaatcg gcaatcaccg ccatcagagc tgtggggatc gctcccgcta atataatcgc 3149521 ggttccgttt gtggcgtttg atcctctgac gatgatgtcc ccgagaccgc cagcaccgac 3149581 aaatgtcccg atggccgtaa tgccgatcgc aatgacaagc gcggtgcgca ggccggccat 3149641 tatgacagaa agcgcaagcg gaagctcgac catccgcagc acttgaaatt ttgtcatccc 3149701 cattgctttt cccgattcaa gataggcgtg ctcaatactg ataatccctg tatacgtatt 3149761 tctgataatc ggcagaagag aatacagaaa taatgacaat atcaccgtat tagcgcccag 3149821 ccccatgaca agcatcagca cggcgagcat ggcgagagcc gggatggtct gaatgacatt 3149881 cgtgaccgca aaaacccatc cgcttaatct tctgtatctg gctatcagga tgccgagcgg 3149941 aattccaaca atggcggcaa ataaaacgcc atacaccgac atcagaaaat ggcggtaaaa 3150001 ttcctgcagc acgtaaccgc cgttttgcga atagtatgtg ccaagctgct gtagtacttc 3150061 catatgatcc acctcttttc ttagtcaaaa taatgatgtt tctctaaaaa ttcctttgct 3150121 acgacagacg gctccttcag cttgccatcc acctcataat taagttcctg catcgtttcc 3150181 gtgtcgattt gcccaatcag cttattgatc acaccttcaa gttccggatg ctccttaagc 3150241 accttttccg gaatcaccgg tgaacagtca tacggcggaa agaaacgctt atcgtctttt 3150301 aagattttca gatcatatgc tttaatccgt ccatccgttg aataagccaa aaccgcatcc 3150361 attttcccgt ttttgactgc gtcatagact agcccgatct gcattggata agttgtgccg 3150421 aactcaaagc catatgtgct gacaaagcct ttatacccgt cgccttttcg tttcagccaa 3150481 gcattgtcga cgcctaattt atattgggaa gcatttttct tcaggtcaga cacggtgtta 3150541 atatgctcct tttccgcaaa cttttttgtt acggtgaagg catatgtgtt atcaaagccg 3150601 taggaatcaa accatttata agaaaagcgc ttttgaaact cgttctgcac aatgttcagc 3150661 gcttttttcg gatctttctc cgcttccttg ccgagggtgc ttgttaaatc tgttccggaa 3150721 tagcgcgtgg ctgaaatatc aatgtcaccg cccagcatcg cttggtgctg aacatagttt 3150781 gagccgaggt ttttcactaa agcagtattc aaatctgtat catgttcaat aagctgcgcg 3150841 atcatattcg ctacaatttc tgattctgtc atgctctgcg ccccgatttt gatcgtatcg 3150901 tcagaagcgc cgcctagacc cggcagagag cagccgccta gcagcatgac aaagacgaga 3150961 gcaaacgcgc caagccattt gatttttgtc attttcaaca gtgccaactc cttacgatac 3151021 ttccttcatc ccttgcaagc ctttcggcgt cacctttcgt tctgtcacag ccagaacata 3151081 atcaataata attgccagaa ttgtgacagg cacggcaccg ccaatgatat attcaggctg 3151141 gtataggttc agtccgataa aaatatagtc cccgaggccg cctcccccga taaacgacgc 3151201 aagtgtcgcc cagccaatta ggtagatcgt tgatgtgcgg atccccgcca tgatgatggg 3151261 aatcgccagc gggatttcaa cgagccgaat ctgctcccag ccggtcatgc caattccttt 3151321 ccccgattcc aggaggtttt tatttacacc tttaatgccg gtatacgtat tgcgcaggat 3151381 cggcagtacc gaatagaaaa ataaagcgac aatcgcaggc acttttccta cgccgagaag 3151441 cggaataaaa aaggctaaaa tcgccagact cggcagggtt tgcacaatgt ttacgaaacc 3151501 gataaccgca cctgcgcctt ttttcattct ggtaagagca acgccgagcg gcactgcaac 3151561 gataatgccc aatacaacgg ctatgagtga aatatataaa tgctctcctg ttttatacag 3151621 cagctctccg ccgttcgttt gcaaaaaagt catcatttga ttcatcttaa aagagctcct 3151681 cccctggtca gatcgtcatg agctggtttt cctcgtcgcc ccaaatggaa tcgtatacga 3151741 tatcaacgag gctcgctctt gtcacaatcc ctgctaaatg gttctgttca tcgaccaccg 3151801 gaacatactt gatcccctgc ttcaaaattt ttcggactgt atcgcgaaga agcgcccctt 3151861 tttgaacggt atatatatct gaacggtata catcgccaac gatgctcgct tttttgcggt 3151921 tttgatcaat catttccaca tcaacatagc ccttcagcac gttttgccgg tccacaacga 3151981 gcagcgagtc aacacgtttt tctctcatca gctgaatcgc ctgagaaagc gttttgtccg 3152041 cagataccgt caccggcgtt ctgttcatca tttgctctac ccgctcgata tccggtcttg 3152101 actgaatcag gcgctctttc ccgataaatt cttcaacaaa ctcatttgcc gggtttcgaa 3152161 gaatctcatc aggtgtgccg acttgaacga tttctcccgc ttttaatatc acaatcctgt 3152221 cagcaagctt aatcgcttca tccatatcgt gggttacaaa cacaatcgtt ttgtttaagg 3152281 ttctctgcag ttttttgaat tcttcctgaa gggaatcacg cgtaatcgga tcaagcgctc 3152341 cgaacggttc atccattaaa atgagagggg gttccgctgc cagggcgcgc agcacgccga 3152401 ttctctgctg ctgtccgccg ctgagctcat gcggataacg gtctaaatac tctgggccca 3152461 tatccacaag ctttaacagc tcgcgcgccc gttctttccg tttttcctca ggccatttca 3152521 gcagctttgg tacgagtgag atgttctgct ggatggtcat atgggggaac aaaccaatct 3152581 gctgtatcac atagccgatt tttctcctca gctcaaccgg gtcctgttcc ataatatttt 3152641 ctccgtcgat aaagatcctt ccagacgatg gttctatcag tctgttgatc atcttcatcg 3152701 tcgtcgtttt tccgcagccg ctcgggccga taaaacagat aaattcacct tttgcaatat 3152761 ctaaatcaat gctgttcaca gcttttttgc cgcctttata tacttttgac acttgttcca 3152821 atttcagcaa tccgtgcacc tccgcaggtt tcctttaaat tttctgaaaa gtataatcct 3152881 tattatagtt tgaactttgt aaaataaaaa gtttacaatg tgttgaaatt atatgttatt 3152941 tatagattat ttattgttat gaccgagacg gaaagggtgt tcttacaatt actccggata 3153001 cctcccactt cctctgcatt cagctatttt caacaccagg aagaaatatg atatattgac 3153061 accatcaatt gccatttgaa gggatgatca gctgtgaaaa aaaccgctct cgacatcatt 3153121 gaacatgctg aagagcatct cattgagaag attgccgaaa atatgcatac gtttggaatg 3153181 ccttcaactg tcggacgtgt gctcggaatt atttatatga atcgaaaacc aatgacctta 3153241 agcgagctct ctgaggcaac gggcatgagc aaaacacgga tgagccaggt tgtccgggaa 3153301 atgatcgatg ccaatatcgc cgaaaaggtg tttgaaaaag gcgtacgaaa agacctttat 3153361 gacgtcgagc aggattatta tcaaaccttc atttctttat ttgcggcgaa ttggacaaag 3153421 gtcgtgagca aaaacaaagt gctgtataaa aaattaaacc gggagctgag tgatctttta 3153481 caaagggacg ggcttacccc ggaagcggaa gagaaagtca atcagctgct gaatgaatta 3153541 aaagaatggc ttcattacta tgattggctg agcaggttga ttgaattttt tgagagtgag 3153601 gaagtctttc ggtatgtgcc gaaaacaaaa gaatgcagct ctctaaaata agagagctgc 3153661 tttttgcatc atgaagttaa gaccggaaac atgcctttca gcccggcacc aatcatcccg 3153721 accgcaacca cggctaagat taatcccatc agtctggtaa tcacattcat ctcggttttt 3153781 ccgagtttgc tgctgataaa agcagaatag tggaaaaaga gaaaggtcag ggcaataacg 3153841 gcggctatgc cgatcatgac agccgcataa tgaccaatgc cgctatgtcc ggcggaaagg 3153901 ctcatcactg ttgcaatcgt tccgggccca gcaatgatcg gaatggataa aggtgtgact 3153961 gatatatccg ctttttcctt gctttcctta tgttcatcat ggtgaagaga ttgcacgtgc 3154021 gattctttcg cattcaatag attataggca atgccgaaaa tgaatatgcc gcccgccact 3154081 cggagcgcgt gaatgttgat atcaaacagt ttaaagataa gatgaccgaa aaccaaaaaa 3154141 gctgcgagaa taaaaaagga taaaatagct gccttccggg caatcgcttt tctttccgct 3154201 gcagtatagc cttctgtcag cgtcagaaat atcggtacgt ttccgatcgg attcgatact 3154261 gcgaataaag aaatgaagac gtgaacgata aatgagaaca tcatatacct ccttgttgat 3154321 agtctctgca caggaaatag aatgattctc caccctttta cccggaggcg atttcccggt 3154381 aaacctttat agcctgtcag aaacgcgcca tgctacaatg aagtgacaaa ttgaatagga 3154441 aggacgtata cagatgttca aaaaaattgc ggcagatgcc ttgggcttat ctgatatcgg 3154501 aaaaattatc gaacctcagg actatgacaa aacagacgca gatgactatg tcatgcatga 3154561 agataatgag aaaatttatt tcttgattaa aacaaaagca gacgagtatt gctttacgaa 3154621 cctggccctg atccatgtgg acggcgaacg cgccacttcc tcaaaacgaa cgttgaaacg 3154681 ctatccttat tcgcaatata aaatctctga cgtttttctt gaaactgccg gaaaagtgga 3154741 tttggatgtt gaaattaagt tcaagctggg cggtgaacaa ttcgacattg atgtccacaa 3154801 agaccagatt gaaaagttaa aagaccttta taaagcactg cttcgcatcg ctgaaacaac 3154861 ctatgaaaat gacattttaa tcaatcaagc ggagcaaagc ttagataaag cagtgacgat 3154921 tcttcaccat acccgccctg agcacgtcaa tattgaaacg caatacaaag agctgaccga 3154981 attcggattc acttggctga catccgttcg ctcgcagtat catattaagg attttgggga 3155041 tgtatttgag aaatatatta ataactagat aaaaaaagac acagctgcta tcgtgctcgt 3155101 gtcttttttt gtatgaatat tgattacttt acaacttttt tcttttataa taaaactatt 3155161 agtctatttt ccctatatta cagataaagg agttatttta tgtattgtcc tcaatgcggc 3155221 catcaaacag atggcggaaa tttttgtgag aaatgcggat caccgctccc cggtcaatca 3155281 ggccaccagc atgcagctca aactggagcc gctgcaaagc aagcagcaaa acagttcggt 3155341 tcatttgtct tatccgtcct gaaacgccct tatcaggaat gtaaagcaac aggcggagaa 3155401 cagctgatca gcgcaatcat tacgatggtt cttttcagtt tgctgacccc tttgatgttt 3155461 tatattcttt tttcagacgg tcccggaagc gtaagcttta cagcaatctt cttagagcca 3155521 accatttatt ttattttatt tctatttggc ctgcatgcat gcatcttttt cgccctgaaa 3155581 atcgcgggaa accaagtgtc tttcaaggat tcattctcaa gattcggagc atttcttatt 3155641 ccttttacgg ctattttgat tcttgccctt ttcttctttt tattacatac agacatttgc 3155701 tttaccatat tagccgttgg tttaatcggt gcattcttcg ccattcctcc tgcgatgctg 3155761 agcagttacc agcattcata taaagggaag gttgatttca tttactcaac gattgtgatt 3155821 tatctgatca tctgcgttac atttcagctt attatcgaac actatgtcaa agaaattttc 3155881 cgttatatgc tcttttaaaa acaaccccat cacctgctgg tgatggggtt gttttattga 3155941 atagacgtta agtaaattct tccgttcttc actacgccgg tgtaggtcca gttatatgtt 3156001 ctgagctttg gactgccgcc tgattttgtg atatagaatt cttcatacgt cttaatcgtg 3156061 atagccgacc cattttggct ccagcttttc acttcatagt tattaaagtc ttctgttgtc 3156121 ccctctttat ttaatttcga cacgagatgc tgctggtcgg aataaaggga actgcctttt 3156181 tcaaggctgt cttccatcag tgagaaatta ttttgattca cggcatctgc ctgactttgc 3156241 agataactgc ccataaataa tgtcacttgt tcatctgtaa catcgccgct tgcagagctt 3156301 tcactgcctt tgtttttcga gccagcccag gcggaagtgt atgtctctgg tttatcattt 3156361 ttgattttct ttatatttgt gcctgcagat tcgaatgttg attctgcatc ttcgaaaatc 3156421 cactttttct gttttttatc atatgaaaga agatattcat aactcggact gtcgtcagtc 3156481 atttcagact ttgtatagtc gttatacgaa gaagactggt gaagttcttt tcctgttacc 3156541 gatacctgcc acgttccgtc gtttttctga gagagggcaa atgtgtccag gtcaaaatca 3156601 gtttccaagt atctatcttt taagtatgaa tccgcgcttt tcatagaatc gacggtgtcc 3156661 ttcgtctccg ccttccaatt ggcacttgcc tctgtcatct gggctgtatt cccatcagat 3156721 agagctttgg agtattgttt tgttgttttg acaattgtgt tcataatctg ttcctgtgta 3156781 tcttgatcag gaattaacgt taactccatt tctttatcat cgatcggaac gccggcagtt 3156841 tttgtttttc cccacggaaa ttctgcctcg actgaagctg tcattgatcc atctgtcagc 3156901 agcggaccat atgttacgga tttgaacgga tctttatgaa ttgatttacc gttaatcagc 3156961 aaatctccct tcccgctctt gatgtcattc gctaagctga atgtcacatc gtctgcttcc 3157021 aatgagagat caacacgaaa gctgctatcg ccaatcgcct gaatgtcttc ctttttcaca 3157081 aggtcaacga catcgttttt cagtttggct gagactgtat attcgccggg aatgtacgga 3157141 ccaagggttt gtgcttgatc tgctttcttt acagatccgg cttcctcttt attgacatat 3157201 agatcggtat ttttataatt gctgctcact tcaaaataaa caggtgctac ctttaagtca 3157261 taatggtcaa ataccagcag gcttttcccg tctttttccg catatacgat atccttctgg 3157321 gctgtttcat cacgcagcga tgcaaaaagt tcatcttttt tgtctggatg atccttcaaa 3157381 tatgtaagaa acggttttac attattttta gtgagtttaa gattgtcatt taccggtgta 3157441 agcagagtcg cgatttggtc ctgatcccca tcatttacgg cctgttcaaa cttgtctact 3157501 aacctatcct ttgaagtaaa atacgctccg gttttatatg cggcgaataa tataacgcac 3157561 gccgcggcaa tgctgctcca taaaatgatg gttttcttag ggatcggttt tcgcggagcc 3157621 tgcctcgttt ctgcagtgct agctgtttct tgatttgcct gtttgctgcc ccctccgatc 3157681 ggggtgccgc attgtttaca aaacttggct ccttcattat tctgggagcc gcaattctta 3157741 caaaataaca tgactttcct cctattctac taatttgata acatttactg cttttcatat 3157801 tttataataa aacagaatga aattgggaac gaatgaaaaa attaaatgtc tatcagacta 3157861 aaaaggtgga atgaatatgc aaaagctcag gattgaatta ggagaagaaa caaatgacga 3157921 attatatgat ctattgctgc tcgccgatcc atcgaaagac attgtagatg aatatcttga 3157981 gaggggagaa tgttacacag cttgggccgg tgatgagctt gcaggggttt atgtattgct 3158041 aaaaacaagg ccgcaaacag ttgaaattgt aaatattgcg gtaaaagaat ctcttcagaa 3158101 gaaaggcttt ggcaaacagc ttgtacttga cgccatcgaa aaagcgaaga agctgggggc 3158161 ggacacgatt gaaatcggaa cggggaattc gagcattcat cagctttccc tctatcaaaa 3158221 atgcggattc cgcattcagg cgatcgacca cgatttcttt ctcagacatt atgatgagga 3158281 catttttgaa aacgggattc aatgccgcga tatggtaagg ctttatttgg atctctgaaa 3158341 gcataaaaaa gccgccgaga gaaaatcccg gcggtctttt tattacttgt ttaagttgta 3158401 gaaagagttg ataccgtggt attgagcagt ttcagccaac tgatcttcga tgcgaagaag 3158461 ctggttgtat ttcgcaacac ggtccgtacg agacggagca cctgttttga tttgtcctgc 3158521 gtttgttgcc acagcgatgt cagcgattgt gctgtcttca gtttcaccag aacggtgaga 3158581 gataacagct gtgtagcctg cgcgtttcgc catttcgatc gcatcgaatg tttcagtcaa 3158641 tgtaccgatt tggtttactt tgatcaggat agagttgcct acgccgtttt taataccttc 3158701 agaaagtttt ttcgtgtttg taacgaagag gtcgtcacca acaagctgaa cttttttgcc 3158761 aagacgctca gtaagaagct tgtggccttc ccagtcgttt tcgtcaagtc cgtcttcgat 3158821 cgagatgatt gggtatttag aaacaagctc ttcataccag tcaaccattt cagcagatgt 3158881 tttcacaacg ccttcgccag acagatggta tttgccgtct tctttgttgt agaactcaga 3158941 agatgcagca tccatagcaa gtttaacttc ttcgccaggt ttgaagccgg ctttttcgat 3159001 tgcttcaacg attgtttgaa gcgcttcttc gttagaacca aggtttggag cgaatccgcc 3159061 ttcgtcacct acagcagtgt ttaagccttt tgcgcttaat actgatttca ggctgtggaa 3159121 gatttgagcg cccatgcgaa gtgcttcacg gaagttagga gcacctacag gcatgatcat 3159181 gaattcttga atatccacgt tgttatcagc atgctctccg ccgtttacga tgttcatcat 3159241 cggtacagga agcgtttttg agttgaatcc tccaaggtat tggtaaagag gaatctgtaa 3159301 gaaatcagca gcagcacgcg cacaagccat agatacgcca aggattgcgt tcgcaccaag 3159361 tttgcctttg ttttcagtac cgtcaagctc gattaaaagc tgatcgattg cgttttgttc 3159421 agttacatca aagccaagaa gctctggagc aatgatttcg tttacgttgt taacagctgt 3159481 taacacgcct tttccaaggt aacggtcttt gtcgccgtca cgaagctcaa ccgcttcgta 3159541 ttcacctgta gaagctccgc ttggcactaa tgcgcggccg aaagctcctg tttctgtata 3159601 tacttcaact tcaactgttg ggttgccgcg ggagtctaat acttcgcgtg cataaacatc 3159661 aacaatgtat ggcatgagtt ttgtctctcc ttttgatttt caaattattt ttgaattaaa 3159721 gatgttcctg tcatttcttt cggtttttca acaccaagaa ggtctaataa cgttggtgca 3159781 aggtcgccta ggattccgcc ttcacgcagc gtaatgcctt ctttcgttac aatcacaggg 3159841 actgggtttg ttgtatgcgc agtgtgcggt tcgcctgatt ctgtaatcag aatgtcagca 3159901 ttaccgtgat cagcggtaat gatagcgtgt ccgcctttag caaggatcgc gtcaacgact 3159961 tcgcccaagc attcgtccac tgcttcaatt gctttaattg ttggttcaac cattccggag 3160021 tggccgacca tatcagggtt tgcgaagtta agaatgatcg cgtcatgctt gtcagcttca 3160081 atttctttga caagcgcgtc tttcacttca tacgcactca tctcaggctt caagtcatac 3160141 gttgcaactt taggcgagtt gatgagaata cgctcttcac ccgggaattc agcttcacgg 3160201 ccgccgctca taaagaacgt gacgtgcgga tacttttcag tttctgcaat tcgaagctgt 3160261 tttaacccgt gctgagataa tacttctccg actgtgttat caagatttat cggtttaaac 3160321 gctacatagc cgtcaactgt ttcactgaag tgagtcaggc agacgaaata caggttcttt 3160381 ggataattct cgccgcggtc gaagtcacgg aagtctttgt ttgtgaacgt gttggaaatc 3160441 tggatggcgc ggtccggtct gaaattatag aaaatcacag aatcgccgtc ttggattttc 3160501 gcaacaggct caccgttttc ttttgtgatg acagatggaa tcacgaattc atcgtagata 3160561 ccatttgcat atgaatcatc aacaacatcc agggcgctgc ggtaagatgg gccttcgccg 3160621 tacgccattg cgcggtacgc tttttctaca cggtcccagc gtttgtcgcg gtccatagag 3160681 tagtaacgtc cggaaatgct ggcgatttca cctacaccga tttccttgat ttgatcgttc 3160741 aactggttga tgtacgtttt cgctgtctgc ggacctacat cacggccgtc aaggaagcca 3160801 tggatataaa cctttgtcag cccttctttt ttcgcaagct ttaacagtgc gaataaatga 3160861 ttgatatggc tgtgcacgcc tccgtcagat aaaagaccga acaggtgcaa ggctttgttg 3160921 ttttctttcg cgttgctgat cgcgtcaagg aatgtttgat tgcgttcgaa ctctccttca 3160981 cgaatggcaa catttacgcg tgttaagctt tggtacacaa tacgtcccgc accgatattt 3161041 aagtgaccta cttcggagtt ccccatttgc ccttcaggaa gacctacagc ctcgcctgaa 3161101 gcagtcaaag tttgatgagg atactggttc caatagcggt caaaattcgg ttttttcgct 3161161 aaagcgactg cgttccctac tgtttcgtta cgtaatccga acccatcaag aatgatgagt 3161221 gcagctggtt ttttactcat attgaccttc ctccaataat tgaacgaatg actgtggctc 3161281 aaggctcgcg ccgccgacca aagcaccgtc aatatcggac tctgccatat attctttaat 3161341 gtttgcaggc tttacgcttc cgccatattg gatgcgaagc ttgtctgcag cttcttggct 3161401 gaagctttca gcgacggttt tacggatatg cgcacacacg tcattcgcat ctttcgctgt 3161461 agaagatttg cctgttccga ttgcccagat tggctcatac gcaataacag aagcagcaac 3161521 ttgttcttca gaaagaccag caaggccttt tttcacttgg tcagcaacaa gatcatttgt 3161581 tttgccggct tcacgctctt caagcgtttc acctacacag atgatcggca caatgccgtg 3161641 tttgaaagct gcgtgtgctt ttttgttaac tgtttcatca gtttcagcga acatttcacg 3161701 gcgctcagag tggccgatga cgcagtagtc aacgccaagg tctttcagag caaccgggct 3161761 gatttcgcct gtgaacgcgc cgctttcttc gaagtgcatg ttttgagcgc cgacttttag 3161821 gtcagtgcct ttcacagcag aagcaagctt ttctaagaaa agcgctggcg cgcaaacaac 3161881 agcttcagct ttgtctgctg ctggaatgga agatttcact tcttcaacga agctgacagc 3161941 ttcgccgagt gttttgttca ttttccagtt accggcgata attggttttc tcatctgttc 3162001 cacttcctta tagcagtttt gagattattt atcgttcagt gcagctaccc ctggaagctc 3162061 tttgccttcc ataaactcaa gggatgcgcc gccgcctgtt gagatgtggc tcattttgtc 3162121 agcaaggccg aatttttcaa ccgctgccgc agagtctcct ccgccgatga cagagtatgt 3162181 atctttcgcc tctgccaatg cttccgcaac cgcttttgtt ccttgagcga acaagtcgat 3162241 ttcgaatacg cccattggtc cgttccacac gacaagtttg ctgtttttga tgacgtcagc 3162301 atacgtttcg cgtgttttcg taccaatgtc gattgcttct aaatcactag ggatttcaga 3162361 gatcggcaca attttcacgt ttgcatcgtt agagaaatca tctgcaacga gtacatcttc 3162421 aggcatgtag aagttaacgc ctttttcttt agcgcggtcc ataaatgatt tcgcaagctc 3162481 gattttatcc tcttcaagaa gagatttccc gacttcatag ccaagcgctt ttacgaaagt 3162541 ataagcaaga cctccgccga tgatcaggtt gtctacttta tcaagaagac tttcgattac 3162601 accgattttg tcttttactt tcgctccgcc gatgatcgct gtgaacgggc ggtcaggatt 3162661 ggaaaccgct tttccaagta catcaagctc tttttccatt aagaaacctg caactgctgg 3162721 cagatgctcg gcaattccag ctgtagatgc gtgagcacgg tgggcagcac cgaatgcgtc 3162781 atttacatat acatctgcaa gctcagcaaa tgcttttgca agctcaggat catttttctc 3162841 ttcaccagga tagaaacgta cgttttccaa tacaagaacg tctccgtcct tcatctcaga 3162901 aatttgtgct tttacagcat cgccgtatgc ttcatccgct tttttcactt ctttgccaag 3162961 cagttcgccg agacgtgcag cgacaggagt taaacgaagc tcctcaacca cttcgccttt 3163021 cgggcggcct aagtggctcg caagaaggac ttttgcgcct tggtctgcaa ggtgtttgat 3163081 tgttggaagc gcagcacgga tacgtgtatc gtctgttact tccccgtctt tcattggaac 3163141 gttaaagtca acgcggcaga atacaacttt gccttttacg tcgatgtctt tgagagtttt 3163201 tttattcatg cctaggagat cctccttcaa aatggtttgc atacagcacg aaaaacgtga 3163261 aaccgtctgt tcaagcgata actccgctag ggcagatcgc agtctttttc ggcacagggc 3163321 agttcgtcta aaagccaggg cagcggcctt aggcgaaagc gccggcaaag ctgcttaaaa 3163381 cgcggtcgtt tctctatcac agagcgtttt ctgaaagccg gtcttcatgg aaaaagggaa 3163441 agggagtccg tccccttccc ttgtccgctt tcattatagc gcttctattc gaaagaacca 3163501 agtcaggtcc tttttcagct ataaattaaa gacctttttt tgcgatgtaa gctgcaaggt 3163561 caacaacgcg gttagagtag ccgctttcgt tatcgtacca agagattact tttaccatgc 3163621 tgccttccat aaccattgta gaaagagcat cgattgtaga agagtttttg tttccgttgt 3163681 agtcgccaga aactaatggc tcttcgctgt agccaaggat tcctttaagg tcgccttcag 3163741 ccgcttcttt aagagctgcg tttacttctt cagctgttac ttcttggttc agttcagcaa 3163801 ccaagtcaac tagagaaacg tttggagttg gaacacgcat tgctccaccg ttcagtttgc 3163861 cttttagttc aggaagaact agagaaactg ctttagcagc accagttgat gttgggatga 3163921 tgttttcagc tgctgcacgc gcacgacggt agtctttgtg cggaagatca aggatttgct 3163981 gatcgtttgt gtaagagtga acagttgtca tcataccgcg tttgatgccg aatttatcgt 3164041 taagtacttt tgcaaacggc gcaaggcagt ttgttgtgca agatgcgtta gagataacat 3164101 cgtggttagc cgcatcgtat ttatcttcgt taacacccat aacgattgtg atatcttctt 3164161 cgttagcagg agcagagatg attacttttt tcgcgccagc ttctaagtgt ttcgcagcgt 3164221 ctgcgcgttt tgtgaagaaa ccagtagatt caactacgat ttcaacgcct tgtttgcccc 3164281 agctaagttt agcaggatcg cgttctgcag aaacttcaat tgttttgccg ttaacaacaa 3164341 ggttgttacc gtcaactgaa acttcagcgt ctaattttcc gtgtacagaa tcatattgta 3164401 aaaggtgagc cagcatgtta gcatctgtta aatcgttaac cgctactacc tcaacttcag 3164461 gattgtttaa tgctgcgcgg aatacgttac gtccaatacg accaaaaccg ttaataccga 3164521 cttttactgc catgattgtt tcctccttta aataagtgag agatatttat attgagggat 3164581 tattcatccc ttaataactt ctttgcggct ccttcgtctg tgacgagaac cgtgttgcgt 3164641 ggctttttaa agtaagcctc gatcgcttcg gcttttgatg atccgcccgc taccgcaata 3164701 atatcgggga tggcgtctat gtcatccagc tgcattccga cagaatgcac tttgtgaacc 3164761 acttcgccgt ccgcgttaaa atagtagccg aacgcttccg tcaccgcgtc gttatcatct 3164821 attttcttta aatcttctaa aggcgtgttt ctgcgctgag ccatagtttt agcttcgccg 3164881 attccgtgaa ccagcatact cgctgattta atggtgttca gcacctcttt gacagaaggc 3164941 tcttcaataa tagatgaata ggcgccttgt gacagctgtc ccggaacaaa caaaagccgg 3165001 taagtgcctg aagccttctc cgccatatgc gcgcatatgg tgttcgcctg gtttttcacg 3165061 tcttcgccta aaccgcctct tgcaggcaca aacaaaagct cgcggttttt agaatccggc 3165121 gtcatcattt cggcgacagc ttcaattgtc gtaccgccag ttacagcgac gatatttttg 3165181 cctgaaaatc tttttttcat acatgcgaca gccgctcttc ccatttcttt tttgacccat 3165241 ggggattgat cgctgtctcc ggatacgata atggcatcct ttagatttaa acgttctttt 3165301 aatgtctttt ccaaaagagt caaacctaaa acatctttca tcgtatcttc caaaacagaa 3165361 agcagttcat agccctcttc tgtcaatgtc atgccgtttg tcttaatatc gaccaggttc 3165421 tgttccttta aaaactgaac ctcgcccctc agcacacgct cgctgattcc gagactggca 3165481 gacaggcttc ttcgcccgat gggttctgtc agcctgatat actgcaagat ttcaaacctc 3165541 ttttgcataa cgagcagaag atcaggcaat aatttttttt gagcttgtat taactggttc 3165601 atgactcaaa cgttccttcc ttttttgctg gacattatat gtcccgctat gacaaaaaac 3165661 gtcccgtcat agccaaaaaa aatcatttct gctttcttta attattttaa cagggtggaa 3165721 ttgtttattc aactgttaag agccaattca tcgacaatat tcgcagagtt ttcatgccgc 3165781 gtcgttttat ccagcaatat tttatcctat atatctttat cttatacaga aagcgccaaa 3165841 tggtgcatcc caatataaac agcccttccc gtagaaaggg ctgtttcatt aaagcgtttt 3165901 cattttatcc aaagcttttc aatttcctcg agcgatttgt tcttcgtttc tggacagatc 3165961 gtaacgacaa acaggaaaca aaggatgtta atcaccgcaa agatccaaaa tgtataggcg 3166021 agcccgaaag aatcgatcat cattggcaca aactgtccga tcgcccagtt tgctccccat 3166081 aaaaagatgg tcgcaatgcc cgcggcccgc gcacgcagat ggttcgggaa gatttcagaa 3166141 atcataatcc atgtgatcgg tccgaccgag acacagaaag cagcgacaaa acctaatata 3166201 aggacgatca tcatgatccc gcttgttaac tcaaaataaa acgacgtccc gattaaaatc 3166261 ataaaaatag ccataaaagc agaaccgatg gacatcagtt tttttcgtcc gactttatca 3166321 atcagcaaca ccgcaataac ggtaaaaata acttctacaa ccccgacgat acaagtcgtc 3166381 acaaatccgg cgttttgccc gaatcccatc attttaaaga tttccggccc gtagtaagta 3166441 atcgcgttca tgccgatgac ttggttaaac agcgccagca ggattccaat gacaagcgcc 3166501 tttctgagac ccggcttaaa cagctgggag agcgacccca tttgttctat ttttaaagag 3166561 ttctcaatgt tctttaattc ttcttttgca acagtttctc cattaatacg tgtcaggatc 3166621 tttaaagctt catttgtttt gcccgctttc gccagccatc tcggactttc cgggacgacg 3166681 agcaggacaa ggaaaaaaat gacggatggc accattccat aagcaagcat ccatctccag 3166741 ccggtgtgca cgccccattc gtatgttccg gaccgctgca cagctagatt aataaagtat 3166801 gttgcggaaa tacccagtat cgtaaagagc tgatataacg aagataaact tccgcgtata 3166861 gcgggcggtg ccgcttctgt aatatacgta acagagagcg atgagcccat cccgattccc 3166921 agccccccga taatccttgc aatgattaag gtggacacgt cttgagaaag cgctgaaacg 3166981 attgctgata tcgcaaataa caaagcggct gtcattaaaa tttttctccg gccgaatctg 3167041 tcacttaaaa atccggatat cccgacgccc acaactcctc caatcataat gcttgaaatg 3167101 acaagtccct ccataaacgg actcaggctg tataaatctt tcagaaaacc gatggcgcca 3167161 gaaatcactg ccgtgtcata gccatacaat aagccgccaa gccccgccgc acatgagatc 3167221 aaaatgacaa atcccattga atggcttctt gttacaggaa catttggttc taattgagtt 3167281 ggagtattct tcatttccct gccctcccga atgttgagta aagcgttttc atttaaacct 3167341 tcaattgtac gtacttatat taaaatttaa cgaaaattac atttaattag tacgtacaaa 3167401 tatagaataa tcttgtttgc attttctgtc aatgttttct tacaaagaac gctgtgatat 3167461 actgaaattt gtccgtatac attttggagg aatggatatg ttaccaaaat acgcgcaagt 3167521 aaaagaagaa atcagttctt ggattaatca aggcaaaata ctgcccgatc aaaaaatccc 3167581 taccgaaaac gaattaatgc agcaattcgg cgtcagccgg cataccatcc gcaaagcgat 3167641 cggagacctc gtatcacaag gtctgctgta cagcgtgcaa ggcggaggca cctttgtcgc 3167701 ttcacgctct gctaagtcag cgctgcattc caataaaacg atcggtgttt tgacaactta 3167761 catatcagac tatattttcc cgagcatcat cagaggaatc gagtcctatt taagcgagca 3167821 ggggtattct atgcttttga caagcacaaa caacaacccg gacaatgaaa gaagaggctt 3167881 agaaaacctg ctgtcccagc atattgacgg actcatcgta gaaccgacaa aaagcgccct 3167941 tcaaacccca aacatcggct attatctgaa cttggagaaa aacggcattc cttttgcgat 3168001 gattaacgcg tcatatgccg agcttgccgc gccaagtttt accttggatg atgtgaaagg 3168061 cgggatgatg gcggcggagc atttgctttc tctcggccac acgcatatga tgggtatttt 3168121 taaagctgat gacacacaag gcgtgaaacg gatgaacgga tttatacagg cgcaccggga 3168181 gcgtgagttg tttccttctc cggatatgat cgtgacattt acaacggaag aaaaagaatc 3168241 aaaacttctg gagaaagtaa aagccacact ggagaaaaac agcaagcaca tgccgacagc 3168301 cattctttgt tataacgatg aaattgcgct gaaggtgatt gatatgctga gggagatgga 3168361 tcttaaagtg ccggaggata tgtctattgt cgggtacgat gattcacatt tcgcccaaat 3168421 ctcagaagtg aaactaacct ctgtcaaaca tccgaaatca gtgcttggaa aagcagccgc 3168481 caaatatgtc attgactgct tagagcataa aaagccgaag caagaggatg tcatatttga 3168541 gcctgagttg atcattcgcc agtccgcacg aaaactgaat gaataaaaaa agcaatgtat 3168601 gggtctcccc gctacattgc tttttttata gctgttatct gtttttccaa acgtcagcga 3168661 tgatttcaaa cgaacgcatt ctgtctgcgt gttcaaaggt ttctgagtta accataattt 3168721 cgtcagcctg tgtcgttttg acgaaatctt caagcttcgc cttcacttct tccggacctc 3168781 cgacaatcgt ggagctcagc tgctcattga ccatcgcttt ttcatacggg ctccagattt 3168841 ggtccatatc ctcaacaggc ggtttaagct ggttaggcgt accgcggaca agatcaagaa 3168901 acctttgata atgggaagtc gcaaggtgct gcgctttctc gtttgtatct gccgcgataa 3168961 tggtgacacc gaccatcgca tacggttcgt cgagcacgtc tgacggcgtg aaggaattgc 3169021 ggtacagctc caaagcggga accgtattcg ccggtgagaa atgggccgcg aacgcaaacg 3169081 gaagaccaag ttcgccagcc agacgggcgc tgaagccgct tgagcccagc agccaaatcg 3169141 gcacatctat gccctctccg ggaatggcgc gaacttgatt gcgcacattt cctgacggtt 3169201 taaaataatt gcgcagttcc tctaattgtt ctggaaaatc ctccccgctg ttgatgtttc 3169261 tgcggagcgc tctggctgtc aattggtctg ttcccggcgc acgtccaagc cccagatcaa 3169321 tccgcccggg atacagtgtt tccagtgtgc cgaattgttc agcaatgact aatgaagagt 3169381 ggttggggag cataatgccg ccggaaccga cgcggatttt cttcgtgcct ccggcaatat 3169441 ggccaatcaa aactgcggtg gcagagcttg caacaccttc tatattatga tgttcagcaa 3169501 gccagtaacg gtgatagccc cattcctctg cccggcgcgc caagtccatg ctgtttcgga 3169561 atgattctgc aatcgttcct ccctgaacaa ccggagataa attcaagaca gaaagcaagg 3169621 tatctttgcg ttggttgtta gacatattgt tctcctttgc aaatgtgtta tcagtaaaca 3169681 gcccaaagct gtcaggtcat gattgaaaga acttctatca caccataaca caactgcatt 3169741 caggaataaa agaatttgat tcgatgaaat tcgaacaata taaaacgaac ggtttggaac 3169801 attattctgc tccaaacaac tccttagcca tctcaataaa gagcttagcc gccagagaag 3169861 cctcctttag cgacggaaca gcaagctgca catcacggta tacctgcggg tccaattccc 3169921 tggtcaccac atgctctggc agcggcatcc ccgacatgga catttctgat aaaatggcca 3169981 ggcccaggcc ttctctgatc atactgatcg aggtgttgat gttatagacc gtgaaagctg 3170041 ggtgcagcgt agcacccgcc tgcctgaaca tatcgataaa tggtgattca tagccgccgt 3170101 cacagacgat catcggttca tggtcaagat ctttcagcgt aatggctgaa tgactggcaa 3170161 gcgggtgatc gtccctgagc acgacagcca ttttgtcttt tttcaaatga atgtactcca 3170221 tctcctctgt tggatacaga agaatcccaa catctatcat ccgcgtatga agccactcct 3170281 tgacttcatt tacagttccc tcgtgcagca cgagctcaag tttcggatat ttttgtttaa 3170341 attcactgat cagcttcggc ataaaataag ccgaggcagt tgagaatgtg ccgatatgga 3170401 tcgttcccag ttcaagccct ttttccgctg ctgctacctg ctcaactttt tcaatgcctt 3170461 ttaagacttc tctgatgtgt actaagatct gttttcccgt atccgtcagc atcaggccat 3170521 tgcggcggtc acgaatgatc agctttacat caagctcagc ttcgatcgca gaaatcgcat 3170581 ggctgacagc cggctgtgtc atgttcagcg cctgacccgc ttttgtaaag cttcccgttt 3170641 cagctatttt cacaaaaacc tttaattgag taatggtcat aacaatttac ttatgctcct 3170701 tataaaaaag attcatttta tttatcttat gttctaccgt atcatatgat ggaaaagttc 3170761 tacaaggagt gaatgaacaa tgaagcagct cccaaaaacg cggacagctc tcctgctcgc 3170821 atttctcgtc atcatgtggg gcgtcaattg gccgctgtcc aaagccgcgc tcgcctattc 3170881 tccgccatta ttgttcgcgg gcatccgaac gctgatcggc gggcttttat tagtcatagt 3170941 cgcactgccg cgtattcata aattacgctt aaaagaaacg tggccgattt atcttgtttc 3171001 tgctctttta aatattacat tattctacgg cctgcaaacg atcgggctga attatcttcc 3171061 ggccggcctg ttttctgcaa tcgtcttctt ccagcctgtt ctgatgggtg tattttcttg 3171121 gctgtggctc ggcgaatcca tgtttgtaat gaaagtgatt ggcctcatcc tcggttttgc 3171181 gggagtagcc gtcattagtg ctgcgggctt tggcgggcat atttctgtca ttggggttct 3171241 gctggctctc ggctccgcag tcagctgggc gctcgggaca gtatatatga aaaaaacagg 3171301 cagccgcgtc gattccatct ggatggtcgc tctgcagctg acgatcggaa gcgtgtttct 3171361 gcttatctcc ggcttttgga cagaaagctt ttcggcgatc caatggacag ctccgtttat 3171421 tacgagcctg ctgttcatct ccgtattcgt tatcgcactc ggctggcttg tcttttttac 3171481 gcttgtcggt tcaggagaag caagcaaggt cgcatcttat acttttttga ttccgctcat 3171541 atcaatcgtg gccagctcca ttttcctgca tgaaccgctc acccttagcc tcttggcagg 3171601 gctgctgctg attgtcacga gcatctgtct cgtgaataca aaatcaaaag cgcagaaagc 3171661 tgcggcgatt ggtataaacg agaaagctgc acaataataa aaaccctctt gccggatgcg 3171721 gcaagagggt ttcttattta ctgatgcttg cgtcctttga ccaaatatgc aactgtaatc 3171781 aaaaggtaga tcgccgcagt aatgccggta atgacaattg atgttgtcat gatgaccccg 3171841 atcagaatgg cgagtaatgc cacaatcgca aaccatgtcg tgtacgggaa ccattttaca 3171901 taataggccg gtgtttccgt ttgctgtttt ctcgatttta aatgagcgaa tccgatgatc 3171961 agccaaatga ataaaacggt atatcccaat gatcccatta aataattaaa tgtttggctt 3172021 cctgcgaaca gagaaatcaa tacgccaata tagagagaag aagtgcacat cagaatcgca 3172081 aacatcggta cgtttttcga tgaaagcttc gagaagacct ttggaagcct tccgtcactt 3172141 gcctgtgtat acaaaatgcg tgatgatccg tataaacctg aattcataga agaaatgatc 3172201 gccagcagga tgactgcatt catgatatga tccgcgcccg gaatgcctac cattttaaag 3172261 accatcacga aaggactttc cggaacggaa ttgacttggt tccatggaat caggctgacg 3172321 atgatgaaaa acggcagcag gtaaaacgcg acaatccgtg tcagtgtgct gcggacagct 3172381 ttcgggacaa ccttttccgg attttttgtc tctgcaagcg ttacaccgat aatttctgta 3172441 ccgccgtaag agtagatgac gacaagcatc gccgtgatca gccctgtgcc gccgtgcggg 3172501 aaaaatccgc cgtggtctgt caggttggaa aatccggatg ctgtatgatc accgaatgat 3172561 acaaataaga gcagcaatcc cagaataata aagataataa taacggtaat cttgatcatt 3172621 gccagccaat attcagtttc ggcgaagatt ttaacagaaa gcaagtttac aatcgtgacg 3172681 ataagagaaa ttcctaatgc caacacccag atcgggcagc ccggcagcca atattgaatg 3172741 aaaatcgcag ctacaacagc ttcagccgca atgttaagca cccacatttt ccagtagatc 3172801 cagtccaaaa agtaagcagc gtaatttccc aatacctgct ggacaagatc acggaaggtt 3172861 ctggcgttac ggtttcgaac agccatttcc gccagcccct gcataataaa cagcaaaata 3172921 atcccgccga gcaggtatgc gataatgaca gatggccctg ccacatcgat cgctgagctg 3172981 ctccccttaa ataaacctgc gccgattgct ccgcccagcg ccatcatcat aatatggcgg 3173041 gacgtcatcg tgcgttttaa cgtttgattg tcgtttttca tcctcttcta cctctccttc 3173101 tcgttttcaa aaacaaaaaa gcccgccgtc tcctacctaa tctaatagat aaagagacga 3173161 cgagccttcg gctgaccgcg gtaccactct tgttgattct tcatgaagaa tcctgctttt 3173221 gacctgtaac gaaggttagc cgttaaaaca tagggaatat tcaatctatt ccgttccgtc 3173281 ttaccactcc cgggcgagtt caaagaagaa tcaggctgcg tcgcaccacc ccgcagctct 3173341 ctgttctgat cactttcttt tactgctccc aatctatgtg ttttagtttt ctgaaaaact 3173401 caaattttat gatctgaata tattaacata atatacgtgc ttctctttta actgtcaata 3173461 acttcagaga aaaaagaaac tgttattttg tcccttttcg aatggctttc caaaaggatt 3173521 ctgactcgtt tcctaatgcg taaactgaaa cacctgctat tttatattgc tttgccagat 3173581 ggcttttcgt ttgaacggtt ttttcgtttt cataccacac gacatgttta tgcttctttt 3173641 tgtcaacata agaaaacgtc atcgagcctg attttttgtt gaatgccggc tttgcttttt 3173701 gttttttgat gagggatttg agctcattcc attcccttat tgtgctggta cttccgtctt 3173761 ttacatccca gtcatagccg tacgcaggga ttcccatgat gactttattg gctttgatct 3173821 ttttgactga aaactgcaga gagcttttga tccagtttgt gcttgccact gaccccggct 3173881 caccccaaat gccgtgttca tcgtaggtca tgacttgtac gaagtcggca tatttgccga 3173941 ttttcgcata atcatacggc cagctccagt catcattttt atcatcggcg cttttggccg 3174001 gaacggatac cattgtttta atatgtttct tattcaaagc ctgtgagaca tattgaatga 3174061 agttcgagta tgcagcgcgg tcttctggat ttactgcttc aaaatcgata ttgattccgt 3174121 aatatgagtg ctttttggcc agtgtaatta actgatctgt gaatcgtttt ttcgctgttt 3174181 tattgctcat gacccgactc gctaaatctc cgtcaaaatc ataaatggca tcattatagt 3174241 ttgaaatgac agcccatgtc ttgatttttt tctttttcgc atatgtcagc tgcttagttg 3174301 gggcatcgcc aatgatttgt ccgttttttt caaacgcaaa tgtatcggtt gcgatggcat 3174361 tcatgtatgt atgatatttc gtaagagaat tgtatgaagc cgtatcccca gtcgtgtagc 3174421 ctactgtcat accggctgcc ttcgcttctc cttttgtata cataaacaga acaatcgcaa 3174481 tcgccagtga aaccgctatg atcagccatt ttttcatcgc atttcctcct gtatcaagtc 3174541 atactcttct catcggccaa aaaattggaa gttgaagttt tttcaagcaa aaagcccggc 3174601 atatgcctgc cgggcttcct gagttcagcg gtcagagacg agaatatatg ctgcctttac 3174661 tggtccatgc acccccacaa ctaaatccat ttcaatgtcg gctgagttac tcggtccggt 3174721 aatgtagttg atacatgaag gaacagtgac accgttcgca atgttttggc ggatgatatc 3174781 actggcttgt gtcattctcg gtacaatgct tgatttcggc acgatcgcaa tataagtcgt 3174841 tggcaaaagg ctgacagagc ggccgatgtc ttttgaggag aagaggacaa ccgtccccga 3174901 ctcagccaat gtaatttcgc tgaatgtaat ccctacattg gcttgctccg cttttttaat 3174961 attttcctcg cctttgtcag catcccactc ccagaccggc gttccttcac tcggccagtc 3175021 cttggtgagc aggcttttca gtccgtattc ttcaaagcgg gggtccttcg gaatgatgac 3175081 agggcctcca gaaaagcggc tgacttgctc gcgcagggca tcgtaaaggc cggttgaatc 3175141 cgtttcaatc agctctgtat ggattttgac acaatggttt ttgagcactg tgactaagtc 3175201 atccgctgaa taaccttcaa gtgttttata ttgcggctga tgcgcccatt cagggactgc 3175261 cacgcctcct gttcttcgtt cacggcccag gctggatgcg attcggttta aaaagctctc 3175321 ttgattctga atggttccct tcgtcatcac tgctcctcct tcgtgcgttc acttgtttct 3175381 ctgtccgcaa accagtctct gaatctcgat ttatgcggtg ccgggaagtc gcgaatctgg 3175441 gtccaatttt taagcgggcc gggccctttc gaaatttttt cgtcctctgt aaaaggcgtc 3175501 atggcggccg gcgcccattt tgagcccatt ttgtaaagcg ataaggagga tgcgccaagt 3175561 ccgaatgctt tcattgcaag cttttcactg atcggcgccc tgccttcttt ttcgacgata 3175621 ttctgacgat gcttgagtag cagctcatga agcgggattt tgaccgggca ggcttctgaa 3175681 caagcagcgc acagtgaaga tgcgtacggc agctccttat aatcgtcata accgccgagc 3175741 aacggtgata aaacagctcc gatcggcccc gagtagattg agccgtatga atgtccgccg 3175801 acatggcggt acacaggaca gacattgata caggcggcac agcggataca ttgcagcaca 3175861 gactggaatt ccgttccaag gatattggat cgtccattat caacgatgac aagatggaat 3175921 tcttccggac cgtccacttc accttccagc ttcggacccg tcaaagctgt aatatagctt 3175981 gtcagccgct gtccgacagc acttctagtc agcatgctga ctagcacttc aaattcagaa 3176041 aatgacggga caatccgctc cattcccatg acggtaattt gtgttttcgg caaggtgctc 3176101 acaagccgtc catttccttc attggtcaca aggctgacgg aacccgtgtc agcgatggcg 3176161 aagttacagc cggtaatgcc gatatccgct tccagaaact ttttccggag aatggcgcgc 3176221 gcatgcatca ccagctcttc cggtttttct gtatgttgat agtccagtct ttctttaaac 3176281 acatcgcgta tctgctcttt atttttatga agagcgggcg ctacgatatg tgacggcgga 3176341 tcgtgatcat caatctgcaa aatatactcg ccgagatcgg tttctacgac ttcacagcct 3176401 tccttctcca gcacctcatt cagattgatt tcctctgtga ccattgattt agatttcaca 3176461 attttcttcc cgttcttctt ttgaatgaca tcccgaatat aggaagacgc ctcttccgct 3176521 gttttcgcga aatagacatg tccgcctctt ttcgccacat tttcggcaag ctgtccgaga 3176581 tagaaatcaa ggttttcaag gacatgctgc ctgatttcct ctgataatga gcgccactcc 3176641 tcccagtttc ccagttcttc tgctgcctct aggcgccgcg tccgcagacg ctcctgtgca 3176701 cctgaaacag cgcctctcat aaattcatta tcaatcccct gtgatacccg ctctttaaaa 3176761 gcgtcagtac cgattttcat cgccatgatc ctttccccct ctgaatccag ttttatctgc 3176821 tgttgagcac ttcggcgatg tgcatcactt tgacattctt atcttttcgg ccaagccgtc 3176881 ccccgatatt catcaaacag ccgcagtcag caccgatcag cacctctgct cccgtttcct 3176941 ccacacattc gactttttca tcgaccatct gctcagaaat ctgcgccatc ttgactgaga 3177001 acgttcctcc gaatccgcag cagttatgtt tgcccggaag ctctgtaaac tgcaggccct 3177061 tcacatggct caacagcttc atcggctcct tccgaacacc cagcagccta gtcatatggc 3177121 acgacgtatg taaggtcgct tttgtatgaa gggtcgcgcc gacatcctct accccaagga 3177181 cgttcacaat aaaatctgtc agttcatacg ttttatccgc cagctttttc gctttatcgg 3177241 cccatttcgg atcatcctga aacaggtgcg gatactcccg gaacatcgtt gtgcaggaac 3177301 ccgaaggact gacaacatat tcggaatcct gaaacgtttc gatcatccgt ttcattgctt 3177361 ttttggcgtc atgtacatag ccgctgttgt aagccggctg tccgcagcaa atctgccctt 3177421 ctggaaaatc aacctcgcac ccaagccgct ccagcagctc aaccgttgct tttccgacat 3177481 ttgtttgaaa catatcaaca agacaagtga caaaaagtga gactttcatg atgaacccct 3177541 ctctcatccc caatatatga tcaggtcatc tgatgacctg agttaaaata actatatgaa 3177601 tatcgtacac tattctgaca atggaaggaa agagttttct agggatattt tcatttgtgg 3177661 catatcaaaa acactcccga tctcccagga gtgcagtata tggttagatc cagccctttt 3177721 cctcagcgat gctggcggct tctgtccgat ttttcgcatt aagcttttgg atgatttctg 3177781 agatatagtt tcgaactgtg ccttgagata aatagagctc cagcgtaatg tcttttgttg 3177841 tcttgcctaa agccgcaagc ctcagaattt cttgctctct aacggttagc ggattttcgt 3177901 ctcgcatcat attaaacgtc agctcagggc tgaagacacg ttttcccttt acacattttc 3177961 gaatggcatc ggccagatcg tcaatttcac cgtctttcag cagatagcca tgtgcaccgg 3178021 cctttacggc gcgttcaaaa tatccggggc gggcaaaggt ggttaaaata atgaccttgc 3178081 tgacgcagcc ttttttcatt aattcctctg ccacattcag cccgcttcga accggcattt 3178141 caatgtccat aatgcataca tccggctcca gcttcaaaat agcatgtagc gcctcttccc 3178201 cgtttaatgc ttgtccgatg actgtcatat cctcttctaa atcaagcaaa gatcccaaag 3178261 cgcctaaaag cattcgctgg tcctcagcaa taaacagacg aatcattctt ttcgtcctcc 3178321 aatcattctg cttttttaat aagcggaatc gtcagtgcca caaccgttcc gttatggtct 3178381 gaaaccgtta atcccccttc aatgagcatg agccgttctt ccattcccca caggccattc 3178441 ccaaacattt tctccttcgg cgctcccttt ccgtcatccc gtattacgat cctcattttg 3178501 tcagcaaatt gagaaatggt gatggcacag tgggttgctt tgctgtgctt gataatgtta 3178561 gtcacggctt cccgcataca catactgata atattttgag tgacgggaga tatcactgaa 3178621 aagtcgtcgg ctccttcgta ttgaaaggta atgttccccg ctcttaatat gtgctgaatg 3178681 tttacgagct cctctgttat cgtgaccgtt ctcatatcag aaaccagctc tcgaacttgc 3178741 ttgagtgcgg agcgtgaact ggtttccatt tcttttgcct caagcttggt ccgttctgga 3178801 tcagatgcag ccagccgctg aatgagctgg ctttttaatg taagcagcga cagggtgtgg 3178861 ccaagagtat cgtgaagatc acgggcgatt cgaacacgtt cctccctttt agagagttct 3178921 tttatctgtt cgttggcttg tgcaagctta gcttcaagct caatcctccg aaacatagaa 3178981 cgaattccga atggagaaat gagcataatg acgagaaacg ggagaacaga aaaaagctcc 3179041 cgaagcgaga ccgaattcgc gataaattgg tataggcatg gaaaaagcag tataaagatt 3179101 aaagcgcaga acgcacggtt aaaattcgtt ttctctttgt aataaccaac aaagtttgcc 3179161 ggaaaaaaac ctaagtatat ataggtgata ttgtaaaaca cactatacat caaaataacc 3179221 gccatttgca cgataagcca atatgtaaac gaagctttgc ccacgctgca gaataactgg 3179281 cgatatgccg ctacaaaaag gagcagcata ccatatccga tcccctgttt gacccctgat 3179341 tcttttaata aagagaggaa cggcataatc gtatacacca gaaagatata agggaaaaac 3179401 ccgaattcct tcgggaaaat agatattgcc tttttcatgt attacaccgc ttcttgtttt 3179461 cttcttatat atttagatag tagcatgaag agcatcatat aagcgattaa tatcagaata 3179521 tttttccaag tcggactccc accccggaca agttcccacg ctccgctccc gaaatgataa 3179581 gacggaagcc actggccaat gctctgcatc atgtcaggca tgacctcaaa cggcatccac 3179641 atccctccgc ctaaagccag cagcatataa agcacattac tgattccggc cgctgtttct 3179701 acttttctca tgaggccgat tagtgtgcct aatgctaaaa aaggcaatgc gccaaacaaa 3179761 atccacagtc cgctcatcat ccattcaaac ggtgacaagg caatatcatt gatgattgcg 3179821 ccgaacagaa atatgacggt aattgataaa acgtgaatga cactttggcc gatcatctga 3179881 gctgataaat agatatgatc cggaagaggc gtaaggcgga taaaggcggc ccagccttgt 3179941 gaccgttctt gtaccattcg gatgccaagc gtcatgatag aggaacccat cacgctgaag 3180001 actgtcatcg acatcaggta atgggcttcc catgcacgtt gatcagggac gttggtattc 3180061 actacatttg taaagaaata ataaaaggca atcggcatga tcagagacca aagcacaaag 3180121 tacttgttcc taagcaccct tttcatttca gcgatgcttt gcttttgcag cacgttcact 3180181 cacatcgcct ccctgttgcc gtcagccagc tggcgaaatg cctcatcgag cgttgcttgc 3180241 tcaattcgaa tatcccgtgc atgtatgttt tcttgaaaga tcagcgccaa cactttgtct 3180301 gtatttgatg tctggatgat ggttctctca tgctcgtgga tcactctctc gacttccggg 3180361 tgacaagaca gcctttccaa tgattcactt gaatgaagcg taaaggaaac agactgtttt 3180421 tgaattcttg agcggatttg cattggtgag ccgtctgcaa caagctgtcc ttcagtaaaa 3180481 aataggattc gctgtgcggc atcatctgct tcctgtaaat aatgagttga aaaaataatc 3180541 gtttttcctt ggtccgacag tccgtgaatg gtctgccaga atcggtgtct tgatgaagtg 3180601 tccatgccga ctgtcggttc atcaagtata agcagctccg ggttcccggc aagagccaaa 3180661 gcaaagctca aacggcgttt ttgtccgccg gataattttt ctgctcttgt tttcaaatct 3180721 tctttggtga gtgctgttaa cgaaacgagt tctttcatgg acaatggatt cggataatag 3180781 ctccggaaga gttcaaggat ttcatccacc ttaaggcccg gcatgacact tacttcctga 3180841 agcattacac ctattttttc acgaacctgt tgatcatcgg gaacccggtt aaatagtttg 3180901 atttctccct cactcggttt cagcaatcct aatatcatcg agacgacggt cgtcttccct 3180961 gccccatttg gcccgagaat ggctgcaatt tctccttttt caatactgaa gctgatgttg 3181021 tttacagcgg tttttcgctg gaaatgtttt gtcacgttgc ttactgttac tgcttctttc 3181081 atcacatgag cacctcctga tcgtttacat tgattgtaaa atgacggaga agacgatgtt 3181141 agtatggggt gtcatgatga tggagtgaca aatgtcattt ttttctcacc ccggtgtcta 3181201 ggcaatcctc ctcctgcatc ttccaattca tccatctttt ctatctccca tgtcctcttt 3181261 cttttaaact gctgtgacat tcatagaaag atacactctt caaaccatcc gagtgttatg 3181321 atagaaatat tgaactttat attactttcc ggctgaaagg agccaatcat gaacgaagcg 3181381 attttgtcta gaaatcatgt gaaggtgaaa ggcagcggca aagcatctat catgttcgca 3181441 cctggttttg gatgcgatca aagcgtgtgg aatgccgtgg cacctgcctt tgaagaagat 3181501 catcgggtga ttttatttga ttacgtcggt tcgggacatt cagatttgcg cgcatatgac 3181561 ctgaatcgtt accagacact tgacggctat gcccaggatg ttcttgatgt ttgtgaagct 3181621 ttagatctga aggaaaccgt gtttgtgggt cactccgtcg gggccttgat tgggatgctt 3181681 gcatccatcc gccgcccgga gcttttttcc catctggtga tggtggggcc ttctccttgc 3181741 tatttgaatg atccgcctga gtattacgga ggatttgaag aggagcagct ccttggcttg 3181801 ctggagatga tggagaaaaa ttatatcggc tgggcgactg tatttgcggc aaccgttctg 3181861 aatcagccag atcggcctga aattaaggaa gagcttgaaa gccgtttttg ttctactgat 3181921 cctgtcattg cccgccaatt cgcgaaagcg gcgttttttt ctgatcaccg agaggatctt 3181981 tcgaaggtaa cggttccctc tcttattctc caatgtgcag atgatatcat cgcacctgca 3182041 acagtaggta agtatatgca tcagcatctg ccttatagca gtctgaaaca aatggaggct 3182101 cgcggacatt gccctcatat gagccatcca gatgagacga tacagctgat cggcgattat 3182161 ttaaaagcac acgtgtgata taggaacgaa agggatagag gtgaccctct tagatggaca 3182221 aacaattgaa tgatgcacca tgcggtttcc tcgctttgtc agaagagggg tcgatcatag 3182281 ctgccaaccg cacccttatc aagattctgg attatgaacc ggagcaggtt atcggccagc 3182341 acatgaatat gatgttgacc attcccgcgc agcttttctg ccagctttat ttttttccgc 3182401 ttttgaaatt ggagcatcac atcgaagaaa tatacatttc cctgaaagca agagatggag 3182461 aagaaattcc cgtccttatc aatgctattg cgagacacga tagcggggct tctgtctttg 3182521 attgtgttct gattccaatg cgaaagcgaa atgaatatga aaatgagctg ctgatagcca 3182581 gaaatgaggc tcaggaagct ttgcttgcca aacagaaagc caatgcggag ttagaaattg 3182641 ccttggaaac gctgaaagca aaacaagaag aacttcttga gatcaataaa caaaatcaac 3182701 aatttaaatt aaacaccaaa agagagcttg aactcgccag aaagatccag aaaaactcgt 3182761 tgactgaacc gattgtaaac gatcaggttc agattgactc ttattacaac gcatcgagtg 3182821 aattgtcagg tgatctttac ggatattatc aaatcgatga acaccgttac ggcattatta 3182881 tccttgatgt gatggggcac ggaatttcat ctgcattgat tacgatgtct cttcatcctt 3182941 tgttccagcg ccagatcacg caaggtctca gccccgttaa agttatgaag gaattggacc 3183001 ggcaccttca cagcttgttt caaaatgatg aggaagcaag acattattgc actgctattt 3183061 atctcgagat tgatatagca cggcaaagaa ttgattatgt caacgcaggg catccgccgg 3183121 cactttggca ggacgatagc ggaactcaac atctgcttca cgcgacctcg cctccgatcg 3183181 ggatgtttga agacttagag tttcagtcaa gcagcctttc atacacggag gacggaagat 3183241 tgcttctgta tacggatggc gtgatggatc ctacggcttc atgttattta tttgatttac 3183301 taaaggatca tcctgattcg ccaatcgctg acctgaagga gaaaatcctt acatcactgc 3183361 agcatcaaaa ggaagctcat cataagagtg atgacgaatg ttttatatta gttgatgtaa 3183421 aataaaatga tccatgagac ataacaatga tttgttacat ctcatggatt tttttgtttc 3183481 agcgtttctt tggaatatgt cctgactccg catattgaaa cacctgcaag gaaggcagcg 3183541 ggtgtccatt aaaatcaaat aaagcttgat tatctacagc acttccccca taccacttcc 3183601 cggcgtcttc agggtcgtat tcagcagcat agctggacgc ccaccctgac ccgtatgttt 3183661 cccataacac tttgtttttc tctatctgtg tcttcggccc gactggaatc cacgccggct 3183721 cccagtagaa aacaccaagt cctgctttgc ccgtattcgc cactgcctcc attacatctc 3183781 ttactgcagt tgcctggcct tgaacagaaa ttggatatgg caacgtctgc ccgctttttg 3183841 gtgctgtatt tccatgccca tcgccatcct cagcggtata ggtgtacgat gtctccgcca 3183901 ccatgacttt tttgccgtac gtattggcaa cagccttcag cacggaggtc aaattttgta 3183961 atgtgccatg ccagaaagga taataggagc tagcaaacac atcataatcc actttgtttt 3184021 tgctgagtgt ttctgcaata aatgaatacc ttccagccgt ttcaggattg gtaaaatgca 3184081 gggcgaccaa aatatttgaa tttgtctccc tgaccgctcg gcttccttca ttaaataatt 3184141 ggcacatctt cgtccaatca gtctcaccgg caaatcctcc tgttgtttca tttccgacct 3184201 gaaccatgcc gatgtcaacg ccttccttga tcatcttttg caggctttgt ttcgtatact 3184261 catagagctt tgcttttttt gcttcaaagc tgagattcgc ccaggctttg ggcacctttt 3184321 gtttcgctgg atcggcccag aaatcagagt agtgaaagtc ggccagcacc ttcattccgt 3184381 tcgctgtcgc tctttttccg atttcgatgg ctttttgaac atcattgttt cccccgccat 3184441 acccgttgcc atttgaatca tacgggtgat tccagatgcg gacgcgaaca tagttgaccc 3184501 cagcctgttt taaagttgta aagatatcct ggcgttttcc gtttgtattg taaaaggtga 3184561 caccgctgtt ttccaaagca ataacgctgg atacatctgc ccctttgata aaatccttgt 3184621 tcatcccctc tactttttta acaaaaagat cctctgcccg aagctctgac acgtgcttct 3184681 ccttctcaat ggcagcggca tatcctgttg aactacatgc actccacacg atggcagccg 3184741 caaagaacat tttcactttg cttttcatga tttcatcccc ccaagactta gcaagcgttt 3184801 tcattctata gaaaaaagaa tccgcccata tcgagcggag catcagccta atgtgtgttt 3184861 acgacaattc tcacttcata cttttccatc gtcaggtcgc ctgacaatat gtctcctgtc 3184921 attatgtcct tcacactctg atcaaacgtg accagctgtt tttcttccgt gaaattcatg 3184981 acaaaaatat aatcattgtc ctgatcctgc ctcgcttgta cggagacgcc ttttccgtgc 3185041 cgaaccggaa aaactggaga gagagacagg tctgtgatca gaccctcata gaaatcacgc 3185101 tgaaattgat cctccaaacg cgcgccgata aaatacgcct tgccctgctg atactcatgg 3185161 cttgtgaccg ctggcgtgcg cgcataaaaa tcttcttgat acaccgcttc cactgaagct 3185221 gtctttacat caatcacggt tgcataatcc ttcatttcat atatttggct gcggtagctg 3185281 acagcgtttc gatccttcgg atacagggtg tccgtttcaa gaggctcaac tccaaatata 3185341 gcttgaagat ccggatgcca tccgcctgtg tatgttaagt catgctcatt cacaaccccg 3185401 ctgatatacg tcatgactaa ggtgccgccg tcagccgtaa acgcttttaa acgggaaacg 3185461 gtgtcctcgc tgattaaata cagcatcggg acgatcagca gtttatatgg tgaaaagtct 3185521 tgttctttcg tgatgacgtc gacagggata tcgtgttccc agaatgtgcg gtaatgctgc 3185581 tgaagcgttt gcggataacg ttttgtcgcc ttcgcaaacc cctgagcatc ctcgagcgcc 3185641 caatgatttt cccagtcata taaaatcgcg gtttgagccg gcctcttcgt tccgacaact 3185701 tcggacagcc gttccaatgt ctcgcctacc ttggccactt cttgaaagac gcggttcttc 3185761 gggctattgt catgatccac aaccgctccg tgtaattttt ctgatgaccc ccgtgatttg 3185821 cggtattgga aatagagaac gctgtccgag ccgtgggcaa tcatttgcat ggatgacagc 3185881 agattcatgc ccgggcgctt tgccttgttg acgttatgcc aattgaccgc gcttggcgta 3185941 cactccatta ataagaaggg ctgctgcttc aagcttcggt acagatcatt gataaagccg 3186001 accttcatcg ccaaatcagc tgtgctttcc cagtcattgt gccagacagg ataagcgtcc 3186061 cagctgatgg catcgacatg ctttgcaaat ttgctgtagt cgaggccctg atacgggatc 3186121 aaatccggtg tgtcagccat aaaattcgtt gtgataggga tatcaggcgt caattctttc 3186181 agcggaatga tttcattttc ataaaacgaa atcgtttgat cggtgacgaa ccggcgccaa 3186241 tctaaattca ggccatgcaa gccattttca ccgatcggcg aagggctttc aatttgtgac 3186301 cagtcattga acgtatggct ccaaaaaggg gtccaccacg catggttcaa tgtcttgagg 3186361 ctgttgtcat atttcgattt cagccactcc cggaaagcat gctggcataa atcacagtgg 3186421 caatctcccc cgtattcgtt tgaaatgtgc cacattaaca gcgccgggtg atgtccgtat 3186481 cgttctgcta ataagcggtt gatgtgccgt gttttttctc ggtagacttt agatgtgagg 3186541 cagtggttgt gccttccgcc gtgcagctgt ttgacgcggg aggcattgac gcgcaaaact 3186601 tccggatagg tttgcgacag ccaggccgga cgggctccgc tcggcgttgc taatatgacc 3186661 cggccgccta tactgtgaat ccgctcaaaa atatcatcca gccattcaaa ttgatatacg 3186721 ccctcctccg gctcaagtgc gctccatgca aaaatgccga cagaaaacgt attcgtatga 3186781 gaaagcttca tcagtttgat atcgtcagct aaaatatcgg gccgatccag ccactgatcg 3186841 gggttgtagt ctcccccatg gagcataaat tttgcttttg ttacgtgcgt tttttcaagc 3186901 tttgacatca cattctcctc cttgttctct tagcccttcg ttccgcctgc ggttaatccg 3186961 gacacaaaat tcttttgcag cataataaag atgacggcaa ccggtatgct gataagcagg 3187021 gctccggccg caaatgtcgt atagctggcc cccatgacat cattcactaa attgaataga 3187081 ccgacgggca atgtatatga ttcaggcgtt ctcaatatgg ttgaggacag cacaaaatct 3187141 ccgagcggac cggtaaagcc gttcatggcc acgactgccg ccatcggttt tgataatggc 3187201 agaatgatct ggaagaagat tctggtgctg ctggctccgt caatcttggc gctttcgtct 3187261 aaatccatcg gaatggaatc catgtaccct ttcatcaaat acgtattcat cgggatcagg 3187321 ccgccgatat aaagcaagat tagcagccag tggctattga tcattcccaa gatttgcgcc 3187381 agcacaaaca aggcaattaa agctgaaaac tgaggaatca tctgcagcaa taaaaagagc 3187441 gttaaagcgt atttcctccc tttaaaccga aagcgcgaaa acgcataggc cgtaaacgtc 3187501 acacagagca aagaccctgc cattgtaaac aggctgatct tcatagagtt gacataccac 3187561 tgcacatatt gaaggctttc cttgcccgca aataattcct tgtaatgatc gaatgtcgga 3187621 tgcttcggaa tgatggatgt actgattaag ctgttgccgg gattaaagct tgcgcctgcc 3187681 gtccaaagga gaggataaac aatgatgacc gccataaagg ctagcaacaa gtaagagaaa 3187741 aggagacgga tatatcttct gactttcata tctgccagca taccttatgc ctcctcttta 3187801 aaagactttg tctgtctgaa ctgccacaat gcgatggaga taacaaatac agataataaa 3187861 atggttaaag ccgcagcaag tgaatattgg ctggactgca ttgtcaattt ataaatccat 3187921 gaaacgagga tatctgtccc gccggctgtt gatccggtta cagccggacc tccgccattg 3187981 aatagataga taatattaaa gttattaaag ttaaacgtaa actgagtaat gataatcgga 3188041 gccattgcaa tgaacaccat cggaagcgtg atgtatctca gctttgaaaa gacagaagcg 3188101 ccatcaatcg tagctgcttc atacagatcg tccgggatgg attgcaatac gcctgttgag 3188161 acgagaaaga tgtacggaaa tccgagccag ccctgcatga gaatcaatgc aagcctcgac 3188221 caattggcat ctgtcatcca cggaagcgga tctatcccga agaaagccaa gatgtcgtga 3188281 ttcatcgcac cgaagctatc attaaacagt cccgcaaaaa ttaaaatcgt cacaaaaccg 3188341 ggaacggccc atggcaaaat cagaatcgtc cgaaaaaaac gtttaaaccg aaggtctttc 3188401 tggttaacaa tgatcgcgag aaaaatcccc aaggtgactt gcagtgtgga tgcagcaagt 3188461 gtccaaacca ccgtccaagc cagtacatca aaaaaagtcg acctccaaat atcaactgtg 3188521 aaaatatttg cgaacgtttg aaaaccgacc caatcaatta attttgcagg aggagaatga 3188581 tacaaatcat agtttgtaaa cgctaatgca aagctgaata agataggaaa gatcacggcg 3188641 aaaattaaaa taaacaaaga tgggccgctg acgacataag gatagccctc agaaatgata 3188701 tgctggtatt gttcctttaa ggaacttaat ggcttatttt catcacgctg ttttccgctt 3188761 tggaacgcat cgcgaagatt tacataatac accgcaaggc caaagcaggt cacgatgaca 3188821 gcaataatcc cttccgccag cagaaaaacg gaattatccc gcggcacttc tgttcccagt 3188881 gtaaagattc cccaaaaccc catattgagc agatctccaa agaccgcaaa aaacgatgcg 3188941 cctaagaaaa gaaagacaat accttttatc cattgcttgt tataaaattg cccgagtccc 3189001 ggaatgatag aaagcaacaa agcgacttga cgatgctgca ccgttttcac ctctcttaca 3189061 atacaaatct agctttctct ttattttccg ctgtgctttg ccttaatttg tcctttggcc 3189121 gtttcagctg cttgatccaa tgcttgtttc ggatctgcct tccctgttgc aaccgtctgt 3189181 aatgctgaat cagccggcgt ccatatttca ttcatttccg gaatatttgg tgttggctct 3189241 gagaaacggg attgttcagt aacagcccgt gccgcctcgc ttttcataat agccgggtca 3189301 ttggctaggg atttcacagc aggaacttct ttcgtttctt catatcgtgt tttagaattt 3189361 ttttcatttg ccaggaaaac ggctaattct tgcgccagct cttcattctt tgaaaatgca 3189421 ctgacgttgt agcttttgac gccgataaag gagctcatgt ttttcccatt ttccagcttc 3189481 ggcagtttcg taatgccata attgattcct gcattcgaaa aggcttctac attccatgga 3189541 ccagaaataa ttgcggcggc ttttccttct gtgaacagcg attccaacac gttaatccct 3189601 tgttctccaa taatgccagc cgggaacagg ccatctttgt aaaacttctg aatcagcgcc 3189661 gcacctttga cagctccttc attattgatt ccaatgtctg acgggttata gctcccatct 3189721 ttggcctttc caaaaatgta tccgccatat ccgctcatca cactttctgc ataataaatt 3189781 tgatcgaata gggctaaaaa gccaaatttg ctgccgtcag cagtcttttt ggaatagtcg 3189841 taccactctt ccagcgtttt gggcaattcc ttttctgtga tgagatcttt gttgtaaaaa 3189901 agcacagtcg tttcgaccgc ttttggcagt ccataaagct tttgatctac catttgagac 3189961 tgaatggaag cgtcagtata aagtgattga acgtcttttt tgacatgtaa ttccttgagt 3190021 aatccttccg tgacagcggt tccgatttgg tcccctggca ttgttaacac gtcagggcct 3190081 gtgccggccg gtccatccat tcgcaaatct tcaatctgct tggcatacgg tttttcaacg 3190141 actttgacct tcacatcatg ctctttttca aatgcagcca cagcgtcttt aatgccgttg 3190201 ctcttttctt tatcctccca tacaacaagc tctgaccctt ttgaactcga tttggcgctg 3190261 ctgctttcct ttgggccgca agccgccaag gataaactga cagctgcgca gagcatgaat 3190321 acggaacact tttttgccat tttcattgat tgtcaccctt tcggtaggaa tgaaagcgct 3190381 ttaaagataa tatagcatgc ctgagaaaat gtgtaaacaa actatttact tcatagagta 3190441 aattttttta cctaaataaa aaatgactta gtgtcctaag tcatccttaa ttcatactct 3190501 tcctgacgat taattctgcg cccacatata atgtttttac cgttcttctc ttgtcctgca 3190561 cttgttcaag cagtaattga acagcgtttt tacataattc atgtatatca atatgaaacg 3190621 tcgtcagagg aggcgagaca tacttcgcga agctgatgtt gttgatactc acaatgctta 3190681 ccctgtttgg tatggcaatt cctttttcgt tcagggcttg cagacagccc actgcaatcg 3190741 ggtccgctgc aatcataaaa gcagtcggaa gctgatcgcc taatgtgtcg atcgctgctg 3190801 acatcaggcg gtagccgttt tctacagaga atccgcgatg acagaaaata tagcgctcgt 3190861 ccagcatggc tttttccctc atataggatc tgaaggtttg ttcacggatg tccatttcat 3190921 cctgattggt attcggattt ttgtatgtgc cgccgataaa accgatgctc ttatgcccct 3190981 tctcagtcag gatgtttacc gtcttccttg tcatttgtgc caaatcgggc cttaccgagt 3191041 caaaatgatc gggatcagga gttgaatcga tgaacacgcc gttttcagtg agatttctga 3191101 ggaaagccag ctcttcatct gaaaatgtgc cgacggcaat aaacccttcc gtatgttcag 3191161 gaatgctctc gattccatcc gctattttat aagtggtcat atcgacattg aatgctttcg 3191221 ccagtttctc tacttctaat ctcatcgttt taaaatagac atcttctaat tcttctttat 3191281 ctgtcagcca atataaaaac gcaatatgtt tcaccagcgg ccttactgtt tttttgcggt 3191341 aattgagctt ttccgccgct tcatagattt tctcccgtgt ctcatcagga acagaaaggc 3191401 tttcatcgtt atttaaaacg cgggaaacgg ttgagattga aaatcccgct tcctgcgcga 3191461 tatctttaat tgtcgccatt gtatctgcct ccattattca gctcgcattg ttttagtaaa 3191521 atattttact ttctttttca caaatgtcaa gtgcacaaag ccctctggct gccatgtaaa 3191581 aagactgaac catttgcggc tcagtctcag ttgttcgtat cattcggaac cggcggaatt 3191641 gcccgggaaa tgagttggtt attgcacatt ttcctcgaaa tatcccgaaa gcacatcttc 3191701 cacattcgtc aaatgcgcca gcatggcggc ttccgcctgt gcaccgttcc cggcagccac 3191761 agcattgtaa atccgttcgt gctcctcata cagccgctga acggaggtct tcttggaaaa 3191821 cagccagatt ttcctcgttt ccctcattgt ttccagcagc aatgatgaca cgtgattcat 3191881 caagtgttta agaagttcat tttgagaagc gtccgcaagc gcaagatgaa atgcaaagtc 3191941 tgctttctct cccagctccc cgtccgcttc aatgctgccc atttccttta gtgcatcctg 3192001 aattctttcg agatctgctt ctgtcctttt ttcagccgct agtgaagcca cgccgatttc 3192061 aagcagtttt ctgacctcga gcagctgctt gacgtcctct tttttcatca gaagggcggc 3192121 tgagagcggc tgagaaattt gattgagctc aaattccttc agatacgtgc cttctccctg 3192181 tttcatttcg acaagcccca tcgcttttag cgcagaaagt gcttcgcgaa ccgctgaacg 3192241 gctgacttga aagctctcag caagcgcctg aacagagtcc agtttatccc ccggcttcaa 3192301 ttcgccattt ttgatcatat ctaatagggc atccgctact tcttcatata tttttttgtt 3192361 ttaatctgtt tatatttcaa tgcaattcac cccgtaactt gtaggtctgg ctgtttacga 3192421 tctattatac tctgttttgt gggccgccaa aagattttga ctattttgtc aaaaagtctt 3192481 gtactttgat ttttttcaaa atataatgct aggtaactgg tcttattacc cagtcatcag 3192541 atgatcatat catctataga aaccgcttac atatggcgcc agtttatgtt tcaaggaggg 3192601 gtttgggatg caatggacac aggcatatac gcctataggg ggaaatttgc tattatcagc 3192661 gcttgccgca cttgtaccga ttattttctt tttttgggca ctcgcgatta aacggatgaa 3192721 ggggtataca gcaggcttgg ccacattggg gatcgccctt atcattgctg tattggttta 3192781 tcgtatgccg gcggaaaaag cgctgatgtc cgcgacacaa ggagccgtat acggattgtt 3192841 gccgatcggc tggatcattg tgacgtctgt ttttttgtat aaaatcactg tgaaaacggg 3192901 acagtttgat atcattcgca gctctgttct ctcgattact gatgaccgac ggcttcaagc 3192961 tctcttgatc gctttttcat tcggggcttt tttagaaggg gcagcaggct tcggagcgcc 3193021 ggtcgccatt tctgccgcgc tgctggtcgg tctcggcttt aatcctcttt atgctgcggg 3193081 gatctgtttg atcgccaata cggcgccggt tgcctttggg gcaattggga ttccaattac 3193141 agccgtagaa gggccgacag ggattccggc gatggagatt tcgcaaatgg ttgggcggca 3193201 gctgccgttt ttatccgtat ttattcctct ttatttaatc atcatcatga gcgggttcag 3193261 gaaagccttg gagatctggc cggcgattct cgtatccggt gtttcctttg ctgttgttca 3193321 atatctcagt tccaattttt tagggcctga gctgcccgat gttttgtcag ctcttgtttc 3193381 aatggctgcg cttgctgtgt ttttgaaatg gtggaagccg aaaacaacat tccggtttgc 3193441 cggtgaacaa gagtcggccg cctcaattga aacggcgcgc acaaatccgg cggcgcctgc 3193501 atacagaggc ggacagattt ttaaggcttg gtcgccattt ctgctgctga cggcgatgat 3193561 ttccgtatgg ggcattccat ctgtcaaatc cgcgctgacc gggcattatg aaggctctgc 3193621 ggtgttcttg aagtggctga atgctgttgg agaaaaactg actttttccc ccggtgtgcc 3193681 ttttttgaac aatcagattg tcaatgctga cggtacgccg attgaagcgg tttacaagtt 3193741 ggaggtgctt ggttcggccg gcaccgcgat attgattgcc gcagtgctgt caaaattcat 3193801 cacggcgatt tcgtggaaag actggggaac cgtttttaaa gaaacagtcc aggaattgaa 3193861 gcttccgatt ttgaccattg cttctgtcgt tggttttgcc tatgtcacca actcctcggg 3193921 aatgagcacg acactcggga tgacactcgc gctgacaggt tcgatgttta ccttcttttc 3193981 gcccgttctc ggctggctcg gcgtcttcat taccggctcg gatacttctg ccaacctgct 3194041 gttcggcaac ctgcagaaag tcaccgcatt atcagtcggc atggaccccg ttctgtctgt 3194101 ggccgccaac tcttcaggcg gtgtcacagg aaaaatgatt tcaccgcagt cgatagcggt 3194161 ggcgtgcgcc gcggtaggac tcgccggaaa ggagtcagat cttttccgct ttaccattaa 3194221 acacagtctg tttttgctgc tgctcgtctg tatcatcacc tttttgcagc atcacgtatt 3194281 cagctggatg attccttaaa aaaatcctcc cgtctaggga ggattttatt tatatcgctt 3194341 tctcgctgcc gatgacggaa tattcatttg atcgcgatat tttgccacgg tgcgtctcga 3194401 gatttggatg ccgtgttgtt catacagcaa atcgacaagc ttttggtctg aaagcggttt 3194461 tgttttgtcc tcttgattga tcaggttttc cagatgcgtt ttgactgcat aattcgacgc 3194521 atctccatca cctgaagcct cggcttttgc tgagaaaaag agtttcatct caaacagccc 3194581 gtaaggcgtt tgtattgttt tccctttaat ggcccggctc acagttgatt catgaaggct 3194641 tagacagtct gccacctctc tgagagtcag cggcttcatt gcgcttcgcc ctttcagaaa 3194701 gaaatccttt tggcgtgtga tcagttcatt gataattctc gtgattgtct gttttcgctg 3194761 ccgcagcgcg cggctcagcc agcgccactc ctgatatttc gcagataaat aggagacagt 3194821 atcctgacag gagccggatg ataaaagcgt tctgtactgc ggatgcagat cgatctcggg 3194881 aaacgagcgg gtattcagtt ccgctgcgat gtgcccattt tttacggtga taaaaatgtc 3194941 aggctcaata tacacatctt gctctggccg ggcaaacaga aggccaggtc taggatgaag 3195001 agccgcgata tcatctgaga tatcttgaat ggtatgaagc ggaattcccg tctctactga 3195061 aagcgttttc catttttttt gcgcaaaagc atcaaaatga gctgaaacca gcatttccgc 3195121 ttgttcattt ctgttcggca gccgctgtaa ttgaagaagg atgcattcct gcaaagatct 3195181 cgcgccgatt ccagccggtt ctaacgactg gagttttgcc aaaacagcct ccgcttcctt 3195241 ggccgataca gataatcgcc gtgctgcctc ctctatatct tcttccaagt acccgtttga 3195301 atcaagcgaa tgaatcagat aattaaaaat ctttttttca gtgtttgtca gattcatatc 3195361 gagtgactgc tgttttaacg catcctgcaa tgttttttgc ggattactta attgaaggcc 3195421 cgcttcctgt gcattcatcc tgtttttgtt tgttttatgg taagatagtg gcggtgtgtc 3195481 tgtttccttt cgttcaataa gagggttttc cagtgagagc tcatcaatgt actcggcgag 3195541 ttctgccgaa tgatagccaa gcagcgtgat ggcctgcctg agctcctgtg tcagttgagg 3195601 ctttaatact tgtacttgct gaagtttcat atccatcttg ctcactcccc tttcttcatt 3195661 gtacatgatt gagatcacac cgtatacatt tatgaaaaag gagctgccaa agaaatgtct 3195721 gaactttttt ccgtccctta ttttattgag aatttaaaac agcatattga aatgaatcag 3195781 tctgaggata aaatccacgc gatgaacagc tactaccgtt ccgtcgtctc aacactagtg 3195841 caggaccagc tgacgaaaaa cgcagttgtc ctgaaacgga ttcagcattt agatgaagca 3195901 tacaacaaag tcaaacgtgg agaatcaaaa taaaccttcc gctcacatgt gagcaggaag 3195961 gttttccttc tttgaggcgt gctggatgag acgggtgctt ggcacgcctt ccatccaggt 3196021 atgaaagtaa ttggcgtttt tcccgtagga attatcaatg accgtgtttt ctttttgaag 3196081 aagagaagac aggatgtggc cgtgcagcct tgatgtttcc accgattcgt aacggctgaa 3196141 aaaccgaatc gctttttgga cgatataatc cgagtatttt tcccatatat acgcaatggg 3196201 caaagggttg cctgcttttt tattcaagac gttcagcgtt tggagaaaag caatcgtccg 3196261 gcggtctgaa gctgacagca ccgtgcgcca gtcgtagctt tccgcttctg cgtgttcctg 3196321 aagcgcctgg tttgcttcat gatctgttcg gataaatctc agcttttgat tggacggctg 3196381 ctgcgtggga atgacgggaa acagctgatg agccatatca ggcagaagct gaatgtgatt 3196441 tgttgtaaaa taggcctgtg ccgtagcata ggaggctttt tcccttgtca tgatgtgaag 3196501 gttcgcatgc ttagaaaata tctctgccgt ccgcttgagg ttgtctttgt tttgaaaata 3196561 aatcgattgc ggcaggatca caattttgtg gttcggatag gtttggacga ttttctctct 3196621 aaagccttga taatacggat acagatcccc gaagtttccg cctccctggc agacgatgat 3196681 gagattcgga tcaagctttc gcccgattgg gaaattgtct ggattccagc gttttctgac 3196741 ccgaatcccg tgttctttaa agaaggcttc tgttcctttc ataataaata aatcccctac 3196801 attcccatat agaggatagt cagcatatat aatctctgat tgtttcggaa tgacgtcgag 3196861 cagcccggac agtttctgtt tcaggctgat catcgaatgc ttgctgtcca tttcttcacc 3196921 tcgacagtat ggaataagtg cagtagcact tcaatgaccc ggccttgctc atcttctgtc 3196981 atattggacc ccgatgggag acagattcct cgcttgaaca aatcttcgca tacgcttcct 3197041 gtatcttcat gagaataaaa taaagccgga tcgaacagcg gctgggtatg gagcggcttc 3197101 cacagcggac gggcttcaat gttttcttca gcaagacgtt gaactatgtc atatgggctg 3197161 agcccgttat caagtgtgag cgtggtgagc cagcgattgg atacgcctgc tgcgtactct 3197221 ggcataaagc ggacgccgtc taagtgaccg agcgcatttt tgtatctcgt gaaaatggtc 3197281 cttcttttct ccactcgctc atccagcacc tcaagctggg caatgccgac gccggctaag 3197341 atattgctca gcctgtaatt atgtccaatt tcactgtgct gataatgaac agccggctct 3197401 cgtgcctgcg aagcgagaaa tcttgctttt tcaattgcgg cttcatcatt tgaaacgagc 3197461 atccctcccc ctgatgtggt gatgattttg ttcccgttaa atgaaaaaat gccgaagcgc 3197521 ccgaatgttc cgctttgctt ccctttatag actgtgccga gagattcggc tgcgtcctca 3197581 atgacaggaa ctccgtatgc atcacacagg cttacgattt catccatttt cgcgctctgc 3197641 ccatatagat tgacggcaat taccgctttt ggcagtgttc cgtttctttt cgcttcctcc 3197701 aatgctcttt caagggctgt cggcgacata ttccacgtat caggctcaga atcaataaag 3197761 acgggcaccg ctttttcata tagaatcgga ttggcggttg ctacaaatgt gaaggactgg 3197821 caaaacacgc tgtcaccttc ttttacctca agcaaacgca gcgcgagatg aatcgccgcc 3197881 gttcctgagc cgaccgcagc tgctgctttt acaccgactc gttctgccag ctgttcttca 3197941 aatgaattca cgagcggccc aagcggcgca atccagtttg agcgaaaggc ttctgaaata 3198001 tagtgctgct ccctgccgct catatgaggg ggagataagt agattttttt atgcatagaa 3198061 tcatcctttg tttgatgttt gaatggaaga aatgatgcgt gccggagcac cggccgccgt 3198121 taccctgtcc ggtatggaac ggatcaccgc ggagccggct ccgacaatgc tccaagcccc 3198181 gattatgatc tgcggtatga cggatgcacc ggttccgacg tgagcgcctt cctgaacgga 3198241 aaccgctcct gacagcgtgg cacgcgggga cagatgaacg taatcgctga tttgattgtc 3198301 gtgctctgcc actgcacccg tattgatgat gcagtgggcg ccgatgcgcg catccgcctg 3198361 aatgatcgcg cccgccataa tcactgtccc ttccccaatg acagccgact tgctgacgat 3198421 ggctgacggg tgaatcaatg taataaaatc atctttcccc agtcccagtc gctccgccag 3198481 ctgttttctg acactgttat tcccaacagc aatcagaaac agcacatcag gaatgagcct 3198541 gcgcagttca gtaacggctt tcggcggtcc tgtgtaccat tcttttccgc cttcgaacgt 3198601 tttgaattta tcatccagca ccgcggctaa gcgcgtatct gagcgggcgt ttatcagctc 3198661 tctgatcacc tttccgtgac cgccgtcacc cacaatggcc acatttttca tgaggacaca 3198721 tctccgcttc cggtaaaccg ttccgcggtc acatgattgg tttgctgaat cccttctgaa 3198781 acaaggacct ttcgcaccgt caaacataaa attttcaaat cgagaaaaaa tgaccagttg 3198841 tcaacgtacc aaacatctaa ttcaaatttc ttttcccagg aaatcgcgtt tctgccattg 3198901 atttgcgccc agcctgtgat acccggcttc acctcatggc gccgtgcctg tttttctgta 3198961 taaagaggca gatagtccat caaaagcggc cgcggcccga caaggctcag atcgcccttc 3199021 aggacattca ggagctgcgg aagctcatca atgctcagct ttctgatcag cctgcccgtt 3199081 ttcgtcagcc ggacttcatc aggcagcaga tttcctttac tgtcccgttc atccgtcatt 3199141 gtccggaact tatatagggt gaacggtttg ccgtgcaggc ccggccttac ttgcttaaag 3199201 aagacaggtg atcctatttt cagcctgaca acggcgatgg tgaacagaat gatcacactt 3199261 gtacagcaca acaaaaaaat ggcggccgtc agatcaaaaa gtcgtttcag gatcaaagat 3199321 tcacagctcc tttcgttttt cgaaaccgtt ttaataccag ctgtctttcc tcttttgtac 3199381 aaacgagcat aaaagcgaaa acagcgtagc aaaagctgac tgtcactccc gtcgctatca 3199441 atgacggcca gctgtcaatc ttcacaatga actgaattgc cttacagacc gtccaggcaa 3199501 atacagcggc tgaaagaggc ccgattatgc ctttaaggaa cacgtgcttt ttgtagcctg 3199561 taatgcggga tacgtaaagc ggcgtaaaga tggcattttt taaaataaga gaaatggccc 3199621 ctgccaatgt tatgccgtac agaccgagat gagccggccc gctcagcgtg accgccagca 3199681 ccacattcac cgcacctaac agcagggtaa caatcgccgg tgttttttgt tgattaaaag 3199741 cggtccatat ataaaacagc ggcataaagg cgaggctgac aaccaagtat ccggcatgaa 3199801 taaataaaag cggtgctatc gttgaaaagg acggtccgag ccagattgtc agaaaaggtc 3199861 ccgccaatcc gcccaataag gcagcaggaa gtgcaagcaa aagaccattg agccttactg 3199921 ccttattggc gtaattcatc aatccttcca tatcgccttt tgaataatat gaagtcatga 3199981 tgggcgcaaa cagggatgcg accgttccgg ccaagctgcg caaaagcagc ggaaactgga 3200041 taatcgccgc gtatttcccg gatgcagacg cccccagcat caaattggcg gttaacagat 3200101 caatctgcaa aaaaagcagg acgccgattt gattgacgga gctccatgcg cccgcttgaa 3200161 acagctcctt gcttgtacgg aatgaaagat ccttcatacg aaacgaaaac cacggaatca 3200221 gctttttgaa gaaatagaaa gacagcacag acgcaataac agcaccagct aaagctgcaa 3200281 gctggatctg ccagattttc ggcgcaaagc atgcaaacag gagcagcaca gacagcaccc 3200341 gtataagcat ttgcaccgcc tgaatggaac tggtgatata aaggcggttg gcataaaatg 3200401 gtgcagcgcc gaagcccgcc atcagaaacg ttaaaataaa cagcacactg ccgattaaaa 3200461 tcgacaaacg cacatctgcc aaaagcgctt gcggcacatt catgacgcgg tcaataaaaa 3200521 aagccgaacc cgcaagcggc agcaagagca gcaaggaaat caaaacagag gcggctaaat 3200581 aattgctgat atacgcattt gctttctccc gctctcccct gtgggcagca acagaaaaga 3200641 accgaacgac aaccgagctg agcgccacgg taataaccga aaagtaatta atcacatttt 3200701 gtgtcaagtg aacaaagcca aacgcttcga caccgagcgt tttgacaata aaaggcgtca 3200761 tccaaaccga taggaaaaca gacaagagaa aagccgtgag attcgcgctg aaatttatcg 3200821 tgaatttcat gcctgcttcg cactgccttt cattgtcccc cgctgctcga aaaacagctt 3200881 gatgagaaaa gtgagccgcc atttacacag tgctaatacc aaacgctctc ctcttaataa 3200941 tttctcatgc tgaaacggtg tatgtctgac agcctgccgc accatgtcat aggataaaat 3201001 ctgtctgatc ttctttttga tgtctttcgg cgaattcgga gaagcacagg catttgccaa 3201061 aagcatcgga agctggtgcc tgcaaatgta cacattcaaa tcttctttac atgcgcctgc 3201121 taagccgtag tgattgtaga atgcgatttt agcctgatat tgtttttgaa gatgttcatc 3201181 catcgccggc ttataaggga tttctgtcag gctgttcggg ttttcacgat aaatgtacaa 3201241 tccttcatca agcattttca cccgctccgc ttcgcgaaaa gcggacaaat taaagggaga 3201301 gtcttcagca aaacggatgt cttcatcaaa cagcagattc gccctttcaa aaagctcacg 3201361 acggtaaaga taacgccata cataccagat aaatctcgtt tcgtgagcat gtttaagctg 3201421 ttcagtcatt tctggtttcg tcagcacgcg gtttgcctca agctgcggcg gcacatatgt 3201481 ccgcctgtcc gatgactgct tgtaaaaacc gcatccgacg atgtcaagct gattttgctc 3201541 cgcttcttca gtcagcctct ggaacatggc ggatgataca taatcgtctc cgtctacaaa 3201601 gccgatgtaa gtgccccgcg cggcctttat tcccgtattt cgcgctgaac taagcccgcc 3201661 gtttgcctga tgaatgaccc ggattctcgc atcccgtttt gcatagtcct ctgcaatttc 3201721 gcctgaacga tccggtgttc cgtcattcac gaggatgatt tcaatatcag aaagcgtttg 3201781 acgaagcaaa gaatcaatgc actcttctat aaatggttca acattataca tcgggacaat 3201841 aatgctgacg agcgggatca ttgcgcttca ccgctgattt tgtcacgcag acctttaaaa 3201901 tacacatctc tcggaaagcc tgcacgggat gtttcttttg ttaaaagctc attgactgcg 3201961 gctgttacgc gctctggctc cggatgttct atcagcttca tgaacgggat gtctttaagc 3202021 cattgatagc cctccatcac cttatggtca aaggagcgaa tgacaacaca cggcgttcct 3202081 gtcagcgcgc aaaaaatcat gccatgaagc ctgtcagtga cgacggcttc tgcgctttgc 3202141 agcttagacc acagtgcttc aagttcatgt tcgcgtgtat cgcggctgac ccggcggccg 3202201 atcgttgtcg taaaggattt gatctcgccg aattcctcac atagcgcagc cttgacccgg 3202261 ttcctctgct cctcctgaag cacgctttcc tgatcctcgc gcaaacacat ataaacccct 3202321 tcgcgttctg cgggagcctt gcttctgtct aaatacagca ccatgtccgg ctgcttcaaa 3202381 attgtttttt cttgaaaatg ctgtttcata aattgatacg ttgtttcatc ccgcgccatc 3202441 agcaataggc cggggtgcgc attataaatt ttctgtgccc gtttcagctc tttgcgccct 3202501 tttttcgtgt cagaaaaatg agccgttgcc ggaagctgga caacccgata gtcatggaat 3202561 gttttaatga tgaagcggcg cgtccactcc tcataacggt ataaatcccc catgtttccg 3202621 ccgccgatga taaagaccat atcctccgga tggcgcgagc ggatcaggct ttttgctgat 3202681 ttgtaaatgt ccttcatatc gacctcgacg atgtcaaagt ccgggtattc ttgctcaaga 3202741 aatgccttgc tggcataagc aattgcgtga tctcccaaat tgtcatggga cggcagcagg 3202801 gtcagtatga tttttttctg atgtgctgcg gcctttaccg gttgatctgc cgctcccagc 3202861 caatattggg acgggtattt gacctttagc agcagccatt ctgcaaaatt gattttcaac 3202921 gattgtaacg acatgtcctc accctctgtt tctcattttg tactcgatca cccgctgata 3202981 cacagccgat gccatagcga cgaacggaat cattctgtat ttcgccatca gaagcaggca 3203041 tgaccgtttt gcgtcaaaag gagcagtacc cgtttttgaa agactttctt gaaacaccgg 3203101 gtccgcgcat atcacgccaa catttctaag cttttcaaac agccggcggc tgccgctcgt 3203161 tttccattca ttcagcatac agatgctgct gtgaagaacg ataaaggtat caagctcctt 3203221 gcgatactcc tccagtttgt tgttctcctg taaaaacgcc gcattcgtct catacagcgc 3203281 aagtcctgat tcaaacaatt ttttctgata gcgctgcaca atggaggaaa ggtgaattcg 3203341 ataatgatag agcggcgttt ttacgtagga tactgagcgg gcgaaaaaat gagccctgaa 3203401 gctgaaaaac tgatcctcga catgctccag ctcgcctcgg agcggaaacg acagccgatg 3203461 ggcttcaatc atgcttcttc tgtacagttt gttccatgaa aaccctctga ccttcccttc 3203521 gaataacgcc ttgatatagt gctccttcgg ctgatcctga taggtttggg caatgtcaga 3203581 gtccatggtt ttgccagtgt cctcaaactc tgcggcgtaa ttgcaaatga ccagatcagt 3203641 ttcatcgcct gctgtccgga gcatctgctc gcaataatca ggctcaatcc aatcgtctga 3203701 atcgataaac gcgataaatt cgccgcgtgc agcttcaatg cctttattcc gaaccgcacc 3203761 gagtccctgg ttttcctgat gaatcacctt gaacctgttg tccattttgg cgtattcttc 3203821 tgcgatatcc gggctggcgt cagctgaacc gtcattgaca atgatgattt caatattgtc 3203881 cattgtctgg ttccgcagtg attcgagaca cgttctgata tatgtttctg tgttataaac 3203941 agcgactaac agactaaccg caggtgtttc cataatgacc ggctcctcgt gcataaatta 3204001 ccgggaaaaa atcgttctgt aaggcagaac cgatgaatcg accggcataa gcaaataact 3204061 gtaaagaaaa taacaaacaa cgatagcgat atagataaga gcgttcgatt tttcatcaaa 3204121 tatcctgacg aaataaggga ctaggatcat ttgatacaga ccgaaataaa tattgaatct 3204181 ggcaaaaatc acgtcctttg tggccaaaag gccgaacaaa aaacctagca ggcacaaatt 3204241 gacgacaata tcaatttgcg gccacagact ccgcagtcgt tctttatagc aaaatgcaag 3204301 gaacagcggc agaaccaaaa cagcgatttt gatcacattc attccatttg tgttcgtcat 3204361 gagccatttt tcataatggc tgtatgagct gttttcaagt acaacgacaa acacagaaat 3204421 aaatttttga tataaaaatg tcatgccgag aaataaagcg gataggccga atatcgccgg 3204481 tgaccaggct tttcttctga caataaagta cactggaatc ataatcagcg ccgacgaatg 3204541 aaagagcgag ctgaccagca caatcaggaa atatcgcttc cagttcccgc taatgatata 3204601 acggatcgcc caaaacaaaa cagctgccac catgtattgc ctgatgccgt taaaagatgc 3204661 gtaataatga aaggttccca aaaataaaaa gacactcagc tcaaacggcc tgccatagtc 3204721 ggcgagtgtc ttcataataa agctgtaggt cacgaccgcc accgtaaaat acatgatttg 3204781 aggatcttcc gtgatgaaat tcatcagcca aaggagtgcg gtaaaccccg gatctgtcgc 3204841 tgttttcgct gtgccgaaac cgaatatctg ccacacattt tgataatcgc ccgccaattc 3204901 gtacaacagc gtgtacgtct gaaaatccgt gccgactcga tagcggagac ctgacacgag 3204961 cacaagtgaa gcgagcggaa tccagatcaa aagcttattc ggccgatacc ccgtggcaag 3205021 cgaatcatca cggccgccgc acattttagc gaaccaagac caaataaata caatccccat 3205081 attgacggca tatacaatca tcggttatgg tccttttccg tgctgatgtt gtatacattc 3205141 agcagcgctc ctacattttg ctgtgcatcg tagccaagtt gagcgagtgt ttctttgatg 3205201 aactcacgct tcggcctgcc tgcggcggcc gcccttgcaa tggtttcagc ccagacgctg 3205261 atcggctcag aaagacttaa tcttgtgaca agcccgagac cggcgtcgac tttttctgta 3205321 atgctgtctg aaatgatgca tggaagcccc gacgcctgcg cttccacaag cacaaccggc 3205381 aagccttcgt acagagacgg catgacaaat acatcgaatg ttcgcatcag ttcatggatc 3205441 cgttcttccg tgcctaaaaa gaggacgtct gatagcaaat tctgctgccg cgcctcctcc 3205501 tctatctccc cgcacaacgg cccgtctccc gccagaacga gctgaaagcg aatgcctctt 3205561 tccttgagat gtgcggcaag cttcaacagg aacgcgtggt ttttcacttc atgaaaccgg 3205621 gccacatggc caatgatgag ccggtcggct gcaatgccgc gtgctgcttt ttcttcatca 3205681 gccgcctgcc catttggggc gaacaactca aggtcaatcc cgttaggaag aaggtgaaca 3205741 cgctcccgct ccatattgga ctgtccaaat aaaaacctgc ccgcatcctc tccgcaggca 3205801 cacagcgctg tcgcatttgc caaaatgagc cgcctgaaca cgagcagctg caatcgatcc 3205861 ttccagttga agccggtctt ccaagacgta ttgtgggagt ggcataccct gaccggcact 3205921 ccggcgagcc ttgccgcaag ggcgataaaa cccgtttgga aatccgtgtg cgcatgaacg 3205981 gcgctgaacg gcccattttc ttttatcgcg tttctcacat tcctcacaaa tgtaagggga 3206041 ttgctttgcc caatgctcgg gacataaaaa agccgcccgc ctaaagataa aatctcttca 3206101 tcataagcgc acggatcatt tcgatacgtt aaaaaatcaa attgcacttt gcttttgtcc 3206161 atcttccgat ataaattcat taccatggtt tccgcgccgc ccctgttcat gccgctgaga 3206221 acatggagca cgcgcttttg gctgctattc atgcttgaca agcccttcct tttggttcat 3206281 cactcttttt ttatggtagc gattcatcac agctgcaggc ataaaggcgc gaattaacgg 3206341 ttttgcgata tatatgtaat cagataaagg aagcttcaag cgtctgcacg cctgatagac 3206401 aagaatggca ttgtcgattg aatacgtaaa tgaccgccgt ttgaatgcat cgctgtcttc 3206461 cctcacttta tacaaggctt cctgaagatt atagcccctg aagccctctt caaaaaagcg 3206521 aagccacaaa tcaatatctt ccattcgtct cgtccgccgc accgaccggt agcctttcag 3206581 cgtgcggtag gcactcgctc tcatcataat cgtgccgtgg caaaatggag tcccttttgc 3206641 catgatgccc ggctccggaa cagaaggcag aatgcgggcg cctcttacgc caaattcatc 3206701 aaacacaagc atgccggtgc caaccacctg atagtgtcgg tgcttttcta aaaacgcgac 3206761 ctgcttttcc agacggcgcg gaaacgaaag gtcatctccg tcctgacgtg cgatataatc 3206821 gcctgtcgca tgcgaaagac aatgatttaa tgatgcggca agccgcttat ttgttttgtt 3206881 ttgaatcagt ttgatgcggt cgctgtaatg agcggcatac tgcttcgcga tacggagcgt 3206941 gccgtctgtt gacgcatcat cgcacaaaat cagctcccaa tttttatagg attggctgag 3207001 tatggattct atgctttctg ccaaagtgcg ttcgcaatta taaatgccca taatgacaga 3207061 aactttcggt cctgagttca tacgcttttc tcctttgtat ccatatccat gtacgcggaa 3207121 taaatatctg ccatttcttc caccgttcgc gcctccgaga agcgcaaggc tgtttttcgg 3207181 ccttcctgtc ccagctttcg gcagagctcc ggcttatggt aaagctgttc aatccggcgg 3207241 gcaaaagcag cactgtcacc gattttgatc agaaaaccgt tttctccgtc gcggatgatt 3207301 tcccgatgcc cgcgattatc tgtggcgatc gccggttgtt ctgccgccat tccctcaagc 3207361 acattcatac cgaggccttc tctaatgctg gatgcgacag atacatccgc aagctgaatc 3207421 aactcatgta tgtcgctgca aaagccgtaa aaacagacat gggcggaggc accaagcttt 3207481 tcagctaacg tttgatacgt atgttccatt gccccttccc cggcaaacac aaggcggagt 3207541 gagggaattt tttcttttag caaggctgcg gcttcaatta actgcttctg gtttttgttc 3207601 agattgagct cagccggata aaccaatata aaatcatctt cacggaaccc gtgcttttct 3207661 ctgagtcttt gctgctctat cggactgaca ggccggaaac gctcggtatt gacgccaatg 3207721 ccgtgaattt tctgcgtcct tccgcccggc ctttgaagtc ctttcgcccg tatgtaatcc 3207781 tcttcattaa tcgtaatcag gcagtctgta tatgctgaaa gccatttctc aaccggatag 3207841 taaagaagcc aatttttcat cggtgcccct ttgcagaagt gaaatccgtg cgctgtgtac 3207901 agcacctttg ttccgtgccg ccgtgcctgc ctcgccgcca gtctggcgag aacgccgccg 3207961 accggtgtat ggcaatggac aatgtcgtat tcataagtgt caatcacttt cttcagctgc 3208021 ctataaacgg ccaggttctg agggtcaaaa ggtgacctgc gaatcgggat ggagaatttc 3208081 tcatccacat acggcagctt ggtttgtccg ttcgcggcga catgaacctc ccagcccatt 3208141 tgcttgaacc atttaaaata agggaggtga aaggccttaa aatgataatc aacagtcgcg 3208201 caaaacaata tctttttcgt cattttcact ccccctaatg aacgctggca gccgtcattt 3208261 cttctgatgt attgattgcc gcaaacagcc tcgctctcag gtcggcttcc ggcagctcat 3208321 gaaaatcctc gataaagcgc atcagcaccg gccaatcgcc gtccaccgct ttaccgatgt 3208381 gaatttttgg aaagatttgt tcagcatgga cttcattttt gttcagcaat tcttcataca 3208441 ttttttcgcc cggacgaatg cctgtgaatt cgattggaac ctgctcagtc gtgtagccgg 3208501 acaaatgaat gaggtttttg gcaagatcca caatctttac gggctctccc atatcgagaa 3208561 cgaaaatttg acgccctttc gccagtgccc cagcctgaat cacaagcctt gatgcctcgg 3208621 gaatcgtcat gaaatagcgg gtcattgccg gatgtgttac tgtcaccggg ccgccttttt 3208681 caatctgttt tttgaaaatt ggaatgacgc tgccgcggct cccgagtaca ttgccgaagc 3208741 gaacagcaac aaatttggtt ctgctgactt tcccaagatt cataataatc atctctgcga 3208801 atcgttttgt cgcccccatt acgttggctg ggttcaccgc tttgtccgat gaaatcagca 3208861 cgaatgtctc agttcccgac atatcggctg cttccgcgac attttttgtt ccgataatat 3208921 tgtttttgac cgcctcttct ggattgtgtt ccattaaagg cacatgctta tgggcagctg 3208981 catgatagac aacatgcggc tcgtattttt tcatcaaggt aaacatttta tcgcggtcct 3209041 gcacatcagc gatttccgta tggaacacaa tgtgtttgcc gaatcgtccg ttcagctctg 3209101 tataaatcga atgaatgctg ttttccccat ggccgagcag aatgatttcc ttaggctgaa 3209161 acgcgctgat ctgacggcag atttccgagc cgattgatcc gcccgctccc gtgacgagaa 3209221 ctgtttttcc tttgatgcgg ttcgaaattt cgctagtgtc gagggttacc ggctttctgc 3209281 cgagcaagtc ctcagctttt acatctctga tttgtccggc agttcgtgtg ccaagcagca 3209341 tttcatcaaa atgaggcata attttaatgc ttactccggt tcgcacacat tctttatata 3209401 acacctgaag ctcatgggtg cggagtgaag gaatggcaat aataatataa ttaattttga 3209461 gcttttgcac cgcaggcatg atactttctt ttccgccgat tacgggcagc cccataattt 3209521 ctaatttatg cttcgtttgg tcgtcatcaa taaaagcgac aggtatgata tcaggttcat 3209581 ctttcgaaag cagctgcctg accatcagag tcccacctga gcccgccccg ataatcagcg 3209641 cgcgggacga ggcgcagcgt tttttcctga tgctttcgtt taatactctg gataaaatac 3209701 gggtccctcc aatagacaaa agctgaagca cccagcacgc ggttaacaga cggaagaaca 3209761 tcgtgtgata cacagcatac tgaatgacgc cggtcacagc ggctgaaagc gtaatgccct 3209821 taagcaggac aatcagctcg ccaagcccgg tgtatgtcca cacctgttta tactgattga 3209881 acaggaaagc acacacatga tagctgagga gcaagctgac agcggtaagc agtaatgctc 3209941 cggagtcata aaattgatag gaatctttta aaaattgata tcctgcaata actgaattta 3210001 aaacgaggta agtatccagc gcaataatca ttgacagtct tctccggtaa ctcaaccttt 3210061 tcccccctaa ttcttttatc ggtttagctg cggcggtttt cgtctctcca aaaaatcggc 3210121 agcagctaaa ccgacaatac gtcctatgta tatatgagat aagtgggcat ttaacccatc 3210181 ctcacgcccc gccagcgacg accagcatct aaggcagcaa cttcagctgc ccacagcaga 3210241 gccgagtgcc tccattgata caggtcagga gacatcacct ttacaaaaac tagtaggaat 3210301 agtgttccga ttttttcatt ttctttttgt ttaaaagagc gcctaacagc ttcgcattgg 3210361 attgttccag tgcatctttt gctttcagaa cggtatcggt ttttgttttt ccgcttaaaa 3210421 cgacgagcac gctgccgtct gtctgatttg ctagaatctg agcatctgca acagccaaaa 3210481 gaggagggga atcaaagatg acgaggctga attgttcata gatctcagat attaaatctc 3210541 ccattgcttt tgaagacaac agttctgccg ggtttggcgg ggtcggcccg cttgtcagta 3210601 catataagtt atcgatcggc gtcttttgca ccgtctcact gagtgaagca ttgccgacca 3210661 gcacatttgt cagcccggtt acattatcaa cctgaaacgt ctgattgatg gtcggctttc 3210721 ttaaatcggc atccaccagc agtactttct tttcctgctg ctgcgcaaag acagccgcaa 3210781 gattcgctgc actgaacgat ttaccttcac caggcacaga ggaggtgacg aggatagatc 3210841 gcaagttggt ctggacagat gagaactcaa tgtttgtccg aatggtgcga tattgttccg 3210901 caacaactga tttattgtgt aaaacagata tttgagccaa acctcgcctt gctttctttt 3210961 ttctaaagat cactcgcttc actccccgaa atgttttatc ccgcgattcc gccctttgtg 3211021 gacatcagga acggagccta agcatggcaa tccggttctc tcgctgagct gccgtgcgct 3211081 tttgcatgta tcatcgagaa aatgcagaaa aaatgccagt gtaatgccgc ccatgacagc 3211141 agcgccaaaa gccatgacca tatttcgcag cctggccggc ttgatcatcg ggctttccga 3211201 agccttcgcc tctgataata tatgtacgcc ttgtacattc attctttcat ctacttcttt 3211261 ttcaaacttg ttcactaacg tgttcgcaat ctcagctgct ttcgccggat cgtgatcctg 3211321 aacggcaacg ttgattattt ctgattcatt ttcactgctg gtaaccactt ttcctttcag 3211381 cgaggaagcc gattcagata ggtgcaattc cgccttaact tcttccatca aggcagtgct 3211441 tttcataatc gattggaacg tgctgctata ctgaagattt cgctggatgt cactgagatt 3211501 cgagttttct tcaccgtctg attcatgaac cagcacctgt gtcgacgcct ggtaggtcgg 3211561 tgaaatgacc ttaaattgca caaaacccat aataagggtg acgccgattg tgatgagcag 3211621 aatcagcacg aatctgtgtc tgacaatcgc atataattct ttgaaactca tattctcatt 3211681 catgtattca tagccttcag ccttcccgcg gctggcttcc cgcgcccctt tctgttaatg 3211741 attggattat aaaagaaaac gttattattt aaaaattgca aaataagcca ataagttctc 3211801 tttagagaac aaaatcatga ttttcctcta atttactgca cttcccttat tattttaaat 3211861 tttataaaga acgaaaaatt ccttataatg aacgaaataa cgacaggaat agaggagaat 3211921 ttcatattat gattggaaga attatccgtt tgtaccgtaa aagaaaaggc tattctatta 3211981 atcagctggc tgttgagtca ggcgtatcca aatcctattt aagcaagatt gaaagaggcg 3212041 ttcacacgaa tccgtccgtt caatttttaa aaaaagtttc tgccacactg gaagttgaat 3212101 taacagaatt atttgacgca gaaacaatga tgtatgaaaa aatcagcggc ggtgaagaag 3212161 aatggcgcgt acatttagtg caagccgtac aagccgggat ggaaaaggaa gaattgttca 3212221 cttttacgaa cagactcaag aaagaacagc ctgaaactgc ctcttaccgc aaccgcaaac 3212281 tgacggaatc caatatagaa gaatggaaag cgctgatggc ggaggcaaga gaaatcggct 3212341 tgtctgtcca tgaagtcaaa tcctttttaa aaacaaaggg aagatgatga tcggttaaag 3212401 ggctaacgtt cgcatctata ggggaaatct gtttataatg ggggaaaaag ggagagaaca 3212461 caatgactca tcaaatagta acgactcaat acggcaaagt aaaaggcaca acggaaaacg 3212521 gcgtacataa gtggaaaggc atcccctatg ccaagccgcc tgtcggacaa tggcgtttta 3212581 aagcacctga gccgcctgaa gtgtgggaag atgtgcttga tgccacagcg tacggctcta 3212641 tttgcccgca gccgtctgat ttgctgtcac tttcgtatac tgagctgccc cgccagtccg 3212701 aggattgctt gtatgtcaat gtatttgcgc ctgacacccc aagtaaaaat cttcctgtca 3212761 tggtgtggat tcacggaggc gctttttatc taggagcggg cagtgagcca ttgtatgacg 3212821 gatcaaaact tgcggcacag ggagaagtca ttgtcgttac attgaactat cggctggggc 3212881 cgtttggctt tttgcacttg tcttcattta atgaggcgta ttctgataac cttgggcttt 3212941 tagaccaagc cgccgcgctg aaatgggtgc gagagaatat ttcagcgttt ggcggtgatc 3213001 ccgataacgt aacagtattt ggagaatccg ccggcgggat gagcattgcc gcgctgcttg 3213061 ctatgcctgc ggcaaaaggc ctgttccaga aagcaatcat ggaaagcggc gcttctcgaa 3213121 cgatgacgaa agaacaagcg gcgagcacct cggcagcctt tttacaggtc cttgggatta 3213181 acgagggcca actggataaa ttgcatacgg tttctgcgga agatttgcta aaagcggctg 3213241 atcagcttcg gattgcagaa aaagaaaata tctttcagct gttcttccag cccgcccttg 3213301 atccgaaaac gctgcctgaa gaaccagaaa aagcgatcgc agaaggggct gcttccggta 3213361 ttccgctatt aattggaaca acccgtgatg aaggatattt atttttcacc ccggattcag 3213421 acgttcattc tcaggaaacg cttgatgcag cgctcgagta tttactaggg aagccgctgg 3213481 cagagaaagt tgccgatttg tatccgcgtt ctctggaaag ccaaattcat atgatgactg 3213541 atttattatt ttggcgccct gccgtcgcct atgcatccgc acagtctcat tacgcccctg 3213601 tctggatgta caggttcgat tggcacccga agaagccgcc gtacaataaa gcgtttcacg 3213661 cattagagct tccttttgtc tttggaaatc tggacggatt ggaacgaatg gcaaaagcgg 3213721 agattacgga tgaggtgaaa cagctttctc acacgataca atcagcgtgg atcacgttcg 3213781 ccaaaacagg aaacccaagc accgaagctg tgaattggcc tgcgtatcat gaagaaacga 3213841 gagagacgct gattttagac tcagagatta cgatcgaaaa cgatcccgaa tctgaaaaaa 3213901 ggcagaagct attcccttca aaaggagaat aaatatgggg aaaacaggat acattggtgc 3213961 tgccattgtt gtggcagctt gtatcattat tttgtcggcc gtggtatgtt tacgggacac 3214021 agtctattac cagcctatgc gctggactgg catcatactg tttttcgcgg gaattgtgat 3214081 ggttcccgca tactcagcaa aaagaaaacc cggaaaagag aagtaattct cttttccggg 3214141 tttttatgtt tattataatc ttcccgcgcg aatatcgtct gtcattccct cataaggagc 3214201 cttcgaaatc acttcttcgt tgtcgactcc ttcatttttc agaaatgtaa tttccgcaaa 3214261 ttcaggtaca acgtattttg gatacgtttc atatttttcg cgggattctt tcatcaaatc 3214321 aatgtggtca ttttggtagc aaaccgtaat ttcaggatgt tcatgcaccc atttcgggaa 3214381 gaaaataatg ccatgcatgc gtttttcatt tggcataaag tttaatgaaa catccgtgcc 3214441 agtcggctct gtccaagaca ctttatatac gccttctgtc agtttgacaa tattcacttc 3214501 ctgatctcga acccagcgtc cggcaaccat tccgctatga attctataat caattgtatg 3214561 gtcgttttta atataaatct cgtattccca tccgttttca tacgtataaa tcatgtggct 3214621 tccgataaag ttttccatct tacacactct ccttagtctt ttactgtact tcataaatgt 3214681 ctagtagaac gtaatcaggg gttctttctg cggaaccgat aaacaagcgg tcatggagcc 3214741 attgatagac ttcactgcct gtttcaaacg tcggtaccgt acgaaaataa acatgctccg 3214801 gttcaataat ttccccggct gccgcttgtt ttcgaaacgg cttgctgact tgccgtattc 3214861 cattgttttc aatgtaaatc agttcatgat ctgctgtttc aatcacatac ctggcagata 3214921 aatctgttct gccgttagcg cgaatcattt gtgaatcggc accgcccggc aaaatacgtc 3214981 cctttacttc cccggttatt gttcccgaac gaatcggaat gaatcatctc agtcccaggc 3215041 ttgtctcacc aatcgtgata ggcggatcaa ccttgatttc taaagaggcg aatggtttta 3215101 aaaccggctt cttcacgaga accacctcac cttcagaaaa aatcatgtaa ctatttacat 3215161 gttcacttta acaccattgc agttaactgt caaacaatag gaacataaaa aaacaaggac 3215221 tgtttgaaga cagtccttgt ctgaagctag ctttgataag caagatatgt gctgacagtg 3215281 cttttggcaa gacaggcaga ggaatctata atcggaatct cactttgaat atgatctaac 3215341 accgcattta aatccgtgca ggctgaaatg atgatgtctg catgctgact gatttcttca 3215401 tatagcgtct gccacaatgc ttgtgtatgc tgcatatgat ttggctgttt gattgcggcg 3215461 ataagctggt tcacagcctg ctgccaatgg tccttgtgaa taacttcttg tccatttccc 3215521 ttcagaactt tttggtagat ggcggattgg atggttggct ctgttcctaa aaccaccgct 3215581 ttttttgcgg gatgcggaat ctcttttatc gtttcctcaa caatatgcaa cataggaact 3215641 gacaatgcct gctgaatctc ttcatagtag acatgcgccg tattacaagg cagcgcaatg 3215701 aaatccacgc ctgttttctc gagctttacc gctccgtcga taatcgcttt tttcatctcg 3215761 tcatggtcaa ttggacgatc tgcatagaag ggcgtcgggc atgaatagat catcatgtgc 3215821 ggatagtcaa tatcgtttga agccccatac agcttctgac agtaatcaat caccttatca 3215881 ataaacggcg aggtcgattt cggccccatt ccggctaata ttccgatcat caaattcatt 3215941 cctttctact tcgtacggac cgcttcttcc tctgagccat cctcatagag gataaagctt 3216001 ttcgcagcat cctcacctaa tgtaaactcg acttcaacag acaatgctcg cagaaagaaa 3216061 cgggtttccg aggaaggaaa taactccagt ctcagctgtc cggcgatctc caaataaagc 3216121 cgttcattct cggttgtcac ctgtgcagcc gtcccatcct gcaacaggta gctgccaaca 3216181 tagcggctgt atatcgccgt atcaattgct tttttctttt tatcagcagg acgttccggg 3216241 acatcatatg gctggccaaa tagaatatgt tccgccgcct tcagaatcgc ttgttcatat 3216301 tcagtatcct cttccttatt actcaaatag atcagcgttt tacgatgatc gatatatcgg 3216361 atcatcatcg tcgaatagcc gggccatcct ccgctgtggc tgacaatccg ccctttttca 3216421 ggactgtttt gcagcaccca gccaaagcca taatcaattg tttctccatt gttgaggcgc 3216481 actggagaaa acgcagattc cttagaagcc ttgctgatga aatcgtcctg atataaagcc 3216541 tgatcaaatc gaaacaaatc gcttgtgaca gagttaaccg tcccatctcc ctgtatgcca 3216601 tcgagataca caacatagtt cgtttcctcc agctcatcag ggaggacgta tgtttcggaa 3216661 tgtacatcat acacatatcc atatgcataa tgatcaattc gctcaggcga aagcctcctg 3216721 ttatacactc ttgtttcatt catgcctgcc ggtaaaaaaa tacttgtttt tataaaatcc 3216781 gcatagctca tgccagatgc tttttcaatg ataaccgcca gcagcacata ccccgtattg 3216841 ctgtacatcc agccttcatt cggttcaaaa taaccagata gcccctcatt catcagcata 3216901 tcgacaatat cctgattcac cgcaatcttg tgtgaatccc aattggcaaa aaaccatccc 3216961 atataatcag gaagccctga cgtatggttc aataaatgcc gaatcgttac gccctgatac 3217021 ggaaaaccgg gcagccagcg atccacttta tcctcatagc caagaatccc cttctcctcc 3217081 agcaagatga ttcccaatgc tgtaaaaggc tttgacaaag acgctaactc aaacaaagag 3217141 ttggttttca acgggcgttt ttccgtcatt tccgcatagc caaaagagtg gtgatataaa 3217201 atatcgccac cctccgcagc cagaaccgtc ccgttaaact gatgtttttc gcctaatgtc 3217261 tcaaataacg tctgaagatg ctttctttta ttctgcttca ttcctccacc tcccatatct 3217321 ctgtacgtta ctaacctact aacgtttcaa atattttgaa aaatccttca gttagagatc 3217381 ctttttaacc catcacatat acctgccgtt cactattatt tagtgaaatg agatattatg 3217441 atattttctg aattgtgatt aaaaaggcaa ctttatgccc atgcaacaga aactataaaa 3217501 aatacagaga atgaaaagaa acagatagat tttttagttc tttaggcccg tagtctgcaa 3217561 atccttttat gattttctat caaacaaaag aggaaaatag accagttgca atccaaacga 3217621 gagtctaata gaatgaggtc gaaaagtaaa tcgcgcgggt ttgttactga taaagcaggc 3217681 aagacctaaa atgtgtaaag ggcaaagtgt atactttggc gtcacccctt acatatttta 3217741 ggtctttttt tattgtgcgt aactaacttg ccatcttcaa acaggagggc tggaagaagc 3217801 agaccgctaa cacagtacat aaaaaaggag acatgaacga tgaacatcaa aaagtttgca 3217861 aaacaagcaa cagtattaac ctttactacc gcactgctgg caggaggcgc aactcaagcg 3217921 tttgcgaaag aaacgaacca aaagccatat aaggaaacat acggcatttc ccatattaca 3217981 cgccatgata tgctgcaaat ccctgaacag caaaaaaatg aaaaatatca agttcctgaa 3218041 ttcgattcgt ccacaattaa aaatatctct tctgcaaaag gcctggacgt ttgggacagc 3218101 tggccattac aaaacgctga cggcactgtc gcaaactatc acggctacca catcgtcttt 3218161 gcattagccg gagatcctaa aaatgcggat gacacatcga tttacatgtt ctatcaaaaa 3218221 gtcggcgaaa cttctattga cagctggaaa aacgctggcc gcgtctttaa agacagcgac 3218281 aaattcgatg caaatgattc tatcctaaaa gaccaaacac aagaatggtc aggttcagcc 3218341 acatttacat ctgacggaaa aatccgttta ttctacactg atttctccgg taaacattac 3218401 ggcaaacaaa cactgacaac tgcacaagtt aacgtatcag catcagacag ctctttgaac 3218461 atcaacggtg tagaggatta taaatcaatc tttgacggtg acggaaaaac gtatcaaaat 3218521 gtacagcagt tcatcgatga aggcaactac agctcaggcg acaaccatac gctgagagat 3218581 cctcactacg tagaagataa aggccacaaa tacttagtat ttgaagcaaa cactggaact 3218641 gaagatggct accaaggcga agaatcttta tttaacaaag catactatgg caaaagcaca 3218701 tcattcttcc gtcaagaaag tcaaaaactt ctgcaaagcg ataaaaaacg cacggctgag 3218761 ttagcaaacg gcgctctcgg tatgattgag ctaaacgatg attacacact gaaaaaagtg 3218821 atgaaaccgc tgattgcatc taacacagta acagatgaaa ttgaacgcgc gaacgtcttt 3218881 aaaatgaacg gcaaatggta cctgttcact gactcccgcg gatcaaaaat gacgattgac 3218941 ggcattacgt ctaacgatat ttacatgctt ggttatgttt ctaattcttt aactggccca 3219001 tacaagccgc tgaacaaaac tggccttgtg ttaaaaatgg atcttgatcc taacgatgta 3219061 acctttactt actcacactt cgctgtacct caagcgaaag gaaacaatgt cgtgattaca 3219121 agctatatga caaacagagg attctacgca gacaaacaat caacgtttgc gccaagcttc 3219181 ctgctgaaca tcaaaggcaa gaaaacatct gttgtcaaag acagcatcct tgaacaagga 3219241 caattaacag ttaacaaata aaaacgcaaa agaaaatgcc gatatcctat tggcattttc 3219301 ttttatttct tatcaacata aaggtgaatc ccatatgaac tatataaaag caggcaaatg 3219361 gctaaccgta ttcctaacct ttttaggaat attgctgttt atcgacttat ttccaaaaga 3219421 agaacatgac caaaaaacaa aatcaaaaca gaagccggac taccgggcgg catatcattt 3219481 tacgacgccg gataaatgga aaaatgaccc tcaaaaaccg atctattttg atggcaagta 3219541 tcattatttc tatctatata accgggatta cccaaaaggc aacggcacag aatggcgcca 3219601 tgccgtctca gaggatttgg tgcactggac cgatgaaggc gtggcgattc cgaaatatac 3219661 aaacccggac ggtgatattt ggaccggttc cgtcgtggtg gataaagaga acacagccgg 3219721 cttcgggaaa aatgcgcttg tcgcgattgt gacacagccc tcagccaaag acaaaaaaca 3219781 ggaacaatat ttgtggtaca gcacagataa gggaaaatca ttcaaattct acagtggcaa 3219841 ccccgttatg cctaatccgg gcacagacga tttcagagat ccgaaagtca tatgggatga 3219901 ccaagataac aaatgggtca tggtcatggc tgaaggatca aaaatcggct tttatgaatc 3219961 cgataatctt aaggactggc attacacaag cggattcttc ccagaacagg cgggaatggt 3220021 ggaatgtccc gacctctaca tgatgcgggc aagcgacgga acgaataagt gggttctcgg 3220081 tgccagcgcg aatggcaaac cgtggggcaa accaaatacg tacgcctact ggaccggaag 3220141 cttcgacgga aaagaattca aagcggatca gactgaagcc caatggcttg actatggctt 3220201 cgactggtat ggcggtgtga cgttcgaaga cagcaaaagc acagatccat tagaaaagcg 3220261 gtatgcgctt gcctggatga acaattggga ttatgccaac aacaccccga caatgaagaa 3220321 cggctttaac ggcacagatt ctgtcatacg cgaactccgg ctgaaggagc aggatggaac 3220381 atacagcctc gtctcacagc cgattgaagc tttggagcag ctgactgttt caactgacga 3220441 aatagaggat caggatgtga acggatcaaa aacattgtcg ataacaggtg atacgtacca 3220501 gcttgatacg gatctttctt ggtcagagct aaagaatgca ggcgtcaggc tcagagaatc 3220561 agaagaccaa aaacgccata ttgatgtcgg cattttcgct gaaggcggct atgcttatgt 3220621 caatagagca gccacaaatc agcctgacaa aagcaatacc tatgtcgaaa gcaaagctcc 3220681 ttatgatgta aacaaacgta aggtgcattt gaaaatactt gtcgataaaa caacgataga 3220741 agtatttgtt ggcgacggga aaaccgtttt ttcaaatgaa gtcttcccaa agcctgaaga 3220801 taaaggaatt accctttatt ctgacggcgg cacagcctcc ttcaaaaata taacagtgaa 3220861 acactttgat tcgattcatg aataaaaaca ggggcggcgc aggctgcccc tgttttttta 3220921 ttaggagcgg tattctctgt tacatattgg gcattgtaag gaatataagg ctggtttcaa 3220981 aggaggaagc gaatgtctaa acaaggaaat tttcaaaaat caatgtcgct gtttgatctg 3221041 attttgattg ggatgggagc catctttgga tcagcgtggc tgttcgctgt cagtaatgtc 3221101 gcttcaaaag cagggccctc cggcgctttt tcctggatcc tcggaggagc cattattttg 3221161 ttaatcgggc ttgtatatgc ggagctcgga gccgctctgc cccgtaccgg aggcatcatt 3221221 cgataccccg tttattcaca tggccacctt gtcggctact taatttcgtt tgtcacgatt 3221281 gtcgcttata caagcttgat ttcaattgaa gtgacagctg tgcgccagta tgtggcctat 3221341 tggtttcccg gcctgaccat taaagggtct gattcgccta ccatttccgg ctggatcttg 3221401 cagtttgccc tattatgctt gtttttcctg ctgaattatt ggagcgtcaa aaccttcgct 3221461 aaggcgaatt tcatcatatc gatttttaaa tatattgtgc cgattaccat cattattgtg 3221521 ctgatctttc attttcagcc ggagaattta tccgttcaag gatttgcacc gtttggattt 3221581 acaggtattc aggctgccat ctcgacaggc ggcgtcatgt ttgcgtatct cggcctgcat 3221641 ccgattgtat ctgtagcagg tgaagtccaa aatccaaaac gcaatatccc gatcgcttta 3221701 atcatttgca tcatcgtttc aaccatcatt tatactgttt tgcaggtcac ctttattggt 3221761 gcaatcccga cagaaacact gaaacatggc tggccggcaa ttggccggga gttctcattg 3221821 ccgtttaagg atattgcggt catgctcggg ttaggctggc ttgcaacgct tgtcatttta 3221881 gacgccattc tgtctcccgg aggaaacggg aatatcttta tgaatacgac atcccgcctt 3221941 gtttacgcct gggcgcgtaa cggcacatta tttggcatat tctcaaaggt caataaagat 3222001 acggggacac cccgcgcttc gctttggctt tcgtttgccc tgtccatttt ctggacactt 3222061 ccctttcctt cgtggaacgc gctcgtcaat gtctgttcag tcgcgctcat tctttcatat 3222121 gcgattgcac ccatttcttc agctgcgctg agggtcaacg cgaaggactt aaacaggccg 3222181 ttttatttaa agggaatgag cattatcggg ccgctttcct ttatatttac agcgtttatc 3222241 gtgtactggt caggatggaa aacagtctcc tggctgctcg gttcacaact cgtgatgttt 3222301 ttgatctatc tctgtttcag caaatatacg cctaaagaag atgtcagcct tgctcagcag 3222361 ctgaaatcag cctggtggct tatcgggttt tatattatga tgctgatctt ttcctacatc 3222421 ggttctttcg gacatggttt agggattatc agcaatcccg tcgacctcat tttagtcgcg 3222481 atcggctcac ttgcgattta ttactgggca aagtataccg ggctcccaaa agccgccatt 3222541 gattatgata aataaagaag caagaggttt tcttgcttct ttattcttta caaacaaaca 3222601 tacacgcgat aaaatgaatg agagtcagtc attactggag gtgttcctca tgccaaaaca 3222661 aacatcgggt aaatacgaaa aaatattgca ggcggccata gaagtcattt ctgaaaaagg 3222721 cctcgacaaa gcttctattt ctgatattgt caaaaaggcc ggcactgccc aaggaacatt 3222781 ctatttgtat ttttcatcta aaaatgccct cataccggcc attgcagaaa atctcctcac 3222841 ccatacactt gatcaaatca aaggtaggct ccatggggac gaggattttt ggaccgtttt 3222901 agatatatta attgatgaga catttctcat tacagaacgc cataaggata ttattgtcct 3222961 ctgttattcc gggcttgcga tcgaccactc catggaaaaa tgggagacga tctatcagcc 3223021 ttattattcc tggcttgaaa aaatcatcaa caaggccatt gcaaaccatg aggtaacgga 3223081 aggaatcaat tcaaaatgga cggccagaac gattatcaac ttggtcgaga atactgcgga 3223141 acgattctat atcggatttg aacaagatga aaatgttgaa gtgtataaaa aggaaatttt 3223201 cactttctta aaacggagct taggtactgc ttaaaaaatg actgggtaac accgctcatt 3223261 ttttaatgcc ctaaaaatga ctgacgttca ttcataaaat agagaggtgt ttcatttgaa 3223321 ttgggttctt gtttttattg cagggctttt agaggttgtt tgggcctctt ccctcaaaca 3223381 tgccgattcg cttttggatt ggatcatcat ttttatctta atcgcggtca gctttatcct 3223441 gttgatccgc tcttatcaaa aaatcccgat ggccgcggcg tacactgtgt ttgtgggaat 3223501 cggaaccgtc ggaacatatc tgactggaat tgttctgggc gaatccttct cagcagccca 3223561 aatgttcttt ttagctttat tgctggctgg cattttagga atgaaattat ttacgaaaga 3223621 aagcaaatct cagccgggag gtgaaaaata atggcatggt ttttattagt gattgccggc 3223681 atagaagaaa ttatagctgc cattgccatg aaatatatag acggaacaag aaaaaaatgg 3223741 ccgatcattg tgatgactgt tggattcggc ttatcctttt actgcctgtc ccaagcgatg 3223801 atcgtcctgc ctgccggagt cgcatatgcc gtctggactg gcattggaag cattggtgtt 3223861 tcggcggtcg ggctcatctg gtttaaggag cggtttcagc tttcacaggt gatttcactt 3223921 tgccttatcc tagccggcgt catcggcctg cgtcttacgt catcttcata aaatcaaggc 3223981 atatacagct gtatatgcct ttgccattaa gcttcgtgat gtttttgaag atgaagcggc 3224041 ggcgggatga gccagccttt gttttttagc agccttaagt attttgcgcc ggttgccgct 3224101 ttcgacatat gaaattgccc aaacatcatg gcaatatcct cacgaatcga ttgccccatc 3224161 attttgctgc atgtcacaag acctgcagca ttttctgctg ccgcggaagc cgccacatcc 3224221 ggatcgagaa accgtgcacc aggcggaata tcgttaagat ctgctgtcgg cggttcagga 3224281 gaagccggcg gcagcgccac cccgttttct ttcaggatcg tgctgacctg tttgatttca 3224341 tcttggcatt tctcaataga ctcacgaagc agcttcttca ggtcgtcatc accgacatga 3224401 ttcaatagca tttggtaatt gccgaccatt ttattgcccg ccatcacata actccacaag 3224461 ccgaatacct caccgtaatg catcggttca tcctgcggat ttccgcttaa aatacccatg 3224521 ctcattctcc tcccatattc aatattgcac atttcataac gtgcccaagc ggaggaacat 3224581 ttatgtttca gcggaaaaga tttatgaaat gaaacaaaac aaaaaagaca agagtggcaa 3224641 gttgccaaac cattgtcttt cctgttgttt gattggacgc actgaaggga ttcgcacccc 3224701 gacagacaag ataccggaaa ccattcaagt gctttttagt atgagtcatt gattctgtct 3224761 ttaataaact ttaacgagat ggcgggatgc tttgcggaaa acgaaataca ttttcggggt 3224821 catatttcgc ctttatttct cgaagccgcg caaagtttgc gccataatat tcttttccga 3224881 agttttcaat gttttgatct ggaacattaa catatgaacc tgctacatat ggttgcatca 3224941 gctgacgcac tctttcaact gatgcaagat ttgaatcttc ttgtgattta tttttccaac 3225001 tagccgtcca ttccgtataa aataatggat ggcgccaaaa aaaggcagtt tcgtctttag 3225061 ggactctgct tatagcacca ccccaattga taaaaaagaa attggcttct gttccagtag 3225121 catcttccaa aaattttctc atgattgaaa tgggttcgtc agaccaaaaa tcatgacccc 3225181 atgccgagga gaatttaaca ctctgatcat ttctgccagg gatgggttcg tcagggtcta 3225241 agaaatctat agcatctgga tagtataatg ttttgatatc tgcttctgtt ggagttcccg 3225301 catgtaataa aggttttaat aatcgaatca attcagtttt cgaaccgagg aaaattcctt 3225361 ctgcatgaca caaaccattt attttgctgt aaatttcaag gtagcatcct aatcgttcat 3225421 ctacaaacgg agcccatttc tgccaagctt taaataccgt ttctaattgt tcccacggcc 3225481 agataatatt gaagacggtt gcagttttag gggcacgatg aactttgaat gtatattggg 3225541 tattatatcc aaagttacct cctcctccgc ctctagaagc ccatagcaaa tcctcattgt 3225601 gagattgatc tgcgtgaata atccttcctt ttgcatctac cgttttcagc gcgagaaggt 3225661 tatcacttat aaggccaatc gatcgtgaga gtacaccaaa tccgccgccc atcgtaattc 3225721 ccccgattcc aactgttggg ctatctccaa acggagccat aaaaccgtct cgagctaatc 3225781 cctttacaag cgggccaacg ggaataccag tttgaacggt tgcaatagcg ttttcttcat 3225841 ctaagaaaac tttattcatg tcactcacat caataacaat tcctccactt actactgaaa 3225901 ggttcttatc taaagcatgg cgaccgcttc tgacacgtaa gggcacttta ttctcacgag 3225961 cccatttaat ggcattactt acatcgtatg aattttgcgc aaaaacaaag acaagaggat 3226021 agacatccac ataagggttc caattcttaa tagcctctgt atagccgggg tctcctttga 3226081 agattacacg ccctgtcaac tgtgttgatc ccatatatta tttcactccc aaagaaattc 3226141 gattcagata ctaaaatatg caggagctgg ataatcgcat agacaaatga tctacgaact 3226201 ataaatataa tacgctaagg cctttttcgt cggtgaggtc tgctgagaaa catttttcaa 3226261 acaattttga gcaaacttcc tgtccaatcc tccaacaagc gttttttctt atcgttttta 3226321 ggagcagtgt ccagtttttt tcggagtgaa tattcgttta ggccaaaaga aaagagagat 3226381 gaagaagtgt ttagtaccag aggtatacat ccatacaaca gactctagat catcatatac 3226441 tgaatgtatg tagaaaggag acatcagctt tggcaaaata tcggattatg acctttgacg 3226501 gcggcggtac cttaggtgct ttaagtttac aactattaaa cagattggct aggcaaaacc 3226561 cgaagttaat tagtcgaacc catgtatttt cgggaaattc aatcggttca tttactgccc 3226621 ttgcattagc aagcggaaga tctccgaggg aaacacttca gtattttgag gatgaaatcc 3226681 tacccgcatt cagcatttcc cggccaggcg gacctgtttt caaccaacaa ttaccctatt 3226741 ccggttttat taaagcggta agaaattttt tcccagcaga tcttcaactt atagatttaa 3226801 gaaaacgaat tgttgtccca tcattcaaat tatactctca aaaactggac cgttggactc 3226861 ctgtcttatt tcacaatttt cccggctctc cctatttaaa tgaaaaagtg agtgatgtca 3226921 tactgcggag cagcggtgct cccgcgacgc aacgcgccta tcaaaactat gtggacggat 3226981 atgtagtagc aacgaatccc agtacagcca gtatcgcgtt tgcagttggt aaagccaacg 3227041 tgccattgga tcaaattgcg gtattgtcca tcggaacagg tgaagccccg actcggttaa 3227101 gaagagatac gaggggatgg ggaatggtaa gtgcagataa catacgtccc gaaaatctga 3227161 agaaccttcc tccaaattgg ggagtccttt tggacaggtc gcctaatgaa cctttactgc 3227221 catttcttca gatgattgct ggcggtaatg ggtactatga atccatggtc agtgcgaatc 3227281 ttctgggaga tcgttttttc cggttagatc cgcggattcc gaacttctcc aaaacggacc 3227341 ctgccgtcgt tcccgctgtc attgaaattg cgaacaaaac aaacttacag cctgcgaatc 3227401 aatttataga gaagaactgg gggagcaaat aattatttat tttaaatcaa ttctcgctta 3227461 tacaattttg tccgagagaa gattctcaaa ataaatacag gcaatgggta gaaccggatt 3227521 tttttaaagg tttgttaatc acaagctaat aagatgaatg aaaaaatcaa ttcatacttc 3227581 ttcttttgaa agtgagggtt caaactaaag aatgtaattg aaatgttact ctaaggtatg 3227641 caattccctt tttcacacaa aaaaagacaa gagcggcaaa tcgccaaacc cttgtctttc 3227701 ctgttgttct attggacgcg ctcggaggga ttcgaacccc cgacagacgt ggtaccggaa 3227761 accaccgctc tatccaactg agctacgagc gcatatagac tgcgttatga gaacgtcagc 3227821 acaactaatt atacgataat tcctttcaaa taacaaccct ctatttcgag aggccgtttt 3227881 ttaaatagac aaagcatctt aattggcaat ctgacatacg atggtttgaa cccctgtatt 3227941 tttggggaaa atgggaaaaa gagacgactt tgcatatcag gccagctttt tgtttgacct 3228001 ttattgacca aaaatgtatc atgtaactac atacttacct aaaaggtgaa ggaggagcat 3228061 tatgaattta atacctacag tcattgaaca aacgaaccgc ggggaaagag cgtatgacat 3228121 ttattctcgt ctattaaagg atcgtatcat catgcttgga tctgcgattg atgacaacgt 3228181 tgcgaactcc atcgtgtcac agcttttatt cttagcagca gaagaccctg aaaaagaaat 3228241 ttctctttac atcaacagcc cgggcggctc tattacagcc ggtatggcga tctatgatac 3228301 catgcagttt attaagccga aggtatctac aatttgtatc ggtatggctg cgtcaatggg 3228361 cgcgttcctg cttgcagccg gcgaaaaagg caaacgctat gcgcttccaa acagtgaagt 3228421 catgattcac cagcctcttg gcggtgcgca aggtcaagcg acagaaattg aaattgctgc 3228481 gaaacgcatt ctcttgcttc gcgacaaatt aaacaaagtc ctagctgaac gtactggcca 3228541 gccgcttgaa gtgatcgaac gcgacacaga ccgtgataac ttcaagtctg ctgaagaagc 3228601 gcttgaatac ggcctgattg acaaaatttt gactcacaca gaagacaaaa agtaataaca 3228661 caacctgcaa gagctgcgtc tcttgcaggt ttttttcatt tcaaggaatt gactccctta 3228721 ttctatactg ctcccattcc tcatgtaaca gctcaagcgt caaatcactc gtctgcctca 3228781 caaccagatc agcaccaagc atcggctgtc cttgaccgac accaaccgca aacatccccg 3228841 cagatttgat tgcagaaatg cctgcttctg cgtcttctat tgccgcgcaa tcagcagggg 3228901 aaacatcgag catcgctgca gctgttaaaa agatgtcagg atcaggcttc cccttcgcaa 3228961 gagtcgtcgg atcaacaatg gcatgaaaat catcgataat tgccaagcgt cttaaaatct 3229021 taggagcatt gcgacttgaa gatgctaacc cgatttttat attttcgttt ttcaattgac 3229081 atagaagcct gccaatcccc ggtaaaagat cttccggcgt caatttgctg atcagcattt 3229141 gataatcgcg atttttccga tgcataagct cttgtttctc cgcatttgta tactttgttt 3229201 ccgccccgcc aaagatcaat atgctttcaa gtgactcttc tctgctgatt ccttttagcc 3229261 tttcattcat gtctctgtca aaagggatat cgatttgttc tgcgatgtgc ttccaagcga 3229321 gaaaatgata ttcagcagta tctgttatca ctccgtctaa atcaaaaatg accgctttca 3229381 tatactaatg cccatcacag cttcataagg tttgaggcta atactcttta agtcagcccg 3229441 ctcctgcgga tagtttgaaa ttagcacttt ccaacgctca tgaatcagtt ctggaggcgc 3229501 ttcgaacaga gccttttctt ccgataaatt cacaacgaca agaagctttt cccctcgata 3229561 ttctcgaagg taagaaaaga cctgcggatc attctcctgc aacagctgat aatcgccata 3229621 tatcataatc ttatattgct ttcgtaattg aatgagcttc tgatagtaaa agaaaatcga 3229681 atcttgatct tccaaagact ctttcacatt gatatcttga tagcgggaat ttaccggtat 3229741 ccacgggtct ccggctgtga atcccgcatg ttttccggca tcccactgca tcggtgttct 3229801 cgcatgatcc cttcctttta tcatcacggc tttgacaaac tctttttctg acatcgtttt 3229861 gttttcgacg actagttcac gatatgcatt ctttatttca agatcatcat acatctccag 3229921 cggcatatcg ctgttgacca tgccgatttc ttctccctgg taaataaacg gcgttccttt 3229981 catgccgtgc agaaccgttg caaatgcctt cgcacattcc ttacgcagtt tcctgtcatt 3230041 gccccagcgg gaaataaccc tcggctggtc atggttctca aaataaaggg tattccagcc 3230101 gacattcatt aacccggtct gccaccttgt catcgtcttt tttaaagcaa tcaaatcaaa 3230161 cggcttgatc tgccatttcc catttggcga gttttgttct ttatcaatat ccatatgttc 3230221 aaatgtaaag atcatattca gctcttgcct gcttgcatct gtgtactttt tcgcctcttc 3230281 aatatcagag ccgtttgcct ctccgactgt catgcagtcg taatgagaaa gcacttccct 3230341 gttcatctct tgaataaact catgaagacg tgggccgtta gagtgataac ggccgacaat 3230401 atagctgcgg ctgtgatccg tttcgtagtc cggaaaatcg gtgtatttag aaatagagcc 3230461 aatcacatcc atccgccagc cgtcaacgcc tctatccatc cagaatctca ttacatcata 3230521 aacttcccgg cgaacggctt cgttttccca atttaaatca ggctgttttt tcgaaaagta 3230581 gtgcaaataa tactgccctg ttccttcatc gtatgtccac gctgagcctg aaaagatcga 3230641 tccccaatta ttcggctctg agccgtccgg tttaggatct ttccaaagat aataatcccg 3230701 gtaaggattg tccttcgact tgcggctttc agcaaaccaa gcatgctcat ctgatgtgtg 3230761 gttcacgacc aaatccatga cgattttcat tccgcgttta tggacttcat caatcagctg 3230821 aaacatatct tcatttgtcc caaacttttc gtacatgttt ttgtaatcgc tgatatcata 3230881 tccgttgtca tcctgcgggg aatcaaatac cggggagagc cagatgacat ccgccccgag 3230941 gtttttgatg taatccagct tttgaatcac accttgcaaa tctccgaatc catctccatt 3231001 ggcatcataa aaactgcgcg ggtaaatttg ataaacgaca gcttctttcc accattcact 3231061 cattaggcgt tctcctttca catcgtccct gtaggacaac cggttcctca taaacgttca 3231121 tgtgcagcgg ctcgcctttt acaagctcaa aaataacgcg cttttcgtca accgtcacat 3231181 tgattaatcg atttcgataa ttgatgttga atgaatattc gtcccattct ttcggcaaaa 3231241 acggagcaaa tgacagcgtc tcattcgcgg tgcgcatgcc tgcaaagcca tgaacgattg 3231301 ccagccagct acccgtcatt gaagtaatat gcaagccttc ttccgtatca tgattgtaat 3231361 tatcaagatc aagccttgct gtgcgcttat ataattcgag cgctttcttt tccagcttga 3231421 gttcggctgc gagaatcgca tggacagagg gcgataggct tgattcatga acagtcatcg 3231481 gctcataaaa ttcaaaattt cgccgttttt cttccattgt aaaacggtca ttaaaaagat 3231541 aaatgccttg gagaacatct gcctgcttaa taaaattgga gcggagaatc ttgtcccatg 3231601 accaattctg gtaaagaggc cgttccgctg gatctaattc gtcaactgtt tgcaggtctt 3231661 tgtccaagaa cgtgtcatgc tgaacgaaaa tttgcagttc ttcactaaat ggatagtaca 3231721 tgtgctggat gatttctctc cagacttcca attctacttc ctgcacatcc agatggcggc 3231781 gtttctccgc tgagatactt tcgagacttt gtagagtata ctccaacgtc caagccgcaa 3231841 tgacattcgt ataccaattg ttgttaacgt tgttttcgta ttcattcggc cctgtgacgc 3231901 catggatcat atacttattt tttcgtttcg agaagtgaac acggtcggcc caaaatctgc 3231961 tgactgccac aagtacgtct atcccgtatt cttccatata gttacggtcg cctgtataat 3232021 tgatataatt gtagatcgca taacagatcg cgccattgcg gtgaatttct tcaaaggtga 3232081 tttcccattc gttgtggcat tcatcacctg tgaacgtcac catcggataa agtgccccct 3232141 tcatccccaa ttttgcagcg tttcgtttgg cagcctccaa ctgatgatag cgatacaaaa 3232201 gcaggttttt cgtcacctcc ggctcggctg tcgccaaata catcggaacg gcgtacgcct 3232261 cagtatccca atatgcggca cctccatatt tctcgccagt aaatcctttc ggcccgatat 3232321 tcaaacgggc atcgcccccg taatatgtcg agaataactg aaagatattg tagcggattc 3232381 cttgttgaag ctcctcatct cctttaatct caatgtccgc ttttgcccat ctttccttcc 3232441 atcgatcagt gtgcctccgt tttgcatctt catagccgtt ctctaccaca tccgccaaaa 3232501 gctccttggc tttcgataaa agctcttcct cccgaaaatc acgggaagtc gtgacaatca 3232561 caaacttttt caatgatgcc ttcgtttgat aactgtagcg attctcgaca tacatttcag 3232621 tcgttttaaa gctttcatgg acaaaaccct ccgtctcgtt tgccattgcg gctaataccg 3232681 tgaagcgcgg tgttccaaat ggattttcga tcgtttttgc cgctaaatgg ccgctgtgag 3232741 aatcagcacc tttcgcttcc tcctgccaaa actgttcttg gtagttagaa tcttcatttg 3232801 ccacatttcc atccaggtaa ggaacaagcg taatgacagc atctcccgtc aagcactccg 3232861 cttcataatg aatcgcacag agttctttta cagcaaggct aagaaaccgc tctgacctga 3232921 ttctgacggt tttatcttga atgcggacaa cagcgcttcg ccgcagaatc ccctctttca 3232981 tattgagttc tacctcaaat aattcgattg ggttttgatg gagatcgatt ttttcaccgt 3233041 caacatatag gcctatgccc ataaagttca tcgcattgat cacttttccg aaatattctg 3233101 gatacccgtt tttccaccag cctactcgcg ttttgtcggg gaaccacacg cctgcaatat 3233161 atgtgccttg gtgactgtcg cctgaatagc cttcttcaaa attccctctg acccccatat 3233221 agccattggc aagagacgtc aggctttcca gcagccgtgt atgctcctta ttaaatgtat 3233281 ttgttttgat tttccattca tcaatctcaa ataaccgctg atttatcatc atttcctccc 3233341 gaatgtaagt ttccattatc acggcgggtt ttggtcaaat atctaaatgc aaaagagatc 3233401 atcaaagtaa cgccacacga atggatcatc aatacagtaa tcaaatcaaa atgaaccatg 3233461 ccgatagcag ctgccgcaaa tgccggcagt gctgatgcgc aaatcgctat agaggccgct 3233521 tccttgaatg atgcaataga gaccatgttt gatatttttg tgatccagag gccacctgca 3233581 agaacaaacg ttaacaaaag ctggatcata gaaaccaccg tatatgccag catcatgatc 3233641 atcggcttat actgtgccaa ccacaatgta tcgatcaaga cctctacatc atggacgttt 3233701 ggtttctcga gcttaacgtc cattttcgca tagccaacag aaaaccccgt ttcgttttga 3233761 tcggtgatca ccagttgatc aggttgaaat atgatggcgt tttcaaatcc agttactttc 3233821 aatcgcccat tttcaccgct tgtctcatat tcatgcttca tatcgactgc catcacattc 3233881 tgcccatctt caatcctctc agagctcttc ccgcctgtta gttttccgtt cctgatttga 3233941 aaaccctgca attgatcagc aaattgatca ttaactcctt gaatcgctga cggcatgaaa 3234001 gatgaaacgc tgaagcgatc cattttcaca aacgaaaccg ctaacggcgc cattaagcag 3234061 gccgttaaaa acagaaagag aaaagagagc tgcagccagc tgaaggtatt cccatagcgg 3234121 caaacacctg atggggatgc agccgccttc aggcagcgga tgataaagct tttattctcc 3234181 agattcttca ttggcattac ccctttgttc cgccggctgt caaaccggac acaaagttct 3234241 tttggagaaa aaagaataga acgcatatcg gcagtgcggc tagtatggca ccggctgcaa 3234301 atagagctac tttttgctgc tgcggattag aaataaagga ttgtaatcct acagcgatgg 3234361 tcagcctttc cggtgagcga agcagaaatt tcgtcagcaa atagtcgcca aacggtgcca 3234421 taaacgccca aagcgcttgt accgcgagca ttggcttaac aagcggtaga acaattgaag 3234481 cgaaaatcct cagatgtccc gctccgtcaa ttcgcgcggc ttcatcaatt tctctcggca 3234541 cagtatcaaa ataacctttc atcagccacg tgttcatcgg aattccgccg ccgatataga 3234601 tcgctgttaa aaaccagtat tgatcgagtg cgcctattag catcgccaag acataaaaag 3234661 cagtcagcgc cgccattgtc ggcaccattt gaatgattaa aaagaatatc aggctctttt 3234721 ttctgcctgc aaaccgatag cggctgtacg agtacccggc aagtgtcaca atcgtaacct 3234781 gcaaaaccat gaccgatagc gcgatgacaa gtgtattgct gtaccaattg agataaagcg 3234841 tttcgtcaaa tagccgctta aaatgatcca atgtccaaga acccgaaaaa tcgagctgaa 3234901 aagccgccga attccccaca cggaaggctg atgatgccgt aatcagcaac ggatatataa 3234961 tgacaatact taaaagcgtc aaaaataaat acgtacagat tttattaagc attctggcag 3235021 tgctcgcgtt cacctacata acctcctcat tgccaaaagc attcgatttt ttgaaagcaa 3235081 tcagtgaaat tccaatgaca atgaaagaaa ttaacagtgt cacagccgcc gcaacggaat 3235141 attggggtga tgtgcctgtt gtcagtttat aaatccacga aattaagata tcggtcgatc 3235201 cggccccggc tcccgcactg cctggccctc cctcattaaa taaatagatg atcgagaaat 3235261 tattgaaatt aaacgtatac tgagtaatca tcacgggtgc tgtggcaaat aaaatcatcg 3235321 ggaatgtaat atgccgaaaa cgctgaataa aagtggcccc gtcaatcttt gccgcttcat 3235381 acaattcacc tggaatcgcc tgaagcactc ccgttaccat gacatatata tatggaaagc 3235441 cgagccacgt ttgaatcata atgagggctg tctttgtcca gaaaggatcg gtcttccacg 3235501 cgatcgcagg cagctcgaca aacggcaggt gattgaataa tggtatcacc tgtgcattca 3235561 ccgctcctat gctgtcgtta aacatgttgg aaaaactcat gattgtaata aacgccggaa 3235621 cagcccatgg aaataagaaa atcattcgaa atatccgctt gccttttata aaatcctgat 3235681 tgacgaaaag tgccgtcaca atacctaaaa tgatttgcag cgttgttgca cagattgtcc 3235741 agataaccgt ccagcccagt acattcacaa atgtttcacg ataggagcca aggaaaaaaa 3235801 tatttaagaa atttttaaac ccgacccagt caatcagacg attaggcgga atatgataaa 3235861 aatcatagtt tgttaatgca acaaacagag tcaccaaaac cggaaaaata atcacaaaca 3235921 ccatcatgat atatgccggc agtgtaaata gatacggaaa acctttatcg cccgcatgac 3235981 agatcatatc cttggctgtt gtattgactt ccaaacccgc cgctttcata gcggcggtct 3236041 tacgtgaatc atgaatatta aagatataga acatgaggaa aatcattgtc acgatcaatt 3236101 gcagcgtgcc ttcaatcagc ataaacagcg agtgatcttc accgggaaca cttcccaatg 3236161 tcatcaatcc ggttagcgcc tgtataccga aaacgcataa ttcaaaagca aacaagcctg 3236221 tgatggcaag aaataagagc ccctttgaca actgctgatt cgcaatctgc ccaagtcctg 3236281 gaatgatcga taaaagccct gcctttcgtt tttgctttgt aagtgtgtga tgtttattca 3236341 tttttccgcc ctctattctt ccggacgcta tcccgccgtt ttatttcaca tacttttctt 3236401 taatattttc ctttatgacg tttacagcat cattcgctga tgtttgtgtc gatttttttc 3236461 ctgaagctgc atcaaaaatt aaactttccg ctcctgtcca tacttcagcc atttccggaa 3236521 tatttggagt cggcgttgct gtttcatatt gtttaatcac agctgacgtc agttcattct 3236581 tttgctcatc ggctttcttc cttgcagccg tgttggccgg aacttcgttt gtatcctcat 3236641 aaaaagcgta agcattggca tcatttgcag catactcaag ccatttttca gccagctcgg 3236701 gctcttttgt atatttcgag gcaacccagc ccttcccgcc agcaaaaggg gcgtattctt 3236761 ctccatttgg caatgtcgga atgggagccg ctccgtagtt caatttagcc tctttatagt 3236821 tggcagctga ccaaggaccg ccaatgatcg cagccgcttt gccttctaaa aacatctgct 3236881 gaataaagtc gtctgcgctt gaattgtctt gcattccttt cggccaatat gtctcaaacc 3236941 atttctccgc atatttcacc gcttctacag cccctttatt gttcaggccg atgtccccgg 3237001 aatctgtgcc gttttttcca aacacatatc cgccgtatcc agccaataag ccgtacgaca 3237061 tataaaagtc agtccatttt gctaaaaatc cggttgattt tcctttttcc gaagcaaacg 3237121 cgaatcgagg atcttccgtt aacttttcaa ggtctttaaa tgtttttggc gctgttttta 3237181 aaagatcttt gttgtaatac aaaataagtg tctcaatgac tagcggcatt ccgtacactt 3237241 tgccgtcaac tgtcacctgc tgcatttctt tatcaccaaa gctttttgtg ttagatggct 3237301 taatatcaag taaatgtcct tgttgtccca aaccgccgat ccggtcatat gcagcaagca 3237361 taacatcagg cgcattaccc gccgggccat caagaggaag cgcttctaac tgttcgaaca 3237421 tttgcttttc aacaattttt actgtgacat cattttcttt ttcgaacttt gtttttatgc 3237481 tttcaatgta ttctttatac gtttcttcga cagacacagt cagcaccttt ttgccatcag 3237541 agcttgctgg attttttgaa cttgagcagg cggcaaggcc gattgccagg aatgatgccg 3237601 ccaatatggc gaaccccttt tttaaaagaa ccatctcttt tcctccttct atttacgaaa 3237661 ctataacaat tgtattgtcc tatagaaagc ggttacaaca actttcgatt tgttaccgat 3237721 aacagaatgt tatacagggg cggcagcact caaaatcaaa aattctcccg gctgaacggc 3237781 aatgacatcg tgatgctgta gcggctgctc tgtccatgca tcacagattt tcttattcct 3237841 atcaatattc aactctcgta aactgacgtg ttgaaccaca ttcccttgat taaagaaata 3237901 aatcagtatt ttttcatcaa gagtccgcga aaagctaatg aaatcatttt tgtcgtccag 3237961 cagattccac tcaagatgtc cttcagtcaa taaagtgttt tcctgcttgc gtaaagcaat 3238021 taaccgtttc ataaattgca gcatgtcttg gttttgcttc tctttttccc aaaccataca 3238081 tttccggcat aatggatcat tttcgccgtt cagcccgatt tccgttccgt aataaatgca 3238141 tggtgagcct gtctgggcaa acataaaggc cagcaacgcg cgtgctttct tctcatcatt 3238201 gcggcatctg gtcaaaaggc gctttgtatc atggctatcc agtaaattaa acatcacctc 3238261 attggcctgc ttcattccat tcatcaaatg tgcattgaca cggtgagcca tacgtgaagc 3238321 tgagatcgtc tggtcagcaa agtattcaat cataggctct gtaaaagggt aattcatcgc 3238381 cgcatgaaat tcatcccctc taagccaggg ttcggcagaa tgccagatct cacctaaaat 3238441 ataaacatca ggcttttcag tagatacagc ctgcctaaat gtcttccaaa aaacgtgatc 3238501 cacttcattt gcgacatcca aacgccagcc gtcaatgtca aattcgcgaa tccagtacaa 3238561 agcaatatca agcaaatatt tctgcacctc gggattagcc gtgtttagct tcggcatatc 3238621 agctgtaaaa gcaaatctgt cataattgtc gtctgtgacg ggaaaagagt gaatatggaa 3238681 ccagtcctta tagcgggatt gatctccgtt tttgacgaca tcctgccatt gcggagacgc 3238741 gcttcctata tggttaaaaa ccgcatcaag cataattctc atcccccgct gatgcagctg 3238801 gctgaccaat gtacgaaaaa gctcaggatc cccgaaatgc ggatcaatag aaaagtaatc 3238861 cagcgtgtcg tatttatgat tagaaggcgc ggaaaagatc ggtgtcagat aaatgccgtt 3238921 cacccctaaa tcctctaaat aatcaagctt gtcaacaatt ccttgtaaat cccctccaaa 3238981 aaaatcattg acgtccgggt ccttgctccc ccacggcaat gcattcttcg gtgacaagtc 3239041 ttctcttcca tttgcaaaac gctccggaaa aatttgatac caaaccgttg acttgaccca 3239101 ttcaggcgct tgaaatgtat cagcctcgtg aacaaacgga aatttaaagt aataatgaat 3239161 cgtttccagt gttttttcgt tataagggca tacacccgaa cttccgaaaa agatgtcttc 3239221 atgatcgtct gttacaacaa acgcatattg taaacgccta aatggcggca ccacttcagc 3239281 aaaccaatag tcatgcattt ctgtagcagc aattttcctc atcggctgct cgtttgccga 3239341 ccatttgccg tcgttgtact catagggatc accccaaatg aatcgaatgt gatctgcatc 3239401 accttttttc gtccgaatct tgatatgcac agtccgccca tcataagaat aagcatctgt 3239461 gctgaatggc tggtgatgaa tcgctgcata ttccatcatg tttccccctt tgatttccgt 3239521 tttattgaag ccggctcata gtttgaaagt atcatgatga aattgtggga acaatccttt 3239581 tcaccctgtt accgataaca gaataaggcg cttacagcgt tgattctcgt acaattaact 3239641 ctggttcaaa aaatagactt ccttgtgcag cgccgtcttc attcattttt ttcagcaaca 3239701 ttttcgcaca ggcttccccc atttcaacaa caggctgtct gaccgtagtc aagcgcggcg 3239761 aggagatgcg atcaagaaac acaccgtcat tcccggtaac cgcaacgtct tctggaattc 3239821 gctttccaag ggattgcgcc gcacgaatga cgccgagcgc gattcgatca gatgcgcaga 3239881 caaatgcggc ctgattgtcc atggatttca gcagttctct tgcaaggcat tcacttttct 3239941 tagaactgtt gtcgatccga aacatattcg attttttaaa gcttttattc atcgcccgta 3240001 tatacccctg ttctcttgca cgttcgaaag gctcatctaa atcaatgcca aaaaagacaa 3240061 cttcccgctc ccccagcccc ataacatggc gggttgccat aaaagtgcct ttctcgttat 3240121 tcacatcgat aaagtcatag cccatttcat tttgtccaaa tacgacgagc ggcttctcaa 3240181 aagcttttat tacaccttca aaatcgttct ttctcaagcc ggtggcaata atgccgtcac 3240241 attggccaat attaagagaa tttcttgtca caagctggag agcatagtga ttgcgatcca 3240301 gctccctgct gattcctgtc agcaggttca tgtaatatgg ttctgtcgta tccatttcct 3240361 caagtatcaa tagtttcaca acctgtgttc tgttttgcac gagcgctctc gccgcataat 3240421 tagggatgta attcagctct ttcatcgcag aatgaacaag ctttttcaat tcatccgtca 3240481 ccgtctcagg gtgattgatc actcgtgata ccgtcatttt cgaaacattt gcttttttcg 3240541 ccacatctga caatgttgcc attttcatcc cctccttatc tgtgcttatt atccaaacta 3240601 gtgataaagt cctctattac tgctaaatat acgatgcagg ccaaagagaa ataaaaaaga 3240661 gatttccctt aaggaaacct cactttgtta aaaacactcg atttttcatg gattcatacg 3240721 ctaggtggca gactcattct ctccacttcc atcagaaaat ctctttttta aatttctgtc 3240781 cacttttttt ctaaaatcgg ataagaataa ttttgcattt gctcaattaa ctcatccggc 3240841 cgtgacgagc tgtgaatcag ttttaggtgc gattcgttag aaaacccttc ttgaatgctg 3240901 tatttcacca ttttcatcat tggttcaaaa tatccgttta cattgtacag tccaattggc 3240961 ttttggtgga tgccgatctg tgcccagcac agcacttcaa ataattcttc atatgtaccg 3241021 aagccgcccg gcatcgagat aaagccgtcc gccagctcgc tcattttagc ctttcgttca 3241081 tgcatcccgt ttacttcaat cagctcagtc agattctgat ggacaacctc cccgctgaac 3241141 aaaccgctcg gcatgacccc gattgcagtt ccgccgtttt ccataatcgc gtcagcaatc 3241201 gtgcccatca agcctacgcg ggagccccca tagacaaggc cgattccctg ctcagccata 3241261 tacacgccaa gctctgccgc ttttctttta tacgcttcat ttcccccagg gtttgatccc 3241321 gcaaatacac aaatggtttt catcttgtca tctccgcatc tatatatcgt gttaaacatt 3241381 caaaaacaca ctatatattg tcccatcttc atgtgataat atcaatatga aatacataaa 3241441 gaatgcagga gtgatgaggt tgcagctggc tgatgcagaa aaatggatga aagagtttta 3241501 cgaaaaaaga ggctggacag aatacggacc ttttattcgc gtcggctttt taatggagga 3241561 agccggagaa ctggcccggg ctgtcagggc gtatgaaatc ggcagagacc ggccggatga 3241621 gaaagaatcg tcacgcgctg agcaaaaaca agaattgatt gaagaaatgg gagatgtcat 3241681 cggaaatatc gccattcttg ctgatatgta tggtgtctct ttagaagacg tcatgaaggc 3241741 ccaccaagaa aaactgacaa aacgatttga gcatgcataa aaaagcggcc gcgatggccg 3241801 ctttttttaa cctgtgattt catcatggtg atcaaagaaa tgctgctttc ctattttgtg 3241861 aaaaaggcct gttttatgca gtagctcctt cggctgcgat tgcaatccta caatcatcag 3241921 ctttccattg tggcgtttaa ttcgattcat aatgttccca agcaccgctt cagctgacgt 3241981 atccatatag tgcaccttat tcatgagcag aataagggtt ttcggttttt tctgtacatg 3242041 ctccagcaat gacgattcaa gggaatcaat tgatccgaaa aacagcggcc cttctatggc 3242101 atacatgctg acagatggat cttctctctt cgccagaaca ggatgcgttt cctgattgtg 3242161 gatgcgggtc gcttcgctca ttcttctgat aaagaacacg aatgcaagca gcaatccggt 3242221 tgccacaccg atgattaagt caaacagaac cgtaagggcg aaggtcgccg ccaaaataaa 3242281 ggaatcagca tttttcagtc tcagcatgtt tgcgacttcc ttgcgctcac tcatattcca 3242341 tgcgaccacc atgagaatcg gtgccatact ggcgagcggc acatgggacg cataaggcgc 3242401 aaatacaagc aggacaagga gaacgactac gccgtgaacg acgccggaaa ctggggaaac 3242461 cgctccgttt tttatattgg tcgccgttct cgcaatcgct cctgtagccg ggattccgcc 3242521 aaacaggggc gctgccatat tcgcaatccc ctggccgaca agctccttgt tgctgtcatg 3242581 ctttgagccc ttcatgttat cagcgaccat tgcggacaaa atcgactcaa gtcctccaag 3242641 aagcgcgatg acaagcgcag ccggaaacag cataaccatt ttatccaaag taagctcagg 3242701 aaactgaaat tccggcaaat ggcgggggat ttctccataa gttgacccga tcgttgccat 3242761 gcggtcaggg aaaaagacaa ccgcgaccac tgtggaaata agaagcgcca acaaagcgcc 3242821 cggcacttta ggcatcacct tggcggatac aagcaaaatg acgagcccga tcacagctgt 3242881 caaaatggca tacacgttaa aggtgccgag ctgctgcaca atttcaaaca tgttgtgatg 3242941 aaagttctca tgtttttcaa catttctcaa tccgagaaaa ttagcgattt gttccgtaaa 3243001 gatcagcacg gcaattccgg ctgtaaaacc gacgataacg ggtttgggca cgaatttcat 3243061 tatttttccg agcttaaaca gcccaaacag taccagcatc actcctgcca taaaccccgc 3243121 aatcagcaga ttttccaagc cgtactgcat gataatgccg aataaaatcg ggacaaaggc 3243181 gcccgtcgga ccgccaatct gatattttga tcctccaaac aaagaaatac aaatccctgc 3243241 tataacaaca gtgtatagcc catattcagg ctcgactccc gaggcaatgg caaacgccat 3243301 tcctaaagga attgccacga cacctactac gatacctgca atcaagtctt tctgaaattt 3243361 ctgcaaattg tatcccttga atctccctga gaatcgcata ttttgttata acctccctta 3243421 tgagtgattg tttataagct cagtttcata accgttaatg accacatcaa gttttcctgt 3243481 ttcagggtga atgacaagcc cgtgaaccgg cacttttttc ggaagcagcg gatggttctt 3243541 aatcatgttc acactgtggg aaacgctttc ttccacgctg tgaaaaccag tcagccacgt 3243601 tttcaaatcg agtccggcac tcgtcagcaa attcaggcag ctatcctcca ccccgcgttc 3243661 ctttgctttc tcaagaatcg aggacgcatt cagccctgac attccgcatt catgatggcc 3243721 gacaatgcat acctcttcag cctgcaattc ataaatcgcg accagtatgc ttcgcatcac 3243781 gcttccaaat gggtgagaaa cgatggctcc cgcgtttttt acaattttag catcaccgtt 3243841 tttaagcccc attgcttgcg gaagaagttc tgtaagcctt gtatccatac aggtgacaat 3243901 gacgagcttt ttcgaaggaa actttgtcgt tttgtacggt tcatacttct tctcactgac 3243961 aaaccgctga ttgtgttcca aaattgatgt taaagaaacc atttgattca tctcccatcc 3244021 atatgatttt gcaagccttc ttacccagct tacagtaagg aattatagca taggaataag 3244081 ccaagaaaag gttttcaaaa aaagacacta taattggact gtagaatcaa aacataaaca 3244141 tttatatctt tcaaagataa taaaatttat atttaatgca tcctataatc cggctgcagt 3244201 tcgtatatcg atgatttgtc tgacaaaaaa tatgggtgaa ttctgataat taaaaaactt 3244261 ttttaagcag atttagctgt tcgatcttca ttttaagttc aaaagaacca gaaattaaaa 3244321 aaacgcagct atatttttaa catctattta ttttcgatat aatgaattag acaacagcca 3244381 taaaggggga gccttgttga aaccatttgt atttatcaca aaaccgattc ctgaagagat 3244441 tgaagcattc atcggtgaac attgccgtta tgaagtatgg caggaggata cgcttccgag 3244501 tgacgtgcta tttgaaaaat taaaagaagc ggaggggctt ttaacatcag ggacgtccgg 3244561 accgtcaatc aatcgtgagt tgctggaaca cgcgcctaag ctcaaagtgg tcagcaacca 3244621 atcagtaggc tacgataact tcgatataga agcaatgaaa gaaagaggag tcgtcgggac 3244681 tcatacacct tatacactgg atgacacagt tgcagatctg gctttttcac tgattctgtc 3244741 ttccgccaga cgtgttgccg aactggaccg ttttgtcaga gcaggaaaat ggggaaccgt 3244801 ggaagaggaa gcgcttttcg gaattgatgt tcatcatcaa acgttaggca ttatcggcat 3244861 gggcagaatt ggagaacaag cagcgagacg cgccaaattt ggttttgata tggaagtgct 3244921 ttatcataac cgacatcgca aacaagaaac agaagacagc atcggcgtta agtatgcaga 3244981 gcttgataca ttgctggagc aatctgattt tattcttctc attacgccgc tgactgatga 3245041 aacctatcac atgataggag aacgcgaatt taagttgatg aagaattcag caattttcgt 3245101 caatatttcc cggggaaaga cagttgatga aaaagcactg attcgcgctc ttcaggaagg 3245161 ctggatcagg ggagccggct tagatgtata cgaaaaagag cctgtcaccc aagataatcc 3245221 gctcctgcag ctggataatg tcacgctgct tcctcatatc ggttcagcaa cagctaaagt 3245281 gcgcttcaac atgtgcaaac aggccgccga aaatatgctc gcagcgatcc aagggcaaac 3245341 accgaaaaat cttacaagag aatttcaata aatcaaaaat ccggtctgat aacagaccgg 3245401 atttcatatt acatacgctg aagaacagca cgcttataaa tatgacgggt gacgatataa 3245461 taaagagcct ggaatacaaa ataaatgaag atgacaatta cggcctcaag aaataaattg 3245521 gaattcagca tattacttaa cgctgcatac gcaaagcccg cgtgaatcgt acctgcgata 3245581 aatgggatga agaataaaaa tcctatttgc tttccaagga tcgagtgaat ctctttgtcc 3245641 gtaaccccta tcctctttaa cgctaacacc tgcactcccg tatcttctat ttccgtaaac 3245701 atccgcaaat acagcatgct tccttgcacg ataaaaaaca gcacgctgac aaacagacca 3245761 ataaacagca ttaatgcaac tccctgcttc acaatttgat aactaggagc acgtgtttga 3245821 aaatcagatg tatgttcttt cggcaccatg ttttcaagct tttcagagac atccaccgtc 3245881 tcctgccaat gctcaagctc ataacctacc attctcatct gttccttcag cggcacatcc 3245941 tgtgacagac tgtcaaagct cttttcgctg acaaccaata aacggctgac tccatcgaca 3246001 gacatcaata tccctttgtt ttgctgcttt ttcatgacat aggaaagggt ttttcctgac 3246061 ttcatatgaa atgctgctgt ttccccttct ccaaatgtgt ctttcaccat catttgaaaa 3246121 gaaacattaa taaatgcttc attttcttgt aaatgaataa ctgggaaccc tttttccttt 3246181 gcgacttgat tatagacttt ttctgaaatc agcaaagctt cagcttccat cttcttattt 3246241 ccatacggca agtctgactg aaaagtgaca ggaatccctg tggcatccac cttatacgtg 3246301 ataacagcat gagctttttt caatgtattc tcagccgtct caggcttcat gacctgaaag 3246361 cgggaagcat ccttttccac ccaggaaaca gactgaggaa tgctttgctc ctcctgcctt 3246421 tgtaaatcgg aataaaacat atagatgaca cctgtagctg ttagtatgac cgctgtaatg 3246481 acagaggtta aaaacagcat gcgtgcatga tccttcagcc tgaatatcat gttggaacgc 3246541 acaatgatat ttgtgccttt gtagaagctg tgtttctttc ggtacagcat gcggaaaaat 3246601 gccacactgc tttgggtaaa aaagaaatac gtgccaatta acactaaaat caaaattgga 3246661 aaaacccgaa acatcatgtc aattgcattg gctgttgcag atagataata accgctgcca 3246721 agacatagca aagacaatac agtgagccat ttcgaataaa ctggcaaact tttcggcttt 3246781 ttggctgatt taatcagttc aatgatttcc agcttccgaa tccgtcccag tgataaaatg 3246841 agcagcgtct gaaacaggat gagaaagccg gcaattgtca tcacaaacgc tttcggcaca 3246901 atggcaaacg aaatcggcac cttcacgctg agcatccatg tcatgatcat aaaaaacagt 3246961 tttgaaaata acaggcctgc tccaatgccg gccgcaatcg ccgcaagaga aataagtgac 3247021 tgctcataat aaatcatctt gcgaagctgc tgctttgatg tgccaaacag tgtcagcagc 3247081 ccaaactctt tctttcttgc ctgcaaaaac gctgaattgg aatatgtgat gaaaaatata 3247141 caaaacacaa tgatgacgac aagagctgcg ctcaagcatg ttttgacaag gcttcctcca 3247201 tatatattgt cttcattgac atcaggatga aaaataaatg atgtgaagac aaaaaacacc 3247261 gaaacggcaa acacacagct taaaaagtag gccacatacc gttgcagatt cccaagaatg 3247321 tttttacggg cgatagttct caaattcatg aaaatcgcct cccaacacac tcaaggtatc 3247381 caatatactt tgataaaaca cctgcctgtt tgttcctctg tgaatctctg aaaagaaacg 3247441 tccgtcttta ataaaaacaa tccgtttaca gaaacttgct gctgtggcat catgcgtaac 3247501 caacaaaatc gtcgcttcct tttcctcatt cagctgagcc agtgtgttca tcacttgctt 3247561 tgccgatttt gagtcgaggt ttcctgtcgg ttcatcggca agaatgagcg ccggattgtg 3247621 aataatcgct ctggcacaag ctgcccgctg ctgctgtccg cccgacacct catatgtgcg 3247681 gtgatcgaga atatgcttta tttgcagcgt atccgccagt tcatccaatc gagcttccat 3247741 ttctctcagc tttaccttat ccaatgcgag cggcaagaga atattttcac gaatcgtcag 3247801 cgtatcaagc agattaaaat cctgaaagac gaagccgagt tctcttctgc gaaacaaagc 3247861 cagctcttgg tcctttaacg ttttcggctg aatgccgttg atcatcatct cgccctgggt 3247921 cggcttatca atggtagcca gcaaattcaa aagcgtggtt tttccgcttc ccgacggccc 3247981 cataatcccg acaaattctc cttttgacac actgagatca aaggcgctga gcgcttggta 3248041 tgatattgtt cctttatttg aatagtatgt tttcgatagg ttcgttgttt gcaacacgtt 3248101 catgttctgc tcctcctttt tctttattat aaaaaggaag tcagcatcct cccatcgaac 3248161 tttcttgcaa ttccgctccc caatcttaca atgctgtcac attcacgagg gtgtcacttg 3248221 aaaacacgat ggtcatcaca gtgccagccc cttcttttga ttccgcatac agcttatggc 3248281 cgagacggct gcacacctgt tttgctaaat aaaggcccat tccagttgcc tctttcatgg 3248341 ttcgtccgtt ttctccggta aaaaacgcgt caaaaatccg cggcagatcc tgcggcggta 3248401 tgccgattcc ttcgtcggca accgacaagc gcgtctcatg tccctgtgtt tcaatccgga 3248461 ttgtaatagg gtctcccaca ccttgctttg aatattttaa ggcgttgaaa aggatttgct 3248521 caacaacaaa ggaaagccac ttttgatcac tggaaatctg aacggcattt ggcggcacat 3248581 gtaatgttgg aaaaaggcgc cgcttgataa actgacgttt ttcctgattg atcagtgaac 3248641 gaaccatttc tgccaaatca aaggtttgcg gctttacatc aaatgcaaat tcctccagcc 3248701 gggccgtttg cagcatcata tcaagaccgt ggcgaaatct ctcattctca tcctccagct 3248761 cctctaaaaa cgtcggaaaa gaggatgagg ttccgttttt tccttcctga atcattaagg 3248821 atatgacaga taccggtgtt ttcatatggt ggacccattg gttggtgaag gtgtaatgct 3248881 gtttttgctg attgatatat tgtgagagcc tgctttcgta ttgctgcccg agtgcgttga 3248941 tcatcttcgt ccaaagcgct tgctctcctg ttcttggctt tctggctttc aaagactgtc 3249001 cgatgtcatt cgaagaagag gcttgttctg caagcttttt aacatatgtg agaaaggaaa 3249061 attgccgaac ataatcagca gcaaaacctg cggctaaaag agtaccgggc aaaatccata 3249121 tgtacatcat attttctttg gaaggttctg cgccgctctc tacaatgctt aaatacgcaa 3249181 tcagcatggc ggaccctatc cctaataatg aaaatagaat aatggctaag cggtcgatga 3249241 gataagtctt taacattccg cttcatcctt ccgattgact tgaaattgat aaccttgtcc 3249301 tctgattgtg gaaatgcaat ctgtcagtcc tgcattctcc agttttctcc gcagccgatt 3249361 gacattgacc gttaacgtat tgtcatcgac aaaatcaacg tcatcccata acgcctccaa 3249421 tagttcatca cgagagacaa tttttttatg ctccctcaca aaaatcgaga gaagctggaa 3249481 ttctttttgg gaaaacaaaa tccggacgct gttccattcg gcctcattct gatcaggata 3249541 aatcgtcagc ccgccaagct ccactattct agattcctgc ggcaaagagg gcgaatattc 3249601 accatatgtg cggcgcagga cgcttttgat tttggccatc actacctcta gatggaacgg 3249661 ctttgtgata taatcatcgc cgccattttc aatcgccatt acctgattca gctcatcggt 3249721 ccgtgccgat ataaagataa tcggcgcatt ggaaatggta cggatttgcc tgcaccaata 3249781 aaacccgtca aaaaaaggca ggttgatatc aagcagcaca agatcaggct tcatttctgc 3249841 aaattccaat tttatatcat tcagctgttc agcaattttc acttcatatc cgtatttttg 3249901 aagatgaccg cccagcaaag aagcaatccg ctcatcatct tccacaagca aaatccgata 3249961 cacgttgatc ccccttatat gtacatcacg atgatttttc tagaagattc caaaattatt 3250021 atagcatgtg cggaatagta aatcggtctt tttctttttg ttatgataga atgataaagg 3250081 taaaattttc ataataggca ggtgtcgtga tgaagaaaat catgctgttt ctggcaatga 3250141 cgtcaattct ttcagcatgt cagcccaact ataccgggaa atacatagaa attggggata 3250201 cactaactga ctataccaaa gagtgcttta aagagaatga aattccttat aaatacgaaa 3250261 agggaaaact gtatatccca gaagacgcat ttgatacagc aatctacact tgttcataag 3250321 aaaaagcttg cagataacct gcaagctttt cacgttacaa aaaatgagta tttaatttct 3250381 cttcaaatcc tgaagggccg atgtcgcttt tttgaatgtt accgccgttt tcataaatcg 3250441 taaaatggcg ctctgacatg accatccttc cgctcggcgt cagctttgag gcaagcaggg 3250501 atttgttaaa aggagatttt tcatgagagt gaatgatgtc cttcatgtta tctaaatcac 3250561 cgagatcact ctcttcaagg gtaaaggcgt acccaatttg ccagccttct cctttgtcca 3250621 tcagcagaac atagctgccc ttttctgtct cttccttttt gattcggaat gacccgactg 3250681 gtgactgtac cgtttctccg gaaagcggta tcggctggag cgccaggttg atgccgaagc 3250741 cgatatcaac gaggtaatcg ccgttttccg cagacagcca tacagcagca tgcgtccctt 3250801 ctagtgccca tccctcttga tcgcctgcat aaaccgttcc tcgaatgagc ttcacatgaa 3250861 acccggcctc acgcaagaca aaataaagga aaccatttag atcgtagcat aggccgccgt 3250921 gctgatcttt gagcagacgt cgccatagct cttcttttgt gatcttataa ttctcttttg 3250981 caagtacggc acggttttcg aatggaaaac ggtatgccat tgctttaaga aaaaggggaa 3251041 gatcgccgaa gctgacatgg tctttctccc agccgatttt ctgaaagcag tcttttagaa 3251101 agtcactcat ttttatcacc taaacttctt cttgaacgta agcagccagc ttctccagcg 3251161 cctcttgttc atcttctccc tgggcaatca aggtaacctc agtgcctgtg cttaccgcaa 3251221 ggctcatcag ccccatgatg cttttggcgt ttactttttt cccatccttc tcaagaaaca 3251281 catctgacgt aaaccggttt gcttcttgta caaacaaagc agcaggacgt gcttgcagtc 3251341 ctgtctttaa tcgaacttcc actttctgtt gaaccataag atctcccctt ttctttacgg 3251401 ttattttaaa gtgacggttt gccctgtccg cagctgttct gcgatttcgt caagttttct 3251461 cagcctgtga ttgatccctg atttgctgat tttcccgctt gctaccattt cccctagctc 3251521 tttcagcgtc acttcctgat aatcaatccg cagctgcgca atttcccgaa gtttttcagg 3251581 cagcgcctcc aggccgattc tttcatcgat gtatttaata ttttccacct gtctcagcga 3251641 tgcgccgatc gttttgttta agttggctgt ttcacaattg acgaggcggt tgaccgaatt 3251701 tctcatgtcc cgaacgattc tgacatcctc aaatcgcaga agcgaattgt gagcgccaat 3251761 tacgttcaga aactctgtaa tcttttcagc ctcttttaaa taggtaatat agcctttttt 3251821 ccgttcaagc gttttgctgt ttaactgaaa ctcatttaac aggtcacata atgaatcgtt 3251881 atgctcctta taaagagaga agatttctaa atgatacgag gaggtttccg ggttattgac 3251941 cgaacctcct gccaaaaatg ctcctctcat ataagaacgc ttgcagcatc tctttttgac 3252001 cagctctttc gaaatacttc gttcaaacac aaaattctcc ccgagtattt ttaaatcctc 3252061 taagatcgct tttgcatttt ctgaaaaacg cacaatatag acgttattct ttttcagccg 3252121 cattttcttt ctgaccagca gctcgaccga cacatcatat tgttttttca gcaatgtata 3252181 gatgcggcgg gcaatcgccg cgttttcggt ttgaacatcg agtacgagat ggcggtttgt 3252241 aaatgataaa gctccattca tccgaatgag tgcagacagc tcggcattaa tgcagcagtc 3252301 cttcacttcc agattcgtta attctttttt tgtttctgat gcaaatgaca tatagccacc 3252361 tcatttcaag gcttcattct ttcagtaaat caacaagaag agaggccact ttatgtgtat 3252421 cgtgacgtat tacgtcattt ttatacgtta caatttgatc tctgatgact tcaagcccca 3252481 tcgctttcag ctcttcgata tcaaaatcaa caggacgcgc cgattccatt tcgtacttac 3252541 gttttatttc gtcgggaatg tcttcactgt tcactaatat cgtatcaata aaaccacagc 3252601 ccatatgctg attgagcgct ttcacatgat cagcagcggt gtaatggagc gtttcgccgg 3252661 gctgagtcat cacgttgcaa atgtatactt ttttcgccgg cgcctttatc acttcttccc 3252721 cgatttttgg gacgagcaaa ttgggaagaa tgctggtata gaggcttccc gggccgataa 3252781 taatcaaatc cgcttccctg attacgtcta ttgtttccgg cagcggatca atctgttcag 3252841 gcgtgagaaa aacacgctta atgcgctgtc cgtattctgg gatcgttgac tcgcctgaga 3252901 ccacgcggcc atcttccatc tcagcatgca aaacgacact ggcattggca gccggcaaaa 3252961 cctttcctct tacattcagc accttgctca tttctgtgac agcgtgaaaa aaatcaccgg 3253021 ttatatttgt catcgctgcc aaaatcaaat tcccgagaga atggcctgtt aagtcattcc 3253081 ctttattgaa gcggtgctga aaaagatctt caacaagcgg ctccacatcg gataaagcgg 3253141 caagcacatt tctgatgtct ccgggaggcg gaattttcag ttcattccgc agacggccag 3253201 agctcccccc atcatcggca actgttacaa tggccgtgat gtcaacgggt ttatgcttta 3253261 ggccccgaag caatacagaa agacctgtac cgccgccaaa gattgcgatt ttcggctttt 3253321 gtcccatctt atttccggct tctcttttca atgtcccggt gagtaacatg agtatagtaa 3253381 tcctttttga aataatcagc taaattctcg gctaatgtca cagagcggtg ctggccccct 3253441 gtgcagccga tcgcaatgac aacctggctt tttccttctc ttttgtaaga tggaagcata 3253501 aagctcagca gatcaattaa tttctcattg aacttttgcg tttcattcca cttcatgacg 3253561 taagaggaaa cctctttatc cttgccagtc agcggccgca tgctttcgat atagtacgga 3253621 ttcggcaaaa atctgacatc aaagacgaga tctgcatcaa ttggaatacc gtatttaaaa 3253681 ccaaatgaca tcacatttac ggtaaatgtc tctccttggt ttgtcgcaaa gtgcttcacg 3253741 attttttcac gcaaatcacg cggcttcatg tcagacgtat cgtaaatgat ttgagagcgg 3253801 ccttttaatt cctcaagcag ctctcgttct agcgcgatgc cttcaagcgg caggccagtc 3253861 gctgccagcg gatgcgagcg tctcgtttct ttatatcttg tgacgagaat ggaatccttc 3253921 gcgtccagga ataaaattcg cggtgtgatc cacggatttt cggccatttc atccagcgct 3253981 tcaatcagcc ggtcaaaaaa ttcgcggccg cgcaaatcca tcacgagcgc aactttgctc 3254041 attttcgaat ttgattcctt catcagctct aaaaacttcg gaagcaatga aggcggaaga 3254101 ttatcgacgc agaaatagcc gagatcttca aagctttgga tcgcgacagt tttccccgct 3254161 cccgacattc cagttataat gacaagctga atatcatgtg attcactaac actcatcttt 3254221 ctcccccctg acttgtcttt ctatttgatg tgctgcgggt ctaaacgata actgagcagc 3254281 tcaaattccg gtgtatacgt aaatgtgccg tgcagcagcc cttgtccctt catcataaaa 3254341 tcaaggatat ggccgtctcc aggggccata ggcaggttct gaatgtcatt gacatcgtgc 3254401 cactgcagtt tgccttcctc tgattctgat acattttgtc ctgtatatga atcagcgaca 3254461 aacgtaaaca tcatccactc ggagacaatg tggtcaccgt ctttaataat aaaggtaaaa 3254521 acgcctttta attgaggatt tatgatatag ataccagtct cttctctgta ctctctgatg 3254581 acggagtctc tgactgattc tccgctctcc atcttgcctc ccggcgcgac ccaccatccg 3254641 cgtctcggct tttgaagcag aagaactttg tcatccgtct gaagcacaca atttgtcact 3254701 ctttgcaagt acgtcaccta accttcgtcc tgtcatcgtc tctttattat accgcttcaa 3254761 gatgcctccc acaatgaaga gacattgaca atcttttctt ctattttaca gcatattcat 3254821 tccttaattc agatgatttt gctgtaactg gaattctctt ttatttatgg acaaaaaaag 3254881 gacacggata actggagaat ccgtgccaaa aaagtgtatt cattataaaa agggggtcaa 3254941 ttactttatt aatcataacc gaaaagcatt acacatgtgt tacagcggaa ttaaaaccca 3255001 gtaacgtaat gtgaaactcg tatgacagcc ctttttattt taaggttttc agcgtttctt 3255061 ggagctcttc gacataatgt tgtacgcttt gtgccgcaat gcttccgtct cctgtagccg 3255121 ttacgatttg gcgcagtgat ttttcgcgga tgtctccggc agcgaaaatc ccttcaacct 3255181 tagtttccat gcggtcgttt gtttcgatat agccttcttc attcgtaatg cccaggtttt 3255241 caaacggttt agacagagga agcatgccga tgtaaatgaa tacgccgtct gttttgaatt 3255301 cactttcttc accggttacc gtatcgacaa gcgttacgtt accgactttg ccgttttcct 3255361 catgaatttc cttcacagtt ttgttccata ggaagtcaac tttttcatta tcaaatgctc 3255421 tcgcttgaag aatactttga gcacggagtt tatcacgtct gtgaacaatc gttacttttg 3255481 aagcgaaacg agtcagatat acgccttctt caaccgcgga atctccgccg ccaacaacga 3255541 caagttcttt gcctttaaag aaagcgccgt cacatactgc acaataagat acaccgcgtc 3255601 cgcccaattc tttttcgcca ggcacgccga tttttttata ttccgcacct gcagcaatga 3255661 tgacagcacg ggctttatat tcctttgaac cagctttgac tactttgtac tctttgccgt 3255721 caatgacctc tttaatatcg ccataagcgt attcagcgcc gaattttttc gcgtgttcaa 3255781 acattttgtt agaaagctca ggcccaagga tactttcgaa tccaggatag ttttctacat 3255841 cttccgtatt ggccatttgt ccgccaggaa ttcctctttc aatcattaat gtcgataaat 3255901 tcgctcttga tgtgtataca gcggccgtca tcccagcagg gcccgcgccg attataatca 3255961 cgtcataaat tttttcttct gacacactat tcactcctta aaccatcttt tcaagtttgg 3256021 gctctttctt ataagataag aatccccatc aaacgtattc cttacccata tcctataaaa 3256081 tctcatggtg atacgctatt tttttgctca acacgattaa atgtattcga aaagggtata 3256141 tgttaataaa gaaagagcct tctgtttata gaaggccctt gtcatattta ttattgaaca 3256201 acacgtctta caacaccttt aaatgctgct ttccagtaag gattgctcat agagtcaaca 3256261 gatacgccat gagatgtatt gtcgtttagg aaagtaccgt ttcctaagta gattcctacg 3256321 tgtccatttg ttttgtaagt gtcaaagaac acaaggtctc cgcgtttcat ttcagacgcg 3256381 ctgacagctt gtcctctgcc aactaacgta tcagttgttg ttccgcctac aggtccaagg 3256441 ttaacacctg cagaagcgta tgcccagcgt acgaatgatg agcagtcaaa aatacggttg 3256501 ttgatatcag actgagtgcg tccgccgcca aacttgtacg gagattgtcc tacaatgctt 3256561 gaaccaacgc tgatcgcgcc ttcaattccg ccagagttgc tgataacagt gccgcctgaa 3256621 ttgctgtttg agccgctgct cttcttagaa gatgagccgt ttgacgaact gtttgatgaa 3256681 ccgttagaag aattgtctga agaattgtct gaagaatcat cagatgagct tgcttttgat 3256741 gattcagttg tcgccgtttg actgtcatct gtttgtgttt catcagatgc tttttgtgct 3256801 tcttcctgct ttttgatcaa agcagccgct gcttcttgtt cttttttgat gcgtgcttgt 3256861 tcagcttcag tatttgcttt ttgatttgca agttcagacg cctctgattt taattcagaa 3256921 atcgctttag ccgttttctt ttggcttgct tttgcttcgt cgaaaagctt gtctttttca 3256981 ttaagctgtt tatcaaggtc tttttgcatt gtttctaatt tagccaaggc agcttgaact 3257041 tctttcagct tgtcattcaa atccgcttca gaatcttcga gcttcgcttt atcctgctct 3257101 tgctgtttga ttaaatcttt gtctgcgtcc acaatagatg aaaccgcagt cgcacgagag 3257161 ataaagtcac caaagcttgt tgatcctaaa agaacatcta tgtatccttg agatccgccg 3257221 ctttcctgta aagaacgaac gcgttttttc aggatttcat tgcgtttttc gatgcgtgct 3257281 tcagtttctt taatctcttt tttcagtttt ttgatttctt cttttgtttt atcgttttct 3257341 tcttttttat cttcaatctt gttgcttgta tcaagcgcct tatcgttaat gtctttcagt 3257401 tctttttcaa tctttgattg attttcctga agctcggtta attctttttc cttcgcttca 3257461 atgctggaag caacctcaga ttgcttgctt tcgatttttt gtttcttttc atctaatgtt 3257521 tccgccgatg cagttttact tgtaaatggg atcaaaaaac tgcttgtccc gatgacggaa 3257581 gccaaaccaa gtgtaattaa actctttctc actttttata tcctcccttt tactgtgaac 3257641 ctgtcctcat ttggaatcgt attttgaaca tcaagtttcg ttcctcatac tctacgagga 3257701 atgatggttg tttatggtta attattctgt gcatctctta ttctggttgt atagcgttta 3257761 tttcacatca tatgtaaaaa acactaattc cttatgtacg agaatcatta taccatcaag 3257821 tttcgacaaa ttagcgataa attttattac atttatgttt caaacagatg tcaagtcaca 3257881 catcatttgt catttttctt aagcgtgtaa aaaaactgtc gatattattt tcttaatata 3257941 atctatctaa caaaaaaaga gtcgattaaa taaatcaact ctttaaaatt tactattcta 3258001 gaatatcatc aatatatttc atatatttcg tcaaagttgc cggagagatg ccgaatcggg 3258061 ccgctgtgtc ttttttcgtg tcttgcttgc catgggcttc tttccaaata taacagatgg 3258121 ctgctgccca gcctttctca ttcttcaacg gagcagctgc acgaatttgc tggatgacat 3258181 gaaaaaccca gcagctcatg acttctgttt tcatctcttc tttttcagct tgctctaata 3258241 gtttgaccgt ttgataagcg aaaagtgcat cctctgaaac gtcagcagcc gcagaatctc 3258301 cattcagaag cagctttaca aaatgagttt caaaaggagc ggtaattctc tttgagcgta 3258361 tcaccgcttc aagatgctct gtttctccct ttgtgctgct gatataatag gctgcgagtc 3258421 gctgctccac agatgaagga agagcttccc tccgctcaat ccaaggcgcc gggcggtctt 3258481 cgccgggata ttgcgactcg acttttctcc agatcgtctc ggcaaagtcg gtatgtcccg 3258541 taaaataagc agagcaggaa agccagtaaa agaaggtgtc gtcaccctca aagccggttt 3258601 tatataatga tttgagccat ttatatccga tctcgtagcg gccgacaagc gccaaagtag 3258661 cacccaattt ataacgctgc tccaatagca tcggatagac attggagagc tgatcactca 3258721 attccgccac tttttcgtct tctctttcat aatagtagaa aacgagaaga ttgcataagg 3258781 cgtgaagatt tccttcatta tgagaaagca cttcataagc ggtttgcttc gcttttacaa 3258841 cgtttcctga atagaaatag gcaagcgcga gattgttgta tgctgaccaa agctccggat 3258901 attcagttgt gatttcctca agcgccgcaa ccgcttcagc aagctggccg ctttccagca 3258961 atgactttgc ccgatcctgt ttcaccagca gttcatcctg atcatacaac gaatcctcaa 3259021 tgccgtcgtc tcctaaatcg agcaaatcaa gcagactatc gttttcttcg gcgaattcac 3259081 catccgggtc cgcatcagaa taagcggccg cttctttata agcttcctgg aagagcccca 3259141 gatgggcaaa gttattcgct ttaaagtaat ggcactccgg catttcggcc tccagatttg 3259201 ccatgatata gtcaagaaga tcgttcgact cttgatactg gcccatttcc gaataaatga 3259261 ccgcaagctg tgaaagcatc tctgaatcct ccggctccaa atgaaccgcg cgctgaatca 3259321 gtttgcttgc ccgttttaga ttgcgctctt tatacgcttt caagccttta tgaaaaaaat 3259381 attgtccatc ttgaagcagc tggacaattt gtgcgtgatt tttatgttca gaagtgtgtt 3259441 ttcccacaac taccctccgt tttatacaat attaccgtca gtagtatacc ataaatcgta 3259501 agcccctcaa tagttcaaaa ggaaggattg ggaaaatccc tcctcttttt tattggctga 3259561 ttcgaccaaa atttacccgg ctttgttttc taagtccgca ttcattttca gctgctgttc 3259621 agcaaaatcc cggtaaaggc catgggaagc cattaactca tggtgtgttc cacgaccggt 3259681 aatttcccct ttttcaacaa acaaaagctg gtccgcatct acaacggtag ataggcggtg 3259741 agcgataaca atcgttgtgc ggccctccat cagcacctcc agcgcctgct gaactgattt 3259801 ttcagattgg ctgtcgagac ttgaggtagc ttcatcgagc ataagaatgc ttgggttacg 3259861 gagaagcgct ctcgcaatcg cgattctttg cctttgtccg cctgacagca taatgccgcg 3259921 ttcgcccact tctgtatcaa actgattcgg cagctccttt ataaaattga gcgcatatgc 3259981 catctccgcg gctttttcga tctcagcatc cgtcacatct cgttctaacc cgtagcaaat 3260041 attttctctg attgtcccgg acattaacgg gctttcctgt gatacatacc cgatatgctc 3260101 cctccacgat tcaagcgagt aagtatcgac cggctcgtcc cccagccgaa tggtccctgc 3260161 agtcggagaa taaaagcgtt caagcagctt aaacagcgtc gtttttcccc cgccgctcgg 3260221 accgacgatc gctgtcactt tccctgcttc aatgacggcg ctgacctctt ttaagatcag 3260281 ctgatcaggc ttatatccaa aagacacgcg atcaagctgg ataggcagat gtgcattttc 3260341 aatttgtttt cctgtcactg tatcttcctc ttcctctgcc aaaatctcaa tcattcgttc 3260401 tgttgcaccg attgattttt gcagctgtgt gaaaaacgtt gtaatctggc ccatcggcat 3260461 aataatttga aacaaatata aaataaaagc cacgagcgct ccggctgtga gctcgcctga 3260521 tgagacctgc atgccgccat atccgatcac tgcgacaagc gctgccatta acacgagtga 3260581 aataagcggg ccgacaagcg attgaacctt ggcttcacga acgccaagct taaataatga 3260641 ggaaatcccc atcttcccgc gcccatattc gacatcctcc gcatttgaag ccttaacaag 3260701 tctgatttcc gggagaattt gattaagcag gcctgtaaaa cgagccgttt catcttgcgt 3260761 ttcccgtgaa atggagaaca ttttccgtcc aatcggcacc aaaataagag cggccagcgg 3260821 aacgaccact aacacaagca gtgtcagctt ccagttcata ataaacaaga ttgtcaatga 3260881 tccaatgaca gaaatgatgc ctgtaataaa tccgctgata tgggttgtaa tcaattcttt 3260941 gaccaccatc gtatcgttcg ttacacggct gactgtttct ccggaagcat ttgtatcgaa 3261001 ataagagaca ggcagcttaa ttaatttctt ccataataac tcccgcagcc cggaaatgat 3261061 tttttgtcca ttatagttaa gcgcataggt ggcataagcg cttaaacccg cctgaacgaa 3261121 aaacaccagc gcgatcaaac cgatttgcgt gcctgacaga tttgacatag aaaaaccatc 3261181 gacaagctgc ttcgttaata atggaatgag caggctgacc agcgtggtta ctacactgag 3261241 ggcaagcgca aaggcgagct ttccataaga aggattggtc cgtcttacta aggcaaaaaa 3261301 gggtttcaat ttacttttag atttttgttt cttggttggc atatattttc ctcctgtttc 3261361 agcgttcaga aaggtgaaaa gtcatagcaa aaggatgatt tttactcttt ctcaatcata 3261421 tcaatggaga aagacttttt cagtatattt ttgccgtgat caaaataaaa atctcccact 3261481 cattgtttga ataggagatt tttgtgttag acatctttca ctggcttctt ttttctgtaa 3261541 gtcaatgtta catcctgctg tcgcaggtct tctattatca ttttgtaccg atcaactttt 3261601 gcggtatgtt cttcttttat catctgaagg gcagcttttc gtttttcgct attagactca 3261661 agctcttttt ttattttttt tacaatcaac cctttttgcc ctttgatttc ctcttttaat 3261721 gaagactcaa atttctttgt caggctgaga aagtcgttga tcggttgatt gagggtgccc 3261781 gctttcccct tcatttcatc ttgggtaaga aacatatagg tcgttgatac aatttctgtt 3261841 tcactttctg aaaataagga agtcactctt catattcctc ctaagactga aaatcaaata 3261901 actgagaaat catttcttct ttttcaaaca gcttttcaat actctcgcgg atatttttga 3261961 taaaatctct tttttctgtt gtctgttttt ttaattcagc aacaattcca tcatttgcag 3262021 gaagcgcacc tgtgtggaat gattcatgaa ctgagatttt ctccaattta tcgaatgtgt 3262081 ggctgaaacc agctgcaagc cggaattgaa gatcgaaggc ataatgcgaa gggttttctt 3262141 ccatatgatg aatagccgtg atgatcgcct gctttttgtc tatgaagtct tcatcgattt 3262201 cctgactgta aaccttctgg tacttagaaa tcgcatcttc catatcttca acgattttca 3262261 taccgttttg atagattctg acagcggatg agagattgac ttgaatcgtt tctcccgagc 3262321 cactcttccc tgtaaaataa atatcggagc ctttatagct gaagcctttt tcctttgaca 3262381 aggcgttgag catttgaacg atgctgtggc cgtcgacgat aagttttagt gcgtcttttg 3262441 tttctgtgtc gagtgttttc aatgaggaca gaattgattt tacatagtcc actatttcac 3262501 caacgtcttt taaagcttgc ataaattggc catgttttag atggtctatg aaatgttcgt 3262561 accgtgactc tatgcctcgc atactcgcat taatattcgt taattctttt ttgatgactt 3262621 tcttttgcgt ttcatcaata taaccatttt cagctaactg atctacgacc ggtccgctgt 3262681 ttctcaacaa ggtatgaaga aaacctaaaa acgacggcag ttcctctttt attcggccat 3262741 acatttgctt aacatcatca aaatgctcat ataggacact tactttcttt aaagcgccgt 3262801 ctgtgttttt cactttttca atcaggtcta tgtctatccc gctggctgcc tttataaaac 3262861 cgttcaagcc gtctttttca tagtcatcct tatatttttg aaggaatttt tgaattgacc 3262921 tcacatcttc gtcaggaacc ccatccataa tgtttcggat gccttttaca cttgtatttg 3262981 tatctgccat cttcacatca ccgaatgtaa taaaatcggc cttgccgctg actccataca 3263041 gcgggtcatc ttttgagatg cgctgagtga tgtttgttgt tacgcctttg tcttcataat 3263101 atttttggat ttcttttttt aacttttctg gcgggatgga atctatatct tcatatttat 3263161 aactaaattt cctaataaca tatctatata aactttcatc agtttcaagt aattgatcaa 3263221 tattgacttg agctccattt accccataaa cttcatcata ttctccatca atcaattgca 3263281 ccataacttg gttattattt gcaagtgaat gtcctaaggc gaatgttttt aaatcctcag 3263341 agttacctgc tgctttcttt gctttgttag taaactcctt tgtagcctca tactgactat 3263401 gatcaattcc taaaaaaaga ccaaaaaagt tatatgacca atccttatta tcggcactac 3263461 cttctgaaat aatctgaagc tgatcaatat gttttttctc atctattata tggattgccg 3263521 ttccatcgta acctgattct ctggtcgaac tttgtatact tgtattctga tttacaagtt 3263581 cattggaggt gtaaatttca attttcatat tctcaggaag atcgtggtgg gtttcctctt 3263641 tataaattct gcgtatatct gcttcgaaat ccttcttagc tttcttaact tcactcgcaa 3263701 tagttgaggc aaacttttgt ttatagtcat attctaaatc aattaacctt aactttacgt 3263761 tctcattctc aaatacattt ttatttccca tcttatttct cctttttatc tattaaaaag 3263821 gtgatagaat taattaattt ctcaacttta tttttagcct tttcttcatc taaggagcat 3263881 ggttgatttt catttttgca tccaagggta aaggcgtatt ctactcctag gttatcttcc 3263941 tctgtagact taacatatcc aaaataactg tatgaataat tatattttct atcaatatcg 3264001 tcaaagatgt cttttttctt ggcagtgtaa atatccgttt tctttttgct gctttttttg 3264061 tattcgcctt tataatcatt ttttccacta acaatatcta gcattgtctt aggttcattc 3264121 gcaaaacttt cttctttgta atatgttaca tggccatcaa acattacatt ggtgtcttta 3264181 tcataactat taaatccaat actttctttg tttttcccgg ttaacgatga tcttcttgat 3264241 agatactttc catcctccgg aaacaacatc ctaaaccctt tcagcttaga ttccagcaaa 3264301 taatatcctg gttcctcttc ttttgttgac accatgtact ctctcgtttt ctcgtcctga 3264361 aacgcaggta cttgaggcag atccttggga tccatgtctt ttggttttac cgcttctgtt 3264421 ttattgtcat ttgtgctgtt tttatcattg tcattcatac tgcatcctcc tgtcagggca 3264481 agtaataagc tgaagcaaat aaagatgatc tttttcatta cgaacctcca cgggttttgt 3264541 gagaatagta ttctattttt atatcaaaaa taattctatt gacctggtta agagatgatt 3264601 atttcatcct ttttcatgtt acatcatggc ggaatttgga taaataggaa atgagactcg 3264661 gttttgatct ccttttatta actaatcata tataacaccc aatataaatc taaataccta 3264721 ttactttttt cacaaaacaa aaagagccgt atcatccggc tctttactct tcaatctcag 3264781 aatggcgttt tttcaatacg tcaagcacat catccagcgg cagggattgt tctctgagca 3264841 ggacaagcag gtgatacagc aggtctgccg cttcccattt gagttcctca tgatcccggt 3264901 ttttcgcggc gatgatgact tcggatgctt cttctccgac ttttttcaaa atcttatcga 3264961 cgccttcacg gaagaggtac gtggtgtaag ctccttcagg catttccgct tggcgttccg 3265021 cgatcacccg ctccagttcg ttcatgatgc cgaatcggtc cgcggcctgt tcttctgttt 3265081 gttcctttgt aaaacagctg tagctgccag tgtggcatgc cgggcctgac ggttctacga 3265141 gtacgagcag cgcgtcttga tcgcagtcat accggatacc tttgacggct tgcgtgttcc 3265201 ctgaggtttc tcctttatgc cataacgctt ggcgtgagcg gctgtaaaac catgtttcct 3265261 tcgtttccag cgttttttcg tacgattcct tgttcatata cgcaagtgtc agcacttctt 3265321 tgcttgccgc atcctgcacg atagcaggaa ttaatccgtc ctcgttaaaa cgcagttcat 3265381 ctgcctgttt catctcacat tcaccccgta ctctttcaag tatgatttca cttctttaat 3265441 cgatgtttct ttataatgaa aaattgaggc ggccagcgcg gcgtcggctt ctccttttgt 3265501 aaaagcctca agcatatgct gtgcgtttcc cgcgcctccc gaagcgataa cagggacggg 3265561 gacagcttcg gaaacaagct ttgtcagcgt gtggtcgaaa ccttttttct caccgtcgga 3265621 gtccatgctt gtcagcaata tttctcctgc cccgcgtttg acgccttctt ttgcccacgc 3265681 ggtgacctcc caatctgttt tctttctgcc gccgtgcgtg tagaccttat atgtgtcaga 3265741 ttctttgtca tacttggcat caatggcaag tacgatgcat tgagaaccga aaaactcggc 3265801 tccttctgta atcagctcag ggcggagaac agctgccgtg ttcaccgaca ctttgtccgc 3265861 tccggcacgc agtatcgttt tcatatcgct gagctgattg atgccgccgc cgactgtaaa 3265921 cggaatggca agcttcgcgg caacctgctc cacaacgtca accatcgtct ttcgtccttc 3265981 gtgcgaggcg gagatatcaa gaaaaacaag ttcatccgca ccttcccggt cgtacacttc 3266041 ggcgagttca actgggtcac cggcatcctt caattcgaga aattgaattc ctttgacaac 3266101 gcgtccttct ttgacatcaa ggcatgggat aatccgtttt gtgatcattt gcgcttcacc 3266161 ctttcaagcg cctcactcag cgtaaactga ttggtataca gcgcttttcc gatgatcgct 3266221 ccagagacgc cgtccgcctc attgcgggcg agagcttcga gatccgcgac ggagctgact 3266281 ccgccggaag cgatcaccga tttccccgtt tccttagcaa gctcgaccgt gcttttaaca 3266341 ttggggcctg acagcattcc atctgtcgcg atgtcagtaa aaataaagac ttccgcacct 3266401 tcattggcta gctctttgcc cagttcagtt gccttaaggg ttgatgtttc aagccatccc 3266461 tctgttgaaa caaaaccgtt tctcgcatcc agtccgattg caattttctc gccatattgt 3266521 ttcagcattt ttttgacaaa cggagggtta gaaactgctg agcttcccag gatcacccgc 3266581 tcgactcctg ctgataaata ttcatagacg tcattttcag aacggatccc accgccgatt 3266641 tcgactttca ggttcagctt ttgcgcaatc tcaatcacat ggcggtcatt cactcttttc 3266701 ccttctttgg ccccgtcgag atcaacgaga tggatccatt cggcaccctc tttctcaaat 3266761 aactcagcca tgtcgtacgg tgaatcgcca tatatcgttt ccttattata atccccttga 3266821 acaaggcgaa cacatttgcc gtttctcata tcaattgccg gatataatgt aaaagcactc 3266881 attttttcac cttctgttct gctgccattt tcgtaaattg ggttaaaata gacattccga 3266941 ccgtgctgct tttttccgga tgaaattggg cgccgaagac gtttcttttt ccgactacag 3267001 caggcactcg tacaccataa tcggcgcttg ccagaagcgc gttctcctcc atcccgtcaa 3267061 tgtaatagga atgaacgaag taagcgtagc cttgttctgt tttagtcagc agcggagatt 3267121 cattatgaaa agaaagacga ttccagccca tatgcggaac cttcagcttg tttccttttt 3267181 catcttctgc tttcagcctg actgcttttc cttttaacag cccgagtcct gaagcggtgc 3267241 cgttttcttc gctttcttca aataaaagct gcatgccgag gcagatcccg agaagcagcc 3267301 ttccctctga gaccatatcg tgaatcaatt gatcaagctt cgtgtagccc aaattgtcca 3267361 tcgcgtctcc aaatgaaccg actcccggca aaatgaaagc atcagcttct ttcagctcct 3267421 ccggcttttc agaaacaaaa tacggcacgc cgacacgttc aagcgccttt gagacactgt 3267481 ataaattccc cattccgtaa tctatcacgc cgatcattta cagcatccct ttcgttgacg 3267541 gtattccttt aactcgcgga tcgatcgttg tcgcttcatc aagcgcacgt cccagtgctt 3267601 taaaaacggc ttcaatcatg tggtgggtat ttgttccata atgaacgatg acgtgcaggt 3267661 tcattcgagc ttcgagcgcc agcttccaca aaaattcatg tacaagctcc gtatcgaaag 3267721 ttccgacttt agcagccggg aaatcagcgc gcatttctaa gtgcggccgg ttgcttaaat 3267781 caatcacaac ttgagcaagt gcctcatcca tcggcacaaa cgccgatccg tagcgtttga 3267841 ttcctttttt atcgcccaac gcttcgagca gcgcctgccc taagcagatg ccgatatctt 3267901 cagtcgtgtg gtgatcatct atatcaacat cgccttttgc gttaatggaa agatcaaatt 3267961 ggccgtgttt cgtgaataaa tccaacatat gtgtcataaa cggcacatct gttttaatat 3268021 ccgcttgtcc tccgccgtct attgtaaatg ccagctcaat atctgtttcg tttgttttcc 3268081 tgacgcgttc cgcttttctc atttagaaat cctccgttct ctcgcttcaa ttgatctggc 3268141 atgggcttct aacccttcca gtctggcaaa agccgcgatg ctttcggcat gttcttcaaa 3268201 ggctgattga ctgtaagaaa taatgctcga tttcttttga aaatcagtta cgtttaatgg 3268261 acttgaaaat ctggctgttc cgtttgtcgg aagcacatgg ttcggtccgg caaaataatc 3268321 accgacaggc tcagggctgt atctgcctaa gaaaattgca cccgcatgtt tgatactgcc 3268381 aagcaaagct tccggagact gtgttatgat ttctaaatgc tctggcgcga gtgtattgac 3268441 agtctcaatc gcttctacca ttgtttccgc cacatatata caaccgtaat ctctcactga 3268501 agcttccgct atttctcttc gcggcaaggt ttccagctgc ttattcacct cggctgaaac 3268561 cgtctcggcc agcgccatgg aatctgtgac aaacacacat gagctaagct tatcgtgttc 3268621 cgcctgtgac agcagatcgg ctgcaatttc gctcggaatc gctgtttcat cagccagcac 3268681 gacgatttca ctcggtccgg caatcatatc gatatcgaca tcgccgaaca cttctcgttt 3268741 ggcaagcgcg acataaatgt tgcccggacc cgtgatttta tccaccggct caatggtttc 3268801 tgttccgtat gctaacgccg caatcgcctg agcgccgccc attttgtaaa tgtcttttat 3268861 gcccagctcg gctgcagcaa ccaaaactcc aggagacagc agaccgtctt ttcccggagg 3268921 cgtgacgaga acgattcttt caacgcccgc tacgagcgcc ggaatcacat tcatcaaaac 3268981 agatgaagga tatgcggccg ttccccccgg cacatataca ccggcggaat ccagcgccgt 3269041 cactttctgc cccagcattg tgccgtcctt tctgtgataa aaccaggagg attgcagctg 3269101 tctttcgtga tattccctaa tattttcgat tgcctgccta atcacctgaa gaagacgtga 3269161 atccagtgag gtgtatgcct cctcaaattc ttcttttgtg accagcgggc tgtctatttc 3269221 gatgcagtca aatttcgccg tgtagctgcg aaccgcctga tcaccgtttg ctttaacatc 3269281 ttcaataatg gaccggaccg tctttctttg ctcttccgtt ccggcatcga tggaacgctt 3269341 gagagaaagc cgttccgctc cgctgatggt tttgatcttc attttgccgt ctctccttcc 3269401 acaacgagag ataggcggga tgccatttcg tcaatcacat cgtctttcat gcgatagctt 3269461 accgggttga caataaagcg agaggtaatg tcacaaatgt gctccgtttc aacaagccca 3269521 ttttctttca gcgtctgtcc tgtggaaaca atgtccacta tccgatctgc aagcccaatg 3269581 agcggagcca gttcaattga accgttgagc ttaataatct cgacttgttc tccctgctct 3269641 ctgaaataac tggaagccac attcggatac tttgtcgcga ttcttggcgc tactccgctc 3269701 cagtctgtat tcggaagtcc ggcgacagct aagtggcatt tgctgatgtt taaatccagt 3269761 acctcataca catcgcgttc ctcctccagc atgacatcct tgcccgcaat tccgacgtct 3269821 gccacgccat gctccacata cgtggttacg tccatcggct tcgctaatat aaaccgaaga 3269881 ttttcctccg gcacatcgat gatcagtttt ctcgaatctt caaactcctc agggagcctg 3269941 tagcctgcct gcctcagcag ccctgccgct tcttcaaata tccggccctt tggcatcgcc 3270001 attgtgagta acttacccat tttgctcttc ctttctggca ccgataaaat aagtgacgtt 3270061 tgcaaaagat tttgtcatct ggtcgatatt ttctattccc gataaatctt gaagaaccac 3270121 tttgttccct ttcatgcgtt cttcattcgc ataagcgatg gcttgcgccc gctgctcttt 3270181 gctgaaaata acagcgtcta tttcacaagg ttcgtccttc atatgaaggg cttcaatcag 3270241 ccggtcgatc cgaagcccga agcctgttgc cggtgcaggt gaatcaaaat ggcccagcag 3270301 cttgttgtaa cggccgccgc ttccaatgac aaaaccgaca ttctcggcgt acacttcaaa 3270361 taaaatccct gtgtaatagc tcatgtggct gaccatattc agatccaggc ggacattttc 3270421 cgtacatccg taatcctcaa gaatgtccca cagcgccttc agctcatcaa ccacgctttt 3270481 tccttgcgca gaatcgacga tttcctcggc acgtccgcat acttctatac cgccccgcag 3270541 ttcaaggagc tcaagcagcc tgcttttatc aatggaggaa agcgggagag acttgacatg 3270601 ctctctgtag ccgacgtagt tcttttcata taagaacctc cgcagcacat cagctcgttc 3270661 aacgtttccg agcacctcaa caaacaaagc atccgcaatg ccggcatggc caattgcaat 3270721 tttaaaggat gccagcccag cgttttttaa tgccccgacg actaaagcaa tgacctccgc 3270781 atccgcgctc gtcgtgccgt caccgattaa ctccactccg acctgctcga actcagccgg 3270841 acgtccgcct tcacgctcct gagccctgaa tacatttgcc gcatagccga ctcttagcgg 3270901 atgaccgtgt ttcagaagct tcgatgccgc cacccttgca atcggccccg tcatatccgg 3270961 gcgaagcacc aatgtcttgc cgtcctgatc aagtagctta aacagctgct gctcttcaat 3271021 tgctgactgg acgccaacgg tatcgtaaaa ctccagtgtc ggcgtttcca taaattgata 3271081 tccccattta tcaatcaaat cggttaacga tcgtctcacc ttttttttcg tttcgtataa 3271141 accgggcagt gtatctctca tgccgtgcgg tttttcaaac ataaacatca acccgagcac 3271201 ctccgctgtt atcttatgaa ggaaaattcc gaatccttta gttcgctaat atgataatat 3271261 gttagcagat gaaagaatga aaatcaacgc ttaacttcag taaggatatt tttagttcaa 3271321 atatccttct cctcattatg aaaaaatcat gaataatgta ttaaaggtac gtaatatctc 3271381 aaattcttta tgtttggcat gctataatac aaatcaaata gagaacaagg agataaagat 3271441 gaaaacactg cgaactctat gtgtcctgat gattctttca ggcgttattt ttttcggact 3271501 taaaatagat gcaaaagata tagatattcc ttttttgaac agccttaaaa aagtggtttc 3271561 tgatagcgat acagactcag ctgcgaatag caaaaaggag ctgaagggaa gcgcaaaacc 3271621 gctggatgtc atcctttaca atcaaatgga cgcaccccgg ctctataacg gctgtgaagt 3271681 aacaagcctt gcgatggtgc tgaattatgc gggatacgac gtgacaaaaa ataccctggc 3271741 aaatcaggtt gccacagtgc ctttgacata cagcagcgga ttaaagggtg atccgaatga 3271801 cggatttgtc ggggatatgg cgaatggccc tggtctcggt gtctaccatc gaccgatcta 3271861 tcagctggcg aaaacctatg cgggagacaa agtgtctgat ctgactggaa aaagtatttc 3271921 cgctgtttat cagcagcttg aaaaaggcaa tccagtttgg gttattacga cagccaactt 3271981 tacgccagtt gacaacatgc agacatggaa aacgccaaac ggaacgatag aaattacgta 3272041 cagcgaacac agcgtcgccg ttacgggata tgatgataaa tatgtgtatc tcaatgatcc 3272101 gtatggctat aaaaacagaa aaaccgatag aacaagcttt gaaaaagcgt ggaaacaaat 3272161 gggcagccag gccgtggtta ttcaaaagta aacacctgaa gcctcactat gctctattct 3272221 gagcaaatac gacaatattc atgctttttg tatcaatcgg taagatcgat tcattttcca 3272281 tttttcaccc aaaattgtct ttactttcag gctgtctgtt tttatgatta aagcagattc 3272341 agccttgccc cgatctatgc gagagaagcc ggtgcaagtc gctgacgctt ctcttgcaaa 3272401 aaatgaaaga tatccgggga ggatttatca ttgaaaaaaa tcgtgtctat cctatttatg 3272461 ttcggtttgg ttatgggttt cagccagttt cagccatcaa ccgtttttgc agctgacaaa 3272521 gtggtgcacg aaacaattat cgtaccaaaa aatacaacat atgacgggaa aggacagcgg 3272581 tttgtggcag ggaaagaatt aggtgacgga agccagtcag aaaaccaaga ccctgttttt 3272641 cgtgtggagg atggagcaac cctgaaaaat gtggtgcttg gtgcacctgc agctgatggc 3272701 gtgcacactt atggaaacgt taacattcag aatgtgaaat gggaagatgt tggtgaggat 3272761 gcgttaacgg tgaagaagga aggaaaagtg acgatcgacg gcggttctgc tcaaaaagcg 3272821 tcagataaga tattccaaat caataaagcc agtaccttca cagtgaaaaa tttcacggcg 3272881 gataatggcg ggaagttcat tagacagctt ggtggttcaa ccttccacgt tgatgtgatc 3272941 atcgacaagt gcaccatcac aaacatgaag gaagcgatat tccggacgga cagcaaaaca 3273001 agcacggtca gaatgacaaa tacacgctac tctaatgtcg gtcaaaaatg gattggtgtt 3273061 cagcatattt acgaaaacaa caacactcaa ttttaacaaa aaaagtccgc tgatgttatt 3273121 cagcggactt tttcaatctt tcttgcattt cttccttcgt atagatgatc ctcatcggat 3273181 ttccgccgac aaatgccccg tcaggcacat ccttatggac aagcgttccg gcggacacaa 3273241 ctgcgccatc tcctattttc accccgggca gaatggtcgt gttggcacca atcatcactt 3273301 cgtccccgat cagaactttg ccgatccggt attcgtgaat caaatactca tgggccagaa 3273361 tggtcgtatt gtacccgatg attgtatttg ttccgactga gatcttttcc ggaaacatga 3273421 tatctggcat caccatgagg gcaaaggatg tctgttttcc aaccttcatc cgcagaaatg 3273481 tgcggtacag ccagtttttc atccctataa acggcgtata tctcgcaatt tgaatgacaa 3273541 tgaaattttt gacgaccttt aaaaaaggta ccgtttgata gacatgccac agtgagttgg 3273601 cccccgagac cggatgacga tctgtttttc tcacagatta cttcactcca acgatttgta 3273661 atagatcact cattttctca agcataaaat ccggctcatg cttcgccagc atttccggcc 3273721 ctttaatcgt ccatgcgact cctgccgttt ttgtaccggc gtttttccct gccagcacat 3273781 catggtaatt atcaccgacc ataatggctt ccgccggctc gcttcctagc tgtttcagcg 3273841 ctaacagcac aggctcggga tcaggctttg cattcgtcac atcatcaagg gtgacaactg 3273901 tttcaaagaa ttcgccgatt cccgtgagct tgaggcccat attgacagta tctcttaatt 3273961 ttgttgtcac aattcctaat gtaaagccgg ctttttttaa tgcatccagg gtctcatata 3274021 ccgtttcata ttcagtgacg agtgaatcat gcatgtcatg attgtacgct ctgtacatag 3274081 cgatcatatc ctcgcattta tcagggtcca tcgaagagaa cgtatcaaaa agagacggcc 3274141 cgataaatgc aaggacatct tctcgtttat acttgctcgg ataataatgc tccagtgtat 3274201 gcaaaaagga cgcgataatt aattcattcg tattaataag cgttccgtct aaatcaaaca 3274261 gaatcgtcgt tacttgtttg tcactcatat tgcttccttt ccaaccgctg agggtttcca 3274321 ttttttccac gtgtgcgcaa tagccattgt cagcagaact gctgtggtga cacgaatcaa 3274381 aagaagcggc cagaccggta tgccaagcgg aataaagaca agtgtatctt ccacgaccgc 3274441 gtggcaggca acgagaaata taaatgccaa tgtcatgtcc cgcttgctca cgccgtcatc 3274501 ctcgacagct ttgatcatga cacccgctcc gtaggccaga ccaatcgtca gtcccgtcac 3274561 catcgtcata gacgtatttt tattcatgcc aagcagctgc gtaaacggcg acagccacct 3274621 ggaaaaccga taaagccagc ctaaatctct taaaaactgg atgataatca tcagcgggat 3274681 cactattgcc gccagctgca aaacaccaag tccggctttc gttaatgctt ctgccaacat 3274741 tcctagccag ctgtctggcg ccgcgctctt cgcagcgata aaaccgtact gcgccgtttc 3274801 ctttccgcca tgccaaatga ggttgatgac gatggctgac acagcggcca aaccgatgcg 3274861 cacggccaat atgacgccaa ttctgatacc aacctttgcg gcaactgtcg attcgataat 3274921 caagttatga cagaaagaaa gcataacagc taaaataaag acttctttca cagataaatc 3274981 caatgttaaa atcccggcaa ttcccgcata cagattcagc atatttccca gtacaagcgg 3275041 aatggccgct tcaccagaaa gcccgaagag acccattacc ggtgtgatca gccgtacaag 3275101 ccaatccatg acaggggtat gctggagcaa agtgaccaat agcgttaccg ggaaaatcac 3275161 tttacccagc gtccatgttg tttgaaaacc tgctgcaaga ccggccagaa agatcttctt 3275221 catccctcat ccccctttgt tgacgtctac tccgcgtacc gctccttcga gtatcccttg 3275281 acgcgtctga agatgatggc tgccacagcc aaaacaatca atacgattga aatcacctga 3275341 gcgatgcgaa gtgaatcagt cagcattaag ctgtcagtcc gcattccttc aataaagtat 3275401 cttccgattg aataccaaat gatatagatc aagaacatct cgcctctacg caaattcgct 3275461 ctgcgcagca gcagtaaaac aatgacgccg acaaagctcc atagtgattc atataaaaaa 3275521 gtaggatgat aatattgccc attgatatac atttgattga tgataaattc aggcaggtgc 3275581 aggttttcta aaaaggctct gctgacagcc tcgccgtgcg cttcctgatt catgaagttc 3275641 ccccagcggc cgatcgcctg gccgagcaaa atgctgggcg cggcaatatc cgcaagcttc 3275701 cagaacgaaa ggtttttcac tctcgaaaac acataacccg ttaaaatggc gccgattaat 3275761 ccgccatgaa tggcaatgcc gcccttccaa atcttaatga tttctcccgg atgtgccgca 3275821 taatagtccc attcaaaggc aacataataa attcgtgcgc aaataatcgc aattggaatg 3275881 gcaaacagga caagatcaat aaacgtatct ttctgcagcc cccgtttttc actttccctc 3275941 atcgctatcc acagcccgag caaagcgccg agaccgataa tgattccgta ccagtggacg 3276001 gctaacggcc ccagctgaaa tgctatcgga ttgagtggtt ctatcgcttc attcatttaa 3276061 cgccaactcc tattcttctt gttcaccgtc ttcaatgacg tccgccagct tgttggtaaa 3276121 ttgttcagcg gcattcagcc ccatccgctt caatctgaag ttcattgctg ccacttcgat 3276181 gatgactgca agatttcggc ctgggcggac gggaatcgtc agttttgtaa tttctgtatc 3276241 aatgattttc atggtctctt cctcaagtcc gagccggtcg tattgcttgc cctgctccca 3276301 gagttcaaga ttcatgacaa tcgtgattcg tttattgctt ctgaccgcgc cagcgccaaa 3276361 tagcgtcatc acattgataa tgccaaggcc cctgatctca agaaggtgct caattaattc 3276421 cggagcgttt cccacaagag tatcctgatc ctcctgccgt atttcaacgc aatcatcggc 3276481 aacaaggcga tgccctcttt tcacaagctc tagcgctgtt tcgctttttc cgacgccgct 3276541 ttttcctgtg atcagcacgc cgacaccata tatatcgaca agaacgccat gaattgctgt 3276601 ggtaggcgcc agcctgctct caaggaagtt ggttaaacgg cttgacagtc ttgtcgtttt 3276661 cagcggcgat ctgaggacag gcaccccatt tttctcggag gcgtcaatca gctcctgcgg 3276721 gatgggcata tctctagaaa gaataatagc tggtgttaca tcagtgcaca gagaatccat 3276781 tcgctgcttt ttctcctctt caggaagctg ttcaaagaaa gaaagctctg tttttccgag 3276841 aagctgcacg cgctccctcg ggtaatatgt aaaatatccg gcaatttcaa tacctggtct 3276901 tgataggtca ctcattgtaa tcgggcggtt aattccttct tctccgctga ttaattccaa 3276961 attgaactgt tccattacgt cttttgtgcg aacctttgcc acgatatgtt cctcctgttc 3277021 cgggctgccc cgagcttgct cacaatactt tcattttatc actttcgggc ttgaacctaa 3277081 aacagatttt ataaaagggg ggaaaacacc tcagctggtc tagatcacta gtctgaaaaa 3277141 gagtaaaata aaggtattca aattccagaa aggcggatca tctatggcag agagtcttct 3277201 tatcaaagac attgcgatcg tgacagaaaa tgaagtaatc aaaaacggct atgtcggaat 3277261 caatgacgga aaaatcagca cagtttcaac agaacggccc aaggagccat attcaaaaga 3277321 gattcaagca cctgcggatt ccgttttgct tcccggcatg attgacattc atatccacgg 3277381 cggctatggc gcagatacaa tggatgctag cttttccacg ctcgacatca tgtcgtcaag 3277441 actgcccgaa gaaggcacga cgagcttttt agccacaacg attacccaag agcatgggaa 3277501 catttctcaa gctttggtga acgcaagaga gtggaaagcg gctgaagagt cctctttatt 3277561 aggtgcagaa ctgctcggca ttcatttaga gggccccttt gtttcgccta aaagagccgg 3277621 agcgcagcca aaggagtgga ttaggccttc ggatgttgag cttttcaaaa agtggcagca 3277681 ggaggcgggc ggactgatca aaattgttac acttgcgccg gaggaggatc agcattttga 3277741 actgatccgc catttgaaag acgaatcgat tatcgcatcc atggggcaca cggatgccga 3277801 ttccgcattg ctgtcggatg ccgcaaaagc aggggcgagc catatgactc atctgtacaa 3277861 cgcgatgagc ccgtttcatc accgagagcc cggagtgatc ggaacggcgc tggcccatga 3277921 tgggtttgtg acagagctta tcgccgatgg cattcactcc catcctttag ctgcaaagct 3277981 tgcttttttg gcgaaaggca gcagcaagct cattttaatt accgattcca tgagggcaaa 3278041 aggactgaaa gacggcgtat atgagttcgg cggccaaagt gtgacggtaa gaggacgaac 3278101 agcacttctt tcagacggaa cccttgccgg ttcgatcctc aaaatgaacg aaggcgcacg 3278161 gcatatgcgt gagtttacaa attgctcttg gacggatata gctaatataa cttctgaaaa 3278221 cgcggccaaa cagctgggca tctttgaccg aaaaggcagt gtgactgtgg gaaaagatgc 3278281 agatttggtg attgtcagca gtgattgcga ggtgattctc accatttgcc gcggaaacat 3278341 tgcatttata tccaaggagg ctgaccagat atgaaagtaa tggaatgtca aacgtatgaa 3278401 gagctaagcc aaatagcagc cagaataacg gcagatacaa tcaaagaaaa acctgatgct 3278461 gttctcggtt tagcgacggg cggcacaccg gaaggcacgt atcgccagct gatccgcctg 3278521 caccaaactg agaatctctc atttcaaaac atcactacag ttaatttgga tgagtacgcc 3278581 ggactttcaa gcgatgaccc gaacagctat cacttctata tgaacgaccg tttttttcag 3278641 catatcgaca gcaagcctag ccggcatttt attccgaatg gaaatgcaga cgatttggag 3278701 gccgaatgca gacggtatga acagctagtc gattccctcg gcgacactga cattcagctt 3278761 ctcggcatcg gccgaaacgg acacatcggc tttaacgaac cgggaacgtc tttcaagtcg 3278821 cgaactcatg ttgtgacatt aaatgagcaa acccgccaag cgaatgccag atattttccc 3278881 tccatagaca gcgtgccgaa aaaagcactg acaatgggaa ttcaaacgat actctcaagc 3278941 aagcgcattc tgctgcttat ttctggaaaa agcaaagcgg aagctgttcg taagctgtta 3279001 gaaggaaaca taagcgaaga ttttcccgca tctgctttgc acctgcattc cgatgttacg 3279061 gttttgattg atcgtgaagc cgcgtcatta agaccttgaa aggaacatgc tgacttatga 3279121 atatcaataa acaatcgcct attccgattt actatcagat tatggagcaa ttaaaaaccc 3279181 aaattaagaa cggagagctg cagccggata tgcctcttcc ttctgagcgc gaatatgccg 3279241 aacaattcgg gatcagccgg atgacagttc gccaggcgct ttctaattta gttaatgaag 3279301 gcttgctcta tcgcctgaaa gggcggggca cctttgtcag caagccaaaa atggaacaag 3279361 cacttcaagg gctgacaagc tttaccgagg atatgaaaag ccgcgggatg acaccgggca 3279421 gcaggctcat tgattatcag cttattgatt caactgagga gctcgcggct atattaggct 3279481 gcgggcaccc ctcctctatc cataaaatca ctcgggtgcg gctggcaaat gatattccga 3279541 tggcgattga gtcctcacat attccgtttg agcttgcggg tgaattgaac gaatcgcatt 3279601 ttcagtcgtc gatctatgat catattgaaa ggtacaacag cataccgatt tcccgtgcaa 3279661 aacaggagct tgagccaagc gctgccacca cggaagaagc gaatattctt ggtattcaaa 3279721 agggagcgcc tgtcctatta attaaacgaa caacatatct gcagaacgga actgcttttg 3279781 agcatgcaaa atccgtatac agaggcgacc gttatacatt tgtccactat atggatcgtc 3279841 tttcataaaa aaagcctcca acccttttta aggattggag acatggcgaa aatcaaactg 3279901 gtctggtgcc ggacgatatg tttctttttt cgtcttgaac ttccagatcg gtgatttcgt 3279961 tttgccgtta aaactgtctt ccactataat gtaccaataa taaacagact gcggttcaag 3280021 atgatcccag cggaattcag ctgtgtcccc gctcttcact tgctcccgtt ttccgagctc 3280081 ttcattggta tatacgttac attcaaaata atcggtttcc acctttttga ttcttggctt 3280141 caaatcaagc gaaagggaaa attcatcctt gttgccatag gtatccgtat catagtagtt 3280201 cttatccttt acatacggag agtacgtcga tacgtgcacc atgtcattgg cttggtcaaa 3280261 ttgaagcaaa cgcaaatacc cttggccgcc ttctggcccg ccctgataat cggccagcat 3280321 ttgatgcaca agacgatccg gtttcccatc accatcatca tccagctcat ctgtttttct 3280381 catcgcacta tgataatgcc cgctcaacac catcacgaca ttcgggttcg gctttacgat 3280441 ttctttgaat attttctctc cgattgggct tctgtttccg ctgaccagca aatactcatg 3280501 aaaagctaaa atggccatcc ggtcaggatg cttcttcagc acctgattca tccacgcgat 3280561 gtcttcatcc gtaatgcccc atcccatgta cagcatgata taatcattgc cgttgctaga 3280621 aatcaggtca taatgtccgc ggttattttt ataggaaccg ccataatgaa attttttatc 3280681 aaaacgatcg ctgccaaaat atttgccaaa cgccctgtag gagccgtcct tatgtccgac 3280741 atcgtgattg ccggccagca cgccgtaagg aattccgctc ttatccagaa cggacattga 3280801 ccgatcagcg tttttccact gtctgatatc ggcggaatca tctacaatat cacccgtgtg 3280861 gaacacatat ttgatattga gctgcttttg attatctttt atccattcgg tctgtttatc 3280921 aaaaatatgc ggatagcttt cggcgtaata ctgtgtatca gacatccaga caaatgtgta 3280981 catatccttc gcaggaggaa tttcatcctg tacaatcaca ttcattttcg actcccgtac 3281041 aaaatcggcg gcaatcacag acgctttcag cgtaaacggt ttgtcatcct tcgcgacgaa 3281101 gctgtcaaca ggctgccatt cgtttgtccg ataattccaa gcatacatcg tcacctttct 3281161 ccccggcaaa gaactgccct tccagactga ttctgccaga tcattctcat caattgatgg 3281221 atcaaccgtc acttcaaagc gatgataagg gaaaagctct ttgttttctg tcgatactgt 3281281 ttttccatca gcagctgata cccgctccaa ttctttattc gtaaatgggg tctccctttc 3281341 cggcacaaag cttttcggcg gttcagtcag tgacgcgtgc ttaaatattt tcacatgatt 3281401 gcgcgctgta tattgaaatc ccctataaaa accaacatcc atggcatcat tcgtcggatc 3281461 tttcacccgt acagaaagct tggccttatg cgtgtcggct tcgctgtcta taacctccgg 3281521 ctggtccgga tgctctcgtt cggttttaaa tatcctctca atcactgttt tattgcccgc 3281581 gagatccgtt gctgtcactt ttagagaatg ttttcccggc aaaaggtcag aagatgacgt 3281641 atgatatggg agtgtaatgc tttctccatc taacgacgcc tccgcttcct caattctgct 3281701 ccatttatca tacatatccg cctgcaggat aaggtttcct ttatacgttt gcccctcggt 3281761 gatattcggc tcaatgtgag gtcctgaatt atctacccgt acaaccaggc tgacattttc 3281821 cttcccgtcg cttgcttgaa tatggtgagc gccttcagaa agctttgatg tatcccactc 3281881 cagcagctgt gatgtaaata gtccgtcagg cagattgaac tgaaattgcc agcttttatt 3281941 cgagcgctga ttatcgccaa taaagagttc cttctcagga gacaccctct gatctctgat 3282001 caccgttcca tccgataaca ccaatcgggc gtttttgact aagaagtcat cacggttttc 3282061 agccgtatca aacggagaca ccttcgaacc tgaacgtatc gtaatacgct gcagctgctt 3282121 ccctttccga agcagtgtct ctggcaatgg aacagaatag gtgcggtatt tatttgttgt 3282181 atcatcgaac accttcagca ctttgccttc catcgttacc gcgtttttaa aataaaggtt 3282241 cgttttcctc gtatcgaatg caaaatatac ttctttttcc atcgcgggct ctgtcacttg 3282301 ttttttcccg tcaatccata gcttaatgct gtcagctcgc ccttctgtcg tggctttgag 3282361 aaattgagtt cccgacagcg tgtctctgtt ttcaatattc atccgcagac cgtgcgcctt 3282421 gcttgtttgt ttaatatcaa tcattttgac cggcgttctc gcttcattga tcccgtcccc 3282481 ggccgccaca taatactcta gctgatcctt cccgatcaat tcaggcgaat acacaatata 3282541 atggaagaga ttatcgttgc ggtctttttc agcaagaatt cgcttaaacg gtttgttctc 3282601 atccgtccgg tagtaaaagg ccactgtttt cactaggctt cggtcccgta tgtcagcccg 3282661 cagctcaatg ctttcagcag ggcggacagg cttgcggtca gtcaaatcct caatgaccgg 3282721 cttttcttta tcgagcttga ttttccgttt ctggtcgggc acctgtgcct gtaatacggt 3282781 tccgggagac ggattctttt ccccgattga aatgttcaga agttctgctg ttccgttcag 3282841 tggatactta taaagcactg atgacagccg gcgcagcgca tgtttccgat aatgcgcaac 3282901 cgaaatgtcc tttcctgtat tcgttgatat cacaacggcc cgcggcctcg tattggccat 3282961 accctctgtc tcgtctatca ccgcaagatt ttttccttct tttagttgtg tctgataata 3283021 acgattgaaa tccgctgacg tcaattctgg atgcccggca ggcttcagcc agacgacaaa 3283081 cgtttcgccg gatggtatca agatcctttc atcaggtctc caaatcagat cggagtcagg 3283141 cccttctttt gggtagcggt aacggatatg gtagtcttta aaatcaatcg ttctgtcagt 3283201 cgtattaaaa atctcaataa attcataacc gtctgcgcgt cctatattct tcgtatcaac 3283261 cgccagctct gtgatcagaa gctccggaat atgggcaagg tcagcctggt atccttcaag 3283321 cttcagtttc ttcgtctccg actcaacccg ctgcttccca ttcgacatca caatgtaata 3283381 ctcaagctcg ctgttccaaa tcaaacgttt cggaatttgt gccaaaaact tgcggaccgc 3283441 tccgggggtc gggtccatcg gcaccatttt gtagcccagc tcattacttt gtttataaaa 3283501 aagaaaggcg gaaaatgctt gatacgaatt atcgcgaact tgagcctcaa tcattagatt 3283561 gcttctcatt tcagctttca catcaatttg aggaggattt tcaagcaagg gtatgtaatg 3283621 aggcgtttga aatagttcct gctgtacaac aggaaaagct ttcgattcat gatggccgcc 3283681 agacaaaacg gaaagaaaag acagtaatat agaagcaata accgtgtatt tcctcatcaa 3283741 agcacctccc ttttcatgta ttttgcgtct gaacagggaa gcttatgagt tcatttttgt 3283801 gcataaagaa caaaaaaacg tctgtctctt gaaaattcca ctattaccca gtaaactaag 3283861 gatagttaac cagttaacaa ttaaatcaga gaggcaaatt gatggacaac agcattcatg 3283921 atgaattatt tcaagctata caacaattcg cattaaaaag ggataaacgc gtctggcaaa 3283981 aggtgcagat accatccatt ggcatatcct cacaacatca cgatcacctc aaaaaagact 3284041 ggactttgac ccagcttcac attgtttcct gcatacatac cagccaaaat gtgaacaaca 3284101 gcttcttagc atcccgttta cacatctcaa aagccgctgt ttcaaaagcg gttcatgctt 3284161 tgttgaaaca caatatcatt acagtgacaa aaaagcctgg caacaaaaaa gaaatttttt 3284221 atacgctaac tgatagcggc agaaaattgg cggcattaca tgaacagctt catgagaaag 3284281 caaaggagca atataaacag cttttcaatg aattttcaat tgatgattta aaaacagtga 3284341 ctgcgttttt caacttgtgg atcaaatata tgtaaaaaga gtctcacccg catgggagag 3284401 acctttggaa ttctattatg ccccgtcaaa cgcaacgaga agtgaaacag gtccgcgtgt 3284461 atacagaccg gactcagcat aacaaaaatc ttcctctaat ctgatattcc gcatcttatc 3284521 cagcacaata ttagctacaa tttcgatttc gtttttggca aaagctgctc ctacacagtt 3284581 atgaatgccg gatccgaaag cgagatgccg ggcggcgccg ctaaaagcgc tcttgatacc 3284641 aagatcttcc cgatgaatat taaacacgtc aggctgttca aatgcttcag ggtcccggtt 3284701 agccgcaccg atcatacaaa aaacaatcgt atcttttttg atttccatac cgccgaccac 3284761 tgtatcttgg gacagctgcc gcggaatcag ctgaaccggc ggtttataac gcaatgtctc 3284821 cgcaatggct ctcggaacta acgaacggtc agccaaaaca tcattcatct gctcaggatt 3284881 gttgagcaaa tggtagatca tcagtgccag cgtcttatca gccggttccg ttgcggctaa 3284941 cagcacatta agaatcagtg cgagtatatc cttgtccgac agcgccatgc cttcatattc 3285001 agaagtacat aggatcgaaa ttaaatctga tcccggattg acgcgacgtt ctttaatgac 3285061 cggcatcaag tattgggaaa gctgttcgct gcaccataac gaatgtgccc gcgcttcagg 3285121 agattgagag atactcgtga taaaatcggc aactccgctg tgccactcag agattttttc 3285181 atggtctctt ttatccagcc cgagcatgtc catcgtgacg cacaccgcaa acgtctttcc 3285241 aaaatcattg acgagatcac ttttccctct ttcaagataa ggcgctaaca agttttctgc 3285301 attttgttta atcaatggag acagatgatc cagtgcgtca ccgataaagc ttctcactac 3285361 aattcttctt ttggcagagt gttcttttcc atgcatttgg gccagcacag ggcctcgcat 3285421 gactggttcg gcacgctcaa caagtgattt cgtcgtgaag atatccggat gctgaaggat 3285481 atagcggaca tcatgatagc ggctgataaa ataactgtct atcgactctt cataatgaac 3285541 cggatcttcc tcccgcagtt gtgaaaaata agcatatgga ttgttttgaa attgatcaga 3285601 aagcacacta aacaatttaa tcgattggct catgttttac tccccctatc atccttcaga 3285661 tgtgatccgt ttctcagaaa gcatctgcgc catttcctgt acaatgagat acccttgatt 3285721 cggccgcata caaatagaaa attcatggtt actgatcttc tcacccagct tccacggacg 3285781 atgataagca aggagtgtct cttccacctc taaaatatcc ggagctccga taaaaaacgg 3285841 cagctcagct atgacatatt ccacagccaa attcagcata tcctcactga cttcttccat 3285901 catcaaactg acgccccgcg cacgcccgat tatcgcttca cgagacatgt ccaaacaagc 3285961 atgtcgaaaa tgaggctgct caaaaaatgc atgttcaact tcttgtctca acagctggta 3286021 ggctttgtta tctataaaat cagaaaatgt atgaatcgcc ttcggatccc cgccatgagc 3286081 cacaagggct ctttctgcaa atctcctgtt tcgtgatacc tctttcctta cttttcgttc 3286141 agcctttcct ctcggagttc caagcgcttc tagaagatta gccgcctcat gccctgcaag 3286201 taaaactgaa acgcttttaa attgagcttt cgcccatcca attaatctgt aaatataatc 3286261 ctctgaaaac ctgctgttaa atgggctgat ccccaccaaa acatgcctgc gccgttcaaa 3286321 tatttctctg cagttttctg ttaatgcctc agcaataaaa tgcacagacc ttctttccgt 3286381 taccattccg gtcatctcat tcacccctaa aacttatccc gctttaagtc atcaccctca 3286441 aatacaagat ggaatagcta gaacaactga acaagacgaa tggcaggcat cacttaaagt 3286501 ttccaaatgt tttttaagat tttaataatc attttcaata cccatatcat gataaatgtt 3286561 tactagtaaa cattagtcat tttatccctt ttccttccaa acgtcaatat gatctgtgcc 3286621 caaatatttg aaaataaatg taaacatcac attttccaca cactttttac acgcatattc 3286681 agcatgacat atcaacaaat agtctaaaca ccaacaattg acaacgaaaa caagaaaaga 3286741 taaaataaaa ttgttcacca gtaaacgatt tgttttattg tttcatcgta aactattatt 3286801 cctaagaaag aaggtagcct atgtctgatt tgacaaaaca gatgatatac gacatatacg 3286861 tgagactgct gcaccttaat gaacaaaaag cgaacacttc acttcagcaa ttttttaagg 3286921 aggccgcaga agaggatgta gctgaaattc ccaaaaatat gacaagcatt cacgtcattg 3286981 actgcatcgg ccagcatgaa cccattaata atgccggaat tgccagaaaa atgaacttat 3287041 cgaaagcgaa tgtaacgaaa atcagcacaa aactgatcaa ggaagaattc attaacagct 3287101 atcagctgac agataacaaa aaagaagttt attttaaatt aacccgtaaa ggcagacgga 3287161 ttttcgactt acatgagaaa ctgcataaaa aaaaggagct ggctttttac caattcctcg 3287221 attcattttc acaagaagaa caaaaggctg tattgaagtt tctagagcag ttgacgtcaa 3287281 cacttgaagc agaacaaacc gatgggactc cagacaaacc tgtaaagtaa acaaaaaggc 3287341 ggtgtacact ttggctcata caaaatcaaa ggcagtattg atcttataca ctgtttgctt 3287401 cagtgcattt tttgcatctt taagccagaa catttattca cctattcttc cgatcattaa 3287461 agaatcattc catgtttcca cagctatggt gaacctgtca gtctcagttt ttatgattgt 3287521 gacagcaata atgcaaatta tattaggagc gatcattgat tttaaaggcg ctcggatcgt 3287581 cttgattacc ggtattctgg caacggcagc agccagcatc ggctgtgcgg tgactactga 3287641 ctttaccttg tttctgatat tcagaatgat acaggcagcc ggttccgcag cactgcctct 3287701 tattgctgcc acaacgatcg gacagctgtt tacaggaaat gaacgcggga gtgcaatggg 3287761 aacgtatcaa atgctcctgt ctgtcgcacc ggctattgct ccagttctag gaggattcat 3287821 aggcggagca gccggatacg aagggatttt ttggatactt gcggccatct ctatcgtttt 3287881 gctggtgaca aacagcatca cctttcctaa agattctcca actgaatcta tgcagcaagc 3287941 caaaggcaat gtgttcgctc attataaatc aatatttaca aatcgaacag ggaacgtcat 3288001 tttgacttta agttttgttc tctttttcat ttattttgca gtaattgtct acctcccaat 3288061 attgctgaca gagcattacc atatagatgt gggtatagca ggactgttat atttgccgct 3288121 ggcgctgagc acgattgcag gtacgtttct gtttaaaaga atacaggcaa aaatcgggct 3288181 gcacaccttg tttatcggaa gcaatgtgat tgccgcctgc agcatcattt tatttgctgt 3288241 tacacattcc gtttctctcg ttctcatggc tctgacgctg gcactgtttg gcatctcgat 3288301 gggggttatt cctcccttgt actctacaat gattactaat gaatttgagc acaacagagg 3288361 gagtgcaatc ggaatgttta actttatccg atatacaggc atggcagcag gtccgatggt 3288421 atctgcctac ttgctcacaa tgatgccgtc tgccatgtcc tttagcctcc taggccttgg 3288481 atttgccgca ttgagctttt gccttcttcc gccaatgttt tcgccgcaga agcgcacgaa 3288541 acaaaaaaag caccacatgt aaaaaagctg cctttgcggg cagctttttt tatttttttc 3288601 taagcggctc taaaatgcct ttttgaatca gcaaatggaa gaccgacagg ataacggatg 3288661 cccatatcgc tgtgccgaag ccgtcgattt gaaagctgtc acccataatg gacgcggtca 3288721 tcataagcgt gatggcgtta atcacaaaca agaagagtcc aagcgtcacc atggtgaccg 3288781 gcagtgtaaa tataattaaa agcggtttaa tcagcacgtt taagatcgat aaaatgaggc 3288841 tggcgataat cgctgcccca atgctgctga tatggatgga gtcaatatat ccatcaatga 3288901 cgattaataa caatgcattg actaaaatgc tgactgccca ttttaccatg tcatttcata 3288961 tccctttctg acgggacgat aaaaatccaa atgatataaa tgagcaaaac cggcaagaca 3289021 cttgtcataa tggctaagat gacagttatg actctgagga gtgatgcgtc ccaattgaaa 3289081 tattccgcga gacctccgat aacaccggcg attttcttat ttttttctga gcgataaagc 3289141 ttattcattc gatcacctct gtgagtactt tagtttgatg gcgcctgtta gtgattctga 3289201 gaagacggtg atgttttgat catgtgcctg atttgaagtg aacatcattt ctttttgaat 3289261 cgtatcattt ttttccttca gcatctctac atccattaat tcatgggaca gcgtaccaag 3289321 attgcttttc agctctgcct tcactgcgag atcgtccgga attgcaagct ctacatttcc 3289381 agtcgttgtt tttgcataaa tggagcggca gtctgattct gttacgttaa tcgcaatatt 3289441 tccgttaaag ctttgaacgt caatggattc gcttttccct cggagatcga tcaatccgtt 3289501 aatggtttcc gcttctatcg taccgcagct gtggcttgcg agcttaattt gcccgttggc 3289561 cgtttcagct atggcttttt cggctgttaa atacgagaac gacagcacgc cgtttgtcgt 3289621 tttcgctgag aactctttta catgtaaatg ttcccctctg actggaccgt taaacagctt 3289681 cacccgaatc ttatcatact ccttctgagg aatatacaaa gtgacattcg ttttcatcgt 3289741 ctttttctca gtacggataa aaaacttatt acctttgatt tcacattcaa tatgctgaag 3289801 aaatgcgtgt ctcgccgcat cctggctgtc agcgcgatat accttcgcct ggcattccgc 3289861 tctgatatcg tcatcttccc aagggacgat atttacgctg ccattggcaa tttgcagctc 3289921 aacactggaa aagtcagtat ctttaaattg aaaaatgtgc tgaacatcat acgcatggcc 3289981 aaagtttaaa tcaaggtcaa cttccttgac ctttttcaca gcagaatcaa tccagtcaaa 3290041 cagcttggct cctaaagacg gtttgccgct ttcttttttt gccgttgtaa atggctcttc 3290101 ctcgtcatga acgtgaactg agagcgctgt gattttctct tctttttcct tgtagtcgct 3290161 gtcaagcttt tcaatcagtg tcaaagcttc ttgtgctgta agctttcctt cctcaacaag 3290221 cttaaggatt cgttcctttt cttgcttcat tacgatctcc tccccattgt ctacttatgc 3290281 tgcacgcagg accttaatgc cctgaatcac attccaaatg ataatgccaa tgacaactaa 3290341 gaaataaata accgctcccc cgatgattac aaatacagga agcaagctgt ctccatcaat 3290401 cgcaacggct ccgccaagta aagcaataaa aaggaacagc cagccgacaa acggaacaat 3290461 gtgagaaata agagagcgta tcgcatggcg ttttgtttct ttctcattta caacaaaata 3290521 tgcgacaatc ggcacaatga ttggcgcaat gaacacactg aaataacaaa gtgatgcaat 3290581 aatagcttga ttacggttca attcattcca cactcctatt gtgaattgtc catgacaaaa 3290641 gatcagggac gttttactta tttatacgtt taaaatctct tcaggtttca aattcattct 3290701 ttagacatgc tccgatttac ggaaattgga ttttaaaaag ttttagaagt agaatcttcc 3290761 ggctataccg attacaatat gtaaaaagct tacggcaacc aaggaggctg gacaagcaat 3290821 ggagaaagat cccagtgact atacagtaac acaagaatca gtgttaaagc tgattcagga 3290881 acaaaaaaga atgaatcgtg aaatgatcac cgagcttgag cagattcacg gacccttccc 3290941 gatctctcac gatatccaat atataaaagt gctgctcgac agcagcaaca cacatattgt 3291001 tcaagattta atgagtgtaa gtaagcagct gtataagaag actttgtaat tgcggaaaac 3291061 atatcattca ttataactga aacaaagcta aaggttagat gacaatatct tgcctttttt 3291121 gttttgaaaa aacaagtgat tccctggctg tcacaaaatg attgtaacaa aaaaagcctg 3291181 ccggcacatc cagttaatgg actctgtcgg caagctgtaa ctatcagaaa gagatagccg 3291241 ttcaaaatta acgtaacaat tgaagcacgt tttgcggctg ttggtttgct tgagcaagca 3291301 tcgcttgaga agcttgagaa ggaatgttgt tctttgtgaa ctcgctcatt tctttcgcca 3291361 tgtcaacgtc acggatacgg gactcagcag ctgtcaggtt ttcagaagaa gcaccaaggt 3291421 tgttgattgt gtgctctaga cggttttgta ccgcaccaag tttagcacgt tggtttgaga 3291481 cattgttgat tgcagtatca atactttcaa gttgtgtatc aaaaggagta ttagcaaaat 3291541 ctgttacatt aagtgcgttt actcctaaag cagttgatga catgctgtca atgttaactg 3291601 taagctgctg gccagcattt gctccaattt ggaaagtgaa accatcagtt tcagtaccat 3291661 ctaataactt tttgccgttg aattcagtac gatttgaaat gccatcaact tcctcaataa 3291721 gcgcatccat ttcatcttta attgcaccaa gatcttctgc ttgttgtgta cctgtgtttc 3291781 ctgcttgaac agtaagttca cttctaaacc tattatgccg taaagaaaaa gcttgcctgc 3291841 taagcccaag gatggacttg ccgacaagct gtcccctctt aacagagggt tttaagatgt 3291901 agctgtttct tttgctttca agagcgattt catgcgtgtt ttgtcacgtt cgataacagg 3291961 ctttaaataa cggcctgtat acgattcttc aacttcagtg atttcctcag gcgttccaga 3292021 cgcgacaatg gttccgcctc cggctccgcc ttccgggccc aaatccacaa tgtaatcggc 3292081 cgtcttaatg atatcaagat tgtgctcaat aaccagtaca gtgtctccgt tgtctaccaa 3292141 ccgttgcagc acgacaagaa gcctggcgat atcgtcgaca tgcaaacctg tcgtcggctc 3292201 atctaaaatg tagagcgtac gtccggttga gcgtttgtgc agctctgacg cgagcttcac 3292261 gcgctgcgct tctccgcctg acaaggtcgt cgccggctgg ccgagcgtaa tataacctaa 3292321 accaacatca taaagggttt ggagcttgcg tttgattttc gggatatttt caaagaaaga 3292381 aagagcatct tcaaccgtca tatcaagcac atcagagatg ctttttcctt tgtacgtcac 3292441 ttcaagcgtt tcacggttat agcgtttgcc gtgacacacc tcgcatggaa cgtatacgtc 3292501 aggaaggaag tgcatttcaa ttttaataat cccgtctccg cggcaggctt cacatcgtcc 3292561 gcccttcacg ttgaagctga aacggccttt tttatagccg cggaccttcg cttcatttgt 3292621 ctgcgcgaat acatcacgaa tgtcatcaaa tacaccggtg tatgtcgcag ggttggatct 3292681 cggcgttctt ccgattggcg cctggtcaat gtcaatgact ttatctaaat gatccaaacc 3292741 tttaatctct ttatggctgc cgggcttcgc tttcgcttta tgaagctttt gcgccagcgc 3292801 cttatgcaaa atttcattaa cgagtgtact ctttcctgaa ccggaaacac ctgtaactgc 3292861 tgtaaacgtc ccaagcggga acttggcatt cacttttttc aggttgtttt ctgatgcacc 3292921 tttaatttca atgtaacgtc cgtccggctt tcttctttca ggaggcaatg ggataaactt 3292981 tttccctgat aaatagctgc ccgttaatga atttggatct tccatcactt cttccggcgt 3293041 acccgcagat atcacctgtc cgccgtgaat gccggctccc ggtccaatat ctattaaata 3293101 atctgctgcc atcatcgtgt cctcatcatg ttcgacaaca atcagcgtgt tcccgaggtc 3293161 tctcatattt ttcagagcgc tgatcaagcg gtcgttatca cgctgatgca gaccgataga 3293221 cggctcatct aaaatataaa gcacaccgga taaacgcgag ccaatttgag tcgccagcct 3293281 gatgcgctgc gcctctcctc cggacaatgt acccgctgcc ctgctcaatg tcaggtaatc 3293341 gaggccgact ttgtccagaa agcttaagcg ctccacaatt tcgcgcaaaa tcaaattggc 3293401 gatctgcata tccttctcag aaagggtaag atctttaaag aaggcaagtg cgtcggcgac 3293461 agacagctcg gtaattttcc caatgtggcg gccgtcaatc agtacggcaa gcgcctcttt 3293521 ctttaaccga tagcctttgc acgtcggaca agacttctga gacatatact gctccatttg 3293581 ctcacgtatg aaatcggagc ctgtctcctt atagcgtctt tcaatgttgc gcaatacgcc 3293641 ttcaaattga atttcacctt cgcggatttg tccaaaatca ttttcatatc ggaaataaat 3293701 caggtcatcc ccgctgccgt acagcacttt atccagttga tgcttcggca aatctttgac 3293761 cggcacatcc atatcaatcc cgtagtgggt gcagactgcc tcaagcagct gaggataata 3293821 ttgtgagctg atcggtgtcc aaggggcgac cgcattctcc ttcaatgaca aatcttgatt 3293881 ggggatgaca agatcggcat ccacttcaag cttcattccg agaccgtcac acgtcggaca 3293941 cgccccgaac ggactgttaa acgaaaacag acgcggctca agctcaccaa ttgaaaatcc 3294001 gcagtgcgga caggcatgat gctcgctgaa catcagctct tcctcaccga tgacatcgat 3294061 cataacccgt ccttcaccta aacgaagcgc cgtttccaat gaatctgaca gccgggctgc 3294121 cacgccttct ttcacgacaa tccggtcaat gactacctca atggaatgct tcttgttctt 3294181 ttctaattcg atatcgtcgg aaagctcagc catctcgccg tcaattctga ctctgacata 3294241 gccttgtttc ctaatctgtt caagcacttt gacatgagcg ccttttcggc ccgagacaat 3294301 cggcgccagc acctgaagct tcgtccgttc cgggtattcc agaattctgt ccaccatttg 3294361 ctcgatggtc tgggatgtaa tctcaattcc gtgttccgga caatgaggct tccctactct 3294421 cgcatataaa agacgcagat aatcataaat ctcagttacc gtaccgacag tagacctcgg 3294481 attgcggctc gttgttttct gatcaatgct gatggcggga gagagcccct caattgcatc 3294541 cacatccggc ttatccattt gccctaaaaa ctggcgggca taggcagaca gcgactcgac 3294601 ataccgtctc tgtccttcag catatatcgt gtcaaaggca agggaggatt tacctgatcc 3294661 ggacaaaccc gtgacaacga caagctgatc tctcggaatc gttacatcta tatttttcag 3294721 gttatgcgcc ctggctccct tcacctctat ccgatccata gccatttgtt catcatcctt 3294781 ccgcttttag ctctaaaagt aaatcgcgaa gctccgcggc tctctcaaag tcaagcgcct 3294841 tggcggcttc cttcatttca tgctccatct gttcaacgac tttctggcgt tctttcttcg 3294901 tcattttcga cagcttcggc gcggcttttg ttttgtattc cgctttatcc tcagctgcta 3294961 ctgtggcacg aatgacatcg cgaatttctt tatttatcgt tttcggcgta atgccgtgct 3295021 cttcgttaaa ccgctcctgc tgctcgcggc ggcgttttgt ttcattaatc gcaatttcca 3295081 tagacttcgt tattttatcg gcgtacataa tgacgcggcc ttccgcattt ctcgctgccc 3295141 gtccgatggt ctggatcagc gaccgctccg aacgaaggaa accttcctta tccgcatcca 3295201 aaatcgcaac aagggatact tcgggaatgt ccaaaccttc cctcagcagg ttgatgccga 3295261 caagcacatc gtacttgcca aggcgcaggt cgcggataat ttcaatccgt tcaagcgtct 3295321 tgatctcaga atgcagatag tttactttaa tgccgatttc ctttaaataa tcggtcagat 3295381 cctctgacat cttcttcgtc aaagttgtca caagcacccg ttcattccgc tcgattcttg 3295441 cttgaatttc gccgatcaag tcgtcaatct gaccttcgat tggacggacg tcaataagcg 3295501 ggtcaagaag ccccgtcgga cgaatgatct gttcgaccat ttcatctgta tgttcaatct 3295561 cgtacggccc tggtgttgct gatacataca cgatattgtg catatgcttt tcaaattcct 3295621 caaaacgaag cggacggtta tcaagcgctg atggaagccg gaagccgtga tccacgagca 3295681 cctgtttccg cgcctggtct ccgttaaaca tgccgcgcac ctgaggaatt gtcacatgcg 3295741 actcatccac cacgatcata aaatcgtctg ggaaataatc aagaagcgta tacggcgttg 3295801 aacctggagg ccgcagagtc aaatgtcttg aatagttctc gatgccggag cagaaaccca 3295861 tttcacgcat catttcaaga tcatatcttg tccgctgctc taaacgctgc gcttcaagga 3295921 gctttccgtt ttcatgcatg accttcagct gctcctcaag ctccttctcg atattttgaa 3295981 tcgccttctc cattttctcg gcccgcgtta cgaagtggga tgccgggaaa atcgcaacat 3296041 gatctcggtc gccgagaatt tctcctgtca gcgcatctac ttcccgaatc cgttcgattt 3296101 cgtcaccgaa aaattcaact ctgacacaat gctcatcacg ggatgccgga aagatttcca 3296161 ctacatcccc gcgcacacga aatgtaccgc gctgaaagtc gatatcgttg cgggcatatt 3296221 ggatgtctac aagttttctg agcagctcgt tgcgctcaat ttccatttca gtccgcagtg 3296281 acacgaccat ttcccggtat tcctcaggcg aaccgaggcc gtatatacaa gacacactcg 3296341 caataataat gacatctctg cgctcaaaca aagctgatgt ggcggagtgt ctcagtttat 3296401 caatttcatc attaatacta gcgtctttct ctataaatgt atccgtttga ggcacatacg 3296461 cctccggctg ataataatca tagtagctga caaaatactc gacagcattg ttcggaaaaa 3296521 attccttgaa ctcactgtaa agctgtccag caagggtttt gttatgggca atcacgagag 3296581 tcggcttatt gacttcttta atcaaattgg acaccgtaaa tgttttccca gttcctgttg 3296641 cacccagcag agtctgatgc ttcttgccct cctgaattcc tttcacaagc ttttcaatgg 3296701 ctttcggctg atctccctgg ggctgatatt tcgagactaa ctcaaagcga tctttcacaa 3296761 aaataagcct ccgtttcttt aacgaaatct tcctatagat atagtaacac aatggaaagc 3296821 aaaatcacta aaaatacgaa ctaaagttcg gtggtttttt atttccagct gtttttgtgt 3296881 ataaaaaacc tgcttttaaa acgtaaaagc aggtattcag tctttatatt cattatgtcc 3296941 gatttattct tcttttttct ctgcagcttt tttggccata tacagtccgc cagccacaag 3297001 agacacaaca tccaatccta caataaaata cgtttctgta tagcctttta aataagaggc 3297061 aaacagcaat gcagctgtta aagcgatcgc cacataatga ttaaaggtga ctctagtaaa 3297121 tagaacaaca agcataaaag ggaaaaacaa tgcaaaaacg gcttttgtaa tcaacaaaaa 3297181 ccctcctcag ggattcttca tctgatctga ttatagtaaa aaatgaagaa tcggacaatc 3297241 gtgcattcgc tccctctact tacaccatac cccttttcag ccaaaatcaa tcaccatatt 3297301 tgcattttgg tgccggtcaa aacttattcc atggtgccgc tgttctaatc agcggcactt 3297361 tttttattac atcatcaagt ccgccgccag attccgagaa taaaagaaaa taggcataca 3297421 gtaccagtac ggccgcattt ttcaggataa tataaccaac ttaactattc attttattta 3297481 ggactttctg cgtttgacag cattttcctg aaaacctaca attaaatgat agtgtttact 3297541 atcatttttt aaacacaggc tccgcaataa aaagactaga gagaaaaaca aaatgaatga 3297601 agaaaagagg ggtttcaaat atgtattctg ttttatttcg ccaggcagaa gagtccagcc 3297661 agctggctgg agcaaaagga atgaatttga ttaaattgac caaacacggt cttcctgttc 3297721 cggacgggtt tattattcaa acgaatgcgc tcgcacgttt tatggaggac aaccagcttc 3297781 aagagactag tgaaaacgtc gaaggcggga tcatttccgg aacattttcg gatgagctga 3297841 aagatgagct gactagttcc ttttataagc ttagagaatc atatcgatcc gtagccgtgc 3297901 gttcttcgtc tgcttcggaa gatttagaag gcgcctcatt cgcgggtcaa tatgaaacct 3297961 acttaaatat caaaacagag gaagagtttc tggctaaagt gaaagaatgc tgggcctcat 3298021 ttttttctgg gcgggtcagc agctataaga aaaaaatgaa caatcaaatc gcagagccgt 3298081 taatgggaat agtcgttcag gggctgatcg attcagaaat gtcaggtgtt atcttcagcc 3298141 gcaaccctgt tacccatgat gatagagagc ttttaatcag cgccagctac gggttgggtg 3298201 aagctgttgt ttcaggaaat gttaccccag acacgttcat tgttaataaa tcttcgtttg 3298261 agattcagaa agaaataggt gcaaaggaaa tctacatgga gtctgcggca gaaggaattg 3298321 ctgaaaaaga aacgagtgaa gacatgcgca gccgtttttg ccttacagat gaacaagtga 3298381 ttgaattggc tgaaatcaca aaaaaaaccg aagacctgta cggatatcct gttgatatag 3298441 aatttggaat tgctgatcat caaatatacc ttctgcaagc tcgcccgatt acaaccattg 3298501 atcaggacaa aaaagcggca gaagaaaaac gcagcttcat gattaccgac actgatatga 3298561 atgatttctg gcttaacatg gagtctaata ttgaaggtcc ggtgagtccg ttattttcat 3298621 ccttcatcgt gccggcattg gaatatggct tgaagaagag catgcaaaag tttccgattg 3298681 gtgtagttgt tgatgaagta aaactttatc gcggacatat ttattccaaa aaccaaggcg 3298741 gacagcagcc tccttctgaa gactgcggca aagagctttt cccgatttta tcggagcata 3298801 tgtatgacat catcaatcac acatacctcc ctttttaccg gacactggac cagctcgcac 3298861 aaactgagca taccgcagaa agcgcactgg aagcttttca aaaactaaag gccttttatc 3298921 tcacggctta tgaagagcac tttaatatcg ttttcccgca aatcctttta acaaacaaac 3298981 tgcaagcgat gtatcaggac attcaaggag agtccgaaaa cgctcatttt tacgagatgc 3299041 tgacaggaaa aatgaacaaa tcactggaaa cggaccgttg cttatggcta ttttctgtgg 3299101 aagttcagga gaacccgaac cttctggcca tttttgaaaa caacaagcct gaacagctcc 3299161 aggagaaatt ggaacaaaca gatgagggaa gacacttcct gaagaacgtc catgaattct 3299221 tgcaagaata cggatggaga tctgttaaaa gtcatgatct gattgaacaa atctgggtgg 3299281 aaaatccgta tttcgctctg gccaatattc aaaattatgt ccgtaatggc tatcattttg 3299341 acaatgaatt tcagaaaaca aaagaaaaac gagagaaatt atacaatgaa ttcttggaaa 3299401 gcatagaaga tcccggttta cgcaccgaat ttgaccgcta ttatcaatgg acactgaact 3299461 ctgcaaatat aaaagatgat caccactttt atattgacgc catgctggat gccaaggcga 3299521 gaatctttct gctgaagata ggtgaattgc tggcggaaaa cggtgtcatt caagatcggg 3299581 aggacctttg gttcttatat gacgacgaag tggaacaagc gcttcttcac cctgtatccc 3299641 tgcaagaaaa ggctgaaaaa cgcagacaga tttttcatga gtatgagctg gcccaagccc 3299701 cggcctacct cggcaccccg acaaaagaac agctcaaagc agctgaagaa attgtcggcg 3299761 ctgtgataga ggatgaaaaa aacacagaga atcatatttt tggcattgcg gcatcaagcg 3299821 gcattgcgac aggtccggtg aaaatcattc gggacgccaa tgaattttct caattcgcgc 3299881 ctggagacgt actcgtttgc aagatgacca caccgctatg gaccagcctg tttcaagacg 3299941 ccaaagcgat tattacagac acaggcggca ttttgtctca cgctgcgatt attgcccgtg 3300001 aatacggcat tccagccgtt ctcggcacac gcacggcaac cgaaagactg cgagacggtg 3300061 acatcatcac tgttgacgga agcagcggca aaatcacagt tgtcagccgg tcctgatgcg 3300121 tccccctctt tcttatacaa gcggggcggg tgtatacttg tcctgccagt atattcgtga 3300181 ggtgaaacgt attgagaccg acaaacaaga gaatccttga tgctgccatg cagctgctcg 3300241 tcaaaaaagg atatcgcgca acgactacaa aagaaattgc agaaaaagca aatgtaagtg 3300301 aagcgacgat tttcaggaac tttaaaaaca aacaaggact agttgaggct ttgctttctc 3300361 agcattcttc aaacagaggc agcattttgg aacaaacaga aggggatttg tacaaagacc 3300421 tgcttcatat cggaacctgt ctcttggagg agctcgaaca tagaaaagat atcattaaaa 3300481 tcagctttcg tgaaccggcc atgtttcagg atgtcattaa ccacgtcact gaatatcccc 3300541 aatctatgaa acagctattg gttgattatc tcaaaacgat gggtgagaaa ggggttattc 3300601 agacaggaaa tgaagcggaa catgccgacg tgttcatgtc gattatcttc ggttatttca 3300661 ttcaccgtct ccacttagga gaccgggtca tatcaatgcc ccaggaaaaa atgctggagc 3300721 atagcacagc tctatttgtc aaaggaattt ctgctgatta actccttggc ataataaaaa 3300781 ggaggatccc aatgagctca agaaaagaat gggcgctgat cgtctcgcta ttattggggg 3300841 ccattctggt tcccattaac tcaacgatga tcgcggtcgc gctctcatct atttcccata 3300901 cgtataacga gtccatcgca agcatcactt gggtggttac cgtttattta atcgtgatgg 3300961 cagtcacaca gccgattgca ggaaagctcg gtgacatgta cggcaataaa acaatgtact 3301021 tatggggagt cggccttttt ctaatcgcat ctctaggctg cgccctttca ccgagtctgc 3301081 tcctgttaat tgtctttcgg gcattgcagg ctgtcggcgg ggcattgctt acgccaaaca 3301141 gcattgccat tatccggcat gttgtttctg aaaaacgcct accgaaagtg tttggatttt 3301201 tcggactggg cgcgggactt ggtgcagcac tcgggccttt tatcggctct atactgattg 3301261 acagcttcag ctggcattcg attttttggg tcaacatccc gttcctcgcc attgctttat 3301321 ttacggcatt aacgatgttt cctcaatata aagaaaataa atctgacgcg ccgctggata 3301381 tcatcggctc tctcttgctt gcaggcagca tcgtttccat tatcctgctg acgaaaaatg 3301441 aggctccatg gggatatact gtatacagtg tattgatact tctttttgtt ccgctttttt 3301501 tcagaagaga aaaacgtacc cagcacccca tcattgactt tgcactgttt aaaagctcaa 3301561 cctttacaaa tgcgaatcta tcagtcttgt taagcaattt gatgatgtat gccgtcttat 3301621 tgattatgcc gttatttatg acgaaccaat ttgggcttaa tacatctaac agcgggatgg 3301681 cgctttctgt attttcgatc ttcatgtcag ccagcaactg ggtgggcgcg cagctccatc 3301741 acaaatgggg agccaaaaaa atcatttttc tttcatttgc catgatggct ggtgcgaatc 3301801 tattattttt gctgttaagc agctcgcatt ctgtcttgtt cctcatgctc tctcttatcc 3301861 ttggcgggct cgcttccgga gtcggtctga ccagcatgca ggtttcatcc cttgccacag 3301921 tagaccccgg tatgtcagga gtggcatctg ggattttctc gaccttccgt tatttcggaa 3301981 gcatcatttc atcagcctta attggcctga tttcgggata tcacacccta tttatgattc 3302041 tctttgctgt atccatcatc ggcgtttttg tttcattggg catcaaatct gatgaaacgg 3302101 cacggataga aaaaaactca gcgtaacaca aaacagcccg gcatcgcatc atcctgcggt 3302161 gccgggctgc cttttatgat cccgaagcga ctgcttcgtc ttcacggtca tcctttacga 3302221 agaggatgcc caattcatga tgttctcctt cataagaagc tcgctggtca aaacgaattt 3302281 ctccattcaa accgataatt tcaagcttta catatgcacg gttatgctga agcgcttcat 3302341 agaaatcaga aacgttctta accggtatgc cattgacttt cgttatgatt tccccgattt 3302401 tcaattccag atcctcagcc ggcgtattgg ggataatccc aagcaccatt aagccctgat 3302461 cccttttcga gaaataaaac ggagccgcgt tatcattcac tctttgcttt atggacagaa 3302521 aaatacgccc taacaaagcg gtacagaccg ctgcacccgc aagcggcgtc cacagtaagc 3302581 tcgctgcacc gagaactgcg acggcaagac cgagaataca aacgcgtttc gctgtgatcc 3302641 ttatactcgt ttcaggcagc gatccctgta ccctttgtcc aaatccgaca aagtaaggaa 3302701 tccatagaaa atggaatgag ccgccgggaa ccgtaaacac gggccaccag ctaaggtgcg 3302761 attctaaacc attaccgggc acgagaagga acagcggcaa aagccaaacc cggtttgcca 3302821 gctgctgtcc gatcggcaaa ccgcggctgc ttacgacaag tgccggtgat gttctcacat 3302881 gcgcagaacg ataagcaacc gctccttcag tgataatcag caaacctaga aacacagcca 3302941 cagccggcca aacaactgca aatccttgcg gaaatctctc cagaaagggc tccgcctgat 3303001 atatttgcag tccaaaacct atcagcatac tcacactgac gatatatgca gcagacatcc 3303061 agtttgcgcg aagagtgaac gctgccgctg cagtgataac ggcaataatc gcaagtaaac 3303121 cgagaggaat cgatattccg agtccaccta aaataactga caaaagaaga cctggaatca 3303181 gtccctttgt atatgtaaat ttcagatcat cataaatatc tgctattctt gtatgaaagg 3303241 tttttcgttc ccgtttgatt cttacatagc cgaaagccaa ggttatgatg ataaaaaacc 3303301 agaaaagcgg gtgtaagaag aacaagcccg cgctttttaa cagttcaatt ccccattgaa 3303361 cagacactat ctctcaccgc ctcaagccaa acatgttact catattctat caaatattaa 3303421 atggcttgga tatcctcagg agagtttatc tctcttgcgt catccacagc gtgacattcg 3303481 atagtgaaaa atcctttaaa tagtggttta catccacatc caataacccg ctgattagat 3303541 gcatcgacct ttttatatct gtcagattaa ttcctaatcg cttatggttt ttcattaagt 3303601 agttaaaata atgtttggcg cattcctcat taatgtcatt tactgattcg acattggtgt 3303661 aattgaccaa atatctgctg aacagcataa gaagacttag tgcttttgta gctgaaaatg 3303721 ttacgtcttg tgttctgtct tttaattgtt ccactaattc ataatatttt tttttcacgc 3303781 acaatacttg ccctcttcaa ttgtgaaccc ccattttctt tatacagata agcacgggcc 3303841 agtataagca gcagtactgg agtgctaaca agcattctcg ctaacgttac tctttaaata 3303901 cctgtcgttc agctgccatt aacctgatta ctgttctttt tagaaccttc ttatattgta 3303961 tgaagtaaac aaagactagg caacttgcaa aagtttcatt ttaaatgcat attaactcgt 3304021 tagaaagtct ctctcatata ttgatatcgg gtaataacag tcctttataa atgtttattt 3304081 gtgaaaattt ttttaatttc ttgtcaaaaa ctcatttttt atgtgactta tgatccataa 3304141 tctctttaag cacaaagaaa caggagatga aataccatct cctttaattg acaaataatg 3304201 atttcaatgc tgtttgaagc tgcaaatcat ttttttcatc tgattttttc ttttctatct 3304261 gctgatttaa tgtctctgca gtgcgagtgt cgatcacacc ggttttattc agcttgtttt 3304321 gatcctgaaa agccataacc gcttttttca tgtctttgct gaaatagcca tcctcacgtc 3304381 ccggatcaaa gctgagacct tttaacaata cctgcgcatg cttgacgtct tcattgttca 3304441 tgtccacttt aagcggctct ttcagctgta agggcccggc ggaaaaataa tcgggctgct 3304501 taatcgcaat ggtcggttca attcctttct tatgaatcca gtttccattt ggcgtcagcc 3304561 acttgtaaag cgttaatttg atgttgctgc cgtcccccat tggcacagcc tgttgaaccg 3304621 ttccctttcc aaaagacgta tcgcctacaa catcataatg gccagcttcc tttaatgcgc 3304681 cggcaagaat ttctgatgca gaggcacttc ctttatccgt aatcacattg acagggtacg 3304741 cttttttatg ggtcaatgtt gaaaaataac gttttttatc tccattgcgt tcagcaatct 3304801 gaatatacgg ctgatccttt gtaacgaaat gcttaagaat ttcttccaca ctttgaagat 3304861 atccacccgg gttgccgcgt acatcaatga caagtccttc tatttctttt ttctcaagct 3304921 ccctcagcgc ttttgcaaaa tcctctgcgg tgtgctcaga aaaagtagag atggcaatat 3304981 atccgacaga atgcccctgt acttttttct ctgatgcaaa aaccgtttcg agcggaatct 3305041 cagctctctt gatccggaat gacaactgct tcttcgttcc aggccgctga atcttcattg 3305101 aaacgctgga cccttttttt cctcttattt ttaacacagc gtggtttaaa tccttgccgg 3305161 ccatcgattc tccattgatg ctgataattt catcattagg cttcaacccg gctttttccg 3305221 ctggcgattt cttgaatgga gaaacaataa taattttgcc gtcttccatt ccaacctcag 3305281 ccccgatgcc ttcaaatgag gaatcaagag aatcagaaaa ttgcttagct gtctgcttgt 3305341 ccatgtaaac agaataagga tcatttagcg tagacagcat tccctggatg gctccctcga 3305401 gcagcttttc tctatctact ttttctacgt actcattcga aattaactca tacgcttttt 3305461 cgattttgtc catagcttta tcccgttcag agtcagcttg tgccgtcgcg ggaactgctg 3305521 cagtctgggg cttatccatc tcaagcaggt tgattcccgc atatacaccg gcgcctccga 3305581 acagcatgct ccctgctgct atcacagcca ttattttttg attcatcctt tactcctcct 3305641 gtatgccaga ctgtctttac caaaacctag agatagtata tgtaaaggat ggagatttca 3305701 tgtaatcata gaagaaaaag aaggcaaatg aaaagccgtc ccgaaaacgg aacggctttt 3305761 tcactttata ctcgcagaaa cttgcggatg gaagtcagac ttccccatac tccaattact 3305821 gcgccgattg caatcagcac tagcgaaact tggaatacaa atggattata aggaagaaga 3305881 gagacaaatg atccttgaac ctttggaacg acccatccga tgacgtattg gtaagtgctc 3305941 agcaccagtg caatcggaat cacagaaccg aatacgccta gcagcaatcc ttcaaggaaa 3306001 aacggccagc ggataaacca gtttgtcgcg ccgacaagct tcatgatttc aatttctttt 3306061 cttcttgcga aaattgtaat tttaatggtg ttggaaatta agaacatcgc cgtaaatacc 3306121 aggccgataa ttaacgcgat tccgatgttg cgggaaacgc cgaccacttt aaacaaacgg 3306181 ctgacctctt cttttccata agtgacttta taaacatgat ccattttttc gatctttttc 3306241 gccacgttcg gcgtatcatg cggatctgtc gttttgacga caaacgcatc attaagcggg 3306301 ttttcctgat ccttcattgt cagggatttt ccgctgtcac caaaactgtc aaccagctgg 3306361 tcaagctctt tttctttaga tgaaaaagtg acactctgaa tgcccttcag ttccttaata 3306421 tcgttctgaa gcttgtcctg tgccttctga tctgcagtca gatcaatcag cactttgatt 3306481 tcgacttgtt tttctgcatt cgtggccatg ttattcaaat tcagcataat cactaaaaac 3306541 acgccgacta aaatcagcgt aacggttaca gcactaatgg atgcaaatgt catccatgtg 3306601 tttctcccga gagatttaaa actctcacgc aagtggcgcc cgagaatttt aatcatatga 3306661 accatactcc cctcttgact catcacgcac aatgatacca tcttcgattg caatgacacg 3306721 tttcttcatg gtgtttacga tttctttatt atgtgtcgcc atcacgactg ttgtcccgcg 3306781 gttgttaatt tcctccagcg tcttcatgac ttcccaggac gtatccggat caaggtttcc 3306841 tgtcggttca tcagcaatga caacatcagg gttgttcaca attgatctgg caatagatac 3306901 acgctgctgc tccccgcctg aaagctggtc aggaaattgt cgcgctttat gcttcagctg 3306961 cacgagatca agcacttcaa gcacccgttt cttaatgaca gacggctgtt ctccaatcac 3307021 ttcaagggca aatgccacat tttcaaaaac agtaagtttc ggaagaagct tgaaatcctg 3307081 aaagacaaca cctattttgc ggcgcacgaa aggaatctct ttttctttaa ttgtcgcgag 3307141 atctttatga ttgattaaaa tttgtccttt tgtcggtttt tcttctctgt aaatcatttt 3307201 aataaaagta gatttacctg ctccgctcgg accaacaaca tacacaaact cgccgggatg 3307261 aatggtaaca gaaatcccat tgagtgcttt tacgccgttc ggataggctt tatatacttc 3307321 cttcatctct atcatgaaat cacctaatct tttatatcat tttatctatc acacggtcat 3307381 actcttcgaa tgcattcgac aatttatgac ccattcattt gtaaaaagat gaaaaatctg 3307441 aaagttccct ttttcaatac acttcattat acgtcaaatt tagacataat actattacag 3307501 tttcttttca ttcatattgt caaggcataa aaacatcctt gccagcactc ggcaaggatg 3307561 tttttatctt actttttttc tgacagccat ttggcaataa cagcggcttc gttatcatct 3307621 acaagcccct ttggcatatt gccgcggccg tttttaataa tgctttcaat tttgtgttca 3307681 tcgtatttgc ctccgacctc ttggagatta ggccctgaca caccttctaa atccttgccg 3307741 tggcagccta cgcagctttg ctgatataat tcttcccctt cagatgcagt ggcttccgtc 3307801 ttgctgccag tgtctgtctt ctcttctttt gcatcgtttg atccgcaggc agccaacaga 3307861 acagaaagcg caaatccaat cattagtatc gataactttg atttcatgtt gagaagcaca 3307921 actcctttac gatctcttcc atattataac ctcgtttaag cgcgtttgaa accctcgccc 3307981 agcacctcgc tcgcgtctgc tacaattaca aaagctgact catcaatctg tttgacgatt 3308041 tgtttcaatt tggtgaattc agtttgccca accacgcaca ttaaaatcgg acggtcatcg 3308101 tcagtatatc cgccgactgc agaaattttt gtcacgcctc tgtcaatctt ctgtaagaca 3308161 gcctccttga cagcctgctc ctgctttgta atgatgagcg ccatttttga acgattaaag 3308221 ccgacttgca caacatcaat ggttttgctg gacacataga cgccaagcat ggcatataag 3308281 ccttgctcaa tattaaatac aatcatagcc gtaacaacga tcattccgtc aatgatggcg 3308341 agacacttcc ccaatgacag accggagtac ttatgaatga tctgtgcagc caaggctgta 3308401 cctcccgtcg aacctttccc taagtacaca ataccaattc cgatacctat cccgacaccg 3308461 ccaaaaatcg ccgccaggag ttcatgatga gtggcgggct gaatatccct tgtcagaaac 3308521 actactagcg gcaaaaacac agaacctgca agcgtcttta gtccaaattt cccgccgagc 3308581 aaaatgacgc cagcaataaa taaagggata ttaataatcc actgtacata cgctgcttca 3308641 aaaccatatg attgtaaaat cgtactgatc ccgctgaccc cgccggcggc aatcttattc 3308701 ggaagcaaaa atacattaaa ggacacggcc gtaatcgctg ctcctatcaa tatgtataca 3308761 taatcccgca aaatccacaa tgttttattc cgtacgtcca tcatatatcc tccgtttctt 3308821 ccaatgctct ccgatagcat tttaatcctt ccctgattag atgtaaataa cacccaaata 3308881 cagtggtaat atgctaaagc agcagtgaaa tcaaggatat aagaaataaa aaaacacacc 3308941 cgtatgcatc aggtgtgttt ttcagcttat gaaagcttag aacgcaggta ggcatcaata 3309001 aacgtatcaa tgtcaccatc cattacagct tgaacgttcc ccatttctgt attggtccga 3309061 tggtctttta ccatggaata cggatggaat acataagaac ggatttggct gccccagccg 3309121 atttcttttt gttcaccgcg aatttcatcc agctctgcct gctgctcttc aattctgcgc 3309181 tgatacagct tggccttcag cattttcatg gctctttcac ggtttttaat ttgtgagcgc 3309241 tccgtttggc atgtcacaac tacgttcgtc ggcaagtgag taatccgaac ggctgaatcc 3309301 gtcgtattga cgtgctgtcc gcccgcgccg cttgcacggt acgtgtcaac tttaatatcc 3309361 tccgtacgaa tatcaatatc aatttcatcg ttaaattcag gcatgacttc acatgaaacg 3309421 aaagatgtgt ggcggcggcc tgatgaatca aatggtgaga tccgcacaag acgatgaaca 3309481 cctttttctg ctttgagata cccgtaagcg ttgtgtcctt tgatgagcaa tgtcactgac 3309541 ttgattcccg cctcgtcacc tggaaggtaa tcgagagtct ctactttaaa gccgcggcgc 3309601 tctccccatc ttgtatacat tctaagaagc atagagcccc agtcctgtga ctctgtaccg 3309661 ccagcaccag ggtgcagttc taaaatcgcg ttatttttat catacggctc gctgagaaga 3309721 agctgaagct caaactcatt gaactctttt gttaatgact ttagttcttt ttcaagctca 3309781 agctggagat cagtgtccgg ctcttctttc aaaagatcat gagtcatttg taattcttcg 3309841 tgggattcat tcaatttttt atacgaattg acataatcct ttaaaccgtt tgcttcattt 3309901 ataaccgttt gagctttttg ctgatcattc cagaattccg gatcagccat ttgttcatct 3309961 agctcagcaa tgcgggcctc ctttgattcg aggtcaaaga gaccccctaa agtccgctaa 3310021 acgagaagcc atattttcga gctctgctct aatttctgat aattccattt cattcacctc 3310081 attaaaagat ccgcaggcgc ctgcaggcgc cgcggtcagt aaacttgccg gggcgaacta 3310141 ttcagtacgg ccgcagcaat ttttatattt tttcccgctt ccgcagtggc atggggcatt 3310201 tcgtccgata tcaaccactt tgcgaaccgg tgctttcttt gcttttttgt tatcgtcgcc 3310261 ttcttgcggc tgatgagctg ttgtttgacc ttgtacaacc tcttcacgct ccagattgtt 3310321 ttcaatctca gctttcatca caaattttgc gacttcgtcc tcaattgatt caatcatatg 3310381 ctcaaacatc gcaaaacctt ccatttgata ctcacgaagc gggttcgtct gcgcgtaagc 3310441 acgaaggtga atcccttggc ggagctgatc catcgcatca atatgatcca tccatttaga 3310501 atcaacggca cgaagaacga taactttttc gaattcgcgc atttgctctt tgccgaattg 3310561 ctcttccttc tcattatatt ttgtgatgat gcgatccata atgagctcaa gcatttcatc 3310621 cggttctttg ccgaagatat cgctcttctc aagtgcacct tcatcaagat aagttgtgtt 3310681 gataagatca actagaccgt caagcttcca ctcctcagga agctcttctc ttggcgtata 3310741 ggctgcaatt gcgcgttcga gagaagactt gatcatattt tcaacgattt cacgcaggtt 3310801 ttcagagtca atgacttcaa agcgctgctt ataaatgacc tcacgctgct ggcggagaac 3310861 atcatcatat tgcagaagct gtttacgcga atcgaagtta ttgccttcga cgcgtttttg 3310921 agacgattca accgcgcgag ataccatttt gctttggatt ggagtagagt cgtccatgcc 3310981 gaagcggtca agcatcgcca ttgtccgctc agctccgaat ctgcgcatca attcatcttc 3311041 catagaaaga taaaattgag taatccccgg gtctccctga cgtccggaac gacctcgaag 3311101 ctgattgtca atccggcgtg attcatgtcg ttctgttccg actacagcga gcccgccaag 3311161 ctcttttaca ccttcgccaa gcttaatgtc cgttccgcgc cccgccatgt tagtcgcaat 3311221 cgtaactgcg cctttttggc cggcctcttc aatgatctgc gcttcacgtt catggttttt 3311281 ggcatttaac acttgatgcg gaattccttt gtttttaagc agcttagaaa tcaattcaga 3311341 tgtttcaacg gcaaccgtac cgactagaac aggctgtccc gtcatgtaac gctgtgcgac 3311401 atcctccgca actgccttaa actttccttc catcgtgcgg taaattaaat ccgggcggtc 3311461 atcacggaca acaggcctgt tggtagggat cgtgacaacc tgcatgttgt agatgttgcg 3311521 gaattcttct tcctctgtct tagctgtacc cgtcataccg gcaagttttt cgtacattcg 3311581 gaagtagttt tggaacgtaa tcgtcgccaa ggtcatgctt tcgttttgaa tctcaagccc 3311641 ttcctttgct tcaatcgctt ggtgaagccc ctcactgtag cggcggcctt tcatcagacg 3311701 tcccgtgaag gaatcaacaa taacaacctg tccgtcttcc actacatagt caacgtcctt 3311761 ttgcatcgca acgtgagctt ttaaggcctg gttgatatgg tggttgagcg cgacatgctt 3311821 cacatcaaag aggttatcga tgccgaatgc tttttccgcc ttcgtcattc cttcttcagt 3311881 aagctgtaca gcttttgttt tgatatcgta cgtgtaatcc ttctccgctt ttaacgtgcg 3311941 gacaaaagca tttgcctgta cgtacagctt agtggatttt gcagcttgtc cagaaatgat 3312001 aagcggtgtt cttgcttcat caattaaaat agagtcaact tcatctatta ccgcaaaatg 3312061 aagcgggcgc tgaaccatct gctctttata aagaaccata ttgtcacgca aatagtcgaa 3312121 gccaagctcg ttgtttgtgg agtaagtaat atcagcggca taagcttccc gtttttcgtc 3312181 ttttgacatt gagtttaaat tcaaaccgac agtcaaaccg agaaactcga aaattttccc 3312241 catttgctca gcgtcacggc ttgccaagta ttcgttgaca gtcacgacgt gtacgccttt 3312301 accggttaac gcatttaaat aaacaggcag ggtagacgtt aatgttttcc cttcccctgt 3312361 tttcatttcc gctatatttc cgtcatgaag cgccacgccc cccatgagct ggactttaaa 3312421 cggaaacatg cctgttacgc ggcgtgaagc ttctcgaaca acagcgaaag cttcaacaag 3312481 aagatcatcc gttgtcgccc ctttttcaag acgctcttta aattcaattg ttttatgttt 3312541 caatgcgtcg tcagagagat tttcatagtc tccgcgaatc gcatcaatat cgttagcaat 3312601 tttttcgtat ctattcagcg tacgttttgt tggatcaaac attttattta aaattccaag 3312661 catttataac gctcctctat catcacacgc ctattttaga ggcatgtata aataatttac 3312721 tagtccatgt atacctctca ttatcatatc ataccttttg ttatttccaa agaatttgca 3312781 aataagaaaa acaaaaacct tccgcggaca tcacggaagg cttctcttca ttattcagtc 3312841 ggttcaatta agccatattt cccgtcattt ctgcggtaca cgacatttgt aaggtttgtt 3312901 tccgcatttg tgaaaacaaa gaaattatgg ccgagcatat tcatttgcaa gatcgcttct 3312961 tcactatcca tcggctttaa attaaagcgt ttctgacgga cgatgtccaa gctctcctcc 3313021 tcttctatgt catcctgaac cgcaatatct gtatcagagc caagaccgtt tgccaataaa 3313081 tattttggag agccctgctc acggaattta cggtttactt tcgttttatg cttacggatt 3313141 tgacgttcca gtttgtttgt tgcgagatca attgcgttgt acatatcctc gttatgcacc 3313201 tcggaccgaa gcgccagatc tgtcatcgga atcgtaacct caaccttaga ctccttgtca 3313261 ttgtaaaact tcaagttgac gttcacatca gcatccacgc tatggtcaaa atagcgctcc 3313321 agcttgccga tcttcctctc gacatgatcc tttaacgcgg gtgtcacttc aatattttct 3313381 cctctgatgt tatagttcat caaagaacgc ctccctttta ttaaggatat gtatctattt 3313441 ctcttttacc ctttacaatt cctgctgaaa cataaatctt ttgtgaaaat tcagtgaact 3313501 ttgtcgaatt ttgtttgtat ttgctctgtt attggcggtt cggaggtata tgtatatgct 3313561 gattgaacga aacaaatacc tcacacacgc ctaattgatt aaaaagggtt ccatacattg 3313621 atgaatagac agcatccatt ttctataatg aatcagaaaa tgttccttta aatactcaca 3313681 gaactcatga gagggaaaag agaaagagac caattgatca aactccgcaa aaatttggtc 3313741 aaatgctttc acacaaattt cagcacaccg cgaatccata atgaagagaa gtgttgaatg 3313801 tgttgaatcc aaataaaaaa aggcttggat cagatcttgg tagatccgat ccccttctgt 3313861 ttttgataaa ttctcttcag cctctatcaa ataacacaac ccctcttcga tggtaaaaag 3313921 aagatgataa taagctgata aaagcgtata atcttcaatg ctcttcaagg cactcaccta 3313981 tttacgcttg tcataatatg tgccgtcaat cgtaatgttg ttataagggt ttaaatacgt 3314041 cgtatgcatc acacgttttc ttttcatctg ctgaagttct gttgcgattg actgcttcag 3314101 tctttccatt tccttcacaa tcagctgatc ccatgtcaaa ataagtttca tctgctttcg 3314161 ctcttcttct gaaagcggca gagatatctc ctgaatcagt tcagaccgtg tagccacaaa 3314221 gtcttcaatt tgctttaaaa gttcatcgct ttccggcgta ttttgtatgt gtgacagcat 3314281 actcttcgtc tcagtgtata gttgatctat attattcatg cgatcccgcc tgatccgtgc 3314341 cggtccttcc gctcactttg aatggcttgt ttccaagcat cgcgaaaatc tgttacataa 3314401 ccttcaacct cagccagcat gcccgtatca tttttgatat ttgcctgtac caatctgcga 3314461 tacatataat cgtacatcgc acccatagaa gcggaaagct ctatgttacg gttaagtgta 3314521 aaatttaatt cctgaataat attttgcgct ttaatcagat tttcattttt acgttccata 3314581 tcatcattct caatggcctg agcggcaagt cttataaatt tcaaacagcc attatacagc 3314641 ataagcgtca gctccccggg tgtagccgta ttcactgaat tttgctgata ggctgtatat 3314701 ggattttgga tcgccatgtg tcatcctcca aattacattt attgtacaag aagctgtgat 3314761 aaataggacg cttgttcgtt cattttttga atcgcagaat ccattgcact gaattttgaa 3314821 taatagcggt tttctatggt attcaatctg tcctgcatat cagttatttc agtacttatc 3314881 gagtttaaat tttttccaat ggaatagcta ctagctccca ttgtcgagtt cccagcttta 3314941 gcttcaatac ttttcacagt acttctaagt gtattagtaa tccgcttcat aataccttta 3315001 tcgctatagt tactatcatt tgttccactt gtaaaaagat tagcaactcc ttgaggatct 3315061 tctgctattt ttgctttcaa tttctcttcg ttaatctcta agtgccctcg cagttggtaa 3315121 gcacttgaag ttgtgatgcc aaattcagtt aattgatagg ttttcccatc cgcattcact 3315181 tgagtataaa agtcagtccg catttggttc gtgccagtgc tgatgcttga atcgtttctc 3315241 agcaatccgc ttttcgcctt ctcctcccag agctctacct ctttatcgga catggcttct 3315301 ttttgttcac tcgtgagtgg cgtatagtct cggtattttt cttctttcag cttttcattc 3315361 aggctgtcaa ccagttcatt gtatttatct acaaactctt tgatttggtt ataaatccca 3315421 tcaacatcag tagaaacaga tgtggtaaca gggcctgtgg ctgcagttgt atttttaatc 3315481 gaataagtaa caccattcac cgtgaaattg tttgtcagct tctccatttc aaagccgttg 3315541 attgtgactt tggcatttgt gccttctttg taagcagtaa gcttattatc agcatccaaa 3315601 gaaaaaccaa gctgaccgga cataaagtca gctgtagcag agtctgctgc ctgtatgctt 3315661 cctcctgcac ctgttgcttt agaagaaaac gcaatcgttt ctacgtactc tgtaccattc 3315721 caaattttat ctttaaatgc tgatactcct agatctgagc tgttaagttt agaaatcaca 3315781 ttatcaatcg tatcggcact cgtcacacta atgttcactg tttttgctgt tgtttcgcca 3315841 ggcgcaacaa cgttaaatgc caaattgtaa tcgccttgtg tgtatcccgt ataattgttt 3315901 gccttatacg ttgctgcagt tgccaagctc gccacttcaa cagtagacga agaatttggc 3315961 gcacttacgc ttcctgtagc agttaacaca gactcattag agcttgtcac agttttgctc 3316021 tgatacgtgc tcggatatgt caacgtattt ttagacatat aatcttgcaa ttcttttatt 3316081 tttgagttta cttcacgata gctgtcacgc tgccattcaa gagtctgctt tttttgtgtc 3316141 agcttatcaa gcggcgctct ttctgtctgc atcagctttg atacgatatc atctatatcc 3316201 attcctgacg ccagacctgt tattcttgtg accatctcaa accactccta ttctactttt 3316261 tttcatctac aaataaccca agaaattcag tcatagccgc ataaaaatca agccaccgtt 3316321 ttggtggaat ttcgcggatc acttcatttg tagagtcctc tattaccttt acatagtatt 3316381 catttaactt gtcatgaagc tcgaacttca gatgaacttg cgaaggttcc aaaagcttgt 3316441 tcatttcccc caccatttca gcaagattgg tatatgaaac ttgatgaaca ggaacctcgt 3316501 tatcattatc tttctgatta tgtatttgag tatcataacg atcccaaaca ggttgtaacg 3316561 tagtgagcct ttcaatgttc aattgatcat cccctatgcc ccaatctatc gtttatatcg 3316621 actaagtcga gataagatta cacatatttt tggaaaaaaa tcttctgttt tagatttctt 3316681 gtatggaaat acatttataa aaagttagtg gagaatccgg ttattatatc atgagttagt 3316741 gacaggatga ggaatgatta ggagatagaa atttaaatta aaagaccctg gcaacgccaa 3316801 ggtctttttt aaaattaacg taataattga agtacgtttt gcggctgttg gtttgcttga 3316861 gcaagcatag cttgagaagc ctgagaaaga atgttgttct ttgtgaattc gctcatctct 3316921 ttagccatgt caacgtcacg gatacgagac tcagcagctg tcaagttttc accagaagcg 3316981 cttaagttgt taattgtgtg ctctagacga ttttgtaccg caccaagctt agcacgttga 3317041 gaagaaactt ggttgatcgc ttcatcaaca actttcaatt gagcatcgaa accgatatca 3317101 gcagtatctg ctgcattatc tgcgaatttt gttacgtcaa gatcattaac tgaatgaaga 3317161 gctgcaattg aaccatcagc ttctttaatt ccaagagcgt cagcacccat atcctcaata 3317221 tttacagaga tttgctgtgt agcatttgct ccgatttgga ataccaagtt cttttgattt 3317281 gcaggagtag ctgtgtcaac tttgtaagtg ccatcgagca atttcttacc attgaattct 3317341 gtacgatttg aaataccatc gatttcatct gttaaagctg aaatttcatc ttgaatagat 3317401 tgcaaatcag ttgctttgtc ctgagttcca gtgtttccag cttgaacaac tagctcacga 3317461 acacgttgaa ggatcgcatg agtttcagtt aatgcaccct cagctgtttg gataagagag 3317521 attccgtctt gagagttttt agaagccatt tcaagacctc tgatttgtcc tctcattttt 3317581 tcagagatcg caagacctgc tgcgtcatct cccgcacggt tgatgcgaag acctgaagaa 3317641 agtttctcca tgttcttttg gctcgcactg ttgtttgaag acaaacggtt cagtgtgtta 3317701 agcgctgcaa tattgtggtt aattctcatt gttttgttcc tccctgaata tgttgttaag 3317761 gcacgtcctt gtgcccttat tttgtaactg gctgagtctt ttgcgcctcc tcccggctac 3317821 atcattaata tcggattgtc tctgattttg ttaatacaaa aataaaaaaa tcctcacttt 3317881 ttttgtgagg ataatgcgga gatcacatcg ctggataacg ctgctgcacg gttattttct 3317941 tcctgaatgg tcaagtaaat ttctttcctg tgaatatcaa tatgctttgg ggcgtcaatt 3318001 ccaagcttca cttgatcccc ttcaaccgca atcactttta cttcaatatc agcacctatt 3318061 tgaatcgctt cgtttatttt ccgcgataaa actagcatga ttctcctcca atcggatgct 3318121 ttgtcgtata tgaggagtcg tgtaaaacga cttgcttagc catcatgttc ttgcgattca 3318181 caataatggg agccaataaa ttcgcagtag acttttcaaa tggctctgcc atagtcaata 3318241 ttgtcatgac ttctacgtct tgaatattat cgatatccaa aagttcagca gttgattcat 3318301 caagatcaaa ttcataattc ttaaaaaaga taaacggact tacgacgata aacgcaagat 3318361 tttctgaagt gacggactgc agtgccacga atggagagtc ttctgaaagc ggaagtatga 3318421 cgaactgttt ttcttctaaa aagcctggaa tcccgctttc aaaaagaatg atttgttctt 3318481 cttttatgtt catttggcca tggtacttcg tatgaatgat cattgttcac gatccttttc 3318541 tttttacttt tcgggtgatt ctttcgggta ttctacatct atatttaaat cagggtattg 3318601 aagcatgtca accttaacat ttcctggcgt atattcaaca attggcttat gcggctcagc 3318661 ctgaataaca ggctttcgcg gcgtaatctg cacatcaagc tgtgacggag tatattgtat 3318721 tttcaccctc gaaagagaag gagcataatt ttcgcctaat tgaatttggt gcatttcaga 3318781 gttcctcctt gcttgtgaag cgattgggtt ccccttattt tcaatcttca taagctcgtc 3318841 gccttcttct gcagtgcgtg ctattccctc cattacatcc tcatgccctt gttgggcggc 3318901 ttcttcaatt ctcttgaaaa catgctttct gtctaattct tcccatgctt gtgtctggtc 3318961 aatcgtgagt tttccaggtg tcaccgatat ttccatttcc gcactcggct gttcgatctc 3319021 tagatcagct tgaggctgct ccatttttaa gctggcaggc gtcgttgtta aaccaatttt 3319081 tccttgaaca ctatgcataa tcaatctggg aatctgcatc actctacctc ctgaactata 3319141 aaaaaagcga actcctaaga gccgcttact ttaaaaagtc aatcaatgta ggctgaacaa 3319201 tttgcgcatt aacggccaga gtagccctgt gcacactttg ctgcgcaata aattcagtta 3319261 ttacttcttc cagttctaca tcttcattgt ctgataacac tttggtagct gtttcttctt 3319321 gcgctgacag tcttgtatta accagttcaa gacgattata tctcgctcca agatcagatc 3319381 gttcagcgct catgccgtca gaaaaatgat caatatcatt taaaacactg tccatgccat 3319441 ctagcgaacc agaatttagt gctttctcaa aagaatcaag catttcaaat acattctgcc 3319501 cgctttcaga agtgcctcca aaagctgact ttggatctga attcactttc aatgacatat 3319561 tatttgatat attgactacg acatcagctg tatcagaaat tgtataagtt ccgtctccgt 3319621 tatctgtaac cggaggctta tctgaatttg tgccattaaa gatatatctg ccgttcactt 3319681 gtgtattcgc aatatttaaa agctgttcct ttaactgctt tacctctacg ccaatcgctt 3319741 gccgctccgg ctcgccgttt gtatcatttt gagcttcaac cgctaattct ctgacctttg 3319801 acaagatgtc aattccttct gtaatgtttg tttctgtgtt ttcgagccag gtaaaggctt 3319861 gagaagcatt gcttttgtac tgctgcactt gagacagttg cgtattatac tttaagcttt 3319921 tcattgctac tacaggatcg tcggaagctt ttgagatttt ttttcctgaa gaaatctgcg 3319981 actggagttt atccagcttc gagtagcttg aaccgatata tctcagtgag ttttgctgta 3320041 tcatgccttg tgttactctc atgtgactct acctaccttc ctccaacacc catgccgttg 3320101 atcactttat caagcaattc gtcttgtaaa gtcaccattc ttgcagctgc attgtatgcg 3320161 tgttggaatt gaatcatatt cgtcatttct tcgtctaaag aaactgcgct catttgctga 3320221 cggtttatgt cagcatcatt cagctgtgtt tctgtattag acgccagtcg attagcctct 3320281 tgagcttcga tccctagctc gccaatcaga cccgcataat aatctaaaac actagtttct 3320341 ttaccgttaa tggttatttt accggttaaa acatttgcta attttgtagc atttgcgtta 3320401 tcgttggctg cgccagtcag tgagaaagca atgtttgcgc cttttgaatc tattatgctg 3320461 tcagccactt tgatcttgcc cgccgcgccc ttggcaggtt cagtttcacc gccagtaaaa 3320521 tcaaaaaagt ctccgccttg ttcaccgctc ttggtcacac catttctgtg cacttcattg 3320581 aaagctttcg cgaattcaag cgccatattg tcaagatcag aaagcatttc cgggtatacg 3320641 cccttttctt ggccatctgc tgttatatac ccataagact ctataaaccc taaaagggat 3320701 cccttgctgc taaaggactc cgcctgtaca gctgtatccc cgattgaaat acttgatact 3320761 aacccagttt cattatcata gttggctgca agttctgaaa cctcgtaatt tttaccgtcc 3320821 aaaacagttc ctagcgactg tttattttta tcaaggattt caattgatac agttccttca 3320881 gcagatgcaa gtgcattccc gcctgatttg ttgtagctga ctttgatatc aaccattgag 3320941 gataatttat cgatcagcaa atctcgctgg tcatataagc cattcggaag aagcccgacc 3321001 ggctctactt gtgcaatttg cttatttaaa ctgtttaact gagaaagcag agaattgaca 3321061 tccaacacag ttgtatttag ctctgctttt aaattcgatt ggacatttgt aagtgattca 3321121 gaaatataat taaacgtttc agctacagct tgtccttttc gagcaacaac agaacgtgca 3321181 ctttcttcat ttgtattatt cgataattcc tgcagggaat tccaaaacga attgagcaca 3321241 ctgttcaagc cgctgtcatc cgtttcattt aaaacgcctt ccatttggga cagcgctttt 3321301 gccttcgtgt catagtatcc ggcactgttg ttttgaagac ggtattggta gtcaagaaag 3321361 atatctctta ttctctcaac tgattttcct tgaacgcccg tacccatttg tcccgctgtt 3321421 ttttctgcat ttttagatac agcagggaaa tagtcagttg cctccaatga gacccgctgt 3321481 cttgtataac catcagtatt ggcatttgcc acgttatttg cagtagtgct taacgctgcc 3321541 tgctgagcgc ttaacgcccg ccttgcagtt tcaagcccca taaaggtaga tgtcattttc 3321601 tgaattcctt tctgctaagc ttttgaatca aacagtttca ttttgctact tttcggcagc 3321661 tcagctttaa ttgatttgct gtaattgaag ttattttcct taggaaccag catatcgtac 3321721 gaaatagaga tgaattgcag cgcgtctctt gtcagctgcc tattcatctc atttactttt 3321781 ttcagacgtc cgagaacttg agaaagagat tcgtatagtt gttccagctc ttccttttca 3321841 ctgcctgagg ttttggcgat acatgcggaa atagtattat tttcgctata tccgagaaag 3321901 gccgaagttg ttttgatccg gtcatcttct gtctgcgtga ttgcttgaat atatttttgc 3321961 tcttttgtca aaatgttaga aagctctttt gttttgccgg ctttgagcgc ttccgtcttt 3322021 tcttcagaca gcgtgagcag gtgctcatgc agaacgcaaa gtcgcttcaa ttgttcaata 3322081 attgccttcg ctgacatggg ctttctcctt ttttattgct ttttataaaa attaatcata 3322141 tttttcgcaa tatgatttgc gtctactttg tatgacccgt tttcaatttg cgctttaagc 3322201 tgcgcaattt tttcctgtcg tgaaccagtg actgcgtcgg atgcatgttg catttcttta 3322261 gcctgtgatg aaatttcaat tttatcttga ggttgtgcaa cagttttttg caccgcttgc 3322321 ttatcataat ttttttgata tggattaacg gattgtgttc caaattgatt gattttcata 3322381 ggattcctct cgctttccgt tgcagtcttt aaacaatctt aaccctttta tcgactgcgt 3322441 tttcagttag tttagggaat cagctgtttt tggtattata ggcatagtat gtgtcttttt 3322501 tactattttc tttctcgatt ttcagagcat cctcgtggtt caaatgatcc atttgatcct 3322561 taatatcaga ctggcaagcc ttgcagaact tgccttctct aatcgatgtc ccgcaccttt 3322621 cacaagggta tgccaaatta ggaagatgag tgatctgaat tcgcttctgc ctgatgaatt 3322681 tcaatatcag ctcttcttcc acacctgttt cctcagttat ccggctcaaa gttgattgcc 3322741 ggttttcctg ttttcttaaa aatttataga cagtctcaaa tgatttttct tcttccttaa 3322801 tacacgcctg acatacggtt tgcagctttg tttttaaaaa taaagcattg catttcggac 3322861 aattagccag ttctcccatc tttttttctc cttattagat aatatgcctg tgtcaatttc 3322921 tagtgattat atcggcataa aaacagaatc atttagcttc tgatcaaggt aaaagatgac 3322981 actgaagcgg cttttccttt ttctaataag cagcgggctg cgaagtgcaa ggtggcgcct 3323041 gttgtataaa gatcgtctat taaaatgata ttcatacctt ctgctgaatt attttttgta 3323101 tcaaaaatgc actctgacag caggcgttct gttttctttt tctttgactg tttctcatta 3323161 ttcaggcgaa tgaggggatg gtgggaaggc cggtctaaac attctgccaa gagatgtgcc 3323221 tggttaaatc cgcgctcttc ttcccgttcc ttgctcagcg gaataggtac aagaacaaaa 3323281 tgcttatcgg ggtaaacctt agaaaaggtt gaagaaaaat cacttttaaa tgcatttatg 3323341 atttctgcat ctcctctaaa tttaaaacgg gagagcgttt ctttcatcat atcattatat 3323401 gtgtaaactg aacggttttg acgcaatagc aaactgtctc tgatccttgt tctccacacc 3323461 tcgcaatccc tgcatacggc atgaacagat tgaggtctgc cgcacagggg gcagatatgt 3323521 cctgtgattt tctttaattt gcttctgcaa gaataacaaa ccttttcatc aggctttagt 3323581 aaaaaaaggg ctctccatgt aacatcttga gaaaattgcg aatcacataa taaacagatc 3323641 agtttatgaa tgcctcctcc tgcttcgttt gacataaatc gcttggactc tctgaaacta 3323701 ctgcagcaga ttcagccaaa atgacaagca ttgctgtgtt tttttgttta tctaccagct 3323761 cagctttcgt atatgcgatc tttttaaaat cagtaacgta ggatggactc actttgttta 3323821 aagaaagtgc caatacatcg ttttggcata cttggcaagt acaggccata tgaagctggt 3323881 ccatatatcg gtcgagcagt tctttcatta cgatttcttt tgaattgaca agcattttta 3323941 cagctcctca tcatcggtta tatgagtata ctgtaccacg ttttcaaata atggctagtc 3324001 tgtacattca acttttgctg ccaattcatt catttctttt atatgctttc ttgcatcgag 3324061 catactcttt gttttgccga agtgaaagta aatgacatcg ccgtccgcat attctttatg 3324121 ccggccggtt cttcctgcaa tttgaacaag tgcgctttcc gtaaagatag acgattccgc 3324181 tcctagtaca cccgtttgca ccttggggac tgtgacgcct ctttccagta ttgttgttgt 3324241 gattaataga tcgagctgac catctctgaa ttgctgcact ttctcctttc tatgcttgtc 3324301 ttccgcgtgc acagatgcgg ttcggcaatg aacaccttta aagcacgcag cagccttttc 3324361 cagaatagaa acggaaggaa cgaataaaaa aacaggcctc ccttctttta catgaaactc 3324421 tatccatctt ttcaccgctg gcggaatttt atttcggttt aatttcttct tccagtttcc 3324481 acaccataca aagcgcggtt cgggtaaagg tttccggtgg tgtcttgcgg ggatgcgaac 3324541 tgaatgtaac tgtccgttca gtgcttttct ttttaattct ttaggaggtg ttgcacttaa 3324601 ataaacgagg gtgctgtttt tctttcttgc tttttgaaca gcgaattgaa gggtttgatc 3324661 agcagaatat ggaaaagcgt caacttcatc aatgatcata acatcgattg catctttata 3324721 tcgcaaaagc tgatgcgtag tggaaatcat aagcggagat agccgccctt tgtcatcgct 3324781 tcctccgtaa agcgctgaaa tgtcagcacc ctgaaaggca gccttgagtc ttggagcaag 3324841 ctctaataca acatcggtgc gaggtgttgc aatacataca cgcagtcctt gatttaacgc 3324901 tgattctata ccaggaaaca gcatttctgt tttgccagcg ccgcaaaccg cccagatgag 3324961 gagctcttct ttttttgata ttgcttcaat taaaacattg gcggcttttt gctgtccgct 3325021 tgaaagcttg ccatcccatg tcagcttaat agacttccag tttgattcat tttcctcttt 3325081 ccatgaatat aaaggaacct cctcactcac tctgcccatc atgacacagg aacggcaata 3325141 cagcttattc tttccagatg agtgataaaa agaaaaatac cgctgatcag tttgtccgca 3325201 cctattacat ctatatctcc gtttatttat ggatatagaa ttttcagcag tgatatatcc 3325261 attcttgata tgccattcaa tcatctcatc ggaaaatgag agctcagtcc tgagcaaatg 3325321 acggcttcga agcgtctgct gcaattcttt tgaaaaggaa ctgttttttt caactggcac 3325381 attcacatag cacgcctcct ttcgaaacag tatgcctgaa tgaatatttt ctgtccaact 3325441 attaaaataa gaatataaaa aaatctccgc tctaaaaacg gagatttggc cttatttaaa 3325501 acaccagcaa attcctaacg caccttcacc caaatgagtg ccgattaccg cgccaaaata 3325561 gctgttataa aattcaacat gaggatattt tgcagaaagc tcttcaatga ttttcgctgc 3325621 ttcttcctct cgattagcgt ggataacagc agctcgcata ggcaaccctt tactcgcatc 3325681 ttcgtctaaa agctcataaa ttcgcgaaat tgctttttta cgtgtgcgaa tcttctcaaa 3325741 aggcacaatt accttattgt caaaatgaag gataggcttt acctttagaa gactaccaat 3325801 gaaggcttgg gcgctgctta atcgcccgcc gcgctgaaga tgggctaagt catctaccat 3325861 aaaataagct cgaactgttt ttttcatttc ttccagttct tttataatat cttccggcga 3325921 tgatgctccg tttttgatta attcagcagc tttaagggca taaaagcctt gagccaagca 3325981 gctgatctct gagtcaaatg gatacacatc aatattgtcg accatcgaat cagccgctgc 3326041 tgcactgctg aatgttccgc tgatcccgct ggaaagatgg atactgataa ccgcatcata 3326101 agacttgcca agctcttcat acaacgcaac cagctcgccg attggcggct gagaagtcgt 3326161 cgggagctca ttatgttttt tcacttcttc ataaaagctt ttccagtcca actcaatttc 3326221 ttcacggtaa gtctcctccc taaaaacaac ctggagaggg atcatatgta tctgatgttg 3326281 ttcacgcatt tctttcggaa tatatgccgt gctgtctgtt acgactgcaa tattcatagc 3326341 ttcgatacct gccttattgc tttataactc tattgtaagg gaaacggcag cctaaaaaaa 3326401 gacctgccta gtaaaaggca agtctcctat tatactatct catttctacc cagccatttt 3326461 taatggcgac cacaacggct tgcgtccggt cgtttacatt cattttttgt aaaatattgc 3326521 tgacatggtt tttaacggtt ttctcactga taaacaatga ttcaccaata ccgcggttgc 3326581 tttttccgtc tgcaagcatc tgcagcactt cacattcccg cctagttaaa atatgtaatg 3326641 gtctgcggat ttcagggtaa acctcatgtt gagggtgtgc agaaactccg cttgttgcaa 3326701 ggcggcggaa ttcgttaacg aggttgtgag taaccttcgg atggaggtaa gatccgccct 3326761 cagccactac tttaaccgct tcaattaatg tatcagcatc catctctttc agcagataac 3326821 ctcttgcacc tgttttcagg gcatgtgtta cataattttc gtcatcgtga attgatagaa 3326881 taattacttt agattcagga tacagctcta caagctgttt tgtagcttcc acaccattta 3326941 cgtttggcat attgatatcc atgatcacaa catcaggatg atagtgctca acaatacgag 3327001 ccgcttcgtc cccgtcatca ccttcggcta ccacttcaaa ggtaggttca aaatccaata 3327061 tccgtttaac accttcacga aataactgat ggtcgtcgat aataacaatg tttactttag 3327121 tcacaagcca cgcctccttg tattattgtt ctatatactc tagcattcgg tcaatatgcc 3327181 ttttggctct attttacaaa tcatagtcaa agagataacg gaaccttaat cataataaat 3327241 gtcccaagac ctattttcga atctattgtc atcgttcctt ccaataaatc tactctttct 3327301 ttcatgccca gcaagccgaa tgatttgttt ttcttctctt tcgcttcctt caggtcgaac 3327361 cctttaccgt tatcttttat cattaaaatc acaaaatcct ttgtgatctc aactttgact 3327421 gtaatttctt cagattcaga atgctttagc gcattagaca cagcttcctg tgcgagcctg 3327481 aagagcgcaa cctcaaactg aggcgctagc ctctgatcct ctgtttctcc aatgcactga 3327541 aaatgtattt tgaccttccc gttatattcc tcggttgtat atagatattt tcttaaagtt 3327601 ggaatcaggc ctaggtcatc aagggccatc ggtcttaaat catatataat ccttctcact 3327661 tcgtaaaggg cattccgaac attttggcgg agatttttaa tttcttggaa tccgtcctct 3327721 gcgccccggt cacggaaaat ccgctcgatt aattccgatc tcatcataac attcgccagc 3327781 atttgagcgg gtccgtcatg gatttctctt gagactcttt ttcgctcttc ttcctgcgcc 3327841 tcaataattc ttaagccgaa atcctgtttt gcctgagcat cagcaagaag cagtccaact 3327901 tcgcgcaaat cctgattcaa gtagttgagc acaactgtaa tttggcttac taatgattct 3327961 gaccgctcaa tgatttcctg aagccctagc aatctgcgct ccaaatcgtc ccgccgttcg 3328021 cgcaattgct tctcacgctg ctggatcatc gtcaattcta cctgcagctt atgggctttt 3328081 tcataagcat tgcggatttc ctcttcactg aatctatgaa aattacggct gacctcggat 3328141 aaacggtttc tcgcatggcg agtttgcact tcaagtttat cgccaagctc aatcacttca 3328201 tacacctgct gtttaatttg tttcagttct tcgaccagct gttcatactg ctggcgtgac 3328261 tgctccccga tttgaaaaac ctcgtccttg ctcccgtcaa cggttttcag catcttcatc 3328321 aaaatagaat ccagcacttt ggaatccatc tttgttttat tcataatttc cctccgtcac 3328381 ggcgttgtca tatattttta ttataaatgt aattgatctg caaattatgt cgaattataa 3328441 tgaaagaatg cgtatattct agaaaaaaac atttttatat actatctact ctttatgata 3328501 ccaaaatacg cacaaaaatt ctaaagactg tacgaatttg tataggcagt cttttatgct 3328561 tagcaggagg gtcagctagc atgctgcaca gctattttac tgtgaaagaa gcgggagaac 3328621 acgagattgt tatagaaaaa tcgcgtttta tctgtcattt aagccgtgtt tctaccgaac 3328681 aagaggcaca ggaatttata cagaaaataa agaaacagca ctggaatgcg actcataatt 3328741 gctcggctta tgttattggc gagaatgatc atatccaaaa agccaatgat gacggggaac 3328801 caagcggtac agcgggagtg ccgatgctcg aggttttaaa aaaacgcagg ctgaaggata 3328861 cttgcgccgt cgttacacgc tacttcggag gcattaagct tggtgctggc ggattaattc 3328921 gcgcttatgg gaaatcagtg tctgaaggat taaatcatat aggtgttgta gaacggaagc 3328981 ttatgcgaat catgcatact tctgcagatt acacatggct tggcaagatt gaaaatgaat 3329041 taagggagtc acaatttctg ttaaaggaaa tccattattc agaaaatgtt gaattcgaaa 3329101 catacgtgga agaaaaagaa accaacgctt tttctgaatg gatgacagaa ctgacaaatg 3329161 gaaagagtga tattaaagag ggagagttga cgtatcttga aaaagccgtc aatcacataa 3329221 aggagactga ataatggctg aacgcgttag agtgcgtgtg cgaaaaaaga aaaagagcaa 3329281 acgtaggaaa attttaaaaa gaataatgtt attgttcgcc cttgcactat tggtagttgt 3329341 agggcttggc gggtataaac tttataaaac cattaacgct gcggatgaat cgtacgatgc 3329401 cctatcccgc gggaataaat caaatcttcg caacgaagtt gtagacatga agaaaaaacc 3329461 attttctatt ttatttatgg gaatagagga ttacgcgact aaaggacaaa aagggagatc 3329521 agactctctt attgttgtta ccctggatcc caaaaataaa accatgaaaa tgctgagcat 3329581 tccgcgtgac acacgtgtgc aattagctgg tgacacaacg ggaagcaaga cgaagatcaa 3329641 tgccgcttac agcaaaggcg gtaaagatga aacagttgaa actgttgaaa acttcttgca 3329701 aatcccgatc gataaatatg tcacagttga ttttgacgga tttaaagatg tgattaatga 3329761 agtcggcggt attgatgttg acgtgccttt cgatttcgat gaaaaaagtg atgtagacga 3329821 aagcaaacgg atttacttca aaaaaggcga gatgcatttg aacggcgaag aagccttagc 3329881 atatgcccgg atgagaaaac aggataaacg cggagacttt ggccgtaatg acagacaaaa 3329941 acaaatctta aacgcgctga ttgaccgcat gtcaagtgca agcaacattg ctaaaattga 3330001 taaaatcgca gaaaaagcca gcgaaaacgt tgaaaccaat attcgcatta ctgaaggttt 3330061 agcgcttcag cagatttaca gcggctttac cagcaaaaaa atcgacacat tgagcattac 3330121 aggttctgat ttgtatttag ggcctaacaa cacatattac tttgaacctg atgctacaaa 3330181 tctcgagaaa gtcagaaaaa cgcttcaaga gcatttagat tatactcctg atacaagcac 3330241 tggcacttcc ggtaccgaag acgggactga cagctcaagc agttctggca gcactggcag 3330301 cactggcaca acaactgacg ggacgacgaa cggaagcagc tattcgaatg acagcagcac 3330361 aagctcaaac aacagtacaa cgaattcaac aactgattca tcctattaaa aaatgcccgg 3330421 tccttttaga ggatcgggca tttttgcgca gaaaaaaact ccggcacata agccggagtt 3330481 tttaattcct tttcaccagc cgtttataaa actttgtaaa cggcttaaat ttttcattca 3330541 cgagtcctgt cacttctgct atgatttgca taaaaataat caaaatgaag ataataaaca 3330601 aagaaagcca aattgtggca cttttaagta caatcgcact gatactgaaa ataaatccaa 3330661 ttaaataaat aactaagacc gacatccgat gtgaaaggcc aaaggccatc agtctatggt 3330721 gaatatgcga cttatcaggc gctgaaatcg gctgtttgtt taatattctt ctgatgatag 3330781 caaatgttgt atcaaaaatc ggtacgccta atataataat cgggataacg atactgaaca 3330841 atgtgacact tttatacagg cctaataatg aaagaatcga gatactatac cctaaaaaca 3330901 gtgatcccgt atctcccata aagatttttg ccggatggaa gttgtaaaac aaaaacccca 3330961 gcgtgctggc aataacgact aatgagagtg acagaatgag cacttttccg ccggatagcg 3331021 ccatgacagc aatcgttgac aggccgataa cagaaagacc ggcagcaagg ccatccaatc 3331081 catcaatcag gttaattgcg ttcgtgatgc cgacaatcca taataccgtc agcggataag 3331141 ccatccatcc taactcaaat cgttctgtta aaaaaggtac tgagaaaaag tccattttta 3331201 agccagtgct tacaatcata atggctacac ctaattgaat caaaaactta acttttgcac 3331261 ttaattgata tttatcgtca agaataccta acacaataat gatgaatgct ccgactgtaa 3331321 ttgccgtcat ccttgtttct gtgtaaatac cggatgcaag cacgcctgca accaccccga 3331381 taaatatggc cagcccgccc atgcggggca tgattttgtc atgtactttt cgattgctgg 3331441 gctggtcaac tgcacctatt ttaatcgcaa tcctttttac gattggggtt atgattaaaa 3331501 ctgtcagcag cgagacaata aacgcaacaa caatgcgaat catgcgttcg tcaagcataa 3331561 agaagtctcc tttggaatta aatgaagtct ttatttatat agagaaccgt tccttccatt 3331621 ataccttctc cttagttatt ataacaagct tcatcaaaaa gaaacacgta taatcaaaaa 3331681 acgcgcatcc caatttatag gactacgcat gtttttgaat ccctgtatat ttcataattt 3331741 gtctaaataa gcaattccaa tcttgtgtcc gggcgatgtt tcggcgcatt tctttatagg 3331801 tctcgtctcc gttttgaccg agaacttttt cacaagcggc tataaaatca atcggatgat 3331861 cgccctctac atattcgtat acatacggct tttgcatttt tgaggttgac ggaagattag 3331921 tgcctacaac aggttttcct gccgctaaaa attcaaatag tttcagcgga aacacagctt 3331981 gattatacgg tgattgttta tatggcataa tgccaatgtc gataagctcc atataatgag 3332041 gcacttcttt tggatctgcc ggaccggtcc atatgacatt gggaagcctc agcagctctt 3332101 gaaacgaaac atcaccattg gtggcatccg ggccaaccca taaaaatgtc caatcaggct 3332161 tttgcagtgc cgcttcttta atcattttaa aatcgagctt cggtttaatc ccgccaataa 3332221 aacctaacac tattccttct ctcccctgca gtatactgcg atcgggagct tgtttatttg 3332281 cagaaaacag ctcatactcc acaccgtttt ccacagtatg aaccttttct cgtcctgcag 3332341 tcagtttttt gtctacttcc ttgtgaagat aatctgatga acaggttatt gaatctgctc 3332401 gttgtataat tctcagctct gccgatttaa tgacttttcg ccggaattca gacagcagat 3332461 ttgatcggcc gctgatcggc gcagcccata ggtcactgca gtcataaatg acctgatccc 3332521 aagaatacag cgaagacagc agcgggaatc cgggaaacgt gtaccataaa cagcagcgtt 3332581 caccgtttgc agaagcaggt gtaagctcat cgagtaatgg ggagagctta tgtctgtaaa 3332641 agacatctgt atatcgtccg aaacgaaaca tttttttctg cagcaggtct ttgacagcga 3332701 attgcctgat gccagaatgg acttcctgaa actctttccc ttgggcacgc ggagccggac 3332761 atacccaaat aacttccttc gtttcctcct gagcagctaa aaattctgcc agccggtgcc 3332821 ttctgtatct caattggtct tttccccatt cagcagtggc aacgatgaca tgaatgattg 3332881 cttcttttgt ttccaccttc atcacctttt ctctctgttt gcagctataa tctttttttc 3332941 accgcgtttt ttgcatattg aacaaaacac catgttgctt tcataaaatg aagccgttcg 3333001 atctccctgt agacaaacca cgtttttttc gcagccttcc atttgttgct ggaaattgaa 3333061 ttattgacaa gccgatattc agccaggcat tcattcattc cataggcagt aaatcctttt 3333121 tttaaaagag acagccatgt ggctaagtcc tgtctcgttc tgatattcgg catttggatc 3333181 tgtcccgttt gctccctgtc aatcatcacc gtcaagcagc cgataattgt atttttcagg 3333241 gcgtcatcgt acgtcaggct ttccggcgca tgaataaatt tatcgagcgg ggtcccgtcc 3333301 tgcgccatta agctgtagcc cgtgaaagag aacgcacagg agcgctccat cataaactca 3333361 agctgctttt ccagtttgtc ttttttccat ttgtcatcac tgtccaaaaa tgctacgtag 3333421 cgcccttgag cgcgttccaa cgctttgttg cgagcaaccg cagctccgga gttctcttcc 3333481 agatacacca catgaattct ttcgtctatt ttttcatact gctgtaaaat gtcgcgggtc 3333541 ccatccgttg agcaatcatc cacgataatc atttcccaat gaggatggct ctgatctaat 3333601 accgaatgaa ccgtgtcttc aatatagtca cgcgcattat aggaaggtgt aatgacagat 3333661 acgagaggtt tccaattggt catgatcaca tctccatcgt atgattttaa aaggattctc 3333721 tgaaaaattc aggaatgaca acgaacataa aggcaatcgt aaggccaatc ataacgccga 3333781 gaactgcttt ctttttcgga gacataccgc cgcctgctgt ctcacttacg gtttcggaat 3333841 cagtaacact tgccgctttc aggttaagct gtgtgttttt gagttcatat aaaaatctct 3333901 ctttatccac tttggaatcc tcgctcaccg actcgccttc aagcgcgtct atgctgctgc 3333961 ggatgacggc ttctctttct gcatacagct tttgatcgtt tttgaggaag gtggaggata 3334021 tggcgtttaa gacagattcc gttctatcct tatcctcgtc actatagctt aaagtcagta 3334081 acgatttgga ttccgtattg attgtaagct tctctttgat ctctgctaca tcttcatcct 3334141 tttcatcagg aagcgcctcc ttcaaaaagg agtcgctctt taatagaagc ggaatctctt 3334201 ctgtgctgtt ataaaccgga tgatcatagc tccccacagc caaagtatct tcagctgtat 3334261 agctcttttg atcagcgatc tgtgacggca ggatataccc cgccgcacct aatataattg 3334321 gcaccgctat gatccaaatg atattttttt ttatgcgacg ggctattctt atcaatatat 3334381 cgttcatata agtctccctg ctttttgtag tctgtttatc tgtacatcgg ctcaggcatt 3334441 tgtctggatc gccttaacac attcacggcg gcgatgacga gcgccataaa cacccaatgg 3334501 aaaaataaat ttgaaacaga gcttgggctg atacttgata ccaggaaact gaccatagcg 3334561 gtaataagtc cttctgtgat cagttttgac tgattttcta attttctttc ataaaacttg 3334621 taaagcaccc atatgaggta ggcataaacg gacaaatatc ccagcatgat gaacaaacca 3334681 aaattagcaa gaatttcaac aagccagtta tgcacctctg ccacattgtc agtatcatat 3334741 acagcataat gctcaagata ataggataca tttcctgccc cgactccgaa tccgtatgaa 3334801 tcaaggaaaa aatgccaagc gtttttcagc agatttgccc gagccacatt tgatggaagc 3334861 ctgtcatgaa atgaatgcag cgtctgcggg gccagaaaca gctcccaaaa ctttgaatag 3334921 attttgctgg cgaaaagaac tgcgaaaaga gcaattcccg ccgccgacag ccatatagcc 3334981 attctcttta aaacaggcgg caatacaatg aagatgtaga cagcaatacc tgcaaaaatg 3335041 cccagaaggc tggctcttga accagtggca aaaattaaat acaacgcaca gagcgagagc 3335101 acaaggccaa ttgccttgat gtatccattc ttaatgtttt tcatcatcgt gatgtaaaaa 3335161 aagaagctga tggataaaaa ggtcgcaaag tcattttgat taaaaaagac cgatgtcgga 3335221 taatgctgct tgtactccgg tccgctgtac aatgtggaac tcgcaagatg atggtgggtg 3335281 atatgattgt aaaaaccaat gatcatcaga aataccgtca tcaccagcca aatggcataa 3335341 acaatcatca gccgctccat tttttgcacg tacatgacaa taagataaat gaagaagatc 3335401 cccattgcca ataaggctaa atacttgagg ccaactgtta ccgacttggc ccacagcaga 3335461 gaaacaaggc catatataaa ccaaaaggcg aaaaagagta aaatcccttt tacttgcagc 3335521 ccatgccatc tttcaatatg ggttcgattc cgaaccatgc cgaaaatatg aaggcaaccc 3335581 gctgcaatga gcagaagccg gtaaaggaac aaactgaaaa atccaagatg aatggcaaaa 3335641 aatgcattat ttaaaaaagt gcaggcgatc aaaatataga ttacagccat aaagagccgt 3335701 tcttttgttg taaatgcggt tgcaagcgtc agtaaaaaca ggccaattgc caacaccgca 3335761 agcacagcag ccatctgcat gaaacctata tctttatgga tggctcccag caataggacg 3335821 actccaaata tagcagcggc cagtaacgct agcgtatgga ccgctgatcg tttgatactc 3335881 acatgtttaa cccctttcct gatgtttcag gagccggcgg ccgagcctag cagccggcag 3335941 cttcaaccaa gtaacacttt ttctttttat aaattgacgc ttcccaagtc tttagccaat 3336001 tcttcaagcg gcaagcccgg aaaatacttg tcagagggtt ccgttccccg aacagcggga 3336061 cggccgatag agtgataaat gtatccggct gcctgcatct cttcaagtga aaataaattt 3336121 ctgccgtcaa tgatgactgg ctgttttaag agggttttca cttttacaag ctccatttct 3336181 ttcacttccg gccaatccgt taaaatcagg catgcatcag tgtcttccat cgcagcatac 3336241 acatctgtgt aatactcgac ctgttcgcca aggatcgctg aagcttcagg aatagcaatc 3336301 ggatcgtatg cttttacatg ggcgcccagc tgctgcagca ttgggataat atcaagcgct 3336361 ggagcggatc tcacatcgtt cgtattcggt ttgaaggcta atcccaggac tgaaatggtt 3336421 ctccctttga cgcttcccat aacagtcaaa agtttatcta caatatgaac acgctgcttt 3336481 tcgttcgttt caatgacagc ttcgatgagc ttgaatggat agcctgccga ttttgcgatt 3336541 tgaagcagcg cggttgtatc ctttggaaaa catgaaccgc cgaatccaat accagcttta 3336601 aggaactttc tgccgatacg gctgtcaaga ccaacaccat cagcaacttt tgaaacgtct 3336661 gcgccgactc gctcacaaat gtttgcgata tcgttgataa aggaaatctt tgtcgccaga 3336721 aatgcattcg cggcgtattt aatcatttct gcactttcta ggtttgtttt aatgacagga 3336781 gcatggaatg gctgatgaag ttcctcaatg atggcagcgg ctttatgact tgttgaacca 3336841 atcacggcac gctccatatt catcgtgtca tgaatcgctg acccttcccg aaggaattca 3336901 gggttagata caacatcaaa tgagtatctc ccctttgagg ctttttgaac gatagattgc 3336961 accagtttcc ctgttccaac cgggactgtg cttttattta cgatcacttt gtagccgtta 3337021 agatgctcac cgattgtttt cgccgccgct ttgacgtacg ttaaatcagc ttcacctgtt 3337081 ttggacatag gcgttccgac tgcaatataa ataatatctg aggcccgaat ggcagacggg 3337141 atatcgttcg taaaggtcag gcgctgatcc agcacatttt tttcaactaa gtctgcaagc 3337201 cctggttcat agattgggat taccccattt ttcaggcttc tgatttttga ttcatcgata 3337261 tcacagcaaa caactttatt gccgatctcc gcaaagcaag tgcctgatac gagtcctaca 3337321 taacctgttc caatgacagc tatttttttc acagcgctca accctctcct gtaaaatgat 3337381 cttccaattt ataatggtcg cagtgtctta cgattaaacg gacgttttcg tgaccgtctg 3337441 atactgatga tgcaaggcct tggcgttttt tcctgcgtca aattgagcct gcacggtttc 3337501 atacaagtca tctgctactt ccggcttcca tatttgctca tgttcgtacc gagtgatcgc 3337561 ttccgccaag gcttgagcgg atttcggttt aatcagcaga tgttggtgct ttccgaataa 3337621 agacgacact ccgccaacat ccgtacaaat aacaggaacc cttagcgcca gcgcctcaat 3337681 cacaacagtc ggcatcccct cactgtaaga aggaagtacg aatagatctg ccgcaagtaa 3337741 atagtctctt acctgatgat tcgggacttg gcctgtgacg atatgcccct tctgcgtcag 3337801 cgtcgatttt gcgggaccat ccccgacaaa gactgcctta ggagagtcct gcagcgattc 3337861 gatcgcttca gacagttcaa aaatgccttt ctctctgacc agccggccga catagacagc 3337921 cagacgctga tcgagcggga gtccgagtct ttttctgatt tcctctttcg tctcctcatt 3337981 cccctgaaaa cggctgagct gtatgccgat tggcaaaacc gagctgtcaa agcccgaaag 3338041 ctttttggct tcttcctgaa gcttgtggct gactgctaaa acaactgacg cagaacctac 3338101 ggcacgcttg aaggctttaa acgcaccttt gctgtaatgc ggatagacat tcacatcact 3338161 gccatgcaag gtcaggacat aaggaatttg cgctgactct gacacgactg ccgcagcccc 3338221 gcccgatggc atggcaaaat gcgcatggat cagatccgga tataggtcgc gctgtttcat 3338281 tgtttttaaa acggctgatg cgattctccg atgaggctgc gcccacttca gctggccggg 3338341 aactgcccga tagaaaggcc ggtaaaccgg tatccccttt ctaatctcat actccggtct 3338401 gacatccttt tttcgatatg tctttttcag catgcggaca ggtgctgaat gaaaaggccg 3338461 tgggcatatc acagtgatat caagcccgag tttttgcagc tcttgcacct gtgtctcatg 3338521 aaacacaccc tctccgggtt tcatactgct cggatatacg cttgtgatcc acaaaatctt 3338581 catgacaaac gtccttttct tagtagtttg cttttcgttt gagggtacgc ttttaccaaa 3338641 agaaagagat agcacagcgc cccagccgca actgaaatgg ccagccgcat ttctgcctgc 3338701 atactgaagt gttcggtact gaggcttaca ccaaacgcga tgatgcccat cgccgcagta 3338761 atcagaaatg gcttcataat cgactggaaa taagctgaaa ggttaagctt gatgacatat 3338821 gccaaaagcc agcgcccaat caggaaatta acaacgctga taatggcata cacccatgcg 3338881 actgtcagca ggcttcccgt ctgtacagct gcaaacagtg ataatccgta cagcagcagc 3338941 acgccggaat cccaataaaa cgctaagtca gctcttcctt tagccagcaa cacagatcca 3339001 tttggattca tgagcactct tagtattccg acaatcgcaa gaacatttag gatcggaaca 3339061 gcagcaagcc atttttctcc gaaaaccgct gtgataaagg cgtctgacac agacacgagc 3339121 ccgattaaca gcggaaacga aacaagcgcc agcatttttg tcatattcag aaagccttct 3339181 ctgatcacgc tgttttcata tttgtttttt gcgaaaatag ggaatgccac ccgtgtgaca 3339241 atcggattga tcttcaaaac cggaatggtg acaatctgat aagcgaggtt ataaatcccc 3339301 aatgcttcag caccaataaa ccggccgatc aaaatcatgt cgatatttgc tcccagcctg 3339361 ttcacaagac gggatgaaag ctgaaaggct ccaaaagaaa agaaatcctt catgcctctc 3339421 aaatcaaaaa caaaagcagg atgccacttt tttcggtata cagcccaata taaaatccct 3339481 ttactggact gcagcaggac ttgagaaatc acgtacgcca aaatcgcatc catcataaaa 3339541 accgctatcg ctaaatatcc gaatgacaat acatttgaaa aaatctctat tttgcttaac 3339601 gtattaaaat gcagctgctt ttgcagcata tactgatatt gctgtccaat tggcgcgatc 3339661 aaaaacataa tcgccagaat ccgaaccaga aacaccagct cttctctttg ataaaatccc 3339721 gcaatgacag gactgctcac atataaaaga acaaacagca aaacgcccgt cataatgtta 3339781 agccaataca atgttgacag ctggcgctcc gtcgcgtcgt ctctctgaat taatgctgcg 3339841 ccaaaaccca tatcgagcac aatctgggcg aaaactgtaa ccgttgtgat catgccgaca 3339901 agcccaaatt ctgttaaggt catcatattt ccaagcaggg caaactgaac aatttgtatg 3339961 attgtaatac acatggttga aatacttgtc cactttgcac cgctcatgat ttgttttgta 3340021 atacttggca tcatattccc tacttctttt taagctcaga ttgatggtga ataatggaat 3340081 cccgttttat cttgcaccat cacccgtcca aactacttta caagttttta acataatttt 3340141 taattctaaa gtgaaagtca gattgcgaat gtaatataaa tcaaatatca gcttttcctt 3340201 cggcgtcata tcgtaaccgc cgttcacctg agcccagacg ctgtgtaaag cctggaatct 3340261 cattctggaa tttttccgta aatacgggcc gttccggacg agggccaatc atactcatat 3340321 cgcctttcag cacattaaac agctgaggaa gctcgtcaat tctcgttctt ctgataaaag 3340381 ctccgatcct tgtcacccgc ggatcttgct tctgtgccca aaccgcccca gacttctcgg 3340441 catctatttt catggaacga agcttataaa gcttaaatgg cttcccgcct ttccctacgc 3340501 gttcctgcgt ataaatggca ggccccggcg tctccaaaca aatcaaaatt gaaaataccg 3340561 caatcattgg cagcgcaatc gccaatccaa tgagcgcaaa ccaaatatcc attacgcgct 3340621 ttattgccaa ataacgagcc gtcttttcag ataatgtaaa agaatgtatt tgttgaactg 3340681 agaattcacg actcacattc atgcttttct ctgcactcac tgacacacac ctcacgattt 3340741 gtttgggatg ttatgatgac ctatgccagt cagtttagca gacggatgtt aattggatgt 3340801 aaatggtatg ttaagaagtg tgaattacgt gttttttctg ataaatgttg ttaatactct 3340861 tttactattt tatatacaag tcctatttgt tttaatcatt tcatataaaa aagagacaaa 3340921 tctgtgatta gatttgtctc tttcgattat ctgtaataag atactgtgcc gtcatgaata 3340981 gcttgtgcag ctttatcttt ataaaccgct tgcttcaatt tacttgcatc tgatgcatta 3341041 gtgataaagg cagtttcaac taaaacactc ggcattttag aatatttaat aacatagaaa 3341101 gcagctgttt ttactccccg gtctctcgtt ccaagattag ccgctaactt tggttgaatt 3341161 tgttcagcca gtctcttgct atttgcagct tgatatgttg tatcgtagta cgtctcactt 3341221 ccatttggtg atgagctatc attagcattt gcatgtatac tgagaaataa atctgcttgt 3341281 gcagaagctg ctttatttac tctctcctgt aaagaataaa aagtatcatt agatcttgac 3341341 agtactggaa gagcacctga agcatttagc tttgtattga ctcttttcgc tatatcaagg 3341401 ttgacttctt tctcaaggag tccattgccg attgctcctg aatcttgatc accgtgaccc 3341461 ggatcaataa agattgtttc acctacaact ggattcttta gctgattagc aacctttgtg 3341521 cttacggcag gagtgtttcc gataatcata aagtttgaca tgtttttact tccaataatt 3341581 ttacgggctc ctgtagataa attttcacca tttgtaagaa taagagattg cttcttctta 3341641 gctgccagtg tagctcctgc aatagagtca gggtagctga atccattgct tacatatacg 3341701 gtgcttgttg ataaattaag tttttgtacg atatttgcag caagctcata tctgtttgaa 3341761 ccgctaattc ttgtaggaga aggtaacttg ttgtataccg tattgctgat acttccagtg 3341821 cctcctacaa caacggtact cgaaattccc ttatctttta tcacagacgt agtcgcacta 3341881 tttatagatg ttttatttgt aaaaagaatt ggatacccgt ttttcgctgc ataagggatg 3341941 acggccggag cgtctgcata taagaagccg ttcaaaataa cagcttttga agtcgcaccc 3342001 atcgcttttg ccacccgtgc agccgtatca taacggttgc ttcctgcaat tcgtttaata 3342061 cttatcccca agcttttaat ctggttagca gtgttagaag aaacagcagg tgttccgcct 3342121 acaataatta catttttagt ctgcatctct ttcaatcttg ttttcgtttc atatgaaagc 3342181 ttatcagaat tagtgtaaag caatggcgca ttcttctggt aagcaagagg tgctgctgaa 3342241 atagcatctg cataggaact cccaccaaca attacagctg tacttgctgt tgaatacatt 3342301 tgctttgata tttgtacagc agtgccgtat ctattgcttc ccccaactct tttcactgag 3342361 ttatcggcca aagctgttgg cacaaaaagt atgagcccca gaaaacacat tgttaggact 3342421 tttatataag aacgcaattg atttcctcct taaatggcgt tatatcctaa aataatcaat 3342481 aacttgtcag agttgtacct ggatagtaaa atttcaaaat tgaactatat gaatctccag 3342541 cttctgctct tgcttttgct ccatattgac tcattccgat cccgtgacca tatcctttac 3342601 cgctgattgt gtactttgaa gtatcttttt ttacagtcac ataagtactt ttaaatacag 3342661 tcgctccaat cattgttctt aactcacttg ttggtacact aatggttgta attttgctca 3342721 agttatagga gccagtactg cttttaacaa aatacttcac tttcatcgat gctgtttttg 3342781 cacgctgccc ttgtgtcgtt ccactaaagc ttaaatcgtc aatacttgca attttgacag 3342841 aatcagcgct tgtttcttta tttttcaaga tccagttctt aactccggaa agtcttgcag 3342901 aatcagtttc agtcgctgaa gaccaccaag aagaaggctt cgttaagtcc aaagatttcg 3342961 tatctagctg ttgttttgac aaagtaagcg tccagcctat ttgaggatcc tttgtatctt 3343021 tttttgcaat caagtaaggt acacttgacg accacacttc attactagct tctgtgtaac 3343081 caccattact ggaagaataa gctgcagtta taagagatcc attatatttc agaactttcc 3343141 ccttcgtttg ctctaccgct ttattggtat tcgaattcca actgtagcca ccataaactt 3343201 gaaaagcggt tgtatcaggt acagtagttc ctgtttttgt tattgagtag gttcttgcag 3343261 cgacagtctg tgctttaaga gcctcaagtg accagctagc aggcatttca ttcggaatta 3343321 ctccttttaa gtaatcctca aatggaatat tctcatttac cggtcggata tatttagtag 3343381 actcaataga gaaattaacc gtgccaagat actgctttcc atcaagacta attctgtttg 3343441 aagtagaata gttttctggt ttaattctta gggagtttcc gtaagttttg atgttttcaa 3343501 ggtttaattt tccgctgttg atttttagat tataggtgcc accgtcagct aaataaaatt 3343561 catcagcaag tgaattctca acttcagcag aaattgaact ggtacttcca ataaagtcgt 3343621 atgcatatgt ggctttatct ttcgttatac ttttagccgc agccggaacg ctatcttgtt 3343681 taacaaataa aatttggctg tttttcttcg aggcaagcga agcgcctatc aatacgtctg 3343741 catattttgt cccgttcgtc attacgactt tatcagcctt caactttagt tgcttaatta 3343801 tatttgccgt aagttcatat ctggttgatc caggaatcct ttgcacagtt gaagtttttt 3343861 taatttggtt ttctacacta tcactgacgc taaatgaact gcctataatg atgacttgtt 3343921 ttggcaaatc ataatccgga agcttgtctt tctctgtaag caaaataggg tatccgtgtg 3343981 ctgctgcata tggagcaatg gctaaagcgt cttgaaatac tcttccggtt acaacgatcg 3344041 ctttatcata gctgcccatt tgctttgcaa tattttctga taagacatat ctattttttc 3344101 cgcttatcct tttcacagcg ccatatgatt tcagcttgtt ttctacgtct tttgaaatgc 3344161 ttcgcgctcc cccaatgatt aaaatattat cagggttaaa cttagcaatt tgtctttcag 3344221 tagtttttgt taacgtgtca ggctgagtaa ataaaactgg tgcgttcagt tttttcgcca 3344281 atggaataac aggcaatgca tcaataaaaa tatctcggtt caccaatatc actgtattag 3344341 gatttttcca ctggctgttg gatgcaagag tcgcagtttc gtatcgtgaa gcgcctgcaa 3344401 aacgatccgt aacagcaaca ttatctccag ttactttata aaatcctgtt ggcgatagac 3344461 tgatgctaga tttatttcca atataattta acaatttaac tgagatgttt gagtctgctg 3344521 caaaagaaac tgatggaatc aataataaga ttgcagcaag tgaacacact atcaattgtt 3344581 tgcaagattt caaaatttca ggttcctccc tatatcttag ttggcacgtt caatatcttt 3344641 taacagaagc tgaccctcat catttttttc atatgtaatc gtgaccttat ctccactgtt 3344701 aaacttatca agatcacttg tcgattcttc agtgatatca agactaaccg gctcattatc 3344761 tactgttact tctattgtat gagtatcagc taaccctaca taagtacctt cttttgtttc 3344821 aatgttactg tctggcgata catcttcacc ttgactcttt tgactattaa ccccgcaacc 3344881 cgaaagaagc aatataaaga acagtaaagc aataaatttt ttcatttttt tcacctcatt 3344941 atattttatc gtcaacctat tttatatttt aaagaaaaat taagaaacaa tgaaactttt 3345001 ttttataaaa aacgactatt ttaggatttc attcttgtat taaatagagt tgtatttatt 3345061 ggaaatttaa ctcataatga aagtaattta acagacgagg tgcaaaggat gagaaacgaa 3345121 cgcagaaaaa agaaaaaaac tttattactg acaattttaa cgataatcgg acttcttgta 3345181 ctcggaactg gcggctatgc atactactta tggcataaag cagcttcaac cgtggcaagt 3345241 attcatgaaa gcattgataa atctaaaaag agggataaag aggtcagtat caataaaaaa 3345301 gatccttttt ccgtcttaat catgggtgtg gatgaacgcg acggcgataa gggccgtgcc 3345361 gatacgctca tttatatgac cgttaaccca aaaacgaata caaccgacat ggtcagcatt 3345421 ccgcgtgaca cgtatacaaa aattatcgga aaaggcacaa tggataaaat caaccattca 3345481 tacgctttcg gcggcacaca gatgacggta gacactgttg agaacttcct cgatgttccg 3345541 gttgattatt ttgtgaaagt gaacatggaa agctttagag acgttgttga tacacttggc 3345601 ggcattacag ttaacagcac attcgcgttc agttatgacg gttattcgtt cggcaaagga 3345661 gaaatcacgc tgaacggaaa agaagcgctc gcttataccc ggatgagaaa agaagatccg 3345721 agaggcgact tcggacgcca ggaccgccag cgccaagtca tccaaggtat tattaataaa 3345781 ggcgctaata tttcttccat cacgaaattc ggagatatgt ttaaagttgt tgaaaataat 3345841 gtgaaaacga acttgacctt cgataacatg tgggatatcc agtccgatta caaaggtgcg 3345901 cggaaacata ttaaacagca cgaactaaaa ggtacaggca cgaaaatcaa tggaatttac 3345961 tactaccaag ctgatgaaag cgccctttcc gatattacaa aagagctgaa ggaaagcctc 3346021 gaaaagtaaa acaaaaagaa gcttcgcaca atgtgcaaag cttctttttt atttgcctgt 3346081 aaatgaatcc ggttgttctt ttcgataccc gtaatgaaac agcaattctt ccacaatccg 3346141 gcgggaagcc tctccatctc catacggatt agaagcctgg gacattttct tgtactcatc 3346201 aggatcagtt aacagctgtt ttgcaagctg ataaatgttt tcctcatccg tacctgcaag 3346261 tttcagcgtt cccgcttcca ctccttcagg ccgttccgtc gtatcacgca gaacaagaac 3346321 cggtttcccg agagatgggg cttcctcctg cacgccgccc gaatcggtca atataaaatg 3346381 cgatttcgct gcaaagttat ggaaatcgat cacctctaaa ggttcaatca gatgcactct 3346441 gtcagaatca ccaaaatgct tatgagccgc ttcccggaca acaggattca ggtgcacagg 3346501 gtaaacgact tgtacatctt caaattcccc tacaattctg cggatggcct taaacatgtt 3346561 ttccattggc tcacccaaat tttcccggcg gtgagcggtc aagagaatca ttttatcctc 3346621 acccacctga tcgagaacag gatgtgagta accatcccta accgttgtgt tgagtgcgtc 3346681 aatcgctgta ttgcccgtta caaaaataga gtcggccttt ttgttttctt ttaataaatt 3346741 gtctttcgcc tggcctgtcg gagcaaaatg caaatcagca atcgcccctg tcatctgtcg 3346801 attgagctct tccggaaacg gggaatactt attccctgta cggagccccg cctccacatg 3346861 accgacagca atttgatggt aaaaagcggc taggcttccg gcaaacgtcg tcgtcgtatc 3346921 accatggaca agcacaatat cgggtttgat atctttaaac aactcatcca atcttacaag 3346981 tgcgttagac gtaatctctg ccagtgtctg ccgctccttc ataatgttca aatcgaagtc 3347041 aggcttgatg tgaaacgcat ctaacacctg atcgagcatc tgtctgtgct gtgcagttac 3347101 cgttacatag gaatctattt caggatattt tttcaattca agcacaagcg gtgccatctt 3347161 gatcgcttca ggcctggtcc cgaaaacggt catcactttt agttttttca tatttgtcac 3347221 ctggttttct gctatagtaa ataaattcat actacatatt ctacatgaaa atgcatcatt 3347281 ttaaatcatt tcattcttga ttcaaataaa atgatataag ttttaatatt aaggataaag 3347341 cttgtttaaa aatggtttat ccgatatcat aaaaatgtgt aaaaacatat tgaaaagggt 3347401 aaatagagaa tagtttaacc ataaattttt tcgatcataa ggaaggtgcc ttttaaatga 3347461 aaaaagtacg taaagccata attccagcag caggcttagg aacacgtttt cttccggcta 3347521 cgaaagcaat gccgaaagaa atgcttccta tcgttgataa acctaccatt caatacataa 3347581 ttgaagaagc tgttgaagcc ggtattgaag atattattat cgtaacagga aaaagcaagc 3347641 gtgcgattga ggatcatttt gattactctc ctgagcttga aagaaaccta gaagaaaaag 3347701 gaaaaactga gctgcttgaa aaagtgaaaa aggcttctaa cctggctgac attcactata 3347761 tccgccaaaa agaacctaaa ggtctcggac atgctgtctg gtgcgcacgc aactttatcg 3347821 gcgatgagcc gtttgcggta ctgcttggtg acgatattgt tcaggctgaa actccagggt 3347881 tgcgccaatt aatggatgaa tatgaaaaaa cactttcttc tattatcggt gttcagcagg 3347941 tgcccgaaga agaaacacac cgctacggca ttattgaccc gctgacaagt gaaggccgcc 3348001 gttatcaggt gaaaaacttc gttgaaaaac cgcctaaagg cacagcacct tctaatcttg 3348061 ccatcttagg ccgttacgta ttcacgcctg agatcttcat gtatttagaa gagcagcagg 3348121 ttggcgccgg cggagaaatt cagctcacag acgccattca aaagctgaat gaaattcaaa 3348181 gagtgtttgc ttacgatttt gaaggcaagc gttatgatgt tggtgaaaag ctcggcttta 3348241 tcacaacaac tcttgaattt gcgatgcagg ataaagagct tcgcgatcag ctcgttccat 3348301 ttatggaagg tttactaaac aaagaagaaa tctaaacaaa aaggctattg gacattcatc 3348361 caatagcctt tttttatttc aacatcaaag tcaatgtatg ctcttcatta tcaactgcga 3348421 agacctgatc aacggcctgc cgcaaaaatt aataatccca gacaaacaca ctgattgtag 3348481 agttaaacaa actaaatgaa aacataaata caaacatgca gattaaatag taaatatctt 3348541 gtattcaatg caagctaagt aaacaccact tgctaaaaga acaatgacta aacaaccagc 3348601 attacaaaat aattaaataa atttgaagca attacaacag aaggcagtga actgtcggaa 3348661 agttcatttt ggctaccata ttaatccctt taactacgct gttggattta tcaagaattg 3348721 tcgggctaat agaaaaccac ggaatcaaac cagccagcat tcaaacgata aaaggcactt 3348781 ctccgatacc tgttatgacc agcttactgt tgcgcatccc aaatacaaac cagtacgcca 3348841 tcattagaat aaggggattt aaaacctgcc ataatacacc aaaataattg attttttgga 3348901 tctttcggtt aaagaaattt aaaagtacca gtgaatattg taacaaatgt tgagtttttt 3348961 tcacttttaa aaagtaaaga gaagtctcgc agaacttctc ccaacatttg aagtgtcaat 3349021 ataaaacaaa ccaacctcat ttagcaactt tattattatc taattccaaa atagcattat 3349081 aaatacgatt cctattattt ttatcagtat atgcaaaaaa gttatctact ctttttctat 3349141 acttatcttc catacgacta ttgtttttca tataatagat aactttatcc actaagctat 3349201 tatgattttc taatacatca ccaaacccca tttttttata atcataataa tcaagtttaa 3349261 aatggtatga cttttcgtat tgataataaa taacaggttt tttctcatat gcaaaatcaa 3349321 acgcaacaga tgaaaaatca gtaatcatta tattagaaga attaaatagc atttgatagc 3349381 tgctgttata gtcggcaaac tccacataat catgcttttc aaagtctaca atctgttgct 3349441 gaatatctgg gtgaggaaaa aaagttattt tataattatt tttcttagca aattcgatta 3349501 gccgttcatc attaatcaaa gcattatacc tagaaaaata ttcactatct ttaaatttcg 3349561 ggttgtacgg tcttactcct tttgcctgat ctttcggtaa tacaatatct tttctccaag 3349621 tcggcattat tagaagttgc ttttctccct cactcttctt aagattatcg tatctcggaa 3349681 atccacccaa caaaatattc tcttttttat agttgtaatt ccctttcaca atagaccgat 3349741 attcaggttt ggcagaagtg actaataatt tgatattctt gttgtatttg tttaaccatt 3349801 cagaatgatc tgccattgtt attccgtgct gtaaaaagat aaactcaaag ttaaataaat 3349861 ctctaaaata aatctccata ttaaaaaatg gatttacaac ccatatatct gcatgtgtcg 3349921 atattacttt ggaagaggat aaggttaaaa ttttatgtct aaaagatctg tatggtatga 3349981 cctttccata ttttttgatt ctgtcgtaat ccttgctatc tttttttatt ataaagtatt 3350041 tttttacccc atcattcttg ttgattgcat atttaaagag gtgctcggca ttatcatcag 3350101 ctttgtcttg tctgtctatg aataaccata ctggttttct attaaaaata gtgaaaacat 3350161 ggtgtaccat tcttgccatc agtgccttct taatcgctga ttttcgtttt tttgattttt 3350221 cccctgattt atgtagggat tttaagaaac gaaactcttt tataaatcta tttttaaaat 3350281 tgtttttttt gaacattaat tttttataat tataataaaa aatataatct tttttagcca 3350341 cataagtatt atataaatcg tttgacaaac ctgaatactt gaaaaaacga agttttgtca 3350401 acttcctttt tttaccctta gttataaaaa actcaatatg atgattatct gctagatgac 3350461 ctttgggaat atctattgaa aaaccgggat atttttttat tacttctcct aaacttatat 3350521 aatcattatg ctgtcttttt atattctttg cttttatttt tgtttcgcca attttagcat 3350581 aaaacttaaa acctttagaa ttaaacagcg agctccaaaa gccttctatg tgaatggaat 3350641 cctcattttc ttctaaaatt tcaatagtta aagtttgatc cgataatttc gaaacaattt 3350701 taccttctct gtataaataa taatcctgtt cagtttctct ttcatataca tacctactat 3350761 aattttcacc gtgctttatt tttaaagcat gatataaata gaaatggctg acactttttg 3350821 tttcaatgat gacatcgtcg tcaatatacg acaatacttc tcgaatcaat gttaaaaatt 3350881 cactgtattc attttcgtct aaaggtgttt cactgatatc cttaatcaat aatttccact 3350941 tcaaatcatg cataaccata tattgaagaa ataaaggtat tttctgttca tgatttttta 3351001 taatatcgat taaattcttt gagaaagtga taagtgaatg gttaaaccaa ttcttatttg 3351061 ctttagcagt ctgcatggca gatgatccat cttctctaac tctataatgg tattttgcct 3351121 ctttaaccag accatacttt ttcttttgcg atatgattaa attaactagt ttggcatctt 3351181 cacctatttt acaattttca tcaaacctga tatttttcaa ggcatctttt tttataaatg 3351241 tagaacaaca atgagttaat atatgatgcg gttctttttc tacatccaaa attcttgtag 3351301 aagaaaactt attatttaga ttatgttctc cagttcttcc ttctgcaaaa aaaataggga 3351361 ttgctacaat atcaatttca ttcttatgtt cgtcaaagaa gtttaaaaca ttttcgaatg 3351421 ttccttctga aactaaatca tccggatcca aaaattgaat atatctacct tcagcatact 3351481 ttaaaccata atttcgagca ctgctcactc cgccattctg tttctttgca tagacaatgt 3351541 tattgggata tttctgagca tattctttac aaatgatttc acttttatcg gggctatcat 3351601 cattcaccag tattaactga atattctcaa aaccaatagt ttggttaatg atactttcta 3351661 tagcttcagt gagatacaac tcaacattat aaatcggcat tataacactg aaatcatagt 3351721 taaaactttt ttcgttcata aaagattact cctaacataa tgtttatatg aataagaatt 3351781 cgggtaaata aaattaagaa acaagagagt actaattttt gcaaaacaat tttaatttag 3351841 taaaatgtat gaaaagcatt ccttaccttt ttttaaaaac ccttgtaagc aaacttttaa 3351901 aaatgttcac atggttaagt tctaaagaat catttggtgt ttttagtaca aagtcaaatg 3351961 caaaggccca aatcggtatt tcgacaacaa aaccagcata tctaaaatct cttaatttat 3352021 atccccatac ttcaattgtt tttttcagtt cttttcgttt gcattttttt aatcttttaa 3352081 aatattttat atatattctg tcattttctt tcatctcata atactggtta ataaagtgcc 3352141 ctgttaattc aagtctaagc ccttttattt ttgccgaagt aacagtacat gaactatgca 3352201 gtactctttc tttttttata ttttcaagag cttctgtatt ttcttttaat aagtgaaaca 3352261 taaattcttt atagtacatc ggcatatctt gttcttttat aaattgcggg tcaataaatt 3352321 ttaaaacttt aataaaatca tcaacaaaaa ctctttgttc ttgttgatct aaaacagact 3352381 tataaacatc tctatagttc ggatataaaa acagttttat atgatataca attaaaaatt 3352441 gcaaataagg caaaactata tcatatttgt tgaatgaatc catcaacaaa gtcatgtaac 3352501 attcattcaa caaatatgtg tacctttttt tgttaaacca tgaacgatca actaaagaat 3352561 cctgttcttt ccgttttcta taaaaatact ttccttctgc aactgctccg tatctttttt 3352621 ctttcagtaa taactggtta aaaaagatag cgtcttccca aaactttata gattcatcaa 3352681 aaaggacggt actagttagt gtatgtcttc tgtaaaaagt gccgccaata taaaaatgaa 3352741 tagctttata atcgttgaga atatttataa ctcttgttcc tttttcaaat ctattattta 3352801 atttatgtcc cccttctttt tcacctgtgt aataaacagg taataccgca atatttacat 3352861 gttcggaatc acaaaaaaaa tcataaacac tttgcagcgc attttgagag aatgcatcgt 3352921 cagaatcaag aaaaccaata aatttagatc tttcgcttac atttgataat ccacaatttc 3352981 ttgcagcaga aggtccagag ttttcaattt tcatgatttt aatattatta ggatatagat 3353041 ttttaaagga ttcacaaatt tgaggactgc tgtcaacact accatcatct attaatatca 3353101 gttctatatt ttccttaaat ccaattgact ggttaaggac actctctatt gaatatctta 3353161 aataattttc agaattatat attggtataa ttatagaaaa catgtttgta cctctttatt 3353221 tagaagttaa aggatcgttt caattactct tttagaagcc ttgcctcttc taaattacaa 3353281 aatttattat aaaaatcctc atagttatga tctatataag gattatgtaa caactctttt 3353341 accgtatcta taagttcttc acttgtttga agcaagtttc ctggcgtttt ttgctgaaaa 3353401 ttaaagtaaa aacctctgat acagtctcta taagccggga gatcatacac aaaaaataca 3353461 aggttttttt aaaaattcat attatcaaaa aagacagaag aataatccat aatcaataaa 3353521 tcactaatta aatataaatc tcgaatatct ttatttaaag aaacatcgtt cacaaaatat 3353581 ttatatttcc ctaattaaat tgttctgaaa ctggataata ccattcttac aagaataacc 3353641 atagagtctc caaggttccc tcttcatttc ctctaatcaa attaaagtta aatttatact 3353701 ggccagcttt cttaaaattc attatcccgc aaagttggtg catataaaat tatttttctt 3353761 taattcctta tttgataatg tagaattggt aggggattgt agctaaactg tttccagaat 3353821 agctttcaaa taaaattaat ttattgtttc ttggcagaag gacaaaaatt ttaaacaaaa 3353881 ctgaataaac tctaactagt aaacttctgc aattggttat aataaaaatt tcatcagtga 3353941 actccttaaa gagtgaagat taatatttac gcaaacaaga aaaaaagaag caactgaatt 3354001 tacttcaagc ctcttttagt tagtgcttct ataaactagc catatctttt ctgatttggg 3354061 tagttgaaat gcctgctatt cttgtaaggt aaatggcctc atagtattcc tttgtagaca 3354121 atcgtacgat taagtaatcc caggttcttt tgctctttcc agtagcttca tatgtccata 3354181 gtgaaataaa tcaaacattc cgtacgtatc actttcttca ttagataaca tcaccttcca 3354241 accttttcca acttagaaaa aacaaaaatc cttaactgat tgtttatcat ttcgacatat 3354301 tttttacgtt ccattaataa taaacaataa tagcatatgt tcctataaaa gttaaggctc 3354361 tttaaaaatg taaatcatca gcactttttg acaatatcgt tgcattgatg tgtatttttt 3354421 acagatctga tatcttatct atactcatta caacaagttt tctattccgg aagagtcaat 3354481 tctttttgtc gcgttttcaa gtgtaatgat tttctttctg ctgcgtcatt tattttgtac 3354541 gccctcctca tattacttca tcgtcaaaac gtgaaggaat tgtaatacgt agttcctaaa 3354601 aattttcgtg gtaaaattta gtgaagtctt tatcaggcta agggacttta tctaaactac 3354661 gaattacata tggagatata tagatgaaaa ggagggttga tatgatataa acgaaaatca 3354721 attagataaa ggaaaaactg aacacttctg aaaaaagtga taagtttctt tcactatatc 3354781 ctccaaaaag aacctaaagg tcttggacat gctgtctggt tcgcgcctaa ctttatcggc 3354841 gatgagccgt ttgcgtttct gcttggagac gatattgttc aggctgacac accagggttg 3354901 cgccaattaa cggatgaata tgaaagaaca ctttcttcta ttatcggtgt tcagcaagtg 3354961 cctgaagatg aaacacactg ttatggcatc atcgccccgc tgacaagtga aggccgccgt 3355021 tatcaggtga aaaacttcat tgaaaaaccg cctaaagaca cagcaccttc taatcttgcc 3355081 atcttaggcc gttacgtatt cacgcctgag attttcatgt atttagagga gcagcaggtt 3355141 ggcgccggcg gagaaattca gcttacagac gccattcaaa aactgaatga aattcaaaga 3355201 gtgtttgctt acgattttga aggcaagcgt tatgatgttg gtgaaaagct cggcttcatc 3355261 acaacaactc ttgaatttgc gatgcaggat aaagagcttc gcgatcagct cgttccattt 3355321 atggaaggtt tactaaacaa agaagaaatc taaacaaaaa ggctattgga cattcatcca 3355381 atagcctttt tttatttcaa catcaaagtc agtgtatgct cttcattatc aactgcaaaa 3355441 acctgatcat ctgtattcac aagaaaacgc ttcttgctgc tgtcatacaa tacatcgcta 3355501 tcacttaagg atagtgacgc cgggttgata ggagaaatgt tatgaaaaat aagctctgtt 3355561 gctttatcat tctccagtac ataactgatt ttttcataat caaaattcag cgtttttctg 3355621 ccgtcagcct tatttccttc agtataacca ttcaatttcg attgaatgct ggtgctgctg 3355681 tctcctagga atttcagaaa gtattcatag gaagatgctg cgttttgcga gacataagac 3355741 gtaaatgcag tggcatgcaa ttcagcgtgt ttcatgttag ttgcaacagc gctctgtttc 3355801 acataataag agtgcccgtc aaactttatt ttcgctgctt gtttgccttt tgcagctacc 3355861 gttacttttg taccgaatgg cagtgtaacg tcagccttct gtttcaaacc ctgatcctta 3355921 taagcagccg ctttttcatt tgctataaac ccttgcttat tgattgcagt taagcgttcc 3355981 tctgacttgc cctttgcatc gccatgatgg ttcttcactt cattttgcgg aatagcgcca 3356041 aacgaagcaa ttgtacgaag cggggcatta aagaacatcg ttcccgccat gaagacagtc 3356101 agaatagaca aaatagcaat ttgaatggca ttggccagtg atttcggctt tttcttcttt 3356161 ttgcggaaac gggcaaacgc ttcaggatct tctttcttcc tctcttctgt ctgctctttt 3356221 ttatatgtct ctttttcttt tttcgatagc ttattaaacc agtcaataaa cgctttgtac 3356281 tctttcacaa ccgtttttgt ttcatcaaac atacgaagct cgccatagtg catccaagca 3356341 acacggtcac acatcttttc aatctgaccg attgagtggc tgacaaagaa aatcgttttt 3356401 ccttgctttt taaactcatt tattctgtct acacacttct gataaaacgt ttggtccccc 3356461 acagaaagag cttcgtcaat aattaaaatg tcaggatcaa tatgcacgga gatcgcgaaa 3356521 ccgagacgcg acttcatccc gctggaatag tttttaaccg gctgattaat aaaatcgcca 3356581 atctcggcaa attcaacgat gctgtcatac atatcatcaa tttctttatt ggttaacccc 3356641 atcatcaaac acttgagccg gacattgtcc cggcccgtta attggttatt caaaccggca 3356701 gcaatcgcaa tcagcgacgg ctggccgttc atttcaattt caccgctggt cggcggaata 3356761 attttagcca gcaggttaga catggtcgat tttcctgacc cgtttattcc tacaaagccg 3356821 attgtctccc cttcatacac gtcaaaggag acattccgca cagcaaaaaa accattatcc 3356881 ttagccggaa aaaacaatcc tttaatcttg tccgattgtt ttttatacaa atgatactgc 3356941 tttgaaacat ttcgaaacga aacttttagt ttcatcgtaa aatctcctta cgtattaaag 3357001 aaagtcaaca aacttgtctc tgaatttcat atgcaggata gaacctacta acaataaaag 3357061 gaatgtgaac aaccaaaagt acagcgtgta cttcatgtca tggaaaaacc atgctccatc 3357121 taagaagctg ttccggaatc cttcaataat atagaatagt ggattcaact tcagaacagg 3357181 cactaattcg gggtggcttt gaccgagttt cgcattaaca tcccaaaaaa ttggcaacaa 3357241 gaaaaacaaa agtcttgtta cggcctgcag caaaaattga taatctctaa tcagcacact 3357301 gatcgttgag ttaaacaaac taaacgaaaa cataaaagca atcatacaga tgaagtaata 3357361 aatatattgt aaccaatgca cactcgggaa cacaccatta actaggagta caatgatata 3357421 aatcaccatc atgatcatat aactaaataa gttagatgca attgccacgg acggtagaga 3357481 actaatcggg aagttcattt tagccaccat attaatgcgc ttaaatacac tatttgatcc 3357541 atcaagtata gttggactga tgaaaaacca tgggattaat cctgccagca tccaaataat 3357601 aaaaggcact tcgcccgctc cggttgtcac aggaccgccc tttctaatcc ccataccaaa 3357661 tacgaaccag taggccagca tttggataag cggatttaag aactgccata agacacctaa 3357721 ataattcatt tgatatttag acttggtttc ataagccgcc aatcttaaaa ttaaaggaaa 3357781 tgacgttatt tgctctctga gtatacgcaa caaatcattc attttttatc ttccttagac 3357841 ttaattgttt ttgggaatct ttctgtttaa aatttgaaag caccgctgat tattgtaaca 3357901 gatcctgcat tttttttcac ttctcaacaa gtatctaaaa agctgccgaa aaatcgacag 3357961 ctatacattt tataaaataa cctaaattat tcagctttaa atacagtatt aacaaccttt 3358021 tcagatgaac gtcctgactc taaatagcaa aacttatcat agaaaggacc aaaagaaacc 3358081 ggaagcttat aatcaggcga tgagatctgc ttgatagcct caatcgtttc ttcagtagtt 3358141 tttaccaaag gaccaggagc ttctttttca aaatcaaagt agaaaccacg caacttgtcc 3358201 cggtaggttt cgatgtcagg gacaaagaat agcattggcc gttttaaatt tgcaaaatca 3358261 aagaatactg aagaataatc agtaatcagc aaatcagaaa ccatatacaa ttctcgaata 3358321 tcctcataag cagaaaaatc atatgcaaat ccttcaaaag gacctaaatc aaaattctca 3358381 gctaccagat aatgcattct taagattaca atatattcat ttccaagttc ttgtctaagt 3358441 tgatgcaaat ctaaatcgag atcgaactta taacgccctt ttgcatagaa ctgatcatct 3358501 ctccatgtag gggcatataa aataaccttt ttatcacgag gaatatttaa cctactcttt 3358561 atcaatgata ttgtttcctc attattatca ttatgaagaa aatcatttct aggatatcca 3358621 gattcaatca ttgtcttgtt aaactgaaac gcccgtgtaa agatctcagt tgaataacca 3358681 tttggggaaa tcaagtaatc ccaattagaa gcttccttga taaaattcct tttatatttt 3358741 ttggtgtttg taccaggcat atggacttct tccatatcca ttgcaagtct ttttaaaggt 3358801 gtgccatgcc atgtttgtaa atatgttgta tgactaggtt tcggaatcca taatggaagc 3358861 cggctgttaa caacccaata ctcagctctt gccatagcga agagccattt taatgagagg 3358921 cgattaatgt aaggaattcc cttttcatca aaaggcgctg aatattgttt atttacactc 3358981 caatacattt tatactcagg gtggttttcc cgcatatatt cgtaaatcgc tctcggatta 3359041 caactgtatt gtttcccatt aaaactttca aaaatgactg ttttcctttt aactggcatt 3359101 ctgctagcca tcatgaatag agatttgtat gttttagtga ttaacttgtt tctcattttt 3359161 gtgatctttt ttatttttga tactaatctc ttcttctttc ctttaataaa gtatttcatc 3359221 cttgttttca ggctatagtc gtttactctg atacctagag tctgcttttt ctttttctta 3359281 aagacttcat aacgaactgg tgcgttgttt gttttaataa tacttactaa tccttttaat 3359341 ttgttttttc gatctcctaa aacaagagca gtgctgttga actgaatatc cgttccttca 3359401 tcgtcattgc atatatactc cataaaaaga cgataaacat aacgtttttc atttgagaaa 3359461 ggaatttctt tcaaaggcac tttcacttca aaatcataca gttccggaac aaaaccatct 3359521 gctctcatgt tttccaggcc atgtgttttt ctttctagct tgattggaaa tttttcctca 3359581 ataggtgttt ctccaccctt ttttaaaata aggttcaagt tttttatccg atattgattt 3359641 tcggaactca ggtaccccgc ataacctgtt atgcttattt cttcagagct aatctcgatt 3359701 tgatcaaatc tgatgatttt ggcctctctt ttcaccttaa tagaaaagtt gcctttatca 3359761 gttgtataag gtaaaatcaa aagttctgtg gtttgatcga catgaaaggc gcgctcaatt 3359821 gaatttactt cagcagaaag acgcttcaag agtggttcct gctccgcatc ttcatatttt 3359881 tttcgaaatt cgacataaaa atcatatgtt tgtcccattt caacaggcat aggcaaaaca 3359941 tgagcattta tctcagtttt atactctaat gagccagtgt tttgaagcgg aaattcagat 3360001 tccgttcctg aacgtctctc tttcagcttt aaaaataact ggtaatcctc taaaaattgg 3360061 tgttctgaat caattgagat taacaattca agacttccta aattgttttt caagcttttc 3360121 aaaatacatt taatcacagt gttttcaatc attacttttt tctgctcctc tgtataaaag 3360181 ctctttcctt tttgcttcct tttattagtg tcaactacta aggacattaa ctctctttta 3360241 tttccgtgac cctccaagag aaattgcctt taactgttgt atagggctct actctatagc 3360301 cattattagt atctatactg tttcctgaca attttgtttc ttcactcgaa agtcttcgca 3360361 ttgttttaat atggccattt gcattgaaaa caatataaaa atcaataact tgggttttat 3360421 tagcagctat cttttcaata tttacatctt tttcgagatc aattacaaac agttgatcat 3360481 tttgtaagtt tgttgaaata atttcagcct tattctttct gtccaagccc actaaacgta 3360541 tttttttaat atcattatga tcaaaattct caatgtcaat ttctatttta gttttatcaa 3360601 aatcctcagt ataggaacta atagaaggat ctttttttcc aaccttttta gagaacttct 3360661 ctctttctat tcgcacctca atcatctgat taagagcaaa agcccaattt tcaatatagt 3360721 tgggtcttga atatttttca gccattttaa aagcttgttc tgaaaatttt tgatgagtac 3360781 tttcatcttt catcaaagag ataatagctt gacccaattt ctctatatta tactgttcaa 3360841 tgacatatcc atttgctccg tcagtaacta agctccttgc tccgtaatca taatcgtatg 3360901 ttacaactgg acatccattg ctcagtgcct ccatatttga tagaccgaac ccttcaaaat 3360961 gagaggttga aatggttagc caagcttttt gaaactctga gtcagggtta tccgtatagc 3361021 ctttcaaaaa gacattgttc tgcagtttgg tatcttcaat ttcttttttt attttttcga 3361081 aatcttcacc cgatccgaat atatcaagtt ttgcttcagg aatttctttc acgactaaac 3361141 taaatgcttt tactgcatgt atcagatttt tcatagatgc aagtcttgaa ataatgacag 3361201 ctttgtattt ttcactcggc acattcaata cagcgggatc aagaggctta tcaattgtat 3361261 gcggagtaaa gaaaaacgtc tcttgttccc ctgaaatcaa tttaaaatct tctagctgct 3361321 cctcagttat aaaaaagaca gcatccaaat tatacatctg actaaatact tctttatagc 3361381 gacccttaat ttgatattta ttgctgccgt aatgcttgtt atgaataatt gctccataat 3361441 aggaagaagg tgattttttc actttaaaga catgtttgtc ttgcggtctg ctgtccacta 3361501 aaaacaactt aggtttatca ttttgttttt gcagatattc tatccaatat tgacgcagtt 3361561 ccgattcatc ttttactttt atctcaccct caagggagta ccaaataata tgagataatt 3361621 gaacatcttt ttcttcattg ttccatacat agagtttgtc taaatatact tgattttggt 3361681 cattaatata ttcctgcaga tacatcttgt ttagctgcac atcataatga gtaacgagaa 3361741 ctaagtttcc gttcttcgta tattcctctc tctttatgag ctggttttta tcattccaat 3361801 agtcgacgta ccggatagtt tctccatctc cgtagtaaac tacagacatt tcattgttct 3361861 tcttaccaaa caatctcaac agagtttttg caaatttccc cattccaact tgctttttta 3361921 tctggtcaag gcctatcctt tcttcgtatg atcttttccc atttgttcta acacttaaaa 3361981 aatcatcgaa tagattaata acacttgtga attttttatc aatcttaccg ttgctgtaca 3362041 attcatcaat ttttgaagac aactctaaat caaaacgaaa cgttaagaaa aaggtgtttt 3362101 ggttacactc ttctccaaat aattttgaac gcaataataa tgatttcgtc agaccgccat 3362161 aattacttgg cagtccacca gagataaaat aataatccat gtcaggaatt tgttttatat 3362221 tagattcact caccgcatgt aaagacaatt ttttactccc tttcggcatc tagaatatat 3362281 gatcattgaa atttatatct acccggatac tttagtcaca aaaatcaatg taagcatcaa 3362341 aaagtacttc ttatttcaat aagaagtact ttaattagat attgaaccaa tgatatcagg 3362401 atcctaaatt ataaaccagc aatttcctct ttgatctttg ttgtagagat gccttctgtt 3362461 cttgggaggt aaacaacctc acactgatct ttgagaaagt caaatttacc ttcccagtca 3362521 tcccccataa caaaaacatc aatattatga tcaataatat cttgcttttt ttgctcccaa 3362581 ttcttttcag gaattacttc gtccacatat cgaatggttt ctaaaattaa tttacggtgc 3362641 tcatagctgt gataagcttt tttttgcttt tgtaaattga attcatccgt tgaaatagca 3362701 acaactaaat aatcaccaag ctgctttgca cgctcaagca atttaatgtg accccaatgc 3362761 agtaaatcaa aagttccata tgtgataact tttttcattt aaagaaacgc tccttcctaa 3362821 tgttaaacac tattaaaaac actactgacg ttagcgatta aattctaaaa acctgtttgt 3362881 attccttata tcgacatatt tctcgtatgt cttcactgat cattaattat agcataccgc 3362941 ctaaaaaagg ttaagtactc atgaggagaa aaacattcca aaatatgtaa ttacactcag 3363001 actccattgg caccaaggtc tgttgttcat tcgttcattc aattgtaaaa ttggaaacat 3363061 atttaaattt aatgtaaaga taatgttaat cctttgttga agatttatgt taaaatataa 3363121 ggtagcttga ttttgctttt agaaactctc ggtttttaac tatataaata gaatcttaaa 3363181 ggaaggagga gccagacatg caaacagaga ctattcacaa tattccttat gttaacagta 3363241 acttaacatc atttatcgat tacctagaga aacattatat tgatcaaaag attggtgctg 3363301 tcatttccac agtcaaccct gaaattgcat ttgcagctat taaagatcgg gactactttg 3363361 atgtactatc ttcttcaaac ttcattttgc ctgatgggat cggtgtagtc atgatgtcac 3363421 gtttgactaa caacaggctt cagtcccgaa tcgcaggtta cgatgttttt aaagaacttc 3363481 tgggcgttgc taacaaaaag aaaaaacgca tatttctgta cggtgcgaag aaagatgtta 3363541 taaaaggtgt tgtatccaaa atttcttctg aatacccaaa cattaaaatc gcaggttatt 3363601 cagacggtta tgttcaagat cgcaccctag tggcaaaaca aattgcaaga gcaaatcctg 3363661 acatggtatt cgtagcttta gggtatcctc atcaagagaa attcattcat aactacagac 3363721 acttgttccc taaagccgta tctataggtc taggaggaag ctttgatgta tttagcggta 3363781 atgtcaaacg ggccccttcc tggatgatac gtttaaattt agaatggttc taccggttaa 3363841 tcttgaatcc atggcgatgg aaaagaatgc ttagcatccc aaaatatgct ttaacggttt 3363901 taaaagaaga aaaaaacaaa aaaactttct atccaaagcc tgaaaaagat catacaaaac 3363961 agatttaaaa acaaaacttt caaataaatg gatgataaaa atgaaaataa gatcactact 3364021 ggcgaattgc tatttgtatt ttttatcagc aatcgccttt tttctgcaat gggtgaaacc 3364081 tgaaagcaaa gtgaccctcc tgatctcatt cgaagcaaac gcaaaagcga ttcttgagga 3364141 atatgaacaa ggacaatact cttataaact taacatcctg tatacccagc aggcctctgc 3364201 tattgccgag agcttcccga atgtagatgc atatttatta caagaaaaaa accctatcca 3364261 tctcattaaa gctgtatacc taatgtttaa cagtaaagtg atcataacag ataattactt 3364321 tctattaaca agtgtgttaa ataagcggaa gcaaacgaaa tgtatccaag tatggcacgc 3364381 aaatggctca ctcaaaaaat ttggtttgga agacattaca aacatgcaac ggacgaaaac 3364441 tgatattaaa aggttccaaa aagtatacag ttcgtatgat tatttaactg ttggctcaga 3364501 agagatggca aatatcttca agaaatcatt tggaataaag gataaccaat tattaaaaat 3364561 aggtgtacct ttaacagacc cttattaccg agaaaacaag aaaaaaattt cagatactct 3364621 aaacatacaa agaaaaaaaa taatcctcta tgcaccgacg tttagagatt ataatatgca 3364681 atcaattcaa ttgcctttta cagaagaaca attaattcat cagttaaaag aagaatatgt 3364741 tttatttgtt aagctgcatc ccgccattca gaacaatatt gatattaaat attccagtga 3364801 ttatattaaa gatgtttcta actatgcctt gtttgatcta ctcatggctg cagacatatt 3364861 aatcactgac tattcttctg ttccctttga attttcgatt ttaaataaac ccattctttt 3364921 ttatacttac gatttaaaac tttatcaaca gaagcgggga ttggttgata attatctttc 3364981 cataatacct ggaagagcct gctatgacag tgaatcatta ataaatgaaa ttcaaacccc 3365041 atttaattat tccaaaataa aagttttttc cgatagatgg aataagtatt ctgatgggaa 3365101 ttcaagccaa aatttattga atttcatcga aaatttaata agctaaatga tgacacttgt 3365161 tcaaaacaga acaagtgttc ttttttctat tgaataccga acgtatgttt gctttaatgt 3365221 aattagttgc ttatggcagc aaataataat agaggtggta aatttatgag aaaaaaagaa 3365281 ctgtttgatt tcaccaacat cacgccaaaa ttatttactg aactacgtgt agcagacaaa 3365341 accgtacttc aatcattcaa tttcgatgag aaaaaccacc aaatttatac aacccaagtc 3365401 gcaagtggat taggaaaaga caacacccaa agctatcgca taactcgtct atctcttgaa 3365461 ggtttacaat tagacagcat gctgttgaaa catggaggtc atggtacaaa tattggaatt 3365521 gaaaaccgta atggcaccat ttatatttgg tctctatacg ataaaccaaa cgaaacagat 3365581 aaaagtgaat tagtttgttt cccatataaa gcaggcgcga ctttagatga aaattctaaa 3365641 gaacttcagc gattctcgaa tatgcctttc gatcataggg ttacacctgc tcttgatatg 3365701 aagaatagac agttggcaat tagacaatac gatacaaaaa ataataataa taaacagtgg 3365761 gtgacaatct ttaacctgga cgatgcaata gcaaataaaa acaatcctct ttatactatt 3365821 aacattcctg acgaacttca ttatttacaa ggtttctttt tagatgacgg ttatttatat 3365881 tggtatacag gagatacaaa cagcaaaagc tatccgaatc tcataactgt atttgattcc 3365941 gataataaaa tagtgctgca aaaagaaatt actgttggca aagacttgtc caccagatat 3366001 gagaataact tccgtgaacc ggaagggatc tgtatgtaca ccaatcctga aactggggca 3366061 aaatcattaa tggtgggaat tacaagtgga aaagaaggaa atcgtataag cagaatttat 3366121 gcataccatt cttatgaaaa cttcatgaat catgtaccta tgcttcgatc ccctttatta 3366181 aaaaccgtgg ggcaccaaga tacacctcca gaaagatttc aaccatttat tcaaaccttc 3366241 attttagagt ataatgctca aaacaaaaaa tggatggttc cgacttcagg ttatttacca 3366301 tcttacacat caaatttagt ccgaaatatt actatcaatg cagatggaaa cttgcaagtc 3366361 acattaaatg aacgctatat tagtttactg catcaatcga tagaaggaga tttccgctta 3366421 aaacaaaagg atatccgaat gggatcctgg tattttgccg gcggagaaaa atcaaatgtg 3366481 cttgaaatag gttttatgaa agggagtaca aaaatcagac ccgatgatgc agccatctca 3366541 aatgcttcaa gaatgagtat ttttatgatt gttgcggaca agattgaggt gtgataatca 3366601 aataggctgt agctatttaa tagctacagc ctatttgcaa ctttctaagt tttttatcga 3366661 tattccggaa catcaaaata aagtgtataa ccgtccagca atgaatacag gctgtacatg 3366721 cggtttactt gtttgtacgc ccagccgatg tctgttgcgt attgatgtgt cgctgtagct 3366781 gaccatctca ttttgtacag tgtgtcttga ttgtaagctg tgttgtggat atacgatgag 3366841 cctatgaatt tagctccgcc gataatggcc gcttctggtg tgaaccagcc ctgctcgtac 3366901 gcatatttgg ctccgtagta attcggattg ctgtcgtatg ctccaattcc atacatgttg 3366961 tatacggttt ttccgttata ggttaatcca ttggctaaag cggatgtccc gtttcctgtt 3367021 tccagaagag cgtgtgagat taaatacagt tcgttgatgc tatattgatt ggcggcatcg 3367081 ataaatgcct ttgctctccc tgtcaggatg cctttacccg caagcacttt ctgatttacc 3367141 tcagtaacgc tgagacccgc tgtctgtgac agcttgagaa attggaagta gtatttgctg 3367201 tctctggaaa agttattcgg atccacgtat tgaactactt catcactgct tgcgtttcgc 3367261 cagcccaaat tgatcttagc ccagccgttt atctgtccga tgactttcac tttatcgcct 3367321 tttttaaact ggccgatcac gtttgtcggg ctgacttccg gcgttgaccg gatatttagt 3367381 acatcagccg taacagttga tgttgctgta ttaatgtacg tgagcgatac gtaagccgct 3367441 ccgtctgttt gcggacttac tgtcatttgt ttttggacca tatcacgaag cgagagattg 3367501 tagtttgttt tcatgatttg cgggccgttt ttgatcttca cgatagatga tgtccatccg 3367561 tataattgtt ttagcttcgt tgatgccgca gcagctgtat cattgcctgt gaactgctca 3367621 tttacgctga ttttataaag cgtattgctt ttcgttgtat agctcggggt tacacttttc 3367681 gatttaagat aggttaaccc attgttcaat gcggttttgc tgctaagctg tgttgtcacg 3367741 attttgtatt gtgtatatgc agtctggcct gtttttgatg ttgtgactgc gatatgattt 3367801 tgtttgaaaa atgttaaaac gcggtcaatc tcttcttggc tgatgatagc ttcagttgtg 3367861 atttgatagc tgctcgcagc tgtctgaccg gttttctggc ttgctactga tatatgattc 3367921 gatttgaaaa acgtgagtgc ctgattgact ttcgtttgat caagcagaga ttcggttgtg 3367981 attttaaacg tgtcagctat ttgttttttg acggatttcg cagaagcact tagctgattt 3368041 ttctttaata tgttcaaacc ctttgtgact tttgcttgat ctgatgtttc ttctgagatg 3368101 agctgatatt gattttctgc tgttgatcca gctgctgttt ttgcagcttt tacttttttc 3368161 tgagcaaaga aggctgctgc tttgtttgct tgctgctcgc ctaaaatctt tgccgtcgtg 3368221 atttgataag ctgcagacgt tgtcgttttt ttgacgctgg atgacgtgta atgccatttt 3368281 ttctttttaa agaaagtgtc tattttttgg agctgctgtt ttgttatacc cttcatattc 3368341 acggtatatg atgtgctttt tccaacctgt tgataactgc cggatacgcc agtgtttttc 3368401 ttgatttggc tgatggcgtc ctttactgta ctcagccctt tgaaataagc tgattggaca 3368461 ttgtatgact caacggttgt tttttgattg atggacttgt agctgcctgt gatgccagtg 3368521 ctctgtttca gctgctgcaa tagagttttg gcattggctt cacctgaaat ggcggcagtt 3368581 gtgaacgtat aataggcttg ccctttcact gtttccttta atgatgcctg cagcccagat 3368641 tccttttgga aggcgttttt gatctgcgct gctctgctgt ctcccacgat tgtgccagac 3368701 tgaatggttg tgacagacac cgtgtgtgtg atgggctgat acgagctttt aatccccgtt 3368761 tgcttggcca ggctctggat aagcgccttg acttttgtct catcagcaat gtctgatgtc 3368821 atgacgttca tatagggctg agctgctccg taagctttta cagcgccagc cactcccgtc 3368881 tcctgtttca gctttgctag gatagtgttg gcctgttttt ctccggagat ggcacctgac 3368941 gagatggtga catatggctg tttgcttcca acaggacttg acgttcctgt aattgatgtc 3369001 tgtttggcga gtccgctcag tattgctttc gcttctgatt cgctatgaat gcctgaggcg 3369061 gaaatttggt aggtcgttgt tgtgcctgaa gcctgatagg atgcatccca gccagtatct 3369121 ttttccagtt tggcgacagc ttgtgaggct tggctttctg tactgaacgt attcgacggc 3369181 tctactttat atagtgagta gtcggtatac gcggctgcct gggcagaacc agacatggca 3369241 aaaaaggcaa gggacgcggc ggatagaagc ataggtgcga ttagtctctt tttcattcct 3369301 tctcctcttt cttattctat gagtatataa aactagttta tttatcggca cgcgcatgct 3369361 tcatttatag gtgaatcact tccattttct aataaaaaaa cttaacctcg aagtgagatt 3369421 aagtttaaat atgagacacg ataagggtac aagttccttt tatcgtaaaa tcgggcattt 3369481 gagccggcaa aataaagtga tcaccttttt tgagcggaca tgttttgtcc tcatacttga 3369541 gcaaaccgct tccttctatc acgctgcaaa tcagaaagga ttcatcctga gccatttcag 3369601 cttcgccatt gatgtcccat ttataaaccg aaaaatattc cccttggaca aatgttttaa 3369661 tggttattcc ttttcttgat tctgtcgatt catctatata cccgtccaca tggggaaccg 3369721 tggcggcatt gaccgctttg gcaaaatgaa gctctctcgg acttccgttg ctatcaagac 3369781 ggtcataatc gtacacccgg tatgtggcat ctgaattttg ctgagtctct aaaacaaggg 3369841 cccccttgca caatgcgtgc agcgttccgc tcggcacata atagaaatca cccggtttaa 3369901 ttttgattct tcgcagcagg ccctcccagt caccgctgtt gatcattgtg acaagttcgg 3369961 tttttgagcg ggccgtatgc ccgtaaatga tttctgcgtt ttccttacag tcgataatgt 3370021 accagcattc cgtcttgccg agttctccct cttcgttttc tccggcatag taatcatcag 3370081 ggtgaacttt aattgacgta tcttccttca catccagcag ctttgtcaga agcggaaacc 3370141 gatccccctc tacgccgccg aatacttcac ggtgctcttc ccaaagctcg atcaatgtct 3370201 ttcctttata cgggccattt gcaacagtgc tcggtccttt tggatgagcg gaaatggccc 3370261 agcattcccc cgttgattct gaaggaatac tgtatccaaa tctatctcgt aaagcggttc 3370321 cgccccagat tttttcttta aacacaggcg ttagaaaaat cggtgattgc gtcatgatcc 3370381 gtacccctcc cctgtaaata actgatcatc attttcccgg tgcgcccctc ttacaaacgc 3370441 ccgtataagc tgcctttttc ctatgacaac atatgtacaa agcatcatct tttcattacc 3370501 ccttcaaaga aaacgcttcc tatctattat atcacgtcga aaagaagctt tgtttcagcc 3370561 ttttcctcga taagaataat tctccttttt tgatacaaat taataaaaac cgtcaatatg 3370621 tttaagaagg agagaaacta tgcaaatcga ctctgatctc cagaacaatt tagacacact 3370681 gaaaaaaaca ttgggacaaa acgacgatat gatgttttat acatttgctt tcggagatag 3370741 cagacaaaag gcgtgtttac tgtatattga cggtctgaca gagaataaaa tgctggcgca 3370801 atacgtcatt tctcctttac aaaaagaggc gttggcccat aaggaatgct cgattgaaga 3370861 cttatccgcc ttttttttcg gctttcacca cagcgttgtt tctacaatga aagaaataga 3370921 gcagctcgtt ttttcagggc aagccatttt gctcgctgat ggctatcgcg gaggattagc 3370981 tttcgacaca aagtcagtcg caacacgcag tcttgatgaa ccctcctccg aagtcgtgga 3371041 acgcggccct aaaataggat ttattgaaaa gctgcggaca aacacggcgc ttttgcgtga 3371101 acggacgagt gatcctaatc tcgtcatcaa agaaatgaca ctcggaaaaa ggaccaaaaa 3371161 gaaaatcgct gtcgcttata ttcaggatat cgccccagat tatgtcgtca aagaagtgtt 3371221 taaaaggctg aaatcagtca atatagataa tttgccggaa tcggggacgc ttgaacagct 3371281 gattgaagac gaaccatttt caattttccc cacaatatta agcacagaac gaccggaccg 3371341 ggtcgaaagt tctctattag aagggcgagt gtccatatta gtggatggta cgccgtttgc 3371401 tttgattgta ccggctacgg ttgacgaatt tattcattcg cccgatgatt acagccagcg 3371461 ctggatccca atgtcacttg tacgccttct tcgttattcc agcatcctga tcaccattta 3371521 tttgcccggt ctgtatattt ctctcgtttc ttttcacacc gggctattgc cgactagaat 3371581 ggccatttcc attgcaggca gcaggcttaa cgtaccattc ccgccttttg tagaggcctt 3371641 tatcatgatc tttacgatcg aattgattcg agaagccgga ttaaggctgc ctaagccgat 3371701 tggacagaca attggcctta tcggcggcgt tgtcatcgga caggcagctg ttcaggcgca 3371761 aattgtcagt gcgcttatgg tcattgtcgt ttctgtcaca gcactggcat cctttaccgt 3371821 tccttcatac gcctataact ttccgctgcg gatcattcgg atcggggtta tgataagtgc 3371881 aacagcgctt ggcatgtacg gcgttataat ggtttatctg tttgtgatcg gccatctcat 3371941 gcgcctgaaa agctttggcc aggattacat tatcccgatc atggcgcagc ctggacagga 3372001 tttgaaagac acagtcatcc gtattcccac gatgttttta aaaagaagac cgacacgaaa 3372061 cgatcccgaa gataacatca gacaaaggtg atggctatga ggaaatcaga gcataaactg 3372121 acatttatgc agacgctcat tatgatcagc agcacattga ttggtgccgg ggtgctgacc 3372181 cttccccgct cagccgccga aaccggcagt ccgagcggat ggctaatgat actgctccag 3372241 ggcgttattt ttattatcat cgttctgctt tttttgcctt ttcttcaaaa aaacagcgga 3372301 aaaactcttt ttaagctcaa cagcattgta gctggaaaat tcatcggctt tctattgaat 3372361 ttatatatct gtctatattt cattgggatt gtttgctttc aagctcggat tttgggagag 3372421 gttgtcggat tctttttgtt gaaaaatacg ccaatggcag ttgtggtgtt tatatttctt 3372481 gcagttgcca tctatcatgt aggcggaggc gtttattcaa ttgcaaaagt atacgcttat 3372541 atttttccta taacccttat tatttttatg atgcttctga tgttcagctt tcgcttgttc 3372601 cagcttgatt ttatccggcc ggtatttgaa ggaggctatc aaagcttttt ctctttattc 3372661 ccaaaaacat tattatattt ctccggattt gaaatcattt tttacctggt cccctttatg 3372721 agagatccaa agcaagtgaa aaaggctgtt gctctgggca tcgcgacttc cacattgttc 3372781 tacagcatta ctttgctcat tgtgattggc tgtatgactg tggctgaggc aaaaacggtg 3372841 acatggccga ccatttccct tattcacgca ttagaggttc cgggtatttt tattgaacga 3372901 tttgatttgt tcttacagct gacctggaca gcccagcaat ttgcctgtat gctcggatcc 3372961 tttaaaggcg cccatatcgg gttaacggaa atctttcatc taaaaaataa aaacaatgca 3373021 tggctgctga ctgcaatgct ggctgcgacg tttttcataa cgatgtatcc caaggacttg 3373081 aatgacgtgt tttattacgg gacgcttctt ggatatgctt tcttaattgt gattacaatt 3373141 ccattcttcg tctggttttt aagctggata cagaaaaaaa tagggagggg gcagctgcaa 3373201 tgaaaacagc atcaaaattc tccgtcatgt tttttatgct gctggccctc tgcggctgct 3373261 gggatgtcaa agatatcgag caactatcct tcgccagagg gctggcgatc gatgagacaa 3373321 atgatcacca gtacaaactg acgtatcaaa atcttcttcc ccaaagcgaa gacagccaag 3373381 catccggaaa acccgaattt gttaatgtaa cgtcccacgg gaaaacgatt ctggaagcag 3373441 tcagtgatgt atccatcaag gaccctcctg tttatagcga tcatttaaaa gtgatccttc 3373501 tgggagaaaa actgatgagg aatcaaaatg tagaccaagt cctcaaccac tttatccggg 3373561 atgatgagct gcggcgaagc agctatttga tggcagccag agggaatgca gctgatgttt 3373621 tcacaaaagg aaaccccaat cagcagcagc cgatgccctc cgaaaaactg attgatttga 3373681 caactcacag cggatataac ggtaagatta tgataccgct gcgcatcgga agagcttctg 3373741 tctactctca gaacgggtac agttatctta ttcaagccgt gaaaaacgaa aagggaaaag 3373801 ccaagtatga cggagcaggc attatcaaaa ggggcagcaa taaactcgtt gggtttcttt 3373861 cagctgatga aacccaaaca ctgtcatggg tcatggggac gatccaaggc ggtgtcatgc 3373921 cgacgacaga taaaggacat ccgattacgt ttgaaattaa aaagtcgaaa acgaaaatta 3373981 agcccgtcat tgaaaacgga aagcctgtct ttcatatttc tgttaaaacg aagggcatcc 3374041 tgacagaaga ccaaaacccg aatgaaaact cctttagcaa aagttatttg cacaggctgg 3374101 aaaacatttt tgaaaaaaag cttgaacgag atgtaaagca ggtgatggat aaactgcagc 3374161 acgagtataa aaccgatccg gtctttttat cagaccacat aaggattcaa caccctgact 3374221 actggaataa agtaaaaggg cattgggatg aaatattttc tgagactgat tttaagtacg 3374281 atatttcttt taaaatcatt aactttggca cggtgggaaa gtaagcaatc aaaagggtgc 3374341 gcatgatcgc gcaccctttt ttatgttccg acagtctgct gttttccggc cgctcctccc 3374401 tgtccgtttt tgtcccgtaa atcctgctca atttcttcaa ggcttcttcc ctttgtctct 3374461 gtcactttaa atcggacaaa taagaacgcc atgataccga tcgcggcata aatcaggaat 3374521 aaataactga ttccgatcgc ttccattaat attggatagg ttaatgaaac aatcagtgtc 3374581 ccaacgtgca acattaaggt cgaaacaccg gtcccgattc ctctgacgtg aagcgggaac 3374641 aattcaggaa gcatcaccca cacaaccggt ccccagctga ccgcaaagac aacgataaac 3374701 acgcctaaac aaatgacggt cgtccatgag gcagccggag tgttatcgaa aaagagattt 3374761 actaaagcga gaacgatcaa gctgatcacc atgcccgcat tcccgaatag cagtaacggc 3374821 tttcttccaa tcttgtcgat gattttaatc gctactaatg tcatgagaac attgactgtg 3374881 ccgattccga ccgtgcctaa aatcgaagcg gagtttccga atccgacgtt tgtaaaggtc 3374941 tttggcgcat agtagatgat cgtattcgtt ccgataaatt gctgcaaaaa agcgagtccc 3375001 aaacctgcaa taagcgctgg gcgcacccat ggatcgaaca gctccttcag accgccttca 3375061 tcctgctttt ccgcttcttt tatatcatgt atttcctgat caatatcttt tgtgccacgc 3375121 aatttttcaa gaattttctt cgctttgctt tcttcgccat tcgtgaacag ccagcgcggg 3375181 ctctccggca taaacaaaat gccaataagc aagagcaatg acggcacagc agccaatcca 3375241 agcatccagc gccacgcttc ggcatcggca aatatgtaat tgacaatgta agaaagaagg 3375301 atgccgaccg tgatcatcag ctgattcagt gatgacagcg ccccgcgttt atgttttggc 3375361 gccagttcag ataaataaag gggtacgatt gtcgtcgatg ttccgactgc aagtcccaaa 3375421 atgatgcgaa acagcaccat gactcctgta tttggggcca gtgccacacc aagaccgcct 3375481 atacaaaaca gcagcgcggc tgccataatt gctttttttc ttccgaaacg gtcagtcagc 3375541 ttgccggccg ctcctgagcc caatatcgcc ccaaccagca aggagctgac aacaagacct 3375601 tctgtaaacg cgtttaagcc taactccttt ttcataaata aaatagctcc ggaaatcact 3375661 ccggtatcat agccatataa cgcgcctcca agagctccga aaaaataaag ccatatattt 3375721 gactgctttt tcataaagat gactcccttt ctccatcagc tgcaatgaca ttgtctgtgg 3375781 gattttttta gaaatctttt agcctctttt tccggccatt aaaccttttt atttttctga 3375841 tcataagttt tccaatcatt tacttgtatt tttttcaatg tcgccgaaac attttacctg 3375901 ctgcggcgtc caatataagg tgattcagta cattatcgtt atcaattttc aaaaacaaga 3375961 acttataaat ataggaatat ttatcgaaaa atgtctttcg agtagttgcc ccatggcaaa 3376021 tagaatggta cgcttcaaat attaaagaaa cgtgaggtat tgatatatgg aagaacgatc 3376081 acagcgcaga aagaaaaaaa gaaaactaaa aaaatgggtg aaagttgttg ccggattaat 3376141 ggctttttta gtcattgcgg caggctctgt cggcgcctat gcttttgtaa agctgaacaa 3376201 tgcttctaag gaagctcatg tcagccttgc acgcggagaa caatctgtaa aacggatcaa 3376261 agaatttgat cctggaaaag attctttttc tgtattgctc ttaggaattg atgccaggga 3376321 gaaaaacggc gagaccgtcg atcaggcaag aagtgacgcg aatgtgctgg ttacatttaa 3376381 tcggaaagaa aaaacagcta aaatgctgag cattccgcgt gacgcctatg taaacatccc 3376441 aggccacggg tatgataaat tcacacatgc tcacgcttac ggcggcgttg acttaactgt 3376501 gaaaacagtt gaagaaatgc tggatattcc agtcgattat gtcgtagaaa gcaatttcac 3376561 ggcttttgaa gacgtcgtaa acgagttaaa tggcgtcaaa gtaactgtaa aaagcgataa 3376621 agtcattcag caaatcaaaa aagatacaaa aggtaaagtc gttcttcaaa aaggaacaca 3376681 tacgcttgat ggggaagaag cgctcgctta cgtaagaaca cgtaaagcgg acagtgacct 3376741 tttacgcggg caaagacaaa tggaagtgct gagcgccatt atagataaat caaaatcatt 3376801 gagctcaatt ccggcttatg atgatattgt ggatacgatg gggcaaaatt taaaaatgaa 3376861 cttatctctt aaagatgcca tcggcctgtt cccgttcatc acttcattga aatcagttga 3376921 gtctattcag ctgacgggtt atgattatga acctgccgga gtctattatt tcaaattgaa 3376981 tcagcaaaag ctgcaggaag ttaaaaaaga gctgcaaaac gatttaggtg tataatgaac 3377041 gggatggcga ttacgccatc ccgttttaca tatttccttg ttgaaaatta tcaaagtaac 3377101 gtttagcctt aatttatatg gattatgttt cacaggcaag ctgaacatac tacacgaagc 3377161 agcttcattt ttaaggaggt tcccctacat atgaaatgta ttgcgattga tctagacgga 3377221 acattactga ataaagaaag cgtcatttct gcggaaaaca gagaggcgat caagcgggcc 3377281 gttgatgccg gcatcctcgt caccatttgc acgggaagag cgacatttga tgtaaaagcg 3377341 ctgctggatg acttggacat ccctatcatt gcagctaatg gcggtacgat ccacgacacg 3377401 ggttaccgtt tgatcagccg gacattaatg gatcaggaag ccggtaaagc gattgctgat 3377461 tacttacttt caaaaaacat ttactttgag gtatatacag atgaccatct gctttctcct 3377521 tttgacggcg aagctaagct gcacgcggag cttgacattc taaagagcgc aaacccaaac 3377581 gagcagacgg atgacttgtg gcaaggagcc atgactcaat tcaaacagtt tggcattaaa 3377641 ccaatccctc atatcgaatc ggtttttgac ggcggtgaaa acatttataa gcttctttgc 3377701 ttctcctttg atatggacaa gctgaaacaa gcgaaggaag aactgaagca tcataaaaaa 3377761 ctggcgcaaa cctcttcagg aaaacatatt atcgaaatcc tgccggcctc gtcaggaaaa 3377821 ggacgcgcgt taacaaagct ggctgacata tacggaattg aaacacagga tatctatgcg 3377881 atcggcgata gtccaaacga tttgtccatg tttgaagtcg ccggacaccg tatcgccatg 3377941 gaaaatgcga ttgatgaatt aaaagaaaaa agcacctttg tcacaaaaag caatgacgaa 3378001 aatggtgtgg cctactttat agaccagctt ctttcggggc aatatgcata aagaaaagac 3378061 tccagagatt ggagtctttt tcttttattg cacccgtata cttcctgcgt atttatcctt 3378121 ccaatatgtg ctcgtgttca tattggtaat ggtcacgccg tttgataatg tgacatgaac 3378181 aacttgtccg tttccgatat agatggaggg atttaagctt gttgattgaa agaacacaat 3378241 gtctcccggc ttcaggtccg ccttctcaat cttagttccg gcattgtact ggcttgttgc 3378301 gtatcgaggc agggaaatac cggctgcttt ctggtataca tattggacaa atccagctgt 3378361 atcaaatccc gtctcaggtg ttactccgcc ctgtttgtaa ggcacttctc cgacataaag 3378421 cgtcgcttcg gaaacaatcg gattttcttt cgggattgtc aggttgtcaa atcggcgaat 3378481 acccgtcatc ttcgatttcc agtaatcctc tgacaaatag gaaatggtta ctttttctga 3378541 ccggcttgcc tgaatgaacc tgcctgcgcc cgcataaatg cctgcatgtg aaattcccgt 3378601 tttatacgta ttgctgaaat agacgacatc accaggcttt atgttctgag gggctacctt 3378661 ctcgcccact gcccactgct gttcggctga tcgcggtaga taaatgccga gtgcctgttg 3378721 aaacacatat tgcacaagcc ccgagcaatc aaagccctct gacggcgtgc ttccgccaaa 3378781 cacatatggg acaccgatat atttttcggc ctcctgaacg acaggaacat cagccgttgc 3378841 cggatcggca gcgattcgtc tcgccccgat ataagttccg ctccaatagc tgcttttttt 3378901 gtaattggtg atgataaccc cttttgactg tgtactgtga accatttggc cgtctccgat 3378961 ataaagggcg tcatgtgtcg gaacagtgcc ggtgcttccc tctttcttga aaaacaaaat 3379021 atcacccggc ttcaggtttt ccggttttac agctgttccg attttatact ggtcgtttac 3379081 agatctcggc agatgaatat cagccttact gaacacatat tgtatcaatc ctgatggatc 3379141 gaaaccctct ttcggcgttt ccccgccata tttatactga tatccaagca ggttttttgc 3379201 ttcgctgaca atcaattctg atgatgtatc agcttccgca atctccgctt ttgtcataat 3379261 tggaaccaaa aaacaaatga taaccgccac aagcaaaaac ttcttccagt ttgccagtgt 3379321 gttcactttt attatctcct cctctttttg cagttttaac atcggtattt ttttgaatat 3379381 gttaagagac tttttaatat ttttacagaa tgaatatgct gggcaaataa aaagagagtg 3379441 tctcatcaga cactctcttt tttgaattat ttattggcgt ttaccggttc ttcctgctgc 3379501 tggattttat tcatttccat atcaatcttc tgtttttcct gatctgtcag ctgatcattg 3379561 aatttaaaag ctgacataaa catgaacacg atggctacgg caacaaacgg ccagatggct 3379621 ttgacaaatt tcatctttat cactccgatt atttagattt tagtttgtca ctatgatcaa 3379681 tatcaaacgt cagttttccg tcttctactt tccaagcgaa attagagtct ttcgtcagtt 3379741 cgcgaataat ggttttctgt ttaaggctgt cttttttcac aggcgcaggt gtcgcttcat 3379801 ggatatcgat cggtgtcact tcaaagcgtc ctgttccatt tttcttcagg tgatactgaa 3379861 ccagtgcact gtctcttgtt ctcgtccagc cttggtcaaa gacaaagttg ccgaggctgt 3379921 agaaaatgac ggttccgtta tatacttcaa tcggttctaa gacgtgcggg tgatggccga 3379981 cgatgatgtc agctcccgca tcagacatgg ctcttgcaag ctggcgctgg cggtcatttg 3380041 gatcattgtc atactcttgt ccccagtgtg actgcacaac aacaatgtcc gcatgttttt 3380101 tcgcttctga aatcataggg atgaagattt caggatctgc gggcagcacg cccggcgtat 3380161 tctttttagc cgcgaaacct ttcccggaca catcggtaaa gccaagcgtc gcaatcgtta 3380221 ccccgttgac tttctggtac gaaattttct ttttcgcatc acttaagctg tatcccgctc 3380281 caacgatatc aagattttgc ttcgcaaatt ctccaagcgt atctttcatg ccctgaacgc 3380341 cgtaatccat tgcgtggttg ttggcgctgt tgagaaccgt gaaattcata tccttcaaga 3380401 ctttcactga ttccttattc gtctgcagat gaatctcttt atctgcttgt ttataattct 3380461 tttgataggt taccgggttt tcaaagtttc ctgctacata atccgaggct ctaaagatcg 3380521 gttcaacata ttgaaaaata ctgtctgccc ctttttgctc cgttactttt tcaacatagc 3380581 gtcccatcat aatatcgcct acaaatgagg ctgagagtac gtcgtcagaa tacgttttga 3380641 ccttcggcgt ttccgctttt cccgcccaca tgaaagcgaa cataaggaca aaaacgatcg 3380701 gaatggcaat aaatacgtgc ttattggttt tctttttttg ctgttttgtc agctttagca 3380761 gcttttcatg aaagctcagt tcttttttca tcgtttgaca caccttacat taaattaagt 3380821 agtaaacaaa catgatagca aaggtcgctc cgctcaatag cagcgtgctt ccgaacgtaa 3380881 tggttaaacc ttgtttctga atggtattgg caattaaacc tggcacgatg atgccgattc 3380941 ctcgaaattc tgcgatttca aatggtacaa tcgggtatag aaaatcaaac gcgattttta 3381001 ggacgatccc tgttatcagc atggcagcga attttctgcg tccgtacaaa atcataaatt 3381061 tggataaacc gtatttcaca atgacatacg tgagcaagct cactagcaaa acaagtaaaa 3381121 taaagaccgg ctgattaaac acaagtccta aatatcccgg tacaacaagt cctgccggca 3381181 cgatccctgt tttttccgca aaaattaaac tgagtagtac acctaaaatt agtgcgatgt 3381241 ataaatctga tccgaacatg tctgcatttc cccctagctt acgagctgct ttaccttgta 3381301 ttcgtggatt ttttcaatta aaggctctgc ggcaccatga atattgccga cgccatatat 3381361 gacacggttg tgcattcttt tctttaacaa ttccataatt tcatctgttg acttatactc 3381421 tagatcatgc agtttgtctg caggaatttt gccttcttcg taggctttta cgatcggttc 3381481 tgttgtttca ccgattaaga tcagttcact tgcttcaata taaggcaata cgtcatttgc 3381541 gaattgctgt gtccgatcga cacggtctgc gcggcagttc atgatgatga tcggatcatc 3381601 ggtcgggtaa ccgatttctt ttacacgttt ccatatattc aaagtagaag aagcgtcgtt 3381661 tgcggcaaac ccattaacaa agtgcccagg ctcgctcgga ctgatcagcg gaagaattct 3381721 cattgctccc ggatctggcg gcgcattcag cattccctta aatgctgttt cttcgtcaat 3381781 gccgagtgct tgagccacac ccagcgccag agaagcgtta tcagggaata ccatgtattc 3381841 aaatttacgt aaatactcat ctgtaatttt tgagttatca gcaatgatga cttttgtgtt 3381901 tcgttctttt gctttttgtt taaagaactc ggtatattca ctatctgtaa tgacaagatg 3381961 gccattataa ggaattgtag cagtaaacgc ttctgcaatt tcatcaagcg tcggccccat 3382021 gacatccata tggtcttcca aaacattcac aatgacgccg atattggcct gcagaagttc 3382081 ttcctgaaag atgatttgat aatctgggtt aacagccatg cattcactga caatcgcgtt 3382141 agcccctctt tctactgttt ctctcatgac ttctttttgc tctccgatat tcggcccctg 3382201 aggtttccgt ttaatcggct tttcctccgg tgtgtcccag taaatcattc ttgcatctgt 3382261 tcctgttgtt tttccaacag tcttgtaacc ggcttctatt aatattccgg ttgtcagcct 3382321 tgtcacagtc gattttccgc ggatgccgtt aatattcacc cgaacaggga gggcatcaat 3382381 gtttttctga tgtcgtcgtt tttctaatat tccgatgacc agtatgacag cacaggctat 3382441 aatgagtaac cacattgctt ttcgacatct ccttctatat tgttgtaaat tcattcatca 3382501 gtatatagaa tcactatgaa ttctcaatcg gcattatgta acataatctt ccctaatcga 3382561 ctaagccaaa cttctctttt gaaagagatt ttatacctac aaactgtttt ctatttttgg 3382621 aaaacagcag gacttatacc ttatcacttt ttaaaaaaat caaagagaat gcgctttcat 3382681 ttttctcctg atatccttct ggacgtatag tcacaccctg ctgtttgtat ttaatatgca 3382741 tttcaaatca atcttttttt cagcctttgt tatcaagcat ttcctgctat catgcgtgtt 3382801 tccggttctt atgaacacaa aataatttta tcctgtttct taaggacaag gtcataatgt 3382861 catcctttct gcatggaata agcaatatga ggcccattcc aaaatgacta aggaggttcg 3382921 agatgaaaac gctaaacata cgagtccgaa ttctctaaca taattaaaca ttttctggga 3382981 tgatagtctt ttctgtttct ccccatttac aggtctaaac gcatgacttt gaaacaattt 3383041 taataaaact taatatttgt tcaagaaatc ttcatccata tttgtgaaga ctttgtcaaa 3383101 aaaagagtga aaaccttaaa tttttcaatt atatatacaa tttacaatta gatttctttt 3383161 gatattttta ttgctaactt cggattgttc atgataatct atctatgtaa acggttacat 3383221 aaacaaggag gagctgtttt ggctacaatt aaagatgtcg ccggagcggc gggcgtttca 3383281 gttgcgacgg tttcccgcaa cctgaatgat aacggctatg tacacgaaga aacgcgaacg 3383341 cgtgtcatag cggcgatggc gaagctgaac tattacccga atgaagtcgc cagatctcta 3383401 tataaaagag aatcccgact gatcggactt ttgctcccgg atatcacaaa ccctttcttc 3383461 ccccagcttg cccgcggtgc ggaggatgaa ttgaaccggg aaggctatcg ccttattttc 3383521 ggcaacagtg acgaggaatt gaaaaaagaa cttgaatacc ttcaaacctt taagcaaaat 3383581 catgtcgcag gcattattgc cgcaacgaat tacccggatc tcgaggaata cagcggcatg 3383641 aattatccag ttgtttttct ggacagaacg cttgaagggg ctccttctgt gtccagtgac 3383701 ggctatacag gagtaaagtt agccgcccag gctatcattc acggaaaaag ccagcgcatt 3383761 acgctcttga gaggacccgc tcacctgccg accgctcaag accgatttaa cggcgctttg 3383821 gaaatcttaa agcaggctga agttgatttt caggtcattg agacagcttc attttcaatt 3383881 aaagatgcac aatcgatggc gaaggagctg tttgcctctt atccagcgac agatggtgtg 3383941 atcgcgagta atgatattca agccgctgcc gttttacatg aagcattgcg gcgcggaaaa 3384001 aacgtgccgg aggacattca aattatcggc tatgatgaca ttccgcaaag cggacttctg 3384061 ttcccgccac tttctacaat taaacagccc gcatatgata tggggaaaga agctgccaaa 3384121 ctgcttttgg gtatcattaa aaaacagccg ctggcagaaa cggcaattca aatgcctgtc 3384181 acctatatag gaagaaagac gacaagaaag gaagattaag atgcgtaata tttgtgtgat 3384241 tggtagctgt tctatggatt tagtggtcac ctcggacaaa cgcccaaaag ccggtgaaac 3384301 ggttcttggc acgtcatttc agactgtgcc gggcggcaaa ggagcaaatc aggccgttgc 3384361 cgcagccaga cttggggcgc aagtgtttat ggtcggcaaa gttggagacg atcattatgg 3384421 aacagctatt ttgaataatc tcaaagctaa cggcgttcgc actgattata tggaaccggt 3384481 tacacatacg gaaagcggaa ccgctcatat tgtgcttgct gaaggcgaca acagcattgt 3384541 cgttgtcaaa ggcgcgaacg atgacatcac cccagcgtat gcgttaaacg cgctcgaaca 3384601 gattgaaaag gtcgatatgg tgctgattca gcaggaaatc ccagaagaaa cggttgatga 3384661 ggtgtgcaaa tactgccatt ctcacgatat cccgatcata ctaaacccag caccggcccg 3384721 cccgctcaag caggaaacaa ttgatcacgc tacctatctg acgccgaatg aacacgaggc 3384781 ttcgatttta ttccctgagc ttaccatttc cgaagctctg gcgctttatc cggcaaagct 3384841 ctttattacg gaaggaaaac aaggcgtccg ctattcggct ggcagcaaag aggtgctcat 3384901 cccgtccttc cctgtagaac ccgttgatac aaccggagcc ggtgatacgt ttaacgcagc 3384961 atttgccgtg gccctggctg agggaaaaga cattgaagcc gcattgcggt ttgccaatcg 3385021 tgccgcttcc ctttctgtct gctccttcgg tgcccaaggc ggaatgccga caagaaatga 3385081 agtagaggag ctgctgtcat gaaaaaacac ggtatactga acagccatct tgccaagatt 3385141 ttagccgacc ttggccacac tgataaaatt gtcatcgcgg atgccggact gccggttcct 3385201 gacggcgttt tgaaaattga tctttcactg aagccgggcc ttccggcttt ccaagataca 3385261 gcggcagtac tggctgagga aatggcggtc gaaaaagtca ttgctgcagc tgaaataaaa 3385321 gcatccaatc aggagaatgc gaaatttcta gaaaatcttt tctctgaaca agagattgaa 3385381 tacctttctc acgaggagtt taagctgctg acaaaagatg caaaggcagt cataagaaca 3385441 ggagaattca caccatatgc caactgcatc ctgcaggcag gtgtactttt ctagaaagga 3385501 agatgaaaca tgcagattga aatgaaagac attcataaaa cattcggaaa aaatcaggtg 3385561 ctgtcaggcg tttcctttca gctcatgcct ggcgaggttc acgcattaat gggagaaaac 3385621 ggcgccggca agtccacgct tatgaacatt ttgacaggcc tgcacaaagc agataaaggt 3385681 caaatcagca taaacggaaa cgaaacgtat ttttccaatc cgaaagaagc ggaacagcat 3385741 ggaatagcct ttatccatca ggaattgaat atctggccgg aaatgaccgt tcttgagaat 3385801 ctatttatcg gtaaagagat atcctccaag ctgggcgttt tacaaacaag aaaaatgaaa 3385861 gcgctagcaa aagagcaatt tgacaaactt tccgtctctc tttctcttga tcaagaagcc 3385921 ggcgaatgtt ccgtcggaca gcagcaaatg atcgaaattg caaaagcgct tatgacaaat 3385981 gccgaggtaa tcattatgga tgaaccgacc gcagcgttga ctgaacgtga aatcagcaag 3386041 ctctttgagg tcattacagc gttaaaaaag aacggcgtct ccattgtcta tatttcgcat 3386101 cgcatggaag aaatttttgc gatttgcgac agaattacca tcatgcgtga cggaaaaacg 3386161 gtagatacaa caaacatctc agaaactgat tttgatgaag tcgtcaaaaa aatggtcgga 3386221 cgggagctga ctgaacgata tccaaaacgc actccttctc tcggtgacaa agtattcgag 3386281 gtgaaaaatg cttccgtaaa agggagtttt gaggacgtca gcttttatgt gcgttccggt 3386341 gagatcgtcg gtgtttcagg attaatggga gccggccgga cagaaatgat gagagcgctg 3386401 ttcggcgttg acaggctgga cacgggtgag atatggatcg ctgggaaaaa aacggctatt 3386461 aagaacccgc aggaagccgt gaaaaaaggt ctcggcttta ttacagagaa tcgcaaggat 3386521 gaagggctcc tgctcgacac ctcgatccgc gaaaatattg ccctgcccaa tctgtccagc 3386581 ttctcaccaa agggtctcat tgatcataag cgggaggctg aatttgtcga tctgttaatc 3386641 aagcgcctca ctatcaaaac agcatcaccg gaaacgcacg cacgccattt atcaggagga 3386701 aaccagcaaa aagtggtgat agccaagtgg atcggcatcg gaccgaaagt gcttatcttg 3386761 gatgagccaa ccagaggtgt ggatgttggc gccaaacgag agatttatac gctgatgaat 3386821 gagctgaccg aacgcggtgt cgctatcatc atggtgtcat cagagcttcc tgaaattctg 3386881 ggaatgagcg atcggattat cgttgtccat gaaggcagaa tcagcggcga aatccatgcg 3386941 cgagaagcaa cacaagaacg aattatgaca cttgccacgg gagggcggta atatgaaaac 3387001 ggaacaactg caaacagaac aaaaacggat tcacttcgac ggagtcatgc aaaaactcgg 3387061 cccgtttctt ggtttattta ttctcgttat cattgtatct attttaaatc ccagctttct 3387121 tgaaccgctg aatattttaa acctgcttcg ccaggtcgcc attaacggat taatcgcgtt 3387181 cgggatgacc tttgttattt tgacaggcgg cattgatctt tctgttggcg ctattcttgc 3387241 cctgtccagt gctttagttg cggggatgat tgtgtccggt gtcgatccgg ttctcgcgat 3387301 catccttggc tgtatcattg gtgccgtact aggcatgatc aacggattat tgattactaa 3387361 aggaaaaatg gcgcccttta tcgccacgct tgcgaccatg actgtgtttc gcggactgac 3387421 gctagtgtat acagatggaa atccgattac cggacttggc acaaactacg gttttcagat 3387481 gttcggacgc ggttactttt taggcattcc tgtaccggca attacgatgg ttcttgcctt 3387541 tgtcatcctt tgggtgcttc ttcataaaac accattcgga cgccgaacgt acgctatcgg 3387601 cggcaacgaa aaagccgcgc tcatttcagg catcaaagtg acgcgcgtga aagtgatgat 3387661 ctattcttta gccgggcttt tatccgctct tgcaggtgcc atattgactt cccgcctgca 3387721 ttcggcccag ccgactgcgg gagaatcgta cgaacttgat gctatcgcgg cagtcgtctt 3387781 aggagggaca agtctttccg gcggccgagg acgcattgtc ggcacgttaa tcggggtgct 3387841 gatcatcggc acacttaata acggacttaa tctgcttggc gtctcatcat tttatcagct 3387901 ggttgtcaaa gggattgtta tcttaattgc ggtattgtta gaccgcaaga agtcagctta 3387961 ggagggtttt acatgaaaaa ggctgtatcc gtcattttaa cgttatcatt atttttgtta 3388021 accgcctgtt cgcttgagcc tccccaatgg gcaaagccat caaactcggg gaacaaaaag 3388081 gaattcacca ttggcttgtc cgtctcaacg cttaataatc ctttttttgt ctcattaaaa 3388141 aagggtatcg aaaaagaagc taaaaaacgg ggaatgaaag tcatcattgt tgatgcacaa 3388201 aatgattcat cgaaacagac gagtgacgtg gaagatttaa ttcagcaagg tgttgatgca 3388261 ttattaatca acccgactga ttcttcggcg atctcaacgg cagtagaatc tgcaaacgca 3388321 gtcggtgtgc ccgtcgtaac aatcgatcga tctgcggaac aaggaaaagt tgaaaccctc 3388381 gttgcttccg ataatgtaaa aggcggtgaa atggccgcgg cgtttattgc cgacaaactt 3388441 ggaaaaggag caaaggtggc agagcttgaa ggcgtccccg gcgcatctgc cacacgggaa 3388501 cgcggctcag gattccataa catcgcagac caaaagctcc aagttgtcac aaaacaatca 3388561 gctgactttg accgcacgaa aggcctgact gtcatggaaa acctgctgca gggacatcct 3388621 gatatccaag ctgtttttgc tcacaacgat gaaatggcgc tcggtgctct cgaggcaatt 3388681 aacagctcgg ggaaagacat attggtgatc ggttttgacg gcaataaaga tgcgctcgct 3388741 tccattaaag acagaaagct gtcagccacc gtcgctcagc agcctgaatt aatcggtaaa 3388801 ttggctacag aagcagcaga tgatattttg cacgggaaaa aagtgcaaaa aacaatatcc 3388861 gcgcctctca aactagaaac acaaaaataa ttgtctgatg tttaggaacc tgcgataacg 3388921 tgaatagaga tatagaatga attatttctc ttacgtgagg agaggaacgg catgaacaaa 3388981 ccaacaaaac tattttcaac attagcactt gcggctggaa tgactgcggc ggctgctggc 3389041 ggcgctggca cgatccatgc tcaacagcca gaaacaacgg taagcattga tgatttatac 3389101 agttatccga ttgattctta tttggtatca gcagaggctc taaatgtcag aacgaagcct 3389161 tccgcatcaa gccagaaagc cgatacgctg cacttaggag atagcctaaa gctgatttcc 3389221 ttctcaaatg ctgactgggc aaaggttaag tataaaaatg gaaaaacagg atttgtatcc 3389281 actcattaca ttgttaaagc agcgacaacg gtaaaaacca aaacaaaaac aaaagtgtat 3389341 acatccgctg acggaaagag cattaagact cttccagcag acacaagcgt ttctttttta 3389401 ggctggagta aaacgaataa aggcggtttt gattttgatt gggtattcgt tgattacggc 3389461 ggtacgacag gttatatgaa aacaaaggat ttacacatga caaaataact gagagggatt 3389521 ccgcataaat gcggaatccc ttttattatg aattgatttg tcacattccc aagatatttc 3389581 tcaggaaata ttgtcgtatg ctgtgtcgaa accttacatg atcatcgaca tttttgttca 3389641 cgctaaaaag cggaggtgta aatatggatc aatttgaagc agcatatgaa tcgtataaag 3389701 cccggcaaac aactgccgat caagaaaatg ttccatctgg aaaagaagaa attattgcgg 3389761 ttagaagaaa tgaggaagac aatattatcg cagtgaaaac caatacagga agagagctcg 3389821 actaccctac tgcgctgtca gaagcaaaat caggaaaact cgctcatgtt gatgtcttcc 3389881 ataaatacgg gcgtgacatt ttgcgaagtg aaccggacgg catcaaggaa aataacctgt 3389941 ctgagctgcc ggatttttaa acaaatacag ccctgccgta tgttggacag ggctgtattt 3390001 taaacaaaag gctgctggat gtattcggct aaccgttttg cactgtgaga aatatcctct 3390061 gcagctgcat aattcacgcc atagaacaca tatggaggca gatacttcat gccgatcaga 3390121 ttactcgtgg cctgaaatgg tttcaatagc tcactgatcg agtaatgatt tgctccgccc 3390181 gcttgatatt tttccgcttc gctccctgtt gatacagcca gcatcagctc cttgccatgc 3390241 aaggcatttc cttctgaacc aaaagcccag ccataagtca gcacaagatc ctgccatttt 3390301 ttcaagagcg gcggagagct gtaccaatat agcgggaatt gaaagacaat ccgatcgtat 3390361 tcctcgcaca gctgctgttc cttcgcaaca tctatcgctt catccgggta ttccttataa 3390421 agatcccgta ctgtgatatt gtcatgttta ctcaattcct cagcccacgc cttattaaca 3390481 actgaggtct ccatatgagg atgcactgcc aaaaccaata ttttcatcag accacacctt 3390541 tactgttttg atgttatttt atctaaaatc aggaaaagag ccaaataaaa agaaagccct 3390601 gctaaaaggg gctttctttt tttcttttat tcagggcttc cttcagttgt ttcgatatct 3390661 ttcgcaaaat cagggttatc cagattcgca ttaaagaaat ccgctgtgtt cggaagtctg 3390721 agattcatgt tcattttttg agaaatcgta accgtgcaat cctcaagcac atagtcaaaa 3390781 acgtgtccgc ctgaattgcg tccttcgtca atgaagtgca ggtgatagcc agaaacggcg 3390841 attccgtttg cataagctgg tgtcaagaaa cctacaatcg ttcctctcac gttgtcgaag 3390901 ttgaaaatcg gctgtgtttt gaccgcttca accattggca cgtaaggttt ttcttgaagt 3390961 tctactgttc ttgtctgcac ctttttaaac aatccgtcaa tgcgaattgc ataaaataag 3391021 tttctgcttg gcagcatgct gttgatctct ttttcaaagt cttcgcgtgt cattttcgca 3391081 tcaattttgt gcgtcatgtc cggtgtaaag aacgtaaatg aacagaacgg tgaacggtct 3391141 ccattttgga ccggtgtcgc ggttccgtct gagcgaagac ggtaaaattc gccgtcaaac 3391201 ccaatcagct ctccgtcaag cttgttaaag gttccgatac cgaagtctcc atatttcgga 3391261 atctctgaca gttcaaaatc tccgtcatat actccgtcta atagagaagt cattgttgat 3391321 acttgataaa tctggctcac aggctgatct ttttgaccac ggctgagcac ttgaatgttg 3391381 ctttctcgtt tcatatttcc cttcactcct tttatttagt gctgttcata aaacagtgtc 3391441 gtgatgcgca gagtgctaga gagctttcgt tttcatgagt tccccgaatt ctttcggaag 3391501 cttgtcactt gctaaattaa tgttatcact gtagtcaacc gggacatcga tgatgacagg 3391561 accttcagcg ttcatgcctt gacgcagaac atctgccagc tggtctggtg attctacgcg 3391621 caagccagtt gctccgaagc tttccgcata tttcacgata tcgatatttc cgaaatcgac 3391681 cgcagatgta cggttatatt ttttcaattg ctggaatgca accatgtcat atgtgctgtc 3391741 gttccataca atgtgtacaa ttggtgcttt tagtcgaact gctgtctcta attccattgc 3391801 tgagaataag aaaccgccgt caccagagac agaaaccact ttttctcccg gtttcaccaa 3391861 tgaagcgccg attgcccaag gaagcgcaac gccgagtgtt tgcataccgt tactgatcat 3391921 taatgttaac ggctcgtagc tgcggaaata acgtgacatc caaatggcgt gcgaaccgat 3391981 atcgcaagtt actgtaacat gatcatcgac tgcattacgc aactctttaa cgatttcaag 3392041 agggtgcgct ctgtctgatt tccaatctgc aggcacctgc tcaccttcat gcatatattg 3392101 ttttaaatca gaaaggattt tctgctcacg ctctgcaaat tccactttca cagcatcgtg 3392161 ttcgatatga ttgatcgtgg acggaatgtc accgatcaat tcaagatcag gctggtaagc 3392221 atgatcaatg tcagcgataa tctcgtctaa atggataatt gtccggtctc cattgatatt 3392281 ccagaatttc ggatcatatt caatcgggtc atagccgatc gtcagaacaa catctgcctg 3392341 ctctagcagt aaatcgccag gctggttgcg gaacaaaccg atacggccaa aatattgatc 3392401 ctctaaatct ctagaaaggg taccggcagc ttgatatgtt tcaacaaatg gaagctgaac 3392461 ctttttcaaa agcttgcgaa ccgctttaat tgcttccggt cttccgcctt tcatgccgac 3392521 caaaacgaca ggaagttttg ctgtttggat ttttgctatg gccgcactga ttgcatcatc 3392581 tgctgcagga ccgagttttg gcgctgcaac agcacgcacg tttttcgtat ttgtgacttc 3392641 attcacaaca tcttgcggaa agctcacaaa agcggcccca gcctgccctg ctgacgctat 3392701 cctaaatgca tttgtaacag cttccggtat attttttaca tcttgaactt ctacactgta 3392761 ttttgtaatc ggctggaata gcgccgcatt atccaaagat tgatgtgtcc gttttaaacg 3392821 atctgcacgg atcacgtttc cagcaagcgc aacgacaggg tctccttcag tgttcgctgt 3392881 cagcaggcct gttgccaagt tagaggcacc cggtcctgat gtgactaaca cgactcccgg 3392941 ttttccagtt aaacggccga ctgcttgggc catgaatgct gcgttttgtt cgtgccgggc 3393001 aacgataatt tcaggtcctt tatcttgtaa agcgtcaaat accgcatcaa tttttgcacc 3393061 tggaatgcca aatacatgtg tgacaccttg ctccactaag caatcaacaa caagctccgc 3393121 ccctctgttt ttcacaaggg atttttgttc ttttgttgct tttgtcaaca ccctcactcc 3393181 ttattatgca ttttaaacgt aaaattttaa atatcttgtg ataagtttca ctatacactc 3393241 tttggaaatt gacctccaat atcgattcgc cttatgatta atatgtaata cgaattatta 3393301 acctatggaa aggaatgcat attgaatgga gcttcgccat cttcaatact ttatcgcagt 3393361 agccgaagag cttcatttcg gaaaggctgc ccggcggctg aacatgacgc agcctcctct 3393421 cagccagcag atcaaacagc tggaggaaga agtcggagtt acgcttctga aaaggacaaa 3393481 acgatttgtc gagcttaccg cagcaggaga aatcttttta aatcattgcc gcatggcatt 3393541 gatgcaaatc ggacaaggaa ttgaactggc acagcggacg gcccgcggcg agcaaggcct 3393601 tctcgtaatc ggttttgtcg gatcagctac atatgaattt ctgccgccga ttgtccggga 3393661 atatcgtaaa aaattcccat ctgtgaaaat agaactgcgt gaaatatcct cgtctaggca 3393721 gcaggaggag ctactaaagg gcaacattga tattggtata cttcatcctc ccttacagca 3393781 tacagcttta catatcgaaa ccgcccaaag cagcccttgt gttttagctt tgcctaagca 3393841 acacccattg acttctaagg aatcaattac gattgaggat ttaagagatg aaccaattat 3393901 tactgttgct aaagaagcat ggcctactct atacatggat tttattcagt tctgtgaaca 3393961 agcgggcttc agacccaaca ttgtccagga agccacagaa tatcaaatgg tgattggttt 3394021 agtcagtgcc ggaattggta tgacatttgt tccttcctcg gccaaaaaat tatttaattt 3394081 ggatgttact tatcgaaaaa tggaccaaat acagcttaat gcagaatggg ttatcgctta 3394141 ccgcaaagac aatcataatc cgcttataaa gcattttatt catatttcaa attgtcagca 3394201 gacaagaact aaagagagtg atgcaggtac atgaacaata cttgcaatct cttttttctt 3394261 ttgggattct tatggaattt ttattaattt aatataatcg cttagtacaa ctttatatca 3394321 gtatacgtat acatacagta caaatagttg gcaaggacat cagtaagcgc aggacattag 3394381 tttgatttta aaaatgaaag atagagaggt gaagtaaatt attgagttca ccggcatatt 3394441 cacattgctc gcttttttcg taacaatgat ttttattttc tggagaccaa aaggactaaa 3394501 tgaagctatc cccgccacat ttggcgcttt aatggtttta ttgtgcggaa gtgtgtcatt 3394561 ggcagactta ggggaaatcg gaacaaaagt cacgggtgca tcggttacaa tccttgccac 3394621 tatgattatg gccattgcac tagaaagctt tggtttcttt tattgggtgg ctgcaaaact 3394681 gctccaacaa tccaagggtt caggcatcaa gcttttttgg ctaaccaatt tgctctgctt 3394741 tctcatgacc attttcctta ataatgatgg gagcattttg atcacaactc caatcctttt 3394801 gcttgtacta aaatatttag gtttaaaaaa acatcaaaaa gccccatatt tattaagcgg 3394861 tgttttaata gccacagcct ctagcgcacc gattggcgta agtaatattg ttaatttaat 3394921 ttctctcaaa atcattggaa tggatctata tcttcacacc gccatgatgt ttgtccctag 3394981 tatgatggga ctcattttta tgacttgtct actgtttatg ttcttttata aacgtcttcc 3395041 caaaagcctg ccagatatac cgggccattt tcagtctctg cggcatagaa ggtaccatcc 3395101 tcttcattcg ccatcagctc ctttaccaga acgaaatcaa acaaaaatca tgttgtttgt 3395161 gcttgcattt gtttttctcg tcagaatgag tctatttgca gcatcatata ccggtatttc 3395221 tgttcctcta gtcgctgtca tcggatcttt tatcctgttg agctggagat ggatttattt 3395281 caaaacctcc ccaagagact tgttatataa atcgccttgg cacattttta tattcgcttt 3395341 tactatgtat gtcttaattt atggtctgca taatattgga ttcacagagt tacttgtgag 3395401 ttattttgaa cctgtggttt ctggaagcct cgcccatgca actttcgcat caggtatctc 3395461 tacttcagtt ttttctaatc tctttaacaa ccatccagcg ttaatgatca gtacttttac 3395521 cttaactgaa atgaccctga atccttcaac aacaaaaatc atctacttgg caaatattat 3395581 cggcagtgat atcggttcat tattattacc tatgggaacc ttagcaacgc ttatttggat 3395641 gcatatatta aaacagcatg atgaaagtat ttcatggggc gaatatataa aaacgaccat 3395701 tatcatcatt ccgctgactg ttctttttac gttaacatgt ttatattttt ggatcagttg 3395761 gttatttctt tagcacagta tgaaacgaaa aactgccttc tgcttttcaa gagggcagtt 3395821 ttgtatacac tagggaagat gcattgtctt tagatgattt aacttccaaa tgactggctc 3395881 tccacttgcg ttaataagct caatgatatt attagagaca ccctttaata gtccgacttt 3395941 ttctggcacc tctcccatat caaatatgac caattcacca atattttttt tgatctgctc 3396001 ctcaaaatta cgcacaagag gaactttgga aggcacgacc ggcaattgtg agttgtcaag 3396061 agtatacggt gtttgttcag ttgaataagg ggtaaaccat tttaaatgat gcatagatat 3396121 aaaaagtatt ttaaatacgg gtgagaaaaa tacaatataa tcgtttaaaa catttgtaac 3396181 atatccatgg atcgatcgac ccccagttac ataaacttca ataaactggc ctttgacctt 3396241 gtttaatgta tttctatatg aaaaagcttg agtttctgcc tctatcattg gatcttccgg 3396301 attgatcaaa aatggcttct cagtactggt cactattttc gccttgttta tttgatgaag 3396361 atgcaacaag ggaatataaa gataattgca gccatcaaaa ataacaaaaa tatcctgtcc 3396421 gatatctatg agggtgccga caaaccttgt atctcctgaa atgacaacct caacatctgt 3396481 gttaaggaat tgattcaaac ctttcacgat tctcctcctt taactgaaaa agggcatcac 3396541 tttatctgat gctcctccat tatctattaa aatttacgtt tccagtgata gtctatcgtt 3396601 ctgacaatcg tttcatagct ataatcttcc ttttgttttc ctgaactttt tattgaactt 3396661 gaatagcctg gtgatcttga tgattgataa tctgaagatc ttggtgatcg tttagatgat 3396721 tttgatgatt gataatctga agattttaat gatcgtttag atgattttga agaacttttt 3396781 gaacgtgacg aacggccaga tttggatgat tgataatccg aagattttag tgatcgttta 3396841 gatgattttg aagaactttt tgaacgtgac gaacgaccag atttggatga ttgatcatct 3396901 gaagatttta gtgatcgttt agatgatttt gatgagctat atgattttga agaaatgaac 3396961 gaattgctgt ccttatcatt attgtcttcc tggttttgtt catttttttg atcctctttt 3397021 ttgtacgacc cttttggacc taagctgatg ctttttatgt gaaaaggata gatgcgaagc 3397081 acctcttgat ttttcactat agtataatgg ccgtcggcat tatctacaag gataccctca 3397141 atggcttccg gacctccacg attaattgaa acccatttat gagtcagact cttaaaaacc 3397201 tcgcttaaat catcagcttc caaaactcca actggcgtct gctcttctat tttcaaatca 3397261 ggctcgtgtt tacttatact tttgatgtga tggatattaa aatacactac cccatcctca 3397321 tttgtgttta acgcagcgta atcatctccc agccagacca atcttccttt tttagattcc 3397381 ggaccccctt ggttaaattg aactgattgg tttattaaat gtccgattaa gctatgaaaa 3397441 tcatcagcat cgagcatttc ctcagtctca attgttgtgg tgctattatt ggtatcctca 3397501 gtaatacttt tcacatgctc caactgataa taaattattt ttttttcagc ttgtaaagct 3397561 atataatctg attttacagc tgttaatttt ccttttttag attccggacc tccacgatat 3397621 acagtaacaa ttttatcttt cattgagtgc aaaaagttat aatacgatat ttcattattt 3397681 gaatgatatt tcattctcct cttgctcatt caaattcctc ctagtcactt atacatagat 3397741 gataaacata ctgcatatat acgtgtcaca tttatttgtt gaactaattc aatagcctaa 3397801 ttgtcgcttt ttccgcgaat acccattttc acgcattcat aaaatactta aatgatcttt 3397861 gaggtattgt gaacggtttt taatatactc gcagatcaca tccggctcac ggtcaaaacg 3397921 ctcaatatca ttctttttat acgggtccat gaggacaaac ggcctaatcc gttcatacat 3397981 cgccatgatt ttcggttcca tatattctat tgtaaaaaga gattggagcg ttttttctaa 3398041 caggcgcttg taggacttgc gaaactcgga ttcatccaat atccgggcgg ttagtgtatt 3398101 aaatccttga attcttacat aatcggcagc catccgctct ccatggatat ccctgcccca 3398161 agtcgcatca taatcccaag gaatcacctc aaataatccg gtttccccgc ttctgtataa 3398221 tgcgtagttg tggacaaacc cgtcatagtt cgaggtgaat acaataccag caagccagcg 3398281 caaatactta tcgacatcca cgtgttttgt cacttctgac ttaaactgag ctttagggac 3398341 cgtattaatt ttaaaaatca tatcttgtaa ataaaaatca tcttcctcag tccctgtttt 3398401 cttttcatat ccaagctcca gcgatgtttt cgtttccctt tctaaatcgc tcatcagaga 3398461 aaagttggca tcatcatcca ccgcataaaa aatcgcgcca tcagccagct tccttttcgc 3398521 caaataatat tcatctacgg attcaagttc aagataaacc ccttcattct tcccattcat 3398581 ctttacaaac gcaaactctg cctttggaga cagtgtccct agctccgaga aaaaatccag 3398641 agacaatttg tttctcatca aggaagggtc tttatactcc gcatttaagt gaatctctcg 3398701 cgcgccgcgg aatgttttcg gctgataaaa ggaaatatgg tatgacttct ttttgaagtc 3398761 tctgatatgt gatccccgat aagcgatatc aatatccagc cttttttgat ttaccttcat 3398821 cacagctggc accggatcat cgtcccatat atcctttttt aattcacgca agtcttttgg 3398881 atgaacaaac agctgataaa gcggtaaatt ggattgattc ttcatccata atcctcctta 3398941 caaattttag gcttttattt ttataagatc tcagcggaac acttatacac tttttaaaac 3399001 cgcgcgtact atgagggtag taaggatctt catccttaac atatttttaa aaggaggatt 3399061 tcaaattggg ccactattcc cattctgaca tcgaagaagc ggtgaaatcc gcaaaaaaag 3399121 aaggtttaaa ggattattta taccaagagc ctcatggaaa aaaacgcagt cataaaaagt 3399181 cgcaccgcac tcacaaaaaa tctcgcagcc ataaaaaatc atactgctct cacaaaaaat 3399241 ctcgcagtca caaaaaatca ttctgttctc acaaaaaatc tcgcagccac aaaaaatcat 3399301 actgctctca caagaaatct cgcagccaca aaaaatcgta ccgttctcac aaaaaatctc 3399361 gcagctataa aaaatcttac cgttcttaca aaaaatctcg tagctataaa aaatcttgcc 3399421 gttcttacaa aaaatctcgc agctacaaaa agtcttactg ttctcacaag aaaaaatctc 3399481 gcagctataa gaagtcatgc cgcacacaca aaaaatctta tcgttcccat aagaaatact 3399541 acaaaaaacc gcaccaccac tgcgacgact acaaaagaca cgatgattat gacagcaaaa 3399601 aagaatactg gaaagacggc aattgctggg tagtcaaaaa gaaatacaaa taatctaagt 3399661 tttcattgtt tcaataggct gccggcggag gtacggaagc ctattttttt atttgccctg 3399721 tattagatat atgtcatgac ataacatatg caacccgcat catttggttt cctttaaacc 3399781 atttcgttat aatcaaggta tcctaacgat aaaggcggtt gttgctatgt acatatttca 3399841 agctgatcag cttagtgcca aagacacata caagctattg tcaggtaccg ttattccccg 3399901 ccccattgca tttgtgacaa cactttcttc aggaggagcg gtaaatgccg cgcctttcag 3399961 tttttataac gtcgtcagct cagatcctcc gcttctcagt atttctgtta acaggacgga 3400021 aggacgccaa aaagatacag cacgaaacgc agtggagaac ggagaatttg tcgttcatgt 3400081 cagtgatgaa gccatcattg aagatatcaa tgaaacagct gcaagcttaa ggccggatga 3400141 aagcgagctt acacgcacct cgcttcatcc tgttgaaagc aaagctgttt cagttcccgg 3400201 cattaaggaa gcccgcgttc gctttgagtg caaattagag cggcatatta cctttgacaa 3400261 tgatcaaggc atcactacag cagatctgct catcggaaga gttgtctgct tccacctaga 3400321 tgaaaaggtg tatgatgcag aaaagggata tattttaacg gatgaattaa agcctgcctc 3400381 acgattggcg ggaaatcact atgccaagct gggggaagaa ttcacactga ttcgtcccag 3400441 ctgaagagaa ggactattta aatagaagaa actagtcaaa aagaccttat gattacaaaa 3400501 tatcgcctgt aaataactga aaaaatatca aaaaaaagaa cacccagagc aagctcgggg 3400561 tgttctttta tgaaacgttt ttcctttttc ttcgtataaa ggtagattag gaggaattgg 3400621 aatgacaaac ttttggattt taatgctgat cgctattacc atcagtctcg cctctcaatt 3400681 ttttataaag aaaaaatacg gtattgataa atccggctgg cgatataagc atgtcagcaa 3400741 tacacacaaa tggatcgaaa tcactttact tattttgttt gtgttttcac tctccttttt 3400801 tccagttgaa tatttgcttc ttttattttt tattgtgatt gactcaatac gtatttttat 3400861 ggagtggcat tatagacctg aagataaaca gtatatgtac cacattgtag aggtctccct 3400921 tatgtttatg cttttgattt atgtttgtac cctatagtta tttaaatccc cacagccgct 3400981 ccgtctcccc gaggatcggc tccgccttgg agaaagcctt cttcatcaac tttgattgca 3401041 gccgcttgtc ccatcagcgg atcatagtca ccgacaacct ccacgagatg cccgctgtct 3401101 ttcagttttt ggattgtttt gtctgtgaat ctgccctcga ctctgagacc ttcgtattcc 3401161 tctccccacg ttctgcccca tacccagcgc ggttcgctga ttgcctgctg tggatgcatt 3401221 ccgtagtcca gcattcgggt aatgatggcc gtctgggtct gcggctggcc ttcgccgcct 3401281 tgtgtgccgt acagaatttt tggctttccg cctttacaga ccatagccgg catcaacgta 3401341 tggaaggtgc gctttctcgg ttcaagcgtg ttgacatgat tttcatccag tgagaaaaac 3401401 gatccgcggt tttgcagtaa tatgcctgta tcaccggcag tgactgccga gccaaattca 3401461 aagtacaggc tttgaatgaa tgacactgcg ttgccatccg catcgattac ggccgcatat 3401521 gccgtatcac ttcccaccgg cctgctttct gccggtattg cgagatagcc gatttcttct 3401581 gccaattgtt ttgcataacg tttgtccaaa agcctttcaa gcggaatgtc tgcaaacgcc 3401641 ggatcagtca ggacggcatc ccgatctaga aaactctttt tcaatgcctc cacaagcacg 3401701 tgataatact caaatgaacc gtgttcgatt tgggtgaaat catagttttc caaaatgttc 3401761 agtgttaata aaccggtaaa tccctgagaa ttcggcggcg cctgatacac actgtatcct 3401821 cgataatcac ttgatacagg cgctgcccac tcaccccgat gcgctttaaa atcatcgatt 3401881 gtcatgtaac tgccgttatt ctgtaaatgt gagacaatcc gctgagcgag atctccttca 3401941 taaaatgcgc ttcttccttt ttcagcaatc aagttcagac tgtctgcaag ctctttttgc 3402001 acaaaccgct ctcccgggac aggtgctttg ccccttctcg tgaagatgtc agccgtgtaa 3402061 ggcgtggaag ccagcagttc aatattcttt tctgtgtgac gacactgatc agctgataca 3402121 ggaaacccat tttgggcata atcgcgtgcg ggctccaata catctgcaag agacagacgc 3402181 ccgtactcct tcaggaccgc atcccagcta tcaaccattc ccggcacggt aatagcactg 3402241 tcaattcccc gcagcggaat cgcgcttttt cccttatata catctctcgt tacgtttttt 3402301 cctgaacggc cgctgccatt gtagactttt actgcctttg tttcctggtg aaaggtcagc 3402361 caaaaggaat ccccgccaag tccggtcata tgcgggtaca caaccgcaag acaagcactc 3402421 accgcaacag cggcgtcaaa cgcgttgcct cccttatcca gtatgcggtt tccggcttga 3402481 gaagcgagat aatgcggact gacgaccatt tgctttgtac cgatgacaga tttgttcatc 3402541 acaagtcccc ttttttaaga aattttcttc agtataggga gcctgatttt tcacatctac 3402601 tgatccggca gaaaaactga cgaactttct tcttttcgca aataataaga tattttcgca 3402661 ttcatttcga aaacaaatga aaaattatta tttctatacg taacttttat gataaaatga 3402721 ttgctaaaag gctacgaaag caggtggagc aattgagtca tgaatatcaa atccccaacc 3402781 ttgtacttga tgagactgat aaacaaattc tcacgatttt gcatgaagaa ggcagaattt 3402841 cttatacgga tcttggcaaa agagtcgatt tgtcacgggt cgccgttcag gcccgtatca 3402901 accaattaat tgaagccggt gttattgaaa aattcaccgc tgtcatcaat cccgctaaaa 3402961 tcggcatcca tgtttccgtg tttttcaatg tcgaggtaga accgcaattt ttagaagagg 3403021 tcgctcttaa gcttgaggaa gagcctgcgg tcaccagcct ttatcacatg acaggcccga 3403081 gcaagctgca tatgcatggg atctttacca acgatcaaga aatggaagaa ttcttaacaa 3403141 aacggctgta tccattgcga ggcgtcgtca gtgttgattg ccagatgctg atcaaacgat 3403201 acaaaagccg tatgggaatg aagctgtaaa ggagagaaac aaatgaaaaa ccatccttat 3403261 cgggatatga cggccgcaat ggttcgcacc ggcatattag ggttcggcgg cggaccttcc 3403321 gtgattccgc tgatccgcca tgaagcggtc aataaatata aatggattga cgatgatgaa 3403381 ttcggagaaa tattagcaat cgctaatgcg cttcccggac cgattgccac caaaatggct 3403441 gcttatctgg gctttaagct aaaaggcaca ttaggtgcaa ttgtggcgat cctcgcccac 3403501 attctgccta catgtcttgc gatggtgggc ttgtttgcgg ctgtaaatgt gttaagccat 3403561 tcagcaattg ttgcaggtat gattggtgcc gtcacgccgg taattgcggt catgctcgga 3403621 atcatggcgt acgagtttgg ccaaaaagcg cttaaaggtt tcggctgggt taccggcatc 3403681 ctgtttttta tcatcgcttt tatcggcctg caaactttac agattaatcc cggcctggtc 3403741 attatcattt tcttagctta cggggcgttt cattttaaac tgaaagacaa aatcacaaat 3403801 aaacattcaa aagataaagg aatgtcagcc tcatgatatc gatctattta tttatggcgt 3403861 tttttatcgc aaacctactg ggatatggcg gcggacctgc gtctatcccg ctaatgtttg 3403921 aagaagtcgt aaacagatac agctggctct caaacgatca attctcaaat atgctcgcac 3403981 ttgcgaacgc attgccgggc ccgatcgcca cgaaaatcgc tgcgtatgtc ggctacagcg 3404041 caggcgggtg gcccggcttc ctaattgccc tgatcgcaac cgtcgtaccg tcggcgctcg 3404101 cattgatcgt cctgctgcgc atcatccagc gcttccgcca atcacctgtc atcaaaggca 3404161 tgacgctgtc cgtccagcct gtcatcgcgg tcatgatgct cattcttacc tggcaaatcg 3404221 gcgcagacgg catcaaagcg atcggctggg tccaatcgat cgtgattacg ggaatttcgc 3404281 tccttgccat gacaaaattc aaaatgcatc cggcattttt gattattgcg gcgtttttat 3404341 atgggggcct tgtgatccct tatttataga aaaaagcacc tggacaggtg cttttttatt 3404401 ttagcccaga aatgccgttt gatatgacag ctgtttcttc tcctgcgtca ctcttgatca 3404461 tgtgcttgac ttgcagcgtg gttcctgcca ttctcacaga ttgcttcaac tgggacgaat 3404521 tggtttcaac ttgtatccaa acaggaggct ggaccttcca aaataaatag agtgcaagaa 3404581 tcagcaagcc agcaatgacc gacagcaaaa acttcatatc gcatcgcttc ttttcagtaa 3404641 gcggctcgca gcggacagcg cctgatgatc acgaagaata tcgcctggac gattgccttc 3404701 tcccagcaca tagcctttaa aggacattcc cataaaatga aaaatatgtt cgaattgctg 3404761 aatcagcggc agccctttta tttttggatt gtctccgccc actgctatta catatgcctg 3404821 tttcactgac atttgctgtt taaaatcagg aaatctcgga tctctcaacg tctgtgacca 3404881 gcgatcaata aacagcttta atgtccctga catgccaaac caataaattg gggtggcgaa 3404941 tataagaata tggcactgca atatccgttc aatgatagaa tcgtagtcat cttgaacagg 3405001 acgaaagccg ccttgggcgt gacgcagatc ttcaattggt tgaattggat atttctgcaa 3405061 ataaatgtgc tccgcatcga atccttgaac agccttctcc gcaagaacat ccgtatttcc 3405121 gccagaccga gttccgccgt taataaccgc aattttcatg atgcatctgc tcctttgttt 3405181 acgaatgatt ttcttcatca tataatggat tcatcaatca atacagatga ttatttcgat 3405241 taatccaatc gctaaaaccg atttagaaag gaagagaaca agtggaattg aagcagctga 3405301 tcacctttat tacggcggct gaacatgtaa acttcaccct aaccgccaaa atgcttaatt 3405361 atgcacaatc aagcgttacc tctcagatca aatcacttga agaagaaatc ggaacgcctt 3405421 tatttgaacg gctcggcaag cggcttatct tgacagaagc aggaaaaacg ttcaaatctt 3405481 atgcacagaa gatcattgcg ttaacagaag aagcgaaaat ggccacaaat caagtaagag 3405541 aaacaaccgg aaccttaaaa atcggggcga cggaaagcca gtgcacatac cgcctgcccc 3405601 ctatcataaa agaatttaaa caggcttttc cccaagtaaa gctcatattc aaaccatata 3405661 tctccaatga acaagcgaaa gaacagctct tacagggcca gcttgatatc accttcatct 3405721 tggatgtaaa ccggatggaa gacgcactgc acgttgaatc tttgattcag gatgagatca 3405781 aaatggtggc tgctaatgac catccttttc ctgcggattt accagtaaca ttgaaggatc 3405841 ttcaaaacga aactcttctg ctgacagagg acggctgctc gtaccgcacg ctctttgaga 3405901 acaatttgca tgactccggt atctatccta acaaattgga attcgtcagc atagaagcca 3405961 tcaaacaatg cgtgatggcc ggacttggga ttggaatctt gcctgaaatg acagtaaaag 3406021 atgatattgc agcaggccgg atgaaagaac tcaattggca gagcgattgc cccgttttca 3406081 ctcaattagc atggcataag gacaagtgga tgtctgcgcc attaaaggct tttatcgatt 3406141 tgacacggaa aacattcaaa taaaacctct ccacaaggac gacaaggttt ttgagaccag 3406201 ggcacacaca tacaaaaaaa acacttgatg acttagagcc ccaagtgtta cacgtgattt 3406261 ttctgataaa acgttcgcaa aacatgcgtc tcaaggtcag ccaggcggac agggatcggc 3406321 agcctgcttt cttgattgat caagctcatc gtgatctgat agctgctgtc taaatcaata 3406381 taattaccgc aagacaagaa aataggcttc acgtcccgcc gcgttcgcag cgcccgtcca 3406441 tatacctcgc cgtcaatgat aatatcggtg tatgcgccta cttcaatttc aggcgtcacg 3406501 aaatcgcagc ctttgatttt gagataggtt ttcgctatcc caatcgtcgg cttgcccaga 3406561 aaaaaagccg catgggtggc aacgcccata tgattgtaat gcagatatcc gttgccatca 3406621 aacaagaaga catccggctc cgtctccagc tttttcgccg cctcgatgat caagggcagc 3406681 tcgcgaaacg caagaaaacc ggaaacatac ggcacgctga ttctccccat gctgtgcact 3406741 ttttcaatga cttcttttgt atcagcgtca attacgataa tacagcacac tccgtatggt 3406801 tctccatcct gctcccaata ggccaggtcg acgcctgcgc aggtgttgat ggagtctgga 3406861 tggatcgtgg gggataggtt gatacgattt ttaaggttaa attgcacttg taaaaagtct 3406921 tgttcctttt tcatatcaaa tttatgcaca tcaaatacct tcataacgat tgctcactct 3406981 cgacctaaat taatgtgagt ctctcttctc gattctagta tttcaaaatg aggactatct 3407041 gtatctatct cgtacttatt taatagattg ccttcttcat cccaattctt ttcagaaatt 3407101 agtatggaat gctcatactg ttgctcactt tttttcctgc cattttcaaa ccaaattatg 3407161 cttataccgt gcaattgccc atatcggtat tctttttcac tttttttatt cccgttttca 3407221 taaaattcac atgttaaacc atgggccaga ccattcttat atttagtaaa atagatgatt 3407281 tgaccatttg gatataattc gtaagccagc cctgtaaacg gctggccatt ttcgtcttca 3407341 ggattatcta aaatctcatc acttaccgaa gagaaccata aatcctcaaa gtccactccc 3407401 ttttctttta tactcttcat atcatattca ttttccatac tttaaagcct ccggtatata 3407461 atttgtattt tgagttatat attcacaatg tggacatcta ggcattggga caccttctgg 3407521 catcttttta tttattttcc tagcacttac tacatatacc attaaatctt ttaaatccgc 3407581 atcaggtctt tgaagtaacg cttcatttag agcattaact tcggcatgag aacccgcccc 3407641 tgacgtcttt atataacctt ctttaagttc tgtaggcata tttacaattc tatcatgaat 3407701 aagtggatgt agtaccttag gtggcttccc atctatattg tttattccaa aataataatt 3407761 gcctgttttt ttgtccaata caccagctac cgcagggcct ctttgttttt tagttagacc 3407821 agaagattta attctactaa gttcgtttag tacttctgcc cttagattta ttcgatggtg 3407881 aagatcttct ttagacaata caccatgctt atttcttaaa tattgaagcc tagtttgttt 3407941 ttcttcagta gtcttagcaa tattgctaat aaggctttca ttactcactt tattgacata 3408001 tggagcattt ttttggtaca accgatcaaa gtagtgtgcc aatcctgctc caccaataat 3408061 agtaatagct tccagcgccc cttgcttccg cttctcctca gacactttgt ttccgaacat 3408121 atcccggcct gtgacagctt ctgagaatcc gtttgacgca acaaggccgt atgcgcccat 3408181 ttctgtcatt ttgagaatgt ctaaggattt gcctgttttg taggcgtcta atgcgtgttc 3408241 agcagcgata gctgcttttc cggttttgta gatggctttt ccgcctttga aggcccggcc 3408301 tgcccagccg acgactggta tgaatccggc agcggccata gctcctgctg tcacacgctc 3408361 cgcggtggag agtttttctc cggtaaccgg atcaacgcct tcggttgctc ttttataatc 3408421 ataatagcca gtgacttctc cagtaaagtt gcaaactcca tcccatgttt tttcgtacca 3408481 cggtttgttt gcttcttcct cggctttttc ctggagccgt cttgcttctg cttgctgggt 3408541 ttttgcatcg atataggttg ttccttgatt ttctacttca atgacgcttt tgtagacttc 3408601 attgctgtgg aaggcttttt tgtcatagta cataggggat gcgctcttcc cattgctggt 3408661 ggcctgcatg agaacagaat atttggtgag cactgcgttg tccagagatt ctaaattttg 3408721 atattcagtg gtcagggatt catcaagctt atcgacagct gtgattgtat cacgtctgat 3408781 tttttgggca tcgcccatct tatctgcata gtcgtcaagc gtgtacatgt cgagatcaat 3408841 aatatcgctg atgcctgaca aaatagaatc gatttcttct ttatgagcgg agacaatctc 3408901 tgaggctttc aggtctccat tgggcagctc atgatccaaa aaagaagttt ccacatatga 3408961 atcattcagt tcttgatctt taatatctcc tgaaatgccg tttaaaaacg caatttgagc 3409021 agagacaagc gtcagccagc tgtctacgat ttctgcctgt ccctgaaaaa aatctttaat 3409081 attgtccgcg ccatttcctt taaaattatc gcctaaatcg gcaactccct gaaacgcttt 3409141 tttcagcgta ttcagctgct cttcaagcgt ctcatattgc ttttttctgc tcttcgcttc 3409201 ttcgattaaa gattttgatt caaatacttt actcatcgca ctgccctttc tgttctattt 3409261 taccgctatc gcctcgtcct gctctttgag tgaatctacg ttatcctttg tatcctcgat 3409321 atttttctgt accgcttttt tgtaatctcc gagcatggtt ttgatgttct cctcacgctc 3409381 atggtatttt ttcgtataat cgaggctgtt ttttccgttg gatcctgcgg cgccgattga 3409441 tacgtcagca agcgcatctt tgacagaatc taatgttttg atgactgtgt cgtacttcag 3409501 cttaatttct gacataaaaa aagatcacca ccattttagt ttactaattg tatttccgac 3409561 ttcttccgcg aactcttctc cctttttaag aagatctgct gcaccatttg ctatgaacaa 3409621 ttccgatgca tatttagctt tatcccattc aagatcaaaa attttcccgt taatcgaagc 3409681 catatactcg ttatatttat cattcacaat cttagatgct tccgatttcg cctcttctct 3409741 tcccttgtcg aaatcatcgg cttttgttcc cgtccaatgc ttgcccaatt ccggtttcac 3409801 aatttctttg atttcagtga ttgcctcttc ttgcagtgtg tctatgtcct tttttgcttt 3409861 tttcagcttt tcgatcttgt cttccacgtc tgaaattttt ccgttgagcg aacttttgat 3409921 atccgctagc atactttcat aacccatctg aatcacctct taatactcaa aaagtcgtat 3409981 ggaggggctg atgaagatag acttttccat actttatttc catatattat attttaaaat 3410041 agccagaagg cggcttaaat agggtaaatg gcttaattta ggcatataac gctcttgaaa 3410101 tgtaggtatt tgatcttgtt tttgttcgtt atacagctaa taaaagcgtt ttataaaatg 3410161 aaatcaccta atgtcatagt tataaaggca cttgaaagag gcagatgttg ttgatctgcc 3410221 tctttcggcg ctgagcttat tgttcatgtt tatgttcttc atctggtcgg ccatgtctga 3410281 ttttgtcatt tggcttctat tattcccccc ttctgaccct ttggatcaaa agcttgtatt 3410341 agctgcagtc ccagttgtac agaacgtttg aaaagtcttt tttccttaga tcttcaggtg 3410401 tgatgaaaaa attggcgatg ccgacgtctc cccacattga atcgatatca tcgtctgaat 3410461 caatttgtaa cagcatgatg gtgtgttctt tatatgcgta ttcccgggga tcatgctggg 3410521 taaaagaagc gtatccgcca attttatggc caaatccgtt ttcagccagt tcattataaa 3410581 tgtcttcttc atcctcgccg aactgaccaa agaactccat tgtttccatg cccgtatact 3410641 gctcaaattg aaaatctgta ggcagcaccc attccgaaga tttcacaggc tcgactgccg 3410701 cttctgataa aatcggaaaa tcacattcgc ctgtgccaat aaatgaaaaa tcagaaacaa 3410761 gctcgtcatc gttttctacg atattttcaa aatagatcac tctgaaattc ttttgttcac 3410821 atcgatcgtc aaaattcaat ccatagacgt catcatgaac agaaatgtag aactgcagga 3410881 tacctgaaga agggtagccg tcaagctggg gaatgtgcga gaaattaatc tgcgccagaa 3410941 gtttcatcgg ctgtccattt tcgtcagtcg gatatgtttc atgcttgggg aaatagggat 3411001 caccggcaat tttgctgtca tatcgtcctg ttttcccctt tctcacattc agtttcacgt 3411061 attctttcgc tgatttctcc agcaagtcgc ggtacggtct cattttttcg ggcagatgat 3411121 tcatcagatt ctctcctttt ccggcatctc caaggtttta ttttctggtt ttcttctaat 3411181 gtttttcaaa cgaatgttta aagaagccct acttctgcat aattttccaa acaatagtta 3411241 aatagtagca aatgtattca gcaccccgca atagatgaaa aaaagactgg tgcgcaacca 3411301 gcctttcttt ttcatctatt gaattgcacc tgacggaaca accgccttcc gtccgacaga 3411361 ataatactcc actcctgcag ccaaagcctc atccaatgtg tagcagtttc tgccgtcaaa 3411421 tatgagcggc gtttccatca aatcctgata agccgctaac gggaattgtt taatgtcagc 3411481 ccagtcggtt aaaatcatga cggcgtcaga ccctttgaca gcttcctcga tcgtctcttt 3411541 atattcaaca gcttgcggga gaacatgctt tgcatggcta actgcaatgg gatcgtaggc 3411601 tctgatacgg gcgtcgagcg cagcgagacg gtctgcaata acaattgacg gcgcttctct 3411661 catatcgtcg gtattcggtt taaatgacag gcctaaaagg gcaatcgttt ttcccgtcac 3411721 cccaccgagc ctgttcagcg ctttatcaac cagcatcgcc tgctgattgt tgttgacttt 3411781 gataacggat ttcagcagtt caaaatcatg ctcgacattg ccggcaattt gcacgagggc 3411841 gtttgtgtcc tttggaaaac aagagccgcc gtagcctatg cccgctttta aaaactggct 3411901 cccgatccgc ttatcctgtc ccatcccgta tgcgactgct tcaatatcgg cgccgacctt 3411961 ttcacatata ttcgaaattt cgtttataaa actgatctta gtggccagaa aagcatttga 3412021 ggcatatttg atcatctcgg cgcttctgat atccgtttgg taaatcggga tttgaaacgg 3412081 acggaagagc tcctccagcg tatttgctgt tttctcatcg gccgtcccga tcacgatcct 3412141 gtcaccatga aaggtatcat agatcgccga cccctcacgc aaaaattccg gattggatgc 3412201 gaccgaaata ctgacaggct ccgctagatg ttcagtaatc agtccattaa tcaaatcgtt 3412261 tgtcccaacg ggcactgtgc ttttcgttac cacgactgta tctcgtttga catgctttgc 3412321 gatgcgtttg gccgcatctg taatttgctc cagattggcg tgcccgtcgc ttttctgcgg 3412381 tgtgccgacc gctataaaaa tgatgtctgc ctgtgccaag cctttctcat agctcgtttc 3412441 aaagttcagc cgtccatcag ctgtattttt tctcatcagc tcttcaagac ctggttcaaa 3412501 tatgggggaa atgccctttc tcatttcatc aatcttgtga gcgtcaatat caatgcaggt 3412561 tacatgatgt ccaatctcag aaagagaaac acctgtcaca agaccgacat agcctgttcc 3412621 gatgactgtt atattcattg tttccctcca acagttaaat tgctgctttg cagcttccgt 3412681 aatatcgtat gagaacatcc tatcatgaat gcgaatgatc tcccgcatag cctgtcgggt 3412741 acagcctgta cagatttctg aaatgtgatt caaccataca atacactatt atatcgctct 3412801 caaaaagaaa gtggtgaaat gagaatcggc tgttaaaaaa aaccaaacaa ttttcttctt 3412861 ttgaccggct gcggaggctg tctgaagatg gtctgattcc gcaggagaag ctctgcattt 3412921 tccgtcagca tataaggaag ttccgagccg aattctttct ctagaacata aagagcctct 3412981 tgagtgtgaa aatttctcgt tttcacatta tgggcatctg aggctacgaa atggatcaaa 3413041 ttggcttcaa ccagccggag agaaaatgct ttcagctgct tgccgaagat ccccgcaaga 3413101 cttcctgaag taatctgaga tgctgctcct ttttccacaa gatgatacag caaggacggg 3413161 ttttcgcgaa tttccctgtt gcgttcagga tgggcgataa ccggaatata tcctttcagc 3413221 tgcaaatcat aaaaaagctg ctccgcatat cggggaacgt gatcaaacgg aaactcaatc 3413281 aagatgtatt ttgtatcatt cagcgaaagc agctgacgtt tggcaaggtc ttgttccacc 3413341 tcgccgtaga ttctgatttc ctgtcccgga agcacatgta aaggaatgtc ttctttgatt 3413401 aaacgtttgt ttaactgatc tgctgcttct ctgactgcgg ctggctcgtt tttatacaca 3413461 ccgttgttat gatgaggtgt cgcaatgatc gtccggattc cctgacgaac agctgctctt 3413521 gccatttcta tgctgtcggc cgaatcacct gccccgtcat ccattgcggg aagaatgtga 3413581 cagtgaatat cgatcatgtc ctagccccct tttttcgcaa aaataaataa cgggcacgat 3413641 gcacgttatt tatttttgca tgaaattgtc cttggttccg taatatccgt attcagagtg 3413701 cttcgaaagc tttttgccgt tcataatcgc cccaaggagc ttgcttttgc acgttgcaag 3413761 cgcctctttc gcttttgcgg cttgttcttt ttctgttttc ccgcttgaaa taaccagaac 3413821 agaaccgtct gccacgttgc ctaaaatctg tgcatctgct acggcaagaa taggcggcgt 3413881 atcaaaaatg accatatcat atgccgcaca cgcttcgtat gcaagctcct tcatccactt 3413941 cgaggagaga agctcggccg ggtttggcgg gatcgggccg ctcgtcagca cgtcaagatg 3414001 tttttcattc gatgcttgta cagcctgctc catagagctt ttctttaata aaacagatgt 3414061 taagccaacc gtattttcaa gaaaaaaagc cgtatgtact gttggttttc gcaaatcagc 3414121 atcaatcagg agcacttttt ttccctgttg ggcgaatacg acagccaggt tggcggccgt 3414181 tgttgatttt ccttcccccg gacaagccga tgtaatcatg actgatttca tttgccggtc 3414241 cactgaagca aattctatat tcgtgcgaat cgtccgatat tgttcagagt tcaaggattt 3414301 cggctctgtc attgcaatga catttctctg catccgcgag cctctgtttt ttctaagcgc 3414361 caaaatgtcc actccccgtt ttttcagatt ggaaaccctg taaggtcttt gctgttttct 3414421 gctcattcgc aatggtggaa actgtcccta aaacaggtat gtccagcaag gattcgagct 3414481 gctcttccga tttgatcgta ttatccaaat gctcaagcag gaaggccagt ccgatgcttc 3414541 ccgccaatcc ggccgcaaac gcgatggcaa tgtttagtag cggctttggc gatacagggg 3414601 acgggtgttc tgaaacctcg gcttttgaca gaatgctgac attgtcaaca ttcataatgg 3414661 atgtgatttt gtcttgaaaa acagatgcta tagtattggc aatatgagcc gctgtttccg 3414721 cgttttcatc cctgactgat atgttgacca cttgggagtc ctgttcgctg gatacggtaa 3414781 ttttgtcatt cagttcttgg gatgtcatcg acaggcccat ttctttaatg acttcatcta 3414841 agatggcagg gctcttaatg atgacattgt acgtattgat taactgaaga ttggtttgga 3414901 catcgttaaa ttggacttct tttcgttcat ttttcgattg gttgaccaga atctgagttg 3414961 aattttcata gatgggtgta agtgcgaaga aactaatgag tccgccggca gcagtggcag 3415021 ccgcggttac aatcataatc aaaagtatgc gttttgttaa cgttgataat atctctttta 3415081 agcttgtaga ttctcccatg atacctccaa atctcttata acatcctttt ccatctacga 3415141 ttatacaacg ttgaaaccgc atttctccag cttttcacgt gacataattc gacatttttt 3415201 tacaatgcgt tatgttagta ctttttatgt aagcgctata tttactgtgt tgacagtgct 3415261 gtctcatttt ctcttattcg ggcagtcacg ttctctcgca taaaaaaatc ccgctaaagg 3415321 cgtgcgggat ttttatgttg catatccatt tttaatatga gaaatcaaat tttcaagcat 3415381 ttccttcgtc gtcatctcag atgactgctc accaatttca tgtgcatgca tcaaaatttt 3415441 cagaaattct tcttgattca atttcttttc actcatcttt tttttccttt cagcttccat 3415501 taagttgaaa acacgattat tatatgatgc tggttatcaa tttgcaatct ctaatacatc 3415561 attcgacaca tcctattttt tatgtccttt tttaggaaaa actttttaag gccgatgtgt 3415621 tgcgatataa tagagaaatt ggatcttttt attacgtgac tcggttagga gcgataatca 3415681 tgcttcagaa tatgatttcc aaagacgatg tgctggcatc tgctgaacag ttaaaagaac 3415741 ttcttcctta caatgaggaa aatgttcagc tgatcaaaaa agcccttatt ttatatcggc 3415801 aggattcagt ctatcgttta caagcagtga gtccgacgga agttacggct tacgtgcagg 3415861 atgttgtgcc tgtgcgggtc acattgaact tgtttgtcat agtcaaaagc ggctgttcat 3415921 gtccgtccgg aagaatctgc cgccatatgc tggctgtgtt tttatatgta tatgcaatgt 3415981 tcgagcgagt gggtactttt acagagtatt ggctggagag ggaaaagctt gaggaaagca 3416041 aagagctcgt ccgccgccag tttcaggaaa aggtgctgcc taatgaagaa tcactttcaa 3416101 gctggcttgc tttttttgat tcagagtttt ctctctggca ggcacgtacg ccagaaggca 3416161 gccaaaacat gcagggcctc tattacggct acctgtccgc attaaaaaaa catgcgccga 3416221 acaagccgga gctgaaaagc ctgtatcaga ttcattccgc gattgcggtt tggcttcgca 3416281 tgttcacatt gattgaagcg ggcaagctaa accccgaaca agatttttat tccctcaatc 3416341 cgtacgttga acagctgatg gatacaatct acagctctat tgataaatta aaaacgtacg 3416401 cgctgtcttt tgcgcttgat ccgtttttgg ataaaacacc ggatgttatc cggcatttgc 3416461 tgttgaaaga agaaattttc caatatgaac gcatccgcgt cttcggtgaa atttggagtg 3416521 cgctgctgtc gcggccaaaa tgggtggcac gcgaacagga gatattgaaa aaagaagcag 3416581 gacggcgttt ttctcccgaa ttgcaattcg ggcgcctgca tttggaattc ctgcaaaaaa 3416641 atgatgacgt tatttttgag gaagcggatc aattcccgcc ggaagcgctc ccttatacat 3416701 tccaatggct gagtgaaatg actgccaaga aggactggaa acggcttaaa acatggtacc 3416761 agcaaattga accaattgcg atgggttata cgaagctgga taagccgttt aaagagattc 3416821 gcgatgtgat cggcgagctg ttccttctgt tgaatgccta tgtgcagcaa accaatgatc 3416881 aagcgctgtt tgagcgcttt gccgcgggct gtctgccgta tacgttcaca gaatacagcc 3416941 atcatttata tgaaaaaaaa cgctatgccg agtggattga aattcatagc cttgtcggct 3417001 tttccatcaa tgaaatggat aaaatgatgc tcaaggaaat tgcagcgagc gaccctgagg 3417061 cgcttatacc ggcttaccat agagaagtgg cttttttcat tgatcagaag aaccgtagct 3417121 cgtacaagga agccgcccgg tatttgaaaa aattgcgcac cctgtacaaa aaagcgaaaa 3417181 agcagaaggt gtgggagcgg tatattcagc tgctgagctc gcattacaag cgcctgcgtg 3417241 cgcttcaaga agaactgcag aaaggaaagt tgattgatgg cgagtcttaa agaaattctc 3417301 atccacgtcg aacaaatgga agatgggtca tttacgctct cagcctttga tgagaatgag 3417361 cagcctcttc cctacagcca tatgaaaaag catttgttcc aatggcatga atcctcattt 3417421 tacggaacct ttctagagga tgtcagcttc atcgggacga ctgctgtcct tctatctcca 3417481 tggatgactg tagagcttct cggcaaaaac tcgttcaact cattcagctc cgtgcagctt 3417541 acagaagaaa cggagccgct gatcgaggcg gcatcgacca tctatgaatt tatcgcggac 3417601 ggcgatttta tgcctgacta tgacgcatgg acaaacggtg tttttcgctg gaaggaccgc 3417661 gataatatac tggaaggctt tactgcggaa tggttttccg ctgccgtaca ggattacatc 3417721 cagtacgacg atgacctgcg ggagaaatgg gaacatatca aggaaaaatc gcctgcggtt 3417781 acgacattcc gtggccattt tcttgatgaa gaggattttc tggaaggcat tggctggatt 3417841 gacgatcaat ctccatttac tgtcggcttg cgcttaaatg aaccggactt tgacggagac 3417901 gaatggaaga tcgagatgtt tttacgcgat aaaaagagcg gtgctgtaga attctttgac 3417961 ggactgaaga gcctcaaaaa atcgtggcag gcgtacagcg ataaaatcgc gcgtgagcag 3418021 gaccgctttc acagaacggt tccgtggctg tcgtttgatt ccgggacaac gctgatctcg 3418081 gaggaagaag cctggatctt cctgtcagaa gcaagtgaga cgcttgtcga tatgggggta 3418141 gaaatcctcc tgccgtcctg gtggcagatt gtcagagaca gcaacatgat gctgaaagca 3418201 aaggtgtctt cctccccgcg cggcgagtca tttgtcggca tgaatgcact gcttgatttc 3418261 aactggcggt ttgcgacaaa tggaattgaa ctgactgagg ctgaatttaa tgagcttgtc 3418321 gccagcaaca ggcgccttgt taatatccgc gggcaatggg ttaaaatcga tccgcagttt 3418381 atcaaacaga tgaaacgcct gatggaaaaa gcagaatcag agggactcca catgtctgat 3418441 attctggcgc gggagctaat ggatcagcag gatggcggac ttgaggattc ggacctgatt 3418501 gatacatctg cttttgccgg cattcagttt gatctgtcta aacagctcag gtcactgatt 3418561 cgaaagctca ctgccgcgga aaacctgccg gagcacaaag tcagtccttc tttcaaagga 3418621 acgctccgcc cttatcagaa atacggcatg aactggctgc tgtttctgcg ggaaagcggt 3418681 tttggcgcct gtctggctga cgatatgggg cttgggaaaa cgattcaaat gatcgcctat 3418741 ttccttcacg tgaaggaaag cggccgacaa aaaacgcctc atttgattat tgcgccgaca 3418801 tccgtacttg gcaactggca gcgggagctt caaacctttg cccctgatct gtctgtcgcg 3418861 ctccattatg ggccgcgccg gccaaagggt gatgatttcg ccgcgcatta tgaaaacgca 3418921 gacgtggtgc tcacttcata cggtctgtca catgccgata ctgaagagct ttcttctgtg 3418981 acatggaaca cgatctgcct tgatgaagcg caaaatatta aaaacgcgca tacgaagcaa 3419041 tcacgcgcaa tcaggaagct gaaggggctt caccatatcg cgctgagcgg cacgccgatg 3419101 gaaaaccgac tgactgagct gtggtctatt tttgacttca tgaataaagg ctacctcggc 3419161 agtttgaccg gcttccataa acgctatgtg ctgccgatcg aaaaagaccg ggacgaaaag 3419221 agaatcggac agcttcagca attaatccgg ccattccttc tccgccggac gaaacgggat 3419281 gaagaggtcg cgcttaatct tcctgagaag ctggaagaaa aagaatttat ccctctgtca 3419341 gccgagcagg catcccttta tgagcagctc gtcaaagaca cttttgacca tatgacatcc 3419401 ctgaccggca tgcagcgaaa agcgctgatc ctcagcatgc ttggacggct caagcaaata 3419461 tgcgatcatc ccgcgcttta tttaaaggaa gagcaaaccg agctgctggc cggcagatca 3419521 gtcaagctcg aaaaattgct ggaactgatg acagcgatcc gcgcccaaaa cgaaagctgc 3419581 ctgattttca cgcaatacat tcagatgggg aacatgatga agcggctgct tgaaaaaacg 3419641 ttcggggaac ctgtgcaatt tttaaatggg agtctctcca agcaagagcg ggatacactc 3419701 gttgagaaat ttcaaaggaa agaatatccg acactgattc tttcactcaa agctggaggc 3419761 accggactta atttgaccgc cgccaatcac gtcatccatt atgacagatg gtggaacccg 3419821 gcggttgaaa atcaagcgac tgaccgtgca taccgcatag gccaggagcg ctttgtccac 3419881 gttcataaaa tgattacgac aggaacaatc gaagaaaaaa ttgatgtcat gcttgaatcc 3419941 aagcaaaccc tgaacgatca aattatccaa agtgaaaact ggattaccga gctttccaca 3420001 caggagctcg aagaattgtt tacattaagc gctacagcgc aataatcatg actaaaaaag 3420061 ctggctctaa aagagccagc ttttttccgt tcatagccgt cacgccgaat ttccaaaaaa 3420121 tccgttacgc cggttatcaa cagggtgcgc ttttgtggca gcacatatac ttacaacaaa 3420181 tgtttcatca tatgtgcgac accgtgttcg tcattggtta aggtgacagc atcggctatc 3420241 gatttgatgt cttcccgggc attgcccatc gctacacctt ttcccgcagc ctccagcatc 3420301 gatttgtcat ttaaactgtc acctacagca gcagtttcct cgagcggaat attcagctgt 3420361 tttgcaagcc tcttcagcgc ctgccccttg gaagctttgc gggaagaaag ctcaaagttg 3420421 tgctcagccg aactgacaag cgtcaaatct tcggcatgct catatctttt ccagcctgcc 3420481 tcaagctttt ctttgaagaa agaaaagccg agaatattgt aaaaatcgat tggctcatcg 3420541 gcttcaaaca gctcttgaaa ggagttaatg taagcaaagc ccgattggct gtattgcacc 3420601 tcggccgcct gcttaaggac agaaagatcc gcttccggat ttgcgcttct gaatctgtcg 3420661 agctcaacat caagaagttc tctgccgttt tgcggcgtat aaatcgctga acctgtgaat 3420721 acctcataat aatagttttc cgactcaagc catgagagaa tgtcatacgc ccgtttctta 3420781 tcaatcgttt cgtgatgata aagcctgccc tcgggatcgt gaatgacggc gccgtttgca 3420841 ctgatgaccc atgttttgat ccccagcggt tcaaagattg acatgacgtc aaaatgagcg 3420901 cgcccagttg acaccaccac ttcaatgccg tcccgctgcg cctgccgcag tgcgttttca 3420961 ttttccaagc ttacctgatg cttgctgttg agtaaggttc catctaagtc aatcgcaatt 3421021 aatttcacgt ttgtcagtcc tttccttcat cctgctctgt cacgagaagc tcaacgccgt 3421081 ttcggtcaag caagtcacaa aatgcctgat tcggcagcct gtctgtaatc aagaggtcga 3421141 tttcattcag ctccgcatac tgataaaaac tggtgctgcc cagcttagaa tggtctgcaa 3421201 gcgcaattac ctgctttgcc tgctgtatca ttttccgctt caccatgcca tcctcttcat 3421261 gcgcaattgt aatgccatgt tcggaaatgc cgaccacacc aatcagcgct ttatcaacat 3421321 ggtagcttga gagcttttca atcacagagg acccgtacag aaagcggtgc tccttttcca 3421381 gcttgcctcc cagcagataa atttcaattc cctctttatc ggacagcaca tccgcaagat 3421441 taatcgaatt ggtgattacg gtacaatcaa ccgcattcaa atgctttgca catgcctgaa 3421501 cagttgtaga ggcgtctaaa atcacccggt ctccatcatg aataagcgat gctgcaagcc 3421561 tgccgatctt atttttttcc tcagacactg ttttcaggcg gccggaatag ctttgaattt 3421621 tctgatgcac agtcggtaaa atggcgccgc ctcttgtgcg gatgatggca ttctgttcct 3421681 caagtttcac aagatctcgt cgcgctgtat cccttgacac ttgcaggagc gtacagatct 3421741 gctccgttgt aattcggtta tgctgtttta aaaaatccaa aatcgctact aatctttctt 3421801 cttggtacac gccctcattc cttttctcag caatcattta taagtaatta taagttttta 3421861 tttgatttta ttcaacatta ataagtgatt ttaagtaaaa atgcgtcgag agaaccaatt 3421921 tttcctaagt aggcaaaaag aaagaaccag tctggtcgac tggtcaattt tgaggggatg 3421981 atgcgaagat ccggataata gtgaatggat agataacggg aggagcaggg gtgtcaatca 3422041 gcagcttttt cccggggttt agggtccata aaacgaacag tgtcagccaa cacttctgtt 3422101 acatacacgt taacgccttc ctcgttttca tagcttcttg tctgaatccg tccgcttacg 3422161 ccgacgagag aacctttttg gcaatacaac gccgtgtttt cagctgtttt tctccaaagt 3422221 gtgcaattga cgtaatcagc ttcgatttca cctgaagcat tcttgaagct gcggttcacc 3422281 gcgagcgtaa catgtgcaac tgccgcaccg gcggaagtgt agcgaagatc aggatctttt 3422341 gtaagacgtc cgacaagcat gacctgattg aacatgcgat tcctcctctc cttgcggttg 3422401 tatgtattgt aaatgatgca acaagaaaag aaaaacgctt aaaaatggct ttcagcctct 3422461 gtttttatct ttcgttttca tttttccttc agctaaaaac atcttttgct tttttccttt 3422521 gaagaaatat gtacttttta aaaaacggaa aaagatttgc tttgtcagcc agttttgcgt 3422581 attcatgcgc acataggaag agccatccca cgcaaaccac tgaaagctca attttttttc 3422641 cggcattgac agcttgattt tatactgctc catgccatct tgtgtttcgt ataaaaaact 3422701 tattcttcct tttttgttca gatgaacctc aaacacttct ttacggctta acatatatgt 3422761 tacttccttt tgaatcaaat gactttcaga aggaacgccg tcaatataaa tttcttttaa 3422821 acgaaattga ttcataccac atctctccgt aatccatagt cagttacagt ataatgaaaa 3422881 aatagaaatt attaaatgtt tcgctcatac aaaattcttt agccccaaca ttgcaggatt 3422941 ttttcctcga aaacgtttat gttataatgg aaggcaagaa aactttggaa gtaatcgggg 3423001 tgagaagaaa tgaaaacctt taaactggtt gacctgaatg tggaacgagt ggacaaggaa 3423061 gaacaatcaa ttgaacagtt tccccttatt gacggactga ttataaataa agaagacggt 3423121 gaaaatcact ggctgattga ggcgcttgta cagaaagaac atctgtcttt ttttgaacag 3423181 cttcaaaaca gccaatctga agccaaagta tttgtaacga tcacgaaaaa aagcaatcgc 3423241 cccgcccagc tgacagcagc agtgaaaaat atcgtcaagc tggaagaaag cattcaggtt 3423301 ttactctacg gacaaatggt cacaagaaaa cagcagggca ctgaaaccat tctcgagtcc 3423361 cttgtaaaag agggctatac aggaacaaaa ctcattgagg catttaagca aaaattataa 3423421 atatgagggg gcatgttccc caaaacagac tcagaaccga agagcatcac aatagacatt 3423481 tagaatagat atgttctgca tgaaaaaagc tgccgttttg aacggcagct tttctcttcg 3423541 tgctttcact cttgcatatt taatttgtat ggccaaaaga atcaaccaat tcccctttca 3423601 caacgaggcg cccttcggtt ttgaccgcct tgtcacatgt gattaacgta atctcctttt 3423661 tgtttgtctc ctcaactaca tctgcatcca tttccgatat gatgtctttc gatgttacag 3423721 aatagatata atccttttta aaatccgtga tgacaatttg ggcacctgtt tttatgtttt 3423781 ccagaggtcc gaacagaaga ttcttttgct tcaaatgatg gcccgccaac ggataatttc 3423841 cctcacccat tttttgatcc cggcgcattg ttgccgcccc tatcaaaaga ttttcattgg 3423901 ttgtgccttt tacgatcgga agctccagat cgacactttt aattgttatc cgccgccttg 3423961 attgtgaagt aaaaataagt atatttcacg tgctttcgac gttctccact tgactggaat 3424021 gctttaatgg cgatcccggc atctgtagct tcaggctttc cttcagagga atcagaaatc 3424081 tcaaactcta ttttctcagt gttcagcaca taaccggctg gcgctttcgt ttcaacaaaa 3424141 gcgtattgtc ccggtgcaag gcctgaagct gtgacttgat gatgccggat atgactggtt 3424201 tcgaagtctg tatgaaaatt cgcgaacgat tcagcatggt tgatcttccg gttctgatca 3424261 ttacagctgc cattatcggc catgacaaat acaaggcttt tcatgccgga gcgaatgaca 3424321 ttttgcaaaa accctatcat tactctgaat ttatggcgcg tattcaaaac ctgataatga 3424381 tgaaacatac agcaaatcaa gccacaagaa tggaaatggc gtttctccag tcgcaaatca 3424441 agcctcattt tctttataat gtattaaaca cgattatttc tctcactcat ttggatattg 3424501 aaaaggcccg ggaggtaaca gaggaattta ccaactattt aagaatgagt tttgactttc 3424561 aaaatacatc agccatcagt tccttcagac atgagctttc gattatcaat tcctatcttt 3424621 ctatagaaaa gacgcgattc agtaatcggc ttgaggttct tttcgatata gatgaagaca 3424681 ttgactttat ccttccgcct ttaatgattc agcccttggt ggaaaatgcc gttcttcacg 3424741 gtgtcagcaa gaaaagaggc ggaggatgga tcaaactgac agctaaaaaa caaagcaaaa 3424801 atgagtatca catcaaagta gaggataacg gtcccgggat aactccggaa aaacaaatag 3424861 atctcttatc aacggatttt gatcgcagcg tcggattgaa aaatatcaat cagcggctga 3424921 aacatttttg cggaagcgag ttgatgatca gcagcactcc ggatgcaggc acctctgtct 3424981 caatgctcat tcatctcgct gaaacaacag gaagccctaa agaactgaag gacacagaac 3425041 gaacctaaac gaaaattgag ataaaaaaag acgccgtttc taacggcatc ttttttattc 3425101 cggcgacttt gcttgctgct tcagcaggtc tctgatttct ttcagcagct cctcctgcgc 3425161 atccaccgct tcctccgcag cctcttcttc tgcttctttt ttgcgcctta acccattcaa 3425221 agtccgaatg acgataaaaa tggagaacga tataattaag aagttcacaa tcgtctgtat 3425281 aaagctgcca tatttcacta cagcatcgcc aaacgtaaac gacaggcctg aaaagtcaag 3425341 ccctcccagc agcaaaccga ccaaaggcat aatgatatca tttactagag atgtgacgat 3425401 ctttccgaaa gcgccgccta tcacaacacc aatcgcaagg tctacgatat tcccccgcat 3425461 ggcaaaggct ttaaattcat tccacataca atcacctgct tttctatatt tgtaaagaaa 3425521 aaaagacaaa tgtgccgctg gccatctgcc ttttttcaat tattctccga gggcaaaagt 3425581 cagttctact tcgcaaacga cttcgccatc aactgtggca acgccttttc cgcgcccgat 3425641 tgtgccgcgg gcacgaatga tttcaacctc aaggtgaagc tggtcaccag gcttgacttg 3425701 ttttttaaag cggcagttat caatgcctgc aaaaaaagcc agtctgccgc ggttttcttc 3425761 tttaatcaac atcgcaacag ctccgacttg agcgagtgct tctacgatta atacgccggg 3425821 cataaccggg tactgaggaa aatgtccgtt aaagaactct tcattagcgg ttacattttt 3425881 atagcctttt gcccgtttgc cctcttcaac ttccgtaatc cgatccacaa gcaaaaacgg 3425941 ataacggtga ggaataattt ctttaatttg ctgagtatca agcattgtct tgacatctcc 3426001 ttcatctgca ttagtatgta tagcaatcat caaagatcca atctgtacat ttgaaaagta 3426061 tattatgaat taatctcttt ttcaaccgcg ctaaaatgta accaactgtc aatgagagcc 3426121 gtcaaaagtt atgatatgat aattatagat tttaccaata gcaaagaggt aggaaaatga 3426181 tttcgaagtt tattgaaaaa agaatgctaa acatgttaga cgagtggtat tccgcaatga 3426241 gcaaacgcaa aatgaatcac gtttgcacac tgaaagagaa aattgatcag caccttccaa 3426301 agatcaaaaa gaacacaaaa ctttggatgc gttatcaatt gtttcaggcc cgccatcagc 3426361 tgctttttga aaaccagaac ggactcgatt cattgttcga tggcctatat ggcctggaag 3426421 acaaaatgga tgatgaattg aaatattatc tgtatttttt ctctgggtta tatgagatgg 3426481 taaaaacagc tccgaaacat gcagtacatc attttaaaaa agctgaacag tacctggccg 3426541 ccattcacaa tacgtttgaa gccgctgatt tatattatca aaccgccggc gcctattact 3426601 tgatgaaatc accgccgctt tccgtccaat acgtcaaaaa agcattacac atctatttgc 3426661 accaattcgg ctatatcaaa aaggtaatca cctgtaaact tttgctcgcc gtgaattata 3426721 ttgatcaaga acgctatgaa aaagctgaac agcttttcaa agaaatcatt aagaaaaccc 3426781 agcaactaca tgacgaaaac ctgctatgcc acgcttatta taaccttggc tttttaaaag 3426841 cgaccgagaa aaaagaccag gaagcgcttc tttactttag aaaagtatta aagaatcaag 3426901 aatttgaaat gaattcacca gtctcatatc ttcattgtgt gtacgagtct gtcagagcgc 3426961 tttttaaaac agggaacatc acagaagcta aagccgtcct tcaaaaagga aaagaattat 3427021 ctgaaaaggt agacattcaa accatttatt taaaattaaa aacgcttgaa gccctctaca 3427081 catcagccga agacccttat gagcagctgc tcgaatatgt gcttgaatta gaaaaaatcg 3427141 aggcgtgggt ggatttagaa gtgctgttag aagatattac ggaatactac aaaaaaaagg 3427201 acgatttcga aaaagccgct ttttttatca tgcgcggctg attgaaaaac gcccattttc 3427261 ttattatctg actgaattga ttaaaccgag catttgatct cccattgtga tcgttctgct 3427321 gttcagctga tatgaacgct gggacgtgat caaatctgtc atttgttctg aaatatcgac 3427381 attggacatc tcaagtgagc cctgctgcat gccgatgttt tgtctattag cgccgttcag 3427441 ctcttcaaaa gctgccgcat tatcaataga gaaaaggtta ttcccttcgg atttcagctc 3427501 ttgagggtta ttcacttgga caacgccaag attaaaccgc tgaaccgcgt ttccgtcaga 3427561 tgcggttaag gtgccgttct tattaatggt gatattcttc attgagctgt cgatgttcac 3427621 tgtattgccg ttctcatcaa gtacgggata cccatttcca gtgacgagct gcagctggtt 3427681 ggcattcgca gcggacggcg ttacatacag cgccccgtcc ctcgtatact ggcggtttcc 3427741 atttacattt acctgaagat actggtatgg agacgtaaat gcgatatcca gatcgcgatc 3427801 ggtcttctga atgcttcctt gatcagagac taggcgtgaa ctcatcatcg ctccgacgcc 3427861 aaggcgcaag ccgggcggcg tttttcgggc ttttgccact tcctcgtttt tttcatcaac 3427921 ctgatcgaat tgctgtctga caagctcaga aaaattcgta tcttttgcct tatagccggt 3427981 tgtgttgctg tttgaaaggt tgctgctgat tgtgtcaatc tgctgctgca gctggtttaa 3428041 ggttgttgat gccgttagca ttgacctgag catagttgat gtcccccgtt tttttcttcc 3428101 gttttcttaa atttttccaa tttcatttgc tgctttatcc atacttttat cgtaagcctg 3428161 aataaccttc tgattcgcct caaacgatct gtacgcttca gtcatttctg tataggcgct 3428221 tgtcacatcc acgtttgaaa gctctgagac gccttgtttt aatgaatagg ctacctgatt 3428281 atttccggct gcgcttggca gatcattacc gtccgccgtg ctgtacaaat catttccgtc 3428341 ccgtttgaga ttgcggacat cttccgccat tctgacatca atctggccgg ctgtgcgtcc 3428401 gttcgttgtc acagtaccgt tttcagacac agtgaaattc tcattatcaa cagtgattgg 3428461 ctggcgatcc gtcgataaaa tagggcgtcc gttgatcgtc agctgattgt tctcatttag 3428521 tgaaaatgtg ctgctttttg aataacggat tccatccgct gtttgaaccg gataaaaaag 3428581 agcagctttt tcattggttt ccgcactcat cggaacttga ttttcgatca atgcaatgtc 3428641 tgtaggctgg tctgtggact tcaggcttcc ctgtgtaaag agaggcttga gctcctgcat 3428701 atatactccg gtattcacgg aaccgatttc cgtccttgat gtcccggccg gagattttga 3428761 ttctattctg ctgagcagca tctcagggaa cgcgcgcata gagccttgat cagctttata 3428821 tcctgatgta tttgcgttag caatattatt tgaaagcatt tccgttcttc gctgctgggc 3428881 aatcattgcg gatgttgctg tatataatcc ttttaacaaa tttcccacct ctaaaaatgg 3428941 cattttttcc agttgtcata taggaacgtt cgttctataa taaaaactca gtattttatc 3429001 ctattatcgt catttaacat cttttcgtga aggctttttc ataaaaaaac ctcattcttt 3429061 ttcagaatga ggtttgtgaa atcagcttag tttgcgttta ggaagcttgt ccatattatc 3429121 aagcatgaca cctgtgccga tggctacgca atccatagga ttttcagcaa cgaggaccgg 3429181 taccttcagc tcttcagcaa gcagctggtc aaggccgttt aagagcgcgc ctccgccggt 3429241 aataataacg ccgcggtcaa taatatcagc agaaagttca ggcggtgttc tttcgagcac 3429301 ttgttttgca gcctgaacaa taacagcgac agattcacga agggcttctt caacttcttt 3429361 actgtttact gtaattgttc ttggaagacc ggaaaccatg tcccgtccgc gaatggaaat 3429421 ttcctcgtga cgtgcgtctg ggaaaacagt tgcgacttta atcttaatat cctccgcagt 3429481 acgttcgccg atcagcagct tgtactcgcg tttgatataa tttaagattt ccatgtcaaa 3429541 cttgtcccca gccattttaa tagaagagga ggtgacaata tcgcccattg aaataaccgc 3429601 gatatccgtc gtcccgcctc cgatgtctac aaccatgtta ccgcttggct ggaatatttc 3429661 catacccgcg ccgatagcgg caactttagg ttcttcttca aggtacacat gtttcccgcc 3429721 gcttttttct gcagcttctt taattgcttt ttgctcaacg gatgtaatat tcgtcgggca 3429781 gcaaatgagc atgcgcggct ttgagaacag gccttttaca ttcagcttgt taataaaatg 3429841 tttcagcatt gcttctgtta cttcaaagtc agcaataact ccgtctttca gcgggcgaat 3429901 cgcaacaata ttcccaggtg tacgtccaac cattcgtctt gcctcttcgc caaccgccag 3429961 cactttgccg ctgtttttat caagtgcaac aacggaaggt tcattcagaa caattccttt 3430021 acctttaaca tggatcagta catttgcagt accgaggtca ataccaatat cccttgcaaa 3430081 catctattta tatcctcctt gaaaatctgt ttcacagtaa atatccacat tgtgccctaa 3430141 ttatatatat tatcataaaa tatagaaaaa aagttggaag cacaataagt tctttacaaa 3430201 tttttgcgga tgttttatga acgatttcaa gaaggcaatg ccaggtgatt acgattgctg 3430261 aacaggctct ccttcgagaa tttcatcttt tttatatttg agctttgtcg cttctcctcc 3430321 tcttaaatgc ctgatggatt tatgataatc gagtatttct ttcacttcgt ttgccaagtc 3430381 ggggttaatt tcaggcagac gctctgttaa atccttgtgt actgtacttt tggaaacacc 3430441 aaattccttc gcaatgacac gaacggtttt ctttgtctcc acgatgtact tccctatctt 3430501 gattgttcgc tctttgatgt aatcgtgcac accactcgac ctccctaaaa tggatgtgag 3430561 aagtgtgaaa tgagatccgt attctgtaaa gagtcgttca ttatgccgct tcttcgttgt 3430621 atggttttaa aagtaagttt gtgaaatatg cccacgatcc ctcacctcaa acactctctt 3430681 tgttaggttt gtaacagtgt attagcattc ttttgggaat atgctaaaaa ctcaataagg 3430741 acaaggggtg aaacgaactt tttcagattc agcaaactat ttcgcgtcac taaattttca 3430801 tctttacaac tattgatcgc tcctgtaaaa tgaaataagc aattagttac ttaggtaagt 3430861 tttttagaag gagaccgaca tgtcctacgt caacagacac ctcattcatc aaatcaacca 3430921 aagcgcccgc ctgattgcca agaaagccaa tgaacagcta gagccattcg gcctttattc 3430981 atctcaatgg tcagttttat attgtttgcg tacgatcgga ccaatgactc aaaaagagat 3431041 ttggtcctat ttaaatgtgg aagcgccgac tgtgactcgg acgatcaaac gcctggagga 3431101 gaacggctgg gttcagagac ggcaaggtga agacaaacgg gaaaaacttg ttgtcctcac 3431161 aaaagaagcc gagaaaaaat acgaagaaat caatgtgaaa atgttgaaat tcgaggaaga 3431221 gctgcttgca gatttccggg atgaagataa agaagctttt tctcatttat tccgcatgtt 3431281 tttacaacaa tgaaaataag gaagtgacat acatttgaaa aaagcggatg cgatatggac 3431341 caaggatttt attatggtcc tgcttgtcaa tttatttgtg tttgtgttct tttatacatt 3431401 tttaactgta ttgccgatct atacactgca agagcttggc ggcacagaat cacaaggcgg 3431461 gcttttaatc agcctgttcc ttctgtctgc gatcattaca cggcctttct ccggagccat 3431521 cgttgagcgt ttcgggaaga aaagaatggc gattgtatca atggcgctct tcgccctatc 3431581 atcttttctg tatatgccga ttcataactt ttccctgctg ctcggattgc ggttcttcca 3431641 agggatttgg ttcagcattt taacgactgt tacaggtgca attgccgctg atattattcc 3431701 agccaaacgg cgcggtgaag ggcttggata ctttgccatg tctatgaacc tcgctatggc 3431761 gatcgggcct ttccttggcc tgaatttgat gagagtggta agctttcctg tattctttac 3431821 agcctttgcg ctgtttatgg ttgcgggctt acttgtttcg ttcttgataa aagtgccgca 3431881 aagtaaggac agcggcacga ctgtattccg ttttgcgttc tcggatatgt ttgaaaaggg 3431941 cgcactcaaa attgcgacgg tcggtttgtt tatttctttc tgttattcaa cagtcacatc 3432001 atatctgtct gtattcgcca aatcagttga cctttcggat atcagcggat atttctttgt 3432061 ttgttttgcg gtgacaatga tgattgcacg cccgttcaca gggaaattgt tcgacaaagt 3432121 cggaccgggc attgtcattt atccatcaat cctgattttc tctgtcggac tctgcatgct 3432181 gtccttcaca catagcggct taatgcttct gctttcaggg gcggttatcg gtcttggcta 3432241 cggatcaatc gttccttgca tgcaaacatt ggcgattcag aaatctccgg ctcaccgctc 3432301 cggttttgcg acggcaacgt tctttacctt ctttgacagc ggaattgctg taggatcgta 3432361 tgtattcgga ttgtttgtag catctgccgg cttctctgcc atttatttaa cagcggggct 3432421 gttcgtttta attgctctgc ttctctacac gtggagccag aaaaaacctg cagaggctga 3432481 aggaaaagtg tctattgcag aataacttgt cagactgccg ggaaatcccg gcagtctttt 3432541 ttccattaaa acacggcgcc ctctcggttg aacgagagaa cgccgcttat agcaattatt 3432601 caatgacagg ccgcgcaggt gaatcaggat ctaacgaaaa atcataggac gcttcatcac 3432661 gaaacatcgg atcggcatat atggattgtt gatcgttttt tgttgctttt cgatacgaag 3432721 aaaatgaatc atattctttc tttttccaca tccatatgcc gtcttgatcc gcttccttgt 3432781 ggtacacgtt atgattgacc gtattacctt cgttttctgt aaagtcgttt ccgataaata 3432841 atctggaatc accggccgtc aatatattct tttcaattgt gttgtttttc gtatcgtact 3432901 gcagcagcag ctgtccgccg tacagtccct ttgtgtcatt ccggtacata atattgcggg 3432961 caatcagaga attgctggtg ccgccccgct ttttgtcata tcctccgatt gaaataccgg 3433021 tgtacgcatt gttgtacact ttgttgtctg tgatctgaat ggcatttgca tactttcctt 3433081 tgtgttcaga cgttgcttca atcccaatat cgttatcgta aactgtgttg ttcttaattt 3433141 cgatatcgtg tcctccatcg acataaatcc cgcccgctga gtattcatct ccataagcag 3433201 gattgccgta agtcgagttt tgataaactg tattgttttc tacgactccg tttcgcacgt 3433261 aatcgttttt atccgcggtt ccctcataac caattagatc aatcccgatg ttattattgt 3433321 tgcggaccac attgcctgca actgtgaagc cgtcgatatt accgttcagc acaactgctt 3433381 cactcgctcc aagcgtcagt ttctcaactg tattgtcctc gattcggatg tctttcatgc 3433441 tgccagtccc ataaactgcg attccgtgag catttccttc atccgctgtt gtcttaatcc 3433501 cccggatgtg attatcctta atggcgatat gactgctgga ccctgataca taaatcccta 3433561 tagcagttgc ttcctcagat gaaacagaaa gatcttgaat tgttaaaccg ctgatggcaa 3433621 tgtcatgttt atcgtgaata cgaataagcg gtgtttcata ttcagcgttc gcaacggatt 3433681 caccgctaat cacgacgttt tcattttcat agtttcggaa tgtgataggc tttccgtccg 3433741 taccgctgtg ctttacatca agggtctcat gatacgtgcc ctcccgaatc atgacagttg 3433801 tgccggcagc agccttctca gatgcgtgtg ccaatgtacg aaacggcttt tcttttgttc 3433861 cttcattttg atcactgcca tttggcgaaa catacagata atccccagat ccttcctcat 3433921 tcgcttttgt cttatcataa acgaaagcga ggatgacaga cgttaaaaca cccgccaaaa 3433981 gaataaaata ccattttctc attttcgatt cccatttcgt tttagaatag atttctaaaa 3434041 ccattataaa tgttctattt atggaaaacc atttcaaaaa tatgaaaata taccgtctaa 3434101 atagatctta ttcagcctgg cggacctgcg catgttcaac tgtttcaatt gccaatgatg 3434161 caggcgggtg aacacgcatc agaacaatgt agaaaagaaa ggaaatcagc acacctacaa 3434221 accaagaaat atcgtataag ctcttcaata caggaacata catgccaatc agcgaaatca 3434281 gcgctcctaa cattgtggct gcaaacgcac ggtaattgta gcccttccaa tacacatacc 3434341 gtcctgtttc ggaatacagg tcatctaccg agagctcacg tttgcgaatg ataaaatagt 3434401 cggccatcat cacgcctgcc accggtccaa gcatgccgcc tattaagcca agaaacgcat 3434461 acacgcttgt cgcgctctcc atcagcttcc acggaaccgt aaataaagcg agcaacgctg 3434521 tgataaagct gccacgtttg aaattgatat atttcggcag ggcattcgct atatcataag 3434581 cgggtgatac gatattcgcc gcgacattta cagagatcgt ggcgatgcag agtgtgatca 3434641 cggacaagac gatgacataa gggttatcaa accgcgccaa aatatcgaca acatcccaaa 3434701 tcggctctcc gaacgcgacc tgcgagccgg aggtcaccgt aatacttgcg aatgcgaaca 3434761 gcgcaaacgt tcccggcaaa ccgtaaaatt gtcctttgat ttgctctttt tgtgtttcag 3434821 caaaccgtgt aaaatcaggt atatttaaga tcaatgtcgc ccagatgccg atgatgccag 3434881 taactccggc agcaaacggc cagaatgttt ctgaaaacgt atgaaacttt cctggttgag 3434941 agtatatcgg gcccaatcct ccagcaatat caacggccca ccataccatg ccgccaaata 3435001 ccagatacac taaaggccct gcccacacct caaaacgttt aatcgactcc atgccgtgat 3435061 gcaatacgag taaatgaatg gcccaaaaga atacaaagga aagcaaaccg gacaagtgaa 3435121 tgccgagaat gttccactcg ccgccaattt ctccccaacc tggccacata ttcaaaagca 3435181 aaatgttcag tgccgtgcta cccgcaaagg tctggatgcc aagccacatg atagctgtaa 3435241 acgcccttag aagcgcgggg atattcgcgc cgtatatccc gtaagaagcc cgaatgatca 3435301 ctggaaacgg cagcccgtat tttgtccccg catggccgtt taaggcaaga gcgccaaata 3435361 ggataagtga tgccgtaata atgatcgcca gcacctgcca aggcgaaagg ccgatcgcaa 3435421 ttaatcctcc cacggtcgcg taggtcggta tgttatgtat acatcccatc caaatggagg 3435481 caaagttcat tgctttccac gtccgttttt cctgtcccaa aggcaccaga tcttcattgc 3435541 tcagcctgtt ggattgctgc tgactctctt ttaatttcat agccggctcc cctttccata 3435601 ttgtctatat gtcgtcacac gttatgtttt ttgacattag atgtcactta atataactga 3435661 agagtcagac aataacactg gctatgatat acaattttcc cgtttgtatt tgaacagctt 3435721 aaacaagaaa aagagacaga cctcagagcc cgtctctttc ttaagatgca gttttcatta 3435781 atgcagcaaa tctcacagcc attaacaggc ttgctccgcc cgctataatc ataatgattc 3435841 ccatcatatc aaaatgggct gccgtgattt ctttaccaaa aagaatgcca aggatcaccg 3435901 aagacaaaat cgatcctagg taacggcagg tttgaaacag gcctgaagtc gttcctacca 3435961 tgttggaagg actcgtttcc agcatcgctg cctgaagcgc gacattgccc agtccgtagc 3436021 ctatacccaa gagcgacaga atgaggcctt taccgatggt ctggacattg ataaaaaaga 3436081 tggttaagag cacggctcca gccgtcatca aaagcgctcc cgcaaagatc ggcttgacga 3436141 caccagatcg gtcgatccat ttgccggtta gaggtgacac aacgatgctc attccagaca 3436201 taaacagcat aaacaggccg ctcgtttgaa cagaaagatg catttcatcc tgaaagtaac 3436261 ttggcaaacc aaaaaataaa caatagaaga aaacattcaa taaaataaac tgaacataca 3436321 cggctgacag gtttcgctgt gttttaaaca gacggacatc aataaacggc ttatccgttt 3436381 tcagctcgcg ccagacaaac gcacagagca gaagcaagcc aagcacacct tcaaccgcat 3436441 gcggcgacgt gctgaacgac agcaaaaagg atagaaggaa aatgattccc ccggcaaata 3436501 aaacaattcc aagaatatcg agctgccgaa taatggtttt gattcctgcc ccttttttct 3436561 gatctttcgg gaacatatac aggcccaata agaagctgag gataataaac ggcaaattaa 3436621 cgataaagat cgccggccag cctccccata caatcaaaaa cccgccggct gtcggcccca 3436681 gcgccgtcat ggcggacgca aaaatagaga gtacagccaa ggctgaagct tggcgctcat 3436741 gaatatgatt ccgaatcaag ccgacacctg acggataaat cgcactgctc cccaccgatt 3436801 gaaacagccg catgaccaat aatgtcataa acgtcggcgc aaacggcgcc ccgatggcag 3436861 aaaccgcaac aagaataagc ccgaataaaa acaagcgttt ccgcccaatc aaatcaccga 3436921 gctttcccgt tacgggctgc gctacggcac tcgccaagta aaacgaggaa atcagccagg 3436981 aaaccgttgt aaacgagagg tgaaactcat gctggatgct atggagcgca agagagatca 3437041 tagacgagtt cagcggattc agcattgttc ccgaagccac agctgttaaa aaaacagctc 3437101 ggcttttttt cgataacatc atttcacttg ttccagaaac tcttccgttg tccgcgattt 3437161 accgattctc gggaaaataa agcgcagtgt ggcttcatgc tcttcatcgc taaatgtgga 3437221 catggcatct gtaataaaaa tctgctgata gccaagctga aatgcctccc gtgctgtgct 3437281 ttccaccccg atattcgttg cgatgccgca caatacaatc gtatcaatgc cgcgacgtct 3437341 cagctgcaag tctaaatctg tgccaaaaaa agcaccccat tgccgttttg tcacagtata 3437401 atcgccatcc tgcacaccga tttccggaac aaattcggcc cagtccgccg gcatttcccc 3437461 tgaacctccc tgcgcaggct catccgtttg cggcttcagg gcgtccgctc catcatgaaa 3437521 ggctacattt acaaagctga tgaacccgtt atgtttccga aattcatcta cgagcttttt 3437581 cgcgttcggg acaacctggc cgctttgatc aatcggcaca attccctttt gtaaatcaat 3437641 gataaccaat gctgtttttt gaaaatcaat gttgagtgta ttcatcatac gtctcctcct 3437701 gatactgtta gtgtttctca cattgcatat tttactcttc acactgccta agttctttta 3437761 tgatgcttgt gaaattctca gaaggagcgt tttctcatga tttttctttt atgtagtagt 3437821 aacaggttgt gcatacgaac aaaccggcaa gcactgtaat cataaagggc gtcatcgctt 3437881 catcacctgc ctgctgtcta tcggttcctg cctgaaaatg cccatgaatt tgcggcggtc 3437941 catccaaagc aggataagac acataaccat taatatcgtg ctaagatcct gcacgccaat 3438001 atcaaaacaa tagttaatca agacgatgtt cacaataatg ggcataaaaa taaccgcccc 3438061 taatgcagcc gttcgcggaa tcagtaataa aacagctgcc aggatttcac caaaacctat 3438121 aaacagttca tagacatgag aataaccgaa aaatgtccac gcgatcgtaa accccttccc 3438181 ggcagccgcc tcgatttcag gcgtcacctc gccaaactgg ccaattacca ctttcgccag 3438241 accgtacacg aaaaaattaa aggctaaaaa caatcggaac gtcgcgggaa tcgacttgcg 3438301 taccgctttc ctcagcctgc cgcctttatt catcatacat ccccctcagt gtattatttg 3438361 atgtagtaca cttaatacag tatagagtat tctaattaat gtcaattccc ttttcagctc 3438421 atatgaatag tttcttttat agatacaaag tcttatatcg caaaaaatgc cattctcctt 3438481 cctttccatc cctcgataac atttctcaaa aaccatgtca ggaaatctta catgaaaatg 3438541 ttttatcatt cttttttctc tataatgaag aaatataata attgcttttt attctgaaag 3438601 atacggagga atgagacatg caaatgggcg atacagtttt tatgttcttt tgcgctttac 3438661 tcgtgtggct gatgaccccg ggattagcgt tattttatgg aggaatggta aagagcaaaa 3438721 atgtgctgag cactgccatg cacagtttct cttccattgc catcgtttcc atcgtttggg 3438781 tgctgttcgg atatacactt gccttcgcac caggcaattc aatcatcggc gggctggagt 3438841 gggcaggcct caaaggggtc ggatttgatc cgggagatta cagcgatacc atcccccact 3438901 cgttatttat gatgttccaa atgacgttcg ccgttctgac tacagcgatt atttccgggg 3438961 ctttcgcaga gcggatgcga ttcggcgctt ttcttttatt ctcggtttta tgggcctctt 3439021 tggtttacac acccgtagcg cactgggtat ggggcggcgg ctggatcggc cagcttggag 3439081 cgctcgattt cgctggcggc aatgttgttc atatttcctc cggggtggca ggacttgttc 3439141 ttgccattgt gctcggcaaa cggaaagacg gtacagcgtc ttctccgcat aacctcattt 3439201 acaccttctt aggaggagct ttgatttggt tcggctggtt cggctttaac gtcggcagcg 3439261 cattgacctt agatggtgtg gccatgtacg cgttcatcaa cacaaacacc gcggctgcag 3439321 ccgggatcgc cggctggatc ttagtagaat ggatcattaa caaaaaaccg acaatgctcg 3439381 gagcggtatc tggggcaatc gccgggcttg tcgccattac gccggctgcc ggatttgtca 3439441 caccgttcgc ttccattatt atcggcatca tcggcggagc tgtttgtttc tggggagtat 3439501 tctcgcttaa aaagaaattc ggatacgacg acgcgcttga cgcctttggc ctgcacggga 3439561 tcggcggcac atggggcgga atcgcaacag gattattcgc aacaacctct gttaactcag 3439621 cgggcgcaga tgggttattt tacggtgatg caagcttaat ctggaaacaa atcgtcgcca 3439681 tcgccgccac ttatgttttt gtatttattg tcactttcgt tattattaaa attgtaagcc 3439741 tcttccttcc ccttcgcgca actgaagaag aagagtcact tgggcttgac ttaacgatgc 3439801 acggggaaaa agcatatcaa gattctatgt gaggagtgac gctatgagcg gtcaaatgtt 3439861 caaggtagaa attgtaacgc gtccggcaaa ttttgaaaag ctgaagcagg aactcggaaa 3439921 aatcggagtg acctctctga ctttctccaa tgtacacggc tgcggccttc aaaaagcaca 3439981 tacggagctc tatcgagggg taaaaataga aagcaatgta tacgagcgtt taaaaataga 3440041 aattgtggtc agcaaggttc ctgttgatca agtgacagag accgctaaaa gggtgctgaa 3440101 aacgggatca ccaggtgacg gtaaaatatt tgtctatgaa atcagcaata cgatcaacat 3440161 ccgcacaggc gaagaaggac ctgaagcact ttaatatcgg tacgagattc ggacactccg 3440221 gatctctttt tttgtgcaca gaatcccccc agaaaccgcg attcctcttc gaattctctt 3440281 caagcgccgt tatttcagac aatctctatt tttatttgaa acttttcatg agtaagatta 3440341 gtctactaaa tataaaaatg taaaaggtga ttatttgaac tacgaaattt ttaaagcaat 3440401 ccatggacta tctcatcaca attcagttct cgattccatt atggtcttca tcacggaata 3440461 tgccattgtc gcctatgccc ttatcctatt ggcaatctgg ctgtttggga acacacaaag 3440521 cagaaaacat gtgctatacg caggcatcac aggaattgca ggccttgtga tcaactattt 3440581 gattacgctt gtttatttcg aaccgcgccc gttcgttgcg catacagtgc atacactgat 3440641 tccgcatgct gcggatgctt catttccaag tgaccatacg acaggtgcat tagcgatttc 3440701 tattgcgatg cttttcagaa accgcaaaat cggctggccg cttgtcattt ttgggctttt 3440761 gacaggcttt tcgagaattt gggtgggaca tcactatccg gtagatgtat tgggcagcct 3440821 cgttgtcgcc atcattatcg ggttcctttt ctttagattt tcagatctgc ttcgcccgtt 3440881 cgtcgatttg gtcgtgagga tctacgaagc cattatcaat aaactgacga aaaaaccaac 3440941 cgatcaaaat ttctaagaaa gacaaaagcc ggcgtctgaa atcaagacag ccggctttaa 3441001 tatttctcat acatctcttg ttttcttcgc ttcgccaaca catataaacc ataaaacaac 3441061 ccaattccaa cagcatcgat gagcacatcc cggatacaac cattcctgct gaagaagagc 3441121 tgaagaactt ctgtgaaaaa agcaaacgca aatgagccgg ctgcagctga tcttatgctg 3441181 ccccgctgtt tccacagcaa atatgtcagc acaaagaagg aaaacgcgtg tccgattttt 3441241 tgaataaacg cttcaggtac agtaagctca gtaaaatcca taactaaaaa ttgagacaga 3441301 tcagggtgcg gctgaaaatg aaaagccacc gtttgcgata cgaccatgcc gctgaagctt 3441361 tccgtacaga cagaaagcag gataaaaaag atccagcctg cgagcaatag gcggttcatg 3441421 acataacctc ctttataacg tacgtgccta catgtaacta catagacggt aaaacaaagc 3441481 aaaaagtaac agaaaaaaac gcccatcaca aggatagacg ttttcttcat taagactgtt 3441541 cagtgtcttc tgttgtgctg ctttctttag aaccagattt gtcagttgaa tcatcctttt 3441601 tctcaccgga tttttcttct gttccttttt cagttgatcc gtcctttttc tcggaagatt 3441661 gctgaatgga ttcttctgtt tcttgggtgg cagctttttc aatagaagaa actggtttgt 3441721 ccataaagtt taacggattc attgcaaccc catctttacg gatttcaaag tgcacgtggt 3441781 ttccgctgtc ttcactgtaa aggttcttgc cagattttcc gatcacttga ttttgtttta 3441841 ctttgtcacc ttgctctacg cttacttcgg aaagagattg atacacagtc gataaaccgt 3441901 cggcatgttc tacttccaca acatatccca gcactggatc tttttcagct ttaacaaccg 3441961 taccgctcag agaagcagag acatcgaaat cttttccgtc tttctcagct aagtcaattc 3442021 ctttgcttag gctgtacgtg ttattatagg taacgagtgc tgcttctttc tcttcttttg 3442081 cggcatcggt ttcatagaac tttttcacaa cagaaacgtt ttcagaatca acaaccggca 3442141 ttgcgacatt ttccattgac tttcctactt caactgcatc gtcgttgttg tcatatgcgg 3442201 agtttccgcc gttatcagcc aactgatcct ttacctcatc atttgatact gattgatacc 3442261 aaaggacagc tgttaaaatg acggccgcac tgactaagta aattgcaggg aacacccagc 3442321 gtttacgaaa aaactgctga agttttttga cttgagaagt tttcttttct tcctctctca 3442381 ttgtttcatc acctcagcaa cattctgaac acttttctga aaatatatac aacctatcca 3442441 aaaaaacttt tttagatgta gtttgcacag actgaacgaa aatatgtatt tttttgagag 3442501 gagtgccaaa aacgtatgaa catgacattg cgtcttgctg aacatagaga cttggaggct 3442561 gttgtggcga tttataattc aacgattgct tctcgaatgg taacagccga taccgaaccg 3442621 gtaactcctg aagaccggat ggaatggttt tcgggacata cagagtcacg tccgctctat 3442681 gtggccgagg atgaaaacgg aaacgtcgct gcctggatca gctttgaaac attttatgga 3442741 aggccagcct ataataaaac agcggaagtc agcatataca ttgacgaagc atgccgcggc 3442801 aaaggtgttg gatcatattt gcttcaagaa gcgctccgca ttgccccgaa tcttggcatc 3442861 cgctcactta tggccttcat tttcgggcat aataaaccaa gcctgaagct gtttgaaaag 3442921 cacgggtttg cagaatgggg actattcccc ggcatcgccg aaatggacgg gaaaagatac 3442981 gatttaaaaa ttttagggag agagctttca tgattagtct ggataaagat gaaaacgaaa 3443041 ttgaacatca taatgaagaa aatagccttg ttgaacagga gactgcacct gttggacagg 3443101 agagccgcca gctgagcgcc tccgctgtca agtcgctatc cgacattgcc aagtggggca 3443161 aaatttctgg catcttgtta atcattatgg gatcgcttgt cactctgtct gttttgatga 3443221 cagtgattgg cgccatcccg ggcgtactgc tcattatttc aggcgtattt ttgatgcgct 3443281 cagcaaaagc agccgcggaa gccgaaggaa atctaaccgg cagcgctggc gaaagcatgc 3443341 ttgaaaatta cgggacattt ataaaaatgc agctgtttta tgcagcatcc agtatcgtta 3443401 ctgtcctgat cgggatcatt gtagccattt tcgtgctggt ggtaatcggc attgctgctt 3443461 ttgagaacac gccttcgtat gatgatccgg attcttatta ttatgaggat gatccggtgt 3443521 ttgaataatg atgagacagg acagggcatg agttccatat aaacggaacc atgcctattt 3443581 tatttgacta ttcaaagcag gccggcgtaa acaccaaatc ctgaagcaag catacaatag 3443641 acatctctag tagaggaaat caacaaagca acgctgttac ccagaaatga atatcaaaaa 3443701 aacggatgaa gtcggaatca atccgaaacc gcacttttta tttcgggtgt ctgcatgcaa 3443761 aaaaacacac ccggatcgtc tggaaaatct caacaatccg ggtgcagatc ttctttaata 3443821 catttttttg cgtctgtctt cctcagtcaa aaattcaaca aaactccgca tcgcaaaagg 3443881 ctcttccttt atttgtcgtg cgtaggagct tttccgctct tctgaaagga tttcgctctt 3443941 tttgatcctg ttcagcatat agatgtgaac cgttttttgg atttgtttat gctgatagcc 3444001 tgcctcttta aaaaatgcga gcccgagcgc cgccaaaagg gcgaatatgc ctgcgctgat 3444061 cagggactcc ctgtcagctg aagcatgaaa tagaaaagca gctaaattaa agagagagaa 3444121 tgcagcaagc ggaatagcaa gaaaacggta aatgacggtt tttttcatga aaggctgtac 3444181 ggccttttga attttttgca tttctgtttt gatgaacccc ggcatttgtt cgactctgta 3444241 aaagttcata taatcctccc cctttatttg atgtttcaag cttcacgaac gttatcatat 3444301 gtgtttattt taacgcaggt gcaagctggt tttaaagaaa tctgcccgta tttttcacga 3444361 agaatctgga tcgccgctct ttattctttt aaaatgtgag tgttataatt tgtaatggga 3444421 atcagatcac tgttattcat ggaatactaa tggcaatctt cttgataaat atgaatgagc 3444481 ggggttacaa agtgagtatt tcttccatcc ttttatcact ttttttcatt ttaaatattc 3444541 ttttggccat cattgtcatc ttcaaagaac ggcgcgatgc cagtgcatct tgggcgtggc 3444601 tgcttgttct tttctttatt cccgttttag gctttatttt atacttatta ttcggccata 3444661 atctcagacg caagcatttg tttcaatggg aagaccggaa aaagattgga attgaaaggc 3444721 tgctgaagca tcagcttgaa gatttagaaa ccaagcaatt tcagtttaac aaccgggcaa 3444781 cctttgataa caaagattta atttatatgc tgattatgaa taaccatgct gtgtttacag 3444841 aggataattc agttgacgtc attacagatg gacgggataa atttcagcgg ctgctgagtg 3444901 acatttcaaa ggctaaggat catatccatt tacagtatta tatttataaa ggcgatgaat 3444961 taggcaaaaa attgcgggac gctctcatcc aaaaggcgaa agaaggtgtt caggtcagag 3445021 tgctttatga tgaactcggg tccagaacgc tgagaaaaaa gttttttaaa gagcttcgcg 3445081 aggctggcgg gcatgtggag gtctttttcc cgtcaaagct caggccgatt aacctgcggc 3445141 tgaattaccg gaaccatcga aagcttgtga tcatagacgg tatgaccggt tatgtcggag 3445201 gctttaacgt cggagatgag tatctagggc ttaatccgaa attcggttat tggcgggata 3445261 cgcatatccg gctgcaagga acggccgtgc acgccatcca aacacgattc atccttgact 3445321 ggaaccaagc ttctcatcac catacgctga catatattcc aaatcacttt cctgattacg 3445381 gcccaaaagg caacgtcggg atgcagattg tcacaagcgg ccctgattcg gaatgggaac 3445441 aaattaaaaa tggctacatc aaaatgattt cgaacgccaa gcgttccatt ttgatacaaa 3445501 caccttattt tatcccagat gcaagcctgc tggatgcttt aaggatcgct tgcctttcgg 3445561 gcattgacgt taacattatg attccgaaca agcccgatca cgcctttgta tactgggcga 3445621 cactttcgta tatcggcgat ctgctgaaag ccggagccac tgtctatatt tacgataacg 3445681 gctttattca cgcgaaaacc atcgtggtgg atgacgaaat cgcttcagtc ggcacagcga 3445741 acattgatgt ccgaagcttc aggctgaatt ttgaggttaa tgcatttatt tacgatatca 3445801 ccattgctaa aaaactggtt tcaactttta aagaagattt gctagtatcc agaaaattca 3445861 cctatgagga gtatctgcag cgcccgttgt ggattcgaat aaaagaatcc gtctcgcggc 3445921 tgttgtcgcc gatcttataa gatgcgtaaa cccccggcct ttacggccgg gggttttcct 3445981 gatggtcaca gtaaatgatg attgcctccc gcaaaaaagc ggcaagacct tctccatatt 3446041 gattgattga atcggtaaat cgctcgtcag tgatatacac ttccccgagt cctctgaaaa 3446101 tgtcgagtgt gcaatcgtaa tgatattggc aaatatgatc gcgaaatgcc cccacagcgg 3446161 cctgaatctc tgcatcatcg ggcccatgct tcattcgcgc cgcaattcgt ctgtaaatcg 3446221 aatcaaattc agccatgatc gtgcgccaat catctgccga gtatgcagat gtccttttct 3446281 ctgtttcttc tgcgatttcc tttccataca gctttctgac ttcatcagcg tatgtctgct 3446341 ggtgctcttc aatgtctttc atgcttaatc cggcaaataa atccctctta ttcatcgttt 3446401 cccctccatc aacggacaaa agcgtcctgt caattgtttg aatcatctca tccattcttt 3446461 gttttttctt catcaatatc tccttttgcg actgaagtgc cgctttccgg tcaaaattcg 3446521 gatgatccag catctcttta atctcatcca gacgaaaccc gatttccttg aaaaataaaa 3446581 tctgttgcag tctttccagg tctgcgtcac tgtacaaacg atacccagca tcagtaagcg 3446641 ctgaaggatt cagaagctca atattgtcat agtgatgaag cgtccgaatg ctaacgcctg 3446701 atatctccgc cacttgttta acttgatatt tcatacataa cacctcctct tttttatcgt 3446761 aaacaatcac gcaacgttag ggtcaatccc caaaatgtta ttttctatat acaaaacttc 3446821 tcacaaatag tgtataaaag aaaagtgagt atttttttgt aaaggggagc cagtatacat 3446881 gaatcctgaa acaatgaaca aaaccctcat cagcatttcg aaatggggaa aagctacagg 3446941 cattttattt attattatgg gcgcaattac cgcgctttca ggcgcgttct tttttctaat 3447001 cggtgccgtg ccaggcgtac tgcaaattat ttccggtatc tttttgatga ggtcagctag 3447061 ggaagcaggc caaatggctg aacacaatag cggacagtct gaagacttaa tgctggagaa 3447121 ttacgcgaaa ttcgtaaaga tgcaagggat ttatttgatc gtaagcattg ctgtatccat 3447181 tcttgcgatt atcgccttct tcatcttttt aatgcttggg attgctgacg gccttttcag 3447241 cgatacgtac agcacttatt aatgagaaaa acccggagct ggctccgggt tttttattat 3447301 tccgcttcgc ttaccactgt gaagcgttca tttttgtgtt cgggatgttc aagctcgtcc 3447361 aacacggcaa tggcataatc tgcatagctg atatagctgt ctccttttgc atttacgatg 3447421 acattgtctt ttcctttttg gtaagagcca gtccgttttc ctgctggatc aaaaaatgcc 3447481 gcaggactga ggaacgtcca ggaaatggag tctgtctgct gcaaatcttt caggttctcg 3447541 ccttgatttg atgcagttgg caaatattct ttcggaaatt ccggcgtatc cattaaacgg 3447601 gttgttttgg cttcatcaac aaacaggctt cccgctccgc caacaacaag caatcttgtg 3447661 tgcttcgcgt cctttaaaat gctgatgagt gctcttcctg cttcaacatg aagatgttct 3447721 tggccgggtg ctgctccaaa agcgtttacg accgcgtcga aaggcttgat gtcttccgca 3447781 gtcagttcaa acacatcttt ttccaaaatc gctacgtctt gctcctgcac ttttgaagcg 3447841 tttctgacga tggctgtcac ttcatggcct ctttttttcg cttctttcaa aatctcgttt 3447901 cccgctttcc cgcttgcgcc tataatacca attttcattt ttcatttcct ccttatttgt 3447961 aacaatttta gttacatgtt agcggtgaga agtcatccct tttgattaaa agagatgatt 3448021 cataacatct tttaatgact tgcttgccag ttcattttcc atcgctcttt gcacactttc 3448081 aaacgtttca tccagagcgt tctgaatttt tttccctacc ggacatttcg gattcgggtt 3448141 ttcatgaacc gcaaagagtt cttcttgctt ttggacagcc cggtacactt ctaaaagaga 3448201 aatatcagca ggatcttttt tgaggcttgc acccggcacc ccggcgcgtg atgtgagaat 3448261 atcagctttt ttcagcaggc tgatcattct tcgcacaact accggattcg tgttgacact 3448321 gtctgcaatg atttctgaag atgttttttc atccatcgag atgagggata aaatatgaat 3448381 ggcaacagca agacggctgt taatcatgtt ttttcaccac cgttgtaact ataatagtta 3448441 catttgattc gtttgtcaac atctaatata cactaaatac atgggttttg tgcaccgttt 3448501 ttagtcaata gaacggccgg atgcactccg gccgcgtctt atcaaaataa gaaatatctt 3448561 tgtccaagtg ggacataatc gacaggctgg caagacaatt cctccccgtc agcaaagacc 3448621 tgataggttt ttggatcaat ctcaatcttc ggcaaagccg aattcagctt catatccagc 3448681 ttgctcagct ttctgatatt tttgactgga gaaatccttt tttccagccc taagctttcc 3448741 gccacaccac gctctatgct tgcctgagac ataaatgtaa tcgaggttga gcggttggct 3448801 tttccgtaag acgcatacat ttggcgcatg aaaaccggtt caggagtcgg gatggacgcg 3448861 ttcggatctc ccatttgcgc acgtgcaatc atgccgccct ttaagaccag ttccggtttc 3448921 acgccgaaaa ataccgggtc ccacagaacg agatcagcaa gcttcccttt ttccaccgag 3448981 ccgacctcat ggctgagccc gtgcgtaatt gccggattaa tcgtgtattt ggcaatgtac 3449041 cgttttgcgc gcacattgtc attcccgttt tcaccggcaa gagcgccgcg ctgttttttc 3449101 attttatcgg ctacctgcca tgttcggatg atcacttcac cgacccgccc catcgcttgg 3449161 gaatccgatg atgtcatgct gatcgcacct atatcatgga gaatatcctc cgcggcaatc 3449221 gtcgccgccc tgattctgga atggctgaat gccacatctt caggcacttt cgcatctaaa 3449281 tggtggcaga ccatcatcat gtcaagatgc tcatccatcg tattaacggt ataaggaatg 3449341 gttggcgttg tagatgacgg cagaatgttc gcgtaagagg cgagcttcat aatatccgga 3449401 gcgtgaccgc cgcctgcccc ttcaatgtga taagtatgaa taacccggtc cccgatcgcg 3449461 tcgagcgtgt tttccaaaaa gcccgcttcg ttaatcgtat cggtatggat ggcaacttga 3449521 atatcagcct cgtccacgac ttccatacac gttttaatgg cgcttggcgt cgttccccag 3449581 tcttcatgga gcttaagacc gatggcgcct gcttccacct gctcgatcag cggcgcttta 3449641 tcggatgcat tcccttttcc taagaagccg acattgatcg gaaactcctc ggccgcttcc 3449701 agcatcctcg ccatatacca cgccccggac gtacatgttg tcgctttgct tcctgtagcg 3449761 ggtcctgttc cgcctcccaa aagggtcgtc acacctgaag aaagcgcaac ttccatctgc 3449821 tgaggacaaa taaaatgaat gtgcgtgtcc actcccccgg ctgttaaaat tttgccttca 3449881 ccggaaatca cctctgtccc cgctccgatg accatgtgcg gatcgactcc atccatgata 3449941 tcaggatttc cgctttttcc gacaccgaca atccggccgt ctttcacacc gacatccgct 3450001 ttgacaatgc ctgtgtaatc caatagcacg acgttggtga taaccaaatc caaagcgccg 3450061 tccttccctg tgattctgcc gttttggccc atgccgtctc ggatagtttt tccgccgcca 3450121 aagatcattt cttcaccgta tactgtgaaa tccttttcga cttcgatcca taaatccgtg 3450181 tcgcccaatc tgattttatc gcccgttgtc gggccaaaca gttccgcata ttcctcccgt 3450241 gacattttca tcggattaca ccctccatcc agccggcttg ttttaagttg gccaacgttt 3450301 tttctttgcc gcgttcatcg ataaacgtgt cggccattcc gttcagccct ctaattgtct 3450361 tgcgtcctct gatttccact agtgagaccg ttttctgctc tcccggctca aaacggaccg 3450421 acgtgcctga tggaacatca agacgcatgc cgatcgccag ctcacggtca aataataaag 3450481 ccccgttggc ctccgcaaaa tgaaaatgcg aaccgacttg aatggagcgt gatccggtgt 3450541 tttttaccgt tacctcccgt atctcacggc cttcattaat cgtaatggtt ccctcagcaa 3450601 tttgaaatgc tcccggcttc atgacttcac ctccgcagaa attggctgat gtaccgtaac 3450661 aagctttaca ccatccggaa atgtggcctc cacctgaatg ctgtccagca tctcaggcac 3450721 accctccatc acatcttttt ccgttaatac atggcggccg gcttccatca gctctgctac 3450781 tcccttccca tcacgtgcgc cttccataat aaagcaggtg atataagcag cagcctcagg 3450841 atagttcagc agaacgcccc gcgcctttcg ctgtttggct aattcccccg ctgcaaaaat 3450901 gagcaatttc tcttgttcaa ctggtgtcag tttcatctgt agtcctcctt cttttgtcat 3450961 ataaagcaga tgcggctact acgaatttgc ggaacagtca ggcgggacat cacctccctt 3451021 tcttcgagaa tgggggtcat acggtaagat gcctttcaaa gcggcatgcc gtttcttcat 3451081 cagccttgcc atggtcaaca accgttcccc tgtcgatcac ggaaagatca gattaacgcg 3451141 ttttccagac tgcgctcgac taagataaca aatgtctttt tttctggaaa tttctataat 3451201 aacttgtctg actagttcga caattaaaat ctgaattcct tccaattgtt tattaagtaa 3451261 aatatttttc agatttacca tcagcgctct ggtgattgca agctgctgct gttgaccgcc 3451321 ttttcgtttt gaacaaacgt ttgattaaaa caaatagccc cctctgttta gccggagtcg 3451381 gcctaataca gcgacaatct gccccgggcg aagctaaggc tgtgcaaaac catcgattga 3451441 tcataaccag acgttacatt cctgatggca gcccgttgtt ttgctccgca accggaagca 3451501 tggcatggag gccagtctga ggcgccgacc tccacgatac cgagaacccg actattgcca 3451561 ttaactccgc atcatggacg gtcacttcgc tgatcgccac cgttcctctt aatgagtgaa 3451621 gaattccggc cttcactgaa tccccgcttg tgtcgatatc aactgttttc tcgcactccc 3451681 gtggcttccg acactttctt cggtgcagta cattccgtca tcaaaacccc tttgtttgat 3451741 ttcttcaaat gatgttataa aagtttacaa cttatgtcat cattatatag aagaggccta 3451801 ttaattcaaa gaatatttaa aaaatttagt taccttgacc aaatcagctt ctttttttgt 3451861 tatatttatt cacatcagaa aaagcgaaaa aaaagacaag aaacatttcg tttcctgcct 3451921 cttccgtacg attaatcttt atctgaaaat ttatccttgg ctttcccgat atccttttgg 3451981 atttcgcctt ttgccttatc ttttttgcct tcagcctgca tgtccgttct gtcagccata 3452041 tctccgactt tatccttcac ttctcctttg gctttattga agccgccctt cattttgtct 3452101 tttacactat cgttacccat gttaattctc ccctctcaat tatgtgtgta cttgttaact 3452161 tcccgatctg agaggcaata aacattctaa tgttatttat cgatttcgta gcgctctccg 3452221 taacggagca ccttgtatat cgccagcccg tctgatgact ttttctccga atatcggacc 3452281 ggcagcaggg caaaaaacac ataatacgta gaaaaataga caaactgata gaaaaacaca 3452341 ttcggcttta atacactgtg tataatcagc agattgattg caaaaatcgt gatgaggtta 3452401 aacaagcagc cccctgcata cacgagtgca tttgagaatc gattgtcaat tttcaactcc 3452461 ccgtaccggc aaaaagaatc gataaaataa atcgttctga accgtatggg tccaatttta 3452521 agcagcgttt ttcccatgcc tatatccaac gatccctttc cgccaaaaat aaaagccata 3452581 aagctgtgcc ctgaaacatg tataatctgt acaagcggca gaacaatgag gaaagaccac 3452641 agaaacttca ccatatcatt aaaaccaaac attgaattcc ccctcacatg catatctgca 3452701 tcccaaaacg gcttttgttc aaaaaacagt gctgtagcga tttttcctgt tctccccgga 3452761 aataaacgtt ccgatgctcc cctttttttg cataaaaaaa aaccatctgc cagcagatgg 3452821 ttttgtctca tacttcatat aaacaatcgt tcctttgaat catctctctc atgctgaccg 3452881 ctttttcata aaaatacacc gcttctttat attgttcgcg atgactgaaa taagaggcag 3452941 catctaaagc aaattcttca atatatacat acaggccctt ttcttccata taatcaaata 3453001 cttcttgaat catattcaaa ttgacagatt ccacatataa tgcctgcaga aatttatatt 3453061 ttgccagact gaagaagtcg tttcgttttt gggcaatggc aatccctttt tcatagtacc 3453121 gtatcgcggc ttcgctatct tgttttttga aaagaacgcg agtcaggctg aagagcgctt 3453181 ttggaagctg ttccagctga taatcctcga agacaggaag cgctttttca aagtattcgg 3453241 cggcctgatc cagctccccc ttgtcatcat agcaattacc aatattataa agggctgatc 3453301 cgatcaaacg gggctgtcct tccaataaag caaggcgata cgcgtcatct aaatgttcaa 3453361 gcgctttttc ataatttctg tagtcaatgt agtttcctga tatgacgaaa tggcattgaa 3453421 ttcttctgac tctgtaaaaa tcgtgagcct tatacgtctc cagcgcctgt acggcatggt 3453481 tcatggaaaa gtgcgtctgc ttcataatat aaaagacttc cgccacttta aaatgaaatt 3453541 ccgctctttc aatttcatct tctacaaacg caagcatctt ctcagctttc cgataaaagg 3453601 atatagccga gatgtaattg ttctgttcaa attcgtacat tcctctaaac aagtgaaaat 3453661 aatactcaga taatccggag atgctgtcct gattgctttc cagcgttttg atcaattcac 3453721 gatattgaag ctgagattcc tcgtgcaggt caggctttac ataatccagc ataatttggt 3453781 gccggtagct gatcagctga taatacagga gaagcagctg atcctcttcc atctgttcga 3453841 tatctagatc aatttcttct ttcagtttta cggcatcagc cacttgaaat gctaaaatgt 3453901 gcttatacca cttattgatt ttcactccta cttgagatga cgggatctcg tacgcggcca 3453961 tgcccctcca accctttcta ttttctaatt ggttatattt tatcataatg tatggctttg 3454021 gaattaaatt ttcttacaat gattccttct ttatgcctat ccttatatat ttcggttttt 3454081 ctacgtattt tttgcactcg gattctaata aaaaagctta ccggacagtg ccgataagct 3454141 tttgacttca aattaaccgc caatataaga catttccact ttctttttgc cagatgcttt 3454201 tgatagcgta cgatcgactg aatactgatc gatccgattt ttccatactg tcccgatcat 3454261 ttctgatagt tcgtcatcac ttaattcctg gcgaaccgga gctctgaggt caaatccgct 3454321 tgaagcgaat aagcaggtaa acagctctcc tctcgcagaa agacgggctc tgttgcaaga 3454381 tccgcagaat gcatcagata cagatgatat gacgccaatt tctccggagc cgtccaagta 3454441 gcggaatctg gaagccactt cgcctatata attaggcgct atcggctcaa ccggcatgtg 3454501 tttattgatc aaatctatga tttccgcctt tgtcatgacg tctttctttt cccattggtt 3454561 ggtgttgcct acgtccataa attcaatgaa tctcaggata tgcccttttt ctttaaaata 3454621 acgggccata ggcagtatat ctttttcatt gacgcccttt tgaacgacca tattgatttt 3454681 aacaccgagc cccgcttgct tcgccgcttc aatgccttcc agcaccttgc tgacagaaac 3454741 accgcgcccg tttatcttct taaaacgctc gtcttctaaa gaatcaaggc tgatcgtaac 3454801 ccttttcagc ccagcctcct tgagcctctt agcataaaca ggcagcagtg atccgtttgt 3454861 cgtcatcgcg atgtcacgaa tacccggtat gcgggccagt tttttgatta attccggcat 3454921 atcctttctc atgaggggct ctccgccggt caagcggatt ttttcaacgc caaatcttgt 3454981 gacaaacaat gtcgcaagcc gttccagctc ctcaaatgaa agcagctcct ctttctttaa 3455041 aaaaggataa tccgggccga ataattcggc gggcatacag tacgtgcatc ggaagttgca 3455101 gcggtctgta acagaaatgc gaaggtctct cagcggtctg tttcttttat ccaacatctg 3455161 acgcgactct gtaatcatag ctacagcccc ttcctactcc ctgattctct cagggtgtgt 3455221 atatacatta aatgatccgt ttctgacaaa tccaatcgct gtgatattca attcttcagc 3455281 catttgaatc gcaagctccg tcggggccga tttggaaatg acaatcgaca cgccgatttt 3455341 ggccgctttt aacaggacct ctgatgagat tctgccgctg aacacaatca gtttgtcgcg 3455401 tacggacatc ccgtttagaa ggcagtgtcc gtatagttta tcaagtgcgt tgtgccgacc 3455461 gatatctgtg cgcatcaaca gaagcttctc tgtgtcgcaa agcgccgcat tatggacgcc 3455521 tcccgtatcc tgaaacgtcc cgctcccttg ctgcatgtct ttcataagcg ccagacatgc 3455581 ctcaggcgat atcttgattt ggctgacagc cgtcttggct gttttgacat cctgctgaaa 3455641 ataaaaatga cggccctttc cgcagcatga gccgatcacc cgtttcgtat aatccttttg 3455701 atccaatgtc tcagggtgaa cgaggtcgac atatacaaaa ccgagacttt catctattgt 3455761 aaacctttta atttcttttt gaaatcgtat aacaccctct gatgcgagaa atccgatgac 3455821 aagctcttcg atatgctcag gcgtacaaac gagcgtcaca aattcactgc cattcagtat 3455881 cactgtcaaa gggaattccg tcaccatccg gtcttctact ttgcttattt ccccttgttc 3455941 atagcgccat acatccctga ccgcagttac tttatcgttc aatgtctctt cccctccgca 3456001 atgttcctgc ctttatattt tttcacactc ctcggatttt gtcgaattct gagacacaaa 3456061 aagagccctc tatataaagg gcttttacag gatgtgatga cggcggtgtt taggcaggac 3456121 gcctaagcat ttagccgccg ttccttttat aacacgtgag caccaatgtg cattgacaac 3456181 gaacgcgggg tttgtcgaca cgctgagaca cctctgtata aaggactcta tgtttgatta 3456241 tgctgattct ttttcagaac cgtaaacagc acaatagctg cgatcaaggt gagaatgctg 3456301 acaaaaaaga aggctgccag ttttagaaga acaccaagca atataaatgc aacggtggct 3456361 ataagaaaaa tcattccgaa taatttcata tgttcaaccc ctttttaggg tatcattccc 3456421 gcccaaactg tttttaaacc aataaaaaag gcgcctgggg gagcgcctga tctttaggtt 3456481 ccttactcag taaatttttg tgcttctttt tcccaagcct gttcgaactc atccgcactg 3456541 ttcgctgaaa tatattctcc gccgccagcg acagctgctt gtttcatctc ttcattaccc 3456601 ttgacatcaa agttgaagcc aatgatgttt acaatcgtat ccacatttga tgcacggagc 3456661 ttttcgattt ccgccgcagg gtctccgccg cacgtttctt caccgtcagt gattaaatac 3456721 accacgtttt tcccgtctgc gtcaaatgct tcaaattctt ttcttgtgtc tgcaagtgct 3456781 ttggcaatcg gtgtccatcc agtcggcttg agctcactca atgaattgtc aaacagagac 3456841 ccttcatatg gatgaaggcc gtaaatggtt tccgtcgtac tgcacgaaag ggctttaccg 3456901 gacagtttat tgttccctgc atgcccgaaa acgcgaagca taagatttgt atcctttgga 3456961 agaagttcgg caaaagattt tactgatttt ttggcaatgt ctattttgcg ctctcctcct 3457021 gttttttgaa ccatgcttcc gcttccgtca aacaaaacag ctacatttgt atcagcctgt 3457081 ttctcagcgg caaaagacgg ggaggcaatg gaaacagtca acaatccaat gataccggca 3457141 gccagcaatt ttttcatatg attacttcct ttctttttca tattttccaa ctatatgttg 3457201 gattcttctt tatgctagaa tacgaaaatg caaaaagata taggacatgc tgccttttgt 3457261 gctgctttca cgatctgtcc aaaatcgctt gaaatgccgt tcatttttag ccatttccgc 3457321 ccagaaagca taaacagctt gtgtgatcat tcattctttt ttcgccttga ttatgacaga 3457381 aaaacggaaa tctgctacta tgctacaggc agacagctaa ttagttttga agtttttgtt 3457441 acatacaaaa agaggctgac catcaccagc ctcttttttc ttatttagat aacattagtg 3457501 attgctgagt gaaaattttc tcaacatctt tttgggtata agccgggaag tattcaccgc 3457561 cgcctacttt cgcaattgcg ttcagctggc ctttgtatcc ctctttataa tcaaagccga 3457621 tcacattaac agtgatattg tctttttgca gttcctttgc tgttttaatc gggtttcctc 3457681 cgcacgtttc ctcaccgtct gtcaacagat acaccacttt ttcccctttt gcatcaagct 3457741 ggtcaaaaga agatttcgcc tcgttcagcg ctttggcaat tggcgtccag ccagtcggcc 3457801 caattgtatt gagagaattg aggaagcttt gctcgttaaa gctttggaag ccgtatacgt 3457861 tgcgaatggc ttcacatgac tgaacttttc cggaattttt attgtttcct tcagagccaa 3457921 acacgctcat tttcacctga gttccttctg gcaatgagct cgcaaacttt gaaatttctt 3457981 ttttggctga attaaattta gatacaccat ctattctttt cgccatactt ccgctggcat 3458041 caagcaagac cgccacgttc gccggcgctt tagcctccgt ttctgtcttt tcagctgcaa 3458101 aagcaggtga agttaatcca aaaagcaatc ctgtcatcat gatcagtgaa aatcttttct 3458161 tcatgttcgt acccctttac caatttgttt ctgcgtgcag atgttcaacg ctgaacataa 3458221 tctatcgtaa tcaacaaaaa ccgagaaata aatagggcgg gcttccccat tgctgttgtt 3458281 tacttttgca tagaaaccta tgtttttatt agtgatttcc acctaacgcc cctatgaaaa 3458341 gagaagattg tccgcctttc ggctttcgtt atatgagtct gtcgaagtct gtcgacaaat 3458401 gtggatgact ttaccacaat ctcaaagcct gaaatcagga aaaaaggact gatccttaaa 3458461 gacggtcaga agctcctcta aaccgtttca gctactctta gataaaagat attcaggaac 3458521 agaaaaagac gcccaatgag cgtctttttc tactttttcg ccatatattt attcaaaaac 3458581 gcatctgcct cagaaatttg tgtgccttgg taatagtact ttacaatgtc atcaaccgtt 3458641 ttgccttctt tggccataaa attcgctccg tattggctca tccccacacc gtggccaaat 3458701 cctctcgtcg tgactgtaat tgtgtctcca tttcgcttcc attcaaaatc ggcggagttg 3458761 agacccaact tttcacgtat gtctcttcct ttcagcgtct tgccgttaat gacggcagtt 3458821 gcgacctggt ggcccggtgt ctcgccggta atcttcccta ctgcgctaga tccatccagc 3458881 ttgacgccaa gcttttgctg aaattctgcc gctgtaaagg ttttcgttgc cttatatttc 3458941 ggagactttt tatcccatgg gcttttgacg ctttttaaat atgggatagc acttgtccaa 3459001 taagcttctg cattctctgt gtagccgttg cttgtggaga aaaaggatgc ttcaatcggc 3459061 tggttgttgt acgttaagat tttgccttgc gtactggcta ccgcatctgt gattttcttc 3459121 agttttgtct catagcttgt gccccactgt tttttcagct ccgctttgct tttatacacc 3459181 tggaacatct gtgtatcatc caccagtgag cctttaggag cttctaccgc tgaatttgac 3459241 accatcagtc tgacaataaa tgttctggcg gcaagcgcct gggctttcag cgcttcaggt 3459301 ttaaaggttg ccggcatttc ggaggcgacg actccaatca catactcttc aagcggaatg 3459361 ttttctacgg attgatttgc ggttcgatag acgggaatag aaacaggtga tgctttcaat 3459421 gtttctgctc ctttcgatgc tggtttcgtg ctgactgctg tcttttctga ttctacgctg 3459481 gcccccgctt ccttattatg ctggaatggt ataaccaaga gtgtgggaac caagagaatc 3459541 aatgcacata gtacggatag tgtgattgcg aattgtttca tattcagctg cctcctgctc 3459601 gggattcgac tctagtctag tctatgggca gggacaagct aatatgactc tcgttttgga 3459661 cagaaacttt atttgtcatt tacgtattct tttttgctat tttgcgcata atgatgataa 3459721 tacacaaaaa ataaaaaacc agtatgccag agtgacatac tgattttcaa gtaagtttat 3459781 gcatttaagt cagaaacgac ttctttattc tcttgctcag aagcagactc atcatttaca 3459841 cgttcgatgt ctgcgcccag agcggcaagc ttctgatgga aatcaacgta accgcggtct 3459901 aagtgcttca attcagtaac acgtgtgtga ccttcagcca ctaaccccgc aagaatcagc 3459961 gctgcacctg cacgcaaatc agtcgctgca acttcagctc cctgaagctg tacaggaccg 3460021 ttaatgatga cagaacgtcc ttcaatcttg atatcaccat tcatacggcg gaattcttcc 3460081 gcatgcataa aacggttttc aaaaacggtt tctgtaatca tgcttgtgcc gcttgcacga 3460141 agcagaagcg ccatcatttg tgactgcata tcagtcggga agcccgggtg aggcattgtt 3460201 ttgatgtcaa tcggtttaag ctctttcggg ccgatgacac gcagaccttc accttcatcc 3460261 ttaattgtta cacccatctc ttccattttt gcaattaaag aggtgaggtg ctcaggaacc 3460321 gctcctttta ctaatacgtt tccttcagtg attgcagcag caaccataaa tgtgcccgct 3460381 tcaatacggt caggaataat atggtgtttt acgccgtgaa gcttttcgac tccttcaatt 3460441 ttgatggtgc cggtgccagc tccgcggatt tttccgccca tgccgttgat atagtttgct 3460501 aaatcaacga tttcgggttc ttttgccacg ttttccagcg ttgttgttcc ttcagctaga 3460561 gcggctgcca taatcaggtt ctctgtagct cctacacttg ggaagtccag ataaattttt 3460621 gcgccttgca gtcggccttt tacttcagct tcaatgaagc cattaccgac tttgatttct 3460681 gcgcccattg cttcaaaacc ttttaaatgc tgatcaatcg gtctggaacc aattgcgcat 3460741 ccgcccggaa gtgcaactct tgcatgacct gtacgcgcaa gaagcggccc catgacaagc 3460801 acagacgcac gcattttacg aacatattca aaaggtgctt cagtttgcaa agcgtatgaa 3460861 gcatttacag tcacttcatt attttcaaaa tgcacatctg ctcctaaatg acgcaacact 3460921 tcgttaattg tatatacatc ggagagcgta ggtacatcac aaattacgct tttttcttca 3460981 cttgctaata aagatgcagc gataacaggt aaaacggcat ttttagcgcc ttcaactttg 3461041 actgtgccgt ttaacttctg accgccgcgg acgatgattt tttccaaggt attcccctcc 3461101 gcgtccctaa attctctata ttaatattca gtcgtaacga ttggtgtgcc aaccgtaacg 3461161 gtatgttttc cgcccattcc tgcacttcta agtgcaattt gcaaattcat tttatgtttc 3461221 gaggtcataa tgtactcttc ccactcatct gtaaacgcag aaatagaaac gaaatttggc 3461281 tcaactacat gttctactga tcttgcttga aattcattta ataactgatt tgcttttttt 3461341 tgcaaaacaa tattcatatt atcatctaag tgaccattta gacaagtaaa aataactact 3461401 ttttcttgga atatcccaag tgtctcccgt tcaaactgtt catatgtatc attccagcta 3461461 tccggtgtct ctagactcat ttgctcatat aataaatacg aagttggatt gtgttttttg 3461521 agggttgtga caagctgcag tctaaaagaa gtacgatttt ttttgtcagt atatgtgcca 3461581 attgccttta tcattttatc ttcccgtgca atcacccaat catattgacg atactcttgt 3461641 tttaaacgtt gcactttttg ataaaattct ttttcggtca gtgacaagtt ttgttttgca 3461701 tgcaatgtcc acttatctat tgacacatct tgacgttcca tcccctctgc catctgtgct 3461761 aacggcgtta attcactcgc atgaatggta tggaaaacag caatgacgaa gcttaacatg 3461821 acggaaatga taatagcgtg gcttacttgt tttttcttca tgttcatctc tcccccttat 3461881 ccccagtttt accggaggca agaggcgcca tacgtaaaaa tcttcgtcaa aactcgagct 3461941 attcgcttca acccgcttct cccaaccatt taataatgtt caaaacctat taaaatagat 3462001 agggaagctg ctgtgaataa ttgaggtaat ctaaaaagaa attggcaacg gccgttccaa 3462061 tggcgattgt cagcaaaatc atcaggagtc ttgcctgcac gactttgcct tttttgatta 3462121 acggatctat attgacggct tgcaacgccc accaagtcac tgctataaaa atcaggtgaa 3462181 cgacaatgcc gattgcagcc tgctgtccca atacactcat ctattacact cctttctctg 3462241 cgttcatacc ctttcttatt atataagaag cacagataaa gatgatacat tttatacaga 3462301 acggaataat cagccaaatc tagggctaat ccccgcttaa agtgcgattc ttttacatgg 3462361 tatactttat tggaaaggag ctggcaaatg tgaatcattc tttttttcag cctgaaaagc 3462421 aatatggtga ggacctgcca atttttgatc aggaatggga agcaattgca ttctattatg 3462481 attatagaca gtcacagatt gaagaactga atgaattgtg tcagtttttt aacatttctc 3462541 ttacctatac gagagaaagc cttgaagagc ttgaaaacct ctattttcaa agtatacaag 3462601 aacttttgct tgctgattgg aatcttccta ttgaagaatt cgagaaaatg atcagtgttt 3462661 atcttataga ttgtgtgatt gcccgccatg aagatgctga atgggttgta aaaccttatc 3462721 cctataaaga cggcgcttat acacttggct ttagaagaca tcgcaaatcg tggcatacaa 3462781 tgaatgcctg tgatggttta tacctgcgtc caaaagagga tcgcccgttg ctgtcgctgt 3462841 ttgattctct tgtgcgttca taaaaaaatc cttctcataa agagaaggat tttttcttat 3462901 ttccctgcta catccaatct gttcaaagcc cgctgtaacg caagctcagc ccgacgaatg 3462961 tcagtatcat ctgattgaga attcaaacgc tcctgcgccc gctggcgtgc agcttcagcg 3463021 cgctctttat cgatgccttc cgctgtctcg gcagcctggg caaggatggt gacatgatca 3463081 ggacggactt ctacaaaacc gccgctgacg gcaaccattt cagtctgccc gtcttttttc 3463141 agacggacag cgccgatttt aagaggagcc acggttggaa tatggcctgg caaaataccg 3463201 agatcgccgc tttcggctct cacactcacc atttcgatat ccgcatcgta tactgggccg 3463261 tcgggagtaa cgatattgac tttaacggtc ttcatgcttt taccctccta ggaccagatt 3463321 aaacttctac acccatttct tttgctttct caacaacttc ttcgatacgg cctacaagac 3463381 ggaatgcatc ttctggaaga tggtcatatt taccggctaa gatttctttg aagccttgta 3463441 ccgtctcttt tacaggcacg taagaacctt tttgtccagt gaactgttca gccacgtgga 3463501 agttctgaga aaggaagaac tggatacgac gtgcgcggtg aacgacaagt ttgtcttcct 3463561 cgcctaattc atccataccg agaatcgcaa tgatatcctg aagctctttg taacgctgaa 3463621 gcgttgactg tacttcacgc gcaaccgcat agtgctcttc tccaacaatt tcaggagcaa 3463681 gggcgcgtga tgtagatgcc aacggatcaa ccgcagggta aatacccatt tcagttaatt 3463741 tacgctcaag gtttgttgtc gcatccaagt gagcgaacgt tgtcgccggc gccgggtcag 3463801 tgtagtcatc ggcaggcacg tagatcgcct ggatagatgt aactgatcca acgttcgtag 3463861 acgtgatacg ctcttggagc tgacccatct cagttgcaag cgtcggctga taaccaaccg 3463921 ctgaaggcat acggccaaga agggctgaaa cctctgaacc cgcttgtgtg aaacggaaaa 3463981 tgttatcgat gaagaacagt acgtcctgtc cttgtacatc acggaagtgc tcagccattg 3464041 taaggcctgt caaagcaaca cgcatacgtg cgcccggcgg ctcgttcatt tgtccgaata 3464101 ccatggctgt tttgttgatt acgccagagt cactcatttc gtagaaaagg tcgttccctt 3464161 cacgagtacg ctctcctacg ccggcgaata cagagatacc gccgtgctct tgcgcgatgt 3464221 tgttgattaa ttcctggatt aatacggttt tacctacacc ggcaccaccg aacaatccga 3464281 ttttaccgcc cttaatgtaa ggagcaagca aatcaacaac tttaatacct gtttcaagaa 3464341 tttcaacttc tgttgaaagc tgatcgaatg aaggcgcctg tctgtgaatc ggatcctttt 3464401 tcgcatccgc aggaaccggc tcattcaaat caatattttc tccgagaacg ttaaatacac 3464461 gtccaagtgt tacatcacca accggtactg agattggcgc tcctgtatct acagcttcca 3464521 taccgcgctg aacaccatct gtagatgcca ttgcgattgt acggactgta tcatcaccta 3464581 aatgaagagc gacctcaagc gttaaatcaa tacctacttc gttttcactt gcagctggct 3464641 gtgaaatttt aatcgcatta taaatttcag gcaagtgacc gtcttcaaaa cgcacgtcga 3464701 cgaccggtcc taatacctgg ctaacgcgtc ctttcttcat cgctatccct cctgacaaaa 3464761 tctttctatt ctaaagcggc tgctccgccg acaatttccg taatttcttg tgtgatggct 3464821 gcttggcgag cgcggttgta agaaagcgaa agtgaatcga taagttcctt cgcgttgtct 3464881 gtcgcgtttt tcatcgccgt cattcttgca gcgtgctcac ttgctttact gtcaagaagc 3464941 gcaccgaaga ttaagctttc tgcatattga ggaagcaaaa cctccagaac ctcctcttca 3465001 gatggttcaa attcataaga cgccgttctt tttccgccgc cgctgcccaa atcagataac 3465061 ggcagaagtt ttttctccgt tacttcttga gtaatggcgc tgacaaaatg gttataaaca 3465121 aggtgcaatt catcaaacgc accgtctata aacatttgaa tcgtttgacg ggcaagatct 3465181 ttaatttctg taaacgttac ttcatctcca agtcctgtta actcggaaat gatcggaatc 3465241 tcccgtttct taaagaaatc acggcccact cttccgatgg caatcaccgc atactcatcc 3465301 ttagactgat gacgttcttg catggcctga taagcactcc gtaaaaccga actgttaaaa 3465361 gcgccggcaa gaccgcggtc agacgtaatg acaaggtatg ccgttttttt cacttctctg 3465421 ctgagaagca tcgggtgctt cacgttgccg gaaactcttc cgacgtttga cacaacctct 3465481 tggattttat ccatatatgg cacaaatgat tttgcattgt tttcagcacg attcagctta 3465541 gccgcagata ccatctgcat ggcttttgta atctgacttg tttttttcgt tgacgtgatc 3465601 cttgacttaa tatcgcgtaa tgaggccaaa gatttcacca ccttttctct tcatctgcgt 3465661 aaaaagagag aaaaagagaa cctttttctc tcatcagcat tcgagttagt tgcttggtgc 3465721 aaatgtgcgt ttgaagcctt cgattgcagc tttgaagtct tcatcagcag gaaggtttcc 3465781 tgttttcgca attccgtcaa gcaggtcttt atggttttgg tcaaggtaca tgtagtactc 3465841 ttcttcaaaa cgtctgatat ccgccacagg aatatcatcg agatatcctt ttgtcagcgc 3465901 ataaagaata gctacttgct tttcaaccgg aagcggcttg ttcagatcct gcttcagcac 3465961 ttcaactgta cgcgcaccgc ggttcagttt tgcctgagtc gcttggtcga ggtcagaacc 3466021 gaattgagcg aatgcttcca gctcacggta tgacgcaagg tcaagacgca aagtacctga 3466081 tacttttttc atcgctttga tttgcgctga gccgccgaca cgggatacag acaatccggc 3466141 attgatcgct ggacgtacgc ctgagaagaa caaatcagat tgcaggaaga tctgtccgtc 3466201 ggtgatggaa atgacgttcg tcggaatata agcagagata tctccggctt gtgtttctac 3466261 gaacggcaga gctgtaattg atcctgcgcc tttcgcgtcg ctaagctttg ctgcacgctc 3466321 aagcagacgg gaatgaagat agaatacatc cccagggaac gcttcacggc ctggcggacg 3466381 gcgaagaagc aaggacagct cacggtaagc ggccgcttgt ttagaaagat catcgtatac 3466441 aacaagaacg tgcttgccgt tgtacataaa ttcttctgcc attgtaaccc cagcatacgg 3466501 tgccaggtac agaagcggtg ccggctgtga cgcagacgcc gttacaacaa ttgtataatc 3466561 aagcgcgccg tgtttacgca atgtttctac tacgccgcgg actgttgatt ctttttggcc 3466621 gatcgcaaca tatacacaga tcatgtcttg gtctttttgg ttcaggatcg catcgatcgc 3466681 aacagatgtt ttacctgttt gacggtcacc gatgatcagc tcacgctggc cgcggccgat 3466741 tggaatcagt gcatcgatcg ctttgatacc ggtttgaagc ggttcatgaa cggatttacg 3466801 gtccataacg cctggtgcag ggctttcgat cggacgagtt ttgcttgtca gaatcgggcc 3466861 tagtccgtca accggctggc ctagcgggtt tacaatacgg ccgattaact cttcaccaac 3466921 aggaacctcc atgatgcggc ctgttctttt tacttcgtct ccctcacgga tctcactgaa 3466981 aggtcctaag atgacgatac ctacgtttga ttcctcaagg ttttgagcca tacccaaaac 3467041 accgtttgaa aattcgacaa gttcaccggc catacagttg tcaaggccgt gcacacgtgc 3467101 aataccgtca ccgacttgga tgactgtacc tacgtcttga acttcaatat cagattgata 3467161 attttgtatt tgctgtttta tcagcgtgct aatctcttca gctttgatgc tcacttaggt 3467221 ttcacccctt ctatcgattt tccccggcta attgacgttc aatgcgctga agcttcccgc 3467281 ttacgctgcc gtcataaatc cggtttccaa tgcggacttt aataccgcct attaaatccg 3467341 tctgcacttc atttctgatt ctcagtgaag cgactccggc tttttttgca aacacttgtg 3467401 ataatggtaa catttctgca tccgtcagcg gtttcactga atatacgatt gcgtcttctg 3467461 tttgacgggc cacatttgcg agtttgataa actcatctgt gagctcaggg acaatcgcgg 3467521 cacgatggcg gtcaatcaaa agaaaaatcg tattgagtac ggactgtgac aaagagccaa 3467581 atgcattttg aatcagctct tttttcttcg cagccggcac cttcggatgg ttcaacacat 3467641 cattaagcgc tttttcattt tgaaatactt gttttacaac aattagctct tcttctactt 3467701 gattcagctg agcggactca ttggctatat caaaaagagc tgatgcatat cgtttagaga 3467761 cagctgatcc actcatcggc tttctcctac ctctttaaga tagtcctgga tcaatttctc 3467821 ttgcgcttgt tcatccagtt ctttttcgat cactttcgac gcaatcatga cagaaagaga 3467881 cgctacttgc tcacggagag cagaaaccgc ctgttccttt tccttcacga tttcagttct 3467941 tgctgcttct ttcagacgtt cagattctgc acgtgcagcc tgaataatct cttctttttg 3468001 cttctctccc agtttctttg cgttttcgat aagagtttgg gattcctgtc ttgcttcttt 3468061 taaaagaacg cgctgctctt caatcagctg ctgcgcttct ttattttttt cttcagcaga 3468121 cgtaatttct ccagcgatgt ggtcttcacg ctgtttcatt atgtttaata gcggccctaa 3468181 agcgtatttc ttcagaagcg ctaataagat taacatagct aacagttgga acaggatatc 3468241 tccgccgtta aacgacaatc ctagttcaag tggtaattga gacatctact acggcaactc 3468301 ccttctgcag gtttttcttt gctgatccag cagccgcact tgtctctttt cagccggcaa 3468361 ggcgggatgc ttatcagaca taaagcaatg gcgaaggttc tcttggaatg atcttcgcca 3468421 tttttagttc atataaggct tttatgctta gccaaagaac gctaagaatg cgataacgac 3468481 agcgataata ggaagggctt caactaatgc gatacccatg aacataagag ttctcagttc 3468541 tttacctgct tccggctgac gggcaatccc ctctaccgta cgtgaaacaa tcaaaccgtt 3468601 accaatacct gcaccaagtg cgcctaaacc aattgcaatc gcagctgcta ttaaattcat 3468661 gaaaaagttc ctcctttaaa atgttatccg tttggatata atgttttaat gatcatgact 3468721 gattttatga gacatgtaca ccatcgtcag cattgtaaag ataaatgcct ggatagcacc 3468781 aataaataaa ctgaatgctt gccatgccag catcggcaga atggcaccga ttgtaccgac 3468841 aagaccgaga gccacgcttt gcgaataatg gcttgttgct aatcccgcaa gcaggccgag 3468901 aagaatctca ccggcgaaga tgttaccata cagccgcaaa cctagagtca gcgtattcgc 3468961 aaactcttcg atgattttca tcgggagcat gaatggaaca ggtcttaaat agtctttgga 3469021 atattccttg agccctttca tcttcacacc atagtagtgg gttaaagcaa caaccatcac 3469081 ggctagcgtt aatgtaatgg caggatcggc tgtcggagac ttccaccaga gctcatgtcc 3469141 gattgtaata gagaacggca gccccagcat attcgacaca aatatgtaca tcagcaatgt 3469201 gacaccaagt gccaagaagt tagcccctgt ttttaaatcc attgtactgc caataatatt 3469261 gcggacgaaa tcaacaatcc attccataaa gttctgggct tttccgggac ggatcgaaag 3469321 cgttcttgtc gtcaatatag caatcaataa aacaatcaca ctcgccacag taatcatcag 3469381 aatgtttgtc agattaaaag taagacctag aaattctata gttctgtaac catgattcaa 3469441 agggttttca cctctcttcc attgatgaac gtttaagctg gataaaggaa tctatcataa 3469501 tgacagggta tattgtcatt aatccaataa ctgtacttgc catatgaaag tattcgggat 3469561 ttttataggc aacagccaca gcaagaatcg cattgcacca ccgcgctgcg ctcccgagag 3469621 atcgtatgga ctttcctttc tctacagctc tgtcaaaagc attcattctt ctgacgagca 3469681 gtaaaaaatt aaacaaactg aaaacagttc ccagaataag gcctaaaaaa acggttttat 3469741 acgctgttaa accataaccc agtacataca ctgccaaaat gaacaataaa tatttgcgtt 3469801 gtctgctaaa tgtaagcttg ggatcgtcca tcaattatct gtctcctgat gaaaaaataa 3469861 tgtatagctt ggatacggca aaaatcagcg gttaaccctt agtagaagac cttttttgac 3469921 cggcaaaacg ggcctgttcg aaaaaatcat tcatccgcaa gccttgcagg gatgctgttt 3469981 cattcgctta aataaatcct cataatacgg gtttgctgag aggatttaca ttgaggatga 3470041 ggactataat gaaagctatg aaaaccttct cataataccc tcgtttagca tacaatagcc 3470101 cctaacatgt gtcaatctgt ttaaagttaa aaaacttttt atactttacg tctccacaga 3470161 atgttcacat tttcacctat aattgtatac agattcaccg aatagcaaaa aactggataa 3470221 aaaaatgaaa cccccttttg gggatttcat tttttatttt gttccaaaca tgcggtcacc 3470281 cgcatctccg agacctggaa caatatatcc tttttcattt aatttttcat ctagcgccgc 3470341 aatgtaaata tcaacgtccg aatgatgctt ctgcaattct tccacaccct ccggcgctgc 3470401 tacaagacac atgaaacgga tatttttcgc accgcgtttt ttaaggctgt gaatggcttc 3470461 aactgcggaa ccgcctgtag cgagcatcgg gtcaaccacg atgaattcac gctcttccac 3470521 atcagaagga agcttgacat agtattccac gggttttaag gtttctggat cacggtaaag 3470581 gccgacatgt cccacttttg ccgcaggaat cagctttaaa atgccgtcaa ccattcccaa 3470641 tcctgctctg aggataggaa ccactccgag ttttttccct gagatgactt tcgatttcgc 3470701 agcctgaacc ggtgtattga tatccacttc ttccagagga agatcgcggg taatttcaaa 3470761 tgccatgagt gtagccactt catctactaa ctctctaaaa tccttcgtac ctgtattttc 3470821 attccgtata tatgtcagct tgtgctgaat taaaggatga tcaaatacat aaacctttcc 3470881 catactgtgt ttcagctcct tttttattgt cccatcaaca attacacact tctattgatt 3470941 ctacaaaaaa agacattgag tttcaagaac atcgtcaaaa aacccgccgg gcataagccc 3471001 aagcgggttt taggatctta ataatctaat tctttatata aaggaaattt atcagtcaga 3471061 gcagctacac gctgtcttgc ttcttcaagt tttccttcat cttcgtggtt tttcaatgca 3471121 agcgcaatga tagcaccgac ttcttctaat gcgtctccgt caaaaccgcg gctggttaca 3471181 gcagctgtac caagacggat gccgcttgtt acgaaaggtt tttcaggatc atatggaatc 3471241 gcgtttttgt tagacgtaat accaatttca tcaagtacat gctccgcaac cttaccagtc 3471301 agtccgagcg aacgaaggtc aacaaggata aggtggttgt ctgttccgcc tgaaacgagc 3471361 tggatgccct ctttcgttaa ggcttcagcc agacgtttcg cgtttgaaat gacgttttgt 3471421 gcatatgttt tgaaatcgtc ctgcaatact tcaccgaatg aaacagcttt tgcggcaata 3471481 acgtgcatca gagggccgcc ttgaattcca gggaagatcg atttatcaat tttcttgcca 3471541 aactcttcac ggcaaaggat cataccgccg cgaggaccgc gaagtgtttt atgtgttgtt 3471601 gttgtaacga aatcagcgta aggaaccggg tttggatgaa ggcctgccgc aacaagtcct 3471661 gcgatatgtg ccatatccac catgaagtaa gcgccgactt catcagcaat ttcacggaat 3471721 ttcttaaagt cgattgtacg aggatacgca cttgctcctg ctacgataag cttcggttta 3471781 tgagcgaggg ctttttcacg cacgtcatcg taatcaatat attgagtttc tttatctacg 3471841 ccgtactcaa caaagttata ttgaacaccg ctgaagttga ctgggcttcc gtgtgttaaa 3471901 tggccgccgt gggagaggtt catcccaagt acagtatcgc cttgctccaa aatcgtgaag 3471961 tacactgcca tgtttgcttg tgcgcctgaa tgaggctgaa cgtttacatg ctccgctcca 3472021 aagatttcct tcgcgcggtc acgggcgata tcttcaacga catcgacgtg ctcgcatccg 3472081 ccgtagtagc gtttgcccgg atatccttct gcgtacttat ttgtcaaaac agatccttgt 3472141 gcttccataa ccgcttcact tacaaagttc tcagaagcaa tcaattcgat cttagtctgt 3472201 tggcgttcac gctcattttt aatggcgtta aacacttgtt cgtcttgcgc aggtaaatgt 3472261 ttcatcagcg agatcctctc ctatccgtat cctgttcttt gtttttacca tcactattgt 3472321 acatggtttt taaggccgat gtaaaagatt atttttaaaa aatctaaatt tttattggta 3472381 aaaacgaata ttaataactt aaatttaatt taaagttcgg aatttatttc actatcttaa 3472441 aataaaagaa aagactggct atgcagtcct ttcattcgca ctcataaacc gcccgcactc 3472501 cgccgattag tttcggccgt gtacgcgcca atgtcacatg agctgaaccg aggctgtttt 3472561 gagagacacg cacagggaca gccaccggtt tcagatgcat gccgataaac gtatcgccta 3472621 tatcaattcc ggcgtcagcc tgaatggttt caacaagaac aggagacttc atctgcttaa 3472681 acgcataaga cgccatcgct ccgcccgctt ttggaacggg cacggcagaa acggttggaa 3472741 gcctgaacag cttggctgtt tctgcttcga cgacaagcgc tctgtttaaa tgctcgcagc 3472801 attgaaacgc cagatggatt cccgtttttt cccggagctc agcaagtccg ctgtagatgc 3472861 tttcagcgat atctacactg cccgatgtgc cgatccggct gccggccact tcgctcgtgc 3472921 tgcatccaag gacgaagagc tgatcttgtt tcaattccgc ttggtcctga aactcagaca 3472981 gcatcgtctt ccacgtttgt ttcaactcat tcattaaaca gcacccctac aggtttttct 3473041 cttcataatc ggagattttt ccaatacgcg tttggtgtct tcccccggta aactcagtag 3473101 tcagccagat ttttgcgatt tcccgagcca aaccaggtcc gatcacccgt tcacccatcg 3473161 caaggatgtt tgtgtcatta tgctccctcg tcgccttcgc gctgaaggta tcgtgcgcca 3473221 gcgcgcagcg aatccctttt actttattag cggaaatgct catgccgatg cctgtcccgc 3473281 aaattaaaat gcctctgtca acttcgccgc taaccacttt ttcggccacc ggaaaagcat 3473341 aatccggata atcgacagag ccgctgccgc agtcacagcc catatcaata tattcaattt 3473401 gcaattcgtc cattaactct ttgatttcat ttcgaatgtg aacgccgcca tgatccgatg 3473461 caatggctac tttcatctgc ttttcctccc agcgtgtgtg atgcggcccg cccgctttat 3473521 tgaccgcgca gcctgtccgc tctttgattc acaccatatg atgtgctttt cactatattc 3473581 tactccttca cgcaggattt gcaaatgacc tgtttgcaga ttttctgaca acttatctac 3473641 ggtctttttt cagctgtttt gccagctgcc gaagaagctc ttcaagctca tctcgcgttt 3473701 gtttatagat gtcaattgag ccgccgaacg gatcgaggac atcaccatgg ctgcctgtga 3473761 catattcttt taacgtaaac actttatcac gataacgtcc aaattggctg gcaatgatct 3473821 gtttgtgctg atgggtcata gccagaacca aatcagccga ttccataagt tcttcagtta 3473881 atggagaaga cacatgatta agggcaatgt gtttttcaaa cagcgcttcg actgcatgag 3473941 gcgtcgcttt cccattaggt gaagcaaaca cgcctgccga gcggacattg acattcagcc 3474001 cttccctttc tgcaattgat ttaaaaagcg cctcagccat tgggctgcgg cacgtatttc 3474061 cagtacagac aaaaataata tccatgtcag tcacccctta tttttctcta ttatatatga 3474121 agaaaaaaga aacggcgact tcgtttcttt tattggtata ttaaattggc aaaagcagct 3474181 ttaatccaaa cacgattaat atgatgcccc cgagcgcttc gctgtatgtg ccaagccatg 3474241 actgcacttg ttttccgacc agcaggccca gccatgtcaa catcatgctg aacagcccga 3474301 acagggtaat tgtgaggagc ggatgcgagc cgtatatccc caagctcaag ccgacggaaa 3474361 agctgtcaag gctgacgccg atggcaaaca gcaataagcc cggccctgcc ggtgacatga 3474421 atcgttcttc tgactgttta aaagaggcca taagcatttg aaccccaaga acaaaaagca 3474481 gcgccccacc gatataaacc gctaacacgc cgaggagccc tgacagcatg ttaccggccg 3474541 ccatccctgc gagaggcatg atgacgtgaa agaggccgat gatgaaacca atatagaata 3474601 tctgcttctt tctaagtttg accatgccca ttccaaggcc gacagaaaaa gcatccatcc 3474661 ctaaagcaaa cgccatgatg cttaatgtaa tcagttcgcc tataaacaaa tccgacatac 3474721 ataaataacc cccttggaca cgccccgctt ttttagccta tgcgtgtcca aaaagggtta 3474781 gaacatctga ctgctttcag cgaatcactc ttcctccggc ggctttcatc agcctgttca 3474841 taatagcaag accgacacct gtatccggaa aggattccgc tataatgaaa tccaccttat 3474901 tctcatcaaa gctgcgcaaa gcatcataca gccctgccgc aacagtctca agctgagccc 3474961 gtcttccgca gctcttcaca taatcagcgg aataaacgcc cgctttttct tctgtcgtca 3475021 ggacaccgac ccgtcttcca ccctgttgat attcttgaat gaggtgctga atgcgctctg 3475081 ggctgccttc gcaaatggca agaggcgctg tcggcgcata atgtgtatat ttcatccctg 3475141 gagaaatcgg cttctcgttt tggtcgctga gccctttatc cacatggatc ggcccgatca 3475201 ccgcttcaat ttgttccttc gtaatgccgc caggacgcaa gagaacaggg atgtcgtccg 3475261 cacatgaaag cacagttgat tcgaccccga ttccggtagg gcctccatcc acaataccgg 3475321 ctatgcggcc atccaagtcg tgagccacat gctccgcttt tgtgggactt ggcttgcctg 3475381 atagattggc gctcggtgct gcaatcggca gtcccgattc gcgaatcaat gcaagggcaa 3475441 gcggatgatc cggcattcta atggcaaccg tttcaagacc tgccgttaca cgaggtgaaa 3475501 gcgcatcagg tttgcaaggc agaatgagcg taagtgctcc cggccaaaac cgtttcatca 3475561 atgttttcgc cttttccggc gccgggcccg ttaaatcctc aagctggctg atatccgcaa 3475621 tgtggacaat caggggatta tcgctcggcc gccctttcgc ctcatatatt tttttgacgg 3475681 catccgtatt ttttgcgttt gcgcctaggc catatactgt ttctgtcgga aaggcaacga 3475741 cctcattttc tcggagcaaa gcggctgctt gtgcaatttg tggatcattt gtggataact 3475801 cgtcagttac atccacaaac catcttttcg ttttcatttc tgaccaaact ccttattcac 3475861 aacaataaaa cgattgtttt acgcgtgtaa tccttttgaa agtataaaag atgtcctgta 3475921 ataaaacaag cgttatccac aaattgtgga caacgctaat aaagaagtgg ataagtatgt 3475981 gtataaactg cacttatcca gacgcttttt tcatcaaaac ggctccttct gtttgccgcg 3476041 attcacagaa gtgatcagaa gaaaacagct cctccggtac actctcagct ctttcaaaac 3476101 ccatggccgt cagaaagtcc gcagaggaat gctgatttgc tactaggtac acggttttga 3476161 tctgatgctt ttcgcacagc acctccatgc tttgaaaaag cgtgacgatg tggccttggt 3476221 gaagcttgtc cgatatgaca agtgatcgca gcagcccctg gtcacagctt attttttcaa 3476281 taccgaggca tccggcaatg tttttctcac tgtcctccag cataagaaat tgagtgaagc 3476341 cttctttcac gccttcatag ctggtttttg cctgttttaa aaatgcctcg agcacatctc 3476401 cgtctttttc ccttgccacc cgcagttgat aaaacatccg ttcaccccgt ttttgcgttc 3476461 tttcttccaa tctatgaggc aaatctattt ttagaccaga tgattaggaa aaaaggtcgg 3476521 aaatccattc gactaaaaag aatttcactt ctgtgccgtc ttctttttct tcgttctctt 3476581 cttttttggc tttttccgct ttagcggtta cgtcctcaag cactttttca gtctgctttt 3476641 ttgaggcttc tttatcttct tgttctttga cggcttcccc gttagaaaaa tcaagaaagc 3476701 agaggggcgg gaacagcaca caccaccagt tggcgccgtc tccgtttcca agcgtaatca 3476761 aaatcgcttc atactcacca gcgggatata ccatgttgcc gtaaagcttt gtcggaaacg 3476821 agattttgtc aaaatcaacg gatatcgact gattcgctcc ttctttctcc attgtttcct 3476881 ttgcaattgc tttgatttca ggcagctttg aacgaatcac gcgacgcgct tcttcaatag 3476941 aagtaatatc ctttacccaa gttgtgattt ctttattcac cgcgtctctt atatgacgtt 3477001 ttaattgctg gtcttgatca ctatcgctgt ttgccagtat tctcaaacga atcgcctgat 3477061 caggtatgac caccggctga ttttccgatt tttgtgccgt ctcttctttt gccagcccta 3477121 cgagcgctcc ggataataaa agaaagatat atatacaaat gattactgtt tttttcatcg 3477181 gtccccaccg ttcctctccg tgctttgttt ctagccctat tatggacaag gagagcctgg 3477241 gataaacgtg cagggtgaaa aaaatctagc aagctgttaa tcttatttat ggtacgatag 3477301 tgttttagga ggtttaagat gaaatacaat tatacagtgc tgttatcagc attcacgatg 3477361 tccgttcttt attcagtaat ttatattcat tcatttatca ttgccgctct catcacaatg 3477421 gcattttatt ttctgtttcc ttatttgatc ttcgcactgc cgcttcaaat catgatgaat 3477481 aaaaagccga aacgtttcag ccctttgtat ctgctgtatt accttgccgc tgcttttatt 3477541 gccaacgcga tcattttcgg catgcttcag ccttcgggac aatctctgtt tcaaaataca 3477601 gccttttatc ttttcgctgt attaacagct cttatctatt ggatatggga ttctgtttta 3477661 ctgcaaaaaa aggaagccta agaggcttcc ttttttatta aaacaaaatc gtcagtaaat 3477721 aacatagaat ggaaggtatc gccgcaacaa agaaagcggc cgccattttc atgcgagatg 3477781 tacggccttc tttggtttct gaatggtagt ttgcccgctg atcgcttccg cttacagcca 3477841 aacccgatgt aatgatcgcg agccccacta aaacgagaga cgcaacgcca aaaatcgctt 3477901 catatgaaag agcctgcgga aaaatggtgc caatcatgct ctcaatcgca atgagcagga 3477961 ttcctgctgt cagggccttt ttcatgttta catccccttt gctggtgtta aacagcttga 3478021 tccattcact cgccagcaag ctgcttattt atttttatga atcagagcgc atatggttct 3478081 gtcttttcca ttaatatctt tcagcacttc cacttccgcc cccttaaacg ccttgaggat 3478141 caggtctttg accgccgctc cctgtttcca gccgatttca aaaacgacaa atactttatc 3478201 cttcataaca agcggaatgt cttccataaa ccgcttataa aatttcagcc cgtctccgcc 3478261 atcggtgagt gcgtgcagcg gctcatgaaa acggacaatt tccgataaat cagccatttc 3478321 ttcctctgaa atatatggcg ggtttgagac aatgatatcc gctttttttc ccgccttaat 3478381 aaaaggctca agcagatcgc cctgataaaa gcgcacattc gctccgagtt tttctgcatt 3478441 ggcagaggcg acttgcagcg cctctttcga aatatcgacc gccgacacag aaaagctttg 3478501 gttttcaagc gcaagcgtga cggctattgc gccgctccct gtaccaacgt caacaacttc 3478561 gagcttgccg tcttcagaaa aaacactccg atatttttca agcaaatgaa agacaacttc 3478621 ttcagtttcc ggccgcggga tcagcacatc atcattcacc ataaattccc gtccataaaa 3478681 aaactctttt cctataatgt attgaaccgg cacgccctct ttatgcatct caacgtgacg 3478741 cttaaagcga tacagttcgt cttcaccaat cggttcctgt aagcttgcga gcagcttgct 3478801 tctctccatt ccggtatcat aaagcaatag gagctcggcc gcattttctt ctcttcccgc 3478861 ttcggttaaa taagaagaag cccatttcag ggcttcgaat atcgtcttca tcttaacctt 3478921 ccgactgctg aagcttgctt gcctgatctt caacaatcag cgcttcaacc acttcgtcaa 3478981 gttttccttc aagaatctga tcaagctttt gaatcgtcaa accgattctg tgatccgtca 3479041 cacggttttg cgggaagttg tatgtgcgga tacgttcaga gcggtcacca gatccgactg 3479101 ctgatttccg tgtttgatca tattcagcct gggcttcctg ctgaaattta tcatagattc 3479161 tggcacggag aaccttcatt gctttttctt tgttcttaat ttgagatttt tcatcctggc 3479221 atgatacaac aacacctgtc ggcaagtgag tcagacgaac cgcagacatt gttgtgttaa 3479281 cgctttgtcc gcccggtccg cttgaagcaa atgtatcgac acggatatcc ttctcatgga 3479341 tgtcgacctc tacctcttct gcctcaggaa gacatgccac tgttgcagtg gatgtatgga 3479401 tgcgtccgcc tgattctgtt tccggaacac gctgtacgcg gtgggcgccg ttttcatatt 3479461 tgagtttaga atacgcgccg cttcctgtaa tcataaagat gatctctttg tagccgcccg 3479521 ttccggttac attcgcttcc atgacctctg ttttccagcc ctgaagctca gcataacggg 3479581 aatacattct gtacagattg cccgcgaata aagcggcttc ctcgcctccc gcagccccgc 3479641 ggatctccat gataacgttt ttgtcgtcat taggatcttt cgggatcagg agcaccttca 3479701 gccgttctga cagtgtttcc gtttccttct gaagttcaga aatctcttcc ttcaccatgt 3479761 cgcgcatctc agcatccagc ttctcttcaa gcatcgcttt tgcatcagcc agctgttctg 3479821 acgcatctct gtattgtcta tatacgtcaa ctgtttcttg tatatcagat tgctcttttg 3479881 aatattctct tagctttttc ggatcgttga ctacttctgg atcgctcaaa agctcattta 3479941 atttctcgta tcgttcttca attgatttta aacggtctaa cacggtcttc acctctgttt 3480001 tcctgtgcgt aacattctca ttatagtata gtgattaacc ccagtcaaaa gcatttcaat 3480061 cccagctgga aaagctccct ctgctatact ggaattcgag gagggatgat gttgctgaaa 3480121 tccatacatc atattgcaat catatgttca gattacgaaa agtcgaaagc tttctacgta 3480181 cataagcttg gttttcaggt gattcaagaa acgtaccgcg aagagcgcgg ctcctataag 3480241 cttgatttgt cgcttaacgg ctcgtatgtc attgagctgt tctcgtttcc cgatccgccc 3480301 gaacgacaaa cccggcctga agccgcaggc ctgcgccacc tcgcctttac agtcggcagc 3480361 ttggataaag ctgttcaaga gcttcatgaa aaaggaatcg aaacagagcc aatcagaaca 3480421 gatccgctga ccggcaagcg tttcaccttc ttttttgatc ctgaccagct tccattagaa 3480481 ctgtatgaac aataacagtt tttgaagaaa aaaaggagat acccactttc tttgccgaat 3480541 cttttcttgt tttgtctaac gggaagggaa ccgcattcta tggtcgaata cctagcttaa 3480601 aaggaggtat gggatcatga atacaaatat ggtagcaagt gaactcggcg tctccgcaaa 3480661 gacggtgcag cggtgggtga agcagctgaa tcttccggcc gaacgcaatg agctcggaca 3480721 ctattcgttc acggcagaag acgtgaaggt tctaaaatcc gttcaaaaac aaatctctga 3480781 aggcacggcg attcaggata ttcatctgcc gaaaagcgct aaaaagcgca caggcttcct 3480841 tgtccaaaaa acaagtagcg acacagaacg aagaatcgag cagcttgaac aaaagctgga 3480901 caccctttta cagcaaaggc aggacgaaag cgaattgatg gcaaggatgt cggaactgga 3480961 acgccagctg aaacaaaaag ccgatgaagg tgtatcttac cagctgcttc agcaccgcag 3481021 agaaatcgat gatattcttg cagatctgca atcactgacc tcacaaatga aagaattcac 3481081 cgctcattcg atccccgaga ctgctgctgc ttctgaaaaa accaaaacaa gaaaaaaacc 3481141 gctgctgtca ctgttcaaat ttcaaaccta aagcaaaaag ctcccttaaa gggagctttt 3481201 tttgttacgc agtaagcgcg ataatgattg gaagtgaaat caatgacaga atcgcactga 3481261 ccacaaacgc agttgcagtt tcttcttctt gtttctcgaa acgagtcgca atcatggctg 3481321 caacggcaga accagggaat gcaacaagaa ggattgcttt tgttgtttgg tcagctggaa 3481381 gtccgatagc aagagcaatc aggaacatta acgcaggctg aaccgcaact tttagtaacg 3481441 caataccgat agccggcata ctgagtttaa ttttacgaat accaacggta acaccaacag 3481501 cgaagagagc aacaccagat gttgtgcttc caagctgatc aagcatttta acacccagct 3481561 caggaagagt gaaattgaaa accagcacca agatcatact gattaacgga gcagctgcaa 3481621 gcggctcaca aagaccatgc aggattgatt ttcctgtcat cttccagaag ctgtcgccac 3481681 tctcttcgtt tttcttagaa gactcaccaa cagtagcgat aatgatcgcg agcggatcaa 3481741 gaatcgcgtt aaccacgata cctgtgaccg cgatcggaat cgcaacttca ttcgctccga 3481801 ataagcttcc caataccggg atacccataa atgcgaatgt cggctgtgca gagttcaaag 3481861 aaaatacaga tgagttcgtt aaatcatact tgaatataaa tctgcaaacc aaaagaatga 3481921 tgatatagaa accaacaatc ccaataatta aagaaatcat taaaggtact tgtgataaaa 3481981 attcacttct ggaagttgtc aaaataccag cgataaagtg agctggaagt gcgtatttcg 3482041 ttactaacgt acttacccct tttgccgact tggcatcata acttccaaaa tgtcctgcaa 3482101 accaacccag cacgataaca aagaagatcg gcgccaggag gattaagata tctaagatgc 3482161 tcaaaatatt ctcctccaaa tcctatgtcc gtatacttta gctttacaaa aagctttccc 3482221 tcggacagaa aaatttactc gctaattatt tcgcgatgac ttttttgtat tcaggtgtcc 3482281 acattgcatc aagtaccgct tgtttcacat cttcaggctg acgatttgcc acgccgtctt 3482341 taattgctgc ttcagcaacg gcaatcgcaa cttggataga aacctcttga agcttatcaa 3482401 tgcttggaag caatcctgct ccaggtgttt caagatcaac catttcagca atcgcatcag 3482461 cagttgcagc aaacatagca ggtgtaatga tacgcgcttc agctacaatt gaaccaagtc 3482521 caagaccagg gaacgcgaat gcgttgttag attgtccgat ttcataagaa acaccgttgt 3482581 attctacatt gtcaaatggg cttcctgttg caataagcac ttttccgtca gtccatttga 3482641 acagatcttc aggaacagct tcagcaaggt gagtcgggtt agacatcggc atgataaccg 3482701 gacggtctac gtgagatgcc atttctttta caatttcctc tgtgaatgca cctgaaaccc 3482761 ctgaagtacc aatcaagatt gttggtttcg cttgacgaac aacttcatcg aatggaattt 3482821 gacctttttc atcgcgcttc cagtctttca cttcatccgc attgcgaagg taaggttttt 3482881 ggaaatcaag gatgccttcg atgtcttcag tcagcaagcc tctgtaatca agtgtgtaga 3482941 aacgtttgtt agcttcttct tcagataatc cggctagcac cattgtgtca cggatttggt 3483001 cagcaatacc gataccagca gaaccagcac cgaagataac aacacgctga tctttaatag 3483061 aagcgccggt tttcttcata gcggcaagca cacctgcaag tgtaatcgcg ccagtacctt 3483121 gaatatcatc attaaatgtc aggatttcat gattgtattt tttcatgatg ttgcgtgcat 3483181 ttttgttgcc aaggtcttcc cagtgaagaa gcgctttagg gaagaatttc aatgcagctt 3483241 ttacataagc gtcaatgaaa gcttcgtagc gttcaccttg aacacgttca tgcttgttac 3483301 caatatataa aggatcgttt agaagttttt cgttgttcgt accgacatca agcacaaccg 3483361 ggataacacg gctagggtca ataccagctg cagcagtgta gacagccaat ttaccgattg 3483421 caatattaat accgcctaca ccccagtcac cgataccgag aatgctttcg gagtcagtag 3483481 caacgataag atcaatatcg cctgctgtcg catgaaggtt ttcaaacgct ttttcaatac 3483541 cgtcaatgtt atcgattgac aagtagattc cttgaggtct tctatattca tggctgtatt 3483601 cctgaatcgc ttcaccaact gttggcgtgt acacaacagg aagcatttcg cgaagatggt 3483661 ttttcagcaa tttatagaaa agaacttcgt tacggtttgc aagatcactt aagtaaacat 3483721 tttgacgaag gcggtcaggc tgcgcttgga attgctcgta cgcgcgttgt gcttgttgat 3483781 caagagaaag tacagttggc ggcagaagcc cttctaagcc gagttcttgt ctttcttcta 3483841 gtgaaaaagc aacgccttta tttaaagtag gaatagataa aacttctttt cctctaagag 3483901 ttgtttctaa gtggccttct ttcgtttttt ttatgttatt caagcaaatc tccttctttc 3483961 ttgaaatagt taaccaagtt aagtaataac ccatctaaaa tatgaccgat catgatcttt 3484021 atgcgacttt gtgacaatta ttcgaacaat gtctcaaaac tatttacatt acgtaagcta 3484081 ttgtatgcct gtcaaaatca aaattcaaga gaagaaaatt acttaatttt ttaatatact 3484141 tatttaaatt ttttaattga atattatcag aatataaaaa aaacaccggt gtttttagcc 3484201 ggtgcattct atctttatac ccatgttttg gactattttt tagatttacc tgggacttcg 3484261 tgatgatgtc tgcatcttgc ttcatatgat tcagctgcac caaccaaaat gaccggatca 3484321 tcgtaagaag caggtttgcc gtcaatgagg cgctgtgttc tgctcgccgg tgatccgcaa 3484381 acagaacaga cggcttgcag ctttgtcaca ctttccgcaa tcgccatgat attcgggacg 3484441 acaccgaacg gctctcccct aaaatccata tcaaggcctg ctgctatcac acggtagcct 3484501 ttatcggcaa gagatgataa aacctcaaca atttcctgat caaaaaactg cacttcatca 3484561 accgcaacca catctgtact ttcactgatg tgatcccaaa tgtccgcagc agacgaaatg 3484621 gcatagctcg tcatcgatgt tccattatgg gagacaacag cagcttcgct gtatcggtta 3484681 tcaattacag gcttaaatac cctgacttcc tgcttggcat aagttgctct cttcactctt 3484741 ctgatcagct cttcagattt ccccgagaac atgctgccgc aaatcagctc aagccacccg 3484801 ctttgtttca ttatgtacat aggcttcgct cccctctctc tgccagctgt gttttagaca 3484861 atataaaaaa caggcaagac tgctgcttgc ctgttgagaa atctattatt acttaagacc 3484921 gtattttttg ttaaagcgat caacacgacc atcagcagaa gcgaattttt gacggccagt 3484981 gtagaatggg tggcattcag agcaaatctc aacgcgtacc tcttctttta ctgagcctgt 3485041 ttcaaattca tttccgcaag cgcatttaac tgttgctttt ttgaaattag gatgaattcc 3485101 tgctttcatt gtatccatct ccttccgccc tgaatcccgt gtggaaacag agttattatt 3485161 tcggagcatt gtccgaaacg catatgagaa aattatatca gtgatttact tcttttgcaa 3485221 atacaattta ccttcttgca gatgatagat ttgcctgttt ccattcttga ttgagaatat 3485281 cgaaaaattc ctggtttgtt ttggtttttt tcatttttct catgaacttt tctgcgaaat 3485341 caggtgaatc agacatcgtt ttgcggatag accataaacg atcaagatgc tctttaggca 3485401 caagcagctc ttctttgcgc gttcctgaac ggcggatatc gatggcaggg aagatgcggc 3485461 gctcggcaag agagcggtca agatggagct ccatgttgcc tgttcccttg aattcttcat 3485521 aaatgacatc atccatacgt gaacctgtat cgaccagagc cgtagcaagg atggttaagc 3485581 tgccgccctc ttcgatattt ctcgcagccc caaagaagcg tttcggacgg tggaacgccg 3485641 ctgggtcaat ccccccggaa agcgttcttc cacttggcgg aatcactaag ttgtaggcgc 3485701 gggcaagacg tgtgatgctg tccatcagga taatgacgtc ttttttgtgt tccacgagac 3485761 gcatcgcacg ttcaagcaca agctcggcca ctttgatatg gttttccggc acttcatcaa 3485821 acgttgagct gacgacatcc ccagctacag agcgctcgat atcggttact tcctcaggtc 3485881 tttcgtcaat taaaagcacg atcagctctg cttcaggctg gttcgctgta atgctgttgg 3485941 caatttcctt cagcaacatc gtttttccgg ctttcggcgg cgcaacaatc aatccgcgct 3486001 gcccaaatcc aaccggcgcc atcatgtcca taattcttgt agacaagaag ttcggctttg 3486061 tttcaagcac catttgacga tccggataaa gtggcgtaag agccgggaaa tgcacacgct 3486121 cttttgcaga ttcgggatca tccccattta ctgcttcaac gtgcaaaagt ccatagtaac 3486181 gctcattttc ttttggcggg cgaaccttgc cagatacttt gtctccgttc cgcaaatcga 3486241 aacggcggat ttgtgaagct gagatgtaaa tgtcttctga gcttggagag tagttgatcg 3486301 gtctcaggaa tccgaaacct tcagactgga tgatctcgag aacgccttcc ataaacagca 3486361 gatcttcctg ttctgcattc gctttcagaa tggcgaaaat gagttctttt tttgtcagtt 3486421 tgctgtaata ggagatttta taatgtcttg caagttcata aagctctttc aatttcatat 3486481 tttccaaaga ggaaatagat acgtctttca taaaaacacc acgcttttca tagtcaatat 3486541 cttactctga acatgtcatc tgctgctttt gcacaacatc cgccaaagca cattcttttt 3486601 ttaacataaa ggaacttcta tcggtaacac ttccacccat gatcggcgct tttgttaaaa 3486661 ggattgtctt aatgagtttt gaaggaagcg aggacaaaaa catgagaaga tcaatactta 3486721 tatcgtctgt atgcggtaga aattgaaact ttcctagtgc ttaaaagaag gtattacgca 3486781 gtaaaattcg cagcactctt tatttttacc ttatttcaaa aaattattca actgaaataa 3486841 ggttttgaca cggaattgat agagttgacg cttttctgca aaagttaaag cgggctcaca 3486901 cccgcttttt ctgtttgtta tggacggatt acaagatttg gtttcttttt caagctgtgt 3486961 ctgccgtcaa cgaaacgaac agtgcccgat tttgcacgga taactaagct ttcagttgta 3487021 ccgacagagc ctttgaattg aactcctttt aacagctcgc cgtcagtaac ccctgtagct 3487081 gcaaaaatcg cgtcatcacc cttcacaagg tcttccatgc gaagcacttt gcttaaatca 3487141 aggcccattt tgtgacagcg agtgatttct tcttcgcttt gcggaagaag tttaccaatg 3487201 atttctccgc cgagtgcttt tagcgcaaca gcggaaagca caccctcagg agcgccgcct 3487261 gatccgaaca ggatatcaac gcccgtgtgg tcgaaagccg tgttgatggc gcctgcgaca 3487321 tcgccgtcat tgatcaattt gattctggcg ccggcctcac gaagctcgga aatgattttt 3487381 gcgtgtcttt cacggtttaa aattgtggca acgacgtcct caacgtcctt gtttttcgct 3487441 tttgccaccg ctttaaggtt gtcaatgaca ggtgcttcga tgtcaatgca gcccaccgct 3487501 tccggaccga ctgcgatttt ttgcatatac atgtcaggag cattcagaag cgtgccatgg 3487561 tctgcgaccg cgataaccgt cagcgcgttc cagccgccgc ttgctaagat gtttgtgcct 3487621 tcaagagggt caactgcgac atcaacgcga gggccgtacc cgtttccgag tttttccccg 3487681 atatacagca ttggcgcttc gtccatttcc ccttcaccga ttacaacggt ccctttcatc 3487741 ggcactgtat caaaaacgtc tctcattgca cttgttgccg cttcatcagc ctcatctttt 3487801 tttccccggc ccatccatct tgctgatgcc aatgccgcag cttctgtcac acgtaccaat 3487861 tccattgata aacttctttc catttcaaca cgatctcctc tcacaagaaa ccattatgaa 3487921 ttttgaagct gttctatttc ttcgtcagtc attctttcac gccaaattgt cgctccaagc 3487981 ccctcaagct tcttctcaag gctgctgtat cctcggtcaa tatgctccag tcccgtaatt 3488041 tccgtgacgc catcagccat cagtccggct accaccaagc aggctccggc acgcagatca 3488101 ctcgccttca cttttgcgcc ttgaagctcg acaggacctg tgatgatggc agatctgcct 3488161 tctactttca tattggcacc cattcgtctc agctcatcaa tgtgcttgaa tcttgccgag 3488221 tagatggtgt ctgtgacgac actcgtccct ttcgcccttg tcaggagcgc cgtcatcggc 3488281 tgctgtaaat cagtcggaaa ccccgggtat acgagggttt tgacgtcaac cggctttaag 3488341 ttcttctgcc cgccgacaat gaggagctgg tcgtcgcttg tttcgatatg atagcccatt 3488401 tctctcagct ttgccgttaa cgactcaaga tgagtaggga tgacgttatc gataatgact 3488461 tccttgccca ttgcagcccc tgcaatcata aatgtcccgg cttcaattct gtccggaatg 3488521 atcgtatgct tgcagccgtg cagttccttc acgccgtcga ttcgaatcac attggtgccc 3488581 gcacctttga ttttggcgcc catgctggta agcaatgtcg cgacgtcaat gatctcaggc 3488641 tccttggcag cgttttcgat gatcgttttc ccttctgcca aaacagcggc gagcataatg 3488701 ttaatcgttg ccccaacgct tacgacatct aaataaatcc gtgcgcctct cagcctttca 3488761 gctcgcaaat aaatggcgcc ttgttcattg gttacttcag ctccgagtgc ttcaaagcct 3488821 ttgatatgct gatcaatcgg acggggccct aagtgacagc cgccaggcaa tccaatgacc 3488881 gcctgcttga agcggccgag catcgccccc attaaataat atgacgcgcg aagctttttt 3488941 actttcccgt taggaagcgg catgctgatc atcgacgtag ggtcaacaac catttcccca 3489001 ttctcaaaat gcacgttgcc gccgatttcc tttaacaggt cacgcagcgt ttcaatatct 3489061 gaaatctctg gaagcccttc aattgtcacc tcggaatttg ccaaaatggt tgcaggtatt 3489121 aacgcaacag cgctgttttt agcgccgctg atatgtactg taccgtttaa cgagtcaccg 3489181 ccggcaatat tcaacttttc catgatagtc tccttccata agaagatagc tgcggagcta 3489241 aataaaatgt cattttattc tgtctctgca aataaagctc atgtccaaaa tctagccaat 3489301 tcgaagagaa agaatacaac acattgtaaa atatcaggaa gaaaatagcg aagctttggg 3489361 gggtacaggt ttcaaaagat gcacagagac ccgccggctc gagagacatc gtcgtcatcc 3489421 ggcaaaagca gtacgcatac ccttcattcc gatatcagct tctgcagccc aatgattcct 3489481 tctctgtaaa gcggcgtcag catctgaaga tccgctgtat caggtcggtg aaatacaaag 3489541 gccgcggcaa acaggcataa agctgtttgc cgcccctttc attatttgtt ccagtctgcc 3489601 aggaattgtt cgattccttt gtctgttaac gggtgtttag tgagcgcatg aatgactttc 3489661 agcggcattg tgccgatatg agcccctcta agagcagctt ctgtcacgtg ctgcggatgg 3489721 cggattgacg ctgcaatgat ttgcgtgtca aggccgtgaa tgtcaaaaat ctgtttaact 3489781 tctgaaatca ggtcaagccc gttgtggccg atgtcatcta aacgtcccag gaatggagat 3489841 acatatgttg cccccgctct ggcagcaaga agcgcctggt tggcattgaa gatcaatgta 3489901 acgtttgttt tgatgcctaa gtcagtaagt gctcttaccg cttttaaacc gtcagacgtc 3489961 attgggattt tcaccgtaat gttcggagcg atcttcgcca gttcttttcc ttcctcgatc 3490021 atttcctcag ctttcaaaga aataacctct gcgcttacag accctttcac gacgtctgtg 3490081 atctcgcgaa gacggtcgtg gaatgatacg ttagcttcct ttgctactaa actaggattc 3490141 gtcgttacac cggcgagaat tcctaattca ttcgcttctc taatttcatc gatattggct 3490201 gtatcaacaa agaataacat tttcaaaaag cctccctgat taagaaattt tctgaactgc 3490261 gaatatgatt gcgctttcta aagatagacg gaaaaccgcc tgtcaagctg tcaggcggct 3490321 ataaaaagtt ccaattgaat taagcttggt ttgaagaacc aaattcacgc attttaccga 3490381 taactgtttc tttgatcgct tcacgagctg gtccaaggta tttacgtgga tcgtactcgt 3490441 caggcttagc tgccaatgtt tcgcgaacag cttttgcaga agaaatttgg ttttcagtat 3490501 tcacgttgat tttagctgta ccaagtgaaa ttgatttttt gatgtcagca gtcggaattc 3490561 cagtaccgcc gtgaagaact agcggaaggc cagttgattt tccgatctct tccatttctt 3490621 tgaagccaag gtttggctca cctttgtaag ggccgtgaac agaacctaat gcaggtgcaa 3490681 ggcagtcgat gccagtgcgc tcaacaagct cttggcactc tttaggatca gcgtagatta 3490741 cgccttcagc gataacgtca tcttcttgtc cgcctactgt tccaagctca gcttctacag 3490801 atactccgtg gaaatgagca agctcaacaa ctttagcagt tgttgctacg ttttcttcaa 3490861 atggatggtg agaagcgtcg atcattacag atgtgaaacc tgcatgaatc gctttcgcac 3490921 aagattcaaa gcttgaaccg tggtctaagt gaatcgcaac aggaactgtc actttgtact 3490981 cttccataag tgcttttacc atagcaacga ctgttttgaa gccgcccatg tagcgtcccg 3491041 caccttcgga aacaccaagg atcactggag atttttcttc ttcagctgct tgtaaaatcg 3491101 cttgagtaaa ctcaaggttg tttaagttaa attgtcctac agcgtaccct ttttctttag 3491161 ctgtattcaa catttccgtc atagaaacta aaggcatgtc gaatgtcctc cttatgtagc 3491221 ctgattgtct tctagcgaaa aaagctttcc accctagcat gacccatata ttgctgtcat 3491281 atgtaaatac tcagatcgct ttttctccat aactaggata ccaacttttc gacaaatcgg 3491341 caacataatg acatgattca tttgtttctt ctttttgtca gttagacttc aggggcagat 3491401 attttttgac ggcgtctctg atttcgtcga tgtcaaacgg cttggcaaag tgcgtcagag 3491461 cgcccaattc cttcgattcc tggatcatgt cgagctctcc gtatgccgtc atgataatga 3491521 cccggatgtt ttcgtcaatg accttcatcc gttttaagat ttcgattccg tccatgccgg 3491581 gaattttcat gtccaacagc acaaggtcgg gccgttcttt tgtcacaatg tcaagcgcct 3491641 gcaggccgtt cgcagcctga aacgtctggt agccttcttt attgaacact tcatttagca 3491701 aaatacgaat gccgtattga tcatcaacga ttaaaatttt ttcattcatc attttacacc 3491761 ccaatattat gattttcgtc aaaagtaagc agtattgtat gtattctgtt tgattttcct 3491821 atttccttta attataatag tctactttac gacattttct gagcattttc tcttttgttg 3491881 tatactgata ttgtacgtta taaaggagga ttcacttatg ttgaaaatat tcacgacgca 3491941 gttaacaggt attttttccc gcattcagga taaggaatct gacgcgattg aagatggggc 3492001 gcggctgctt gctcaagcgg tgatcagcgg gcattccatt tatttatacg gagcgaatga 3492061 gcttcagggc gtcttttatg aggccaccga aagcaaagaa cccttcccat ctgtcaaagc 3492121 ctttccagaa aacgctgagg aagtgacaga aagcgacagg gtgctgatgt tttgctcagg 3492181 gacgggcaca gccgaagaac aggagctcgc aaaagagctt tatgaaaaag gtgcgggagt 3492241 cgtatgcgta tcgcccgcag ccaaagacag tgcgggaata gaacagtatt gtgatgtgca 3492301 tattgattct aaattaaaaa tgccgcttgt tcccgatgaa gacggcaccc gttacgggtt 3492361 tccctcttta atgacagcac tgtatgtcta tcacgcttta tcgtttacac taaaagaaat 3492421 tctgcaagag tatgcataat atcttattgt acatgctgga acttgccgga aacaaataaa 3492481 aaagacttgc ccgcttttga caaacggcaa gtctttttta ttacttctga tttgcagctt 3492541 cgacagacgc tccgataaag cctttgaata gaggctgagg tcttgtcggt cttgacttga 3492601 actctgggtg gaactgagaa gccacgaacc aagggtggtc tttcagctcg atgatttcaa 3492661 caaggcgtcc atcagggctt gtgcctgaga atacgaagcc ttgctcttcc atttgctgtc 3492721 tgaattcatt gttaaactca tagcggtggc ggtggcgctc gtacaccact tcatcctgat 3492781 acacttcaaa ggctttcgtg ccttcttcaa gcttacaagg gtaaaggccg agacgaagcg 3492841 ttcccccaag atcctcaaca tccttttgtt caggaagaag atcaatgatc gggtattgag 3492901 ttgacggatc aatttccgct gagtgagcgc cttttaagcc caatacgttt cgtgcgtatt 3492961 caatagacgc cacctgcatg cccaagcaaa tgcccaagaa cggaatgttg ttttcgcgcg 3493021 cgtattttgt cgcgacgatt ttcccttcaa caccgcggtc tccgaatccg cccggcacaa 3493081 tgatgccgtc tgttccgctt gtgagttctg cgatattgtt ttctgtcact tcttccgcgt 3493141 tgatccactt cacttttaca tctgtgtcaa acgcatagcc cgcatggcgg agagactcga 3493201 caacagaaat gtatgcgtca ggaagctcaa cgtatttgcc gacaaggccg attgtaatcg 3493261 tttgagacag gttgctgact ttgttaacaa gctctttcca ctcggacatt tccgcttctt 3493321 tgcatgccaa tttcatgtgc tcgcaaacaa gcttatcaag cccttgtttt tgaagctcca 3493381 gcggaatgga gtaaaggttg tccgcatctt cacattcaat aaccgctttt gtatcgatgt 3493441 cgcagaaaag cgcgatttta tctttcatat cttgagaaat cggcatttct gtacgaacga 3493501 cgatgatgtt tggctgaatg cccaagctgc gcaattcttt tacgctgtgc tgtgtcggtt 3493561 ttgtttttaa ttcgccagca gctttaatgt aaggcacgag cgtacagtgg atgtacatta 3493621 cgttttcacg gccgatgtcg ctcttcattt ggcggatcgc ttcaaggaat ggcagtgatt 3493681 cgatgtctcc gacagtaccg ccgatttctg taatgacaac atctgcgttt gtctctttcc 3493741 ctgcgcggta aacacggtct ttcaattcgt ttgtgatgtg cggaatgacc tgtacggttc 3493801 ctccaaggta atctccgcgg cgttcttttt taagaactgt tgaatagatt ttacctgttg 3493861 tcacgttgct gaatttattc aggttaatgt cgataaaacg ctcatagtga ccaaggtcca 3493921 agtctgtttc agcgccgtca tccgttacga atacttcacc gtgctggtac gggctcattg 3493981 ttcccgggtc aacgttgatg tatggatcga atttttgaat cgtcacgttc agtccgcggt 3494041 ttttcagcaa acgccctaat gaagctgcta caataccctt tccaagtgag gatacaactc 3494101 ccccggttac aaaaatatat ttcgtcattt cgtttgctcc tctcttcgct cttagctaca 3494161 tttttaaaat gtactatttt ataaaaaatc atttagcctt ttaaatgatt tataagaaaa 3494221 atgaggggtg aaaataagaa agctcccttt caatttcttg aaagggagca taacgtacta 3494281 tgttctctct tcgtttttga agagcccaaa atacatacta catagttcga ctatgaaagt 3494341 caagatcgtt ttgaagatga aatctgatac tatttaattt cctcttcttc atcatcatag 3494401 tcttcatcat cttcatcaat aatatcttct tcgatctcaa gatcatcgtc gtcttcatca 3494461 agatcttctt cgtcaaaatc gtcggcttca agatcgagtt cttcctcaac ttcatccaaa 3494521 tcaaggtcgt cttcgtcgat ctcttcaaac tcgtcaagat caagatcttc ttcgactgct 3494581 ttcttcgctt ttttcttttt cgccttgact gtcggctgag tttcttcatc aagctgatca 3494641 taaggatacc agctgcgaag cccccacgtc tggtcagaaa gcgccaggaa gcggccgtca 3494701 atgtttaaat ctgtataaaa ttgagcaatg cggtctccaa gctcttcttt tttcacgccg 3494761 agcaaagatg cgatttcatt taaaagctcc tgaaaaggaa ctggtttttt atgttcttca 3494821 aataattcgt gagcgatttc aactaaagcc atttccttta gctcttcctg tgaatattgt 3494881 ttgataccca aggtcggaca ctccctttct attacttata tgtatctgtt ttatcaataa 3494941 tgaaagcgat tttgtatcgt tcttatacaa accatacctc tcattataaa caaaataaaa 3495001 cagaatatgc tacccttaac agcgttaatt taaataattt tacaagagtg atccgactga 3495061 gagatgtttt ccgttaatcc gcgagcattc tggagatgac cagtctttga atttcttgag 3495121 tgccttcata gatttgcgtg atttttgcat cacgcatata gcgttctacc ggataatctt 3495181 ttgtatagcc gtagccgccg aaaatctgca cggcttcggt cgttaccttc atcgccgtat 3495241 ccccagccat cagtttggac atggcggaag cttttccata tggaaggccc gatgattcta 3495301 accatgcagc ctgataggtc agtagccttg aagcttctat cattgtcgcc atatccgcga 3495361 gtttaaaagc gatgccctgc tgctcggcga tcgattttcc gaattgcttt cgctcttttg 3495421 catattgaag cgccgcatca agcgctcctt gggcgatgcc tacagcttgt gcagctatgc 3495481 cgtttctgcc tccgtcaagc gtcttcatcg cgattttgaa gccttctcct tcttctccga 3495541 gacgctttga tgcgggcact acacaatctt cgaacatgat ttccgttgtc ggtgaagaac 3495601 ggatgcccag cttcttttct ttcttgcctg taaaaaatcc ttcaaaatcc ttttctacta 3495661 taaaagcggt aacgcctttt ttctttttct cgggatcggt gacggcaaaa acaatgtaaa 3495721 tatcagcaac gccgccgttt gtgataaaca ctttggaacc atttaacaca tagtcatcgc 3495781 cgattcgttc agcagttgtt ttcatgctgc cggcgtcaga gccagaccct gcttcggtca 3495841 aagcgaatgc gccgattttc tctccgagag ccagctgtgt taagtactct gtcttctgtt 3495901 cctctgtccc aaaggcaaac agcggccagc tgcaaagaga gatatgggcg gaaagcgtca 3495961 caccggtgga ggcgcacact tttgacagct cttccaccgc gatgacgtag gctaaatagt 3496021 cacttccaat tccgccgtaa tcttcaggcc atggaattcc cgtcaggccc agatttgcca 3496081 tttcccgaaa cagctcgcga tcgaagcgtt cttgttcgtc ccgttcagcc gctgtcgggg 3496141 ccacctcatg cttcgcaaaa tcgcgcacca attttcgtat catctcatgt tcttctgata 3496201 atgaaaaatt cattgcttct cccccatttt cagatcagcg cctaaaacgg attgagccag 3496261 aagctcgacg acgtcgtacg ttttgacttg gtcttcggct tccttcgcct ttgtgccgtc 3496321 cccaagcatc gtgagacaat acggacagcc agaactgatc accgatgggt tgactgcgag 3496381 cgcttgctct gtcctggcga cgttaatcct gttgcctgtt tcttcctcca tccacattaa 3496441 tcccccgccg gctccgcagc acatgccggt ttcccggctt ctctccattt caacaagctg 3496501 cacgcccgga atggctttca aaatctctct cggcggatca tagacttcat tgtaccggcc 3496561 caaatagcac gaatcatgga aggtaatcgt ctcatgaagc gggtgctgcg gtcttaattt 3496621 tccgtttttc acaagctcgg ccagcacttc tgtatgatga taaacctcgc cttcaaatcc 3496681 gaaatccgga tattcgtttt taaataaatt gtatgcatgg ggatcgatcg taacgatttt 3496741 tttgacatca tttttttcaa attcagaaat attcttctca gccagctctt ggaacaaaaa 3496801 ttcatttccg aggcggcgcg gcgtgtctcc tgaatttttt tctttattgc cgagaatcgc 3496861 gaaggacacg cccgcgtgat tgagcagctt ggcaaaggaa attgcgattt tctggcttct 3496921 gttgtcgtaa gaccccatgg agcctaccca gaaaaggtac tcaaattctt ttccttcttt 3496981 tttcatttct tttacagtcg gaatctcagc atccggcgcc tcgtcacgcc aattttcacg 3497041 ttccttgcgg ttgagtcccc acggattccc ttgccgctca atacttgtca ttgcgcgctg 3497101 ggcgtcactg tccatttttc cttctgtcag tacgaggtag cggcggaggt cgatgatttt 3497161 atccacgtgc tcattcatga ccgggcattg atcctcacag ttccggcaag tggtgcatgc 3497221 ccaaatttct tcctctgtga tgacgtcgcc gatcaagctt ggattgtaat caagcgccgc 3497281 tgcggcttcc tgcgatccgc tgcccgctga cgccgcagcc agctgattgc ctctcgtatg 3497341 ccgaaacgct gctgcgggca cccatgggga gcgcgaggtg acggcagcgc ctttttccgt 3497401 gagatggtct ctgagacgca aaatcaagtc catcggagaa agcatttttc cggtgcctgt 3497461 tgcaggacac atattggtac agcggccgca ctcgacacac gcgtatagat caagcagctg 3497521 agactgtctg aaatcctcaa tttttcccgc tccgtagctt tctttcgttt cgtcggtaaa 3497581 atcaattttt tcaagttttc cggcagattc cattcgattg aaaaagacgt ttgccgggcc 3497641 ggcgattaaa tgggcatgct ttgactgagg cacgtacact aaaaagctaa gcaagaatag 3497701 gagatggatc caccatgcga tatagaaaat caccgccgcg cctgttttcc cgacaccgct 3497761 aagcataaac gcaatacctg aggcaattgg ctcgctccaa gaaagcccat gctcatgcca 3497821 aatcagattc atcccgttcc caagcagaac ggtcagcatt aatcctccga taaaaatgag 3497881 aacgagtccg gctttgaaac cgcgtttcag cctcacgagc ttttcgatat aacgtctgta 3497941 gaatgcccac ccaacagcaa ttaaaatgag aaacgtaaca atttcctgaa aaaaggtgaa 3498001 ggcgggatag accgggccaa gcgacagatt ccggccggga gccagtcctt tgatgataaa 3498061 gtcaattgct ccgaactgaa ccaatataaa tccgtagaaa aacatgacgt gaatgattcc 3498121 gcttttcttg tccttgagca gttttttctg tccgaataca ttcacccata tggcgtgaag 3498181 ccgttccttg aaccgttgat caaattgttc tttctggccg agcttgatgt aggccagtct 3498241 cgttttgacc aagtaaacaa acaaatagac agcgtaagcg gttacaatca gaaataataa 3498301 tgcatttgcg atgagaaagc cgctcattcc aattccccct ttttactgat aaagaccgcg 3498361 atcccctacc cccgaatctg tataagatta tctttatgat aaataatgaa tgagtgttca 3498421 gtcaataatt aaattcctgc tgttcgggca cactaccttt actacggaaa ggagtgccgg 3498481 tatgaaggta tttatcgtga ttatgatcat tgtcgttatt ttctttgcct tgattctgct 3498541 tgatatcttc atgggccgtg ccggatacag aaaaaaggcg tacgagcctg ttttttcaaa 3498601 aaagaagagt gacatcgaat tgatccactg cggcgctgat ctcgttgagc ggatgatgaa 3498661 tgatattcgc caggccgcct cttctgttca catgatgttt tttattatga aaaatgatga 3498721 ggtcagccac aatatgtata ccttgctgaa aacaaaagcc caagctggcg tatccgttta 3498781 tttgcttctg gattgggcgg gctgccgggc aattaaaaaa acggcgcttc agacgatgaa 3498841 aaatgccggc gtccatgtcc atgtgatgaa tcgtccccgt tttccttttt tcttttttca 3498901 catgcaaaaa cggaatcacc ggaagattac ggtgatagac ggaaaaatcg gttatatcgg 3498961 cgggtttaat atcgccgaag aatatcttgg aaagaaggcg aagttcggca attgggagga 3499021 ttatcatctg cgcatgatcg gagaaggcgt acatgatctt caaacgcttt ttgcttctga 3499081 tctaaaacga aataccggaa tcgaactggg ttcggatgtt tggccaaagc ttcagcaagg 3499141 gactatttct cacaagatct atgcgaccga cggttattcc cttgaaaaca tatacttggc 3499201 caacattgcc caagcgaaga atcgccttac ggtttgcacg ccttattaca ttccatcaaa 3499261 accgcttcaa gaggccctta ttaacgcaag aaaaaacggc gtatccgtga gaatcattgt 3499321 accgatgaaa tcagaccatc cgctggtacg agaagcggct tttacgtatt attcggagct 3499381 cttggatgcc ggctgtctta tttatcgtta ttatcaaggg ttttatcatg taaaagccct 3499441 catcatagac gaccatctca gcattatcgg aacagccaac ttcgataaac ggagcctgtt 3499501 cttaaatgaa gaggtgaatg ttgaaattga tgacgaagcg tttacaagtg aagtctatgc 3499561 cacaattgag gaggatatga aaaagtcgga gctgctgacg atggaggatt tcagcaagcg 3499621 cacattcagg cagcgcccgg cggaatggct cggcagggca ttatcttatt tcttataaag 3499681 gagagttcct atgattttca gattcgggtt cgtttcaaat gcgatgagcc tttgggatgc 3499741 gtctcccgct aaaacattga cattcgcgcg ttattcaaag ctttcaaaga ctgaaagaaa 3499801 agaagcgctt ctgactgtga caaaagccaa tttgcgcaat acgatgagaa cccttcacta 3499861 tatcatcggc cacggcattc ctttgtaccg tttttccagt tcgattgtgc cgctggctac 3499921 gcatcccgac gtgatgtggg attttgtaac accgtttcaa aaagagtttc gggagattgg 3499981 agagcttgtt aaaacccatc aactgcgaac aagctttcat ccaaatcaat tcactctgtt 3500041 tacgagcccg aaggaatccg tcacaaaaaa tgcggtaaca gatatggcgt atcactaccg 3500101 catgcttgag gccatgggca ttgctgatcg ctccgttatc aacattcata ttggcggcgc 3500161 ttacggaaat aaagacaccg ccactgcaca atttcatcaa aatataaaac agctgccgca 3500221 ggagatcaaa gagcggatga cacttgaaaa tgatgataaa acatatacaa cggaagaaac 3500281 gcttcaggtc tgtgagcagg aggatgttcc gtttgtcttt gactttcatc atttttacgc 3500341 caatccagac gatcacgccg acctgaatgt agcactgccc cgcatgatca aaacgtggga 3500401 gcggatcggc cttcagccaa aggttcactt gtcttcccca aaatcggagc aagcgatacg 3500461 cagccacgcc gattatgttg acgccaactt tttgctgcca ctgttggaac gctttaggca 3500521 atggggaact aatattgatt tcatgattga agcaaagcag aaagacaagg cgcttctccg 3500581 cttgatggat gaattaagct ccatccgcgg tgtcaaacgc atcgggggcg gtgcgctgca 3500641 atggaagtca taaatgtgca aaaataggtt tacgacttgt cagctttggg aacttaggct 3500701 atataagaca acaatcgatg gaggagaaag atcatgaaaa atatcaagtc tctgaaagta 3500761 gccgcacagg cctttacttt aagaaatttg attcatcttt ataaaatgtg ccattccgga 3500821 agccacgagg tttatattta ttcaaagaaa acgatgtgca aaatcaaaag cttaattgag 3500881 cttgaaacgt tccgcatggc tcataatgaa aaggaatatc tgatcgtagt tgaaggaaca 3500941 aaagcatcac agctcattga aaaattccaa aatctcatcg agcctgctga gagagaagcg 3501001 ctctaactta catacaaaaa aggatagaca tctgtctatc ctttttctta tgctcttaca 3501061 taatggagct gaaccgcttg tccaaattgt tttgtccctt ttaaccgcag ttttgtttca 3501121 tttgttagtt cgtgaaacag cgggatgccg cttcctaaaa cgacgggaat aacagtgatg 3501181 atgaattcgt cgatggcatc ttctttcata aagtcattca caagctctgc cccgccagct 3501241 atccagatgt ttgagccttt ttcctgtttc aaacgggcag tgaaggctct ggctccctca 3501301 ttgataaacg tcacatgttc atcttgataa ctgtcgggcg atcctgtaaa aacatagcag 3501361 gttttatcct gatacgggaa aaccggtgtt agcactttaa cgtgctcata tgtgctccgc 3501421 cctaaaatga ctgtatcaac agtctgataa aaatcactgt agccgttgtc accttcacct 3501481 tcaaattcat ccagccaatc gatgcttcca tcttcttttg cgatcatccc gtccaatgaa 3501541 acagcaatgt acagcacagt ttttctttcc atgttctcct cctatcgatg caccatttgc 3501601 ccgaattgcg cttgatgcag cctgctgtat aggcctccgg cttcgatcag gtcttgatga 3501661 cggccttgtt cttcaatacc gttgtttgtg acgactacaa ttctgtccgc gtctttgatt 3501721 gttgccagcc tgtgggcgat gacaagcgtc gtgcgcccct cagacaactc ttgaagcgcc 3501781 ttttggatcg ccgcttccgt ctctgtatca agggctgagg tggcttcgtc gagaatcaag 3501841 atcgacggat ttttcaagaa catccttgca attgacagac gctgtttttg cccgccggaa 3501901 agcttcacgc cgcgttcgcc aatcatagta tccaacccat cgggcatgtt atggacgagc 3501961 tcttccagat gcgcctgctt cacagcttgc caaatgtctt cttctgatgc gcctagtcgg 3502021 ccgtaggcga tattttctct aagcgtgccc gagaataaga aaacgtcctg ctgcacgacg 3502081 ccaatctgcc cgcgcaacga agaaagcgtc atgtctttta tactgatgcc gtcaatcgta 3502141 atgtcgccct ccgatgcttc ataaaaacgc ggaagcagac tgcaaagcgt tgatttccca 3502201 gcacctgacg gaccgacgaa cgccaccgtt tcccccgctt gaatggatag gttgatgtca 3502261 ttgaggacat tgtgatggtc atcatagcca aacgaaacat gtttatagcg gatattgccc 3502321 ttcaggccgg aaacatcttt cgaatcaggt gagtcctgaa tatccggctc tgtctccatg 3502381 agctccatat agcttttgaa acccgcgatc cccctcggat acatttcgat aatggcatta 3502441 attttgtcaa taggcctgaa cagcacattc gtcaagagta caaacgccac aaattccccg 3502501 tacgataagg agccgcgaat gacaaaccac gtcccgcaca aaaggacaaa cagcgtgaca 3502561 aaccgggtca gcatatagct gattgaaccg tttttcgcca tgattttgta ggaagaaagc 3502621 tttgtgacac gaaaacgctg gttgttgacg gcgaagcgtt ctttttcaaa tgcttcattt 3502681 ccgaacgcct gcacaagccg gatgccgccg atgttatttt ctacacgcgc gctgaagtct 3502741 ccgatatcct tgttcagcgt ggtaaatgct ttggtcattt ttttgttgaa ataaagcgct 3502801 agccaaatga cgatcggcat aatgataaac gttaataaag caagctgcca gttaataaac 3502861 agcatcactc cgaacgcccc gagaatggtc atgaccgcaa tgaataagtc ttccggtccg 3502921 tgatgggcga cttcaccgat atacattaaa tcgttcgtga gcttcgacat cagcgttccc 3502981 gtcttgttgt tgtcgtaaaa tttgaacgag agcttttgca aatggtcaaa aagcgacttt 3503041 ctcatatcag tctcaatatt gataccaagc atgtgtcccc agtaggtcac gatatactga 3503101 agagccgagc tgagcgcgta caccgcaaat aacccgattg aggtcgcgat gatcagtccc 3503161 cagtccctgc ccggcagcaa ggtatcaata aaataattga cgatcaaagg aaaactcagc 3503221 tccattaaac ctcccgcgat cgctgagaaa aagtcgagaa agaacaacgt tttatatggt 3503281 ttataatatg aaaaaaattg ccgcagcacc ctatcttccc ccaatgtata aataactgat 3503341 aatatttctc aattatacta tacacgggct gttttgtaag atcagatttc ttttttctta 3503401 cagaacacct gaaaacaggc gggcaaacga ctcttttgtc cggtcagcca cacctctttt 3503461 ataaaagccg acagggctga gcttttcact ttcctgcata tcctcttcaa aatgggcctc 3503521 aagggttcgg atcgcttcgg catccgtgaa gaacacattc acttcaaagt tgagctgaaa 3503581 gctgcgcatg tccatattcg cggtaccgac ggaggcgaga tcgccatcaa tgatcatgac 3503641 tttttgatgc atgaagcctt tttggtagga gtacacttca atgccctcaa ggagcagctc 3503701 cgggaaatag gacctcgacg cgtattgggt caaaaagctg tcgttcttct ccggcaccat 3503761 aacccttacc tctaccccct ttgtcgccgc tgcttttagc gccgtgcgaa tggattcatt 3503821 ggggacaaaa tagggcgtgg cgatccatat tgatttctgc gctgaagaaa tcatttcata 3503881 ataaaggtcg ctcatgcttt ccttcatgtc agggcctgtc gcgacaattt gataaatgcc 3503941 tcctccttcc acgggaaccg gggtattgta ctcctcttga tcaattagca cttcattgga 3504001 gacatattcc caatccagca taaagatagc gtggagcgtt tgcacaattt ccccctcaag 3504061 ccgcaggtgt gtatctctcc aaaatccgat gtacggatct ctgctgatat attccttccc 3504121 gacatttaat ccacccacaa aaccggtttt cccatcgatg atcacgattt tccggtgatt 3504181 tctgaaattc agcttctggt tgaaaaaccc gtatttcagc ggagaaaacg ggacgatgtc 3504241 cacccccgct tgtttcattc tcataatatc tcttcttgcc agcttcatgc ttcctgccgc 3504301 atcgtataaa aacctcacct cgacaccctg gcgcgctttc tccatcataa tatccatcat 3504361 gccgcgtccg agcatgtctg atttaaacat gtagtattca atatgtatgt aagattccgc 3504421 ttttctcatt gctttgaaaa tgtccgggaa ggtttcttcg ccgtttttca gcactttgat 3504481 gttgcttttc gtattgatat tcatatgggc agccctgatg gaatatgtaa agaacctctc 3504541 ttgattgtcc ttcagccctg tcacttcggg cgtttcctcc ttgtcaaaca gcttcctgag 3504601 cttttccctg ttgtacattc gttttgtctt aaacagcttt ccctttacat aaagctgtcc 3504661 cgaaaacaga taaaacacgt agccgacgat tggaaaaaag acaagaatat ggatccatag 3504721 cagcgtgtgc tgcgaggtgc ggttttcaag aattaatgaa tagatgctga acaaaataat 3504781 gcttatatag caaagcaatc ctccgtaaaa ctcaagtctg gaaaccggaa aaaaccaaat 3504841 gacatatgcc ccgatgagca tcatatataa aaagaaaaat tccagtctcc ttttcagcat 3504901 cctgattctc tccaatctga ttcaattacc tctgtattac ctcttttttc taatcgataa 3504961 accttgtaag taaaaaacct ctccgccaaa ggaggagagg tttagagaaa actaactgtc 3505021 acggaattca tccgcatcgt ttctgcagaa ataaagcaag actattggca acgccgagtg 3505081 acaacatgag cggcaagctg aacccgctca gcactccggc aagcgccgaa aagaaggcgg 3505141 cgctgtgact gcaaatacgg tggatagagt aaatttgata cccattctga tgagagaaaa 3505201 tatataaaac gggaaattga tcagaaagat ataaggagtt agtcaggctg aatcataatc 3505261 tggctgttcc gccggtttaa aatgagtaaa atccttgatg ttatttccat atacaaacat 3505321 aacaggattc ccggcagccc agccattacc ttggcagaaa aaaccccctc ttgcaagggg 3505381 gattttcacg agcgtttccg atatacaacg tagctgcggg tcagatactt gagcggcaga 3505441 ctgaacacat gaaccaatct cgtaaacggc cacaggataa aaacgacgta tcctatcaca 3505501 atatgaaact taaaccatag cgggacactc tccatcaaag aggcgtcagg cctgaacaaa 3505561 acgatttccc tgaaccaggg cccgactgtg gtccggtaat caaatccttt cgaatcaatg 3505621 ttgagaaacg tggccgcaac gcctgacagc atcatgaaca gcagcaggag gagcgtaagg 3505681 atatcggatg gcgagctcgt tttgcggatt cttttgtcaa acagccttct gtacgtcagg 3505741 atgacaagtc cggtacatgc cgcaatgccc gccggcaagc cagcgccaat cgccattttg 3505801 tgatacatat gctctgaaat gccaagggaa gcatacacgc cttctgggat cagaatcccc 3505861 atgacatgcc cgccgacaac gcacagcagt ccccagtgaa aaagtgtgct gccagccgca 3505921 agttttttct tttctaacag ctcgcttgat ttcgccgtcc agccaaattg gtcatgctga 3505981 tagcggtaaa tatggccgcc gataaagatt gtcaatacaa tgtatggcat aataccccag 3506041 aggatctgcc cgctcatgcc tgaacagccc cttcaacgct ttcacgtacg ccaatgtttt 3506101 caagcgcggc cagcagcacg tgcagcagtt cagcgtatat actgtcattt ttttcgagac 3506161 gggatgccag ctccctcaca ttggacagat atttctcaaa cacgcttctc gctgcttcaa 3506221 tttctgcagc cgcagcaaat tccagcatca gcggcagata atcaggcagc tctttctctg 3506281 tcggcaggaa accggattgc tcgtatgtgt tttttaaatg cagcaattca atgccgcgtt 3506341 ccctttgctc gcctgagtta aagtaggtga catacatatt tgtttttttc ccgaagtcga 3506401 atgtatagac atagtgttca atcagcgctt ccggagaata gctggctgac gtctcgaaaa 3506461 agtgcagcag cttctcccgg atttgccggt tgccgatttc ttggataaga gccttccaat 3506521 cgggaagctc ggctctccac tcttcatccg gataagagag aagacaggaa agagcagaga 3506581 acgtgatttg ccggtctgtg gtgttcatct tgttacacct catttatcaa aagttagaaa 3506641 caggagccgg ggccgcctga aaatgataag ccgcagcttc cttgttcagc gtataaatct 3506701 gatacttctt ctcgatggct gctcggaatc acaaagcggt catcatattt ggcaatcgca 3506761 agcagccgat acatatcttc aatttgctgt tctgttaagc cgacactgga gatcagttcc 3506821 ggatcgattg atttattcgt ctggaccgct ctcatatact ggcgcatgac agacattttc 3506881 tttaatgttg accgaatatg atccgtatca ccggctgtta acagctgcgc caaataatct 3506941 atcgggattc tcatttggtc gatagccgga aaaatatctt ccgccgtttg ccggctgcct 3507001 tttccttcaa agagattcat aatcgggctg agcggcggaa tgtaccacac cattggcagc 3507061 gtgcggtact caggatgaag cggcagcgcg atcttccagt caatgatcat tttatagatc 3507121 ggtgattgct gcgcggcctc tatccattca gccggaatgc cttgttcttt tgccagtttg 3507181 gcaacctcag gatcattcgg atcaagaaaa acgtccaatt gggaatggta gagatccttt 3507241 tcattttcaa cagatgccgc ttcctccact ttgtccgcgt catatagcat gacgccgagg 3507301 tagcggattc tgccaacaca cgtctcagag cagatggttg gcagtcccgc ctccaaacgc 3507361 ggaaagcaga gtgtgcattt ttccgctttg ttcgtttgcc agttaaaata gactttttta 3507421 taaggacagg atgagacgca atatctccat gaacggcatg cgttttgatc cacaagcaca 3507481 atgccgtcct cctcgcgttt gtacatggcg ccggatggac aggatgagac gcatgccggg 3507541 ttgatgcagt gctcgcaaat acggggcaaa tacatcataa agacgtcatc gaattctgtt 3507601 ttgatcgatt cctccatctt ttgtacgttg ggatcttcaa gtcccgtaat gtggccgcct 3507661 gcgagatcgt cctcccagtt cggtccccat tcgatattca tgaaatcccc cgtcaaggac 3507721 gatttcgggc gtgctaccgg ctggtgtttt ttctgcgggc tgttcgttaa tgtttcataa 3507781 tcatagttcc aaggttcata gtaatcatca attgacggct gattcggatt atagaaaagg 3507841 cctgcaagcc gattggtttt cgagcccgat ttcagctcga gctttccttt tttcaatgtc 3507901 cagccgcctt tatatttgtc ctggtcctcc cattgcttcg ggtagccgat gcccggcttt 3507961 gtttctacat tattgaagta catatattcc gcaccggaac ggtttgtcca cgtgtttttg 3508021 caggtgacgc tgcacgtgtg gcagccgatg catttatcca agttcatgac cataccgatt 3508081 tgcgctttaa tcttcaagcc aatcgacctc cttcagcttg cggatgacga cgttcaggtc 3508141 gcgctgattc cccgttggac cgtaataatt aaagccgtag ctgagctggg cgtagccacc 3508201 gatcatctgt gtcggcttga cgtgaatcct tgtcgggctg ttatgggtgc ctccgcggtt 3508261 attcgtcagc tttgtgccgg gcacgttgat gtggcggtcc tgggcatggt gcataaacgc 3508321 cattccttta ggaatccgat gagacaaaac ggctctcgcg acgacaacgc cgtttcggtt 3508381 gaagcattca atccaatcgt tgtctttgat atccgtgtcc tctgcatcat ctttattcat 3508441 ccacacggtc ggcccgccgc ggaacagcgt cagcatcggc agagaatcaa aatacatgct 3508501 gtggacagac catttattat gcggcgtcaa ataattgagg acgatttctt ttccctcttg 3508561 atcaggccgt ttgctcagaa acgggcgatg ctggaggatc ggtttgaatg tcgccatcgt 3508621 ttcaccgaat tccatcatca gttcatgatc gacataatag gattgtctgc ctgtcagcgt 3508681 ccgccacgga attaattttt caacattcgt tgtaaacggc gaatacctgc gccctccttt 3508741 ttcagagccg gtaaacgctg gagacgtgat caccgttttc ggctgggctg taatttgttc 3508801 gaacgtaaag cattcttcct cgcgttcttc cgccaggtct ttcagcttca ggttcgtgat 3508861 gttttcaagt gattcccatg cttttactgc gacctttcca ttcgaagtgg atgatagggt 3508921 taaaatcgct tctgcagcct gctttgcttc acttatattt ggacatccct ttgccacgct 3508981 gtccgaggtg atttctccca gtctctgttt gagtgattca tattcatcgg ctattgacca 3509041 gctcatccct tttgttccgc tcggctttaa agcaacgttc ggaccaagtg cagtcatttt 3509101 atgaaaaatg tgtttgtaat cccgttcaac gacttggatg ttcggcatcg tttttcccgg 3509161 aatggcttca cattcgcctt tgctccagtc attgattttg ccgaatggct gggccaattc 3509221 ctgcatggtg tcgtggagca gcggtgtcgc aaccacttct ttcaccggct ccatatcgac 3509281 ttcttctgcc agatcggaaa cggcttttga cagcgccttg aaaatatccc agtctgactt 3509341 cgattcccac ggagccgaga tcgcaggagc aaatggatga atgaacggat gcatatctgt 3509401 gctgctgaga tcgtgttttt cataccatgt cgccgccggc agcacgatat cggaatacag 3509461 cgccgtaccc gccattcgaa aatcaagatt gattaataag tcgagctttc cttccggcgc 3509521 ctgctcccgc catttgattt cttctgggcg gatgctgtcg ctgtcgtcat tcattaaacc 3509581 gttcgttgtc cccagcaaat gcttgagaaa atattcatgc ccttttcctg agcttgagat 3509641 cagatttgcc cgccatacaa agagattcct tgggaaattc acttcattgt caggatcttc 3509701 aatcgcgaat ttcagttttt tctcttggag ctgtgaggcc acgtacgcac ctacgtcttc 3509761 aggtgttgct gcccctgctt tttcagcttc tttatacaga tcgatgccat tttgattgaa 3509821 agtcgggtaa gacggaagcc accctagccg cgccgccagc acattgtaat cagcgtggtg 3509881 cttgtagcgg gatgaagcag caatcggtga tgccaaatca ctgatcggct ggtcctcata 3509941 acgccactga tctgtcgcaa agtagaaaaa tgaggtgcca ttttgcagct tgggcacgcc 3510001 ttcccagtcc tttgcagttg caatcgtctg ccacccttca gcaggtcgga gcttttcctg 3510061 ccccacgtaa tgggcccagc ctccgccgtt tacgccttgg gcgcctacaa gtaaaacaag 3510121 atttaacact gctcggtaga tcgtgtcgga gttgaaccag tggttaatgc cggcccctac 3510181 gataatcatg gaccggccgt ctgtatcgat cgcattttgg gcaaactctc tggcaatctt 3510241 aacgacagct tcttttttga ttcctgtcat ttgttcctgc caggcaggcg taaacggctc 3510301 agggtcatca taggagacag ccgatcgttc gccgatgccc cggttcacgc cgtagttagc 3510361 cagtatcaag tcaaacacgg tcgtgatgta cgtttcttca ccgttcaggt tcattttttt 3510421 aataggaaga tcccgctcga gcactttgtt tccgtcattt gaaaaatacg ggatgcgcac 3510481 cgtgccgatt tcgtcctcta ttcccagcac agagagacgg ggttcaatcg gttccccggt 3510541 ttcttcatca atcatgtgca ggttccattt ctgctgcccg tcccagcgcg agcccattgt 3510601 cccttggggt atggcaaatg aacttgtctg ttcatcccaa accgcaggct tccactgatc 3510661 atgctttgtc ttccgcccga tgtccttcgc atgcagaaac cgtcccgctg tgtatacgcc 3510721 attttctttt gacagagtga cgagaaatgg aaaatcagtg tattgcttcg cgtactcaat 3510781 aaaacgttca gtttcttggt tcacgtaaaa ttcctgcaga ataacgtgac ccatcgccat 3510841 cgcaagcgcc ccgtcagtcc cttggcgaat actcagccag tcatccgcga actttgagga 3510901 ttccgcaaaa tctggactga tcgaaatgac cttagcgcct ttatagcggg cctccgccaa 3510961 aaaatgcgcg tcaggcgttc tcgttaacgg aacgttggag ccccatgtga taatatagcc 3511021 ggaattgtac caatcactgc tttccggaac gtccgtctgg tcaccccaaa tttgcgggga 3511081 tgctggagga agatccgcat accagtcata aaaactgagc atagggcctc cgattaacga 3511141 cataaaccgg gagcctgatg cgtggctgat catggacatg gccggaatcg gagaaaaacc 3511201 gacgtttcgg tcaggcccgt atttcatcac tgtatacagc agagaggctg aaatcagctt 3511261 cagcacctcc ggccattcag cgcgcacaaa accgcctttc cctctcgcct gtttatagga 3511321 cttcgctttt tcagggtttt cgacgatcga tttccaggct tccaatggat tttgatgcgt 3511381 ctgcaatgcc tcccgccaca aattgatcag cacaccgcgc acgtatggat atttcacacg 3511441 gagcgggctg tagatatacc atgaaaaact ggccccccgc gggcagcctc tcggttcaaa 3511501 atcaggcata tccgggcctg ttgatggata attcaaattt tgcccttccc acgtgactat 3511561 tccgtttttc acataaatat tccagctgca agaccctgta cagttgacgc cgtgggtgga 3511621 gcgaacgact ttgtcgtact gccatctgtt tctgtataca ttctcccaat cgcgatcctc 3511681 gcgggtagtt tggctatgtt tatttgaatg gtgttcgata ggagagaaat aattcaatct 3511741 cctaaacaac ggactccttt tctttttctt catgagagtt cactccttcc gagtcaggtg 3511801 atgctaagtt cactataaac agagacagcg tgtttccttg tgaactatgt cacacactct 3511861 gcttttttca caaaatgttc acacaaagga gaaggaaggc tgcgttcagg caggacgctt 3511921 gggtcattag ctgcctttca ttcaaagatc aaaaaaaacc ggctctattt aagaaccggg 3511981 ctcagcgttt tcatcctgtg atgtatgcag ataccgcaaa aataattgat aggaacaaaa 3512041 aacattttgc tgaagcatag ccaaaaagtt catttgcagc tgcggatgat aagacatcat 3512101 tttcttaaat atgtaatatg ggatgttgag aatcagaatg tctgaagtgg cattgactga 3512161 gataaagggc gataaataaa gcccgccttt ttcatcaatc ggaaacacat cgcctttttc 3512221 ccacagcgca acggttttcg acccttcagg gagccttgtg tccataaaac ggacactgcc 3512281 ttttaataca atataaacag attgagaatg aagaaaagat ggagactgat cacatgaacc 3512341 gcggataaac gtgccgtttt tcagcaaggt ttcgacaatg gatagaggca cttcattaaa 3512401 cataggaagt tgtttcagaa ataataaata gtcacactga ttcataggaa aacctcctgt 3512461 gctaaggata gctttagtgt agctcgactg agcctgtaca gcagtgatgt atttcacagc 3512521 ctgtatgatg aatgtcactt atcaggaggg tgaatgcatt tataatgaaa gaaaaaagga 3512581 ggatttcgat gaaggcgctg attccgaagc agcacggggc gtgggcgatg ctgctgatcc 3512641 catttttact cggcatggtc aagggaggcc ccgttatttg gcatattccg ctcttccttg 3512701 gttggctttt cctatactta gcggtttatc ccgttacgct tgccttaaaa aagaaacaaa 3512761 gcaaaccata tcaaaagtgg atgtgttatt acggttttcc cacctgctgc tttttgatga 3512821 tctcggtctt tcataagccg cctctcatct gggtgggcgt ttctttactg ccgctgtttc 3512881 tcatacatat gtattttgcc cgcagaaaaa acgaacgagc cttattgaat gatgttgcag 3512941 gtgtcttgtt cttttgttcg ggcgggtttg cgagctgctg gctggggatg ggaacccttg 3513001 acggctgggc ttggtttatt ttcttgcagt ctgctttatt ttttatcggg agttcctttt 3513061 atgtgaaatc ggtgatccgc gagagaaaaa acagggcatt tgcatactgg tcatggggat 3513121 atcacctgct gctccccttt ttatccgctc ttttcggagc aggatgggcg tttctcgctt 3513181 ttatcccgag cagcttgcgg gcatggtttt ttcatggaag ggattggccc gtaaaaacga 3513241 ttggcattct ggaaatcgtg aatgcctgct tctttcttgc cgtcatgtgc ctgtttatca 3513301 caaggtaaaa aaacaaggac accgctgtcc ttgttttttt cagtcaatat tgcaaatctc 3513361 cagcgggcaa ttttcacact caatctcaca tcgtaaatag tcccgcttgt gcaaaataat 3513421 ttttccggat tcgtctatcg aaataacccc ttttttgcgg agatctccga gcatacgatt 3513481 gacgctttcc cgtgcagccg cgcaaaactt tgccaaatcc tgatttgtca ggacaatgtt 3513541 aatcagaatg ccgtcgcttc gctccactcc gtagctgttt gataagcgga taagggtaga 3513601 atagagcgcc ccctttttgc catgaagaag cagatccctg attttggact gaatcttccg 3513661 gaggtgcgtg ctcatccatt tcatgaactc aaatgtcaaa gcgccgtttt ggattaattc 3513721 tttttccagc ttatttttat taatgacgag cacctcgcca tcctctagta cttttgcact 3513781 gagcatatac cttggttctt cagtgaaaag tgttaattct ccgacgatat catgcttttg 3513841 gcagattcta agcgtcaggt cttttccgtc agatgtcagc ttgccgattt caatgagtcc 3513901 tgattgaatc agataaagct cttctgcatc cattccttcc cgaaacaaat acgtgtgttt 3513961 ttccattttt cttttcgtgc tgatcgattc cagcaattca tacagatcgc tggatataag 3514021 atcactatca gatggtcgaa cagagagaaa attcatgagc tcacctcgaa gaaagtcacg 3514081 ttgtgtgttt attgtaacgt gaattgattt gtacccatcg agaaaaaact aacaatcttg 3514141 tgaatgcccc agtgttagtt gatgctctgg ctgtttctct ccgtgtgtgt tttcattctt 3514201 tcctgccaat acatccatat gacaaggaca aaactggcta acgccacctc tgaaagcgcc 3514261 ataaacccga tcgcgtactg gcctgttgcc tgaaatacac tcgccaatat gagcggagga 3514321 aaaaagccgc ctaaaccgcc catggcagac acaatcccat tggcaatccc cgcttgcttc 3514381 gaaaaataga aaggcaccag tttaaaaaca gttccgtttc ctatgcctga gcagacggcc 3514441 acggttaatg atccaaacgt ataaaggccg attgtcggcg agaacgatag gataatgcct 3514501 gataatgtaa gcccggcaaa aacaaacatc aagatgcgga gcgggctcat tttatcagcc 3514561 aggaatccgc ccgcaggcct gagcagcgta gaaaccgcaa taaagccagc cgtccgcaag 3514621 ccggcatctg caggattcag cccaaaatgc tccaccagaa agttcggcag atagatagtg 3514681 aaggcgacaa aggcaccgaa cgtaataaaa taaaacaggc tcagaaacca tagcacatga 3514741 tttcggtaaa cagctttgat ttgagtctta acagaaactt tgaccttctt ctcatgcctg 3514801 tcgccaaaca atacgtgcag taaggcaaag acagccagca aaatcagata catttgcacg 3514861 gttgatttcc acccgacggc ttgagcgata accggcgctg caaatgtcgt aacggctgtc 3514921 ccgatatttc ctgcaccgta aatcccattg acgacaccgt gcttttcttt cggataatat 3514981 ttcgggaggg aggtcacccc aatggaaaac accgctcccc cgatccctaa gaaaaagccg 3515041 cctgcgatta aatcaaacag agaatccgcg atactgatcc aaaatacagg aaataaaagc 3515101 aggatgaagc tgaccataaa catgagccgc gcgccaaacc tgttcgttaa ataccctaaa 3515161 ggaatgcgga gaagcgaccc gaggatcaca ggaatcgcgg tcactaaaga aatctcaccc 3515221 ttgcttaaat gaatatctaa tgtgatttgg gaaatgagtg atgaaatcag cacccaaacc 3515281 ataaaccctg ccaccaagct taatgactgt aacgataatt gaatgtgttg acggttgatc 3515341 atttggcttg cccctttcaa tgattcaata atcagtctta tcatacaaaa actagccaaa 3515401 caggattgtg aattacatca cacgtttttc tcataaaaaa aggacaaagc ccgaagactt 3515461 tgtccttttg atcgtgatta cattttttcc ggagccgata cgccgatcag ctgaagcgca 3515521 ttgttcagcg taatttgcgt tgccttcatt aaagccaggc gcgcgcggct tttctcttca 3515581 ttttcagggt cgatgacttt ctctgcgttg tagaagctgt gcagagcaga agccagatca 3515641 taaatatagt tagtgacacg gtgcggaatt cgtttttccg ctgcttccgc cactgcctct 3515701 gggaagccgc cgatcgtttt cagcagatcg tattcttttt ctgattgaat atggctgaaa 3515761 tcaagatctg ccgccggttt aagcccctgc tcttcccctt ggcgaagcat gctgcaaata 3515821 cgggcatgcg cgtattgtgc ataatacaca gggttttcgt tagatgttga tacagcaaga 3515881 tctaagtcaa aatccatatg ggtgtctgca cttcgcattg caaagaagta acgcacggca 3515941 tccaagccga cttcttcaat caggtcacgc atcgttacgg ctttaccggt ccgtttgctc 3516001 attttcattt tctcgccgtt tttgtaaagg tgaacgagct gaatgatttc tacttcaagc 3516061 gttccttttt catagcccag cgcttcgatt gccgctttca tacgcgggat gtagccgtgg 3516121 tgatcggcgc cccaaacgtt gatcagctta tcaaagccgc ggtcaagctt gtccttatga 3516181 tacgcgatat caggaagaag gtacgtgtac gtgccgtcct tcttgatcaa tacgcggtct 3516241 ttatcatcgc cgaaagtcgt ggaacggaac caagtcgcgc cgtcttcttc atagacgtgg 3516301 cctttttcgc ggagcgcttc aagcgccttg tcgatttttc cattttggta cagtgaagtt 3516361 tctgaatacc acacatcaaa cggcacacgg aagttttcca agtccttgcg aagcttttcc 3516421 agctcgtatt tcaggccgta ttcacggaaa aacgcgaggc gttcactttc ctcttcgtta 3516481 acgaaacgat caccgtattc ctcagcgaga cgctttccga tcgcaatgat atcctcaccg 3516541 cggtagccat cctccggcat cggtttttcc aatccgagtg cttcaaagta acggacttca 3516601 acagaaagcg ccagattgtt gatttggttt cccgcatcgt taatgtagta ttcgcggctt 3516661 acatcgtaac ccgcttttga aagcacgttg cacaaggaat cgccgacagc cgccccgcgc 3516721 gcatgcccga ggtgaaggtc tcccgtcgga ttcgctgata cgaattctac ctgaactcgt 3516781 tcaccgtttc cgatgttcgt ttccccgtat gcttcccctg cttccagtac agacggaatc 3516841 agctttgtta aatattgatt gttcatatag aaattgataa aacccgggcc ggcgatatcc 3516901 agtttttcaa tcgaagcctt ccctttatca aaatgggcga caatctcttc agcgatttga 3516961 cgcggcgctt tttttgccac tcttgccaac tgcatcgcca tattcgttga gtagtcgccg 3517021 tgtgttttat ctttcggtgt ttctaaaaca acattgggaa tctggctttc ttcagccagt 3517081 cccgctttca gaacggccgc tttgatttct tctttcagca cgtccttcat ttgttccgca 3517141 atgttcatgc gtgagttcct ccctcatacg tgatcgtcat attatgtaaa tgctcctgct 3517201 cgtctccgac atgcatgtca tatgcgatgc tgatacggcc tttttcttca tcgagatcag 3517261 attgaatcga ttttgtgctt gttttcagct caagctcacc aaatgacatt ttatatttag 3517321 caattgtgga agctcccgtt acgaaacgct gattcatttt gacagcgcct gacctcatga 3517381 ccaggacttc gccttcgctt actttcacaa tcgttttgac tttgcctaag tcgtgttctt 3517441 cataataaga tagatacact ttattttgtt ttacatagta aaatccggtg gtgcggaatt 3517501 cgatgacttc ttggtttccg tcatcctcga tcacagactt cacatggagt gttatcggtg 3517561 tctcttgctt cattctgaca cgtccttttc atcattccac tttgacttga atagtataat 3517621 cattcggttt gtaaacttca actgcttcta tcttaccatc attgctcatc agatttgaag 3517681 ataaacctca taaaaagcat ttccttatat agaagagaaa atcatatcac taattacctt 3517741 taggaaatgt tacatttttc cgaaatctat catttccttt tcacattttt ttcaaaatat 3517801 atgtattgaa ttagtaattt gatagtttta agataaaagt acaacataga tctgctagaa 3517861 aaacaaaaaa agggaggatt caattatgaa aaaagctgtc attgtagaaa acaaaggttg 3517921 tgcaacatgc tcgatcggag ccgcttgtct agtggacggt cctatccctg attttgaaat 3517981 tgccggtgca acaggtctat tcggtctatg ggggtaagga tctcccaaaa gggcatagtc 3518041 attctactat gcccttttta agtaaattac aatttttaac taaaatctac ctcttggata 3518101 tacatacaca accgtttttc atttgaatca tatgtatagg ggatggtatt ttgtttatag 3518161 agcagatgtt tccatttatt aatgaaagtg taagagttca ccagcttcct gagggcggcg 3518221 tgttagaaat cgactacttg cgcgataatg tctccatttc tgactttgag tatttggatc 3518281 tcaacaaaac ggcttacgag ctctgcatgc gcatggatgg ccaaaaaaca gctgagcaga 3518341 ttttagctga gcaatgtgca gtgtatgatg aatcaccgga agaccataaa gattggtatt 3518401 acgacatgct caacatgctc cagaacaagc aggttattca gcttggaaac cgggccagcc 3518461 gccatacaat caccacgagc ggaagcaatg aatttccgat gcccctgcac gccacctttg 3518521 aactgacgca ccgctgtaat ttgaaatgcg cccactgtta tttggaaagc tcacctgaag 3518581 cgctcggcac cgtgtcgatt gagcaattca aaaaaacggc tgatatgctg tttgataacg 3518641 gtgtattgac atgcgaaatc acaggtggag aaatttttgt ccatccaaac gccaatgaga 3518701 ttcttgacta tgtgtgtaaa aagttcaaaa aagtcgctgt cttaacaaac ggaacactca 3518761 tgcgaaaaga gagcctggag cttttgaaga cttacaagca aaaaatcatc gtcggcattt 3518821 ctctagatag tgtcaattcc gaggtccatg actcctttag agggagaaaa ggctcttttg 3518881 cccaaacttg taaaacgata aaattgttga gtgaccacgg tatatttgtc agagtcgcta 3518941 tgtctgtctt cgaaaaaaac atgtgggaaa tccacgatat ggcccaaaag gttcgggatc 3519001 tcggggcgaa ggcgttttct tacaattggg ttgacgattt cggaagaggc agggatattg 3519061 tccatccaac gaaagacgcc gagcagcacc gcaagtttat ggaatacgag caacatgtga 3519121 ttgatgagtt taaagatctg attccgatta ttccctatga gagaaaacgc gcggcaaatt 3519181 gcggcgctgg ctggaagtcc attgtgatca gtccgttcgg cgaagtacgt ccttgcgccc 3519241 tctttccaaa ggaattttca ttgggaaata tttttcatga ttcctatgaa agcatcttta 3519301 actcccctct cgtccataaa ctgtggcaag cgcaagcgcc gcggttcagc gaacattgca 3519361 tgaaagacaa atgcccgttc agcggctatt gcggaggctg ttacttaaaa gggctgaact 3519421 ctaacaaata tcaccggaaa aacatttgct cttgggcgaa aaatgaacaa ttagaagacg 3519481 tggtccagct tatttaggag ggaaacgatt tgtcaccagc acaaagaaga attttactgt 3519541 atatcctttc atttatcttt gtcatcggcg cagtcgtcta ttttgtcaaa agcgattatc 3519601 tgtttacgct gattttcatt gccattgcca ttctgttcgg gatgcgcgcg cggaaggctg 3519661 actcgcgatg agcattttgg atatacacga tgtatccgtt tggtatgaac gggacaacgt 3519721 catcttagaa caagtggatt tacatttaga aaaaggcgcc gtttacgggt tacttggggt 3519781 aaacggcgcc ggaaaaacga cactgattaa tacgctgaca ggcgtgaacc gcaatttcag 3519841 cgggcgtttt acactgtgcg gaattgaagc ggaggccggc atgccgcaga aaacatcaga 3519901 tcagctgaag actcaccgtt acttcgccgc cgattatccg ctgctattta cagaaattac 3519961 ggcgaaggac tatgtgtctt tcgtccattc gctttatcaa aaggattttt cagagcagca 3520021 gtttgccagt ttggccgagg cctttcattt ttcgaaatac atcaatagga gaatttcgga 3520081 gctgtccttg gggaacaggc aaaaggttgt attgatgaca ggcttattgc tgcgcgctcc 3520141 cctgtttatt ttggatgagc cgctcgtcgg tttggatgtg gaatcgatag aggtctttta 3520201 tcagaaaatg cgtgagtact gtgaagcagg cggaaccatt ttgttttctt ctcatctgct 3520261 cgatgtcgtg caaagatttt gtgattatgc ggctattctt cacaacaaac agatccaaaa 3520321 ggtcattccg attggagagg agaccgatct gcggcgggaa tttttcgagg tgatcggcca 3520381 tgaataacat aatccctatc atgtctttgc tgttcaaaca gctttacagc cggcaaggga 3520441 aaaaggacgc catccgcatt gccgcaggcc ttgtcattct ggccgtgttt gaaatcgggc 3520501 tgatccgcca ggccggcatt gatgaatcgg tgttgcgcaa aacgtatatc atactcgcgc 3520561 ttcttttgat gaacacatat atggtgtttc tttccgtgac atcacaatgg aaggaatctt 3520621 atatgaagct gagctgcctg ctgccgattt cttcacggag cttttggctc gcccagagtg 3520681 tcgttttgtt tgtcgatacc tgtttgagaa gaactttatt cttttttatt ttaccgctgt 3520741 tcttatttgg aaacggaacg ctgtcagggg cgcaaacatt gttttggctc ggcaggtttt 3520801 cgttttttac cgtttactcc attattttcg gagttgtgct aagcaaccac ttcgtcaaaa 3520861 agaagaactt gatgtttctg ctgcatgcgg cgatattcgc ctgtgtatgt atcagcgccg 3520921 ctttgatgcc ggccgccacg attccgcttt gcgcggttca tatcctgtgg gcggtggtca 3520981 ttgactttcc tgtctttctg caggcgcctc cgcagcaggg caagatgcat tcatttatgc 3521041 ggcgatctga attttcgttt tacaaaagag aatggaaccg atttatctct tctaaagcga 3521101 tgctgttaaa ttacgcggta atggcggtat tcagcggctt cttttcgttc cagatgatga 3521161 acaccggcat cttcaatcag caagtgattt atatcgtgat ttccgcgctt ttgctcatct 3521221 gctcgccgat cgcccttttg tattcgattg aaaaaaatga ccggatgctg ctcatcacgc 3521281 ttccgatcaa gcgaaaaacg atgttttggg cgaaatatcg cttttattca ggcctattgg 3521341 caggcggatt tctccttgtc gtgatgattg tgggtttcat cagcggccgt tcgatttcag 3521401 ttctcacttt tttgcagtgc attgagttgc tgctggcggg agcgtatatc aggttaactg 3521461 cggatgaaaa aaggccctcc ttcagctggc agacggagca gcagctatgg agcggtttct 3521521 caaaatatcg gtcttatctg ttttgtcttc ccctattctt agccatatta gccggcaccg 3521581 ctgtatcctt ggcggtcatt ccgatagccg gtctggtcat agtctattac ctgcaaaaac 3521641 aggatggtgg tttctttgat acaagcaaaa gagaacggct tggaagttaa cctgctgaag 3521701 actcatcaat tttcaactat ttcaatcgcc gcgagctttc tgaaaccgat cgaaagcgcg 3521761 gcggaacctg aggaagaaac gatttatttt tacggcgccg ccgcatacct gaaggagcaa 3521821 atcattgacg cttttggtta tgctgccggc agccgtttca tgtactcagc gaatctcttt 3521881 tttgatcagc agctgaaaac ctgcgggacc cgtttgattc acccattata taacgggaat 3521941 cttcatgttg acgccctgat gaaaactttt gcagacttgt ctttcccttc ttctctttca 3522001 ttcgaagcat ttgaaaaggc caggaatgag ctgctgctga aaatcgaaaa gaaattcact 3522061 gatcccttct cctactcggc ggctcgcttg gctgaggagg tcttcggaaa cccgatgtac 3522121 ggcacaggca tgtttggccg gagagacagg ataaaggcga ttcatcctaa acggtttctc 3522181 gacgcaacgg actttatcgt tgatttagtg tcccagcaaa aacagctgaa catattggga 3522241 caagtacaag catgtgatgt tcggggacat gccccgcaaa cgtccgctgt aacgtccgga 3522301 agaatacccg taaaccggca tgtttttgaa acagagacac gcagcgctgc aggtccttcc 3522361 gtcttgacac tcggatttga ctgcggagag atgaaagatg ccagcgatta tatcaaaata 3522421 cagctaatag acggattact gggaaagtac ggccattccg ctttattcaa gcacttcaga 3522481 gagaaggatc tggcagtcta tcacgttatc acccgttacg atgtcatgaa caatttgctg 3522541 cttgtttcaa tatgtacaga tcagcttcat gagaaagaca ttcccccgcg cgttttggaa 3522601 gctgtctcag cttttcatac agatgagcgg gaactagaac aggcaaagca gtttttacgc 3522661 aatgaattgc tgctgcaatt cgattctccc gaaggtctat tggcctatat gggggtcctg 3522721 cgccgcttct cctgcacgaa agaagccttg ctggatggca tctcagcggt tacatgccgt 3522781 gatgtattgc aattcatagc gaccatcaat tatatcggag ctcatgtagt aaggggatga 3522841 agagatggaa aagaaagcct tttttcaaca gctggatgaa cgaaccgata tcagatacac 3522901 agacagcgga ctaaaaatat tcagattgaa attcccccgc gcccacctgc ggctgtgcaa 3522961 tgtaaaaatc gattttggaa gccgggatgt atgtatacgg gcagaatccg gtgatacact 3523021 gcttccgtat ggcacagcac attttttaga gcatcttctc ttctggcata acggccgcaa 3523081 tctgtacagt gatttttttg cgcatggcgc gcttttaaac gcattcacta cctacaccga 3523141 taccaatttc atgtttacct cattaccgga tcggctcaga caaacgattc ccatcctgct 3523201 tgatgcttta tggaaccact catttgacaa gaagattgtc gctcaggaaa aagctgtgat 3523261 tacaagcgaa attcaaacag cacaccttaa ccatcagctc tcatatcatt atcagctgat 3523321 cagcatgctt tctccctcct caccagctgc cgttttcccc gcaggcagaa tcgaagatat 3523381 tgaggcgctg gacatcagtg atttacaaaa agcctataag gctgcctacc aagcccatcg 3523441 gatgacgctg tttttgattg ggggctcaga aaatacagaa acgcttttgc ctcctcacct 3523501 ccagctggaa aagcgtccgg attatcatgc tgaaagaaaa atcatcccgg catgccctcc 3523561 agtcctctca caaaaaatga tgctgggtga tgaggagcgg atggaagata cctggaccgg 3523621 attacagatc ggcgcacttc ccgggcaaaa cgatctgttg tcgataaagc tttattggga 3523681 tatcgcggct cgtattctat ttcaattaga ttcaccgttt tttcaagaga ttcagcaaac 3523741 gtaccgcctg gaaatcgatc gcttgtcagc cgagacttat atatatgagg atggcggttt 3523801 cttgatcctt cacagtcaag ggacccattc ttcagcttat atcgatgtgg cttcatacta 3523861 tgtcacacag aagaaagaac aggttgccgc ctggcttcaa tacggcaagg actctttgac 3523921 agacgcgatc atttatgaca gcgattatgt gcgtaaatgc ttcgagtggg cagccgagtg 3523981 tgacaggtgc gattgctcgt ttcttgacat gtaccacatc attcaagata tggatgcgca 3524041 ggttttcttg tctctcattg atgcaatggc atcttctaac aaagcgatca ttcacgtttc 3524101 tcagaaagag gcgatcagac aatgaaacaa agcactgtct ttaccctttt attgctgctt 3524161 ataggtatgg cggcttattc cttcggctgg gttcaggccg ttgccgaagc cgccgcccaa 3524221 tatgtacaga tgatcaacaa tgatgctgtg cggctcggac tgctggcttg taccgctgcc 3524281 ctcctgatgc tgcctgcttt tctctatctt cactatgtca cccaatccgt gaaaaacatg 3524341 acagcagctt ttcagaaact cacacagtct catcaaagct gctgtgactt tcagcaacac 3524401 aacttgtgca gccgatatgc agaagacgtc aaatcgctgc gtgacagcta taaaaacgtc 3524461 cgccaaacat acgtgatggc tgccgtgttg tgccaagtca tcatattcgg ctgcatgttc 3524521 gaaatcgtta aagccgtccc tttccgcctt catacgcccc ctgccttttc aatgggactt 3524581 gcgatgctac tgatcctgta tttattgttt tgcatgcgaa cgtatttgcg gcagcttttc 3524641 cggcacggca gcctgttcag aaaagtgttt gcgggagcac tggcagcagc cgggatttgg 3524701 tggatgctca gtttctctat aagtgaactg ctgtttctga ttatcctggc tgccattcag 3524761 caaatcggat catttattta taaacgattc tcttatcaca gcaccgcttc tcttgatcta 3524821 taaaatagct acatcgcaat cgcagacgga cccgcgccaa ccggaatcac cgtcacggct 3524881 gtataatcac ttgtgcggta cacggtcaca gcattgtcgt tgggctgtgc cgcataaata 3524941 tactgtttgt ccggcgttac ggcgaggtca aaggcgccgg ggagagacac gtttgcaatg 3525001 atcctctgtc tggccgtatt aactacgtat aagttattaa tgagaaacgg ttcactatat 3525061 ggctctagaa aataagctct agtactatcg agagaaaata caatcgtcct cagcgtttca 3525121 aataaacggc tgaagtcccc tcccctgctt aatggtgaca aactaatctc cgttacacct 3525181 ttcggccaca gctcaccatt caatacgtac gcaaaatttc cagcgtaagg agttgtaatt 3525241 aaactgggaa attcaaatgt atctatgata ctttctacca actgcccagt atttacatca 3525301 tatttatcaa ccgaccaact gcttccatta gcggtataga catactgtcc attcggatca 3525361 agagcaaagt ctaaagcgcc gggtatcgga atgacatcaa tgaccgattg agaggccgtg 3525421 ttaatcacat atatagatcc ggcggccatc acgtatgcga actcatctgt tggatcaaat 3525481 tcgatttttc tcggccctcc tccaacagta atggtattta tgatggttaa tgttttatta 3525541 tcaatcactg agacaaggtt ggtatttcca tggaggacat acgtgaatgc tttatcgaaa 3525601 gtaacgccta gattagttgg cacgtcagaa aaagggattg tttttacaac agtgtttaaa 3525661 tctgcatcaa taaccgaaac cgtgctgtct ccagtattgg cagtaaacac atacgattga 3525721 gggtctggtg atggcggtaa aacaagtgtc ccggccaccg taagcggact gccgtagaaa 3525781 ggcggtacaa tgagcagatc ttccactgtt atttgactga aatcaggaca gcggccagac 3525841 tgtgctgcat aataaacaac ttgatcaatc tcttcagtat gaatcacaga aacagccccg 3525901 tctccttgtc catattgatt tcgtacaggc gacacactga caagaagcgt aatggtccct 3525961 tgtactctca cagcatatcg aacaccgata tcttctggtt ccggcccagt ctggattaag 3526021 caaggctcac tgatacagga caaattgtct gtactccatg taacagccgc tgacgcttcg 3526081 gccgtatcaa ccttgaagcc ctcagggaaa tctatcggca cttgaaacgg cgcttcccgg 3526141 ctaatttcct catcacaaaa acagaaacaa ttttcctgta aagcagaaag atcattcttt 3526201 ttcatgattt cacgtccttt tagaaatgca caacatgcag cggttaaatc gtaatggcac 3526261 ccggtgaaac cccaagagat atcacagttt cctcagaata atcatctgtg ttgtaaacaa 3526321 tgatgctctg ctctataaaa cgagttgcat acagaaaatc gccattcggg gtaaacgcat 3526381 agtctgttgc tgattgcgga acatttccta taacgcctgc tccatttgga ctgacagaat 3526441 ataaattgcc agtgaagccg tcatataaat acacctctgc tccactcgta aacattcgat 3526501 attccccttc atactccagc tcttgggtgc tgctgatggt aaacgtattt aaatcaataa 3526561 ccgtcaaata attaaaaaag aattcttgtt ctaatacata ggcataccgc tccggccaat 3526621 ttgtttctat ggttgatacg ataagctctc gttcaattgt tcctgtgact tcaccggtag 3526681 ttaggtccac tttttgcact attccaaaat tcagaacata ggcgaataac ccattgggat 3526741 cgattgcaac atcatatcct tccacaggaa tcgacctatc cacagttaac gtatcaattc 3526801 caatcacata aaccgcagta ccggtgaaaa cataagcaaa ctcatgatta gggataaatc 3526861 taatcaatcg aggcggctga tccagcaata tagttgctgt cactgttaat gtgtcataat 3526921 cgatgacaga aatcacatta ttgttgggat gtaagacaaa cacagcgctt ttatctggcg 3526981 taatttcaat acctgccgga ttgtacggaa gagcaatcgt tgtcacaaca gtatcggtgt 3527041 ttgtatcaat cacagaaact gattgatcat ttggattcgc tgtaaacgcg tagacgggtt 3527101 ccggctccgg tacaagcaca attgtccccg tcaccgataa aggactgccg taaaacggcg 3527161 gaacaacaac aaggttctca atcgtgatgt cactgatatc cgggcaatca tccgattcat 3527221 cggaataata gacgacttga tcgatttctg cattgtgaat gacggaaaca gccccgtccc 3527281 cttgtccata ttgatttcgg acaggtgaga cactgacgag tagcgtaacg gttccctgca 3527341 ggcgcactgc aaattgaaca ccgacctcat caggctcagg ccccgtttga attaagcaac 3527401 ggtcactgac acaagaaagg ctgtctgcat tccacgtcac gtttgcaaca gcttcagccg 3527461 gatcaacgac aaacccttca ggtaattcaa tcggtgcttg aaacatggct tctcggcttg 3527521 cttctccctc acaaaaacat aagcactctt cttgttctgc tcctgctttt tctttaaagg 3527581 aaagcttgtt ttttctcatt ccttcacttc cttttcagac atacactgct cacgcagata 3527641 taacagaata tggaagggta acgtgtttgc ttgtacaaat tgctgagggt aaacgcttct 3527701 ttttgaaaat atatctccaa acatgcggtg taacgaaaga aaaaattgcg gtttttttgc 3527761 gcttctcaca agaatgttga tgataaaata tgacatatat agaattatga agggagggat 3527821 ttgcaaacgt gacaggtgtc atatcttctt cttccatcgg agaaaagatt aacgaatggt 3527881 atatgtacat acgccgattc agcatacccg atgcagaata tttgcgacga gaaatcaagc 3527941 aagagctgga tcaaatggaa gaagatcaag accttcattt gtactattca ctgatggagt 3528001 ttcggcacaa cctaatgctt gagtaccttg aaccgttaga aaaaatgagg attgaggaac 3528061 agccgagact gtctgatctg ctgcttgaga ttgataaaaa acaggctcgt ttaactggtc 3528121 tgcttgagta ctattttaac ttcttcagag gcatgtacga gctggaccag cgggaatatc 3528181 tgtcggctat taaatttttc aaaaaggccg aaagcaagct gatattcgtt aaggatcgga 3528241 tagagaaagc tgagtttttc tttaagatgt ctgaatctta ttactatatg aaacaaacgt 3528301 atttttcaat ggactatgca cggcaagcat atgaaatata caaagaacat gaagcttata 3528361 atataagatt gctgcagtgt cattctttat ttgccaccaa ttttttagat ttaaaacagt 3528421 atgaggatgc catctcacat tttcaaaaag cttattctat ggcagaagct gaaaagcagc 3528481 cccaattaat ggggagaact ttgtacaata tcgggctttg taaaaacagc caaagccaat 3528541 atgaggatgc cataccttat ttcaaaagag caatagctgt ttttgaagaa tcaaatattc 3528601 ttccttcctt acctcaagcg tattttttaa ttacacagat ccattataaa ttaggaaaaa 3528661 tagataaagc tcatgaatat catagtaagg gaatggctta ttcacaaaag gccggagatg 3528721 taatatattt atcagagttt gaatttttga aatctttata cttatcaggc ccggatgaag 3528781 aagcaattca aggatttttt gattttctcg aaagtaaaat gttgtatgct gatcttgaag 3528841 atttcgctat tgatgtggca aaatattatc atgaacgtaa aaattttcaa aaagcttctg 3528901 cttatttttt gaaggtggaa caagtaaggc aacttattca aggaggagtg agtttgtatg 3528961 aaattgaagt ctaaactatt actctcttgt ctggctctaa gcactgtgtt cgtggcaaca 3529021 actattgcaa atgcacctac acaccaaatt gaagttgcac aacgaggaat gatttaaccg 3529081 ccgtccatcg gcggtttttt cgtcccctct ttaccaaagt ctcccaatcc atgctatgat 3529141 cttttcaata atcttgaaga gagtggaaat gcagcatgtc tctaaaaagt gtgagaaccc 3529201 actttactca atggaatcga gaaaatgatg tgacggagtt cgaaacgtcg agtgcgacag 3529261 ttgaacaggc agctgagaca atcggcgtaa gcctgtctag aatcgccaag tccctgtcct 3529321 tcagagggga aggagatcag gtgattctga ttgtggcagc cggcgatgcc aagatcgaca 3529381 acaaaaagtc caggcaaaca tttggcttta aagcaagaat gctctctcct aatgaggtgc 3529441 tggagcagac aggccatgaa attggaggag tttgcccatt tggattggct catgatcctg 3529501 aggtttatct tgatgtatcg ctgaaacggt ttcagactgt tttccccgca tgcggcagca 3529561 gaaactccgc tattgaatta acaccgaaag aattatccga attttctttc tcaaaagtgt 3529621 ggattgatgt ttgtaaagac tgggaataaa aaaacatcca gacatcgtct ggatgtttac 3529681 ttatttcaca aacccaagca gcatttcacg gatgattttg ctggctgtgt ttgccgtttg 3529741 ctctgagtgg tcgtataccg gcgcgacttc cactaaatca gcgcccttta cgtttacctc 3529801 tgaacgcgca atttcatgga ccgatgcaag cagttcttta gacgtgatgc cgccggcgtc 3529861 aaccgttcct gtacccggtg cgtgtgcagg gtctaatacg tcaatgtcaa ttgtgacata 3529921 aaccggacgg cccgccagct tcggaagcac ctctttcagc ggttcaagca cttcaaattt 3529981 tgagatgtgc atgccgtttt ccttcgccca ttcaaactct tctttcatgc cggaacggat 3530041 tccgaatgaa tacacattgt gcggtccgat caattctgcc gccttacgga tcggcgtgga 3530101 gtgagaaagc ggttctccct cataatcaac acgaagatct gtatgtgcgt caaaatggat 3530161 aatcgcaagg tctgggtatt tcttgtacat cgctttaatg acaggccatg acacgaggtg 3530221 ctccccgccc atacccattg ggaacttccc tttttctaaa atgctgtcca cgtactcttc 3530281 aatcatatcc aggcttcgct gcggatttcc gaacggcagc ggaatgtcgc cagcgtcaaa 3530341 gaagttcaag tcagccagat cgcggtctaa atatgggctg tattcctcaa ggccgattga 3530401 cacctcacgg attctgcttg gaccaaagcg tgagcccggg cgatagctga ctgtccagtc 3530461 catcggcatg ccgtaaagaa tggcgtccgc ctcttcccac tcgggacggc tcgcgataaa 3530521 tacttttcct gaataagctt catcaaatct catctataat accctcgctt tcctgtaaaa 3530581 aagcgcaaga ttcgctcctg cgccatacct tcattattta atcaggtcac tcacaaattt 3530641 cggcagaaca aacgccgctt tatgaatatc ttttgtgtaa tatttcgtct caatatcgaa 3530701 gaaacggctg tcttccactg caagcggatc atattttttc gagccaattg taaatgtcca 3530761 caaaccgctt ggatatgtcg gaatgttcgc cgtatacagc ttcgtaatcg ggaagatttc 3530821 cttcacgtcg cgctgtacat ttgtgattaa ttccggtgta aaccatgggt tgtccgtctg 3530881 cgcaacgaaa ataccgtctt ctttcagcgc ttttgcgatt cctgcgtaga atccttttgt 3530941 aaacaggttt acagccggtc cgactggttc agtcgaatct accatgatga cgtcatattg 3531001 attttcagat tttgcaatgt gcataaatcc gtcatctacc tgcacgtcaa cgcgcggatc 3531061 atccagtttg cctgcgatag aaggaaggaa ctttttagag tattcgataa ccttgccgtc 3531121 aatatctaca agtgtcgctt ttttcacgct tgggtgcttc aggatttctc tgataacgcc 3531181 gccgtcaccg ccgccgacta cgagaacgtg ctccggattt gggtgcgtga ataatgggac 3531241 atgcgccacc atttcgtgat aaacgaattc gtctttttca gatgtcatca ccatgccgtc 3531301 caaaaaaagc atgttgccga actcttctgt ttccaccatt tctaaatgct gaaactccgt 3531361 ttgttctgta tgtaacgtct tgttaacctt catcgtaatg ccaaagtttt tcgtctgctt 3531421 ctctgtgtac caaagttcgc tcaattgtca tctccctttc gaggctgtat tcatttattg 3531481 taagcgtctt atcagctttt attctcggtt gaaatctcat tttcacctaa ggaaaaagta 3531541 tagaggatgg cggggaaaaa gtaaagatgc gtcctgttct gcgatgttta aaaacgatct 3531601 ttttttctca taatagtaga aacataaaaa aagggggaac ccgttgtgga tgcaatgaca 3531661 aataaacggc tgagactgac gctgaaaacc gttcgcgcct ttatcttttt aggggctttt 3531721 gcggccttgg cggcagctgc tgtgtttatg actgtcattt tgatagccaa ataccagggc 3531781 gctccctcgg tgcaagtgcc gcaatccacg attttgtacg cgagtgacgg ctcaaagctc 3531841 ggggaaacga actacggcga aaagcgctat tgggtcccct taaaggacat gaatccgacg 3531901 atcgtaaaag cgacagtggc gattgaagac cagaatttct acgatcatca cggctttgat 3531961 tataaacgca tggccggcgc ggcgcttgct gacctgaaag catttgccaa ggttcagggt 3532021 gcaagcacca tcacccagca atatgcgaga aacttatacc ttgaacacga caaaacgtgg 3532081 aaacggaaat ggaatgaggc gttctacacg atccgtctgg aacaaaacta ttctaaggac 3532141 gagatattag aaggctattt aaatacgatt tactacggcc acggcgccta cggcattgaa 3532201 gcagcttccc gcctgtattt cggcaagcat gccaaaaacc tgacggatgc ggaggcggcg 3532261 cttttggcag gaatcccgaa aggcccttcc ggctattcac cgtatgtcaa tgagacgaag 3532321 gccaaggaac gccagaaaac gattgtgcgg atgatggaaa agcagcagat gatcagccaa 3532381 aagaaagcgg atgaattgat caaggaacct ctttcctatc agcctttgaa taaacaagtt 3532441 tccaagagaa aggctcctta tttctacgac aatgcgatga gagagctgga aaaaaagctc 3532501 ggcatgacac gggagcaaat tgaaacgagc gggttaaacg tctatacaac ggtagataaa 3532561 cggatgcagc gcatcgccga ggagaccatt accgaaacgg ttaacgcggg ctctgacatt 3532621 caagtcgggt tttcagccat tgatccccgc accggaaacg ttctcgccct tgtcggcggc 3532681 agggattatc aaaaaagccc gtttgaccgg acgacacagg cgaagcgcca gcctgcttcg 3532741 acgatcaagc cgttgctgta ctataaagcg attcagagcg gatttacgcc agtcactttg 3532801 atgaaaagcg aagaaaccga gtttcaaatt gatgcaaagg gagaaaccta ttctccaagc 3532861 aactataacg gatactatgc caacaagccg attacgcttc tgcaggcgct ggcgctttcc 3532921 gacaatattt acgctgtgaa aacgcatctt tttctcggca cgaacaaact tgtaaagacg 3532981 gcaaaggaat tcggcattac cgcccatctt caagcactgc cgtccctggc actcggcacc 3533041 gaacccgtac gtccgattga gatggtcaac gcctatgcca tgctcgcaaa tggcggaaag 3533101 aaaatcgaac cgacttttat ttcaagagta acggacgcag ccggccacgt gctgtacgaa 3533161 aacccgaatc agcataaaca ggtgcttgat gaaaaagccg cttttgtcac agcgagtatg 3533221 atgacaggca tgtttgatat cgatttaaat ggatatacgt cggttacggg gcgaacgata 3533281 gccaaccgcc tgacaagaac gtatgccgga aaatcaggaa ccaccagcgc agacagctgg 3533341 atgatcggct tcaatccgaa gctggccgcc ggtgtttgga ccggctatga caaaaacagc 3533401 accatcgact cggtcgaaga aaaaagctat gctaaaacca tttgggcgga cttcatggag 3533461 gacgcgctca aaggcgaacc ggaaaccgcg ttcaagccgc caaaaggcgt aaccggtgtg 3533521 tacattgatc cggaaacagg ctactcatca ggtcccggct gcgccgctaa gcattacaca 3533581 tattttgtga aagggacaga acccgcaaac gtgtgctacg gggcagaacc cgcaaaacaa 3533641 acaaaagacc ggcttccatc caaagaaaag cccgcttccg agaaaaagtg gtgggacaaa 3533701 tggctggggc gacatcattg aaaataaccc ggctcctcgg aggccgggtt attcgtatgg 3533761 ttccttcata atcgatggaa gaatgttaga caatcgagct gaacaatcag ttttgggata 3533821 aagtggtgaa tttctcattt cttcggcgct ggctttcatc tcccagtcgc cgactcatat 3533881 ccccctaaaa atgaaaaacc ccgagtcttg tttcggctcg ggattttcca tgtcctattt 3533941 ctgtatcacc agtttactca atgtttacga aaaatatctc aaatacttta aaagttcaca 3534001 aaaaattcat aaattaattg ttttctggaa gcaggctcgt ttttaactca tctgaggaac 3534061 ggtcccatag gccctgatca tgctttttca gaaattcgcc tagtacacgc ttcgagctgt 3534121 cgtccatttt atcaacgatg attttccgtt tcatggattt atccatcaga ttcacatgct 3534181 caggcagtga cttgtagcct cttctgatgc ttctgtcgac cgtcatttca caggctgtca 3534241 caccagcgta ataaggcccc tcttcttttc tgtcaatcgt tacccacaca agccagtatg 3534301 gttttccgtt cggcacttct tctttattcg ggagaaattt aattcctttt tcaacggtgc 3534361 tgcgggcatg catagcgccg atgtctacga acgcttcttt ttcctctaca tcaacgaata 3534421 cgggagaaat gttatcaagg ctgagtgccc ctacgccaaa accgccgtgt ccgtctgtcg 3534481 gatcactttt gataatatta aacccgattg attttttctt tttttcttcc atgaagttct 3534541 acctcctaca aaagcggttg aaatatcgct gaaaacagct ttaaaatcga atctcttcct 3534601 gcattgagca tcggccacag cacgtaagat cctagcggtg tcacaaacag caccaaaaat 3534661 acgataaagc cgtagctctc cgcctgcgtc attttggcac gcacgcccgg cggaacgaga 3534721 tcttctataa ttcgatagcc atcgagcgga ggaagcggca gcagattaaa taaaaacaag 3534781 acaagattca gctgtatcca aatagaaaaa aactgatcca gccccgtgct gaacgccgca 3534841 agcatttcca ttccgtacgc atgcatcaac actaacaaaa agaaaccaat aaacgcaaga 3534901 atcaggttac tgacgggccc ggctatagat acgagcacac cagcaagccg gggtttctta 3534961 aagaaacggc gattcacggg aatggggcgc gcccacccga atccggccac cagaatcaaa 3535021 atggttccga acggatcaag gtgtttaatg ggattcagcg tcagtcttcc ttgttttttc 3535081 gccgtatcgt caccgaattt gtatgcgaca taagcgtggg caagctcgtg catcgtaaac 3535141 gacacaatta gcgtgatgac gaggtatggc attaaagata acggataata taaaaaacgg 3535201 tccaagtgag atatccctct ttctcaaaat gcaagaattt actttattca gtatactata 3535261 agaagcctct ttttctaaag agaggaaacg agataaagga ggattcagca cccatgccat 3535321 acgtaactgt caaaatgctc gaaggccgta cagacgagca aaaacgcaat cttgtcgaga 3535381 aagtaacaga agccgtaaag gaaacaaccg gtgcttctga agaaaaaatt gttgtcttta 3535441 tagaagaaat gagaaaagac cattatgccg tcgcaggcaa acgcctgagc gatatggaat 3535501 aatctctata aagccggcgc ttcgcgcacc ggcttttatt atccctattg agccagcttc 3535561 gcaataatcg ccaagaacgt ctttttctct tcggctgtta aacgttcaaa catgccatca 3535621 atcagctgct ggcggttttc gatcatttgt tcagccgctc cccggcccga ttcagaaaga 3535681 gtaatccata cagtgcggcg gtcattgtta tttctggatc tctcaataaa cccttcctgc 3535741 tctaaatgat tcagagctgt ggtcgtggca gagggagaca gtgtgacctc cttcaaaata 3535801 tcctttatgg tgcagctccc atgtctgtat atgatccgca gaataaaccc tcttacatta 3535861 ttcacgtgtt tcggaacggt ggcttcatct aattgcttcg tgcttttcaa atactttgta 3535921 agtgcgtgat ccagcaaatt tgcttccagt ttgtcatggt ccatgtcaat ttccccattt 3535981 cgagatgcat tcataacata cgaacgatat gatttactta ttattttact gattccgaat 3536041 agggaaagtc aaaaaagcaa aatgtgaatt cacagctttt atcctacatg cctcgatttt 3536101 ccacctgttt cacaagttta tctttaaaag tttggaaagg aacgtgttca ttctgctgat 3536161 gtccgaatcg gcggacgttt accgcattct cctgctcctc atgatctcca agcaccagca 3536221 cgtacggaat tttttgcacc tgcgattctc tgattttata gccgagcttc tcattgcgct 3536281 catcaatgcc ggctcttatc cccgcctgct tcagctccgc ctgcactttt ctgcaatagt 3536341 ctaagtgaac gtgcgaaacc ggtatgattt gaacctggat cggtgcgagc cagactggaa 3536401 aagccccacc gtaatgctcg atcaaaatgc cgaagaaacg gtcgattgag ccgaaaaccg 3536461 ctctgtggat gacaacggga cgaaccttct cattgagttc gttgatatat gttaaatcaa 3536521 atttttccgg catttgaaaa tcaagctgaa ttgtcgcgca ttggtggctc cgtttcaggg 3536581 catcttttat atggaaatca attttcggcc cgtaaaacgc cccatcgcct tcattgatct 3536641 cataagagag gccaagctcc tcaaggacgc gtgctaaggc acgttccgac gcttcccaaa 3536701 ggctgtcatc gcctaatgaa tcctccgggc gagtcgaaag ctcaacagaa tactcgaaac 3536761 caaatgtccg atatacctca tcaatcagcc gaatcgcttc tttgatctca ctctcaatct 3536821 gatcctcccg aacgaaaata tgggcgtcat cctgacagaa cgtccgaacg cgaagcattc 3536881 cgtttaaagc gccgctgtat tcatggcggt gcacctgtcc gaattccgcc atgcgaatcg 3536941 gcagatcccg ataagaatac aggctgtttt taaagatgag catgtggccg gggcaattca 3537001 tcggcttcat tgcgaatctt gtatcatcca cttctgaaaa gtacatattg tcgcgataat 3537061 ggtcccaatg gcctgactgc tcccataacc gctgattcat cataaacggc gtacgcacct 3537121 catcgtagcc ggcatttgtt tgcagctcac gcgagaagcg ctccagctca ttgcggacaa 3537181 tctgcccttt cggcaaataa aacggcatcc ccggcgcttc ttcagaaaac ataaacagcc 3537241 ctaactgttt gccgagcttg cgatggtctc gttttgccgc ttcttctagc atatgcaggt 3537301 gcgcatccaa atcttttttc ttttgaaacg caaccccgta cacccgctgc aggacttcat 3537361 ttttgctgtc tccgcgccaa taagcgcctg atactcttgt cagtttgaac gccttgatca 3537421 tccctgtaga aggaagatgc ggccctcggc acaggtcaac gaattcccct tgctggtaca 3537481 gtgtgatatc ctccccgcgc ggaatatcct ttaaaatctc aagcttgagc cgctcgtctt 3537541 tttgtgcaaa cagctcttca gcttcttcgt aagaaacctc tatacgtttg atttcaaggt 3537601 tctcatttat tatgtttttc atttcttttt cgatggcctc taagtctcct gatgccaagc 3537661 ttttccccag cttcatgtca tagtagaagc cgtctaaaat cacaggccct acccccaatg 3537721 acacttcgcc gtacagccgt tttactgctt gggccagcac gtgcgctgtt gtgtggcgaa 3537781 gcacctgcaa gccttcttgt gaatcgagtg tgacaatcga aagctcagca tcctcctcca 3537841 gcttgaaact gagatcaaca agcttgccgt tgacctgacc tgcggccgcc ttcttttgca 3537901 gactggaact gatcgaacca gccgcttctt tgattgtgat gcctttcgga tattcctgga 3537961 tctgtccgtc cggaagctga atgtgtacat gtttgctcat tttagaacac tccttattca 3538021 ttgttgtata taaaaaaaca cacccgtccc gcagataggg acgagtgtgt gattaacccg 3538081 tggttccacc caagttcccg acaaatacta tgttgtcggc tcggtgctgt aacgcagcat 3538141 agacggcatt ggttacttca gttccccaat gctgctccaa ggcggtaaat gatattccta 3538201 agctgggaag ctctcacctt tccttccctc tctgaaaacc gtaactatca ttcatgtcct 3538261 tttcatcgca tgtattcaat tcataaaaaa acacacccgt cccacagata gggacgagtg 3538321 tgtgattaac ccgtggttcc acccaagttc ccgacaaata ctatgttgtc ggctcggtgc 3538381 tgtaacgcag catagacggc attggttact tcagttcccc aatgctgctc caaggcggta 3538441 aatgatattc ctaagctggg aagctctcac ctttccttcc ctctctgaaa accgtaacta 3538501 tcattcatgt ccttttcttc gcatgtattc aattcaaata aaaaaacaca cccatccctc 3538561 taaaagggac gaatgtgttg atcatccgtg gttccaccca aattcccgat caattacaca 3538621 tgatgatcgg cttaaagatg ctgtaacgca gcatgacggt atcagatact tgttttccct 3538681 gatacggctc aaaggcggta agctgctttc cctgcgttag gaagatctca gctgtccttc 3538741 cctctctgga aaccgtaaaa agcatctcgt gtccttatca gtgcctgttg tttcaataat 3538801 tttttatatc ttactatata ttcccacaaa gcgcaatcag tgatttacat tttttctgac 3538861 gcggcagtcc cgttatgggc agccagaaac agccatacaa gcaatgcagc gaggctgtat 3538921 gccgctccca tcatcaaaaa cgcaaacccg gcaccagcat accaagtggc ggacagatga 3538981 atgatcaccc cggttatcgc tacgccgacc aaggctccga tttgccggtt tgcatttaac 3539041 gccgcaccgg cgatattcgt atgtctttgc ccggcagcct gcatgatcac agttgtcatg 3539101 gcaggaactg taataccggt acagaggttc ataacagaca tcaacaccgc cagctgccaa 3539161 taaggaaaat ccggagaaat cagcacaaac aacagcaatg caatgataca gctgaccgcc 3539221 attgatacaa acataagctg accggcttca aaccgattcg ccagacgggc aaacagcaga 3539281 ttgccgatca cgaagaccgc catcatcggc agcagctcca ctccagccat aaaggaactt 3539341 gcccctcctg cttcctgcaa aaaaaggctg agcataaaca tgccgccaaa aagggcgaaa 3539401 ttcagcaaaa acccgataaa ttgggcagct gagaagcggc cgtttttgta taaggacgcc 3539461 ggcaggatgg gtgtttttgc agaaatttcc cgcagcaaaa acagcacaaa tgccaaaacc 3539521 gctgcagtaa atgctacaag aatcactggc gagcgccagc ccgctgaagg cccctgtatc 3539581 aaagcatagg aaagaaaccc gagagccatc atgccaagca gatgcccgat gatgttcacg 3539641 cggctgcttt tcccaggaac gcggctgagg attcggtaag ctgaaatgag cgcagcagcc 3539701 cctattggca cattgatcag aaaaatactc tgccagcccg ccaactgtac cagcacgccc 3539761 ccgataaaag gcccaagggc tgaagcggcg gaaacaagcg cggcccacag tccaaacatt 3539821 ctcgcccgcg cccgctcatc aaggtaagag gcagccaaaa ggctgagtga gcttggcata 3539881 aacaaagctg ccccaattcc ctgtatgaga cgtccggcaa tcagcatctg cccatttata 3539941 gatgcagcgc atagacagga ggccataaca aaaacggcta gacccaagat atagatcgtc 3540001 ttcgagccga aacggtcagc caaggctccg cccgccagca gaagcgacgc aaaagtaaga 3540061 atgtacccgt ccacaaccca cgttacacct gaaagtgaca ttgaaagagt gtttttcata 3540121 tcagccatcg ccacattcac aacggtcaca tcaagagttg ccatgaggaa accaagtgcg 3540181 agcacgatca gcacggatat gcctgttgat gatgttgatt cttgtataga cccgctattt 3540241 ttcattacaa ttgccctttc acttgcttga ttacccaatc atctattttt tcaagatcat 3540301 acaattcccc gactctgtcc ataacatgct gcaaggattc ttctctcata agattggacc 3540361 atttatcctc gatttccgcc atgactgtct ccagcacaca gtgactttca ccctcaaata 3540421 cagattgcag caagcctttc ccctgataca tcgaacctct gccttcgacc gcttgataaa 3540481 catcataaag cgtaatgtca gccaaaggct tcgtcagggt aaaaccgccc ttcgtccctg 3540541 gtaaggattc tgccaaaccg gcttgaacca atgttctcat cagcttcttc aagtaagacg 3540601 gagacacgcg caatcgctgg cttatagcct ctgacgtcaa agaagcctgt accggcagcc 3540661 gtgacagtaa cagcagcaca gaaaccgcct gctccattcc tgatttcatt ttcatcctat 3540721 tcactcctga ttcattatgg ataactatta tccataatga atctcttagc agcttttgtc 3540781 aataaaaaaa gcaaaagaaa cggatcattt cttttgcttg gtatggttaa caaatctgct 3540841 tcagttcctc tatgtattga agcgcttcgt catattcttc atttgtatat ttttgcttgc 3540901 ttttgatggt aaagactttt tctttctttt cctcatcctc aagcccgtca aagtaaagga 3540961 tcgtggaaac cagctctaaa aaccgtgatg aacggctgtt tacactgtcg atatagcctt 3541021 tcatatccgg catgtccaga tcagcatggt ctaaaaatgc ggagcctgtc tcagtcagcg 3541081 aataccggta ttgaaagtag ccgccctttt tttccttcac ctcatgcaga aatccaaggt 3541141 tgcacagctc ttcaatctgg agcgtcagtt cctctgaata tggtccgtaa aagtgaaaat 3541201 catatttctc atagaaagga aactgcattt tcttggcgat ataaatcatt ttctgcagct 3541261 tctttcgccc gatgatttct ccagaatccg agaacacctt catcagtttt gcatgttctt 3541321 tcaacaaatt cccgacatct cctttttcct tctttccaat ttctatgtca gtcccagcag 3541381 ctgccggatt ttcattttcg cttccggatg tttagtgccg tcacaaatca agtcctttgg 3541441 atagtacagc ttgtggtccg tccgccgttt acctgagatg gattccacaa tagccgactg 3541501 tctggacagc tctttaattt ggccgttttg cgtcaagaga tggatcggca gacgctcctc 3541561 ttcctctcct ggtcggtaaa aatcgtatgg cagatctgat gaagaatcaa cgaccaaata 3541621 atagctcgga tcgatccccg cctctttgaa caatgaagtc agctcaaaat aagccgacat 3541681 ttcttcattc ggattgaatt caacgtattg gaaaagctgg cggttaatga atctgcggca 3541741 caagtcggat aaaatcgcgt cttcttcatc ctcccaggcc tggaagtaat acaaaataat 3541801 agattcatcc agctttacat aatcctccag tgtcaatttt ccttcaaaaa tagaatagaa 3541861 atgaaccgga gcgtgagtga agacatagcc ttcatcgtgc agctgcttcg ccctgtgaag 3541921 aatcttcgtt aaaatgacct ctgcacttct agtcacagga tggaagtaga cctgccagta 3541981 catttggtaa cggctcatga tatagtcttc gacagcgtgc attccgcttt ctttaatgac 3542041 gatctgatcc tcgcgcggcc gcatcacccg aagaatccgc tccatatcaa aatggccgta 3542101 gctgacgccc gtataatatg cgtcgcgctg gaggtaatcc atgcggtctg cgtcaatctg 3542161 actcgaaatc aggctgacca cttgcttgtt tttatatgtt ttggcaatga cttcagcaac 3542221 atcctgaggg aaacccgggc tcacctttct gagcacctga ttaacctccg tgtctcccaa 3542281 aatgatacct cttgtaaaat cctcgtggtc aaggtgaaag accttttcaa atgaatgcga 3542341 gaacggcccg tgcccgaggt catgaagcag cgccgcggcc aaacagagtt cgcgctcact 3542401 gtcatcccat tcagggcggc ctttaaagac gtcatcaacc attcttctga caatttcata 3542461 gacaccgaga gaatggttga accggctgtg ctcagcccca tggaacgtca aataggtcgt 3542521 tccgagctgc ttaattctgc ggagacgctg aaattcacgg gttccgatca aatcccatat 3542581 cagcttgtcc cgaacatgaa catagcggtg caccggatct ttaaacactt tttcttctga 3542641 taattttcca tttggatacg ccatcgtcat tccctctttt ttttagccgt gtttctatta 3542701 tatcgactct attctttgaa aacatccttg aatttgcccg gcgatttgtt ccatcttcat 3542761 gaaaaacaca tcttgtgaag caaaaaagcc tgacctgagg gccgaggcta agaaaaaata 3542821 tgtttttact tttttatttt cttttttact ttgtcaatca gctcatcctc tgtcggagct 3542881 gacagcgggc gattgttcac aaaagcaaat gattttttcc gtccgggccc gcaataagat 3542941 tggcatccta cctcaacctt tgcgtccggg tccacttctt tcaaacgcgg cagcaatgtt 3543001 ttgatattag tggcttggca atcatcacac actcgaaatt cattagccat gacgtacgct 3543061 tcccttcatt tctatgttca tctatgtgaa taacctaaaa tcacgtttca aaaaaaatca 3543121 catcacactt cattttacaa ggattcgact gttcctgcaa gccgctccat ccttcgtatc 3543181 tcctattctt tcagccaatt tgtataaata ttttccaacc tggacattct aataccatga 3543241 aaagaaaaat gggagttgag ataaatgaca aaacagcgac aagacgcttg gtcagaggaa 3543301 aacgatctgc ttttagccga aacagtgctt cggcatgtga gggagggcag cactcagctg 3543361 aacgcctttg aagaagtcgg cgataaatta aaccggacat ccgcagcctg cggattcaga 3543421 tggaacgcag tggtccgcca tcaatatgaa aaagcgcttc agcttgcgaa gaaacaacga 3543481 aaacagcgga tgagagcgct cggaaacggg cagcccgcga aaaaaagatt attatatcag 3543541 cctcctgccg ttgatcctga aatcattcaa gaaaccgctg cagaagagcc ggttaaaacg 3543601 gaaacaccat ctgtcgaaaa tgagcaacct ttaatgtctg gcgaacacat gccttttgtt 3543661 gatgaaagct ttaaggaaga gttagctagt ctatcacact tattgtctcc tcaaacgcct 3543721 gcagctgcgc ctgagatgac gatgaatgat gtgatccgct tcctgcagaa ttacgaaggc 3543781 aatcacgagc aatcatcagc attaaaaatg gaaaacgagc gtttaaagaa agaaaatcag 3543841 gaattgcaaa acaaaacaga gcagctagag gcagaagttc aaaagcttga aaaagaccaa 3543901 aaaacgatcc aagaagatta tgaaaccttg gtgaaaatta tgaacagagc cagaaagcta 3543961 gttttatttg aagaagatga acatgcctct ccgtccttca aaatggaccg gaacggcaat 3544021 ttagaaaaat tagcggaatg acatagaaaa atcccaaaac gggcagctgt tttgggattt 3544081 tcgccatgtg caaaatcccc ttttctattg agaaaagaga atttcctcat tttgcagccg 3544141 gatcagctat tcttgtaaaa tgaggccaag cttatgtgaa tctattaaga catgtgagct 3544201 gcctcggccg ttttttgttt ccgaggcgca gcagaaatga ccaaaagccc cagcatcata 3544261 agcgcaatgc ccagccacga ggaaggcgaa agcatttccc ctatgaaaaa cacgccaagc 3544321 aatgaagccg tcagcggttc agctaaagac agcgtgaccg ccgccgaggc cggaaccccg 3544381 gtaagccctt tcgcaaacaa aaagtatgcg gcacatgttg caattaaccc gatgtaaagg 3544441 cttgttccca gtcctctagg ggtcaatatc cacgagatat ctaactgcca taatagcggc 3544501 gtcagcaaga tggcgctgat catgaataca acggcggagg tcgctcgcgg aggctgggtt 3544561 ttcatcatcg ctttactgat gagcgtatag cctgcaaaag aagcacccgc tccaagcgcc 3544621 ataagaacac cagccacatc aatccgaaca ttggaactgt cggaaaacag aagccagcaa 3544681 cccgctaaag ccagcacagt cgcaatccac caggagtttc gcgggcgttt cttcaataca 3544741 gcccattcga gggtcccggc aatgataggc gcactgccga tggcaatcac agttcccact 3544801 gcaattcccg tttctttaac cgctgtgaaa aacagcggct ggtaacacgc catacaaaca 3544861 gcggctaaaa atacgagcgg ccatgcccaa tttttcacgt gaagctcccg gctgatccaa 3544921 accgcaagca gcatggcgct tcctcctatt aataacctga acgctccaaa tgccagcggt 3544981 gtggcgcttt ctggagccaa tgcctgaacg gttcccgtgg tcccccagaa aaaagccgca 3545041 atcaatacaa aaaggctgta aatattcccc ttcatctgcc tctccccttt aatatggatg 3545101 ctgatgtcat tttatcgttt ttctttttgt cgtggttatc tgtatgtaag aaggacttat 3545161 ctgaaaataa gattattgag gtaaaatgcc gcttgagata aaaaatgcat gccggcatat 3545221 acagccggca tgcgaagaac gttcacccaa atacctttgc attccgctca gccatccgga 3545281 cgaggttttt ctcaaattcc atttcctcat caatggacag tccagctgaa taaagatggg 3545341 tgcttaacgc ttttaattcc gtcaataaag cgaacattaa gtcttgtacg gagatgtctt 3545401 tttgaagaag ctcacttaag gacgccatcg tttccggacg tatttccgga tagacgcctt 3545461 ttttatcgtt ttgtttgtct ttcagcgccg cttgatagaa tcgtctgatc aagtcggccc 3545521 tttcactgcc gcttttatct gcacagagat aaatttgaac agcgactccg ccgcgaacgc 3545581 gtctctgaga gatgccggcg aactttttgc catttatact gaggtcatag ctgccgggac 3545641 aataagaccc ttcaatttca taggcttcga tctttgcgtt gtacggtctc agcattcgtc 3545701 tcatcagctc gaccatcgct tcatatcctt tgtctatatc gatgcctttc ttttcgtcct 3545761 cgaatatgag agagatattt aaaacaccgt catccaatac gacggcaaga ccgccggaat 3545821 tgcgtacgat cacacggtat ccttcgctct ccagcaagga gataccatcc tgcaaaaacg 3545881 ggaggcgtgt atcctgtatt ccaaggacaa ttgtatcgtg gtgcacccat gagcgcgctg 3545941 tcgccggcga cacgcctttt ccgacggaca tgcatagcgt atcatccatt gcgaaggatt 3546001 gcttcgcatc aaataaaggg ccgagactgg attggtcaat gactctccat ttcggctgca 3546061 tcagtaaatc aatcggttgg tttgccatct atgtaaaacc ctttcatgtt aggcttattg 3546121 aacgaaaact attatatcat ttcagcagct gtgattgata attgcttttc agcatcgtaa 3546181 taaaaatttc tttatttttt gtattctcca tgagaggaga atgaatgtaa gacagcttgc 3546241 gctttaacga gaaattatta atatgcagaa ttgaaatttc gcggtggatc aaatccttac 3546301 gcagcacgct tctggataga accgaaagtc ccatgccgtt aatcaccgct tcctttacac 3546361 cttgattgct gctgatggta aacattgatt tcggccgaag tccatttgaa ctgagtacat 3546421 gatcgagata ttctctcgtc ccggagcctt tctctcttgt cacccacgct tcgttctgca 3546481 aatcgctgat cgaaatctct ttccgcccgg cgagcggatg ctgatttgga gcggcaatgc 3546541 acatttcatc ctccatgaac ggttcaattt ccagctcatt ctcgtttgta tgtccttcaa 3546601 tcagcccgat atcagcctga agcatccgca cacgctcgct gacctcctct gtattgccaa 3546661 tcatgacatc tagattcagc tctggataca gcttttgcag ctgggccaat agcggcggaa 3546721 gaatatactc accgattgta aagcttgcag ctattttcaa ttcacccttc acatagtgat 3546781 gatgcgcata gatttcagcc ttggcttgtt cgtagagaaa caccatttgc tttgctcttt 3546841 gatataaaat gtctcctgtc ggcgttgtcg taaagtgttt tggcgacctg ttcagaagag 3546901 ccgtttgaaa ttctttctca agatttttga tatgcagact gacgctgggc tgggagatca 3546961 tcagcttttc cgccgctttt gtgaagtttt tttcttctac caccgctata aacgttttca 3547021 gcacgtcgta atacaaaaac cccacccctg tcattaatga aatatatggt tatgattagt 3547081 tttctttatt gtactcatat catccgtctt ggtaaagaag ggctatacag aagcgcaaaa 3547141 aaggcagccc tcggtcgaga gctgccattg tcttcaattt tattacagtg cttgcgccgc 3547201 tgtaattaat gcgagattgt aaacatcttc agcgttacat cctcttgaaa ggtcgtttac 3547261 aggcatattt aaaccttgca ggattggtcc taccgcttca aagttgccca aacgctgagc 3547321 gattttatag ccgatgtttc ctgcttcaag acttgggaat acgaatacgt tagcgtcccc 3547381 tttgatctcg gaatccggcg cttttttctc agctacagat ggaacaaatg cagcatcaaa 3547441 ttggaattcg ccgtcaagtg tcagttcagg cgctttttct ttcgcgattt tcactgcatc 3547501 cgctactttt tctgtttcat cagattttgc tgagcctttt gtagagaagc tgagcattgc 3547561 cacgcgaggc tcaatgtcga acatttttgc cgtattggca ctttcgatcg caatctcggc 3547621 aagatcttgg ctgtcaggtg caatgttgat cgcgcaatct gcgaatacgt attgctcttc 3547681 tccgcgagcc atgatgaaca cgcctgaagt ctttttcacg ccttcttttg ttttgatgat 3547741 ttgaagagcc gggcggacag tgtcagcagt tgagtgagca gctccgctta caagtccgtc 3547801 tgcaagtcct ttatacacca gcattgtacc gaagtagttc tcgtctaata atgctttacg 3547861 agcctgttct tcagtcgctt tgcctttgcg gcgttctacg aatgcttgta caaggtcttc 3547921 catgccttca tatgtatgag gatcataaat cttaacgccg cccagcgtaa ggttcaattc 3547981 ttttgctttt gcttggatct cattttcatt gccgatcaca atcggattca gcactttgtt 3548041 tcctgcaagc ttgctgaccg cttctaaaat acgctcgtct aagccttcag gaaatacaat 3548101 tttaacgtct tttccagcta ctttttcttg cactgttgaa aataaatctg ccacaataaa 3548161 acctcctcaa aaagttacaa aaacgctttc ttttactagc atactcttct tccaatcaaa 3548221 ttcaaacagc caactttcat tatagcgctt tcataaaaaa atcttatttt tctaactaat 3548281 ttaagtgact caatcttccc ttataggttc ttctattttg atggagttat acggaaggga 3548341 tgttcaaggt ttctccacag tagaatcgga taaactatgg tatagtgaag gcaatcatga 3548401 aaagataatg ggagtgaaga taaatgagtg aacagcaaat gacgaatgaa gcggcaaaaa 3548461 cgcttgacgg ctggtatgcg cttcatgatt tccgcacaat ggattgggct tcctggaagc 3548521 ttctgtccag tgatgagcgc caatctatca tacatgaatt caccgggttg cttgaaaaat 3548581 ggggcgtagc ccaaaaagaa ggaaaaggat cgcaaactct ttacagcatc gtcggccaaa 3548641 aagctgattt tatgctgatg atccttcgtc ctacaatgga agaattaaat caaattgagc 3548701 ttgaattcaa caaatcaaga cttgctgagt tcaccattcc ggcatactcc tacgtatcag 3548761 tggtagagct gagcaactac ttggcaagcg gtgacggcga tccttatgaa aatccgcatg 3548821 tgcgcgctcg cctttaccct gaactgccgg aatctaaata tgtatgcttc tatccaatgg 3548881 ataaaagaag atctggcaac gacaactggt atatgctttc aatggaagaa cgcagaaact 3548941 tgatgagaag ccacggttta atcggccgca gctatgcggg caaagtcaaa cagatcatca 3549001 ccggctctgt cggctttgac gattacgagt ggggcgttac attatttagc gatgatgtcc 3549061 ttcaattcaa gaagctagtg tacgaaatgc gttttgacga agtcagcgct cgctatggcg 3549121 aatttggttc attctttgtc ggcaatcacc tttcgcttga tacacttcct caattcttat 3549181 atgtataata tcccctcccg ccctatccgg cgggagtttt tcaattctcc tttatcagaa 3549241 tttaaataaa atttgctatt ttcttcgttt tttcttacga tgtagataat aatccatttt 3549301 tttcaaaggg gtgcagttat ttgtcaaaac gaaccgcatt tgttatggga gccagtcaag 3549361 ggatcgggaa agcaatcgct ctgaaattag cagaccagca cttttccctc gtcattaatt 3549421 cgcgaaattt ggataatatt gaatctgtca aagaagacat tttggccaag catcctgagg 3549481 cgagcgtcat tgtccttgcg ggcgatatgt ctgaccagca tacgagagcg ggcatttttc 3549541 agaaaatcga atctcaatgc ggacggcttg atgttctgat taataatatc ccgggcggcg 3549601 cgcctgacac atttgataac tgcaatatag aggatatgac ggccacgttc actcaaaaga 3549661 ccgttgccta tattgacgca atcaagcgtg cttcctcact gatgaaacaa aacgagtttg 3549721 gcagaatcat caacattgtc ggaaatctgt ggaaagaacc cggcgccaac atgttcacaa 3549781 acagtatgat gaatgccgct ttaattaacg ccagtaaaaa tatttccatc cagcttgctc 3549841 ctcacaacat tactgtcaac tgtctgaatc ctggttttat cgctacagac cgttatcatc 3549901 aatttgtgga aaatgtgatg aaaaagaaca gcatatccaa acagaaagca gaagaacaga 3549961 ttgcttccgg gattccgatg aaacgggtcg gatcagccga agaaaccgca gcgctcgccg 3550021 catttcttgc ctctgaggaa gcctcctaca tcacgggaca gcaaatttcc gctgacggcg 3550081 gcagcatgaa aagcatataa aaacatcccg ctttttagcg ggatgtttct tgtaatgacc 3550141 cgaacggcag gttcagcttt tgaatccgcg tgacaaattc ccgcagatcc tcctgcttcg 3550201 acaccattga gattctgaca tgcctttttc cgttgcttcc aaaaatttcg cccggtgtga 3550261 ctacgacatg ggcatgctcc agcaagtaat cggaaaattg gtgagatgtc tcaaacgtat 3550321 tcggaatttc agcccatacg taaaaggttc cttttggctt ttccatcttc cagcccagtt 3550381 ccttttcaca aagcgccgta aaaaagtcaa ttcgttcctt ataaattcgt ttcaacgatt 3550441 ccgtatgctc cggatctcca gaaagcgccg cactcgctgc ctgctgcagc ccgccgaaca 3550501 tgccgacaaa tacatgatcc tgaaattcat tgacggcctg aatgattttt tcgttcccaa 3550561 ccgcaaacgc cattctccag ccggccatgt taaatgtttt tgaaaatgaa taaagctctg 3550621 ctccgacagt tttggcatcc tctgcctcaa gaaagctggc cggtttttga tcgaattcaa 3550681 acgccccgta tgcaaaatca tgaatcaaat ggatgttatg ctctttcgca aaagcagcag 3550741 cttttgcata aaaagccgca tcagccacag ctccagtggg gttgttcgga tagtttaaaa 3550801 acataagctt cgctttttcc agcacggctg gatcaatctt ttcaaaatcc ggcagatagc 3550861 cattttcttc atacagcggc atttcgtaaa gctcagctcg cgccatcgta atccctgata 3550921 aatattcagg atagcctgga ttcgggacta aagcgatgtc tcccggattg agcaggcatt 3550981 gtgtcagcac atacaatccg gctttcccgc ctccgaaaag cgcgacttcc gtttcaggat 3551041 tgattgtcac tccgtattcc cttttataga aagcggcgat cgcttccttt aaaaaaggat 3551101 agcccctgaa agggccgtat ccatgaaacg aaggattcag agaagcctcc cgcaaagcct 3551161 cgacaatatg cggcggagtg ggaaggtcag ggttcccctg tccgagatta atgatatggg 3551221 ctcccgtttt ttccatttcc tttacctttt gaaaaacgag agaaaactcc tgccttggaa 3551281 gtgtcttgat gacatcggac ggtgttattt ccatctaaaa gactcctttt tgctccgttt 3551341 tgttatcccg ttccaaaaac gatttgttga cgagcttcgt atgcaaaaac aaaccgcata 3551401 cgatcacgac aatcagcccc ataatgaccg gagcgcttag gatgttaatg aacattgaac 3551461 caatagaaat gcataatccg atagacgctt cggccactga aaaaatgcgc ccttgaatct 3551521 ggtttgccgc attttcctga accttcactt ttgcaagcac ttccccgtat tccatcgcga 3551581 tgaaaaagag gatcgccgcg atgacagaaa cagcgaatat cggtgtgaat aaaaacagcg 3551641 ccagcgagac aatggataaa acggtaaagt acgtcaggcc tctattgttg ttaaagcccc 3551701 atttgctgac aagcgccgct ccgataaagc cgccgaagcc gatgcagaac gtgagaataa 3551761 agttgccgat ttccccgtca cccagaaagc ggctgacaat cggaaaatag ctgtacacaa 3551821 ctccccacag caaagccatt gtaatcatcg taaacatggc gtttaatacg aatgaattgg 3551881 ttttgatttc cttgagtcct tccttaaaag actgaaaggc ctctttaatg ttttcagatt 3551941 gaatcggcac aaattgcagc ttgatgcggc tgataaaaaa tgccgaaacc aagtatgtca 3552001 caccgttaaa ggcaacagcc agctctacag atccgcctaa cagaaagagc cctccggcag 3552061 ccgccccgac gataatggag atggttgtcg cttttgcaaa taacgtgttg atgcttttaa 3552121 tatctgattc caaggacgac atgacagcga gacgggcggg attaaaaaac acgccgcttc 3552181 cataagtaat aaacagcagg gccagaaaaa tcagcggata ctcgcctttt ggaagaaatg 3552241 tgagccccaa aaagatgatg cctctgatga tatccgtcca cagcatgatc ttaattctgt 3552301 ctaaccggtc gaccagaaca cccaaaaacg gctgaaacac catcggaatg cttctgacca 3552361 cgatgacccc ggacgtcacc caataatcgt gataatatgt agacaaaatg agcagggcag 3552421 ggagaacaca atagtctccc atgaacgata gcgcctgccc gtaaagcaag tatttagagt 3552481 tgggtttcag ctgtttcata ctggcagcac atactttgcc gtcagcttcg catgctgctg 3552541 aatttgtctg attgattcag ccacatcctg tgaattactg cctttcagtt caaatgcagc 3552601 aatggaattg aaagcttcaa acaatgtcaa atcaactgaa gtgcctggtg ctgcggccga 3552661 aaaagaaacg atttcagtat ccccttttaa aagcccgtcc ggaatatcga tcgcttcaat 3552721 gaccaaatcc tcagcagttt caggaatttg gccattttgt ttgaaatgct gcgggtacaa 3552781 atggcagtcg gcaacataat aaggctcttg atccaataat ccgtccggca gatcggcgtc 3552841 ttttccgaaa cagaggacat ctaataataa ttgcgccata tcaaggccaa agaccttttt 3552901 aatattgggg atcatattcc agccggcaaa tctggctgcc gactctatta aacccggttc 3552961 tctgtttttc attagcttga tctctgtatg tgttgcgcaa ttttgcagtc caagcccttc 3553021 atttgccttt ttggcagctt cgacaatttt cttttttgcc tcttcatcca gaatggacgg 3553081 cgtaatgtgg gatgtctctg taaacccgat ttgcggcgtt ttatcatgaa tggcgatcgg 3553141 gaaatactca ccgtcagcca tgatgccttc tatactgata tagtcggagt acccttctgt 3553201 ttgataccag tctccgtact caccctgtaa aaattcttca gcgataaacg gcgcttcaaa 3553261 cgtaaccgcc tttggcacgt taattgattt cagatagtca ttgactctgt taaattcatc 3553321 ttctgccgtc tcagtgtccg taatcagcgt tacaccgata gaactcgcta agtatgtagg 3553381 ctttaagata agaggtgtgc cgatctcttc aagagcagca cggaaatctt caagagttgt 3553441 gactcgtttg tttttgatcg atttgactcc ggccttatta aaagcgtccc tcattttatt 3553501 tttatctctg gcattttcgg ctgcctgcac gccggcacct ctcaagccca gacgttcaca 3553561 ggctttcgcc atcggagcaa tgaataattc attgtttgtt gtgatggcat ccgccccaaa 3553621 catttcggca accttgacga tttgctcgac gacctcttcc tcaggcttgt tatgatcttc 3553681 atgcgcccaa taaatggaat cagggtgttc aaaatcagct aaactcttaa aatagtcttt 3553741 atcttttatg accgcgaccg agtatttttc aatcaatgct gcatgggagg ctgtaattgc 3553801 aaaaggtctt ggaataaagc tgaccaggtt atatttttca gcagcgcttt tataaaacat 3553861 gtgcggcggg cagcctccaa gatcagcgat gaccaatact gtttttctct ccatatgtaa 3553921 aacactcctt ctctattgtg cggtgtatcc tccgtctgcg gtgatggcgc ttccggtcat 3553981 atagcttgat aaatccgagg ctaaaaacag catcacattt gcgatttctt caggtttccc 3554041 aagcctcagc agcggattta ccttcgcttt ttctttttta atctcttcaa gtgtgccttc 3554101 attattttca aggaatgatt tttcattcag cggtgtgtcg atgatccccg ggcatacgca 3554161 gttcacccga atttgatgtt tcgcataatc aacggccatt gatttagtca gctgcaaaac 3554221 cccgcctttg ctggcgttat aagcaggaat atcaggccat gccacgagtc cgccgacaga 3554281 gcacgtatta atgatgttgc ccttgccggc ggccagcata tgcttgagtg catgtttgct 3554341 cattaaaaac atgccggtca aattgacttg cagcaccttg ttccaatcgc tgagctccat 3554401 ctcgtgaata ggcgccacga tttcgatgcc tgcattatta atcaagacat cgagcccgcc 3554461 aaatgtatga accgccgatt caactgcgtg ctggcaggca gcttcgtctg tgatgtccgt 3554521 ttgcacaaag tgcagcctgt cattattttc ttttcgtacc attgcttctc cttgcgcttc 3554581 atcaatatcc gccacaacca cattggcctg ctggcccaaa aaagcctgaa ccgcagcata 3554641 accaatgcct gatgcgcctc ctgtgatgag gacggtttta tcggtgaggt tcatgatcat 3554701 tcatccgcct tcattttttt tgcttttgcc ctgttatagc gcggcgggaa gaagatatta 3554761 atcgattttg attctttttc tgaacggttg atggcaccat gatcttcgcg aggctcacag 3554821 aaataggctg tgccgaattt catctcgact gtgcagcctt cgaccgtcat gtcatagccg 3554881 ccgccgatgc agatgcctat ttgttcattc cgatgtttat ggaaaggcat ttctccgcca 3554941 tttccaggga ttttggcaag cataatttct acccaatcct caacaaagaa cgtgacttcc 3555001 atgcccggca gcaggtctct tgttttgaaa atatccaaaa agtagtcctc aggacttgta 3555061 tatgtttcat cagctttcag ccgcttgata tcaatagcaa tcacttcttg gtctgtgtcg 3555121 tttcttgccc cgtgaggcac atgcggcggc gcgatatagg cagattccaa ggctgtcatt 3555181 tttcttgtca catctccgac agtcatcatc agctcgccag aaacgaccat gccgatttgg 3555241 acctccttat gctgatgggg ttcaacattg gtatgcggcg ggacgtaaga cattaatact 3555301 tcagtatccc ctcgtacggt tgaatactgc ctcactccgt tttcccattc aattaatttc 3555361 ggtgtcggga aataaagctc ctgcatatct tctttagttt tcatcatcaa cgtctccttt 3555421 tccaaataat gaccagctca ttggaatgct tttgaatgtt tttacaaagg ttagcccgta 3555481 cttttgccgt gcaagctcat tggttaaggc aatgtcatac aaaccttctt ttacttttct 3555541 tgcggcttga ctggttgaat tgactagttt gaaacgaaca tctttgcggg taaaatattt 3555601 tattaaatta ataggtgaag gatgtgaaac aataacagat gtatcaagca tatcgtctct 3555661 gaattcaaaa tcaggacgaa cagccaggcc gtacatcggt gtatcgcacc tgaagatctg 3555721 caatagctgc aaatccggcc tcatgtagaa atgcttaatg ccatcgtaag catgtgggac 3555781 gatggtatat tccagcgggc tttggagcgt cctttcgatg cacgattcaa aagtatcatg 3555841 caaggacaat ttactgttca gcccttgtag aagagtaaaa ttggaaatga aatgctttgc 3555901 tgcgtactca ctgcttgtcc cctcagggcc gagcgtgttg actgtaatga gtttggatag 3555961 tgaatcagtt cttttttttg tctgaatgct attatccaat ataatcatga gcaccaacca 3556021 atcttttaaa attttaagta aattttatcc agtggaaatt gaactgtcaa tgttttttga 3556081 aaatattgat aattattccc atacaaacaa aaaaaccctt taaaaagggt ttttaattat 3556141 aggaatttag aaactttgtt tattgagata aggactgatc ggccttctgc tcaagtttgc 3556201 cgtacttttt atatgcgaat acactgagca caaatccgag gactgtgatg gcggcgcaaa 3556261 tcaatccgac agctgcatag ccgtatgcca catatacggg tcccattaaa gcagaaccta 3556321 atgtcacggc cagattcgag gcgagactgt aaaacaccat gacttttcct cgatgacgct 3556381 ctgagcagtc actcaaaatg gtgctgagca gcgtcaccgt caaactttgc attaatcccc 3556441 aaataaatag gctggcgatt aacagaaaca tagacgccgg cgcatatggt aaacacgcca 3556501 gcagaacgct gatgaccccc agcgcaatca aaagggagcg catttttccg atgcggtcgg 3556561 ctatctttcc tgtaatcaca ctcatggaaa acccgattcc ataaatcatg ataaataagc 3556621 ccgcagccgt gtttcctccg gtaaaaacgt cctgaagata ggtgcctaaa aaggaataca 3556681 taccgtaaaa accaatcata ttacaaaagg ttattgtgat ataaacaggt acacgaggga 3556741 ctttcagcgc atcccggaat gttcctgcgg gctcttctat ttcttccttg ccgctgtttt 3556801 tatgttgggc atggcggcgc atttcaagga gaatcagcag aacaactaaa acacccatca 3556861 gggcgaaaat ccaaaacgtc catctccaat gcaggacgcc gccgataaat gatccgagcg 3556921 gcactccgaa aatcagcgcc agcgaccagc ttgaaacgat cagtcccatc accttgcccc 3556981 ggtatgtata aggaacacga tcaccgacaa ctgcgtaagc ggtcggaaca aacgctcccg 3557041 cagccaatcc cgaaagcgcc cggcctaaaa agaagaaaaa aatattttga gctaaagcgc 3557101 atatcaccgt tcctatgata aaaatcataa gcccggccaa taagctcagt tctctggagt 3557161 atttatcgcc taatggaacc aaaagcggcg caccgataaa aatcataacg ccgtaaatac 3557221 tgatagataa cgcaaggacg ctgacatctg agctgaaggc ttttgctaaa tccggcagca 3557281 gcggtgagat cacaagctct tcagatccgg ctgcaaatac ccccatcgtt aaagccagtg 3557341 ccaacaataa cggaaaatga tgttttgttt tgatgtcatt gttttgattg ctgttcattc 3557401 tttctcaaac acctcttcca taatcttctt atcataaagt tgtattatag tttagcattg 3557461 ttttttctct atttacaatt cgaacgaaat atttataagt tttattattt tcatttaaat 3557521 cccattatat atttctatat ttcattctaa aaatacatga ggatgtaaca cgtaaaaaaa 3557581 gctctccggc ctcccggaga gctttttcta ttgcgcctct gtctgctttt tttcaatcgt 3557641 ttcatgattt atacgctttt tgatgcttag atgatagtat gcataacaga aaataatgat 3557701 cggcacaccg cagtataagc caattctttg atccggaatg aaaataaggc tgatcaacac 3557761 gcagccatat aaacaaaatc cgagaatcgg gactagcgga taaagcggcg ttctgaactc 3557821 cagatcattc acatttccgc cttctgccag gaaacgcctg cgaaagaaaa attgcgacgc 3557881 acaaatggac atccacgcga caactgtcac catgcccgag attgagatac accataaata 3557941 cactgtttct gcagccatga cacttgtcag cagcgaacag cctgaaatgc ctagcgtaat 3558001 cagcagggca ttcatcggca cgcctttttt tgtcagtctg gtgagaaagg agggacccat 3558061 ttgatttgat gaaagtgacc acatcatacg cgacgccgca tacaatcccg aattagcaac 3558121 agataaaatg gccgttaaga tgacaaagtt catgatatct gccgaaaatg ggatgccgat 3558181 ttgatcgagt actgctacaa acgggctttc aatcaccccc gccgttttgt acggaaggat 3558241 ggcaaccaag acgaacatag cgagcacaaa gaaaaacagc gtgcgccaaa taacatttcg 3558301 aatggacttt ggcagtgttt tttccgggct ttcactttcc cctgccgcaa tgccgacaag 3558361 ctccgttccc tggaacgaga agtttaccat gaccagcgta aacataacgg ccagcacccc 3558421 attagggaaa agccctctat cagtcataaa gttagacaaa aagggtgtct cctgtccgcc 3558481 tttaaagtca atcaagccaa acacagcggc tccgccaatc acaataaata atatgatcgc 3558541 cgccactttg atgcttgaaa accaaaattc catttccgca aagcttctga cagagagcgc 3558601 attaatcaaa aagatgacga tgccgaacac gaggcaccat atccagatcg gaacggaggg 3558661 cagccacctt tgcatcaaaa tgcctgctga cgtcagctct aaccctactg tattggccca 3558721 gctgaaccaa tacagccagc caatcataaa gcctgtcgac tgtcccagaa atttagtggc 3558781 gtaggcctga aacgatccgg ccaccggcat ggcaacagcc aattctccta aacaaagcat 3558841 gacgagatac attaaaaatc cgccgatgat atacgcggca atggcgccga gcggtcccgc 3558901 ctggctaatg gtaaagccag agcctagaaa cagcccagtg ccaatcaccc ctcccaaagc 3558961 aatcataaac aaatgcctgc ttttcatgct gcgctgcaat tcatttttat gattctgcat 3559021 catccttccc cctttggttc ttttgccgtg atggtcatcc ggtagctttg caaaagatga 3559081 acggtggttt gctgtatgag gagaggcaat acatgaaatg tgtacggttt atagactcgt 3559141 tctgtccatt tatggccgtc ttttccgtac acgcccatat taatggatgg aatattcagc 3559201 ttgcgtatgt ctttgaacgg aatggtccca atcatattcc acccagggaa gttcctgata 3559261 aaagaatcaa tttcgccatc ggtttcgtgc agtgataaaa aactgccgtc tgccaagtag 3559321 gggaaaaact ttttgaagac aaatgtttcg cctgtcgatt cagcggtttt gtcagccgct 3559381 tctttaatca catgctgcaa aagctgatct cttgcgctat cttctttcaa atagttatgc 3559441 ggcaggtaag gaggtgcgta aaatagaatg acttttgcgc cttgatcggg gtcaagcttt 3559501 tgaagctctt cgattgcctg aaagcatctc atgcgaagtt caaggtgctc gttggctttg 3559561 aatgtctgct cgatacactg ctcgggatct attccccggt ttctcagctt ttctaagtat 3559621 tgctccaggc tatacacttg aatgccccat gataaatgtt tctttggcag gttggctctt 3559681 tttacatatt cttcgtaata atctgataat ttttgttctg tctcccggca tgcttcctca 3559741 gtgacttcaa taagcaaatc catcatttct tttgctgttc tttcataaat aaaacaattg 3559801 aaatacaagc tggtgctgac agccgtttgc acattatagg attccttgtt atcacgctga 3559861 tacaaacagg atgggggcag aaccaactcc ccttcaacct tttctgccag atggatgtta 3559921 ttgtggagac ggcttgtgat ttcagatgaa atgaaatttg ggtcaatccc tgccagtgta 3559981 tcgccaacat ggacttcacg cccgtaaatg taaaagcaag gcaacagttt tcccgcggct 3560041 ccggtataga tatatcttgt ctgatcacca tcgtaaagcg gggtaataaa atccgtatta 3560101 atagcagcca aatagtgaag ctgtttttct ttttttagcc ggttcagctc tgaaatgctg 3560161 gcgagaatgc ccgaatgctg gctctcctca tcgggattgg ccataaacaa tacatttccc 3560221 ggcaacgtct caaggttctc cgaaaaatgc aggagattgg ctaaatgcac ggcgatgccg 3560281 ctttgcatat cgacagatcc tcttccgaac atccactcgc ctgatttggc atcccgctga 3560341 acatcctgat cgaactcata gcggctgaaa tactcggcca atttctcaca atcaaaagcg 3560401 atatccttta aagggccgaa atcttcaatt ccaactgtat ccagatgggc atggtaaatg 3560461 actgtatttc ggctttctcc atgtccttta ataaacgcaa aaatattttt gcgtttgtat 3560521 gggtcattgg gaatggcctg ttcccacaca tgactggggt tttcctgaaa ataaggatag 3560581 ctcgtgatca cttctttgat gaaatctgct tttgtccctt ctccaacggt gccgttcacg 3560641 ctgctgaggc tgaccagaga tgctgtcagc gcctccactc tttcagccgg attcatgtga 3560701 ctgatttttg tatactgcat aaattgtcct cctgatcaaa aagttgaaat cgtgcgatcc 3560761 gctaaagaat cgcacgattt tatttctctc aaatcaaaaa gcttcggacg ttgttttggc 3560821 ttgcatatga agaattaagt aatcgggacc gcctgctttt gagtctgttc ctgacatatt 3560881 aaaaccgccg aacggctgat agccgacaat tgctccggta catcctctgt taaaatatag 3560941 gtttccgaca tggaaatcct cgcgcgcccg ttcaatgtgc gcacggtttt tcgtcagaag 3561001 cgcacctgtt aatccgtatt ccgtgttatt ggcaatctcc agcatatgat cgaaatcacg 3561061 cgctttgcaa atcgcaacaa ccgggccgaa aatttcttcc tgcatcaagc gggcgttttc 3561121 atcaacatct gcaaagatcg tcggctgaat aaagtagcct tttgaatcat cgccttctcc 3561181 gccggccaat agcttgcctt cagatttgcc gatttcaatg tatttcatca ctttgttgta 3561241 ggatgcttca tgaatcacgg gacccatata cgtatcagga tcttctggat tgccgacagt 3561301 cagcgttttg gtcagcgcca cagctttttc caccacttca tcatacacat cctgatgaat 3561361 gaccgcgcgg gagcccgcag aacacttctg tcctgaatat ccaaatgctg aatacacgat 3561421 agaggatgca gcaaggtcaa gatcagcgtc cttgtcgaca agcactgtgt cttttccgcc 3561481 catttctgca attacccgtt tgagccattt ttggcccggc tgcactttgg cagctcgctc 3561541 ataaatccgg cagccgactg cacgggaacc tgtaaatgag acaaaccgtg tcttcggatg 3561601 ctcaactaag aaatcaccga tctccgcacc atctcccgga atgtaattca gaacgccgtt 3561661 tggcagaccc gcttcctcca tgacctcgac aaattttgct gccactaccg gggctgcgtc 3561721 agccggtttt aagagaatcg tatttcctgt cacaatcgct gccaccgctg ttcccgccat 3561781 aatcgcgagc gggaagttaa atggagaaat gacgatgccg acgccaagcg cttcgtaatg 3561841 atattgattg acctcgccag cacggctctt caccggagcc ccttccttga gctttaacat 3561901 ttggcgcgcg tagaactcta aaaagtctat cgcttcagcc gtgtccgcat ctgcttcctt 3561961 ccacggtttt cctgcttcct tcacaagata gcttgaaaat tcatgctttc ttctgcgcaa 3562021 aatagccgct gccttaaaga gaatatttgc gcggtgctcc ggtctttgtt ttttccagga 3562081 atcaaatgcc tgcaatgcgg cttgcatcgc tttttcagca agctcttgat ccgctgtaga 3562141 cgcgtaccca atgatctctt ctttatttgc cgggttaata gaaatgattt tgcggtccgt 3562201 ttcaattttt tctccattta tgacaagcgg ataatgcttg ccgagctgag tgtttacaaa 3562261 ggccaatgac tccccaaatg cagttttatt ctttgcttcc gtaaaatcgg taaatggttc 3562321 gtgcgcgtat gtgactgtca tatgtagtcc ccctcgtgtt atgaaatata tcttcgcata 3562381 tgaataaaaa tgcaagaatc atgccatttt cttgtctttt gctgaaaaaa cttgttgaat 3562441 cgaacagaaa tttgtctaac aggtgatcac ctttctcttt ttccgatctt gaacgcaaat 3562501 ttattttgcg ttttttgctc tttacgcaaa aaacaaatgc aaaattattt tgcggaggct 3562561 tctcaaatta gacccatccg cggaaacgcg atgcttctgc cgattttctg atgcccgtca 3562621 tgtaagccgc caaacgcata tccactttat gtgttgccgc tgtttgataa attgtttcga 3562681 acgagctgac catgacgctt ctcagttttt ctgcaacctc ttcttccgac caataatatc 3562741 cttggttgtt ttgcacccat tcaaaataag aaaccgtgac gccgccggca ctcgctagga 3562801 tatccggcac aagcagcacg cctctttcat tcaggatctt agtggcatca atggttgtcg 3562861 ggccgttcgc cgcttcaacg acgattgacg cctgaatgtt atgtgcgttt ttggctgtga 3562921 tttgattgga gatcgcggca ggcactaaaa tatcgcaatc cttttcaagc agctcctcat 3562981 ttgtgatgac gtcagtaaat aaattggtga ccataccaaa gctgtcccgt ttatcgagca 3563041 aataagggat atcaaggccg tctgggttgt agagcccgcc attggcatca gaaatcccga 3563101 tcaccttcgc gcccgcatcg tgcatgaatt tggccaggaa gctacccgcg tttccaaagc 3563161 cctgtatgat gatgcgcgcg ttttgcagct tgatcccttt tttcttcacc gcctcttcaa 3563221 tacaaatcgt gacgccctgt gccgtcgctg tttcccgtcc ttgcgatcct cccaaaacaa 3563281 gcggtttacc tgtaataaag cccggagaat cgaattcccg cagccggctg tactcatcca 3563341 tcatccacgc cataatctgc gaattggtgt acacatcggg agctggaata tcctttgtcg 3563401 gaccgacgat ctggctgatg gcacggacat accccctgct cagcctttcc agttctccaa 3563461 atgacattgt ccgcggatca caaataatac cgcccttccc gccgccgtaa ggaagattgg 3563521 caatcccgca tttgagcgtc atccaaatgg ataatgcctt tacttcctct tcattaactt 3563581 ctggatggaa gcgaacgccc ccctttgtcg gaccgacagc atcattgtgc tgtgaccggt 3563641 agcctgtgaa cactttgacg ctcccattgt ccattttgac cggaatgcgg acagtgagca 3563701 ttctctgcgg ctctttcatg agttcataca tatctcccgg ataacccagc ttccgaaggg 3563761 cttccttaat gattgtttgg gtagacagaa ataagttaag agcttctttt tcttcatctt 3563821 tcgagacttg ctttgctgac atctttttca cctcattgtt tttttggccg gctgtaatgt 3563881 aagcgcttta aaaaatcagc ccgccaattc ctttcttcat tggattcacc cttatcatca 3563941 tgcaagatcc gtaccagctt ttgaatccac aaaaaaagag actgaaaaca tctcagtctc 3564001 tgactacaaa tctatcgatt aacggggatc aatcaccagc tgcgtttcag cataaaaact 3564061 gccgattccc aaaccgttta ctacatcgcc tttaatcgtg taagtgcctg cgcgaggaag 3564121 agttttacgc accatgacaa ggtcaaattc ggatgcgcct aacaaatcaa gcgtaagcgg 3564181 gagtctgact gtttttccat cgtttaaaat ctgtgtttct ttcagtgttc ttccattcac 3564241 tgaatctctt gtcgtagcat gaaacccgtc aggaaattga aattctaccg ctccaagaga 3564301 aagcaccgca tttggtttat atgtcacttc aatatcagaa atggtccact ctttcgtgct 3564361 gttaactgtt tttgcctcga ttgatgcaga ctgtgcatga gcttggcccg aaggaagtaa 3564421 gattgatagt aaaacagctg aactgatgaa taatgaagat acgaatgaag ttctttttag 3564481 catgacattt ccccctaatt gattgttgaa atttggccag agcgtcctct gcagaaaaag 3564541 cgctttttca taattcgcga attaccagtt ctttttctta aaaattaatc tatcatcatt 3564601 ttccatggaa gtaaatgttt tttaaggaat attaacactt ggaattcaat gagaattcct 3564661 tcctgtttat acaaggttca aatggacgat ttccctctct ttttctagta acatctgcct 3564721 gacattttat atcttttatc ctattttaaa aaagggcaaa aaaagtcgaa gatgcctctg 3564781 ctcttcgatt gatcacgttc ctatttttat ctgaattcag tgttccagtt aaaaccgatc 3564841 gtctcatcat cccacggaat tcttttttca tcaggctgat ccgggttata cgacatggtg 3564901 gtaaaataga taattgtcag cggcgtctct cccagcactc tatatccgtg agccacccct 3564961 tttgggatta ataacagcat cgggttgtct tcgcccatat aatagacgtc cgtttctcct 3565021 tttgtctttg aatcctctcg aagatcgtat aggacaacct gagcgtggcc ggttgggaag 3565081 aaccagagat catcctgctt ctcatgataa tgaaatgcct taatcacacc cggatagctt 3565141 ttcgaccaag aggcctgccc aaaatgctca aggagattct catcgtcccg gaccagctca 3565201 gcaaaaaagc ctctgtcatc gctatgcttc atcaattttt tcaccttgac tccatcaatc 3565261 acacgcactg ctcctttcct gcaaatactc tcgtaacgct tcccgccagt ggcgggggcg 3565321 gatgccggct tcttcaatag cccgatggct cagcacagag tatgccggac ggggcgtttt 3565381 gttcccgtat tcctctgtcg ttacagacaa aatggctgtt tccagcccgc tttcttccat 3565441 aattgccgtc gcaaactcat accagctgca tatgcctgaa ttgctgacat gatagatgcc 3565501 cggcggatgg ctgaacagct tgatgaccgc ttctgctaaa tccttcgtat aagtcggcga 3565561 accaatttga tcgctgacaa cccgaagctc ttgtttcgtt tcagcaagtt tcagcatggt 3565621 ttcaacgaaa ttactgccgc catgtccgta cacccacgat gtcctgatga tcgtgctgtc 3565681 ttttgtcgtt aatcgtatca gttcttctcc gagccttttg cttttgccat aaatggtttt 3565741 cggatcgagg ggatcgtctt ccctatatgg ctgggttcct ttcccattga atacatagtc 3565801 cgtgctgata tgaacatatt gagctccgat gcgggttgac tcaagcgctg tataataagc 3565861 gccgattccg ttaatcaagt acgctttatc aagctctttc tcgcattgat caaccgacgt 3565921 aaacgcggcg ctattgacca cgatatccgg ctgataatgg ccaaacgaat gccgtactga 3565981 gcgctggtca gcaatgttca tcatcttctt tgttaacgca atgacctcat atccggcttg 3566041 cttcagctgg cggcatagtt ccaagccaag ctgtcctccc gccccagtca ccaatacctt 3566101 tgtcaatcag atcaccttct catcggtcat tgtctgtata ccactgaatc gtacgcgcaa 3566161 tgccttcttc aaacgtcact tcctgccgcc agcccagttc gtttttcagc tttgatgcat 3566221 tgatcgcata gcgccggtca tgcccttttc ggtcttccac gtgggcgaac aattcctcac 3566281 agcccagatg cttcaaaatg acactcgcca gctctttatt cgtgcgttca tttccgccgc 3566341 cgatgttata cacctcgccg tcggtccctt tttctaaaat cagcttgatc gcgcggcaat 3566401 gatcctccgc aaacagccag tctcggatct ggagtccatc gccatacagc ggaacaggca 3566461 ggccctgctt cgcatgacgg ataatcgtcg gaatcatttt ttcgctgtgc tgataaggtc 3566521 cgtaattgtt gctgcatcgt gtaatgatgg ccggaagctt gtgggttttc acataagaca 3566581 acacgagcaa atcagagctt gctttgctgg ctgagtatgg gttattagga gaaagcggcg 3566641 tcgtttctgt aaacgcggga tcatccgctt ttaaatcccc gtatacctca tctgttgaaa 3566701 tatgaatcag cttcttggct tttcctttca agaccgcttc cgccaatcgg tatgtcccca 3566761 tgacatttgt ggtgataaac ggctccgctt gggaaatgct tctgtccaca tgcgattctg 3566821 ctgcgaagtg aatgacgcca tcgtaggtct cgtcaaaagc gcggtcgata tcctcctgaa 3566881 cgctgatgtc cccttttaca aagcgaaaac ggctgttttg ctttaatttt tccatttcct 3566941 ccgggtggct ggcgtacgtc agtttatcta aaacggtaat gcgcgcatcc gtttccctca 3567001 gcatgagctt tgtaaacgtg agcccgatga agccggcccc gcctgtaatt aaatatgatt 3567061 ttgccatcac ttttcgtcct gtcctttccg taaagcctgg tgtacaagct gggaagcgag 3567121 ataaagcgat tcgtgagttc cggcatctac ccaccagcct gataacacat catacgtaag 3567181 ctggctgttt tcgatgtata gattattcac atcggtgatt tccagctcgc cgcgctttga 3567241 tggtgatatt tgttcaatat atgaaaacac ctctgcatca tacatataaa tgccggtaac 3567301 acaaaggttg gtcggtggct gttcgggctt ttcgatgatg gaacgaatcc gcttgttttt 3567361 ctcatcaatc tcagcaatcc cgaaacgttc cgggtcatca acttctttca gaagcacttt 3567421 tgctcctttc ccctgctgtt caaagcgttc tgtataaggc tttaatgaat cttcaaatat 3567481 attatcacct aataataaaa tgaaagactc ttttttcgta aagcgctttg cataagacag 3567541 cccatccgaa atgcccgatg ctgccggctg tacttgataa gtgatagtaa cgccaagctc 3567601 ttccccgttc ccaagcagtt tgtaaaattg cggcatatgc tccttttggc tgatgagtaa 3567661 aatgtctttt attccggctt cctgcagctt cataatcgac cagtatatca tcggatacgg 3567721 gcctacagga agcaaatgct tgttgacggc tttcgttaag ggcataaggc gtgagccgtt 3567781 tcctccggct aaaataacac ctttcacatt aacacttcct tacatgcatt tttatatctc 3567841 ttgttcatat aaatcttgaa gaatagctgt tacccgtata atgcctttgc catccacgag 3567901 cggccttcct cccttgtgca aagaaaggcg aagaggatag ctgctcataa tgcgtgacat 3567961 ctgatagatg agtgtttcat ccggtacaag ctcacccaat ccaagatcaa gagcggcgcc 3568021 ttggtcagca aatgttttgg ctgtagccgt ttgatgctca acctgagaaa gaacaaggca 3568081 cggcacgccg atgcaaatgg cttcatatag agagatgccg ccagcgacaa tggctgcgtc 3568141 cgcttgtttc atcaaacctg ccatatcatt tgtctgttcg atcatcttgt actgcggctt 3568201 cttttcgatc cgccttcgga ctgcctcttg atgcggtgaa gcgctcccca tcacaaacat 3568261 catgtttttg tcttttatgt cggggacttg atcagcggca gccagcactt taaaaataag 3568321 ctgcttcgga tcacttcctc ctaatgcaac aaggatattg cggcagtctt tcttaagtgt 3568381 gtaatcctct cttgcggcct gaaaggcggg gtgaagaata agatagtccg gaccttcata 3568441 gatgcgtgtg tttccctgaa cgtacaccct gcttctgatg tcaccgtaaa ttccgttaat 3568501 gactgcgtca ctatattgaa tcgatttacc gtttttctct tcaaaaagaa caattttcgc 3568561 atctgtctcc gtctttattt tctttaacag ctctgcaggc gcgcctagaa tatcaaacaa 3568621 aagcaaatca agcttcttgc tttttatttc ccggagaata aattcgtgct gctgcagctc 3568681 cggctttacg atgacctgcc aatgctcttc atgaagaaac gcttcagaat cctgattcgt 3568741 ataaaacgta atcaagcatc gctgtttgag cccctccgca agcctcttca tccggacaac 3568801 atggcccatt cccttttcat agccgccgtc tgcgaagatc ccaacatgca tggctagtca 3568861 gcctctcgtt cggttgccgc atcggggttc cggttcagaa gggtgataag ctctgaggcg 3568921 gatacatcgg ggcgctcgcc tgctttttga tagagggcct ttatcgattc atagtcttcc 3568981 tttgtatcaa tggtcagccg atattgaggg gcgcgaaatc gttccggcgc ctctaaaaac 3569041 tgaacacgat aaagagctgg atgattcctt atatataacg tgacatgctc ctgatattga 3569101 tcctccaaag cctgaatacg gctgatgtca attaacaggt tggcgttgac cacttcgccg 3569161 caaatcccta atggggcatt caggatatac gtataatccg agccttgatc aaaatgcgcc 3569221 tgaatcatta catcgagcag ctcaggatcg acaaacggat tatcacctgt taaccggatg 3569281 atgactgacg gtttaacagc ttctatgacc ttcacaaacc tatcgaggac acgttcttcg 3569341 ctcccgcgga aaacacgaaa gccttgtttg atacagtgcg cctctaatat gtcgtcagtt 3569401 tctttgtcag acgtggcgat gacaagatta tcccgatcct tttggtaaaa cgcgctttgc 3569461 cggacacggt gaacgagaat atcaagtaaa cgattcgatc cgagcggccg aagcactttt 3569521 cccggaagcc ttgttgaacc cattcttgct tgaatgataa agagaatatc attcatgaaa 3569581 cgggctgtcc ttcagtaaaa tgtcatccca gacaatgcct gtgtcggctg gaatgtctct 3569641 tacagcccga acaccgctgg tcagcagttc aaaaaatctc gggtgcagcc cctgcggctt 3569701 ttgtccgggc cgaagcactg cgatattgtc ttcactaaag gcttcacctt tttgaatcgg 3569761 agctgttgta aaaatgcctc tgtatgcaaa gtttctgatt tctccttcga tggcggtcgt 3569821 tgttttgtat gaactgccaa gcagtttttc agagaccggc tttgtgatcc cctgtttcag 3569881 ctcagcttcc gttttcctga tgccatcgac catttctttc aattcatccg gatttaatgc 3569941 aaacgagtgg tcagcacccg gcagattttt atcgatcgta aaatgctttt ctatcagttt 3570001 tgctccgagc cgaaccgcgg cacacggcgc ttctgtcgga tgctcgctat gatcggagaa 3570061 gccgattacc gcctcaggaa aagcggcggc aagcatcgga atgacgctga ggttgctgta 3570121 ctccggcggt gctgggtatt tcgccacaca atgcattatg gcaatttgat tgtttccctc 3570181 tgccctgatg gtgcgccaag cttcgtgaac atcagagatt tcagctccgg ctgtcgagaa 3570241 aatcatcggc ctgttcagcc gggcgacata tttaagcagc gggagatggt taatttcata 3570301 ggatgcgatt ttaaaagcgc tcggcgaggt agactgaagc agatcagctg acccctcgtc 3570361 acataccgta cttaaaaaga tcacctgctt ttcgcggcag taatccaata gcggtaaaat 3570421 ccactcagca ggcatttcca tagattgaac caaagaaaaa atagagacgt ccttgcccgc 3570481 tgccgtcttg tacaaaccag gatctttctg gtacatccta tcagcttgga acatttgaaa 3570541 tttcacggca tccgctcccg cttccgccgc ggcgtctatc agcgcaaaag cctgatcaag 3570601 cttcccgtca tgattaatcc ccgcctcagc aataataaaa acaggagcgt ctttgcctac 3570661 agttttattc gcgatctgaa acgctgccat tatttcgcct ccttgcccgg ccaaatatga 3570721 taatagtaat acgattgttc agcggtgaag cccattcgtt cataaaggcg gatcgccctt 3570781 acattgtgaa gctgcgtccc cgctgttacc gttctatgct tctgggtctc cggttgttct 3570841 atgagattcg ccaataaatg aaacgcaata cgtttccctt caaatcccgg ctttacagcc 3570901 atcaaatcga gaatgcactc atcatctctt gataagccct gaagatagcc gatgacctcg 3570961 ccattgtgtt tagcgacaat attgaccgcc gcccttccat tcagattgtt tcgtgtccac 3571021 tcctgaaata tttcgtttgc tgcatcgcgg ctgagatgag gatcctgaaa atatctgctt 3571081 tttgtaaacg agtctcgggc cagctcacat atcgcttctg tgtctccggg ctcaggcggg 3571141 cccagttcaa aaaatggcgg tgttttgtca taaaaagacg gaggcatcgc cagcttcagc 3571201 aaactcccga caaagtaaga ggatggctgc tgttgtatca catgcgcggc tccgatatct 3571261 tcagccggaa cacggacaaa gataaaatcc gtttcatcca tttggcgtac agtataaaaa 3571321 gcttcaaaca gcctctttag ctgcccggta ctatttgccg caagaagttt gacgttcatg 3571381 actttcttct gaagcacctt gctttcccac aaagaatctt cgtaaagcaa tacgccttgg 3571441 agcctgctgt tttcaaaaag gccgagggaa aattgatacg gaacatccaa tgtaagcttt 3571501 ctgctttgga gaaattcctc aattgcctct ttggagacat tttcttttac cgtatacact 3571561 taatcagccc cttttacgat atcccgcaca gcttcaatga catcatctac atcatcgtca 3571621 gacattgatg gatagagcgg gagagaaagg gttcgtttat agtaattcat ggcattcgga 3571681 aagtccgctt ccttatatcc aaattgcttt tgataatacg gatgaatgtg tactggaata 3571741 aaatgaacgc tagtgccgat attgtattca tcctttaaag ccgtaatcat ttcgctgcgc 3571801 gtaaccccgg cctttttttc atcaacttgc agaacatata gatgccaggc gtgcctgccg 3571861 tcatcatgga caaacggcgt gatcagccca ggaatctgct gaaaagcggt ttgatagcgg 3571921 ccggcaatct cttctctccg tttctgcata tcatccagcc gtttcagctg atgaagtccg 3571981 agggccgcct gcaaatcaaa catattcatc ttatagccgg gcgattcgac ttcatagtac 3572041 cagctgccat ttgaagaata acggttccat gcggctttac tcatgccgtg aaggcttagc 3572101 acccgtatct tatcggcaag ctcctcatca tcagtcgtca gcatgccgcc ttcccctgtc 3572161 gcgaggtttt tggtggcgta aaagctgaat gccgttgcat ccccgataga accgatcatt 3572221 ctttgcttat aagtcgtata taccgcatgt gccgcatcct ccagcacgaa taaaccatga 3572281 ttttgggcaa cagccaatat tgcatccata tcgcaggact gcccgccaaa gtggacgggc 3572341 acaactgctt tcgttcgcgg tgtgacggcc gcctcaagct ttaccgggtc aatattgagc 3572401 gtgttttcgt caatatccgc aaacacaggc gtcgctcccg tatgaataat cgtattggcg 3572461 gtcgagctga acgtaagcgg agaggtaatg acctcgtccc cgggcccaat cccttttgct 3572521 ttcaaagcca aaaataaagc tgcggtacat gaattcaccg ccacggcgtg cttcgccccg 3572581 acaaacgcgg caaactcttt ttcaaactgc tgaaccttcg ggcctttaga gagccatccc 3572641 gattcaagcg tttctgtaac ctcctgaatt tcttccttac cgattaacgg caatgagtaa 3572701 gggagaaaat gatttctctt ttgcaccatt tctttgcgct cctatcattt tattcagtat 3572761 cttcccgcct gtaatcaacc cctgttttgg ctttcagttc cgcaaataaa gcatttgttg 3572821 attctgccac cggataatta gccgctatga atgccaggcg cgcctcttct gctttttgat 3572881 gcacgtcggg acttcgaaga acctcaacca aggtgtgcgc cagttcatcc ggctggtcaa 3572941 acataaaatc gccaagagac tcataatacg gatacgagcg atttccggac gattttccta 3573001 tcagcacagg cttttgaaac agcatggctt caagaccgac tgtcgaggtt tgcgtcactg 3573061 cggcatcaac atacggcagc aaatcataaa gctccagctc ctttttgatg actctgcatg 3573121 cttgatgttt tttcgccgcc tcgtgataca gatcaagctt gttttttccg atttcccacg 3573181 ggtggggttt gataatgatt tgcagctgct tctgatcaga aagcccctgc agcacaccgg 3573241 aataaaagtc ttctgaaaag ggctgagtgg caatgagcac aattttttta gtcggctgaa 3573301 aagcaagttt tcgatagaat atggacatat ccataggcgt tctgttaaaa atctgatcga 3573361 agcggggatg tcccgttacg agaatctgct cgggtttaca gccttttcgt atgaaccact 3573421 ctgcttcata cgcaccaaaa acagcttgat aggttgtaaa aacaggaatg aaggcttcat 3573481 ctcccatcaa tgcgccatgc tgaagacaaa tgctgacggc cccttttctt tgacacatga 3573541 gagcgagcac cctgctgtaa atgtcttctg ccgttccgac aataacagct gaaatctttt 3573601 cctgttcaaa cagcgcatca actgtatcaa tggcctctat aaataaagga atatctttga 3573661 aaagccggtc gcgaaacgct tgatcaccaa atgccgggtg atcatcataa ggggcgagaa 3573721 gcgaacaggc tgtttcgaga tactgcttcg aatcgccttt ttggcatgaa tccgcaatct 3573781 cccgcttgct aattacaggc agatcacaat aatgcggcaa actccatctg gccaaaacag 3573841 ccgttttttc aggatcaaat tgatagtaat tttcgtttga aaaacgcagg taatcaaagt 3573901 gcaaaatgac tttcccttta acaggttcgt catttgtttt aacgatgttt tggattcttt 3573961 cttcaaaaaa cggctgaatc tgtccctcat cgatatgctg atccaccgat ccgaataatt 3574021 ccggttcttc ttccatcatc accctcagtt cagggctgat gtattgataa aaattactga 3574081 taagcccaag cggaatccct ttgtagcgaa gtttgtcaaa aagctccacg tacttccggt 3574141 acagcaccca ataattgctt aaataggccg acaagctctc accccattcc aagctttttt 3574201 aatgattcac gcagctctcg gcaatttcgc tgcggaggaa ggttcctgac aaattcattt 3574261 ttttctaatt caaacagctg aaagtgaatc gattggtcgg taatataatt caggtccagc 3574321 tcctcatcca gtgggtaaaa cggataaaaa tgattgactc tccaaaagaa ccgggcatct 3574381 cctatacggt aaaacgccgg gctttcatcc caataggagc caaacttctc ctttaccttc 3574441 tcaagcaccg aatacctgtg catcaccgag caatgatcaa ttgcgcacgg cgcgttccat 3574501 gtcacttgag cggcaggcct gacagtttct tttacaatgt cacgattctc gtttaaatga 3574561 taggttttgg aggctgagta aatcacagcc ttttcaggat gggtatcgag ctcccgcacc 3574621 attttcagga ggcggtccgg catatagatg ttgtcatccg tcgcataggt gatatattca 3574681 ccctccgcca tctcaatcgc ctgattgatc agtgccgcgt atctcgtttt ttctgttctt 3574741 tccttcactc cagatatatc gctttgataa aaacgcactc ggttatcatt caaaaaagga 3574801 cggattacat tcagcgtctc ttcattggag ttgtcatcca taataaacaa ttcaaaatct 3574861 gaaaacgttt gtgagagtat gctagaaatg gactttgcca cataatcgct tttgttatag 3574921 ctcgtcataa tgactgatac tttaggcaaa tcctacacct ccttcttgga acttcacacc 3574981 tgaaactatc gttatcttat gttgcttatg ctcaagttgc gctagggata caaaccaata 3575041 tgcgaaaagt ttgtgtatgt ttctgaaaaa cagcggctgc ccagagcgaa atctgatcgg 3575101 tccgctgttc tttttcagca taatccaagc atcagcctca taaggtgaaa gagataaaaa 3575161 tcgcaccagc gactaagatc gttttccatc ggaggtgagt catcgcggag cgttcaccta 3575221 tacatccaga acatgttttg aatggttttc ataaaaagga ggaacgatat gaaaccgaaa 3575281 aaaaatcaat atcagcaaat gcaggcattt gataatatgc aggggtatca gcctcagttt 3575341 ggcgccaacc cgtacccgca gcaaggccaa ggctcacaaa tgcagacaat ggggatgcag 3575401 ccaatgatgc caatgcagca gggacagcaa ggacaacaag gacagcaggg atttggattc 3575461 ccgggccagc agcagggcgg cggttttcaa attccatcgg ggcctacacc gtcaggaccg 3575521 ggccaaagcg ttcccggcat gctgcctgtt gaggaatctt acatcgagaa tattttgcgc 3575581 ctgaatcggg gaaaaacggc caccatttat atgacatttg aaaacagcaa ggaatggggc 3575641 tcgaagattt ttcgcggcgt catcgaagct gcgggccggg atcacattat tatcagcgac 3575701 ccgaaatcag gaacacgcta cctgctcctg acaatctacc tcgattacat tacatttgat 3575761 gaagaaattg cttatacgta tccatattcc atggcgtcct attcgccaag ataagaaaaa 3575821 agccaatcac tcatatgatg aggattggct tttttgttta tagatatttg acggctgcga 3575881 caacgatcat aatccaagaa ataataaacg ccacaccgcc gagcggggtg atcgctccaa 3575941 gaatggagat ttgcgtcaca cttagaatat ataagcttcc ggaaaacagc acaattcccg 3576001 caaacatcag ccagccggct gtcgtgacac tgcctatgcc ggataattta tcagccagaa 3576061 acgcgacaac gaataaccca agggcgtgat acatatgata ctgcacgcct gtgtgccaaa 3576121 cctgaagata cttatcaggt attttccctt ctaatccgtg agcgccgaat gctccgagtc 3576181 ccacggcaag cagggcgtta atggccccta atatgataaa aactttcatc tatctctccc 3576241 gccttttcgt taaactcata tcatttatct tatcgcacct gcaccaaaat tcaatgtttg 3576301 ttctccgttg acacgagatt gtcggatttt ctcctgcgcc aaagctggaa ctggtcagct 3576361 gctattgcag caagcgtccc taatacgagc ccgttgctta atagagaaat aaataccgga 3576421 tgcaatccct ttaacgcagt ttcaggaaca aacatgatac cgacccctgt cagcagtgag 3576481 ataccgatga tagacctcac cctttttgat tcttctttct catatgaatc aaattcggca 3576541 aaggccagac cgcccattgc ggagaacaca acaaaattca ccgcaaatcc aacgggtgac 3576601 ggcaggctcg caaacgtatt cataaaaaac gggatcacgc tgatcacgat aaccagaata 3576661 ctgccgagca taaacggttt tttagaaggc atcttggtcg tttcaataaa acctgcggct 3576721 cccgaaatcg gaacaggcgc aatagctccc gtcaaaccgc taagcagatg gctgaatgaa 3576781 gctgcaaaac cggcatggcg ttcatgatgc tttccatcag gctgtttgct gaattttttc 3576841 atggcgatgt ccacgacctt catgctcgcc agcatattca cgatcagcaa gatggtaata 3576901 aaaatagaag tgatgatcag gccgctgtta aataacgggg tcccaaaagg aaacagggaa 3576961 ggcagctgaa acagccggtc cggcatttca atcggctttg cggctccggc agccgcaaac 3577021 agcacccacc cgccgaacaa ggctaataaa atagaatatt gcttaaaaaa catgatgttc 3577081 gaatttgtca ttataaaagc ggcagcgatc acaacaagcg ccaggccaaa tacaagaccg 3577141 tccaccccgt cctgtcgata accgattccg agaattcctt ttataatggg ctgactcagc 3577201 tgcatgacaa gaagcaataa atagacgccc gttacaaccg gagtaaacaa ttttgcaagt 3577261 ctgtcaatga ccttgaaaac acttaacaaa aagaaacata cagcgcttac aagaagagct 3577321 ccctgcaaac cccgcagtgt gtctccatat gtcgcaaaca cagttcccgt cagccctgcg 3577381 taaatcgtat acactcccca ccacaagccg gctgggcttt cattgatcgg cagtctgtgg 3577441 cctttcaaac actgaatgac ggcggcaatt cccagtacaa aaaaagtgct ttgaatcaat 3577501 cttgcagaat ctgagtgatc cagatgaaac gactgggcaa ccgccaccgg aacaacaatc 3577561 gccgcagcaa taataaacgc tgtccattgc agcgcgccaa gaaccaattt cacgtaagct 3577621 caacctctct ctttaaaaat caaataaaga ctctccgttt ccatcctctt cctgcttctc 3577681 tttttcttgc tttcgatatt tgtttaatcc cgcgctcccc atcatttttt ccatcatcag 3577741 ctggtctgtc gatggcggcg cggcgggact tggcgtaacg ctcggctgta tgcggggcgc 3577801 gctcgcgttc tccggctgat caagcacgac atcacacaga gaacggacaa ccgctacata 3577861 acgcttcagc tcctcatccc gttcagccgt ttttgctttt tttagctctt cttccatctt 3577921 ttgaatcaaa gcagatatat gaatgttcat gaagcaccct ccaaaaaaat aaatgttgtc 3577981 ttcctgcatt ttatcaaatt cctgctgaaa acgcagatat gagtttgtta ttttttctga 3578041 caaaccttgc gcgattgaca agcagaagag atttttcaca taataaatca ccatacctta 3578101 caaaaaggag aaacggaatg aacagcatcc cctctatcat cagcaagcat aaagcctatt 3578161 ttgcggcggg acatacgaga ccgcttgaat cgagactgaa cattttgcga aagctgaaac 3578221 aagccgtcag aactcatgaa gccgatctca tagccgctct ctaccaggat ctccataaat 3578281 ccgagcaaga agcatactca acagaaatcg gaatcgtctt ggaggaaatc agctttgtca 3578341 tgaaacggct gagaaaatgg tccaagccga aacgagtcaa aacgccgttg actcatctag 3578401 gctccaaaag catcatcatc cctgagccgt atggaaccgt tttggtgatt gcgccttgga 3578461 actatccctt gcagctggcg ctttctccgt tgattggcgc cattgcggcg gggaacacgg 3578521 tcgttctcaa gccatcagaa tatacgccgg ctgtttctgc tattctttcc aaactcatca 3578581 gcagcgtttt tccaactgat tatgtcgcta tggcagaagg cgggcccgat gtcagcacag 3578641 cattattaca gcagcccttt gactacattt tctttaccgg cagtgtagct gtaggaaaaa 3578701 tcgtcatgga ggccgccgcc aaacaattaa ttcccgtaac cttggagctc ggcggcaaaa 3578761 gtccctgcat cgtccataaa gatgctgaca ttcagcttgc cgccaaacgc atcgtcttcg 3578821 ggaaatttac aaatgcggga caaacctgca tcgcaccgga ttatttattt gtccacgagg 3578881 acatcaaaac gaagctcaca gaagaaatga agcgtgcgat cagagaattt tacggccctc 3578941 agccggaacg gaatccacag tacggcaaaa tcgtcagtga gcgccactat cagcggctgc 3579001 tcagctttct gaatgatggc atcccgctca caggcggaca atctgatccc aatcatcaca 3579061 aaattgcgcc gaccattctc gaacaagtga gagatgactc tccagtgatg caggaggaga 3579121 ttttcgggcc gattcttccg ctctttacat accgcaatat cggggaagtc attgagaaag 3579181 tccaatcgcg ccctaagccg ctcgccctgt atctcttcac cacaaacaaa gaaattgagc 3579241 gcgctgtttt aggaaatctg tcgtttggcg ggggctgtgt caatgatacg ttaatgcatg 3579301 ttgcgacgcc gtatttgcca ttcggcggcg tcggggaaag cggcatcggc agctatcacg 3579361 ggtttgacag ttttaacaca ttcacgcaca aaaaaagcgt cgtcaaacaa acgaaccgtt 3579421 tcgacttcgc atttcgttat ccttcctcca aaaacgggct gcgaatgatt cgaaaaatac 3579481 tcaaataaaa aagcgcagat cacctgcgct ttttacaaat ccttaataca ccaatcaatc 3579541 ggcgcctctc ccattttctc caaataggca ttcgcccggg aaaacggtct gctcccgaaa 3579601 aatccgtttc tcgcagaaaa cgggctggga tgcgtcgatt caatgataaa atgcttggag 3579661 gtgtcgatcc gttctttttt catttgagca tgccgtcccc acaaaataaa gataaccggc 3579721 cgctctcttt cactcagcac gtcaataatt cggtccgtca gtcgctccca gccttttccc 3579781 ttatgggaat tcgcctgtcc gcgccttact gtcagcacag tattcagcaa aagaacgcct 3579841 tgctttgccc agctcacaag cgacccgtga ttcgggatgc tgcacccgat gtcctgctgc 3579901 agctcaagaa agatattttt taacgaaggc ggctgcttta caccgggctt gacagagaag 3579961 cttaaacctt gagcctgtcc cggcccgtga tacggatctt gacccaaaat gacgaccttg 3580021 acatcatcat atgatgtata atgcagcgcg ttgaaaatat cccggctgtc cggataaatc 3580081 gtttgctccg cgtattccct cttcagcatc tctctgagct cttgataata cggtttctca 3580141 aactcttcct ttagctgatt ccaccagctg tcttgtaaaa gctgtttcaa gattcaggcc 3580201 tccttacgaa cgatgaagtc tggaatagac aggctcgcca tcccaaacca tttcactttt 3580261 tgcttcccgc ctcttcatct caggctcttc aagcaggacg gcaaagtttt tcgtcggcag 3580321 ctccccgagt ccgtgctttt cacttaaacg atccaaatat tgcttccgct tggcgccaag 3580381 gtcagcagac tgattgtctc ccgcgtcact gaaggcataa atcacgctgg cgcaagggac 3580441 acgcttcacc cggtaatcct tggccgcgcg caaataaaaa tcccagtccc agtaattgtg 3580501 cacatcagca tcgaaatacc cgatttcatc atgcagaaaa cgtctgtaca tgctgcccga 3580561 cggcacgtat gtagaaaaca ctctcatatc ctcatagtca gcggtataag caaacaattt 3580621 ccgtgacact ggataccttg ttccgttttt ctcttcaaac gaaactattt ccgcatcaga 3580681 atgaacgaag tctgccgttt ctatttcctt tgccattttc tcgatatgcc ctggcgtaaa 3580741 gaaatcatcg tcatcacaca gcataatgca atccccagac gcctctttta caccggcatt 3580801 tctcgcagcc acatgccccg agttcttttc taaattgatg acagcaatcg gcagctccgg 3580861 ataaagtgct ttgaccggca cgaccgattc cccggcatca ttcacaataa taatttcata 3580921 cggcatcaag gtctggcggg aaatcgactc caaaagctca cacaaagccg gaatccgatt 3580981 ataggtcaca attacgatag aaatcttcat gatgctctcc ttctcatttt catagtcatg 3581041 tactattaaa acatatattg gacgggagat cagtgggaat atcctactga aacggcatac 3581101 tacaatgata gaaacagcaa agtggctccg atcagaagca ccatgatcag catcagatct 3581161 ccaaagacat gaaagatatc tttcatgcgg acgccattcg gaaggataag acgccacagc 3581221 ttagattgat agaccggcag cagcaccagt gcataagaaa gacacaaaaa tgtaaaagcc 3581281 ggcggcacaa aagcacagcc tgcatcgtcc caattcatca tgatgtcttt catactagat 3581341 ccatccaata aaaacaaaga tatcatgagg gctagcaaca caaaggaccc caattgaacc 3581401 tcaaacaggc gcattttctg gttatatgca aatcggaccg cccaaaacca gacataagca 3581461 tatgaacata gcagcgtaag aatggcacct gctgtaaaga cgacatcagg cagccgatca 3581521 agcagaaaaa caaaaggcaa gctggctgcc atagccaaga gcatgcagcc accagtaaac 3581581 aaaaatactg ccccatgagc tacaaaacca tataaacaag agctaatcct cacgacatac 3581641 acctccttta catagaaatt ctatgtatat acctaaaaaa tcagacaagc tgacgcctgc 3581701 caatataaca gcccattcgg ccaaataacg gaaataacag cgttgcaaaa gcacaagttc 3581761 caacaaacca aggtgtcaac aaggattgaa acagcgcagc aggaattaca ttgaatagaa 3581821 aaacaagcat aaaaatgacg tttggcacca ttgagatcag aatcgtatgt agaacaagct 3581881 tttctccgcg ttttccaaac tccttcacgc cttgataccc aatcagcacc cagtagatca 3581941 tatatgcagc taagatcagc caaacagaaa cagaaatgcc tttccatact gcttgaacaa 3582001 acggtgattc aagccataca tgcattattg taatcgcaat gccgacagcg aatagggcac 3582061 tgttacagaa aagatggaac atcaaaaacg cacgaaacgt tactggctgt attttcttaa 3582121 acgaagaaac aatgtcagtt ggtgttccaa acgcctgcaa taaagtctgc atagcttcct 3582181 cctcactctt tccttcctga aaagagcgaa acagatgatg ttcaatatgg ctctcaatct 3582241 cttctatcat cgcctcaccc tcaggaagcc ctttaagccc gcttttgatt tcggatacat 3582301 atgtttcttt atccattttg tccgctccac ttcagtattc ggtccatcat ggctgaaaat 3582361 acgctccatt ccttcgtgcg ttccgccagc acttctttgc cctcgtctgt aatccggtaa 3582421 tatttgcggt ccggtccttt ctcctgcttc tcccagtagg aagaaatata cccttggcgt 3582481 tcaagcttgt gaagagaagg atacaaggtc ccttctttca tctgcagttc atttccgctg 3582541 cggcttccca tttcttttac aagctcatag ccgtacatcg gccgctcgtt cagaagcgtc 3582601 aataccaata taaccgtgct tcccttaacc agctcacgat ttaacatctc aaaaccccta 3582661 cctagttttc ttatgtagca ttttacgaaa gcccgttgag attgtcaaat gattcctata 3582721 gatcttctat attgtgatac agagaaaatc taactataat gaaagacaaa acatgatgga 3582781 ggttcaagac atgtctatgc ataaagcact caccattgcc ggctcagatt ccagcggcgg 3582841 tgctgggatt caagctgatt taaaaacatt tcaagaaaaa aacgtatacg ggatgaccgc 3582901 cttaacggtg atcgttgcga tggacccaaa caacagctgg aaccatcagg tattcccgat 3582961 cgatactgat acaatccgcg cccagcttgc aacaattacg gacggcatcg gcgtggacgc 3583021 catgaaaaca ggaatgctgc caaccgttga cattatcgag cttgcggcaa aaacgatcaa 3583081 agaaaaacaa ttaaaaaatg tggtaattga cccggttatg gtttgcaaag gtgctaatga 3583141 agtcctttat ccggagcacg cccaagccct gcgtgagcaa ttggctccgc tagccactgt 3583201 cattacgcca aacttgtttg aagccagcca gctcagcggc atggatgaac taaaaacagt 3583261 tgacgatatg atcgaagccg cgaaaaaaat tcacgcactc ggcgctcaat atgtcgtcat 3583321 tacaggcgga ggcaaactca aacacgagaa agccgttgat gttctctatg acggagaaac 3583381 agcggaagtc cttgaaagcg aaatgatcga tacgccttat acacatggcg caggctgtac 3583441 attctcagca gccgtgacag cggagcttgc caaaggtgcg gaagtcaaag aagccattta 3583501 cgcagcgaaa gaattcatca cagcggccat taaagaatcc ttcccgctaa accagtatgt 3583561 tggtcctacg aagcattctg cactgcgcct gaatcaacaa tcataaaaaa aggggctgcc 3583621 ttacagagag gcagcccttt ttaaatcacc gaagactttt cacagaaaaa actgccgatc 3583681 ccatcggcag cctgtttatt tgatttttaa attgtttgca gatttcctca aaaatgtttc 3583741 tatcgactga acaaaaagtg catattcctt catttgttca tatgcccgcg tgagaatttc 3583801 cgccgtttca ctgtgcggcg ttgttccgcc aagcattttt ttcagctgaa gcagcacatc 3583861 cttatattct tctcgcttat cttcaacttg gttagcagcc ttttccaaac attccggtgt 3583921 tatcttctgt tcatgtatat tcaagaaaac aactcctttt acagaaaaaa atagtaggtt 3583981 atcgttgaag aatagcacag atggctcaga tttcacataa gaaaatagaa ggattttcta 3584041 cataagtgtc caaattccga cattcatttc agatttcccg gtcgcactgg ctgttacttc 3584101 atgatttccc gggaaaggaa aatatcttgc actcaagacc tcttctccgt tattgataaa 3584161 gatttccaca gatgacgcgt cgagaaacat gtgtacggta tgcaaatcct tgatgcggca 3584221 atgtctcgct tctgttcttt ttccgtcaaa gctctttcgt tccagcgtaa caatcccctc 3584281 gtctttatgg aaggaaaacg tagccgttcc gcggatactg attgaaaagc cagactccgt 3584341 atgaatgtct tccagtagaa tctcagttct ttcaggtttt tccactggaa gcgcaccaga 3584401 tgatccatgc atgttgatgt gtattttttt ctcatttctg cgcatggctt ttagctcagg 3584461 cagcggctgc tgaatcagct tctgtcctga aagcgtcagc tgtctcggca gcgtcatgca 3584521 gtgaatccag tggcagtcaa tggtcggatg ggacccttca tcctgatcag gcaccgccat 3584581 ccatgcaaat aaaatccgcc ttccctgatc gtcttcaagt gtttgcggcg cgtaaaaatc 3584641 aaaaccttga tcaagctccg taaattcacc atgcttcagt tcaggcttgt tataatcgag 3584701 gcggccgaca aaataacctg attgatatac gttctgataa cggaaaccgt cagcctcaag 3584761 cccttgaggc gaaacaatca gcacatccga tccttgaagg gaaaacaaat cagggcattc 3584821 ccacatgtat ccaaaatcgt ccagcccgtt gaagcccgcg ccggttatcg ggccaagaaa 3584881 tctccactct gtcaggttat cagaagcaaa caacacagcc tgccctttca aattctctgt 3584941 ttgcgcacca atcaccatat accatgtgcc ttcatgctcc cataccttcg gatcgcgaaa 3585001 atgcgccgta tatccttccg gaaggcgggc gacgacaccc tttttctcaa aggacagccc 3585061 gtcgtcagaa acagcaaggc attgatacgt ttcccgattt ccatcctgat ccctgacatt 3585121 tcctgtgtaa aaaagataga gccgatcgtc tttcgtgaca gcgctgcccg agtagcagcc 3585181 gtttttatca aaccaatcac tcggagccag cgcaatctct tcccgcttcc aattcacaac 3585241 atcctgtgtc gtataatgcc cccaaaattt tgcgccgtgc cccgtctgaa acggctgcca 3585301 ctgaaagaat acatgatagc tgcccttcca ataaatcacg ccattcgggt cattcagcag 3585361 cccaaccggc ggcatgatat gaaaatgctg gcggtgcgga tcgctgttag cgatgggctc 3585421 ttttttctcc acttcttcat aagcccggcg acgaagctcc tggtcatgtg ctgtcatttt 3585481 ttcctctcct catcctcatt aatcttcatg acaaatgctg caatgaacgc tgacactgcc 3585541 gcaatcgcca tgccaatcag atagtgaatc aagttgctga agccaaacgg agccgcaatg 3585601 gcgatcatcg gaattcccgt taacccgtaa gcgtttgcag ctacatgtgt aaagacgaca 3585661 tatgccccac ccaatgcgcc tccgatcatc gcggcgataa acggttttcg gtagcgcaga 3585721 ttgactccga atatgacggg ctcagtaatg ccgagaaaag cggaaaatgc tgccggaagc 3585781 gcgatttctt ttgtctttgc ctttttcgcc ataaagaaga cggcaagacc tgccccgccc 3585841 tgtgcgacat tcgccattga ccagatcggc agcaagtagt ttttgcctat atctgcaatt 3585901 agccctgcct caatcgcatg gaagctgtga tgaacgcctg tcagcacgat gagtgaatac 3585961 gtgcccccga aaatcagacc tgcgacaaaa ccggcatggt catatacata agttaaagca 3586021 accgtaatgc cggagccaag cgctctgcct agagggccaa tcgcgataaa agcaacaaac 3586081 ccggtgacaa tcacagtaac aaatggtgta acaagcaaat ccaccgcatg tggaaccact 3586141 tttctcgtcc atttctctac cttgctcatc acatacaccg caagcaggac agggataaca 3586201 gttccctggt agccgagaag agcgatatca aatccgaaaa gatgcatgta atcaggtgtc 3586261 gcttccgcca atccccatgg atttaaaaga ttcggatgaa tcatgattcc cccgatgacc 3586321 gctcccaagt atggattgct gccaaactct tttgaagcgc tgaccccgat tagaatcggc 3586381 aagaaaatga atgctgcact tgaaaacata tcaagcagct gcaaaagcgc agaatccttg 3586441 ctcatccaat gaaacgcatt gatcataccc agcaatccca ttaataggcc gctggctaca 3586501 atagctggga tgattggaac aaaaatatta gaaagcgttt tcgcaaatct cgcagcggga 3586561 ttcagctttt cttttgccgc atcctgatga ttgacgtgtt cttcacgctc gatatcagct 3586621 tctttagaaa aggcatcgaa tactttattc acaaggcctg ttccgaaaat gatctggtac 3586681 tggccagagc tgctgaaagc ccctttaacg ccatcaagct cttctacttg tgcttgatct 3586741 atctttgatt catctttcat cactaaacgc agtcttgttg cacaatgagc cgcgctgata 3586801 atattttctt tccctccgag aagctcaatg aggcgttttg cagtctcttt gtaatccatc 3586861 tatttctccc ccttttattt aaacaaaaaa gacctaaaat tcgccaacga ataaaggaca 3586921 cagcgatcct ttttcattta cgcaaatttt aggtcttgcc tgctttacca gtcacaatcc 3586981 cgcttattca gattaagaat acgctttcat cataaatcat gatagcgttt tcgtcaacta 3587041 tttttttagt taaatagttt gatataacat gtagacaaaa attcgtaaaa attaattgtg 3587101 aaatacttca caatatcgtg ctatactatg ctcaatcatg aaagaaagca ggaaaagaca 3587161 atggaaactc aagcattaca aaaggttgaa cagtatgctt tgaaaaaaca aaacatattc 3587221 gcttcaagca aaatccgtta tgtgcttcgg tccattttgg ccagtatatt tattggtttt 3587281 ggcattacag ccgcaagcaa aacaggcagc tatttcttta tggctgattc tccgtttgcc 3587341 tttccggcag ccgctgtcac tttcggggcc gctattctga tgattgctta cggaggcgga 3587401 gatttattta ccggcaacac cttttatttc acctataccg cgctccggaa aaaaatcagc 3587461 tggcgcgaca ccctatactt gtggatgtca agctatgccg gcaatttaat cggcgccatt 3587521 ctgtttgcca tcctgatcag cgcgacggga ctttttgagg agccttctgt tcattccttt 3587581 ttgattcatt tggcagagca caaaatggag ccgccggctt ccgaattgtt tttcagagga 3587641 atgctgtgca attggcttgt gtgcctcgcc tttttcattc caatgtctct caaaggggaa 3587701 ggagcaaagc tttttaccat gatgcttttc gttttctgct tctttatttc cggctttgaa 3587761 cacagcattg ccaatatgtg cacattcgcc atctcgcttt tgatcgagca ccctgataca 3587821 gtgacactga tgggagcagt cagaaactta atccccgtta cgctcggcaa tctgaccgcg 3587881 ggaatagtta tgatgggctg gatgtactac acactgaatc ctgatcaata aaaaaacttc 3587941 cagagatcac tccctgcaag tcaaagcggt tattccgaga gatcttgaag acgctggaca 3588001 tgcagcgtga tatagccggc ctcggattcc ggcaaatgta attgatattc atttttcaaa 3588061 aactccgcca gctccagcgc acattgatag gcgaatgaat actttttttg gatgaaataa 3588121 agcatctcct cgtccatacg atggagcgct tcatttgatt ccaaccggct gaccgcgtat 3588181 cgcaaatgcg tgacaaggcg ttgataggaa atgctgtttt catccacctt tcgattaaag 3588241 tattgtttta ttttctctat catttctttg atcatggtcg tatgcttcag cgctgaatac 3588301 atgctctccg catccatctt cgccgtatgg atgtgaaggg caatataacc cgcttcatct 3588361 tcaggcagag acacgcccaa tgtctctttt acatgtccga tcgcccacag gccgatctca 3588421 tattcttttt tatagagcgc ctttatctca tgcagcaatt tattctgcac aagcagccca 3588481 ttttgaatcc tttcgatcgc aaaggacaaa tggtcggaaa gcgcgatatg aatgtgatcg 3588541 ctcagcggcg ccgcgagctc tccttccgca tagctgatga tatcctcagc tatttctata 3588601 tgctcctccg gcagtgtttg caggatttgt ttgaactttt cattctcgtc gcgcacgaca 3588661 aagatctttt ccactttatt catagggatg agatcatttt tctttttttg aaaagcgatt 3588721 cccggtccca tcacgatttt ttcctgatca tcctctttta ttaaagccgc attgttgttt 3588781 aatactttat agattttcaa gaggttatct ctcccgccaa tttgcttttg actgggattt 3588841 tacctccttt tgaccgccat gtaaagatgc gggcccgctc tctcctgctt tggcgattcc 3588901 ttgaaggctt gcaaacatct tcttttataa agcgcggcgg ctttcgcttt ctgcttttct 3588961 tcctcattca cagccatccg ccattcataa aacgaaacga gtcctgcggc ctgcacagcc 3589021 gcctttcttt ggtatgtacg ctgagccgaa tagaccgcgg cagccgcagt ttttctgtcc 3589081 ggcgtcaccc agttcatcaa aaagaccatc cacacccgta aagatacaag caaacgtttc 3589141 atagaaaaac atccctccgc ttctttttgg caggcagcct ttttagcagc ccgttttctc 3589201 agccgcagcc cgcaagaaaa gacggccgat ttcttttctc gcaaactagc ggctctagca 3589261 aaactcatga ctctatgata gaccgtggaa agagaattct ttgtcacaat atgagtgaaa 3589321 aaaccaacta gtttttagaa gttttgttga aagctgaaag aattgaaatg aaaattggag 3589381 aaccgctttg aaaactttat acacaagtta tcccaaagat aagaacaact taatcacaag 3589441 agatatccac atgtccacaa actctatcta tattttgtat acgaacgtat attcctaact 3589501 atatatatac acaggtttat tcacttatac acagggttct gtgtataact ccttcgttat 3589561 acacaaacaa aatccaataa atggtccaaa tgacacaagg atttttttga attttcaaga 3589621 aatatatact agatctttca cattttttct aaatacaaag ggggaaacac attgaaaaag 3589681 gggatcattc gctttctgct tgtaagtttc gtcttatttt ttgcgttatc cacaggcatt 3589741 acgggcgttc aggcagctcc ggcttcttca aaaacgtcgg ctgatctgga aaaagccgag 3589801 gtattcggtg atatcgatat gacgacaagc aaaaaaacaa ccgttatagt ggaattaaaa 3589861 gaaaaatcct tggcagaagc gaaggaagcg ggagaaagcc aatcgaaaag caagctgaaa 3589921 accgctcgca ccaaagcaaa aaacaaagca atcaaagcag tgaaaaacgg aaaagtaaac 3589981 cgggaatatg agcaggtatt ctcaggcttc tctatgaagc ttccagctaa tgagattcca 3590041 aaacttctag cggtaaaaga cgttaaggca gtgtacccga acgtcacata taaaacagac 3590101 aatatgaagg ataaagacgt cacaatctcc gaagacgccg tatctccgca aatggatgac 3590161 agtgcgcctt atatcggagc aaacgatgca tgggatttag gctacacagg aaaaggcatc 3590221 aaggtggcga ttattgacac tggggttgaa tacaatcacc cagatctgaa gaaaaacttt 3590281 ggacaatata aaggatacga ttttgtggac aatgattacg atccaaaaga aacaccaacc 3590341 ggcgatccga ggggcgaggc aactgaccat ggcacacacg tagccggaac tgtggctgca 3590401 aacggaacga ttaaaggcgt agcgcctgat gccacacttc ttgcttatcg tgtgttaggg 3590461 cctggcggaa gcggcacaac ggaaaacgtc atcgcgggcg tggaacgtgc agtgcaggac 3590521 ggggcagatg tgatgaacct gtctctcgga aactctttaa acaacccgga ctgggcgaca 3590581 agcacagcgc ttgactgggc catgtcagaa ggcgttgtcg ctgttacctc aaacggcaac 3590641 agcggaccga acggctggac agtcggatcg ccgggcacat caagagaagc gatttctgtc 3590701 ggtgcgactc agctgccgct caatgaatac gccgtcactt tcggctccta ctcttcagca 3590761 aaagtgatgg gctacaacaa agaggacgac gtcaaagcgc tcaataacaa agaagttgag 3590821 cttgtcgaag cgggaatcgg cgaagcaaag gattttgaag ggaaagacct gacaggcaaa 3590881 gtcgccgttg tcaaacgagg cagcattgca tttgtggata aagcggataa cgctaaaaaa 3590941 gccggtgcaa tcggcatggt tgtgtataac aacctctctg gagaaattga agccaatgtg 3591001 ccaggcatgt ctgtcccaac gattaagctt tcattagaag acggcgaaaa actcgtcagc 3591061 gccctgaaag ctggtgagac aaaaacaaca ttcaagttga cggtctcaaa agcgctcggt 3591121 gaacaagtcg ctgatttctc atcacgcggc cctgttatgg atacgtggat gattaagcct 3591181 gatatttccg cgccaggggt caatatcgtg agcacgatcc caacacacga tcctgaccat 3591241 ccatacggct acggatcaaa acaaggaaca agcatggcat cgcctcatat tgccggagcg 3591301 gttgccgtta ttaaacaagc caaaccaaag tggagcgttg aacagattaa agccgccatc 3591361 atgaataccg ctgtcacttt aaaggatagc gatggggaag tatatccgca taacgctcaa 3591421 ggcgcaggca gcgcaagaat tatgaacgca atcaaagccg attcgctcgt ctcacctgga 3591481 agctattcat acggcacgtt cttgaaggaa aacggaaacg aaacaaaaaa tgaaacgttt 3591541 acgattgaaa atcaatcttc cattagaaag tcatacacac ttgaatactc atttaatggc 3591601 agcggcattt ccacatccgg cacaagccgt gttgtgattc cggcacatca aaccgggaaa 3591661 gccactgcaa aagtaaaggt caatacgaag aaaacaaaag ctggcaccta tgaaggaacg 3591721 gttatcgtca gagaaggcgg aaaaacggtc gctaaggtac ctacattgct gattgtgaaa 3591781 gagcccgatt atccgagagt cacatctgtc tctgtcagcg aagggtctgt acaaggtacc 3591841 tatcaaattg aaacctacct tcctgcggga gcggaagagc tggcgttcct cgtctatgac 3591901 agcaaccttg atttcgcagg ccaagccggc atttataaaa accaagataa aggttaccag 3591961 tactttgact gggacggcac gattaatggc ggaaccaaac ttccggccgg agagtattac 3592021 ttgctcgcat atgccgcgaa caaaggcaag tcaagccagg ttttgaccga agaacctttc 3592081 actgttgaat aagaaaaagc cctgccgatt cggcagggct ttttaaagat cagtcagcaa 3592141 acgcctcctg caataagcga tacgatcgga gcttatcttc aaaatgatgc gtgatggtca 3592201 ccaccatgat ttcctctgtt tcatacgcgt tactcaaagc taacagccgc tccttaacct 3592261 gttctttcgt accaacaatc attcgatttc gattatcagc aattcgtctc tgttcataag 3592321 gagaatacgt atttttccga acagcttcat acgaaggaac tccctctaaa ggaataccct 3592381 gctctcccgc caaaagtgta aaatcaagca cagccccaag ctcctctgcc ttctcctccg 3592441 tgtcagcaca aagaacaaaa acagcaactg ccgctcgagg cgtatctcct aacacagacg 3592501 gtttgaatcg cctcttatac tgtctgacag taccctctcc gccctctcca ttgataaaat 3592561 gggcaaacat atagccagcg ccagattcag ctgcgagcag cgcgctttct ccagatgagc 3592621 cgagcagcca cacatccgga gccgttgaaa tatgcggcgc agcggtcaga ttcggaaaac 3592681 ggtgtttgtc atccgccaaa tcatgcaaat acatggtcag ctccttaatt tgctgcggat 3592741 actgatcagc attgcgctta ccaccgtcat tcagcgccca tgatgcaatc ggcattcccc 3592801 ccggtgctct gccaagcccc aggtcaattc ttcctggtgt cagcccctcc agaacacgaa 3592861 agttttcagc tactttataa gcactgtaat gcggcagcat gactcctcct gatccaacac 3592921 gaattcgctt tgttttcgct gctatatgac tgattagcac ctcaggactg gaccctgcca 3592981 gccgttttga aaagtgatgc tcagaaaccc aaaatctctt atatccaagg tcctcagcag 3593041 cttgggcaag cgcaacggtt tgctgtaagg ccgtttctgc attgctgccc tctgatactg 3593101 gagattgatc taatatactt aatgaaacca tccctaccac ctcatcctca tcgtatcact 3593161 gatcccctat tttttctcca aagccgctca cactgcttat cagtgtcccc tatcattcgc 3593221 catttatttg tgaaagcatg tccctatttg tcggaatatg ttacacgtga aacataaaaa 3593281 cccctccaga cggagaggtt tgctttagtt tttattaaag cccttttctt tcacgtagtc 3593341 atttaaatac gtacgcggct tttgcttcat aaagttcagt atttgatcgg accacgtttc 3593401 ttcccgcttc ccgtttgttc tttctctata gtaatcagaa atggttttgt catacgtatt 3593461 catagtatga cggaaatcgt ctgtgttcac attatacgta ttttcatgat aaacggcctg 3593521 ctttggcaat ctcggttttt tgccggaaag gttcgcagga tggcctactg ccagtccgaa 3593581 aagcgggagc acatggtcag gcgtttgcag cacctctgtc accttgtcca attcattccg 3593641 aatgccgccg atatagcaaa tgccaagccc catggattca gcggcaatgc tcatattttg 3593701 cgctgccagc gccgcatcaa tcaagctaac cataaacatt tctgtattct cgagcagctc 3593761 agaaatatgt tcaccttttt cctcagccag ttgttgatgg cggtacaaat ccgcacaaaa 3593821 tacaaaaaag tgtccgttct tctcaacgta aggctgattc ccagcaagca cggacagctc 3593881 acgttttttc tcaggatcag aaaccccgat aatcgaatat gcctgcacat agctggatgt 3593941 agacgcagcc tgcgcacttt tcactaatgt atcaatttct tcagctgtca aaagctgatc 3594001 agtaaaagac cggattgacc gatgattcaa aatggtttcg attgtgttat tcatcacaaa 3594061 aacctcctta tcacttttta tcatatccga aaaaaagtga tctcaaaagt gaaatgctct 3594121 gcacaaaaaa agacagcctc tgtaaaggct gtctgcatat caagaattaa aaagataact 3594181 tctgtatttc gtcagctgca cacttgcatt atatacaatc ccaaatccga ttaacgtgga 3594241 aagtgtcgag cttcccccat agctgacaaa cagcagcgga atcccggtaa caggcataat 3594301 gccaatgttc attccgatat tctggaatgt gtggatcaca attaacgccg tatagccaac 3594361 gcaaaagaaa gaagcgaaac ggttaaacgg atgtattttg tctatcagaa caacaagcct 3594421 gtagattaaa aagaagaaca tgatgacaac aattgcacag cctataaagc caaatgactc 3594481 acctattata gaaaagataa agtcagtcgt actctctgga acataaacct tcaaattaga 3594541 aataccatta cctaaaatac caccagatcc tattgccatg atggcctggt caacttgcca 3594601 gctgtcattt gaatcttcct gtgtctcatt tgaagcagac acccaagaag tgacccgctt 3594661 aatttgataa tcctgtattc caactgattt agcaacgtca ggaaagttta tcattactaa 3594721 taaaattaat gaaatgagta agatacctga accagctatg atcgcaatca atttccaatt 3594781 tatccctgac ataaaaacca ttacaagaac gataaacata catattcccg cagtcccagc 3594841 atcctgcatc aggataagac ctacaggaat aactgcgaca cccgcaatct ttaataacaa 3594901 gtggatatca tccctaagcg tccgaactcc tttaggattt gcttttccaa taactgaagc 3594961 aagcatcata atcaaaccaa ccttcataaa ctctgacggc tgtattgtta ttctaccgat 3595021 cctaaaccaa ctttttgccc ctttaataac aggtgcaata gactcgggac tgattttaag 3595081 aataatcaaa gataaaatac caatgataaa aatatataaa cttaactttt caagctgttc 3595141 taaatcaaag tacaaaagaa ctgtaatggc tacagccccc aaaagataaa acacaatttg 3595201 ctgaatccaa tccgtgttcc catactgccc aaactgaccg gcagcatata ttgatactac 3595261 gcttataata aaaaacacac caaatataaa aatcaaatcc ccctggtaaa aggggctttg 3595321 ctgtttctta tatcgactca ttctatcccg ccttacattt tcatcggaaa atcactaatg 3595381 tttattatac atgaaccacg ttcaagatga cacgtgaagc tcgcttcctt ttatgttttt 3595441 tcagcatttg cggcgctttt tcagctacac gaaatatgac gtatcataaa ccgaaatgtt 3595501 tcgattgaca caaaactttt caaatgaaaa aaacgccata ccaatagaat ttgttaaaaa 3595561 acgaatgcga taatgtgtta tgttcccaaa taatgtgata cctcatatag aaatagctaa 3595621 aaattcagag ccccatgccc atacattctc ctagcacatt aaacgaaaaa ataagacgat 3595681 agatccagtc catttctgca aaaacacgta tcaatttctg gaaaacatgg tataataatt 3595741 gtaacagaat gttcaaaaaa caatcacaaa acagacacaa ctcagttcct ctatttcatt 3595801 tttgtaaacg ttatcacaaa atgaaaggag acgggtatga tggacatgtt ttttgcttac 3595861 ttattggttg ccagcgcaac gcctctcttt atttggcttg ataacaaaaa agtcgcactc 3595921 tcagctattc cgccaatcat tttaatgtgg gtattcttct tcttttacgc aacagaaagc 3595981 ctttctccac ttggacacac tctcatgatt atcttgtttg ccgttaacgt cattgtcgct 3596041 catatcgccg catttatcat ttacggcctt ccgtatcttc gcagaaagcg aagcagctga 3596101 agacagcaaa aaaccctctt ccactgaaga gggttttttg tattattcgt tatggcctga 3596161 atgctctgag tgttcagcgc ctccaggagg atttccgtcc atatggtcac catggtgata 3596221 gtgagccgcg aaaatccaga tggatccaag tacgataacg atcgcgccaa agaatccgaa 3596281 cagcgtgttt ccgacttgga tcgtgccgtt ttcgctctct gtcatatgca tgaacatgag 3596341 aagctgcagc gccgcctgaa tgaaggcgaa gccgaagata atccaaagtt ttgctgatga 3596401 gctcaggtca gtatacactg caacccatag agccagcagg gtcaaaacga tagacaggat 3596461 aaaacctaca atgtgtttcc atggaaagtg actgtgttca gcagatttgt ttgccatttt 3596521 acagaccccc caatcccatg agatagacac ctgtaaagat gaaaatccat acaacatcta 3596581 agaagtgcca gtacaagctt gagataaaga ttttagatga agtttgcgga gttaagccgc 3596641 gtttcttcaa ctgaatcaga attcctgtga tccagaaaat cccgattgtt acgtgagttc 3596701 cgtgagttcc aagtaaaaca aagaatccag accagaacgc acttgtactg agagccgctc 3596761 cttcatgtac atagtgaaca aactcgttga tctcgcatcc gacgaagccg gcaccgagaa 3596821 gaagagtgat aattgtccaa atgactacgc cttttaaact tccgcggcgc atttcatgaa 3596881 cagcgatccc gcaggtaaag ctgctgatca gcagcaagaa cgtcataatc attaccagat 3596941 tgacttcaaa tagttcgtct ggcaagacac ctccagctgt tctgttttta agaacgaaga 3597001 aggttgcaaa tagtgttgag aacaacacaa tttctgcccc taaaaagatc caaaacccga 3597061 gaatattaag tctgccggtt tcagattgat attccatagg cgcgttagaa ttgccgtgtt 3597121 ctgcatgttc cataactcac gcctccttat tcggaaatct ttctttccgt ctcttttatt 3597181 tcatcaacac taatgtagta gccgttgtcg tattcgaatg aacgcagaac catgcagagc 3597241 aggactccga tcaatccgac tacgcccatc cagtaccatt caaagacaag tccaaagcct 3597301 gcgagaccga aggcaacaga cataaagaac ggtctgcctg agttgcttgg catatggatt 3597361 ttcttgaatt tgctttcagg gtataattca gttttttctt ctttcatatg caggaatgca 3597421 tcttgagatt tgacttcagg aagcaccgca aagttgtaat gcggcggaat cgcagaagaa 3597481 gtcgcccaat caagcgtacg tcccacaccc catgaatctc cgctgatttc acgagtagag 3597541 taacggaagc tgtagtagat gttatagcaa aggattaaga atcctacacc catcatgaaa 3597601 gctccgactg ttgagataaa gttcaatgtt gtccagccgt cattcggtcc gtatgtgtaa 3597661 atacggcgcg gcatgccttg aagccccaag aaatattgcg ggaagaaaca aatattgaac 3597721 ccgatcataa agatccagaa gaaccatttt ccgattcttt cgttcagctt gtggccgaac 3597781 atttttggat accagaaaat aaatccggcg aaacaagcaa atacagtacc cgcaatcagc 3597841 acatagtgga agtgagatac aaggaagtac gtattatggt attgataatc cgctgctgcc 3597901 atcgcaagca taacccctgt aaccccgccg ataacgaagt taggaatgaa cgcaagcgcc 3597961 cacagcatag gtgttgtaaa gctgattcgg cctttataca ttgtaaagag ccagttaaag 3598021 attttaaccc cggttgggat tgagattgcc attgtcgtaa ttgagaagaa tgagttaacg 3598081 gacgcactgt tccccattgt gaagaagtgg tgagtccaaa ctaagaaact caatacagag 3598141 atggcgataa tagaaccaac catcgctttg taaccaaaca attgttttct tgcaaagctt 3598201 gagatgattt ctgagaaaat accaaacgcc ggaagaataa cgatatatac ttcaggatgt 3598261 ccccaaatcc agaacaagtt agcccaaagc atcggcatac cgcctgcttc caatgtgaaa 3598321 aagtgagcgc cgaacaaacg atcaaatgat aaaagtgcta atgctactgt aagtacaggg 3598381 aacgcaaaca cgataataac cattgtgatc agtgttgtcc atgtgaacat cggcatacgc 3598441 attaatgtca tgccttttgt tctcattttt aagattgtta ccataaagtt gatccctgtc 3598501 atcagggtac cgataccggc aatctgaagt ccgaggaggt agtagttctc acccggccca 3598561 gggctcatgt cgttacttgc aagcggcata taactcgtcc agcctgcgtt cggagaacct 3598621 ccgataacga aagaaatatt gaaaagcatc gcccctacaa agaacgtcca gaagctcagg 3598681 ttgttcaagt aagggaacgc aacgtcgcgg gcaccgattt gaagaggcac aacaacgttg 3598741 ataagaccga ttaagaacgg catcgccatg aagatgatca tgattgtacc gtgagttgta 3598801 aaaatttcat tatagtggtt tgagtctaaa aaactgttat tcggaagcgc tagctgggca 3598861 cgcatcatca gaccgtcgac accgccacgg aataacataa ttacagcaga tataatatac 3598921 atgattccga gttttttatg gtcaacagta gttatccatt cagaccacag ccatttccac 3598981 tttttgaagt aagtcagaac aaaaataatg gcaatggttg aaagcgcaat ggaaacttgt 3599041 gcgcccagaa ttaatgggtc accagttacg aaaaattcgt cccatttgaa tttcatgcag 3599101 gcttcctcct ttcctgatca atatcattct tctgtatcat cagacttctt aaattcgttt 3599161 ttctttacgt tttcaaacgg atctgtttta gaatgcggtg aaacggcttg atagccaagg 3599221 cgtttgcgcg cctccatcgc gtactcagcg tcttgtccgt gatcaacgta tttcaagtga 3599281 gtagaagaga acgttaattc gtccacattt tcaggaagca tcaattcatc atacttctct 3599341 tttgtcagct taggagcctc gttctgagtc tttttcaccc agctgttaaa gtctttttct 3599401 gtgactgcat tcacatcaaa ctcttggtct gcaaaatgtt cacctgtgaa gttcgcgttg 3599461 cggccttcgt aagtacccac tttgtcagcc tgtaagtatt gatccatcag cattcctgcc 3599521 atcgcatatt tttgccctcc aagctgagga atccatagcg aagccattga atctgcagat 3599581 gagattttga acaagatcgg gcggtcgaca ggaatgttta agtagttgac cgtttcaata 3599641 tcctgttcag ggtagctaaa tacccatttc cagtctaccg aagtagcata aacaacaaga 3599701 ggctctttgt cttttgttgc ttcaggagct ttttctaacg aatatatcgt ctgtactgtt 3599761 ggcacagaaa gtgcaatgac gattaaaatt gggatcactg tccagactac ttctaaaaac 3599821 gtgttaccgt gaatttctgg gttataagat ccattatctt tgcctttacg gtcgcggtat 3599881 tttactaaaa taatggtaaa tagaacaaag acgaccccga cgataaacag cataaatccg 3599941 atagataaca ggattaaatc actttgctgt tcagctacag gtcctttcgg atctagtact 3600001 gaagcattgc tgcatccccc aaggacgaaa accacagtta acagcgctaa tacaagcaac 3600061 ggttttaatg ctctgaacaa gaagatcacc atccttccta ttgatgtaat aaatctgaag 3600121 tgcatacttc ctcaaaatct tttctctact ttgttatgct atcaaaaact tcacttatta 3600181 gctttatttt tttataaact tcatcccatt ttcgcttaaa tgtcataaaa tcgacaaaaa 3600241 ttgctccaac tttattcaca tctatcgctt aagatgaaaa gtttctagtt atttccgcat 3600301 ataaagtaaa gaaagatgat gaagaactaa ttctgacaaa ttaaggttta ccacaataaa 3600361 aaacttaggt caatcaaaaa tttcattttg ttaaactttc tagataggaa ttattttttc 3600421 ctcgtctagc atcttttcac acggttacca ttttaacgca tcaaatattg aaagaaaagg 3600481 cgcaatgaag agccaatatg ctctgaattg tccgtatttt tttatgagag catccagttg 3600541 tttatcttat acaaaaaaga ggaatgatat aagcaaataa ataaaaaata ggatgtgttg 3600601 catgatgagt tttcttattt cacttatcgt cgctattatt atcggatggc ttggaagcct 3600661 gtttgtaaaa ggagatatgc ccggaggaat tatcgggtct atgatcgcag gtcttatagg 3600721 cgcctggatc ggacacgggc tgcttggaac atgggggccg cacctagccg gatttgccat 3600781 tattccagcg gtaatcggcg cagccattgt tgtctttcta gtaagcctgt taaccagaaa 3600841 aagaggataa aagcagcagc acccgaagcg tcagcgcttt gggtgtttgt tttgccataa 3600901 aaatcgaaaa agcctcaacc ctagcggttg aggcttttga ctggtttggc gcccaactga 3600961 tcgatgaacc ttctgaaggc ctgttttccc tctgctgtct gcttaaatac accggcgtgt 3601021 tcaaggatgc gcgcgaatac atgtcccagc tcttctttta tgactagatc tacgttctct 3601081 tttgttatgg ttcttttttc catcgtccga agagcccact cactatgctt tgcagtgagc 3601141 ggattttgtt ctaaggctgt tttcggatca gcagaacata gcgccgctgc cgtttctttc 3601201 atttcctcct gtaagcggcc aggcaatatc gccaatccca tgacctcaat caggccgata 3601261 ttttcttttt taatatggtg gacttcttga tgaggatgaa atattcctaa tggatgctcc 3601321 tcatccgtcc ggttgttcct cagtacgata tcgagttcgt acaagtctcc cctgcgccgc 3601381 gcaatcggtg tgaccgtatt atggggcgta tcgcctgtat aggcggcaat gccggctttt 3601441 tcatcggaat acgtctgcca cgtgcggaag atatggtcag cagcttcggc gacatgaccc 3601501 ggttcgtctc cttggagcct gagcacagac atcggccact tcactaagcc cagcgacacg 3601561 ccgggataat catttaattc ataaacgtct tccgcttctg cacgtgccat tggaaaatca 3601621 tgcgcgccgc cttggaaatg atcatggctt aggatgctgc cgccgacaat cggcagatcc 3601681 gcgtttgaac cgataaaata atgcggatat tggccaagaa atgacagcag cctttcaaat 3601741 gtttttttgc tgatctccat cggttcatgt tcacctttta agacaatgca gtgctccgga 3601801 taatagacat atggcgagaa ttgcaggaac cattgttcgt cctcaaggat gaccggaatg 3601861 attctgtgat tttgccgggc tggatgattc acgcttccct cgaagccgac attttcttta 3601921 cacagcaaac acatcggata atttgtctgt tcctgctctt ttgcagccgc aatcgctttc 3601981 gggtcctttt caggctttga taggttaatg gtcatttcca gctcgccata ttcggtcggc 3602041 accgtccaat gaacattttt ggcgattctg tcagtccgta tataatagac atcctctgaa 3602101 tattgataga attcctttgt cgcctgtttt gggccgtata atgcttttgt ctcttcaaat 3602161 ttgcgaatga cctcggacgg ggcaggcaca aaacagccca tcagctttgc gctgagcagg 3602221 tcacggtacg tatctgtatc cgcttccatt cggccggttt cggcagccca tttatagatg 3602281 ggagctagca agtccggcag gctttgtgac tgcttgatgc tggtgctgga gttcggctcg 3602341 ggatgtgtga tgcccagcgc ttcataaaga cggtttctcg tatattcccg atcccagatc 3602401 gaaatcaatt ttcgttccag gccatactca agcagctgtt ccagatgttc aataatactc 3602461 atatgtcact ccccctttag ttctctcgct ccctctccga tatccgcgac ataaaagtcc 3602521 gctcggagcc ctgttttttc ttgatatctg tctccaacct tctgaataaa atcatcaacg 3602581 aactcatctt ttacaatgct gatggtgcag ccgccaaagc ctgctcccgt cattcttgat 3602641 ccaattacac cttcgtgatc ccatgccgca aacacaagct catcaagttc agggcatgtt 3602701 acttcatagt catccttcaa tgaaaggtgg gattccttca ttaactgccc gatttcatct 3602761 atattgttct ctttgaacat atgggccgtc ttaatagcac gatgattttc gtatacagcg 3602821 tgctttgccc ggcgtctgtt cgtttcattt tggatcaggc tggaatgcgc atcgaaatca 3602881 gaaggcttga tgtcgcccag tgcggcaata tcgaggcctt ttttcagatc aagcaatgca 3602941 tcattgcatt cttggcgtct cgtattatag ctggagtcag ccaatgtcct ttttttgttc 3603001 gtgttcgcga tgaccagcgc gaggcctgag acattgagtt tgctatattc atagtcaagc 3603061 gtgtcacagt tcagcagcat cgcatgatgt tttttcccca ttccaattgc aaattggtcc 3603121 ataattccgc aattgacgcc gataaaatgg ttttccgcat gctgcgccat tttcacaagc 3603181 tcaagcgcat ctacttcagg atgaaaataa ctttggagca cgacccccat cagcagttca 3603241 atagaagcgg aagacgacag tcccgccccg tttggaatat tccctgaaaa tacaatgtca 3603301 aagccatggg gaactgcata tcccctctgt tgaaattcat aaatcacgcc ttttgggtag 3603361 ttcgcccagt cgtcttcttt ttgatagcga atgtcgtcaa ggctgcattc cttgatgcct 3603421 gcgtttctaa agttatctga atacatccgg acaagcccgt cgtttctttc tgcaacagca 3603481 gcatatgtac ccattgtcag cgcgcacgga aagacatgcc cgccgttata gtctgtatgt 3603541 tctccaatca gattcactct tccaggtgcg aaaaaaaacc gtaacccctc tttttctccg 3603601 aatacacttg caaatatccc ctttagctct tcccgcatgt gcaatcacct ttctggtttt 3603661 tattttttat tccccttatt tcttcataga aaacggcaga tcatatgctg cagtcctctc 3603721 ataccccttc ttcttttgtt tttttaaaga cgagccattt gctcgcaaca tagttgacga 3603781 caacaatgac cgcgttgtcg agtattttgg ccaaggtttc atttgtattg aactggccga 3603841 caagaatgat catcatgcct aaatctatgc cgagagacag gacccgaacg ctgaaaaaag 3603901 cagtgagctc tttcagcagg ctctgcagat catgtgtttt ttgctgaaac acatataatt 3603961 tatttgttat gtaagcaaac agcacggaca aaatccaagc ggcaacagtg gcggctttgt 3604021 aatccacatt catgatctct accaatatat aaaagctggc gatattcaca atggttgtga 3604081 aaacccccat aatgatatac ataattattt ctctatactt cactgatgtt cctcgctttc 3604141 tgaaaaactt ttcaaaattc ttggcctctc gtgctctctg tctaaagtaa aaaataccga 3604201 gagtgcgtct aaaaagctgc ggaaggtggc tggctggccc aatacatatg attgtttgat 3604261 gattccgtcg aggactgcac atattatttt agccgtatat tcaggatcaa tacaggcgtc 3604321 aatcagcttt ctctccttca gccacttaat atataacaca ttttcttcca cccacaattc 3604381 gtacagccgg acataggcct tgcatttctt taagacttta tatgtcggca tgttcatggc 3604441 aaacgaggtg atgtcccacg acggcttatt tatgtaatag gaataaagca gttctgcagc 3604501 gtgttttgca gcctcgtcca atgtcagcga tttcactgac tcccgctcca tttgatcaag 3604561 ataccctata atgatctttt ttttcatctg acgtttttcg agaaggtaca gcagaaaatc 3604621 gtccttgctg acaaaatgaa cataaaatgc tcctttgctg tacccggcgg ctctgctgat 3604681 atcttctaca gaaaccggat catacgctcg gtcaatcaac aaattcacgc cagcgtctat 3604741 aaaactttca aatgttgctt ctcttttaat ttgaaatttg ttttttttca tatttttctc 3604801 ctggcggtaa tgattaccct tatcttacac cggatcaatc tttagcggta tttatttctt 3604861 taaacggtta tgctattcgg tttcccaggg gtcattttta ataggctaaa tgatttattt 3604921 tcatttacat actatccagt cagtatttaa ttgtttatta ttataaataa ggtccattgg 3604981 ttatattagt cattttttta gggaataggt aggtggtttt tccttcagtt tgtgaacacc 3605041 gagcaactat gtgtgaaatt tgttgtactc gcctccatca tcgcgctggc ttgtctttta 3605101 ttgcccgcat gttgcaggaa aacattttat acaattggag gttactatga aaactcatgt 3605161 taaaaaagat ttggacaaag gttggcatat gttaattcaa gaagctagat ccattggatt 3605221 aggcattcat gatgtgaggc agtttttaga atctgagaca gcatcaagaa agaaaaacca 3605281 caaaaaaacc gtccggcaag actagtccga acaggcggat ctatttacct ctggcttttc 3605341 tatcacctga tctgagtttt caccatatcc tctattcaaa agcaaatcgc tgcgctgagc 3605401 ttgaggacaa acggtgtgtc agctaactac gacagacagc cggtgatgcg atcacctctt 3605461 ggcacatgca ttgtcataaa gaggtgatgc gaacatgata accgtgctct ggtaaacagc 3605521 agctttgctg agaacaagct gcattcggtg aggttttgaa agcaaactcg tttatacacg 3605581 gccgagcttg aaaaccttcg cctgtcttta gaccactgtg ttcacctctt cacgacttcc 3605641 ttcttttttc atcctccagc tattgtacaa cgcataaatc ggactttcag tacataccta 3605701 ttggtgtacc tttttgctta cgtttagcga ataaaaggag gaaagccatg tacaaagctg 3605761 attataaaca gattgctgca acgccgtctt ttcaagcttt tttaaagcag aaacgcgctt 3605821 ttattgttcc ttctgcgatt ttcttttttg ttttttattt ttcactccct gttttgacat 3605881 cttatttcac ctttttgaat gcaccggcca ttggagctgt ttcatgggct tggctgttcg 3605941 ccatcgccca attcgctatg acctggatac tgagtactgt gtattcccgg agagccgccc 3606001 atttcgataa gtatgtaagc gctttaaaag aggatctgaa gggtgaacag acatgaatat 3606061 gactgctttt ttattatttt tggcgattgt tggcctgacg cttattatca cgtattttgc 3606121 cgcgaagcgg acgaaaacga cgagtgagtt ttatacggcg ggcggcgggc tcaccggcgt 3606181 tcagaatgga ctggcaattg ccggtgacta catgtctgcc gcctcgtttc tcgggattgc 3606241 cggaatgatt gcgttatatg gatttgatgg cttcttttac agcatcggtt ttctggtggc 3606301 ttatctcgtt gtcttgtaca tcgtggcgga gccgcttcgg aatcttggaa agtacacgat 3606361 ggcagacatg attgccgctc gctttaaaga aaagaaaatc cgcggtgtcg cggctctcaa 3606421 taccattgcc atctctactt tttatatgat cgcccagctc gtgggggcgg gcgcgctgat 3606481 caaactgctt ctagggctgg attataccgc ggctgtcctc atcgtcggag tgctgatgac 3606541 catttatgtc gtgtttggcg gcatgatcgc gacaagctgg gttcaaatta ttaaagctgt 3606601 tttgctgatg gccggcacac tcgtgatttc gattatcgtg ttttcgaaat tcggctttag 3606661 ccttaatacc atgtttgaac agatgaaaac ggctactccg cttggcgctg attttttgaa 3606721 ccccggaaat aaatacaagg tgccgcttga gaccttgtcg ttaaacttgg cactcgtgct 3606781 gggaaccgcc gggcttccgc atatattgat ccggttttat accgttaagg atgccaagac 3606841 ggcccgtaca tccgttgtgt cagcgacatg gattatcggt gtgttttaca ttatgacggt 3606901 atttctcggc tttggtgccg cggcatttgt cggttttgac gcgattacgg cggctgatca 3606961 agcgggaaat atggcggctc cgcttttagc aaaagcgctc ggaggagact ttctgttcgc 3607021 gtttgtatca gccatcgcct ttgccaccat tttggctgtc gtgacagggt tggtgctgtc 3607081 tgccgcctca gcatttgccc atgatattta cagccagatc atcagaaagg gagaagcaac 3607141 tgaaaaagaa caaatgaaag cggccagatg ggcttctgtc gccgtgtcag tgctctcgat 3607201 tctccttgcg atttttgcac aatccttaaa tgtggcgttc cttgttgcac tcgcgtttgc 3607261 ggtagccgcc agcgcaaacc ttccgctgat tgtgtttaca gtcttctgga aacgattcaa 3607321 tgcctcaggc gctttatggg gcagcctgac aggcctgatc agcgcgcttg tgctggtatc 3607381 gatgagccct agtgtgtggg acccggccgg aggtgctatt tttaccggtg atccgctcat 3607441 tccgctatct aatccaggaa ttatttccat cccgctcggc tttctcggcg cgtggctcgg 3607501 aacggtgctg tcgtctgata aaacaattga tgaagatacg tttgcagaaa ttcaggtgaa 3607561 ggcgcatact ggcgtccata tggaacagga ataaaaaaag ctctctttat cgagagcttt 3607621 ttccttactt tttcttctgc tcgtcagaaa tcgctttttc aaatacatcc ttgccggcag 3607681 cacccggaat tacagtgtca ccgataataa aggttggaac ggctgtgatg tcagcctctt 3607741 cataggcgtg cttcaaggct tggcgctgca cgtcctgata tgttcttgtt tccagtgctg 3607801 atttgaatga tgcaccgtct aatcccactt cctcggcgag cttcgtcaag atgtcaatat 3607861 cgccgatatt ttggtcctcc tggaaaaatg cctgaaagac acgggtgttg tattcatgtc 3607921 ctttattgta ttccttcgca aaatggaagc cttcaaacgc gaggtctgta tacggatggg 3607981 gcgagacgtt tggaaaattg atctcgactc ctaatttctc cgccattggc tgaattgatg 3608041 tctgccacat gtactgttta gaaggatcat tgaccggatc aagctgagga gatgggcttg 3608101 ggcgcagttc aaacggcatc cactcgactt caacatcctt tccttttatc gcttcttcaa 3608161 aagcggcttt tccaacaaaa caaaatgggc agacgtaatc tgaataaact ttaatgtgta 3608221 ctgtcatgat aatctccttt catactaaat tgattttaaa ctgtaacaat taaagttaca 3608281 actgtttttt aataaagaag ccgatttagg cttctttcag attgatgaca aaatcctaaa 3608341 aagttttagg attttgtcat cctttcagcg tgattgaaaa cccttgaagt ctaggaaagc 3608401 cgagcattgg agcggagcga atgctctaat tcgtgagcac caacgcacag gcttgacaac 3608461 gaatgcgagg gtttgtcgac acgctgaaag aagcctgtaa aggcttcttt tatgattcca 3608521 gcaaacgctg ggcaatatat tctccttttt tgcagccgcc tgggcatgcg tataaagcag 3608581 aaccgattgt ttgtgtatat tcgtttaacg catcctttgc tgaaagagcc ttcagcatcg 3608641 ggataaactg attgtcggga tttttttgaa aactgataaa caggagacct gcatccatat 3608701 agccggtttt cggatcaagt ccttctgtgt aagagaaagc tcttcgcaaa atttgtttcc 3608761 cagtagattt cgctagactg acgtgtgaat tagacggaat ttgattcagc ttcacgggat 3608821 ctgtttcctt tttctgccca aaaggcgccc ccgagctttt tctgcggccg aaggtatcct 3608881 cttggtcctt gagggaagag cggtcccata cctcaaggaa cattttgatt ttccgaaaag 3608941 ccatataggt gccgcccgtc atccagtcag gctcaccaga ctgaatccac acgatcgagt 3609001 tcatcaacgt gtcatccttc gtgctctggt tgcctgttcc atctttaaac ccgaagaggt 3609061 tgcgcggtgt ttcaccattt tttccaccgc ttaaaaagcc tttgttcaca aaacggacct 3609121 cacaagtgcc gaccgcttga tttagcaggt tacgcagcgc gtgaaacgcc acttgctcgt 3609181 cgtctgcaca cacttgaatg cagatgtccc cgcctccctg cttttcatcc aggttgtcat 3609241 tgggcatcgc tggaagagcg gctaggtgct tcggtttttt gcttttcagt ccgaagcggt 3609301 cctttccgtc tttttcaaaa aagccaggcc cgaatccgaa tgtgaccgtt aagttggaag 3609361 gggataaatc agcagactca cctgtatcct gcggcggcag atactgattt ctctgctccg 3609421 ctgacatttt cttgccagac gtcagcatct gtgtgagact tgtccagttt ctaaataacg 3609481 taatgatgtc gcttttgtct tttgctgtta catccagtgc agcaaaatag acatacgtct 3609541 gatgggcagt tgtgattccg gcctgatgct ttccgtaaaa cggaacaatc tgctcctcct 3609601 ctttttcatc ctttttcgat ggcttagccg cagtctgaac aagcggagcg agaccgccga 3609661 gaccgctggc accgatcgca acggctgccc ccgccatcgc tccccatttt aaaatgtccc 3609721 gtctgtgaat ttgttctggc tttttctgtt catcgctcat gatgttacaa aactcctttt 3609781 atagcacatt cgcaatcttc gacatggttt cagaaagagt cgtcagctta gtgctcagct 3609841 ctctgatttg cttttcactt aatttatcat aagacgtata ggactgatca tttgttttgt 3609901 attttgccat taaaacttca aattcgctga actccgtatc cagtttttcc gtcaagtcgg 3609961 agtgatcttt tacaagcgcg cttttcactg tttgataaac ggcttcggag ccttccacat 3610021 ttgccataag gtcaactaaa tcaattcgtg agtagcgctc ttcttctccc gtgattttcg 3610081 aaattccggc ttcgttcaga agctccatcg cgcctgcaac aatttgttca ggtgttaatt 3610141 tcagtgattg aattgaaccg tcaagctctt ttacatcctt gagaagctgg tcagctgttg 3610201 ccttttcccc ggaaatatct tgatccttcc aaatggcctt ctcaagctta tggaagcctg 3610261 tccatttgtc tccttcttca acatcgtttt ctcgtgcgtc aattttcgga tcaagatctc 3610321 cgaggctttc agcgatcggt tcgattcgct cgtaataaac acgcgctttc gcatataacg 3610381 ttttggactt ttcgatatcg ccggatttca cagcacccgt aaatgcttca gtcgctttga 3610441 caagctggtc actctgctct ttgacatagc ctttatactc atccgctgct tttgccagct 3610501 gatcgctagc ctttttgccg ctcttcttcg cttctgtcag gtcttctaag gatgctttca 3610561 atgactcgga ttctgtcttg atttttcctg catccggttt gtctttttgc gcttctgtgt 3610621 agattggctg aagatgcttt tcgatttctg tatattcgaa tggatagtcg ctgcgaatat 3610681 cgttttcaaa ggaaagccag tagctgttta actctttccc cttcttttca atctcttttt 3610741 ggtctccttt ttccactgag tcattcagct tagaaatgat ggtttccatt ttatttacgg 3610801 atgcggtgat ttctttagtg accccgcttt tttcagatga agctttttct ttggttgaag 3610861 atgtgtcatt ggctccgcag cctgcgcaca gcgcaaggat gcatccggct gatacagcga 3610921 tttttgtgaa attcattttg tcagttcctt tccgtttgta aaatgttttg ccgcttctga 3610981 aacaagcgca atcagtaaaa agagtaaaat caacatttgc ggaatcgtgc tgtacacaga 3611041 cggataaatt cctagcaccg atacagacgg cagccagctt tctgcatcag acggaagaat 3611101 gcccgccagt tgaaggctgt gaacgccggt tccgagaaat ttcacgcaca tatacaggac 3611161 aaccgccatt gatagaagaa aaaacggctt caatggaatg cgcattccga gcttgatcat 3611221 cagaacaccg acgatgacga gaacgataag ccctgcggca gttccgccga tcagttcagt 3611281 gagcgggagc ttcccgacaa gcccgatgaa aaagatgacc gtttcgagac cttctcttac 3611341 aactgccaga aatgcaatga gcgcaaagga aagcaggctt cgttttttta gtgcctgtga 3611401 cttctggata ttgatttttt ctctccattt atccattgag gcgtttctgt gcagccacac 3611461 cccgacatac aaaagcatga cagcggacag tacgccggta acgccgccaa gcaagaaatt 3611521 gttttctccg aatacactgg aggagaacag aaccgtgaca ccgatgccgg ctgctaagga 3611581 aacagccatg ccggcggacg ccccgcccca gatccatgtc gaggaacgcg taacccgcgc 3611641 tttttttgtc atggttaata gcgctccgat gacaaggagg gcctccattc cttcacgaac 3611701 cgggatcagc gccgcatccc accagctgta gctgcttgaa gcgatcggct cgagcaattg 3611761 aatcatttcg tcaatttgct ttgatacctt ttcaggatgg ctgccgatct ccgccttcat 3611821 cagcgccaga ttttcctccg atgtcgtata ggcttctttc gattgggaca cgacatctcc 3611881 ctcaacagcg agccaggatg taactaaatt gtcgattgcg gatgacgctt catccaattg 3611941 ttttttttct atgaactgtt ttgtgtcttt caagctttgt atataggctg ttaaggacgc 3612001 ccttgattga cctgaggatg tctttttcag cacgacagcc tgctgatagg tttctaaatg 3612061 agacgcaagc tcttcaagct gtgttttgag cttacgtgcg tcttgattga taaaagaaag 3612121 agaaatcatc gcgatattcg cgtccatttc actgtgagaa gaaaggtttt ctttcttaat 3612181 agaaggttct tcttttttcc acttcgcctt gaaggtgtca aacgtttgtt gtgccgaatc 3612241 catatccccg tcttttacgg atttgatcat ttgcttgttt aattgaatta atgcggcgat 3612301 cggatcatct tccgcatgtg ccgcagaacc gaaaaccatc aacaagctga atagaataag 3612361 tgccagcccc cgagccatca tgttcctcct ataattgaaa atgattatca ttgtataaca 3612421 taatcatagc cagttcctgt cctttgtcaa ttaaaatttg aaggtctgaa aaccttgatg 3612481 gacagcaaaa aagctgtcct tttacagaac agccctttga aggaaaatga acgattatct 3612541 tcctgtttta tacgtttgaa tttcctcacg aaacttgcgt gcagcactct caggatcctc 3612601 cgcctgactg atggcgctga tcatactgac gccatcggcc cccgcttgga taacaggtgc 3612661 ggcattatct attgtgattc cgccgatgcc gacaattgga atgctgatgc cttggcggcg 3612721 cactgcttcg ataagagata caccctgtac cgctctcgta tcttttttcg tttcagtcgg 3612781 atagatcggc ccaagcccga cataatccgc tccgtcttct tcggcttgct tcacctcaga 3612841 catcgtatgg gcagaaacgc cgagaatcat atcacctatg gcagctctta cctctttcgc 3612901 atttgcgtct tcctggccga tgtggatacc atcagctttc agattcagag ccaattccac 3612961 atcatcattg acaatgaacg gaacaccagc ttcacggcaa gctgcctgcg ctttttcagc 3613021 aaatttaatc cgagcctctc ctgtcagcgc atccccgcct ttttcacgga actggtacag 3613081 ggtggcaccg ccttttaacg ctttttgtac aactgtaaca ggatcggctt tcgtattgtt 3613141 tgaccccata atgaagtata cagataataa ctctttcatc atttcccgag aaatacgagt 3613201 catgagacag tcaccctttc tatagtcgcc cattcttgga cgtcttgttc agtaacagtt 3613261 gaaagcttgt tcagcaattc aatctgaaag cttccagggc ctttgtcagc cgtctgctgt 3613321 gcggcaagct gagcggcgac cccatacgaa gaaatggccg caatagcagc aaacaatgga 3613381 ttttcttcca cagcgcaaaa cgcaccgacg acggaagtca gcaggcaacc ggcgcctgtc 3613441 acttttgtca gcagcttgtg gccgttatga agggtgtata catgtgacgt gtcggctatg 3613501 acatcaactt caccagttat cgcaatgacc gtgtttagct tttgtgccgc ctgctgagcc 3613561 agccggatga tgtcgcctcc accttcaccc gcatcaacac ctttgatcag ccaatcggtc 3613621 acgccgacgg tatgggcaat ttccgccgca tttcctctga ttgcagcaag gcgcacctca 3613681 cgaatgatgt cacgtgccga ttcagtgcgg aacggtgttg ctccggcacc gacaggatca 3613741 agaatgacgg gaacgccatg ttcattagct gattttcccg cgatgatcat cgcttcgact 3613801 gactccttgc tcagtgttcc gatatttaaa acgagtgcac ccgcaatttt cgccatatcg 3613861 gcgacctctt cttttgcgta cgccataacg ggcgatgcgc cgagcgcgag caggccgttt 3613921 gctgtgaaat tcgttacgac attgttggtt atgctatgca ccagtgggct atgccggcgg 3613981 acagccgtaa gacattttgc tgctgattgt gcatccatat ttgcatcatc ctttactatc 3614041 ttttttcggg tcccataaat acgatttcgt atgttcgagc caagctctgg cggcaaacga 3614101 caagtacctg tcctttctcc aaataatggc gaggtgccaa gggatgaccg gatcgacaag 3614161 cggaatgact ttcacttttt ccgggtcaag gccgcggcag atccgttccg gcaaaagccc 3614221 gatcccaagg ttggcggata ccatctcact aataaaatcc cattgtgatg tttcataaat 3614281 gatatggggc cggaacccag ccttgataca ttccgtcata attcggttgt gcaggacaaa 3614341 atcctctctg aagaaaataa aaggctcgtc cttcaactca cgcagctgac attctttctc 3614401 atcagccagc cggtgggaag ggtgaacgac aagcattaag gtttctttta cgattgtaaa 3614461 cgaatgaaag atatcttcgt ttgcgggaag gaccacaacg ccgatatcaa gagagccgtc 3614521 cccgacacct tcttggactt ttatagaacc gtcttcgact agctgaaagg tgacattcgg 3614581 atagttttca cggaaatcgc cgagcactct ggggaaaaac cccgatccga tcatcggcgg 3614641 cagtccaatc cgtacgtgcc ctttcttgac ttccataata tcatttaatt ctgacgtcag 3614701 gttttgaaat gatttaatga tttcctgcgc ctgcacatac atgctatgac cggcatcagt 3614761 cagttccacc tgcctgccgt ttcggtaaaa cagttcaatt ccgagctctt cttctaaatt 3614821 tttgatcatt tttgatatcg tcggctgaga aacataaagg gattgggaag ccttcgtaaa 3614881 actttttaaa cgggcgactt ccaagaaata tgttaaatgg cggatatcca tgcgcttcac 3614941 cctttctata gacaaaagga atacttctta ttcttaatat atattttacc tatagagaga 3615001 ccttatgtac aataagtata taagggaggc atcaatatga aaaaactgtt gctaaccgtt 3615061 attcaaatcg ctctgttatt tatatttgct cggctgatta attgggtgac agcccttctt 3615121 catataaata ttcccggcag tataataggg attgtgattc ttttcacatt attgcacttt 3615181 aacattatca agcttgaatg gatcgagctt ggtgcagcgt ggcttctcgg ggagctgctt 3615241 ttatttttta tcccgtctgc cgtcggagtg attgaatacg gagacattat gtcgaaattt 3615301 ggtgtcagca ttctgcttgt tgtcatcatc agcacgtttg tcgtgatggt gtctacagga 3615361 acgcttacac aactcatcgc aaagagaaag gagaaaaagc atacgtgttc atcggaattg 3615421 taagtttgtt tttaacggtt ttggtgtatt taggagcaaa aaaggtatat caacgctttc 3615481 cgcgtgttta tacgtcgccg ctattggtga cgcccgctgt attagtcggt ctgctgctgc 3615541 tggtgaatgt cccgtacgag tcctataatc tcggcggcgg attgctgacc gatatgctac 3615601 agccggccac cgtggcattc gcgatcccgt tatataaata tttccctgtt ttaaagaaat 3615661 acgcagtgga aattattttg aatgtggccg tcggttcatg catcgcgatt atttctaccg 3615721 ctcttattgc gaaatggctt cacctcggca ccggcttaat tgacagcctc gtcccaagat 3615781 cagtgacaac gccgatcgcg atgaacgtat ctgaaatgat cggcggtatg cctgccgtca 3615841 cagccgtgtt tgtgatttta accgctttgc tcggcacagt gatcggcccg atggtcatcc 3615901 gttatttccg cattgataac gaaattgcgc ggggcgtgct gcttggcaca agcgcgcacg 3615961 gagcgggaac gtcaaaggca tttgagctca gctctgtgtc cggcacgatt tccagcgtgt 3616021 cgatgatctt agctgcgatt atgacgcttt gcgcggcgcc gtttttgctt tcatttatgt 3616081 aaaaaactgt cctctcgagg gcagtttttt ttatgtgctt ccccttattg aaaagctggc 3616141 gaattccaat ataatgtatt tgtggatacc aaaggaggca ccctgatgca caacttgcag 3616201 gtgaggcggc attatgccgc gttaaaagga ttttatttgt ttgcttttct cggtacgggc 3616261 agcataattc ccttactcag tatgtattta acgaaggaac agcatttaag cggatcacag 3616321 gtcggcttga tcatgtcact gggcccgatt gtgatgattt tctttcagcc gttttggggc 3616381 atgctgagcg actatacgca aaaaacgaaa ggcctgctgg cggtttgcac atcaatcaca 3616441 ggcatcattg gattagccta tattgcattt gacagtttcc ctctgtttat tttgattgcg 3616501 gcctgttttg cagcctttca aagcacgatt attccacttt cggacagcat ttcactaagg 3616561 tacacacaag aaacaaacgg caactacggc ggaatccgcc tgtttggttc tctcggcttc 3616621 ggtgtcgcgg tgtttgccat gggacaggtg acgaaccagc tgtaccccat tcacgtgatc 3616681 tttatctttg gctgtgcctt tctgtgcatt gctgccatat tggcttcaca agtgcccggc 3616741 cagcagaaaa caacaaaggt caatatccgc aaaggattcc gggagcttat cagcaacaaa 3616801 actttcctca tctttatgat catcaccttt acgacatttg ctccaaactt agcgaacaat 3616861 acgtatttca gtctttttct ggacaaaagc ggcgcgtcac tttccgctat cggcatttta 3616921 tttttcatcg gtgtcatttc agaaattcca tttatgagat tcgcccaaac atttatagat 3616981 aaaatggggc tgctcaacgt cattatgctg tcaggcggag tctcattatt caggtgggcg 3617041 ctctatttca cggcgccttc actatggatc atttatgcga cggtctttct tcagggagtg 3617101 gccatcggtt tatttatccc ggcggcgctt caatatgtga aaaagattac cccaagacac 3617161 gttgaagcga cggcgctgac catgtacgcc gccattggca acgggttcgg caactggttc 3617221 tgcacatttg caggcgggta catttttgac tacgtgtcga tcttcgcagt ctacttgctt 3617281 tttggcattc tgagcatagc aggctttggc ctgacattat atttaatgaa ggctgaaaaa 3617341 aacaaacata cacttcatca gccggctgtt acttttaaac cataatgact ataatgaaca 3617401 aaagaaagga tgtgcgttat gaacgggcaa gagcgaaaca gcatttcgaa agggttgcag 3617461 gttgatattg tattgaaagc agatcaaaaa acaggaaaac tgacgagagg gacagtgaag 3617521 gatattttga cgaaatcaaa ctttcatccg catggcatta aagtccgtct tgaagatggc 3617581 cgcatcggcc gcgaccagca gatcgtttct acataaaaaa aagctgcccc tgaacagggc 3617641 agctttttca tttatttttt ctgcagaagg accactttca ggtagttgcc ttccggaaat 3617701 gccgaaatcg ttttgaaatc ctccggcagc gtaaattcct caatgatcgt gtagcgttca 3617761 tttgtttctt taaaggcggc atcaataaag cctttgaact tcttcatgcc aaaggcgctg 3617821 ctgtttgtag aggcaacaat gacacccttg tcagcagtga tggcgatcgt ttccttcagc 3617881 aggtttttat aatccttggc cgcgctgaag gtgcgttttt ttgtgcgcgc aaaggaaggc 3617941 ggatctagaa taatcagatc aaagcgcaaa tccttttttg cagcatatga aaaatagtta 3618001 aaaacgtcca tcactttaat gtcgtgcgct tcgtaatcca gcttgttcac gctgaattgc 3618061 tcgatcgttt tggcaagact tcgatttgcc acgtcgacgc ttgttgtttt ctccgctccg 3618121 ccaagcgccg ccgccacgga gaatgcaccc gtataagaaa acgtatttaa aacggttttc 3618181 ccttttgcat agcggtctct gatcgccttg cgcacatgtc tctgatccaa aaagatgccc 3618241 gtcatggcgc cttcattcag atccaccgcg tattgaatgc cattctcttg gatgatgatc 3618301 gggaactcgc cccttctccc tttcacgaag tcatcatctt caacgtattg tccagccgtg 3618361 tcgaagcgtt tcttctcgta aatcgcttta taatcaagat ccatctcatc caatgcggaa 3618421 atcagcatgt ctttaaaggt gtaaattccc ttgctgtacc attgaatcag caggtagccg 3618481 tcataatagt cgatggtgac gccgccgaca ccgtcaccct caccgttgaa caggcggaaa 3618541 gctgttgtat cttgagcctc aaatagtttg gcgcgcgctt gggccgcttt tgttaatttg 3618601 ctgagaaaaa atgcttggtc aatctgttca tgtttattgc gggtaagcgt ccagccaacc 3618661 cctttgtttt gcaggccgta atagccccgc gcgagaaact cgccgccgct ctcagacacg 3618721 atatcaacga ggtctccttc tttcatgtgc cccgcactcc ctgcgagagc ttctttttca 3618781 ataaggggat agcctttttt tattttggca gcgtgtgctt tttttagggt gagtagcttc 3618841 atatatgtcg tcctctttcc gtttgctttc tcttatggta ccacaaaacg ccaagatgtc 3618901 tgcattgaca gaaaggaaag gtttttctac gatagacaaa aagagttacg aggaggagca 3618961 gcatggcaaa acgaattgac catacaggca tcatggtaag agatattaac gcgtccatca 3619021 cattttatga agaggtacta ggcatgaaat tgaaggatcg catcactcac acgaacggtg 3619081 taatcgagct tgcttttctt ggctttgaag acggcccgga aacagaaatt gaactgattc 3619141 aaggctacag cagcgagctt cccgctgaag gaaaagtgca ccacattgcc ctgctgacgg 3619201 atgacatcgc ggctgaatat acaaaagcgg aaaaaatgaa cgcaaaattt atcgacgagg 3619261 agatcacaac acttccaaac ggataccgtt atttctatat cgaaggccct gacggtgagt 3619321 ggattgagtt ctttcagcgg taaaaataaa gaacgtacat tttgtgatgt acgttctttt 3619381 ttatctatac caactgatat acgttgactc atcgcaaatc atagcttccc agcccatacg 3619441 ctcaaccaat tcatggatgt ttttatcttt ggctaaaaag acattaatga atgagtcata 3619501 tacactcata aacacaaaat ccattttctc atcagttaaa acgagctctg ttgcggcttc 3619561 atcaagaacc gtccgcaagt tggcttcagt tatgtccaaa acgccgcggt tttccacaat 3619621 cggttctgcg taataaaacc gattggatcc gttcgcacct aataccttta ccaaactcgg 3619681 aatatgaaaa tttgaaatat gatcctcact gggataatag aggtctccat ttatgttttc 3619741 atgtaacacc tcagccaaat cctctctcgc gaactcgtcc cttaaagcgc ctatcgacgt 3619801 cattaaagcc agcgccagct cagcatgtgt ttgaaagccg caagaagaca taaccttctt 3619861 ccaggaaaca gccttgccta ttcctcttat ttcattatcg tttggataaa tatgttcata 3619921 atcatttttt ctttttgcat tctcccatcc ttcaggcatt tggataaaag gagaaaagat 3619981 aagagcagca gatgagtatt caactggtac ttgttgtaag attggtgatt cgtcatctaa 3620041 ccatatataa tctagcatgc gcacctcctt tacatattct aacattcctt tcgtttgaaa 3620101 gagatgatca gccctatgac aggctgatca tctatcacat cacattttta tccccagatt 3620161 caaccgcact ctcttcccgc catttttgat gatcccatat tctgaaaaac ggatagtaga 3620221 tagcacaggt gatcagcaga tttaccagct gcataactgc gcccgacacc tttccgcctg 3620281 tcgccaggta acctgatatg agcggcggca tcgtccatgg caccgcgatt ccggccggtc 3620341 ttgccaccag cccggtgctc atgccgatat aagtcgcggt aatcgtgagg agcggtgcga 3620401 tgataaatgg gacaataagg aggggattca tgacaatcgg catgccgaaa atgatcggct 3620461 cgttgatatt aaatagcgca gggccgattc ctaatcgtcc aagctgcttc atttgtttgc 3620521 tgcgggagcg cacaagcatc gtcaggacaa gcgccagcgt cgccccgctt ccgccgacat 3620581 tgatccaaat ttgaaaaaac tgagtcgtaa aaatactcgg cagcgcctcg cctgcttgga 3620641 aggcgagacg gttggcatcc atcgcgccgt accaaatcgg cgccatgatt ccgccaatga 3620701 tggaagcccc gtgaatcccg cacgaccaaa gcagcatctg cacaaattca gcgatcaggc 3620761 ttccgccgag actgccgcca aggatggaaa gcggtgtgcc aagcaggtct cctacgacat 3620821 tgtgcagact ctgaaaaggt gtcatttcaa tcagaagacg cgccagccat acgagaagca 3620881 caatgataaa gccgggaatc agcgcgacaa atgatttgct taccgcaggc ggcacaccgt 3620941 ctggcatttt gaagacgata tttttttgaa taatgtaccg atagatttcg gttgaaaaca 3621001 aggcgatcag catggcgaca aataagccct tgctgccgag cagcgtgatc gggattccgc 3621061 cccctaccat gatggactcc gttgagccat gcggtgtaaa cggcacctca aacggtgttg 3621121 ccagcagaaa tgcggcaatt gaaatcgctc cggcagaaag ggcatcgaca ccatagcttt 3621181 ctgccagccg ataggcgatc ccaaaagcgg caatcatcgc cataatatca aacgaagcgt 3621241 taacaggata tccgagctta tcggcccact cgttcccaaa cacactcgcc atgaaatcag 3621301 cataccccgg aatcggcaag ctcgttaaaa tcaagaagac agacccgata ataatcagcg 3621361 gcatggtcag gataattccg tcacgcaaag cgctgagatg ccgctgcccg gcaattttcc 3621421 cggcgacagg cattattttt tcctccatca cccgagtgaa tgtgctcatc ttaaaaaccc 3621481 ccttttctca ttgctttgtg aacaacctcc gcaatgtttt ctttatctta ttttgaaaac 3621541 gcttacaaat tcatttggaa aatttcctct tcatgcggaa aaaatctgca ttttgctaaa 3621601 caaccctgcc catgaaaaat tttttccttc ttactattaa tctctctttt tttctccgat 3621661 atatatatca aacatcatag aaaaaggaga tgaatcatga aaaacatgtc ttgcaaactt 3621721 gttgtatcag tcactctgtt tttcagtttt ctcaccatag gccctctcgc tcatgcgcaa 3621781 aacagcagcg agaaagaggt tattgtggtt tataaaaaca aggccggaaa ggaaaccatc 3621841 ctggacagtg atgctgatgt tgaacagcag tataagcatc ttcccgcggt agcggtcaca 3621901 gcagaccagg agacagtaaa agaattaaag caggatcctg atattttgta tgtagaaaac 3621961 aacgtatcat ttaccgcagc agacagcacg gatttcaaag tgctgtcaga cggcactgac 3622021 acctctgaca actttgagca atggaacctt gagcccattc aggtgaaaca ggcttggaag 3622081 gcaggactga caggaaaaaa tatcaaaatt gccgtcattg acagcgggat ctccccccac 3622141 gatgacctgt cgattgccgg cgggtattca gctgtcagtt atacctcttc ttacaaagat 3622201 gataacggcc acggaacaca tgtcgcaggg attatcggag ccaagcataa cggctacgga 3622261 attgacggca tcgcaccgga agcacaaata tacgcggtta aagcgcttga tcagaacggc 3622321 tcgggggatc ttcaaagtct tctccaagga attgactggt cgatcgcaaa caggatggac 3622381 atcgtcaata tgagccttgg cacgacgtca gacagcaaaa tccttcatga cgccgtgaac 3622441 aaagcatatg aacaaggtgt tctgcttgtt gccgcaagcg gtaacgacgg aaacggcaag 3622501 ccagtgaatt atccggcggc atacagcagt gtcgttgcgg tttcagcaac aaacgaaaag 3622561 aatcagcttg cctccttttc aacaactgga gatgaagttg aattttcagc accggggaca 3622621 aacatcacaa gcacttactt aaaccagtat tatgcaacgg gaagcggaac atcccaagcg 3622681 acaccgcacg ccgctgccat gtttgccttg ttaaaacagc gtgatcctgc cgagacaaac 3622741 gtccagcttc gcgaggaaat gcggaaaaac atcgttgatc ttggtaccgc aggccgcgat 3622801 cagcaatttg gctacggctt aatccagtat aaagcacagg caacagattc agcgtacgcg 3622861 gcagcagagc aagcggtgaa aaaagcggaa caaacaaaag cacaaatcga tatcaacaaa 3622921 gcgcgagaac tcatcagcca gctgccgaac tccgacgcca aaactgccct gcacaaaaga 3622981 ctggataaag tacagtcata cagaaatgta aaagatgcga aagacaaagt cgcaaaggca 3623041 gaaaaatata aaacacagca aaccgttgac acagcacaaa ctgccatcaa caagctgcca 3623101 aacggaacag acaaaaagaa ccttcaaaaa cgcttagacc aagtaaaacg atacatcgcg 3623161 tcaaagcaag cgaaagacaa agttgcgaaa gcggaaaaaa gcaaaaagaa aacagatgtg 3623221 gacagcgcac aatcagcaat tggcaagctg cctgcaagtt cagaaaaaac gtccctgcag 3623281 aaacgcctta acaaagtgaa gagcaccaat ttgaagacgg cacagcaatc cgtatctgcg 3623341 gctgaaaaga aatcaactga tgcaaatgcg gcaaaagcac aatcagccgt caatcagctt 3623401 caagcaggca aggacaaaac ggcattgcaa aaacggttag acaaagtgaa gaaaaaggtg 3623461 gcggcggctg aagcaaaaaa agtggaaact gcaaaggcaa aagtgaagaa agcggaaaaa 3623521 gacaaaacaa agaaatcaaa gacatccgct cagtctgcag tgaatcaatt aaaagcatcc 3623581 aatgaaaaaa caaagctgca aaaacggctg aacgccgtca aaccgaaaaa gtaaccaaaa 3623641 acctttaaga tttgcattcc aagtcttaaa ggtttttttc attctaagaa caccacacac 3623701 aacctttttc ccatccattg tacaggcttt tcatactatt gctatacagc catgaacagc 3623761 ataaaatgaa cgttattaca gttatcacca catatggcgg gattgtgact gggcaggcag 3623821 gcaagaccca atgatgcaaa gggagtatta atgcctaaaa aacagggcat tttaactctt 3623881 cttttcgtgt tgggctcata acggcgcctt ggacaacccc ctattctcat gctccgtcgt 3623941 cgacgcgggc atttttgtca ttttcagccg gtatttctca cttttttcat tttgattgtc 3624001 aacttttcat ttgatacgat gaacaagccg acttttcttc agcaaaggag gttttaattg 3624061 cttgcataaa gagattgcaa aagaattact gctgctcgca ggaggaaaaa acaatattat 3624121 cagcatcagc cattgtacga cccgtcttcg ttttgatgta aaggacgaga cgaaaattga 3624181 tatacatgcc attgagaacc tgcaaggtgt gcagggcacc tttttccgct atgggctttt 3624241 ccagattatc ttcggagcag gcgtcgtcaa caaaatatat aaagaagtcg ttcatgtatg 3624301 ggagaccgcg ccttctgaag agcctgtcca ccagaaaaaa gccagccgga agctgaaccc 3624361 tgccgcagct tttgcgaaaa cactgtccga tatttttgtg ccgattattc cggcaataac 3624421 agcaagcggc ctgctcatgg ggctgatcgg catgattaag gtgtttcatt ggttcgctgc 3624481 cggcagccca tggattaaaa tgctcgacct cgtgtccagc acagccttta ttttactgcc 3624541 gattttagtc ggcttcagtg ctgcacggca atttggcagc aacccatacc taggggcagt 3624601 gattgcaggg cttttgacgc atcctgatct gctggacccg tctatgctcg gcagcaaaac 3624661 cccgtcttct ttagacatat gggggcttca tatcccaatg atgggctatc agggttccat 3624721 gataccgatt cttctttccg tttttgtcat gagcaaaatt gagaagctat taaaatcgat 3624781 tgtgccgaag tcgcttgatg tcgtgatcat tccctttatt acggtcatgg tgacagggtg 3624841 cctcgcgctg attgtgatga atcccgccgc gtccatcatc ggccagatca tgacacaatc 3624901 gatcgtctat atttatgatc acgccggcat tgctgccgga gctcttttcg gcggcatcta 3624961 ctccaccatc gtcctatctg gattgcatca tagcttttat gcaattgagg caacgctgct 3625021 tgctaatccg catgtcggtg tcaacttttt agtgccgata tggtcgatgg cgaatgtggc 3625081 ccaaggcgga gcggggcttg cggtattcct caaaacgaaa caatcaagcc tgaagaaaat 3625141 tgcgctcccc gcttctctga ccgcgttttt aggcattgtt gagccgattg tattcggggt 3625201 aaatctcaaa ttgatccgtc cctttatcgg agcagccatc ggcggtgcta ttggcggagc 3625261 atacgtggtt gcggtacaag ttgtggcaaa ttcctacgga ctgacaggca ttccgatgat 3625321 ttcaatcgtg ctgccgtttg gcgccgctaa ttttgttcat tatatgatcg gtttcttgat 3625381 cgcagccgtc tctgctttta tagctacatt gtttctcggg tttaaagaag agacagaata 3625441 actggattta ttcgatttca ttcataaaac gggggatgaa aggacaaaaa agctatgaaa 3625501 attaaaagaa tcttaaatca taatgctatc gtcgtaaagg atcaaaatga agagaagatt 3625561 ctcttgggtg caggaattgc gtttaacaaa aagaagaatg atattgtcga tccgtcaaaa 3625621 atagaaaaaa cctttatcag aaaagataca cctgactata agcagttcga agagatttta 3625681 gaaacattgc ctgaagacca cattcagatt tctgagcaaa ttatctctca tgccgaaaaa 3625741 gagctgaaca tcaaaatcaa cgagcgcatt catgtcgctt tttcagacca tctttctttt 3625801 gcaattgaac gcctgagcaa tgggatggtt atcaaaaatc cgctgctgaa tgaaatcaaa 3625861 gtcctttatc caaaggagtt ccagatcggc ttatgggcca gagcactgat taaagataaa 3625921 ctggggattc acattcctga tgatgaaatc ggcaatatcg ccatgcatat ccacacagca 3625981 agaaacaatg ccggcgatat gacacaaacg cttgatatta caacaatgat ccgtgatatt 3626041 atcgagatta tcgaaattca actgtctatt aatatcgttg aagataccat ctcttatgaa 3626101 aggctcgtga cccatctccg ctttgccatt cagcatatca aagcaggcga atccatttac 3626161 gagctggacg cagaaatgat tgacatcatt aaagagaagt ttaaggatgc cttcctgtgt 3626221 gccctaagca tcggcacctt tgtgaagaag gaatacggct ttgagtttcc tgaaaaagaa 3626281 ttgtgctaca tcgccatgca tattcagcgg ttctaccaac ggtcagtcgc acgctgagac 3626341 aaacaaaaaa cgcttttgat catctcaaaa gcgttttttt atctgattta ttggttgatc 3626401 gccggattcc caatcgtatt ccacttcgta taggacatgt aatggaaata ctcatcgcga 3626461 tacggatgtt ttgtattgga gttccaaggc ttttctccgc cgcagaagtg cacgattgcc 3626521 gggttttctc ttgtttcatt atattgcttc cgccctaaca gagtcgatgg ggttttcagc 3626581 tttaacatga tataggtttg agcgttccag cgcggatgaa gttcatacca ctgatcatac 3626641 aagatcgcat tcagtgcatc ttggtcatgc agcacaagaa agtcttcgtc tgggtgttca 3626701 ttgataaagt tgatgacttt ttctgtgatg ttttgctttc tccaagactc aaaatcaata 3626761 atcatgatac ctgagttaaa atacttccct gtatcagtga cgttcatttc tttcaggcgt 3626821 tcatgctgcc ccgcatcctc aacagcggct acggtgtatg gcgcaatgtc taagtcccat 3626881 agcttagaaa tatcctctag gacaagcgca tcacaatcga tgtaaatcat tcgtttgatg 3626941 ctttcatcct taattaagtc gggaatcgaa atgcggtaat acgcggcttt tgtaatatgg 3627001 ctgctctcaa ccgcatgttc atacatgttg gtatccactt ctaaaaactc aatcggcact 3627061 ccgaatttca aagtggtttc ttccagtctt tttttgttat caggcttaat tccgccatca 3627121 atgacgtata attttacctc tctctcctga tccatgttag tcaataaaga aacgaacatc 3627181 ccacctaaat gacgagcata attatcatct gcgcatgata cgatatgcat gatttcatct 3627241 ttcctcaatg gtattcatct ccctttttgt tgtacaagtt acataccctt tttcaaaaaa 3627301 ataaacacgt tctccgacat ttttttaaac agaatgtgtg atacaacaaa aaaggtgtca 3627361 ttttttgaag atgcgataaa gccaataaag aatgaaaaag cttgcgattg tgatggcttc 3627421 agccgagacg atataccacg gccatggccc gagaacatct aagagagagg aaccgcccgg 3627481 ttttttcgtc aaatacatat aattcgcgcc aagccagcga tcaatcagaa aaatacagac 3627541 gccgtacaca ttaacaagca ggactgtcac ccataacgag cgctggccca ttctgtaggt 3627601 gccaatcaca gccatcagca gacaggataa aaacacagac ccgtgagaaa taaaaaagag 3627661 gatatatcgg atatgcggaa atgaaaacat accgaggtca ggagtggcaa gagcctgaat 3627721 cgaactgccg atgccgacaa aaaacaaaaa cacaaacagc tttctgcttt ttgtcactaa 3627781 cataatagct gacaaataca ccgacaggtc actaagctgg agaggcaatg aagtgcgcac 3627841 cgaccacctg tccgtggcga ccatccatat ttgatagccg atttgcgaac caagcaaaag 3627901 aaacacaaac agagaacgca aaaaccggct ggccctcggc tgcttgacct catcttggaa 3627961 caaaaacaac agaatggcca aaagggagat aatcgctaac gtcactacat gctctgtcga 3628021 aaacagatga aacggatcat gcttatagtc ggattgaaca tatttttgca aaactgcacc 3628081 cccgttttcg ggtttttgtt tattttggcg ttgtttgggc tttttttatt caaccgatat 3628141 atgggcttga agttcacacc agactctgtt aaaattcgtt tcatagctaa tgattctgat 3628201 aatttaaggc aggcctaaaa aatggaacgt tcacatcaac atcagcagct tcggaaggaa 3628261 gaacacgata cactttctaa gctcaaacaa atgcccgtcg agtcactcaa cctggaagcc 3628321 atttcgatcg ctacgaatct gtatcggtct gcacaaaggc tccgtgtcaa aatggagact 3628381 gaggttcttt ctacctataa cctttcttgg accgctttct ccattcttta tgatctatgg 3628441 gtatggggag cgctcgaaac gagaaaaatc gctgagctgt cagggatatc tacagctaca 3628501 gcaagcaacg tgatcaaaac gctcgaaaaa aagagttttt gccgtaaaag catcgacaca 3628561 agagatcggc gactcgtgtt tgtctcaatc accgattccg gcaaacaagc gatcgaagaa 3628621 ctctacccgg agtttcacaa aggggaaaca gagctcattg cgggaatgac gaaggacgaa 3628681 cagaaaatat tgacagggct gcttagaaag gtagctgaca atcttcatac aacataagct 3628741 ttgacgggaa tccagtagcg gtttgtctcc ctgtttcaga gagccggcgg taggtgcgag 3628801 ccggcgcaca ggcaaacgtg aattacctcc ccaagctttc tttgtgaacc ttagtagcaa 3628861 agaacgggaa accgttattc gaatgagcgg aagacaatgt cttcaaccag ggtggtaccg 3628921 cgtgcattga gccacgtccc ttattgggat gggctctttt ttgtgtttgt aaaaaaggag 3628981 gaaaaatgat gagaacattt gagcagctca cagcgtcaca acaaaaagag gtagaaagac 3629041 agcttcagct atacatgaca ggcgcccacg aagtcatacc gccggaggaa ttaaaggcaa 3629101 agctcgtgaa atcaatttcc acgggcacgc cgcttaaaat taagctcgga ttagatccgt 3629161 ctgcaccgga tgtacatttg ggccatacgg ttgtgttaaa taagcttcgc caatttcaag 3629221 aaaacggcca cattgtccag ctgttaattg gggatttcac aggaaaaatt ggtgatccga 3629281 ccggaaaatc ggcagccaga aagcaactga ctgatgaaga agttcagcac aatgccaaaa 3629341 cctactttga gcaattcgga aaagtgcttg atccagaaaa agtcgagctt cactataact 3629401 caaaatggct gaaaacattg aatctagaag atgtcattga attagcaggg aaaataacgg 3629461 tagcccgcct gatggagcgc gacgactttg aagaacgcat cgccatgcaa aaaccaatct 3629521 cactgcatga attcttttac ccattgatgc agggctatga ttctgtcgtt ctcgaaagtg 3629581 atattgaatt aggcggaacg gatcagcatt tcaatgtcct catgggacgg catttccaag 3629641 aacgatacaa caaagaaaaa caagtcgtca tccttatgcc gctcttggaa ggcttggatg 3629701 gcgtcgagaa aatgtcgaag tcgaaacaca actacattgg cattaacgaa catccaaacg 3629761 acatgtacgg aaaaacgatg tcactgcccg acagcctgat gaaaaagtac atccacttgg 3629821 cgacagactt agagcttgaa gagaaaaaac agctcgtaaa agacttagaa accggcgccg 3629881 ttcatccgcg tgatgccaaa atgcttttag ccagaacaat cgtccgaatg tatcacggag 3629941 agaaagcagc agaagctgcc gaacactcgt ttaaaacagt ctttcaggaa aacagcctgc 3630001 cggaagatat accggccgta aactggaaag gcgaaaaaac gatagcgatg attgatctgc 3630061 tcgtcaagct aaagctcctc tcttcgaaga gcgaggcgcg ccgcatgatt caaaacggag 3630121 gtgtacgcat cgacggagag aaagtaacag atgttcacgc caaagcagag ataagagaga 3630181 atatgatcat ccaagtcggc aaacgcaagt ttttaaagct ccaataatct gatattccga 3630241 aacgcttatg acccttcatt cataagcgtt tttttgcagg tataaagcac tgtcttttca 3630301 aaaacgctct ccatcttgca ggaaactcct ttagcatccc gaaatattcc ccaaccatac 3630361 atttagggga ggtttatttt tgatgaaaaa gcttttgact gtcatgacga tggctgtttt 3630421 aactgccggc acactgctct tgccggcaca gagtgtcacc cctgccgcgc acgctgtaca 3630481 aatatcaaat agcgagcgcg agcttccatt caaagcaaaa catgcgtact ctaccatttc 3630541 tcagctaagt gaagcaatcg gccccagaat agccggaact gcagctgaaa aaaagagtgc 3630601 cctattgatc gcctcatcaa tgagaaaatt aaagcttgat gtgaaggttc aacgattcaa 3630661 cattcctgac cggcttgagg gtacactgtc ttcagcagga cgcgatattc ttctccaagc 3630721 ggcgtcgggc tcagctccga ctgaggaaca agggctgacg gccccgcttt acaatgcggg 3630781 attgggctat caaaaggact ttaccgctga cgccaagggc aaaatcgcct tgatttccag 3630841 aggagacctg acttattacg agaaagccaa aaatgccgaa gccgccggag cgaaagctgt 3630901 catcatttat aacaacaaag aaagcctcgt gcctatgacg ccaaacctgt cgggaaataa 3630961 agtcggcatt ccggtcgtcg gcattaagaa agaagacggc gaagcactta cccagcaaaa 3631021 agaagccacc ttaaaactaa aagcattcac aaaccaaacc tcccagaata tcatcggaat 3631081 caaaaaacca aagaacatca aacatccaga cattgtgtac gtgaccgccc attacgacag 3631141 tgttcctttt tcgcccggag caaatgacaa cggctcaggt acctctgtta tgctggagat 3631201 ggcgcgtgtc ttaaaaagcg ttccatctga taaagaaatc cgctttatcg ctttcggcgc 3631261 cgaagagctc ggcctgctcg gctcctctca ctatgtagat catctatcgg aaaaagagct 3631321 gaaacgaagc gaagtgaact tcaacttaga tatggtaggc acaagctggg aaaaagcgtc 3631381 tgagctgtat gtcaacacat tggatggcca atctaactat gtttgggaat ccagccgtac 3631441 ggctgctgaa aaaattgggt ttgacagcct gtctctgaca cagggaggat catctgatca 3631501 tgtgccattc cacgaagccg gcattgattc cgctaacttt atttggggag acccggaaac 3631561 agaagaagtt gagccgtggt atcatacccc tgaagactcg atcgaacata tcagcaaaga 3631621 acgcctccag caagcaggcg atcttgtgac agccgctgtc tatgaggctg tgaaaaaaga 3631681 gaagaaaccg aaaaccatta agaaacaaat gaaggcgaaa gcatctgaca tttttgaaga 3631741 tatcaaataa aaaaagacgg cacttgggtg ccgtcttttt taatccactt ctttcttaat 3631801 ccccagcatt ttctcatcta ggtaatgggc aatctccgcg gcttctttca gctcatctgt 3631861 taattgctta ggaacgtcat tgttcaattt ataataaatt ttatgttcaa ggctcgccca 3631921 gaaatccatc gcgattgtcc ggatttgaat ttctgctttg acgtattcca cacggttcgt 3631981 taaattcaca ggcatctcaa tgattaaatg caggcttcga tagccattcg gtttgggtgt 3632041 ctggatataa tcctttacct ttacgattct caaatcttca tgctgcttca acacattcac 3632101 gacattataa atgtcagaaa taaaggaaca gatgatgcgc acgccggcaa tgtcgtgaat 3632161 atgctccttc atttccttcg tcgtaatctc acagcccttt ctcattaact tattcacgat 3632221 gctttcaaag ctttttacac gggattttgt atgttcaatc gggttgtgtc cgtgaatgag 3632281 gttatattcc tggctgataa ttgagaactt tgtatcgagc gcatctagcg caaatttata 3632341 aactaataac tcatttttcc aatcttccat tactgttttt aaatcgtcca tatgtgttac 3632401 agataaatcc atgttcgtca tctcctttaa cggaacttta tccgctgtcc atgtactaga 3632461 cgtccctgtc tgctgcaagg ttctatgaat ttttttacaa aatgcggtcg attgtaacaa 3632521 aaaaagaccg catgaaacga gcggtctttt ttattatcgg aaatagctga tcaataatcc 3632581 gatcgagagc aggaatccga aaaatgtatt tgtttgggct gttgatttca ttgcgacaat 3632641 catattcatc ggcatttcgt tctggacgaa gcccttcact gcctgaaccg gcttaggcac 3632701 gctcaaaaag acgacaaaca gccatgggct tgcggcaccg gtaataacca agccgacaac 3632761 ccagatataa gcgacggcaa acgacgcagc taacagagta acagctccct tatgccccat 3632821 caaaatcgcc aatgttttgc gtccgccttt tttgtcctct tcaatatcac gaatgttgtt 3632881 cgacaggtta atcgcgccga caagaatcgc aatcgggatg gaaatcaaaa tgctctgcat 3632941 attgatctta tctgtctgaa tgaaaaacga aatcagcaca aacaccgaac ccatgcaaat 3633001 gcctgagaat aattcaccga acggcgtgta cgcaatcggc agcggcccgc ctgtatacag 3633061 gtagccgatc gccatgccga caaggccgat cagcgcaagc caccagctgc tgctggcaca 3633121 aatatagaca ccgagcaaaa tggcaatccc gtatgaggca agagctaatt gcaaaatcgt 3633181 tttaggcttc attccgtggc gtacaatggc ccctccgatt ccgactgatt ctgctgtatc 3633241 taatccgcgt ttaaaatcat agtattcatt aaataagttc gtcgcgatct ggatccatag 3633301 gcaagaaaac agcatagcca aaaacagcag cagatcaacc ttcacataaa acatcgccaa 3633361 aacggttccg agcagcacag gcacaaacga tgcggttaac gtatgaggac gggttaactg 3633421 ccaaaggatc tgccccatgc tttctttttg cggcgctgtc tgaccctcac ccttatttgt 3633481 ttggttcatc ttcctcttcc tttctattaa aaggcttact ttttttcagc cggcagctta 3633541 ataaaaaact ccttttgctt ccttatctat cataatgact tctcccttat ttcacaagat 3633601 accgcaagaa ggcgttttct ttcttattat acgcttctcg ccctgatttc attaggtttc 3633661 tgctttcact tgaacgaaca ggtacagaaa aattttttta agtacattac actttttaaa 3633721 agttaaaaag atcttttgac tccaggtatc ttttccttta ttatgaatca gctcgaaaca 3633781 ttccattctt gcccttgcag gtataaagat tcattttcaa aaacatacgc cgatatatta 3633841 atttgaggga gattagggaa aaaatgaaac tttttgagca tctgatcgtc aaataatcat 3633901 gtgattgtcg aaaaaacggg aagggaattt ttgatatgct gcaattaatg aaacagctgt 3633961 atgaaaaacc cgctgtcaag tggacatgtc atacaggctt ttatttgatg atactgcttg 3634021 ttttgttttt tatgtatggt tttcacaccg cgaataccgg ttcatatatt tataacgatt 3634081 tctaattgga gagagaataa ctatgaaact tttacatgct attcaaacac atgcggaaac 3634141 ttatccgcaa accgatgcct tccgctctca aggccagtcg ctcacgtatc aggaattatg 3634201 ggagcagtct gaccgcgcgg ctgccgcgat ccaaaaacgc atttctgggg aaaagaaatc 3634261 tcctatcctt gtgtacggcc acatggagcc gcacatgatc gtttccttct tgggaagtgt 3634321 caaagcggga catccttata ttccggttga cctgtctatt ccgtccgaac ggattgcgaa 3634381 aattatcgaa agctctggag cagaattgct gatccatgca gcaggactct caattgatgc 3634441 agtcggccag cagattcaga cagtttctgc ggaagaactg ctggaaaacg aaggcggctc 3634501 tgtcagccaa gatcaatggg tcaaagaaca cgaaacgttt tatatcattt acacttccgg 3634561 gagcacagga aatccgaaag gcgtgcagat ttccgctgcg aaccttcaaa gcttcacaga 3634621 ctggatttgt gcagactttc cagtcagcgg aggaaaaata tttttaaacc aagcgccgtt 3634681 ctcatttgat ttgtctgtca tggacctata tccgtgcctt caatcaggcg ggactttaca 3634741 ttgcgtgaca aaggatgctg tgaataagcc gaaagtctta tttgaagagc tgaagaagtc 3634801 cgggctgaat gtgtggacat caacaccttc ctttgtgcaa atgtgcctga tggatccggg 3634861 tttttcacag gatctgctgc ctcatgcgga cacatttatg ttttgcggag aggttcttcc 3634921 ggtttctgtg gccaaagcgc tgcttgagcg ttttccgaaa gcgaagattt ttaatacgta 3634981 cggcccgact gaagcgacag tggctgtcac atcggttgaa attacgaatg acgtcatcag 3635041 ccgcagcgaa tcgcttccag tgggcttcgc caaaccagat atgaacattt tcattatgga 3635101 tgaagaggga cagccgcttc ctgagggaga aaaaggagaa atcgtcattg cagggccgag 3635161 tgtaagccga ggctaccttg gtgagccaga gctgacggaa aaagcgtttt tctctcatga 3635221 aggccagtgg gcataccgaa ctggcgatgc cggctttatt caagacggtc agattttctg 3635281 ccaaggacgt ttggattttc agattaaact tcacggctat cgaatggagc tggaggaaat 3635341 cgagttccat gtcagacagt cacagtacgt tcgttctgct gtcgtgattc cttatcagcc 3635401 aaacggaaca gttgagtatc tgatcgctgc tattgtgcct gaggagcatg agttcgagaa 3635461 ggaattccag ctgacaagcg ctattaaaaa agagcttgcc gcttctcttc cggcatatat 3635521 gatcccgaga aaatttatct atcaggatca cattcaaatg acggctaacg gcaaaattga 3635581 ccgaaaacgc attggcgaag aggttcttgt atgacgcctt acagctcgtt tttattcttt 3635641 atactgcttg gcattcttct tctgccgacg atcattctcg gcttaaacgg aaaaagattt 3635701 caagcataca acatgttcat atctatcatt atattggctt taattttttc gcacgactta 3635761 cacggggtca tcgcgctgtg cctgtttaca atatggcagg tgctcctgat cagcggctat 3635821 ctggcatacc ggcagaaagc gaacagcggc tttgtctttt gcggagctgt tatcgcgtct 3635881 attctgcctt tatttctgtc aaaaatatgg ccgtttcttt cacacccgca gccgcatcat 3635941 ccgccgcata acctgatcag ctttttaggg atttcatatt taacctttaa aggcgttcag 3636001 ctgattatgg aagcaagaga cggactgctg aaagaacagc tgccattgca ccgtctgctg 3636061 tatttcatcc tgtttttccc gacgatttcc tccggcccga tcgacagata ccgccggttc 3636121 gtcaaggatg aacagaaggc ttggacgaaa gaagaatacg ccgacctgct gtatacggga 3636181 atccataaaa tcttcatcgg tttcctgtat aaatttatta tcggctacgc gatcaatacg 3636241 tacttcatca tgaatcttcc cgcaatcacg cacaataaga ttcttgggaa cctgctgtac 3636301 atgtacggct acagcatgta tttattcttt gatttcgccg gctacacgat gtttgccgtc 3636361 ggggtcagct acattatggg cattaaatca ccagaaaact ttaataaacc gtttatcagt 3636421 aaaaatatta aagatttctg gaatcgctgg catatgtctc tgtcattttg gttcagagat 3636481 tatgtgttta tgagattcgt attttggatg actaagaaaa agtggatcaa aaaccgtatg 3636541 gccgtctcaa acatcgggta tttcctgctg tttatgctga tgggggtttg gcacgggctc 3636601 gcgccgcaat atatcattta cggcctctat cacgccgttc tgatgacgtg ttacaacttt 3636661 ttcgagaagt ggaataagaa atataaatgg ctgccgtcca accgctggac aaccattctc 3636721 gctattgtga tcacattcca tttcgtttgc ttcgggtttt atattttctc aggaaaacca 3636781 tttcatcacc accattaaag gagattagaa agctatggat tttaaacaag aggtattaga 3636841 cgttttagca gaggtttgcc aggatgacat cgtaaaggaa aatcctgata ttgaaatttt 3636901 tgaagaaggt ttgcttgatt cttttggaac agtagaattg ctgcttgcga ttgaaaaccg 3636961 ttttgatatt ttagtgccga tcactgaatt tgaccgggac gtttggaata cacctaacaa 3637021 cattgtaaat cagctgtctg agttgaaata atgaaaaagc gttttttcgg tccaattatt 3637081 ttggcgttta ttctattcgc aggcgccatc gcaattccat cttcatggct gacaggcttc 3637141 atcaccgata agcgtgtgaa agagtcagca acagccttga atccgagtat gtttcaaggg 3637201 ctatatttac aagatcagat gctcaaagat ccgacatatc ttccgattta cgggtcttct 3637261 gagctttctc ggctggacga gttccaccca tctaattatt ttcaggtaaa caatgaggga 3637321 ttcacgccat accttgtcgg caaaggcgga tcccagtcat tgattcattc tttaaacttc 3637381 gctgcccaca tggatcagct gaagggcaaa aaaatcgtat tcatcgtgtc tccgcaatgg 3637441 tttattaagc gcgggtctga tgaacagcat ttcgcgccga actattctgc gctgcaaggg 3637501 cttgatttgg catttaacga tcagatcgat cctgaaatta aaaagaaaat gatgaaacgc 3637561 atgcttcgct ttaaggctgt gcaaaacgat gccattcttt ctgagctgta caaagcaatg 3637621 gtaaacggtc agacgtggaa agtgaacgcg ctgaagccgg cggcgaaagt gtattacagc 3637681 atgctggaaa agaaagatct gtattattca acgacagaat catccgggcc aaagcgctat 3637741 atctcgcagt cagtaaagga taagtcatgg tctgaattga ataaactagc ggatcaatcg 3637801 ggcaaacgcc actccggttc taacgatttt cacatcgaca accctgtcta taaaaagctg 3637861 aagccgaaag tgcctaagct gaaagggaaa aacaaaggaa gatcgtatgc ggtgtcaccg 3637921 gaatatggcg actttgaaat gatgctcgat atcctgaagg atgcgggcgc agagcctatg 3637981 tttgtcacca ttcctgttaa cgggaaatgg tacgattaca cgggcttccc gaaaaaagga 3638041 cgcactgact attacaaaaa ggtaaataaa caaatcagag cgaagggctt ccaggttgct 3638101 gatttctcag ggcatgaata tgacccgtat ttcatgaaag acaccattca catcggctgg 3638161 aaaggctggg tgtatgtcga taaagcaatt gacgaatttt ataaaaccgg aaaagtcact 3638221 tcatcctgag catctcatag gacgcggctg catatttcct gctaagattt gtaatagtaa 3638281 aggaatcaca gccaacttaa ttaagaggtg ttacatccaa tgaagatgac aaataatacg 3638341 gttttaatca cagggggttc tgctggcatc gggcttgaac tggccaagcg cctgctggaa 3638401 cttggcaatg aagttatcat ttgcggacgc agcgaagcac gtcttgcaga agcgaagcag 3638461 cagctcccaa acatccatac aaagcaatgt gatgttgcag accgttcgca gcgggaagca 3638521 ttgtatgaat gggctttaaa ggaatatccg aacttgaatg ttctcgtcaa caacgccggc 3638581 attcaaaagg aaattgactt taaaaaaggg acagaggagc tttttgtgga cggtgatgaa 3638641 attgaactta atttccaagc gcctgtccat ttatccgccc ttttcacacc tcatttgatg 3638701 aagcagcccg aggcggcaat cgttcaggtc acatccgggc ttgcgtttaa cccgttagct 3638761 gtttatccgg tgtactgcgc aacaaaagcg gcacttcact cgttctcgct tacgctcaga 3638821 caccagctcc gcgacacgag cgtggaagtg attgaaatgg caccgcctat ggtggacacg 3638881 ggcttaaacc aaaaatcacg cgataaacaa ggcctgacgt accggggcat ttcatctgaa 3638941 gaatatgttc aatatttctt ggacggcttg aaggaaggca aacaggagat tacaaatgaa 3639001 cgtgttgaag gtcttcggga tgccactcgc gccgattatg acaggttatt cgagcaaatg 3639061 aacacgcagg agaattaatt tctcctgctt ttttcatatg aatttcttac aaatttgagc 3639121 aaacctattg cgattatttg ttgaaggtat acaatagaat ataattattt tcaaataagt 3639181 ttgataatat aaacaattta acagcaggga gattgaccat gactaaacaa acaattcgcg 3639241 ttgaattgac atcaacaaaa aaaccgaaac cagacccaaa tcagctttcg ttcggaagag 3639301 tgtttacaga ccacatgttt gtaatggact atgccgcaga taaaggttgg tacgatccaa 3639361 gaatcattcc ttatcaaccc ttatcaatgg atccggctgc aatggtctat cactacggcc 3639421 aaaccgtgtt tgaagggtta aaggcttacg tgtcagagga tgaccatgtt ctgcttttca 3639481 gaccggaaaa aaatatggaa cgcctgaatc aatcaaacga ccgcctctgc atcccgcaaa 3639541 ttgatgaaga acaggttctt gaaggcttaa agcagcttgt cgcaattgat aaagactgga 3639601 ttccaaatgc ggagggcacg tccctttaca tccgtccgtt catcatcgca accgagcctt 3639661 tccttggtgt tgcggcatct catacgtata agctcttgat cattctttct ccggtcggct 3639721 cttattacaa agaaggcatt aagccggtca aaatcgctgt tgaaagtgaa tttgtccgtg 3639781 cggtaaaagg cggaacagga aatgccaaaa ccgcaggaaa ctatgcttca agcttaaaag 3639841 cgcagcaggt agccgaagag aaaggatttt ctcaagtact ctggctggac ggcattgaga 3639901 agaaatacat cgaagaagtc ggaagcatga acatcttctt caaaatcaac ggtgaaatcg 3639961 taacaccgat gctgaacggg agcatcctgg aaggcattac gcgcaattca gtcatcgcct 3640021 tgcttaagca ttggggcctt caagtttcag aacgaaaaat tgcgatcgat gaggtcatcc 3640081 aagcccataa agacggcatc ctggaagaag ccttcggaac aggtacagca gctgttattt 3640141 ccccagtcgg cgagctgatc tggcaggatg aaacactttc gatcaacaac ggtgaaacag 3640201 gagaaatcgc aaaaaaacta tatgacacga ttacaggcat tcaaaaaggc gctgtcgcag 3640261 acgaattcgg atggacgacc gaagtcgcag cgctgactga aagcaagtaa gaaaaaagcc 3640321 ggcccattac aggccggctt tttttacgct tcaattttgt tgaaaaactg cggcagatac 3640381 gctttgtgcg cctctagcat ttcgtctaaa atctgtttgg ccacagtatc ggacgggaca 3640441 agcgggttaa tcgtcatggc aaggagcgca gtttgatagt cacctgtaac tgccgcttct 3640501 gccgcgacac gttcaaagga tttgatttgc tggacaaggc cgcggacaga caccggcaag 3640561 tcgccgacag caattggctt agggccggtt ttcgtcatca cacagttcac ttcaactgcg 3640621 gaatcgtctg gaatactcgc tattgcacca ttattgatcg tgttcaccgg ctgaatgtca 3640681 tgtttatcat tataaatgga gctgattaag ttacatgctg catcactgta gtaagctccg 3640741 ccccgttttt ccagctgcgg cggtttgatc gcaaggtttg gatctttata aagctcgaac 3640801 agctcttttt cgaccttctg tacgacttca gcgcgggtgc cctccgtttg tgatgcttcc 3640861 agttcgtgct ccagcatctc ttttgtttta aaatagtaac ggtgatagcc gcaagggatg 3640921 acattgagcg cttttaagaa atccggttcc cattcggcgc ctgagatatt tttcatcgtc 3640981 atcgcgtttt tcgggtcgcc catcgcctcg atgacttgct ccttcacact tacgccgtcc 3641041 aagaaaacat ccagcccgaa taccatatgg ttcagtccgg caaattggac ttctacgcgg 3641101 tccacatcta catcaagcgc tttggctacg cccattttga tgccgattgg aacattgcaa 3641161 agaccgacga ctttcttcag gttggagtag cgaagcaagg cttctgttac catgccggca 3641221 gggtttgtga agttaacaag ccaagcgttc gggcaaagct cttctatgtc ctttgcgatc 3641281 tcaaggatga ccggaattgt gcgcaatcct ttaaacagac ctcccgggcc gtttgtttcc 3641341 tggcctatca ctccgtattt tagcggaatg cgctcatcct ttgctcttgc ctgcaaaagt 3641401 ccgacgcgga attgggtcgt gacaaagtct gcgtctttca gcgcctttct ccggtcgagc 3641461 gtaagatgaa tgtcaatcgg gacgccagct ttttcaacca tccgtttggc gagtgtgccg 3641521 acaatattca gcttttcttc gccctcgggg atatcgacaa gccataattc acggacaggc 3641581 agctcatcat accgtttaat gaacccctcc actagctcgg gcgtatagct tgaacctccg 3641641 ccaatcgtta caatcttcaa tccttttgtc atatgcttgc tcccctttgc tcggtgattt 3641701 tttcatataa ctcaatgatc tctgcagcca tatccttcac tgtcattgca ttcattaaat 3641761 gatcctgtgc atgaaccatc agaagcgtca tttccgtctt ttctccgccc gcttcatttt 3641821 ggatcagctc tgtctgataa tgatgggctt ttgacaattc ttcagcagcg tcttgaagct 3641881 ttttccgcgc ttcttctgcg tcaccgcttt tcgcagcggc aatggcctcc attgcggagc 3641941 tcctaccgtt tcctccgtga aggatgattt gaaaaatgat ttgttccatt tcctcattca 3642001 cgcgattcac ttcctttctc tacagagccg cttctttgtc atctgttgct gcaggcgttt 3642061 ggaccagctc cagatcgttt tcttctttca gcttctgctt atcccacatt ctgaagaatg 3642121 gatagtagac aacaaaggac acggcaatat taatggcttg catgaccgcg cctgagactt 3642181 ttcctcctgt cgccaagtag cctgaaaaga tcggcggcat ggtccacggc actgcgatac 3642241 ccgccggttt ggcgacaagg ccggtgctca ttccgatgta cgtgagtgtc actgtgacaa 3642301 gcggcgtgat gataaacgga agtaagagca ttgggttcat gacgatcggc attccgaata 3642361 taatcggttc gttaatattg aagatggccg ggccgaccgc aagcttcccg agctgcttca 3642421 tttgtttgct tcgggcgcgc aggaacatcg tgacaaccag tgccaatgtg gcgccgcttc 3642481 cgccaatatt gacccagata tcgaaaaatt gctgggtgaa aatcttagga agctcctcac 3642541 cggcttggaa tgcgatccgg ttggcatcca ttgcgccgta ccaaatcggt gccatgacgc 3642601 cgccaacaat gtttgcaccg tgaaggccgc aggcccataa aagcattttg acggcttcgg 3642661 cgacaaggct tcctccaagg cttcctccca gaatggaaag cggagtcccc aataaaacgc 3642721 ttacaatatt atgaaggctt tcaaacggtg tcgcttcaac aatcagccgg gctgcccaaa 3642781 ttaggaagat gacggcaaag ccggggatta acgcgacaaa tgacttgctt accgccggcg 3642841 ggacaccgtc cggcattttg aagactaaat tgcgctggat aataaggcgg taaatctctg 3642901 tggacaccat tgcgataatc atggcgacaa ataagccttt gcttcccatg agcgaaagcg 3642961 gaatcccgcc gccaaccatg atttctttcg tcgcgccatc cggcataaac ggcacttgat 3643021 aaggtgttgc taataaaaat gccgcaaggg aaatggctcc ggccgacaag gcatcaacac 3643081 cgtatttctc ggcgagccgg taggcaatgc cgaacgcggc gacaagaccc ataatttcaa 3643141 aggtcgcgtc gactgggtag gccagttttt cagaccagga gctgccaaac gtttttgcca 3643201 taaactcagc gtatcccggg atcgggaggt tgccaatgat gaggaaaaag gaaccgatga 3643261 taatcagggg catcgtgagg atgataccat cacgcagcgc ctgcaaatga cgctgtcccg 3643321 caattcttcc cgctataggc atgacctttt cttctaagat ctgattgact ttattcacat 3643381 agcccgcccc tctctatgac acatgtccaa gctgttcagc tgatttcagc acttccgccc 3643441 cattgcacgt tccataatgg acggtattaa tgacgtctac cggaaccccc tttgactctc 3643501 ctaatttttt gagctgcgga agcatgtaac ggacttgcgg accgagaagc aatacatccg 3643561 ctttatcgat atgattttgt acagaatcgc ctgaaactgc ccaaatggta tagtcttttc 3643621 cctgttcctg cgcacttttt tccatcttgc tcaccagtaa gctagtagac atgcctgctg 3643681 cacaaacgag taatatattc atgtaaaaga ccccctagag tttgatcaat tttgtaatgt 3643741 cctgctgttg ctatcatcat attatgaaat cgctttcata aacactcagg gtttttccgc 3643801 aggcaacgga aaaaaggtat atacaggctg tcagctcagc attttttggt caaacacatc 3643861 cgaaagctct tgatatgaac ggcatttgat cagctggttc atcgccgccg ggtcatccaa 3643921 aatgctgcca agcagtttat acatgctttg taaatccgct ttgttctcct tttcgacaca 3643981 aagcagacag acaaattgaa ctcgctgact ctcccaatcg atcggttttt tgagcgtaca 3644041 aacggcccaa aacgttgttt tcgtctgcgg aacaagcggg tgcgggatgg caacaagatt 3644101 gccaaaacac gttggcgaca tgtcttctct ttcaaaaatg gaatctatga tttcttcatc 3644161 ggcaaagccg cattcgacca ctttctgccc taaaaattga atcacttctt cttttgagcg 3644221 cagatcctcc tgaaaaaaaa cgagttcttt ttttaggtag cgattggctt tttccttttc 3644281 atcactcaga atagattcta tttttgtaaa gtcagttccg cctaagatgg tgttaacctt 3644341 cagtactggt acagggagct cttttttaat cggaatggtg ctgatgacaa aatcaattga 3644401 ttcgtaggac atttgatcaa gactataata ctcagccgtt ccaagaatat cgagccgctt 3644461 gccgaaatgg gaacgcagtt tttcgcgcag aagctgggcg cttccggctc ccgatgcgca 3644521 tacaatgata cagcgtttcg gcgggctttc tgtttttttt cgttcaatcg cggcgccaaa 3644581 gtggagagcc aaatatccaa tttcgttttc atgaatctca atacccgttt gttcctttat 3644641 cacgattccg gcaatgatcc cggcttcaaa agcgagtgga taatgttcct tgatcgctgc 3644701 cagcatcgga tttcgaagat tcatgccgta tcggttgcgg ctgatcgccg gcttcatatg 3644761 cagtgccaag ccgattttca gctctttgtc atgcaggatg ccaagcttca gttcacgatc 3644821 aacagctttg atcatggcaa gtgtcagctg atcggtttcc tcttctattg aaaatgtgtc 3644881 ctctccgcat tgtgattgtg tcattcgttt tgtgccaagg agatgcatgg tgatgtaggc 3644941 cgtctcgtct ttcggaaacg taacggaaag ctttgattcc agctctttta cgatggcttc 3645001 tgcagcctgg tactcctttt gatgcaggat atgatccata tctttcggga aaagagaaac 3645061 atagttttcc gttctgatcc gtttacaggc gatagcgata tggataatga ggttattcag 3645121 tcccatgttg gacagaggga tgcggtcgtt tttcattttt ttcaagatgg cggaacggat 3645181 gatctcaatt tcttcttttg gcaaaatatc agccttttca tttaaaacat ctatctccgt 3645241 ttctctttca tcaacaatgt actccgccat gcagtacctc atctgcacct cgtccccgcg 3645301 cagcttgaag ccgtaattcg gacgtgtttc catgacgatg cggtaaggca gcagacgttt 3645361 ctttacttcc tttaaatccg tttggagtgt agattttgag ataaatagtt cttcagcaag 3645421 ttcatcgagc ttgagataat ggtccgccag cagcagacgt ttcataagat aggccattct 3645481 ctcctccggc aataccggca ggcccttttt ttgctgaaat tcatcttgca gcagtgttct 3645541 gaatacttgc tcgtcatcaa tgcggagctt gtagccggag cctcttacag attgtacaaa 3645601 ggcaccgtgg ccgcttagca caccttgaag ttcctttata tcattgcgga ctgtccgcgt 3645661 cgttacgttt aattgcgcgg caaaaaacga acttgtcacc ggggcttcag ccgccatcag 3645721 caagcgcaga atatcacgta gtcgcccatg aagcatgaga aaaacctcct aactagtaga 3645781 tgcagggatt cagtgaatag gcagaaagga tgatgaaggg atgcgaaatg tatataaatt 3645841 ctataatgga gagaatggca agtcaatgaa catccggagg actagaggga aaactgacct 3645901 ataaaaaaac agccgggatc agccggctgt tctagatgcg gacatattct tttgtttaga 3645961 cgccttgcgg tccttcatga tttttcgaac aatcgggtaa atgaccggcg cccatttgat 3646021 aacggttttg atcatctttt tcaaagctcc gattctccct tcttttttct caaccattcc 3646081 cctgattgcc tcttccttaa acatgctaac gcgacacgta cctgtttccc gtcacccaga 3646141 aacgccatgg ataatcgcgt gcctccccgc tgttgtcaat gccgatgcgc gggccggttg 3646201 aaattgcttc cggtgtgtac ccgctttcga tgtaaagcgg ctgttccgtg atccagcgtc 3646261 cgtagtcatt catcgtgacg ccaagcgctt tcgtcagctt tcctggtccg tttgtccatt 3646321 ccctcggact cctgcccggc cttctctcct ccattaacag ctggccttca tgcggctcaa 3646381 tcgccctgat taatactgct tgcgggacat cctcttccgc cgcaacgaca ttcagcaatg 3646441 tatgggtgtg catcacgtat gtatataccc gcccagcttc tgcaaacatg atctcagtcc 3646501 gcttcgtccg gcggttgtta aagctgtggg ccgctctgtc tccagccccc atataggcct 3646561 ctgtttccac aatatagcct gacgctgtgc cttcgtctgt ttcttttaca agaaggcagc 3646621 ccagaagcga tggggcaagc tcaagagcgg ttttttgata aaacgtgatg ggcagcggat 3646681 ttttttctct cgtcacgaat cgacctctcc ttttaccgat ttttgtacat tgtaccattc 3646741 ccgaagcaga tcaaaaaaaa cggctgtttt aaaatctttc cattcaggga atattgttac 3646801 cgttcaaaaa aggagggcca accattgaaa gatgatcatc aaaacaagca gcaccaatca 3646861 aatgcccaag ggagcgagga agcgttttct cataagacat ccgggaaaaa cgagtcagag 3646921 gataccttaa cgaataggca ggggcatcct gttactgaca accagaatgt gagaaccgtc 3646981 gggaatagag ggcctacaac acttgagaac tatgattttc tcgaaaagat cagccacttc 3647041 gaccgggaac gcatcccaga gcgggttgtt catgccaggg gagcaggtgc acatggatat 3647101 tttgaagcgt acggaagctt cggagacgaa ccgatttcaa catacacaag ggccaagctc 3647161 tttcaggaaa aaggcaagaa aacaccggca tttgtccgtt tttcaactgt gaatcatgga 3647221 aaacactcgc ctgaaacatt gagagacccg cgcggttttg ctgtaaagct atatacagaa 3647281 gacggaaact gggatttggt cggaaacaac ctgaaaatct tttttatccg cgacccgctg 3647341 aaatttccgg atcttgtaca cgcatttcag cctgatccag tgacaaacat ccaggatggt 3647401 gaacgtatct tcgatttcat ttctcaatct cctgaagcga cacacatgat caccttcttg 3647461 ttttcgcctt ggggcattcc ggccaactac cggcaaatgc agggttcagg cgtacatgcc 3647521 tataaatggg tgaatgagga gggcaaggcc gttctcgtga aataccattt tgaaccgaag 3647581 cagggcatcc gcaacctgac acagaaggaa gcagaagaga ttcaagggaa aaactttaac 3647641 catgccacac aggatctata tgacgcgatt gaaaatggcg attatccaga gtgggaagta 3647701 tatgctcaaa tcatgagcga tgatgagcat cctgaactgg actttgatcc tcttgatcca 3647761 acaaaactgt ggtataaaga cgatttccca tggaaaccga tcggcaaatt ggttctgaac 3647821 aaaaatccgg aaaactacca tgcggaagtg gagcaagctt catttggaac gggagtgctt 3647881 gtcgacgggc ttgatttttc agacgacaaa ttgctccagg ggcgtacgtt tgcctactct 3647941 gatacgcagc gctaccgtgt aggcgcaaat tacctgcagc ttccgatcaa ctcgccgaaa 3648001 aagcatgtcg ccaccaacca ggaaggcggg caaatgcaat atcgggtcga tagagcagaa 3648061 ggacaaaacc cgcacgtcaa ctacgagcca tccattatgg gcgggctgaa ggaagcgaag 3648121 caagacggaa aagaccatac gccgcatgtc gaaggtgatg taaagcgtga agcgattgac 3648181 agaacaaaca acttcggaca ggctggagaa acgtaccgga gatttactga atttgagcgg 3648241 aacgaattga ttacgaattt ggtgaatacg ctttctacgt gccgaaaaga aattcaggat 3648301 caaatgattg agaatttcac aaaagctgat cctgactacg gaaaacgcgt agcagaaggg 3648361 ctaaaaaagg tctccgaaaa caacagcaac gggccgatcg gcacaactga aacggaacag 3648421 gctgcaaagc aggctgaaca ggagagtcat ccgtctgatc cgtattaaca acagcgaaca 3648481 gggctttttt agaagccctg tttttttatt tttctattga aacgctttca ataattgtgt 3648541 tgtacttgga aggaaagggg tggagagata cgatggaatt acagcaggac ttgattcctc 3648601 agaaaaaaac aatcggcgct ttagatcacg ccgttttttt atgcatggta ttttgtttct 3648661 ggttttcagg ctatatttac gttcctgtat tcagtctgta tttggaggat ctgcactttt 3648721 catatggcgc aatcggcatc attctcggca gctacggggt cacgcaaatc cttctgcgat 3648781 tcccgctcgg ccttttgtca gacatcctgt tttccttgcg caagcaattg ttaattgccg 3648841 ggttcggctt ttccgtcctc agcagcctgc tttttctgat gtttgattct ttcttcttcg 3648901 tgctggccgc ccggcttttc gcgggaatca ctgcttctac gtgggtgatg gcgaccattt 3648961 tatacgcaca ttatttcaac aatggcaatg catcaaaagc aatgggcatc atgcagtttt 3649021 ttaccgtcat gcctcagttt gccagcattg tgttctgcgg gctcgccgca gcccatttag 3649081 ggaggcaggt tcctttttgg atggcgctgg cagcttctgc cgcaggtctg gtgatctgct 3649141 gctttattca ggatccgtct gctcctcccg caaaccgtgg caccattcgt gtcaatcagt 3649201 acatcaaaga tacattgcgg ctgccaaagc tgaagctttt caccatcctg tctatgacgg 3649261 cccatgccgt attatttatc acagtgtttg gttttacgcc gctttacatg aatcagctcg 3649321 gaatgggcga cgcggagctg ctttgggtga tgagcgcctt tttcctccca cacgcagccg 3649381 ccacattaag ctttgtgttt ctgcgcttta caagccgtat cgcttactcc gtgatgctca 3649441 ttagtttcgc tgtcaccggg gtctgtttgc tatatgttcc ttttttagct gcattgttca 3649501 cggtttgcat cacacacgcc tgtattgggc tggcgctcgg cttcgttttt cctctgctgc 3649561 taagccatgt cgtcgaaatc agttctgccc gtttaaaaat gtcagtgatg gggttttacc 3649621 aatcatttta tgcgctaggc atcttcctcg ggccccttct tgccggaaaa atcgcacagc 3649681 ttatcgggct tgcgggagtt ttttatggag ccggttctct ggcatttgcc gccttttttg 3649741 tgatgctcgc gcaaaaacgt aacatgatca attaatagct ttcataccgc cggaagcgcc 3649801 acacagaaaa cacggccaga agcatgatgc acagaatgga gaaagtgagt gaccatccga 3649861 aaaaatctgc ccgctctcca tgaagaagga tatgctccgc ctgcttgcaa atctcagccg 3649921 gaagccactt cgcaccatct ggaaatagtg aaacagcaaa ggaaacggct gctgtgagcc 3649981 cgatcccgca agccgcagct gctccgacag accggaatat cgtacttccg gcaaggccgg 3650041 cggtcacaat aaatatcacc caaagagcgt aaaggccaag gcttgcggca aagcggctga 3650101 atgatgcgtc ctcaaacagc agccggacgt aatagtaagc aagcccgtat ccagctgcaa 3650161 acgacataat gccgatcacg ctttggatga gccatttact cacgatataa tgggctgccg 3650221 tcacaggccg cgacataatc agcgctgtta ccccttgatt tctttcattg gctacactgc 3650281 ccatcacgct aaagatgacc agagccatgc caagcgtgtt gaattgagaa agcgtgctga 3650341 ccatcacttc agacccggag ggcatcgtaa aactgatttt catgccgtca ggaaggttcc 3650401 ctccatgtgc gatgatttcc ggcatataat aaatggtcag cggctgtgtc agcccgacga 3650461 tcatcatcgc aatcggcagc caaatcagct tgccgctttt ccatccttcc agccactcct 3650521 tctgcaatag cgccatcatc accttcatgc gtgcaccacc tttagataga cgtcttctag 3650581 agactccgtt ttctgttcaa agcgggtgac ggtcaatccc tttcggatac agtcacttaa 3650641 taatgaccgg ccagcgtgta tatcaggcag ctcgaaaacc gcttgggacg gattcttata 3650701 gacaatagct gagacgtaag gcttctcttc aagccaacct tccagcttct ctttcactga 3650761 aagggtaaaa acgttcgttt gctgctgttg tttcagctcc tgtaactcgc ctttccatga 3650821 aatctcaccg tttttcataa tcaccacttg atcacacacc tgttctgcat cgtgcaaaac 3650881 atgtgtagaa aacagaacgg ccatatgctt tttcagctcc cgcatcatgt ccagcacctc 3650941 gaaccgtcct gtcggatcaa gcgcagacac cggttcatcc aatatcaaaa acttcggttt 3651001 atggagcagt gcctgtgcca gaccgagtct ttgtttcatg cctcctgaat agcccccgat 3651061 ccttttgtgc gccgcttcgt gcaaaccgac aaattccagc atctcgccga ttttctcttg 3651121 gcattttctc ttcgaaaggc cggacagtct ccccgcaaat gtcaaaaatt catttgcggt 3651181 catccacgaa taaaaagcag gatactgcgg gaggtaccca atcaaacgcc gatccagctt 3651241 tttctctcct aacagcttta tggttccaga ggttggcgaa agcagtccgg ccagcatttg 3651301 cagagtcgtg gttttgccgg ctccattagg tcctaatagt gcgacacact cattttcatt 3651361 cacgtgaaaa ctgacattct ttacagcttc atggtgcctg tacgatttgc ataatgattc 3651421 aatagacagc atatcggctt acctttgctt tctgccgacg gtgaaaaata aaatcggccc 3651481 gataatattg atacatacga tgattgcagc ccacatccac tttggcccgt tcgtccgctc 3651541 ttcttttata cagctgataa gggcaaacac cgccaaagcc agctgtaata caatcagcgg 3651601 caaaatcatt tcccaagaaa tattcattgc ttgatccccc ttttcttccg atccggccta 3651661 atgacaaaaa agtaataaca aatcagaggc atcggtgctt gaatcaatcc gacaatcccc 3651721 caaacccatg ccatgtgatt acgttttttc gcatcaataa ataaaaagat tccctgcgcc 3651781 aatacgatga gacaagccgc aaccgttatg ataatttctg tttgtgtcat ccgcgtttca 3651841 cctcgcattc gccgagatgc ctttttttct cagccgcaat caaaatcggc agcaccgcaa 3651901 gcacacaaac ctgaagcaca ataaacacag caggagcttg agtgaaagct aagattgcag 3651961 cactcacaac catcagcgcg cagaatacaa ataaaatgat ctcttgaaga agtttttttc 3652021 tgtattcagc tttcatttgt gacagctggt gaagcagttc tttttgattc ggtatagagg 3652081 gattggctgt ttgatcaatt tttttccatt ctgactttaa atgatcagaa agcttttctt 3652141 tattcatcat cccactcctt tctgatttgc tggagccctt tatgaactct ggactttaca 3652201 gtgccttctt tgatttgaag catcaccccg atttcagcgt aggtatagcc gtagtaatgc 3652261 cttaataaaa ccggtgtgcg cagtttaggg tccagctttg aaaacagatc gagcgtttcg 3652321 ctccactctg cccctttcgc cgacacgtcc cacttgatct tgcggattgt ttcctccgta 3652381 actgtctgat tccgtttcca ttctctcttt ctctttttct ggtgatcgag atagagccgc 3652441 gatgcaatgg agatcagcca tgtggagaat tttgaacggc cctgaaagct tcttaaatgg 3652501 atgtaccctt tcagaaaggt ttcctgaaca agttcctcgc tgagatcggg gtgaagggaa 3652561 agctttaaca agtatttata taagaaagaa tagtgatagt ggaaaagggc tgtaaacgcc 3652621 tcgtcgtttc cctctttcgc ctgctggatc agccgctgtt cttcttgtgt atccaatgac 3652681 cgtgatcccc ccttttttgt ttttctgcct tatgagacga caccggattc aaaagcgttc 3652741 atctttttta caattctttt cagccattga cagatcaggc ttcccggccg tttggctgca 3652801 tatccttatt tgtaaacccc cttatagtct gttaagctat gactttatgt cgatttcaaa 3652861 aaaacatcca atatggagga cgatgcattg aaagtagaaa ggcgaacgat tgaatatatt 3652921 ccgaatgaag aaagacatgg taaagcgaaa gatttatttc ccgtatggtt cggggctaat 3652981 atgcatatca ccacgttagt gaccggcacg attcccgttg caatgggact taatctgttt 3653041 tggagtgttg ccgctattat ttgcggaacc ttaatcggtg ccatatttat ggcttctcat 3653101 tccgcgcaag gccctcagct aggcatcccg caaatgattc aaagccgtgc ccaattcggc 3653161 gtaatcggag cgattcttcc cctcttctta gtcatgttta tctaccttgg tttcttcgca 3653221 agcagcacga ttctggcggc cggaacctta agcagctttg ttcccatccc gggatcatgg 3653281 agcattatag gcttaagtgc cgtatgtttt ttactcacca ttttcggcca tgatttgatt 3653341 cacaaaatgc aaaaaatcct ttcttggacc tcttttgctg tattttttgc tgcaacgatt 3653401 ctcatttttc aattgccgat tccggcaggc agctggatac ccggagcgat tgatctgcca 3653461 attttcctag tggcagtcag cgcagttgcg acgtggcagc ttgcctacgc gccgtatgtt 3653521 gccgattatt caagatatct gccagttaaa acaccggctt caaaaacatt ttggtacagc 3653581 tatgcaggta catctgtcag ctccatctgg atgatgctgc tcggcgcatt gctgacaacc 3653641 tcacttcctg actttacggc aaactcaggc agccagattg tccaattgtt cggtcccttc 3653701 tcgtttatta tgctgatcat tgtgctattt gggcaaatgg caatcaatgt ttttaacctg 3653761 tatggggctt tcatgtccac gacaacaacg ctggagccgt ttctgaaatt aaaagtcacg 3653821 cccaaagtca gaatcatcat gatcctgggt gtcacgcttg tcggcacagt cttaagccta 3653881 ctgggacaga gcaattttat ggaactgttt ttgaatttta tctttttcat cagttatttc 3653941 ttaattccgt ggacggcaat caatttagtc gattactact tcgtccgcca cggaaagtat 3654001 caagtcaaag ccatgttcga cgtaaacggg ccttatggaa aggtcaattg gatcaccaca 3654061 attgcgttcg ttctgtctat cttgctggaa attccgttta tcaacacaag cttttacatc 3654121 ggaccgcttg ccaaaatgtt tggcggcgga gacatcgcat ggattatcgg cttggccgtg 3654181 ccttctgtgc tttactatgt attaatgaaa ccgcgtctga aaaaacgggc ggggtatcaa 3654241 gaaaagctgt cttctctctg aagacagctt ttttatcatt caaatcgttt ccacacgcgg 3654301 ggcaggatgt cagatagctc atgagcgagc aacgtatgag cggagtgctc gtccgtccag 3654361 agctcggcgc acgcaccatg caaatagacc gcgtttaata cggcgtgctt tggatcttca 3654421 tggcagcaga gcatccccaa tatcatgccc gtcagcgtgt caccggttcc gcccttggcg 3654481 agcgccccgt ttccggttgg attgagccag cagtctccat caggaaacgc gatgacggtt 3654541 tggtttcctt ttaacacaat gacagtctgc agctgagccg cccattcctt tgcatattcc 3654601 gctctttttt tctgcaattc gttcacgggc acccctgtca ttcggaaaaa ctcgcccggg 3654661 tgcggcgtga ggatgacggg gccctcccgt ttcggatatg tgcgcttcgc cagcgctccg 3654721 gcatccaaaa taacaggaca atcagccgta agcacatgat cgactgcctg ctgtacgctt 3654781 tccgtttgcg gaaggcccgg tccgatggca atggcccggt acgtctcttc aagctgagca 3654841 tccgccgcct ttttccagcc gtcacgccaa taggtcgcct cgggcaaaac aggaacaatt 3654901 agcgggatta cgttttctga tgtaccgatg acaagcttgc cgagaccgct ccgcatggcc 3654961 ccaagccctg caagcagcgc tgctcccggc atgtcgtcac ttccagccag cagcaaagcc 3655021 gtaccgtacg tgcctttatg gctctccgca tctctttcag gaagcgtggc ccttacatgc 3655081 tcttccgtcc aaaatggaac attcatctct atccctcctc tgctttcttt tcctattttt 3655141 cctgtccctt ttctttttca aacaaaaaag acagcctttt agggctgtct tttattttac 3655201 aggaacatca aggtgataca ggcggcgata tcgttcgttt gccgccagca gctcctcatg 3655261 ggttccttcc atttctgttt tgccgttttc gagaaatacg attttatcgg ctgcttccac 3655321 tcccgcgaga tggtgtgtaa tccataaaat cgtttttcct ttcagcacct caaacaccgt 3655381 ttccatcaat tcacgttcgg taataggatc gaggccgact gttggctcat cgaggatgat 3655441 gatcggtgta tcctgcagca aaatcctcgc aagtgcgatc cgctggcgct ctccaccgga 3655501 aaaacggatg ccggtttctt gtacagaggt atgatatccg tcaggcaatg actcaatgta 3655561 gtcatgcagc ttgacctgct ttgcggcgcg gcgcacatcc tcgtcgcttg cttctccgtt 3655621 tccgagcctg atgttgttca aaatgcttgt atcaaacagg tgcggttttt gatttaacac 3655681 ggccaccgca tccgcaatct gatcctttaa cagcgctgtc tccactccgt ttaacgtcac 3655741 agaaccggag tccggtttca aggcgccttc gattaatgca agcgatgttg atttcccaga 3655801 gccgcttcgg ccgagcagcg ccattttttc tccttggcgc agcgtaaagg aaaagttgtg 3655861 cagcacttgg ctgctgttgt cataagaaaa cgtcacatca cgaaaggcca aggtgacatc 3655921 ttgaagatcg agaatttgat cccctgattc agtttgtgac gcctccggct gaggagccac 3655981 attgttcatg cgtctgatag aatcctgata gcccggcact tcgcctaagg catccgaaag 3656041 cggcaaaaag gcttccgtca acggaaacac cactagcaca aaagcggcaa tcatcgtttt 3656101 agcgagctcg ccgtccgctt gctgtcccgc tgtccaaaac agcatcagca aaataaggcc 3656161 agcgacaagg cattgcgcag caaagtcccg ccatcttgta aagcgttgtt ttttccgttc 3656221 aagctcaaac caatcacgtt cctctttttc ataagcatca ataaaagcat gccggcgtcc 3656281 gctgaacatc cagtcgctga cacccatcac agcatctgtc agacggctgt acagcacatt 3656341 ccgtccgctt ttcagcttcg cattcttcgc tctcgtcacg agcaaagaca caaccggaaa 3656401 caatacaaca agaacaaaca aatacagcgc aagcaatatg gcaaacggcc aagagaagaa 3656461 gccgagcgct atcactgaca cagcatacag gagcaaggct gagatcgcag gaaaaatcgt 3656521 ttttaagaaa gcatcctgca aatgctcaat atcctcagac aaaatgccga gcatatcccc 3656581 cgtgcgaaaa cgggaacgca gcatcaaagc acccggctca agcatattgt aaaggcggac 3656641 gcgcatgtca gatacgattt tcaaaatgat gtgatggccg acgagccgtt ccacatatcg 3656701 cgacacagag cgcgcaatcc caaaggtgcg cacagcgaca atcggcacat aaatgagcag 3656761 aatgttttcc ggccttgtcg ccgctttaga aatcaaaaaa cctgaggtga acatgagaaa 3656821 agcagcagaa aaaatcgtca ccgcacccaa aaagataacc agaacgaaca ggcgggcatt 3656881 ttgcttgata tacggcaaaa tccattcttc tttcttcatg ctctttcccc cagttgtgcc 3656941 ttcacgagtt tggtatacac accgtttttc tccagcagtt cattgtgagt cccaatttcc 3657001 gcaaccctgc ccccgtcaag cacgataatt tcgtccatat cgagcatcca gtgaaggcgg 3657061 tgagtcgcga gaaagacgag cttatcctca aataaatcca gcatcgtttc ttttatttca 3657121 tattctgttt cgatatcaag atgggcggtc ggctcatcca gcagcaggat cggacggttt 3657181 cccaaaaagg cgcgggccag cgcgacacgc tgtgcctggc cgccgctgag cgcccggccg 3657241 ccttccccga tccgcccctc taatccgtca ggaaggttgt tcaccagctc cgtcagtccc 3657301 gctgaggcag cagcacgtgt tgtatcctct gccgaagcgc ttggatggta gaagcgaatg 3657361 ttgttgccaa gcgtatcatc aaaaatgtac ggatgctggg gaatgtaaag aaggttcttc 3657421 tgccagctgc cgtcctgcaa atgggaccgg cttgtaccat taacctcaat catcccgcca 3657481 tccggctcta aaaatccgcc gagaatatca attaatgttg attttccggc gccgcttgca 3657541 ccgataatgc cgattttttt cttgcctttg aatgagagat gaatatcaga caccgaacgg 3657601 ccgactgaca cgcctgacag cttcagctca tcctgatcgg accaagcttc gagctgaagc 3657661 ggcgtctctt ctttaaaacc aggctgcgac aaaatctctt gaatggtttt tcctgcttcc 3657721 tggccgttca gcgttgcatg ataatcattc cccacttccc gcaccggcaa aaaatactca 3657781 ggcgccagaa taagcgccgt taaagcaggg ccaagcaaaa tatcgccgtc aatgaggcgc 3657841 aggcccagaa atactgcgac tgtcgccacc gacagcatcg tgaaaaaatc gagggcgaat 3657901 gatgacaaaa acgccacccg gagtgtgctc atcgttgcct tgcgataccg ctcactcaca 3657961 tagaaaatat ttttgctgtg tgacttgctc aaacctagga aacgcaatgt ctccagcccg 3658021 cgaagagaat caacaaaatg attggaaagt ctctgatagg atttccactg acgatccgct 3658081 tttctctgcg cgacaaggcc gaggagaatc ataaagatga tcagaatcgg catagcagcg 3658141 actaaaatga tggctgatgt ccgatcctga aaaaacacat aaatgacaac tgccgcaggc 3658201 acaatcgcca tgctgaccat tttcggcaga aacagctcca ggtagcggcg gaactggctg 3658261 atgccttcca tcgccagcgt caccatttgc cccgtcccct ctttctttgc aaagcggggg 3658321 cctaatcgga acagctgatc aagaaaactt ttcctcaaat ctgctcctgt ccgggcggcg 3658381 tattgataga cgattttctg tcgcgccacc gtcatcccgt gccgggcgat aaaagcgatg 3658441 aggaaaaagc cgatcaccgg taaaagggag gtaatgccct tcccgttgaa cagtccggtt 3658501 acggcctcac tcagccactc tgcctgcata ataatggcgg ctgtctgaat caacgttaaa 3658561 caagtaatca aggtgagaat ccgcttcatt cctttatatc gaaacaggtc ttttcccatt 3658621 aataagtcat aggctcctta tggctgacgc gcttccggaa gacataatag ctccagatct 3658681 ggctgccgat gacgaacggc aatagcgtta atgctgcaat tgacatgact ttaagcgaat 3658741 aatctccaga agaagcgtta gctactgtta aatcgtatgc gctatgaagc gagctgacca 3658801 ttacacgagg gaatagggaa ataaagatca ttcccacggt cagcgccaga ccagcgcctg 3658861 tcatcccaaa tgtccagccg tcttttttct tacgaataaa tacagccgcg agcataaagc 3658921 agatgacaat caaaacagcg agcggaatgg taatctcgcc gcggcgtgta aacatgtctg 3658981 tctgatacgc agaaagggcc gcgaaggcaa gaaccgctac aaaaacaaca cccattatct 3659041 tttgcgccat tttccgggcg cggttttgca aatcaccaat cgtacgcagc gtgataaaca 3659101 ttaatccatg ctggaagcaa agaagcgtta ccgtcacacc gccaagtata gaatatacat 3659161 tgatataatc agatacatgt gcgtgaatgt tcatgtcggc atcaatcggc atcccgcgga 3659221 ataatgtcgt gaacagcaca ccaagcacaa acggaggaat tagactgccg aaaaaaacga 3659281 cccagtccca aacctttacc cattttaaat gatccacctt gccgcggaac tcaaacgcga 3659341 ccccgcggcc cattaacgca agcagcacta tgacaaacgg aatgtaataa ccgctcagca 3659401 tcgttgcata ccagtttggg aatgccgcga aaatggcgcc tgcgccagtc aaaagccaca 3659461 cttcattcgc gtcccagaac ggcccgatcg tgttgatcag cactctgcgt tctaattcat 3659521 tatggccaag aaaacgggtc gccatgccga ccccgaaatc aaagccttcc aaaaagaaga 3659581 atcctacaaa caatacagca acgagtataa accaaagatc atgaagagat gccatggtat 3659641 acctcctgac taaatggatc tgttgataca ggcacatcat gatgattatc atgctccgca 3659701 ccttttttaa tctcacggat aaacaagaag acaagcagtg caccaagaat catgtacatc 3659761 acaccgaatg cgatgattga gaataacaag gaacccgctg ttacgttagg cgacacagat 3659821 tgagcggttg tcattaaccc cataaccgtc caaggctgac gtccgatttc tgtcataatc 3659881 cagcccgcgg agtttgcaag aaacgggaag gaaatcaacg cgatcatgat gcgcaaatac 3659941 catttgctgt tttcaagctt tttacggcgg tttaaccaaa ggccgcctaa cgcagcaaga 3660001 atcatgacaa cacctgctcc taccatgatg cggaagctcc agaatgtcgt tttcactggc 3660061 ggaatgtagt cgccttttcc gtatattttt tcgtactcag cctgaagggt tttcatccct 3660121 ttgacacttc cgctgaattt ctgataagcc aagtagctca aggcataagg aactttgatt 3660181 tcatttgagc ttttttcatt ttttgtatcg atcgtcgcaa aagcggtcca agcagcaggg 3660241 tcaccgctgt cttcccatag gccttcactg gcagccattt tcatcggctg tgattccatc 3660301 aagtgctcag cctgcatgtg tccgctaagg ccgacgccaa gaccggcaca aagaccgacg 3660361 atcattgcga gtttaaaaga ttgcttaaag aacggcactt cttttttctt cagcagttta 3660421 aaagcactca ctccggcaat aaagaaagct ccagtggcaa gcgcaccgaa aataacgtgc 3660481 gggaattcaa cccaaagctg agggtttgta atcaacgcgc caaaatcatt catttccgcg 3660541 cggccgtttt tgatcgtaaa gccgaccggc tcctgcataa aggagtttgc tgttaaaatc 3660601 cagaaagatg acatgatcgt tccgaatgat acgagccata tgcagagcgc gtgaattttc 3660661 ttcggcaggc ggtcccagcc aaaaatccat aatccgataa aaatagattc catgaaaaac 3660721 gccaataatg cttcaatcgc aagcggagcg ccaaatacat ctccgacaaa acgggagtaa 3660781 tctgaccagt tcagtccaaa ctggaattct tgcaaaatcc ccgttacaac accgactgcg 3660841 aaatttatta agaataagtg tccccaaaac tttgccattt tgagatacag ctcatttttc 3660901 tttacaagat aaagagtctc catcaacgca accataaaca caagcccgat agacatcggc 3660961 acaaacaaga agtgaaacaa cgttgttgat gcaaattgta tgcgggctaa taccaattca 3661021 ctcatgcttt ctcctccatt tccggttaaa actgttaatt tgctcactac ttcacaaata 3661081 gaaccgagac tttgatcagt aattcacaaa atagacgaaa aaaatattgc tcaatatttc 3661141 acaaatgtgt caaaaagtca tccaatatga tgcaagattg ccagactgac caaatgacac 3661201 aatctctgac tggttcatat taagtacttt acaacgattc atttcaaaaa taaagcctaa 3661261 aatacctaaa aagtcccgca ctatgtgacg gatttttgtc tattttgttg cttatttatg 3661321 tcggctgcta ggataaatga ccctttatta tcgtacatca acacatcgtt ccttgcgaac 3661381 aaaatgcttg cccccgcccc agcactcgag tctcagcatt ccgtcttaaa ccgattttag 3661441 tcagaatgcc tcttttcatt tgaaccggta agaggagaaa agttgaatag taaattttta 3661501 atatattaat aatttcaatt ttttagtata cttaacatag tgaacaattt cactgcatca 3661561 agaatagggg aggtttttca atgggagagc ttcaaacaca catgcaattg caaacggata 3661621 caattcacga aggggttcga aaagagaatt ggtttgcgaa agccatgaat ataaaagtag 3661681 gcatcatacc gcttcctgtg tatgccttgc tgtttatatt aatcactgtt tttgttatgc 3661741 atcacgatgt aaaaagtgac attttgacat ccattgccgt catggcgttt ttcgggttta 3661801 cctttgccca aatcggcaaa tcgataccga ttgttcgttc tatcggcggc ccggccatcc 3661861 tagctacttt tattccgtcc gctgtcgtgt actatcacct gctgcctaat gatatcgtca 3661921 aatccaccac agaatttaca gaaaactcaa actttctata tttgtttatc gccggtattg 3661981 tcgtcggaag cattctcggc atgaaaagag aaacactcgt aaaagcattc atgaaaatct 3662041 ttattccgct tattgtcggt tctgtcacag ccgctattgt cggactggct gtcgggacat 3662101 tgctcggact cggatttcag cataccctgc tgtacattgt cattccgatc atggctggag 3662161 gagtcggaga aggcgctatc ccgctgtcca tcggatattc tgacatcatg cccatttctc 3662221 aaggggaagc gtttgcactt gttctgccat cgattatgct gggcagcttg tgcgcgatta 3662281 ttctagcggg attgctgaac cgaatcggaa agaaaaaacc ggaatggaca ggcaacggca 3662341 aagtggaccg ctccgaagaa gagtcccctg cgctggagga atctcaaagc ggacagcaaa 3662401 tgttcaacct ttctttattt gcgtcaggcg gtatccttgc tgtttcttta tacttagtcg 3662461 gcatgctcgc tcacgatttt ttcggttttc cggcacccgt tgccatgctg ttactggctg 3662521 ttctaatcaa gctgttcaga ttggtgcctg cctcaattga aaatggcgcg tttggagtgt 3662581 cccgcttctt ttcaacagct gtgacctacc cgcttctctt tgcgattggg gtatccatga 3662641 cgccgtggga caagcttgtc gccgctttta acctcagcaa tattatcacg attctgtctg 3662701 tcgttgtgac catgatggcc gttggcttct tcactggaaa atggctgaac atgtatccga 3662761 ttgaaaccgc cattattaat gcatgccatt ctgggcaagg cggcacgggt gacgttgcca 3662821 ttttaagcgc cgctgaaagg cttgagctaa tgcctttcgc ccaggtgtct acccgcatcg 3662881 ggggcgcgat tacagtatcc ttaaccttat tgctgctgca ccagttttat tgatccccgc 3662941 aagcaagttc ttcgtcaaac gaaagagctt gcttttttgc atgtccatgt ttttgcaagt 3663001 tcccatccca tgctatagta atagttggaa atactagata gaaaggaatc tggcatgcct 3663061 atgggaactc atctatttct ctttatgctt ctcgggctgg gattttattt gatatcagcc 3663121 ctagctgcaa aactcattcc ggccatagac ttctggattg atattgttct atgggtcggc 3663181 gctgcggctt acatcttctc tcatctctca ttcatggacg gcattgtctc actcgcgaca 3663241 atgttctact gctattggac cgcaatggat ctcattgttt cagagcgtgt ggaaaaacct 3663301 tcgggagact ggcaggaaat cgagcttgcc aaaaacaaaa cacgcctcct gtcagacatt 3663361 acgctgaccg ccattgtgtt tgcaggggct gtcatttttt tcatctatgg acctgacaca 3663421 agccctctca aatatgtgat ccttctcgga atgatctccg gcggaggggc acttgtgaag 3663481 cgaatactga atgtttttag cgtaaaggtt ttttattcag cagccttaga aaaattgcat 3663541 atcagctcac actatgaaac ccgtacatac ccgctttccg atttgaagaa cattcagctt 3663601 gaatcaacag cagatctctt aaagctccat ccgcttctga cgatgtattc atcccgttta 3663661 gatttgacaa caagctttca gcaagtcatt aaactgtctc ttcccggcga aacactgttt 3663721 ctgacggtga aggaaccgca aaaatggaaa acaattcttc aggaatacac agatgcagaa 3663781 aacaatgtgg acaatgtgat ttctgttttg ccgttttatc atcgaaaaaa tgtgaagcgg 3663841 ctgctcggta agctttattt tgccgccagc gtaaaagggg tatccgctta cgccttattg 3663901 gtgctcgcgt tatacgcatt acacgcctct ccatgggtca tggctgttgc cgtaatccta 3663961 tattgggtat tcaacatgta tatgtcagac cgtgtgttgc gggcggcgat ggacgccaag 3664021 tcttgtcatc atccgcatgt acaggccgcg gccgataaga ttttcagatc ggccggcatt 3664081 tcccatgtcc gcatatacga aacggagagt gatgattaca acggaatggc agtaggcatg 3664141 aatgtcggga ggtcaatggt catcctgaca agcgccacac taacacttcc acagcgtgtc 3664201 attgaaggca ttctggccca tgaggcgatt catatcaaaa aacgtgacgt tctgtcatca 3664261 cagcttttgc gttttctata tcttggagct gtcgtgggga ttttcctctt gtttgagcag 3664321 catatcaccc atcccgaggc ccacaaaatt gcgctttggg ctttcattat ggcaatcatt 3664381 atcctattcc agctctatca atccttttgt tcacaatgga tggaggtgcg tgctgacaac 3664441 cttggcgcat cattgctgga cggcggttac aaacaaatgg ctgaagcctt gagaatcttg 3664501 gcggttcggc aagatgagga tatacagaaa caaagtgcct atagctctga agcaggtgaa 3664561 gacgagcttc aaattgattc tctcacccgt gataaaagct ggtttttcag attgattgat 3664621 tttcagttcg ctcctcatcc tcctatgtat tggcgtgtcg gcactttatt gtcaaacaaa 3664681 ggacatgggg tgctaaagcg ctggctcaga gaccgactga aagaatcgat cactttgaaa 3664741 tgaaaccggt cagcgtttca tccgtataac agatatggtg aaaaaaggga gtgacgcgaa 3664801 gtgattgtga tcatcttatt gtttatatct attattgttt ttctttcagt cattcagccg 3664861 cagccctcga aaaacaaaag ccgccagcag gcggacagcg ggtatttcgg ttattcagat 3664921 catagctcac accatgatgg atgcagcagt gacggaggtt tcagcgattc cggctgtggc 3664981 ggcggagggg gcggcgatta aacgccgcct ttttttattt cattgattcg atgtacgcac 3665041 caaaagccga gcctgacatg cctggggaca cgcgcacacg atggagggca tacattccct 3665101 ggtctctcga agccgcgccc ggttctgtcg tcacgcccat ttgatagcct gttttttcag 3665161 cggccttcag cgtctcctca ttgtagcgcc ctaccggata gctgatgatg gtggtttgct 3665221 gatgaaacat gttgtcgaac agctttttcg aatcagccat ctcactttgc tgctgttgag 3665281 gcgttaatcc gttcagctca aggtggtcaa tcgtatggct ttcaatcgat atgccgtgct 3665341 gtgccatttc cttcatttgt tcctctgtca gatggtgctt atgtccgatc gatttgccga 3665401 tcataaaaat cgttgccttc atcccgtact ttttcagcac cggatacgca tcttgataat 3665461 tgtcggtgta cccgtcatca aatgtgatca gcacgcactt ctcactcggt tttttatcct 3665521 gcgtcagcat gagagatgcc tctttcggcg ttaatgtctg atagccgtta tcatgaagcc 3665581 acttcatatg cgcctcgaat tctttctttg gcacacggag gctgtttcct gaagaaatgc 3665641 tgtggtacat caaaatcggc agctttgccg gtttctctgt tttgatccat gcggatgtat 3665701 cgtcttcttt tttctgaact tgtactgcct ttttttccgg tttcttttgt tccgcttttg 3665761 gcatcggctg ctctgcattc gcctcttgat cagcacaagc cgcaagagcc aaacagctgc 3665821 ccaaaagaaa gatgcttaaa aacaatcgtt tcatcgttct cctgctttct gtctatttct 3665881 tcctcctttt tcatcggttt gattctgaga ttttcaatag caaaaaaccg gacatgtctc 3665941 catgtccggt ttttttgatc ttatcggatt ctcacttctg tctcactgtc aaagaaatgg 3666001 cctttattca tatcaaatgc aaccgtcagc tcatcgcccg attgaatatc gaggcgggcg 3666061 tcgatccgcg caataaagtc ttggttgtct atctgcgaat aaatcataat ttcagaaccg 3666121 agcagctctg caacattaat tttcgcctta atcgaagagt tcttatatga ttccacgaca 3666181 atcaattcat catgtatatc ctcaggacgg atgccgaaga tgacctcttt gccgatgtag 3666241 cctttttcac gcagcacttt catttttcct tccgggacgg ttaatgccgc agaaccgatt 3666301 ttgattaagc catccgtgag ctttcctttg aaaaaattca tcgccggtga tccgataaac 3666361 ccgccgacaa agacgttttc agggaattca tatacatcct tcggcgtccc gatctgctga 3666421 attttcccat ctttcatgac tacaatccgt gtcgccattg tcagcgcttc tgtctggtca 3666481 tgcgtcacat aaatcgttgt agtctgcaat ctctggtgga gcttaatgat ttccgcccgc 3666541 atttgcaccc tcagcttcgc gtccaggttt gacaaaggct catccatcag gaacaccttt 3666601 gcatcccgca cgattgcccg gcccagcgca acccgctgtc tctgtccgcc tgacagcgct 3666661 ttcggtttac ggtgcaaata ttcctcaagc ccgagaattt tagcggcttc ttcgactctt 3666721 tttttgattt caggcttcgg cattttccga agcttgagcc cgaacgcgat attatcgtag 3666781 accgtcatat gcggataaag cgcgtagttc tgaaatacca tcgcgatatc cctgtccttt 3666841 ggcgctacat cattgacccg ttttccttca atataaaaat cacctttcga aatttcttca 3666901 agtcctgcga ccattcgcag cgtcgttgat ttcccgcagc cggacgggcc gacgaatacg 3666961 ataaattcct tatcggcaat atgaaggtta aagtcatcaa ccgccggttc cttctgatca 3667021 taaaatttat aaatgtgctc catccgcaat tcagccatct aacatccccc tttgttattg 3667081 taaacgcttt cttatattga gtgtaacagc aattccctct cgctaaaatg ggcagcgttc 3667141 ataaaatcac ccagccattt ttcgtgcata tttccaattt attctgaact ttcattttgc 3667201 aggcagataa aataggcaag aagcgcgcct ttgtacgatt tgatatctat ccctgaccgc 3667261 tcaataaatt tatcaatccg atattgcagg ctgttgcgat gcagatgcag ctttttcgct 3667321 gttaatgtga cgtttgagtt gttttcaata aacagcttaa tggtcttcct tagctcagat 3667381 tcacttccaa ataaaagctc agcttcttca gagagcagtg tttccagttt ttctttttct 3667441 gtttctaata atagaaaagg aaagatcatc tcaaaggtca cactctgcac ctgaggcagc 3667501 cgtttttcag caaacaggaa atacgcctgt tcacgagcgt aatgttttcg cagacactca 3667561 tccggctcgt aaaatcttcc ggcgtaaaaa cggacactga agtagaaatc actttcaaga 3667621 accttagcga gcgattccag ttcgtccttc tccgccgccg cttcactttc ctgctcgaca 3667681 atcacacctc tgtcctcatg gatccacaca atcacaaaag acaccggcca aaaatggcga 3667741 accgcttccg taaaggacgt cctttctatt ttgccgaata aatgaaagtg aacaaatctc 3667801 gtccgtttct ttatatacgc cggcaattcc cctctggaaa aaaggaacga aaaccacttg 3667861 ttttcctcag gtgatttcat agacagttga ttgccctcat ccgcaggcgt caaaaatgac 3667921 tgcagcacca atacttcttt ttcactgatc tctgttttcg gaatggagat atatctctga 3667981 ttgctctcat caaaaaaaca tagacagcct tcccttatgc aaagctcctc agacacaatc 3668041 gaaccgggat aaatagccag cagcgatttc atagagtctc ctctcttatg taaggatctg 3668101 tatattcagt ataaggcgaa acacacatgt tctccactaa aaaagagtat atccggtata 3668161 gatagacgag aaactgaaag ggaaacctca ttcgtttaca tattggcttc agcggaaata 3668221 gaagaagaca tgcaggacca aaggagggtc atcttatgag tttcgaaacg ttaaacaaaa 3668281 gttttatcaa cggaaaatgg actgggggag aaagcggacg tacggaggac attttgaatc 3668341 cgtatgacca gtctgtgatc acaacagcat ctttggcaac gggcaaacag cttgaggatg 3668401 cgtttgacat tgcacagaaa gcccaaaaag agtgggccaa gagcacgacg gaagaccgaa 3668461 aagccgtgct gcaaaaagcg cgcggctatt tacacgaaaa ccgtgatgac atcattatga 3668521 tgatcgcccg cgaaactggc ggaacgatca ttaaatcaac aatcgagctg gaacaaacga 3668581 ttgcgatttt agatgaagcc atgacgtata ctggtgaatt aggcggcgtc aaagaggtgc 3668641 catccgacat tgaagggaaa accaataaga tttaccgcct tccgctaggt gtcatttcat 3668701 cgatttctcc atttaatttc ccaatgaatc tatccatgag atccattgcg cccgcaattg 3668761 cgctgggtaa cagcgttgtt cacaagcctg atatccaaac tgctatttcc ggcgggacca 3668821 tcattgcgaa agcgtttgaa cacgccggtc ttcctgccgg tgtccttaac gtcatgctga 3668881 cggatgtaaa ggaaatcggg gacggcatgc tcaccaatcc aatcccgaga ttaatcagct 3668941 ttacagggtc aacagcagtc gggcgccaca tcggtgaaat cgccggtcgc gccttcaaac 3669001 gaatggcact tgagctcggc ggcaacaatc catttgccgt tctttcagat gcggatgtcg 3669061 atcgtgctgt ggatgccgcg attttcggaa aatttattca ccagggacaa atctgtatga 3669121 ttatcaacag gatcatcgtt catcaagatg tatacgatga gtttgtagaa aaattcaccg 3669181 cccgtgtcaa acagcttccg tacggcgatc aaaccgatcc gaaaaccgtt gtcggcccgc 3669241 tgatcaacga gcgccaaatc gagaaagcgc tggagatcat tgagcaggca aagacagacg 3669301 gcattgagct tgcggttgaa ggaaaacgcg tcggaaacgt gctgacgccg tacgtctttg 3669361 tcggtgcgga caacaacagc aaaattgccc aaacggagct gtttgcccca atcgcaacca 3669421 ttattaaagc tggcagcgac caggaagcga ttgacatggc aaatgatact gaatacggcc 3669481 tcagctctgc ggttttcact tctgatttag aaaaaggcga aaagttcgcc ctgcaaattg 3669541 acagcggcat gacccatgtc aacgaccagt ccgtcaatga ttcgccgaat attgcctttg 3669601 gcggaaacaa agcaagcggt gtcggccgtt tcggcaatcc gtgggtcgtc gaggaattta 3669661 ccgtgacgaa atggatttcg atacagaagc aataccgcaa atatccgttc taaatgaaaa 3669721 aatccctctg tttcaagtac agagggattt ttctttattt agatatatcc acaaaccctt 3669781 cgccaaacac atcgcgtacg tcatgtacga tcacaaacgc ttttttgtcg cagcttctaa 3669841 tgattttttt cagcatagac agctcctgtt tgttaatgac gatatacaaa atctcttttg 3669901 actggcccgt ataatttccc ttccctgata aaatcgtcac gccccgatcc atcaaggtat 3669961 ttacctgctc tgcaatctca ctcttatttt ctgaaatgac cgtaatggct tttttcgtat 3670021 tcaaaccttc aataatgaag tccatcactt tggtaccgat atacagcatc acgatcgtaa 3670081 acatcatttt ttctgcacca ataataaaat aagagctaaa tactacgatt aaatcaaaaa 3670141 acaagagtgc atagctgata ttccagtcta aatatttatt agcaattctg gccagaatcg 3670201 cggaaccggc cgtcgtcccg ccgacccgga taatcatgcc gatcccgact ccggcaaata 3670261 cacctgcgaa aatcgtatta atgatcaatt catcagacgg aatgctccac ccatgtgtca 3670321 gatgaagaaa aagcgaattt gccgcaaccg caatgatcgt ataaaccgtt gtttttccat 3670381 caagaaactt gtagccgatt aaaagcaaaa acgcatttaa gataaagttc gtgacaccag 3670441 gagaccattg aaacagataa tacaaaatca gcgtaatccc agtgactccg ccttccccaa 3670501 gatcattggg aatcgcaaat aaattaaccg caagcgcgaa gaaaaaagcg ccaatcacaa 3670561 gcataagtac atccagcatt ctctttttca tcacgaaaac actccttttc attgttctgt 3670621 tctagcaaat aaaaaaaccc aggagaacgc tctcgaaaaa gagcagaaac tcctgggctt 3670681 ttatcccacc gtgtcataac agccaagctg ctatgtgttt tctctcggtc acagtccaat 3670741 ttgcattgcg gaaccctaga aaaccactgt ttttatcata tccttttcac tttccaatat 3670801 tagcattata agggacggtt cgaattggtt caaggggtat ttgcggagtt ttcatcagat 3670861 aagctggaaa aaaatacgat ttatctatta aaaaagaaca gatataaccg ataagaaaaa 3670921 aagcatatat tttacaagcg aatgtaacta taaatgataa taattataag aaattcataa 3670981 ttttatattg actaagagaa ataatatagg cattatagta catatgtttc gtacatttta 3671041 ttacatagga ggaaatataa tggcaggaaa actagtaccc tgtaaagctt gcggtcaaga 3671101 aattgcaaag ggtgtaaaaa aatgtcctaa ctgcggtaag gatcaacgta acttttttat 3671161 gcgacataaa atcattacgt ttattctcgc agttgttgtc atcattatta tcggtaatat 3671221 gattggcggc ggaggcggct cagaagccac ttccaaaaca tcaagcagca gcaaagcaga 3671281 aactgaaaaa acatacaata tcggtgatac cgtaaaaact gaaaaaactg aagtgacggt 3671341 tacgaaggta gaggacagag atactgtcgg tactcaatat gttgaaaaga aagcatctga 3671401 gggaggtaca attgtagctg ttcaatatac aattaaaaac gtatctaaaa agccgattag 3671461 ctctttttca attccaactg ttaaattagt tgatgctgat ggtacttctt atgattctga 3671521 tattgatgct tctgtaaact atgcaactga gacaaaagtt gataactcta aaattttgag 3671581 tgatctaaat cctaatatta aagtaacagg tgtaaaagca tttgaagttg acaaggaagc 3671641 ttatgcaaaa ggcacttgga aactaaaatt cagtaatgat gttattgtga aaatcaaata 3671701 acagctaaca agggtgcctg tttaggcacc cttgttcttt aaaaaaggcc ttctcaattg 3671761 agaaggcctc cattcttatt ccgcactctt atacccattc acattagaag actgccatct 3671821 ccaggaatca gcacacattt cctcaaggcc gcgtttcgct tcccagccta gttctcgctt 3671881 ggctttcgca ggatctgcaa agcatgtggc gatgtctccc ggacggcggt ccgcaaaacg 3671941 gtatggaacc tctttccctg acactttttc aaaggctttg accatttcca gcacgctgta 3672001 gcctgtgcct gttccaaggt tgtatgcatc ggctcctgta gagttcaata ctttttccag 3672061 cgccttgacg tggccttctg cgagatcaac gacgtgaata taatcgcgta cgcctgtccc 3672121 gtcttttgtc ggatagtcat ttccgaatac gcttaattgc tcgagcttcc cgactgctac 3672181 ctgtgccaca tacggcataa ggttatttgg gattccgttc gggtcttcac cgatccgtcc 3672241 gcttggatgc gcgccgaacg ggttaaagta acgaagcagc gcaacgctcc actcattgtc 3672301 ggctgtatgc aaatcacgca atatttgttc aagcatgagc ttcgtctgcc cataaggatt 3672361 tgtcgcgcct aatggaaagt cttccgtaat cggcgatgtt tccggaacgc cgtatactgt 3672421 cgcagatgaa ctgaatacga ttttcttgac gccgtatttc tccatggcct cgcataaaat 3672481 aaacgttcct gtcaaattgt tatgataata tttgagggga atcgccacag attcgccgac 3672541 tgcttttaac cctgcaaaat gaatcacagc ttcgatttca ttttcagcaa aaacggaatc 3672601 taccgcttcc cggtccaata aatccgcttc gtagaacgtt aaatcttttc ctgtaatctc 3672661 cttgacacgg ttcagcgctt cagctgaact gttggacaga ttatcaagaa caacaatctc 3672721 gtagccgctg ttcaatagtt caacacatgt gtggctgcca atgtaaccgg caccgccagt 3672781 aacaagtatt gccatgatgt aaaccctcct aaaaaatgac ctgttttcat tatatagtgt 3672841 ttagaaccgg tccacatcca tttttaagaa gtttaatcgt ttattaatag ttttttcata 3672901 ttttttagct taaacccttg ccagcaattc gatagaggtt tcagcaagaa tgtgctcttt 3672961 catttcttga tagagctcat tcaagtaaaa gcccggctga agattcagct cagcatctaa 3673021 agcatagacc gtcaatgtat acgcatgatc cttgtcaggc ggtgtcggcc cgcaatactg 3673081 gtgaatcacc tttggatcgt tgcttcccgc aagcggtgaa gcaaagctgt tttgcccttg 3673141 tatcatcaag tcctgtcttt cctcactcgc atgttcagga agctctccga tgtaagccgg 3673201 aatattagcc gctgtccagt gaatccagct gaatccgcat acgggaatgg cgtcatgatc 3673261 gatgaaagta agtgcgagcg tctttgctcc ggacgggatg tcatcaaaat gaattggaaa 3673321 ggatacaaat gggtttcctt ctctcttata tttttcatcc gcgtattttg aatacttgtc 3673381 atgtaaatat ggatttgctt ctacgtatat gttcatatga atccctctct ctattttctc 3673441 gttctatagg tatactaaac gaatcgatgt ataatcagtg ataaacaaat acgcatgtaa 3673501 acgtaacaat ttgttatgga taacttgcag tgaaggagat atttcatgga tttaaaatgg 3673561 ctgcaaacct ttattgccgc agcggaatca gagagcttca gggaggcggc tgagcatctg 3673621 tatctcacac agcctgccgt ttctcagcat atgaggaaat tggaagatga actggacatg 3673681 aggttgtttt tgcatagcgg aagacgagtc gtactgactg acgaaggcag gctctttttg 3673741 ccttatgcca aagaaatgat ccatgtttac caagctggaa agcagaaagt cagtcaatgg 3673801 aaacaggggt acagccgatc actcacgctg gccgtacacc cctacattgc gtcctatatc 3673861 ttgcctcgct ttctgccagc ctatatccaa aaacatccgc atgtcgagct ttcaactcat 3673921 gtggctggat ctgacgctat taaacaagcg gtggaacaca atgaagctga tattggtttg 3673981 tcgcggaaag acccgaacac caacactctt tattatcagc atatatgcga aggtacgctt 3674041 tgtctggcgg ctcctttcca agaaagcaga ccggatgctg catccgtctt aacccgctat 3674101 cggctgctaa cgcatgatca tccgtcatat ggggatgcct ttttagataa catccgatca 3674161 cattacccgt atcttcaaat gatggctgtc gggcagacgg atacggctgt ccacatgatg 3674221 aaagcgggaa tgggggcatc tttcctccct acctacatta tcaaacagga agaagccgaa 3674281 aaaaagctga tggctgtcag cacgcctgca catctagaat tgcctgcgtc ccaaacgttt 3674341 atgatgtgga aaagaaacag cgaagacatt cagcattttc acgccatgtt acatgacttt 3674401 atgcagcgcg aacaagtata gagctgaaaa atcaatctgc cggttgacgt ttttctttcc 3674461 tattttcgct atgcttaatg cagaaaggat ttgatgacat ggcgatgagc ccttatattt 3674521 ttattgtatt gattcttatt attttatcga tgtatcgaga aagaacggta aagcccggga 3674581 agttgctgat cattccactg ttgctcttat ggggcgtatc tgcatcgttt cagccggcgt 3674641 attttcattc cgtattacat gtggcgatca gcggcatttt attactgatc gggctggcct 3674701 gcgggtttgg cattgggaag atggtaaatg tacggattca cccggaaacc ggaaaggtca 3674761 cttcacgcgg ctcacttggg agtgttatcc tcattctagt gatactttct ttgcgcatgg 3674821 ccgcgagaac atggctgcct gagagcaacg agatgtttat tgccattatt cattctatgt 3674881 tcttcgttcc cctcggcacc atcacagccc gcaacatcat gctttacaaa gcatacagac 3674941 gactgaccgc tggcaaagta tccattcaat aaccgaaaga aggaccagca tgaacggaca 3675001 aactccggct cggcactact acaagaagct tgtgccgagc cttattctca ttttgaattg 3675061 catacaattt ttatctcatc caactaaggc tgatcccatt ttgttagcat ttgtatttgc 3675121 ggtatactta gcattcattt ggatcattcc ctatgtggca tccactgctg ttagtttgag 3675181 catattcatc ggactctggc tcctgaccga tttcttttgg gctgtttccg gccaagagca 3675241 gggtgccgcc tattttttga ttgtattttt aatgatatat gccgccttta gactcccttc 3675301 acggctatcc ttgatcttca cagcatgttt aattggaggc aacatattac tcctatcctc 3675361 acaaggggga agcttgaata ccatcatcag caacatctcg atcatgctcg gtctgtacgt 3675421 cctcttctcc tccatgcgtt tcagacgaga agcgagaagg gaggctgaac ggaatcatgc 3675481 tgaattggca aaaatgcatg tgcagctgga gcatgctcat aaagaactcc agaaagcgca 3675541 tgcagagctg caggaggctt ctgttctttc attaaggtac gcggtccttg aggaacgtac 3675601 aagaattgcc cgcgacattc atgacagcat cggtcacgag ctgacttctg tgattgttca 3675661 gcttcaatcc cttccctata tccttaaaag cagcaaggag gattcagaaa aagtcattca 3675721 aaatgtactg agtgtcgcca gggagtgtct tcaagaagtg cggtctgttg ttcaccaaat 3675781 gggccgtagt gaatcgatgg tggggcttac cgctttgcgg gggctcattc atcaagtgga 3675841 ggaacggagc ggcttgcacg tttctttaga tactgccgga ctgtcagaag agtcttggcc 3675901 tccaaacgtg agcgaaacga tctaccgcat cttgcaggaa gcgctgacca atatcattcg 3675961 tcacgctgac gcttctcatg cggcggccgt catttctaat gacaagtccc atctctatgt 3676021 cacaatcacc gacgacggac aattcaccgg cagccttact tatggatttg gcctgacagg 3676081 aatgaaagag cgcgcagaaa aagcaggcgg ttcccttact ttcagtgccg tacagccgag 3676141 cggcctgaaa attgagctgt cattgccgct catgacaacg aataaggagc aaaaagatga 3676201 acaaagataa aatacgcgta gcgcttgccg atgatcagcc gcttgtgcgt gaaggcttcc 3676261 gctacgtcat caacgcacag acggatatga cggtttctgg cgaggccggc gacggtcacg 3676321 atattatagc actcgcaaaa caaacaaaac ccgatgtcat cctcatggat gtccagatgc 3676381 cgcgttgctc aggcatcgaa gcggcgaaag acattatgtc cgcacttcca aatacaaaga 3676441 tagtcatttt aaccaccttt gacacggaag aatacgtatt tgaaggcatc cgtgcgggcg 3676501 cagtcggcta tctgctgaag gatacacttc ctgaggagtt gatagatgcg attcgcgctg 3676561 cggccagagg cgaggcgatt ttccgtacag tcacagctgc taaaatcatc agtgagacat 3676621 ttcgggcgaa acagcaaact catgccgaag aactggcaga gccgttcacc aaaagagagc 3676681 ttgaggttct tcagcaaatg gcctacggac tgagaaatga ggatattgct gaaaagcttt 3676741 tcgtcagtga aagcactgtg aaaacccacg tgcaccgcat cctgcaaaaa tgcaatgccc 3676801 aagaccggac acaggcagtc gtttttgcca ttcgaaacgg tattgtgcaa tagaaatctc 3676861 tcatcccgcc atgctaaaat aagacaaagg agatgattgg aaatgaaaga agaaatcatt 3676921 gaacggttta ctacatatgt aaaagtcgat acacagtccg atgaatccgt tgacacttgt 3676981 ccttccacac ccggccaatt gacattagga aacatgctag ttgatgaatt gaagtccatc 3677041 ggcatgcagg atgcagccat tgatgaaaac ggctatgtca tggcaactct tccctccaat 3677101 actgaaaaag acgtgccgac aatcggcttt ctcgctcacg tcgacaccgc tacagacttt 3677161 accggcaaaa atgtgaatcc gcaaatcatc gaaagctatg atggaaaaga catcgttctt 3677221 aacgaacagc tgcaggtcac cctgtcacct gatcaattcc ctgagctgtc cggctataag 3677281 ggccatacac tcatcaccac agacggcacc acccttctcg gcgcagacaa taaggccggt 3677341 atcgctgaaa tcatgacagc catggattac ctcatcaaac accctgaaat caagcacggc 3677401 acaatcagag tcgcctttac gcctgatgaa gaaatcggaa gagggccgca caaatttgat 3677461 gtgaaacggt tcaatgcatc ctttgcctac acggttgacg gcgggccgct cggcgagctt 3677521 gaatatgaaa gcttcaatgc cgctgccgca aaaattacga ttaaaggcaa caacgtacat 3677581 cccggaacag ctaaaggaaa aatgatcaac tctgcgaaaa tcgcgatgaa gctgaacagc 3677641 ctgctgccgg cagacgaagc gcctgaatat acggaaggtt atgaaggctt ctaccacctg 3677701 ctgtcgattc aaggagacgt agaggaaaca aagctccact acattatcag agactttgac 3677761 aaagagaatt tccaaaacag aaaagaaaca atgaagcgtg ccgttgaaga acttcaaaac 3677821 gaatacgggc aagaccggat tctgctggat atgaacgacc aatactacaa catgagagag 3677881 aaaattgaac ctgtcatcga aatcgtcaac attgccaagc aagcgatgga aaacctcggc 3677941 atcgaaccga agatttcccc catccgcggc ggaaccgacg gatcacagct gtcctacatg 3678001 gggcttccga cgccaaacat ctttacaggc ggggaaaact tccacggcaa atttgaatac 3678061 atctcagttg acaacatggt caaagccgta aatgtcatcg ttgagattgc aaagcagttt 3678121 gaagcgcaag cataacgcca aaagccagtc caaaaaagga ctggcttttt tgtgtgaaaa 3678181 tgaaacattt taaacacgtc ctccgtaaaa caagtatcaa caaatgagga ggaaaaacaa 3678241 tgacaaaaca tgcaatcgct gccaagagtc tcttgaaaaa atggatcatt tccaggccgc 3678301 ttaacatgaa aaagaaatcc agcccatttc aaaaaatcag aaaaatgttc aaacgcttct 3678361 tcaaataaaa catcaaatcc cctaaataca atccgtattc acccgtaccg cccaaatgct 3678421 ccgtaatttg ggttttttgt gttcaattcc gcaaaatagg gtataaacca aacaagcaag 3678481 aaaacagcac ccaaaaacag gtaattcgaa ttacgtaaac ttaggttaaa agttatataa 3678541 aggaatttat tttatcgtcg atagtaacta tagaaccaat catcaacaag agcaaacagc 3678601 gtaattcaag actattttca ggtcatcagg taatactgtt ttagagggac agtttcttgt 3678661 tatttattga tttagaattt tttgaatact ttttggcatt ttatccgtac aatagagagt 3678721 accaaaactt tttttgggag gtatgtaata tgatcctatt tattatcatc gcattatgcg 3678781 gctatcttct tttttctttc agcaaggaca atcgccgcaa accgcaaaag acaagccctc 3678841 tgccagcagc cgcacctcat cacaacaacc taatcgacct tgacgccatc cgccaaaaac 3678901 gccggatgca tctttcctaa ttctatattt caaacgaaaa ggctgctgaa tcacgcagcc 3678961 ttttaaaatt gttttgattt agagcctgaa accttttcgc cacctatccg taatttcata 3679021 caaggcaaac ccaaaggaga cttcagcaat gatcgagtta tttatgaaac aaaaaatgtt 3679081 ctcatttaaa gatgcatttc acatttatga ccgggatgaa caagaaacat tcaaggtgga 3679141 ggggcgtttt ttctcgttag gagactcatt acaaatgaca gactcatctg ggaaaacgct 3679201 cgtttccata gaacaaaaac taatgtcttt attgccgcgc tatgagattt caattggcgg 3679261 gaaaacagtt tgtgaggtaa cgaagaaagt aacgttttcc aaaccgaaat ttgtgatttc 3679321 cgggcttaac tgggaaatag atggtgattt atggagggat gaattccaac tgacggacgg 3679381 ggaaaatgtc cggatgtcag tgagcaaaaa gtggctcagt tggggtgatt cctatcactt 3679441 gcagattgca tacgaggaag atgttctgat ttgcactgcc atcgctatcg tgcttgatat 3679501 ggttttatat aacgatgaag atgaaagtat tttctaaaaa gcattgacaa ttgatccaaa 3679561 agtaataata ttaagataat tgaaatctga atatgaagtt gtaccttatc aagagaggtg 3679621 gagggactgg ccctatgata cccggcaacc gctgtttcaa acagaatggt gctaaatcct 3679681 taagaacatt gcgttcttgc agatgaggcg gagatttgat cgttcaagct cttccttaca 3679741 caaaggaaga gctttttaca tgcttaatat ttcagaaaag aggcgaataa catggctcaa 3679801 caaacgaatg ttgcaggaca aaaaacagaa aaacaacgca aagcaccttt ccgcgccgat 3679861 catgtcggca gcttgcttcg ttccgttccg gtaaaggaag cccggcaaaa aaaagcggct 3679921 ggtgagatga cagcggaaca gcttcgtgat atcgaaaatc aagagatcac ccgcatcgtg 3679981 gaaaaacaaa aagaaatcgg tctcgatgtg gtaacagacg gggaattccg gcgttcctgg 3680041 tggcattatg acttcctgga agggcttgac ggtgtggaac cgttcatccc ggctgagggg 3680101 attcagttcc ataacacaaa aacgaaagcg cgcagcatca aagtgacggg aaaactcgat 3680161 tttacgagcc acccagcgct cggtgattat caatttttac atgagattgc cggtaacgcg 3680221 acgccaaaat tgaccattcc cagtccaaat atgctgtttt ttggcgaaaa ggcggataaa 3680281 gggatttatg acgatcaaga ggaatacttt catgatatgg cccaagcgta caaaaaagca 3680341 atcaaagcct tctatgatgc tggctgccgt tatctccagc ttgatgatac gtcatggtct 3680401 ctcttctttg aggacaaagg cagagaggtt gtccgggcgc tcggcggtga tccagaaaca 3680461 ttgccagcca tatttgccaa aacaattaac gatgccgtcg cagaccggcc tgacgattta 3680521 acgatcacaa tgcacatttg ccgcggcaac ttccgctcaa cctgggcggc atcaggaggg 3680581 tacgacgctg tagcggaaac gattttggac ggcttaaacc ttgacggcct tttcttggaa 3680641 tacgatgatg accgctccgg aaactttgat ccgctccgtt ttgtgaagcg caaggatctg 3680701 caaattgtgc tcggcttgat cacatcgaaa tacggcgagc ttgaaaatcc tgaggatgtg 3680761 aaacgccgta tcaatgaagc cgcgcgtttt gtcagcttgg accagctatg cctgagcccg 3680821 cagtgcggtt tcgcctctac agaagaaggc aaccttctga cagaggagca gcaatgggca 3680881 aagctgcgcc atgtcatcga cattgccaac gatgtgtgga gataatctat cattgacaga 3680941 aatagaaaat gtgtgaataa tagatactat cagaaaattt aataaaaagg ttttccttat 3681001 caagagaggt ggagggactg gccctgcgat acccggcaac cgctgtttaa cagaatggtg 3681061 ctaaatcctt tagagcaatg attgctcttg aagataaggt tgagattgtc acgcaagctc 3681121 ttccttatcc aaaggaagag cttttttata tttgaatgga aagaaggaat ggacaacatg 3681181 tcacaacaaa caacacccgc agaacaaaaa tcacttcaaa gaaaaaaacc gccgtttcgc 3681241 gcggatcaag tcggaagcct gctaagatct gagcccgtca aaaaagcgcg gctgcaaaaa 3681301 gcggccggcg aaatgaccgc tgagcagctt cgccaaattg aaaacgacga aatcatccgc 3681361 attgtggaaa aacagaagga aaccggcctg aacgtcgtga cagacggtga attccgcaga 3681421 gcatggtggc actttgattt cctggaaaac ttagatggcg ttgagccgtt tactcctgag 3681481 caaggcattc aattccataa cgtacagaca aaagcacgcg gcattaaagt cacaggcgat 3681541 atcgactttt caactcaccc aatgcttgaa gattactcat ttctccatag cattgccggt 3681601 gacgcgacgc caaagatgac gattccaagt ccgaatatgc tgtttttccg cggaaaactg 3681661 gaaaaggatg aatacaaaaa cgattatcaa cttttccagc acgatgtatc caaagcatat 3681721 aaaaaagcga ttcaagcgtt ttatgacaga ggctgccgct acctccagct tgatgataca 3681781 gcgtgggccg ttttcttatc agaaaaaggc ttaaaacaaa tcgaagcgtt cggaacaacg 3681841 cctgacgagc ttcgccagct gtttgcgaaa tccattaacg acgcgattgc agaccgcccg 3681901 gatgacttga cggtaaccat gcatatttgc cgcggcaact tccagtccac ttggacagcg 3681961 gaaggcggct atgacgcagc agccgaaacc atttttgacg gcttgaatct tgacggactt 3682021 ttcttagagt atgatgattc acgctcaggc ggatttgagc cgctccgtta cgtaaaacgg 3682081 tctgatcttc agcttgttct tggcttagtg acatctaaat tcggtgagct tgaaaatccg 3682141 gatgacgtga aacgccgtat cgaagaagcg tcccgttatg taagcttaga ccagctttgc 3682201 ctcagccctc aatgcggatt cgcttcaact gaggaaggca acaagctgac tgaagaacag 3682261 caatgggcga agctccgcca tgtggttgag atcgctaatg atgtttggaa ataagcaaag 3682321 aaaaaaacac acttgattcc ctagcggagc aagtgtgttt tttatgtcat tgtgcggtgt 3682381 agcccccatc aaggacgaca gcctgcccag tgacgccctt cgccttctcg cttgccaaaa 3682441 acacggcata atccgcaatt tccttgacgg aaagcagtcg cttttgcggc acaagcggaa 3682501 aaatgacttg ttcaagtaca gagtcgtaag ggacatttct agttttcgat agatcgctaa 3682561 gctgattgcg tacaagctgg gtatcgacat aacccggaca gagcgcattg actgttatgc 3682621 cgtggggcgc gccttccagc gcccctactt ttgtgagtcc aatgacgccg tgcttggcgc 3682681 tattataagc ggatttccct gcaaagccca ctaatccatt aacagacgca atattaatga 3682741 ttctgccaaa ctgctgtttt ttcatgatcg gaaaaacatg cttcattgca ataaagggag 3682801 ccgtcagcat gaccttgatc agctgttcaa aggtgtctgt cggaaactct tcaatcggag 3682861 cgacgtgctg aataccggca ttgttcacca gaatatccaa gcggccgtat tgtttttgga 3682921 tgacgttcac cgtatcagca acttgcgctt cctttgtcac atcatacgga atggccgccg 3682981 cgtcaaagcc ttcttctgca agcttggagg ctgctttttc acatgcttcc ggacggaggt 3683041 ctgaaacgat gacgctggca ccttcccggg cgaattctct tgcgatttcg aatccgattc 3683101 cgccggcagc ccctgtcacc aaagcgactt gttttctcat gtcaaacacc ttcccattaa 3683161 gaattgagta cagactggct tacagcgaaa tcagcttctg ttttttcata aacctcttca 3683221 attgtgacac catcctgaag ctccgtcagt gtcatgcggc cgttcacaaa atcaaataca 3683281 gccaaatccg taatcagcct gtgtacgact ttctggcctg tcagcggaag ggagcatgtt 3683341 tttttcacct ttgattcacc atgcttattg acgtgctcca tgatgacaac gattcgtttc 3683401 gccccgttga cgagatccat ggcgccgccc atccctttta ccattttgcc cgggatcatc 3683461 caattggcca aatccccctg ctccgaaacc tccattccgc cgagaatagc taaatcgata 3683521 tgcccgcctc ttatcatcgc gaatgactca gcgctgtcaa aataagaggc gcctgtcact 3683581 tcagtgatcg tttcctttcc cgcattgatc aaatccgcgt cttccgttcc ttccagagga 3683641 taggggccaa ttccgagcaa gccgttttcc gactgaagca tgacgtgaac gccatcgggt 3683701 atctcatttg cgacaagcgt cggcattcca atcccgagat tcacattcat gccgtccttg 3683761 atttcttgta cagcccgttt gaccattcgt tttctcgctt ccttcacttg gcctcaccct 3683821 ttcccgatgc ttgctgaact gttcgttttt caatccgttt ttcttggctc gcgccaagca 3683881 cgacatgctg tacgtaaatt cccggcgtat ggatgtgatc tggatcgagc tctcctgctt 3683941 ccacgatttc ttccgcctcg gcaatcgtga tcttgcctgc catggcggca atgggattga 3684001 aatttctcgc cgttttccta aaaatcaaat tgcccatggt gtccgctttc cacgctttga 3684061 cgatcgccac atcgccggta atgcctcgct ccagcacata agtccggccg ccgaatgttt 3684121 tatgttcttt tccctcggct atggaggtgc cgacgcctgt cgccgtataa aatcccggta 3684181 tgcctgcacc gcctgcacga attctctcag cgagcgttcc ttggggaaca agctctacct 3684241 caagctctcc gcttaaaaac tgccgctcaa aaattttatt ttcaccgaca taggaagcga 3684301 tcattttctt gatttgcttg ttagccagaa gcaaaccaag cccccagtca tcgactccgc 3684361 agttattgct gacaacggtt aaatccttta ctccctgatc tcttatagac aaaatgagct 3684421 gttcagggat gccgcacagc ccaaaccctc ccgcgatcag cgtatcccca tcatgaatca 3684481 gtttcgcagc ttccttgctt gatgacagca cttttcccat attgatgccc ctttcgtttt 3684541 cttctacact agaccagtca ggctgtaaat cgcgatcaca gcaaatacgg cagccgtttt 3684601 aatgagcgtg atcgcaaaaa tatcgcgata ggattgccgg tgggtcaaac ccgtcacggc 3684661 cagaagcgtg ataacggcgc cattatgcgg cagtgtatcc atcccgcctg atgccattga 3684721 aatgacccga tgcatcacct ctggcggaat attgtaagcc tgaatcgcct gtaagtattg 3684781 ttctgacatc gcgcttaacg caatgcccat tcctcccgaa gccgagccgg tgattcccgc 3684841 cagcgcagtt gtcgtaacgg cgccatttac aagcggatcg gtaaaagtat gtgaaattcc 3684901 gctgctcagc ttatgaaacc ccggcagcgc ggcgataatg ccgccgaacc cgtactcagc 3684961 acccgtattc atagatgcca gcaaggcgcc gccaattcct tcattcagcc cttccttcaa 3685021 ttgggcaaac acacttctcc aatcaaataa tatcgttgtg atgatgccaa tcactaaagc 3685081 aatctccacc gaccaaatag cagccgctga agaaatatca agcctgccga actcctttaa 3685141 tcctatggaa gaaaaatcaa atccattcgg ataccacttt ggcaggtaaa tggtgaaata 3685201 tttattcact gcaccgacga gaataagcgg gacaaaggca agcgcgtgcc gaatcgggct 3685261 tttgtccggt tcagccgcgg actcaatcga ttcaggagca ggagcattct gcgaatcaaa 3685321 accgccatag ccttcgccag atgcctgcgc tttcttccgc cttgattcca aatagagcat 3685381 cccagctgcc agcacaatca ctgcgcccat caaacccagc caaggggcgg cataaatgtc 3685441 tgttttgaaa aacgacgtcg ggatgacatt ttggatttgc ggcgttcccg gaagtgcgtc 3685501 catcgtaaac gtaaaagctc ctaaagcaat cgtacccggg atgaggcgtt ttggtatgtt 3685561 tgcttcttgg aacatgtttt tcgcaaaagg atatacagca aatacgacaa caaacaggct 3685621 gacaccgctg tacgtcaaga cagcacccat cagcacaatg gcaagtatcg ctctttttgc 3685681 cccgacaagc cggacaattg ttttcgcgat tgatgccgca agcccggcca tttcaacgac 3685741 ctttccaaaa atagcaccga gcaaaaacac tgggaaatac agcttaataa aacccgccat 3685801 cttctccata aaaattgatg aaaaaaaagg aagcacatgg cttggatctg tcagcagcac 3685861 cgcgaataac gcgcaaatcg gcgcaaacaa tatgacagaa aatccccgat acgccgtaaa 3685921 catcagcaaa cctaacgcca atagaatgat gatcagttcc acacacacat cccccgtttc 3685981 cgcgaactag aaagcgttta caaaaacctg tccgcatcgg ctgtttccgt cccctttcca 3686041 tatgtacgag aagcgtgggc caactattcc gattaaaaaa ggaaagctcc ttttttcgga 3686101 gctttcctct accattcatt tcattcctat taggatatca acatcaaccg taatatcggc 3686161 tgatttcatc tctttcagca ggctgactcg atctttcggc gccgaccagg caagcggcgt 3686221 catcttgaga agccagtgga tcgcctgctg gtcaagcgtt ttaacatagc gcagcctgac 3686281 aggacggctg tgtgctgcat ttgctgtaaa acgctcaact gctgccgtat tggaatacgt 3686341 gcgccttggt gaatcagtat ataaaaattg ccttaattct attaaatagt cgcttcgcgg 3686401 cactactttt atgagcatgc catcattctt cagcagtcta tgaaactctg cataattgga 3686461 cggcgaaaaa atagacagaa caacatcaaa ttggcgatca tgaaaaggag cacgcgccac 3686521 atcggcaacc gcccacatca gatctttgaa tgccttagaa gcttttaaga tcccgtcctt 3686581 cgaaagatct atgccggttc ctatcgctgc tttccctgca taatcaaacc cgcaaagcgc 3686641 attcaaatga gaaccctcac cgcaaccgct gtccaagatg gtgaatgcct catgaccaga 3686701 tttgggatga ctgatgagct ctgcaatcgc atcatggagc gggtcaaaaa aaccacattc 3686761 tccaatcagc ctgctcctcg cttcaaaaag ctcggcaccg taactggttt tgaccggctt 3686821 cgtcagaaag ttcacgtagc cgtgccgaga tagatcaaat gtatgtcctc gttctgtaca 3686881 aatcaagctt ttccctgatg ccgcatccat agaagaatcg cagagcgggc atcgaaacat 3686941 gctgaaatca actgttcgct tcatgataaa aaacacccca ttcattcatt tttagataaa 3687001 tgaaaaaggc atagacaaat aaacctaggc ctatctcaaa aattggccag gtctggcagt 3687061 ttgtctacac ctgtcattat ctataacgaa tgaattggat aatcatgaaa aaaactccct 3687121 ttctgctgta tgggtttccc cgtttccatc atacaacaaa tatccaggag ctggaacctt 3687181 atagtgaaga aaaatcagta ctgacatgct ggtatcccgc caacatcata tcagcatagc 3687241 aatccagcat gtttttcctt tattttctca ttttagaata taaattttat tattgtgaaa 3687301 atagttaaaa aggttgattt tcaaaaagtg aaaggataaa atactgctat catcttagaa 3687361 aaagacattc ttgtatatga tcagtaatat ggtctgattg tttctaccta gtaaccgtaa 3687421 aaaactagac tacaagaaag tttgaataaa tttgaacgag ttgaaaagga caagttcttt 3687481 tctgtttgct cttatttttc acactttctg cacttccaga atttgtgaag gataagagct 3687541 ttttttgttt ccataataac cctcatagga gttgctatca tgtacttttt actaaacctt 3687601 gtcggtctca ttgtgattat ggcagttgta ttcctatgtt ctccgcagaa aaagaaaatc 3687661 aagtggcgcc cgatcattac gttaattgtt ctggaattgc tgattacttg gtttatgctg 3687721 ggaacaaaag tcggaagctg ggccatcggt aaaatcggtg atttcttcac ttggctgatt 3687781 gcttgcgcca gtgacggtat cgcgtttgcc tttccgtcag tgatggcgaa tgaaacagta 3687841 gactttttct ttagtgcgct tcttccaatt atctttatcg tcacattctt tgatatttta 3687901 acgtatttcg gcattttgcc ttggctgatt gataaaatcg gatgggtgat ttcaaaggct 3687961 tcccgcttgc cgaaattaga aagctttttc tctattcaaa tgatgttcct tggaaatacc 3688021 gaagcacttg cggtcatccg ccagcagctt acggttttaa gcaacaaccg cctgctcaca 3688081 ttcggtttaa tgagcatgag cagcatcagc ggctccatta tcggatctta tctttcaatg 3688141 gtgcctgcga catacgtgtt tacagccatt cctttgaact gcttaaacgc gctgattatc 3688201 gcaaacctgc tgaatcctgt tcacgtgccg gaggatgaag atatcatcta tacaccgcct 3688261 aaagaagaga agaaagactt tttctctacg atttctaaca gtatgcttgt cggcatgaac 3688321 atggttatcg ttattttggc aatggtgatc ggatatgtcg cattaacgtc agcagttaat 3688381 ggcattcttg gcgttttcgt acatggcctg accatccaga caatttttgc ttatctgttc 3688441 agtccgttcg cattcctgct tggactgcca gtgcacgatg cgatgtatgt tgctcagctg 3688501 atgggcatga aattagcaac gaacgagttt gttgcgatgc ttgacttgaa aaacaatctc 3688561 aaatcccttc cgcctcacac cgttgcggtg gcgacgacat tcctgacgtc ctttgcaaac 3688621 ttcagtactg tcggcatgat ttacggcacg tacaattcga tccttgacgg agaaaagtca 3688681 acggtcatcg ggagaaacgt gtggaaactg ctcgtcagcg gaattgcggt atctttatta 3688741 agtgctgcga ttgtcggcct gtttgtgtgg tagaaacatt gagccatatc ccttttcgga 3688801 tatggctctt ttcattattg ataaatagag gctggcacct gcacatcccg gattcccgct 3688861 gcataaggcc ccaagtcata ctggccgaag acgatggcga tcccgtttgc cgtaaagtaa 3688921 aacattgtgt ctctgtttag ggttatatcc tctttcttta catcagagaa aaacagcaca 3688981 tcgtgttttt tgatatagct atataggtaa tctctcgttt tgctgacttt tgttttggtg 3689041 ttcagaatct gatccagcgt cacccgcttt tgtgctttca agtcatagtt gaaggactgg 3689101 acagacgtta gaccgtgggc gccccctgaa tagatataat tgagtgtttg aatgctgagc 3689161 ttgcctgccg cattgtattt gacgctgaag gatgtttgat attcccgttt taaagccctg 3689221 ctgttcgcct gcttttttgt ttttcaggta ttcctgatac gattgttcat gtaggctttc 3689281 agctcttgat tgattttctt ttcaaacgcg gcattcccga cgtgatgcac ttgtggatac 3689341 gttaactcct tgatcttttt gtacgtatgg gtgctgacag tcggtgtttt cgcttgaact 3689401 gcttttaaag atggggccgc atatgcaaat acagaaaaaa gcaagactgc aatgcccgcg 3689461 gctttcagca tgttattcca tttcatacaa tctactcctt tgatgtcgtt gtttatcatt 3689521 cccttattta agcaatacac acttttatag actgattaaa tcgaaagaag tttctaggtc 3689581 taacagcatg atttttccaa taaaaaaaga gacacaggat gtctcttttt ttactgtttg 3689641 cgcccagaaa tcgcttcatg aagggcttgt gccaaatctg tatttccgaa catctctaat 3689701 accgcaatga cagtctggtc cggaatgtgc tctgcttcgt gttttggcac gaccagatcg 3689761 tccatggttt ttttcaagct ttcattcagc ttttgctgcg gatacgcttt ggcgtacagc 3689821 tccatcggat caagatcatg gttcacgcac cactgggcaa acaccaaaat catcatattt 3689881 tcatcgcgtt cgtaagcttc agtgagctgt ttttcgttca tttgtcatgc tccttatgaa 3689941 aagtatcttc cttaaagata caggagccga tcaaattcgt ctatcccaat ggcgatgagc 3690001 agcaaccgca tcgataaatg ccttgctgaa agcggtgtag tcaggttcat ctttagccgt 3690061 tacgatgcct agcccctctg ttgtcccgac agaggattga agaaggtcaa ttccttcatt 3690121 tgccgcaccg atcgccttgt agtgattgta agcttctctg ataaacgcca tcgcttgttt 3690181 gttgtctttt aactccagtc ctcctgcggc atagacggca tcatacagaa cagaatcaac 3690241 cgtcaggaac gtgccgctgg cctcaagctg ctgtccgctg ccgcttgtca tataccccag 3690301 attttgactg atgatatcca ctgtgattcc ttcttgcttt aaggcttcca gtactgtttg 3690361 cagctctttt tcatgaaatc cgtttccggc gagtacagcg acttttcttg ttgacgcggt 3690421 tttcactgta cgggcttggc ttaacgcagg cgaagtaaga atttctttag atgctttacg 3690481 cttcgcgggc gccgccacgc ctactccttt ggcgatttct tctgctaaat ctgcatcgac 3690541 attgctgaag acatcaacga cctgccgctg tacgtctttg cttttgacct tcccgacctc 3690601 gaagcagaaa gcagaaatga tgtgctgttt ctccacagga gacatgctgt tccagaaaag 3690661 cttcgcctgt gagtaataat cgttgaagct gtcgcttcgc tggcggattt ttttgccctc 3690721 gactttttcc tgatagtgga cgtagccgcc ttcttcagct gtcgcaggcg acggatcatt 3690781 gttttgcagt gagtttttat gataagcgac aggtccctta ttgatcgtca tccggtgata 3690841 gccgtcgtat tggttgttat ggaatggaca gaccggccgg ttaatcggaa tctcatggaa 3690901 gttcgggccg ccaagacgga tgagctgtgt atccgtataa gagaaaagcc gcccctgcaa 3690961 tagcgggtca ttggtaaaat cgatgcccgg cacgacattt cccgggtgga atgcgacttg 3691021 ttctgtttcc gcaaacacat tatcctgatt gcggttcagc gtcatttttc caatgatctt 3691081 caccggcaca agctcttccg gccacagctt agttgggtca agaatatcaa aatcaaactt 3691141 gaattcatct tcctcatcaa tcatctgcac gccgagctcg tattcaacct tgccgccgtt 3691201 ttcaattgtt tcccacaggt cacggcggtg gaaatctgga tctttcccgg caattttttg 3691261 cgcttcatcc catacgagag aatgcacgcc gagcaccggc ttccagtgaa atttcacgaa 3691321 acgtgccttt ccttgttcat tgacaaaacg gaacgtgtga acgccgaagc cttccatcat 3691381 tctgtagctg cgcgggatgc ctctgtcaga catcgtccac atcaccatgt gggcagactc 3691441 agggttattg gcgacaaaat cccaaaatgt atcgtgagca gtcgcagcct gaggcatttc 3691501 attgtgtggc tcaggcttaa acgcgtgaac caaatccgga aatttgattg cgtcctgaat 3691561 gaaaaacacc ggaatgttat ttcccacaag gtcatagttt ccttcttcag tataaaattt 3691621 tgtcgcaaag cctctggcat cccgcaccgt gtctgcggag cctttagaac ccgcaaccgt 3691681 agaaaaacgg acaaataccg gtgtcttcac cgaagggtcc tgaagaaatt tggcccgtgt 3691741 gtattccgtc attggttcgt aaacctgaaa aaagccatgc acgccaaatc cgcgcgcatg 3691801 cacaacgcgc tccggaatcc tctcatggtc aaagtgcgtc attttctccc ggaaatgaaa 3691861 atcctccatc agcgtcgggc cgcgaacccc ggcttttaac gagtgctcat cctctgacac 3691921 tcgcaagcct tggtttgtcg tcattttctt cccgctgtta tcggtcctgt actgctcaag 3691981 ctgctcgtcc tttgagtgtt catttacacg tttgttttgg tcatcactca tgtctgctcc 3692041 ccctttttaa aacgaaacat tctacagcac atttacccgt ggcgttcttc atataaactg 3692101 ctaatccgct cattaggatt tttggtctac atataaatat gcggtcatac acatttgaaa 3692161 taagccttct tcacagaaag aaaggatgga agcgcttacc aaaaaagctg ttgaataggg 3692221 gaggtcatat catgcttgcc atactcggtt ttgtgatgat gattgtcttt atgtacctta 3692281 ttatgtctaa ccggctttcc gctcttattg ctttgattgt cgttcctatt gtgtttgccc 3692341 tgatcagcgg atttggcaaa gatctcggcg agatgatgat tcagggcgtt acagacctcg 3692401 cccctaccgg tatcatgctg ttattcgcca tcctgtattt cggcattatg attgactcag 3692461 gcctgtttga tcctctcatt gccaaaatct tatcgtttgt caaaggagat ccgttaaaaa 3692521 tcgccgtagg cacagcggtt ctgaccatga ccatttcgct ggacggagat gggacaacaa 3692581 cctatatgat taccattgca gcgatgctgc ctctctacaa acggctcggc atgaaccgtt 3692641 tggtgttagc gggaatagcg atgcttggtt cgggggttat gaatattatc ccgtggggcg 3692701 ggccgactgc gagggttttg gcttccttaa aattggacac gtcagaggtc tttacaccgc 3692761 tgattcccgc tatgatcgcc ggcattctct gggtgatcgc cgttgcttat atcctcggaa 3692821 agaaagagcg gaagcggctc ggcgtcattt cgattgatca cgcaccgtct tccgacccgg 3692881 aggccgcacc gctcaagcgt cccgctcttc aatggtttaa cctgctgctg actgtcgctc 3692941 tgatggccgc actgatcacc agcctgctgc cgctccctgt tctttttatg actgcgttcg 3693001 ccgttgcctt gatggttaac tatccaaatg tcaaagagca gcagaaacga atctcggcgc 3693061 atgcgggtaa tgcgttaaac gttgtctcaa tggtgtttgc tgcgggcata ttcacaggca 3693121 ttctctccgg cacaaaaatg gtggatgcca tggcgcattc tctcgtttca ctcatccctg 3693181 atgccatggg cccgcacctg ccgttgatca ctgcgatcgt cagcatgccc ttcacctttt 3693241 tcatgtcgaa tgacgccttt tacttcggtg tccttcccat catcgccgaa gccgcttccg 3693301 cttacggaat agacgccgct gaaatcggga gggcctcctt gctggggcag cctgtgcatc 3693361 tgctcagccc gcttgtgcct tccacctatc tattggtagg aatggcaggc gtcagctttg 3693421 gcgaccatca aaaattcact attaaatggg ccgtgggaac aacgattgtg atgaccattg 3693481 cggcgctttt gattgggatt atttctttct aaatgtatga gcttgatcgt agcattgagt 3693541 gagtacgtga tttacagagg ggagaagatc aaataggata ttatgagtga atagaagatt 3693601 catgccaaca acttctcatt acaatcataa gagcctgcta tattgcagca ggctctttca 3693661 catttggcat tatttttttg tatagcgcac ccagtcataa tgagcgtata gcggatttac 3693721 accattgtag gagccaagcc attcatcgac acccgtgcca ttccacaagt tcatcatgat 3693781 ctttccaggt gttgtcggaa tttggtttgt tgcagtatgt tttaattgcc cgtcgacata 3693841 ccatttaata gagtttggct gccaatcgaa tgcatacgta tgataggcat tggctgcatc 3693901 aaacccgaga tcaacaatct tctcatggtt tcctgcacca tttgtataat agttaaattg 3693961 aaccttcgtt gtgtcttttc ctaaaaattc gatatcaatc tcatcccaag gagttccatc 3694021 tgttggacct gtgtaagtga agaacgatga aacgatccct gtgtttttag ctggtttcat 3694081 tctgacttca taaagtccat agccatatgt ttgaacagaa cggttttccc cgcagtcaaa 3694141 cttgttataa gctgggcttg ttagcgctaa acgcatttca cccaatgacg tcattgatac 3694201 gttattagcc cgccacgtgc agttgaacat atttccattc gaataaccat ctgctttttg 3694261 ccaaaaaccg gagttatagc cgttaaaagg gtcaaaaaac gatccacctg tttgagctga 3694321 ggcagtagca gtgactgcaa acaaactcat aaacaatcca gtgacaagaa gcagcaacac 3694381 tcgtttcaga taaggcatat tggcattccc ctttcattga aagcgttttc tatgttgatc 3694441 ttacatgatt cttttaaaag ggaacatcgg tcaaaataat gataatatcg aatcttacta 3694501 acttgaatcc tgtaactatc atcatcttcc ctctgaaaaa aataaaaacc taaattacca 3694561 tcagcacaga cagagatgat ccgcactcat tgcaatttag gttttgcctg ctttatcagt 3694621 aacaatccta ccattttcat atgtgaatgt aagaaaaagt gaacacaagg aaacacaaat 3694681 gtcagcgctc tcattatgct tgtttaacta ccctttctat gtgaatggtt aaatacagca 3694741 gctcgtcact tgtgagcttg tgctcatact cccgctcaat gtaggtttgg attttcttcg 3694801 tgcattcata cgcgcgatga tacttttctt tcactgtatc cagcaaaaaa tcgtcctggc 3694861 tttccatgtg agtgccgtta aatagacgct gcgcgaaaaa ctttaagtgg gtgacgaacc 3694921 gataatagtg aagcgattct tcgttgaatt caatcttaaa atggtatttt acaatactca 3694981 aaatctcttg catgactttt gtaatgttga taatattggg catctcttca ttcagctcgg 3695041 catttacaat atgcagagca ataaagcctg cttcatcctc tggcagagac acaccagtct 3695101 tgttttttac cataaccaac gcttctttgc cgatcgcaaa ttcgtctttg tagagccgtt 3695161 ttgtttccca cagcaaggcg tttttgatat caagcccttt ctggttgcgc tggatggcaa 3695221 agttaatatg gtcggtcagc gacacataga tgctgtcgtt gagctttttg ccgagctgta 3695281 attttgcgta gctgataatc tcttcggata cttccataca ctcgatcggt atatcataca 3695341 aaagggtttt gaacttttct gatacatcct tgttatcgag cgtgaacact ttctcaatgc 3695401 gggcttcatc gacatcatcg ccggactttt tctgaaacgc gagccccctg cccatgacga 3695461 ccaattcttt cccctgttca ttgaccacgc tgatcacatt attgttgatc accttcgcaa 3695521 ttttcatggc atgtccctcc aaatctacta agaacagact atatcttgat tgtacattct 3695581 ttttgtacta ggtcaatatc atcagggaaa gacggaagct ggtcagtaca attcactccg 3695641 tacctgctgc ccgggctgtt tttgaagcag cgcctccaga tggcgttcaa atgatgcctt 3695701 gtcagctttc tgctttttga caatgctgtt catgatttta atgctttcag cactgtattg 3695761 tgtatattgt tttttcagct gatccagctg ctgtcttgtc ttcttcgcgt ttttcggtgt 3695821 gacttggttg atgagtttga tcatactgtc tgcggtctca aaaaaaccgg ctctattttc 3695881 tgtcagctgc tgaatttcga tgcggctcat atcttgatta cgcgtttttt gaagcaaggc 3695941 aaccgcctcg ctgttttgtt ttttgagcga tttgttctca agcttaatcg attcgagatt 3696001 ctccttcgca atgtctgctt cttcttcagt catgctgatt cgcacgaagt attctggatt 3696061 gccgattcca taatcaaatg cttcgctcac ttgtatcatg gaactgaaca caatggccag 3696121 ctgcctgtcg cttgcgaggg cttggaaatc ctgctttttc ttactgctca tcggtttggc 3696181 tgcggtttgt tttactgtct tttgatcaca gtctgcgaac atctgagcct caccttcact 3696241 ttcgcatgcg ctcatcacaa gaactgtgac cagcaggctt atacacaagc ctattcgcct 3696301 catgctctgt ctcctctctg ctgaatccct tctggaaaat accataaaat atagttaaat 3696361 ggtaccagat gcacctaacc ccagcaataa atcaaaagta tgatttgaag cgaaaaaaca 3696421 taaatatttt gtaaaaattg acgtgcattc cattcttttc aggcccattt ctcgtacaat 3696481 agaagtatcg ttaccggaga ggggctctga tgatgaaacg ttttacgaaa caagaaaaca 3696541 gctgggtgtt atatgactgg gcaaattcag cttactcaat tgtcgtgacc accgcggtat 3696601 ttccgttatt ttataaatca gcagctgcgg aaagcggtgt cagcgccgct caatcgactg 3696661 cctatctggg ctataccatt gcgatttcaa cgtttattct tgcgatgctc ggccctattt 3696721 taggcacaat cgccgactat gaagggtgca agaaaaagtt cttcggtttc tttgtgtcag 3696781 ccggtgtcgc cagcaccgcg atgctcgcct ttatccctag tgaacattgg ctgctattgt 3696841 tgctgtttta tacggtatcg gctatcggtt tttccggcgc caatgtgttt tatgatgcct 3696901 ttctcgtgga cgtcacgcct gagaagcgga tgaatctcgt ctcggcacgg ggttttggct 3696961 taggatacat tggaagcacg attccattta tcatcagtat tgctgtcatc ctgctcgcac 3697021 aagcagagac tattccagtg tctgtatcgg ccgcaagcca gctgtccttc ttcataacgg 3697081 ctgcctggtg ggggctgttc accatcccaa tgattaaaca tgtccatcaa cgctattaca 3697141 tcaaaaaaga acctcatatt gtcatcaaca gctttaagcg gctcggccaa acgatgaaac 3697201 ggatcaggca ataccgggca cttttcctct tcttgctcgc ttatttcttt tatatcgacg 3697261 gagtcggcac gattattacg atgtcgacat cctatggatc agatttaggg atcggctcct 3697321 caagccttct gatcatccta tttgtcaccc aggtagtcgc cgcgccgttt tcgattatat 3697381 acggaaaact ggcagaacgc ttcacgggga agaccatgct gtacgtcggg atcgtcattt 3697441 atatgatcgt ctgcgtgtat gcctatttta tggagacaac gcttgatttc tggatactgg 3697501 ctatgcttgt cgccacctcg caaggcggta ttcaagccct aagccgttcc tatttcgcca 3697561 agcttgtgcc aaagcgccac gccaatgaat tctttggctt ctacaacatt tttggaaaat 3697621 tcgcctcaat tatggggccg ctgctcattg ccgttaccgc ccagctgacc ggtaaatcct 3697681 cgactgcggt gttcagcctg atcattttgt ttgtgattgg tattgtgatt cttgcctttg 3697741 ttcccgagga aaccagcaca gatgtcagcc agcagcaaaa tgacctgccc ctttaactgg 3697801 gagcaggtca ttcatcattt attcgcttta ttcaccttca gctgtttccc tttgacggtt 3697861 gtgttcttca tcactttgag aacatgaggg cctttaccat ttaaaatctc aacgtatgag 3697921 gcgttatcca tgatcgtgat gatgccgatg tcgtcagctg acacaccgtc aattttggca 3697981 atcgttccta caaaatcaac ggctctgatt ttctttttct ttccgccgtt aaaatacagc 3698041 ttcataatgt ctttattcag ctcttcgctt ttgtcctttt tgctttccgg acggtcattc 3698101 agtttagcta gaaattctgg tttcttcctt gccacttcct cttgagaagg tgcttctatt 3698161 ttttggattt caaatccgat atattcttca atgtcggcta aaaaccgttt ttcgaaggcc 3698221 gtgacaaacg aaatggcctt tcctttgttc cctgcgcgtc ccgttcggcc cgtgcggtgg 3698281 acatagcttt ctttttcaag cggcagatca tagttgatga caagggagat attttcaata 3698341 tcaatcccgc gcgcggcgac atccgtcgcc actaagtaac ggtactcgcc acgtttaaat 3698401 tcattcatga cgtcgaatcg gtcttcctga atcattccgc cgtgaatttt atcgcatgga 3698461 tatcccaagt catccaattc atcggtcagc tgattgacgt gctccttcgt tcggcagaaa 3698521 atgatgcagc tgtcgggatt ctccgtcatc agcacatctt tcagcaatga aaacttattc 3698581 tcttctctta cttgaatcac cgcatgttca atatttcttg tggttaggcc ggccgctttg 3698641 acctcgatat gctcggggtt ttgcatatat tgacggctca gcttctcgat atcctgcgga 3698701 agcgtcgctg aaaacagcat cgtcgtacgc tcagtcggca gatgcttgat aatcgcctcc 3698761 acctgctcaa tgaagcccat attcagcatc tcatccgctt catcaatgac caaataagag 3698821 agacgatcca acggcagcgt gcctttttcg atatgatcca gaacacgtcc cggcgtgccg 3698881 acaacaatgt ggcttttttg cttaagctca gctttttgtt tatcaaagga ggattttcca 3698941 aatacggctg tcgctttgat ccgtttaaat cgtccgatgt tcgtgatatc ttcctttact 3699001 tgcaccgcaa gctcacgggt cggtgttaaa ataagcgcct gcggcttgtt ttcatcccaa 3699061 ttcgccagct cacagagagg aatcccgaac gaagccgttt tcccgcttcc tgtctgtgat 3699121 ttgacgacaa gatcctttcg ttcaagggca gcggggatca cactctgctg caccttggtc 3699181 ggttctgtat atcccagtcc ttccaatgct cgtaaaatgt catgactgat ttgatagttt 3699241 ttaaaatgac tcatgtataa actcctgtct cttgcagatg ttctcattat actctaattg 3699301 accaaggcat atgtgttttg tcgaaaaatg atgtattaaa agccagcgat tccctggcgt 3699361 tttagctcct gaacagccaa tcgcgccagt gcgtcggccc ccgcgcgatt cgggtgcagc 3699421 gtatctccat ccatataaag cccgagtgtt ctttccggac cgatcgatgt aaagtatgcc 3699481 gagctgagga catttaagtc aatgagatat gttttttcct cttcggccaa agctaaaata 3699541 gaggccctgt accatctgtt tacagacgaa tggatgcctt cagaagtaaa atcggttgcc 3699601 cggccctgag gcgttgatag gatgacgtcc gctcctttcg cttttacctg acgaatcata 3699661 tcacgcatca cctctttaaa ctccgcttca gattctttat gcttcggatt tgtgtcatta 3699721 atgccaagct gcaacataaa ataatctccg ggtttaatat acttcagaat cgcctcaagc 3699781 tgtccatcat ttctgaaccc tctcgcgatc tgcccgccag acgccatgtt tctcacttga 3699841 aaggtgtgtt tatcgatata gtgaggcagc atctgccccc agcccgcctg cttgctgctg 3699901 ttgagcggat aataattgca caccgtcgag tcgccgccga cataaatggt tcgattcgtt 3699961 accggctgat cagacaattt ctttattttc aaggcgctga gcgtaaaagc ggtgcctgcc 3700021 tttccctctg tcaccagcag attcagctgc ccgtcggtga cgggaatttg gaacgtatcc 3700081 tccgcgccat cccctgtcat attgatgacc tgaaacacgc cctccgctgc cacactggcc 3700141 cttgccgtat tgccaagcgt caccttcacc tcataaaggc cattcgggag atcaacatta 3700201 aacgtgttat tgcttttcgt cccatacgct aaaaactgaa ccgcatcact cttcacacca 3700261 gccccggatg ccgccacatc cctcatattc tccggtgttt gaaaaccgta gccctttgac 3700321 cggtcatacc gatcagacgc cctgacacca atataaccag gctccatcga accgcttcca 3700381 aagtcaaact gatacacctt cggctccgcc gccttcacat tctcaatccc gccaaaacac 3700441 agcatcagca tcatcacaaa aaccgctgcc atccattttt tcatcaagac tccccctcta 3700501 tgaaaacgaa tacattaatg catactcggt gattgtttct ttatgatgac tgaattaaga 3700561 aaaaaattgc gttgaggaat aaaaatgagg ggagagtctc aagaagggga aaatcagtgt 3700621 gacttcttgt cacacttgat cacatcccaa cctccgcaat agaagcttat ttggttttct 3700681 tcgtcataca cataataacg gagtctttcc cattgatcgt cagtcggtac aatctccaat 3700741 gcaaccgaat cgatggattc aaggtcatcc agctttgatg cactaatgtt ttcaaaccgc 3700801 aattgaatgt cacaggtttg agcagatcgt tttcattcaa acacaggaat atgaatataa 3700861 cgatcatctt ctttcatata gaaagaaaac tcgtttaatg taaatggacc tgtatcctca 3700921 tcagaaagat gctgtttcaa tttctcgtat tgtgtgatat tcaaatgaat tccctctatt 3700981 tatatgattc accgccaatc atataaatgt ccacagcatc gtattcaaac catatgatcc 3701041 gttcgcctga gtccgttagg cattggagct tcccttctga aaaatagctt ttatccggtt 3701101 gaggatcagt gatcagaaaa acatcatcat tgatggaagc tagcagaaag agaaaatctg 3701161 caatatcccg gtctgcttcc tgtaatatgg attggaaatg gaattccctt ttggccagct 3701221 tcgtcacctt gtaagcatga ccttcaaaat actcggacag gtcttctata aatgaaccag 3701281 tcgttattac ctgtatcatg attcgatcgt aggcaagccc tgcccaaaaa cgataaaacg 3701341 actctgcatc ttcaagttcg catgccataa cggtttggtc aggcttaagc tcgatcatgt 3701401 ccaaattgcc aatactgctt atagaggtta tttccataaa atcttcccct tatcagttgg 3701461 atagcgcaac gcaaatctct tgtctgactt gttcatacaa gagaatgtga tgatacagat 3701521 ccttatcgtt tttgatcata tccggaagta tgtcaggata cagctcaaaa aagcttttct 3701581 ccaacgaacg ccgctgatgc cggggtatcc ttttattcgc cagcacataa tccaaactgc 3701641 cagcaacaag cataaaaaac tcatagattt ccgcttcaaa gccgtacaat tcatcagggt 3701701 actgcttttc ttcaagctct cgctgtcttt ttctcagttt ttgaagcacg ttgatcctct 3701761 cccttccgca ataatctcat ttatttcgaa acagaatagg cggatcatta tctatcgcct 3701821 ccaacagctc ttcaccaaac acagtgattg cacatttcca cgggtctccc aaaagtcccc 3701881 aggagaagtc ctgatgaaaa aagaaataat agtctccatt tggaaatacg ggaacaggcc 3701941 attcgccaaa ttcatcctta ggcattgcct gatgaggact aaaggtatat ccgtcatgct 3702001 gccaatctag tgcgtacatt acatcgttct ttccagtacc taattgaaat gcttttaaaa 3702061 tagaagtctc taaatcactt agcactccgc tcacatcatt atgaccagct ttactgctca 3702121 tcgcgcttga gatatcaaac actcgatatg gatcaggcgg gatgatgtga tgacatctgc 3702181 ttccgggctt ccattttatg atcttgttca cttctgacca gatgcggtct tgttttgtct 3702241 gacttaaagc gcgccaattc atcataatct catccctaca ccttattgga tatcctgctt 3702301 ataaacacca gaagaggcca ctgcgtaaac agcgtaactt gtcagtttca gctgttgaac 3702361 atctaggcct tcaccgttcg aatcacagca tgttatctct tccatctctt gactcacatc 3702421 ggcagaaatc aaataaagag acgacttaag gtctgcactg taacaattga acgtcccaac 3702481 caaaaaacct tcttcggata tcgcgagctg atcaaatgct tctgagtccg gctctttatc 3702541 cgacagaatc cacacccgtc tcacgaccgt ttcatcaaat gcggcaatga ctgcatctcc 3702601 gtaatacagc atataaatca agccgttttt ttctgcaagt ccataacaat catctacagc 3702661 aggcgcatcc atttcttcaa gctttctatc aatgtgtatt tccttctgct gaccatctaa 3702721 cgtaaaacac cacacactat ggccgttggg attctcatca tgataaatcc cttcatcaca 3702781 taaaccgacc caaagctgtt gtttctaatc caaaagacag caggaaaccc ctgaaggcaa 3702841 gtgaaaaaca cttttcaccc ttccctcttc tgaaaaaacc tttaccttcg gctcgtacga 3702901 ttcgtaataa acgaagacat agccatctgc acattgttga aagagcagaa tatcactgta 3702961 tgaaatctgc tctttcactc taaaatcccg aacatcaccg gaaggatcat agattgtaat 3703021 ggtgatacca cctttcaacc cttttccaat gtagacacgc ccctgtggat cagcatggaa 3703081 aaaacaatct tgggtgttct cgttgatgat tttattcaat tttaattttt tcattggtta 3703141 tgctcctagg ttcgaaatga aatgataaga ataaaccatt tattagctat tagtaacgga 3703201 caacctagtt tcattaatcg ttttgggata aatctacttt ccaattcagc cttaaatcat 3703261 ttagtgttta attggtatgc ataaaacgat tgatcatcaa agcgaactgt ttcagcttct 3703321 atagcaatca gcattctgtt catgtcaata agaaagttag catttgattg atactccgga 3703381 attatagaat ttgatagatt cccgattcct tctggatgat aactcatctc aaatacttgc 3703441 caattgtatt cttccggatc tattttttcc aatctcatgt cgccaacatc tgcactataa 3703501 taagcggatg ccacattttg aaatgaaatt ttatgcgtat attcaccttc atcttcaaaa 3703561 accttaatat caagtgagag ttctttttta aacacattaa aatctaaatg aaggacactg 3703621 caccccttat ctatataatc aacccattca ttaatcgttt gatacattgt catcccctgc 3703681 ctctttttaa acaataacgc cttgccacca agcagaaaac aaattactcc gtatattgtt 3703741 tgatccaatc atttaaatca tctgttgaat gcaaataagt ttctgatgaa tctttcaaat 3703801 caatcccact tagaaggatt aacatatccc agactctatc gtcttctact tcggggtcat 3703861 ccgcataaac ataagttcca gcccaatccg acacttcttc tcttgttgtt tgtccattta 3703921 agacactttt gattttattt atgcattcta ttagatttgt ctcgctcaat ttgatcacca 3703981 cgtattcaag tactaaatga ttttttatta gtatgcaaag caccgtactg atatttagat 3704041 attgaagctt tttccgtaaa agatatgttc caaaaggttt ccaatctacc aataaacaag 3704101 ctcacatccg tattccgtgt gcaatataca taaaccaaac tggcacttag gctcaaccaa 3704161 aataaaacta tgattgagaa tcccttcatc gaactcaata cactccaata agcagtcaag 3704221 gtgctcgaga cattttccaa aagaacaaac taacgcacca atttcgctgc tgtattgatg 3704281 aaacagcaga acgtcccggt catcgtaagc aacatatgac tgagatattt tccagatcag 3704341 ctgtttcgct tccgtttttt cgagggcatc aacctcacgg gtgttggctg gtattgaatt 3704401 tgataaaacc agctcaagca attgcctgct ttgcgccaga tcagcaaaac gataagtgaa 3704461 gcctctttct gcacaaggga ctagtttttc tttgatttcg ctcatcaata aacgtctttt 3704521 attctcggcg agtttttcga tcaatctttt ttgcatgagc cgcattccct ccgctgtcaa 3704581 tttctcaact tcttttaaat tgattcatca ttctcttgtt ttcgttgtcg ttcatgttta 3704641 gatttgttct aaaaaagctt gtatcgctta tcgatacaag ctttatcttc aactgcttaa 3704701 aactcaccca gtgggctttt cacaaaacgc tgggaacctt tttggcaaat cctcttcatc 3704761 ccaatcaatt ctatattttt agattctttt gtcatacaaa taagagagga tggtaacatc 3704821 tcttatttaa tgttccatca ataaatgccc catttttatc caatgcagaa attatttata 3704881 attaaggaag tttagaagga ttttttgtat tttcaagatt taattttaaa gcggtcacaa 3704941 aagactctag cttttcttca ttacaattaa tttcgaacaa gttggagttc gacttacttt 3705001 ctttataatc atcaaatata attttaatct taattctgta atttccgttt tcttgatcaa 3705061 tactaagaaa taagaatggt tcaatagtct ctaaactgat actgtcttga tttcctttta 3705121 tcatagtttc gatcccagat atcaacacct tatattcact ttctaataaa acagcagaaa 3705181 aatcgcgaac gacggctttc ttattttcca acaattcaaa tacagataaa ataaatggat 3705241 catcgtccaa ctcttgatac cttctcggtg ttaattcaag ttctatacaa tcatctttta 3705301 ttttggccat atttcctcct catttaaagt ttaagtgagg gtagttgtca tccccccctc 3705361 gcttaacctt attaacgcct tctcttagat ttatttcctt ttccgtgtgt atggaatacg 3705421 tgtttagaac ccttagctct tgaacttcca taagctgtga ttactttacc ccttttattt 3705481 aaaacaactg tagctttttt tccaacatat ttcgttgccc cattaggttg ttttattact 3705541 tttttagggc ttcgcacagc attcagtttg gcccttaaat tgactccacg gcctccattt 3705601 cttcctatag attgattaag tccatgtctt gtatgacctg tgattttaac tgccttcttc 3705661 gtaaacttat aggcgcgact agcaccctta aatatcttcc caggaccaaa attagaagca 3705721 gctgcccaag cagcaccttt ccatccttta cctgatttat atgccttata tccatcatag 3705781 gctgcaaatc cggcatttac cacaagccat acccaatgcc cgtccggatc aacattcatc 3705841 actgggttat tatttccata agcataccca ttctgatcca atgaatctcc gtcgctgccc 3705901 gggtctgggt cgagcgatag gaacacgccg tttcttggct cgtagtagcg ggccatgaga 3705961 tagtacaggc cggtttcttc gtcgtattgg tagcctgcgt agcggtagcg attgtctttt 3706021 acttcgtcgc ttgcttcggt ttttgttgga tttccccatg cgtcgtattg atacttggca 3706081 acggtttttc cagtgctgtc tgagatcgcg atgatgtcgc cgtgagcgtt gtagtgatag 3706141 aaatatttct taccattttc tgtgtaggat aacagctggc cgctgtctcc gtacgtgtat 3706201 gattttgtga cgttgttgtc cgcgtctgtt tcatacaaga cgttcaagct gtctccgtcg 3706261 tagaagtagt tcgtgacttt tccgttgacg gttttttgga ttctgtttcc tttttcgtca 3706321 tacttatatg ttgcgaatgg cttgtcttcg ccttttttgg taacggcggt caggttatct 3706381 tctgcatccc acgtatatgt gaatttgccg tcggatgtgc ggttgccgtt tttatcgtaa 3706441 gagatgcttt catcattgac ttttgtcagc tggttcatga tgttgaagga agcgttcacc 3706501 gttttgcttg agccgtcttt tatagttgta acggttttcc ggtttccgaa tccatcatat 3706561 gtgtattcaa taacagtacc gtcttcatgg gtttctttga caagctgatt cagcttccca 3706621 tactcatatt gcaccttgcc gcttgctgag ctgtttatcg ttgtgcggtt gccgttggca 3706681 tcatattcat agctttccgt cagaatgtct ccgccgtttt tgtcaccgat atgcagcgag 3706741 cttacaaggt ttctttcgtc atatgaaaaa cttgttccgc cgccgttgcc cgtaataaag 3706801 gtttggacgt ttccattttc atcataatca aatgaatatg aggatgtact gtctttcatc 3706861 tcaatcattt gatccagctt gttatacgta aattgattcg ttcctttttg gtccccatga 3706921 atccacgaga aggttttcag cttatcggag tcactaggat atgtccaagt ttggctgccg 3706981 ccgcggtctg tcagttcggt taaacggttt ttgttgtcaa atgtccgttt ctttgtggtg 3707041 ttctgctctt tattgacgac cgacgtttca tttccatttt tgtcatacgt gaaaatgtac 3707101 ttttctgtac cgttatacga ctttgatttc acccggtctg ttccatcata agaaagagac 3707161 acttcgttgc catttggtga aatggttttg gtcaggttgc tgttggcatc atattcgctt 3707221 gctaacacat tgccgagagg gtcagttgtt ttgacaagct tgcccatgac atcatattcg 3707281 aatttatagg tttgatctgc tcctgcccgg atggttttgc ttacctcatt gccttcctta 3707341 tcatagctgt gaaggataga cgtgccgtta gagagcgtca tgtttgtcaa ttggtctgcc 3707401 tgatcatacg tataggttgt tttttcacct tttgcatctg tttcagacgt tttcttacca 3707461 gtttcatcgt aatcagttga agtggcgtaa cctagttcgt cctcttcctt ggtcacatag 3707521 ttgccattac tgtcatacgt gcttttagtc agaaggcttc cttcaatcaa acggatatca 3707581 tcaaaccaga ctgtgcctgt cgcactcttt tggaacagaa tactgatatc gactttattg 3707641 atcggctttg ttttagggat gacgacagct gctcggttcc attcctgtgt tccagaaggg 3707701 aatttcgcat tgtagatgcc tgtgctgccg tcagcgtaag tgacattcgc ctgcagagaa 3707761 tagtcttttt catctgtaaa tttgacgctg cttgctttcg acattcctgt cagtgtgaga 3707821 taaaccggtt tgtcatttgc gctttgccct aagacaacgg tttgttttgt tactgatccg 3707881 gcttgggacg cactggtccg ggcagctttt aatgatacat catcattaaa gccttcttca 3707941 gaatcaacgg atgctccgct tacattccag ttttccgttg ctgatgtgaa gctgctgttt 3708001 tgaactgggt tatagcttga tgatacttcg cctttttcca gctggacttc atcaaaccat 3708061 gcttttcctt tgccatcttt atctttatga tcgacttcca tatacacaac agctttgcct 3708121 gcattcgctg gagtcgtaaa agtgatttgc cgttttgtcc agtcattttt tccggctaat 3708181 gcactgtatt cattgtgaat ccattgaatt cgtttttgat ctttgtctcg caaatcaatg 3708241 ttaaaatagg ctcttgattt cgcaagatct gttttgattt tcccgcttaa tgtataggtt 3708301 gtattcggct ccagctcaac tgtttgtgtt gctgacgaat acccatgatc tgttccggca 3708361 gacgttgatt ggctcaagac ctccaatgcc tttgatccgg aaagaactcc gcttttatcg 3708421 gcgatgactg aaattttgcc gctgtcttta gaggcagtca gattccagcc ggatttttga 3708481 gcttcaaagc ttccatcttt caaaatatta gttgaagctg ataaatcttt gctcgattga 3708541 atctggtttc catatttatc ataaacagct gctgacgatg attttccgct ctgatcggtt 3708601 tcggatacag catccagtcc gtcataagca atatccgtga cattgccctc ggtatccttc 3708661 atctttgtga catcgttgtt tttgttgtat tcgtatgtct cagttccata tgcatcttta 3708721 accgacgtaa cgttgccatc tttgtcatat tgatagcttt ccgttgcttt tccggtgccg 3708781 acgtcatttg gatctacatc ttctacaaca ttgttgcctt catactttgt attcgttgta 3708841 atttttaacc cttccgcatc atcaatgacc tgaatcggat ttcccgcttc attatagcca 3708901 tactgtactt tccggccatt tggctgtgtc atgagaagcg tctttttatc agcatcatag 3708961 ctgtagacat atgtttcttt tttagcgttg atcgcttttt cgagacggtg accgctatac 3709021 tgatattcgg taaagacagg ctttgcttcg gtactgttag ctgaatattg tttgacaagg 3709081 cgcccttcac tatcgtagtc atagcttgtg acagtcccgt ctgtatctgt aaccttcttc 3709141 agcaaatcat tctcatatga gtaggtgact ttcttattct taggtcctgt gatggacgtc 3709201 acatggccgt tttcatcata ggtaaatgta agcttgcggc ctgatgcatc tgtaatggcg 3709261 gtcagttgat ttttgtcatt gtaagtatag acagttgcat tgttatggcc atccactacc 3709321 ttttggagtt tgccgccttt tttattgaaa taagcgttgg tttgatcctt tgtttttaat 3709381 atgaactgat cagctgtttc tgttaattca agatatacac cggtcggcgg ctgatacgtg 3709441 ccatcggctt ttttcgtgaa tcgatgtgtc gtagcgtctt catcgatata cattgccccg 3709501 ccatccgttg agatgacaga tgtttctgca tcagcatacc agccttgtcc aaataagtga 3709561 tcagagctgt caagactgtt gtaggttctc gataagccaa gtcccggacc gcgtccatca 3709621 attgacaaat cttcttcatt cacaatgaca ttgcctgtcg caccatttaa ctggccgctt 3709681 gggatatcaa tgatagacca gtactcttct gtacctagga attctgcgcc ttcatggaac 3709741 gttgggttaa agggcgccgt tggaatcgtt tcaccattcg catcataggc gacaagcgtg 3709801 aaagaataat tcttcttccc tttgtaattc ccatttgcat tgttatagac aggtgatgga 3709861 tcgagggcta attccccgcc ttttccatct gtatgaagct tatagcttcc ggctttgatt 3709921 tcctcagaag tcggccagat gtttttattt tgggttgtcc aatgatcagc atcaccaaca 3709981 tcaaaggact gatattcttt accgttgtaa atgttaactt tatagccctt cgcattttga 3710041 accttttccc atatcaaatt cacataaccc gtttgactcg attttgtatt tgtatacaaa 3710101 tagccagtta cattctttgg cctagcgata tcaggaagtg ccggggtagc agccggggat 3710161 gcaatggctt cgccgtcttt gttgtatgcg ataattttaa acgagtaatt tcttttggct 3710221 ccatctcccc cggcgttttt ataggttggt ccgggattga tcggcagctc tgctccgctt 3710281 ccgtccttta ggtgaagagc atattttccc gccttgattt ctgcacttgt cggccagatc 3710341 tttttccctt ttgtggtcca agacgtctga tttccgagat caagtgtctc aaagcctttc 3710401 ccattgaaca cctgaacctt atagccggtt gcaccggata cagctttcca agaaaggtcg 3710461 aagtatcctg tggcattccc attattgtag ccctttgctg acggtgcttg tgcttttcct 3710521 acattaggga taacgggctt tgccggtgcg gacatcgctc cttcaccttg gtcaaatatc 3710581 gcactgacgc caatccaata gtttttgctt gtagcatagc ttccgccgga attcttatag 3710641 accggggatg gatctaatgc caattcagct ccatccttgc cgtccagatg cagtttatat 3710701 ctcttggagg caatttctgc gctcgtaggc cagatttttt taccttttgt gctccacgac 3710761 gtgacgttgc ctgcagaaat cgcttgatat tccttaccat tgtaaatcca taccttatat 3710821 ccttttgcgc cttcaacctt tttccagctg atatcgaaat aaccagtgga atcgccgttg 3710881 tgataggctt tgattgtagg tgtgtttccc tttggaatgg tatacgtcac ttcaatatat 3710941 ggtttattgg cggagttcgc tgaagaaatt agttttttcc aatattcctt gccgtttccg 3711001 tttgtatgaa gcttaaatcc atagttggcc ccgccggagt tccatgactt tacagcagcg 3711061 gtcacatcat aactcgccca ctgtccttta tggacgtcgg cttttccgat atttttagat 3711121 gccggtttgg tgttccatgt cacttttgca ttatcataat tgctgttgac cgtatccagc 3711181 caaaggccgg ttgcctttgt tccataatag gaatgggcta cgtatgtttt taatgtagct 3711241 ttagtgacag tcatattttg aattggcttt aggttgttaa atttcatgaa cgcatagttt 3711301 gtgcctgttg ttttgtcata atagcccgtt ttcagtacat aggcctttaa attagcatcc 3711361 catttttgtg aggaggccga atagttcgtc gtcgggtagg cactcatgac aaacgtatcc 3711421 gatgaaacag ataaagaagt tgacgggtcg atagatactg gatatacgcg ttctgggtct 3711481 ttcagccagt tctcgtctgc cgtaagatga agcaaatacc cttcttcatt cttttccagc 3711541 ttatagctga ctttgtctga ccgttcaacc tcgccggaaa gctcatctag ttttgaatcc 3711601 gtcataaaag gcttaggcac agaaaaaaca acttttcctt tttcatcaga aaaatcaatg 3711661 gatccatcct cttgttcttt agcctgcaaa tcggttttta actgaaatgt aaatgtgttg 3711721 tatccattat actgatgaag gactaaatct tcttttatgt tttcattgaa tgtgaaagtc 3711781 tgaagatcaa tattcggaaa cacatccgga tacacaatct cattactgtc agtcttataa 3711841 tctgctgagg tatctttcgg agtaagtgaa gttttattcg ggcctttcgc ttctgctagt 3711901 gaatatgtaa ccttatggtc attatgctca aaagtcgcat aaagcccgtt cttcatttgc 3711961 ttttgaaaat ctgaattcaa aatagcgttc tctgtctcga cttgtttgct tgtcgactct 3712021 tttaactcag gagaaatgtc ttcccagtcg gcatccggtg tttcctttgt atgaatagga 3712081 tcaaggtata cttcctgttt atagacaccg tcaccttcat aatagagttt tgtattttct 3712141 gttctttcag aggtgatctc accctctttg tttatatctt ttggatcaaa aggtacagct 3712201 tcctcagttt gttctttctg aagagtttct tctggatcat cggcagcaat acggtttcca 3712261 ttctcttctt ctgtagattt tgctagtaca tcggctggca ctaatgaaat cattaaagcc 3712321 aacactaaaa atgctgcaat gaacctttta aagtttcgcc tctttctttt tttcatttcc 3712381 tctctccttt tgtaataaaa gtaatattta ctcaataatc ttaactagac tgaaatatca 3712441 ttacaatatt tttctagaaa atttatctta ttttaaggat tagcgagagt caattgacct 3712501 aaaacaaaaa aaggccgcat aggccttttt acatttttta ttgtatttgt tcaatatccg 3712561 taccctcagc tgtcacattc gccttcccct gcctcctgac aagcgtcaag gccatgcccg 3712621 caaagatcat tacgatgcca agcgtttgat agaggtcagg gcggaagcct gtgaagacgg 3712681 tatcgagcac gatcgcgaca gcggggtcga gaaatacaat gattgaaata aatttcgttg 3712741 ataaaaatcg taaactgtca aaaaacagca aatatacaat acccgtatgg atgatgccgg 3712801 tagataccac cataatccag tttccctgag ataggtccgc aaaagcgcca aagtgaataa 3712861 acggaatcag gatgataacc cctaaacctg tctgcaagaa ggtggtcgtg taaggactga 3712921 gattgtgaat gccttttccc aataaagtgg tgaacgcata aaacagtgcg gcgagaactg 3712981 cccatatgat ccctgatccc atcagctgtg tcaatgatgt gctgccgtta atcccggaaa 3713041 tcagcgcagt cccaagaaag cagatgataa tggagctgac ggagatcaca tttaatttct 3713101 ctctgtagaa gaagctcccc agaagaagaa caagcaccgg cgctagatga taaacagaga 3713161 tggcaattgt aacggacgtt tcttcaaaag acttaaataa gaacacccag ttgaatacaa 3713221 gaaagaaacc gcacgccaat gtttgcagca cgtctctctt gctccatttt tcagttttat 3713281 actggccgga cgccagccag caaaagccta aaaacagcgt cgcgcaaagg cagcggacaa 3713341 agaccaattc aaatgacggc agattggtat gctctgagaa aaagccgatg gagccgaaaa 3713401 tcaccataga gatgaccatt ttgattacgg ctgttgattt ttgttttgac gatatggaag 3713461 gatcctgttg catcaaacgt attctacctc caatactgca tagcataaac tgttttttgt 3713521 gaattcagaa atctacacat agaattcctc ttttttacat gtagatatta taacacttct 3713581 attctaaata aaaaaaagcg cccaagggcg ctttttttac aaatctatcg aacaatcaaa 3713641 accgggcatg ttgataattg agacacttta tggctgacgc ttccaagcat catttctttc 3713701 aggccgctga tcccccggct gccaactaca atcaggctga cgcctttctc ttttgcgtga 3713761 tttagtatct catgcgccgg ctcgccattc gcgtaaatgg tttcagcttg aacgcctttt 3713821 tcggctgctt tttcttttgc attctcaagg attttcaggc cctctttttt aacctcgttc 3713881 ctgatttcat caataaagtg ttcaggcaca tagacaattc ccgtcagaga agaagtcgtg 3713941 acgacggctt ctctccccac atgaagaatg cttagttccg cttgttgctc ttttgccaaa 3714001 tgcactgcgg catcaagcgc ttttgcactc atgtctgatc cgtcaatcgc tactaacatt 3714061 ttgttaaaca tgctcttccc gcctttcgga ctgtgggtgg ttcatctttc tcttttattg 3714121 tccgcctgca tttcgttatt gtcaattgaa gcgcatgagt tttcaaaaaa ttgtcagaga 3714181 ctctctccgt ttgtggcgat aacctgctga taccagttga agcttttttt cttgatgcgg 3714241 ttaaatgttc catttccttc attgtcccgg tctacataaa tgaagccgta gcgctttttc 3714301 atttccgcag tagatgcgct gacaaggtca attggccccc atgatgtgta tccgattaat 3714361 tcaacgccgt ccgcaatggc ttcgcgcgct tcaattaaat gatcacgcag atagttgatt 3714421 ctgtaatcgt cctgaatcgt gccgtcctct tcaaccttgt ctacagcgcc aaggccgttt 3714481 tcaacgatga acagcggctt ctggtaacgg tcgtataagg tgttgagcgt gatgcgcaag 3714541 cctttcggat caatctgcca gccccattct gatgatttga ggtaagggtt tttgactccg 3714601 cccagcaggt tgccccctga ttttgcaagc tcttccggat ctgtgctcgc cgccatcgac 3714661 atgtagtagc taaatccaat ataatccacc gtatgttctt tcaagagctc ttcatcgcct 3714721 tcagccattt caatttcaat attgttttct gccagatagc gtttcatata tcccgggtat 3714781 gcgcctcttg cctgaacatc tgagaagaaa agtgttttgc gctcattctc cattgccgcg 3714841 aagacatcct ccggcttaga agtcatcgga taggttgtcg ttgccgctat catacagccg 3714901 attttcgaat caggaatgat gtcgtgaccc gctttgacag caagagcact ggccacaaat 3714961 tggtggtgtg ccgcctggta catcgcgttt aatttgtttt ctccttcttc aaaaacaaga 3715021 ccgcctccgg taaatggcgc atggagcact acgttaattt cattaaacgt catccaatac 3715081 ttcactttgt gttgatagcg tttgaaaacc gttttggcat agcgttcata aaactctatg 3715141 actttgcgat tcttccagcc gccataattt ttcactaaac cgagcggcat ctcataatga 3715201 gagatggtta cgacaggctc aatatgatgc tttaacagct catcaaacag atcatcataa 3715261 aatctgaggc cttcttcatt gggctcctct tcatcgccat tcggaaaaat tctcgtccac 3715321 gcaatcgatg tgcggaacgc cttaaatccc atttctgcaa ataaggcgat atcctcttta 3715381 taacgatgat aaaagtcaat cccgttgtga tacagattca aggaagtcat tgattcatca 3715441 aatggagaca tgatcccgtt cggcgatacg tcagctgtcg aaagcccctt accaccctcg 3715501 ttataagcac cctccacttg gttggcagca actgcgccgc cccataaaaa tccttctgga 3715561 aatcgttttt catttgaact catattgatc accccattag ttttttcaag ataaagcaag 3715621 cagcgcttct tttggctgca ctttaccgat ctctttcacc ggcgaaaacg aatattggtc 3715681 tgtgttggtc acaatcaccg gggtaatgac gtcatatccc gcggctttga tttgctccag 3715741 atcaaaggac acgagcggat ctcccggtgc gaccttgtcg ccttctttga tgtgagccgt 3715801 gaaccattgt ccctccagct ttaccgtgtc caatccaatg tgtatgagta tttcagctcc 3715861 ctgatcactc gtaatgccaa ttgcgtgttt tgttttaaaa atggtggtaa cgcttccacg 3715921 aacaggcgaa acaacttctc cttcttcagg ctcaatggca aatccttttc ccatgacccc 3715981 agcagaaaac actccgtctt tgacttcact taaggctttc acttctccct taatcgggct 3716041 gtgaatgatc tctctgctgc cttcatgcac tgccggctgc tggctgccgt cagaaggcac 3716101 atcctcgaat ccaagcaaat acgcagctgc tgttcccgcc gcaaacgcaa tcacaaggcc 3716161 gatcatcgcg taaataaacg ttgggccgat aaagacaggg atgctcggca gacctgcatt 3716221 ccccccgacg atataggaag caacacccgt catgccgtaa aacgcgccac cggctgcacc 3716281 gccaatcaaa gcggccgcaa acggcttttt caatcgcata ttcacgccgt acatcgcagg 3716341 ttctgtgatc cccatcagcg ccgtgatgct tgtggtaagc gcgagtgatt taaatttttt 3716401 gtttctagag cgaaggaaga cggcaaatga tgctcccgcc tgccccatat tcgccaaaaa 3716461 catagccggc agtaaataat cgtggccgtt ttgagcgatg ttgttgatca tgatcggcac 3716521 aaaggcatag tgcatgcccg tcataatgat taaagagaat gtacccgcca gcaaaatcat 3716581 tgccacaagc cctgcatgat caaacaaata attgacccca gaagacaagt attctcctaa 3716641 aatagcgcca agcggaccga ctgtaatcaa tgtcagcggc acgacaatca atagcgtgaa 3716701 tgtcggaacc acaatcaatt tgagagatgc gtgtgtaaaa cggtcaatcc atttttccac 3716761 gtatgaagca atccaaatcg acagcaaaat cgggatgacc gttgacgaat aagtggcagc 3716821 ggttacagga agcccgataa aggaaatcgg tttccccgca ccgagcaggg ctgtcaaatc 3716881 cggatgcagg atcgccgccg caatggcagc cgctacgtac ggattgcttc cgaattttct 3716941 cgccgcactc atcgctagca ggagcggcag gaagtagaac gcaccgtcac cgacagccgt 3717001 caaaatgaca tgaacctggc tcttctccgc catccagcca aacgtgactg ccagcgccac 3717061 aagtcctttg atcatccccg ctcccgcaat cgcaggcaga ataggggtaa acaccccaga 3717121 aatcacatca aagaccgcac tcagcacatt ctttttctga gaggatgaac cagcgctctt 3717181 ttcatcactg agattgctgt gccgcacaat cgcctgatac accttcggca catcgtttcc 3717241 gataatgatt tgaaactgct cgccgctgat attggtgccc atcactccag gcagctgctc 3717301 cagctgactg cgatccgcct tcgcgttgtc atgaagatta aaacgcagcc tcgtcatgca 3717361 gtggatcacg cgctgaacgt tttcttcacc gcctacgagt tgtaatatgt ccttcgataa 3717421 tttatcataa tccatgtgta tacctccttt ttatgggggg actgctggat gaaaggtggc 3717481 cgcctttcac cagctttttt tgtatcaaat gctgcatcac ctcctaaaag agaataaaaa 3717541 aacctaaatg acacagattg cgagagtctc ctcctgcacc tgcaccattt aggttttgcc 3717601 tgctttcgca gtaacaatcc tgacgggtcg ttttatttgt ttgtaggtat actttagcac 3717661 tagattcgtg agatgtcaac gctttcattt ttggtgttga ctatcgtttc tagaacaaaa 3717721 gtaatcataa agatttgaac ttagtattaa cttcaataaa aaattattgt aattaaaaac 3717781 cttgaaaggc attttttcca atcaaggtta tgaatcgtta ccgtttaaat ttttttaaag 3717841 acttctttat ctgtactatt acattcttta gccaatctat tggttctaaa ttaaacgcag 3717901 gaagatacac gccatctgcg caagattgaa tgtaatcgtt tttcttattg tctgaatgct 3717961 cactttcaat aaaatccgtt aaaaagacaa tagcatcctc caaatattcc ttactttcct 3718021 ctattaataa ctcttgtata gcgtcatcag gagtttcaat atcttgatgg aatgttccag 3718081 ctaaaaactg aaaaacaggg tccttctgtt tattgatcaa taacatgtca tcttgctcct 3718141 ttaagggaga ggtaacggga taatgttaaa atcattcatc atctaataaa tcaagataat 3718201 actgatcatt ctcttctatt tttcttaaga actcggtaag agaagttgca atttgaatat 3718261 cataatagta aatcggattt ttattattat catttaattc aattgacatt aatgccgatt 3718321 cactaccttc aaaaaatatt aatttatcat tctcaaactc atcatatatt tctatgtcag 3718381 gataaaattc aaagtcattt atcctcaatc gaaagtctct tacagaatat ggatccaaaa 3718441 tgcgattagt attaaactct gatcctttaa taaacccata gccaacttct aaataaaaat 3718501 tcactaattc actaggtaat tttaagttta aatttttttc aacctcttca atctcacttt 3718561 gattcactgg ataaaaatca ttttctttgt ttgattttat aaaattataa ctcatttttt 3718621 tttgcctcct ttaaataatt catttgctgg tgagcctgta ccatgaatcc cagcttgatg 3718681 ctcgttagga aattttgctg gatgcatatt ccaccattca tgttctccgc caaaagtatt 3718741 ttcaattata tggtgagcat catacttatc cccttttttt ctaataattt tacctgtttt 3718801 ttcagataca acattttcct tataaacagg ccatttttgt ccagtgtttt cttcccattc 3718861 ttttataact ttatttttta ctttatcaaa tttagtcctg tgttttgcag tctctattgg 3718921 tgacattttt ttatattctt tatttcttaa tgcttccttt aatttatcta tttgattttt 3718981 aggtaattct ctacctgtgc gttgttctat atctctagca tactttttta ttaaatcaga 3719041 attaatttta ttagcagatc cacttacatc attcgcaatt ttccctttat ccttagcaac 3719101 gtttttaact tccgaagcct tcttagcctt tttcccatta ttaataagtt tattaatatc 3719161 tattaacttt tctaacttag ctattttggc aaatggtact gagtttatgg aggcaacaac 3719221 acggtctttc cctgtgactt tttcgcctga taccggatct ctgcccgtgg ctgctttaaa 3719281 tagatcatac acgccggtaa gttctacagc cgtctctaaa attttcacat atccattctc 3719341 atccacttta atgtccgaaa gcgagacgac aggttcaagc ttcatgtcat taccagatat 3719401 gtatacattg taaagtgtat cattataaac gacttgctta acctctgcat ttgagaaatc 3719461 agtttttata tgttctctat gttcactcgt attatacact ttaccattga taacgatgat 3719521 atttttactt acctttttag aatcacccgt tttgacaact gaatccactt tagacttttc 3719581 attctcggct aatttcttca gcatcatctc catcggtgaa tcatccgcct gcttcatttg 3719641 cgggttaatc gcgccgaaga tttggttgat gttttcttct tcctgtgatt tcaggatgga 3719701 gccgcttttg tagcctgtga tttcaatttt cgggccggtg tacatggttt cgagctgatc 3719761 aatgtatttt ttcatcgttt gaaaatctga ttttgcggct tctagtgctt gggtttgctg 3719821 gccgtcaaat tgaaagagct tattcagggt gtctgaaatc agccgctcag cctgttctgt 3719881 ttccatccga aaaaaggaat cattgactgt cggcaggctg acgatgtgat ctatggctga 3719941 tgtctggcga ttgactgcgt cagtgagctg ctctgtcact tctcgtgcat gcttgacccc 3720001 atgtctcgca tcgtgtgaga gaaaagcctc tgcgatcatg ccgtgggagt tagattctac 3720061 agaggaaatc gcatgctgtg tttgtttcag cacttttttg tattcgtcga taaatatgcc 3720121 aaagaaaagg agaaaaggct tgtggcactc ctcgtaaaag gtccggatgg catctccgcc 3720181 ttttcctttc agcgcatcct tcatgcctgc cagatgctca acgctttttt ccagcttctc 3720241 cagctgttgt ttttgcttgt ccagtttctc aatcgtatgc tgaatgccct cgtgaagagc 3720301 gtggacatct aatgttttca atcccttgtc ctcccgcgct ttatttcatg gaagatgata 3720361 tgttttcgtc cgtttccttc atggcgttta ccgcgctttc cgtttgtgcg atatgcttgg 3720421 ccagaacaga cgcatatgct tcagtgagct ctttgatgtc cttatttaat tgctcgatgg 3720481 acttcacaac attcaaatgg tttctgcctg agagatgacc gggcaatgag gacttgagtt 3720541 cagctgaatt cttgagctga gaaagccctt gcttcactgt gtcatacacc attttaattt 3720601 cctgtgccat ttgtgctcac ctcacttttt atgtttttcc ttctctattt catgctctat 3720661 cctcgtgatt tggcgtctta tagaatacac atcgccctct aatgagtgga tttttccttc 3720721 tatgctttcg atgattccgc tgacttgatc gcttttgatt tgctgatatg ctttgttcat 3720781 tccttcacga atatcttcaa accgctcagc atgtgttcct ctccatgcct cccggttaag 3720841 atgaggccgg tgaatgagat gctgggcctc agagaaatcg tgtttgattt gcctaatttc 3720901 gtgcagcact cgttttaatt gatggatctg ttcctgcttt tcatgtaagt cggcttttac 3720961 cgaatgtaac aacatttcac tatgcatgcc gcaacacctc gtgtttctat caaactgtgt 3721021 aaattcttta caatacagac tattttcata ttacatgatg ggtcatattg gataaatagg 3721081 taaaaaggat tgtcttgaga ggtatagaac tggttctaaa ttgctaaaaa tacgatctca 3721141 tcaccctatg aaaggagaaa acaatcatag tagggacttt ttatttaagc ctttaatctc 3721201 tcctccagtt ctaatttttc ctcccactta actgtttctt atagtcaata aagctcataa 3721261 aaaaacacct tccctcgaag gcgcttctcc atcttattta gatccccata cagcctcacc 3721321 gctggtattc agcacactaa acgtcatgac gttcttctct ctcaccgaat cccactggcg 3721381 taaaaatacc ccgttatact tcttgcctgc taacgtgatg tcggcggtgt tttttccggt 3721441 tttcctccat gttccggtca tttccccgga aatggtgtgg tttttgttga gctggatgtt 3721501 gatggtttgt ttgatgtcgg ctgagatgtc ttttccgtgc tggataagtt tgtatgttcc 3721561 tgtgatgtct ttttgtttta cttctttcaa tgtttcgccc gcataacgat atggtgctgc 3721621 taccggccag ccgtctttgt tcatgaacaa ttggtggact ctgacttcgt gttcttcacc 3721681 cctgcccggg aagcgggtgt ggaagattaa ataggaacgc ccggtttttt catcatagta 3721741 tgcggagttg tggcctggtg agacgtaccc ggtgcctttt tcattttctg tttcaaaagt 3721801 gtagctgccc atgagtttga cgccgtatgg ttcgatggaa cggtcgtcga agaatgtgcc 3721861 tcccttgccg cggacgtcga gcattggatt gccttctgca tcatagtaag ggccgtccgg 3721921 tttcttggag cgggccacac ggatgttgta gccgcctgtt gcatcgagac cgccatatga 3721981 taggtataag tagtagtatt gggtgtctgg attgtagaga acatacgggc cttcgattct 3722041 gctgtggttg ccgccgagca gttttttccc atatccctgt ccaggaagcg ggaagcccgt 3722101 tttcggattc atttcaagta tgaaaatgcc gcctgagtat gatccgtaca ccatccacag 3722161 cttgccgtct ttatcaaaga aggtatgcgg gtcgacgaca ttcggatgtt tggttgcatc 3722221 atacggtgtt ccatcgctgc ttgtgccttc cattcctgat ttcaaaaaga tgcctttgtt 3722281 tttgtatggg ccttcgatgt tgtcagcaac ggcaacaccc atggcggatc ttggcgaatc 3722341 gccgcggcag gcgttgtagt acatgtagta tttgccgtcc gccagctgcg tgacgtcagc 3722401 cgcccaaaga gtatcggatt gcgcccattc gaaggtttct tttaattctt catagacatt 3722461 cgggataagt gggttgtcat tgcttacgct ggtggtcagc tgctgccatt gcatgaggtc 3722521 attcgattta gctgaagcga gatgagatcc aaaaacataa aaagtgccgt ttgtttcaat 3722581 gatggaaggg tcatggacgc tgacttcttt aaatataggt ttttgtgcat agacggagtt 3722641 tgggagggtg aaggccatga taagagctgc aagaaaacat acacggaaca atcggttgaa 3722701 catctaaaca attcgcctct cttttttatt aaattttaaa cgcttacatt tctctatgaa 3722761 gataccccgg cctattaaaa cagccgaatg ttttcatatt catccagata ggtgatttct 3722821 cacttcactt acatagtcag actgatgtct gtctgttttg cgcagaactt gttgcttgca 3722881 tatcctctcc ttcatagttc aactcttttg ctgtttctcc ttcttgcatc acgtctgttt 3722941 ttctttcgcg tacatgtaat aactgctttg tcaggttttg catcaactgt gatacagcca 3723001 tttcgttgtc ggcgtttttt aagatgatgc ctgattgccc gtcaacacca gagtcattcg 3723061 gctggctctt tataaaacgc cttgcgaaaa atacgactta gtaaacgcat attgagagtt 3723121 agacagcggc gcttgcctcc ttgtctggat atcgtgtgca atcgctgaaa aaacctgttc 3723181 tgctttctgc gtcacgctat tacaatagca atctaacttg ttaaagacta taaaaaaacc 3723241 ttttgacttc tgctgctgaa ccaattaata taatactcag ttaatagtta tcagaatttt 3723301 taggaattga gtgattcata tgacactgca taaagagcgt cggatcggcc ggctgtctgt 3723361 tctcctgctg ctgaatgagg cggaagaaag tacgcaggtt gaggagctgg agcgagacgg 3723421 atggaaggtc tgtcttggca aggtaggatc aatggacgca cataaagtag tagccgcaat 3723481 tgaaaccgct tccaaaaaga gcggtgtcat tcaatctgag ggttatcggg agtcacatgc 3723541 gctttatcat gcgacgatgg aggctttgca tggcgtgacc agaggtgaaa tgctgctggg 3723601 atcgctgctt cggacggtgg gattgaggtt tgccgttttg aggggaaatc cttatgaaag 3723661 tgaagcggaa ggcgattgga tcgctgtctc gctttacgga acaatcgggg cgccgattaa 3723721 aggtcttgag catgaaacat tcggcgttgg aattaatcac atatgaaaca gcccatagat 3723781 cttagacgat agggggctat gcgtgaaaac agaagttcac agcatagctc ctttttgtat 3723841 gggcgcttta ccaaagtaaa gaaaaaggag ttgggcttat ggtgacttta gacggttctt 3723901 cattgacaac agccgacgtc gctcgtgtgc tgtttgattt tgaggaggca gcggcttctg 3723961 aggaaagtat ggagcgcgtg aaaaaaagca gagcagcagt ggaacggatt gtacgcgacg 3724021 aaaagacaat ctacggcatc aacaccggat ttggcaaatt cagcgatgtc ctgattcaga 3724081 aagaagactc ggcggcgctg cagctgaatt taatcctttc tcatgcctgc ggagtcggcg 3724141 acccttttcc tgagtgtgtt tccagggcaa tgctgctttt gcgcgccaat gcgctgttaa 3724201 aaggcttttc cggtgtacgc gctgagctga tcgagcagtt gcttgctttt ttaaataaac 3724261 gcgtccatcc tgtcatccct cagcaaggat cacttggcgc aagcggagat ctggcgccgc 3724321 tttcccactt ggcgcttgcg ctgatcggac aaggagaagt cttttttgag ggggaaagaa 3724381 tgccggcaat gacaggcttg aaaaaagcag gtattcaacc ggtaacgctg acatccaagg 3724441 aagggcttgc cttgattaac gggactcagg ccatgactgc aatgggggtg gtcgcctaca 3724501 tcgaagctga gaaactagcc tatcaaacag aacgaattgc cagcttaacg attgaggggt 3724561 tgcagggaat tatcgatgca tttgacgagg atattcactt agcccgcggc tatcaggagc 3724621 agatcgatgt cgcagaacga attcgctttt atctatctga cagcggcctg acaacctccc 3724681 agggagaact gcgggtacag gatgcctatt cattgcgctg tattccgcaa gtacacggtg 3724741 cgacttggca gacactagga tatgtcaaag aaaaattaga gattgaaatg aacgcagcta 3724801 cagacaatcc actcattttc aatgacggtg acaaagtgat ttccggcgga aactttcacg 3724861 gacagccaat cgcctttgcc atggattttc tgaaaatcgc aatatcagag cttgcgaata 3724921 tcgcagagcg taggatcgaa cgacttgtga atccgcagct gaatgacctg ccgccgttcc 3724981 tgagccctca tcccggtctg caatccggtg caatgatcat gcagtacgcc gcggcctcac 3725041 tcgtttctga aaataaaaca ctggcccatc ctgcaagtgt ggattccatt ccgtcatccg 3725101 ccaaccaaga ggaccatgtc agcatgggaa ccatcgccgc tcggcatgct tatcaggtga 3725161 tcgcaaatac aaggagagtc attgcgatcg aagccatttg cgcattgcag gctgttgaat 3725221 acagaggcat agaacatgca gcgtcctata cgaaacagct ttttcaagaa atgagaaaag 3725281 tcgtgccgtc cattcagcag gaccgtgttt tttcctatga cattgaacgc ttgactgact 3725341 ggctgaagaa agaatcttta atacctgatc atcagaataa agaactaagg gggatgaaca 3725401 tatgactgat gtaaaaaaat caatccgtgc caacagagga acagagcttg aatgcttagg 3725461 atgggagcaa gaggcagtgc ttcggatgct tcgaaacaac cttgatccag aagtcgccga 3725521 gaagccggag gacctcatcg tatatggcgg gattggcaaa gccgcacggg attgggacgc 3725581 ttttcacgcc attgagcatt ccttgaaaac attaaaaaat gatgaaacat tgctcgtgca 3725641 atccggaaag cccgttggca tgttccgtac acacccgcag gcccctcgcg tgctcctagc 3725701 aaattctgtt cttgttccga agtgggcaga ctgggagcat ttccacgaac ttgagaaaaa 3725761 agggttaatg atgtacggac agatgacggc tggcagctgg atttacattg gctcacaagg 3725821 catattgcaa ggaacctatg aaaccttcgc tgagctggcg cgacagcact tcgggggcag 3725881 cttaaaagga acgttgacgc tgacagcggg tctcggcgga atgggaggcg cccagccgct 3725941 gtcagtcacg atgaatgaag gcgtcgtgat tgccgtcgag gttgacgaga aacgcatcga 3726001 caagcggatc gaaacaaaat actgcgatcg aaaaacagca tcgattgagg aagccttagc 3726061 ttgggctgaa gaggcaaagc tggcaggaaa acctttgtcc attgcacttc tcggaaacgc 3726121 agctgaggtg catcacacac ttttgaaccg aggcgtcaaa attgatattg tgacagatca 3726181 gacatctgcc catgaccctt taatcggtta tgttcccgag ggctattccc ttgatgaagc 3726241 tgaccgtttg cgtcaagaca ctccagagct ttacgtgcgc cttgcgaagc aaagcatgaa 3726301 aaaacatgtc gaagccatgc tggcctttca gcaaaagggc tctattgtat ttgactacgg 3726361 caacaatatc cggcaagtcg caaaggatga agggctggag aatgccttcg attttccggg 3726421 gtttgtccct gcctacatcc gccccttatt ctgtgaagga aaagggccgt tccgctgggc 3726481 ggcgctttcc ggagatccgg cagatattta ccgtacggat gcgttattaa aagagctgtt 3726541 cccgacaaat aaagcccttc accgctggat tgatatggca caggaaaaag tcaccttcca 3726601 aggcttgccg tcccgtatct gctggcttgg atatggagaa cgaaaaaaga tgggcctcgc 3726661 cattaacgag ctggttagaa ccggggagct aaaagcgcct gtcgttattg ggagagatca 3726721 tttggactgc gggtctgtcg cctctccaaa ccgggaaaca gaagcgatga aggatggaag 3726781 tgacgctgtc ggtgattggg ctgtgctaaa tgcgcttgtc aacacggcgg cgggtgcaag 3726841 ctgggtttcc ttccaccatg gcggcggcgt cggaatgggc tattcccttc atgccggcat 3726901 ggttgcagtg gccgatggaa gtgagctggc tgacgagcgg ctcgcgcggg tcttaacgag 3726961 cgacccagga atgggcatta tccgtcatgc ggatgcgggt tatgaacgtg ccgttgaagt 3727021 agcgaaggaa caggacatta tcgtgccgat gcaaaaataa aggagtgatg acatgccaaa 3727081 gcaaattgat acgattctca tcaacatcgg tcagcttttg acgatggaaa gcagcggtcc 3727141 gcgggcaggc aaaagcatgc aggatcttca tgtgatcgaa gacgctgttg tcggcatcca 3727201 tgaacagaaa attgtgttcg ccggacaaaa aggggctgaa gccggttacg aggcagacga 3727261 aatcattgac tgttcgggac gccttgtaac gcctggcctc gttgatccgc acacccatct 3727321 tgtatttggc ggatctcgtg aaaaggagat gaaccttaag cttcagggca tttcatattt 3727381 ggatattctg gcgcagggcg gcgggattct gtctacagtc aaggatacca gggcggcttc 3727441 agaagaagag ctgctgcaaa aagcccattt tcatctgcaa agaatgctgt cctacggcac 3727501 aaccacagca gaagtgaaaa gcggctacgg cttggaaaaa gagacagagc tcaaacagtt 3727561 gcgtgtcgca aagaaactgc atgaaagcca gcctgttgac cttgtttcca catttatggg 3727621 agcccatgcg attcctcccg aatatcaaaa cgatccagat gattttctgg atcaaatgct 3727681 ttcccttttg ccggaaatca aagagcagga gctcgccagc tttgctgata tttttacaga 3727741 aacaggcgtt tttacagtca gccaatcccg ccgttattta caaaaagcag ctgaggcagg 3727801 cttcggatta aaaatacacg cagatgaaat cgatccgctt ggaggtgctg aattagcagg 3727861 taagctaaag gccgtctcag ccgaccattt ggtaggtaca tcggacgaag gcataaagaa 3727921 attggctgag gcaggaacga tcgccgtcct cttgccgggc acgacatttt atcttggcaa 3727981 aagcacatac gccagggcaa gagctatgat tgatgaaggt gtatgtgtca gcttggcaac 3728041 ggattttaat cctggcagct cgccgactga aaatatccag ctgattatgt ccattgccgc 3728101 gcttcatctg aaaatgactg cagaagaaat atggcacgcg gtcacagtca atgccgcata 3728161 tgccatagga aaaggagaag aagccggtca gctcaaagct ggccgctcag ctgatcttgt 3728221 catttggcaa gccccgaact atatgtatat tccgtatcac tacggggtca atcatgtaca 3728281 tcaagtcatg aaaaatggaa caattgttgt caacagggag ggagccattc ttggataagt 3728341 acccttttct cagagaggcc ggatcttcgt ttaaagaccg ggatgtcaca aaaatgagcg 3728401 acctgatcgc aacatgggac ggccaggaca ttaagggacc ggcgttgata ggtgtccccc 3728461 tatcaaaatc ctccatcagt cattcaggcg cttcctttgc acccggaaca atacgccagg 3728521 ctctgaaaca ttcatcagcc tattctgctg agcttggaga gcacgtcgta tcagagcttc 3728581 tatatgacct gggggatatc gatattcatg tcactgatat cgtaaagtca catcatcaca 3728641 ttttccaaac catgcacgct ctgctttcgg atcatccgga ttgggtgccg ctcatacttg 3728701 ggggagataa ctctatcagc tactccacaa taaaagcgat agcacaaaca aaaggaacga 3728761 cagcggtgat tcaatttgat gcccatcacg atgttcgcaa tacggaggac ggggggccga 3728821 caaacggcac ccccttccgc cgccttttgg atgaagagat cattgaaggt caacatttga 3728881 tccagctggg tatcagagaa ttcagcaaca gccaggccta tgaagcatat gcaaaaaaac 3728941 ataacgtgaa cattcacacg atggacatga tccgggaaaa aggactaatc ccaacgataa 3729001 aagagatttt gcctgttgtt caagataaaa cagatttcat ttttatatct gttgacatgg 3729061 atgtcttaga ccagtcccat gcacccggct gtccagcgat tggcccgggc ggcctctata 3729121 cagacgaatt gcttgaagca gtcaagtaca tcgcacaaca gcccaatgtt gccgggattg 3729181 aaattgttga agtcgaccct accctcgatt ttcgagatat gacaagcaga gctgcagctc 3729241 atgttctgtt acacgcatta aaaggaatga aactctcccc attcaagtga tcttctggca 3729301 ggttgtattt tgggtataag aaactcatct gcctaaggaa tggcagctaa aaggagggcg 3729361 agacagtgaa tcttcaggag aacagcagcc aacagctaaa acgcacaatg aaaagcaggc 3729421 acctatttat gatctcattg ggaggcgtca taggcacagg acttttcctc agtacgggct 3729481 atacgctaca tcaagccgga cccggcggta cgatactcgc ttatgtaatc ggcgggttga 3729541 tgatgtacct cgtcatgcaa tgtctcggcg aattgtcggt tgccatgccg gtgaccggct 3729601 cttttcaaaa atatgctaca acatttatcg gtccatctac cggttttatg gtcggcatca 3729661 tgtactggat caattgggtg gtgacggtag gctctgagtt taccgcatcc ggtattctca 3729721 tgcagcgctg gttccctgac agcagtgtat ggatgtggag tgcgattttt gcagcccttc 3729781 tttttatatg caacgcattt tcagttaagt tatttgcgga aactgaattt tggttttcca 3729841 gcgtaaagat tgtcaccatt attttattta tcattttagg aggagccgcc atgtttggcc 3729901 tgatctcttt aaacggaacg gcggatgctc ctatgttgtc aaacttcaca gatcatggcg 3729961 ggttgtttcc aaatggcttt ctcgccgttt ttatcgcgat gatatctgtg agcttcgcct 3730021 tttccggtac agagttaatc ggcgttacag caggagaatc agcaaatcct caaaaggata 3730081 taccgcgatc catccgtaat gtcgcatgga gaaccgtgat ttttttcatt ggcgctgtct 3730141 tcatattatc cgggttgatt tcatggaagg acgcaggcgt gattgaaagc ccgtttgtcg 3730201 ccgtatttgc ggagatcgga attccttacg ctgctgatat tatgaatttc gtaatattaa 3730261 cagccttgct gtctgtcgcc aactcaggct tatatgcttc gacccgtatg atgtggtctt 3730321 tagcaaatga aaacatgatc agctcccgtt ttaagaaagt gacatctaaa ggcattcctt 3730381 taaatgcctt aatgatcagt atggctgtat cttgtttatc tctcgtttcc agtatcgtgg 3730441 cccctggaac tgtctatgtg gtgatggtcg caattgctgg atttgcagga gtcgtggtct 3730501 ggatgagcat tgccttgtcc caactcttgt ttcgaaagag atttttgaaa aaaggggggg 3730561 atgtaaaaga tctgacattt cgcacgccgc tttatcctct tatgcctata gccgctctct 3730621 tattatgttc tgcttcttgt atcggtcttg cttttgatcc caatcaaaga atcgcacttt 3730681 tctgcggagt tccttgtatc atcctttgct atctcatcta ccatttcaaa agaaatgtta 3730741 caaaagcgaa aaaaatcagc caagaggaat atccagccga tcacatccta taattaaaaa 3730801 agcacacccc gctcagcatg ggatgtgctt tattttttat tctgtaatta acgtatgaat 3730861 cagcttcggc gccttcgctt ccgcggcgat gcggatgttg tcatagactt ttgcgatgac 3730921 ttcatcgacg ttttctcggt tagcgtaaag cgttacgagc ggttcccctt tttctacttt 3730981 gtcgccgacc tttttgcgga gcatgatgcc gacggctaaa tcgatttcgt cttcttttgt 3731041 ggcgcggccg gcacctaaca gcatcgccgc gacgccgatt tcgtccgcga cgatttcaga 3731101 gacgacaccc gcttctttgg caggcacatc aatttgatat gcggcttgcg gaagcttaga 3731161 cggatcgtca acaattgagc tgtcgccgcc ttggtttttc aggaaatcct tgaatttctc 3731221 aagtgctttg ccgtttttca tgacttcttc cagcttcgct ctcgcttcgt ccaatgtatc 3731281 ggcttttttc gcaagcacaa ccatctggct gccgagcgtt aagacaagct catgaagatc 3731341 ctcaggcccc tcgcctttga gcgtgtcgat cgcttctttg acttcaagcg catttccgat 3731401 cgcaaagccg agtggctggg acatgtctga aatgacagcc attgtttgac ggccgacgtt 3731461 atttccgatg cgtaccatcg ctttggcaag ttcagctgcg tcttcttctg ttttcatgaa 3731521 ggcgcccgct cccgttttta cgtcaagcac gatggcgtcc gccccggcag cgattttttt 3731581 gctcataatc gagcttgcaa tgagcggaat ggaattgacc gttcccgtta catcacgaag 3731641 cgcgtacagt tttttatcag ccggcgttaa attgccgctt tggccgatga ccgcaacctt 3731701 gtcgcggttc acaagtttaa taaattcatc cttcgtcagt tccacgtgga agcccatgat 3731761 tgcctctaac ttatcaatcg tgccgcccgt atggccgagg ccgcggccgg acatcttagc 3731821 aaccggcaca tcaagagccg caacaagcgg agcgagaacg agcgttgtcg tgtcgccgac 3731881 gccgccggta gagtgtttat ccactttaat tccttcaatg gcagaaagat caatcgtttc 3731941 accggagttc accatagcca tcgtcaagtc cgcgcgttca cggtcactca tatcctggaa 3732001 gaaaatcgcc atagcaagcg cgcttgcctg ataatcagga atgcttccat ctgtatagcc 3732061 gttcacaaaa aattgaattt cttcagtggt gagttctttt ccgttttgtt ttttgatgat 3732121 gatatctacc attctcatgt ttggtcaccg atccttttcg attaagttca gtaaatcaag 3732181 cccacaattg ctgctgataa aaagctgaca agcgtagcac cgtataataa tttcaagccg 3732241 aaacgagcga cgacatttcc ttgcttttca ttcagtcctt ttacggcacc ggcaatgatt 3732301 ccgattgagg agaagttcgc aaatgacaca aggaataccg atacgatcgc tgttgtacgg 3732361 ccgctgaaat ggaaaccgtt ttgcgtaagc gacgtcatgg cgacaaattc attcgatacc 3732421 atttttgttg ccataatgct tcccgcatta acagcttcat tccatgggat accgacaaga 3732481 aaagcgaatg gagcaaacac atatccaaga atgccttgga acgaaatacc gaatactgca 3732541 ttaaaaatgc cattgatcaa tgcaataatc gcgacaaatc caatcagcat cgcagcgacg 3732601 acaaccgcta ctttgaaacc gtcaagaatg tattctccga gcacttcgaa gaaggattgt 3732661 ttttcttctt cctcaacacg aagcatatcc tcttcttttg caacctcgta cggattgata 3732721 atagaagcga taatgaaacc gccaaataag ttcaaaacaa gcgctgttac aacatattcc 3732781 ggtttcagca ttgtcatata cgcaccgaca atcgacattg atacagttga catcgcagat 3732841 gcgcaaagcg tgtacaagcg ctgctgattt aaaagaccga gttctttctt caaggagata 3732901 aatacttctg actgccctaa aatcgcagaa gccactgcgt tatacgattc caatcttccc 3732961 ataccgttta ccttgctgag ggcaaggccg atatatctaa tgataaacgg gaggactttc 3733021 cacttttgca gaatcccgat cagagcggaa ataaacacga ttggcaagag aacattcata 3733081 aagaatgtcg tttggtccgc attcaccaag ccgccaaaca caaagttaat tccctctgcc 3733141 gcgtattcaa gcaggtaacc gaatcctttt gcaaatcctc ccacgaggaa attccctatt 3733201 ccggtattga ggagaatgta gccaagaata aattgcaaaa tgagcataac aacaattggg 3733261 cggatcttaa ttcttttttt gccgctgctc gcgatccacg cgaggcctaa aaacacgatt 3733321 aaaccgataa tcccaatcaa atacttcata tgtgtttctc ctttatttgt attcgcttac 3733381 aattactgtt tcctcagaaa acggaaagca gtctgccttc cgtcagctct taatagttgt 3733441 ctccgcctga tgcattttct ccttttacga tagaaacgcc tgcgctggcg ccaattcggc 3733501 ttgctccggc ctctaccatt gtgtctacat cttctttcgt tctgacgccg ccagatgctt 3733561 tcacgccgat atcaggccct actgttttgc gcattaaggc gatatcttcc ttcgttgcgc 3733621 cgcctgtaga aaagcctgtt gatgttttta cgaaatccgc tcccgcagac accgctaaac 3733681 ggcatgcacg ttctttttct tcatcagtca gaaggcacgt ttcgataatg actttgacaa 3733741 gcgcttttcc ggctacagct tccactacac cgcggatatc agcttccacc acatcgtctt 3733801 ccttgtcttt taaagcggca atattaatga ccatatccac ttcagtggcg ccttttgaaa 3733861 tggcgtcttt tgtttcgaac gcttttgttt cagttgtatt ggcaccgagc gggaagccga 3733921 tgaccgtaca aacgtcgact ccagttccct taagctcttt tgcagcaagc tccacccatg 3733981 tcggattgac acatactgaa gcaaatttgt atgttttcgc ttcttcaatt agttttagaa 3734041 tgtccgcttt ttgtgtatgc ggtttcaaag ctgtatgatc aattatgttg gctaatgaca 3734101 tccttcgcac acttcctttt ttgttaagat attttttagc ataaccgact tttgaacata 3734161 tgtaaattgg taattgaaat tttgttcaat gaaaggtttg aacgtgtcac aaatcattaa 3734221 caagcgccct cgcggtatgc tggtcaatga ttaaaacgtt ggcatatttt ccggttaatg 3734281 ctccgtgaat ggaagatact tttctgcttc cgccggcaac taaaatggag cgttccttca 3734341 gtctaaggtc ttgaagctca acaccgatgg tccggtcatt gatggcgctg ctgcaaatat 3734401 tccctttcgc atcaaaaaag cgtgaacaaa tatccccgac ggcctgtttt ttcagcaggg 3734461 ctttctcttc ttcgttaaaa tatccgagcc gaaacaacag cgcttcatca cggacagtcc 3734521 cgaccgtaaa gagagcgata ttcgcctgct tgcccatctc aatgatccgt tcaatatgac 3734581 ggtctttctc caccattcgc ttcacatccg cattatcaaa cacgacggga agcgggagat 3734641 agcgcggcat cgtttgaaaa gcctctgcaa acagctgaat cgtttcagcc gaatacgtgt 3734701 ttacccggga atggctgatg ccgcctttca gctggacgac ctcgacgcct tttacctgct 3734761 tcggctgcat gttttgcgcg atttgataca tggtggttcc ccagctgacg ccgacaatgt 3734821 cgccgtcttt taccgtttca tgcatatatt ctgcaccata gcggcttagg tcatgtgtaa 3734881 ttcctgcata atcgggtgtc ggggaaaaca caacatgcgc ctcaaggagc ccgtatttct 3734941 cttcaagtat ggaaccgagc gcatccaaat cctcaaaagg gtccatgacg cgaatctgga 3735001 catacccttt ttcctttgca tattgcagca gccgggaaac ggttggcctt gaaatgttga 3735061 gctgctcagc aatttgctgc tgactgtagt cagactgata gtaaagcctt gccgcttcta 3735121 tgcttaattg ctgtttttcc cgatccattc tgcacctccc tgtggatcag tcctgataaa 3735181 actgcttttg atttgctttt attatacagg ctggcgccgg ctttcatcca cctgatttct 3735241 aagaaactga aaaacgctct gggcgcggac ctgcccagag cttacttctc ccaagtcata 3735301 tgctgataaa tgcctttcat aatggcgtac attccatata ggatcaggcc taatgccaat 3735361 atagacagaa tcaatttgcc atgcggctgc tgcgcgagtt ctgcgagcgc gccgtcaaag 3735421 cctcttgtgt cgtcgggatc agcggtcatg gctgtcttga tgagaaaata gccgatagcc 3735481 gagaaaataa tggcccgggc gatattgcct gcgcgtcctg tgtttttcgt gatgcatatc 3735541 atctgtttgt tcatttttga tgtatcgaat tctttcataa aagcagcccg aacgcctttc 3735601 ataaattgaa caatcgcaaa tacgataaaa cccgcacccg taagccctgt gagccattgg 3735661 ccgaacggct gcgccaatac ataagcggac cacgtctgtt ctgaagtgcc gccgtcccct 3735721 tggccaaaca caaatcgcaa ggcattccaa gcgatggatg tgtaaacagc ggcactgaaa 3735781 aagtttccta ttctccgcga caggcctcgc ctgctgtttc cgtgcccctc cgtgtccttg 3735841 atcgcgctta acaccatcca gatcacatag ccgataaggc cgatgcctat aaaaaaaagc 3735901 aatagtgacc catacggcat gcgtgatagc gtttggagag ctccgctcga atctttggcg 3735961 cggcctgccc cggcagccgt cataaaagcc aaaaccccaa gcagaataaa aacgccgccg 3736021 aatgcaaaat aaccaagcct cccgaatcgt ttgatccaag gcttggtttc ctgttttatt 3736081 tttgacatgt accggtcttt caccgccatg tgtccaaccc tctttcacag aaatctttac 3736141 tgtaacattc ccgattgaac aaagttgaaa cagctcctgc ctcagctatg gctggctgag 3736201 atacgttttt gctgtttagc tgattgtgca ggtgtcatcc aagcagccgc tgcggcagct 3736261 gtgactccgc ctgctaattt cccaatgatc atggccgccg ccatttcttt tttcattcca 3736321 gctacaaaac cgagatggct gccgagtaca aaggcgccgc tgaccgcaaa cgcgacattg 3736381 atgacctttc ctctcggcgt catatccttt aatgaagcca gcattgggat atgatgcgcc 3736441 aaagaggtca ctaagcctgc tgttgctgtc tcatctaaat gaaggcattt ccccagagcc 3736501 tgaagcggtt ttttaaaggt ttttgtaata aatgccgtca tcgggaacgc ccctgccaga 3736561 gcaatggcga tggtccctgt cgtttgtatc cctgtctcga cattctccat tcccggaatc 3736621 agcacaatgc cggtcatcgt ttcaacagaa acagctgcaa gcccgataat cgcaaccata 3736681 ctgaccgctt tcccgaagag atgaaacaac tgaatcattc tgtcggtgta tcgccataac 3736741 ccaaaagcga tgacagcaga taacagactc gggatcagaa gatttttacc tatcatgccg 3736801 atgtcaaagc ctgcgcataa tccgccgatt aagcaaccga tcggcactgt gcacagcccg 3736861 attaatatgc ctttcgcaaa atacggatga tcctcttttt cgatgatgcc aagagcgacg 3736921 ggaatcgtga agacgattgc cggccccatc attgttccta aaaacaccca tgaaaacagc 3736981 ccggcctgcg gatctttcgc catttctcca gccagcgcat atcctcccat atcaatcgcc 3737041 aaaatggtgt tcgcaaagga agaaggatcc gcgccaatcg ctgtgtaaaa cggagcaaca 3737101 atgggaatca agattgctgc cagcacgggc gccagcgata caattccgat catggacagc 3737161 gccagcggcc ccatagcctt aaagccgtcc gcaaaccgct cgcctagccc ccatctgttt 3737221 cccaaacaat aatccgctgc tccccatagt aaaaaggcag ccaaaatgaa tacaaccgcg 3737281 tcattcaccg tcatggtttt ctcctttttc aaacgtatga ttggttttat catatcatct 3737341 gaaatcaccg aatagagttg atcttattca atatgagcta aaaattcttt tatatcggct 3737401 ttttcaacgg ctgttataat gcgtcgcgct ttttcttgcg ggaccgttaa tgtcaatttt 3737461 tctattatgt cttcttcaga cagctcattt cctggtgccc cttttgggca gtccacacgc 3737521 gcttcgcaaa tccggccgtc tgataaatag gcccggacaa tcgtgaaacg gccttttgga 3737581 acggcatgag gagccggctg aatagcattg tcatatacgc gctgaattcg ccccattgtc 3737641 gtttgaaccc cgtttgggat cggctggctg ctgaaatgtt caacggtcag gccgtgtcca 3737701 tgcaaagcaa gagcaatcac atattcaacg ctgaaacggc cttcctctcc agcttttgga 3737761 gatctttccg tcaatgcagc atctccgcct ggcggaaata tcacttcaat acgttcggta 3737821 ttggcagcag aaatggtttc ttcggagata agctgtcgta ccgcatctgc agcatggtgt 3737881 gccgcggaac aaaatggata gattttaaac catagacccg gctgcacaat tctccacggt 3737941 gccccccaat cgtttagcaa agtgtgttgt gctttctcaa cgtcaccgta cagactgaag 3738001 aaaccagttt ctccatcaag tgccgtgcgg gacccgccaa attctgattg ggccagctta 3738061 acggccagca agccagcctg agccgccaaa ccggcgtgca gcggtttcat ttctgttcca 3738121 aattgcaccc tcatcccagc agattgcgta gccgcaaaac caattgcttt ttccaactct 3738181 tcctgagtca gctcctcagc ataacctacg gcgcaggcag cagcgatggc accaagcgta 3738241 cctgtattat gccagccctt ctcatagtgg cggctgccaa ttgattctcc cagccgtgcc 3738301 atcacttcaa caccaacaac ataagcgcca agaagccgct cgtcatgtcc gcgagcggca 3738361 gaagcaataa gggccggtac gatgactgca ctggggtgtc ctcttacatc ggagtggaca 3738421 tcatcaaaat ccaatgcatg ggcgataaat ccattgagca tcgcggattg taatggcgcg 3738481 gcctttttgc cctgtccgat aacaggaaca aggggccggc ctccttcatc ctctatcaga 3738541 cggaggagct tttgaattcc tttatcttct cttcctgcga atgaagcggc agtaaaatca 3738601 agtaatccct tttttgcttc gtgaatcgcg tcaactgaat gctcaggttg tgacgttctc 3738661 acagcctctg caagacctgc tgtcagccct tgtttgctca tttgatggtc tccaatacaa 3738721 taaccgccag ctccgcaaag tattgagagg caaccgtaag ggcttcttca tccagtgtaa 3738781 aggccggatg atgccactcc tccgtcccgt tcgttcccat ccagacaaaa aatcccggaa 3738841 tcttctcttg atacagagcg aagtcttctc cgcccggaga ctgctcagcg tgaacggttt 3738901 gatagccaag ccgtgccgca gcttcggatg ccgcattcaa aaatgtgccg tcattctgaa 3738961 cggaaggcaa ataaggaaac cacttgaatt ctgcttgtgc cccatagccc gctgcaattc 3739021 cttcagccac tcgtctcata tgctcgggaa cagcctgcct cgcttctttt tgaaaggttc 3739081 gaaccgtccc ctccatttca gcttggtctg gaattacgtt ccacgaggtg cccgcctgta 3739141 ctcttgtgat actgacgact gcgttttgca gtgagctgat attgcggctg accacagatt 3739201 gcagcccgct gatgatttgt ccggctgcag cgattggatc aatactgtta tttgggatgc 3739261 cggcgtgccc gcctttccct ttgatgacga tctcaaatcg gtcaacactt gccatgagcg 3739321 gaccttcctt tacaccaatg gtcccgacag gcagatccgg cttattgtgc atgccgaaaa 3739381 tcgcagaaac gccattaagt acgccagctt ctagaacctt tcttgctcct gcggcaattt 3739441 cttcggccgg ctgaaagata aagcggactg tacctttcag ctcggccctt ctttgattca 3739501 gcaacatcgc tgtgccaata atagaagcag tatgaaaatc gtgtccgcac gcatgcattg 3739561 tgccatcaac cttagatgca aatggaagat tcgtctgttc ttggatcggg agcgcgtcaa 3739621 tgtccgctcg tattgctatc acggggccgt cttcccgtcc tttgatttct gcaatcacac 3739681 cagtcttcaa ttgagggaca tcaagtattt cgatttgctc ctcctcaagc caacggcgga 3739741 tttttttcgt cgtttcaacc tcttgaaatg acagttcagg atgttcatga agatcacgcc 3739801 gcatattgat taaacgggta tgaaacgctt tgtcggccat tgttcttctc cccttcttat 3739861 ataagctctg caggctctcc cacctgcttg ataaatcgtt tcgtccgttc gtttttcgga 3739921 tggtcaaaca gttcctctgg cgttccctgc tcgataatat ggccgtctgc cataaaaatc 3739981 acttgatcag caacctcttt tgcaaacgcc atttcgtgtg taacaatgat catcgttgtt 3740041 tgtttttccg caatggactt gatgacctga agcacccctg tgacgagctc agggtcaagc 3740101 gctgacgttg gttcatccag caaaatcgca tgcggattga ccgcaagcgc ccgcgcaatg 3740161 ccgattcgct gctgctggcc gccggacatt gtgattggat agctgtcagc cttatgctcc 3740221 agaccgactt gtttcagaat ctccattcca atacgtttcg cttcgtcgcg tggtttatgt 3740281 tgagccacga ttaaagcttc tgtaatgttt tgcagagccg ttttattttt aaacagattg 3740341 tagttttgaa agaccatggc cgtttgctgg cgaagccgat gtgcttcctt gcgtgtaaac 3740401 ttttccgcat tcagtttggc ttctccgatt tcaataaggc cttgatccgg acgctctaat 3740461 agatttaagc accggagaag cgttgatttt ccggaaccgg acggaccgat gattgccacc 3740521 acttctccgc gtttcacttc tagatcgatt ccgtcgagca cgacgagatc tttaaacgct 3740581 ttgcgaatat tttttactgt tatcaactga tttcacctct aagtccggta tggcttgctc 3740641 atggcacgtt caaacaagtc ctgcaaaatg ctgtagataa tggtaagaac ccaatagacg 3740701 atcgcaaccg ccaaatacgt ctcaaaatat ttgaggtttc ctgaagcgta catcttccct 3740761 tgggcgaaca tctccatgac ccctaatgta aaggccagtg acgtttcttt caggagcccg 3740821 ataaatgtat tgcccgttgc cggaatcgca tttcggatcg cttgcggcaa aataatccgt 3740881 ctgtatgcct gaaattttgt cataccgaca gacaggcacg cctccagctg cccgtcatca 3740941 acagaattga gggcggcccg gaagatttct gccaaataag ctgcgttttt taagcttaac 3741001 ccgatgatgg cagctgtgag agctgtcatt ttgctcatct ctggaaatag ctgcggcagc 3741061 ccgtaataga ttaagaacag ctgtacaagt gtcggcacgc ctcggaaaaa ggatatatac 3741121 agctttgaca gctgatgaag cactggaatt ttgttttttg taatgagtgc gagaataagt 3741181 cctccgataa tggcaaaaat catagctgct attgccataa acaaggtgat cggaagggcc 3741241 tgaattaaag tcgggaacgc tgatatcatg aattcccaat caatcgtgtt cattctggtg 3741301 agtcaccgcc gtttcttaat gcttctgttc tactgtgata tcttcattaa agtatttttc 3741361 agagagtttt ttcagtgttc cgtctttacg caattcatct agggccttat tgactttttt 3741421 gcggagcttg tcgtgcgcat cgtccttggc aaatgggaat gcaacctgtt cgtaaacaat 3741481 cggatctcct gcaagcttta atggcaaacc ggtcttcttg atttgcgcga tcaatacagt 3741541 tcggctgttg acataagcgt ctacacggcc gtacgcaaca tccttcagcg taccctcttg 3741601 tgtttcgtac gttttgatat tgattttttt atcaggatct ttgctttcaa ggtttttcgc 3741661 gtggtttgaa ccgagaacgg ctgcgactgt cttgcctttt aaatcgtcta ctgatttgat 3741721 gtctgtattg tcttttttga cgacaatctg tgttcccgca taagcgtatg gtttcgtaaa 3741781 gttatacgtt tccttacgtt cgtctgtcac agctacctgg ttggaaatgg tgtcaagctt 3741841 gcctgtttga agctctccca tcagcccgct gaattcaagc agcttccagt ccagtttcat 3741901 gtcaattttc ttagcgactg cttccatcac ttccacgtca aagcctgtca gctttccgtt 3741961 ttctttataa gcaaatgggt aactttgtcc tgtcgcaccg acatgaagca cattgtcatc 3742021 ctctttactg ctgctgtttc cattgccgca agctgagagc accgctaata atgcagcaac 3742081 gaccagcact gtccattttt tcatcttcat ttgattttcc cgccttttct atttttatag 3742141 atcatgtcgc aattgttttt tcatatagac tgtgatatgc ccttttccaa ggtcttgttc 3742201 acctgagcgg acatatcctt ttcgttcgta catctcaatc agccacggat gcttatccgc 3742261 tgttccgagt gagacaaacg gaacctttaa cgtatcgcga aggattgttt cctccagcca 3742321 ttgaagcagc tttgttccga ttcctttttt accggtgtcg gggtccacag caaaccacca 3742381 gatatgcgga acgccatacg gtcccggctg ttttccccaa ggcattctca aggtgatggt 3742441 cgcgatgatc cgcccgtctt cttccatgac gtagcaagca ttttcccgaa tatttttcag 3742501 caccaaatcc aaatccgcat gagcagcagc aaaacgaatg ccgagctttc gaatcggttc 3742561 ataagcccgc aatgtcagct cgagaagctg ttcggcatca cgttcaactg caaggcggta 3742621 tcgtggcttc atctagcgtt cctccttact ttgcatagcg gtttaccggc ttttccaaac 3742681 cgaagtgctc tcgtaatgtt gtgccttcat attcttttct gaacacgccg cgctcctgta 3742741 aaatcggaac cacttgatca acaaacactt caattccttc tggaagaagc ggaggcatga 3742801 tgttaaaccc gtcacacgct ttcgtatcca cccattcctg catcttgtcg gcgagctgct 3742861 ccggcgtgcc gacgaagata tggtggcctc tggagcctgc aacgtatttg taaagctctc 3742921 gtatcgtcat attgtcacgt tcagccatct cctgaacaag cttgaagcgg ctcttcaccg 3742981 cattggaagc ttcggcgtca agcttcggca gcggcccatc aagcggatat gccgacaaat 3743041 caattccgcc taagtaattt tggagaattt gcagaccgac agatgggata atcagatctt 3743101 ggagctcctt gtatttggct tgcgctgctt cttctgtatc ggcaatgatt gggaaaatac 3743161 ccggcataat ggcaattttt tctggatcac gtccgaattc cgcagcctgt tctttaatgg 3743221 attgataaaa ttcttgagct gattccaggt ggttttgtgc tgtgaagatc acttcggctg 3743281 ttttggcagc cagcgctttt ccgtctcctg atgatcctgc ctggataatg accggctggc 3743341 cctgcggggt tcttgaaacg tttagaggtc cgcgaaccga gaaatattct cctttgtggt 3743401 tcagctcatg cattttttct ttgtcaaaga attcacccgt ttctttatta cggataaagg 3743461 cgtcctcttc ccatgaatcc caaagcccct ttacaatctc gacaaattcc tctgcccgct 3743521 gatagcgcaa atggtgttca aggtgctttt caccgctgaa attcagcgct gttgattcaa 3743581 tagatgaagt gacgacgttc catccggcac ggccattgga cagatgatcc aatgacgcaa 3743641 actgtctggc aatatggaat ggctcgctgt atgtagtgga ggctgttgct gtcagtccga 3743701 tttttgatgt gacctgcgcc aaagcagaga gcagggtgaa tggctcaaac cttgttaata 3743761 catttggatg tgatttgctg tcaattgaaa ggctgtccgc taaaaacagc atatccagct 3743821 tgcctcgctc cgctgttttc gcaagctctt taaaataatc caaattcatg ctcgcatctg 3743881 acggcgcgtc cgggtgccgc caagacgcaa catgatggcc tgtacctgct aaaaataccc 3743941 ctaatttgat ttgtttcttt ttgcttgtca tggcgatact ccttttatca tgtttttagg 3744001 ctgaataatc cgaaaaataa actcctatat tcctagtcgt ttaatatgaa taaatcaaaa 3744061 tgtacctttg tcttggacgt ttgtcaatga gttaagatta attttttcta ttcaagcgaa 3744121 aagacccttg cgtgaccatg agggaacggc attgattcat tcaactagtg caacctctat 3744181 atcggcaaga aaactgagtc taatgaagca aagactcagt tttcttccaa taatttcata 3744241 taagatttcg ccatttcctt tgccttttct tcgcttttgc aaaccgccta tccattcaga 3744301 cgccgtaacg attgtataaa aaaacagctg actccagata ttcaaaccgg aatcagctga 3744361 ttgatgtgaa ttaattaagc tcatgaatac tctcttctgc tttagcggaa aacactttag 3744421 gctccaaaca gtcaaggtct tcatgaaata aatttacttt ttggatttgc cgattgtcat 3744481 agtggtggaa atagtagttt ccagtttcgt tgcacatcac ggaagtatat tgcgtataat 3744541 gaatttcgtc ttcttccgtt atcactgcgc cctttggtat cgtcatattt gccaaaattt 3744601 gaaaagcggc tgttacacct ttcgtttcat cggccgccgg ctctagatgt tctttcaaat 3744661 aaacagctct gacaaaccgg gaaggcggtg tataatcccc cggcagacca acagttccta 3744721 agccttggcc aaaagcagaa agggctaatc cgcccatctc tttgctctct aattgcttcg 3744781 gtctgattcc tgtatattgc tgcagattgg ttacatgcca tataaagtcg gggctgttcg 3744841 tcatgacacc aggttgatta tcatagactt tgaggccgtc tgctcttggt tctatcgtca 3744901 ggtttcggcc cgtccggtct gacaatatcc agtgaagcgg taaaactgta tccaatagat 3744961 ctaatttttt ctctacaatc gttaaagatc gaatcttttc ttttacgtct tccaaagact 3745021 gacagactga cagcacccat gtcacaaact catgcgggac aatgtgaacg gtatcttccc 3745081 gtatcgtttt ttcgtactcc gcatagcccg gaaaataaag cgccgcacaa gataaaccgc 3745141 tttcattaat gccgtcggca aataatatat ttccaagttt tctccccata ccgataaacg 3745201 cgtactgtgt ctgatgggcc cttccgtcag cttcactgtt ccagctgtaa cggcgcggat 3745261 agagaatcac ctctgtcccc agctgaaatg caaaatccat tgttcttgct aatacatgtt 3745321 tacggtcagc agtttccaat gtaagacttg tgcacatttg atcagtcccc ttttcaattc 3745381 agattaatat catacatatt gtgaacgaat tggttttatc agcataacga aagtcaaatc 3745441 gattcgtcaa agaattgaca ttacatcaaa taaaacgaaa aaatccagcc tttagaaggc 3745501 tggatttttt attatttagc caaaacaagc tcgtgaatcg catgtgcaac gccatgttca 3745561 ttattggagc gtgtttgaaa gtttgctgct tccaatactt ctgggatggc gtttgccatg 3745621 gcaaccccgc agcccgccca ttcgatcatt gtcaggtcgt tcccgttgtc gcctatgcac 3745681 atgacttccg cctgttcaat tccaagcagc tgagccagct ggcgtacagc atttcctttg 3745741 ctggcttccg agtgcagaat ttcataaaag aaaggcgcgc ttctgaccat tgtatatttt 3745801 tctctcacgt cttttggaat cgatgtaatg acgcggctta agttctccgg tttatcaata 3745861 aacatcactt tcgggatgag gatatctttt ggcacctcgt caatcttgcg gaaatgaagc 3745921 ggcacctgtg tcacatagga ttcgtatacg gtaaattcgc taatatcccg gttaggcgta 3745981 tacaaattag atgagtcaaa gaaatgcatc ggcgtcttca gctctaagct caggtcatat 3746041 aatgaagtca aatcatcata accgagagac agctctgaga ccacttcatt tgtatgcgta 3746101 ttttgaacaa gtgctccatt atacgcaata acatagtcgc cttcttcaat taaattcagt 3746161 tcatctaaat atctctgcac acccccgata ggccggccgg tgcaaagcac aattttgaca 3746221 ccttccgctt ttgccgcgtg aagggcgtcg cggacctcct ctgttacttc atgatgatca 3746281 tttaaaagtg ttccatccat atcaattgca attagtttgt acatcctgca tctccttcat 3746341 gtcgttttca ggctatagtc ccatcatatc gttttttctt tttgatattc aaccggaaga 3746401 gatggttttc tccggattct gtttagacgc cgcccttgtc ttcggatacg caagcgcggt 3746461 ttccgctttc tttctgcctt gacgccgttt tctgcttttt tctgtttcat cagcagaaag 3746521 ccggcagcta gaaaaggaat gccggttata ttcaagatgg caagcttcac acccgccgcg 3746581 atgaaaaaga acccccatga agatgatgga ttccgtctga tcatgacgta agccgccatt 3746641 tccagaacga tcaggatggc atgaagcact atgccataaa tcagcaatac aagggcaaaa 3746701 aacaaaacat aattcacgat tgcccctgag tacatcatag cgcgcatcat ttgtataaac 3746761 gataaggact gcatggagcc gctgatgaca ttagggttat agatcgtata gtcactaaat 3746821 aaatgtttga ctttgagaaa agcccataat ataaatatcc attgaatgat atgtaaaaca 3746881 agccccgctg ccaccagtct ttcagctttt tgatttctca tctttctcct ccctgccggt 3746941 ctttgattcg attcttgtca tcgtttttct ctgtccattt tgctcccata tcaatgtccc 3747001 gttttctcct cttttcagcg tgcttttgag cggataataa gggccgaggt actgaatctc 3747061 gatagacccg tcagtgcttt gggaaatcac cttgtatgcc ataaaaggca gctgtacctc 3747121 tcctcttcct tccatcactt ccgtttccac aacctcgtct tcggtaaatg tgactgttgc 3747181 tgatttcaca ccgtccgttg gcccgggggc acgcccctca tcccacgttc cgtaataaaa 3747241 cggcgtctct tctttttgct gctggcagcc cgataccatg atgcatacag caattaaaaa 3747301 caaaatgcca tatttgtttc tcaaggggat caccattctt tcctcctttt ttgggcgaat 3747361 gccgtgccac tgtgccaatg actacataag ttataaggaa ttcacccaca aggagactga 3747421 tcacatgaac ccttatcaat attacagccc tcagctgcct cagcaggaac cttactatag 3747481 ccactatgag tacaatcctt atccgcagca ggatgtatac gatccatacc aaatggacag 3747541 acagccggca ttggaaagaa gaatcgcagc acttgaacgg caaaatgaac agcagtcaag 3747601 agaattaacc cgtctgacaa acgaagaccg ccgtcaaaat cgggaaattg cacggattgc 3747661 cgaacaggtc aatcagttaa gccaggctgt tgaacgccat acacgccgcc taaatcggct 3747721 caatcagcgc ctccgtacag tagaaaaccg gctgaatatc ccatttactg caggggaagg 3747781 cggtttctga gcgaaacaaa gaaaaaaagc ggaatacgat tctcccatct cagggtttcg 3747841 ttttccgcat ttcttatatg ttaaaacgga acatttacat aaaaagggtt tgtacccagt 3747901 atacaatctt taccgttttc attcaaagat agaggggctg aggaaaataa ttgtagttcc 3747961 tctttgacgg aatttctttt cattcaagtt gcatgataat accgactcac gtcaatcgat 3748021 acatggaggg atcattcatg cataatacac aacacggctt gcagcagctg aaccaatgcc 3748081 gccaaactgc tcagcagctc attcagcaaa cacagcaaag cagccagcaa tatcgccaaa 3748141 tgcttcatca ggaacagcaa aacatccaaa tgctgcagca gattctaaac cacgaacaac 3748201 aagctgcaca taccattcag caagcactgc acgggcatga catggcgatt caaaagtgcc 3748261 agcaggttgt caacatgtgc aaccaaatgc aacaggaact tactggacaa tccagcgtca 3748321 tgaatacgaa tgtgtctaca cttccattcg gccaaaacac gacatttcag cagcaatcct 3748381 accagcagta acatataaaa agctcaacac aatgcgagtg ttgagctttt tttcttactg 3748441 ttctttgcga atatgtatat cctgaataga ctgtttcggt gcatgaaatc tgctctcggc 3748501 ttcacttctt gcctcggcaa aagcccgcgc ctccacatga tctttgtaga catccagctg 3748561 aatcaaatac agcgggcgca ctttaaatcc atgaataatg gttaccgccc ataacgggac 3748621 cacaataaaa acaccgggca gatcgggcaa aacaaaacca aacgcaaaaa tgaaaaaata 3748681 aatgatgccg tacatgatcc actttctatt tctaaccttg atgccaataa ataaaaaggc 3748741 aaaaaaactg gtaatggcaa aaggcatgaa aataaacagc atccaccagc tatgcagcca 3748801 ttcccaagcg gcacctcttt ttgtaattcc catatttttc tcctcctatt tacctataat 3748861 aatcgattag gcacaccgcg tcacccataa acgggaaaaa ctttctccct taaaaatagt 3748921 gatagacgga gaacaggttt cttgctatat tattaattga taatgataat cattactaat 3748981 ctattgagat acatagtggg agggttcttg atgaaaaaga acatattgct cgtgggcatg 3749041 cttgtgctgc ttctcatgtt tgtcagcgct tgcagcggca cggcttctaa agggagctca 3749101 agcgattctg cttccgaaaa aacagaaatg agaacataca aatcaccaaa agggaacgtc 3749161 aacattcctg cacatccgaa acgcatcgtc actgattttt atgccggtga attgctgtct 3749221 gtcggggcca atgtggtcgg ctcaggctca tggtcatttg ataatccgtt tttaaaatca 3749281 aagctgaaaa atgtgaagga tgttggtgat ccaataagcg ttgaaaaagt gatggagctt 3749341 cagcctgact taattgttgt catgaatgaa gagaatgttg ataaattaaa gaaaatcgct 3749401 ccgactgttg tcatacctta taacacagcg aaaaacgtag aagacacagt cagcatgttc 3749461 ggagatatcg ccggagcgaa agaccaagca aaatccttta tggctgactt taacaaaaaa 3749521 gcggaagcag ctaagaagaa aattgccggc gtcatcgaca aagatgcaac cttcggcatt 3749581 tatgaaaaca cagacaaggg cgaattctgg gtgttcaatg acaatggcgg acgcggcggc 3749641 caagctgtat acaatgcact tgggttaaaa gcgcctgaaa aaattgagca agatgtcatc 3749701 aaaaaaggag agatgaaaca gctctctcaa gaggttattc ctgagtatgc cgcagattat 3749761 atgttcatta cggattacaa cccgaaaggc gaaagcaaaa cactcgacaa gctggagaat 3749821 tcctccattt ggaaaaatct tgacgctgtt aaacataatc gcgtgtttat caatgacttt 3749881 gactcgttct acccgtacga cccgatttct gtcagcaaac aggtggatat catcaccgac 3749941 atgctgatca aacgggccga agaaaataaa aaataaaaaa acggcacagt catgacgctg 3750001 tgccgttttt tatgattcac tttaattttg actgtacgga gtccggcata tcttcaaact 3750061 tgacttcttc ccaagtctcg acatactttc ctttcgcctt caccttcaaa tacgcgttct 3750121 tccgaagctc tttgccggcg aaaaaggtca cttcttcttt tttcccggat gcattatatc 3750181 cgtctaatgt atattcagta ccgcccggac taagatgtct gccatctcga tcaatctgaa 3750241 catagacatc ttgctggtga ataaacggat taaatctgtc tgtaacatcg ttatgaaaaa 3750301 agagaagccc gcatattacg gcagcagccg ccaagacggc caggattgcc attgcttttt 3750361 tcatctttgc actcccctta cttgttcatt tttttcaaat agcttgaccg caccgcgagg 3750421 aagaatagaa gctgaaaaat gaaaaaccct ccgatggtga gactgagcgg ccccgctaca 3750481 tcggaatatc cttccacagc caatgttctc aaggcaaaca gtgtatgcat gacggcaatg 3750541 acaaatggaa agaagaaaag aatcgccaat tgtattgtca cgctttgcgc catttctcgc 3750601 tcactcaggc cgattttggc cagtgaacgg tagcgctccc ggtcttcatc taaatcagtg 3750661 aacagcctga aatataagaa acttgctgcc gcgacaaaga atacaattgc gataaacagg 3750721 ccgataaata gactcaggct cggcagctgc accgtatcat agtaagtccc cgcttttgaa 3750781 gcaaaatcag aatgcacgtc gatataattg ccgtaaatct cattttgcaa ggattggctg 3750841 atctcaagac tgtctttcca atgatcatag ctgtagccgt ataatgacgc tttatcaccg 3750901 agtgatttca gctgatcaaa ggtttgatca ttcaccgcga tgatagcatt caatgagatc 3750961 agcggttttt tgacttcttt taccgacagt ttttgatcag acagctcccc tttttggttc 3751021 agcagcttca gctgatccgg cgcttcgttt ttgaaattgc ggtcatacgt tcccgggaaa 3751081 tagacagcct cgtcttcttt caggccgttc actttgacat ggaagtattt tgccgcatcc 3751141 gattcactga tcatgtaaac agggggaaca gtttctcctt cctgatagcg aacataggaa 3751201 acatctattt tgtctttcgt atacgtaaaa ccgtgtgttt tcagttcatg gtcaatatct 3751261 ttcaaatgag tctgttcttt tggattgttg ctgtaagata aatactccat ttcataagcg 3751321 gactcttccg ctccgacggt cgatttgtac attgcgagca cgcctgtcgc agtaaacgca 3751381 accgcggaaa taatgctgac aataaagaac aggcgggcgt tgtcttttag acgatagaca 3751441 aggtcagaaa cccaaatgat gtttttcccg cgcagataaa aggttttcca cttcttcagc 3751501 gcgcgcagaa tccatatgct gctttggctg aaaaagaaat atgttccgat aacggtgagc 3751561 agtaaaatga taaacggttc ggccccgtgg acattgcctt taagaaccat gccgtacccg 3751621 ccgcacagac aggcgatgcc gaataaggac agaagcacgg acggcttagg ctccggttta 3751681 accttgccag tgccctttat taatttgata accgtatttg atctgacaaa aaggatcgta 3751741 aactgcgata aaaagaaaaa taagagcaga aatccgcagg ccgtaatacc gagcgctttc 3751801 caaggcatat acaaaggcag cgcgtccatt tctaaaatat aagcgccgac cgtaaagaac 3751861 gtctttgaaa aaatgaatcc tccgataata ccggctgcaa ttgacatgac gccgatgatc 3751921 atattttccg cagtaatgag ctttctcagc tgccccggcg tgatgccctg catgagcaga 3751981 atgccgaatt ctttatttct cgatttcaaa aatgcattaa ccgaatacag aacaaataag 3752041 aaagaaaaaa caaagatcat ccattccgcg gcggttaagc cttttttggc gatgttattc 3752101 aggtagcctt cctttaatgc cggatgaaac aggaacatcg caaaggtaaa gaaaatcaaa 3752161 acggaaaagg cgctgcttaa aaagaatgca agataggccc ttttgtttct cgtgacgttt 3752221 ttataagcga actgaagaaa ggtcatttgc gtttcccccc agcatagaca gcacatcgag 3752281 aatttgttca taaaatactt ggcggttttc cccgcggtaa atctcattaa acagttcgcc 3752341 gtcttttata aagatgacgc ggcggcagta gcttgccgaa accggatcgt gggtcaccat 3752401 caaagccgtg acatgatcat cccgattcag gctctgcaac gtttccatga cgtcttttgt 3752461 cgctttggaa tcaaggtttc cagttggttc atcggccaga atgagtgacg gcttatgaat 3752521 gaccgctctt gcgatggcgg cccgctggcg ctggcctccg gatacttcaa acgtccgctt 3752581 gttaagcagg ttttcgatac cgagctttgc cgcgatgccg tgcagttttt cttccattac 3752641 agacggcgct tctttttcaa gcgttaacgg cagcatgata ttttcaccga tcgtcagcgt 3752701 atccagaagg ttgaaatcct gaaacacaaa tccgagctgc ttgcggcgga aatgagcgag 3752761 ctttgtccgc ttcaggcgat gcgggttttc tccgttaatc aggatatcgc ctgaatctgg 3752821 acggtcaatc gttgaaatga tattcaaaag cgttgttttt ccggacccgg acggccccat 3752881 caccgccgtg aactcgcctt cttctattga aaatgaaatt tgctttaagg cctgatagga 3752941 cacttgtcct ttataggttt tatttatatg tttgacttca agcatattcg ccatgaaaat 3753001 cctccttatg gttttattct tgttgatctg ggctgctttc atgtagtgcc gggacgttca 3753061 acataaaaat ccccttgaca taaatccatg ttatcaaggg gaaacaaagc gggctatgtt 3753121 gttttcttaa cgcagcctta catttttgta agaaatgaaa atcgaactga tgtcccttca 3753181 ccgggagacg agctgatgtc caccgtatga ttgagcttat ctgtaatttc tttgacgaga 3753241 tggaggccga ttcccgtaga ttcttggaaa cgccgcccgt tttcacccgt gtaataaggg 3753301 tcaaacaccc gcttgatgtc ttgtgaggga atcccgacac cgtaatcttt gacttcaagc 3753361 accgtcctgt cttcatcgca gaagacattc agctcaagtc tgtcactctt gcccgctgaa 3753421 tacttgaccg catttgtgac cacttggcca atcgcaaatt tgagccattt ggcatcggtg 3753481 taaatctgat gatcatcgca aacgttcatt ttcggataaa cgcgatattg aataaaaaat 3753541 cgtttatagc tttgaataac tgattggaga agctcggaca gggaaaccgc ttcgatttta 3753601 aaatcccgtt caaacaggtc gagccttgaa gaataaagaa gcgtctccag cccgaattca 3753661 atctgccgga cttctttttt gatttgttca aaaacgggct catcctcttc ttgaatgatt 3753721 aaattaatga ccgacagcgg cgtctttact tggtgcaccc attgattcat atacgtcacc 3753781 cgcgcgtcaa gcttggcttc ggtctcatgg agcttctggt gctgcagccg gatcagctcc 3753841 atctgctttt catacagctc tgaacagaac actgaagaac cgagatacgg gatatccgtc 3753901 ccttcctgcc ccgagctgag ccaatgatac acgccgcggt ctttgtacca gcgataggca 3753961 agatagcccg ccaaaataag aagctgcacg cccaatatgt aaaacaagtg agaaaaagaa 3754021 tgaagacccg caaaccagta ataaaagaag acaaacagcc cttgaaggag aaaaagcaga 3754081 atcagcactg catgagaccg gagaaacagc ttcatgactg cgccctcagc tggtagcctt 3754141 cgccccgcac cgcttcaata gaaacaggcg cattcagctc ccgcagtttt tttctgagcc 3754201 gcgtgatata cacgttaagt gtattatcat cgatgaatat gtcggtgtcc cacgtctttt 3754261 ccatgagacg gtcccgactc gtcacctttt ctccccgctc aagcagcact tccaaaagct 3754321 tgctttcttt tttagaaagc tcactttttt catcctgaaa acgcagttca aaccgttcca 3754381 caaagagctg aacgccggca tattcaacca ctttctctcc ctgctttgcg gcgtactccc 3754441 cgtacgccct ccggatctgg cttttgattt tcgcaagcac aatatcataa gaaaacggtt 3754501 tttcgatata atcgtctccc ccattttcaa tcgccatcac ctgatccatt tccccgcttc 3754561 tggcagaaat aaagatgatc gggcttgtgg agtgctggcg gatctgccgg caccaataat 3754621 atccgtcata tgccggcaaa ttgatatcaa gcagcaccac atcgggcttt tcccgcaaaa 3754681 agacatcaag aacagctgta aaatccgcgg cgaccactgt ttgatatccg tatttttcaa 3754741 ggtaattctg caatagtccg cgaatgtctt cactgtcttc cacaatcatg attttattca 3754801 aactgaacca ctcccgtttc ttacactgct gccatcatca taatcgtttt gggcgtatgg 3754861 acgcaacacc gcacaaaaaa accgccatct cggcggtttc tggtctcttt agccgacctg 3754921 ctgcttagct gctttaccgg ctgatccgaa ctctctcatt ttgcttcgca ctgtctcttc 3754981 cacggcttca atgccgggtg tcaaatagcc gcgcggttcg tacagatcgc tgttttcctg 3755041 aaacatgcgg cgtgtttcgt ctgtccacgc taccatacat tccgtattga tattgatctt 3755101 cgcgtggccg agcgtgatgg cttttttgat ctgatcctgc ggaatcccgg atgccccgtg 3755161 aagaacgagg ggaatatcag tcatgcggga gatagcctcc atttccttaa atccgagatt 3755221 cggctcaccc tgatatttgc cgtgtacaga gccgagggcg gcggccagcg cgtcgatatt 3755281 ggtttcttta acgatccgct cacattccgt gatatccgca tagcggaccc cgccgaccag 3755341 tccgtcttcc attccgccga ccgtgccgac ttcggcttct actgacacgc cgtgttttgc 3755401 ggcataatcg gtgacttctt ttgtcatcgc gatattctcg tcaatcggct gatgggagcc 3755461 gtcaatcatc actgagctga atccggcatc aatggcctgt ctgcagcgtt ccgcactgct 3755521 gccgtgatcg agatgaagca cgaccggaac ggtaatcgcc atgtcctcta ttaacgcgcc 3755581 gaccatggcg gcaatcgttt taaatccgcc taaatagtcg accaggcgat cggaagccgc 3755641 ggcgatgacc ggtgattgct ccttttgcgc cgcctgcaaa atcgccttcg tccattgcag 3755701 gccgttgata ttaaactggc caattgcata ttgctcccgc tttgcatctt caagaagctc 3755761 tttcatcgat acaaaagcca tattcacccc tcctttatcc attacatgct gaagtatttt 3755821 gatacgacat ccactgttgt ttttttcgct gtttgaatgg cttcctcagc agtcagctta 3755881 tagtattcag gccggaagag ctcaaccgaa acaacatcag agaagccgat ttccttcagt 3755941 gctgataagt gggcatctaa gtcaattgcc ccttgtcccg gccatacacg atcctcatct 3756001 gttaaaaagc cgattgggaa atcttctgta tcatcaatat gatagatgaa gattttcttt 3756061 ccgtccgcct gctttaagct ctcaatattt gaacccattg catggaagtg aaaactgtca 3756121 aggacaagcc cgacattgtc acggttaact gtgtttacaa tctcatacgc ctgttcaaac 3756181 gtattgaccg tacattgcgg atggccgaca aactcaagcg cgatttttac gccgtacggc 3756241 tccgcgatat ctgacagctc agtcagcacg tctacactgc tctttttgat ctcttctttt 3756301 acaatcttct gctctgtcac aagcggaacg gccaccacat atttcacacc gagggttttg 3756361 catgtttcca tcatgccttt aaattcagtg atgatctcgt tgtgaccctt ttcatcacgg 3756421 ttgttgaaga aaacgagtgc gtttaaggca agcggtttga tgtggtgggt ttgaaaatat 3756481 tccgcaaggt catccaatga atgatctttt aagtactccg gcagcttatc catagtacgg 3756541 atttcaatat aatcatagcc atgcttttcg catagttcta aatccagttt aaggtttgag 3756601 ttttccaatg ttgtcgcttc attaaaacaa agtttcatgc cagactcccc catctgcgtt 3756661 ttagatatga agggagttcg gcaggaaggc tgtcgccata tcccgccgaa ctccatgctc 3756721 agcttatgcc agacctaatt cttctttcat tttcttaagc ataaatcggc ttgattcatc 3756781 cgctctttca tcgacccaag caaatacggc attcgtcgca attccgtcga acttcatctc 3756841 tctcagtttt ctgaaaatcg tatcaaaatc aacctcgcct tggccaatgt ccaaatgctg 3756901 gtgaaccgtt actttcgcgt caggcggatt gacgatgtag cgaaggccat gagccgcttt 3756961 atgattatag gtatctgcaa ataaaacatg tgtgaggcgg tcgccggctt cgtcaaacat 3757021 ggtctcgatg tcgcctttgc cgtcatcata gaagaacgta tgcgcagtcg agtagacaag 3757081 attgatccaa tccttgtcaa gcgcgcggat catatccatc gcacctttgt gcgtttcgat 3757141 aaaatcatat ggatgggctt gaagattgag tttaatgcct tctttttcaa agactggcag 3757201 aagctcatcc atggatttga taaatttttc ttcacttgtt aaaggatcat attttgaacc 3757261 gctgaattcg ctgttcatca aatccacttc aagttcaacc gcaatttcga ttgcccgttt 3757321 ccagttgcgc actgctgcct ggcggcggtc ttcatcgggt cccgcccagt ggtaaagagg 3757381 aagaagcgat gaaagcttaa cacctgtatc tcttaaaagg cgctttaatt gtttgatctt 3757441 tgctgaatcg actttcggat atttataaaa cgggcaaaaa tcctcgcgcg gcgataattc 3757501 gatatattca tagccgagct ctgccgtttt atagaccatt tcctctaaag ttaaatcatc 3757561 acgatacatg gatggatcca atgctaactt catattttca ctcctctgtt ttttagtttt 3757621 gaactgttgt aaaagattga tagaattccg gtttttcctt caattcaacc ttttcttttt 3757681 gtccagattc ctgggctttt acacacgcgt cagtcgtgac agcagcaata tagccgtccc 3757741 atgccgtcgg tccgctgacc tcgcctttct tttgaatcga atcaataaag tcttggattt 3757801 ccacatcata cgcagcgaca aagcgtctct gccaatccat caaaatatca gtgctgaatc 3757861 tgccttcttt tctcaagctg atgcttgatg gctcgggaag cttgatgatg ccgtcttctc 3757921 cgacgatttc acattgaatg tcatagccgt atttacagtt cacatagatt tcagcattga 3757981 tgacgatacc gccttttgtt tcaatcacga cgatttgcgg atcttttaaa tgtggaagcg 3758041 cgttttttga ttttttcgga tagatgactt gaacggactc gtagtcatca ttgacgagcc 3758101 agtggagcac gtcaatttca tgaacaagcg tgtcgactac agccatatcc gttgtatagt 3758161 tatctcctac agtcgggttg cggtgcgcgc agtgaatcat aagaggctcg ccgatgacat 3758221 gattatcgag cgcttctttc agctgtacgt aaccgctgtc ataacggcgc atgaagccga 3758281 cttgaacaag gcgtttgccc actttgattt cttcttcgac aatgcgcatg catccttcag 3758341 ccgttgtcgc gagcggtttt tcacagaaca catatttctg ggctttaatc gctttcagca 3758401 cgcttgactc atgcgcaggc ccccagcttg tcactaaaac agcgtctaca ttttcgtctg 3758461 caagcaagct gtcatcattc ggataaaccg tcgcgtttaa ttggtattgc tcaacgacct 3758521 tttgtgcagc ttcttgatta acatccgtta cagctacaat ttccgcgcct gacagcttgt 3758581 tcgtgatacg gttaatatgt tcttttccga ttgctccagt tccaattacg ccaatacgta 3758641 aactcattga cagccactcc ttctgttggt tacatgattt tgctttctgt tcctttcttt 3758701 acttggctct gaggagaccc gtagagttcc tcttgaattt gttcaagcga cttgccagac 3758761 gtattcggcg caaagagcag cccgatgatc atactggccg tcacacatcc gagaagaatt 3758821 gcagccatcg ttccaatgcc gaaattggtg ataatcattg ggacaaacag actccaaatc 3758881 cctattgaaa tacggacaag gaaaaacatc agtccttgtg cggaagcacg atattgcgta 3758941 ggaaagattt cgctggccca taactgatag ttcgcttgct gcccggctcc gttattgatg 3759001 ccgatcacga caataaacag gagcagaatc ggcaggcctt caactggcag cagaaacagt 3759061 gtccacccga tcaccgccat gaaagcggcg attccaaata cggtttttct atatttgtcg 3759121 gcaaagggca tgaagatcaa ggcgaccccc aatcctgtga agataaacag ccccatttgc 3759181 aaaaggttgg ccatgttggc agatacaccg ccgacctgct gataaatgta tggcataaag 3759241 aagcccatga ccccggcggc taggttccaa accaagtaca cacccatcaa aaacaggatg 3759301 ctttttagat acataggctt gagcaaatca aaatacgatg tcttattcaa tacagccggc 3759361 ttctctgcct gagcttcctc cggctgattt tttgtctgcc aggcgtctga ttccggaagc 3759421 ctgattctca ggatgtacgt aatcagcgca atcacaagca gatgggcaaa tacgatttta 3759481 ttccccaaga gtcccaagtc accggccagt acggagagga gcagtacaac gacagcgccc 3759541 gcggcccaag cgacttgtgc tacgccgcaa tgcctggccc gattcttctt tggcgcattt 3759601 tccgcaataa tggtccatga cgcggttatg tcagccccta ctgataaacc gataatgatg 3759661 taaccgctta acaacatggg gaaattaacc ccgaacaaaa ccaaacaaat ccctagtgca 3759721 taaaccagca tactattggt ataaacagcc ttccgtccga ctttatcagc cagaaacccg 3759781 ccaagcagcg cgccgacagc ggcagaaatc gcatttgcgc tcaacgcgcc gagcagcccg 3759841 atttgcgtat cggatagctt aaggtaactg acccataatg ataaaccggc ggagcctgcc 3759901 acaattgaac cggcatcaat atagttggcc aatgctgccg cgattgtccg tttattgaag 3759961 gctgaatctc cattggtatt gcccatatgt tcattcccca ttaagccaga tccaacaact 3760021 gctgatcaat atagtttctc gcaatcaatg catactccag cgggtttgca acatcggggt 3760081 cttgttcagc ttcaatgaca atccatccgg aataactgtg cttcaacagc agctgatata 3760141 cttctctaaa gtcaatgcag ccgtcaccgg gaaccgtaaa catgcctttt aaaaatgatt 3760201 gccggaacga ttgtccttcg agcctgcatt gttccatgac attcaggcgg gcatccttaa 3760261 agtgcacatg cttaatgcgg ccgatatgct tctcaagcat ccccatgtaa tcgccgtcag 3760321 aaatatacgc atggcctgta tcatagagga ggtgtacatg cgcagggtct gttcctgcca 3760381 tcaggcggtc cacttcttcc gctgtttgga caccagtgcc gagatgatga tgatagacaa 3760441 gcttcaagcc atgctgagcg gcaatttcgc caaggtgatt cagcccttcg caaagccgct 3760501 cccattcatc atccgtaaag tgcggcttct ctgtgaacac atttttctcc aagctttgca 3760561 cgctgtacgt ttgttcagag acaactgcga catccgcgtt tacttgctgc aaatactcac 3760621 aatgcagggt aaatgtcttt gccgcttcac caagtccgtc acgcaaaata aaactgctga 3760681 accattttcc tgcaatgcgt aagttccgaa gcttcagctc tttgttcagg atggcaggtt 3760741 cggggaaaaa gcccccgacc tccgtgcctt gaaaacgtgc gacaacgata tcacttaaca 3760801 aatgctgaag tgtatttccc gctccaattt caggcatgtc atcattccgc cacccaatgg 3760861 gagcgattcc ccacaggatt tcatttttgc ccatctatgg tgcctcccct ctaatactgc 3760921 ttcgcagatt ccagcttttt ctcttttgct tcgtatgctt tctgaacgct ttcttgttca 3760981 gatacctctg ccaccccgac atgccaccag ctgtcatagc cgtccgtcat tgttttaggc 3761041 agcaccttca tttcaattaa tgttgataca tcctgtttct tcgcatcctc taacgcagct 3761101 tttaattctt ctactgtgtt tgcacggtag gttttcgcgc cgtatccctc agcgactttc 3761161 gcgtaatcga cattcaggat ttggttgtca tctgtgcgga actcgcaata gtagctgccg 3761221 ctgccgtgat ccatttgcag gttgttgatg catccgaatc ctgagttgtc aaagagcagc 3761281 acattgattt tcttgttgta ctgaatcgcc gtgatcagtt cagaatgaag catcaggaag 3761341 ctgccgtctc cgacgattga atacacttct ctgtcagggt gggccagttt aagaccgagt 3761401 gtcccggaca cttcatagcc catgcaagaa tatccatact ccaggtgata cgtattcgga 3761461 acattagaat gccacagacg ctgcaaatct cctgggagtg agcctgctga acagatgatg 3761521 acgctgtctt caggaatcgt ctcgttgatt gtcagcaatg ccgttgtttg cggaagctcc 3761581 gtattcaacg cgtcagcata ttcattcagg acctcttgag aaaagtgatt tttgatttcc 3761641 ggatcaaatg cttcccgctt aaacgtcact ttgctgagac gctcgcgttc agctagccat 3761701 tcgtccttca gctcccggat cgttgtgccg aactcgctct catagccttc aagcaagccg 3761761 tgcagtttgc caagcgtcac tttcgcatcc gccaccactt ggaatgcatc aagtttatac 3761821 gcctgcattc ggctgacgtt aatgttcaaa aacttcgctt tatcaaaatc aaaagcggtc 3761881 ttagaggatg tcgcaaaatc tgtatacctt gtgccgatgc cgataatcaa atcagcttgg 3761941 cgggccgctt tgtttgccgc aagtgtacct gtgatgccca ttccgccaag gttgttcgca 3762001 aaatctgcct caacggtaga ctttcctgcc tgcgtttcaa ctaacggaat gttataggct 3762061 tcagaaatgg caaccaattc atcgcgcgca ccggaatatt ttgcgcctcc gccgacgaga 3762121 atcacaggtt ttttgctgga tttaatcagc tccgccgcac cttgaagctc gcgctcgctc 3762181 ggctgcatgc gatcaatata gtgaacccgt ttgacgaaga aactttcatc aaaatcgtat 3762241 gcttcccctt caacatcctg agaaatacaa atcgttgccg gacctgcttt tgccggatca 3762301 gtcatgactt caaacgcgcg cagcaaactg ctcatcagct gctcagggcg cgtaatgcgg 3762361 tcccagtatc tcgatacagg cttcaatgca tcgtttgtcg taatcgccgc actgtattct 3762421 tgctccattt gctgcagtac agggtctggc tgtcttgtcg caaatgtgtc tgccggaatc 3762481 aagagaactg ggatattatt tgccaatgca gtgccggctg ccgccaccaa gttagccgct 3762541 ccaggtccga cggatgtaga caccgcatat atttttcttc tcagcatttg cttgctgtac 3762601 gccatggccg catgcgccat tccttgttca tttttccctt gatagacttt caaatggcct 3762661 gcatcctgct caagcgcctg cccgatccct aatacgtttc catgaccgaa aatcgtgaag 3762721 atcccttcga caaaaggctc ttcctttcca tctacatgga tgtactgctg gtttaagaat 3762781 ttaatcagcg cctgcgcagt tgttaagcga attttcttac ccacaaacga tcccaccttt 3762841 actcgatctt tttcaattat gactgtgctt caataagctg ttcgatttct tccgcagtcg 3762901 gcatcgcttc tgacgaactg tgcttgctca ccacaatgga ggctgaagca ctgccgtatt 3762961 tcaatgccgt ttcaatgtct tttccgctga caaggccata gataaaggct gacgcatagg 3763021 agtcaccggc cccaaaggtt ttcagcactt ttgtcttgta cgcttgagcg cggaatacct 3763081 cgccggattt gctgtatgcg taagagcctt cgacgccgtg tttgatgaca acgaggtcgg 3763141 ctgaatggcc aaataaatga ttgacggatt cttcattgct tccgcctgtg cggttttcca 3763201 tcacatcaaa ttcatcgcgt gtgccgatga cgatatcaga ctgctcggca accaaagaat 3763261 aataaacggc tgtttcatct gatgactgcc acgtatatgg ccggtaatcc agttcgaata 3763321 ccaccttaac ctgatgcttt ttcgcgtatt gaacagcttt taacaccgct tcccgtgacg 3763381 ggcttttggc gagcgctgtc ccggagacaa gcagcatttt cgcatttgcg atatagtcct 3763441 cacttacctc tgaaggctca agataaagat ccgccacatc atcgcgatac attaagatgc 3763501 tgcattcttc agggctgagg atttctgtaa atgcaaggcc tgctttgtgt ccatcttgat 3763561 caacaatcat ctgtgtagta tccacgccgg tctttctcat ataggactct atgaatcttc 3763621 catgctggtc atccggaatt ttgccgatga agcccgcttt taagccaagc ttcgcgctgc 3763681 cgatcgcgat attcgcaggt gaaccgccga catatttcga aaatgtcatc gtttcttcca 3763741 ttgggcggtt gtattcgact gcgttcagat caatacatgc ccggccgatg gcaacaatat 3763801 caaaagcctt ctcttcattg aatgtatact tcatcgtaaa cagccactcc tcacttgtta 3763861 gcgttctaaa atccattcat gcgccgggtc gttataaaac ttccattttc gcgtcggccc 3763921 tgccatgaca tttaaatagt aggatgtgta tccgtccgga acgcctaccg ggtggtatcc 3763981 cgcaggaacg atgacaacgt tttcatttcc cacagtcatt gtctcgtcaa tagaacggtc 3764041 atctgtgtat acgcgctgaa acacaaagcc ctgtcccggg tctaactcat ggtagtacgt 3764101 ttcttctaag aaagattctt ccggcaagtt gtcttggtca tgtttgtgag gcgggtagct 3764161 ggaccagttg ccgctgtctg tatagacttc aactactaat agactgttag ctgaagggtc 3764221 tgaatccgga agaatgttat gaacagtacg tttgtttgaa aattgcccgc gatgctcaat 3764281 tccgttgtct tccgctttga tcagctttgt cggaagctgc ttttccgatg gagaatagca 3764341 aagcgccact cttgcgtcgc tgaccgctgt gatctcaaat gcacggtcat ttgaaatata 3764401 gacgctgtct gtcggttttc gttcaaatac gctttcgcgc gtgccgatat tctcaaaagt 3764461 cgactcatga tctgtcactg taattttccc cgttaccgcc acaatacaga tttcttgttt 3764521 tttcaattct tctgtatagc ttgaacctga tgcaagatct aacactttaa actctacata 3764581 agtgagatca gagttggatg tcgttacttc gtgcacgagt ttgaccccat tagacacttc 3764641 atgcgactgc ggcttacgca acaaataact catagagaag ccctcctctt tctattggca 3764701 gaatgagtcc gaacagcgca catggacgcc gttcggctgt tcgtcgttta gttgaaatca 3764761 ggtgccggat atcttgccgt caccactttt ttacgtgtat agaagtcgac gctgtctttt 3764821 ccgttcgcat gcagcgttcc aaagaatgaa gatttccagc ctgagaatgg gaagaacgcc 3764881 attggagccg gcacaccaag gttgatgcct agcattcccg catcaatgtt ttcacggaag 3764941 tagcggattg cgtttgagtt ggatgtgaac aagcaggcgc cgttcgcaaa ctcagactta 3765001 ttggcgattt caatcgcttc tttcaggttt ttcacacgga tgacagataa gaccggagcg 3765061 aaaatttcat ctttccagat cgtcatttct gttgtgacat tgtcaaagat cgtcgggccg 3765121 acaaagtagc cgtcgtcaga cacattttca cgtccgtcac atacgagtct ggcaccttct 3765181 tcaagacctt tttcgatata gctgagcgtg cgcttcttgt tgtcttcgcg aatcaccggt 3765241 cctaagaaca cgccgtcatc aaggccgtta ccgattttaa tgtccgccac tttttcctgc 3765301 agcttcgcca taaattcatc ggcgattcct tcttcaactg tcacaaccgc acaagccatg 3765361 cagcgttcac cggcagaacc gaaggcagct ccaacgatgt ttgtaaccgt gtcttcaaga 3765421 ttcgcatcgt tcaagacaat cgtatggttt ttcgcgccag tcagagattg aacgcgtttt 3765481 aagttttcgc ttcctttttt gtagacgtat tcgcctactg gcttggagcc tacaaatgaa 3765541 atcgctttaa tttcgggatg ctcgaggatg ccgttcacaa cgtcatgcgc accgtatacg 3765601 acgttgaaca cccctttcgg aaggcccgct ttttcaaaaa gctcaaccaa tttctctgtt 3765661 aacagcggag tccgctcaga tggctttaaa ataaatgtgt tgccgagcgc gatcgccatc 3765721 gggaacatcc agcaaggaac catcatcggg aagttgaatg gcgcgattcc gccgacaact 3765781 ccgattgggt aacggtagtt cgccgcttca acgtccgttg cgatggaagc aagtgagtca 3765841 cccatcatca gggaaggtgc tccagcggcg aactctacgt tttcaatccc gcgtcccact 3765901 tcacctaaag cttctttcgt gttttttccg ttttcaatgg taattagatg agcaagttct 3765961 tctttatgct gagacagcag ctgctggaag ttaaatagaa ttctggcgcg gcgaggaacc 3766021 gccacctttg accatgtttt aaatgcttca gccgctgttt gcgctgcgta atcaatatcc 3766081 tcttttgtag aaatcggcac ttggcatagc acttctttcg tcgccggatt gacgacatct 3766141 tcatattgat ctgttttgct ttcaacccat tcaccgttga tgtagttttt taattttctg 3766201 atttctgcca ttcttattgc ctccttcatt agtaaacaca tacacttgta tggatggttc 3766261 cggatagatt catatcaata tccacttttc agcaagccaa gaattaaacg ctttcaaaaa 3766321 caccaaaaaa ataaatggcg gatgcatatt tacatacaag caaccatttc atgcacaaca 3766381 ggttactttt tggtcatttc ttggttatat tctaatcgca taatacccat aagtcaatca 3766441 taaacactac attttttcat tatttttatt atattaatct tttaatcaag taagagaagt 3766501 aagagaaggc cgtccaatct tgcaaaagat atacaccgat gttatcattt ttaagcaact 3766561 attgattaac ttttggtttt tattatatat ttatgttacg taaagattca agaaggagtt 3766621 ttttatatga aactgatgcg gattcaggaa atggaggagt acattttatc gcatggcact 3766681 gtttccttag atgagctgtg ccaggtgttc aatgtctcca aaaacacagt cagacgtgat 3766741 atcaacaagc taacagaaaa gggtgcgatt gaaaaagtat acggcggcgt aacatctatt 3766801 gaaaaaaccg cattagttcc ttttgaaaat cgcaccattc agcaccagga tgaaaaaaca 3766861 aaaatcgccc attatgcttc ccgatttatt gaagatcacg atttggtctt cattgattca 3766921 ggaacgacga caaagtctat tcttgatacg cttgatccag ccaaaaatgt caccatctta 3766981 accaacagtt tagacattat caatgcggcg tcagctttga agaatatcaa cttaatcatt 3767041 atcggaaaca actataagag aaaaacccgc tcctttgtcg gcatggacga cccggctatg 3767101 cttgataagt acaatatcaa caaagccttt atgtccgcta ccggaacgac gctgactcac 3767161 ggattgacca attcggatct gctggagtat gaaattaaaa agaggatttc agaaaaagca 3767221 aaagaagtgt atctattggc tgaccattct aaattcggaa aatcaacgct tctgacgtat 3767281 gcaccgtttg acaggctgca ttgcattgtg acctctcagc cattagacga cgagtacacg 3767341 cagtactgca atgagcatca aatcggcatt catctggcct aacgtttaca atagtgttga 3767401 gagtctatca tccattttat tctaggaggc agatcatgaa aaaagcgaag ctcggaaaat 3767461 cagacttgca ggtattccct atcggattag gaacaaatgc tgtcggagga cataacctct 3767521 acccgaacct aaatgaagaa accggaaaag aattggtgcg cgaggcgatc cgtaatggcg 3767581 tgacaatgtt agacaccgct tacatttacg ggatcggccg ttccgaagaa ttaattggtg 3767641 aagtgctgcg tgaattcaac cgtgaagatg ttgtcatcgc gacaaaagcc gctcacagaa 3767701 aacaaggcaa tgactttgtc tttgataatt caccagattt tcttaaaaaa tcagttgatg 3767761 aaagcctgaa gcgcttgaat accgattata ttgatttgtt ctacattcac ttccctgacg 3767821 aacatacgcc taaggatgaa gccgttaacg cgctgaatga gatgaagaaa gccggaaaaa 3767881 tccgttccat cggtgtatcc aacttctctt tagagcaatt gaaagaagca aacaaagacg 3767941 gtttggtaga tgtattgcaa ggcgaataca acctgttaaa ccgtgaagcg gaaaaaacat 3768001 tcttcccgta tacgaaggag cataatattt catttatccc ttacttccct ctcgtatcag 3768061 gtttattggc aggaaagtat acagaagata caacgttccc agaaggcgac ctgcgaaacg 3768121 aacaggaaca cttcaagggt gagcgtttca aagaaaatat cagaaaggtc aacaagcttg 3768181 cgccgattgc cgaaaaacac aacgtggata tccctcacat cgtattggcc tggtatttag 3768241 caagaccgga aattgatatt ttaatcccag gagcaaaacg tgccgatcag ctgattgata 3768301 acatcaaaac agctgacgtg acgctttctc aagaggatat ttcatttatt gataagctgt 3768361 tcgcataaga agaaaacagc cttctccaat ggagaaggct gtttttttgt gcgataaatt 3768421 cctaaataac tgattttgaa gcaaaacctt acaaaatgag ccataaatcc gataaaataa 3768481 aggtagttta tctcagaaag aaagtgattg agaaagcaaa agtatgaaac gttcatatca 3768541 tctagctcat atgaaataaa gctgacccag cttcttttat ttgctggtca gaatagcgga 3768601 ccgtttcgat ggtctatgga ggaaacagaa tgaaacttaa atatgtaaaa gccttagttg 3768661 cagtaaccgt tgctttaggt gtactgctgc catcaacgat ttctcatgca aagagcttta 3768721 gcggccgctc atcatctagt tacagcagcc gaagttcaag ctcatcatac agcggaagct 3768781 ataaatcaag cccgaaatca agctacagct caggatcaag ctcttctagc aaaaaatcca 3768841 agacgtctga cgattcatca tcatcgattt cgcttaaaaa gaagccttcg gaaaaggcaa 3768901 gttcatcaag ctctaaaaaa tcgtcaggca ccttttccgg cgctacatca aaagtaaccg 3768961 gaaagacata cagcggaaaa acgtctaaag cctatgttgg cggacgttat gtttcagtca 3769021 atcattacta tcacgcaggt ttcgcgccat caggatggtt tggatattat agcggattta 3769081 caatgggtat gttcatgatc agcatgatgc acccatgggg ttacacctat catccagtcg 3769141 gaggccccgg ttatgtttct tatggcgctt cacccattgc ctggatcgtt gatatcatcg 3769201 ctttgattat tattttaatc attgtcatcg cattgattcg cgcatttaaa gcaccgaaga 3769261 cgtacagaag gagattttag gcaatgagat taatattaaa tgagcaagaa attgtagacg 3769321 gaatttgcgt gtatatttcc aatgaagaag atatctaccc tgaagacgtt gaagtaaaag 3769381 aactatcgta caacaagcgt acagggttct tcgctgaagc tacatttggc ctgcaccaca 3769441 agcagcttat gtcagatgac atttcagaag gcattattca gttcttagag gaataccaca 3769501 acttcaatcc ggacgttacc gtcgttgaat tgcaatttga taagaaaaaa ggcttctccg 3769561 ccttggtttt tgtcaacgaa gcagaagaat aaaaatgtct taatcaaacc ttactccgcg 3769621 cgggtaaggt ttttttaatg gtttctctga gcataaagtt atttcgtttt tcctaaactc 3769681 agcggatctg tgatcatctc ttttggctat aaagtttccg ttttttcaaa acaaatgttt 3769741 caaatgagat aggaaatggg tactaatcta ttaactttgt tacatatttt tagatactca 3769801 ttggctcaac aactgaggag gagacatttg tgaagaaaga cacaaggaaa tatatgatct 3769861 actttttcgg cgctttaggg ggactgctat atggttacga tacaggtgtt atctccggag 3769921 cactcctgtt tatcaataac gatattcctt taacgacatt gacagaagga ttggttgtca 3769981 gcatgctgct ccttggcgcg attttcggtt ctgccttgag cggcacatgc tcagaccgct 3770041 ggggcaggag aaaggttgta tttgtccttt ccatcatttt tattatcggt gcgctcgctt 3770101 gcgcattttc tcaaacaatc ggcatgctga ttgcatctag ggtgatactc gggttggccg 3770161 tcggcggttc aacggcactt gtgcccgtgt atctttccga aatggcaccg acgaaaattc 3770221 gcgggacact cggcacaatg aacaacttaa tgattgtcac cgggattttg ctcgcctata 3770281 tcgttaacta cctgttcaca ccgtttgaag cgtggcgctg gatggtcggt ctggctgcag 3770341 tgcctgccgt gcttctatta atcggcatcg ccttcatgcc ggaatcgcca agatggctcg 3770401 tgaagcgcgg cagcgaagaa gaagcgagac gcatcatgaa catcactcat gaccccaaag 3770461 acatcgaaat ggaattggca gagatgaagc aaggggaagc ggagaaaaaa gaaacgacac 3770521 ttggcgtgct gaaagccaag tggattcgcc ctatgcttct gattggcgtc ggccttgcca 3770581 ttttccagca ggcagtcggc attaacacgg tcatctacta cgcgccaacc atttttacga 3770641 aggccggtct tggcacatca gcttcggcgc tcggcacaat gggaatcggc atcctcaacg 3770701 tcatcatgtg tatcactgcc atgatcttaa ttgaccgtgt cggccgcaaa aaacttctga 3770761 tctggggaag tgtcggcatc acactgagcc ttgctgcttt atcaggcgtg ctcctgacac 3770821 tggggctttc cgcatcaaca gcgtggatga cagtagtctt tctcggtgtc tatatcgtct 3770881 tttaccaggc gacatggggt ccggtagtgt gggtgctcat gcctgagctc ttcccgtcca 3770941 aagcacgcgg agccgcgaca gggttcacga ctttggtgtt atcggcggct aacctgatcg 3771001 tgtcgcttgt cttcccgctg atgctaagcg cgatgggcat cgcatgggtc tttatggttt 3771061 tctcagtcat ttgtcttctc tcatttttct tcgcgttcta catggtaccg gaaaccaaag 3771121 ggaaaagctt ggaggaaatt gaagcaagcc tgaaaaaacg gtttaaaaag aagaaaagca 3771181 cccaaaacca agtgctgaat gagcgtacat tataaaaaaa ggaatcgtct ccttatgaga 3771241 cgattccttt ttctgtttac accatgacct tgcaaatatt gttcgtaaat tccacagggt 3771301 cctgaatcgg caggccttcg atgaggagcg cctgattgta cagaaggttt gtgtacaggc 3771361 tcagcttctc tttatcttgt tcaaacgcgt cctgcagtgt ttggaatacc tcgtgatttg 3771421 ggttgatttc cagcactttt tccgccttca cattttggct gtcaggcatc gcatttaaga 3771481 ttttttccat ctcaattgtc acttcgccgt cagcagcaag gcagactgga tgtgatttaa 3771541 gccgttttga gattctgacg tttttcactt tgtctgacag aatgtttttc atttcctcaa 3771601 acagatcctt atacttgctt tcctcttcct cggactgctt ttgatcctca tccgtgtcta 3771661 tgccaaggtc tccgcttgat acggacttga attctttttc ctgataagaa gccagcattt 3771721 taattgcaaa ctcatcgatg tcctcagtaa agtagaggat ttcatagcct ttgtccgcca 3771781 ccatttccgt ttgcggcagt ttctcaatgc ggtcgtaaga atcaccggtc gcgtaataaa 3771841 tgaatttctg ctcctctggc attctggaaa catactcgtc taagctgacc agttttttct 3771901 cttttgaaga gtagaataag aggagatcct tcaattgatc cttattcgcg ccaaaatcat 3771961 tgtacacgcc gaatttcagc tgtctgccga acgacttgta gaacgtctcg tatttctcgc 3772021 ggtctttttt caacaggctt tgcagctcgc ttttgatttt cttgctgatg tttttcgcga 3772081 tcagcttcag ctggcggtca tgctgcagca tttctctgga aatattcagc gacagatcct 3772141 cagaatcgac catgcccttc acaaagctga agtggtccgg tagcaggtct gcgcacttat 3772201 tcatgatcag cacgccattg gaatacagct ccaagccttt ctcatattcc ttggaatagt 3772261 agtcaaacgg catgttttca gggacgaata gaatcgcgtt gtagcgaacc gctccatcca 3772321 cgctgatatg aacgtgtgtc agcggtttat caaacccgta atgcttttca gcatagaatt 3772381 tttcataatc ctcatctgtc agctcgcttt tgttttttct ccagatcggc accatgctgt 3772441 tgaccgtctg ctcttcctgc acctcttcaa attcattttc gctgccttcc ttcggcttat 3772501 taatggttgt atccattttg atcgggtagc gaatgaagtc ggagtacttc ttgatgatcg 3772561 cttttaaacg atattcctct aaaaactcgt catagctgtc atcttctgtg ttctctttga 3772621 ttttcaggat aatgtctgta ccgacagaat ccttttcaca cggctcaatc gtatagccgt 3772681 ctgcacccgc agactcccat ttataagcct cttcgctgcc aagcgcttta ctgatgactg 3772741 tcacgacatc ggcaaccata aatgccgcgt aaaaaccgac accgaactgc ccgataatgt 3772801 catgtccgtc tttcagctcg ttttcctttt taaacgcgag ggaaccgctt tttgcaattg 3772861 ttccaagatg ctgttcaagc tcatcctttg tcattccgat ccccgtatca gagatggtta 3772921 atgttctcgc atctttgtca gctgcgacct ttatgtagta actgtcttta tcaaacgtaa 3772981 gcgcatcgtc cgtaagcgct ttgtaataga ttttgtcaat cgcatcactc gaattggaga 3773041 ttaactcgcg caggaaaatt tctttttggg tataaatgga gttaatcatc atatccagca 3773101 agcgtttaga ctctgcttta aactcttttt tcgccactct tgatcgctcc tttaccatta 3773161 tgtaaaccct tttcagcatc tatttatcac ataagatgac aattgtcaat tagattgata 3773221 gatgcatata tatgtaaatt taacattagt tggatttgtt ttcactcttt ttctcactca 3773281 ttctcataaa aaagagaggc ttcatcatcc tctctttttt tctgtgtcat tccaacggcc 3773341 aaactcccgc ttcatccata tatgcaccgg gtagaaaaac aaaccgaacg gtatcaaaaa 3773401 caaaagatta tgccatgaag cattcagaaa tgcgcttgca gtcaccggga acgtaatctc 3773461 ttgcaataaa aaagagatga cagtcagcac aacaaatgca gatggaatgg tcacgatgca 3773521 ataaaacttg agctccttct tatgctgtac cttcaaacat acaaacctcc caacaatttc 3773581 taattcatct taacatatgc tggcctttct tttctcgcat gtttatcact gcacatagcg 3773641 ggaagacaaa tagaaaaagg aggtctcgta tcatgggaag acttgaaaac aaaacagcag 3773701 ttatcacagg cgccgcgaca ggcattggtc aagcgacggc ggaggttttt gccaatgaag 3773761 gcgcgcgtgt gatcatcgga gatatcaata aagatcaaat ggaagaaaca gttgacgcaa 3773821 tcagaaaaaa cggaggacag gccgaatcct ttcacctcga tgtgtcagat gaaaacagtg 3773881 tgaaagcatt tgctgatcaa atcaaggatg catgcggaac gattgatatt ctgtttaata 3773941 atgccggcgt tgatcaggaa ggcggaaagg tgcacgaata tccggttgac ctgtttgacc 3774001 gcattatcgc cgtcgacctg cgcggcacat tcctttgcag caaatatttg attccgctca 3774061 tgctcgaaaa tggaggctcc atcatcaaca cctcctccat gtcaggccgt gccgcggacc 3774121 ttgaccgctc cggctacaac gccgcaaaag gcggtatcac caacctgaca aaggcaatgg 3774181 caatcgacta cgcacgaaac ggcatccgcg tcaattccat ttcaccgggc acgatcgaaa 3774241 caccgctgat tgacaaatta gcaggcacaa aagaacagga aatgggcgaa caattccgcg 3774301 aagccaacaa atggatcacg ccgctcggac gtcttggcca gcccaaagaa atggcaacag 3774361 tggcactgtt cctcgcatca gacgacagct catacgtcac aggagaagac atcaccgcag 3774421 acggcggcat catggcgtac acatggcctg ggaagatgct gattgaggag aaatggaagg 3774481 aagaaacgaa ataagagagg gagccccctc tctttttgtc ttttaaagca atacaacctt 3774541 atatttcttc acatccaaaa actgcaaaaa ctccctcgcc agcacttcag gcggatgcgc 3774601 ctttccttca tccagccgat acaaaagcaa cccgataatc attgcggata cataatgggc 3774661 ataaagcttt ttctctgcgt gaatatcagt ttgctgatgc agataaaacg attccagcgc 3774721 tttgaacata tcaggtatca catgaggaac accccattcc cgattgagaa aatggacaat 3774781 gggcatgttt gacaaagcag aaagcagaat ggcgagcgcc ttctccgctt cctttaagga 3774841 aaattcattc gggctggagg caatcgtcag gtgatcaatg atctccgcac atgatcgctg 3774901 tatcatggtt tggagcaatt cctccttatt ggcatagtga tcataaaagg ttgcacggcg 3774961 gatattgctt ttacgcgtaa tatctgaaat cgtgatgccc gcgtagtctt gtttctccgc 3775021 caatacatcc agaaatgcct tctgcagcgc ctctctcgtt cgaaccaccc gcctgtcgat 3775081 ttgcttctcc ttctctcgct ctcctggcac agcttttcca aacagccaat aaaaccgctt 3775141 ttgagaaaca agctcccata ccttctggct gatggcttca ggagacgcgg ccgcatcctc 3775201 attcagccaa tacaggataa tcgcgtacgt gtacaaggcc cgataatgtc cataaatgtc 3775261 ccgttcaatc ggcgttaaat tcacatggat cggagccagc agcacatcct gctgaaacac 3775321 atccttaaaa aaacgatgaa aatgtcctct gttcatcatc acagaaaaaa aggaacgatg 3775381 ctcatgaaca aaggacagcg tcggatgcac cgtttgccgt tttttgttca aatgaagggt 3775441 atccatatga ctgaaggcgt caaaaagcgc tttgcccagt ccttccttca tgtcttcgat 3775501 cacatcctca atgattgaaa acttatcctc ataataaagg tagagcgatc cgcggctcac 3775561 tttggccttc tcagcgattt ctttcattgt gatgtgttga atatctctat ctttcaataa 3775621 agccagcagc gcctctttca cttgagcttc ggcagattcc ggcacaaaag acacctccaa 3775681 tcattagaca gatcttagat atatgtacgg taacgtatag atggttcacc gttgtctttc 3775741 ttacagaaaa ggtaccacct tataataggt ccgagaaaag aagaaagcaa atgaggggga 3775801 ttttacaatg gaacagcaag taaaggacga catccagcgt gtctttcagc ttcagaaaaa 3775861 acagcaaaaa gccttgcgcg cttcaacagc ggaacagcgg agagaaaagc ttcaacgctt 3775921 tttagattcc gtcatcgccc atgaagaaga aatcatcgaa gcgatccgca aagacgtccg 3775981 caaaccatat cacgaagtca aaaaagcgga aatcgaagga acaaaaaaag cgattagaga 3776041 taatatgaat aacctggaac aatggatggc gcctaaagaa gtcggttcat cgttaagccc 3776101 tgacgcaaac ggaattctta tgtacgagcc taaaggcgtc acactcatcc tcggcccgtg 3776161 gaactatccg tttatgctga cgatggcgcc gcttgccgct tctctcgcag ccggaaacag 3776221 cgcgattgtg aagctgtccg atttcacgat gaacacgagc aacattgctg ctaaagtaat 3776281 aagagacgct tttgatgaaa aagaagtcgc gatttttgaa ggagaggttg aggtggcaac 3776341 cgaactactt gatcagccgt tcgaccatat tttcttcact ggaagcacaa atgtcgggaa 3776401 aattgtcatg acagcggctg ccaaacactt ggcatctgtc acacttgagc ttggcggcaa 3776461 gagcccgacg atcattgaca gtgaatacga tctgatggac gcagcgaaaa agatcgccgt 3776521 cgggaaattc gtaaacgccg gccaaacctg catcgcacct gattacctgt tcattaaaaa 3776581 agacgttcag gacaggttcg cggggatttt acaaacagtc gtcaacgctg gatttatgga 3776641 ggatgatcat accccagacc gcagcaaatt tacgcagatc gtcaatgacc gcaacttcaa 3776701 ccgcgtcaaa gatctgttcg acgatgccat cgaaagaggg gcggaagtgg tgttcggcgg 3776761 cgtattcgat gccagcgacc gcacgatctc gccaaccgtt ttgaaaaacg tcacgcctga 3776821 catgaaaatc atgcaggagg aaatcttcgc atcgatcctg ccaatgatga actatgaaga 3776881 catcgacgag gtcatcgatt acgtaaatga ccgcgataaa ccgcttgcac tttatgtgtt 3776941 cagcaaaaac caagatctga ttgacaacgt ccttcagcac acgacatcag gaaatgccgc 3777001 catcaatgat gtcgtcgtcc atttcagtga cgtcaacctg ccattcggcg gcgtcaacac 3777061 aagcggaatc ggctcctatc atggggtata cggattcaaa gagttttctc atgagaaggg 3777121 tgtatttatt caggccgctg aataatcgca tgatcaaaag gcgcttcctt agaggagcgc 3777181 cttttattgt aactccttga ccaaaagcaa ttcatcacgg ataggtattt tattatctgc 3777241 cagtaaagga atttcgggct tcatctttct ggccgtctcg actgcattca caaatagtcg 3777301 atccaaccgg taccctctct tctgataaaa cgctaatgca tgaatattat cattggttgt 3777361 gatcagtttt atttgtttga tatttctctc tctgcatgct tcctcggctt tctctagcag 3777421 agctgttccg atccctttat tctcaatgac actatccagc gaaatgattt cacaggcatc 3777481 ttcttcaaat atgtatgtaa taaggccaac aatctggtta tcatcgttga gcattccata 3777541 accatctaat tcatcgcagt tataaatacc gctagaaata accatttgcg gactgcccca 3777601 gtgtttttga aaaaacgcgg aaacaagatc tttaggtacc tggcatgtcg gaataatatt 3777661 catattttcc tccttttagc tgaacaaaaa taagagaatt aacaacctat tttatgtcat 3777721 taatcccctt atctagtatt tactagaact tataacttgt caaaagctgt ctgaatacca 3777781 attgcgtgga ttgataagga tcaaaatctg aatcctgaga ttggaagatt tgctctgggg 3777841 tcaatgtctc tgcgttctct gataacgttt gaatcagact ttccaaatat ccatttaact 3777901 ctgatttgga cgattcatgt agggattgat gatttacagc gagttctcta aatctgttat 3777961 cactgattaa tttttttcga agagctgcta gcatcaagtc aagccatgca ggctggccaa 3778021 atgtaatatt taaagctaac gttgcttgat cagatttggt ggagtgccat aaacctcttg 3778081 gcaaatacag catggttccc ggtgttaaat taacgatttc tgcatctggc agatcctctt 3778141 ttggcggatc tcctttccaa tatgactgta aatcatcagg atagtaagga gcctctgata 3778201 aatcatagtg ctgcattgga ttgctcacat tttcattctt ggcaagcttc catgttttct 3778261 caccttgaat ttgaaaaatc aagttggtgt aggcgtcaaa atgggctttg aatcccccgc 3778321 catttttcgc cgcgtaaaca atggctttgg aagaagtacc cgcaggcagt cttaattccg 3778381 ctttgagttt ttctatccac cttctgactt ggggaataaa taggtcggtg aaatcaaact 3778441 ctaatgcagc ccctttttca taccactcta aagcctctgc aggtgacaca agaaatctgt 3778501 ctgtgatccc ttcagattct tcaatcacag catcaccaac gaccatgact ggattattgt 3778561 agatagccaa tacgttttct agcgttctaa ccttttcaaa ccccggtatg cttgtaaatc 3778621 tctccacttc tcctctggct accaaaggtt ttacaggcca atattcttct aaaaactcac 3778681 tcatcgttac aggactgatg atagactcca aaaccgattc ggttacagca ctcatattat 3778741 ccctcccaaa aaaagtaact tcaccacaaa gatataacat ttttttctaa aagtaaatat 3778801 tgacagaatt atcagaggat tataatattt agttgtgcgt gatagcctat ttttttacaa 3778861 ggaaggaggg aaaaggatga aaaaggctta taagaaacct cgtctttttg aactgcgccg 3778921 tgctgtagca gctggcggcc attaatctca tatagcattt gacatctagt actctatttt 3778981 aggagggatg ctcaatgaaa aaagcttata agaaacctcg cctttttgaa ctgcgccgtg 3779041 ctgtagcagc tggcggccat taatctcata tagcatttga catctagtac tctattttag 3779101 gagggatgct caatgaaaaa agcttataag aaacctcgcc tttttgaatt gcgccgcgct 3779161 gtagcagctg gcggtcatta atcttatcca aaacgattaa cgtttgaggc tatcacgcca 3779221 acttgataag gaggatgctg aagatgatta cggctgaaga atgcagaacg tacaaagaat 3779281 ttgttgatct ttaccaatcc tatctttacc ccttgcttgg cgccagactg tcccggatgt 3779341 attcccccaa aaacaaagtc attatcgata tgggcacagg tccaggttat ttaagcattc 3779401 agttggctaa aagaacaaat gcgcacgtgc atgctgtcga tattaacccg gccatgcatg 3779461 aaatcgctca agaagaagct aaaaaaagcg gagtaagcag cctgatttca tttgatttgg 3779521 aagatgtcca ccatttatct tacgctgacc aatatgctga cttcatcgtc tcctactctt 3779581 gcctgcatca ttgggaagac gttgttaaag gacttaaaga gtgctataga gttctggctc 3779641 cgggcggaaa aattgtcatt ttggatacat ttaatcccca aggaagccat ttagagatta 3779701 tgcgaaaaca aatcaaagaa ccggaatact tcaggtttgt aagagaggca tttgaagaaa 3779761 gttattcctt tgaagacatt caccagtttg ttcaggatgc cggcattccc aattattcat 3779821 tagaaacctt tcacttttta ccggaggatt ttatagaaag cttagatgag ctggaggatg 3779881 ctcccctgtg ggaacaaaat gatcaaagta ctgatcatga aattgagtct gtcacatgga 3779941 tgttaacgat agaaaaagaa aaggaaggtg cattgtaatg atcaatgaat caactgtttt 3780001 atccaaaaat ccagaaatgc catcaagaaa atatttgaaa agcattatta tagagccggg 3780061 catcacttta aatgaaatgg catcagatat ttataaccat atcgacggca aggtcagcat 3780121 acatgatatt tgctcaaaaa tcgtcaatga atatgatgtt gattatcaaa cctgcttaga 3780181 agattgtatg gagctgtttg agttgcttat tgatcatgaa gcaatcaaag ttaagcaggg 3780241 ggcatgagaa ttggaaaaac aaaaagtgct tgctttacca gacgatgtac atgagctgag 3780301 tacacaccgt tctaaatcaa tcgtaaatta catcatcact ctgcttgcct ttgccaaaaa 3780361 acaaggattg actcatcaag atattgtaag ctggattcac gagcaatatg aggaaagagg 3780421 atattatgat gagtggagac acattaacag ccaacaacca gttggatcat ttgtggaact 3780481 ctttataaaa ggaagacgtt tactttatga caaaattgaa ttgtttgaaa cagaagataa 3780541 atatgtcgta aatacccaca cttggtatga aaaagaacct agtgaggcct ttttttattt 3780601 tgaaattgat cccgaagaat tttctgcgta cgcttccatt ctcgcaatcg aaaacgcaaa 3780661 acgtctcgga attaaaatcg atattgtaaa agaaacagat gtagagacag cttatatcta 3780721 taaacatcaa taacgctatt gggagggaga catatgtgcg ggctcgcggg tattataaat 3780781 ctggctgctc cccgttctca ggaatgtacc tttcatatat tgaaaggcat ggcagatgcc 3780841 atcagctata ggggaccgga tgatgaacaa tatcatattg attccaaagt cggctttgca 3780901 tttcggcgat tgtccattct tgaccttgta aatggacagc agcccttttt aaatgaggat 3780961 ggatcaatcg tcgttatggt aaatggagaa atttataact ataaagaact gaaggcttct 3781021 ttacacaatc atatgtttaa aacgacatct gattgtgaag taattgttca tttatatgaa 3781081 gaaaaaggga ttggatttgt agacgacatc atcggaatgt tttcaatagc catttgggac 3781141 aaaaataaaa acaaagtatt tttagttcgt gaccgctttg ggattaaacc gcttttttac 3781201 acagagctaa aacacgagct tatatttgcc tctgaaataa aatccctatt ttctcatcct 3781261 cactgtcccc gccaatttaa ttggaaagaa gcactctcag acatttggct aagcggggaa 3781321 gcagccagta atcataaaga aaccacttcc ttttttgtaa acatccaaaa tctcgatgct 3781381 ggccattatc tcgaaattaa tttgacaaca aatgaacgaa aaacagcaag ctattggtct 3781441 ttacaggata ttttgctcag gcaaggctat cgtgagaatc tccatcccga tgacctgatt 3781501 gaaggatata gagaactgct ggcagattca gtccatagat gtttacaaag cgacgttgaa 3781561 gtcgggttgt ttcttagcgg tggcattgat tcagctgcag tcgcacattt tgctgcagaa 3781621 aaacaggatc tccatacgtt tacagtatta agccaaagta catttacaaa tgaagatgca 3781681 aaatatgccc attggctggc taaagattta caccttccaa atcatcaggt tctctatcaa 3781741 ttagggaacg atgagttatt acaaccagag tcatataaac atttgttatg gatctgtgaa 3781801 acaccgtttt gcggaccgga acaattatat aagtttcatt tacataagta tgccaaagcg 3781861 ataaggccaa acctgaaagt catgctgacc ggccagggca gcgacgaatt taacggcggt 3781921 tacagcacga cactttcacc agccgagaac ccaagttggg aaggatttat tgaatcggtc 3781981 aatacgatgg agatgaaccg gctgcatcgg ctgcagggaa atatctttag agtgtgggag 3782041 gagcattttg gactttctcc tataaacctt tcttatttaa agagcaatga ttccagccaa 3782101 gcagatcctt ggcaatcgta tgtcctgaca aaataccgtg atctgcaaat gtataattgc 3782161 tggcatgaag atcggatcgc cgcggctaat catatcgaaa accgtgtacc gttcttggac 3782221 catcggcttg ttgaatgggt ttgcggaata cctgatggac tccgtaaaga cttgttatgg 3782281 gataagtcgg tattgcgaaa atcattaaca aatgagctgc atacaagcta tacccaccgg 3782341 ccaaaggttc cttttttcta tggtaaggac gtgagatata cacataaaat gatgtttcat 3782401 cttctgaaga aaaacaatta tcagcttata gaggaggcct tctctcacag cgatgcctcc 3782461 agcataatac aggttgaaca cattcatgcc atcatgacat atttggagga tgatcctgag 3782521 tttacaaatt ttgaattttt attaagactg gtgaacatgg gacttttatc aaaaatgact 3782581 aaagaaaccc cttctgttca attagacata accagccatt tagaatcgat aacaataaaa 3782641 gactggcact cacaggaagg tgatattgcc agtcgtttaa atatctcagc caataagtgt 3782701 gaaggacaag atattttggc gctaaaccct ggcgtcactc tgttaaggcc ggaaagcgat 3782761 agtgagcatt gcatctacat tgcggaagaa ggatttattc agtttattgt ttcggaggaa 3782821 gacgtcggag cttggctgca tattctctgc gatattaatg gaaaagacac acttcatacg 3782881 attttagaca gacatggtgt cagccttgaa gaagtggcca aatatattca agaagccatc 3782941 gaacacaata tcattttgat caaacaaaaa aatctgccag aaggagcata tagatgagca 3783001 tcttttattc gttttccgca cttaggggat tagcaatggg gattttttcg cctatttgga 3783061 ttctttatct gatatctaaa gattatgatt tccttcagat tggattaatg ggagcggtac 3783121 ttgaaattgc taagcttata tttgaagttc cttccggcgt ttttgctgat cgttatggaa 3783181 ttaaaatttc aattgccagt tcattctttt tctccatcct tacatgggcc ttcttccctt 3783241 ttatcgattc agctgctatt tgcatactgg ctatgatcat atgggcttta tcagattcct 3783301 taatttccgg ttcttttgaa acttggatga gccgtgtcgc aggggaagat cgattcggca 3783361 aagaaatgat gaaaaacaca caattgctaa tcactttttt aattattgga agtattgcca 3783421 gcgggtattt gtattcatta aatatctatt ttcctttcct gctcgttatg gtgatctact 3783481 tattactatt tatttggatg tctgtattta ttaaagtccc ttctgtttcc gaaacaaatc 3783541 atggggatca gaaccaacat gattcgataa agattatcaa agaaagttta aaaattatct 3783601 ttaacaaaaa aagggttctt ttaatcgtca tagccggttt ctttacagcc acagcctatg 3783661 acacaatttc ccgttactgg cagccttttt tgagtgattt aggcttttca gaaaagtcac 3783721 tgggatatat ttttgcccta ggagggttta ccgctctcgt tcttttgaca ttaaccatca 3783781 ggttcgaaaa gaagatcgaa aaaaatccat atctcgcttt aacctcattg gattccatgg 3783841 gcatggtcat gacttttcta ttgtctagag cattcaggcc gctgggcatt ccatgtacag 3783901 cgtttttgct tgcaattgaa gatattcatc atccgatcgt aacaagttac ttaaataagt 3783961 ttttccccga ttcatacaag aacacacttt tctcgttaaa ctcaggggta ggagcaattg 3784021 gagaaattct ttccggtgtc attttcggca tcatttccgc agcctttggg ctctctgcca 3784081 tgtttgttgt tgtagctgta tttctattaa tccctattat cctttatacg atagtgccta 3784141 agattaaaga caatgatatg aaagttcaga ttgaaaaatc ccagcaagtg taaatgtttt 3784201 gtatcacagt aagaagacct tcttattaaa agaaggtctt ctgctattct attcagttat 3784261 ttcccaaaag ccatcagctt cgtataactt ccaatataaa gtgttccgtc ctcagcgagc 3784321 tgaggagaag acacgacgtt gctgtcggtt tgatagctcc ataattcatt gccgtttgcg 3784381 tctgccgcat aaaccttcat atcatctgac ccgaaataaa ccgttccctt cgcgtcaatc 3784441 agcggcgccg ttctgacagg gccgtctgtg tagaatgacc agttcatatc cccgtttttg 3784501 ctgatggaaa acagctcgcc gcttcctgag ccgatgtaga tattgccatt atgatcaatc 3784561 gcaggagatg agctggagaa cccgtttagc gggaatgtcc atttcaaact gcctgttgat 3784621 gtataagcat acagctgtcc atcttggttg ccggcataaa tgtttccgtc cttatcaatc 3784681 accggatatc ctttaaacgc atttgacgtc gttctggacc atttcacctg tccggttccg 3784741 gagttgatcg cataaaacac gtaattatat gtgccgacat acacggtgcc gtttttggca 3784801 agcaccggca cagagctgac gaccccattt gttttcaact tccagcgctc tgtccaggtt 3784861 gattttgacg tcggtttgat cgcgtgaaca taattatcaa gtgttgagaa atacaacgtc 3784921 ccgtctgaac cgatcaccgt ttcagagctt ggcccgccgc ttaacggaac cgttgttaaa 3784981 atttctcccg tttctttgtc aataaaataa atctttttgt cataggatgc caaatagata 3785041 acgccgttgg tcccaagtac aggagattgc gtatatgttt ttccaagatt gcccgtcacc 3785101 catttgactg agccgtctgg attaaaggct ttcatttccc cgtctctgga atgaagatat 3785161 actgtgccgt ctccgtcaat cacagccccc gctccatttt gcggagtcgt tctgatgtcg 3785221 ttttgccatt tcagcgtccc gtctgtattt ccggcgaacc ggctttcgcg tgaccagtta 3785281 aacatggcag gcgccatcgc ttgtacatca tatcttcctg gcaaaaagcc agatgctcca 3785341 ttattttgag aaaacaccgt ttccgccgca taagcagctg tcggctgaag cactttggca 3785401 gcgggcacat cagaaacagc gccggccgaa acagccgccg ccaccgcagc tcccgcaatc 3785461 aaagctttca tacgaaatga cttgaccatc attgagaccc ccattatatg taacttctaa 3785521 tttgtgacca tcataacata ttcatccatt ttataaatct atttcacaaa aacatcacaa 3785581 actagaaaac tatgtaagag tattcacgga cgttttttca gcacccgatc gaaatgcagc 3785641 cacaaaccaa atgacgttga cagcagccgc agcgagacta actcccaaaa caaagatcac 3785701 ctcagaaagc agatggtcac taaagaaact aaacatcaag ataaaaccgg ccgaagacaa 3785761 atgaatcaaa agcccgaagc cgcaaagcac cgccatgaca tacctcattg catcgactcc 3785821 gagcatataa acgagaaatg gaatgaaata caagacaagg atcataccga cagctgacca 3785881 catgccagct gaattaaact gattggccgc cgctcccgtt ccggccagcg gcgaaagtga 3785941 agccgccaca atcacggcgc aaaaaagaaa cgcagaaatg gttgtcatga tcgccacgct 3786001 attttttttt gacatcaaac tcctccttta atagaaatat taaccttttt tattataagt 3786061 aagttgaatg ttatattcat tatattttta aaaaattcca gaatacatac acaaatgcta 3786121 tgcttctttc tagtatattt atatagtaaa aaacaaagga taaaagactc atttttctgt 3786181 aatatcagga ttttatcacc ataccatatt gcatgtacat gtttttcaaa gtatactatt 3786241 ccagattaat tcagaggaga gagaaaaata catggaaaaa ccagcaggat tttggattcg 3786301 ttttttagct tattttattg acggcattat tgtatctgtt cctagttata ttattctatt 3786361 tattatcaat tctgtgtttg tagctggggc tgtggcaaca aacccttaca tgacggaaga 3786421 agagtattta gtgaaataca tgacgcttgc atttttgcct actatgctga tcatgatcgt 3786481 catcagcgtg ttatattacg ggctgctcac agcttctaaa atgcaaggca cacttggcaa 3786541 aaaaattctt ggcctgaaag tggtcaatga acaaggtgaa cgggtttctg tcggacaggg 3786601 aattggccgt tactttgcct atatcttatc tggaatcatc ttttatatcg ggtttatcat 3786661 gatcgccttt ggagagaaaa aaggcctgca tgacatcatt tgcaaaacac gtgtcgtgta 3786721 taaataatag aaaaaagtct agacgccaat aggcatctag acttttgttt tctttgcaat 3786781 aggctgccac gacagatacg tagcgcttct ccacaaccac tcaaacggcc ccatccgaaa 3786841 gacacgaagc caaaggtggc tgaagaccat ttgaacggca caaacagcaa ttgtaatgag 3786901 cacaccggca gcagggtaca cttttccata caggcccaag ccgtaatgat aaaaaatcca 3786961 agtacacaca atagactgca tcaaataatt ggtaaatgcc atcctcccaa cagcggagaa 3787021 tgattgcagc actgttctca ctcttgtttt atgataaaga tagacaaccg ttgtaacata 3787081 gaaaaacatg aggaaaggcg cgccaatcag caaacatatt tctttatccg ttacactgta 3787141 cagcacctgg gcgccgatgc cgatgacaag cccagccatc cataatcgtt ttaatccttt 3787201 gcgatgcttt tccggttcat gcaaataccg tgattttgct gccgcagctc ccagcaaaaa 3787261 catgctgaaa tatggaatgg atgcaaagaa gtagttgagc ggattatacg taagcatgcc 3787321 attcgaagac atgtaaacaa gacggtcgtg gatccgctgt tctgcaatat ccttcaggct 3787381 gccgcttcca taaacatgaa tcgcttgttt tgcctgctgt gttaccgctt gtacccattc 3787441 ctgtccgttt gattgatcaa aacttgtcaa catgaacgga atggaaaaca gaagatacaa 3787501 agagaccgcc catatcagca gtgttttcgg ctttgctttt cgaaacaaga gcaggacaaa 3787561 tccgagcagg gcatattctg ttaaaatatc cccgtcccat atcaaaaagg catgaatcgt 3787621 tccaaacaag agaagcgcca ttaaccttct cacatataac ggaacaaacc gtttcccttt 3787681 gttttctgct ctctccatca tgacaaccat gccaaatcca aataaaaagg aaaacaataa 3787741 aatacatttt gtttgaatga agaatttcag tatgtctgcg gcggcaaaat cagcttcaga 3787801 ccacttatcc atgaaaaaat tctcttttcc aagcatagac aaatacatat ccggataact 3787861 gaaatgtgcc agattgacaa ataagatgcc gaaaatcgcc attcctctca gcacatcaag 3787921 cacaccgatc cgctcatttg ttaaagtcgg ctgtaatgaa gacatagcca tcacgctcct 3787981 tttttctgta ccttaagggt aggaaaaaat gaagcgcggt aacatcgatt taggtgtcag 3788041 gccggcatga aaaccttaca atcttgtcat ctttatggtt tcatcacctt taaatctaat 3788101 gcttcgatat tctgcaaaat gcgatcaaag cgcaaagcct gaggctcaca tgggaagatg 3788161 tggccttcat acgggtcgcc taacgtccgg aaaaacggtt caaataaacc aggaaccaat 3788221 acgcccacca tctttgtata gtgagaatca aggcgatagg agtgaacggt atttgcaggg 3788281 acatgcagga aatctcccgg attcagctga atttcctggc catctgtcca catcgtcatc 3788341 tggccttcaa ggcaataaaa tgtttctgta tgatattcat ggtagtgatc aacgattcgg 3788401 tcacctttag ggccttcaga tgatacgacg ataaactggc catctgtatt tttttgtgca 3788461 gccacaatgc ggtgaagctg atctccagtc aacagacgat ctccttctcc agattcaaga 3788521 acgtatggaa ccgctccatc tggcagctct gtaagttccg ctaatttggc cgaacatgca 3788581 ggctttgctt catctagaaa tacaatgtcc gctacagcgg ctgcttctgc aaatcgctcg 3788641 tttgagactt cttcgcttgc gtacggcgga tgttcagcgt gatcatacgg attcccaata 3788701 acggaataca agtgcgctac gtttcctttc atcgtgtaag acaccagtct tgttctgtgg 3788761 ctctgcatcc ggtagctgtg cggtgttccc gccggaatgt tggcataatc acctgatatt 3788821 aataaatagc gttcaccatc aagtgtcagt tccagtttcc cgtccaaaac gagaattcct 3788881 tcatgtgtgt ccttgtggac gtgaagcgga aaggcatctc cttttccccc ggaaagaagc 3788941 acgatctcaa acaaatcacc tgtgctcctc ccattcgcca tcaccgtggc aacctgtctg 3789001 ccgaacagat agcgctcgcc ttctccgctc cggagcaaat aaggcatttt ttctttaggc 3789061 aatgaatgtg tacataatgt tttcatatta tcgcttcctc caatttagac cagtctatat 3789121 attatcattc atttgtctag accgttctat ataattgtag gagaaaggat aacaaaatgc 3789181 tacccttttt ttctcaccag cactggtatt tgttcggcaa tgagaagaag aggcgttttg 3789241 tctttattcg ttaacgaaag catgatgccg ccctcaatca tcgaattaat cagcgttcca 3789301 agctgatttg cttcttcttc tgcaaatccg ttttccatta attttctggc aaaaaccgct 3789361 tcccagcttt taaacacctt catgcaaacc gtccgcagcg gttcactgat taacgctgtc 3789421 tcactcgcca gcaaaccgac tggaatacct ttaatgcttt ctgtgttgtc aaattggctg 3789481 gctgtttttt tgataaaaag ctgaatcgct tcaacaggat cagaggattc atccatgctt 3789541 tgctgtatca gatgttcaac gatcttacct gtatatgtaa ccgcttcaat tgctagttct 3789601 tctttgccat tcggaaaaaa gtgataaagc gatccttttg gagcaccgct ttcttttaca 3789661 atctggttca aacctgtcgc gtgatatcct tgcagctgga acagacgtga cgccgtgtga 3789721 aggatttttt cacgtgaatc tcctctgcta gtcattaaaa cattccctcc taggtatggt 3789781 agagcgactt atataatata aaaaagaacc ctgtgattgt caaaaggggt aagacccttc 3789841 cggatggggt aatgtacaaa aacagcgtct aggagggatc tctcaatgac aatcgatcat 3789901 tcagtcacaa atacagagca gcttgaacaa cagaaccccg ccataaaaac aaagctcaaa 3789961 ctgaaaaagc ttaaggatca ggtgatcgtc attaccggcg cttcaagcgg tatcggactt 3790021 gtcacggcga gaatggcagc tgaaaaaggc gcaaaggtcg tggcagcagc gcgaaatgaa 3790081 gaggcgctga aggagctcac tgatgaactt aaggaaaaag ggcacgacgc catatgggta 3790141 aaggcggatg tcggaaaaga agaggacgtc aaccgcatcg cagaaaccgc gatcagcaca 3790201 ttcggccgct ttgatacatg ggtcaacaat gcggccgtct cgactttcgg acacgccatg 3790261 gacgtcaccg tcgaagacat gaagcgcatg ttcgacacaa atttctgggg acctgtttac 3790321 ggaacaagag cggctgtcaa acactacacc ggcagaggtg tgccgggcgc actcattaat 3790381 gtaggaagcc tgttcggaga caggggaacg gtcattcaat ccacatatgc atctgccaaa 3790441 tttgcgcttc acggctggac ggaaagcatc cgaatggagc ttgaaaagga acaggcgccc 3790501 gtctcggtaa cgctcatcca cccgggcaga attgacacac catataacga gcatgcgcac 3790561 agctacctcg acaaacagcc ggctcattac cgctccatga tctatccgcc ggaagcggtc 3790621 gccgaagcga tcctgtttgc cgccgaacac cctaagcgcg acatgtacat cggctcacag 3790681 gccaaagcca tcgccatgct gggcgcgctt tttcctcgtc tgaccgacag actgatggaa 3790741 aaaatcatgt atcacagcca gcatgccgaa agaccgtcca atccgagaga agaaagcgct 3790801 ctttatgatg ctggctgcgg tatgcatgac agaggcacaa ataaaggatg gatgaggtca 3790861 agaagctact acacaaaagc gacgaagcgc ccaattgtat cggcggctgt tgttgccgga 3790921 ctagtggctt gggctgccgc caaacgatgc agataatctc tgaccataag aaaaacccat 3790981 gctgttccag cgaaccatgg gtttttcagc tgttaatcga taaaagcctt gttcatacgc 3791041 tgcagcagct cgccgaacat ctctttttcc tgtgttgacc attctttcag catctgttca 3791101 taacgttcaa ggcgcttttg ctgatcggct tttaatagtt gtttgccgag ttttgtaatg 3791161 gtaaacaggc tgactctccc atcagacggg tctgagaaac gatagatgag ctcctttgcc 3791221 tctaatgcag ctgcttgtct tgaaagagta gaaatatcaa gcttaaacga ttcagccaat 3791281 tccttaacac gagcaggccc aaactcatcc aattgtctca gtaataagta cgaagatctc 3791341 tccaaattcc ctgttctttt ctccgattga tccagataaa cagctctcct gataaaagtc 3791401 gtcagctcat attcaattaa ttcaactgga ttttgatttt gcaatcgctc tcgctcccta 3791461 ttccaatctc cggcattgac aacatcatat atacttgtat aatacaaatg tacattaact 3791521 gaataaatac aagtcgttat atgactaaat caattattat acttgtatag tacaatcata 3791581 taaaaagaaa gtaaagcgat tcctcagaac catcctagaa gcaagcacca gaaaggagga 3791641 agctgttctg attggagagc agcacttgat gtgaaagtca tacgaattat tttgcaagtg 3791701 ttgatattat atgtattttt tatgatcggg gaagccattc agcatctgtt tcatttaccc 3791761 gtgtcaggaa gcatcgttgg attggtattg cttctgatct gcttgggcct ccgtattgtt 3791821 cccgtctcca tcattgaaga cggagcaggg tttttattat ccttccttcc attgttgttc 3791881 atcccggcaa tgacaggagt gataaactat ccgtctctca tttcattcaa tggcctgatg 3791941 ctgctgatta cagtcgttct cagcaccatc gtcacgatca ttgcggctgg attcgccagc 3792001 cagctattag agaaaaaagc aaaaaaacgg gaggagaaag agaaatgcag caagcatgta 3792061 tcgcgatcat tataattctt ttaacagttg ccgcttattt agcgatggtc aaactctata 3792121 agcgattccc gcttccattt ctgatccctg ttctgacaac gacaattttg attgtagcgg 3792181 ctttgatgat gtttcatgtt tcctatgaag gctatatgat cggggggaaa tggatcaatt 3792241 ctttgcttgg gccggctgtt gtggcgctgg cctatccgct ttataagcaa tggcatatca 3792301 ttgtcaaaca ttgtgttccc attttaggcg gcgtcctggt cggcttatgc atgggaatga 3792361 tcagcgggct gatcttcgca gaagcattcg ggattgatca tgatctctta ttatccattc 3792421 tgccaaaatc gatcacaacc cctgtcgcta ttcagatcgc cgccggtctt ggcggcgtcc 3792481 cttccatgac agtcgtattt gtcatgattg cgggcttttc aggcgtcatc ctcgggccgc 3792541 ttttcctaaa atggcttcgc atacgcagct ccctaggaca aggcattgca ttaggcagcg 3792601 cctcccatgc actgggtacc tccaaagcgt tggaatatgg ggaattggcc gtatccatga 3792661 gttccgtctc catgacgctt tgtgcggtgc tcggctcatt cttcggcccg ctcgtcgtct 3792721 ggctgtttca tatttaacaa agaaagactg ccccggggga gggcagtctt tttcgtttaa 3792781 gaagcaaaaa aatcaatcaa cggctgaaag tccttagata aatcaacgtc attcggttct 3792841 gcttgaagca ggcggtcaat catacgctcc agctcctcaa catcattctt atccgtatat 3792901 tcaatgaagt ttaagctttc aagccaatcc cgatatgaat gtttggcttt gccatagctg 3792961 tttccaaaga caaggcaagg tgttttggtg ataatcgaga aaatcatcgc gtgaaggcgg 3793021 tcggtaatca ccaatttact ggagccgatg cggtccagca tctccataaa atgcttttca 3793081 cgatcagcgt aatcgatggt gtctaccgta tccagcaccg tatcggtacg ctctgtgtaa 3793141 gttgtttttt ctgcccattg cttcatctgt gaaataaaat cttcgtcagt cactttctcc 3793201 ttatccgctc ttaaaataaa gagaacgccg tcccgctcga gctctcgcgg cacaatatcc 3793261 aaggaaagca ccatgtccgg tgtaaagatc acattggagt tgaaggtctc tttcacaaca 3793321 tccagtgttt gcgtctcacg cgcagcaatc gttaagtttg tattttgatg gtacgcatcc 3793381 tgtgtttttt tcttttcctt ctgtccttcc tctgtatcct caaaataaac ggattgtggc 3793441 agagaaattg atttgtagtc tttaaacgcc gaaaagacct ttcttctgtc ttcctcaata 3793501 tcgagataaa ggtttcctaa attccctccg cctgtaaagc agacaatatc gtcttcacga 3793561 atgatctcct tcaccagttc aatgccctca tccgtcgcat aatccataat ctcaatgtat 3793621 tcataatacg gaaaatgatt tttgataaat ttctcttccg catacgcaat cgcttggtcg 3793681 ccaatgtttg tgtagctagg ggaaccaaac aaaaatactt ttcgtttatc atttaacaga 3793741 gcttccggct ccacatttgg cgcaatgcct tttactagtt ttttgccttt gatttcttgt 3793801 acagtcatat ctgcgtcctc cttctgggat gaattcctca ttgtgtgtta actgtctcta 3793861 cccaaaaaga aggatggcta tgcattggca tgtgcatcgg ctatatcaga aacatcgttt 3793921 tcgccaattt gatagacgct gcaatgtccc gcgccgttct ttccatatat tccgcggcat 3793981 gttcaaacgc gtcttctagt ggcacggctc cggggacgat gctgaaaagc gcatcgattc 3794041 cgtgttgata gacggcatta ctgtctcggg aaattgatcc cgcaatgccg ataacgggca 3794101 catcgtatga tttagcggcc ttggccaccc cgatcggtgt ttttccatga accgtttggc 3794161 tgtcgattcg tccctcgccg gtaatcacaa ggtctgcatc ctgaacgata ctttcaaaat 3794221 caaccgcttc aaggacaata tcaatgcctc ttttcaggtc agcctgaaga taagttagca 3794281 ggctccatcc aagaccgccc gctgcaccgg cgccctctgt atctcggaag gttgatccga 3794341 gcgctttttc tgccatatca gcgaaatggc ttacgttctg gtctagtaca tccaacatgt 3794401 cggccgtcgc gcctttttgc ggcccgaaaa cagccgtagc accctttggt cctgttaacg 3794461 gattgtccac gtcacaggca acttccagtt tgacattccg caatctggaa tcaagcccgc 3794521 tcacatctat tgatgcaagc tgagataacg cgccgccccc tgggccaatc tcgctgcctg 3794581 agttatcaag aagccttccg cccaatgcct gaatcatccc ggctcccccg tcgttcgtgg 3794641 cgcttccgcc gattccgatg atcaatcgct ccgctcccgc atcaagagct gctccgatta 3794701 attctcccgt tccccttgtt gtagtgatga gcggatttcg cttatctaca ggcaccagat 3794761 gcagccctga agcagcagcc atttcaatca cagctgttct cccatctccc atcatgccaa 3794821 agaaagctct caccggttcc cccagcggcc ctgtgacaac ttgctctatg atccttccat 3794881 tggtcgcatc gaccagagat tgaacggttc cctcgccgcc atccgccacc ggcaattttc 3794941 tgtaatcagc acccggaaag accgatttga aacctctttc tatcgcttcg gctgcctcca 3795001 gagctgataa gctttcctta aaagaatcag gtgcaatgat gattttcatc caaatcgcct 3795061 ctttcaaaac atgattcact taacctattg atctccaatg taccataatt gatctggaaa 3795121 tacataccat gcaatatggt aaaaatttaa ataaaaatta gaaatgaaag tgtttgcata 3795181 aaagaaatat tcacgttatc atacttgtat acaagtatac tccttgagtg aggaaggtga 3795241 gtgtatgcta gactccaaag acctgttgta tcccgcaaaa tggctctcaa aagcgtcaac 3795301 cggagttcgt gtcgcatacg agctgagaat gcggatcgtt tcaggtctga ttgaaagcgg 3795361 taccatttta tcagaaaata caatcgccgc cgagttttca gtaagccgtt cgccggttcg 3795421 cgaagcgcta aaaatactcg catccgaaaa aatcatccgc ttagaacgaa tgggagcggt 3795481 cgtaattggt ttaactgaga agaaaatcgc ggaaatttat gatgtgcggt tactattaga 3795541 aacatttgtc tttgaacggc ttgtcaaaat agacattgag cctttagtta aggatctcag 3795601 caaaattctt gaaatgatga aagtctcaat caaatatgag gatgctgacg aattttcatt 3795661 tcaagatgtg ctgttccatg aaacgattat ccgagcgatt gatcattcat acattcagat 3795721 gatctggaac aatctaaaac ccgtcatgga aagctttatt cttttatcga tgcgggtacg 3795781 gttaaaggaa aagtatgaag acttcacaag gattttagat aaccacgagc tttatattca 3795841 agccatcaaa acaaaggata gggcgctgat gattcagtct cttcaccaaa actttgatga 3795901 tgtgcaggat aaggtagaag acctatggct ctcacaacaa atgctggcaa aaggagctga 3795961 atacaacaat gactagttat atgttaggaa tcgatatcgg cacgacaagc acaaaagctg 3796021 tgctgttcag tgaaaacgga gatgtggtac agaaagaaag catcggctac ccgctctata 3796081 caccggacat ctcaacagct gaacaaaatc cggaagagat ttttcaggca gtcatccata 3796141 caacagcgag aattacaaaa cagcatcccg aaaaacggat ctctttcatt tcgttcagca 3796201 gcgccatgca cagcgtcatt gcaatcgacg aaaatgacaa gccgctgacg ccatgcatta 3796261 catgggccga caacagaagt gaaggctggg cgcataagat caaagaggaa ttgaacggac 3796321 atgaggtgta caaacggacg ggaacaccga ttcatccgat ggcaccgtta agtaaaattg 3796381 cctggatcac gaatgaaaga aaagaaatcg cttccaaggc aaaaaaatat atcggcatca 3796441 aagaatacat ttttaaacag ctgttcaatg agtatgtcat cgattactca ttggcatcag 3796501 cgacaggcat gatgaacctg aagggcttgg attgggacga agaggcactg cgcatcgcag 3796561 gcatcacgcc ggatcactta tccaaactcg tgccgacaac cgagatcttt cagcactgca 3796621 gcccggaaat agcgatccaa atgggaatcg atccggaaac gccttttgtc atcggcgcca 3796681 gcgacggcgt gctgtccaac ctcggcgtca acgccattaa aaagggtgaa atcgccgtca 3796741 ccatcggtac aagcggtgcc attcggacga ttattgacaa gccgcaaacc gatgaaaaag 3796801 ggagaatttt ttgctatgcc ttgacggaca agcattgggt tattggggga cctgtgaaca 3796861 atgggggcat cgtccttcgc tggatcagag acgagtttgc ctcctccgaa atcgaaacag 3796921 cgacacggct gggcattgat ccatatgacg tgctgacgaa aattgcccaa cgcgtcagac 3796981 ccggttctga cggtctgctg ttccacccat atctcgccgg agaacgcgct ccgttgtgga 3797041 atccggatgt acgcggctca tttttcggct tgaccatgtc gcataagaaa gagcatatga 3797101 tacgcgcggc attggaaggc gtcatttaca acctgtacac ggtgttcttg gcgttaactg 3797161 aatgcatgga tggcccggta acccgcatcc aagcgacagg gggttttgca aggtcggagg 3797221 tttggcgcca aatgatgtcg gatatcttcg aatcagaggt tgtcgttccg gaaagctacg 3797281 aaagctcatg tctcggcgcc tgcattttag gcctgtatgc aacaggaaaa atcgattctt 3797341 tcgacgccgt gtccgatatg atcggcagca catacagaca tacgccgatc gaagactcag 3797401 ccaaggaata cagaacatta atgccgattt tcatcaatct atcaagatta ttagaaaatc 3797461 aatatacaca aattgcagat tatcagaggg gcttaatcac acacaaatag tacatgacat 3797521 gaaggggagg gcattaccat gccgttaatc atcgttgcac ttgggatctt agcattacta 3797581 tttctgatta tgggcttaaa attaaacaca tttatttccc tgctggtcgt atcgttcggc 3797641 gtggcactgg cactcgggat gccgttcgat aaagttgtca gctccatcga agcaggaata 3797701 ggggggactc ttggccacat cgcgctcatc ttcggactcg gtgcgatgct gggcaaactg 3797761 atcgcggatt caggaggcgc acagcgcatt gcgatgacgc tcgtcaacaa attcggtgag 3797821 aaaaatattc aatgggccgt tgtcattgcc tcattcatta ttgggattgc gttatttttt 3797881 gaagtaggac tggttctatt aattccgatt gtctttgcga tttcaagaga attgaagatt 3797941 tctattttat ttctcggaat cccgatggtc gcggcactat ccgtcacaca cggtttcctg 3798001 ccgccgcacc cgggacctac ggcgatcgcc ggtgagtatg gcgcaaacat tggagaagtg 3798061 ctgctgtacg gctttatcgt tgctgttccg acagtgctca ttgcagggcc gttatttaca 3798121 aagttcgcga aaaaaatcgt tcctgcatca tttgcgaaaa acggcaatat tgcatcactc 3798181 ggcacacaaa aaacatttaa ccttgaagaa acacccggct ttggaatcag tgtctttact 3798241 gcaatgctcc cgattatcat catgtcggtc gcgaccatta tcgacctgct tcaagaaaca 3798301 atcgggtttg cagataacgg agttttagct tttatcagat tgattggaaa cgcatcgact 3798361 gctatgatta tttcgttatt ggtcgcagtc tatacaatgg gcatcaagcg caacattcca 3798421 gtcaaaaccg tgatggattc ttgttcaact gccatttcac aaatcggcat gatgcttttg 3798481 atcatcggag gaggcggcgc cttcaaacaa gtgctgatca acggcggtgt cggcgattac 3798541 gtagcagact tattcaaagg aacggcatta tcgccaatca ttctggcatg gctcatcgca 3798601 gcgatcctgc gcatttctct aggatcggcg actgttgccg cactaagcac aacaggtctg 3798661 gtcattccgt tattgggcca ttctgatgtt aacctggcgt tagtcgtact cgcaacagga 3798721 gccggaagtg tcatcgcttc acacgtcaat gacgccggct tctggatgtt caaggaatac 3798781 ttcggattaa gcatgaaaga aacattcgcc acatggacat tgctggaaac cattatttcc 3798841 gttgctggac tgggattcat tttattgtta agtttagttg tatgaaatta agaaggagct 3798901 gtaacacatg ttcaattcga ttggtgtcat aggcttaggc gtaatgggaa gcaacatcgc 3798961 cttaaacatg gcaaataaag gcgaaaacgt cgctgtctat aattacacca gagatttaac 3799021 ggaccagctt atccaaaagc tggatggaca atctctcagc ccgtattacg agcttgagga 3799081 ctttgttcaa tcgttagaaa aaccaagaaa aatctttttg atggtcacag cgggaaaacc 3799141 cgtagattcc gtcatccaat cattaaagcc tttgcttgaa gaaggcgacg tcatcatgga 3799201 cggaggaaac tcccactatg aagacacaga aagaagatat gacgagctga aggaaaaagg 3799261 gatcggctac ctgggagtcg gcatttccgg cggtgaagtc ggtgcgttaa cagggccttc 3799321 catcatgccg ggcggagatc gcgacgtcta tgagaaagcc gctcctatcc tgacgaaaat 3799381 cgcagcccaa gtcggagatg acccttgctg tgtctatatc ggaccaaaag gggcagggca 3799441 ctttacaaaa atggtgcaca acggcattga atatgccgac atgcagctga ttgcagaagc 3799501 ttatacgttt ctaagagaaa cgcttcgtct gccgctagat gaaattgcat ctatttttga 3799561 aacatggaat caaggtgagc tgaaaagcta tttaatagag attacagctg agattttacg 3799621 caaaaaagac gaaaaaacag gacagcctct gatcgatgtc atccttgata aaaccggcca 3799681 aaaaggcacc ggaaaatgga cgagcatgca ggcgattgat aacggcatcc cgtccacgat 3799741 catcacagag tccttgttcg cccgctactt gtcatcttta aaagaagaac ggatggcagc 3799801 tcaagatgta ttagcaggcc cggaagccga agaaaaacac ttggataaag acacttggat 3799861 tgaatacgtc agacaggctc tttacatggg gaaagtatgc gcctatgcac aaggctttgc 3799921 ccaatataag atgtcatctg agctttacgg ctggaatctg ccgctcaaag acatcgcctt 3799981 gattttccga ggcggctgca tcatccgcgc tgatttccta aacgtgatca gcgaagcatt 3800041 cagtgagcag ccaaatctgg ctaacctgct gatcgcgcct tatttcacag ataagctcca 3800101 tgcctatcaa acaggcctgc gaaaagtcgt ttgcgagggt atcagcaccg gaatctcttt 3800161 cccatgctta actaccgcgc tctcttatta cgacggctac cgcacagggc gttccaatgc 3800221 gaacctcttg caggcacagc gcgattactt tggcgctcac acgtacgaac ggactgatat 3800281 ggacggcgtc ttccatacga attggtctga ataacctgta ttaaaaacac ggtcagtttc 3800341 aactgaaccg tgtttttttc ttctatccca aacaacagaa gacataagtt atgttttaaa 3800401 tatcataaac agtgatacaa taatagctag aaacaatccc caagatcatc atgtgacagc 3800461 agattgctgt tccgttctat tctgcttttg gccattgtcc tttgcccttg accatggtgt 3800521 cataaaatgt tcaaatgcca aaacggcctg gcattctgat ttacaaaagt ccctgaaaac 3800581 cttatctaat tgagaatcag cctctcattt attataaaag aaatgcctaa atcctacctg 3800641 tcacaccttt attaagatga aaaaaagtag gttatggctt gacaaaaaat atatattaat 3800701 taataattca tatataatta gaattattat tgaaagcgat tatgctttct aatacatttt 3800761 taggaggaat atacattatg tctttaatcg gtaaagaagt acttccattc gaagcaaaag 3800821 cattcaaaaa cggtgaattc atcgatgtaa caaacgaaga tttgaaaggc caatggagcg 3800881 tattctgctt ctacccagca gatttctctt tcgtatgccc aactgagctt gaagatcttc 3800941 aagaacaata tgctgcactt aaagaattag gtgttgaagt atactctgtt tctacagata 3801001 ctcacttcgt acacaaaggc tggcatgaca gctctgaaaa aatcagcaaa atcacttacg 3801061 caatgatcgg tgacccatct caaacgatct ctcgcaactt cgatgttctt gacgaagaaa 3801121 ctggccttgc tgaccgcgga acattcatca tcgatccaga cggcgttatc caaactgttg 3801181 aaatcaatgc aggcggtatc ggccgtgacg caagcaacct tgtaaacaaa gtaaaagcag 3801241 ctcaatacgt tcgtcaaaac ccaggtgaag tttgcccggc taaatgggaa gaaggcggcg 3801301 aaactcttac acctagcctt gatctagtag gtaaaatcta aggagtgcat tcaattggta 3801361 cttgatgcaa atatcaaagc acaattaaat caatatatgc agctaattga gaatgacatt 3801421 gttctcaaag ttagcgcagg cgaagatgac acttctaagg acatgctggc tctcgttgat 3801481 gagctggctt ccatgtcatc gaaaatttca gttgaaaaag ctgaattaaa cagaacgccg 3801541 agcttcagtg tcaatcgtgt cggagaagac actggcgtga ctttcgccgg tatccctctg 3801601 ggccacgaat tcacatcatt agtgttggcg ttgctccaag tgagcggcag accgcctaag 3801661 gtagaccaaa aagtcattga tcaggtgaag aagatcagtg gtgaatacca cttcgaatct 3801721 tatatcagcc tgacatgcca caactgtcct gatgttgtac aagctttaaa catgatgagc 3801781 gtgctgaacc cgaacattac gcacacgatg attgacggtg cagcatacaa agcagaagtt 3801841 gaaagcaaaa acatcatggc agtgccgacc gtttacctga atggcgaatc cttcggaagc 3801901 ggccgtatga cgcttgaaga aattcttgcg aaaatgggca gcggcacaga tgcatctgag 3801961 tttgctgaca aagagccgtt tgacgttctt gtggtcggag gcggacctgc tggtgcaagt 3802021 gcagcgatct acactgcacg taaaggcatc cgaactggtg ttgtcgctga gcgcttcggc 3802081 ggacaggttc tcgacaccat gagcatcgaa aacttcatca gcgtcaaagc gacggaagga 3802141 ccgaagctag cggcaagtct tgaagagcat gtgaaggaat atgatattga tgtcatgaac 3802201 cttcagcgtg cgaaacgcct tgagaagaaa gatctgttcg aacttgaact cgaaaacggc 3802261 gctgtcctga aaagtaaaac agtgatcctt tcaacaggtg cacgctggcg caatgtcaac 3802321 gtccccggtg aacaagagtt caaaaacaaa ggtgtcgcat actgcccgca ctgtgatggg 3802381 ccattgtttg aaggcaaaga cgttgcggta atcggcggcg gaaactctgg tatcgaagca 3802441 gcgattgatc ttgcaggtat tgtcaatcac gttactgtac tagaattcgc gccggaactg 3802501 aaagcagacg aagtcctgca aaaacgtctc tacagcctgc ctaacgttac tgtcgtgaaa 3802561 aacgcacaaa caaaagaaat cacaggtgat cagagtgtta acggcatcac atatgtagac 3802621 cgcgaaacag gcgaagaaaa acacgttgaa cttcaaggtg tattcgtcca aatcggtctc 3802681 gtgccaaaca cagaatggtt agaaggaacg gttgaacgca accgcatggg cgaaattatt 3802741 gtcgacaaac acggcgcaac aagcgtacca ggcttatttg ctgccggcga ctgcacagac 3802801 agtgcgtaca accaaattat tatttctatg ggatcaggtg caactgccgc cctcggcgcg 3802861 tttgattacc taatccgtaa ctaatataag aaatccgcta tattgccaga ttggcaggat 3802921 agcggatttt tctttttcta cagaaaaaaa ccgaaccagg cactacggta aaagtgctcg 3802981 attcgagcgc ttcttatagt tcctcaccat tcgtttgaat gacattttta taccactcaa 3803041 aggagtcttt cttatatcgt ttcatggatc cgtttccttc attgtcacga tcaacataga 3803101 tcatgccgta gcgttttttc atttcgccag ttgtgaagga gacaatatca ataatgcccc 3803161 acggcgtgta gccaattaaa tcaacaccat cgtacgtgac cgcttttttc aatgcttcaa 3803221 tatgcgattt taaatattga atgcgttccg gatcatgaac cttgccgtcc tcctccagcg 3803281 tatccactgc gccaaagcca ttttcaacga tgaataacgg gatttggtat cggtcataaa 3803341 aacgatttaa cgtatatctc aacccggttg gatcaatcgc ccatccccag tcactcgaag 3803401 tgatgtacgg attttcgaca ccattcggca agccgccatt tacaatatcg ccagtgttat 3803461 catttttcac atcgcttttc acagttgttg acatgtaata gctgaagcct aagtaatcga 3803521 cggttccgtt tcttaaaatc tcatcatcgc cgtcttcgaa tgtgatgttg tagccttcgc 3803581 gttcaaattc cttcaacgcg tagcttggat aataaccgcg aacctgcaca tcagggaaga 3803641 aatagcgctg cctcatttct tcttcagcca gcatcacatc ttcaggattg gaggagaaag 3803701 gataaatcgg cacgtgtgat accatggccc caatctggaa ctctggattg atgtcttttc 3803761 cttttgccac tgctaaggcg ctcgccacta attcatggtg cgccgtttga tacatgactt 3803821 ccttggcgtt ttcgttttcg ccaaccacaa cacctgaatt cgtccatagg aacagcggat 3803881 tgttcacatc catttggttg ttaatctcgt taaatgtcat ccagtacttc actttatctt 3803941 tgtaacgggt aaagcaagcc tctgcgaagt tgacgaagaa gtccacgact ttccggtttc 3804001 tgaagccgcc atattctctt gccaggtgca gcggcatttc aaagtgagac agggtaatga 3804061 ccggctcgat cccatgcttc agcaattcat caaacacatc atcataaaac tgcaaaccag 3804121 cttcgttcgg ttcagcctca tcgcctttcg gaaaaatccg gctccagccg atggacgtcc 3804181 gcagacattt taatcccatt tccgcaaaca aagcgatatc ttccttgtat ctgtgataga 3804241 aatcaatggc ttcatggttt ggataaaatt cgttttcttc aatcgtgtca gtgatttttc 3804301 tcggcacgcc gtgcgcaccc gctgtcatca catcgacgac actcggccct ttaccgcctt 3804361 gattccatcc gccttcaaat tggtgggcag ctaaagcacc gccccataaa aaatcctttg 3804421 gcatgtttcc catgtttaat tcctcctcag cttacgactg taaatatttt ttgatgtaat 3804481 gcactttcct caatgtcttc aatgaaagct ttatcaaact caacaagcac ttcgcctttt 3804541 ttgacggtat cgccttcttt taccttcaag gaaaaaggcg tgccgtcaaa tgtcaccgta 3804601 tccagcccga tgtgcgcaag caattcgacg ccggacgctg aacgcaggcc aatcgcatgc 3804661 tttgtaggcg taaccatgac aaccgtaatg acgccgggat ggtagcatcg atttcacgat 3804721 atccttcgct ttaggggtag accgcttcag caccaatcga agtctggtag cgcagcgaga 3804781 agccccaatc acattctctt ccccgcctac ggcctctaaa atgtcttttg ctagtctcgt 3804841 ataatctctc actttccccg acatttcacc caccccttcg ttttggttac gctttcatta 3804901 taattgtaac ggtataattt atcaattccg aaacaaaata tttacgcact aactatcatt 3804961 gtaagcggtt tatgctataa ttttgacaag tgaaactaaa cgaataaatg aggaatgcgt 3805021 atgttaaaat accagcaaat cgcaacggaa attgaaacat atatagaaga acaccagctt 3805081 cagcagggag acaaactgcc agtcctagaa accctcatgg cccagtttga agtcagcaaa 3805141 agcaccatca caaagtccct cgagctatta gagcaaaaag gcgcgatctt tcaggtcaga 3805201 ggaagcggca ttttcgtcag aaaacataaa cgaaaaggct atatcagcct tctgtcgaat 3805261 cagggattta aaaaagatct cgaggatttc aacgtcacct caaaagtcat cgaactggac 3805321 gtgagaaagc caacaccgga agcggcggaa aacctgaaca tcggaatgga cgaggacatc 3805381 tactatgtca aaagggtccg ctacatcaac ggccagaccc tttgctacga agaatcctat 3805441 tacaccaaat ccatcgtgac gtatttaaac aacgaaatcg tctcccactc catcttccat 3805501 tacatccggg aaggactggg gttgaagatt ggtttttctg atttgtttct gcacgtgggc 3805561 cagcttaatg aggaagaagc ggaatatttg ggattagagg ctggactgcc gaagctgtat 3805621 atagaaagta tttttcacct gacaaatggg cagccgtttg attactcgaa gatttcgtat 3805681 aattatgagc agtcgcagtt tgtggtacag gctaatagtt ttttattata gggctcttca 3805741 ctacggtagg tggtcgacat gtacaaaatt atcattcctg ccatactagc catctttgcg 3805801 ctctggatac tcttacagat ttcactagag atgagcatcg ttaagaatcc aatgaactac 3805861 tttatcgtat tcattatctt tttcctcttt gtaaagatgg tgaaagaaaa acaataatag 3805921 tttgggcgat gcaaacagaa aaacatcctt cccttaacaa actcagccag tcacatgcat 3805981 taatcttgat gttaatgata tataggtgca cataaaaagc tacttcattg tgaagtagct 3806041 ccctttatta aaggcccatt ttgatccatc tagttttaga aaagcgaagg acaatcgcat 3806101 ttatgataat aattgaaact aaatacaaaa taataaataa aacatcatta ctcccaagtg 3806161 tcatgttatc agattgcagc actctttcta ttcgggggta catagtgtta cctgcctcaa 3806221 aaggagcaat gaaaccaaac gttttattgc ttatagctac taagataaca gaagtcatcc 3806281 aataaacgat actgacacct atactaatta atatattagg acataacacg cttatagttc 3806341 cgataattag aatatactgc agtataactg cagaaaataa aaaaagtaat aatgcaaaat 3806401 gcgaaaaatc atggtacatc aacgatatga ttagcaggcc tagcgttata aatgcaaaac 3806461 attctaaaaa taaaacagct atctttttat aaaagaaagt atagatgttc tctccaatta 3806521 acttgtaaaa gagaatattt ttgtttgaat actctctatt aataaagaaa gctataacaa 3806581 atgaaaataa catcaaacca aactgggtcg caacagtata ggagctaaag aaaaacattt 3806641 caggtgtaac attactgact ttatcgattc caacaagtaa aaaataaccc agcaaaaata 3806701 aaaatacaaa cattgctcct aaaataatga taactttgtt gctaatactc tttttaaact 3806761 ctaatttcat ctcaagcccc cactgtttta ttactcattt atatacactt caattaattt 3806821 atccactgaa tgatattgtt gaatttcttg gtgattaaat atataataat ccccttctat 3806881 cgcctttaaa tcagacaaat catgtgtaat gttgatgata atcttctcgg ggttctcctg 3806941 aatatacttg tttaagaagc catgaatctc tataaccgtt tttttgtcta atgaattcgt 3807001 tatttcatct aaaacaataa tatttttatc ctctaataag aaactgagca attttaattt 3807061 ttgcttttgt ccatcactca aatttttgat cagaactttt ccatcaatat tatccagatt 3807121 aagtaaatat gcgattttat ctatcatttt tgcatcaaat tttttactca aaaagtgtaa 3807181 taaaaagtcc ttagaaacat cattaggtat attcgacgag ctggatatta aagaaacatt 3807241 ttgacgaata tctctgccga ttcttttgct attattcaac aaaaagtctt tagcaagctg 3807301 tgatttaccg actccatttt ttccgacaac gtgattaatt ttcccgctcg aaaaatgcaa 3807361 gtcggtgtcc tgaagtaacg ttttgccttt cacttttaaa gtgtaattcg ctatattcat 3807421 atacatactc ctaggaaata tttgcataat aataaaatgt tctgccttgt gatttgttac 3807481 taatgtctaa gcttttgagg tacctctttc gtttccgatc cggaagcgaa agaaatgttt 3807541 ttagatggct aatttggaga tcttttactc tagtttacaa tatataatat ccaatgtaca 3807601 actgaattca ctgcaaggcc aatccctata atttgaatcg taagaactaa ccaatgattt 3807661 gtcttaaaac ggctatattc atctaagctc agaaaagcta aaagaatttt gtaaccatca 3807721 gaattcaata ttgggattaa gttccacaat aaagtagacg agaaaagcat aaatgccata 3807781 gttaatgctt cactggaaaa tgtaaattga tttattaatt ctaatgtatt tattaaaaga 3807841 taattgataa acaagccaaa taaatgaacg attatctttt catttcttga tagcatgtag 3807901 gtttcattca attggacata aaaagcagga aatacataaa aattcagttt gaatcccact 3807961 ttatcaaagt ttttcccgaa aaattttaag gaataaatat gtcccagttc atgaagcact 3808021 atattcatta taaaataaat aactataatt atccacattt tccagccgta aaatactgag 3808081 gacaatccat tttgcaattt tattaaatga atataattta atatgaacat gagagccgta 3808141 aaggataaga acagataaaa aaactttggt gatactttct ctttatacat tttaaaacgt 3808201 aataattgtt tatctgacag agaatttaaa ctatttttat agtattctcc gctttttttg 3808261 tcttttataa atacgttgtt ttgcacaagc acttcatatt tttcatcttc atactttaaa 3808321 attttcatta tagtattttt ccatataagg atagaagtag tttatttttt ctgcagagtt 3808381 gaataaggaa ccacaaactc cacaaataga ggaaaattca taaggaatgt caaattcctc 3808441 tattttgtta ttttctttta aaatattcaa aaaccatttg aatccttctt ttctaagaat 3808501 aaataatagc aaattggaat ttaacttttc cacggttctt tcgaaacttt ggttatattc 3808561 ttcccttagg gttattttcg tttcaaaaat agcaggggaa caacatggat aaatttctcc 3808621 atcatgatga tatacaatgt catatccggg acaatgtaag gaatcttcat cttcaagact 3808681 gtaaaattta tgtatgtttt cttgcttaat tctagtttta gcagcgccaa ctgatatcat 3808741 tggaaatttt gttatcttta cacctaagat tgaatccccc aattcctcta aaatgtggtt 3808801 ggacattttg tctttggtaa ctgccatatt aagagaaata tcgatatcag ggtatttcct 3808861 gctatgttct aatatgtttt taatactgga agacttgaca aatggagcat ggtactcatc 3808921 ataacttata gtcagtgcta tcacatttaa agaattcata tcatgaaagt actcctggac 3808981 ctttttcttg ctcaaacccc aaaatccatt agagatcaac gttatttgtt tttcatatgg 3809041 tttaatgatt tccattagtt cttttaaaaa tttataatct aaaaaaactt ccccacctgt 3809101 aaaagaaatc acttgaatgg ttttgttttt tgcaaattca gttactaact ctcttatgta 3809161 ttctttttcc atcctggttg ttgaagttgg tgaactagaa aaacaacaat ggtcacagga 3809221 tgcattacac cttgaatcta aattgattga tactgtttta ttatacatga aatatccccc 3809281 aacaaatggt aaaggagagt tagactctcc tttgtacccc tctaattaat gaccacttcc 3809341 aagaatccag cgattttctt ttgattttac aaaataccaa agatcattca cttttgctaa 3809401 cttttgtgat tcatctaata gacccttaaa ttctaagttt ttcacagtct cattgttagt 3809461 gatttccttt ttcatattat ccctcctcct tttctaatat aaaccaatta ttctatatca 3809521 ttcaatacat gtcaatatat tgtacctaaa aaatctgaaa aatgtcacta ttcttggtat 3809581 ataaagccta tagtcctcta gcccctctaa gctataccga atgaaaggcc atagtttgat 3809641 ttaaagcttc gtaatgaaaa gtaaaacatc aatattgact acactagtta agggatatac 3809701 agattttaag tggaagaaat gaggcaaaca atcttaccct aaaccaacct gtactgaaaa 3809761 gctgttttaa gctcttgctt accccatttg gcacctcttt ctctcgtttt aattgtctct 3809821 aaaagcagtt atgcggtact atcatataaa ggtccaatgt ttaaaaataa tgtcatactt 3809881 ttaaattcac cttatcatgc acatgctcat aaagaggggt ttattctaaa aaggggatgg 3809941 acggttttgg aaagcaagta cctagatcta ctcgcacaaa aatacgattg tgaagaaaaa 3810001 gtggtaacag aaatcatcaa tttgaaagcg atattgaacc tgccaaaagg caccgagcat 3810061 tttgtcagtg atctgcacgg agagtatcag gcattccagc acgtgttgcg caatggttca 3810121 ggacgagtca aagagaagat acgcgacatc ttcagcggtg tcatttacga tagagaaatt 3810181 gatgaattag cagcattggt ctattatccg gaagacaaac tgaaattaat caaacatgac 3810241 tttgatgcga aagaagcgtt aaacgagtgg tataaagaaa cgattcatcg aatgattaag 3810301 ctcgtttcat attgctcctc taagtatacc cgctccaaat tacgcaaagc actgcctgcc 3810361 caatttgctt atattacgga ggagctgtta tacaaaacag aacaagctgg caacaaggag 3810421 caatattact ccgaaatcat tgatcagatc attgaacttg gccaagccga taagctgatc 3810481 accggccttg cttacagcgt tcagcgattg gtggtcgacc atctgcatgt ggtcggcgat 3810541 atttatgacc gcggcccgca gccggataga attatggaag aactgatcaa ctatcattct 3810601 gtcgatattc agtggggaaa tcacgatgtc ctttggatcg gcgcctattc cggttccaaa 3810661 gtgtgcctgg ccaatattat ccgcatctgt gcccgctacg acaacctgga tattattgag 3810721 gacgtgtacg gcatcaacct gagaccgctg ctgaacctgg ccgaaaaata ttatgatgat 3810781 aatccagcgt tccgtccaaa agcagacgaa aacaggccag aggatgagat taagcaaatc 3810841 acaaaaatcc atcaagcgat tgccatgatc caattcaagc ttgagagccc gattatcaag 3810901 agacggccga actttaatat ggaagagcgg ctgttattag agaaaataga ctatgacaaa 3810961 aatgaaatca cgctgaacgg aaaaacatat caactggaaa acacctgctt tgcgacgatt 3811021 aatccggagc agccagatca gctattagaa gaagaagcag aagtcataga caagctgcta 3811081 ttctctgtcc agcattccga aaagctgggc cgccatatga attttatgat gaaaaaaggc 3811141 agcctttatt taaaatataa cggcaacctg ttgattcacg gctgtattcc agttgatgaa 3811201 aacggcaata tggaaacgat gatgattgag gataaaccgt atgcgggccg tgagctgctc 3811261 gatgtatttg aacgattctt gcgggaagcc tttgcccacc cggaagaaac cgatgacctg 3811321 gcgacagata tggcttggta tttatggaca ggcgaatact cctccctctt cggaaaacgc 3811381 gccatgacga catttgagcg ctatttcatc aaagagaagg aaacgcataa agagaagaaa 3811441 aacccgtatt attatttacg agaagacgag gcaacctgcc gaaacatcct ggcagaattc 3811501 ggcctcaatc cagatcacgg ccatatcatc aacggccata cacctgtaaa agaaatcgaa 3811561 ggagaagacc caatcaaagc aaacggaaaa atgatcgtca tcgacggcgg cttctccaaa 3811621 gcctaccaat ccacaacagg catcgccggc tacacgctgc tatacaactc ctacggcatg 3811681 cagctcgtcg cccataaaca cttcaattcc aaggcagaag tcctaagcac cggaaccgac 3811741 gtcttaacgg tcaaacgatt agtggacaaa gagcttgagc ggaagaaagt gaaggaaacg 3811801 aatgtgggtg aggaattgtt gcaggaagtt gcgattttag agagtttgcg ggagtatcgg 3811861 tatatgaagt gaggggtgtg gggttcaggg atggtgatat gctgctcccc taaaagtaga 3811921 tagatgaatt ttagaaaatc tgtttgcctt ggggagtttt ttcatggctg gacaattata 3811981 ctacaaggaa gaaatactaa tacttataga atgtaattgg gtaatgattc ggagaaagag 3812041 gttgcgaaat aatatggtat tacactgaaa caattatcaa tggagaacat gcacgatata 3812101 gccgttctat attctccctc tattatggca ctcattagta gacataaccg taaaaaaatg 3812161 cactcaaaaa aagtccattc tatataactc tcgctagggt ggaccttttt caacattcaa 3812221 agtactagat tttttctagt gaaagaataa gaaaagacat aagttctatt ttatcactct 3812281 gttataggtt aagttattac ggtgtttcat tatatactga atttaaacac ccttgacatt 3812341 atgggaattt ttaaaacagg ttaaaaggaa gttctataag aactccctag tttaatatta 3812401 tttggtcaaa atctaaaacc aaaaaatcta tttttatctt cattgtttct atctaatttt 3812461 gcaacaatca tacctttcga ctctaattct tgaaggtcat ctaataataa ttcattttta 3812521 tttattgtta caaaatattg tccgatccta ttctctaaca gacttgaatt gatatgtttt 3812581 aataatgtac cttttacatg aggatcagga ttagaataag atccgtcatg aattaaaata 3812641 ttcaaactac acttatttat acacctgtat aaaaaccaag taagatcaaa tatatttatc 3812701 ttcatatgga gtctaccatg tgaacgttca tccggtatag aacaagaaat tttgatcctt 3812761 cctgtagttg attgttttgc gttacttatt ctattatcat attcaaaatc taaaaatcca 3812821 tgttggttgt atgtaacatc cattagatta ttaaaaagct tctttaactc actaactata 3812881 gcgctataag attgaaactc atcataatac attgaattaa ctcttaatat ttcatgttga 3812941 agttcattaa tcttatcaaa aatatggttt tttttatcgt agtcactaat tctcaatctt 3813001 acttccgcta actctatttc tttccttctt tgttcttcca tcacaatgga aatatcctca 3813061 atgaaattgt tactctttaa aattctggca cttgattcca gttgttctgt taatccttgc 3813121 tttttgatat taagtttttt taaatcggct tgtattttaa caattttatc tttaaaataa 3813181 ctccctctac tttctaccat gaaattatag aactcttgga ctttattata attctgtttt 3813241 acttcctctg gaaaaaaacc tacaatatct tcatagaatt tttctatatt ttctaattct 3813301 ttaatcttag ttactttttt atttaaatca tctatatttc tttgatattg tttacaaata 3813361 tgttcatttt caaatatttc attttgtatt ttattaagtt cacttttaat ttctgagtac 3813421 ctatttgtat cattattata tttattggca gtcttagttt gatagataac tctattgtaa 3813481 tcctctatct catttattaa ttcatcttcc ttaactttta aatcgccaat gttaatattc 3813541 attgattcaa tcaattttat ttcactattt aatttttcaa tcttatcccg aaaaaccttt 3813601 atgttttttt ctgtatgagt tggtaaagta aaaagatagt taagtaattt atattgtttt 3813661 aaccctcccc tattcggtaa aactatatca ttaaaccctg tcttttcgtc tcttataata 3813721 tactccctta acgccgcaaa agttatatcc tctttctcac cctttaaaat ttccttttca 3813781 ataaattttt tatatacact tatactaact tttttccatt cctccaaatt aaaagttaaa 3813841 gaagtatcat gtaatgtata accatgttta ggagaattaa aagatctagc aaggaatact 3813901 tgatttccat caatttccac attcaaaaca ataaaaacgt ttttattgag aagaatttca 3813961 tttgtcgtat aaaaatttga tatagtcttc cctagtaaaa aggagatgca ttcaatcatc 3814021 gttgacttac ctacaccatt agtctcttca tgatcttctc tcttttcacc aagtattata 3814081 tttactccta cagcattaaa tttatactct ttcaaaattt cttgggaatt gcaaacaaaa 3814141 agatttttta taatcataac aatcactaac tctccgttct gctaatcata ttttgattaa 3814201 aagaaacttt acctaatgaa tataaaaaag ttaacgataa atacagtatc cgttcaatat 3814261 tcaaatttat tataatacct tgactcttag cataatcaag aaaaagttga tcaatatgtt 3814321 tttccttctc taacagttca taaagtatct ttgatgagta taaaatattt tcttccacag 3814381 cattatattt agttaataaa aaatgattca tttctggcct ctccgccttt tcctttttta 3814441 aaggagaatt attcactaga ggaataagat catttccaat ttgaatgttt ttaaactcat 3814501 tttctaataa aacataagag tatttgagaa tattttcagc tgtttcaatt ttaagatcaa 3814561 tcattcttaa cacttctttt gttatcatta aaaatctcac attcataaat gcaccaacat 3814621 gttaaaatct taatgtattt tttcgttaaa gcctttgaat atggtaaaac tgaatgacat 3814681 tctagataaa tctcattaac aatttttaca aatatctcat ctccattatt atattgatta 3814741 tgaaactcta gatatttgtc tactatcgtc tcagcaatca attccttttt atcagcactt 3814801 acatacgaag tggaatccat tatatggttt atcacaccaa aatactcaga ataactatcg 3814861 aatttccgtt taaaagtttc cccacttttc atatcataaa attttttatc taaaccaatt 3814921 tgattatcaa aattactagt aaatgtttta taactttctc tatactcatg aaaatctata 3814981 ataaagctct taaactcatc ttcatcaatt ttatcatcgt tatcttctat ttctttttca 3815041 ataaggctct ctaatctatt aatcttataa tttaacttcc cttcctgtag tctccttcct 3815101 ccttggttgt tttttgacca gtatttatat tcggtattcc aaatgtagta tgttacttct 3815161 gtctcgccat tatctaaatt cacatccacc gaaataaatt ctggagtagc atactcatcc 3815221 tttataatgg ctccacttac taattctaag aatggatttt catttgtatt tgcagtaata 3815281 ttaaatgaag aatcatgtac atgtcctgcc aaatatagat caataaagta atcatcaaaa 3815341 tgtgccttta ttgattctct ttcggaagat tcaatacaac ctaacgtatg gtgcccaata 3815401 gctatattta ataccttgcc cttatttttc tctttgttca tcttccttat tgctttatat 3815461 aatttcatct gtgcagttaa taacgttcct tcttcacctt ttttatctga taacagacat 3815521 gtatttattg ataaaacatt atacttctcc gattgataca aaaaatgcaa atcttcttcc 3815581 ggatatttaa cacccataaa atcttcataa aaatcgaaaa atttcctttg accttccact 3815641 aatatatttg tagctttttg atctagttta tccaacattt ctgaggggtt aggagatttc 3815701 ataatactat caatcaaaag tgtcctcgtc atgtctctag atatatcgtg atttcctggc 3815761 actaagtgta cgttattctt acttaatccc atacttttaa taattccatt aagatattct 3815821 ttaacatctt cgttatacac atcacctttg tgtgctatat ctccagttaa taataaaaaa 3815881 tcaaaatctg actctcttct taaaacttct ataaaatcta ataatttatc tctcattaca 3815941 atagtgtcat aattttgaaa ctgaaaatgc aaatcagaaa tttgtaaaaa acgtaccttc 3816001 aatacaaaca tcctctcata agtatattta tcccctatat atttctagaa aactttttat 3816061 tctatatcat ctttactctt taatatatta agactctttc cacaccatca aataaattat 3816121 aacctaaaca taactcttta ctcattttag tattgtattt aagtcaaaca ttgcattggt 3816181 tgctgaaata ttatattcat tgaattattc cattaaatag cttttagttg aactttagtc 3816241 tttctgtaat ggtggagatg ctcttactta tgataaggct ccccacgatt aatccgaaaa 3816301 gcccgataaa tctgctccac taaaataagc cgcatcaact gatgaggaaa tgtcatcttc 3816361 gagaacgata gcttctcgtc cgctcgcttc atcaccgtgt cactcaatcc gagtgatccg 3816421 ccgatgacga aggtgacttt gctttttcca taagtagcca gcttatctat tgtatcggct 3816481 agttcttcgg atgttttcat ttttccttcg atggcgaggg cgatgacgtg ggcgtcgggg 3816541 ctgattttgg ataggatgcg gtcgccttct ttgtctttta tgattttcat gtcctggtcg 3816601 cttaggtttt ccggcgcttt ttcgtccggg agttcgatga tgtcgatttt tgcgtaggcc 3816661 gaaagtcgtt tggtgtattc ttcaatgcct tgcttgaggt atttttcttt tagttttccg 3816721 attgtcacaa tattgatatt cacaggtcat ccccacttta aaaacaagtt attcatatat 3816781 gttgtccaca attgtggata tcttttctgt attttgtgta agatcattcg ttccccacta 3816841 tatatactgc ggggtctcca cataattcac aggctgtgga taaactgtta gtatgttcga 3816901 tttttctgat ttcgggcggc agctcgtggt cgtctatgta catatccagc accgtttcga 3816961 tgtgttcttc acaagaataa tacgcttgtt tcatgttcaa atcctccgat gttttcttcc 3817021 atttttacaa atgttctctt ctcaatataa cctatttatt cacatgttag tagtgcttcg 3817081 ggctgagttt tatccacaat tcgacaaaca agctgttgat gactctattt cgctcgtgtg 3817141 ttagtttgga tgtaaccgat gtgtggggag gtctgcattt gcgctttaga tgggtttggc 3817201 tttttgtgat tatgttgctg cttgctgagt gtcagccatc ttattgggtg ttggagaagg 3817261 atcgaatcgg tgaaggcagt ccagacttag aaatatacgc taattatctc caaatgcatg 3817321 atgacgtgaa aggatatcaa gtcttcacca tatcagaagg caaaaaaatg gtcgtcgtgt 3817381 ctctcggaag cagcgagaaa gataagaagc ttgaagtgtc ggacgtcaaa ttctcatcta 3817441 aagaaacgat tgtaactgtg gagcgaaaac ctgctcctac ggcaaatgag aaaaaccctt 3817501 ttattttgat tggactggac aaaattgaag gggatttaat tgttcaagac gaaacaggag 3817561 atcgctttga agaaacggat taccagcaat aaagccggcg ttctgagaac gtccggcttt 3817621 ttcttttact tcaatgtccc atgcgggtcg atgacgaatt ttttggctgc gcctttgtcg 3817681 aagtcgctgt agccttttgg cgcgtcgtcc agagaaataa cggtggcatt gacggctttt 3817741 gcgatctgcg ctctgccgct caggatcgct ttcatcaaat tgcggttgta tgtcatggcg 3817801 ggcgtttgtc cggtgacgaa ggtgtgggct ttggcccagc cgagtccgaa gcggattttt 3817861 aatgagcctg ttttggcgtc cgcatccttt gcaccgggat cttcggtcac gtataagcct 3817921 ggaatgccaa ggctgcctcc gacctgggtg acgtccatga ttgagttcag cacggcggct 3817981 ggcgcttctc cttgattgcc gtgcccagat gcttcaaagc cgacacagtc cactgcagca 3818041 tcaacggttg gttcacctag tatttgttca atttgctcgc cgaggcggtc gtgtttttgc 3818101 acgttgaccg tttcacagcc gaagcttctg gcctgtgcca gcctgtcttc gttcagatcg 3818161 ccgacaatca cggtagaggc gcctaggagc tgagcggagt gtgcagctgc caagccgaca 3818221 ggacccgctc cagcgatata aacggttgaa cctgtttgca cgcccgctgt ataagctcca 3818281 tggaagccgg tcggaaaaat gtcggacagc atggtcaaat cgagaatctt ttctagcgcc 3818341 tgttctttat cagggaatac caaaagctga aaatcagcgt atggcaccat gacatattca 3818401 gactggccgc cgacccagcc gcccatatcg acgtagccgt aagccgatcc cggccggtcc 3818461 ggattgacat tcaggcacac atgcgttttc tgcgttttgc acatcacaca gcgtccgcag 3818521 gcaatattga aaggaacgga tacgatatct ccttttttga taaattcaac atcacgcccc 3818581 gtttcaatga cttctcccgt aatttcatgc ccgagcacca agccttctgg cgccgttgtg 3818641 cggcctctga ccatatgctg gtcgcttccg caaatgttgg ttgtaatgac tttgagaata 3818701 accccatgct cacattttcg attcacattc gccttcggga cgccgggccc gtccctcaag 3818761 attaactccg gataaccgat atcctccacc gctacagtcc ctttgccttt gtacacaacc 3818821 gctttgtttc ctgtcaacgc cattcctccc attcatgtgt ttggactctc cgtccttgaa 3818881 catgacttcg gttcggcatg actctttccc tttttcacga ctgttttttc tgtattctta 3818941 caacaacaaa tatgccaaga aagcatccaa taatggttcc gccgatgtct aagaagtcga 3819001 ctttacatcc atttaacaag aacacagtaa tggccgaaac caggcagatc ataactgcca 3819061 gaagaataac ccgatttgtc tgcatgtaat tcctcctttg gattcgtttc taaaccatac 3819121 ccaaaatcct ctgcaaactt cggttcaaca aaaaaagaga cttcacacca gtctcttcat 3819181 aaacagagat cactcaaaaa atttcctgag aaataatgtg gcaacactcg ttactaacgc 3819241 aattgccgta tacataacaa cccaaaatat gaatgagcta ttccccgaag ctaacgtaac 3819301 taacaatatc aagctcgtga taagaacgat gagcggtgcc acccaaaatc ttttaaataa 3819361 aaaatgaccc gctataccaa atacacctgc gacgatcgga aaaccaaaaa cgataaataa 3819421 aacggcgatg gctcccatac taccctcctt gccttaaaac ctcttcatca cctcaacatc 3819481 atacagcttc aaatgactct tcggcgtcac gacatccttt accttcccaa tctctttttc 3819541 tttcattttc tttccggttt tcaggctgta ctgttcaatg taggcaggct tgtgatacgt 3819601 gtatgtgaag aaatagaggc tgctgccttt ttgggtgatt tctttgaatt cggctttcat 3819661 tttgtccggg gaaagggtga agacgatgct tgtttttcct gtcttggcat cgattttgtg 3819721 tacctttccg aagccgtcaa tgaaatacag gttcccgtca taagggaaaa agctgttttt 3819781 aaagctgaag ggcatggagc tgtatatcgt ttgttcgtcg tttttgtatt cggcgatatc 3819841 gtgcagctct acttcgccgc tttttttgtt gatcttgacc atttgataga gatcgtgggc 3819901 tttttggccg cgaaccataa catacacagc ttggtcgtcc acggcaagtt gggattcgac 3819961 tgaggctcct tcccggtact gccattccgt tatgctgaga taggtaagct tcttctgatc 3820021 tgcttgaatc tgaaggagct gatagccttt tccgtcatct gtcgggacga gtgcgtaaat 3820081 ggcgccatca tggaaaccgg aggctcggat gtagtagggg atgacgtctt ttttccactc 3820141 tccgtccatt tggcggtaca gctctgagcg gtatccgtct ccctttttgt cgtagccgga 3820201 gttgtataag gtgtaaaagc cgtccgtgtt ttgcagaaag cccgcgctgt cgcctgtgtg 3820261 ctgataggtt cttttatggg agcgcaggcc gtttttgatc gtataaatcg tgtttttgtc 3820321 ctccagcatc acgctgtcac cgtgaacctt tgctgagccc agctcaaggc ccttcatctg 3820381 aaaggaagac agcgtcccgt catggctgat aaacagggcg tagcttttcc cgccgccaaa 3820441 tgcatcttga tccgcagagg atgagaaata cagcaggact tctttgtcat ccaggaaatc 3820501 gggatttctg agatcctgct gactcacggt tttatggctt ttgagaggag aaatgaagac 3820561 aaatagtgcg attcctgcga gaatcagcat ggcgatggta atcatccact ttttcatagc 3820621 cttctcctta gtaaatggtc ataatggttg tcgtataaga agaactagtg atgtcgcgcg 3820681 gatacacgcc taagcctccg ttgctgtcta tatcaatccc tgctttcagc aaaaaggcag 3820741 accataggag ctttgaacag tttttggcgc cgtcatggcc ggtatttctg ttattgacga 3820801 agttaaatga gtatgggtcg ccgacttttg ataccgccca gtcggcagca gctgtttttt 3820861 gagatgagga tacgctgacg gtttgcacaa tggagttgtc ttccacgtct ctggcattat 3820921 acgcgatctg cctgacgccg tcgctcggga cagattcaac aattttgtca gcggcggagt 3820981 acatgccgac atggccgtga ttgtagtagg ctgtgtagga gttcgtgtaa tagatattgc 3821041 ctttcgcgct tgtcgggagt tttttcgtgc cggacgagcc gcccatgata gacatgccgc 3821101 tttccttggc gagccggtcc ccctctgctt tatcagccgt gatctcctta tagaactgtt 3821161 ttaggataac gtcctgcttt acgtgctgct gtttggcaat ctggctggca gatttcatga 3821221 tttcttccgg tgtcgtgcct ggctgcagtg cggcgatttc ttcagcataa tttgtggtct 3821281 ttacggcttt ggcgggagta acaaacaggc cgccgcacat tgtgagcgct accaaaaaca 3821341 tcgacactcg tttcttcaac ttcattacat ctcctctttt cttgtgagtg taggaaaggt 3821401 aatttcctca cccacattat attaggaaaa taaggaaagt aactaggtta tttacagaat 3821461 ttttagaaat cgtttacaga aaaaggcctt tatcaggccc ttttcgttaa agcttcttgc 3821521 tcatcactac gtctgtttct tgaaatccgg tttgctcata tagctttcga gccgtctgat 3821581 tatgggcaaa gacatgaagg gacagcttgc ggattcccat actgcgtgcc gcttgatcta 3821641 atgccgccaa tgcttgcttt gcgtagccct ttccccgata cggttcatat aacccgaaat 3821701 cataaataaa cgcttcctgc tgcggatgct ccggttcagc atgtatccag agccagccaa 3821761 cgatatcctt ttcattcagc ttgaggctcc acaaatggtg atggggtgtt tcgagccctc 3821821 tcggaagcag atcagtaaac acctgcttag acaaaagctg ggcatcttca ggcagccatg 3821881 ttcccgcttt taccttttct tccgcgtaat gctttgttgt gtacgtgaga taagaccgaa 3821941 attcttctgt ctgcataggg gttagcataa ttgtcatatc atctctcctt catatattga 3822001 ctagaggatt ttacataaaa tagaaagagg tgttactatc agaataagca actgagattg 3822061 ataagtcact agagaaagga gtttcacatg aataagatcg cacccgcaga aatcgctagc 3822121 atgctcaacg attggtacct tgccatcaag aaacatgaag ttgaagaatc ctcccgttta 3822181 tttgaagaag tgaagccttt attggatgac atggaagagg atcaggaggt gcttgcctac 3822241 ttctccttat tggaactgcg ccacaaggtt ttgcttcacg aggcgagagg acagggcttt 3822301 cagcatgagg agccttctca tatgaatgct acgtctgaca tgctgaaata ttactttttt 3822361 ctgtttgaag gcatgtatga ggcctataaa aataattatg acattgccat tgggctgtat 3822421 aaagatgcag agcagtatct cgacaacatt cccgatccga ttgaaaaagc cgaatttcac 3822481 ctgaaggtcg gtaagctcta ttataagctg ggacaaaata ttgtgtccct caatcataca 3822541 cggcaagcag tcaaaacatt cagagaagag acagattata aaaagaagct ggcttcagcc 3822601 ctgattacca tgtcaggcaa ttttacagag atgagccagt ttgaagaagc tgaggcttat 3822661 ttggacgaag caattcggat cacgagtgaa ttagaggatc atttttttga agcccagctt 3822721 ttgcataact tcggccttct acatgcgcaa agcggcaaat cagaagaagc ggtttcgaaa 3822781 ttagaggagg ctctacagaa cgatgagtat gcccgctccg cctattatta tcattctgcc 3822841 tacttgctga tacgagagct gtttaagatc aaaaagaaag aacaggcctt atcttattac 3822901 caagacgtga aggaaaaatt gactgctgag ccgaatagaa tatgtgaggc aaaaatagac 3822961 attttatatg ccatttatgc agaagggggt catgcggaaa cgtttcactt atgcaaacaa 3823021 catatggatg acttgttgtc cgagaaagag tatgacagtg taagagaact ttccattttg 3823081 gctggcgaac ggtataggga acttgagctt tacaaagaag ctgcccactt tttttatgaa 3823141 gcattacaga ttgaagaact gattaaacga acggaggtta tataaatgaa aagatttctg 3823201 attggcgcag gcgtcgcagc ggtgatttta tcaggttggt ttattgcgga ccatcaaacc 3823261 cactcacagg aaatgaaagt cgctgagaaa atgattggat aaatgaaaaa cccccgcggg 3823321 atgcgggggt tcaatttaac gaaagaatcc taaaacggtt tgtagtttta ggattctttc 3823381 atcttttcag cgtgattgaa aacccttgaa gtctaggaag aacgagcatt ggagcgcagc 3823441 gaatgtttgg aattcgtgag caccgaagcg caggcctgac aacgaatgcg agggtttgtc 3823501 gacacgctga aacccccgcg ggtgcggggg ttttcttatt acagcagctt cttccctaac 3823561 agggattcta cgagctctac tgctgttttg cccgttttgt ttttgtgatc aaggatcggg 3823621 ttaacctcaa cgaattcggc tgaggtaatg atgcctgcgt catacagcat ttccatagcc 3823681 aaatggctct cccggtagct gatgccgccg acgacagggg ttccgacacc cggtgcgtcg 3823741 ttcggatcaa gtccgtccag atcaaggctc agatggacgc catcacatgc tgataaataa 3823801 tcaagggttt cttcaatgac ctttgtcatg ccaagacgat cgatttcgtg cattgtgtac 3823861 accttcatgc cgctttcctt aatgtacttg cgctcccctt catcaagtga ccgggcgcca 3823921 atgatgacga cgttttccgg tttgatttta ggcgcgtagc cttcaaggtt aaccagtgac 3823981 tcgtggccaa tgcctaggct gaccgcgagc ggcatgccgt gaatattgcc cgatggtgaa 3824041 gtttcaagtg tattcaaatc gccgtgcgcg tcataccaga tgacgccgag attatcgtaa 3824101 tgcttcgctg tgcctgcaag cgtgccgatc gcaatactgt ggtcaccgcc caggacaagc 3824161 gggaattttt tctcttcaat gactttgttg accttttgcg cgagtttttc atttcccgcc 3824221 aaaacggaat tcaggttttt cagttcctcg tcatttttga ttttttcgcg attgatcgga 3824281 atgtcaccga gatcttcaac cgtatacccc atgtctgaca gcctctcgat cagatgagcg 3824341 taccggatgg cactcgggcc catatccact ccgcgtcgtg cttgtcctaa atccattggc 3824401 attccaataa ccgaaatcgt tttatccatc tgtgattcca cctcaacatt taagataatg 3824461 tcctatgcgg gttataacaa agatgacttg cggacaacgt ttttaaagct ctagctgacg 3824521 atttgcctgc tggcgttttt taatgacgac atgataaatg atgtagcaaa tgatcataaa 3824581 cggtacgccg caatacagcg cgatacgctg ctccggatca aatgcaagac tgatgagcac 3824641 gaccgtattt aacgttaggc cgatcagcgg aagcaccggg tacagcggtg ttttaaattt 3824701 caaatcttct atcttcccgc cctcacggat atatttgcgt ctgaacatga tttgggaaag 3824761 cgagatcgta atccagccga cctgcgcgct catgcccgcc aaagataaca gtaccatata 3824821 tacggtttca gcctgcgcaa actttgtcag aagtgatagg caggccacag ccatcgttac 3824881 gattaacgag tacatcggta caccgcgctg atttgttttg ccaagcgctt tgaaggcttg 3824941 tccttcattc gccatcgcgt acagaatacg tgttgatgcg tataaacctg agttcgcaac 3825001 agataacagt gcgattaaaa taacaaagtt catgatatca gctgcatatg ggattccgat 3825061 ttgctcaaat acggcaacaa atggactttc cacgacaccc gcctgtttcc acggaatcat 3825121 gccggcaatg acaatgattg aaagcacaaa gaacacaagc gttctccata ctgtctgttt 3825181 gatggaccgc ggaatcgttt tttcagggtc ttcactttct ccggctgcaa ccccgatcag 3825241 ctcagtcccc tgaaacgcaa agttcacagt aatcatcgta atcagcattg cctttatgcc 3825301 gttcggaaat aacccgtctt cataaaaatg tgtcaaaaac ggcgcctgct ctccgccctt 3825361 cagatcaatc aggccaaaca tggcagctcc gccgagaata ataaataaaa ggataatcaa 3825421 aattttaatg cctgagaacc agaattcaga ttccgcaaag gcttttgtgg tgatcgcatt 3825481 taaaataaac atcagtgccg caaagaccag acaccagatc cacacgtcta tatgcggaaa 3825541 ccagcgttgc atcagctgcc ccgctgataa aaattcaatg gcgcatgtaa ccgcccagcc 3825601 gagccagtac agccagccga acgcaaaccc gaaggccggg ctgataaatt tcgtggcata 3825661 ggtctggaag gaccccgaca caggaaaggc gactgccagc tctcctaagc agagcatggt 3825721 caaaaacatg ataaagccgc ccactaaata ggacagaacc gcgccgagcg gtcccgcttg 3825781 gttaatggta aacccggttc caaggaagaa accggttccg atcactccgc ccaatgaaat 3825841 catgaacaaa tggcgtgatt tcattgtccg ctggagctga tttccgttat cttggtttgt 3825901 attcacattc tgcacccctt cagcaacttg tattggatct aagctggaac atctgcatgg 3825961 tgctatccca gtttgctgtc caaagagtct ctatctattt aatataaaat tcacttcttc 3826021 tcataaagat acattatact aaaatactgt agctgagcaa atagggagtg ctgatttttc 3826081 tgttgtaaat ttatacaaac gaagtgaata tcccgccatg gtgcggattt atgcgtttcg 3826141 cagcacgtgc ttaattttct ctatcgccca atccaagtcc tctttggaaa tgattaatgg 3826201 cggtgcaaaa cgaatgactg tatcatgcgt ttccttgcat aaaagtccct cttccttcaa 3826261 acgctcacaa tacggacgtg ccgcttcagt caattccaca ccgataaaca gccctctgcc 3826321 gcggacttct ttaatgacag ggctgtcaat actctcaagc tcgcttttaa agtattcacc 3826381 aagttcaaga gaacgatccg ccagcttttc atcctccagc acttctaatg aagcgataga 3826441 cactgcacat gcaagcgggt ttccaccaaa tgttgagccg tgtgagccag ggttaaacac 3826501 gcctaggatc tcgcggtccg ccgcaatgca agagatcggg aacacaccgc cgccaagcgc 3826561 tttgcccaag atatacatat ccggaacaat gccgtcccag tcacaggcaa acgtcttgcc 3826621 tgtacgtccg agacccgtct gaatttcatc cgcaataaac aagacattct cttccttaca 3826681 aatcgccgcc gcttcctgta aaaatccttc aggcggaatc acaatgcccg cttcgccttg 3826741 aatcggttca aacaagaatg ccgctgtatt cggcgtaatg gcctgtcgaa gcgcttccac 3826801 atcgccgtaa ggaatgagtt tgattcctgg aagcatcggg ccgaatcctc gtttatattc 3826861 ctcttcagaa gaaagagata ccgccagcat cgtgcggccg tggaagttcc cgacacatgc 3826921 gataatttcc gcttgattgt cagctacgcc cttcacttca tacgcccagc gtctcgccgc 3826981 tttcaccgcg gattcaaccg cttcggctcc tgtattcatc ggcagaatca tctctttgcc 3827041 tgtcagttta gctgtttttt cgtaaaacgg cccaagctga tcgttatgaa acgcgcgtga 3827101 cgtgagggtg attttatcag cctgatcctt taatgcctga atgattttcg ggtgtctgtg 3827161 cccctggttt accgcagagt aagcactcag catatccata tattcattgc cttccgggtc 3827221 ctttacccaa gcacccagcg cttcagaaat aacaatcggg agcgggtgat aattgttggc 3827281 tccgtaatga gacgtctgat caataatttc tttggattta gataaagctg tcatatttga 3827341 attccccctt gttttctgtt tcaacatgtt atcctgcttt ccctttatat aaatgcaagt 3827401 tctgtgccaa atcaagaatt cgtgtgtttt ctacaatttt cgaggacaag gtgcaaaaac 3827461 attctgatat ttcgagcgaa aatttcagca agtgcaaaat tcttttgcat atcctctccg 3827521 tttttttata aaatagaagc aatattaaga aaataattga gggaggttca tacagtggtc 3827581 aaagacagcg aattcctcac attggttttt cagagtattt tagatgaaat cgatgttggc 3827641 ctgcacgtgg tagacgagca tggaaacaca atcgtttata acaataaaat gatgcagatt 3827701 gaagatatgg agaagcatga cgtcttgaat aaaaacctga tggatgtgtt tatgttttca 3827761 aagcagcagg acagcacact ggtacaggct cttcaggaag gcaagacgat taaaaacgtc 3827821 aaacagagct atttcaataa taaaggccag gaaattacga cgatcaatca tacatatccc 3827881 atcgtccaag acggcaaaat caggggcgcc gttgaaattg ccaaggatgt gacaaagctg 3827941 gaacggctga tcagggagaa tatgaacaaa aaaggcagca caacctatac gtttgacagt 3828001 attctcggca ccagtccggc cattcaagac gtcatcgaaa acgccaagcg ggcaacccgt 3828061 acgtcatcat ctgtccttct agcaggcgaa accggcacgg gaaaagaact gttcgcgcaa 3828121 agtatccata atggaagcga tcgttctggc ggcccgttta tttcgcaaaa ctgcgcggca 3828181 ctgccagaca gccttgtgga aagcattttg tttgggacga aaaaaggcgc gtttaccggc 3828241 gctgtcgacc agcccggcct gtttgaacaa gcccacggcg gcacactgct gttagatgaa 3828301 atcaactcgc tgaatctcag ccttcaggcg aagctgctgc gcgcccttca agaacggaaa 3828361 atcaggcgca tcggttcaac aaaggataca ccgattgacg tacgtattat tgccacgatg 3828421 aatgaagacc caattgatgc aattgcaggc gaacgaatgc ggaaggactt gtattacagg 3828481 ctgagtgtcg tcacactgat catcccgccg cttcgggaac gaaaagaaga cattttgctt 3828541 ctcgcgtcgg agttcatcca gaaaaacaac catctgttcc aaatgaatgt tgaacacatc 3828601 agcgatgacg tgaagcaatt tttcctttct tatgactggc cgggaaatat tcgcgagctt 3828661 gagcatatga tcgaaggcgc aatgaatttc atgacggacg agcaaacgat tacggcttcc 3828721 catctgccct atcaataccg catgaaaatc aagccggctg acatcccaga gccggaaaca 3828781 ccaagacacc agccagccgc ggacttaaaa gaaaaaatgg aaagcttcga aaaatatgtg 3828841 atagagaacg tgttaagaaa acacggccat aacatctcga aagctgctca ggagcttggc 3828901 atcagcagac aaagcctcca atatcggctg aagaaatttt ctcactcgtc taacgaataa 3828961 tccggagcag gaagcctgat cagaaaaaca gtgcctctgc cgatttcact tttcacttca 3829021 atcgtcccat tgtgattgtc gataatcgat ttcgttatgg caaggcctaa tcccgaacct 3829081 ccatatttcc gggagcggga tgggtctgcc ttgtaaaacc ggtcaaacac taaaaaacgt 3829141 cacttcttat gcattgaaga aagaaaatgg cacctatgtg tatcacagcc agcaaccaca 3829201 cggtacaaac cattaaagtc catgcaaata acggaagtat ttgcagctaa ctgccatttg 3829261 ctgtttcacg tgtaacatcc atcttgtatt tttcttcata ttcgatatat cctttttcaa 3829321 ctgaacgggc gtgacccctg ttcagttttt tttgcatatc aaaacagcct ggcaacgatg 3829381 ccagactgct tttattaact gcctaattgg tctgcggagg acagcttgat atcaacagat 3829441 ttttcttttc cgccgcgata aaacttcacc ttcacccggt caccgacttt tttctgataa 3829501 agccgttttc gcaggtcaac aatatcattt actttgtatc cgtcaaattc cgtgatgaca 3829561 tccagttcct tcagccccgc ttttccggca ggtgaaaagg cgtctacacc catcacaacc 3829621 gctccattgg tgacgttctt aggaagcttt aatgtttcat cccaatgata gcttgcgatg 3829681 tcacttagcg atttcatctc aatgccaagg aacgggcgtt tgacctttcc gtatctctct 3829741 aaatcctcta tcacagggat cacgagctta gacggaatgg acaggccaat cccttcaacc 3829801 gctgactcgg caattttcat tgaattgatg ccaatgacct tcccatccat atttaacaaa 3829861 gcgccgccgc tgttcccagg gttaatggcc gcatctgttt gcaggacttc agcgttccag 3829921 tcaggctgtc catcaccgtt tgaatctact gggatcgccc tctccgtacc cgagatgacg 3829981 ccttgtgtga cagagcctgc aaactcaagg cctaacgggt tcccgatcgc aataaccggc 3830041 tccccagact tcactttatc tgaatttccg aaatcagcga ctgctttaat cttatcgctt 3830101 ttcacccgta aaacggcaag gtccatcagc tggtcgctgc cgacaagatc agctgataca 3830161 cgtgagccgt ctttcaagct gatttcaatt tgggaagcgc cttcgatgac atgatggttg 3830221 gtcacgacat aagcggaatg gtcatttttc ttatagatga cgccagagcc gctcccagcc 3830281 tcgccgctct ctccccaaat atctgatttt tggatgttca caacaccgac aacggcgggc 3830341 gacatattgc tgacaatctt ggtgacggca ttgttgacac tgacattcac cgtcctgatt 3830401 gattcccggc cattgttgtt ttgctgctga tctaaggcgc ctgtatccag cccttcattt 3830461 gaaaggtacg gcatgataaa cgccattaat acggcaccga caatcacgcc aatcagactc 3830521 gaaagaaaat atcctttttt gcttctcttt ggctgttcag gagtagtatg ttcttcctca 3830581 cgttcgtaat ccaccatatt ccatcctttc caagaacgtt aatatggtta tattgtgggt 3830641 tagaaactcc tagaatagtc atgatttaca tagaaaaatt atacagcgca aagcggagtg 3830701 gccttcttcg gatcggtgtc gtataagtca aatgtctcac ccgtcacaaa tcctttagaa 3830761 gccaatgtct gctgcacaga cattcttgcc agctccttca tgttgttgtc ctggctcaaa 3830821 tgcgccaggt aaatacgaga cgtctcatcg ccaatgacat ccgtcatcgc caaggcagca 3830881 tcttcatttg acacgtgccc gacgtcactt aaaatccgcc gcttaatgct ccatgggtat 3830941 cttcccattt gcagcatacc gacatcgtga ttgctttcaa acacaaatac attcgctgaa 3831001 cggataatgc ctttcatccg gtcgctgaca tatcccgtat ctgtcattaa cgcgagcttt 3831061 cggccgctat aatggaatac ataaaacatc ggttccgccg catcgtggga aacgccaaac 3831121 gattcaacat caagtccgcc gaacgacttc accgtctcca ttggaaatac aaacttttga 3831181 tcggtgtcaa ttttgccgat ttgattctcc atcgctttcc aagtcttctc attcgcatag 3831241 atcggaagct tgtactttct ggcgacgaca ccaaggccct taatatggtc actatgctca 3831301 tgcgtcacaa aaatgccgtc tacatcatcc agcttacgcc cgatctgcgc catcagccca 3831361 tccatggctt ttccgctcaa accggcgtcc actaaaaatg cgtgatcctc tgtttcgagg 3831421 taaaacgcat ttcccgtact cccgctcgca agtacgctaa attgcaagct catgtttgtc 3831481 tcactccatt attttcattg atctgtatct aaaatcgtac tctccaaagc attcacagta 3831541 aaatactctt gtactgtctt tttctcaccg ttcacttttt tctcgtactc gaccgtaatt 3831601 ctccataccg gcgccagcac ctgcgtactt gtcagcggat attgtgctac atagccgaat 3831661 ttacagctct tcacagtgct gtattctttt aattgatttt gatagtacaa tagctcaacc 3831721 gcatccattt cagtaattaa gctttctttc tggatttgct tgaaggtctc aagcgtagtc 3831781 tggtcgtatg acacaacctc gtttttaccg tttaagtgca gcaccacttg cccgatcata 3831841 ttagagggat tgtcggtctt ttggtaaata taatgacctt cgtacgtttg gaagaaaata 3831901 atttctttct tcgatttatc aaccttccaa agcttatatt tttcgccatc ttgaattttc 3831961 gaagaaacaa gtgcctgagc atcgtcctcg atatccttct ttgatagtgc gattggattt 3832021 gcaaacttca ttttcaggct cgttacttta tgatcatcac taggcatgtc catcaaaggc 3832081 ttttgatcct tcagcgcctc aatttcctcc ttggagaaag acttttgatt tgccgtgatc 3832141 cgatagcctt ctgttgcttc cttattcaag ccttcatacg tgatatgatc ggccttcatg 3832201 tcatgctcga catcattttt aatgacttca tattctttgc cggtagcctg ccatttttga 3832261 aaaaactgat agcctaagaa aatatctaaa atgaggaagg caacgatgaa gattgatttt 3832321 gtcttattcc actccactgt tagccccctc cttcctcaat aaatcctttg taatcggcac 3832381 aatttttcca tttactttca tcgcccaaac cggttccagt tcaacgagag gatcatcgtt 3832441 ggttgatgtt gataccaatt gataagcaag gaagatctga tcaattttgt ccgtatcata 3832501 agcggtttgt ttcgaaagca gcatcttcac ttcgctgccg cccatgagct ctgtttcact 3832561 tgttttaatc ggattcgttc cgagactgta attcggccgc ttatagctga gaatatcatc 3832621 attcgcccat tgcaccgtaa tcgccgatgt cgccccgaaa ggtttggcgg tgctgttaat 3832681 gaccgggatc tgatccataa aaatatagaa gctcaactgc tggctgtcat tgatattgaa 3832741 aaattgatag tgatccgtcc agcttccggt atcctcaagg tatttttggc tctttttgat 3832801 taattcacct gtttgatagg atgtgctctg caccaaattg cgctgctgaa attgcacctg 3832861 tctctggctt agattcacat ctaaccggct gatcccatct gtcagcacat ttctgttgtt 3832921 gtaattcgaa tcttctctta caatgctcgg atcactaaac aaagcctgct taaaggtatt 3832981 tgttttaatc gattctgtga caaattcttt tttgtccatc gtaagcggtt tgttcggcag 3833041 caagaactct ttctttgagc caatggagaa caaactgaac gccggcatat ttgattgcct 3833101 gtttttcaag tcgttcataa tgttccggta gtttgctgat tcaaccgtca cttcaagaat 3833161 gagctgcttg ctgtatgaca ccaaatagat tttcttgttc gcttttgttt cattgaacgg 3833221 gatcagaata tggtcaaacg aactgtattc aaacgactga ttagaccatt taaacagcgt 3833281 ttggaaaata tcaatcggga tcgtatcgct gaattgcaag tcaagcttgg cttcagaacc 3833341 gcctattcca taaaaccagc ttttgaatcc agccttgtca tactgatccg aaatatcttt 3833401 aattcctttc acatcccaat gcggcaagtc agaccaaatt tcttcataga gggcattgtc 3833461 atccactttg taatgagcgc cgtcatcatg gataaacatg tcccttggcc ttaccgtttc 3833521 agacagcttt tgggtggttt tttcgatttt atgtttcaca cgaacagtag actctgttga 3833581 ggatgagcct tcagaaaagt ttggctggaa cgtccatatc ccccatgtaa aaacaagact 3833641 gatgacgacg agtaccgtaa gtaatatcgt ttttatattt tcacgcttca tcccaatcat 3833701 cctcttgttc ctctttatat ggaagagtaa atgtaatcgt cgtgcctttt ccttctatgc 3833761 tgtccgccca aatatctcca ccgtgcgcct gtaccatttc cttggcaatc gccaatccca 3833821 gaccggtgcc gccaagcttt ctcgttctcg ctttatccac cctgtagaag cggtcaaaga 3833881 ctttttcgac atcttttttc ggaatgccga tcccttcatc cttcacgctg atatagagaa 3833941 gttcttcctc ttcattgaca tcaatcgaga acgtgacatg tccgccttcc ggtgaatatt 3834001 ttaaagcgtt agaaataata ttatcgagca cctgcgttat tttatcctgg tcaatctcga 3834061 catacagatc tctgtccggc agattgcgga taaactccac atgctgctct tttgtcattt 3834121 caaaacggtc aataataagt gacataaacc ggacaatctg aatccattcc cggttaaatt 3834181 gataatcttt actgtcaaat ttcgacagct gaagcagatc attgacaagc cggatcatac 3834241 gctctgtttc attttgcgtc accattaaga agcgcggagc aatgtcttta ttttcccacg 3834301 cgccttcagc taacgcttct aaatagctgc gcattgtcgt aagcggcgtc cgcagctcat 3834361 gtgatacatt cgcaacgaat tctctgcgtt cctgatccat tttctcttgt tcggttacat 3834421 cgtaaatgac agcgattaaa ccatcaattt tgccgtgttc cctttgaatc acagagaaat 3834481 tcacgcgaag caccgttaat tcatcatcgc gctcaatttc aagcagcata gaatcctgct 3834541 gttccactaa atcttcaaaa gtataattct cttgaagccc cagcaaactc gtaatcggca 3834601 tttctaaggc tgtttcacgt gaaacgttca acagttccag cgccgggctg tttaagagaa 3834661 taatcgctcc gtttcggttt gtggcgataa cgccgtctgt catataagca atgacagagg 3834721 ctagctttct gcgttctcct tcagtcatcg cctgggcatc ttcaagctct ctcgttaagt 3834781 ggttaaacgt tgtggccagc tgcccaattt catcatgtcc atacttttta accttcctcg 3834841 agaaattccc tttcgcaagc tccatcgcct gctttcgcat atctgaaagc gggtgggtaa 3834901 tggttcttgc cagaaaaata ccgagaagag ccgtcaaaac aagtgccaaa cctgtgccgg 3834961 acgccagtat cgtgttgatc gtcttcattt gattaaagac atcttccata ctcgcgacaa 3835021 cgtagatcgc gcccacaacc tcttggtttt cagtcatgac gggcttcgcg gaaataagaa 3835081 ctctgatttt gcttttcggg tcataatatt ttcttaaata cgactgtttg gtagaaaaga 3835141 ttcttttgaa aatcagatcg gtcgtttgtt tcccagccac ttcctcaccg tacggctttg 3835201 aagaaccgac cacttcatag cttttatcta caaagctaat ttcccgaacc tcatcacttt 3835261 tcgtgaagtc attcaaaata cggctgacgt catcctttat gacggtactg tcgttatcgc 3835321 tcttatattc ttgttcgata taataagaaa ggttgtcgat tcgctgattc agcgattgtt 3835381 cataagagct gatcagcgac ttctctacct gattgacaaa atacacacca atgatttgca 3835441 tggcaatgat aatcaaaagc acataaatca aggtaatctt aaattggatc gaccgaaaaa 3835501 aaccaacctt attcatatgg gcattagtcc tgttctgggt ttctcaagta ataacctaca 3835561 ccacggcgtg tgacgatcca atttggatgg ctcgggttgt cctcgatttt ttcacgaagc 3835621 cggcggactg ttacgtcaac cgttctgaca tcgccgaagt aatcatagcc ccaaacggtt 3835681 tgaagcaaat gttcacgggt catcacttgt ccgatatgtt ttgctaaata atgaagcaat 3835741 tcgaactcac gatgagtcaa ttcgattgtt tcgtctcgtt ttgatacaac gtacgcgtca 3835801 gggaagatga cgagagagcc gatatgaatc tcgttagagg aaggctcttc ctccgcaggc 3835861 gctgttgtca gctggcggcg caggttcgct tttacacgcg ccaagagctc gcgtgtgctg 3835921 aatggttttg tgacatagtc atcagcaccg atttcaagcc cgataacctt gtcaatttct 3835981 gaatccttag ccgtcagcat aatgattggc atatcgtatt tctttctgac ttcgcggcat 3836041 acttcaacgc cgtctttatt tgggagcata atatctaaaa gaattaaatc aggctgaagc 3836101 tcttctacca tttcaacggc ttcgtttccg tcgtgggcac agtgcacttc atagccttct 3836161 tttcttaagt taaattccaa tatatctgca atcggttttt catcatctac tacaaggatc 3836221 tttttatcca tcattttgat tttcctcctg ccgaatgact tcatttcatc tatataacat 3836281 tcgtttcatc acttatggcc catgtaaaga atgggtcctt gtctattata acggtttaag 3836341 gtcaaaagat aaaaaaaata aaggtttaga aaaaaaacac atgtttcacc tttatcgcca 3836401 gttgtttatc tattgtcatg ctggtcaact ttttttaaaa aagataactt tattgaaacc 3836461 tcccctcacc ggagtgcgtc tttatcaatg acgtcttctt ctttgaaccg gccgcagggc 3836521 cggttctccc tttttcttct attataacac tcctcatgtt tgcctttttc ctaaaagaaa 3836581 aaacgcacct acgattgcag atgcgtttgg taagtggctc gggacggaat cgaaccgccg 3836641 acacacggat tttcagtccg ttgctctacc aactgagcta ccgagccaaa tgttttattt 3836701 ttctctacta agtaaagtaa aatggcggtc cggacgggac tcgaacccgc gacctcctgc 3836761 gtgacaggca ggcattctaa ccaactgaac taccggacct tacagtaatt gcccggagag 3836821 ctgtcgtgtc agctctcaca gacaaataag gaatttagca ataacgctaa agtaaatcaa 3836881 tgacccgtac gggattcgaa cccgtgttac cgccgtgaaa gggcggtgtc ttaaccgctt 3836941 gaccaacggg ccttcacgaa atggtgagcc atgaaggact cgaaccttcg accctctgat 3837001 taaaagtcag atgctctacc aactgagcta atggctctta aagatgtcgg aatttctata 3837061 gagcaaacga cttaaatcta gttctcatct tgtactctat tgaagcagtt tccgtaacaa 3837121 cgagatttat aatatcacga acaaatagaa gtggcaataa cttttttggt tttttttcat 3837181 atttttttct cagaccaact tatatgcggc tttcaaacaa aaacaagccc cttaaatagg 3837241 ggcttgcaga catattctat ttagttcgca cggtacacac tgcgaaggac atttgtttgt 3837301 gagcggtctg gaccgacaga gaaaatagaa agcggaatgc ctgtcagctg agacacacgc 3837361 tcaagataat ggcgcgcatt ttccggaagc tcgctcaagc tcttcgcacc tgtaatatcc 3837421 tcagtccagc ccggcatttc ttcatatacc ggctcacatt cagcaagtgc cttaagactt 3837481 gctgggaatt cttcaatgat ttcgcctttg tagcggtacg ccacacagat tttcaacgtt 3837541 tcaattcctg ctaggacgtc aattgagttc agagaaagat ctgtaattcc gctcacacgg 3837601 cgggcgtggc ggacaacaac gctgtcaaac cagccgacac ggcgcgggcg gcctgttgtt 3837661 gttccatatt cgcgtccgac ttcacggatt tgatcgccga tttcatcttt cagctcagtc 3837721 ggaaaaggac cgtcgccgac acgagtcgta tatgcttttg atacaccgac aacgtgcttg 3837781 attttggtcg ggccgacacc agaaccgatc gtgacaccgc cggcaaccgg gttagatgac 3837841 gtaacaaacg ggtatgttcc ttggtcgata tcgagcataa ccccttgtgc gccttcaaat 3837901 aatacacggc gcccttcatc aagagcatcg tttaagacaa cagatgtatc gcaaacatac 3837961 tttttaatct gctgtccgta ctcataatat tcgtctaaga tatcctcaag tttaaaccct 3838021 tctgtctcgt acattttctc gagaagacgg tttttttctt caagattgcg ctcaagcttt 3838081 tccgcaaacg cgtcacggtc taacagatcc gcgatgcgaa ttccgatgcg ggctgcttta 3838141 tccatgtaag cagggccgat tccttttttc gttgtgccga tcttgttagc ccctttacgc 3838201 tcttcttcca cttcatccaa tttcaaatga tacggcagaa tgacgtgagc tctgttgctg 3838261 attctcaggt tatctgtact cacgttgcgc tcatgaagat acgcaagctc tgtgactaat 3838321 gctttcggat ctacaaccat tccgtttccg attacacacg ttttatcctt atagaaaatt 3838381 ccagacggga ttaagtgaag cttatatgtg attccgtcaa acttgattgt atgccctgcg 3838441 ttatttccgc cttgataacg ggcgatcact tctgcatttt ctgataggaa atctgtaatt 3838501 ttaccttttc cttcatcgcc ccattgcgta cctactacaa ctactgaaga catgtccgtg 3838561 cacctccgtt aacctttcaa aacgattcta ttcaaacaaa tcaagtttat cagtgaagaa 3838621 acagaaagtc aattgtaaat ccgaacatta atttattgta aatctatatt cgttcgcttc 3838681 cattcgtttt ataagcgttt tctcactgct ttgtcataaa aagcttgcga aactttcatc 3838741 ctttagcata agaaagaatc acttgcctga tatccctttt gaattcataa aaacgatccg 3838801 ccagccgtcc gggtcctcta tcgtcacgcc cccattgctc cagtacgggt tctctgattc 3838861 gacctcttga tagcccatgt gctttagctt tgaagtgatc gctgccagtt caactgcatt 3838921 cggcacataa aaaacaagaa ggctgtcggg atggggaacg ggggcagtgc ttcccccttc 3838981 atactgggtg aattccaaat gataatcggc atgaggaagg ccgaacatga caccgtcata 3839041 cccgttatgc tgtgaaaatt ctcctattcg tttcaaacac agtccctctt cgtaaaaacg 3839101 aataatctca tcaagctggc ccgtaggacg cgcaattcgg atttgtgctg cttgaaaaga 3839161 cgaaaaacgt tttcccatat tgttaccatc tcctttttgc accattttat taaaacgctt 3839221 tcaatttttc atccgctgag cgaacgtcat ttcttccatc tttcgaatga aaaaaacccc 3839281 aagagcagct cttggggctt atgcgccggg cggaacgcct gcgtcatcaa aacgccgttc 3839341 caggttgacg aatttgttgt attcttttac gaacgcaaga gacacggttc ctaccgggcc 3839401 gttacgctgt ttggcgataa taatttcgat aatattttta ttctcggttt ctttgtcata 3839461 gtagtcatca cgataaagga acgcgacaat atccgcgtcc tgctcgatac ttcctgattc 3839521 ccggatatca gacatcatcg gacgtttatc ctgacgctgc tcaacacccc tggaaagctg 3839581 agaaagcgcg ataacaggga cttgcagctc cctcgcaatc gacttcagtt cacgggaaat 3839641 ttcagatact tcctgctgac ggttgtcctt tgaacgaccg cttccctgaa tcaattgcag 3839701 gtaatcgatc aaaatcatgc ccagcccgct ttcctgcttc aagcggcggc acttggcacg 3839761 gatttcactc actcgaatac ccggtgtatc atcgatgtaa atcccgctgt tcgataggct 3839821 tcccattgcc atcgtcagct tgccccaatc ctcttcggtc aggttacctg tacggagatt 3839881 ctgggcattg atatttccct cggcacagag catacgcata acgagctgct cggcacccat 3839941 ctcaagactg aaaatcgcta cgctctcatc ggtcttcgtc gccacgtttt gtgcgatgtt 3840001 cagggcaaag gctgttttcc ctactgaagg acgggcagcc acaatgatca agtcgttgcg 3840061 ctggaaaccc gcagtcatcc ggtcaagctc cgtaaaccct gttggaattc ccgtgatatc 3840121 accttttcga ttgtgaagct gttcgatatt atcataggtc tggacaagga cgtccttaat 3840181 attttggaag gcactcgtgt ttttgcgctg tgccacttcc ataatcgttt tttccgcttc 3840241 actgagtaaa tcctcgacct catcctcacg ggtatacccg tcttgagcaa tcgttgtcgc 3840301 agttctgatt aatcggcgaa gaatcgattt ttcctcaacg attttcgcgt aatattctat 3840361 gttagccgct gtcggcaccg agtttgcgat atctgtcaaa tatgaaatac cgcctacttc 3840421 ttccagcagg tctgtgttcg caagctctga tgtaactgtc accagatcaa ccggttcacc 3840481 tcggtcaccg agcaccagca tcgcattata gattttttgg tgggacattc tatagaaatc 3840541 atctggaatc aatacttctg aagccagtgt taaagcagac ggctgtaaaa aaatagcgcc 3840601 taacacggct tgttcggctt ctatattttg cggaggaagc cggtcattca gaaggtctgt 3840661 catgctaagc accgtcctct cattaaaaaa tctccaacct ccattctacc atttctacag 3840721 aaaaaaaata gaaaaattgt ctgtttcctg tttttttcag ttagcagatt ggatcgtttc 3840781 ggacagtaac aaggcgggaa aaatgcaata aaacataagg gaggaatgaa agatgataaa 3840841 gaaatatgcg attacaccta atgttgatgc ggacggctgg tttattgagg tggagaatgt 3840901 agcgccgaca gctttgtata cgtctaaaga cgccgctatt gaaaaggcca aacaggtggc 3840961 taaggaaaac agtccgtcta agcttgtaat ttatgaccag tttaaaaatg tggaagaaga 3841021 acactcattt taatgaatga aagccttcgc tgcagcgagg gttttttagc ggttatcggt 3841081 ttatttcatc cattggatgc ctatgtgcat catcaaatct gccgcttttt gatacagatc 3841141 ccactccccg atcgaagcaa atttccccat cagctcctga agctttaacc tcattgctat 3841201 atattcttcg aaagtgacag ctttttcagt gtctatttgg tgttccttca gcatttgttt 3841261 taataaggat aacggtgcgt gcataagaac cctccttacc tcttttataa cggtcatttt 3841321 ccgattgctc tattcctttg tgacatcttc ttacatttca catctgattc ttgtacaatg 3841381 gacagaagag aggagggatc ttttgtgaga cctttgcaaa tttctgccga aactgcacaa 3841441 aagcttgcag agtccttgaa tctgccgctt gaacagatca tgcatatgcc tcagcatatt 3841501 ctgcttgcca aaatggctga actgcaaaaa gaggacaaat catagccttc attcacatac 3841561 ttgcttacct gtttcgggat aatatcatgt atatgttaga aaagaggagt aactgctttg 3841621 ccacatccac ataataaaaa aatccaatca ttttggctga tcaccggcat tatctttatc 3841681 gcctttaact tacggcccgc gatcacttca gtcggtccgg tcatcagctc tatccgggca 3841741 gagctgcaca tgtccaatgg ggcagccggt tttttgaccg cactgccgct gctttcgttt 3841801 gcagttcttt ctccgcttgc acctaagctt ggacagcgcc tcggtaatga gcgaacttta 3841861 tggctaggtc tcgtgatact gctgatcggt gttctgactc gttctaccgg ctatactgcc 3841921 gctttgtttt tcggaacagc acttatcggc gtcgggattg cgattggtaa cgtacttttg 3841981 ccaagcttaa tcaaacataa ataccctgaa aagccaggga tcatgatcag cctgtatacg 3842041 acatcaatga atatattcgc agctttagca tcgggtgtca gcgttccttt agcgacccag 3842101 atgaatggcg gatggaaaca agcctttctc ttatggggcg ggctggcttt acttgcattg 3842161 ctaatctgga tacctcagct gcgccatcga gatacggcaa accagacaat gaagctgcaa 3842221 tccagttcca tttgggcttc caaaatggca tggtatgtca ccatctttat gggcctgcaa 3842281 tcgtttttat tttacagcag catcgcttgg tttcctgaaa ttctccgttc acacgggatt 3842341 gatacggcaa cagccggatg gatggtatca ctcatgcaat ttgcgagtct gccttccact 3842401 tttctgacgc cagttttagc tgaccgtgtg aaacagcagc gcggtatcgt tgcggcgctg 3842461 gcctcagttt atctgatcgg cctttgcgga ttattagcgg gcggaagcca tacattgctt 3842521 gccatctgga tgatcattat cggtatcgga caaggctcca gcattagtct ggcccttact 3842581 ttgattggtc tccgcagtga aaatgcccaa caggccgctg cgctgtcagg catgtctcag 3842641 tcattcggct acctgctggc agcagtcggg ccaatctttg tcggctatct ctttgaccag 3842701 acgcattctt ggacgatgcc gattgtgctt ctcattgctg ccctgatcgt aatgggagca 3842761 gccggacagg gagccggacg agatcgatac attttccagt cagaaaaaca aagaaattca 3842821 gcataaagcg gggaagatat ctccgctttt ttctttgaat atttatggtt tattcataag 3842881 tttttcatat ttgtttttta caatgagaca ccataaagag gtgaaaaacg atgaaaacca 3842941 aacgattcga cgcagccctt attcttattt tgctagcagc agcttttttg aatacgtatc 3843001 acatttggca ggatgataca gcaaaccagt actatttggc ggctgtaaaa agcatgacgc 3843061 aaagcttcca taactttttt tatgcgtcat ttgacccttc tggatttgtg acagtagata 3843121 agcctcctgt cgtgttatgg attcaaacga ttttcgcact gattttcggt gttcacacgt 3843181 ggagtgtcat cattccccag gctcttgccg gagttggatc tgtcttcctt ctctacagaa 3843241 tggttaagcc gacttttgga gttggagcgg cccgcattgc cgcacttgtc atggcactga 3843301 cccctatcgc agtagctgtc agccggacaa acaatatcga cagcatgctt gtttttacct 3843361 tattgctcgg ttcaacttgt ctgcttaggg cagtaaaaca aggcaagctg gtttggctgc 3843421 tgacggcatt tgccctgatt gggctcgcct ttaatatgaa gatgatgcaa gcgtttatgg 3843481 tattgcctgc atttgtgtta ttctacctga ttgcatctcg ggtttctctg aagaaaaaaa 3843541 tcgggtccct gcttctgtct cttgtccttc tgacaggcct ttcactctca tgggcgattg 3843601 cagtggattc agcctcttcc tcaagccggc cttatgtagg aagcagccag actaactcag 3843661 tgctagaact ggcctttggc tacaacggca cagagcgtct gtttgggcaa actacgggcc 3843721 ttgcaaaggg tgatatgaat gctgctggcg gagggaacat gcagaatcaa gacaacatgc 3843781 aagcgccaaa tggcaacggt tcatcttttt ctcagaacgg taatcaatca ttcggaaacc 3843841 attcacaggc gcctcagccg cctaacggac aaaccggcgc tctcaatgga ggcggaggca 3843901 cacctcccac aggtggcaac ggacctggaa atggagggcc tggcggcgga ggcggaaaaa 3843961 gcgtgaatat gttcggcacc ggtgatcctg gaccgcttcg tctcttccaa tcagcacttt 3844021 ccggccaaat cagctggatg cttccattct cattgatcgg attactgggc gcaatcatca 3844081 gctggtaccg tgatcgccgc ggacatgctg ctaaaatgaa agaaacgcta ttctgggcgg 3844141 cttggcttgt tcccgtggct ggtttcttca gcatcgcagg attcttccac cagtattatt 3844201 tgattatgct ggcaccgccg attgccgccc tttctggtat cggatggtat acgatgcacc 3844261 gcttatacaa aaataataaa gactggtcca gctatcttct gccggcagcc gtcttgatca 3844321 cagccgtgtt tcaggtgtat attctgagcg cttatacaag ccaaatcggc agtgtatgga 3844381 tgtatgtcct ggggctctta ggactgggca tcacccttgc acttctgatg cttaaacgca 3844441 gccatccgtt cagtaagctg ctgaccatca tcagcttgtg cgttctgctt ctcacaccag 3844501 tttactggtc agcaacgccg cttctatacg gtggcaacag cgtccttcct gaatccggcc 3844561 cgcagctcaa aggctcagca aacggcggga acatgttctc ttcagaggtc gacagcgggc 3844621 tcctgtccta tctgagaaaa cacaataccg gcgaagagta tttatttgct actttgacaa 3844681 ccgtaacagc tgcgccatac atcatttacg aaaatgaatc tgttatggca atgggcgggt 3844741 ttaacggcac ggatcccatt ctgactgtgt cggaactgaa aaaactgatc aaagaaggca 3844801 aagtgaaata cttccttctg tcagaaaaca actcaggcaa cagcgaactt gtttcctgga 3844861 ttaagaaaaa cggaaaagaa ataacatctg acgagtacag cggttcctcc agcagcacaa 3844921 acagcgtgca gggaatgcga agaggacctg gcggagaaag ccagcaaact ctttatctcg 3844981 tggaataaaa aaagaggctt ggatgaatcc aagcctcttt tctattaagc ttcttctttt 3845041 acatgtacct ttaacacagc ctgcacttca ggatgcagct tcacaggcac gtttgtatat 3845101 cctaatgcac gaatgccgtc cggcagttca agcttccgct tatctacttt aatgttatgg 3845161 tctttttgga gctgttcagt gatttgcttg cttgtcactg aaccaaataa acggccgccc 3845221 tcacctgatt ttgcgctaag ctcaacagtc agtttttcta atgtctcttt caagctctta 3845281 gcctgctcaa gctcagcaat ggcttctttt ttctctttct gcttttgtcc gtttaacgcg 3845341 ctgatgtttg acgcgttcgc ttcaaccgcg aggccttttt taattagaaa gttatgcgca 3845401 taaccgtctg ctacgttttt gacttcgcct ttttttcctt ttccttttac atcttgtaag 3845461 aaaataacct tcatctctgt acgcctccct caaaatactc atctatggcg tgcttcagcc 3845521 gttccagcgc ttcagaaact gaaatgccgg acaactgagt cgccgcattt gttaaatgcc 3845581 ctccgccttc cagggcctcc atgatgatct gaacatttac ctcgccaagc gaccgagcac 3845641 tgatacaaac cgtttgttca tcccgtctcg ccaccgcaaa tgaagcctca acctcactca 3845701 tcgatagcag cgaatcggca gcctgcgcaa tcagcacttg atcgaagtat tcctcttcat 3845761 tttcaggaag agaagcaatc gcaatgttat ctttatagag gaccgtatgc tggatcagct 3845821 tcgcccgttt aatataggaa tcaacggttt ctttcagaaa cttctgcacc agcaccgtgt 3845881 cggcgccttt tgcccttaaa taagaagccg catcgaaagt ccgcgagccc gtgcggagag 3845941 aaaagctctt tgtatccact attataccag ctaatagggc tgttgcttca atcatattga 3846001 tttttaagcg cttcggctga tattcaagca gctctgtcac caattccgct gtggaagaag 3846061 cgtatggttc catataaacg agcagcggat ctctgataaa ctcctcacct cttcggtgat 3846121 ggtcgatgac cacgatatgt tcaattttat tgaccagccg ttcctccatg acgagtgacg 3846181 gcttatgtgt atcaacgatc acaagcagtg tgtcatcatt ggaaatctcc attgcttctt 3846241 caggcgtaat aaatcttgac cacagttctt catatttttt gatttcccca atcaaacgct 3846301 gcacacttga tccgatttgg tttgggtcaa tcacgataaa accatctttg ttatttgcct 3846361 gagccacctt taaaatcccg atcgctgcgc cgatagaatc catgtcgggg aatttatgcc 3846421 ccatgataat cacattgctg ctttcggtga cgatttcctt taaggcgtga gaaatcacgc 3846481 gggcccgcac ccttgttcgt ttctccattg ggtttgtttt accgccgtaa aacttcacct 3846541 tgccgtttgg cagcttaatg gctacctggt ctccgccgcg tcccagtgct aagtccaagc 3846601 tggattgcgc caaatcgcca agttctttca gggaagagac tgaagccccg acaccgacgc 3846661 ttaacgtcag cgctacaccg tcaaacgagg ttttttcccg cacttcatca agaatcgaaa 3846721 acttcgaatt ttcgagttca gttaagatat gttcattaag tacagcaata aagcgttctg 3846781 aagacgtcct tttcaagaag atcccgtact cctgcgccca agcgttcagc aaagatgtca 3846841 cctggctgtt catcgtgctt ctcgtctggt catccaatcc ttgtgtcaca tcatcatagt 3846901 tatcaaggaa aatatatgcc aggacggttc tttcgttttc atatagcttt tcaatctgga 3846961 tttgttctgt tacatcaaag aaatataaga gacgctcatc ccgtttgatg acaaccctaa 3847021 acttgcggtc attcaatgta accgtttccg attccacctc ttgtttgata agcggcacta 3847081 ccgattcaca agtatcgtaa agtgatctcc ccactaaagt gctttcatta aaacaagagg 3847141 aaagaaacgg atttgcccat tctatataat attggtcatt aaaaagcatg attccaatcg 3847201 gcatttccat caatgcctct tcaccgactt ttttcaacct gtaggacaac gtagaaatat 3847261 aagcatcaat ctcttgtcga ataagagaat cagcacgctt aataaaaaac aaaataactg 3847321 ccagcagcag cacttcgacg gttcctaata tccagttaaa ataaaagctg atgaggattg 3847381 taataattga cagagcaatc aatgcataga tgggataccg aaacagcggt ttttcataaa 3847441 agcttggcat ttctatcact ccccaccatg tgagtaaaac tcatgttcac ttcaccttat 3847501 tccttatatg aaagcccata tctaaaacgc ctaaaatgcg aatggccgcc atgaagaccg 3847561 gatgcacaaa cccaagtatg acagcaatca cagccgcagc ctttggatat tgtttcttat 3847621 ggcaatagaa aaagataaat gataaacctt ggatgaaaat cagaaacccg agtataaact 3847681 ccccatttaa agcgatagag tacagcattt ggcctttttc taaaggcaaa aatgaaagca 3847741 tgacaataat caaatacagt actacaacac tttgcggaaa cttcaactct ctaaaaggct 3847801 ttagattagg aatatcgggg gagaatcgcc ttaagagcgg cttagcgata aggtaactga 3847861 ggaaagaaaa aataactcct accatcacaa tagctgttgg aaaaagatat tgaacgatac 3847921 ccaattgttc ttccatcagt tttaattgct tctcaaactg cccagcattg cccgactgct 3847981 tcgctacagt ttctacaata tcaagagatt gccggtattg tgtcattgcc tcatcaatga 3848041 tattgatacc caaaaactga atgcttatca caaaatagaa gacaatacta agcatataaa 3848101 taagagcgcc cgaaataatg gcgtgcccgg gctctttcct tttgaaaaaa tgtcccatgg 3848161 caatgccggc gcaagctgac ataaaagcta caataagccc gttaaaggac ccgacaataa 3848221 aaacaaccgg aagactgaca gcgcccatcc atatccctag cttcaatcca tgtctgatcg 3848281 tatacaagat cattggcagc ggcagtgcaa ataacagaat tgttccaatc acaggaacat 3848341 aaacgaccag aagcgtaatg atcgcaaaca gactgattaa aatagcacct tccattaaag 3848401 ctctcgtttg tttcacttag tcacctcgta tcatcctgaa catacgaata gaaaagagca 3848461 gcataaacga ctgctctttt gttcatcgct gcaacatgct ttgcaccgaa tgtttttata 3848521 tcatctctaa attttacttt tatattttaa cataagtcca aatcgcaagt aaaatgacgc 3848581 taatgtttca tgtgaaacat gaaaaaggaa aagacattct ttgaaaagaa tgcccatcac 3848641 aattaatgtt tatcatccat aaagccagaa gattccttgt ttttcttttt cgtttttctg 3848701 acatacataa aaattaagat caccagtaaa agggttgttg cttgcagaac gccgctgcta 3848761 aacaagaaaa agttctttat catgtcccac attgtgtttc acctctttgt gcatgttctc 3848821 aacccgtatc ctatataagg tgaatttccc tttttaaaaa cttcaaaaca tcatgaacaa 3848881 cattgagcgt tgggcatatg ctgatatgga atctgatcga taaaggagaa ttttcacatg 3848941 gatgaacgca gaacattggc ttggcatgaa acattagaaa tgcacgagct ggttgctttt 3849001 caatcaaacg gactcattaa actgaagaaa atgataagag aagtaaaaga ccctcagctc 3849061 agacagcttt ataacgtgtc tattcagggt gttgagcaaa atttgagaga gcttcttccg 3849121 ttctttccac aggctccgca cagagaggat gaggaagaag aacgcgcaga taacccattt 3849181 tacagcggtg acctgctcgg ttttgccaaa acatctgtcc gcagctatgc catcgcaatt 3849241 acagaaacag caacacctca attaagaaac gtactggtca aacagctgaa tgctgccatc 3849301 cagctgcacg cccaagttta tcgatacatg tatcagcatg gatattatcc gtcttacaac 3849361 ctttctgaac tgttgaaaaa cgatgtcaga aacgccaaca gagccatttc aatgaaataa 3849421 aacaagcagc aaaggagttc cctttgctgc tatttctgct gatccttcac taagccgttc 3849481 gaacgataag attccagcac gtctctgttg gattctcccc attctttcat ttgcaaaaca 3849541 atcggttcaa gcgtgcgccc aaattccgtc agagagtact ctaccttggg cggcacctgg 3849601 tgataaacct cacggtgcac gatgccgtcc gcttccagct ccctcagctg gagagtaagc 3849661 attctttgag taatactcgg gcagattcgc cgaaactcat taaatcgttt cttgccatct 3849721 atcatgtgat aaaaaagaat tcctttccac tttccgccaa tgacatctag agtgaattca 3849781 actggacagc cttctttgtt cgggtatata ttcttttttt cactcattct tgaccctcca 3849841 atagtacctt ttttgatact acattacatt ttgcaactaa tctacccagt attttacaca 3849901 ccttttctcc ttagctcaaa gaaaatgctt cttattcaca tcaattttta agggtttgca 3849961 tgattacacc tgcagcaaga cgtgttaaac tatataaaga ttacactact taaaaaagga 3850021 taggagctat catggaaaag atacttattt tcggacacca aaacccagat acagatacga 3850081 tttgttctgc gattgcttat gctgatttga aaaacaaact cggcttcaat gctgagcctg 3850141 tccgcctcgg acaagtcaac ggcgaaacac aatacgcgct tgactatttc aaacaagaaa 3850201 gcccgcgtct tgttgaaaca gctgcaaacg aagtaaacgg cgttatcctg gttgaccata 3850261 acgaacgcca gcaaagcatc aaagacattg aagaggttca ggttttagag gttatcgacc 3850321 atcaccgcat cgctaacttt gaaacagctg agccgcttta ctatcgtgct gagcctgtag 3850381 gctgtacggc taccatctta aacaaaatgt acaaagagaa taacgtgaaa atcgagaaag 3850441 aaattgccgg ccttatgctg tctgcgatca tttctgattc cctgttattt aaatctccaa 3850501 cttgcacgga ccaagacgta gcagcagcaa aagagcttgc ggagatcgct ggagtagatg 3850561 ctgaagaata cggcttgaac atgttgaaag caggcgctga tctaagcaaa aaaacagtgg 3850621 aagagctcat ttctcttgat gcgaaagaat ttacactcgg cagcaagaaa gtcgaaatcg 3850681 cacaagtaaa cacagtggac attgaagatg taaaaaaacg ccaagctgaa ttagaagctg 3850741 tgatctcaaa agttgtggct gagaagaatc ttgatctgtt ccttctcgtt atcacagata 3850801 tcttagaaaa tgattcactt gctcttgcaa tcggtaacga agcagcgaaa gtggaaaaag 3850861 cgttcaacgt tacattagaa aacaacacag ccctcttaaa aggcgttgtt tcccgtaaaa 3850921 aacaagtcgt tcctgtctta acagacgcaa tggctgaata agcaaaaagc atcccgcgtc 3850981 gggatgcttt ttcttattca cccagcttct caatttgtcc catcacatca gtaatttgct 3851041 ttgcgttttg gaccaggtct gactgctcca attctttaag cgataccttg ccttcctcgg 3851101 cttgtttcaa cacatcttca gcgcttttct gcaaggtttc gttatgctcc tgaatggttc 3851161 gatgaatctc cgctgcggca tcaggcggcg ttaattcatt aaaatcagcg gcagccttct 3851221 gaatcgactc aagctgcgct tcaagttttt ctttcgcctc ggtgtcattt acagctttct 3851281 cagccaattc aggcgcttcc tctgcaaatg tcttcacctt ctccacataa ccagctgctt 3851341 cactcgtata gttcaatccg tcgttcacct gatcaagcat gccgcatccg cctgcactca 3851401 aaagtcccac tccggcaagt actgtcaaaa tgatcttcat cttcagcccc ctcatcgttt 3851461 ctttttcatt ttttctttta agatcggaat caatttctct ttcgctaacg gcagcccttt 3851521 cctcaccaat tcacgcttca gccacttttt cagcttagac attctgatgc tcctctccct 3851581 ttttgataaa aatgaaaaaa ctccaccaat ttggtgaagt tcctgaaaca aaaagacctt 3851641 caccaaatca gatttggcaa aggtctcgct aacaatgaga ttgccagcaa agccgaggac 3851701 accttgtccc gtaatgacga ctttactgtg aaagctactc ccctttggag tgttcatttt 3851761 tattactttc attctaaagc accgatctgt tccagtcaaa ttcctgccgt ttatataaaa 3851821 gcgcgctgtg gtatttaaaa tttgaatggt ttttctatca ggagatcatg ctatgacaga 3851881 ggaggttttc atcatgagtc aagagcgcgt gaaacggcct gggcatacca gatggtacat 3851941 atcttcgtta cttagcggca ttattattct taattatttt gaccgagtgg ccatctcggt 3852001 agcggcccct gcgatacaag attcgtttca ccttactgca actgaactcg gcatcgtgtt 3852061 ttccatttac acctattcct atacactgat gcagctgcct gtcggaagtt tgctggaccg 3852121 ttttggggtc gcatgggtca cgagggttgg aatgacaata tggagctttt taacgatcct 3852181 tcttgctttt ttgcaaggaa aattgctgtt gtatctgttc cggtttctca ttgggctgac 3852241 gagcgcctct gcgttccctg ctgcctctaa agcaaccgct ctctggtttc ctccaagtga 3852301 gcggggattg gcaaactcac tgttcgattc ggccgccaag ttttcaaatg taatcggcgc 3852361 gccattggtc gcctttcttg tcacaacatt tgactggcgt gtcgcttttt tgacgattgg 3852421 atgcatcaat gtgctgttta cgatcttttt ctggcagtat tatgaacagc ctgaacggca 3852481 caaacgcatt tctaaaagtg aactaaacta tattcaaaaa cacaatgcca ttacaacaga 3852541 gcaaatccct tacaaaacgg gcccgctttt aaaaaagctt ttcaccaatc gaaaagtatg 3852601 gggcttaatg atcggattta cagggtacgg gtatacattc aacctgctgc tcacctggct 3852661 tccgactttc tttaaacata catacggtat ggatctcatg tcgtccggtt tatttacggc 3852721 agtgccgtgg ctgatctcaa ccatttccgg aattgccgtc ggcggctggc tcgtcgatta 3852781 ttttattaag aaaggctatc ctaataccaa ggtgtaccga accgtaatca tagtcggaat 3852841 gagctttggc tttttctttt taggatccat tctgacgaac aatattaccg tagccattat 3852901 ttgcatttcc atcggactcg ccggaatttc cgcaaccgct ccggtcggct ggtccatctc 3852961 cgcagaactc gcgccgatcg gttccgtatc catgctgagc tccatggtga atctcgcaaa 3853021 caacctgttc ggaggcatta ttgctgcgtc actgacaggg tatttgtttg atgtgacagg 3853081 ctcctttacc ctcagctttc tggtagctgg ttttgtgctg ttgctgggat tggtttttta 3853141 tgtgtttgta ttaggggatg taaaacgaat taaactatag aacatgaaaa agagagctgc 3853201 cagttggcag ctctcccttt acatcaaaga atcggcccgt ccccatttac cttctcctcg 3853261 tcctgttcct ctatatcaag ccccgaagct agcatttcct gctctatctg ttcgagcacc 3853321 tgctcgtttt ttccttgaag accaccttca taatgaaaag catcctgtgt gccgttttcc 3853381 tctattgtcg ctaaaatatc gtggatatca ttatggtctc ctgaaatgga gccgaatccc 3853441 tggttttgtt ttttataatt cacaaaaccg ctggggaggt tgtttccgag gtttacacat 3853501 gatgcgctcc gagtagtaat tcatcagtgt atcaaaatct tcattttgga ttgccacatc 3853561 acatgcagag atgatgtctt tcaattgctg ttccaaatga attcccctaa tcatcatgat 3853621 tggatatatt atacaatgtt tgacacgtag ggatcctttt catttttgtt tttacggttt 3853681 cgctggtcca tttccgcaga gctggcgccg atcggttccg tatccatgct gagctccatg 3853741 gtaaatctgg caaacaacct gttcgaaggc attattgcgg cttcattgac ggggtatttt 3853801 gtttgatgtg acaaggctcc tttacgctca gctttctggt agccagtttt gttctgctgc 3853861 ttggattggt tttttacgtg tttgtcttag gggatgtaaa acgaattaag cgggaataaa 3853921 gagtgcttgt agagaaaacg ttgttctttc tacaagcttt ttagttttgt gctgtttttc 3853981 aagatattca gctgtcataa aaagaaaatg agctcccaca taccggctag gtatgtggcg 3854041 ttcttcttca tgttctggca tgcagctgtg aggaggattt gtttgctcac cccctgaacc 3854101 tgcgatagct aagcccgtgc agttgttttg aacctacaaa gcttcgttct attttttctt 3854161 ttcttttttt agagatttcc tgaaatagaa aagcaatctt ttctaacctt ttctttatgg 3854221 ttttgccata cataccgagt aacgactttc tggcgtttcg ttgattttgt gtaatattct 3854281 caaacatatt tcaggatttg atttatatga ccgatagtct ttgcgatcaa ttgttgagta 3854341 cgtaagtgta tgctgattca acaaatgtat ctgtattgtt cactttataa tgaaatttcc 3854401 attttggaag caaacccctg actgggtgat aacgtctatg tgcgatggca ccaaaaactt 3854461 ggaggtcaaa tagtccttta gagatgagag ttgttaagta gccggaatct agagcgacgg 3854521 cttctacttg aaaatcaaat catgcaattt agtgatccaa tcggtcaagg tagggcttgg 3854581 aacagaatca tggacttttc tggagttgca aactattaat cgtcctcatt aaatttataa 3854641 taaaaatatt ctcaattgag caaatcgccc accctttttc ctttataaca taaaatccaa 3854701 tactatcaat aaaattcttt acaggttatt acagttaaga tataatatag ttaatctttt 3854761 acgtaaaagg aggtttttat tacttgtgtt gaagttttaa ataggagtaa ctccatctcc 3854821 ccattacggt cttcatttaa tttcatcctg agttttattt agttagatat aaaaacgaaa 3854881 atttcacatt atttttaact aaccgatagt ataaaatata tattgaaagg attgtaaaat 3854941 tatgaataaa ttcctgaaga gcaatttccg tttccttctt gcggctgctt taggcatatc 3855001 attacttgct agtagtaatt ttataaaagc cagcaatgat aactataaat tccatttact 3855061 tgtaccttat ggctatggta atgcctattc aaatgatgca tttagacaga ccactcatac 3855121 agataatcct tggaaagtaa atttacagaa atcggcagaa ggtaaaggta caatcatgac 3855181 attttggttg attaacacag ggaatagtaa aattccaaaa gcttctaaaa tacataacgt 3855241 aaaacaagga agcggagctc attattatca tgcaaatagc cagggaagcc atacatatgt 3855301 agccttagca gttgaaaaca acaattacag tgcaagttct tatggtatag atggtgtatg 3855361 ggatgaagaa acttggtaaa caagaacctt ctaaaaacgt tggcaccttt tagccacgcg 3855421 aaaaaattta gaatgataat ctttttataa gattatcatt tttatttatt ctattaagaa 3855481 ttgagtgaga acatggaaag tcatatttat cgcattatca aaaataaatt aactataata 3855541 atatttacta taatcatatt aattccttgt gttgatatat cactattgtt aatgactaac 3855601 acagaatacc atcctgcata tgcgtttttc ctttctggca cttccgtagg gcatgcttca 3855661 caaatgatcc tattatggtt tcttccgctt tattttttgt tactatgtgc tgacgattct 3855721 atacaagatt ataaaacagg atatcattac attcttataa gcaaagttgg cagaaaaaaa 3855781 tattgtttgg aaaaaatatt tacctctttt atcatttcat ttttgacaat gtttttgtca 3855841 ctaatattaa actttttatt ggttcaggtt ttctttttta aaggtacatt taaaaatgac 3855901 ttagaccaaa ttaaattccc tgataacagc ctttatactt ttagtatggc ccatccttat 3855961 atagcaattg tgttattttc tattatttgt tgtattatgt ctggatttgt tggagcactt 3856021 ggttcaagcc tcagtttact ttttcgtgat aagaagtatg cctacccagc aagttttttt 3856081 atttggttcg tacttatact aaaaaacaaa tcattaatgt ttttattcca accgtttaca 3856141 gaatacggtt ataatgtact tctccctatc ctatgtttgt ctatctttat ttttctaata 3856201 ataatttcta gtattgtttt atatgaggca aaatacaatg aaaattaaaa gactactatt 3856261 aattttatgt ttactactat ttttagttac tttatggttc aaccagaacc acacttatct 3856321 tggaaagaat tctatcgcgt cattactata tatgaataat agtacattcg gatatagttc 3856381 aatatttgca tataccttgt tttatattgt cccgtttctt atgttactta gtaacttttt 3856441 tcattcagaa aacccctaca aagtaatgag gatggttaag cgtaaaaatt actacaagtc 3856501 taaaattatg gagattgggt ttgtttcttt acttttttct tcaatacata ctgttattaa 3856561 tattacgtgt acacatattt tctttagtaa aaacttgttg gtcgaagcaa actttttatc 3856621 aatttgttta ttaaacatga ttagtttagt gtttttctac ttatcagtag gtattatgtt 3856681 tagacttaca tacgatctgt ttaattcagt agcattagca atttttattg tgtatataat 3856741 tttagatagc ttgtatttcg gcgttaaatt attacttcct aatggatatt gggaaccctt 3856801 tagagacttg gctatattca caaatatgct caatagatat tggtcaactt caaatcttat 3856861 aatagtttat attagacaga taataatagt ttttattttt tatttagttg gatcttcaat 3856921 ttttttgaat aaggattata aaaaatgagg attaaaggct ttttcataac tttagttgcg 3856981 ataatatttc aggcgtcatt atcgagttat aataataata aaaatgtctt tcctttttta 3857041 gatggcatac caataagcac ctcgggtcat tatgagtatc aaaatatttt attgtggttt 3857101 gtacctattg tttccctaag tttttgtttc tctgggagta ttagagatac atacatttcg 3857161 tatgagcaat taaagttagt aagagaacat agtagagtta aatgggtaac atctcaattc 3857221 ttaataatta cagttgtact tttaatcttt actttatctc agattgctat attttatatt 3857281 tattcacttg tatctcttca taaccttgat attaattccg ttatcaataa aagatttgtt 3857341 atgatgacac tcatgtatta tctaacctta cttaacttat ttagttttca attatttatg 3857401 gagctttatt ataaatctca aatagcacaa ttaaatataa gcgtttatat tattttttcg 3857461 ttaattttag caaagaagtt agtgcaatta aattctccga aagttattca ctacttttta 3857521 attccaaact acagtaatgg attaagaact gggttaagct attattccca atctggaact 3857581 gctattattg aaccattatt aggtttgttt attataatca ttttacagat ttcaatagtt 3857641 atattatctg tcttaaagtt caaaaaaata gatatgctaa aaagtgaggg cttacaatga 3857701 ttgaggtatt aaacctaaca aaaaaaatta aaaagactac agttttagat aatatctctt 3857761 atacatttga aaaaggaaca atttatggac tatttgggag taatggttct ggaaagacca 3857821 tgctacttcg tgcattatcc gggttaatag tccctactga agggagtata actattaaag 3857881 gtgaacaatt acataaagat atctcttttc ctaaaagtgt aggattaatt atagaaaata 3857941 tgcagttact tcctcagtat gatgctttta ctaaccttaa aattttgtca aaaattaaaa 3858001 agatcgcatc agataatgat atattagatt ctattagtag agttggtttg gaaaatttta 3858061 atagtgtaaa ggttagtaaa ttctcgttag gaatgaaaca acgattaaat attgcacagg 3858121 ctatttttga aaaacctgat atattgctac ttgatgaacc aacaaatgcg attgatgaaa 3858181 aaggagttgc atttgttcat gacattcttt tacaagagaa aaaaagggga gctaccatta 3858241 ttattactag tcatcacaag gaagatatta tatctttatg tgacattgca ttagaaatga 3858301 atcatggacg tctagaaact tcagaaaaag taatatataa gaaagatagt tagtttaaac 3858361 tggctatttc ttatccaatg atagactgca gacaagttca actgctgtaa tgctagaaaa 3858421 tccaatgaaa tgctgataat tgcgaagaga tatgatcagt cagaaaacaa atcttaaaaa 3858481 gaaaaagtaa attcatcaat atttctaata aacctggcaa acaacctgtt cggaggcatt 3858541 atagctactt cactgacggg atatttattt gatgtgacag gctccttacg ctcagctttc 3858601 tggtgccggt tttgtgttgt tgctgggatt ggttttttat gtgtttgtat taggggatgt 3858661 aaaacgaatt aaactggaat aaagagtgct tgctgaaaag cactcttttt ctgcatcgaa 3858721 agaatactta agataagtca ctcccaaaaa tcgtaacagt ctgacggtta aacataaacc 3858781 tctgcccgtt ccattttaat acggtttgaa catatcccaa tgagtcggcg ttataccttc 3858841 ccgctatccg ctggtacgcc aataattcgt atacgccgtc tctgtcaaaa tcaaccggat 3858901 acaagcccga taaaggattc acccatcctt ctatcggcat ttttaacaca ccttggctgt 3858961 tataaatctc attcaaatat tccctgccct tgtaagtaag gtcgaggata tacgtttcgt 3859021 tttgctgatg actgataacg ctcgctttat attgattttg atacctcaca ctgtacttta 3859081 attcatcatt caatacatct gaattgaaaa ttcgccggaa ctgcctgttt agataggcaa 3859141 acacatatgc ataaatagca ccgccgcttc cccctgtgtc cattactact gccacatcct 3859201 caatcttgtc gcctgtcata tcccccagaa aaagtgacgg attgtatccc atattgtttt 3859261 gaagctgaat ccgctgctcc tgatgggttc tgccatcacg gatcaccaat gtgatatttc 3859321 tccataacgg gctgccgggc atttgatttc cagttagaaa gacctcgtca ataacgccgt 3859381 ctcccgttac atcgccgcgg gtagatacaa tgattgcacg tgaggagaca ggctgccgaa 3859441 atacgtatgg atgttgaaca agtcctctgc cttcataaaa ccaataagga gccattctga 3859501 tgtcatacac attcaattgt gtcaccttcc ctaatcagct gaatgaatca ttatatgcag 3859561 gaatggcaca tcaaagacat atcttacaca ccaattaaat ccgtaccata tgaattatca 3859621 attacacaaa gccactcgcc ttgcgcattc tttttaaata cataggtcgc ccttctttcc 3859681 atcgcatact cggagtcctt tttatccgaa tcaagcagtg tctgagaaag aacgagtacc 3859741 gtgtcacctg cttccaacag gatcattttc ccttgtgtcg ggacaatatg atgattgaaa 3859801 tagttcgcaa tcgtgataaa cgcttttttg atttcttcct tgcctcgcgc gatcatgccc 3859861 ggcttcacaa ctaaaacggc atcttccgaa taataattca tcagtgtatc aaaatcttca 3859921 ttttggattg ccaaatcaca cgcagagatg atgtctttca attgctgttc caaatgaatt 3859981 cccccaatca tcatgattgg atatattata catcgctaga ccactgaaac cttgaaaaca 3860041 aaatgaaaag tatccttttt tcctatataa tcaaatagat atatttaaca aagtacccaa 3860101 gtgaaggggt gaacattatt gtctgcggaa gtaacgttac atgacaatat acattatgat 3860161 ttaagtgcgg attgccagca ctgttttggc ctgtgctgtg tcgccttgcc ttatgcgaag 3860221 tcggcagatt ttgcttttga taaagacggg ggcacgcctt gccgcaactt acaatcaaac 3860281 tatcaatgtt ctatacataa agatctcaga gaaaaaggat ttcgaggctg ctctgcatat 3860341 gaatgctttg gcgccggcca aaaagtatcc caaatcactt atgagggaaa ggattggcga 3860401 aacagccccg aaacggccaa ccagatgttt gacgtttttc ctatcatgca gcagctgcac 3860461 gaaatgctct ggtatttaca tgaagctctt tctatagata tagccaagcc gattcattct 3860521 gaactgagaa ccactttcga aaaaatagaa aggctcacca gactcagcaa agaacgcttg 3860581 ctgacactgc aggtggacga gcatcgagct gaggtcaatg aatggctgtt aaaaacaagt 3860641 gaactggtgc gtgcccaagc ccgccatcca aaactcccga aaaaggtcag ccggggaagt 3860701 gtcctgatcg gcgcgaaact gaaagggctt gatctgcgag gagcaaatct aagaggggcg 3860761 ctgctcatag ccgccgatct gagaaatgcc gatttgagaa tgacagactt tatcggtgca 3860821 gatatgagag acgctgatct cagcggcgcc gacctgaccg ggagcatctt tttgacacag 3860881 gcacaggtga acgccgccaa cggcgattcg aatacaaagc tgccgctgtc tgtacgaacc 3860941 cctgcccatt ggaaataaaa aaggacccgc taacggtcct tttttactga tcaattcaat 3861001 cctttttcgt tcctcttatc cggcattttc acacttcttg ccaagtatcc cgacagccat 3861061 aacgcaacca gcagcatgaa ggtgatcata ccgacgacgc ccagccagtg aaaaccagac 3861121 cagaatagcc ctccgattgt tccgaaaaca cttgaaccgg cgtaataaaa gaacaaatac 3861181 agcgatgaag cctgtgcttt gttgtgaagg gctctcctgc ccacccagct gctggcaact 3861241 gaatgccctc cgaaaaaacc gaatgtaaag agggcaatcc ccagaatttt cactgccagc 3861301 atattgttta tcgtaaataa cgcacctgca atgacgatga aaatattcat caccaatatt 3861361 ttcggatagc cataccgatc aaccattctt ccaatgaaag acgagctgaa aatgcctaca 3861421 atcatcacaa taaagatcca gctggaaaat gctttattaa gcgaatacgg cgggcccaac 3861481 agcacataca caatgtaatt aaacaaggca acattgcttc caagcagcaa aaaaccaatg 3861541 agaaacaagc tgaatagttt acggtccctc aagtggccga tcagagacat tcccaatttc 3861601 ccgagcttca attttcttgg cgtaaaatgc ctggatggcg gcaaatttat aaaaaatata 3861661 acactagcaa tcaaactaat gacaccaatt gtccccatcg ccatatgcca attcaagtac 3861721 tcgctcagga gcccggaaac gatccttccg aaaacggcgc cgattgcatt tccgctgata 3861781 tatagcccca tcgctgatcc aagacttccg ggttcaattt cttccccaag ataagccatc 3861841 gcaatcgacg gaaggcctgc gagcgcaacg ccttgaatgg ttctcaatac gagcagtgta 3861901 tgaaagctcg gactaaaggc cgatgccaga cagagaaccg atgcggccag catggaaata 3861961 cccataatag gcttgcgtcc ccacacctcg gataatgaac caaagacaag catgctcaca 3862021 gctaacagca ttgtggtaac agataaagaa agactcgccg cagtaggcgt tacatgaaat 3862081 tcccgcgtga attcctccat gagcggctgt acgcaatata gaatcgcaaa tgtattgaaa 3862141 cccgcagcga agaaagcaaa cgtaattttt cgaaaaaccg gtgtgccttt tcgaatgtat 3862201 gtcatcggga ctttatcggt ccctcatcat gttgtggagc actgccattc ataaacaatc 3862261 atcctttatt tcttacgaat tcaaacatcc tcgagtctgt ttatattatt atcttagcac 3862321 cgttgatata tgttgtataa tgcatataaa atatcctttt catgcttata tgtaataagg 3862381 agagatgata attggaatgg gaacaacttg aatattttca aacactggcc cggatgcagc 3862441 acgtcacgaa agccgcaaaa agcctctcca tcacacagcc tgcactttca cgctctatcg 3862501 ccaggctgga aaatcatttg ggcgtcccgc tatttgacag gcaaggacga tccatcagct 3862561 taaatcaata cggacacatt tttttacgac gggttcaggc gatgatgaag gagtataccg 3862621 aaggaaaaga agaaatccaa gccttattaa agccagacca aggcgtagtc tctctcggtt 3862681 ttttacatac attaggcacc acgctcgtgc ccgatctcat cggctccttt cagcaggaat 3862741 accccaacat ttccttccag ctgaagcaaa accactctta ttggctgctt gaacgattaa 3862801 aatccggaga tctggacctc tgtctcctcg cttcgattaa gcctgaaaat ccgatccaat 3862861 ggatcaagct gtggagtgaa gaactctttg tatttgtgcc aaatgatcac ccattagcca 3862921 gtcgcgaaag cattaccctg aatgagattg ccggggagcg ttttatttta ttgaaaaagg 3862981 gctatgcgct tcggatgacg gtcgatgagc tgtttgagaa ggccaatata cagccgaaca 3863041 ttatgtttga aggagaagaa gcaactactg ccgcaggttt tgtggcagcc ggtctgggca 3863101 tatctattct cccagacctg aaaggcttag accaaagcaa aatcaccaaa atccgcgtca 3863161 gctggccgga atgtcagcgt gtcataggaa ttgcctggat aaaaggcagg tttttatcac 3863221 cggttgctga gacctttaaa caatatgtga tcagccattt ttctgagtag gaaggattca 3863281 agcatgaatg tcaaaaaaat cacgtcagaa caggatttac atacagcgtt tgaaatcaga 3863341 aaggcagtat ttgtagagga acaaggctgt cccatttcgg atgaattcga tgagttcgat 3863401 acactccacg gtgactgcca gcacatcctg gcttatcatc agaatgtacc tgttggcact 3863461 gcacgtgtcc gtatcgttgg ccacacgggg aaactggaac gaatctgcat tctgaagtct 3863521 taccgcaaat tcggtttggg aaaagtgatc gtcgatgcat tagaacgtat tgtaaaagaa 3863581 caaggcattt ctgccttcaa actgcacggc cagacacagg cggcaggctt ttatgaaaag 3863641 ctcggctatc ggactgcatc agaagaattt atgctggacg gcattccgca tgtgctgatg 3863701 acaaaacaag acgattctgc gctatagatt gttcacaaat ttgtcactta tgagcatgaa 3863761 cggttcattg gtatactaat caccgattat ggagagaagg aatgattgta tgccagcaaa 3863821 taaaaaagaa ggccttatat ttggcgtgat gatgtgcttt ggaatggttt gcgtcatgtc 3863881 gatttacaat gccatcatca accgagccat ctacgatttt tcactgatga ccgtttttga 3863941 aatggtcatc ggttttatga tcgccctcct gttagattta ctgttagtgg gccccctcgc 3864001 caagaagatt gcattccgca tgccgttcga caagactaaa aaaatttatg tcatccttgc 3864061 catgtcaact tgtatggtga ttggcatggt actttgtatg tctgtgttcg gtttagtgac 3864121 agcggttcta gcaaatgggc tgaacgggga cagcctcttc agtgcttatc ttatgattgt 3864181 gttgaaaaat ttcatcctgg cctatccgtt gcaattactg attatgggcc cattagtcag 3864241 aggagttttc atgaaatttg taaaaccaaa gctcacagcc gcaatttaaa tagaaaagga 3864301 gtgagcctga cactcactcc ttttgctcat gaatcgaatg taaaacaagc tccgcaaaag 3864361 cctctgcggc aggcagctgc cattttttct ttttgggtgt gagtaaatcg gatcgagggc 3864421 ttcaccatgc tggagatttt tcagcttatg tttttcactt ccattaatcc ctatacctta 3864481 ccacatagtt tttatacaat tcttcgttat aaaggatttc ttcgccatgt gaagagcaaa 3864541 tgagcgttgg tttgatttga tctatgattg agccgctgtc gatgttctca tttatatcaa 3864601 cactgaatct tcttataggt gggtgtaaat cctccttact tgtgataaaa aggtcgcccg 3864661 tcaatagcgt acgatcgatt ttatgataat acacaacatg ccccggcgaa tggccaggtg 3864721 ttaaatagta tttcagaggc agatgagcaa gcgtttgctc cgtcagcggc tgtacaatat 3864781 gggctacccc tgtgttctcc acttcatttt tgttcggata tggctcttcc ccattgatgt 3864841 actttagttc tttctggtgc gcaaaaatcg gaatatcaaa tctctctaac cattttgatg 3864901 cacccccgat atgatcactg tggccatggg taagcaaaat ggcttttgga ttgccgatcg 3864961 ctaacgctgc cctaatttga gcatcagcaa aacgttctat tcccgtatca acaatataaa 3865021 catcatcacc atctttgata aaccaggtat gaaccggaat acgaagaggc acatcaagct 3865081 caaattcaca ttgaaagaca tgttctgata gttgtctcaa attcacgcaa accatctcct 3865141 gtggaaattt tttgatagtt ttaaagaaaa cagaagtgaa cggactattt tcacccacgc 3865201 tcgagctgac tggattcttg agaggaaacg ccgattttcg ccagcatcag ctcaacttgt 3865261 taacgttgtc cattaataat cccttttgtt ccccttcttc acatattccc aatcacgttc 3865321 tatattcttc ctcactctat gaaggagtgc agaaatggtt tccttttcct ctgaagtaaa 3865381 accggacaag gccacttccg tggaatgttc tccttctctt cttaacaatg gatatacctt 3865441 tttccctttc tcagtcggga acagtttttt tattttttta ttttgctcat ccggcagttt 3865501 ttgaataaat ccctgcattt ccagcttctt aatggcccgc gcggccgttg tccggtccac 3865561 ttttatcatt tccgccaatt tttcttgaat aattcccgga ttttcgtata tacgcacgag 3865621 atagagatac tgccctcttg ttaagtctaa atctttaaat tcgatgttgc ttatggaatc 3865681 caacgctctt gctatcatgc cgatctcacg caaaatatca ttcattccta aaacccctca 3865741 cgtatttttg ttgcaattac aacaaaaatg ttttaacctt actattataa gaccacatgc 3865801 gtgctgtaca gtccagacta atatcagaaa aggattgatt cataatgaat ataaaaagaa 3865861 taacaactga agctgattta catgaagctt taaagattag aagaggcgtt ttcattgagg 3865921 agcaacatgt gtctgaagcc gatgagttcg atgaatttga tacgcttcag gaacaatgcc 3865981 agcatatctt ggtatatcat gagaatcagc ctgtcggcac cggacgcgcg cgcatcgttg 3866041 gccatacagc aaagctggaa agaatctgca tcctaaaacc ttaccgtaag tacggattgg 3866101 ggaagatcat cgtaagcggg ttagaggaaa tcatgaaaga aaaaggactg acttcatata 3866161 agctgcatgg tcaaacacaa gcggcaggct tttatcaaaa actgggctac cagatttctt 3866221 cacaggaatt tatggaggac ggcatccctc acgtcttgat gacaaaagaa atatcgcgga 3866281 atataacatg aaatatatgt attacggaat aggcatactc atattaagtt tgggcatttc 3866341 cttaaccata caatcaggac tgggcacatc acccttcgat gcccttttgg ttggtctgtc 3866401 aaaaaaaatc ggtcttaccg taggaagctg ggaggtcctt atttctgtga tcctcttaat 3866461 ctgcaacgct atattaacga gaaaaaaacc tattttgctg ggcttgatta cagcattcat 3866521 tactggaata ggcattgacc tatggttgtt tgttgtaaaa aacaccatct atctaaactc 3866581 gttgttaagc aaactgattt gttttggaat tggtttggtg ctcatcggtc ttggaacagc 3866641 catctatctt cagacgaaat tcgcatcaac accgatcgat catttaacac ttattatccg 3866701 agatctctcc aaaagaacaa tattgttttc aaggacattg gtatacgctc ttttcttagt 3866761 attagccatc atctttaaag gccctatcgg catcggaact cttttaacgg tttgtttggg 3866821 aggaatgctc cttcacgttt ttatgcctat tgtggaaaga catttcttat caaagaatag 3866881 aagaggttat taagaaacct cttctcgatc caaaaaacga aacgcaaaac aagccccgtt 3866941 tcgttgtcaa ttctttatct ctggtactgt tgaggtttta taatcaatta aaatttatag 3867001 taccaaaaaa tcgcaatttc atttgctgtt ggaaagttgg aataaagcat cgtatcaacc 3867061 gcacctatta taaagtgatg tttggcataa aaatgacaag ctgaaatatt aatatcttgg 3867121 gtttcaagca taagaccaca aaaatgattc tcctttgccc actcaatcgc tttatgtaat 3867181 aatgctgttc caacaccttt ttttctatag tcttttgcca cggcaatgtc ctctattagt 3867241 gcatacccat tccagttaga acggatctta atccggccaa tgcagttgtt ttcaagataa 3867301 tataaaaaag ccgctttccc ctcttcttca acataactaa catccatgtc atcatcttca 3867361 tattgtttaa aataaggttt agaaaatcgt tcctcagtat atgtccaaac accgttttca 3867421 aaagcaggta tcattctccc aaaaacaacg aaaggttcgt ttggtttatt gaaatctttc 3867481 atattcaaat gagtcatttt catgatcata tcaatctccg ccaatcgaga taatatttag 3867541 taaactcgtt tcgatactat tcaacaacag cttccaaaag tgtactcttt aagagaacag 3867601 cattagataa ggcatccatt accttatata tttcactatc ttaatgaggt atttcaacag 3867661 aggcttgtgg tacagtaaaa aggaatagaa acaagagaaa agaagatgaa cctatgccca 3867721 ctaacaataa actcaatgag aaatatcata cttccttcaa ctcgcccaca accctgttga 3867781 ctagtatccg tggagagagg aagctttgac acagcttctg ccattgatga catctctatt 3867841 gaagtatcca aaggacaacc aaggatcgct ctttgacttt ttcaagaaga aagtagagtg 3867901 aataaaggag tgattgagta tgttaacaag agaagatatc tttaaacacg tcaaagaaaa 3867961 atacggtaca tcgcctgatt acccgtggga gaaataccca aactatgctt ctttgagaca 3868021 tacatcaaac aaaaaatggt acggtcttat catgaatgtt ctcccagaaa aattaggctt 3868081 ggatggtcat ggcgaaatag atattctaaa tctaaaatgt ccccctgaaa taagtgatcg 3868141 cttaagaaac ggggaaaata tcttacccgg atatcatatg gataaggaac attggatttc 3868201 aattgtttta gaacggacag atccagaagg cgaaatctat aacttaatcg agcagagctt 3868261 tcatttaacc aagtgaagat aaagagtgtt cctgctaatc aagctgcgaa gagtagtggg 3868321 cactttcatt ttaggatact gttcttcact ctgtccacaa acgcaactta gttcatctgg 3868381 tgcgagagtg ggagaagaat ttcaaccaac ttcttatgta aaaggatgaa tagttatgac 3868441 aaataactta aaacagagaa gaatcatttt agatttagca gttactttag atggttttat 3868501 tgaagggaaa aatggagaag ttgattggtg tattatggac cctgatatgg ggtttactga 3868561 ttttttaaat caaattgata ctattttata tggtagaaaa agcttcgatt tatggggaca 3868621 atacattcca aaaaatgaag accctgatac agaaaaggaa ctttggaaat tggttcatag 3868681 taaaaagaaa tatgtttttt ccagaacaca aaatgagatt gataatcaag ccatatttat 3868741 aaatgataat attcttgaag aagtaaataa attgaagaaa aatcctggta aagacatctg 3868801 gctatatggt ggagcgagtc tcattacaac ttttataaat ttggggcttg ttgatgaatt 3868861 tagattatct attcaccctg ttgttttggg agaaggaaaa ccgttgttta ttgatgtaaa 3868921 acagaggata aatttaaaaa tggtgaatac aagaacattt tcctctggcg ttgtgcaaat 3868981 cgtttatcat tggaatggct aacattgtaa agtaacactc gacagtaatc cttcttattg 3869041 aactaaaggg gaatccataa ataatgggtt ccccttaata tactatggaa ttatcaatat 3869101 caaattttct gtaataaaag aggattgaaa aggacgatgt ctcctcaatt aacatcatta 3869161 agcattatag tatattttct tctccctctt ttaagtaatc ggctaagttt tgtatttata 3869221 aaaaaacgaa agaaggtgat ccaatgccta ctaacaataa acccaataga ttaatcgctg 3869281 agaaatctac ttattttact tcaacatgct cataaccctg tggactggtt cccttgggga 3869341 gaagaagcat atgaaaaagc gaaacgcgaa aacaagcctg ttctcgtatc tattgggtat 3869401 agctaacgat ggctaatcta aagaacatgc tattgatgcc atgtttattc attttacaaa 3869461 aaaggatcaa ccttgaatta ctttcacaag attgatcctt tcactcattt agccatgtct 3869521 ccgcgaacgt ttatatacat tcaagattac tagccaacaa ataacaatga ttcctgcaaa 3869581 aagtatgagc atattgctat acaaataggt agagtgatca acgtcaatag gcagcagcct 3869641 atgatctagg aagccgatag ataataaacc gcctacaatc gcaatacccg ttccctctga 3869701 taaaaagctc gtgaaattaa gcaaactcat tccagcgccc gcttcctttt ctttcaaact 3869761 gctagacaca actgtagata taactgtttt tgtgaaagat agccccccaa aaacaaaaat 3869821 tactataatt gtcatgatcc atggtgctgc atctataaaa aaggcagcga ttaaaaagcc 3869881 ggaagaaagc aatgcacttc caatagttag tacatacaag gaacctttcc gatcaacaag 3869941 caatccccca atgtaaccaa agatgatgac actcattgtt ccggggaaaa taatgccgct 3870001 tccaattgct gcagtactta aatggtgaac atctttcatc atgtaaggaa ccatagagac 3870061 aaatcctgct actgtaccaa atattagtcc tccgcaaagg gttccaatca caaaaaagac 3870121 gtttttccct aattcagggt caacaaaagg gtcctgagct ttcctaatgt gttgcacaaa 3870181 tatgaagaaa gcaaggatac tgatgatcag aaaagaaaat ctataagatg ttgtaaacag 3870241 cataaaaaat acgatacctg cagacatcaa tataatccct gccatatcaa tgtgtcctct 3870301 tattctctct tcctttttca acaattttat aaggaatgga acggtgataa ttgttgcagt 3870361 tggaataagc agcaaatacg accaatggat ataatgagca accattccgc caatagctgg 3870421 cccaacacct tctcccattg ctaccaggga cccgatcagg ccaaatgctt tccccctgtt 3870481 ctcttttgga atatagcgcg caacgacaac catcacaaga gctgggaatg cggctgcacc 3870541 aattccttga ataaatcggg ctagaatgag aataggaaag aaagagtgtc caacaaatcc 3870601 aatgatcgac cctaagccat ttaccataat cccaaataga agcagatttt tgatgcccag 3870661 ctggtctgat agctttccat atagagctgt tccaatggag aaggttaaca taaaggctgt 3870721 attcacccag tttgcacttg ctggcagttt attaaactcg ttggcaatat caggtaatga 3870781 gacgttcaga accatttcat ttaatacgct gaaaaatgat agaacacaaa gccaaatcaa 3870841 aacttgattg tgccgtaaag ttgactgtga ataagacgta ttcacaattt cccctccatt 3870901 aatgagggca gacgcagttt atagggtcat tgatacgctt ccctctttta attgtaccct 3870961 gttcatttta ttgcacttca taataactcc ccctacattt gattgatatg atcttattat 3871021 atatagacta aggattaaac ttttactttt tttataaaaa tttgaccaga ttgcgaaaca 3871081 aggaaaaacg ttattcgcat ttatctcaag tggcaaaatg aaacattagt ttatattttc 3871141 acatcacaat tatcgataag cagtcagtta ttgtatttgt ttaggataac tgtggtaacc 3871201 tgaatataac caacttagga agaaggtgat cccatgccaa ataaaagtaa acccaataga 3871261 ttaatcgctg aaaagtctcc ttatttactc caacacgccc acaaccctgt ggactggttc 3871321 ccgtggggag aagaagcatt tgcaaaagca aaacgcgaaa acaagccggt tctggtcagc 3871381 atcggttatt cgacgacttg tcattggtgg cctgggataa tcaaatcgtg tggaactcca 3871441 ttaaaagata acagaagcca ttttaaacga taatactatt tgttcaaaca atacagtcta 3871501 ccttttattt cattcatttt ctaaaacctg taatccgtaa ccacgcggta gcaggttttt 3871561 ttatttgctt gacttagagt taactctaaa ttgtaaacta actttaatta aatgagaggg 3871621 atgatgttgt tgtattccat tagtaaagct gctgagaaga ctagtattag ttcgtataca 3871681 ttaagatatt acgaaaagat tgggttactt ccaccaccaa aacgaaaaaa cagtggaagg 3871741 cgtttttata cggagactga tattcagttc atgttattcc tgaaaagttt aaaggaaaca 3871801 ggtatgtctt tggaggatat taatgagttt gtcaaagacg gatgcatttt ggaaaaaatc 3871861 aattcggatg ttaaatcggc acaactctcc ccatctataa ataaacgtat tgagatttta 3871921 accaagcact tagagaaaat ggaaattaaa aaaagggagc tggaagaagt gatttctact 3871981 acaaaaggaa aactggatac atattattca attttgaaag aggaagtgga aaacaaatga 3872041 aacatttaaa tatatacata atgttacttg gcttctctat tttcacggga gctactttta 3872101 atcttgcaaa atatacagtt ggatattttt ctccatcgtc ttctgcggca tggcgtttcg 3872161 gtttagcggc tgcagtgatg ctcatcattt tgatttttac tgaaggtata aagaagagtc 3872221 aattacggaa aaacgccgtt tcatacattg ttcttggaat tataggaatc tttggattta 3872281 atgccttgtt ttttgttggt ttaaaatata catctcccgt taacggagca ttaataatgg 3872341 ggctgaatcc tttattaaca gcaattctcg ctcgaattat cttaaaggac aacatgacaa 3872401 aaaaacaagt actcggcata ttctttgcat tcatcggtgt attgttagtc attacacaag 3872461 gttctatcga aaccattaaa accttatcaa tttcaggagg agacttaata atctttacag 3872521 gtaacgtttg ttgggcactt tatggcgtac ttggacgtcg gtttgtaaag gatggtacac 3872581 cgctatctac aaccacttat acgatggtta ttggtgctgt tagtttaata gtagtttcct 3872641 tatttacatc caaacctgtt tctttatcga acatcccgat tggagtttgg ggggcaattg 3872701 cttttatggc tttttttaca agtgttttgg gttacctatg gtggaatcag gggattaaag 3872761 agattggagc tagtaaaaca tctttatttt tcaaccttgt tcccgttgta acgatgatta 3872821 tttcatttgc cgttggaaca ccaataaagg tatttcaagt tattggggct gtgctagtta 3872881 tattaggcgt tttaaccgct tcgggggtaa tacgtattcc taagtacaat actaaagaac 3872941 agtcagctat ataaagaaat agggagtatt tttgagaaaa tgtgttaagt taaatataca 3873001 ctaattatag gaagaaggtg atcccatgcc aaacaaaagt aaacccaata gattaatcaa 3873061 tgagaaatca ccatatttac tccaacacgc ccacaaccct gtggactggt tcccgtgggg 3873121 agaagaagct tttgaaaaag caaaacgcga aaacaagccg gttctggtca gcatcggtta 3873181 ttcgacttgt cattggtgcc acgtgatggc ccacgaaagc tttgaagacg aagaaatcgc 3873241 gcgtcttctc aatgaacggt ttgtggcgat taaagtcgac cgggaagagc ggcctgatgt 3873301 ggattctgtt tatatgagaa tctgccagct gatgaccggg cagggcggct ggccgctgaa 3873361 tgtgtttatc acgcctgatc aaaagccgtt ttacgcgggt acatattttc caaagacgag 3873421 caaattcaat cgtcccggtt ttgttgatgt gcttgagcat ctgtctgaga cgtttgcgaa 3873481 cgaccgcgag catgtcgagg atattgcgga gaacgccgct aaacatttgc agaccaaaac 3873541 agctgcaaaa actggtgagg gccttagcga atcagcgatt caccggacat tccagcagct 3873601 tgccagcggg tttgacacga tctacggcgg tttcgggcag gcaccgaaat ttccaatgcc 3873661 tcatatgctg atgtatttgc tacgttatga tcacaataca gggcaggaga acgctctata 3873721 caacgtgacg aaaacattgg acagcatggc gaatggcggc atttacgatc atatcggcta 3873781 tgggttcgcc cgctattcga ccgatgacga gtggctcgtt ccccactttg aaaaaatgct 3873841 gtacgacaat gcgctgctgc tgaccgctta tacagaagcc tatcaggtca cgcaaaacag 3873901 ccgctataaa gagatttgtg agcagatcat tacgttcatt cagagggaaa tgactcatga 3873961 agacggaagc tttttctcgg ctttggacgc ggacacagaa ggagaagaag gaaagtacta 3874021 cgtgtggtca aaggaagaga ttctaaaaac gctcggggac gatctcggaa cgctgtattg 3874081 ccaagtgtat gacatcactg aagaaggaaa ctttgaaggc aaaaatattc ctaacctcat 3874141 tcacacaaag cgagaacaaa tcaaagagga tgccgggtta accgaaaaag agctcagtct 3874201 caaactcgaa gacgcaagac agcagctctt gaagacacgc gaggaaagaa cctatccgca 3874261 tgtcgatgat aaagtgctta cctcatggaa cgcgctgatg atcgcgggtc ttgcgaaagc 3874321 ggcaaaggta taccaggagc cgaaatatct cagcctagcg aaagacgcca tcacatttat 3874381 tgaaaacaaa ttaatcatcg acggccgtgt gatggtccga tatcgtgatg gcgaagtgaa 3874441 aaacaaaggc tttatcgacg attacgcttt tctcctatgg gcttatctgg atctctatga 3874501 agcttcgttt gatctttctt atttacaaaa agcgaagaaa ctgacagacg atatgatcag 3874561 cttattttgg gatgaggagc atggcggatt ctacttcacc ggacacgatg cagaagcctt 3874621 aatcgtacgg gaaaaagaag tgtacgacgg cgccgtgcct tcaggaaaca gtgtggcagc 3874681 tgttcagctg ctgcgtctcg ggcaagtcac aggcgactta tcactgatcg aaaaagcgga 3874741 aacaatgttt tccgtgttca agccagacat agaagcgtat ccgagcggcc atgctttctt 3874801 tatgcaaagt gtgttaaggc atctgatgcc taaaaaagaa atcgtgattt ttggcagcgc 3874861 agacgatcca gccagaaaac aaattatagc ggagcttcaa aaagccttta agcccaacga 3874921 ctccattctg gtggcagagc agcccgagca atgcaaagac attgcgccat ttgcagcaga 3874981 ctaccgcatc atagacggca aaacaaccgt ttatatttgt gaaaacttcg cctgccagca 3875041 accgacaaca aatattgaag aagcgatcca cacattaata agcagcaggg attaagaccc 3875101 ttgctgctta ctttttgatt tcttatggta ccataaagcg atccccgcaa acacaaggtt 3875161 gaccgctatc gtaaagaaag cctcccacat cgggttcccc cgcgtaacgg taaacagaga 3875221 aggaattcct ccatacacac tgtttttttc tgtaataaac atacacaaaa acatattatt 3875281 cgcggcatgg gcgccaagtg atatttcgat gctcccagtt ttaatcgtgt aatacgtcca 3875341 cacaaaccca aatgttaagt actcaattcc tgcccagaca gcgccattgt tcatttctgg 3875401 attcgcaaaa tgcaatacgc caaacaatcc tccgacaatc agtgtcaaaa atagaggatt 3875461 tttcgtcaat ctcccgaaag cttgaagcaa aaatcccctg aaaaatagtt cctcagctga 3875521 tgtctgaatc ggaaccaaaa tgagggcagc cgctagcagc cagataaatc gtgatgcatt 3875581 aaactcttgc attgaatagc tatcaggatg aatcacaaaa tcaatcaatt gtacggcgat 3875641 cattagcaag aaataagcaa taaaaccaaa ggaaattctc cgccaattca tctttgaatt 3875701 tggtgttatc accgttcgga aaggccgctt caaaataaag cgcacagcca gccaaactcc 3875761 cggaatggcg aataaataaa tcacatggga caaataaaga tctacgaggg gatcactcag 3875821 cacagcttca tccaaatcaa acgtgatatt gggattcaca ataaccgtga acaatatagc 3875881 gaaaaggtaa gctatattcc ctaatacata taaccctacc atcaccaaaa aagcgaaaaa 3875941 atatctccac aacgtattgt ttccttctat aggacggata aatgaattca ttccttctat 3876001 gtctcttcct ttcaatgaga atattactat atatttgcat aaattggtct atgaatctac 3876061 tgttttggaa atcttttaag caaaattaaa atataaagtg tgaatttagt tcttccatct 3876121 agtgatttga actctgttgc caatgaacca agatacttat aatagtccca agaggggaat 3876181 tttcagtctt ttctactact caaaaggggg ttttttatga atacgatctt caaacaaaag 3876241 aatacacatc ctttctcaaa cgcagcgaat cgtttagacc gccttccgat ttcacgcgtt 3876301 catttccaag tgttaaccgc tctcggcatt gtttatttct ttgatctcgc agatttattt 3876361 accctcagca acgtagcgcc ggcactgatc gagcattggg gcatcccgct ttcaactatt 3876421 gctaacgtaa cggccgcttc gtttttaggc atgtttttag gcgcttcact gggcggacgg 3876481 ctgtccgatc gaatcggccg caaaaaagcc ttaaatctat ttgtctttgt tttctcaatc 3876541 gcatcgctat gcaatgctgc ggcatgggac attccatctt taatgacatt ccgtttcctc 3876601 accggatttg gcgttgcagc cgccatggtc attacgaata gctatttggc ggaatttttc 3876661 ccttcaagtg tacgtggaaa atatatttct ttttgtgcca tgattggatt gattggggtt 3876721 ccgatcacca acattgtgtc tgcctttgtc attcctcttg gttcatgggg atggaggcta 3876781 gtatttgtat ggggtgccgt cggccttatt tattttttct tcatccaccg tctggaagag 3876841 tcacctcgct ggcacgaaaa tcgcggggaa tatgcgaaag ccgatgcgat cctcacccga 3876901 attgaagaac aggttgaaaa ggagaaaggc ccgcttccgg cagcatccca gcctaaagta 3876961 agcgaaactg ttaagcagaa tgcaggttac gcaggcttat tgaaaggcag aaacctcaaa 3877021 attaccatcg tattatctgc tgtatggatt tttgaaacgt ttgggtttta cggatttgct 3877081 tcatgggttc caagcctgct aaaaagcaat ggcgtaacca tggaaaatac attatggtat 3877141 aacgtattgc attccgtcgg cgctccactt ggcgcactgc tcggctccat gatttccgaa 3877201 agatttcaaa gaaaatggat tttagctgcg agtgcgtttc tgacggccat cgccgggctc 3877261 ttatatggta tgacttttat tcccatcatg atcattgtat ttggttttat cgtgaatatc 3877321 acagaacggg tctttacctc gaacttatac gcctatacat ctgaacctta tccgactgaa 3877381 taccgctcgt ctggcagcgg tttagcctat ggtcttggcc gtttttcaaa catttttggc 3877441 tcattgcttg tcggatttat tgccgttcag ctcggctata tcagcgtctt cttatttatt 3877501 gggggctgtt ggctcgcatg ctccttgctg ttaatcttct tcggtcctaa tacgaatgca 3877561 aaacagattt aaaaaagtca gtgcggatct gccgcactga tctcattaca attgcttcaa 3877621 aatccttgcg gggtttccgc ctacaacagt attagcgggt acatccttag tgacaacaga 3877681 tccagaagca atcactgcgt tatcaccgat tgtcactccc gggttaatca ccgcccggcc 3877741 tccaatccaa acttgatctc caattgtcac aggcttaccg aactccttcc cggatttcct 3877801 ttcgatcgga tcaagaggat gaccggccgt gtagatatgt acacctggcg caatcaaaca 3877861 atgacagccg atacgcacct cacacacatc taaaatgaca cagtcaaaat taacaaatgt 3877921 atgatctccg atatgaatgt gatagccata atcacagcgg aatgtcggca aaatcgtgac 3877981 ttgatcccca accgaaccga gcagctcctt caaaagcttc gtccgcactg catcatcttc 3878041 cggtgtttcg ttgtattgtc taatcagctg tctcgcatgc ttgcgttcta gtaatagttg 3878101 ttgatcttcc gaattgtata attctccggc tgccattttt tctttttctg tcctcagcat 3878161 ttaagtcact ccagatgtca gattgtaatc tcgatcaaat ttccttcatc atcctcaatc 3878221 acgctttcat agtagccgtc tcctgttgtc ctcgggccgt ttactactgc gaaaccatcc 3878281 gccttcaatc gatcagtcag ttcgtcaact ttctcccggc tcccaacgga aaaggcaata 3878341 tgtgcccagc ctgtcattgt ttgtgagggc ggatcggtca cattcccttt tttcataatt 3878401 tccagccttg ctccggaatc aaacgtaata aaataagact taaaatcttt tttctcatta 3878461 tgatacaaat cattcgcttc gccattaaaa tacgattcat aaaaagactt cattcgctct 3878521 aaatcattga cccagaccgc tgtatgttca atctgcattt cttcctcctc cttcgccttc 3878581 aatgaagtta taaggtatga aatgcatttc agttcaagct tttttcttaa atttatgctg 3878641 aattttgata tcagcgggtt catcctgcaa aaatagagaa aatgctgcga tgccgagctg 3878701 ctcaagattc aaatcaagcg acggaaaacc aagaacacgg ctgatagaag tatttccctc 3878761 gcctatgatt tcaacatccc aattattctt tttggcaaat agatgaattc cagctgccac 3878821 ttcatcacta tttgcataaa tagcagtcgg aacccgcccg ctcatataaa aatgttcagc 3878881 tgccagctca ccatcattca tatcgttgca tccggacagc atatggcggt cttccaacct 3878941 tccgcagaca gctttatagg ccgcagcttt atcagccgtg ctcgggctcc tatcagcttc 3879001 tctgacacac gtaaaagcaa tattctcatg cccgcggctc tttaaatagc gaaagctctc 3879061 tgcataagca gtttttctgt cattaaaagc acaagggaca tcaatgtctc cggtatcctc 3879121 acaagcgatg accggcccat attcctgata agctaaaatg ctgtcccaat gattggcgcg 3879181 ggaagtaatg atgagaccgt ctattttctt cgttcttaac agctctaaat atttgatttc 3879241 aatatcgggg ttataattgg tggggagaag ggtcgttgca tactcatgct gaaaagccgc 3879301 cttggtgatt ccgttaacga ttttatcaaa gcagggatga tcgctataag gcagaatcac 3879361 accgaccgta tgggttttcc cgcgaatgag atcgattgcg gttcgatttg gtgtataatc 3879421 caattccttc atgacttgat gaacaagctt tctcttttct tcagatacat acggatgatg 3879481 attcaataca cgcgagacag tcgaaacaga tacatttgcc agtcttgcga tctcttttat 3879541 atttgccatc tctttctcct tttcatataa aaaaagcagt aagtgtaaaa tccttactgc 3879601 tatctcatca tatattgatg ataagttcaa caggacaatg gtcggaaccc atgacgtccg 3879661 ctgatatgct ggcatcttca atctgttcct taaggctttc agaaacaaca aaataatcaa 3879721 tccgccatcc aatatttctg tcccgggcgc cggcacgata cgaccaccag gaataagcgc 3879781 cttcaagatc aggataaaca tgacgaaaag aatcaacaaa gccagcttct aagaaacgag 3879841 tgaatgcctc tctttcttga tctgaaaatc cagcgttatt ccggttcgcc tttggatttt 3879901 tcaagtcaat ctcctgatgg gctacattca aatcaccgca taaaatcact ggttttttct 3879961 gatccaattc aagaatataa gacagtaaag cctcttccca ttgcatgcgg taatcaatcc 3880021 gctctaatcc ccttctggaa ttgggcgtgt aaacagtcat cacaaacacg ttttcaaatt 3880081 ccagcgtaat cactctgcct tcttggtcat gctcttctac tccgataccg tagatgacct 3880141 gcagcggttc ttgcttagaa aaaacagctg tgccggaata tccttttttc actgcataat 3880201 tccagtacac atgatagtct tcaggctgga gatcaacctg gccgtcctgt atcttcgttt 3880261 cctgaagaca tataatatct gcatcctctt ctttcaaata agagaggaaa tccatttttc 3880321 tcatcacagc ccgcaggccg tttacattcc atgaaatcaa cttcatgttt catcctcccc 3880381 cctataaaaa agagcaagaa cccgaaggtc cttgctcttt acatatcagc ttactcaccg 3880441 cttacgtatg gaagtaaagc catttgacgt gcgcgtttga tcgctgcagt caatttacgt 3880501 tggtatttag cgtttgttcc agttacacga cgtggtaaaa ttttaccgcg ctcagaaaca 3880561 aactttttaa gaagatctac atctttgtag tcgatgtgcg tgataccgtt agaagtgaaa 3880621 taacacactt tacggcgttt cgcacgaccg cctctgcgtc ctcctgccat tgtcatttcc 3880681 ctcctttctt tttcatttta ggcgataatc acattagaat ggaagatcat catccgagat 3880741 gtcaatcggt ttgccgtcgt tggcaaatgg gtcatcatta aagctgttcc cctgattgcg 3880801 tctctggttg ttttgatttc ccccaaatgg attatcattt tggcctccgc caaagtactg 3880861 gcctccgccg ctgtttcctt cgttgtatcc acctgaacca gaaccgccgc cgtttttcgg 3880921 ctcaagaaat tgaacacttt cagcttggac ctctgtcacg aagacacgct gtccttgctg 3880981 gttttcatag tttcttgttt gtaaacggcc atctacgcct gcaaggcttc cttttttcaa 3881041 gaagtttgca acgttttcgg cttgtcttct ccaagtgaca caattaatga aatcggcctc 3881101 acgttctccg gactggttcg taaatgtacg attcacagca agagtaaacg tagcaacagc 3881161 cgcaccgttt ggcgtataac gaagctctgg gtcttttgtc agtcttccga ctaatacaac 3881221 tcggttaagc ataagaaaga ccacctttta ccattatata tttcaaaatt gcttattctt 3881281 cttctttaac aacaatgtgg cgaatgatat cgtcactgat cttagctaga cggtcaaatt 3881341 cttgaactgc cgcagcgtca gattgaacgt ttacgatttg gtagaaaccg tcgcggaaat 3881401 cgttgatttc gtaagcaaga cgacgtttac cccaatcctt tgttccagtg atctccgcac 3881461 cgttagaagt cagaacgttg ttgaaacgct cgataactgc ttttttagac tcttcgtcaa 3881521 tgtttgggcg gataatgtac ataacttcgt actttctcat ctgtttgcac ctccttttgg 3881581 actaagcggc ccataatggg caaggagcaa taattctatt actcacaatt ttatattata 3881641 ccaaagctct tgtcccttta caactgcatc ctatacatta aatcggaaat gaataacatc 3881701 tccgtcttgg accacatatt ctttcccttc aaggcggact tttcctgcct ctttagctcc 3881761 tgccataccg ccgcccgcaa gaagatcctc ataagcaact gtctcagcac gaatgaagcc 3881821 ccgctcaaag tcactatgaa taattcctgc acactcaggg gctttcatgc cttttttgaa 3881881 tgtccaagct ctgacttcct gttctccggc tgtgaaatat gttgcgaggc cgagaagaga 3881941 gtaagacgct ttgatcagct gatcaagacc tgattcttga atgcccagct cttccaagaa 3882001 catttgcttt tcttcgcctt caagctcagc gatttcagat tcgatttttg cacacacaac 3882061 gataacttct gcgttttcgc cggcagcgta ctcgcgaatc ttcgctacat tttcattgcc 3882121 agatggatca gcaacttcat cttcacttac gttggccacg tacaaaatag gcttcgaagt 3882181 cagtaaatgg agctgcttca caagcttttg ctgctcttca gtgaattcta cagatcgagc 3882241 aggcttttca ctctcaaacg cttctttcag tttagataaa atctcaaact caaatacagc 3882301 gtctttatct ttttgcttcg caagcttgct gacgcgtgta atccgctttt caactgtttc 3882361 catatcagcg aggatcagct caaggttgat cgtttcaatg tcatcaatcg gatcaacctt 3882421 tccggaaacg tgtgtaatgt tgtcatcgga aaaagcacgg acaacgtggc aaatcgcgtc 3882481 aacttggcga atatgagata ggaacttgtt gccgagtcct tctcctttag atgcgccctt 3882541 tacaatccct gcaatatcag tgaattcaaa agcagtcggc acagtcttct tcgggttgac 3882601 cagctcagtc agcttttgca gacgatcatc cggcacctct acaattccca cgttcggatc 3882661 aattgtacag aacgggtagt tggctgattc ggcaccggcc tgtgtaattg cgttaaatag 3882721 tgttgatttt ccgacgttcg gcaaaccaac aattccagct gttaaagcca ttctttcatc 3882781 tcctctatat aaaaccgtca ttgtatgaac gtattttgaa cctagagcaa ttataaggag 3882841 gttcactgga aaagacaagc tgacaaaaaa gcattttcag cttgccaatc cctttgatta 3882901 tgcttttttc aagcctacta aacagtcaaa aagcgtactt cccattccat tatcagaatt 3882961 tgtatcattt gtcagtgcat tgactgaccc tccaaaagcc gcccacatgc cttcatctat 3883021 attaatcgtc ttcgcatgag cctgcttcat cactttcacc ttgcccttca tgcttccgcg 3883081 gtcattaaag atgacaactt cgtctccatc ctgaagatcc tgcccagccg ctatatctgg 3883141 agaaatatcg acctgaacgt gctgaagctt ttcaataaac ggcacatgct gtgaatgatt 3883201 ggaacgctgc ggatgaatgg ataagagcgt ataagggtac tttccagcta actcctcatt 3883261 atggaaaaca gattcttcgg gcacatttaa ttgaagcgag ccgctaaatc ctttttgctc 3883321 agctagcgac gaagtaaatt caaattttcc actcggcgtc aaaaactgat aatcatccca 3883381 cggcacctgt tttactggaa gagggaggtg gcctttttct tttaaacgct caagtgtcac 3883441 atcctctgct tccaatgaag aaagccccat ctctaaaaat tcttgagtgc tgtattcaaa 3883501 cagctcgcca aacccaagac gttttgcaag ctctgaccag atccagctgt ccgatttcgc 3883561 ttcaccctgc ggctccacaa gcttcttccc gtactgaaca taatgatgat acatactgga 3883621 atagtagata tcttcttctt caaaaacagt ggcagtcggc aaaacataat cacacagctc 3883681 tgcggtatcc gtcataatgg aatcaatcgc gaccgtcatt ggaacctttt caaatgcttg 3883741 tctcacctta tttgtattcg gcacctgagt cagcggattt ccgcacgtca caataatcat 3883801 ctcaatcgca ggatcagcag cggtcaacac ttcttcagcc tgtgtcatca ttgaaaaaga 3883861 acgggatgtt gtttttaatt ccggcagcgt cagctttgtt tttgcaaagc tctcaccaat 3883921 ctggacattt ccgaaattcg cgccgccgcc cttaattccg acatttccgc ttgccgccac 3883981 aagtgcatca atccaacgaa tcgttccccc gccgttttta tatcgctgca tgccaagccc 3884041 cataaaagta gacaccggac catcagcata caaacctgcc aaatactcca gctcctccat 3884101 agaagtttct gttttcacaa taaactcttc cagagaaacg gtcttcaaaa gctctttcac 3884161 atcatcaaaa ccgacagaat gctcagaaat aaacgtttca tccgttcttc ccatctcaat 3884221 cagaaccttc aaaacggctg ccgcaagcca gccgtccatt ccaggcttta cagagatata 3884281 gcggtcggca agcttagcag tcgggttgaa gatcggatca atcaccgtaa tcgtggcgcc 3884341 cttctttttc acctgctgca agtgatggta taagtgcata tttgttcttg atacatttct 3884401 tccccacaca acaacatgct tgctgttgta aatatcaagc ggtccgtgac cgtacgaacg 3884461 gccaaaatcc cagctttgcg cctcgatacc ggagccccag catatgcttc cgacgatttc 3884521 ggtcacgccg ccatatccat taaaaaaacg ctgatcaagc gcttttaaca gaccgttatt 3884581 cgcataatca tggctgtgca aaacagcagt cgtctccgac gtttccttga tttcccgaag 3884641 tttatcggca atttcatcaa gtgcctgctc ccaagaaatc cgcacaaact cgccattttg 3884701 ttttttcatt ggatagcgaa gccgatcagg cgaatttgtt tttgtctcaa gcattctgcc 3884761 gcggccgcag attttacctt ccgtaatcgg atggtttgga tctccgtcca cttttgttac 3884821 ctttccatca tcaacagtca ccaaaaagcc gcagctgtcc caacaattca gcggacatgc 3884881 cgactgatgc actttgctca tcgccgtctt ctccttacct tctatatgaa aaagcatgag 3884941 tgtcggccta tttatgaagt aggctcctca tgcttgacta gtactttttt tagttttctt 3885001 tcaaattctc ttctcggaat cataacactg tgagagcatc cctcacactt aattcgaata 3885061 tccattccca tgcgtataat tttccagctg ttcgctccgc atggatgcgg ttttttcatt 3885121 tctacgatat cattcaggcc aaagtcttta tccgccaaga cccttcacct cttttcctaa 3885181 actgctgtat ctattgtaca aaaaaactga tcataagagc aatcaagata cccgaaaaga 3885241 aatacatcct cttatttcca tttactcaaa ataggatata agagcagaca aactaacaaa 3885301 tacaaattga gcatcccata tatcggatac aagaacgcga tcaaatcaga aaatccgaaa 3885361 gaagtaaaag gtaccattaa cactaacaaa atcaacacaa tcatccatct cggcatatga 3885421 ataaacgcca tcagccggct ggacaaaccc agcaaaccag ctaccgtcgt cgtgtaaatc 3885481 gccaggcaca gcaccgccgt catacataaa aaaaggaaat aaggcgcacc ctccagaacg 3885541 gcaaacagcg gtatttcaaa ctgagaaagg gagcccgcca gctccaccaa cgtttcatta 3885601 taaacaaatg agatcacgcc aaaaataaga ccgcttgcca cacttgcgat ttttgcttct 3885661 ccgagccctt tcatctcttt cccaacagag gataaaatcg caacaactga aaggatgttt 3885721 aaagaggtaa acgtaatgct cgcaggccag ttatactgct gggacaaatc aatcgtccac 3885781 gtatggtgat gtgtgctctg aaaggagatc agcgcatata aaagccccgc tactaacaca 3885841 ggaatcaaaa tactatttat agataatatt cctttcacat cccacaaaaa caagcacact 3885901 gtcacgatgc aaatcagcgt gattccccac cagaaaggaa gcttgtacat ttgcagggtc 3885961 acaccgcctc cggcaatcat caccatagtc gtcgaaaaca aataaaaaat gatgaggaca 3886021 tcataaattt tcgccagcca tggccccatt aaatgctcca gaaccggcag aaaatgagtg 3886081 gattgaacct taaaactgat tttcatcaca atataagacg agaaaatgaa cataattgta 3886141 aacagcacaa tagcaagtcc gctttccgcc ccaaaaaact gccatatctc ctgaccgctc 3886201 gcatatccgg ccccgatcag gctccctaat atgagcagca tccacttcat tccggctctc 3886261 cacaacacta tcacctcata gacaaagttc agcttgttcc cgttattgtt actatataaa 3886321 taaaggaaag caaacatgcc atattttcat agacatttga acacaagctg aaattatcat 3886381 acgaaataca cataaaaaag actgctaata cggcagtcta aaaagagata tttatttgtt 3886441 tgtccgcgga atgaagaagt gaacttcact cttcactttt ttctaaccat tcctacctat 3886501 tcaagtgttt cataagcaga ccattgcttg atcatgatcg aggcaatggg ggacaatact 3886561 tgtaatcgcc cactaaccat tcatatcatg ccctctactt ttttaaaatc tctggtgcca 3886621 tacacaaagc ataaaaaatc atactgctgg atatactgta aacaacctta cataactaca 3886681 cacaccatag caattctgtt acctactata acaaggaagt gaaacccatg aatcgaaaag 3886741 gcgggctttt ttcttctcag gaacgagtaa agcaatatgt ttcacataca gatgctgcag 3886801 cggcaaaaca aatccaaacc atcctttctt catccttacg taaagctgct ggcaaaccaa 3886861 ttgtcgtggt ttgtatcgga acagaccgtt caaccggtga ctcattaggc ccgctcgtag 3886921 gaatgaaact caaacagatg cagctcacca gattccatgt ctacggaacc ttatctgacc 3886981 ccgtccatgc tgtgaacatg aaggataaaa tcaatgacat tcataaatta cataaaaacc 3887041 catttgttat agcagtcgat gcatgcttag gccgcgttaa gagtgtgggt tcatttcaaa 3887101 tcggggacgg gccattaaag cccggagccg gtgtacaaaa agaccttcct gaagtgggag 3887161 atcttcatat taacggaatc gtgaatgtga gcggttttat ggaatatttt gtattgcaaa 3887221 atactagact caacttggtc atgaatatgg caaatgttct agcggaaggt ttgagtttaa 3887281 cagatcggac agagtggagg caagaacgcc ttaacccgtt gcaaaggctc actgggcgca 3887341 tataaaataa aaaccatctt cgtttgaaag atggtttttt catttatgat tctcgttcag 3887401 acaaaagctc taaaatccgg tcaaggtctt cattagagaa aaattcaatt tcgattttgc 3887461 cttttttctt ctgtctttta atattaactg ttgttccaaa ataattttgg agataggatt 3887521 cccgttcttt tagaaccgca tctttcacag gttctttttt ctttgtttca cgtggaacat 3887581 tctgattcaa ctgctgaatc agctgctcaa gttggcgaac attgagctgc tccgcaatca 3887641 ctttttgtac cagcggttca agcttatttt tgttttttaa gccaagaagc gtgcgtccat 3887701 gtcccataga aagcgtgcct tcggcaataa gctgttgaat attttctggc agtgtcagca 3887761 gtcttaaatg attcgcaata tgcggtctgc ttttcccaag acgtttggca agctgctctt 3887821 gtgtgagatc taagtgtttc aaaagggagt catatgcctg agcctcttca agcggagata 3887881 aatcttcacg ctgaaggttt tctaataaag caatttccct cattaacgcc tctgataatt 3887941 cacggacaat ggccggaact gtatctaaac ctgccagctt tgccgctcga aaacgccgtt 3888001 cacccgcaac aatatcatag ccttttaaag attttctgac gataagcggc tgaagaatgc 3888061 catgctgcag cacagattct tttagttcag ctaatgcctc gtcatcaaag tgttttcttg 3888121 gctgataagg attagggcgt aaatcggcaa ttttaatttc ttcaactgtc tcttcagaca 3888181 aatctacctg attaaataac gcattaatcc cttttccaag gcctttagcc attcgcagcc 3888241 acttcctttg ctaaatctaa atatacttcc gcacctcttg accgcggatc gtataaaatg 3888301 atgggttttc cgtgactcgg tgcctcactc agacggacat tacgcggaat aactgtctta 3888361 tatactttat ccctaaaata ctttttaacc tcttcaatca cttgaatgcc aaggtttgtc 3888421 cgggcatcaa gcattgtcag caatacacct tcaatcatta aatcagtatt caaatgcttt 3888481 tgcacaagac gtactgtatt taataactgg ctgagaccct ccaaggcata atattcgcac 3888541 tgtacaggaa tcacaacgga atccgaggca gtaagggcat taatcgtcag caagcccaat 3888601 gacggcggac aatcaatgat aatataatca taattttgct ttactgcttc aagcgctctc 3888661 ttcaatctca cttctcttga tattgtagga accagctcga tctcagcccc tgcaagctga 3888721 atcgtcgcag gaatcacatc caagttctct actgtcgttg ctttaataat atctattaca 3888781 tctgcatcat ctactaaaat atcgtacaca cactgctcta catcggcttt ttcaatccct 3888841 aatccgcttg tcgcatttcc ctgcggatca atatctacca gcagaaccct tttccctatg 3888901 taagccaaac atgccccaag gttgacagac gtcgttgttt tgccgacccc gcctttttgg 3888961 ttcgtaattg ctatgatttt tcccacgatg tcacctactt tcacatgaac atgtactatc 3889021 ttgcttctat tctatcaaaa aaagattaaa gcgtttcatt tttttcatca ttttgttccg 3889081 aatcagaagg gaaataattg aaaattcaag cacgctttat gctttctctt ataaattctg 3889141 caatttctat gtttttttga cttaaaaaag gaatttctta aagaaaaaaa gaagaagtca 3889201 cagtacagaa cgtggaaaca ggatggtgag aaaatggttt atcaaacgaa gagagatgta 3889261 cccgttacgc tgatgattgt gtttctcata ttactgatac aagcagatgc cattgttcct 3889321 tttgtgctgg gaaatatgag agtttccggc tggatcattt ttattctgct gactctttta 3889381 aatggactca tcatttggag ctttattgac ctaaaatatg tattgaagga acaccatctg 3889441 atcattaaag ccggattgat caaacatcaa attccttatg aaaacatcga taaagtcgtt 3889501 caaaaaaaga aactatggtc cggttttcgt ctgatcggct ctcgccatgc catcacaata 3889561 tattatcagg ggggatgggg acatgcagta atttcaccgc aaaaatctga agaatttatc 3889621 cacaagctca aagaaaagaa ttctaatata ataatattca ctaaaagtaa gtgattacct 3889681 tttgttaaaa atataaaaag ctctcctgct tttcaggaga gcttctattt tggtatgcga 3889741 atcgttaatt gaatatattc ttcaaattct tcttcttccg tattcaattt tacaccgctg 3889801 tcttccacca ttgatagtga ctggcgaatc gtgttcatcg caattcttgt atctctgctg 3889861 aatgctttgc gtctcggctt tggctttctc tggccttgct ccagcatttt caccacgcgg 3889921 tcttctgtct gctttacatt taaacttttc tcaataatct ctgtgagcag tgtgacttgg 3889981 agctcaggct gtttcagcgg aatcagtgct ctggcatggc gctcggtgat tttcttctcc 3890041 ataatcgcct cttggaccgg ctgaggcagc tttaataacc gaagcttatt cgcgattgta 3890101 gactgccctt ttcctaagcg ctgtgcgagt gcctcctgtg ttaaatcatg cagctcaagc 3890161 agcctagcat aagcatgcgc ttcctcaata gaagacagtt cttcccgctg caagttttcg 3890221 attaacgcca cagaagcggt ttccgtgtcg gaaaaatcct taataattgc cggaatcttt 3890281 tcccactcaa gcgattgcac cgctctccag cgtctttcac ctgcaatgag ttcgtattgg 3890341 ccttcttctt ctgtatgcct aacaacaatc ggctgaataa tgccgtgtgt atgaatggtc 3890401 attgctaact ctttgatttt ttcatctgag aaaatggtgc gtggctgaaa acggttggga 3890461 acgatagcat ttaccggtat ttccagaatc tcttctttgt ttgtatcatg ttcagcaatc 3890521 tccggctcct gttccttctc accaagcccg aagaaacgag agaatgaatg cttcatgtac 3890581 ctacaccacc tttaaaaact gccattttta taattctatt ttctcatggt ttttcctgct 3890641 gtacatccat caattttgat gaaaatatga tggtattgtc atatcaggct gtctaaatta 3890701 cccttcaatt ggcgatttat taggagttcc cggttttctt ggatacttct taggtgtatt 3890761 ttttattttg cgtatcacca taatattacg atcgctttct tcaataggca gcttaaaaga 3890821 atggatattc tcaagttctc ctccaagcgt cgtgattgct tttttgcctg cattcagttc 3890881 ttcttcagct gatgcggctt ttaaagcaac aaataaaccg tttttcttca ccagaggcaa 3890941 gcaaagctca ctcaaaacag ataatctcgc aactgcgcgc gccgtcacaa tatcatagct 3891001 ttcacgcacg tctttccgtt gcccgaacgt ttcagctctg tcatggcaga atgttgtatt 3891061 ctccaattgc aaagcttcag acaacttttc taaaaacgta atccgtttgt ttagtgaatc 3891121 cacgattgtg acatggaggt gcggaaagca tatttttatc ggcagacttg gaaaacccgc 3891181 tcccgctcca acatcacaaa tcgtgttcac ctgattgaag tcgacataaa aagcagctgt 3891241 aatggaatca taaaaatgct ttaaatacac ttcttttttc tctgttattg aagtcagatt 3891301 gattttttcg ttccattcaa ccagcatgtc gtaatacagc tcaaattgct ccagctgacg 3891361 gggagaaagg gagatccctt tttccgccaa accagaagtg aattcttcaa tattcatgcc 3891421 gtcatccttt ctactcggct atcttcgcaa tgcgtccctg ctctaaatac accaatagaa 3891481 ttgaaatgtc cgccgggttt acaccggaaa tgcgggaagc ctgggcaaca gacaaaggcc 3891541 gtacattttt cagtttttga cgcgcctcgg tcgcaatccc cttaattgcg tcataatcaa 3891601 ttcggtctgg aattttttta ttttccatct tcttcagttt ttccacttgc tgaagagatt 3891661 tttcaatata tccttcatat ttcacttgga tttctacttg ttctgccacg tcttgaggaa 3891721 ccggcacttc tggcggcgcc agttttgtga ctgtttcata gttcatttca ggacgtttca 3891781 tcaagtctgt gccgcgaact ccatctttca attcgcttcc gccaagagaa cggatatatt 3891841 cttgattttc cggagacggc ttgataatta cagaatgaag acgttttttc tccgcctcga 3891901 tcgccgcttt tttcttctca aaagccgcat agcgctcatc agaaatcaat ccaatgcgat 3891961 gtccgatttc tgtcagacgc aaatcagcat tgtcatggcg aagcagcaat ctgtattccg 3892021 cacgtgatgt caaaagacga tatggctcat tggtaccttt tgtcacaagg tcatcaatca 3892081 gaacaccaat ataggcgtca gaacggctta gaattacttc ttcttttcca agcgcttttc 3892141 gtcctgcatt gattcccgcc ataatccctt gtcccgcagc ttcttcataa ccggatgttc 3892201 cgttaatttg gcctgcagta taaaggtttg tgattttttt ggtttcaagt gtcggccata 3892261 gctgtgtcgg tacgattgca tcatactcga tcgcatagcc ggctctcatc atttgcacgt 3892321 tttcaagtcc aggaatcgtt gcaagcattc tttgctgtac gtcttctgga agacttgtag 3892381 ataaaccttg gacatagact tcctgtgtat ttctgccttc cggctcaagg aagatttggt 3892441 gacgcggttt atcattaaaa cggacaactt tgtcttcaat ggatgggcag tatcttgggc 3892501 ccgtaccttt gatcataccg gaatacatcg gtgaacggtg caggttgctg tcaataatct 3892561 catgtgtctc agggcttgta tatgtcagcc agcaagggag ctgatctgtg atatattcca 3892621 ctgtttcata tgagaaagcg cgaggcacat cgtcaccagg ctgaatttcc gttttgctgt 3892681 aatcaatcgt gtcgctttta acgcgaggcg gcgtacctgt tttaaaacga acaaggtcaa 3892741 aaccgagttc ctccaaatgc tcagaaagct taatagaagg ctgctggtta ttcgggccgc 3892801 ttgagtaaga cagatcgcca agaatgatac gtcctcttaa atatgtccct gtcgtcatga 3892861 caactgcttt cgcacgataa tgtgcgcctg tttgtgtaat aacgcctcgg cattcgccgt 3892921 cttcaacgat cagccgctcc acaattcctt gcagcaatgt taagtttggt tctttttcaa 3892981 gcgtattttt catttcgtgc tgatattgga atttgtctgc ttgcgcacgc aatgcacgaa 3893041 ccgcaggacc ttttcctgta ttcagcattc tcatttgaat atgtgtttta tcgatgtttc 3893101 ttcccatttc tccgccgagc gcgtcaattt cgcggacgac aatccctttt gcggggccgc 3893161 cgacagacgg attacatggc ataaatgcaa ccatatctag gttgatggtc aagacaagcg 3893221 ttttggcgcc ttggcgtgca gatgcgaggg cagcctcaac accggcatgc ccggcgccaa 3893281 tcacaatcac atcgtattgg cctgcttcat accccatgat tctagttcct cctttaatta 3893341 ttttcctaaa cagaattgag aaaagagctg atcaattaag ctttcgtgga cagaatctcc 3893401 aatgatttcc cctaaaagct cccagcatct tgtaaggtca atttgcacca tgtcgatcgg 3893461 gacatcctgt tcgatgccgc taagcgcatc ttcaatggcg cgttttgctt gctgtaaaat 3893521 agtgatgtga cgtgtgttgc tgacataagt cagatcaccg ctttcaatgg cacccgtgta 3893581 gaacagtgat tgaatcgctt cttccagatc attgatgcct tcctctttta aaagagatgt 3893641 cgtaacaact ggacgtccat tggcaagctc acggacacgt tcagtgtcaa tcttcggctc 3893701 aaggtcagtc ttattcaaaa tcacgataac atccatgccc tcaacggctt caaaaagctt 3893761 cacgtcttct tcagaaagct cttcactata attaagcaca agtaaaatca ggtccgcttc 3893821 ctttaggacc tggcgagaac gttcaacacc gattcgctca acaatatcct ctgtttcacg 3893881 aatacctgct gtatcaacca gacgaagcgg aacgcccctt acattcacgt attcctcaat 3893941 cacatcccgt gtcgttccgg gaatatcggt tacaatggct tttgcctcat gaacgaggct 3894001 gttcagaaga gatgattttc ctacgtttgg ccggccgata atgacggtag aaagaccttc 3894061 acgcaagatt tttccttgct cagaagtcct cagcagcgtc tcaatttcct ttttcacggc 3894121 ggttgccttt tcgactaaaa tctgatgcgt catttcctct acatcatcat actccggata 3894181 atcaatattc acctcaacat gggccagtgt ttctaaaatc tcactgcgca aacggcgcac 3894241 caaagcagaa agacgccctt ccatttgatt catagcaacg ttcattgccc ggtccgtttt 3894301 cgctctgatt aagtccataa ccgcttccgc ctgtgaaaga tcgattcggc cgtttaaaaa 3894361 cgcacgtttc gtaaattcac caggctctgc cagtctcgct ccctctctca atgcaagctg 3894421 aagcacttgg ttcacagtca caattccccc gtgacagtta atctcgatga catcttctcg 3894481 tgtaaaagtt ctcggcgctt ttaacactga taccattact tcctcaacga cacgatccga 3894541 aggtctgtct acgatatgac cataatgaat cgtatgtgat tcgaccgagc tgagtgtttt 3894601 ccccttcggt cccttataaa ttttatctgc gatttgaatg gcttctggtc cgctcaaccg 3894661 tacaatcgca atcgcgcctt ctcccatcgg tgtggaaatt gccgcaattg tatccatgtt 3894721 gttcacctct ctttacttat acttcatcta tataaaaaaa tttttattat gccaaaacta 3894781 aaagataaca tagtttggtt cgaagtggaa gatttgttat ccacagaaat agaaattcgt 3894841 cccttattac tttaacttat ccacatgtga ataacaatta attttatttc ctgaacttcc 3894901 tttttatcaa caggatacac ctaaaaagaa aaaacttaaa cggcaaaacc ttgatattac 3894961 taggaaaagt agatttttcg gatacaaaaa aaccgaaatc caatttttat cggacttcgg 3895021 ttttatgcta tcttttatgg gaaataacga gatgacgatt ttcgccttca cccattgaat 3895081 atgttttgat ctggtggttt gcatatccag aaagagtatc gtgaataatt tttctttcgc 3895141 tggacggcat gggctcaagc tggatggatt ttttcgtttt caaaacctgg tcagcaagct 3895201 tgatggccag ctggctcagt gtttcttttc ttttcaaacg atagttttct gcatccaccg 3895261 tcacattttt atattggcct ggataacggt taagggcaag ctgtgtcaaa gtttcaaggg 3895321 cgtttaaagt ttgtcctctt ttcccaatca acaatgctgc cttttcacct gttatatgat 3895381 atctcactgt ctttttgctt tcttgaacag tcacatcaga cttcccggca atggcttcgg 3895441 caatcgtttg aagatataac ttcgcttgct gaatcggatc aatcttttca accagcttta 3895501 cgatcgcagg ctttttaccg aaaataccga gaaacccttt gtttccctct tcaataacag 3895561 taatttctac cttatccttc gttaatccca actcttgcaa tccggactgt actgcttcat 3895621 cgacatttcg ccctgcagca gtcacattcc tcactttttc tttcctccgg ctttttgcgg 3895681 ctcaggattt tttttaatat caggtccttt aatgaggaaa gtttgcgcaa tcataaacaa 3895741 gttaccaact acccaataaa gagaaagagc cgccgggaag ttgatcgcaa atacgataat 3895801 cataattggc ataatccaaa gcatcatcgc catttgcgga ttttgctgcg cattgccagc 3895861 catcatcagt ttttgctgaa caaatgtagc gacaccggca acgataggaa gaatatagta 3895921 aggatctttt tctcctaagt caaaccataa gaagctatgc tctgaaatcg cctgggttct 3895981 catgatcgca tgatagaatc caattaaaat cggcatctgg atcaaaatcg ggaaacatcc 3896041 cgccaatgga ttgacaccat gcttttggaa taaagccatt gtttcctgtt gaagcttttg 3896101 ctgcgttttt tgatcctttg agctgtattt ttctttaagc ttttgcattt ccggctgtaa 3896161 agcctgcatc gctttcgaac ttctcagctg cttaatcatc agcggtaaaa ttaataaacg 3896221 aattaaaatg gtaactagaa taattgaaag cccgtagtta tctcccgtca atttcgctac 3896281 atacgtaatg agctcagaca atggatatac tacgtacttg tcccagaaat gcggactatc 3896341 tgcagtgatc ggctctttca cactcgagca tccagccaaa agcatgaata cgccaaccat 3896401 acttaatagc aaccctattc tccttttcaa caacatttcc tcctataatt aatctttaca 3896461 ctcttttatt gcaaagcata cttgtatgta ttttagcatc tttcagtttt aaatggtgtc 3896521 tttttctgat caaccagaaa ggaagcgctt ttaaaagttg taagaaagca gtggtgatgc 3896581 ctactttgac gaagatttct tatataatga agactttctg aatagatgct gcagactttt 3896641 tttcgtttcc tcatatgtca gctggctcgc cggttttctg gcaataatga tgtaatcctt 3896701 ttccttcagt ctctctttct cttcaagaaa ggcctgccga atcaaacgtt tgatccgatt 3896761 tcgcatcaca gcattgccaa tttttttgct gacggaaagc ccgacacgca gttcatcatt 3896821 ttcaggctga tcaagcgtat ataagacaaa ctggcggttt gcaactgatg tcccatgttt 3896881 aaacactttt tgaaaatctt catttttctt taaacgattt cgcttcttca aatgactcac 3896941 tccgatactg gctggcagaa acttttaaaa tttattatga acatgagatg catctgaacc 3897001 aggaagcatg ccccggttca ttacgcatca catctatctt ttcccataac gtgaaaaaag 3897061 accactgaca ttattcagtg gcctaagctg ataatacttt tctgcctttg cggcgacggc 3897121 gtgctaaaac tagacgaccg ttttttgaac tcatacggct tctgaagcca tgaactttgc 3897181 tgcgtttacg gttattcggt tggaatgttc ttttcattta tgacacctcc ctcgaggaat 3897241 agctgttaaa gacagtctta cttattatat ttgcgttacc tattcattgt caacttcact 3897301 agtgctttta tttcttgcaa ccataatagg ataccatacc ttttcaactt tcgaaacctt 3897361 attttttaga ttccttaatt ttacggaaaa aagacaaatt caaacaattt gcccctaaaa 3897421 tcacgcatgt ggat //